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<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1F0</accession>
    <name>K1V1F0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07943</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="12">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="12"/>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1F0"/>
    <dbReference type="FunCoup" id="K1V1F0">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V1F0"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1F0"/>
    <dbReference type="OMA" id="PPYDFND"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="169"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC97744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="263" mass="28337" checksum="8A8274F69194A272" modified="2012-11-28" version="1">MSLTRINIAPTCRTFASGVPAARVAFNLPPKADHHAGPRADMPAKFSGTFMKRVNAPPSGAFVAQRSMHTSTRALAGRSQATGVPDFTPYKTSNADSNRTLSYFMVGTLGALAASGAKSTVTDILSNMAASADVLALAKIEVEMGSIPLGKNLIVKWRGKPVFIRHRTPDEIAEANDVDVKTLRDPETDEQRTQRPEWLVMLGVCTHLGCVPIGEAGDYGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYSFNDDEEKIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1H5</accession>
    <name>K1V1H5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1H5"/>
    <dbReference type="STRING" id="1220162.K1V1H5"/>
    <dbReference type="eggNOG" id="KOG2163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537689_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1H5"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="507" mass="55940" checksum="0C5139C1C4CFC23D" modified="2012-11-28" version="1">MTAPISSNGELAKAIAFQPGPVTADVRRAAQGLEAAILQTQALVLPHAADIERQVGQSGNLLERATVTQRDLDEVENEFDANQPKTSQEGSYLAEITLKSLRSLKVSYDRLKAVEDAVWSGQSVDTTIRQDLKGISEIDSQRDRGQLLDSLVKEQLSTAWSAAFEIEQPTRVTMTLGNHSALTQSSTIAELCEALQGLDILGQCLAQLQTRILRELVTPLVSSRSLVSEGYGSELRELRFKQKGDASLIEVVSSIRDLVRFVTHALPSPLEAVSSFLSTFSEALYHRVLQEVVIPSIPRELNKLPPWLSDVRQCASWERGESEDSHKQVLQRFLDDQAGTRWLESHRAEGLLETRSLVFDGWKDWDFRLEETKRPTSSRPEENAIERDDGWGFDDEPSILPANEDGWDFDDLAPIPTDSIPAPSVKPAREAKRLGKKLSSKHASASQEALLNARELQRAPTPSAPPLHPEEAVAAPKSSVRVSVATSAALSLLGARLRELQDIESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3B5</accession>
    <name>K1V3B5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3B5"/>
    <dbReference type="STRING" id="1220162.K1V3B5"/>
    <dbReference type="eggNOG" id="ENOG502RBFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275473_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3B5"/>
    <dbReference type="OMA" id="MWREMEG"/>
    <dbReference type="OrthoDB" id="2564920at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1159" mass="124074" checksum="F64B3F7C8A1E0615" modified="2012-11-28" version="1">MYEATAADHKMNAPKHTMIPRGRSLTDPDLLLHIQSPSCSTPSTVRSAAPLRPRIETSDFALPLIPTIRADSPMSTHSRDPRMTEDLEPPRLWKTTSRGSQPNSPSVTSACPSPTPSATLSAYSVRLKTSSGGGEASGSRLQRKKSNASLLVKRGLTRMGSVMSRKGASAGGREGSRHGQHGSTSTPPRRRLPRNNSLTLDDLVEESNPSPSPGLMRVQSPNQPLLPSQICQSQVETGGVSRPFNVQLHVSENLEGLPMEWLDQLKAQGMSESELLLIVAAHKKQRSVPLHPINPTGRRKPVPNFTVGDVSAPTLSCSQRNPSGALEDAQGDVNVILRTPPKKHGRPGHDKSEPSETRKVPKEKPSLTIQVPPRERPKVQLEQGHMSPPSQRAHGATLAPAASSLTVAGSTLTWPRAASSAAPALRSVPTVTTAPTPVSPPKSGPDPSPQPLEASARSPTSASLPPTPTSTSASSKAGRRSRALSTQLRRSSSIITKLLTEFDTASSRPSRSSGQHLQPHSRGDHGSGSDTEEKRKGEHERGPSNVSANSFLTVGSVSSAGRRMSDEIRGFQNLNIDLTDGDEWAASILAAWDEEGGTEEPPEGTETAEVAPAPLQDEGTDAPEVDYVPEEAEIRVVRPPITKQASMISLRAVMEEAEERKERPRPKSVSLDRVYSPPPPPRPLRVASPVNNPAPPSEPRLVVPTTSSSRLRCVSVDSFGVQRRHSQTPTTSPSSSEIDLSTPPLDETATAVIALPKPMTQPLRLTSPRASPTPPLRILRSPKSASMNRSSSGQSLNVGAYRSRPSSQASKRDVHLSPSALSLNHARLSLQAKSSADSPSLYSPRSSRHYSPIRSSYSSHRASLPRPPPSRPPPDVPRSNTETTEGTSSTTPGAQAFPSTGSFLPFSEEEVHSPAEVSANDHRPETFSLPTSADSLTLEYTQHQRGQEHVRGQESIQSIESLFASSGALGLVLNLDGVNNRLSEGAALSRVSSCSSANYSYQLHEATVQRAYTRVLRRARESVHELGGDVDEVSSESAYGDDVYIPQDTLITPGHRSTPSGPTGVTPVDVAFVNARLIRVNELDDPEEGYHTAYASPRFDTNRMSTISGYSGSVYHSVSSATDADFQSAGQSTLPPLPISSHVNHPSPLGQLPPQPQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V739</accession>
    <name>K1V739_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V739"/>
    <dbReference type="HOGENOM" id="CLU_991077_0_0_1"/>
    <dbReference type="InParanoid" id="K1V739"/>
    <dbReference type="OrthoDB" id="2595693at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851658" evidence="3">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="283" mass="28447" checksum="3776AF356F70A386" modified="2012-11-28" version="1">MRLSLTTLLLLLATSILAQDTADVAGENDVMGGTDPTPTDGGEGDAAPTPAADSGDATDTGEGGGGGTGSTGADDNSLENTKDLTQPWNITYFTYPTRNNYWVNDNENKATWAPVNVATNLMLSHSNTSMLPQRIMLQQNIPGGVGTFATKITGYTPGNNYLLVLSIAGNPDQKLAQSQGFYIKANGTAAPQQVTAQGNQATASAVSNGGSTQPGSGDPAKMQQENAAPVDGGTGNGNGASASPNANAPAGHSAAERVGVWTGVGVAMGAMAAAVVAPLILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9A2</accession>
    <name>K1V9A2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000339">
        <property type="protein sequence ID" value="EKD00580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9A2"/>
    <dbReference type="FunCoup" id="K1V9A2">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_0_1"/>
    <dbReference type="InParanoid" id="K1V9A2"/>
    <dbReference type="OMA" id="FCYWLMG"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="526" mass="56657" checksum="A289363896F5AB8D" modified="2012-11-28" version="1">MSLSKHSLQEDEVRSVAPSAPSVRAPSSSAGVPYRNRAWTQLWLVSFCCFCLPGMYNAIQGLGGSGQLDPTVGANSSVALLSVGAATGLLVGQPMYDLLGNRCMALGAWTYPLYTASLLAYSHGCAKDGAFVIVSGAVLGLGATLLWVTQGAVMLSYPLAGQKGRSIAGFWVVFNLGGAIGSFISLGLNYNRRHAGTVSDGTYIAFMVIMVFGWCLSAFLLPPHLVIRTDGSRAAPLPASHVSHPSSLSSLSPPTVTSRLRHCYAVFASTARRELAQIAKLRHEPRLLFLLPLCFGANFFYSYQQNIVNGGSFTLRSRSLNSALYWGAQMLGGVLIGLLLDLPPVSRRGRALLGWCAVFILGNVAMGGGLAYQRWFEAEAHRRQKLRFIDFSDARTFAGPCVLYITYGALDAAWQGLAYWLLGAMCDRPRDAARFVGVYKSLQCVGGAVAFRLTASHVAPMRQFAANWGVIAGALLFALPAVYRITEPEDEEEFEAAQVQVNHVSELAQAQVAPQTQTQVERKDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9D8</accession>
    <name>K1V9D8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9D8"/>
    <dbReference type="HOGENOM" id="CLU_738078_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9D8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="375" mass="40486" checksum="30469AE611D9D0BF" modified="2012-11-28" version="1">MFNRTIRTLYTTARVLAEEADPKAAARSLGFSNVKRTRQLPALDIPTTGGADLFGAGAGPRPPSDGSERRPRFNGPRDGQRDRRPRQDGDRRPQGDRRPRQDARPPRQEGDRPPRRPHQDGDRPPRRQEGGRPARRQEAAADAAPSAPASAPATEAGSDFFEGIDLATMSGDAAPTRAPRGDRAPRGDRPPRGDRPPRDFQRSGPAGGRGGFAARGRGGPGGRGGRGGARGGRGGRGKGEYKSKEQLLEEFRNMRITMQGSATVPLVTVPEAGSPYDLFGPRSISRSVPTGYTEKEIEGMMQLTGDKRWKVEQTTLLARLGDYSLFNGRIPETVAGPHGAAQRVKFELRKNKAYDPATQAVPAMKIVTDAVGVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9X5</accession>
    <name>K1V9X5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9X5"/>
    <dbReference type="FunCoup" id="K1V9X5">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9X5"/>
    <dbReference type="eggNOG" id="KOG1793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045275_2_2_1"/>
    <dbReference type="InParanoid" id="K1V9X5"/>
    <dbReference type="OMA" id="QNAVERM"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="227"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="414" mass="46908" checksum="67DBAAAF83FE714A" modified="2012-11-28" version="1">MSASPDTNPIETAPSPGTPTHEEDVAVPADEGAQEEETGGEPIDQDAPATENPTEEGGEAEGETYVPATETTEARIPSFKKRSSAGAGEGDDTDDDDDDDEDRRRKKKKSRKDRRREEEEEEEVEPEMDEATRRRLALEERIDAIGKKQRVVRRKKRGGEDVDIVDSYHDEICSRLRDRMEKAAERDLIANQNKLPATSKLAMLDEVVSVLQNTTLWSSIIDNEVLKAVKKWLEPLPDRSLPAVGIQKAVFEVLPKMELDTPTIREAGLGPVILFYTKTKRVSPQISRAADALVQTWARPIIKRPADYRQKKIVSARQLDEEEEFDEDGERARKSRSGSQQAPKAKRFNVRQALSENEHRKGARMPIVQDVQYTVAPESRLQHHQEDLQHVARLQMDNKKFNRFARQFKTGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAP7</accession>
    <name>K1VAP7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAP7"/>
    <dbReference type="HOGENOM" id="CLU_1741862_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAP7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="178" mass="19575" checksum="9DE100118EC24B9D" modified="2012-11-28" version="1">MKSTSPSSRTQHARAQVWVYGVLALVALGALGVSVADIAVSRVRQQRLGGEEYYPGWQHLIMTAVWAALLAPQTFMLHISSVLIDTPPRHRADPSFIVLATHKRSPLNRIRVDLALLAFFFLLGIAPLTWWGMATRQWFEPYGDDLVLWGSLLGQPSMSSYRDSETGSAPSPSGVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB19</accession>
    <name>K1VB19_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SDE2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000399">
        <property type="protein sequence ID" value="EKC98025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB19"/>
    <dbReference type="FunCoup" id="K1VB19">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VB19"/>
    <dbReference type="eggNOG" id="KOG2827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060603_1_1_1"/>
    <dbReference type="InParanoid" id="K1VB19"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="10">
        <location>
            <begin position="69"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="24947" checksum="819E3751CE837FEA" modified="2012-11-28" version="1">MRVHLRLPSPLGTQVLHVDGATPAGELLPFDSAYLRTRTRLVSLDEPVGGLELAPGFPIDIDVVPRTLGGKGGFGANLRAAGGRMSTAKTDNTDSCRDLNGRRLGSIKEAQKQAELIESLPALRAKAAAESTAKLEALERKLGVSSGGSGEEGAKRLAEVDLEELARKKHKFEDDKFIDETREIKENVRSAVGAALLKKRKKNKDAAGKGKEKAAADKDKMPPPKAKPAPVASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD46</accession>
    <name>K1VD46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD46"/>
    <dbReference type="HOGENOM" id="CLU_1023736_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD46"/>
    <dbReference type="OrthoDB" id="2830113at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="29689" checksum="D85BA0F1928EB5EF" modified="2012-11-28" version="1">MLSTRPSRRSHAAALPSQALGQHNIFTLPPSPRPGRRTVRRKGTVSPPLTGNDRRRSSVSSGTPSICSTYPSPPNIMLNSPITANIKTQADLTNHYRAYLRALNTRTFDLVGRYVAKRARHNGYTLSHTEYCALVPQGATYTPEDIVADIQGRTIAARLSVEYPVNAPISSTLANSYGHQQTGSLSSTAGESLCDNCSASNPPTPPSTGTGGRSPRVCQVDEMVFYRFDEDWRIVEVNSMVQPRRERDAAKSQSGHERGSSRGLTHARSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDS6</accession>
    <name>K1VDS6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDS6"/>
    <dbReference type="eggNOG" id="ENOG502S445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_883353_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDS6"/>
    <dbReference type="OMA" id="FTIYATI"/>
    <dbReference type="OrthoDB" id="58379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="315" mass="34801" checksum="6F9A9D60A996F21C" modified="2012-11-28" version="1">MGLFSSDKKYPVPPDPTGQPPASNPPPPATYTEQSPPGYHQATSSISSSFAGPSGSSTSGGFGGGVGYTASGYPDEKKQPLEAAAPTPSMPIYACMLLSSSDKLRLLNFPHSVWDAIEQTIIRAWIGIQRKKMMDNSCIEFKLRGNPWYGQYSEAVPSRRLMTHLLHCLSVHGWHLSISTDLSKKSYDKDTLFFRHGPPLNRMFFSVSFNEYDKIRIIDPPTEQIKNAFVQAVQSWPLGIQRTETKEHGCTQLKLRGNPWMTSDGVEVNQARLMAMTIMTVMDQHGYELAGSVDMSASGGEGTSDRERVYSRQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDW1</accession>
    <name>K1VDW1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDW1"/>
    <dbReference type="eggNOG" id="ENOG502SWR3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119884_2_0_1"/>
    <dbReference type="InParanoid" id="K1VDW1"/>
    <dbReference type="OrthoDB" id="417158at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="157" mass="17611" checksum="99BD2E36C4F6665D" modified="2012-11-28" version="1">MSYRSNPNPNDIPHARPLLHPSVVPSLEKWHQMVETSDLSALPSIVHADAVFRSPMAIHPYESRAAVVLVLSTVVTIFKDFTYYRTLVSPDGLSVILEFSANVNDKKLKGVDLIRFGEDGLIREFEVMVRPLSGLQELGGEMGKRLREKLPKFKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE58</accession>
    <name>K1VE58_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000413">
        <property type="protein sequence ID" value="EKC97336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE58"/>
    <dbReference type="HOGENOM" id="CLU_2401243_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE58"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="93" mass="10051" checksum="88EC15D08A59759B" modified="2012-11-28" version="1">MCEPSRELCQAVRHVSAIARPRFSKVVLGLVTLSACSPPADPISPAREVLAYLLRSYATTLNGSLVYNLLVDLAPKHGGGEHLFWDEVYAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE95</accession>
    <name>K1VE95_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE95"/>
    <dbReference type="eggNOG" id="ENOG502S7B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373469_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE95"/>
    <dbReference type="OMA" id="ETHRNIH"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="464"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="744" mass="84235" checksum="CD96E10EC7142BC7" modified="2012-11-28" version="1">MSQRHSDGTPSALFDLTGTTDDSSSDGDYGPPPTLPSLKPRRTPISPQYESDDEDYINGILLAPAVNAPDEGKDTDDNMPLPKPSQRRRRVLAHSDEDVGPDIHTVDPQSSSPLWDKTGPSLHRGAAQWTGDNKSESGTVSWDRTGPSLHHSSKRSREQRKSDTPSWDKTGPSLHHQSPRAKPASKMEPFAEHRTGPSLHQPTSLAKAKSETPFWDKTGPSLYKPSAKGKGKAVDDGIGWGNNRVAVVIETPKSWFERQAEARKRAGVSVATESSVMRKPVRRRIVEVVIPVPRKLEPLSDLDSDVSLGEIIRKAPRRSKAPPKPARRRSPSFIADSSDDDEVVFRRKKVLTKKRPRSASKEKRIKKRKDKRRSDPDSSGSWTEDDDGAAMIELDEPERFKTASRLRETGPTAFQAKLKALGKLRDERDKGTQYASVPVELPTSESGSEDDDEDDSDESMGSSDFIVEDGPGNKAVQLPEEFTVQKQPWQYKFKVIFQYLVLLVVKGEDVLPLAPKDAAYFSRPVREVRSLFTGIRNSVAGQVWPAKYRKSLEKYPRFNWDQLKKPREFCSACARHKQRCFKSAFLGGEPYRRETHRNIHDSDDSYSTSEDEDYELGYLGNVCFQRTKYFHEVAHWEHQMYLRIRSRYHDLLRAKGKQETIETSSDSLRSGSDDSDGGRAERNVARARSEKRVEALRRGELPKNVRDPNEVTEWFDRTGFQKNQLHWLNALETRGKELERDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEC8</accession>
    <name>K1VEC8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000290">
        <property type="protein sequence ID" value="EKD02360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEC8"/>
    <dbReference type="HOGENOM" id="CLU_1225525_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEC8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852058" evidence="2">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="23551" checksum="A166FE4E1B7DA1E3" modified="2012-11-28" version="1">MRAALVATAVLAASAHAQRQHTTQDELPADRNFKTDNTSLATRSRTVYTYPGAAGADEELTTVPTGRHTTTLWDFNGDPVVTTWTGTRIPTLSTPAEEEAPTTTSTKEAVDDAGAGAGGAQGGNKGIQGPPTTTYPPMTATTYGYKNQAGDWVTTEWTQSWTAPAEATAEVSQGTIQGMQEYKDAQKSFTDKAVQPGSAKQGSSSGAERVAPGAAALLAAVAFYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEI4</accession>
    <name>K1VEI4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000285">
        <property type="protein sequence ID" value="EKD02425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEI4"/>
    <dbReference type="FunCoup" id="K1VEI4">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEI4"/>
    <dbReference type="eggNOG" id="KOG0601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278508_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEI4"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="793"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="822"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1135" mass="121763" checksum="010718D31A30E468" modified="2012-11-28" version="1">MQSLPIDTPSTTPSRRPSPLLFEPHDRTVQSLLPPSPKRARASPCSQPMHRRVTPTSTRKGVSRLSPIPCTSVFGGSASYSSASTVPARRRTGDDLRRSQSSSRRRDMTVPLLSQTFSSVTLSQTATPPLAPDLSPDASFRSTSSAGLNMATPVTEAGSPLQSSRLKLRTPAALHEMTHSSSTSPMPAINSLLGSPFNARKPLPFEFSIASPTWNHGKDNDANLFADGWDAKSSSPMDMIGGLSPCLSKPYHYHSADEGSGSCTSASSSSMFSPENGIGSGARPSVVSLWNDDSGDEDVPPAARTKLFVGRSLKGKKSATRLKPGPASPLVMSCTTNNTFSSSPDSSPVQTTFLSASTSAVEGRSIAGGLQSPVEDYFSRRPQSARKRTPNDRFASSPHELFLSQCNSRGFELTPRPDGPRTPVIPMSDDIAESDHSPLRHNAAAVHALPLSPSAPLLSRRPEGLQLHLTPRNHSPVGVTRSKSNRGARSLPTRPTLRRGLTEPANKTPKAPPVPQLGTPVSELFGDEKPSPAAFSSTGLVKKRGARLNIPRFAAKLKAPQPLSFDDKPKTQAAASAPTSGSDTETDDSEGDQLSPIKPLRSGPFRMSLNSTRTHSRNGSLASDIASSPFRRSHGHARMSSTASSIGGSKGLRRKSSAMFTSAGSIASDTEFSPATPTKPLPLALQQQPMFGISTPSPVSATHYPFSRRSSVASMASMDATSPACTPSTGPGGRVRALSRGLAARLSNPIPSTSFRTQPPFMPTTPASVSAAAEGYIPEDARAAGAGRLERDFTLVQALGAGEFSSVWKVKHKGDGKMWAVKTGRPYTGVKNRSRQLEEVAILTRLSEQPHPNILRFVDSWEQGGRLHIRTELGECGDLSRYLLSLGDQRGLDEGRVWKVMAELTSALDHIHSNGILHLDFKPSNILVTREGALKVADFGMSVFRDTGFLSGESTRRPSPTLPSFGEDADQYNDHLAITTNKLLGLAPSPIMDREVEGDREYLCPEALDDATPGTEADVFSLGILVLEAALNVCLPSNGEAWIKLRSDDYSDLDEHYVQREQVVGTTELPVVSGRLLTTIKQMMLSSPQWRIKLDEVLALDPVVRAAEAMRGEGMWQASPALVEEEDGWLDWLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEI8</accession>
    <name>K1VEI8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEI8"/>
    <dbReference type="STRING" id="1220162.K1VEI8"/>
    <dbReference type="HOGENOM" id="CLU_525987_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEI8"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="56976" checksum="942BAB8918B353C6" modified="2012-11-28" version="1">MTANVARPIPQRQPSSPVTHSAPRPIPAANGRRRSASASSSGSHNGSYKSSSLSQFVDSRFLGSCATTTPFSFLEEEEEREAESEASSPPLAASLPRPSSSPPSPGPLNGSQNSPPTASRSPVAATHGTNTPARRTSSKRWHRLFDFDHVLGALDPARLASATAPDPIPIAVFGAETEEGIALCRQLLAARCWALVALMVDDSGPEANELRAANVPVIQVDMDDPTSYGKHLMNMRAVYLSTNGEFSSAPIDLRSAIRSRTALMCQALGMELTTVLKLHAILQHQPEPARTQIARQADACQLSKALNACQEAKVGHVVFRVTACGQEVVEGVLGRPKKVMEAQAELWKRGIAHTVLHTTVPYGRVREWLRRDGDRWILECPIPDDIKMPMYALEQTGLYVINTLKAHLCSKQRRYPGEDVHAIGEWLTPLEIAKKIQKISKIPVDTAHVSLAEFASLETHERLTVRWDAWNQLITGEYQNEYGEYGKQTRSAITGVDQMTFDEWMSQDPEIHRMMKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF55</accession>
    <name>K1VF55_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF55"/>
    <dbReference type="FunCoup" id="K1VF55">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VF55"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043453_0_1_1"/>
    <dbReference type="InParanoid" id="K1VF55"/>
    <dbReference type="OMA" id="WEDAYTH"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34396" checksum="29398DB7A6F15838" modified="2012-11-28" version="1">MARNSEKAQSMLYRFREQQAIEMGMGNRVAGGRRPRVPASVSSLRDCERWRGDVMKEITTLTDYEIRDLNDEINQLMREKRGWETQIVNLGGANYKRAQTAMTDDDGKEVPGTRGYKYFGRARELPGVKELFQKGTATEESARNASFQMFRNQGPDYYGDNDEMDGNLAAEEDEAQREDWAKAARAAAEILSLGDETAPPAYPSVIVSRPTGEPGEASKRKSPEPEEAEPAEEGSSKKKGRGAKKGKKAKGGDTEKAQDAAPAAQAAQAALAADFMSVFDPATLAAPVLPNKEELGKILLERRKDALRAEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFQ4</accession>
    <name>K1VFQ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFQ4"/>
    <dbReference type="FunCoup" id="K1VFQ4">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFQ4"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_1_0_1"/>
    <dbReference type="InParanoid" id="K1VFQ4"/>
    <dbReference type="OMA" id="WESEHPT"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="508" mass="53924" checksum="3FAD9E16FF562CB2" modified="2012-11-28" version="1">MLRATLRPSRSLRPLASAASAATASGRRATHSSTPKRSAAAAVQQPSVPSGPSGPSGWAQATQNAHNILAEGAAVEDPLFAIKGEIGELKASLFQMLGSSHPSLDAVAKYYFKAEGKALRPLLVLLMAQATNGLAGRGWESAYARAAEDQRLRSGGINRAVTEMGGVLNDWNPESMGLEPRGRMVFSEPFRITRSEAGTQDQLGGFNFLFSSNQPPNPPEVTHTKFADILPAGDGKVILPTQRRLASICEMIHVASLLHDDVIDASDLRRGAPSAPAAFGNKLSILAGDFLLGRASVGLARLGNAEVTELLSTTVANLVEGEVIQLKATTKPAESPTQAGFEEYMRKTYLKTASLMAKGARCAVILGGCGEGSTRDAAWIKDVAYGYGRNLGIAFQLVDDMLDFLPASADLGKPGSGADLRLGLATAPALFAWEEHPELGPLIRRKFSEDGDTATALELVKNSQGLQRTGELAKYFANEAKELIMLLPPSEARDALVDLTIKVVDRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFY1</accession>
    <name>K1VFY1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFY1"/>
    <dbReference type="HOGENOM" id="CLU_858388_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFY1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="324" mass="33501" checksum="BF7DDED71F8784E9" modified="2012-11-28" version="1">MAAVLGNIGQPRTNGNRHLVATWDEDERAIRYTRSEGTRLDGSPLSPSPSTPLVTKLLAFALADDSLGVSRRTSPITEALEPPEGEQPQPEALGPIPDPLYEEDAGAAAEDSGESRDEADNGTDDSGTESGSVDSDDGKEGMSSNHEGITAELPPSSLKLNSSSGETFGPSPLPSDLPDSLGPSSPAPTGLVDRRRTRAYAVAEEAGAGARAAANLDAPLAFSDPDTPTSGDTPATHPVTPTGIPTNRHYLPASEEAAYSSAPSVSPTPVAAPRAASATEASSPAPETSPTPAAHGPTDALRSRLVGRSRPDMLPPRPKRWRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGR0</accession>
    <name>K1VGR0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258637_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGR0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1337" mass="149759" checksum="AF3E433F6F05AB5A" modified="2012-11-28" version="1">MSSVAQTDASRKVVDISPRSLAQGKGPPESPWFHVSDVDLCPDNTICKGIRDIIDGGCGDDTIARLSNYRGGYFFCACRTCRKTRFVTGTPFILTPELDQSAVGRLFPHHEWPFDHQGGPGLVHWVARRLQEHYNHHHWISSRAQFPLPGQQERDHTQDAPRSTNAFDPRVRESTDEVSAPWIRLIRYQLPEGDPPTNLMAKWLPYLYRGPVPEGAYRRFPPLNCALMTMLSEPEWRETATLQLFGTFDQCDVEILVNYSADHLSSGTDRASSDRPELKVHLLKGISGLTVLFLSLVEPIPVIDLLTSLNSGGPVVTDLLRCFGTPMLPEDRPLKRASILSPTSRALVRLCRSSFLSTSPARRFSHRIMQLMQIWLSRPVIALRLSRSVTQDQDAMAELQSLFRLPFGFIDHESKGQVSADTFQAYLSQMGIFYGCAIAAVSSATFTPSPHQLLREETQTDEPTVRKVSTVTPADSMAGRTCSRETASRHGNAEASPNIVASIESMESQKPLGRLTMLLLSLREGVMSRIEELQVLDERISDHFKVGHGGVGFYGHLARTILELLPDEGHKAQLRSWLAASNNQAYLRCLSPPRRRSRSTDLAGPVCTVMAQESTERGRVDDSVIDSTLSSSLSHGSGPPDSPWFFVSEFFFDWLQLIDTCLERPITPRLQRLVLRQYSGNTFAHFIGSLLRDFWGIIASLSHQSIGCRCPQCCRIIPERGRSQGPTIFSPAPPIETTAKLLPHLDWPFDHQAGQSGIMEWVSKRLEEFIAVTIRDYAYFTTADVKSSQLLGIKRVTTLVGEPGPFPQCLLWRPRRFKLKLNDCRPPTAVFPSESFKWLQYLYQGKVPAEWHSRFPPTSHLINTLSTEPRWSCCEARALFVNFHQCDVEVQLGSTVTGAKKCFSLKGINGLTVLFLSVSPFNSLSSDSFRYRMLACPSCGSIIIGDLARHRVHLPLLYLTTGGLYRELEASVVYCDNHSSFEIICRHVVALHQLEAEHLLHFYGRLRPALLREDSVASRGMQTEHATDEGFRQLRLCAMRRGCHAALTVITVVVRTEQQLSPSSRPNQPVLSHSGVVASLTNSITEVLLAGFKIAPANALKQALKQLFQRRLSRFSYCDAISVDEKLKIAKRWQMRELESYGGLVDGEMFFRYFGHAAIITFSAAEMNSDFRAVLDWFGDLDANAMKQTIPFGHSVWVPGLADKLLFFSPLSPPYLAPLPSRLLKFPLTDEERDLMKQHELYLRVAAVIPARQRPWYASIVHHALGYRSPRLLAFSDANSLNVKNARFSSPRLSATTRIIHQVPQFPKAATLALVTIALLVLKLWSFYPSGAASSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGT6</accession>
    <name>K1VGT6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGT6"/>
    <dbReference type="HOGENOM" id="CLU_1094941_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGT6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="210" mass="23280" checksum="B50D8DC8F043A086" modified="2012-11-28" version="1">MSSNKHPYAPSEDDSTVKLLDQAETDESAAVQPVAEHTPRPSIDYYVCVPVWIRAVPIIAFVTGQAAATVLVTLITLCFEEGRKRFGTADLVLILLSVVELAVFAFLYRLSYVTPITGPEAAASYDPTRARFQYVITLSGNPEIHPLLFFVYGWGIYYSFSEYGPIAAIRSLTFVCIALSMGLLIAMLRKRPLRRLYPGLPLYSRPAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGW2</accession>
    <name>K1VGW2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGW2"/>
    <dbReference type="STRING" id="1220162.K1VGW2"/>
    <dbReference type="HOGENOM" id="CLU_444954_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGW2"/>
    <dbReference type="OMA" id="NDNSAWT"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="614" mass="65796" checksum="DF3D93D30951D016" modified="2012-11-28" version="1">MRSRPPSTVTPPERHNMECAQLGYSSTEREPDRPRLPRLPPRPSGQSPKRPSSLRTPSPSEPEEEIEAASDTLDPPAAPQRRSKRRANISAASNDNSAWTTNTNSKYAKTRTTRAKRPAGNAPAATQDDTPIVVKPTRRITRRQTRERFPEPEEPAETAEPAMPMVAGMAPEPTGIPPRRPILRSRAARAAPVSDADDAPVRPAIRRAKRVSFYDAGVEETTEVETGLETPSSADESQNAEATPTKTSKKKRKRSSTYTTLEAADSPKSSKSPRTSPITNAAVADASTSEPTAAPGVPVEVEVGAAPPTEKVPTTPRRARRSLIAPGTPSTPVNATAVDNAVTRALALRGFAGSQVFRSSSQASQSDSSAEPEPAAPLEPAQDEVAMDEDAVSSPTPSESEPESPPVPAMESSGLTPQSPMPGSSATSSSGSEAEDGWDSSSSAASSASSNTDPPMLLNGTELERTMSAIDEAFVAPVVPLLHLPLPVLVRPMPAPVSGEAAQLDRDSSADSEERVERAVQDRAVQAEAEATAEPNVEPSAGTTPPPTETIAEARRRYSDLTREFDALHRELEAERARVQGLREVRQQRTQLRRENQQLRAQIMTLEQRLTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGZ6</accession>
    <name>K1VGZ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGZ6"/>
    <dbReference type="eggNOG" id="ENOG502S8YZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGZ6"/>
    <dbReference type="OMA" id="HEDFVWK"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33203" checksum="D093F88FF183B465" modified="2012-11-28" version="1">MTITSTTGIETKKPQWQHDLERDGYCVVPGVVDAAACRAFEESAWAWLSGFGLGFNVNDKSTWTAAHLPSSAFGGLYYQHSVQHESFVWAIRTFDGINVSLPLGPQGQRDIQPTKPWPHIDSDPRAPFSLYQGIANLAPNGQKDGGLCVLRGSHLLHSQYPAGFDGPATDAHRFTEEEFEWYQSQCETVKVCADAGDLILWDSRTVHWNCSPVGTQPRLATYVCYCPRDVADEEAMERRLTLWRERKGSTHAPHKGLMARGQEEPPRRLDGSEGGWRTVPKKEAMETPEVLALVGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHB6</accession>
    <name>K1VHB6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60s ribosomal protein l7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHB6"/>
    <dbReference type="FunCoup" id="K1VHB6">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHB6"/>
    <dbReference type="eggNOG" id="KOG0398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_1_1_1"/>
    <dbReference type="InParanoid" id="K1VHB6"/>
    <dbReference type="OMA" id="HINCYVE"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="5">
        <location>
            <begin position="199"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="310" mass="33831" checksum="12C51FE82A7B3D0C" modified="2012-11-28" version="1">MSLRSAVHSAASASRVLRPSAPSVLVPARHASSSTKTQDTAAEDWVVPAIHLGPTHPSRYGEHYAQTLETDMMYMAYNHRANQVYAAEARKAADKAAQPAPMLTGYEANRPKAMPRGNRPERPLNRPITPELIPALESITIHSMVKEAIGTKQALLDAIMALRAVSGESQKGAGRMNEGVQVLRARKSAAAWKLRQGMPISTKVEIKGEPMYDFLQSFVEFVLPRLRDYPGFKLPGVSSNKNTPSAISGVVAMGLPPAAMGLFPQIENSIDSYPRLHGFDIVFKTNLRGADSQEFARALLSGFRIPFSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHX5</accession>
    <name>K1VHX5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHX5"/>
    <dbReference type="FunCoup" id="K1VHX5">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHX5"/>
    <dbReference type="eggNOG" id="ENOG502RXUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHX5"/>
    <dbReference type="OMA" id="DYDRPMY"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="332" mass="37452" checksum="3F8766E8E043874A" modified="2012-11-28" version="1">MHSHHSHSGQFCRHAKDNLEDVVKEAVRQGFTTFGLSEHAPRYREQDLFPEESDLTPTDLSRIYLDFLTEALRLKAKYADRITLLVGIETDFISPLDMSELTTLLSQHEEIDYVVGSVHHVSGVSIDFDRPNYLRAVADCASPTPTMVRNAEGELVMAPPVNEIKEPETMADIEDFVARYLDAQFEMIIAQEPEVIGHFDLCMLFTPQISLKSSAAVWEKVERNVDAAISYGALFEANAAAFRKGWNSSYPAPDVLQLILSKGGRVCLSDDSHGVSYVGLNYGRLREYLVAQGVEEIWYLVPRDQEGEKVGKRGRVKAKPLRGWERAEFWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIA8</accession>
    <name>K1VIA8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_01883</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIA8"/>
    <dbReference type="FunCoup" id="K1VIA8">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIA8"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
    <dbReference type="InParanoid" id="K1VIA8"/>
    <dbReference type="OMA" id="HETTWGI"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000277">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="469"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD03870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="700" mass="78293" checksum="7C6F2B4B61EA28C1" modified="2012-11-28" version="1">MHGDGRAAARLALLPSSLARLGCRPDLLRPPLRGLAFLRTTLASTDDPRSSPSSPRSRFRRKSPRRMSQQALSTRAHLLSQLGRAHVICLVYSISDPSSFDRVAEYWLPLFRKEGINVPVILVGNKIDLRGGEVTNQALEEEVAPIMREFKEVETVVECSARLPLNVSEVFYFAQKAVLHPTAPLYDSREHILKPKCLEALKRIFKISDVDKDGLLNAAELNQFQQKCFSTPLQTQELEGILNLVRSYDPASVQPLPNTPMAQMNESGVLGWSQTAQDGWPQISTPQGQLSPSAEGLTELGFLYLHTIFIQQGRMETTWTVLRQFGYGESLDLREDFLSPRFDVPYDCSVELSPLGNQFLTDIFEAYDKDNDGALSQSELDDLFSTSPGNPWLSQGFPHTTITDDLGRVTLQGWLAQWSMMTLLDPKLTLNYMAYLGFSSSPASDMPLVASVKVTRPRKADRRAKKVTRNVFLCYVLGATGSGKTSLLRSFVHKPISGDDRSYEPTTKVLSVVNSVEIDGQEKYLVLQEFGSKYESEMLINKKKLELADILLYIHDSSDTNSFSYISNLRQQYNLDHIPSLFIATKSDLDLAQQRHEVQPDVYCRRLGLPAPLAVSAVSGPLPNLWVAITRVGLNPTSYIPRGPRSDSPAKRVAVYTLTASSIMAMAAVWMRYQGYTFRGVWGWVVRNTGMLLGWTAREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ00</accession>
    <name>K1VJ00_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_06632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ00"/>
    <dbReference type="FunCoup" id="K1VJ00">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ00"/>
    <dbReference type="eggNOG" id="KOG0436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_0_1"/>
    <dbReference type="InParanoid" id="K1VJ00"/>
    <dbReference type="OMA" id="MDTQAFC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="53"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="201"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="418"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="556" mass="62267" checksum="D371AFBF81A4343E" modified="2012-11-28" version="1">MRLLVPRMAVVRLQPRTVSPALRRWNSTASSKTQQREPESFFTPAPGDDKPFMVTTPIFYVNASPHIGHLHSMVLTDTFARFSALRHPDRPVLFSTGTDEHGMKIQQAAAKGGMSEKEFCDEVSQRFRNLADKAETGYTDFVRTSEERHYAAVDAFWARLMASGSVYKGTHEGWYSVSDECFYSEQQIEKADDGKMIATETGNEVVWSEEENWKFRLGDYKDQLREWLQRDEAVHPWPMHANIARQVDGMGELSISRPASRVKWGVPVPGDPSQTIYVWVDALINYLTVAGFPGEMPAWPADMHVVGKDIIRFHALHWPALLSAAKLPLPKRVLAHAHWTMGNAKMSKSRGNVVDPIAAMDHYGPDAVRWYLMRSGGSLEGDSDYSAGELSKAHAKLGAQLGNLVQRILAPKLLAGVGESFERDADMDATLSVLPEAIERRFEGYELTAAVGALEAALADANRFFSDNEPWAKTNTTREMAYAYATLRNVGILSRPIIPGKSEELLDRLGVPADERGWKDAQWNGELDVVEMKRRLEEAGKKFKGTTLFPRIDDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKC3</accession>
    <name>K1VKC3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000418">
        <property type="protein sequence ID" value="EKC97227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKC3"/>
    <dbReference type="HOGENOM" id="CLU_065431_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKC3"/>
    <dbReference type="OrthoDB" id="10676419at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="367" mass="40557" checksum="515B1B53C9F599D9" modified="2012-11-28" version="1">MSTSSTLASGPEPIQAQLLPSRPSASIDHRFYPHIIDNIFSYLPYPGLIICTQVCREWREKAKPFFKHIAIFEHGAGGHNRTVVRSRDLSFPGMSAVLLYDAFPGADGVFSPARVKNSGALRERTTIDGYFSISELPQARGPRSQWPTVFYRLLNPSIRDRDFSDFLSCCFDGDDVVRFADFSQGNFLLAGQCPEAPTTLALTIDCYTNPSMPCADTFSGLDSLRDDFRCLETLTVVLMDCQDVANPAATMIAATGPADKATAQRISDGQSLGATNLGAACELLFYISDTAAVDELAVVGLEGFVPQPDYLPYLNQLCSALADEFGHDFSSVTEDTVPSLGRFLKFYTHQQYREMVGRERYRLLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKH4</accession>
    <name>K1VKH4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000217">
        <property type="protein sequence ID" value="EKD04640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKH4"/>
    <dbReference type="HOGENOM" id="CLU_464755_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKH4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="587" mass="64069" checksum="F081D05138EB27F4" modified="2012-11-28" version="1">MVVSSAGYTPRVVSGASTSSSESNAISATSSSDTNITVPSCTEEESKEEPGCARQVGIETETPQSIAEDASGTFTFLRCPAPAITRELLRLPICHHPRRMALWAAHIAVLRWLEAEGEAFEASEGGIDAPTELKVGPDVFAWAVFKCVLDMHSALQRGERASEKRSPLPRPWREWVHLTDAMIDRALALAGQQHVETCTPTPLPSEAFVFPRAHAEEQVPTFPPRCVAAYAAEWAARLATEAWAAAQQVGRLAEISDTIRLWAVVDSVLDRVDTHRARMVADRYSRDAQTPLRRLRSWDSWIYITDDMIIDAFEAAAAAQGLDSDTEEALADLKRVGRVARVVVDLTWEASDSRFPPREYELERNIDPALYGECDPFAVPVRPVRPVRPVRPGPRGVMTPTPSPQTRLRPGNRPLLRSTTSARTTSTLPGRMTSPPGRTFTPDTSTSTRARSKHIGVEAPSGCKKERAEGMIPLSHRCVRVSHQLQESYARVCGKEVDERGELGLGLGLKHRGGRRGELIACGGADIQPKKTAKRAKDDPDSDEDEKPPKKSKPASKGKAPSSKAAEAECGQLCAMAPTVLWEGECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKK1</accession>
    <name>K1VKK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor beta propellor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKK1"/>
    <dbReference type="STRING" id="1220162.K1VKK1"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076798_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKK1"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="5">
        <location>
            <begin position="219"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="319" mass="34961" checksum="95035C841C019F37" modified="2012-11-28" version="1">MASAHPRSKVSWCRRRTLVRGLVQDPFAIVYSEDGKWIAYALANTVQIVSSSSGEAVTIEQPGVVALSFSPLASTLYTFERPVKSETDVYKNVKAWSIKGELIGGWAPVITPDEAHRFQPAGNDILIFSPPLAPRPATRLKNDGQIRGLFLSHPAELPEGCTSARSVRPYTEQAMAVWVGERKGAPANLALYPVSSLVGKPASADKTENREMPITVARKAFYKADKLNVKWNNAGTMVILTPADVKLTVQALFLTHTDVDNTGKSYYGETNLYLVALDGSFDGLVDLDKEGPIYDFSWNPTSKDFCVCYGCEFCSPWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKK6</accession>
    <name>K1VKK6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKK6"/>
    <dbReference type="FunCoup" id="K1VKK6">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKK6"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_1"/>
    <dbReference type="InParanoid" id="K1VKK6"/>
    <dbReference type="OMA" id="MIMGWMM"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="195"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="459" mass="49992" checksum="BE58C8C012FD8F3E" modified="2012-11-28" version="1">MAAPATVPTNPAIEPEFEQAVQEITTTIEPFLAVHPEYRKALEIVQIPERVIQFRVTWERDDGSVAVNRGYRVQFNSALGPYKGGLRLHPTVNLSVLKFLGFEQIFKNALTGLSMGGGKGGSDFNPKGKSDAEIRRFCYAFMLELSRHIGADTDIPAGDIGTGAREIGYMFGAYKRYRNEFAGILTGKGDDWGGSHIRPEATGYGLIYYVTEMLRDLDNTDWNGKRVIISGSGNVAQFAALKVLELGGTVISFSDSTGSLISADGQGFTVDDIAAIADVKLKRQALTEFDHSGRFEWHEGKRPWTLFESADVALPCATQNEVSEEEAEGLVKAGVRYVAEGSNMGCTQEAIDVFEATRTKIQDAANTEGICWYAPGKAANCGGVAVSGLEMGQNSQRLKWAAEEVDAKLKDIMVNCYTNCRETGKTYVKDSAVPSLVAGANIAGFEKTARAMKQQGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKR5</accession>
    <name>K1VKR5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKR5"/>
    <dbReference type="HOGENOM" id="CLU_1215543_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKR5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="216" mass="24526" checksum="E2AE5AB1E87D9690" modified="2012-11-28" version="1">MVSTRSRTYPPTDAVAATTSGAAPRRSSRRPRSPSKQDAAPVPEQPSKRPRTQSPAREDAGPSSPPARHRAPRRRQVFPFDESDSPPPSPSAPSGSSLPLSHQVETNQKIKRLEAKIKVLEREARYHEEMSKRWEKLSSHLLHEREGEDGYVHKLKRRGDTYKKAYLEEKEESRRMVEATKYGIICVKKALEKNPDHILRGTLKVLEMSLPYDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKT9</accession>
    <name>K1VKT9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKT9"/>
    <dbReference type="HOGENOM" id="CLU_1490024_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKT9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="181" mass="20439" checksum="57246CA6BF1BB9F7" modified="2012-11-28" version="1">MTRTAISDISTFQLWVWASVNRKEQSFAPQTLKLHAYDSEIVGVIGTEGLQLSRICPSRLLWRRARGGCVRSDGWSSRSSACKSWVRLLLVCPDPELYSSATAGDGSKSTIERPDRTSQPARAARRVYPGAVKQRHEPCLQQMDTRPTLDSRHEAMAGRRVHLWDECRPEIPMFSTDHLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKU3</accession>
    <name>K1VKU3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">A1Q2_04323</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20"/>
    <dbReference type="EMBL" id="AMBO01000318">
        <property type="protein sequence ID" value="EKD01376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKU3"/>
    <dbReference type="FunCoup" id="K1VKU3">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKU3"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="InParanoid" id="K1VKU3"/>
    <dbReference type="OMA" id="MTPTRIH"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="21">
        <location>
            <begin position="199"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="409"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="593"/>
            <end position="596"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="611"/>
            <end position="613"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="634"/>
            <end position="637"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="805"/>
            <end position="806"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="816"/>
            <end position="820"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="853"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="891"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EKD01376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="892" mass="98302" checksum="868D1D836E3BB6C1" modified="2012-11-28" version="1">MSQVDLVILILAVALPLLWWFRESLPFIGGKPKTAADAALKRGGAGADEEGDPRDFVGKMERGVSNISLSHWAICGKRWAEGVQLQAWRSEKAPSAITVIPAQTHRLLLPSSGPLAVMSQPAGSAVRRLLAMSNPSCPPDAATRGDAEICRRRARRDARRPGRAWEAAEAAAQCNQCDNEPDLANLAAALLTCKQNKKCAVFYGSQTGTAEEFSIRLAKEAKSRFGVSSLVCDPEEYEFRNLDQIPEDKAVVFVMATYGEGEPTDNAQQLMEFLEEEEPEFSNGSTLENLNYVVFGLGNKTYEHYNAVARKLDERLTALGAKRIGERGEGDDDKALEEDYLAWKDDMWVAFAERLGVEEGGAGDVADFEVTEVGEDVPANKIFHGELSPRALVAAASGTTTPVGSYDSKNPYPAPVHTARELFEVGADRNCVHIEFDTTGTPITYQHGDHVGVWPSNPDVETERMLSILGLQDKRTQAITVESLDPALAKVPFPVPATYEAIFRHYLDISATASRQTVAFLARYAPNEAAKEKLTRWGSDRDIYAAEVDGARLTLGEVLQAAAGDKLTDNSNVTKWDIPFDRIISVIPRLQPRYYSISSSSKMHPHSIHVTAVVLKYESKPSLAHESQPRWVYGLSTNFIQNIKLASDQTKSGDNLAVTNGHANGNANGHVKVGGLAGGVAGIELDGMPTYKISGPRDFHFRDNIYRVPVHVRRSTFRLPTSPKVPIIMIGPGTGVAPFRGFVQERVVLAQRAKEKNGPDALKDWAPMFLFYGCRRADEDFLYKDEWPKYQVELDGKLQMQVAFSRGPERKPDGSKIYVQDLIWAARKELAPLILERRAYVYICGDAKNMAREVEARIAQMLGDAKGGSEAEGAKELKLLKERNRLLLDTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLM3</accession>
    <name>K1VLM3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLM3"/>
    <dbReference type="HOGENOM" id="CLU_1210539_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLM3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854228" evidence="2">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="229" mass="23749" checksum="C84FE04E025B4904" modified="2012-11-28" version="1">MKLATTLAVIAATLPAVFGQGLSLDRPADNATVEAGDTITLSWTAWGGDQGQPPPSEAYFWISAFNVAGQNAWSISPDGKTHRVDDSQEALATVKPIDVSEGSLAVHIDYTDFLAGRADKKLPVRIMITQGNMRDVSHVGTKGQVYVNRNIMLEGLSPGETGVNASLTTTAESLLPVQTDDSGAKYQHVKGAEGHVNGTVDAKSSATRSAAVIGPLALVAGVIAAALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLX7</accession>
    <name>K1VLX7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin remodeling-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLX7"/>
    <dbReference type="FunCoup" id="K1VLX7">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLX7"/>
    <dbReference type="eggNOG" id="KOG2570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023529_2_1_1"/>
    <dbReference type="InParanoid" id="K1VLX7"/>
    <dbReference type="OMA" id="VMDSKHH"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="270"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="496" mass="55293" checksum="BAEB550561607F08" modified="2012-11-28" version="1">MAAPPPGHPQQHPQMAQQPGPVPPAPGQAPLGQVLKRPADTDVDAIRRLKHPRPPLPPPHILESLVPDSPAFTELMKIEQKLDWTLLRKKAEINDALGRSTRVKRTLRVFLSNTVHNQPWQTGSSGEKDGDVQMGEEKKTDGENKEGENKEGGEGEKKEGEENKAEGSSTAGAPPGVDVKTGNGVAGWVLRIEGRLLDTGNHRLDKQKRKFSSFLRSVVVEFDNREAPTFPEGNIVEWHPDPTAEPLDGFEIKRRGDQNVKARIILHLNHSPERFKVLPPLSDLISIREGTRAEIIQAVWQLVKTSGAQDKDDVTLIRPIGGLEKLLQPGAEGVQFHQIPELVTRYLAHPDPIVIPYEIDVSKEATFHPQCFDIPLEIEDPLKSKMATIVQNFEGGVGNEITKLEDKVGELAYFARDLKQKRDFLESFAANPHAFIQNWLAAQARDLDQMLGYQIGQSGVNGGSIREEDLRRSDIFHLPWVDEAIQVHEQQRAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM09</accession>
    <name>K1VM09_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM09"/>
    <dbReference type="STRING" id="1220162.K1VM09"/>
    <dbReference type="HOGENOM" id="CLU_434898_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM09"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="629" mass="68467" checksum="FE04AE1F2649AFF3" modified="2012-11-28" version="1">MDAHLDNVVDTLVGGGDVSLSSRDILKWSEGVSVHAPDLSAIREQTERSLDMRELNSALDEVGQELPRSTSMSTAHSNSQVSDSLALLALASQDKHYSEAHALTLDALEGRGPTPSSAAVNKPGSSAAGSADRSSLRDSLRDSVRDRVRDSVRDGLRDGLRDGLRHSMRQSLRESLLHSRRHSGDSNIVDEQLRSSPAQALRTSSNGRSSTSGLGASSFSTPPNTYRAHPSYRERLEKEVPLSLRKSPAVLARLSAQDSPALRHARRGSSPFLPPCAPDASMLDATFHPPEIGDRTYDVLETAVTTNMNRRKGSGLENLKALVAESAARLSPSTSPIATSFPSSNRKFDLRERSAATMDKSTFIRRVREDSESPLKETSLLDTKSFALTPPQERRDALAPLPSARATRYTTPSAPRFQQPDQTDRTVDLGRLVNRQQEASRLPGNDSIMGSDLADLSIDSQEEMVPASLRPRPLPPSSSMRNLTQQLDSRTITEQLREREQQRELARARSLANLTRASSMRSLDARSPRVERTANAEVPISKRREQSSAAPNPGRRMSTMAPSNGQRASAASRGPLGFPRSTVPRDLALGTGPSRMSAPATSFTKNRHCKYATLITWTHLLSTCRAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM34</accession>
    <name>K1VM34_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_05254</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM34"/>
    <dbReference type="FunCoup" id="K1VM34">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM34"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027974_0_1_1"/>
    <dbReference type="InParanoid" id="K1VM34"/>
    <dbReference type="OMA" id="IKFMMRA"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD00417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="35186" checksum="84213CF2E5FA964C" modified="2012-11-28" version="1">MRREMAPMPAIPRQSDFGIHEVWADNLETEFAALRAAVDKYPFISMVSYGVGNPADCQDTEFPGIVARPIGTFKTGSDYHYQTMRCNVDMLKIIQLGITLCDEEGNSPEGMTWQFNFQFNLADDMYAPESIELLKNSGIDFKRNQEDGIDVEYFGELLVTSGLVLFPNIKWVSFHSGYDFGYLLRILTCEPLPATENDFFRLLFIWFPCIYDIKHVVRSVKTLRGGLQEIAESLGIQRIGPQHQAGSDSLLTAAVFFRIRSTYFNNELDDNYYKNYLYGFSSGRSPRPPGETTKPPSPTPAAQLLGGEKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM47</accession>
    <name>K1VM47_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM47"/>
    <dbReference type="HOGENOM" id="CLU_083702_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM47"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32048" checksum="AAF2EEC470426DD7" modified="2012-11-28" version="1">MPPSLDPLFFPHIFETILLNSDRKTLLTARLVSRSMCSVVDPLLCGPFLELLTESDGSLGAWSHGRTGSIDSRRLPYFYRNGNESTRIAAMRQARGFGMHTSAASRYANSLLQHLPPQVRINIMHYDINYPLPPCAFATMPGDITLPACSYLQIIVQGCGNACCCQETAAFKHVSASVGICIEANYPRAHDMSHCEQSNCSVIAGIINPGVTELVLVGVEMGMLPCLFNGINVQANPDLQVRFRLYDRFSSSREERLAREAVKCFDVSESQVRFDYFNSCLSTPVQSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM86</accession>
    <name>K1VM86_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM86"/>
    <dbReference type="FunCoup" id="K1VM86">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM86"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_12_0_1"/>
    <dbReference type="InParanoid" id="K1VM86"/>
    <dbReference type="OMA" id="PIRIIYD"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="124"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="596" mass="67049" checksum="834B0C4331465127" modified="2012-11-28" version="1">MLTLQLLLIRPRSRDHPTTMSNELDAVVKNGTDGPKRTEKTYPQGMHPRLRYLQPYWWPYRTFCKQRWIGRQLLEVISTEFRDRSVDYYLRLGWLADISNTVHRHEPPITNDPVLVLHIDKEKDFVVVSKPGSMPVHAAGRYFKHTLLELLKTDYGINAFAVNRLDRLTSGLMILALSGKTSSRLANEFKEGTVKKEYIARVRGKFPEGDIVVDQPLLSVDRQMGLVIVAPQGKESKTIFTRMSYDEKRDQSVVHCKPQTGRTHQLRVHLQWLGYPIANDPLYSQEEIWGPGCGKGGVDLVDQVEGESSQMAAIRERVVNMDQRRRTGTTPPPIPDDSARLAGNETAPEHGATVPMRDEGVYANIDIRSPIRLSEQARNVIAGLRRQRDEADDWGKWKEVIWATKKAQDELEAAAGEESEKDKRKRAKIPHPSVNNNLKRSKAVERPILDDTPSPMTPPIEIPDGFCTQCYTPLAPDPDPETLFIYLHALRYETEGLGTWETPLPKWASAEWDGDWRGWVGGTPANAIPMLPEAKARLDAQIAQIEAENAEEARLAAEAEAAEAAGGEKMSVDTPQENGQAVEEDVEMGERIAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMM4</accession>
    <name>K1VMM4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMM4"/>
    <dbReference type="FunCoup" id="K1VMM4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMM4"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMM4"/>
    <dbReference type="OMA" id="IFEDDKW"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="102639" checksum="E2E2EE8EC91FEE02" modified="2012-11-28" version="1">MFSKLPTFKSLPQAIGLPFLSHQEGAMLDFKGGNNGLKRLSGEDVIPISEQEYWSQYWTLFNSATDVYSMLTAQDTMQANPTNVANLVQALATHMFTLLSNPSFPCATVIPPDTVSTNLQVLNCLRVLGRILVIVFEAEGESSLGGQTWADKYLWSQERVKRETPEDLPSEQAQFTIADDDDDEDEDKDKANGKDDEEREKTEGNGEIRDPLSNPGPSAAKTEDDGTELRPSLADRLFSCTIDLLFCAGFTVPESVRGDDLSGEKINYVIWEKGVGSTIAIGSNAELDRNKVEVLRFLLVLVSKTIYTSPTSLQIAANPPLEHLTHDLERRLVLSLLCSLLNTSVAGTKPSAASAVPYNHLMFKAADERRTLIRMCLMNLLVALDYRSFDIVSNNPAIPEKKDENAFRYFLAKLHRKDDLAFVLNGILAILDEHTATMNNYLPGSKKPIPYLLEAYMLLWRLVDLNKRFRSYVFESGKAIDVIGHILLCCLEFKNDPSQHGLLRLLSYLLQTLSADQGFAEALNQPLRQTVPAKWAVQGSAADFMIVSIYSIATTPGLNPLFPALTISIANVAPYLRHLGVQASTRLLQLFKAFSAPNFLLADEGHPRLVYYLLETFNAVLYHQLNENPNLVYAILRSHQDFQTLATFTLVGGLREIQRKKAQRAQALEAEKEKEAAKGSTLKRTDSELAMLAEKAALLGREIEEGDLGESHERVREVDATQADDEFTVVVPKSPKSSPGSVHTPKSPEAAGSNPGSPAPAPAMSEKARGKMRATESVTSLHDEEDEELLKLAAGGVGPNGYVPTQEWVSSWQKGLPLDPVLVAISELLPKFQDSQPATRGGPSSKVFNLLKGASLTDVLPPAPAVVPRRFLWSPQSCIWLSSLLWGDIYVAGLTNPTGVWRDTTVRLFGVKQAPSKRGVQVDRVLKMIGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMT0</accession>
    <name>K1VMT0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMT0"/>
    <dbReference type="HOGENOM" id="CLU_903689_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMT0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="312" mass="35910" checksum="77232C7A8EDD70EB" modified="2012-11-28" version="1">MDAPIEHADPATLWKEAMAFARKEVSAGLRPQWISPSGKESEANAYVVRPPQPPPSTVVAKLRRKLCHRPPFIYTHFRWQENGEWQQISRSDLCAAYLRLCEDYNGLRLALSGLERLARDNDKVTVEKELACRTRFRRELEVIRERGSRYLPRLKWAVGYMASYLTFLCRCEDHNAHPPISSGMWERYSKPITEGGVRLHDKLGHRRLFWSGNMDDYPFRAAMVVNRTETPEGVQVLRKEIERLALEVLRFRDCEYPETNLHQYIPANRKLPSSRLPVATALDTDSKTQSSKSEESGVEAQTESLAPPAYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN06</accession>
    <name>K1VN06_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN06"/>
    <dbReference type="HOGENOM" id="CLU_1797812_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN06"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="152" mass="16795" checksum="0255E0E2EA0D0FAA" modified="2012-11-28" version="1">MPPAPDHEHQSTLKVCGGPRSFRVRLPAASEHDFPDIPGLSKMDQYLIIAQRQRVDDRLRAVEETQRGILERLSRLERSLERSLERSLERSLESNFGEGLSRATNTATNTANGVAEASAAGAENADTQAGSAQTTTESSREHNAQEIRTERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN46</accession>
    <name>K1VN46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000332">
        <property type="protein sequence ID" value="EKD00862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN46"/>
    <dbReference type="HOGENOM" id="CLU_1611970_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN46"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851978" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="18450" checksum="78EFC539B628B890" modified="2012-11-28" version="1">MLALPLLSSLSTISAVAAAPTILRSQLQVYPGGRCLDNPHGELYEGHLVQWWDCAGIDPNRQGLVNPNQGWRPDGQKWRYIADENWCLGFATNGFAVMARCEGYGPDVRSTDWVHAGDIGRLCSQWNIDYCLLDNDDRNGEYAVVWDDLGRQASIQFNEEGFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN88</accession>
    <name>K1VN88_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_04800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN88"/>
    <dbReference type="FunCoup" id="K1VN88">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN88"/>
    <dbReference type="eggNOG" id="KOG4077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099086_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN88"/>
    <dbReference type="OMA" id="CFAYDIV"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD00927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="162" mass="17918" checksum="0895DE135921EB1C" modified="2012-11-28" version="1">MLVNAVRASIRPAVLKASRPAALAAVRFSSSHAKEESYDEFNAKYTTFFEQVGDLFELQRGLNNCFAYDLVPSTSVIEAALRASRKVNDYATAVRILEGVKAKVENKGQYEAYLNDLKPVIEELDGAVHQASQPPPPSETLLDVEWLANTPGVETKEELYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNF0</accession>
    <name>K1VNF0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNF0"/>
    <dbReference type="HOGENOM" id="CLU_692964_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNF0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="367" mass="39398" checksum="AA53532F64B0DA64" modified="2012-11-28" version="1">MRDEDDKQPTTPTSTGPWIDVARYAGTLLNLLHNASSIPDANPTADASAAPDEDGQKACIGCGKILNHCEECESDADTLVVGEYVTAEDLTEQLEGASLNKGDGEEIKSHGEEIKIGDEEVKADGEEVVAERAAGLTSPVIPAVSADPATVAESPSPASSTGVRTPTIDKSPATESPATDKSTDGHEHTPVFPVRIPPTFVIGADSSSPLRNLPEQIRQFLENSSGSSPGPTPGSPAASDSGNPNSSAPAMPGSNTHPNTPSDEPDSPSDAPPAYPLHTQIFDVDRIRLPPTRTRRRTVRAPARIGEIDVEFQSVITRYPHGGWRRERVIRTRSGEEEPQALDVERLREYVAQEKNPWHDYKRGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP83</accession>
    <name>K1VP83_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Preautophagosomal structure membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="4">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000388">
        <property type="protein sequence ID" value="EKC98517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP83"/>
    <dbReference type="STRING" id="1220162.K1VP83"/>
    <dbReference type="eggNOG" id="ENOG502QVZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004046_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP83"/>
    <dbReference type="OMA" id="GLRWYLI"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:vacuolar membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
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        <property type="term" value="P:protein transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:reticulophagy"/>
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        <property type="term" value="P:ribophagy"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="7">
        <location>
            <begin position="895"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="521"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="669"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1107"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1136"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1141"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131437" checksum="5AA5E1B523B71677" modified="2012-11-28" version="1">MDIYLASDGGIVKVEHALSDYDSSTPVTRFKQKHPALTTSLEGVYADVSAATGVVSGNILLFTEDGRELKQEVLEELWERGGGASSSHTEIVYLFNRETFFSEPERWAAELREEVVLPPPLLLSGDIELAQAQSPFASAYDHLCHLQSLFKAQAHALRIAYANLSFHLGPIVEAFREFTGRVDDELDAHDQLLKGYDVDMAMLPKVTVHESLYRRRDKDTDDKSRKSLLDWIHTKKMEQVRDLCQYAHMTRYNNVASEMDELALQSDADLQQAEHRIHGVETEFAEALGRIELAMQQVEALMQADSQLDQAMREDLASMTSIKVSLRAVGIADYQVRITKFSRPMTDLDNDLRQKSAFPHLERLHNLPFAYAANVVEIVRRKEFSHSLVEWASRIGHAVNTYLDEEAKRRQRHKTENQLPWEIPALEESQLPRINMSINGAEALTSVGLGKGDIEQLVASIKELQDDPEFMSLDPTENPIPVLSNRLAELLPSLDHLNEDLNQALDLAVINAAQRETPGETEKLRAQNADYEARIAELEREHLERMQELEESKEQEIKTLNARQAELKDEVARLRNDLSDEAVQKQKLMDQLEEKTRDHEDRMRELEEHSELVSALQADMVQEKDRATDLGVRLQEALLDVDGLRSAETTLIVQMKDMQDERTRILTDLGEAQLLAQNYESELAGAKVELEATAAQLVQAQKDRDKAIKEKSAEAERLMRDQIAEADGDRAVLEHQNLTLTKELEEVRKEMDEKLNSVKNASIRREDGLKAELKLAKAQLRDVQRREALLASELAVAKDSSTQLTQKDAHQAELLKESVQLCGKYHEACYRLMGAISASTTISGSLSLPQRANSPPPPSILSIGSNELKDSAFLVRSLEKASAFELESFADAVLKTINLARRLSKSCKQYRDLSRNKITISSFGKGDLVLFLPTRNAAVNAWAAFNVSAPHHFLHVTDQIRQQLQGKDYYLARITGTDEAIVNGDSPSTNPFGLAEGLRYYSHHVEEWIPTAIRTRRSTSGPAGQTAQASHPPHPERALTAPTAVRAKQPANIISRDRERTSPTSISPKAAAPSPKESSPEATSPHSASPVAASPKQASKSPPPPKDSPKGTPKESPKGSKAGSRRASPERSERREKRSSRPSSRTPTPTTSVNQPPAPVPAASESDPRRASLRPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQA2</accession>
    <name>K1VQA2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VQA2">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQA2"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_3_2_1"/>
    <dbReference type="InParanoid" id="K1VQA2"/>
    <dbReference type="OMA" id="QMLQWIA"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1235"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1453"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1679"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1488"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1523"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1559"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1683"/>
            <end position="1697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1817" mass="202276" checksum="6E68A60EBCE6A4DE" modified="2012-11-28" version="1">MSSAETKAPPGASGQNGNPPAAVPKTHDLGDREFMNDVKKMSDHYNLNPEDGEVFNARTIDHEPTLDPNQVSSAIPGTGFKSQLGHDGDGCEIADEAQPSKYLPHITGPRQAAMPSGVRGGDTQEAPMYQEGAAGRGPGMHEQDVSEVPVDGQGPNDHRFLADGTPRLNPDGTPRPVAFNQPYQKDELGRTTKKMPGVKEEEPPGPRTDISLAPRIVHLQFHREEDPDVPASTATAYGAPLQVTRSGEGEEPAYKDGAHMQGGKYLQSSHSKLQESPENMQPSGGAGGGVAAGASGTGGLREIQTTTIHANIEQPNGQMIHRDYEKTEVLEPQQQRTGAGATGGDPHHPGGQQHGAHHKHESYEDELLDHGLGRVPPPEDQWEDAPDQQWASAYTSPISPLTPRRGSMSNAARARIQNSSGDELGASAAGSRGGQMRNALRFGRKKRQQTTEQTQMRPPNVTNELLTNTLPVMIMKTWIDRDEDGHRAVPVLLGNLRFRIGDSVRVGNKRQNKQLQIASADRPLTDKEKERGGREWFKIECEYGEGVIKWVIYRELRDFVSLHTHYKAANIGTGISGLRSSRRVEMPEFPKQVLPYWARDSAHLYDKAESKVDRSGKGKGPARDSNPQASPRDLLQQYLVDLIRAVMFRPESNRLCVFFELSALTVALAPRGGFQGKAGFIKIPTIHVSRKNNQPGLVPSKWKNHRKPKWFIVRESYFVATDGPSETDVYDVFIIDNDFAIERPKRAYRKGLKALRRHKNSDADDIPTEMREDDEKDASQHTFYISNAQRRLKLVAKNAFIVSMERVAMQTLWAGRNRFDSFAPIRVNVAAQWLVDGRDYFWNLSRAINMAKNRIYIHDWWISPEIYLRRPGDERYRLDNLLKRKAEEGVRIFVIIYNEVMDAATPVNSPYTKKTLTGLHPNVMVQRSPSHLPNGTFYWSHHEKLCVIDETIAFMGGLDLCFGRWDTPQHCLTDEDFTEPSGPNGPVWRGKDYFNERIDEYSDLDKPFEDRFDRSRQPRMPWHDTALQILGQPARDLCRHFCQRWNYLLRTKNHTRKMPFLLPPADFTERELVDLHLNGTCEVQICRSCGPWSMGTNSKIEHSITNAYVKSIQLSEHFVYIENQFFITSTVVDNTRVKNHIGDALVERIIKAHKNGEDWRACIVIPLLPGYSYPVDKPEASSVRLILECQNRTICRGANSIFTRLRKEGINPDDYIQFFSLRTWAKFKSGALTSEMVYIHGKTMIVDDRIVLCGSANINERSQLGDRDSELLAVVRDTDMIDGTMAGKPFKVGRYAHTLRMRLMREHVGVDVDAIEEDELMLRKPLAEPQDVALWDPDNEQENHGGESGVSRLHAKSNALQRLNLTVSTAVRDIAYGVGTNLKLDAERTALKVMHPIKTLEGEAPQLMPFDEDPADRTDVGKDGQPVEGFASSVVPTLEEVTIMRQAANKVKNEMQGNADPGPNGAGRNLNVIVDANGNPIPEPQGQSGHGWADGYGPGAGPSAVAGTGGPAAQAAQEEAQKHQHHSQHLHPHHSNREPTRQDPAGLGQKESTKELHPTASNVSVTSHADSYGRPAGGSISQAGDDTTAVDPSKARNVLRKHLHYKTPAQPETLPVETPMIDPNRFHDPLDPKFWDDMWQATAVSNTEIFRKVFRCIPDDMVTTWDQYKSFANHAGKFLKKRGGGDKGDVKQTHDADGSGGGVVGPAGHDPGKPVTGDTAEQERTGKSAVQGAGGSGKPDERAGPNAVETLVGEEEPHKPSGEDEPWHQWELDEMERLLQKVKGHLVVYPTRFLEAEDMANNFLFNQERILPLLIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQR2</accession>
    <name>K1VQR2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQR2"/>
    <dbReference type="STRING" id="1220162.K1VQR2"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="K1VQR2"/>
    <dbReference type="OMA" id="EYIPGIW"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="505" mass="56448" checksum="84760966AEA5B538" modified="2012-11-28" version="1">MATTQQQVPDSNASSGIDSEKQSIQYVEDRDMKNELEETGYIRTYADIDEGFDPKEVRRIVRKVDLHLIPILAAMYCISLIDRTNLSMARSANGKLMNKELSLDQGNYYSVATMIFFIPYIILEIPSQLGLRKYGVRWWLATAVILWGIVMMCMGFVKTPQQLIATRALLGIFEASLFPGAAFLIACWYPRKSMALRNTAFYFTSTAIGGMSSILAWGISQMNGTANMAGWRWIFIIEGLLTICIGVVAYFFLQDFPDKATFLNEHERNVIITRIQRDRGDATPDPLTLRKALKYTIDPKIWLFSIMFAGTTLASYSMAFFLPTILQGMGFSNMLSQILYAPPKIWGIVPGLLIAWWGDRTHQRAAGVVLNAILVIVGTCMFSQLQNDQKVARYAAVFLSFGSCTANVPLIIAWAQTSIREQSKRGFNSAILIAFGGVGGILSGVLFIESEAKIGYPTGIWSTIGFNAFTAVMAVVFKIWMTIQNRRADRGDVVLEGHPEFRYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQS6</accession>
    <name>K1VQS6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQS6"/>
    <dbReference type="STRING" id="1220162.K1VQS6"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006108_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQS6"/>
    <dbReference type="OMA" id="KSEMHYN"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="292"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="649"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="771" mass="85082" checksum="256A3E92CECC4BD7" modified="2012-11-28" version="1">MRWTGRRNDTDEEQWAGTTVGDPLPCDDTSPPPVQRSAFSAFVHRFLTPRWTASETLTEKTWGEELEDLAEKPRRSIDDYKGEFTWVVVDNDLLLPQQPKSNIESEREIAEMAPPARAASISVGQGAAASAFCMGQRVLKDNVFPFFKSFAYMSFPDKAQERSFQHETSKAGACAGAFFLGLSTVLSIAFTKRWTTWNYYNRALHLFGITAWAVGMAGLFVGQPKADLPMWRNVILATVFHHILVWAAFFRERADRQLFTLRSQLKAQYRAVQAAQEMERRALESKRQFFSYIFHEVRVPLNTARLALANLHAEGAFLELQADQRDLILGLDSSMRLMEKVLNDVLSFNKMEDGRLAFSRAPFSLHSAVNEAALLHRAAAEAAGLEFHIELDERIDALGAIVGDELRVRQVCSNLLSNAFKFTQQGGVRLVTKLLHSDYTHPRAAAGTRMRSQSTGTLTPARPGSDVSIRVEVHDTGAGLSLADMQGNRLFSPYVQTEIGRRQGGKGSGLGLALVTQIVKLAGGRLGVNSEPGHGSTFWFEMSFPLSNDAPTHAPQESLPLTFPGSPTTPCGPGEDPRFPMSVTSRSSYERRESLSAVGEDIPLTGSVRSGRSVRSPTPRGLAAPPLASASIRRAVRHVPRLSSSIGLNTLVVDDDELTRDLMMRTVRRLGHQVILARNGMEALRVLKAAYEDGNPIDIVFLDNQMPAMSGVETARAIRALQWDVYIVGCTGNALQEDQDEYKQAGADAIVTKPVSVAAIREKLDLVRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR79</accession>
    <name>K1VR79_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR79"/>
    <dbReference type="HOGENOM" id="CLU_1023731_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR79"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="33322" checksum="9CA988194803BB27" modified="2012-11-28" version="1">MVTIDHLYYPHIIDALFTYSDPASLAPMAKTCRAWRQRCLDRFYHISDLRILQAPNIRLATLSDLHGTRVSLSSRELALLAGCRVLDITSYHVTMRVWYLHNLQTVRYHQGLVDYPPLRAGQLVFKNELPPFRYRNTVAERLVIYFTGRIEQLAWYNRVLPYVRQLVFIFEDNDYDEEDCPSTESNNDGQDDSNLDHSMPALRAIKSIIEEALNQPTAVVLVGTERWSLETFDALQLDIDRVYEHYDEHLHILRPLTLSTLGTYRKFVGEREWSVITDWTKMLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSA0</accession>
    <name>K1VSA0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000283">
        <property type="protein sequence ID" value="EKD02432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242857_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSA0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1595"/>
            <end position="1626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1640" mass="176777" checksum="9DFF6B730C386401" modified="2012-11-28" version="1">MSREPPDSKRNRIARNLFGPRPYHTRVQTSQGGGNSISSSNQGPQAGPSTASLGTQPATSNHAPSTAYSFPPTTDYSVPPVTNYTAPRATGYSAPPATVYSTPPATNSTSQALAFHQFPNTVAQSNSEAIRTQHTSQVSALQQFAPQQLSQSEIEEALQFPLGNLPPPLTWGQQGYMSPALAGYTGVYGNEVESGNHDRQVIAPPAAGNTGTSSFNEPTVRHGGSQDFGANINTATVPGSSTYDVLAGASVSQYYRTLPPAQQVPANPTQPQTMQQPYGGISTAAPPTIPPSQHTVSSNHTTASQNSRGLNDRTNRLLGQNSRSTVDNASQSATFPPWLLAPDLGPRDVTTGEFEQFRRNVAGAPMERPAHRGLLNSFPMVRSNEAPSASFNTHLVQTQGPSNPMVPPPSASAPLSGPLDEVTTSNTQQFQAVDPSSTPLGGTAGSQDECPLSMAVLLAGALQTQNQQVLHPSQTSQAPQPQWQSQIPAEHGSRNLPTESSQSHPMNQVRQSQPLSLGYNHAAHPSAPAQPWTLHPGYGQPVPEAGVSGPSTSAATTDTTMAFLGQAATDTSMTDDHNDTTMSPGQEYENNETSDSTLTDFELVPSPEPEPEPARTPTPPPRVDEAQFAADLRNGTVNPARLRGGFALPGFQPPPGGTERLNRLRRTFQGQLMKSAANGQTGQGSSTQGSSTLGPSTQGSSTMGSTINGAQVNADYANSTLQEWANRLQVGRIQEENAALGAALVAQAEGNSSTGGSWTWAVQSEAPYLTLKTFQPNKNAPRSSTGGKTPRTAEPRTSVMGTSAAASRTQDNGDNGTSSASGASESSTATSSEVVTPPEPDTNNNPPSPGSSVDAEGSTDEECEAGHIGHNFRSFRAEIVNSATPFPSASALKQGQKSERKREHKQIEMTYEDFLDLAKAVKDSNLPTMTTNSELGTTRDKRLRTALGVTEPMVHVEWLFAGGVCGIRVVQPPSRAARPDRPTLRVNADRRPRHMSERAYEMATAAYVETSPQLQLVELALDRVRQQGETILGLHETTFRPRALRPKRRPQLAQMPADKWPAPQVPAQQPQQRETQRRRQPSSSLDEQAQRVLEAIIQDRNLGRVQEPGSGSSSNIADRLQNLNLGQASREGYMPWHQGLARLPVPRPRGSTHQQAESLPAGLQRLLNDLFPPSPTAAYPTPPPAYQNEDTPSGSLHNQHNQLAAHLHRQSPPGYHAGLHMPIRAPNPVRPPMMRFRPPTQAQLGPYRPPAGYYGWANAGPLPGVPGAPAEWRPLPTPSVNRRPPPPAFGPQYQARPQPTVGQRPHIPGQNYRPQRPSASARPAATPPAYATAPTTLHHPRPLHHLRPSLHLNIAPSSPLVLPRPSPNTQRNNRLHEAAHRAFNNPPTRPGPGEGHAFINGAIILNRIVPDQVPGADVFPYGPRAENVAEPVRVLQLDGDQGTFEPNGLRVDERVIKLREAVEKEYRRFRRWLRIVTRLARSPRVSERVMWRLRVYLARVARLRRAEHDKADKPAKNDHSKPDNLDSAAPNGDSTQKPQDLSRPTPDRKDKPKQTTKFKDGFRNRQALKGKKSQKQQAAKAMPTGSKAAESESTAEEKEKQSNEKQGGEQKAKLDDDSHGDEKEGGEGGDEPQPSGCTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT31</accession>
    <name>K1VT31_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endoplasmic reticulum Ca-transporting P-type ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_05802</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT31"/>
    <dbReference type="FunCoup" id="K1VT31">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT31"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="InParanoid" id="K1VT31"/>
    <dbReference type="OMA" id="QKTKYVW"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1093"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1160"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="15">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="270"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1197"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC99837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1233" mass="138185" checksum="6024CCE9272FC870" modified="2012-11-28" version="1">MSSSRPAIKSPEIESVSLLNPIPISWRIYGLPWLSLWPALFYAYNFAYDKYIGSEEWTFIYCVIVFGGHLLSFLATRWSNNVRAVLCYRPASSLDTASTVRVIPKKGKGKGEFVPLDKQPTPGAETSTRYSFIYQRDTYVFNQDVKEFERIPYPCDSNPPLSVFQNSRGIVTHGTSTKAPSYDYLKAMYGPNECHIPIPKFTELFAEHAVAPFFVFQMFCVALWCLDEYWYYSLFTAFMLVVFECTVVFQRVRTLTEFRTMSITPFPLMVFRDGKWKEVISSDLVPGDMVSITRTKPDSGIPCDLLLLRGTCIVNEAMLSGESTPLLKESVELRDPADRLDINGSDRNEVLFSGTKALQVSPGDDGGIKTPDGGCLAVVLRTGFGTTQGQLVRTMIFSTERVSANNFESFLFILFLLIFAIAASWYVWTRGLERGMAKGKLLLDCVLIITSVVPPELPMELSLAVNTSLVTLQKFAIFCTEPFRIPFAGNVDVCCFDKTGTITGENLVVEGVCGVDPKDPERLEDVKVVGKETTLALAGAHSLVLLDDGTIVGDPMERTTLDALNWKLSKGDNVSPNETNATHDYQLTIRRRFQFSSALKRMSTIASVTDKSGRKWIATVKGAPETLKSMYTNVPDFYEETYRYYTRRGSRVLALGVKQMALTPDKINSVTRDEVESNLEFAGFLVFHCPLKPDAVETLKMLADSSHRCIMITGDNPLTAIHVAREVEIVDRDCMILDLKEGSSDQLVWRNVDETKIIPVNPEEPLDQDILRDYDICITGPTVRAFEHRPEQWKDLVTHTWVYARVSPSQKEFIVGTLRELGYTTLMAGDGTNDVGALKQAHVGVALLDGTEDDLKAIAEHQRNERLKKVYEQQCKISARFNQPPPPVPPQLRELYPELVQTQQEVASTHQSAKKQNPMEKFDLTTITSKLADLDDGQEVPQIKLGDASCAAPFTSKLANVKAISNVIRQGRCTLVATIQMYKILALNCLITAWSLSVQYLDGIKFGDYQVTITGMLMSVCFLCISRAKPVEKLSRERPLGNIFNLYVLLSVLLQFGVHIVALVYITGLCKSIEDRGIIDLEKKFEPTLLNTAIYLLGLSQQVSTFVLNFQGRPFREGIKENKPLYYGLAGASLVAYSGALDLFPDLNSWLQLVPMAWSFRWRLAGAMVADFALCFLVERACKALFANLEPAELVTRGRERREARRAIEEKEAAQKQLPEIEEVVTIEEKKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTE8</accession>
    <name>K1VTE8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Positive transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02796</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTE8"/>
    <dbReference type="FunCoup" id="K1VTE8">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTE8"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_1_0_1"/>
    <dbReference type="InParanoid" id="K1VTE8"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="163"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="34559" checksum="C5EAFC44FC0B83D3" modified="2012-11-28" version="1">MPMDATALTASVKELNEASAGGKTEVSFIDVGLADEQDIIRLLKKLKADVEPTEELLRTSRAGIAVGKLRQNATPGVSSLAKEIVKQWKEAVEESKRKRKREAEADGSAPKDDAVKRVKATSAAPSSGAASPAASTPAGSAGDPRSPKSPAPLTTIDSTRTTPRNSKTDDMVSRLRNKKTIAERAIGIEREAFKLLKFNSGNEYRAKMRSLFLNIKDKGNPGLRNEIVLGQVTPDKVVRMSKEEMASESVRLLNEKLAEKNLFKAKAVGVTQAETDAFKCSRCQQRKCTYYQMQTRSADEPMTVHGELPNQKKRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU80</accession>
    <name>K1VU80_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU80"/>
    <dbReference type="STRING" id="1220162.K1VU80"/>
    <dbReference type="eggNOG" id="ENOG502R80G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_2_1"/>
    <dbReference type="InParanoid" id="K1VU80"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="156"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="293" mass="32633" checksum="60953495C140FA58" modified="2012-11-28" version="1">MAPLKTLVFGATGAQGGSVCKYLLEQPDKFKVYGLTRHTDSAHAKQLASQGVNVLQGDLDDPKSYEDALKQVDAVFLNTNWWQWYKPDGKGGDNADECTKRETTQAIAVADAMQRIGGKRLVYSTLGHFEINGQKVAHSESKVIKDWPVDRLRLENADGSITIECPMPDSAEIPQVPIEQLGLWVRAALSDWDKYDGQTIPCVTDKLSVKGVTEVLSEVTGRKFVPMHVTEQWFKSKEAADPNPEMHLNSYVFVEDLVKPEIKESRAIAPDAWDFRGWCLNAGGVEKKWGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU86</accession>
    <name>K1VU86_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU86"/>
    <dbReference type="HOGENOM" id="CLU_1310886_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU86"/>
    <dbReference type="OMA" id="PNTNDTF"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852419" evidence="2">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="210" mass="18365" checksum="A4055B0F8DAABDEB" modified="2012-11-28" version="1">MRFATLALLLAGLVAAQNAAQSATSAAESAVASATGGNTGEQSSAGGGDQGQQTSSAGGDGADASQTSSAGGDGADASQTSSAGGDGADASQTSSAPAGEQTSQGGDASQTSGGDAQPTSSAGGADSSQTGAGGAGGDSSATPSGQSGMSSQSGASQSGGNAASSMSSAALGSQSSGASAAPSGGSGSGASSGTPIAGAAVAAAIIAAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUF5</accession>
    <name>K1VUF5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUF5"/>
    <dbReference type="HOGENOM" id="CLU_444950_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUF5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="614" mass="64975" checksum="29EFEDB09AFDD7C5" modified="2012-11-28" version="1">MKGEDPNKLFIPPVPDSPEKRVLPQSPASDRTASPVRVPPPMTAPPAPPPTMPHSSFGRPSRKQPEKVRTRKEAVGWDTSSEDEDDVKKSSPVIAAPRPLKSAMKHPSRTDLMSTSPAPAPAPSADDSEPDEPLRQVRARASSRQELRSVSRQQEQRPPSRGDMRPTVSRPGSRQDLRVDTGVTKQPVPHGPSAGQPRPNGGRSVSSSHVSASSHTTATPRNAGLTKSSSKWSLSDSSPTGSEQPSRPPSRPGSRARMHRVASSDRLRAMPGGVRSSHHQTSPPTGGPLAALNHDARHSASPASSQSALTGDSSMQQPSTPRSNTDNRRSWGADARLRVSSDANEARVRPPSQFDWMNAANGAVPQFPGMDPAYAAQAQAYVSKSKCVADVNSAMMNKQQFYQQWMAAAQAHFDDAWERASNVSNAQTLPGNNPMMGQMPMGYSYGAFPAGMASMPVPPSAMFNMYGGYGYGMPAMPFPQAGMSSGMSSASGMTGMGGMGMGGGMYSYAPPAQSVFGGEFGPPVQAPFATEPVAGHGGSGGSPNRRSRHLDGGSVRPQSVASGDIATPPRRQQRRASGMALSEAGGPVSAWRGSRYELNEQTPRARRSSHANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV50</accession>
    <name>K1VV50_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-finger protein zpr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV50"/>
    <dbReference type="FunCoup" id="K1VV50">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VV50"/>
    <dbReference type="eggNOG" id="KOG2703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024138_1_0_1"/>
    <dbReference type="InParanoid" id="K1VV50"/>
    <dbReference type="OMA" id="KCTFDQN"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="7">
        <location>
            <begin position="121"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="7">
        <location>
            <begin position="380"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="511" mass="55488" checksum="3C521F06F207B41F" modified="2012-11-28" version="1">MGSLKTGPAASSSGPGSAPASSETGCLSEMPDVARLSSEGRNVGMVSHNEARNCTSETAMFWESIVVSLSWFVLGDKRTPDDSIQPAKENLFPSLGDVASRTDAADADVPEGSRDMQEVESMCMRCHENGKTRLLLTTIPYFKEIIVSSFFCEHCGHRDTEIQSAGEIQPKGAIYTVHLLTRDDLQRQVVKSNWATVTVPDLQLTIPPGRGQLTTVEGLLRDTVRDLSIEQPVRRIMDPPTAKKIDDLLAPIRDILDISESDEDGGVGRDDPSVQTESEGQGRPFKPFTLTLDDPSGNSFVAFKDTTNDPQWNLRAYNRTLDQNVALGLVAPEDGEKAKAADAVPDDHKKMTAEEAMGTIKALEHSDGSVAPDEVFTFPSTCSSCGHTLETRMQQLRIPYFDDVIIMSATCPTCGYKDNEVKSGGRIKPLGKRITLKVEKGDEDALSRDLLKSDTCGLEIPEIDLKLQPGTLGGRFTTLEGILNEIYDELSTKVFKTGDSATAGIGQETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVI9</accession>
    <name>K1VVI9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVI9"/>
    <dbReference type="FunCoup" id="K1VVI9">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVI9"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_4_0_1"/>
    <dbReference type="InParanoid" id="K1VVI9"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="582"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="636" mass="69399" checksum="3B54330D8FD6D66D" modified="2012-11-28" version="1">MSENNIPYTLPLPGGIPDTHRPHTERTTTILVPKENTAFLNPVQEYNRDLSVATIRAWNNLRKEELEGRWRQKLEREAKKKAAKKGGEAPVDCAEPAAEIAESAEAKAENGAEGEAGPSTEVCPAPRLLRIADKTQRKFRAPKFTILEALSATGLRSIRYAKEIPDVRTVLANDISPSACDAMRRNVALNGVGEPSQPTPSEAAPTGVTDEEMAENAPDLGRREGCTGHVKVNEGDACALMYSRRGLRDRVEVVDLDPYGTAAPFIDAAINALGDGGLLAVTCTDLAVLAGSNYPEKCFSNYGGTVVNAEYSHEVALRLVLNSIAQAAARYGKYIHPLISLSIDFYVRLFIRVDTRPAEVKRLASQTGVVYACGFCQTPVLQPFGREVQKESKKGNATTQYRVATGPTAAGKCEECGSTQALGGPMWLGPIQDREFIARLIGEIEADKEHYGTYPRMHGMLTLAGEELDAPFYFSANKVHGFAHSSAMPTKNYISALLNAGYKVSRSHALSGSVKTDAPRSFVYDIIREHVKEHPVRLDKISEMSPTHKLLAKPMSHTVDFAPHPDAKKFEKDKDSKAVFYQVNPLPNWGPGSRAKSVKAAKEEGDKGEKRKSEDAPEGEAKRAKVDEDEEAAMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVS8</accession>
    <name>K1VVS8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000217">
        <property type="protein sequence ID" value="EKD04641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVS8"/>
    <dbReference type="STRING" id="1220162.K1VVS8"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_0_1"/>
    <dbReference type="InParanoid" id="K1VVS8"/>
    <dbReference type="OMA" id="NDLLCGC"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="342"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="856" mass="94036" checksum="9F6D6067F9E3B28E" modified="2012-11-28" version="1">MAPKPHHRETRKWWWRPQAGQQPNAKTRSKLTSSNVARLPSSIPGSPAPGSPGLPPASAQQRKPTAASNLSFADSPPHSDGGSRSDRPPPRRQGTSNTSGSGSSPHASPTATRHPKQHSGPLHDLRRFLNHHIGHSDQKDKDRYQNSIAQQALHQHLDESSTNSTGTPSLSGAATPGNQVRGSQFFGAGGAASSGNSTPTSQLPDGVGKDRDKDHHGHHSSHLVGFMKHHHRDKDGEKSHSSLASFFGGGSKKKDKERQQRAAHAGVEDHGSRPSSRPGSAAPSRTSTLMMSEHHHHDSHHASGHATPKNLNDYPGVPGPVIALTHPSSIEATHAHLSKKYGKWGRVLGSGAGGTVRLIKASQKTGGSTYAVKEFRPRRQGETEKEYLRKVTAEFCVGVTLHHINVIETVDIVCDHGHYYEYAPYDLFSVVMSGKMNRPEIYCVFRQIIDGVNYLHSMGLAHRDLKLDNCVMTSDNIVKLIDFGTATVFHYPGKHQIPASGVVGSDPYLAPEVLTRDTYDPRLTDVWSVAIIFMCMILRRFPWKIPDYKTDMSFKLYVNTHPDLCQKPQTKTPAPSVMNGTDAHNRQGGRDTLLPDGSSKLPFKRTPSNSTQSTAVDSRVSEVSSTTSHGSTDTFTPRVDRLKLTESPQKDRSDQYFPRRHDSTASLPPNTNPQYARQPRQQTLPQPVSPTRAAQPMPRNRASSTSGAQPTVPLSKEQTQQRAQQQQKRRERAASISSTRTYQTGGAESIFRLLPRESRSAIMRMLAVEPSIRCTLSDLLHGTGKDDQMCPCGRGECGGNLARPPEELTGVDVNDDHGDAWIQNIECCSHHPGRKMNHTHIKVVQETEKPKKKLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW49</accession>
    <name>K1VW49_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000243">
        <property type="protein sequence ID" value="EKD03637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW49"/>
    <dbReference type="FunCoup" id="K1VW49">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VW49"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="InParanoid" id="K1VW49"/>
    <dbReference type="OMA" id="WQLMRKN"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="183"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="323"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="444"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="565"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="675" mass="74727" checksum="FA0BA30F98592AF9" modified="2012-11-28" version="1">MCTRKTTHHPADGGVRSNSSSPTVYSAVPVFDPLSYILDPSGFRSLFPSSCDRLSEGRTGPADPSTEMSHAIRLGKKYPDFSQDEIFQLINRFQQIDVDDKGSLDKSEAIAAVQQSGDADYDTARETMKSVNIDASGRLEVEDWVQLHSLLRQNKQHPVLEAHKGRIAVKGTGGTSTQHTVNEDELRSFTDHINGVLGGDPDIGDRLPIPTDTMQLFDECRDGLILSKLINDSVPETIDERVLNKPGPKKKQLNAFQMTENNNIVISSAKGIGCSVVNIGSSDIQEGREHLILGLIWQIIRRGLLSKIDIKIHPELYRLLLEDETLDEFLRLPPDQILLRCVNNFSTDVKDGENYTVLLNQLKPDVCSRAPLQTQDLKQRAEQVLENADKIGCRRFLTPNSLVAGNPKLNLAFVANLFNTWPGLDPLEEAEAPPEIEDFDAEGEREARVFTLWLNSLDVDPGVYNLFEDLKDGYVLLQGFDKVIPGSVIWRRVSKPKEGQELSRFKAVENTNYAVDLGKQNGMHLVGIQGSDIVDGTRTLVLGLVWQLMRISITQTLASIKGGKPPTDQDMVRWANDTVKKGGKTSTMRSFKDPSLSNGVFFLDLLNGVKPGIVDYSLVESGNDPESHRMNAKLAISIARKLGALIFLVPEDIVDVRPRLLLTFVGALWAASSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW94</accession>
    <name>K1VW94_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW94"/>
    <dbReference type="HOGENOM" id="CLU_991068_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW94"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="281" mass="32122" checksum="A59573ED14B877AB" modified="2012-11-28" version="1">MKNAINNILSPEHNITLHELRFTINNTMARPQARTLPATPLEVAQPATIYLRMKRDENEYHIVAITDNYDDAHSNLDLRFFSGDDTLHGVLSDFACMYGTHIYTPRYAMRAFSDTEEAEPGWRPLPHNMRLDAVMEGFELRLLQIRFTIKSLALLCWWGQTVQRMSKPEISDQPSPPSPAELRDTCVEYLFDFELFESRIVVASVCRGQPPYSHPEHIATQTDRTVDDVLSALCKLARIPYAEPKDAPLLMDQNGKVILPTQRLDEWLGNTEGALLYAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWT4</accession>
    <name>K1VWT4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWT4"/>
    <dbReference type="HOGENOM" id="CLU_769843_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWT4"/>
    <dbReference type="OrthoDB" id="10660959at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="360" mass="39859" checksum="7B22FAF41D2B546A" modified="2012-11-28" version="1">MYYAINSWSNVLIFPASQAPHYKHGWPVIRPRNHRQVQLAMEDEGVFVDSTHKLDEEEDALRKYGGESGTQAAEEAGVPVLNSRSGKLARIQMRSWIWDMVKHSVTSLARMGTPREIAYLGPVTHLRSSTSAYRQSPSPPPMAEGLVAALYLLSGRLRAINIGNMITARTAALGAAAASAIPLIDVIRLKKTYPLRDGPADAPWPKIVGHPNEVATHVRIPRDVNAREAFVNAFYQNWTLRFLGDLCQRFHLEPAPLPGYTSQGTATLPASYGHGMWPVLARTPDSTMVWWQADKPGKGGAQLLSAKRGQGDDVEIAFGGAETPDLTVDAVGRAIERVHFVYMQYLIDRAKRRLAKEYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWU1</accession>
    <name>K1VWU1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWU1"/>
    <dbReference type="MEROPS" id="S28.004"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023630_0_1_1"/>
    <dbReference type="InParanoid" id="K1VWU1"/>
    <dbReference type="OMA" id="GAATNIH"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852522" description="Peptidase S28" evidence="7">
        <location>
            <begin position="20"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="66473" checksum="41059C9F6AE95093" modified="2012-11-28" version="1">MLLTNLVALLPLLAAPALGQEEDEFGMDFTRNLEQRLQNVGVFKKPLNKQMRVGSPWGPHCFTQKRSHFDGSTETFCQQYLVNKEHYKPGGPVFILDNGESEVLSTTTMDKGSLASLLARETNGIYVKLEHRYYGGSNVTEDLSTDNLRWLNVRESLEDSAEFIRNFPVPDGLELPEPDLLTPAKTPFIYIGGSYPGGKANWMRKHYPDIVWGSIGSSAVVHAEVDFWQYFDTVVKHGEPECVSAITESIAAVDKLLDDPKTNAAIKAVFGYTGEISNWSFGNMMSGFYGWQVRSWKADTDSWRRFCANVTAGAAQGQLTVDSLEAPIPGAVKAWGDLSKQSILDRLAAGKTVDNIIQALDRPDPNNVGLDQKWRLWEFQTCTEWGYNFASPHDPNAPRAISKFVTANEYRKNNCYADYLPGEHFQLPDIADVSKVNSLGDYSIAADRMATVDGEWDPWRTMSVGAEGQPIREDTIARPHRLIPKGAHCWDFSTLDDITKEPKDIREVHEWELNFVKAWIQQFYDEKNGNGNSTTGGDGHGNGNGHGNGNGHGNGNGNGNGNGHGNGNGNGHGNGNGNGKGNGKGNNGNGNGNGNGNGKRRLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX88</accession>
    <name>K1VX88_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX88"/>
    <dbReference type="eggNOG" id="KOG1313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051554_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX88"/>
    <dbReference type="OMA" id="FFANCLT"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF301">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="435" mass="48723" checksum="EF5123CEA7D77C69" modified="2012-11-28" version="1">MGLTPTPMTLAGALLPPALVTYFLWAHRRLLGVISPLVWAQSPVLGTLYAIAIRLIIVITVLFLRLYLLPRKQSVPPPETPVEHALGELAREPDGPVRVSTLSSLGLDAAQLRRLAGERARVLGRYLDEDSGDLGGVNQDVLVLPEWCGRCSRTRPARTRHCRECGVCRMGFDHHCAFFGNCLTAPYLPCFLALLFLTPLVVVLLSLPTYAPLYARGKVAWTLAPEWWWGAWWSWIFGGPLGRWIGGIALGWRELDNLDPSEESSVEIAALIFIGQILGLMTLALGYTTASALSRGQFTVDLARAKSFARDPERFAQITRFYIPLLPVTPLSSPPLSTASPVSPLGSGSPVKEPDNGFYDVPGYTSYGNEVAGVLVTLREMNLYDTPATWRWVLRGKARFWRVLRSEWRDEELMHWPIRRDVLRDVQRQKERWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYU5</accession>
    <name>K1VYU5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYU5"/>
    <dbReference type="HOGENOM" id="CLU_2160187_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYU5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="12537" checksum="BB653C76A2A2F13A" modified="2012-11-28" version="1">MSTPPSYDADVFSSPPDPPRGSWAAREKRRRENGGVDHIISSLGTPLDLPALPPKPKKPRQRKVRSKEEVAERKRAEEESFQRVKDVFERLIKGAEKRGYTFRVGDAAVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0Z0</accession>
    <name>K1W0Z0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0Z0"/>
    <dbReference type="STRING" id="1220162.K1W0Z0"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281996_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0Z0"/>
    <dbReference type="OMA" id="AMIMFMK"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="670"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1075" mass="114413" checksum="FB2AC7207AE98BC5" modified="2012-11-28" version="1">MPGQEPGAPTAVAAAHHQQPPPPTQDHQFQDTTTAHQQQPQQPPPPQPQQHQQHQQQQPTYPSLAYPAGPSQHQPPYPPNNYPYNPYYAAQQFPHHHGQQRPHHPNPGAGAFQPAFRYDNYPGYYQPQFYPPYGQMPVPGPGPGTMQNGYYVGGGANFQRPYGGFEGDQKFGHEDDGSGAYHGNPQFAPQQPFYPPGHPYAYGVGVGYQQPGMYNGMGYRPDGVYMGGDQQQQQQPPPHGGPNGTSAPPVSAASSKGLNPAAQGFNYPVRKNEPTSRTAASANANGPANANGPLPNGHASAPTVLEQPPPAQVPEKAKDAGSLGLSLEPPPSVSEPAATDSPSPAPAPASAAPAKVDQPAQPDTVPSTHPSSDNANDSASSAPSASHPPPPPALAEPSPVEPAGLTFTGATLAGFTSPPPSSCTMPRKKQLAADPVRLRPHRPAHDTEGGNSYAAHLSRFVPASVKSESVAADSESAPRRKSKGSSKPRGKAVYAVGVKGGRQPPPHRALTFGDVITEPLSREPEASKAAGVATPTPAAPTAEPSASTPAPAPVRSPAPASVKPSSWASLLRSSQPAKSAAGTPNSLSVAASSTLPSPSKSIDSLPAESVASRVPPSDGRSTPRSPPAAKPSSWAAAVGAPPTPAEDLARLLTDGLTGRPAGAPAPIVPRGLINTGNMCFANTVGYFCLSCANPPQILQVLRYCTPFTELFEELGKRLKADLARRTPLLEAMVVFLREFAPGPSTNGSNGTSTPKGKARDNAFIPENVYDAMKENKRFDTMRRGYQEDAEEYLGFFLNTLHEELLDLYSRTAPAKPVAKSAAANGDSERTIDRPVSPKGRRNDDDDWLEVGKKQKTHVVRTAETRESSVSRIFGGSLRSVLHTPGSKDSVTLEPYQPLQLDIQANEVHTLVDALRHLNEPETVPGVWSAARNANVDATKQVYLETLPPVLILHLKRFVYDPQEQNVVKRSKPVAYSTELTIPAEIISPAKRTPQGIKYRLFGVVYHHGHSATGGHYTVCVARPDGTGWLHFDDETVQPVPTEDVIVSEEEERDGRAGTVAGREKCAYLLFYQRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2I1</accession>
    <name>K1W2I1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2I1"/>
    <dbReference type="STRING" id="1220162.K1W2I1"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283732_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2I1"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="554"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="673"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126519" checksum="A2C9D24C3E880DFC" modified="2012-11-28" version="1">MKYGKEFQSILESSSFPDDWKHSAIEYRKLKKLIKDVVLELEGMGLSPEVLNRLLVTDARSPGNSEGNTPEPLSRSDGEKEPEFEFEFEDPGVLGANGEPELRVEELESEHRYRVRLRGREDSPARLAGSATSPAPISVSDLMMQRTPSATSSVEHRPRVRRGVKAEYILDELESESDDILLESPATTLSELDTEDESDDIDEPPVIPPSPQLRKIRSVPSPIWAMAAGPERGMRELSLGEAHDEDATPTMAARHYPAPPTAGLSELGAPTLNSIREMPSPPQGYAELPTTPAAFTGGATITEIPSRPGSVASEAGIRGVASSPGSEYIIPLEADVRFFEVLTAALQSLTEFHKDQQELFSASVRQLCALVSASIQPSGDVIDLPTPPNSMSDPTPYVYHSTHPSQKDLYAWRQIFSLWVEAEIFESNAERDRGERSVDEAQKRLTSFANAVVKRGLGDRRTLRGKKTRKAWDEFLRLNVLLLDLKRFQTANIEAARKILKKHDKRTALSAGSLVPLARGSGWTFYSTSLPHVLLASLTETLLPILPSLDDYACLICMSIAFKPIRLSCGHLFCVRCLVKMQQRGSNNCPLCRKETVLIADKTNLDSHLMNFMKDWFPREVREKQSENAKEIAKENLEDAGIDPRLVTDIHVSGSAKDAKDDQDKCLALLIARPHHPRQRQRPYHNDQHEQTSTDDMVSTFPPHLGPSVAPSPQGPPTVLLPLSRPPPSTAPPHPDRPSLPASFNPPARWERTLHAAPATYPKQSRVSYGAHSRSSAPYGPEPTSKEPVEVRRKRFADEAKVIVKGNLEAEATQWKPEEIGQAQKVAGAGQWLSIERWRRLEPVEGGVTLVCAHANGLNKEHLLTSSRPGVFGTDTPLPSSLQVNDVWLVDDTHHGVSVSLNADRLNEKVTWDDGARNLLNLIKHVIPAYPSTAGWQLDWHESPGRVPVIGVGHSIGGNNVVLAALTEPELFTGAFLVEPMCTPKAWEHRQAMALTTLKRKDTWASLEAAAEMRNSPLCKDWTDAVFDLWLRTSLVPRPSGGVQLATPRWCEATCFASPSAPQRAWDALEQLKIPVGFVMAADTRWMGGEKAAHEMCHRPRRSRHEVAHAGHLIVQEKPEELGEAMGRFIATLGAGVWDQTDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2V6</accession>
    <name>K1W2V6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2V6"/>
    <dbReference type="STRING" id="1220162.K1W2V6"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="K1W2V6"/>
    <dbReference type="OMA" id="QRRKYMG"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="452" mass="50020" checksum="DFC4FBFE72E0067B" modified="2012-11-28" version="1">MDVRATSTPNEKTSTTEYDDTKAVGSIDEAAEAELIEIDPADEKRVVRKIDFRVVPMAVILYLVSFLDRANIATALLKTLRPSRLIPTIVLVWGGISIGNGFAQNYATVLACRLLLGMCEAAFSPCLILYMTMFYSRYELSLRITLLYSMIAGSGTIGGLLATGLLKMDGLRGLEGWRWLYIIEGAVTILVGITYFFLIADSPETARYLNDDDKAVVRLRAKKEAVFTHDDGFSWVEVRKALTDPVIYLSGLAHLGFDTCMYGFSTFLVVIVSGFGITAPVYFWCTLCYFIGTFIVMRYHSIYFVIMGFGLVTIVGYCMLVAGVKGHAAQLVGCILAGSGIYLGVGLHVTWLAQNIAGFRKRSVSVGMQQTMGNIGGVIAGQIYRDSDKPAYIIGHGASLGFWMMALIGITVEWYVWRTRNKRRDMMTAEEKESIDAKGITGDHHYSFRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W363</accession>
    <name>K1W363_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W363"/>
    <dbReference type="STRING" id="1220162.K1W363"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="K1W363"/>
    <dbReference type="OMA" id="RDCAIAK"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="36178" checksum="EC3F6EB52CA968E1" modified="2012-11-28" version="1">MTGTMKQWYIEKRDGKLDSLKLREVPKPKPGPGQALSLNYRDHVILHDAYGFPIKDDVVPISDGAGEIVAVGEGVTKWQAGDRVMAIFSQGHQDGFVTDEDGTTSLGGAIDGMAQQFIALDQTGVVRIPEKYSFAQAASLPCAAVTAWNSLYGLEGRQLLTGQTVVTQGTGGVSLFGVQFAKAAGARVIATTSSSEKEAMLKKMGADHVVNYKTTPQWGAEVKKLVPGGAHHIIEVGGPGTLEQSLASVRREGVISMIGFVAGEGKTPDLLQTLLKTCIVRGIWIGSRKQAEQVVDAINVNGIEPTIDQTTFKFEDLPKAYDHLANARHVGKIIVNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3T2</accession>
    <name>K1W3T2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Amine oxidase</fullName>
            <ecNumber evidence="13">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_02141</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="12">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12 13">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="13"/>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3T2"/>
    <dbReference type="FunCoup" id="K1W3T2">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W3T2"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_2_1"/>
    <dbReference type="InParanoid" id="K1W3T2"/>
    <dbReference type="OMA" id="QDGNIEC"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000006">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="16">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="17">
        <location>
            <begin position="131"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="15">
        <location>
            <begin position="278"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="11">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="12">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD03558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="731" mass="81777" checksum="89939710103B434E" modified="2012-11-28" version="1">MVTDVNANLAHPLDPLTAQEIKLAADTVRAFMAKGKFEGAPATPLFNSISLLEPPKYDILRWAKTFTPKELAAVGAQLKPITRQADIHIICNQSNQAFEAIVDLPSNLKGEDACPEPKVSSWKLLEKDIHPSLQTEELLWAEEICRTDPKVKEACEAVGLKQTDIYVDGWCIAVDERFPGRRLQQCFVFARSRPGDNLYAHPCDFIPVLDSNSGEILTIDYPHSHSTTDKHSPSGSDAYARAEPRERFAPPKTNHNYLPEQIMQDEPNFKLREGLKPLHVIQPEGVSYSLAGRMMSWQNWNFHIGFNYREGLVISNVTYDDGAKGNRPMFYRMSIAEMVVPYASTIYPHHRKHAFDTGEYGVGALANSLALGCDCLGSISYMDAEFVTRNGGIQTIKNAICIHEEDAGLLHKHTDFRDNVAHSARNRKLVVSMICTVANYEYGFYFNFALDGSIELEVKATGMVNAYPLAPGEKANTKIEVEVAPRIAAQHHQHLFSYRIDPMIDGLQNRVVQVDAVQDEAPVGSEENFYGNGFHTEKKVYKTSKEACSDYEAKSSRVWSIENPNKLHYATGNPIGYKIKCKDMPPLLAKPGSMVWNRAPWARHNMFVTKFHDDELFPSDVHINQNPGAEKFGLQNWVDRNDNVDNEDIVCWPMFGVTHISRPEDWPIMPVEILRCHVVPNGFFDRHPGLDIPSKKDMKSRNANEAFVGNAPYANGNGVATNGGGCCSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3V6</accession>
    <name>K1W3V6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3V6"/>
    <dbReference type="HOGENOM" id="CLU_090757_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3V6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="210" mass="22131" checksum="294886D4E949DE45" modified="2012-11-28" version="1">MGASSYNVMIVHELTADYPYPTNTSYPVPPLPPIPVPLGVKRYRPQPSKTILPDLSPPIPPSSPLYGIEDADEAVAAHNKAYPQFVARYEFKGSTLLVRIGGGGWIRVFLSGSDVLGVRFLPSRSTSVLSAAKPEPKLTSGASCSCSSALGPLGADYGAVQLSAHEHSPDSLPHPGAVQAALRAVSLLPPPPERDRRIPAGTHRLVAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4R3</accession>
    <name>K1W4R3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4R3"/>
    <dbReference type="STRING" id="1220162.K1W4R3"/>
    <dbReference type="eggNOG" id="ENOG502S1UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_886193_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4R3"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="314" mass="34394" checksum="5D9D4BAA40D83B19" modified="2012-11-28" version="1">MGPIRERSNGPRAVRRVEDVYALVRDRLIAWSYLMQWYNGIHVARSTVESALGAKQLDTLARQEYALGLSLAAIFDISGLSDFLRAINRLLDEWEAWSEKGGSKNVVRNFFRPQRAKPKPTAARDTATAEVTIAPVDATSESFLVLAVMPFTPDYFQVHASTCSIMRDVYKKLLAMVLPPTRAGTSRAELAPTLLHNGTLLMMGPADGSAPATDLATDSAILGEMPPGYCLVGEGQKMTSTIIDLLIKVDSRLKVSYLRPDCANSQKHYVSLVSYGDQIARKVLDDELEALTNSLGGGPNVRYSPNFAWTEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W510</accession>
    <name>K1W510_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W510"/>
    <dbReference type="HOGENOM" id="CLU_669377_0_0_1"/>
    <dbReference type="InParanoid" id="K1W510"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="368" mass="42576" checksum="7A907F20081ED11B" modified="2012-11-28" version="1">MPALYGYKTQWNEYPDWPARYDFVVKPPPSSTAVQDHIARADGRLSLVVRYVTVPPVKTGWANFRRPFHPPPVYFQSFGWRDPQNQERTCTREELCNGFRTLVSGYQELYTLACALYAVWDVASFVDSSGAPRSPTTEEQMNLERTYYPQVMRAATAWQEIRFKLFWEAEYMSQYLAHLSDLEDTGKLPAVWRSYPRQVTEKSVDRLFDSERYCMLVSSDRMDDFPFQMLGVIQNRRKGEHWHTMKRLLEELLVPILNSKGYDGEQEVGKYTKPTGRFQAPSSKELLAWNHSPREYEKEKDKRYDLAHYDGILGVRTVSPVLREEAASRPPPYSQVTEGQATIDSGAEAMEETKRKQEKKSATSDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1W563</accession>
    <name>K1W563_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycogen synthase kinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W563"/>
    <dbReference type="FunCoup" id="K1W563">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W563"/>
    <dbReference type="eggNOG" id="KOG0658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="InParanoid" id="K1W563"/>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="392" mass="44329" checksum="DCB03CF40DE584FA" modified="2012-11-28" version="1">MSNLVNGVRVTDDPNRVVTVTAHEGKTGQEMAITYTNYKVVGNGSFGVVFAAKMLPTKTADGTEVPEQEIAIKKVLQDKRFKIMRLVSHPNVVDLKAFFYSNGDKKDEVYLNLVLEYVPETVYRSLRYYTKLKQIVPMLQVKLYMYQLLRSLAYIHSVGICHRDIKPQNLLLNPNTGVLKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATNYATNIDIWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIKTMNPNYMEHKFPQIKPHPFTKVFRPRTSADAIDLISHLLDYTPSARLTAPQALVHPFFDELRVEGARLPNGKDMPALFNFTREELSTRPDLIKKLVPKHAEAELRSRGIDVDDFQPIPLEQLRISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7T7</accession>
    <name>K1W7T7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="8">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7T7"/>
    <dbReference type="FunCoup" id="K1W7T7">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7T7"/>
    <dbReference type="eggNOG" id="KOG3870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030117_1_1_1"/>
    <dbReference type="InParanoid" id="K1W7T7"/>
    <dbReference type="OMA" id="SHFWTGP"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="72"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="501" mass="57122" checksum="3CBBF11C66108EDE" modified="2012-11-28" version="1">MATAASNKNHPSAKAPAKTVLNLGNLPPRQKPNEMRAERAQFPRTPTKVNPNQPPWPAYRGYHEYSFAHATMGVRLPTILAKAINDVYETLNQIYEKEKIVDLLDCVHKMEHLKEDLEENRQLRPIIDDGAGDVTLWNKEIAKYFRGKDFMNAPWLFAEAYKYRRLRECFSLSRYWVDYDVFFRQKCDTFARSDSAVFELAMRFAEPTKDLTPEKNKLMFLELAQICLWGNSTDLSLLIDMTEEDIKALQSTGGDHLAATEKNILGNDLHALADYVLSLKGGRIDFILDNAGFELYCDLVFADWLIQAGICKEVKFHGKRIPWFVSDVTKKDWNWLINVMVYGNLFPEASQEEMDSLRQMGRRWQKYSESGVWSYEEHPFWITGYTFWHLPSEAPDLFQHLQGSDLCIYKGDLNHRKLTYDCHAPMDTPFAQAIGPLGSEEGAPPVCSFRTIKSDVVVGIPSGVGEKLDEEEPGWKISGKYAVILLSPGNPGPKNQIPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7W2</accession>
    <name>K1W7W2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glutamine synthetase</fullName>
            <ecNumber evidence="4 13">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_07932</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7W2"/>
    <dbReference type="FunCoup" id="K1W7W2">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7W2"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_0_1"/>
    <dbReference type="InParanoid" id="K1W7W2"/>
    <dbReference type="OMA" id="DRRPNAN"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="112"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="39688" checksum="FC418215FC24D9D5" modified="2012-11-28" version="1">MSNLIATKRVDLLAPYMALDQGKAVQAEYVWIDGDGGLRCKTMTLENGPPKSVADLREWNFDGSSTNQAPGDNSDVYLRPVSIFKDPFRGGDNILVLCECYDNDGTPNKSNHRAHAKKVMDAAKAEEPWFGLEQEYTLFDADGQVFGWPKNGFPGPQGPYYCGVGAGRVFARDFIEAHYRACLYAGVKISGINAEVMPSQWEFQVGPCEGIELGDHLWMARFLLLRIGEEWGIKPSFHPKPLKGDWNGAGCHSNYSTKLMRTPGKGLAAIEDAIKKLEKRHLEHIAVYGEDNDMRLTGRHETASMHSFSAGVANRAASIRIPRHVGAQGYGYLEDRRPASNIDPYQVTSIMVETTVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W914</accession>
    <name>K1W914_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginine permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W914"/>
    <dbReference type="STRING" id="1220162.K1W914"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_2_1_1"/>
    <dbReference type="InParanoid" id="K1W914"/>
    <dbReference type="OMA" id="REQNALW"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="32"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="35502" checksum="162423C62ACB375B" modified="2012-11-28" version="1">MRPVGADMSQISAGSESSAKLKSDQNADPLRQMLVIGGVIGTGLFLGTAGNLHNGGPAGLLISYCIMASLLYSVMVGLGEMIAAFPIAGGHVSLIGRYSSPELSFAVGWLYWYCYIVLLPAEMSAGAVLITYWTKPSETCTSGVCNNAMWVGLMLIVVLLVNFLGTKAWGECEFWAASIKVITIVGLIIVGIVITAGGGPDHTSIGFRFWHETGGFVQYKGIPGAWGRFLGFFSVLITAAFAFIGTEMSALAAAETSNPAKSVPRAIKTVWIRLALFYIIGALVIGMLVSPDDPQLDLASTAAGSPFVIAIQRAGIRALPSIVNAALLTSAWMIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA29</accession>
    <name>K1WA29_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA29"/>
    <dbReference type="STRING" id="1220162.K1WA29"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887261_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA29"/>
    <dbReference type="OMA" id="LHETHNT"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="310" mass="33596" checksum="6CF267A75DC034E6" modified="2012-11-28" version="1">MVTVIKNVVVVGGSYVGIPRFAVLPSHEHKAFIPYRVFENSLNAVVRAKAIEVHPDHVVLDRSWEGSTQLPFSYLAIATGTRLTPPGTMVSEDKLPSVKYFQEYQNRVIAASSIVIIGGGAVGVQMATDLKELYPSKKVTLVQSRDRVMPKFHPKFNELIMERFAELGVDVITGNRVVVPEGGFPSDGSTFAVKLKDGREIETQLVIPATGQSANNELVRTLPDQINPENGFIRVQPTLQLKDYPNIFAVGDIADTGAHKAARPGMAQAAAVAKNIRSLIDGNKPTEKYTVSPAGIHLTLGLISPVSFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCK5</accession>
    <name>K1WCK5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCK5"/>
    <dbReference type="STRING" id="1220162.K1WCK5"/>
    <dbReference type="eggNOG" id="ENOG502SD7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479131_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCK5"/>
    <dbReference type="OrthoDB" id="2555515at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="61395" checksum="FB78D106744DF1F6" modified="2012-11-28" version="1">MPVRASPRTGRLKPMLRVPPPPRDPNLNGGTPSPGPAKGKEKAKGPERRVLPARVRRAAGGGAEGIRDIEEMVVDWLERWGDIDPAPPESVVVRVTTAPLKGTYAVEDSSVQAGPSTAPMHAEHAVTPTGAASTPGPSAPALTTALSTLAPGLAPGSALAGEGSHVSSALNTPVPGVKRIETPAWIMVKAGEDDAEEARQEMVAGPNRSPSKRLRHGVVGLEVSLRFLNLIRPADLQIEDTSDAYYEAQHRRFEAFEKRQRIREREQLQFNRYKMKARVDLLRNLPQTQWVSMVAAILARDGDETWQRGRRKLSTMGNDWLRRHLIKEGLEVLRRYDELLPKEGQKEKEKEKEKALKGLAASPASSPPPPSTPKPVIKLRLFSSAQREAAAREAAAKEAARKKAEEERQRQRSRSSSLSSLSDCDPSSPASVAATPTPVLSEPSAHSPASVPSPVPLRLKLQRPRSGSLQTTLKWGKPTPSPTKAPPPAKPAPVPAPQAPALRAPRSSTGSASTEASSPRKTRRLSSDSADVTGRRRSLRSQPSKQNALGLVEDDEADMAGVEAEVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCN4</accession>
    <name>K1WCN4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCN4"/>
    <dbReference type="HOGENOM" id="CLU_410599_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCN4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852848" evidence="3">
        <location>
            <begin position="19"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="669" mass="72270" checksum="1D4E56D857FE4628" modified="2012-11-28" version="1">MAAVLLLVCLFASHGGAAVFIEFNRTIYPINPGLRFSPLYSRYVSRPANPNRQDPSSWALEFDLRNVPHLNDSLYLAGSSPAKVSYTFNGTGMEVFMTPLESGPGSPKVSCLTGGRNNTPADTQVRRYGYNQEMSFAAGKENQTTQYRVDIEFELQQRWAVNNITCTYMLPIDDDHKLDMTEISANATAISPSLPISPRNDTWLSGALDASREALSGNTAPAAMSSSSGRLVDLPPNVTFVSVLGPRYMTQGQGGECRFVFDPPFILRGMTPYDVNYTYVFTGNPYSLKMSSSGDAVGAPRSNWPGGTGEADSELPRVINDVHLLNQQLDPRIRYKFAIVDGADSGAAGTNGAAQTPSSCDFTKILLWQSVPDPSRQTNATQATAEGSAGLADARSRSHGMGPGVIAGTVVGVTLGVALLMTLAACLWRRRRRNPYGDLDDIQDDTKATPYVAPLGPASDASLLREESDTSKQPRDASPRRLVRREEDAGALPGNDEVSLEFDVLPPLYREEWNTAVNTRTGEGSRPSGEAVVRPTKRRRPSGPRRVGASNRTDQTPITNEEIKFLGAPVTSNLPGGLGLRHQCLTPEERKRLAGSQVTVRDETSRSSHIVALEDMRLSTRTSFTESSSPGSSEDHKRAGSSQPSGPAVPPSRQAKGKGVMEGEKTPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD31</accession>
    <name>K1WD31_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD31"/>
    <dbReference type="HOGENOM" id="CLU_508242_0_0_1"/>
    <dbReference type="InParanoid" id="K1WD31"/>
    <dbReference type="OrthoDB" id="2596802at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="64056" checksum="D78CA21039EBC6D7" modified="2012-11-28" version="1">MPSFSLLTTSRSIPLLGEVAPSSSIRRRFTLTSGYKPNGSAAFLQELLGHHRLPLPVQVDSFDRSVEDDGDEEYIQPTTVRLPSSPSLLDRMHRSLCHRAKHLVPDPDIDQPWTEETLRLSRLFRSLSEKAASATVPEPWSGNDLSLASYLSLYLLRPLNELIAYMLLPQGILLHWQAQETPDACRFELVWTRGGLNPRQVRLAVLDGFAPHNLTVQDMQALAVSVRLGMIAHTGNQDGGEVGGEGSGQPRVLIRLLHRNLDVILVISSIISAMPPLTATERQKLLLQQEIAKLSAAPAAAILPLTTPTEEVTRTAVVVASQPRVRVLNTLVVDTSANDVSRYELGCGGGYGNGGRRSFPNFCADDRAFNYPEATIRLKNGLRAEVQELQVILFPSTRISKYTIYTRDEAKAAAMHELAAYKGPLADLQGRLVPQLRGIFGSCQSDGVQVWCVMLDDAGDEIKPSERRSNWVQKSVRKAYADLHAAGVLHGDVQWRHIRRLGMSKALQLVDFDRAQLRSAGMSEEDWEVLTRMEKDCVEILLECTIPCSPAKQSTLRRDQSIKRRKPVPSFEPLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD66</accession>
    <name>K1WD66_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD66"/>
    <dbReference type="HOGENOM" id="CLU_1876896_0_0_1"/>
    <dbReference type="InParanoid" id="K1WD66"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="136" mass="14934" checksum="E2866189896F03E6" modified="2012-11-28" version="1">MTTMQARVRTINHAAISIHSVVLASAWLLVREPGGKIPRAIAQLRTWAAVLAERLDKIRPQDTESTDPEVLQHHAEMMLRCSQLKIKVGHIRTLARSLGGFKDDVEAILDALEIINQAMMTEDSSGGVKSEEGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDY7</accession>
    <name>K1WDY7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDY7"/>
    <dbReference type="STRING" id="1220162.K1WDY7"/>
    <dbReference type="eggNOG" id="ENOG502SFMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302855_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDY7"/>
    <dbReference type="OMA" id="FWTDPCI"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1152" mass="122901" checksum="C47C9B313EF47CEC" modified="2012-11-28" version="1">MPAPAAIESPAPARYTVHGDDDSMGDHAVADVTFSDLGFSSSDDEAGVFFGTPKAIERKIVASLSKTIPPSPASRDLALTAASGSSPSRSPAVKRVKKRDSREFLRRKTLLLAHPEVSPAEKVWEGNFYEKDPPTTEEQASPSSEGSNHQSPNILDMTTSLITTADVSPASSSSSLDLDIFNKSDTSLESDFDKENTDIPEPLDYTPEPEYIPDEPEPTAALTLGMREAQLIDLDSSLQLDLGGLNILDVDDPEVGHDLRPMESTADLLGSSDSESGDSSFRSTTSPMSSGAIETSLQTPAPVDVSQEPEEPATLPDSAEAVAALVNLVEPAVEEQNKPLSELATPLKALGTLEVEDLRRSTLKPGPRALARVSDASIVGSETSFASDLDSPKARGPVQIPVFSVPSPKHTPVRGLAPSSHDTFSVPEHSNDFALPSIDSPVPSPKPRQKPVPIAVITPEARQRVYEALPPSQRPSRILKSSHIRTSSKSENRPPTPTKEEVETKERAQIIRSELDTIFKAKCAGFGLPRPQNASTSMASSTTIAATPRRPVQEPVKGLAEATKVSPSKKVVKKALTTSGLPRPTSAIPTAKRRPESSLSRPTASTAAKIAPTARPPLAAARRTATTVPSRTTVPVTAVGRSSVMVPVRPAETPVRMKHAYEQPASVRTRPLAVGVGTRPTLGPAARLVRDPTSGGLVYATSGGQSFSAEFSVAPPRSPVAQFAPRSPAAHFTPRSPGFSLGRPTRPGVGPTPTPQRNFRLGTASRTGTLMGARRQPSPTKSSSVPTLLVQRDSDDPSEGSDSGSASGSKDAPKETQAANDTPKDQSTEAPESAETSDETVPAPESAPGHTDTEPNGSSSEPNGHAETKPSEPEPEKQKEKTPSPPAQPAPEPSTPVSASGRPRRTPKPVDRLVQAPVPTKAAVTPSIAPGLSEKELKTQTQRNTMRNQVYFCAIDRQIVRVPGPRPPSPTGSIRTLAEKEEEEQKAERDARARRRNRGSGDPSSSDDEPPVIEKVTVDSAPGDEEGETWKTPAKKRKRITSDEEDNTRNVRWDRALTVFRGGLGEAPRLRARSTEEGHDSLDTRRTASEEPARSALKAGAQIQLDRNGNAVDRPVEKLKRQKITVTAVFYDGEEPVPEPAKNTRSKKKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEP8</accession>
    <name>K1WEP8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gag,protease,endonuclease, reverse transcriptase,RNaseH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEP8"/>
    <dbReference type="STRING" id="1220162.K1WEP8"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806952_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEP8"/>
    <dbReference type="OMA" id="IHITIDS"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="87"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="344" mass="38564" checksum="2462262AA022D866" modified="2012-11-28" version="1">MHFQPRPVTHDDHNCGDHPLDFVPEVKPSDTNPDNHFALASIGLYIASQLPTPGAPRNYKQAMRTPEAPLWQEAYDKEISQLRERGTWRECVTPPGARLIPSVTVCKEKKDKDGNVIGRKMRICAMGSRQVQGRDYTDSYASVCDASVLRGMMAFAAHHDMELEHADAVAAFLNPDLDQPVYMRFPAGYKPLDPNADCLQVVKGLYGLPQSGNLWQEMATKALVSLQFSPIPQSDCLFQRDVGTPTQLRVALYVDDMLGAGKTHALLDQFWDKLNEKFAIVKLGPVDHLLGMTIQRNRLTRTLFITQAPYVKEVLGEYYSISKPVEGDIVLTQPWMAQYEVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF28</accession>
    <name>K1WF28_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF28"/>
    <dbReference type="HOGENOM" id="CLU_1611971_0_0_1"/>
    <dbReference type="InParanoid" id="K1WF28"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="17953" checksum="9EEB64D3CCD30FD4" modified="2012-11-28" version="1">MTVINLPQPSGHKPAPATYHAPLVHFPPYNPELDFDFDDDEEDDAEDLSSPPASKPRSQPISITIVPSMQPKRTRSRTRATQSLPSSPRPASGFAVMQRRETTSAGRPSMHHRGTSVSSSSSASSPELSTASVSPSSLPKASYFYPLHGRFPQQPVQRKPSYAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF87</accession>
    <name>K1WF87_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF87"/>
    <dbReference type="HOGENOM" id="CLU_1866534_0_0_1"/>
    <dbReference type="InParanoid" id="K1WF87"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="137" mass="15507" checksum="3D3ECB21CE8B83D0" modified="2012-11-28" version="1">MGRHYNSRHSYWDDDYRHGHGHRHGYGYATPVASMPYVDPMMGMGMSMTPYPMYGGYATDPYAYGGYPYGGYGYGAGYGYGAGYGGYSSYGYPMMGGMVGGMGYYEPYGYPPMVMEPSYYHRHGLLDHFLRLGMYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHM3</accession>
    <name>K1WHM3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHM3"/>
    <dbReference type="HOGENOM" id="CLU_042327_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHM3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="524" mass="56608" checksum="3074E0A99DC66CA4" modified="2012-11-28" version="1">MWWLLAVARDARAADLNSSVFLEVGPYSPMASLDTLSFKENPYTGLFDRQKLNVPVTINSTFVGTAFELSGALTLPIWSPDINTALATTTSGGYSNATGVQNASADGVIVAMSGLDLGLHDFTTTLTETVNCTFRALRFQVPFLSQARTAKQALHAPQLLVIGVFVQIAGTARVREAGWHVLAIQRARQHDPPQHHRADYELLLVLCGRQSAPSLVEQTPVLSGRRPSIARRRDLLRPTSRPNRQLSTSTPTVASRGSLPTRSSGRYRRGEAYTRKPNVTEPQGTDPESQADAASGKPKSAPVGAIVGGVVGGVVGLLLFLAAVWWWRRRRRSGSDDASLIDDTKLASEPESASDRDTKVPPPPSWQDSGSIDGVSPSDHLSDQATSIMPALGSEIGTHSGSSASKLLPPEAPPSKLGDRALEHKVELLHHIDHSRVGDRSLEHKAAFLPQDEPGPSQQRSLPRPPLVQYEQDAEDVPSEPLIFPPRYKEAWGERREQSAAGNHIVDRESVLRADDGGSGRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMC9</accession>
    <name>K1WMC9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMC9"/>
    <dbReference type="FunCoup" id="K1WMC9">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMC9"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="InParanoid" id="K1WMC9"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="184"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="474" mass="52187" checksum="054C7B4C4A285F46" modified="2012-11-28" version="1">MVAAFDIPQRPANVGIKAIEMYFPKRCISEEALEEFDGVSKGKYTIGLGQKFMAFTDDKEDINSIALTVVSGLLEKYNIDPKSIGRLDVGTETIIDKSKSTKTLLMDLFAEHGNHDIEGIDSKNACYGSTAALFNCVNWIQSESWDGRDAIVMCGDIAIYKEGSARPVGGMGACAMLIGPNAPIVMEPVHGTYIANTWDFYKPDLNAEYPTVDGPWTIRAYLGALDNAYSTYIDKANASRARAAKKAAASGQANGTANGTSSHDGINQFDYVCLHSPYGKLVQKGHARLFYNDYLRDPSNPEFASIPAELKDSEKEKTYMDKTVEKAFMAHAGEHYKRATDPASSCVKRCGNMYTASLYGALSSIVNNIPADELKGKRIGMFAFGSGCAASFYGLRVDGDVSEIKQKMDLTKRLDAMEVVPCQDYVDALKLREENHNAVEYVPKGSIDNIWPGAYYLDNIDNLFRRYYKKKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMJ1</accession>
    <name>K1WMJ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMJ1"/>
    <dbReference type="STRING" id="1220162.K1WMJ1"/>
    <dbReference type="eggNOG" id="KOG4086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2160181_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMJ1"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="12866" checksum="9970A3883DF67C52" modified="2012-11-28" version="1">MQQLPTILPPPPLLDGTVPTRSPEKHANLVRFQSELECLANPLYLHELHLQKYLEDPAFLEYLKYMEYWRKPEYVRFIVRAEKEEVKDEPKEEGAEKDAKTTNAEAAPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPX7</accession>
    <name>K1WPX7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPX7"/>
    <dbReference type="STRING" id="1220162.K1WPX7"/>
    <dbReference type="HOGENOM" id="CLU_727992_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPX7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="5">
        <location>
            <begin position="168"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="380" mass="39635" checksum="D4400A9ADD3E83FC" modified="2012-11-28" version="1">MNGRVPASPTPVYAGPPADSRHACLVCLASPSREPPDPAHAPHTLGSWAACAAHECSVIGDPMGWFVGHPSWCTNVFRTRLTQPFAPLALLYAGVLRLRLRRQRLAQAPADPVEPRRTPLLALEGMGSPPTVLPYLLDFHFPGKMKFFAISFAALALAVPAFAQSGAPAASAASSAAAPPASSAAGGGGAPKLPDCAMQCVLGSVKAVPNCSNPLDPKCICDERFVNAATDCLVAKCDHKDAIPALDIAKQMCPDLGLPDLSKLGDCAFECVISTLTGAHCKGPLDKQCICGIPFGLKAAGCLALKCALDGAGEAINLEFGICRPLDKPGCAATGIWALTDLRCLLPGLFKKGDNQKREVRYATPAALYHRALLEAEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQ74</accession>
    <name>K1WQ74_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQ74"/>
    <dbReference type="HOGENOM" id="CLU_2706560_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQ74"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="73" mass="7581" checksum="8577DE6C3A930DE1" modified="2012-11-28" version="1">MSTDGPDPPANRPFGAILGSAAAETLGFPYAGSPDWLESVPTGTNREGCAGDDFEAVVGWPVGIEHIDGYPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQI5</accession>
    <name>K1WQI5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQI5"/>
    <dbReference type="eggNOG" id="ENOG502QUQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394931_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQI5"/>
    <dbReference type="OMA" id="YARRREW"/>
    <dbReference type="OrthoDB" id="2574141at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="76700" checksum="1CA2BA69A1EBD630" modified="2012-11-28" version="1">MPTQPPTTTAQLITLVVVELRLPAHPHNDCAVHAADGVTVAASTSCRLHGTRRGSTLPPQHRHATGVVYRCEIDPQAQHCIECIATDELCSWDLPPLGGLLNKPPRRPPAFTVSDSETSRGSSLGMSRQSSVTSVETPLKSRERTFAVHRSGPSSIPYIIHSMPTLPLSRTLSEYCMDKGFRMVRTEGLDGYISVTSEVDAQSHPPPKGASSWSEAVDGLVADYIDHIGELLPIVTASEAEQAGPVLRHAMAAVAATRGVVSPALFEAMRASLPYELEQNDVHFVPTLENVQTLLVLCLVDELADRPRVSPVSVQRDRLSAAYRLALDLGLARSRLEREVRVWKCLQVIDTWRAAKDGVSMLHSFPSSSDSNSGASSTMSSSINSPTISPSMSSTPLSVSVLTKASVGHVYGNTFFERLYSLSKLLARVLTLIYGPDGVTETDAPAMRRLQHDLAVWRDSLPISLKFDYNSAKFQTVRTQRRVQESGLLLVFYTGVRFLFFRPLMPWSFHLPKKFKQFVSISTDEWVDLMKLSRYSVDFVVNLEEASELLFFFGVYTLNLSCLVLYHTWARRGEWEGSIYLDKARRCYDRLVHGPGTHLPFLKRDMSTIEMLLGITELSRDQFGAHGVRGLNPTPGVLNSLAESTVSGVMMLREGDGEGFIMVATPEAARDIQDLPPGTIVLGGMSPLPGESPPIFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRV5</accession>
    <name>K1WRV5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_01940</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRV5"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000820_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRV5"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000636">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="191"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="1384"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="664"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1060"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1445"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1616"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1073"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
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            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1192"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1445"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1634"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD03714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2516" mass="274549" checksum="B8743C0DBE1438F7" modified="2012-11-28" version="1">MSDPFAIPPHRQSMDDQAARYTPPFSPPSGHSYSMSVNQVPSAHSRPSTASTRASASAASTSRQASGRPSAAQHIASEFGAYLPSEGPSSTAGTRGHTHRASHASTTMPIGIPSQEPTAIMSGAHASSHSHSAAQQHVPGQQRKRQSHHGLSSQASPPRSEYLSDEYVLHPSVHTFKQAHPNRPMIALGQYILLQTLGEGEFGKVKLGVHSEYGVEVAIKLIRRGQLDEDSQRANKVEREIEVLRQLKHPNIVRMLDVIDTAKYIGIVLEFAGGGELFDYILANRFLKEKDASRLFAQLISGVDYLHQKHIVHRDLKLENLLLDKHRNIIITDFGFANHFERDEDDLMATSCGSPCYAAPELVVSEGLYVGTAVDVWSCGVILYAMLSGYLPYDDDPQNPDGDNINLLYKYIMSTPLNFPDHMSRIAQDILLMMLQPDPTRRCTIPQVEDHPWLDAHRALFERTIEDHERIFSENMLRKSHMAKRDLAQRRRLQQEAKLAKALARSQAAMGSSGGNMFDQRRAKDHTRHRSALPSTSTMPEYLYNAGGHTSVPPGVAVYEQDVLYQQQQHLLQQQRMDHPAAAAPVPQDMLPTRARTQRTPPKPRPESVNYSDNAMVQEVVMPRASPEPSRVPAPAASNRHTIQVDYGSDMWNRVQAQFAAGDAAVAEGMSEDRSPSTTSVPVTPPKQIDAQQIDEPRSSDMDVESPATEAEDARMSEPEPEPEPQQQPEIEVPTATPSPAAETPKMAKRQLSDVEMPLATSDAPDVEVPPVVTTLPIADPDAPPQSQSAPPALPPSTPSKRSRESENGDAIMAEGSSPTPPFSPSTPRQISAEPDQIITPRTEVPQRVPSTSRPHAKLPPGAATPDKSPRDLPEPEETLAEPSAAPSETTTSVNKTPEPERTQSQQGRKRPARSRKGLSLDKFSLAKLLGQGTPSELSKDGGSPARTSQRTWSQGHGRSFSVAQPPRQRNVSESMRDSNPRQRPRTLLLSPEEAATATDFSGSTTSSPVIGQHGIHPASHDQRSSTSAVTVDADTARPASTSTAKRVMDWFRRKSTAKDTLHNIKNTGVADPSSSGRQSMTLERNAERVASSSRPSISADRVVTASTGSTLSKPSTDRLATAEPSTKLEAATPSPAIVIHESSPAPAPAPVVADDDDKPKPEARIPLAPANNLTNIDDKIMLNPNRVVPTRSKSQHVPSSLSKDMTNGTPALISARQAAEKRGHDSSGPLSADENKLRVHTGLVDQSALSSHTPAEIMEEVLRVLHGMGIEVKQEADFRLRCTRVRRRKAGATTGLSSGAFSLVSAAAANRSEGRGVPSTSSGGGGGLGGLKGMLLRRGSSYSSQHSSVLARSESDLLNSVNNSGVQSPSLGPLPEPLYGEHAIDNGDEVRFAVELCRIKNLHGLYLLSIKRLRGSVWSFKFIYQTVVERYHKLGDELEHYCQHRDPTTDKKSTKMATPGDQPSRPASVMSTASVSASMTPEQLLKAPSHQLPLPLLLSSLAALPAATRLVTCANLVLSGKFYDQVVLRQIIEVGEEAGAAEAQQFEDDVRSRLEAEHVRRDESAKGWAQYKSEDVRAAAEAVLGTDQARTAAVHCLAVLREARRRIDTFDAFYAPRTPKPKTREPSGQSADIDLDDPWANAEDEDTGVLDDPWAENDPELEPQPPRPQSRAQSMMQVEPPIDAATFVLQDIVLSALGLATAAHMKALRIVCQRHSEEIWPYRLSIIESVPGWVSPATDDMQALLPASFTDGEKSQWPPNATPTEVMFLDVLRPQYGMEASNPLPHDLLPTAQHEALSDEALSTWYQHRVMALDELGLLDAQLAWVQHGAALGVSGLDIIGEDLSLLSRLIYDSGLAPQQQEDWSLELWRKASEETIVRAYLSNSSQASIVNDIKRLVLPYLYVLQSRSERAGNNDPDLVERMLFNAILELPLSLALPCFEASKATLPMHQRLIKDDQAVARLALAILYGSDALNAWGTMSAIFECLPVWEDSSTGDKELDSEAVATTLESIASFMRPSTSHQSMHAPKDLFMFFRPLPFSSLSKAIDILDLDLESGEILNKWNLNIYLRELLQFAYDHDEQHRLAERLVRKQVNSSNASERMWLDLWQDMISKKVVKTLKPEGYFTSQDLEEAVLKTSREFFMRAETGNIHTGEMKLAYDCLSVYGAETPAIKREKEFIEATSRLTTFKALSGMTPSEIRFTPNKLVLIERIVSTSDDIYKHTPIILELVEKLGYRDDKVAKAQVYGMLCDSAISNEEWEIARDYIGILIDMAEPELETAPVAPPRPGSRASLSRQVSRASMRSDVSGFEPPVRDPATEASMIRQVTWRSCLALGRQSEYQNIPDRIALLAQAIALCPPEEVSAILPIWRSAEQLVVNNPKLLEPPADSGSGFTASSLSSGIGSVASGLGSGLGAMSGSAMSAAGFGGFGGQGQGQEDDQRVLGSRRAARAAKLAMDFGSNLRSFTGSPAQGEERDNGDVRGGLVADVDAAADMGRRALVKGVGWLLGADEQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUN2</accession>
    <name>K1WUN2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_01146</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUN2"/>
    <dbReference type="FunCoup" id="K1WUN2">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WUN2"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_2_0_1"/>
    <dbReference type="InParanoid" id="K1WUN2"/>
    <dbReference type="OMA" id="CRIFHIA"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKD04574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="323" mass="35331" checksum="CA2B79F6DE1FF586" modified="2012-11-28" version="1">MLLVYYSEGGLTSVVLPASAGKLLTSLGLPGWAGNMVVDLGGSFSPCEANNGGFLYYVYLLMLPTFTTNAINILAGINGVETMQAMLIAMSVALNDLLFLPIWSTRLLRLIGAGIPEEGRLLDWAAGEVVKRHLMSLYFMLPLIGVCAGFLYHNWFPARAFPGDTLCYFTGMAFSAVAMQGHFAKTLILFFMPQIFNFVLSCPQLFRIVPCPRHRLPQYDAETGLLSPSLTVFDSPASLKTRITLQLLELLGLTTLQRAPADKHEVIVSATNLTLINWVLVHFGPMREQTLCLIIGAIQLSSTALAFAIRYGLGTLVYGGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVF8</accession>
    <name>K1WVF8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA clamp loader</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVF8"/>
    <dbReference type="STRING" id="1220162.K1WVF8"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_5_2_1"/>
    <dbReference type="InParanoid" id="K1WVF8"/>
    <dbReference type="OMA" id="PTESEMI"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="201" mass="22721" checksum="6EB929018BEDD04F" modified="2012-11-28" version="1">MFRPTTRHNIPRTMEKYMTNMRLIMCANSTSKIIAPIRSRCLLVRVAAPTDDEVAKKERFTLPPSASDAIIEAADGNLRKALLVMEAMRMQNPDLNGDVDVAKPDWELYCAKIAESIMQEQSPQRLLDIRGKIYELLSHCIPPAVVLKTIADGLVARVDDPLKPVVVHWAAHYGSKKIFHIEAFIAKIMKVVKESFRKILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWS9</accession>
    <name>K1WWS9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWS9"/>
    <dbReference type="STRING" id="1220162.K1WWS9"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="InParanoid" id="K1WWS9"/>
    <dbReference type="OMA" id="GWWVPRE"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF393">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="510"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="610" mass="66729" checksum="6EC0E19A4358CF9B" modified="2012-11-28" version="1">MAAAAAPPKRTPVAECDKILCKPGTPFELETVEIAGRPTTVWKNAPKSFRSYLLEKMDQYADRPFLNAPVPEPGNPEDREIFTFGEVKKYAVELAAWLVQRGTRQGDNVGVVGFNSAYWVIAWTAVHIIGAVPVMVNAATQPDSQVHCLKIARPAIVLCDAATAAALAPHQVTLADAGIQQIYSWQRTEHLGKILGIPFVDFKQLDVPPQLTQPILEGRGFGLEDQTPESDGNIFFTSGTTGYPKAVLSSQRAALHNVISSVYGFFRTGMRQGATVEQMQEMVLNAPPVQNVGLMGVPFFHVTGNLSILLKFFTDGNQLVLMRRWNVDEAVRLMVKYKVNVIGGVPAIVLAVMQSPKLPKDFPITGVSYGGAPSPERLAGDIKKRWPEIGLASAWGMTETNAPHTAIAGEDFVERPKSCGYPLPVAEVRIVDPDTRAVLKPYERGMIQARGMTMMKGYLNDAAANAKSFDKDGWFETGDAGYLDNDGFLFISDRFKDIVIRGGENISSEEVENAIYQDDRIAEAACVAVPDDLLGELVALAVSLRPGAKATPEEIMKMAAGRLRSHARPAFVWVSEELLPRNANGKLIKTEIKKTVRELYAKRPQQGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWT1</accession>
    <name>K1WWT1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWT1"/>
    <dbReference type="STRING" id="1220162.K1WWT1"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_6_2_1"/>
    <dbReference type="InParanoid" id="K1WWT1"/>
    <dbReference type="OMA" id="ESNTICR"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03047">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000039">
        <property type="entry name" value="Glutathione S-transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF19">
        <property type="entry name" value="DISULFIDE-BOND OXIDOREDUCTASE YFCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="85"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="24170" checksum="BD5F267DB24CB557" modified="2012-11-28" version="1">MITIWGRHNSNNVKKALWAAYELGLDFESKIVGGPYGGTHTPEYLAMNPMAQIPTLVDDDFVLCESNAIVRYMYAQYSAEYREMKPKDKAVGDRWMDWCSSSFAPVYRDVFWPIVREKEENRNWDSINKAKDKCEELLRIPEQWLETHDWFSGDEFGAGDIPLGCFLYGWFEMDIERKQKTPNLEKWYARLKARPTYQRGVMVPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWX8</accession>
    <name>K1WWX8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWX8"/>
    <dbReference type="HOGENOM" id="CLU_792709_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWX8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="350" mass="38422" checksum="161777BC8A9F6C3E" modified="2012-11-28" version="1">MTNTNLSNSLGLRGLSLSDNASTGKDHRLDSSALPSLEGFPAVVDSILYQSDNSTLLACRLVSTYFRDQADRALFDESLITDLSKGDIVIKSKGRVLPCFHPDSPEEGKIKTLSSTVVTTCTAFSHYQELAPLLIKYLPCKGVLIIYGMPLAEGHIKFPKIHSLQVQLDLRRKDAMTPTATIEHESECVAIDLELSLMEPTHWWKLIPFLRPNSLHCAHIWGHGKPRMSWINLGPCTPVPGQFPGTEWLDERNDNWFVHVSCPDLKGGGLNEAMRTGVRHSLAIVLASPDERILDSAVGSPFWGYEGPSRAVIMAEAQARACEEDASNSDETVTSPSVGADELIRSCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1T8</accession>
    <name>K1V1T8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1T8"/>
    <dbReference type="STRING" id="1220162.K1V1T8"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546301_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1T8"/>
    <dbReference type="OMA" id="MKQGWQP"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="411"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="482" mass="52208" checksum="18C17873E7C3E625" modified="2012-11-28" version="1">MPCPTGDAAGRGGSGNQSEWTWAPELGVYHHSASGMYALPQGDGWRYLTSEELAAHTGTSGSKNDNYEPEEGEIEDDVGWGALMDPEKLARIESTKNPVYIASPQRRDPYGRETYSDGTPTAGDPLLAHEEGDDAKHLLRLVVKRSQVLEVGSVAVLDARKDGTQLGRDRGAEARVRIKEMEVSKTHAVVFYQAPSAPRSPRRSSRSPSPYGSRSRSQTSTPAPPKEGDSGWYVSDLGSTLGTYVAHPGEADATRLSEPKCASPPYALKHGDKLTVGRTTFAVHIHQDWPCGSCQLSGNAQIDLEEGRLRPCPKSATIPEVSSFELDTFAMSGNGTRKGRQALKRRREMDALRDNLLGEDEPAPKIRAAAAGYVDRSAERRRLHPPSPPRRRDVEEARPVVAAGPTGPTGPSEAARKLLAKQGWSEGQGLGRTPGRADPIVPVVRAERAGLGIRGQVADQPGQGGDWRQRGRQRRWDEVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2Z7</accession>
    <name>K1V2Z7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_07298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2Z7"/>
    <dbReference type="FunCoup" id="K1V2Z7">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2Z7"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="InParanoid" id="K1V2Z7"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC98284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="41311" checksum="C88B5D6D8AE9E476" modified="2012-11-28" version="1">MTSMDLRVGGKYRIGKKIGSGSFGDIYLGVNIVSGEEVAIKLESVKAKHPQLEYESKVYKSLAGGVGVPFVRWYGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRVEYIHSRNFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHLHIPYRENKNLTGTARYTSINTHLGVEQSRRDDLESLGYVLMYFLRGQLPWQGLKAATKKQKYDRIMEKKMTTPTDILCRGFPNEFAIYLNYCRSLRFDDKPDYSYLRKLFRDLFVREGFQYDYVFDWSVQPPQKSSDNSAGMNDTDALMQAQQKRRIAAEAQMPVSQDPKLESQRQLRSQTRNIAREQSGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V437</accession>
    <name>K1V437_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V437"/>
    <dbReference type="HOGENOM" id="CLU_1344089_0_0_1"/>
    <dbReference type="InParanoid" id="K1V437"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="204" mass="21258" checksum="5C830AE14CD48A56" modified="2012-11-28" version="1">MSAPSHPSQQATEPWSSDNNQPPPSDQWSTSEHGVAETVEAVENVIIADDSKPLPPLPPLPPPPALSSIPPVPPPPPNRNSSLSPTEPILILPEPSLSPPSTVPRTPLPPLPSVKAAIPAAMCEAPAFLPPPSPSPDEYNYPATPPASAETHETTDASGVGEGKGAQGGSGGGAKDTDREQMEAQMRKLREEIAALQRDLEGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4X0</accession>
    <name>K1V4X0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4X0"/>
    <dbReference type="STRING" id="1220162.K1V4X0"/>
    <dbReference type="eggNOG" id="ENOG502SBA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088334_1_0_1"/>
    <dbReference type="InParanoid" id="K1V4X0"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="275" mass="31358" checksum="856808782575768E" modified="2012-11-28" version="1">MRHQSKSKRRQSAMPGEQALPRIIIEKEEPWLRVQENVNRALADALEVRLSSLPGGAKGEQAKKLRPSLEQHLASIRNRMWEMTKPNLRVNGFNYEDFVETTEPFDESLDRQIWALNTERVNWETKVVEKRRIKAGEVANLIDDLELRRDAAIWKPSEEDERQELEAQEAAKNVSSADIAKPERHAEVLETFGKVVSNLSELASVNLDGERELTSDRSATVITSRAGASCARGALTVTVMASYRLGFRVSVYLYILYYQSIILQPRVTRVLARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V600</accession>
    <name>K1V600_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V600"/>
    <dbReference type="FunCoup" id="K1V600">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V600"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083737_0_1_1"/>
    <dbReference type="InParanoid" id="K1V600"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="26681" checksum="3E2E531C04EC40BE" modified="2012-11-28" version="1">MATTKSPSPQMELNPRGIPKAPFVLTFQANVEDYVGTNSVEPIIKTFQETSAKYRYMELNLQQRRKALLAKIPDIEQTLSVVKFLQARREPKPAASDEKDETGSMNSDDIDALLDGDDEEAEEGAEQKPLKTLFELNDTLFAEATVQETGEVGLWLGANTMLLYPLAEAAELLEEKLSSAKKSLKEAVEDLEWIREQVTVMEVNFARVHNWDVKRRREQKKHESVMGHKDEDEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6V8</accession>
    <name>K1V6V8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05933</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1V6V8">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V6V8"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="InParanoid" id="K1V6V8"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1297"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1502"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1545"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1581"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1619"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1682"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1740"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="12">
        <location>
            <begin position="253"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1781" mass="203226" checksum="3AE3BAA815FC84C4" modified="2012-11-28" version="1">MSYQDGQKPSGYSPTSEATDPFNPPQLGYGHQEGGVPHPSTGGGQYQPYYDTESDIGARYEGGGMGRETWASESAWSGNDAPNYPASDASHQQGYPSRASTPTYTESKEGHRGREPYPSWTQEANIPLSKEEIEDVLIDLANKFGFQKDSCRNIYDFLMIQLDSRASRMSPNQALLTLHADYIGGEHANYRKWYFAAQLDLDDAIGAVNNPGLSRVRSVARRGKGPAPATAREKSLDSAMSRWRTAMNNMSQYDRLRQVALYLLCWGEAAQVRFMPECLCFIFKCADDYYRSPECQNRMEAVPEGLYLRAVVKPLYKFLRDQGYEVVDGKFLRRERDHDKIIGYDDVNQLFWYPEGIARIVLNDKKRLVDLPPAQRFMKFDRIDWNQVFFKTYLEKRSFFHLLVNFNRIWVLHISIFWFYTAYNAPRIYSPADTGKPTRAMAWSMPALAGAVATIIMIGATLAEFSYIPTSWNNTSHLAGRLVFLGIVLFLTLAPSIFIAFFNQTSGLSEIFSYIQFAISVVVVIVFSVVPSGRMFGDRVAGRSRKYLANQTFTASYPALSPSARATSILLWVLIFGCKLTESYFFLTLSFRDPIGVMTGMVIQQCNDKYFGHNLCKNQAKFTLAVMFVMDLILFFLDTFLWYVIWNTVFSIVRSFAIGMSIWTPWRDIFSRLPKRIYAKILATADMEVKYKPKVLVSQVWNAVIISMYREHLLSIDHVQRLLYHQVASDQPGKRTLRAPAFFISQGDSKSKVEFFPKGSEAERRISFFSQSLTTTLPEPLPVESMPTFTVLVPHYSEKILLSLREIIREEDQNTRVTLLEYLKQLHPIEWDNFVKDTKILAEESQMYNPSNPFASDEKEETKRADDIPFYTVGFKSAAPEYTLRTRIWASLRAQTLYRTVSGFMNYSKAIKLLYRVENPEVVQLFGGNTDQLERELERMSRRKFKFVVSMQRYSKFNKEEHENAEFLLRAYPDLQIAYLDEEPARKEGGETRIFSALIDGHSEILPNGRRRPKFRIELPGNPILGDGKSDNQNHAIVFYRGEYLQLIDANQDNYLEECLKIRNVLGEFEEFQVSSQSPYAPQGHKDFKKFPVAIVGAREYIFSENIGILGDIAAGKEQTFGTLAARALSFIGGKLHYGHPDFLNAIFMNTRGGVSKAQKGLHLNEDIYAGMNAFGRGGRIKHSEYYQCGKGRDLGFGTILNFQTKIGTGMGEQMLSREYYYLGTQLPMDRFLTFYYGHPGFHINNILVMMSVQIIMLTLLFLGTLNSSVDVCHYNAQGRRDDNFATCYNLQPVFKWIKRCIISIFIVFWIAFVPLFVQELTERGTGRAIIRLAKHFMSLSPVFEVFSTQIYMHSIVNNLTFGGARYIATGRGFATTRLSFSILYSRFAGPSIYIGIRTLILLLYATLSVWVPHLIYFWITVVGLCIAPFLFNPHQFSYTDFIIDYREFIRWMSRGNSRAHTNSWVGYCRLSRTRITGFKRKRLGLPSEKLSSDMPRAPWRAILVGEIIGPICMAVIMVICYLFVKAWPDPNDATGITVPALLRLAVVALGPIVWNMAFLLVLFLFSLFLGPCVNSCTSQFGAMMAAIAHFGAVVGMVAFFEFLWYLERWNASHTCMGVIAVIAVQRCIFKILIALFLSREFKHDETNRAWWTGVWFNRGLGAHVLSQPAREFIVKTIEMGLYSADFIACHLLLLLLTPPMLIPYFDRLHATMLFWLSPSQQIRPPIYSLRVRKQRRKIVFKYSIVYFLVQAGMVALIVVPVVLKTAGGLAPKKAPFNGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V768</accession>
    <name>K1V768_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V768"/>
    <dbReference type="HOGENOM" id="CLU_1788176_0_0_1"/>
    <dbReference type="InParanoid" id="K1V768"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="145" mass="15227" checksum="9953FCABE5BCE721" modified="2012-11-28" version="1">MPSPPQIVTTDLDGPQSPDAVNNSPHTPVNQHPANDPSHLSPSNQGALAPGSPTLTTSSSVHFNEDGSPTSQLPPSYHSDAGGATTANNSLSVPDSPSKHKRKWSIGTWSSNGKERDLSVVEPTESDSDEDGDKKKKKKKAVQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1V982</accession>
    <name>K1V982_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V982"/>
    <dbReference type="HOGENOM" id="CLU_839886_0_0_1"/>
    <dbReference type="InParanoid" id="K1V982"/>
    <dbReference type="OrthoDB" id="10676419at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38232" checksum="536F96378DB13A26" modified="2012-11-28" version="1">MTAILDHRFYPHIIDLIWSHMDHESVAASREVCKGWRKRANRVLQRHLTVRPAPYPDTDDFLLSVKSFTHPDVAYPSFLVQRDDAIHSGFPATVTGMLSDESLKDLFSNIRYLDLQHVRGMEETAVLLSLVMGLKTHYGLRATRNAMQLYGDVYPEADTGVYFVNSRETTEGNPLVSMYARSLVINLDQPPISYGPLPDDEVEDEGTLWEWLSSYTPGRLKQLTLVFHPSDEERGTFQTYAAPNPRAVAGQTIRWLGDRWISATTLLVGMERFFRSMDEYREYKRQMREYAAHQAERITGTPKRGRNLKIFTHDEYRKRIGDATYTLYTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9D0</accession>
    <name>K1V9D0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9D0"/>
    <dbReference type="STRING" id="1220162.K1V9D0"/>
    <dbReference type="eggNOG" id="ENOG502R3FC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050876_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9D0"/>
    <dbReference type="OMA" id="VWEVTMK"/>
    <dbReference type="OrthoDB" id="3255427at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="43356" checksum="26D74FE4E046A170" modified="2012-11-28" version="1">MPLPKFGHRRVKSSYDQPPTPPVLVVPHDDTPPQSILKSPSLSPTTTTDTRRSLRHDSSALSVDSLSRDFQRFDTKDSVWSVDEPPSPRTRSSTPGTSISSTAGMCPLPESTEQNRFPFFSMTLSSTSTLSFIALPVTMRPLVLDAINRAWKRGIKSTNSVEYAPELMQWHKKKGCDGGVWEVTMKDNCWMPKSEDKVASKRIILYLMTAFAKCGYELASSFTATIKDTGKDTLMFNTCTPDPDPVFMGVAFYGSDRIWIIDAEADVGQALEDGIKATWVDGVRDARVRERHCRELRLRNNPWTAHNASALISARCIQVTIMKLVTYHSNYKYVGAINMTDRDEPGMPLTVYRLDTSTPSMPFPKIEPISDQARQSMGVGLSHSRSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9K2</accession>
    <name>K1V9K2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000337">
        <property type="protein sequence ID" value="EKD00635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9K2"/>
    <dbReference type="STRING" id="1220162.K1V9K2"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439531_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9K2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="471"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="622" mass="68408" checksum="1D593344F057A4D2" modified="2012-11-28" version="1">MPPSGVDFLHRLRSDPKSHHITIGPAPVQFHSPRDPNAPSQSQPSPSPHTTPESDEHTPELEVDDPRELYDDSPDPLPEPAQHDGSHPSTPTDDDDPAVAFQTRGHFLDSNRGDSSASPFGGALPGSPKTRVVSVAPDAPSPRRVHPQRPNGAPKRSQSDFGKTQTLGSDEIPPADSERSRRIAADGLPPQLSLGANGKADWQCFCVAYAAGMWNPNYTPQPPQGPSGRFSTDVLRPAPHSHSRHPAPPNDSDLRSPTSTNAPPVPLDMQWAAFQQPDSAAVGSLPSEGFYGRNSVANPAKVVFSLPHPEREHVDPFGPTQQPPPRKLSEGLPHTGAMLPAMQAEGGIPRKIDEEKVADDDTVIDTFVQMTLGPREERSTASVAEMDTTDDEEDGRPVFEPPTVDPMEEFRSMPQYAHFIEDFPTITHPTEMAIFYRRFGFLPAPMGPRELDRRKALYNFNILHTAKDANFDRITHICKLMFNTKMVVMSLLDSDTSWYKSTSGLELSQSARVTGFCSHTILGNTDEPMVVLDSLKDWRFARNPHVIAAPNIRFFAGAPLRTSDGHNLGALCLIDDKPWDDFPPRSRLILKELAMVVMRELELWRDKVSSFPSLTSSLGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB01</accession>
    <name>K1VB01_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB01"/>
    <dbReference type="STRING" id="1220162.K1VB01"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_3_1"/>
    <dbReference type="InParanoid" id="K1VB01"/>
    <dbReference type="OMA" id="HDPAQKS"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="315" mass="34988" checksum="FE1EF8514AC46387" modified="2012-11-28" version="1">MSSSHSRYAIITGGSSGIGYEAARDLATANPDMQVAVLARTPPRALPANTAFYPVDLGDLASIQSFLDEWDHPVSALICCAGVSLRKPVLNEDGIDTTFAVNHVGHAALFFGLNERGRFTVDARIVFVSSSLHRRVRWSSAEEAAHERYQRGMTAYSTSKLANVLFANTLARKAAEHGSGWRVNTFDPGFVPTTNLFRGVPLLGRWFINYILPWFSWLLKLRGAVVSTPKRSGRVLALMAYDPQYDVNGKFFHVEEEKDSSEASHDRALQDDLWDWTARYLKVPKEISCLRMSSIYGGEPTATGGKPPWSLEDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC92</accession>
    <name>K1VC92_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC92"/>
    <dbReference type="FunCoup" id="K1VC92">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VC92"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047042_6_0_1"/>
    <dbReference type="InParanoid" id="K1VC92"/>
    <dbReference type="OMA" id="PHEPDKM"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="19856" checksum="DA67B212EBA7CB54" modified="2012-11-28" version="1">MALCSELGIDPSSDSVLFCLASDLGSKATGEWAKEPFVQGWLEIDPSLAKMKAALPGLRKKLNSNPAYFKKVYMHTFDLCKAPGARSLTLETGRLFKLPPGAASSTQTDEPPAFDGDDLEMWLEFQRERGKAVSKDTWSLFIDFLRTIDKQYKEYDEEAAWPSTIDDFVEYARAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCB3</accession>
    <name>K1VCB3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000390">
        <property type="protein sequence ID" value="EKC98450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VCB3"/>
    <dbReference type="eggNOG" id="ENOG502SERH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236852_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCB3"/>
    <dbReference type="OMA" id="QLDVWRM"/>
    <dbReference type="OrthoDB" id="2591260at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1865"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1651"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1755"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1804"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1868"/>
            <end position="1880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1888" mass="207004" checksum="A740EAC3233FB752" modified="2012-11-28" version="1">MTPSTRRSGVVVVDTPASSSKAMMTPTSGGRSKFDAVVLRASRTVAPPSTPSGRVTFSQHNKTKLFRINDVLGSDPPSAAGCSSPVAGSSSPCQRAKATPTRGILKMTNKHQIRLAKSVREGTWGNREPARLVVSGNKPRRMPKDTTILAQVCDSSDVQGAPPSSDDDPASDEPNIANPSDPMDDASDDEEEEEVECLHPTSLVGVILDGTEDLLTLEEAYNTLTMRLRETLYDMGPPTAAQDTAFNLVCHPILEEAPAMVRAMQRDLQRLMGKVPSAETDAVSSPFRPPSSSNNSPRKRLPSPDQTPRRGYTESEVRYRRESAGVGCAVLRFLACIFNSPRLFHGFSEVDLESLLDLVLVIPKSPTLPTPSPKRTYTLAMIVLSHLRLATSMVQRSQQKIAAAIEAGLVTIGTGSFPLKDPSPIRKEAFNAWANLLRMYPSTFFLSYPQLLPPCLRALASPIVALRKCAAATLAAVIYAKQRLAEEADQILGRGPIDAHERKTKRQAISKSEAWTSSFLKSSMRTYTAGEKRNEWMPIETTFRQTVGSADQVAWACTTWALLVTLLGQEYNACSLAPLIEHIMDRSMRPSTNPTRPTLAATAWQHAIYAYLMAGSSTSVSEEGRLIRSYNPFIGSAAQDSTARVKTISLPVQFALEQANGDGNVSFSYAPCAEFNGEVRGSWQRAEKSKKFAWMVTTGLTAPAVVYAYSVVALNHQDPSAKELSKISGMPSSDGAVAEMTPEERRLPNFDRLDRTFDLVLMPTLQQFFAIRGVDRLKNAGWEIFQAVTAAEGKAKALDRLLCERYLAGDVIGMDKVLPETIAQFEKERIAASEIPGWGRVWVAKRLGKLMSLFQEAFNGIRGISELSAVQWVTNAEGVVLLPMTLSNVWRNLMQGIASSTLPDGGPTPLFVCGLQVAAQQIVSVMQSDPAVYIPVCLLNEEGKSTLNTDAIRLGIAVHLVDVAVEVLGATALGSTRLDSSPLNADESQITEDFGTTTFVSIVLHQVLRQSDFSFPLDVKVNDLLQQLVGTLLRTGASSGTRLLGEVSNAMPWIFEAQEQTQLDVWRMLAQNWASTIDLSPSDSASTTNHTGALLVSLLSGPFRNRNADSIWYIERSTDIRAAWDELLRVTVLRFRAKRAGSNFGVLETLAAHIEDFISIDDENGPGTGARTKARMASETTLHCLAVATGWISFVQPEHYHSSHYSINENYVPTDWLTLLANCLDAAYECGTHPSEGVDEIVQQLIQLFRSLRPNNTVDVLEPLRPALEKWMTDASENATGILAASLDDLYVAIVSALARAIENGDIERSSATMNSYIDQYAPRLGRTESPEVPAAFQDFWKRTFQGVPGLDFSDDVAGFLHSLRDVDKTFITANGLSTSEESQTQEDTQESAFEPALPDVEDALAVEEPVPSASADEPNVIQTSADYDADVSQSQQSSSKKRRRSEIVPQSTPLAEKTERTEVPASTDVFGPKRKTRSRKNARKGKSRSVREVSSSDSVRSASPSSELLSTSPGPNPNDTVIAETEIEDNGNSDDRPFPPSSSSAQRPETFFGSASRWLRKVPSLGSLFAAGHDTSEAHNRSASAPNVLVAASPGESDHSPEPSPLHTKTHRRKKSRRSERVRIQEPEPEPEPQPEPEVSILSPELEIVELPPEKAAFPAPAEEPEPELEPTQVDTQQQDDVDAAPAITRSAARRKRQQEVESSNRPSKRRRRSERNTRSETPQSQASSKAEEEVDESSLTARERRRLRRARSQQEAQPEPELEPTQQQSEQSTSGKFDDAPGDVTPVPTRRVTRQRSQAAPSPSPEAPPSPDTPRRSETQTHVLGLVTETLRHTDAIRSLEMDDLVSFLAGLDELRAHATANLQARADEQRREREEQRRVRRSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDE9</accession>
    <name>K1VDE9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDE9"/>
    <dbReference type="FunCoup" id="K1VDE9">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VDE9"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059252_6_1_1"/>
    <dbReference type="InParanoid" id="K1VDE9"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="103"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="152" mass="17507" checksum="A138FB5B47294198" modified="2012-11-28" version="1">MSDKKDQITLVTSDEETFNVDKKVAERSNLIKQMIEGEFTASSVLVKVLEYCDHHQNDPLPPSDSNDADDARRKATEISEWDAKFIQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKTPEEIRKLFNIVNDFTPEEEEQIRKENEWAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDV1</accession>
    <name>K1VDV1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_08524</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="14"/>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDV1"/>
    <dbReference type="STRING" id="1220162.K1VDV1"/>
    <dbReference type="eggNOG" id="KOG4665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_0_2_1"/>
    <dbReference type="OMA" id="FFDQFMS"/>
    <dbReference type="OrthoDB" id="5976622at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.220:FF:000003">
        <property type="entry name" value="ATP synthase subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004482">
        <property type="entry name" value="PRK05815.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC97186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="255" mass="28039" checksum="13779998569D26E6" modified="2012-11-28" version="1">MTKFFITSPLEQFEVVPFISVNAPILGQFNISLTNLGFYCIVVVFLVLGLHFVANNSFKLIPSKWSVALESAYASVQGMVKDQIGYTNEIYTPFIYSLFFFIIIANLTGNVPYSYTVTTSVIVAIGLSVMIFIGVTTLGLSIHGVHFFSYFIPSGTPLALVPMLVLIELISYMARAVSLGVRLFRNMVAGHTLLKILSTFLYQLFNAGILVAALTLIPFAIFVALIGLELAVSVIQAYVFCVLTCSYIKDAIELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF93</accession>
    <name>K1VF93_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuole transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF93"/>
    <dbReference type="FunCoup" id="K1VF93">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VF93"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="InParanoid" id="K1VF93"/>
    <dbReference type="OMA" id="HFLVRST"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="772" mass="84296" checksum="897BDCD3D84A0BB4" modified="2012-11-28" version="1">MINRLGQRLKENFHETTRDFNLPIGGLGGGTASAAYFDVSEDKIFDISKLLESRAEAERLEGMKRIIAAMSKGRNMEALFAQVVKNVVASSVEIRKLVYIYLLRYAGTNSDLLLLSINTFQKDLSDPSPLIRSMSLRVLTSIRLTAGIVMLGLKKLVNDRNPWVRKAVAAGLSKVYDMDSSTRSELLPLLQTLLGSPSPLTLGATLTAFAEICPDRLDLLHPYYRHLCRLLVDADEWGQIVALDVLTRYARTQLEKPSTAGAVKPSSTTDSYEGLDGDLAMLLDHAKPLLQSRNAATLLATAIMYFHLAPAGHTAIGQELLVRPLLRLAGSSTDEIAALAWDVVAAMAEERPWLFAPYAAQLYVRGTDGLVAKRAKVRALVALTGPENAESLVREFRHYANLPEDSVSALAVSALGHCVRTQPSVAEVALRSLMRLLKSTRPALVAQSVVVLKGIVLAAAVPNPQKLVARLARQLDNITNPAARASVFWLVGQFASDPSADAVVGWEGVAPWVPDVLRKGVRGFTGEEAAAKLQVLSLAAKLLVLSPNAQLEKFAQYLFALARYDKDYDVRDRARFLAALLRGVRNTPKEEGADEEEEEVGGVVLRREQVRHVLLSTRSVDDDGPSKSDYRVGSMSRSAGHKLSDYAELPEWTDDPTDSSLRESDKTAPQFAALPPTSFSSDSMPPSLPPPMAAVRSRSSNAPSPAHSSPASASVPHTTKSKFRDLDDFLNSSESESEESYEEETEEEEEEEEEEGETEEETDEESSSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG00</accession>
    <name>K1VG00_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG00"/>
    <dbReference type="HOGENOM" id="CLU_861033_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG00"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="292" mass="32586" checksum="028DD022A530325C" modified="2012-11-28" version="1">MNKLRLVGSCMKNEVDRFQCLGCSATISFPDDMDDGGPTGVPVSANVHFRRPLELPPAPAMWLPHRDPLNWQECYAGKPQAAIQHAAQHRPVWININCDILLWDMISAAYGEGAVGELTSPLLQILETTSGVRMLHTQDMFLDSVERLGATLPAEASLELPSEIKRLHLRLWDDECSCRIRLGHSAETLRISLDRALEAEVKQSPLCCLSLDVFKPCVKHLSIQVDLLDDAVVYLQAIRGKPRHSQLSVSVRWISPHMRVLAEQPPALREQLTEMLGVPVSVTLADEAWPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGA7</accession>
    <name>K1VGA7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein UTP30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGA7"/>
    <dbReference type="FunCoup" id="K1VGA7">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGA7"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026457_4_0_1"/>
    <dbReference type="InParanoid" id="K1VGA7"/>
    <dbReference type="OMA" id="PQRAYKN"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000011">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38149" checksum="570FB8387C31EB0C" modified="2012-11-28" version="1">MAPSVNKTKAKAKAKAAQLPVDAAPAGQMVDSWKPAQAQKAVKALLAYANKQAEKAEETELLGRDEHVWLSVNTKTGSTRKKLMPIKIQLPSPPLPPPPATSVCLLVKDPQREYKDLIAKHDIKFIDRVVGVTKLKGKFKPFEPRRQLRNDHDLFLVDDRVLPLMPKLLGKMFFEAKKQPIPVNLQRKDLKQELGRAIQSTYFHPSTGTSQIATVGVSTPEQVIANLTAAVPAAVDLVGGWDNVLSIGIKTSKSILLPVWNAPLQGRFKDAEAAEAAEADEADEEMEEEKPVKTAAKAKTAAEKPIKEKSAKAAVTLGDKKKSSTIGSGAKKAKAAAVGTSKTGKTGKAKPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGH0</accession>
    <name>K1VGH0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000263">
        <property type="protein sequence ID" value="EKD03195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGH0"/>
    <dbReference type="HOGENOM" id="CLU_116417_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGH0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="146" mass="15308" checksum="73267DCE2E53679A" modified="2012-11-28" version="1">MAAQASAQQTRRPRKRRRRAASYSTSSSEDSDSSDESGDEAPPEKMDVDGASDSGSSSSSTSSDSSTSSDSSDSESDAKPSTSVKGKAKAHPESDSDDSDSDSSDSSDDSDDESDRAVKASKPKRTVQRQPTLSPSTINSIDRHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGS3</accession>
    <name>K1VGS3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGS3"/>
    <dbReference type="HOGENOM" id="CLU_1230675_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGS3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="225" mass="25764" checksum="7232D0228F4E3D44" modified="2012-11-28" version="1">MNQEPDTRDVPPDHATTFEHIKEQLLIVWQAVLYLLEALFFLFLWTPVPNRIICYLFKCVPPVKDAVPGFQVHSASFSEHVPSNYTPGLIFVAQCAPRPHEYHSLPLFGDMSYAPVPRQTGLGDRPPSPPSRWGRLQDRFAEFKRHLDQRPEQAFVLVFVLVFVLGTGSFVLYMITGDFDDTGGTLDNDTWAEEARRFEAYLKPIMDRLDNITARLDRIESKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGT1</accession>
    <name>K1VGT1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGT1"/>
    <dbReference type="STRING" id="1220162.K1VGT1"/>
    <dbReference type="eggNOG" id="KOG0132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396384_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGT1"/>
    <dbReference type="OMA" id="EAWQNST"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="735" mass="77999" checksum="BA468F20363EFC5D" modified="2012-11-28" version="1">MVDLKTFDDLLDRTVRAPRLSGTKVGELRDMAKSLAAQHSDDIVDILTRTNASLQPASTSRISSLYVFDAIARAAKSDAALLGKMEAAVGGFVDSIIDNGKGGVWSEGRDKTRKIVDIWRKSQTFSDSCIADLQGKIAGGEDRRPNGKIPFLSPHHPSPFTSAVRAHDGSDAVPRRTDLLRPVVSSHSLNRACITLSTTPLNVGLLAAGLDGCGKKEGRIWSHKQAHGRLIDSTLEGLGCTGARVLRRGLSRETSAQSRDTGHPATEAEPREPWSHEVSSHTSTFHSPSTRVAQMLSSPAGSRSPPPAPGQLPPEIMAMLGVKSKADEKAETASAIDAVLANVRGTSTATPPPGSAPAPAPVPSFDPAQLAALANIAAITSTPTPPPAAPPAQPYPQSQGQGGYRRGRSRSPERRDGDRSDRDRDRGRWRDGDDRDRRGYAREDSRDRYYDRRDSRDYRDDRRDSRDMRDGYRDDRRDSRDDRRDSRDDRRDSRDSRDRRDGGRDGRDGGRTMDRAPPGAGPGASRLPPKPAGLPPNPTLPSRPDGLPSRPADSPPTRRRDWSQDPHPHSHSSHSHSGYDRRDRSQSHGDRGSHDRASHDRGGSYGGGGSGGAQGGNGGSGGATLQTFDLTSFNPATPESWSALAQAWQNTTGRQPNQFELMQFLATGAQPDSSTNAGGSGSGGEGGEGPGGGMGGMFGMPGMMGMGGMGMGGMGGGMGGMGGGMGGMGGMNGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHH7</accession>
    <name>K1VHH7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHH7"/>
    <dbReference type="STRING" id="1220162.K1VHH7"/>
    <dbReference type="eggNOG" id="ENOG502TN2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099094_1_0_1"/>
    <dbReference type="InParanoid" id="K1VHH7"/>
    <dbReference type="OMA" id="LWWVAQS"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853794" evidence="2">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="193" mass="19734" checksum="0505FEB20012CE18" modified="2012-11-28" version="1">MLFKALAALTVAASALAQASQNLTITAPSPTWWWIEESENKLAWAAGNPSDSTTVYINHKDNNVIAGGTLAIKAITNVYDYSTLLTLPPGVKPAKGYFITIVDSIYQGQRVYGQSQEFEVKPKGSAYPDQNQDLSGRPQTSASESATGSAGASASKSGASSAPSASASSGAQQNMAATALAAGAAALAYVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHX1</accession>
    <name>K1VHX1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="7">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Myo-inositol 1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_06953</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHX1"/>
    <dbReference type="STRING" id="1220162.K1VHX1"/>
    <dbReference type="eggNOG" id="KOG0693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_2_0_1"/>
    <dbReference type="InParanoid" id="K1VHX1"/>
    <dbReference type="OMA" id="VYVPMKE"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="19">
        <location>
            <begin position="342"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKC98721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="556" mass="61166" checksum="29311FC73CB4F516" modified="2012-11-28" version="1">MSPTALNNSNGHHDSFTLPPNAERKVHPSAARAPADLIKVESDSTEYTPEGIKSKFTDRGAEVVKDKDGKYTVKKTENTFEFFTKTKVGRVGLMLVGIGGNNGTTVVATNLANKHGISWHTKDGEQQPNYIGSLVRASTVQLGVDPETGKSIYVPISDMLPMVHPNDFVITGWDISSMPLDQAMARGKVLEYDLQRQLAPYMKDMKPLPSIYYPDFIAANQSDRADNLIPGNDKQAHLEQIRKDIREFKQNENLDNVIVLWTANTERYADIIPGVNDTAENLLNAIKSSHEEVSPSTIFAVASMLEGAPFINGSPQNTFVPGAIELAEQKKAFIGGDDFKSGQTKVKSVVAEFLVNAGIKPLSISSYNHLGNNDGKNLSSARQFRSKEISKSSVVDDMVAANPVLYDHTATKEKPKGEHPDHIVVIKYVPAVGDSKRAIDEYYSELLMGGRNVMNIFNECEDSLLATPLIFDLAILADLLTRVSYREVPKNGEAGEFQPLYSVLSLLSYMLKAPLVKPGTDVVNSLNRQRNGLEQFLKACLGLENNGDLLLNTRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI43</accession>
    <name>K1VI43_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI43"/>
    <dbReference type="HOGENOM" id="CLU_685471_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI43"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="402" mass="44401" checksum="C2613CB0D6249098" modified="2012-11-28" version="1">MVQAATGTADQYDERLPFNTALDPSILGRTPGSPVHLVGGGVGDGDRSRDGDSHTRAAGLHRGHQWVDVRCGPNSPLMDYYVSLLEHAVQLVDGEQPPKPGSDGEEVGPAVPGLVGAGPQVNVEKLKGPSRPTRNKRKIPPVAKLGNLQLELASSLIPLLNHRGVLCTQRQGFEHTFVDVEEFLAAEEEAFYLKNPRDPLLRGYDIRYQETDQPLDASASLKWQRNARDVARKGFVRENLEVALDALSDKNARRPSNNRGAIMNPLPVHIYREHDYSDFTSTKNLSLRAETLRLKATPAILALVNTHLEAEHNDAFQSPDLSDDLADAEAAAVAADAATLEDRNTRHQEFGIWAVPESEVYAMRNRVRMGRDGLIRRRRDRAITDDKDAIKRARYDGIALDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ13</accession>
    <name>K1VJ13_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ13"/>
    <dbReference type="eggNOG" id="ENOG502QTPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276612_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ13"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="92"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="949"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1150" mass="123137" checksum="0B9E84B85EF9A51A" modified="2012-11-28" version="1">MPSSSPSSNSAPGPSEPLKRRRITRACDRCHRGGVKPVPKGGAKPSSQSGHSASGHPTPHGPGSQNGALGGEAREWEYQAVGTPDLVDMLASTFYRVVYPILPYFHWPTFSARVRARHYERDRAFFAFVMAVCAITSARMRDGVGTPLPPDAPPSEAFFDASLSAFPADLTVATDFDYKRAKAILAILSLQYGQVRQLSVHLGDYLTMCAADGFHNENRWPPNLPVTEIEERRRVFWGVYSIDVYAACTWGGIVRHRETQANVLYPAEVWDDSEITETGIAKPAGVSFLRGWNFTNDLYRILEHALGLLRQRKLEPTDSQVNRRLFSLTRLNSSFPSSKEVLDTIQEDYNQLPMEFKGAQAMTGNVYEDRFGFQAADIIVTMQTVKMVMTGLEDASVEKRCAIAGELLDALSTVPTAYIQAISSPILHHLAGVGHLLGSVIQTPLSHWTYLQVRNVLLAMADLLSSLESTMSFTPGIAEKLRDHVKRIDQYMTAAAVDRSRRAQVWHTALPPSAWQYPNTPGVGSGGDSSVRTTEEPQKQEEQIIPGNLFDLPLDLLTTDWPLDMRDAFDFLGPAPAGASGQAREVDYIEANETEELELPEGRSLEVEYIEADETGEPEQPVGMSLERIETVTPPAVADAPVGAVSSITTTPLQTTSAEATGDILGILLPPINVTPPQPPTITAPVTPAQASTRAANTPRSSGKSVRFADTPAAGEWHRPSFVVPDLPMPPPPAVTPPPVPDLLLDRASWRPPLALGPWPGLSLLADAALPVVLPAAPHGADPLLPDSVAAAAQSQATAALAFVSQLGATEVSAAQAPAQPLQFLEPPMVTENTAVEGLALQSVQLPPPQAMATGNLAVEDLAPQLVQLPAPQAMATEDLAVEVPEPQPVQFPAPQAMEASGPAAPAPASLYPPSRAPEAQIVHLPAPLVDDAPVLQDLPFQTPPAPEPAAEAPSTHTLPSLPVTPSPAPPAQASVLMSQTQALSAEITPEHSSVHAPSSSAVHTPARVRRKEQTPLPLRPPSLLDSASHVSNSPLAHLSVAALHLHAALDKPGLLIPRAAQQTSSQAQSSAEHGDQAARPEPEPKSKQLKFWQTNSNQSSQIAEVPQTSPQAPQPGQPPQPQPMPQPHHPPTVHLPRPHHPPAPPSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJE5</accession>
    <name>K1VJE5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJE5"/>
    <dbReference type="HOGENOM" id="CLU_1008974_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJE5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="30688" checksum="D0310A9D8A96BA86" modified="2012-11-28" version="1">MPSQAPSPTPEGTFWSRPLGIWAERHHVGLLTYCPYLSLYWSSKLFWHFRQSEITDFVKWLEANGRTVTVPDCPKGYSVYAADSALGCKADIVIVVDAATTLVWILLGAGYTGLVLVLLRKARDAGITLSFPWAPRYIPHGVDGRPIDRYAGARPPKPPGPPAERPVHLPIPWFLEVGLGIMTTLSVVVFFDILWTLLIQTWAFESPDTPVCQRGGSWFPVYVYEFGGGSQRCDRTWRIVMLAVLYTFNAAVAAAANGLSLVLLQREILYDGFGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJH5</accession>
    <name>K1VJH5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJH5"/>
    <dbReference type="STRING" id="1220162.K1VJH5"/>
    <dbReference type="eggNOG" id="ENOG502SMFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554538_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJH5"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="492" mass="54343" checksum="00CEC4B0792FE103" modified="2012-11-28" version="1">MLYPSRPVLRVLVPLVLLGSILGILSLRAPLRQRTPYAEEWAEEQKASEGADPEGRYVLSHAAAVHIELPPGLRVEPLTGIPEPARGGGGRHVPVVPNAAGDGGAHIGVHRIGRVWLRGAVRSTKGCFYRKVCSKEEEAVYRVSMTTKDGNVIATGGGVATSYTHAELMNVTARCLRVQGEIFDHKYLKTLHSLSLAPVLIEHPTLRYFTFARSVLSLVNDMMPTLAKAYPKYNLDLHATAKGVQKMDTFKHILVLHLEHGERWLERCTQAGLANEPFLGFNRLPSHPGNENMPPPPETVEATRLGVYVAKCRPDYTAIVHRARRMRKNHPLLRTIYLVPNPAGESSWVEDVRRWLLSDAWNEVYAGAGDFGIDGIERAGVDMEIARRAGVFVGNGLPIALYKRAGRAEHRQRDQGRELPRPRGRSGSPVTGTRETHRMLVFAYLIASTVTWPSICIDCCGPALDSRTPDLPPDDLSSRHDESGGMQIFAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKE9</accession>
    <name>K1VKE9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKE9"/>
    <dbReference type="HOGENOM" id="CLU_1262313_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKE9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852238" evidence="2">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="219" mass="22089" checksum="D3D7677460690229" modified="2012-11-28" version="1">MLKSAIFALTAAAAANAAAVNTAAGGIQLHELVLRTVPEASAAGNNAAGAGLGGFPTLAQPGCDNQCKPWLDMINADPCFTAETCPNSELMQTGKRICENLDSIAACGYCNVAADDRNAVSDSIKKTFDACQNAYGVPAKLPAAPEVKEVASSTQSVKEAETSKAAAPKESQTSKAAEAPKASEPAKAADASKQEKSGAVARTASIAAVAVGFAMALMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL12</accession>
    <name>K1VL12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL12"/>
    <dbReference type="FunCoup" id="K1VL12">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VL12"/>
    <dbReference type="eggNOG" id="KOG2581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019858_1_2_1"/>
    <dbReference type="InParanoid" id="K1VL12"/>
    <dbReference type="OMA" id="AKVYFYF"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="276"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="523" mass="59270" checksum="579BBA44997D72AD" modified="2012-11-28" version="1">MTTEKKDPKLDPRDKKDGEKTADEDKKDEVVEEKPEPLSVEDEILNNLQLIGRAVSTIEPRFTTRVLRTLTTLRKRLTKRQLADAITRAFPKGSKVGQQLIASDLFQGLPDTAPEAEAESMDDGKDSKEGKKDAVAKKYQPPVDQTGELIPEGVMYLRLLIILAGIDAGLIENAGAFALETTEQIQAANRRTMDQIAAKVYFYLARCYELEGRLAELRPTLLAVRQTAKLRKDENLEITVINLLLRSYLASNLYDQADKLLSKIEMPTSSNTAQTARWLFYTARLRAVQLNYAGAADLLLTAIRRAPKDEVAPGFVQILHKFYIVTEMLTGRIPDRAMFRRPVLQAALAPYFQIVQAVRVGDVAAFQRAFTTHEQAFLADSTHFLILRLRHFVIRTALRTITLAYSRISLRDVCLKLGLDSEEDTEYIVAKAIKDRVIDATIDHKGGYMQSKSKKNIYETSEPQEEIKQRVKYVLDMHREALQGMRFSGNVHRKELETAADARERDREIAQLIQETEDDLDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLU4</accession>
    <name>K1VLU4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_04052</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Also forms a small population of homotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLU4"/>
    <dbReference type="FunCoup" id="K1VLU4">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLU4"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="InParanoid" id="K1VLU4"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="210"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="238"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD01681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="537" mass="59026" checksum="E8D15994B38C9D4B" modified="2012-11-28" version="1">MASAEIHDLYDSILILDFGSQYSHLITRRCRELGVYCEMLPCTQKMADLSWKPKGIILSGSPYSVYAEDAPHVDPAVFEAGVPVMGICYGLQEMALTHGGKVEAHTHREYGFARITVEKTGNAGADALFAGIDIPEEGMTVWMSHGDQVASLPPHFLTVAHTPTSPWTAIAHESKPFYGVQFHPEVTHSKQGKLVIGSFVNNICGVKPGWSMESFIPKEIARIREICGDKGQVIGAVSGGVDSTVAAKIMHEAIGDRFHAIMVDNGVLRKDEAKKVKKMLTDDLGVNLTVVDASDLFLGRLKGVEDPEKKRKIIGNTFIEVFEEEAAKIEKACAEDKSKGPIEWLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRALGRLLNIPAHLVGRHPFPGPGLAIRILGEVTREQVQILQHADDIYIEEIRAAGLYDQISQAFAALLPVRAVGVQGDARTYDQVIALRAVSTEDFMTADWFEFPAGVLKKISSRITNEVRGINRVTYDITSKPPGTVEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLV6</accession>
    <name>K1VLV6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLV6"/>
    <dbReference type="HOGENOM" id="CLU_1355516_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLV6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="202" mass="22426" checksum="7527E4AFFFF9F367" modified="2012-11-28" version="1">MQSSVGSDYVASGLMRSSLGEARNVGFVEEDTLHTPILRYELGNAKLLQMLTPIKTGTDRIGVWSQHQVDQSQPCSHEATVVAARSLEWSHRATDAVGRVTCPPAAARNDFWVARNGIDNFETGNMFTTAAQDTSVCLMSLGDTEAQTRSNLRLAASSMSTPSHTRFHEDTYMRPATPTPQLWRNHEAYWTPHSCTWQGTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLW3</accession>
    <name>K1VLW3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLW3"/>
    <dbReference type="STRING" id="1220162.K1VLW3"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_2_1"/>
    <dbReference type="InParanoid" id="K1VLW3"/>
    <dbReference type="OMA" id="KWILVEA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="41"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="11">
        <location>
            <begin position="419"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="487" mass="54377" checksum="B5E0B02B07935D21" modified="2012-11-28" version="1">MLTIRRAVLRTPTLASTTALRAATPLATRSFSSSTVLDKEKLVILGSGWAGYNTARKVDKDHYDVTVVSPNNYFSFTPFLASTCVGTLEFRAATEAVRKLKHVNYAQGWADKIDLSNKVVHVAPSLPPYEDPHQTSPHDKNYTSGAEILPEYTPSDAYHVPYDKLIIATGSRSQSFGTPGVMENANFLKDVREARAIRHRLLQCLEMAYEPSLSEQERRDILKFCIVGGGPTGVEFAAELHDFVHEDVRKRFPDIADKIEIRLFDVAPGILMSFDVALREYAEKKYARDGIKIMPNSKISKVDRHALYLDSGERYPFGLLVWSTGVQANEFVNSLQTLQKDDKTHSITVNEHLQVIDKNSGTVVPNVWAIGDNCTPTTGRLPATAQVAAQMATYMSKSLNKLAQGTPVTDLAAFKWKNRGSMVFIGDEKAMVDRSGSSTFRGRVAGFMAWIMWRSYYMSLALSPRNKILVPVYWALAWCFGRDIVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VME6</accession>
    <name>K1VME6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VME6"/>
    <dbReference type="STRING" id="1220162.K1VME6"/>
    <dbReference type="HOGENOM" id="CLU_513073_0_0_1"/>
    <dbReference type="InParanoid" id="K1VME6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="531" mass="57542" checksum="4AA3431954F61383" modified="2012-11-28" version="1">MADKRPQSHATSLTSLLFGRRTSNKSSSSKSSLALTSNQVDARKATPSSSVTTSDQFDEDAARLTSPRGGTVPLPGISGPAASGSSAPFQIDQALASMETMEKKSTELVDLVKSTSVHLANVLLDHHGSSPRSLEEMGLDAEGARKLYGYAIDFCSPNSEYALRTAAMRLLAVLLGAMPPREAALDPAPAYLPPTVTKVTLYRLITAPSANSPGSGPTHTNQIFVEVGALKALTRDGQYMDGMDGIAGWLTRTLIDLQPDWVAWCAEPDDSVLDDSRDSPFGPIKSASPATAACEIIALLSSIIQNRLPLFAPNDLSAVVRPILKYLWAGITATISASSPEGATSPQGPSSTHSSVHHSKHGSPISAVRRGAETRRTSSLTVGRVEPFPAKPSKSPSRSPIVRPPKWESPFKAMCALVHMLFETTTINDDLFNRVFELLCFAFGQDDTMLGADLLLVAQELVQTMLERLTQRKLASTSTLCSEHRLHKLLRDQQQIRAQHRVVLSERKTQQLKHAVEQVIVYRRRLEQHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMJ3</accession>
    <name>K1VMJ3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMJ3"/>
    <dbReference type="STRING" id="1220162.K1VMJ3"/>
    <dbReference type="eggNOG" id="KOG1624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824358_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMJ3"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="36793" checksum="C19C100E9FAE796C" modified="2012-11-28" version="1">MQAARCLQALRRPILTPLVGSSRVAARAFATEVPPAPESSEKQPAAHAEDIAAANDLTAHLPANVSFVDLGSRPTPRQIVASRGVRLHEVPTDFYSPIEHPVSSLTSANPTEGSGETLPLPSHVFNLPLRRDILHRNVVWYLANLRKGNQSTKNRSTVAYSGRKLRQQKGSGKARVGDASSGTRRGGAPIFELKPRDWSQDLPRKVRALGLRTALSAKLNDGFLRVVEDVAEGNWPGTYEARFGPKDGLNILFVHSPMREAEGVANLWRVTRNVPGIEVLSTDDLLVYDVLKYSWVVIERGAIEDLAGPGWFDAVNEAYGLEAPEEVQSIETTTTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMR2</accession>
    <name>K1VMR2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMR2"/>
    <dbReference type="HOGENOM" id="CLU_601567_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMR2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="455" mass="48605" checksum="67F9B8E706B0C659" modified="2012-11-28" version="1">MTVSVRALRNITDALGFTFSAATFATALSAVCIAGSWERIISGYAAQLICGTVFGAVAIAYYISSLSVTAAKPQSRFTSLFTSVLVRGFLFVFGAAMAGYQSTIFTGVRECRRYRRLNIDGNPGPAANCNLPLAAGILAWITVGVIAISVVVEIAVITSRYGNTKRTWRSSIAALEHGTEPSAAHSAAGSGIAHPPLLVRARNSDATLRLEDLPDPNRAQTQKGSAKRGSRASTPCSQCRWEAQPAVHLSGSILLNPSLILPLFPLNMTPPVTISARTLRLCTDTLGFLLGAATFATALAALMIAAYWERIMSRYADQLICGIVFGAVAFLYFVSSKPSSRFTSLLSSFVARELLVALGAALAGYQSELFHGVRVCNRYMSSNPSFTPAINCRMPFVAGILAWVTVGAIALGVGLEIAVVTSRYPNTKRIWRSSLAELEGSTEAYRNTAPRVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNC0</accession>
    <name>K1VNC0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNC0"/>
    <dbReference type="STRING" id="1220162.K1VNC0"/>
    <dbReference type="eggNOG" id="ENOG502SCSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049925_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNC0"/>
    <dbReference type="OMA" id="ARIKCEW"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28610" checksum="0A2F9D231ADC26BF" modified="2012-11-28" version="1">MITDNARYPDPKRSIPPRVRLDGERKHKGWDLDALAIEGNEGGRHLAWLPSLPANAPIDLIRKVYERDGVVHLRGLLPRKEVLDVRRRFFEYVQHTGVLKEGTLPEEGIYSGIYGELDGEDPLAEYRTGANYERFVRDFVAHPLIADMAARIKCEWKQPWAFRQQVLRTNLPHSRRTATRVHYDQMYLRGMEPDALTAWIPIGDISPVGGGLMYLEDSVPLGTEIENLFKKLNANLPEEAQLDAFNENVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNH7</accession>
    <name>K1VNH7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNH7"/>
    <dbReference type="HOGENOM" id="CLU_1103426_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNH7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="27491" checksum="353B60865BC03F5D" modified="2012-11-28" version="1">MNPDHESVVAATYQYVVVAVVACGVFAAGVTTIMLRRHRRQQLLAAARGGGDGRVVFGDDGYLYDMPGAPRVNTAGRTRRKKLGPTPKIWDAEVGGEYAEEADEEIGWEEQKNMGVGLQVGLAASAASSRATRSLQPVSVAVPAHEAETEDQPYVDVAVLIAMPDPSLSYSTDEEYPTFRPPKVLNDDEYEFPPMAVSSLRVPVSTAWADLDALRPPPKERRKKKPAPPQPPRQSAFRRFLMSASTSAARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNQ2</accession>
    <name>K1VNQ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GSNO reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_03466</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000295">
        <property type="protein sequence ID" value="EKD02246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNQ2"/>
    <dbReference type="FunCoup" id="K1VNQ2">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNQ2"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="InParanoid" id="K1VNQ2"/>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="191"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD02246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="371" mass="39757" checksum="76AA87836FEE43CA" modified="2012-11-28" version="1">MSSTEGKTITCKAAVAWEAGKPLSIETVEVAPPRDGEVRIKILYDDYTLSGKDPEGQFPVILGHEGGGIVESVGPNVDNVKVGDHVVPLYTAECRECKFCKSGKTNLCGAVRATQGKGVMPDGTSRFTCKGKQLYHFYTVVSKYSVVAVNEKAPLDKACLLGCGITTGYGAATKTPDIENSTVAVFGIGCVGLALIQGAKAKNASRIIAIDVNDKKEEWAKKFADFINPTKVPGGKSIVDYLVEITDGGLDFTFDATGNVQVMRQALECCHKGWGVCNVIGVAPAGAEISTRPFQLVTGRVWKGSAFGGVKGRTELPGLVDDYLNGKLWVDQFVTHNQPLEEINKAFDDMHAGDCIRCVVNMQQDGLIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP38</accession>
    <name>K1VP38_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP38"/>
    <dbReference type="STRING" id="1220162.K1VP38"/>
    <dbReference type="eggNOG" id="KOG3039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053742_1_0_1"/>
    <dbReference type="InParanoid" id="K1VP38"/>
    <dbReference type="OMA" id="PCVTKFM"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="203"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="295" mass="31971" checksum="CA204E0492FECB3E" modified="2012-11-28" version="1">MKPMDHCNLCLSQVTDAVACPEAHVFCRECCYADLLAQKAGIERQKAELDAWEREDERKRFEAREKARERVRANFERGMGLGGRVRIGAPKSDGVNGAEKDGEKDLEAEVERLAREAEDAALAAIEAEESDGRKAKIAAFWLPDNTPEAPLGPLKAVKLQTLCHVGQAHPISRKSLLPVVFSYPSSKAPSSSSGSSSESKPGCPSCLREVNNATGAMLLTSSKVEKAEEKADGEEPKKKKKKKDAKEKREAICGHVICNACCERAQKGGNTCPVCEASIERAIPLGKEDKAVPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPP3</accession>
    <name>K1VPP3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">A1Q2_04284</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPP3"/>
    <dbReference type="FunCoup" id="K1VPP3">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPP3"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="InParanoid" id="K1VPP3"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EKD01442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="367" mass="42405" checksum="272F9AFE31804B88" modified="2012-11-28" version="1">MHQARIFANADVSKRNTRKQCWITYNGNVYDVTEFLEDHPGGDDLILNVAGGDVGTIMADPTSHAHSTSAYEMLEEFKIGELGGDEKIVSEDWVPDVDFHPDETNVKSDYDKNKFLDLSRPLLMQVWGAPWSKEYYLSQVHNPRHLKESARLFGPDFLEMFTRTKWWVVPMVWGPITAFLFYLSALQFTNSAITAKDLLKLPLQMPLPTPSAMGLAKTIPCFLLGNVIWTLLEYGMHRFLFHIDDHLPDQNWAIVLHFLLHGIHHYLPMDRLRLVMPPLLFFVLETPFTKLAHLIFPKAIANGIIAGAFAFYILYDCCHYALHHTRLPQYLAELKRYHLAHHYKNYELGFGVTSKIWDVVFHTELFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ12</accession>
    <name>K1VQ12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ12"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="InParanoid" id="K1VQ12"/>
    <dbReference type="OMA" id="LHLCHKR"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="431" mass="47850" checksum="FBFEF89AF3E20FC4" modified="2012-11-28" version="1">MDEDEVKEALLAPSEHSDCSTHSLHQERPCRPPRYRHTLLPLALKAMYVLAFLSALPLLARGLSSFNERNNSVSHGIDNDSQVEHGHHGSHGGHHGKKGKKDKYGGKTLAPSNVTVITGLFRQDDPDLDPEGYDMLKDSFGLLDKSPDRWKKFTRHIKKLNEEADDQTTYKVVFIARHGEGYHNVAESVYGTPAWNCYWSLQYTDGNMTWGPDPLLTPLGESQAKSANQGWKEQLKDGVPLPQTFYSSPMRRSASTLEITWRDIVLDKGVRPVEMWRETIGLHTCDERSNKSLIAKTYPGFDFEPSFTEHDPLWDPEFEETQTQLAVRARLALNEIFATDPSTFVSITAHSGVINAFFLAIGHRKFQVQTGGFVPVVAVSHPTATFSSITRGQSATAPACTEDPTAKVMAPASVTVPPTWNAQATPTSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ79</accession>
    <name>K1VQ79_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="1">FBP aldolase</shortName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ79"/>
    <dbReference type="STRING" id="1220162.K1VQ79"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_4_1_1"/>
    <dbReference type="InParanoid" id="K1VQ79"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="518" mass="56377" checksum="E4D8060E44A713F3" modified="2012-11-28" version="1">MRSTRPYTGRDRSVTKRSKRSGPGIRQLRGRAVGKVRAGDIGGGGEGEWARAVLNRQMPGGQRASYATSLNILLLSPSSESTHIHVWIYLITCTHLLSGGYDSFDSPPVLPPRTPSLDPIPPSSEKKPRAMSGLTSNRTLQILRKAQEGGYAVNAQVVYDAGQARAYVDACERKRSPGILMLFPISVQQQGGAFLRYCLDIAHNASVPISVHLDHATSAEQLELVLGLADKGTKFDSIMVDASHADTDEENIAIARPWIERCNRLGIATEVELGRLEGGEAGLREITGAMLTDPAKAEEFVKNDYREGILDALVSDDAVKGDVLLSDSEYRSPRTSLSDSPLRDCVSESHASENHVSENRYLRNSHTDSKNAFPENASPETPIAENTSAENGLTSRTGADILAPSIGNLHGSYKFLPGGPQFDWSILEDLHARFGSSPTGPYLCMHGTDELSDEFFRRIVKCGVSKINVNSWLREPYVSTLSKALQTKTMPEAIDDAHEAMVKEAERFCDLLGSTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQA0</accession>
    <name>K1VQA0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_06858</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQA0"/>
    <dbReference type="FunCoup" id="K1VQA0">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQA0"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_1_1"/>
    <dbReference type="InParanoid" id="K1VQA0"/>
    <dbReference type="OMA" id="KNVTPRL"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="341"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="411"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="481"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="802"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="915"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC98887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="941" mass="105683" checksum="327AB248F9DDE6B5" modified="2012-11-28" version="1">MSSYASQHPLTRRGGRGTPDESTPPPYNPPSSSSGPRPESDADAKLRNKDDGPVSTSTSFSMRRRGDRAGGKLGLRRREWILLGAVTIVACFVRLWNLGWPTSVVYFMDVHPPLAKLLVTLSAFLGRFDGKFDFKDIGKDYLEPNVPYIIMRAFPAILGLALVPLTFLTLISLRLSLASAILGALLVTFENALITQSRLILLDSYLVFFTALTIFFWVRFSNDDSEGRAFTPSWWRNLALTGGALGAVASCKWVGLFTIATVGLGTLRQLWLLLGNLKVTPRMWIKHFAARAMCLIVIPVFIYMFTFWIHFWILDQSGDGDGFMSSEFQHTLDGHHMMDTYADVGMGSLVTIRHVNTQGGYLHSHNSAYPGGSKQQQITLYPHKDENNVWRLVNASAPDGAVSYPWDDLPFESIITGTKLRLEHVQTEKRLHSHDVRPPVSEVDFQNEVSGYGFPGFAGDANDDFVLEIVPETRGKDKLAKHQLRTLRSVFRLRHAMTGCYLFSHKVKLPDWGFEQQEVTCNKNPTWDNSLWYVETSTHKQLPEDAERVNYEKPGFVKKFWELQGVMWRTNAGLTERHAYDSRPQHWPWLRRGINFWVKDHRQVYLMGNPVIWWSSSLAVLTYVAVRGLLILRAQRGYRDLYLPKIAYYDEVCAFLLMGWALHYAPFFLMQRQLFLHHYLPALWFAILLFCTVFDYATSRIRPRARLQIAVAIIIVAIWSYNYFSPLAYANPWTRPKCEQAKWLKSWDFSCADFHGSMHEYYAQSAVVEPEKHVYVNAEAATTTLVEEVPEPIANVFDKGDDAAQEEKTQGLAGPQKEQPPMQDTTGGNLVGKVAADDAEIPADDRAPVGVDAGAVGVTAAEQLDGWRGGANEDNADHTVVAESQAVPAEPVKVEQAAPVAMELDDEAEQLAHEAEEAAENAVPAAGKLPPGVEEIDVQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQC7</accession>
    <name>K1VQC7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Leukotriene-A(4) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQC7"/>
    <dbReference type="FunCoup" id="K1VQC7">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQC7"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_2_1"/>
    <dbReference type="InParanoid" id="K1VQC7"/>
    <dbReference type="OMA" id="FPGNHHP"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="10">
        <location>
            <begin position="476"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="307"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="568"/>
            <end position="570"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="609" mass="70032" checksum="1CC27FDE2294A31A" modified="2012-11-28" version="1">MLALRKRGRGRKSRVPVEVWPRWLSQMTACDRMVSAKIRCEVSTQRAIPAFLPDRPCFRLPQNYRSRQYHSQAPKNTLRTMASSAAPVSQDRDLSTLSNYQDIRTDNIDLDWSIDWDKKTIGGTATLKLEAIKDVDEVVLDTSYLDIKDVTVDGKKALDEHIEAMGQALHVKLPSTLKKGQTKSGKYPYLYSQSQADTPAIKATYSSRVTSVLPVLMSALRQSPPSDEEPQYGKKIEYVYKQVTYKAFPDMEGRNWKTGVWTEPQTMKAAYWEFEEDTAKQVATAEDLTSAYRFGVYDFLILPNSFPYGGMENCCLTFATPTLLAGDRSLVDVIAHEISHIHGEPARMLSFTIGRVGLKESLKGYEDTPRFQKLLPDFKNHEDRDQVPYEKGSNFLLHLERTVGGLDHFIPYMKDYVKTFTNKSITTEQWHKHLFDWFGKQENGEEYLKKLDKVNWDEWIHGTGLDLCIDMQYDDSLSKPPTQLAERWAAAAKKGDLSQFKPEDVKDFDSTQKCVMLDHLYELGPKYQPEVATKLDEIYGFNQTQNAEIKLRFYKIALKSDWVITKGRMKFCRPIFKLLNEQNPELAKKVFKEHAEFYVSDKFAATRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQF5</accession>
    <name>K1VQF5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_04178</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQF5"/>
    <dbReference type="STRING" id="1220162.K1VQF5"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1327215_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQF5"/>
    <dbReference type="OMA" id="RHEYASS"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD01617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="23408" checksum="404C75E31C0B4C31" modified="2012-11-28" version="1">MATRQSLFPAPRQSLHPSAHARQSYAPNALRQSLQVPSSDFLSSLEDCVASTEACVARLDATNKAFEPGIKDLPRIKRIFDHNVWFLVLPEPTVTKRRHEYASSLRPQIDSLVERAETLVSSESSQLLHARARLQQLESALRPALPAAPRYANTFLSSEEEKVGCKLENNLEGRKDLTMAQRRKIGMLRNKRERLERERAKLLAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQJ8</accession>
    <name>K1VQJ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQJ8"/>
    <dbReference type="eggNOG" id="ENOG502RB7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912214_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQJ8"/>
    <dbReference type="OMA" id="WIWERED"/>
    <dbReference type="OrthoDB" id="2565062at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="33830" checksum="7AA78EAA1D194A4F" modified="2012-11-28" version="1">MSVSDLVLLKVLELYNITHPLRSTIQLRTFRASFPPPPTPTQDTALGGGTFAAPQTSAGPTRVLTTITYSQHLPPVREVPMPLGARDDVTYLFLEDRGVTAAQPAGPGPGEVRDGVAPDPPAQPEKQERKHMMLAVRPATSVMPTLQQLLSPFVLGLSKSARVQASTTAQAAAPTPLSGTPFVLTSLAFPPAMGTTMPPVALSLHVLPGGTAQTIFLEAEWDAPLSGEGAVSGGRRESEAGRKDSAYPVRVDTGFLETDSVAVGVLKEFLDGCVPEAGERRYWIWEREDPEGWVGIEKNKRTAFLLARALRESGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQQ2</accession>
    <name>K1VQQ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQQ2"/>
    <dbReference type="FunCoup" id="K1VQQ2">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQQ2"/>
    <dbReference type="MEROPS" id="M01.006"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_2_1"/>
    <dbReference type="InParanoid" id="K1VQQ2"/>
    <dbReference type="OMA" id="FIPCVDH"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="5">
        <location>
            <begin position="100"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="3">
        <location>
            <begin position="480"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="3">
        <location>
            <begin position="591"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="4">
        <location>
            <begin position="804"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1143" mass="126500" checksum="2E314012291DB3A7" modified="2012-11-28" version="1">MLATSRLWQTQSRHLLRHPSPLPVRANLSTLAVRKTPSISASASRLSQPQHQRRVPSLRRTLCLCCRIDSVNGMSTAVSGGAASSPAKGDEYRLPTSVAPTHYELAFKTDLESSPPSFLGEAMIDLDVKEDVKQIVFNINPDLKVTNIAIKNLDQKTSTALSIPLKAFSIDKDQERGKIDVSSLPGGGLTAGSKAKLFVRWEAELGDNMMGYYKSEGDADANGKKPIYALTQFEPTAARRAFPSWDEPLLKSKFTVSMIAKEGNTVLANMPAVSTKPWKPASNVTAESPLKDGYEIGSLLTNVYALGKTEGKTEGKTEGKTEGKTEGKTEKGKTEGKTEKGKTEGKTEGKTEGKTEGLPKSKTEGKTEGKTEGKTEGLPKQKTEGKTEGKTEGKTEGKTEGKTEKGKTEGKTEGKTESSKSDNWQITKFETTPLVSTYLVAFACGEFKFLESEFKSKLTGKTVPLRIYTTPNEIGQAQFGLDIKKWALPIYEEVFDIPYPLPKLDTLVAHDFDAGAMENWGLITGRTTAYLYDEKKSSLSAKKRVATVQCHELAHMWFGDIVVALHRVAPDIHPTSSNDFYTLQHALTASTMSWWDNLWLNEAFATLMGELVIPDRIWPEWKVRQEFVGGHLVSALGLDSQRSSHPIEVDCPDANQINQIFDSISYSKGASVLRMLSSVVGEETFLKGVSLYLKKHLYSNAVTADLWAGISEASGMDVSKVMANWTLKVGFPMISVEEPGDGTIKLTQNRFLSTGDVKPEEDETIWWVPLQVKTVGSDGKVSTDAKAFPEGRSTTYDLKGSDSFKLNGDSIGVYRVKYTPERLAKLGQQAQSFSVEDRVGLIGDAATIARAGYAKTSGSLNLINELAETEKEYLPLDQINLALGKLNATWWEQPKEVRDAINALRIKVFKPVVERLGYDHKENDAPDVKELRTLAISTCAGAEDADVLAELKARFQPFLENNDDSRIPPDLQRITYSVAVKHGGETEYNKIRAVYDKPPTPHTKVDALFALGVPKDQKLIDRTFAMFTDGSLKSQDYYIAFFALASNRESRRQIGDYFMENFDRFDKEFSASFGIAHLIKGAFGSLTSKEDLAKIKKFFDGRVDISRYKLSVHQVYDTIQAASDWLERDQQDVEQWLKQNKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQU2</accession>
    <name>K1VQU2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA processing-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD02996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQU2"/>
    <dbReference type="FunCoup" id="K1VQU2">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQU2"/>
    <dbReference type="eggNOG" id="KOG2318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010564_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQU2"/>
    <dbReference type="OMA" id="DHDFAID"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="301"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="763" mass="85808" checksum="EC39B0BF1DEFE3DD" modified="2012-11-28" version="1">MSDPRFARLQTDPRFRRPKQKQLKTEIDDRFKDVLSEDFGKIKGKGEQGKISTGIQKLMSARVDKRGRALASTSGADEMKRFYRLKSPEGDEEEKKPIDYARGEGYLSSSGSEDEDSEDEESEIEEDVIEIGGKQRLRPHQLQADSESDSDDDQLKVDLSEDEGGINLDEDEEEDEEEEDEGPGVDPTTRLAAVNLDWDNMRADDLFILFNSFLTPVVRKGEAAPPPPGKLLSVKIYPSEFGKQRMAKEDAAGPGGGIFKVAEKKKSKRPQRKPKPESSDEEDSDDEEDEEMSEDEEGSDDEELEDDGLDAEIDNLEIVSDVESVNGEEDIDMDKLRQYQLERLRYYYAIATFSTVEAAQAVHDELNGSEFERTANILDLSYVPEDMTFAEDEVHDEATKESKSYKGNDFVTDALRHSKVKLTWDQDDPNRAKMTRRALTREEIEDADFGNLVAASSDEEVEEEEPEDEMPAEKKSKKAKAKERKEKLRSLLLQADDENGDIWGKQGTAWQEELADIKGDKAAKEEAVEITFKPGLSKDAEDENLTSLERYKLRMKEKKREKKEKMELKRAEKDDGKKSKPKDDFFGDSDSESEVEVETKPKKGKEAKGKSKTKAEKPVEDDDNGMDGIVEDDVHHHFSMKDVLAAEKEKKAGKKRSRKRKGKAGPDHVPELGPDGFKVDVSDPRFSAMYSEPAFALDPTHSKFTDIPANREILKKTREAHSAARGGAANGTDGGESKGLGDLVQSVKRKAEGSGRHRKRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQV8</accession>
    <name>K1VQV8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQV8"/>
    <dbReference type="HOGENOM" id="CLU_1240907_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQV8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="212" mass="24257" checksum="6A739C1B72C43F63" modified="2012-11-28" version="1">MPLTFPRTDWTGVGFGFPPYEEGQYVYELAYAAYKASIAWKRAEESGDWTLIDRYCWQLCVYDKAIELPIMTYADWEEDMDELIGGVYDVQARAGIPTPLSPPTVAEIQPFILAALRYRARATTLLDDEVPPRVARPFELSELGRFAAMYHNFIHVEEWEDEEGNPRTRRRRIEEKRYPEPCYETEPAEPAEPAEPAEPTESAEAAESLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQW8</accession>
    <name>K1VQW8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQW8"/>
    <dbReference type="HOGENOM" id="CLU_1367098_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQW8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="22570" checksum="A0EF3A474CA960AD" modified="2012-11-28" version="1">MVAALDFAFFPQICHEIIAQSDSKTHNKLRLLCSAVKLELDKYQCRDVHVSIYRTDRGIPPLCPRHDYEGPSPVPVPPSVRHLSATLYDTGPNPTGDTKLAHNCTTVWVKLELLESLEFLGVTEFMISLLTPRVQQFNLVYDEQDDAITYLKVLKEHERHPLLSVVVEPTKNTSQTAADVLQGWLSKLIQRDVTVKLHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRE9</accession>
    <name>K1VRE9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRE9"/>
    <dbReference type="STRING" id="1220162.K1VRE9"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436273_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRE9"/>
    <dbReference type="OMA" id="QERDEYP"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="627" mass="69733" checksum="6A37B80DCC709052" modified="2012-11-28" version="1">MGGRPGDSARLPAPDRPSHQSPVSTPYHHFSPHHPSQDLHPSKDGASTEHGSQSLPSSSRSGRSDHPSHAPHYHPTSAEDRRPRDVPTRYERGRSDRRSASPIYPASSAVRPRSSSPPFRDRSVRTAEGDAQRFPGGSVDSEGFEGSGRSDDPQSYHADGDRRQQGSRGEAESYQPPEDGAATISSISEPASRPRSPHKRRTRMLMSRNQWQALSRLWDRTIFPATAEREALAREIGLTPRQVQVWFQRQKRRRERETDAANAALVASSPYFAAARTAELPHGWNGGPPPRHWPEAEDYRSYGSSSSRQPGMSAPHLHNGFDHRPQDGSRVSHGYGPARHDEHPRQGWPELNSQRWRGSHLISRDRDPEREFDERSLDKERPYERGRQFVRELTSERDDSLQTRPRGYYYAGPPPSVMQEDRWQPAPRPTLSPHHSYPPPPLPPQPHYSGRDSRSPHPPWQPGEPSLIATTERTASPGGPATPGSGRHPYYYPPDSRRSPMDDQQRPIHSASSPGSGRQRGHSYLPPSLSALAIDGPLERDIRESRIPSSYMGDGGRETVGPAHPGLQGRNASPYAHPPSSRPHHPSSPGPGSSRPPHSREPHQSDSKRPGETTSPPRLPSLSSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSS3</accession>
    <name>K1VSS3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSS3"/>
    <dbReference type="STRING" id="1220162.K1VSS3"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1448690_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSS3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21022" checksum="53BDF6BCDB0725EA" modified="2012-11-28" version="1">MLTTWGFDGYIRWLRGVKATYQQRRDWMVDALGHAFHLEFDGDSSFNPLVAETQFGRSVTGYARPVAGSAQAQWDEKRGASSALGHPLISFIPPSAGMFVFVGVHLTHHPEYERLGDEVLMRKLWKRLAEHLVLFAPGWAFDSCGVHNIGGKGMGYFRLSFSILPYETMQSGMVTFAKVLTEFMQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTJ4</accession>
    <name>K1VTJ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTJ4"/>
    <dbReference type="STRING" id="1220162.K1VTJ4"/>
    <dbReference type="eggNOG" id="ENOG502S4C3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105924_1_1_1"/>
    <dbReference type="InParanoid" id="K1VTJ4"/>
    <dbReference type="OMA" id="GHRTEYV"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="228" mass="24715" checksum="FE3FA42147749954" modified="2012-11-28" version="1">MTSKPTIALRDLQPGDLGYVLQQHGEQYWTEYGWDQEFERLVARVLGEFCPGPRERGWIATVDGQRAGCVFLVKAPARETEPVGHVASGDAPGHETSSTPATTSPPAAGSSATVGHSTAAELAAEPSTTPSTAPPTQRGKREEGDMAKLRLLLVDRKYRGLGLASLLVDACLSFAREKGYRGVELWTHANLTAARGMYAKRGFAKVNEEPYRGLGGHALVAEEWEMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU17</accession>
    <name>K1VU17_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU17"/>
    <dbReference type="STRING" id="1220162.K1VU17"/>
    <dbReference type="eggNOG" id="ENOG502RB9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2016823_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU17"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="123" mass="12904" checksum="68C75A18297AA748" modified="2012-11-28" version="1">MSNKPIATDLVCLVLFEISAPSRRPEHTPRQLTFRDQADKQLAGLSTFGGIMGYTMAGSVPSLAGGLGVGSVMAVAAMRIHDGLPYGYELAAASSAGLAIPMINVLALELLSCENGRFPGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU27</accession>
    <name>K1VU27_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU27"/>
    <dbReference type="STRING" id="1220162.K1VU27"/>
    <dbReference type="eggNOG" id="ENOG502REB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1020101_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU27"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="273" mass="29732" checksum="49058D7A43EC8835" modified="2012-11-28" version="1">MATSANALYVVRLVLGARNPTAPRAALASAVARRNVSTAAIGQQTDAAAATGTTTDAAAVTDIDFLEPETGEYNDAADFLPERSSTAPAPIPWPTIFPHGEARPIQRRPCDLLARLVSENRIEQARKVYDELHALHTVPVHRKLYLKAALSSLQPTAEGRADFLFWLELYSNRGAAENHPGLKATWDPVVSQILYEHLDVDFIGKFLELGGRKGLLPALMPHFTHVLATMAAPSVSEEIMQRSLAAYINSTTSKTSTSRRAEYGGIHSRPDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU59</accession>
    <name>K1VU59_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU59"/>
    <dbReference type="STRING" id="1220162.K1VU59"/>
    <dbReference type="eggNOG" id="ENOG502SCBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625841_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU59"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="438" mass="49268" checksum="CB9F61BC16D95490" modified="2012-11-28" version="1">MMPPPRYFSVREEFKPHRHPGYTPAQIEEIQDSLVARGLPLDIAQRCMDYGEVWLACERTNSRRVCVRSSGAEPRGLRGLAWGTGQEDEMDAEYMRFREEETAALARRRREARERAKNGEPEPGTRVELQVDDNDDGPVIHLQPGTTTTVTMNGDGAQQFESVVSERSFESEWGLLDSPGNVWYLVSSPVGCSTIPPPPTKEHATPLAESPVLAPLASSLALGGLTSVLFSRIGAASTIIAGGVTAAAAYAFSSIARTERKRMHEHELRTNREYWTQHAVISANEEAEEHAKWMLDKRRGERSRNGSDETLGWEPTEEKKANQTWVRRIEITTFSKDQGWVDDESLYGQYEGSFSFFEVSLLRNGREVPGSRFEIQRNVCAGQVHLQHDIILDLDHPLTRMAQKGDRVVLWARAMYPGWTNNVRRASVTIYSAPFPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU71</accession>
    <name>K1VU71_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU71"/>
    <dbReference type="FunCoup" id="K1VU71">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU71"/>
    <dbReference type="eggNOG" id="KOG2864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023360_1_0_1"/>
    <dbReference type="InParanoid" id="K1VU71"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="270" mass="28403" checksum="B36D6AFCD2D03276" modified="2012-11-28" version="1">MSDKSGNPGKSGSDAGLSSALRAGRALILLQLLSRLLTFALNQGLVRLASPAVFGTASIQFDLIAATVLFLSREGVRNALLRGGTSNGGGRLAQIPQQLGLAVAAATVGLYLYTSPASTKAQKDFYPALALYVMAALNELAIEPFYIACMRDGRMRVRVQAEGGMAIVRAVVSFACLYLFPDHALLGFAVGHFAGAAWLAARYISAGGALQGDSGDEKIRSLAWANTRQSVVKHVLTEADRIAVGRISPLGDQGGYAVAMNYGMLQTWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUI2</accession>
    <name>K1VUI2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUI2"/>
    <dbReference type="FunCoup" id="K1VUI2">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUI2"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020031_1_1_1"/>
    <dbReference type="InParanoid" id="K1VUI2"/>
    <dbReference type="OMA" id="VYAFVEC"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="UAS" evidence="3">
        <location>
            <begin position="160"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="524" mass="58307" checksum="EDF830D5EC89A33E" modified="2012-11-28" version="1">MTPDQQAALDQLSAITAAATEAERDRDERLLRKNGWNVEATVNEIFTGGGQMPNPSETLKVETESSTFAPADGDMAPRRRLSGTAVPVTARRQASVGLGLWETIVWPFSVLASILTGTWYFFIRTFVPLSLLPHLPRFLLPPPSRAPPTGPRDPTTSSLRFVRDLETLTGGSSATGNLPDFFIGPYREFLAEVRKQGKVGAVVLVSSEHENDEEFKRDVLSDPEFVKCLKDNDILVWGADISSREGYMVAQTLLTTTYPSITFASLLPPASSSVSGSTSPRLTILTTVAGPPSTVTNTASFIQVISTQILPRTNAFLQRLRRERLRLEEARHLREEQDRAFREAERKDRERLDAQRQQRELERVQRERAEREAEAKAKAIEDRQQWRRYARKHLLPPNEGSVRVAVRTPLSAERHVRAFTPGPSTLPLFVYAETLLIPPEDSPDSDPDSPPEGYEHAWDFRLVTHFPRRTVEMTEVGGEEVWSMVKSAGGALFAEKIEGSAWGDAEKASTAGDSSDEEILSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV21</accession>
    <name>K1VV21_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="15" type="ORF">A1Q2_05091</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV21"/>
    <dbReference type="FunCoup" id="K1VV21">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VV21"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_2_1_1"/>
    <dbReference type="InParanoid" id="K1VV21"/>
    <dbReference type="OMA" id="CASQDWG"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023216536" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023216534" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1145"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="122"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="454"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="726"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="728"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1000"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1058"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD00603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130675" checksum="744F1429A1FA7142" modified="2012-11-28" version="1">MAQPPSTAPLEATPYGQKSNPRLRKLAKKPLKPLKLAASAYHSVRSGLATPNSGQSAIGLEDELAGLNVSDGSTKVNRSVTSTSASSNGTGGLDPQISINDKNWRGRKKDNMLVDPVMIAQAAKGPRKPLDGEEPAAWLRVRVVSADGLVAKDRNGLSDPFVTLLVPPGSRHTTPVVKRSLDPVFPAAQSTFDFPIYLSLAAVIGGRGLEGVVWDKDLVRKEYMGELCVPVDHWFPSAQPRLWHEQLPVQSFELFSSRRKHRVSGNVQLQIGFLPGPAEDTQDALRKVQGVYETILARTLVGGQFGVLGVPAHEGIGTVQLTRSQTDGDDFLDTSTGMSVITTAVMAPSVGAQQSYSRQYSYDLPDDGLSSSDEDGDMEDALEGDDDGWLRDGLPTDSPEADGVPQSEPLSLPPIMPGVDDLGSRRSSAASLQSVAEAAPPSGKSRKIFRRSRLGRKKGKSKDYNFGHDHNILGIVVMEVQSASDLPRLKNALRVGWDMDPFVVISFGKKVFRTRVIRHSLNPNWDEKLLFHVHEHEENFTIQMTLLDWDKISGNDHIGSATLPLAELIADAPSPDPVTGLYGEGVDGKHESREFTLPIVTNKSVAWELKHKPALTVRAKYEPYGALRQRFWRQYAMQYDADDTGSMSWVEMTSMLDSLGSTLTPQTLESYFTRFGKSPEKDELTFDEVVQSLEDEVTKSSSAKRTIGKPNASVEVDAHDLDARLKSMPQSTPGSATPSVHQGTAPPSTYNSHSRHISTASNTNIPYLNVENTDDSSSPQGTTEAGSPMASDADENSDPANDYVERIINIKECPLCHRPRLSKRSEQDMITHLAVCASSDWSRIDRIMTSTYVTSSQAQRKKLTKLLNKVTAGSYSLGANSANILVQDRMTGQLQEEKMAVYVRTGIRVLYKGPRTGIAGARARRMLKSLSIKQGIRYDSPQSAADIPGFIAFHRLNTDEIRDPLDSFKTFNEFFYRKLKEDARPVEDPGNPDRLVSMADCRMMAFNTVSEAQQIWIKGRDFTIAKMLGSAYHEQWQNYVGGSLCIFRLAPQDYHRFHSPVDGKIGKITKIEGEYYTVNPQAIRTQLDVYGDNVRQIVPIESPQFGTVMTVWVGAMMVGSIVDSVVEGQEVKRGDELGYFKFGGSTIVCVFEPGRVVWDQDLQDNAAAALETLVRVGMGIGRTPEMARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVA1</accession>
    <name>K1VVA1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVA1"/>
    <dbReference type="HOGENOM" id="CLU_1950322_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVA1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="157" mass="17429" checksum="2F22A0721C387570" modified="2012-11-28" version="1">MPNTRPRSPKASETGEDDAEYEALRHYVRHELLGHIPHVERFHVDPAVVRKALEDDPWFNNFEGFERCEVPAVIVFQEEDGTISDGAGNEVRAITTEDGRTEYVKDGWRKVSKEKKDEDNNEAEASKPDNAAINKDTAKSASETSSQASGGVDAKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVW8</accession>
    <name>K1VVW8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVW8"/>
    <dbReference type="eggNOG" id="ENOG502RBAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385425_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVW8"/>
    <dbReference type="OrthoDB" id="2536714at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="750" mass="81009" checksum="7A75895CB7B672AF" modified="2012-11-28" version="1">MPPSTASTPVSSSVDDEVPPPPELAPLMAQQQEQVPELFSLEHLLRQAGYKETRVFTPEAEKLANRYKRQFSDEQAAELADLYASVGQKHNMEIRHMTQQHVPFRSSSSVLRSVVLQDTGANQAFKDGKRTNDREEDESWWGSMLINRAAETVGKSISAMSPPSNEGSLERINIGLGLAKGGNGVRKAKSNWELTRRHSTSGPDQEDIPPIPRLTQSDNTLTTPPRPSSAAFNASAPPAIDSVFTTPPRLTTGQPVFEDDEGFGCPLPMDYEIHGGSDDDMYNLGYTDSSGTNSAASSLGTQIEPRRMSASPPLRDAADVLAGLGLGPSDVSDALASAPPADLEDEDADPHEIALAEQEAAAIGQRILASTVEYDEDSDESDVLSPPPPALSIAPTRRTVAVSKPRTATLPYPATACPTTAIADAMGDLLTDPLPDRTPSVVASETKAKLRAAQSAPMLRSKSQPFLCISPALVAPPTLQIMAPVICDSQSDMAEDLPPLPTPAPAPQPTGFSSLALRAKKSLKALRSTFWAQQAEVPPPLPTPEDSFISNKTPILTPRLDWAMQGEHFAGWNDNKGHGFGRQRDSIDTMAEIGDPFANAGDVEIDYSKSFFYKPSTPPGPGGSSGHQGSPTPAGRMRRQRSVKTLRAQLLRPVAAPPVPQIPPMYRKGKGRLPTTPPLRNKNTQRPAFEVPKLALHSPNAWEEGRPPVEIILEGDEWDARSIVENWGSGIRRGRGKSPSYYDDDEDFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVY4</accession>
    <name>K1VVY4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVY4"/>
    <dbReference type="STRING" id="1220162.K1VVY4"/>
    <dbReference type="eggNOG" id="ENOG502QV4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026640_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVY4"/>
    <dbReference type="OMA" id="LAWFRYY"/>
    <dbReference type="OrthoDB" id="8300246at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="445" mass="49158" checksum="AFBE57D3C016F44C" modified="2012-11-28" version="1">MTGSDFVSPDELRARFCAALSAMYRSEVPLYGDLVELVDDLIPDRLKVERHGAIRLGKPDELAMIARLFGLFGMQPVGYYDLSPSGVPVHSTAFRPVNAESLAINPFRVFTSLLLPELLEPELRAEVESVLAERDIFHPRVREIVAKAEAEGGVRPQDAEELVQKALETFKWHDTALVTRETYDKMHAAHPLVADIAAFRGPHINHLTPRVLDIDAAQTGMSARGITPKTIIEGPPKRECEILLRQTSFQALTEPITFPPSSGAGTPASAEMRRSISGSHRARFGEIEQRGCALTRKGHAMYVKLMSTVPAAMDNEAHQQNLAKAFASFPDTYRGMFDDGLAYFEYDLVSAPPKPLPLPELVASGHVALEPVTYEDFLPASAAGIFQSNLDERDRSRSPSPNRGSASKTAFEKILPVKLHDSFELYERIQEKSLRELENALGFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWA0</accession>
    <name>K1VWA0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWA0"/>
    <dbReference type="STRING" id="1220162.K1VWA0"/>
    <dbReference type="eggNOG" id="KOG3946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045003_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWA0"/>
    <dbReference type="OMA" id="THWAYQK"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000081">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005137330" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="105"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="404" mass="45436" checksum="F868E3A5C83226B0" modified="2012-11-28" version="1">MRRPLQLWSMLAGLLLLLSVALAERRDFRLLTDVEVEAIVKLDPPEWPAVDAGHMEHLLVPRVSGTENNTKVQEYLSSVMTGLGWAEEKVAHKENTPLGEREFTNLVYTFDPDAPRRLVLSAHFDSKWFDGQGFIGATDSAAPCAYLLDIAEALTPLMKARAERIKAGNPRLSATVDELEDSEVSLQLVFFDGEEAFHQWTSTDSVYGSRNLAEVWEVTPLADTHPLSRRRGSPSVLDTIDVLVLLDLLGAKSPQITSHYKNTEWMFRELEDIDAYLRKNKLVEGDDSWFNALGRGGHIDDDHRPFLQRGVPILHLIPVPFPDVWHKMADNKDALDLATCRRWISIMRVFTARYLGLALDVALEEKPNGKVVTTAVGADLAKQTSKEVKTQERERDELVRTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWG7</accession>
    <name>K1VWG7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWG7"/>
    <dbReference type="eggNOG" id="KOG4550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020272_2_0_1"/>
    <dbReference type="InParanoid" id="K1VWG7"/>
    <dbReference type="OMA" id="PGDWIPW"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852466" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="479"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="613" mass="67489" checksum="EFC96DF203588E52" modified="2012-11-28" version="1">MRAGLLALALLVPGAKAFWPFKKERFTAETLLDAGSLGLDPAWQYDAGPLLEFDKVVYNVIPADFNGDGRLDLLVMTGDEDQWWSKSDKSLHMTVVLGNESGFGQRWDLAKSGRHQPFVFDDEHNLLPSLLGYLPDGDRDNNLRSWKNTDGSPMKIGRPSLFPIDSGCTLANPHSSAYVDMDGDCAPDVVLHCQSPKANNRKLQVYENRGTEGYVVANVIDLPTYSRAVTFADMNRDGAVDLVFATCKRHMPSSGLGEECSINVAYNIQAPVCSGEWSQYEKDGQLRCRGWGELCQSDPNWSFDFSEKRGTFLSVPLEELFPGQNVELLLSVPGNAHIPLPLRPGDFDVDGFPDLLVTLKTDKGTQVKILKNVPCGKGVAGCAGLPKGSRGLIVAQGKGYEALEAITDAEGASWIDLDDDGSLDILVQRSGKQKGSKAHVTFIQNNFYHDAFFLKAQVLNGACDRDCEPADGGKKYSSLGASYSGATFKFTVFDTAGKRHAQQVPQLPQVAHHALYSPHTYIGLGRTNNYVEVIINPPWALSPKANTNVKTRSTEWRSELFLHPGDWIPWVAAAVVGTVLFLGMVVVWLNDREKKEDEKERRRALHAINFQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX56</accession>
    <name>K1VX56_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX56"/>
    <dbReference type="eggNOG" id="ENOG502RBD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1421365_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX56"/>
    <dbReference type="OMA" id="WCDARIS"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="205" mass="22387" checksum="8B8792F212638D1D" modified="2012-11-28" version="1">MSATNGAAQKLAYNIRPVDPEQLRLLRHEVLWPSIPLSAQLAEYDYAPGALHLGLFLPSSDLRALSIPPSYDSLPVGVVTLVPAPYTQPPQPLPPSLASSLPEFRGEPATQLRKFALHPNLQGRGLGRVMFDACVSALQKMDREEGQEGREGQEGRRLLHLDARTNQVGFYQRLGLSVLDENVFTKVGPNGDGPAIPHLRMGIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX85</accession>
    <name>K1VX85_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX85"/>
    <dbReference type="HOGENOM" id="CLU_891941_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX85"/>
    <dbReference type="OrthoDB" id="2830113at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33571" checksum="E05B7A9F2CC21DA9" modified="2012-11-28" version="1">MVTIPPPPVAGDDRRSVSVPNRAHAFHGVAGGSARPGHFGHHFAPTCFDIAPVRRRRLPIQRSESSSASPTPPSASSGSSSRSPRSDQGRLSSSPTTSISLSTSPYPSSQHTNSPQSGAGTPSWSASSGSIALASFGKRSASASGSNAPAQPVLRSGVDLTSHYRNYVRALNTRTFDLICRYVAARVTHNGVTMGHAEFCSLIPPGAVFMPEDIIVDFTNRTIAARLYVEYPCTTGCTTLWGVAPFAADGEEERGRTECRRKICQVDEMAFYRFDEEWRIESVNVMVASRNPIRSGSGSDDDYRERARSGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY41</accession>
    <name>K1VY41_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY41"/>
    <dbReference type="FunCoup" id="K1VY41">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VY41"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014456_1_1_1"/>
    <dbReference type="InParanoid" id="K1VY41"/>
    <dbReference type="OMA" id="ICNTDIT"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD05516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="773" mass="83998" checksum="B8B566423F24D3C6" modified="2012-11-28" version="1">MEDVTNPFSTSPSRSPSATPTRSPVLSRTTSHSSTNQRPSAPGSVAGASSPPPTQRASFPDPSKEPRRGTGVLPGPKPKEGFCCERDRQIAQGEEISIIDAFKTTEGGKSSYITYVIRIGALQGLYPVLIIPPIPSKQSITDYAVKGQSKTKEDVATIATRKRLLEDFLRRVCRHPILGGEHVFHRFLEDGSEVLHSPPISLLPKNPLHAPSHNPTFEDVNGNDDPDSTSSTSYIAHHLLPNPSPTHPLHRPDLRFQESEAFTDKFHQHFAHNMEKVNRRATKRWSEHASDMSELGAQWNGFSLMESGPLGTAIEKVGQAVDADFLATTKMVSYNGLLLTNPQLQDWEQNASEPLHTYTQFAQLIKSRLSFRHQKHVQYELVQEALENQRDKLEILEAAEREARRLEQALERGGVAAGASASAPSSPPAREDSSIPELARPSVRRSGQSFGLLSAVKHSLSGMMDVDPEATRRANIAKTRDNISQLEDSLQASAQDLKYASTTLQADLDRFQRQKVADLRELTIQLSTIHRDWCKANLEAWKAAQAAIDEIPDHPNKVPADAAARVASIDRDRDLPPVPQQESRRSSVAHGSPAKRDSLSMGGARSPSKPLSPGMGARSPSNASNPLPKMGQLNLDSPFSETPFSSHPLGEPSAPANGLDPLGGSMISPRHTPKPAEDADTPKWPSSPVKSSPPEQKSVDVPPSPKSTQAVKSLNEEARDEDEPVESSKGTLVDRKDSAGSVGSKSSTTNIKPADITKDTKPKTEDVGPLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYG9</accession>
    <name>K1VYG9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle membrane protein (V-SNARE) with acyltransferase activity, Ykt6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01159</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYG9"/>
    <dbReference type="STRING" id="1220162.K1VYG9"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_346192_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYG9"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="816" mass="89769" checksum="D353FFFA17DFF12F" modified="2012-11-28" version="1">MKVYQLTLLSVSSGNPAKAAVLGSAQDLSSFSMFQRGSIAQFMSFFAQVRSPKFTRGLTKQTVAERTPPNQPSSVEENGYKAHIMRIPGRTANSPGMAAVMITDMEYPFRPAFSLLNKLLDENASLLAQLPNPDAAPSAASAAASAFGGNPSQNAAGGLPPAQKGKLEGTLSTYLAKYQDPKQADTIMKVQQELDETKVVLTIESVLERGENLDNLVERSNTLSAQSKMFYKTAKKVGVWIEYSADFPAKLLLHCHVIIIPLAAMAHSYEGFGKHIVVLSDDSDSDVAIVGSRSRTAHVSTSPVFVRTSRSADVYTLVDSDTDSDGADLDSILASASLPKRHDSSTTAIRQHGASIVRAERLTFSETATTAEMSRRTLTVSTSRSILSVLEENNWDEQTLPTTSAAESPEPRKKRRRTATTSDAGRAASEAKDRERAEARAERERRKLQEKNDRQRARDEAKVTHALARTSLTRQAAREAERSYQKKLKELRKTKSEALREVEIHMAHDLMLPSSPIAGAMPEIRKRVEDSLSRLVTVPETDTIVGGTIRFLRHVSAEWSASEKRFVPLDNPRTEWETTTILVASADEVVDRILLGDGELAEWIADVRLTLFLAPDEQLLLLVRGLEKYHSKTRSIVNKAFRDSARAGLSTGRASSTEASTTFRTRVEKQQVEAELLQAQLSQYLLVVQEDIEDWIFNLAGDIAAKPLLEKSHLPFSAPDHPRKAVDAMPALELMLQEVNGLTASAASGITTRYPSFRKLMEAYEGEADLNTAENLLMDCEIRNSKNGAAASRRVGPSLSRKVHWLFRGQDPLALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYH7</accession>
    <name>K1VYH7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMC hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03856</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYH7"/>
    <dbReference type="FunCoup" id="K1VYH7">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYH7"/>
    <dbReference type="eggNOG" id="KOG0018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="InParanoid" id="K1VYH7"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="484"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="248"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="639"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="777"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131177" checksum="5EB4485D85796766" modified="2012-11-28" version="1">MPLRRLELHNFKSYRGHVNIDFGVAPFTCIIGPNGSGKSNLMDAISFVLGVKSAQLRSTQLKDLVYRGRKAAEGVPELMGLDADAPESQNLSQNGNTDGRTASVAAIYEDAVGKEWTFKRTISTSGASTYYLQGKPVTYVIYNTQLEKFNILVKAKNFLVFQGDVEGVASQDAKALSKLIDRISGSLELAPQYEAAKLAQEKAAEAANANHAKKRSMLTEVKHFKDQKAEVDQWEQLRAAKRHLMWKLYHLTQEINEAKEEVEKRSEQLNDLNGEVRENELKEARKHQAETMIKVKKQEANVKKAERAVEEKQPDLVTLETQIAHSEKKGRNTQAIFEQVERDHKRQAEELETLEAGRAQINERMEEAKERQRQRNVKAGKALSADDLAEYRKLKLKDELDTLSEREGTMSDKVKSLEAEKKRIKAQIDNAQAERERISLQETEINDRLQEALNKLLQAGVDRRESEREAKMKETLASLRRVFPGVHGRVIDLCKPTAGKYDTAVQTVLGRNIDAVVVDQEKVAIDCIEYMRQQRFGQATFIPIDTIQVKAVPEKLRTIDRRARLAIDCLEFDPAVERAMQYVCGSALICDTTEVAKTVCYEKRQEVKCVTLDGTVFHKSGLITGGRGHATRKFSDRDVDGLKATKDKLVAKLHELNASKPKEKADESLIQDLARLGAELTEAKDDFQATQLRIKGLKKEISAVDQDIKMMTPEKKKRESALTAAEAQSAQLASVVESEDDKIFGAFCQRIGVANIREYEDVQLKVAQEENEVLQSIEFQAAQVKATEERLAQLQSISSRELRNAERLRENKEELENEIEELQAEIEKQREKLEKYNTKHEKASAEVEEARDAARQAQRRLDKMLKEISSYNDGIARCGSDRHAIYRKCRLEDIDLPLESGSLSNVPIAIDDDSLSPAKVNDYGIELDFTILEEDDKENSADDHGQELEAQINKMKVDIERVTPNMKAVSRLEEVENELRDAETEADEARQESKRAREEFLDLKKRRCNLFNKAFTHMSKCIDQIYKDLTKNSVVPQGGMAFLSLEDAEEPYLAGVKYNTMPPGKRFVEIEQLSGGEKTMAALALLFHPAPFFVLDEVDAALDPTNVSKLARFVREQSEKGVQFIIISLKSTLYEHADGLVGVYREQVMNSSQTLSLDLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYR6</accession>
    <name>K1VYR6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,6-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000217">
        <property type="protein sequence ID" value="EKD04652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYR6"/>
    <dbReference type="STRING" id="1220162.K1VYR6"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474236_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYR6"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="575" mass="62180" checksum="187752E99EE1C125" modified="2012-11-28" version="1">MHIPPHANGLSSLPALPSPPPKPKTTGLAPPPTRARAPTWSGDGLAPPRPTPVRSSSANALRQNDLLVDTSGSSSATRPLQLGGFPAVPYQSPQQPGMPPNATPGFAPLASPGYPAPSPLALGQQAFQFPIQQTQFQANNPFGQQMQMGMGQQQMGMLSPGSAGVSPMHTGSPMHTGMSNGMNGMYNGMPNGANGMMAGPVHDAHGSPGRWLRQCRCLHHFDCTTRVIVVQCELNVAPMVLSPFGGTCCAVHNSQESAEGDGVVRRRRHGPLHNLQRARPPVVPVVAVVYVDLDADNDARPAEHLACVLARPQAAELALARPQLRFPDLGAAAPVRHRPHDTDTECLKPMADWGRGAEVWKPELWASEGELRRLRAGEDAGKVLGRASVIVGVEVDVHNRHDWHNWWPRPLQIVQWTMASAPHHPITLSALLRIVHRTASAAEWAQDHWRDIQFALHNNDTGRAMEMMKTTALSEPSAGGPVGIMDWTGPGIWTDAVLQYLAARYGGQWTDLRGLDKPLRVGDVIVLPVTGFSPEVGQFGSQSRDDPQAMVWHYFRGSWKADSGGMREVEEHVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZG9</accession>
    <name>K1VZG9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mei2-like C-terminal RNA recognition motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZG9"/>
    <dbReference type="STRING" id="1220162.K1VZG9"/>
    <dbReference type="eggNOG" id="KOG4660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405543_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZG9"/>
    <dbReference type="OMA" id="DFKNCCN"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="3">
        <location>
            <begin position="466"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="631" mass="69794" checksum="5C5DBA426861AE74" modified="2012-11-28" version="1">MLATPPEEKCAALPSVTPDSPPLLRTSPSPKKPQRQAGPNDAKSDISRSSSKISLSAPSRREGVRRRRPPSPLKGFETYSSQTYQHCNSSMSTPGSHASAVPVTPHALNGDGIWLSSEFSPTAFFSPFDNAQLELPDLARKVKDITRSPQFVNEATIGHHLLDLTPYRAILVRHLETHGFVILCFHDSRDTMKVYNKLLISSVRFNRALGPVSLQCTAIRRDVVRAKVWKDSVACIDVTVKGPVTVAGVKIFRAEYYDARAASKAVQVLDGAQIGDFKFTVKITTEKEGDPFLSRPISPSPLPQPSSAPQYTFASAAYGNQHTRQTFLDTPNQRNEAFGPSSSAPRTASRFTRSFSNSFELPQTQPPSPTVRSTISRTHSVSAGTADWARITRNGTHDESLLQSQTQAPRWSDPVLLQSVLDQMSLTARVYQQTSAQQPVVPHNPQAIPVENIIHKDRIINGLDKRTTVMIKDVPNKLSREELVSILREVVPNEFDFVYLRFDFNNHCNVGYAFVNFTSIQALLTFVELKAGRKWNLFASEKVLQVSTRCFEPLLTVRNSHVMDALEEWRPQIFYSDGALKGQPEPFPEADHPARHQQRGSFSRAPFVTGASGSNGGSISAGHNPYRQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZM2</accession>
    <name>K1VZM2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000161">
        <property type="protein sequence ID" value="EKD05012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZM2"/>
    <dbReference type="STRING" id="1220162.K1VZM2"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042555_4_0_1"/>
    <dbReference type="InParanoid" id="K1VZM2"/>
    <dbReference type="OMA" id="INEFPRI"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="408" mass="45099" checksum="D374D980429D9A62" modified="2012-11-28" version="1">MSHLVTRPRHSIINQAFESKLRFPSARPLNADGFGIGWYDPVLAGQPSLLLAGEEDSTPATPQPTSPQIAATAVADAKVASGQVDPTLRTDTPSPLDAGTGGVSACVNGAVSPVADDDQTEAERVASVRHLRKREREEEDERPCVFKSISPAWSNANLLRLAEKIRSPLIFAHVRASTMSGAPSEDNCHPWVFDRLMWMHNGEINEFPRIKRALQAALPEELFLFPAGYTDAEWAFMVFLSHLRDPHAKHFSHAELRDAMMKTIRTINDLSKEAGITGPSLMNFVVSDGHTVIATRYISSRTSEASSLFFSSGTSFDEYDPGEGMYRMTKADKRERIIMVASEPLTFESKDWIEVKTNTMVVITPNIPIIDEYWVSPQDPAAHHRDPEFAIQSGYGLGFNYNRSAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0H8</accession>
    <name>K1W0H8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0H8"/>
    <dbReference type="HOGENOM" id="CLU_767658_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0H8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39588" checksum="41A3E0BB57AED1E1" modified="2012-11-28" version="1">MAGPTLTTPGASALDPSNFPHITDLIVRYAPVSALPSLRLTCRALSAAVERRLQVHLITTPHESSSALLHLWHRGWGYSPHTRTLDLYFEAPTPVREDGVSPEQAGSCTLPNLKHVRLISWLEDGSARCAPLVTRSVIVPLLHRCEDDINPIAPQTALDLVKFERFIIVYPPEPLDIELYQLHPGQRAPVEVVVVVPPTALAFDINSPLPFPVRVPVTFPNLPPRFGDLPLLAANSNFMTLACAAGALFDSGHRLTVVGILDWVFPLRDMLRLKDDNVSGTAAVSAGSEVALKQLMARYLETLGCASEKTEAILTGVKFPSEEEWRVQVGEEEYRLAVGAYAVRKAYLDSEHFSPWTAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W334</accession>
    <name>K1W334_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W334"/>
    <dbReference type="HOGENOM" id="CLU_1295223_0_0_1"/>
    <dbReference type="InParanoid" id="K1W334"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="213" mass="22934" checksum="846B7C4377D32E73" modified="2012-11-28" version="1">MAYPYHRHVHYRPRRCGGFLRGVLLVGLGFWIARATERRHHLEGPRGPWAAPPPNSQSSNSSSSTSSAPSEGSEGGVWGRGGWCRRRREEAIPGGPVAYGPAEVRGEDVPAVLAALAAFQRAHPDPSAPSGMPVTPATPIAPTAPPGERDEREKESAPPVTEASTASTDVAQSKTLTDQRKMEEDLARIDRMSAALQRLREAIEKDGHGPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3Q8</accession>
    <name>K1W3Q8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_02111</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3Q8"/>
    <dbReference type="STRING" id="1220162.K1W3Q8"/>
    <dbReference type="eggNOG" id="KOG3896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023311_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3Q8"/>
    <dbReference type="OMA" id="RANMIRI"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD03528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="54402" checksum="AB4B2129B0E4EC18" modified="2012-11-28" version="1">MVQNVTYHCPHLDTPRPPLAPSFASSSADLSELPSLYFCEECDAIRCSECISVEVASYYCPNCLFDVPTANVRADKNSHEIGWLFEKPSSLASQAVNVYPIPEEEQAEFDQLKDHLENYIQDTPSVNPKTGHSRRVPTRHIGKITQAAARALGRDVPGSPLARPKRRVAGDDKGRAGWDELGKYEAKHAWRSDEQGNGGSDIDALREMTGEDITPLDKRWEGAWAVPSTAKDAVPERIPLQAKLTKRCPSPTCRHILIQPDTKSVRMLIKMVASNYLPALELGRRRHRRGETVPAGMTEEDMERRRKDRRRARLAPGQEADQDMREPLKAGEVLAFTNPLYDPIQIRLSAPYQKHSIPPNHLIHIPTAHFTVGALKETFAYDDEDDDDSGGEDEFDDRKRLSLTRSTRAHPGASDVEKRGNVSKVGLELEVLPSAEEGPVEQFDLEVRFTYRADDAEGAKDKEPEYKTFTFWTRVHAGGVVPDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5J4</accession>
    <name>K1W5J4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuole organization and biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5J4"/>
    <dbReference type="STRING" id="1220162.K1W5J4"/>
    <dbReference type="eggNOG" id="KOG2280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008909_2_0_1"/>
    <dbReference type="InParanoid" id="K1W5J4"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 C-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="382" mass="42897" checksum="69C60565ABFD80A0" modified="2012-11-28" version="1">MHLLALRISQYLGLRPDPVLKHWAVARIARSKSALSQESDAGLCSAIVEKFEKEGERASYADIAKKAWEAGRVRLATMLLDHESRAAEQVPLLLEMKQDKIALEKAVDSGDTDLVYHVLLRLQSALSPGDFFHLLDDSLTPALTPAVRLLQVYARENNRQLLRDFYYQDDRRVDAGTLYVEEAYATPLADDRAELLRLASKSFAEDKDAAFESKQAEDAARLLQMQAGYEAEADHRVALRGLSLSDTISALITHGLGKRAEALRSAFKVPDKRWWWLKLKALAAAKNWTALETFAKSKKSPIGYEPFVRHLLAVEQPGQAALYVPRCEARHRPDLYVECGLWGKAAEAAKERGDKSKLEEIRQRAPSGLAQREVEEVIRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6F3</accession>
    <name>K1W6F3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6F3"/>
    <dbReference type="HOGENOM" id="CLU_511100_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6F3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59648" checksum="46ED16FFD1205DA0" modified="2012-11-28" version="1">MAAKLDVAFYPHIFDQILASCDDTSLRALRATCRRVQSHIDSQLQRHVVHNACGRAWGGPEAYSHRSGVFCSSWGSPDVLDILHWNEGLFPDPGERDGAKAKIKAEAIENEGKLAWWRNARLVRLFPDEDVIPYSRKAMVVRFVADPRLPSSGPAGQIRGVKSVWLSLSQRPIIGAHDEPPPPDKEVQPEPRFILNFAYHLNEFPRISVRRSAEDGPPESQFKLCVVVFTPGGEEEDDMVRANERAWEEWKREMEQEEAEARGNAQMDEQAIAVLMADEAGEAQAEETEWVTTDGETDEDSEEDDGDGDGDESGQHDEVTQGSPEPPIDEEELAAEEAELDLVYQPPPPEPEVAPTPAVPSETLHGSRNGATVPAPLPPVPPGKEHIKLTSMRAFWGLLRFFDAYTMGPCEGHGLQGDWHEMERCSRVPSLLSYIFVGTERWIFDLTNVADDVPPDEGVEFDTAAWVADVDALRAERPDTPDFQLMVEAGLARWYEPSQAEVYNDVLDHVFYETDAGFQSRYQGENYDLIMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6H9</accession>
    <name>K1W6H9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6H9"/>
    <dbReference type="FunCoup" id="K1W6H9">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6H9"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044099_1_0_1"/>
    <dbReference type="InParanoid" id="K1W6H9"/>
    <dbReference type="OMA" id="AFKHACS"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="359" mass="40041" checksum="9B41CA2F671486ED" modified="2012-11-28" version="1">MSSAQRRKLSGLFIQLTNRVWQDLDALGHLDTRRLGATIDVEQSAVRLLGSLVLNLWDCGGQDAFLDNYLSAQRDTIFSNVAVLIYVFDMTSTEWEKDLHYFEDNLSALRENSPDAGVWVLMNKMDLVDSEDPKRTKYQERRDEVLALNDKLSKDVDGAGGCRCFPTSIWDESLYKIPNIKLISAHLTYLRDMLGAAEIAAFESETFLIMAKSGSPLDSDSSEADDVEKAKGVPGLDPERFEKISEIVKSFRKTCQKTGEQFYGFDAQFDGVTVVLEPMTRNTFAMVVGVDPTVEAGLVKYNMNQARLHLAEVGTMTTMTRKCGVCEHNVKLEHNISYKPSNPSGRAWDDVGIDVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6Y9</accession>
    <name>K1W6Y9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6Y9"/>
    <dbReference type="STRING" id="1220162.K1W6Y9"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_2_1"/>
    <dbReference type="InParanoid" id="K1W6Y9"/>
    <dbReference type="OMA" id="AMVPWED"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="153"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="553"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="593"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="685" mass="75170" checksum="CA745E1C8AAF944B" modified="2012-11-28" version="1">MAQSPPGSASGSAVGSATGPASSRNASARHQQSARHAQPRTRRDSPSSSQVAPVTITSQTLSPPTPAPSPTPTERRSYAPLDLGDKDSVLDEDEDVTLAPLDTLAMPNASKLMRLFQALPKSERFAFLISLVGDLQLNEALVVSSKISPRLKRDFLSDLPVELALHCVSFIDDAQTLTRMARVCKYWNDLLQDECLWKVMHERQVYRPKLPSAGPNPPPTAVNATETQAPTKSSSMRDNTSPMWGRAGSSSRSVQRAQSSRERFRDAYLTEHNWLKGGKQLAMHSSMGDSVVTSLVVNDDFIIIGMANAKIHVFDATTGYYCRSLLGHELGVWAIVLVTPRGRNKGLRRAEEIQRRASFAGSTSGSSSVPYRPSSAAGDRRPSRTTRRMRSSDVCGSATSWGVKRTLVVSGGCDREVRVWDLAEGKCLYALRGHSSTIRCLKVLDGRPIAVSGSRDFTLRIWDIDRGRMLRVLEGHEQSVRCIEVAGNQVVSGSYDFTCRLWDIDTGDCLQVFEGHYHQIYAVAFDGERVVSGSLDSTVRVWDAGSGECLAVLPGHTSLVGQLQLSGDRLITGGSDGRVIVFDLTDFSTVHRLCAHDNSVTCLQFDDRFIVSGGSDGRVKLWDIRTGTFIRELTQPCDAVWRVCFRDDKCAILCQRNGRTVLEVLGFKPQDIAARPMVNARAPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7F6</accession>
    <name>K1W7F6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_08136</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W7F6">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7F6"/>
    <dbReference type="eggNOG" id="KOG1972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248768_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7F6"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1577"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC97598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1603" mass="180714" checksum="671C879CA2C5BE4D" modified="2012-11-28" version="1">MQKMVGHKAKMMHARRHAEKVQMKKKLKAHDERNVKQKDDGAVKEGALPAYLLDREGQKDAKALSSAIKDRRKDRAAKYSVPLPKVRGIAEEEMFKVIKTGKHKGKSWKRMVNKHTFVGEGFTRKPVKLERFIRPMALPELKTTFQLPILGVKKNPQSPMYTSLGVLTKGTIIEVNVSELGMVTTGGKVVWSNKANNAGLQQLATVKEGLQLTPSRDPPPNLHLQTSATTTAQAGISALHQPRYHEHERPTDVVLVVPGVAGAHGGTFEGSVILLIPGHRPRRASEVERQKTISAALRRARPRRDRSRDRAKDGHRTKDRDRDRLRESNIDRRRDDGDRKRDRDRDRERDRNHERDRDREHRRDRHSKREDRQRHHNHSKSPREDDDEKRKEKEDRRRRDRERAEELVNAASKTESIKMEDDGMPWYEARTTARPAPAPLPSKAFFLDTVGDRDVARWNLTSSESTPRYRRDAGRYSAKPLEGSASRHLGRILLRPSNEESEPLGDYTLIHRRKAILPSTDLPDYRVILHEKEESEDELEGVLGQVTTLQDSLKVKRVEFERHLSQYPEDVKEWIKYSTLHLQEQPSSVRKTGDDQAAQPTTRANAEVTLSLLERALNSHRANFRSTELHTAFLHAAEAFWPPDKVTQRWKNVISQLSGQAPEDEMIRLYLGYIDWREGQGLGSSGNDGGIDEVVSVYIEVLDRLRSTSDAGYNERAMGAFQALMEITFFKPDHLRAPAPPFDRELWFMGVLQEFEDFWDSEIPRIGEAGGKGWKEMHASLEEASIPRSTAPDFSSSVINPHERWLEAERHAETALFLPGRARDLDAADDDPFHVILFEDVAPFLFPVQSPMARLQLIFAFLNFLGLPFTPPDVPTTSPASTDPQLRWTIAKNEGLRAAFWPPRPSVKRVAWQTVGGEPMEAEVPRAMSSPFGCPVKAWMSSRDSLFAGSHWFRDINALDLAHVDIELTRNVLNLLRPLVPDPSFVLNLFAFEAALSPKTDNLALWDGYARLERQRGKVAAARQVYVTAIQSAMARMQDSNDENLELDEAELWASWAEMEWEEGNDERCLEVLVMAAGMQRQAIVLKTRQSPSKLFLGSLFSYYTDGIEAVRDSLSMLIDQLPEDHPQGEEMLQLLVKIVHFHATRHSTPASLARGILESAIAKYPNNTEFLSLYLWGEASGRVYGRIQRLVSDLTGENKGIVAMLWSVWSEAIGSARTFWDPRGGGAERVRRALDRSVNTMSGKRSAVLWTLYIEFEIMMGRPSSAKALCYRAIAAVGGCKDLTGENKGIVAMLWSVWSEAIGSARTFWDPRGGGAERVRRALDRSVNTMSGKRSAVLWTLYIEFEIMMGRPSSAKALCYRAIAAVGGCKALRPHFTPRELGSIAESMYERGIRIRVGTENFWVDEEEAEGEGSEEDEPAPIADYEYGMLRTIEADEEAAPALSGNIGGAATPTPRTSEPVVLVPGTAARDVEEGGIAGILKASSHPLALLCLYFFRSAAIAVYVLCGLFTDNYVLSIVVVVVLLSLDFWNTRNVAGRTLVGLRYWNEVDEEGESAWVFESRDPQSRPPNPIDAKMFWIALYAYPVGWTALLIVSFLKFNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7Q5</accession>
    <name>K1W7Q5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000186">
        <property type="protein sequence ID" value="EKD04923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7Q5"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_233143_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7Q5"/>
    <dbReference type="OMA" id="DQVGWIW"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1821"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1764"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1831"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1852"/>
            <end position="1872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2049" mass="216974" checksum="F9E970CFE06D2CF2" modified="2012-11-28" version="1">MSPTPGAGPDDPSDSRRSSGSSQSTTAFATPPSSPKLNTSISRIPKLAPSPVENALSRSSSSGDKRSNAPAPTHAPGPAPPHFPAAQSPSSLPVPVHNKLLARKSMSAAIPHSSRRYSQYVAKNGPSPSSSIPTAIPVFRGGGGGSSSGNVSSSVTPTPSPVPSSSTAATGRAGIGRGASPASSSASAMRRTSSAEGRRAARTHHREGHAPPMPPPLPPGAAPPLASVAGTSTTSSPSPSSGIPRRQKSSSSLGRRKSHIPTSNLTPSPRARPMSVKPPARVSSAAAPAMLSAQHHPPLPTSPPIPNGSPAAFGFPNGSSAFNQDLPLRSASLRATSDSRPASPPPPPPPPPARADATFPPPEPQFRRPDATHSPGQPSTSSVDVDDGHRHVDDHSPARPNGVARGETRPSRSSSLSSASLPASPLARSHGFQQQVSTQTTPPKDQPSPYSPRTATTPHSPTAPLSPPLSSNTVGPNLPLRNESLPQTPLPPLATSPTRSTSLAPEPPAALRSSTSSQGSTTTVVPDPIETEVPPLPNTSNQAATSPVSTVSSTATPGSPEVAPVPAPTTPVPAPAAATPPVPNGRVTPDSSRNAKASESPRAPRTSPRPDRKSPGLTIDPPPPPASSHNIRVVSPPPIPAPQPSAVPPAAVPIIPAKSPLRPRTGRLRSGTNTGAVPPVPKLPDNIPPVPQRPSSVHHVSTTLQLPEQDPSASGSSSQPPASESSGATARAEEANQTTDSATTEEPSAVTTASSTSSEPRTSPSVAVPSQQALAAAILAPVQNTYGGIPLTARSDPAESSAQPFAKDLSSSLLASPIPFDDSGPPSAPASNQNIWVVSSGGSASRPTSFLDASTSTASTISTSVSTTDSLLGRSEAGIMEDATMYDKRESLDDEIISSPTALCDLCPSPTNCPHTTLKKQTSLPRVTPLNLDVHSKVLPELPLASPNQPLSPRTPTTPARPQHAQQSTAPPRSPSMPTLVRKESPASVASQTTTESHDHLVPRPRMRGPGPDGRSNTTGHSPRPQSMVITGSPLPSPISPSLSRRAHLIREIAHTERTHANDLALITDAYVGRVLRTDSGLSSQGSTAVEADSNASTPGASTPGVEAVQPQRGHARRPSYGLAADEHGRVEGKRHHQERRMSGQDSAWAQAWSGLMSPVLKSPKEREGHHQGNGSMDGMYQSSAGGSSSSFQMVTPPVQSPANSSAPASASTNNGFTRLGGIMNPQSGKPLSSWDIKAVFLNINELAYISDELAKEFDQAIGDADSDSGTPGVDSVGDRLGEVFMKMAAASKRLLELQQDPGYAQYLNDCWGQVKSHTHAWNLDSMLIKPVQRITKYPLLFEDLLACTTPSHPDYHCIQKAAEGARTLALEIDEAKRRKDVISSVMSKSQSTISLVKDPKAGSGGRLLNLRRFKKDRLNGAGGDNGPPEITPYAQAQLKELVSKLENSDKQVRRMTREVVEWVNSNKVLLLNGRDTNLDLLRWYTLEGRVMNDVRAAKVAAYKSVLDSCINTIWHEMNERINNSVLATLGKMIDAARNPLAIIDRLNRKSADYARYQAHRHAKKSIDRLMIQEATDYVAIHTQLLEELPVFLEGYSKIFEVAVCALTMAQTRYYGNMRDITRAFTTQFLSEPTESRLTETGEIQEVPIDISTARGIHKAWLDKFLAPNNIAKGLLTTSADFRSESRRGPGSRSTSRTELRSPNLRHAPSFITRPKSRNESRAGSESRNGMRAESRTEQLRSESRAEHTSDSGDERANRRRSRSLSGQSTAVSDSESSSRFASLIRRNSQRNGSAKKGHRSLRPPMPEGFMERKANEHTLSVATSEDRLSSHTQQSQQSQQSGDSQRSQTSALTQDSRLSLSPRSHQSQLEKTLSHDSTAEEIASRLSFGLPRIHTESTPLLFDSFGMGGKPYRAVLDDAQVDSPMEITPTDLAPATSSSSPRSSVTDVDGDPWAATGINYACAVVAEFDPKQLGDRKFMGLPFLTLEVGHEVEVRHEIGRVAVLPNFPYAHLGVENDGAVVCRAEDGRYGIAMCSFLEPIQEPVASQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W827</accession>
    <name>K1W827_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone deacetylation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W827"/>
    <dbReference type="STRING" id="1220162.K1W827"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268240_0_0_1"/>
    <dbReference type="InParanoid" id="K1W827"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="462"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1101"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1225" mass="132729" checksum="DED68F4C7BDFD4B5" modified="2012-11-28" version="1">MSVTVDTRPPAGVPPQDHRAPNDPTPISSLRSEDVDTETSRRHPTETGYPSTAGPSRQVDMDTTPNGRRDSGTRGSKSSDNSIGDHPLPTIPERPSQARPSAVATSSTYPNTPPHDSPHTTHESAAAPTPSSPPSLPTPAAASPEAQSKQSKSKRKRNATAGPSRQSSAEPERPGHWMGEDNAVIRCICGFTEDDGFTIQCEGCNAWEHGLCFGYQDEASVPDTYFCELCMPRKVDADRARALQAPRIAYTRLVRPQESTEQGKKSRPKTKRQRTERASASERAAAAEDTSNGGNGSSAPTPAEDTSMAPPNNKPKRKAGPSHKPRNASRALNDLKEEDDFFRVVPWEMEYTPIKDNIIRGAPARHAMTQLYREWIDVDENSPPRKGRASYHDSGLPSPTETGALRLSPDMFTSPDFSTLGPPVPPVTLSGTDLSSLSAPTSIRPVDDNHCFLPLKYIEPSSGIYARPTLYGVFVNEAVNAGGFLGEFRGEIIDSASYRKDPINQYSALGIPKPYVHSVGPPVNLMLDARSYGCDNRFVRSGCHPNAVVRPLLFRSTEDQDQKPKLRFGIFASRDLSKNEEIVLGWEWDDQHVVHTLRAVIDSTLKSGASKPPIAPETMDRLALKFDSILTNIFGTFQSCACTVTTDCAFSQMRRLVSGQTFHGVSGSRARKRIDLGELIGAVRGWRRRELEAAEAAKARRFASSGEWELWRTGPAKSPSDDDEVKHDESTPSRPASTADQSDHGMDVDEPAVGDGEPPAVDEPPSEAVAEPTVAAERDDDETEDELPPPAAASAPEPEPEPKLDEPVEPAATTEAVPSADSADSAPAAPAAADAVEEVAPILEEPATADLAEAAMVTEEPPKTDEEPAKPEEALVTGAEGAEPPKDDAMQVDEVEPTAEPPKPEPEVATEQKDERMPPQRYQKPKLRFGIFASRDLSKNEEIVLGWEWDDQHVVHTLRAVIDSTLKSGASKPPIAPETMDRLALKFDSILTNIFGTFQSCACTVTTDCAFSQMRRLVSGQTFHGVSGSRARKRIDLGELIGAVRGWRRRELEVAEAAKARCAHSKESTVNHRHSHRISCHRSNHFRSKLIDINADPVTMAVTGSSSKTPARGTSVRGKGRDKASAIEIPDDSPVEVGSASEEEDEFEEVEIPGAGVATPDGLSSVAGPSTVATPDADGLDTSMMSVEDNNEDFDEDEEEQVISVEIGGETQEEKEKRIALALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8C1</accession>
    <name>K1W8C1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8C1"/>
    <dbReference type="FunCoup" id="K1W8C1">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8C1"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="K1W8C1"/>
    <dbReference type="OMA" id="WIFPAIQ"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="168"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="650" mass="70221" checksum="242969F8E2BB3204" modified="2012-11-28" version="1">MTPPPCSCPVTPCQRPGHRMELIKLRELSQWLSLAATQTSPVGLTPLLASLSPTTSTHPPPVCGSVDPRPSLGHGCAGINKLTRCLAARSLPPPSSSHRYIISSHPLTPGFSPDHPVQPVMSHALSNTSSEERAAPYSEKDKVDGTAARVDDAGPKRRKRHTLGNTATIFASGSAMFSDGYSNAAIGPVNTVLNAKFPEVMDPKHQGANPRASSNRNLLSAMAFAGMVIGQLSFGWVSDKVGRKLGMFICTGMIFVFSILCAASSGPKGHPQVLINCLIAFRFLLGIGIGGEYPCGSVTAAEATENTGVKKNHQQRLFVWATNSMLDAAFAIAWFVALVLLWIFGWDHKNIIWRGTLALGAIPPLILIIARLFMEEPEAYKKNSMRHTRIPYWLVLKRYWLRLIAVSVVWFIYDFITYPFGTYSDVITKNAAPNATIYETLGWSCLINSFYLPGTIIGSFVSDWLGPKYTLITGLLLQAVFGFTLSGAYERFFPPNGHTPGGLAGFAIMYGVFLACGELGPGNNLGLLASKAIGPTAARGQLYGIAAAIGKVGAFIGSYCFTPMIDSFSKKSEYLGNTGIFYVGSALAVFSALVAFIFIPNIRADAMIDEDALFREYLAEHGYDVSLIGEPGYVDPEEVTDMKIGPQRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8R1</accession>
    <name>K1W8R1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen metabolism-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000141">
        <property type="protein sequence ID" value="EKD05168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8R1"/>
    <dbReference type="FunCoup" id="K1W8R1">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8R1"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029402_4_1_1"/>
    <dbReference type="InParanoid" id="K1W8R1"/>
    <dbReference type="OMA" id="SRCQRSC"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="214"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="289" mass="31385" checksum="0FB967B165BA8DCE" modified="2012-11-28" version="1">MSGFTLDGKPVDDKLPEGWGQRQSRVGRVGDWSRDQNPNEPRERPGLVENILSQAARSGPPSTAASPVPWGSGNTLGSDETPSQAVPDETGGEEVQRRTLTFWRNGFSIENGPLHPYDVPESKALLEAIQAGRAPTSLFGVRFGQPLEVVVNERRGEDFAPPKRVTTPFEGGGHRLGNVVPDIAGTPAGDHNIAVKQEQDREKKIADAKPEVDESKPTTNVQLRLADGSRKVVKINLDSTVQQLRQVAEPAANGRPFVLQTTFPPRELKDDETIEGAKLANSVVVQRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8Z5</accession>
    <name>K1W8Z5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8Z5"/>
    <dbReference type="HOGENOM" id="CLU_891945_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8Z5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="312" mass="32818" checksum="D0CA224CEB208749" modified="2012-11-28" version="1">MNVHASAVTSHSPPLAPESVTDSFDLRYSHDIVAHSLSSTTSTPLTSLFTFEHPDLAADSMLTGPSLGPSAASPSLHRRRSFTLPSSLRSTRSRSRSGSAPPPSSMFSSSSSTVFRSRPDDAVMDLLGAVGWKLLSWGWLLLRFTIRLLINTAWVAAIAVPTVFLASTYLKIAARLRAVDEHAAFLLLNVIALQQLRTALFGSISKGVSELEAQNSCATVEYELTPDRAARRVIAGALFGVFAKGAWGEASLVYGAGPHVIGIGGHGRGGAVTIKGIVECGGSGAAERRSERGEDCARGFAGVGRGEAVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W935</accession>
    <name>K1W935_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000132">
        <property type="protein sequence ID" value="EKD05338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W935"/>
    <dbReference type="STRING" id="1220162.K1W935"/>
    <dbReference type="eggNOG" id="ENOG502RTPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1020100_0_0_1"/>
    <dbReference type="InParanoid" id="K1W935"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="273" mass="30804" checksum="FAC31E93DFA8EC72" modified="2012-11-28" version="1">MRVNMRRMTPGAVFNSFLGILDLKLDCASVRRASIHAEDDTNKLTADQQGRRFATLWAFLWALSVIKLEVAKKSLFVAHLYVIDHAIAWVFHYIFYYAYWYTLKHDGTRVLNSQAQKDIFELALSREETEPLDAGRDKQAQLAHEIWNKEKGYALGVIAVGFLLKVYFIFLMYSYAAHLRSGTYHQLPLTTHANQVTQIEARRASLAATALDEEIEMERALADVERIERGARASEEAVGSPRTSPRMNTAGNGAAATGGRPGKSRDSDEFSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAR7</accession>
    <name>K1WAR7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAR7"/>
    <dbReference type="HOGENOM" id="CLU_678236_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAR7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="406" mass="46114" checksum="2362D83733A77E3B" modified="2012-11-28" version="1">MSSPTKPRTTGESEPWANGLEGVTVLPTEECLQNYPLPPIDSIGLPAHLGLFPRTNHIENFGYPFYLFEDGHYEWKLRWVARATSRAWTRAIAAKDIDLVIPPRERLRDPQGKERQALLEESLCLAIADKALEINVWARNIRAMYKIRNLTFEDWVDCDLGRDDIDHRLQAHFPSEPWILNTDGLAELAMRVCTYALNTVYEMLYDSREQVDKSFESFPLGLMEKWYPDRDDLPPERFTCVVLEESDTDDPHGRESDTAETFLDVEGNVREPDSAELQRIERWEEEWGSPMPPPQPVLPTLADWWEAKARMEEKQQGKSAHEDAPVAHLFACPSYAQAARRNVPATSGPSPQDSLKQAVAPVGTGAELQGEGDTGGWQESVGRRELRRRRKARQSGAGKEVPHTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD09</accession>
    <name>K1WD09_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD09"/>
    <dbReference type="HOGENOM" id="CLU_1448697_0_0_1"/>
    <dbReference type="InParanoid" id="K1WD09"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="187" mass="20862" checksum="7EB347744900170F" modified="2012-11-28" version="1">MKGRLANPAKANPRSRPRTKPLNSPLLQHEDRCEFLTRDGQTESQAPWAKVGFSSPFRAKGQPSSSTRIRHELAVSASLDYDIPEDRVGQLTPATPPRRTRYRKGELSYWSTELTASPQKEAGSKWKTGCNCVPRERHARLALPPPVELMPAPFRPSRPESGTGRGRFCEAQRRQPTTVCLATSIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDG7</accession>
    <name>K1WDG7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDG7"/>
    <dbReference type="STRING" id="1220162.K1WDG7"/>
    <dbReference type="eggNOG" id="ENOG502SC5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463954_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDG7"/>
    <dbReference type="OMA" id="ASESRIC"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="588" mass="63357" checksum="ECFE1666E79DCDDE" modified="2012-11-28" version="1">METDTRLGLIRSRDEFDASCGSESSSPHRSKSARTSLASTASSSPGDLNDVPTNANNDTEATEDRTADALVEELECGMCAGVFIEPVALNGCGHVFCGSCVMQWIKSMPKYPPSLLPGDPVPEPISCPHCRHAPVQTATPCRLAKTMVGILLASRPDVARPPNEHRQAELLYKSTTGVIKRPANCNSTNSGVRAVRVTPRKASGGVPSRFLASRFRLNVIDAFELTDSVPRATASAPDGPLNVNLLCRDNWTEMYHLGIYLGNNEHMSAQYIYKQILEWLRTPEGLDSGGILAMMNRADINLRLRTGMADEMQQAVMSAGDSASESRICGGCADEILCWWMRELKKPEALQARPADVRNRPNCKFGRTCSRQDSDDHAKKYNHICDALPEDEARTMHQDDILPAQENAPEQDNSGAESDDGGSDDENEIPSNFFDAGTQWEATVVGVEMTCHTNGLNSAWVNNTGAAYASSTSTTSTQAFSIANLVNETSGPPSSADTPARAAQAPTWQAATNSQPAVLGLRSSHQGTHQANGYPTLFDSVGSSMSMPLSSKLPPLQTGSKLPSLFDMPEASTSARKLDSSSMDVEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJ14</accession>
    <name>K1WJ14_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c oxidase subunit V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJ14"/>
    <dbReference type="FunCoup" id="K1WJ14">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WJ14"/>
    <dbReference type="eggNOG" id="KOG4075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070101_2_0_1"/>
    <dbReference type="InParanoid" id="K1WJ14"/>
    <dbReference type="OMA" id="WYISYGA"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="170" mass="18525" checksum="EDCF934CB3D80876" modified="2012-11-28" version="1">MSLLRTAAIRATRVPQLARAASTTAPHVVSSRSNQDGALLSNIEAHWSKLPAAEQYEVFQALEEAQKKDWKQLTTDEKKAAYFIAFGPHGPRAPILPEGGKMKVFAGVLACVAAAVSVFAFVRSQAPPPPKTWNREYQEMSNEYLKSQNSNPISGISSEGYKGKGMVMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WK84</accession>
    <name>K1WK84_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WK84"/>
    <dbReference type="STRING" id="1220162.K1WK84"/>
    <dbReference type="eggNOG" id="ENOG502S1PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_1_1_1"/>
    <dbReference type="InParanoid" id="K1WK84"/>
    <dbReference type="OMA" id="RMENQIF"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="135" mass="15166" checksum="DE538EA5414B0B46" modified="2012-11-28" version="1">MSSLQFSSYDGYGQYALENFHYSQAVRLGDRIECAGQGGWDPATNAIPDDIEEQIAQAFENVDLTVRTAGGKGWDQVYRVNSYHIPLDEKALNAMVENFRKWCPNHKPLWTCIGVPQLGLPAMKVEIEVVAYDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKK0</accession>
    <name>K1WKK0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKK0"/>
    <dbReference type="HOGENOM" id="CLU_1836535_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKK0"/>
    <dbReference type="OrthoDB" id="2565338at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="140" mass="14305" checksum="D27FCF7DBBF6C293" modified="2012-11-28" version="1">MRMRGYEAAHGPPKANPAAAPAPVLAPVLAPAPIVVPVPAAAPSQPPLTSSKASISQASPANVSKASPKHHLKGSGPSPNPAAREAMRPPKYGGYSKRDQLGSVNDSWGAEESVDDGGVRRLGLFQVEPEPPSPPASPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WLQ9</accession>
    <name>K1WLQ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WLQ9"/>
    <dbReference type="FunCoup" id="K1WLQ9">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WLQ9"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014853_3_1_1"/>
    <dbReference type="InParanoid" id="K1WLQ9"/>
    <dbReference type="OMA" id="LARWNAY"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="267"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="762" mass="83751" checksum="95281FBB95345DFD" modified="2012-11-28" version="1">MSPTVGLTLVQPPPSCHAIDVVSLSSAPTTTPTTATTTMSAIATPSPIPSTPRTPPPLDPRAITDPSEIAAQLAALTRREAEVTLALNALISDRAGVDGALQRLQSLTPHIDSLSAQVDGVGSSSSSRPLPALRRDSQQSLGLGSPGLGQHGFGSQHFDETVLGQENEGLVSRVSRVYETSERVGGKVRRLDEEIGRVRQSADVVTEVLELKNSLANLRGYIEKHDWENAARACRRAMDVRPDVLNGGFAATVVPTTESPLPPPQQLDELRQVLLTTFRAEFELAADRRDEQEISRYFRLWPGIGAEDEGLAAYGDFVVELVQSRARKDKDGQRSSPLYYLAQLTSLLEAIAHIVDQHQPVIAKYYGRGRMGKVVARLVRESDRVVQRLVEGWEEERRVGRLIADTESSTFPLLSNPALLPPLFPSLVSTAGQLSLANLANTTSNISNALQSYAPRVKGGVTPAATPIPEEDTGPDARDVDRILGELVALGGRWALFRRFIFARLREDAEPDAATSDPSKRAEGADGAEDSGEGEVSAKTADVDESILTSSLSQRAMENLLRTYYLPLEEWYLRTAVEKAHKLDQADAGSKPYLSSILDDTFYLVKIVLSRALSSGSLDTLARMRQRVAQVLERDYIDVLSRKMEAVYAAGQGVSYDRAEKERREKDQRTAVIIYLNDLDFSGTYVERLLSEWRAQPPAVWDESELPRVTEELELFGDLALKFRLKCKAGLDALFANVLRPRVRQLLRLQSSHCHYAWTSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM45</accession>
    <name>K1WM45_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM45"/>
    <dbReference type="STRING" id="1220162.K1WM45"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2160184_0_0_1"/>
    <dbReference type="InParanoid" id="K1WM45"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="11980" checksum="2A79976EBF9BD1AF" modified="2012-11-28" version="1">MLRPSLLRQAVRTGSLIRPAARAGPSVARPAALPLRPFSVSSPPGARNGVHFVDSKGNPIKTIEGNEGDDLLSLAHEYDVDLEDPESFDKLPEADDEENDMLDLAFGLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMH5</accession>
    <name>K1WMH5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_03380</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMH5"/>
    <dbReference type="FunCoup" id="K1WMH5">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMH5"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="InParanoid" id="K1WMH5"/>
    <dbReference type="OMA" id="TNESVCA"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="305"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD02324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="746" mass="80337" checksum="A61C4D23282ADB2D" modified="2012-11-28" version="1">MSGQPPFNPGAFEFRPGQTFVPRSQQQQGQGQPGQQQPYDQYAQYGQQQYGGYQGYPQQGGYGGYPQQGYGGYQQQHQQQPQTRAYEPPQRNVQGFQPPSFGNPGKPVSLSIGGGGAPKAAPSLNIGGGAPKAAPSLNIGGGKPKAAPSLSIGGDKPKAAPSLSIGGDKPKAAPSLSIGGDKPKAAPSLSIGGDKPKAAPSLSIGGGAKKEEPKKEEAKPAEKKVEAKKEEPKAAEAPKAAPAVAAAVASEPSSAKASGTSTPTNFSKVSAKNDADTVFQDQQAAGADALRDLYGGAEMEDPNLKTHLNIIFTGHVDAGKSTMGGQLMYLCGAVDKRTMEKYEQEAKAAGRETWYLSWALDQNKEERAKGKTIEVGRAYFESDVRRYTILDAPGHKTFVPNMIQGAAQADVALLVLSARKGEFETGFERDGQTREHAMLLKNNGINKLIIVVNKMDDPTVQWDQARYNEVCTKITPFLKAVGFNPKNDVTFIPVSAQLGQNMKDKVDSKIAPWYEGQSLLQHLDSMQIQDRDINAPFMFPISEKYNELGTMAMGKIESGRVKKGDTLLLMPNKMSVEVAAIYTETAEEMEMAFCGDNVRLRLRGVTDDDVQPGYVLTSPQKPVHAVTAFKADVSIIETPNIISSGYTCVLHVHTAAEEVTLSQLLHYYDKKTKRKSRRPPQFAKPGMLVSALFVLEQPLCLEKWADYKQLGRFSLRSSGSTVAIGKVTKLLSKDDLPDVGGLSIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMV2</accession>
    <name>K1WMV2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMV2"/>
    <dbReference type="eggNOG" id="ENOG502SCZ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1204714_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMV2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="221" mass="23353" checksum="C07C48A34F613DB7" modified="2012-11-28" version="1">MGLPHSAHAAVVLFMTLTGFILSILIVFSGPFVPGIWFVRTESAGQFTTFGVYGTCNETACTRRRGGYEVSGEAVANRAMTGPMVMPGLHSRATLHTAGIGERRAGSASGREPSYSPRRDVVLIGFTTWIISVVGWSIVLRASHIEGGSGKLGPAIWMGLASVLASLIAMVLGVPTDAGPGTVDMNPPSMLQPEAGRTAGAALAPRDGYWHYKHTTRIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPU8</accession>
    <name>K1WPU8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPU8"/>
    <dbReference type="HOGENOM" id="CLU_594729_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPU8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="52907" checksum="B6BFD8EA12BA88C4" modified="2012-11-28" version="1">MPSIDWLSFPHILDEIFDQADSSALACLRTVCRHFKAEAERRLYRHVTVAATYPGVPEVQFISSNDLNIPGLHGLLDLTPGLRAVTLQRLEQHTRILDICRHPFDIDHAPADLTQCLWWMKTLKLDLVRVASPRSLWVPYLEWGASYWGHRSYADFATYPVHLDTRIVPPPPAQKAVFFIDLTPPYPPLGTGGVSRIQPLPFNAVRYKACPESGPRLLLPPDEVPYRQRYFRYDFAIHGDIFKCGNDGSCMRNHDGSRATTLVLNLRYEPNHPLLPAARWFVKSGRSSEPITQRIGPRHLVIIFSPTPYPDADEAFSWARQAPLIEINWEGALRLWRNGHRDADYGMLMHLWELAWPVFEEYQFDGGGEVTFVGLEDFRNVDLGLPTHIDDWPARKAELELRYLELNTVRRERCALMPLPDSYAPNFLMRDEYRAIVGEEVWEMETSEPLGAWSEPPHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSW8</accession>
    <name>K1WSW8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000235">
        <property type="protein sequence ID" value="EKD04064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSW8"/>
    <dbReference type="STRING" id="1220162.K1WSW8"/>
    <dbReference type="eggNOG" id="ENOG502SP7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421612_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSW8"/>
    <dbReference type="OrthoDB" id="2575524at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="650" mass="70636" checksum="A520E2F033C02990" modified="2012-11-28" version="1">MDAEAGPSRPPRPPSLPRSPRRGRISTSRSPVRSARLSVEVSVELPRLKSPARALPSASTTRSPDSGEDRPTKSPIRLPWPEASPRASGAGSGSESRSPTRATGTGSESPVRPGGFEHVVDALERVVDVPIERINTPRKPPPEPAPTTERTRTPARSTPARDPSPGFDLTPLPTTLPPGFSREPTPASVTSDDDPPPKSGLRLPVHHTPQRRPAQPPINGPIYVPADVFAVLTSPIAPLPSATDSSPHTALPPPLPTVAGHALRSLVPPVPKPMPPRPAHSLQNRAYVCIKISEKRRAELIARGVYDAFRDDEDAQFRALAPRKRYQHYAAGSNRVMVRNVTLVLARPEELPERFIERPGPALLEPYASVLKEDRLVNTLGEYVCGWKGCGAVLASEERLKRHVAKRAHAAQGAVAAEKTVYRCFWAGCEGPCFERVEGLIQHLSARHIAGRLRCPFEDCEMTSPTLAHLQRHAIRQHAPDAPLRPRADLPILPKLPPLPPLPVIAHADELCTHRVNGRQHASAYRQEQVRARIQRLCFGGPEPDTEAGGVTMMEQLALTPPAPSRLRLSRRFSSEATPSPASARTAPRASPHLRPGLAPCRSSRSPSRRSPRSTTSWTLRDPATCPTRRRPRTTSGLADGSSSPSSPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTH3</accession>
    <name>K1WTH3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTH3"/>
    <dbReference type="eggNOG" id="ENOG502SDHK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038956_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTH3"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="268" mass="28043" checksum="CEC1FF5920950FB7" modified="2012-11-28" version="1">MDLSGLDSSLPAGLADAERDMTDKFRDLAGQHQGVGGLPATLTRWRALGRRATAQSLVANVLTKQQAYQVGYSAALADVLSKVQSDIGAGEDAAVALARLMDWTEARQDNDDEAPAPTKPRAARPSSAPAPSMPRYTAPGPSSLSQRTDQMEEDSTPSRPAREAIPASSPIMSPAPARPGVKTMRSATRVPTSSHAAPAGAFNFSVPIPVNVTTSEEASPSQVGPTGAKRPMENQGEPSTPRGRAAKRRNEGQRGGRRRPSPGSSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTQ5</accession>
    <name>K1WTQ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTQ5"/>
    <dbReference type="HOGENOM" id="CLU_712104_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTQ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="41531" checksum="039FFE0E327D2D09" modified="2012-11-28" version="1">MALRVFGTPSPHASGLDLGEDNIEAGTFKYVAYRLDPYPAWFAGTVMRGLRGGQQSPPGPSMASTSPSGGPPMSLLLGSSVSSSSSFSMPSPSTPTSSSWPAPGGHTPSSPPKYSLGRNSRQRRISSHFDSAASTPTPTPQKRQSTIIYTSSSPHPAGQGHGRSSSLEAPHFRMRRDSSSSRDSGIESGGMVWIVQTAISLKMPLHTDADVVAIDEREFLRLRAFEENVYWPAYTRRLSELSTGRRALFIYDRQRASYIWDHEITPDEVRANPALGLKILRDQAATQYANRCLRKHEGLKPTNVVLKDGHEVPIQHPINVVPGDDVEVGPGVPGMALAPPATPTTPSFAFGAGLTAGFAGLSVNGPTISTVGPVTSPKEWESIKFTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0I9</accession>
    <name>K1V0I9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0I9"/>
    <dbReference type="HOGENOM" id="CLU_1533660_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0I9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="175" mass="19115" checksum="52EE247558398761" modified="2012-11-28" version="1">MVAHDPRLAALAHSAPAPTCSTDPPDPRYGATCYGLSIVGLSERHGRMGVCAGLDNEASKASRRSRFHVGVEERTTSAYPYCLSGPRNVTNGRKALRRALSYEWRFQLRPDPMPVVKLAELLAIARIALQAYGRTSLELAAITTNSNRNLGLSSNHSGDRAGLTYLIMIRQPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V123</accession>
    <name>K1V123_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V123"/>
    <dbReference type="FunCoup" id="K1V123">
        <property type="interactions" value="692"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V123"/>
    <dbReference type="eggNOG" id="KOG0772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014033_1_2_1"/>
    <dbReference type="InParanoid" id="K1V123"/>
    <dbReference type="OMA" id="KGDQYIT"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="513" mass="57037" checksum="B007B21B982AEF7E" modified="2012-11-28" version="1">MEDFGLPMSFGKKAKGPSAKARTKTVQANVAQTKREPVVPKEEAPKEESDEEIGPMPPSAKRKADDDSDSDAELEEEEDRTPVTHEIVLKDHTKLWDFGGMDARLRPFKSFEPNGSYFVRDLSYSPDGKHLLAISGTFYPKVFSRDGDDQKEFMKGDVYIRDMKTTKGHTAEINAGQWHPHDRDLFLTASNDSTLRIWDVNDRSKQKQVIVVRSKERGNKTHVTSCCLDGTIHVWKTASNLARPDRSSETAHEKGQEITGVAFSPDGKKLVSRSMDETVKCKLKRRYGELTPVWDPRSPRKPLAVATGIACRYSETNVSFSPDGKYVLVGTAIDPRDETAVGEVLFLSSEDLKVVRRVPIAKASVIKVLWHSRINQLFCTLSNGQVYVLYSPQASIHGALLPLAKMPRSGPRDLSFTTADLTPVVFTPDAHGGIQNAYGQSLHQQQKAAKRFKPTEPVSGVGRGGRVGASATAGFVQDVFKRRLEPTEDALLKYASEEEKKKLQAAREKQEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3P0</accession>
    <name>K1V3P0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3P0"/>
    <dbReference type="STRING" id="1220162.K1V3P0"/>
    <dbReference type="eggNOG" id="ENOG502SE1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325407_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3P0"/>
    <dbReference type="OMA" id="AWAYTAN"/>
    <dbReference type="OrthoDB" id="2554293at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="812" mass="91057" checksum="ADE528BD2FADC618" modified="2012-11-28" version="1">MLARSWRITAPAPTHASVLYRRVHDDNGAGPSRPRPASKRRARDSSRELRRLLPTLHDGVYGSYGGLMREIEKNGFDEDRLSSLDRHVILHHIIRRSKRGGPLAIQAAAEFMKGDATIRDRTMSVICYKKNHTVRKVKKVPIQAISSTQQPSIEDQQPLQIPPRLAEVLVLLETMQRRHLTRPKTLYDLVIRQAVAEDRPDIAAKAFVGLVEDWIIEGRIAEGADPEDFYRGGGPPRHKPKSTPLHQLWFSGVRTWRWPGEALSPHDRLDLWHPQHHALDERLRGFPMPVPTSPPSLVPHPTSDLLELILESLDMDPTTVHPRQYAATMRALAILANTILSRTLPINNIPPLLAMFSKANMYPLVYPESFTEEPRSNAWAYTANTQVHVALVSLMLSPPNYSQAAEMTEKLSRRAQEKKKEEGPAQYMLGPLSWRSCLVLIKYAAAQLKQPSMVTRVVAYMRSTFRDWSPTALNVFFRSSNRSGQYGYAQNADDALFGGTTIGRRGSSKDDLAAMPNMDSVIALIKHLQSTEQIDRLVKLTYALHPFLQSVRGENGDLRPEVHPLPEYVALVEALGSVGKVNLAQRVFGLALHAESSLVGQFRRENPGTREPQEVYLPLPIFTAMIRMFGAEAGRGRGENKQRRGWFVPAEDVHLSRTAAAESMILRIHKRVMTRYRAGAGQEGRIVPDERYLNAVIRGMRFRWHLEAEDAARPLPAQAKADLEKFLGNVAELGLTTPPGLVSKFKTGTIEGPTVFETTAPFGPAAPLPTSPELVKMALAAVEEERQAMLEDEFEELVTVPDTSERRRALQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1V489</accession>
    <name>K1V489_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V489"/>
    <dbReference type="STRING" id="1220162.K1V489"/>
    <dbReference type="eggNOG" id="ENOG502QQGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="InParanoid" id="K1V489"/>
    <dbReference type="OMA" id="KCTAPIS"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="51"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="442" mass="48594" checksum="110415A3EC73E4D8" modified="2012-11-28" version="1">MTAATARTTAPALGTTVPAISSTAKGDRAQPLKVNLQKKEKLKAALDEVMEKWAPHLPGVAFGITTGEGPIYAGYAGERVYGDPESGQVGEDTTYMLYSMSKLITSLAVLQQVESGVLSYDDPETIEKYAPELLKQKVLVSYSNSEPVFEERETPLTLRHLVTHTSGLVYWPFDAELKAYLETQRTPVMYSATVGDLEQPLRFQPGSKFAYGPGLDWAGIILERATGKNLEQLYREKIFDPLHISPDTTFEHVSDMLERWQRTVHRDPELKLEDPQRPTSGDLKQRKGGDGLWSTLPDYLGICAGVLASENPGGIISPPSQAQLFLDALPKATTPDGLEQAHQDLAGFLHHVGVNDLGPEDCGHSVAAMVIRRDAEGKRRAGSAAWIGAARTEFCIDPKAGLAFVAMTQIERPEDGPYDSPEPFDEFVREMEAKLYERLHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4K0</accession>
    <name>K1V4K0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4K0"/>
    <dbReference type="STRING" id="1220162.K1V4K0"/>
    <dbReference type="eggNOG" id="ENOG502SBFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1817156_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4K0"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052044">
        <property type="entry name" value="PKS_Associated_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36114">
        <property type="entry name" value="16.7 KDA PROTEIN IN WHIE LOCUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36114:SF1">
        <property type="entry name" value="16.7 KDA PROTEIN IN WHIE LOCUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="142" mass="15857" checksum="CD1631C506AF990F" modified="2012-11-28" version="1">MATLSMNTNSVFHVPPPTSSALLNNEPALQVNDQDLTIMTVKGQYYWHVHASSDEMFYVMDGDLTLQMRPVRQEGEPERAEDDADRTIQLTKGDIFVVPKNTEHRSGSKEGAQVMFLLRQGSLDFMSDDKVEEGGKITGHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V784</accession>
    <name>K1V784_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V784"/>
    <dbReference type="FunCoup" id="K1V784">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V784"/>
    <dbReference type="eggNOG" id="KOG3352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091071_2_0_1"/>
    <dbReference type="InParanoid" id="K1V784"/>
    <dbReference type="OMA" id="DHKPYWM"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="154" mass="16703" checksum="9B1FC67FFBDD3377" modified="2012-11-28" version="1">MVALLRSFRVAQAVARPALAARPAARAFSLSAIRLGGAQPPELIGPGVQPGQIPTDEQQATGIERFELMGKVQGVDVFDMKPLEADRIGTLADPIEVLSYYPVRQVGCTGFPADSHDTLWIDVTAEKKHARCTECGSVYTLKYEPHDTLSHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7F2</accession>
    <name>K1V7F2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7F2"/>
    <dbReference type="HOGENOM" id="CLU_987609_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7F2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="31449" checksum="51D4F820094E86E8" modified="2012-11-28" version="1">MFATHTLTCFLDDLDNRTPTSGMLTSVSAQENPPDTMSDPSSAGLAASSDSAATVNVDPTATTVFDVDGDPSTFPRVIKVYLALLATPPPESDDPTSRYRLPPPLKEDSASFRALVNKGLAHMKEKRSRGEGLNKRLSCRPLMPFLPKDLSQDELEEMFDERHLMGGPAHAIYTPFVHALESVFHSVVEWLYGSMWPPRIAFGLPPDDIDEDGAIVQIDMDAEYSDEDILASFGNMMLRNINFCRTMSASSREKHREYLPEWVQDNDLFANYQRRTGFSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7P1</accession>
    <name>K1V7P1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243950_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7P1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1609" mass="178885" checksum="618489F1A2AB5484" modified="2012-11-28" version="1">MPVLLPTDEGPLWYYISTAGVREIDRQIEQADETYDSVLSQLLLPHLEPRGPQRQLLLEEEKDLQARIPSSKHWDALDISLPVATCLLSGSYNWPFDLHQSKEALVWALRRKLESSTRRSLPTDRALARFPRKVESATGTTKSTTVFGPFNDIGLVVDLRSCDCLPPETARLSVARRSRWLHYILRQCGPLPVMHFPPLSHVVGTMVEHRDFTDEVAMDVYGVFDECNIEVLVQGGLLPAYGAGPLVKSKALTSVTNGAVRLNSLNGATVLFMACLLLQVEESVQKLLDMKVTGLVILRDMANHGLGWIIHSRDAKTIISRWIGSAEFYHMVPPPTPRLSLFLEAWMSRPDGPFSGDERVTPIRLFRYLSDLNPPEIDSDDFDPERSTERMYIRSGLFHGAAAGSAVALFLKSGAPWLRDNSPETYNDPVAAKVQAEKWVQNLVNRSRLCGGAKVLTEEVGLALKRYLSQELDGFAEDALDRLEELDKAICKSLDAFKSSPQGFDKDTFLQYFYRGFLVAVTGGRIRDEGAGPMAWISTDLRTQLQRSRHFLLGLPSFSALHSPSTAIQDKDGWLPRVLLVAAVCILTIGAILWPSKQTGFGMQPGVPQALAHDEARIGLGVMQASFKAGDAVHLKEGEQVYILEATFHDWYKIENLNGNIGSTMAYVSCVVSQPGDGVPWLTPCIRSIVEPRSQGNAGTVTRKAVHVPDVAKLELHLWQHTGPCAAVLVEFRASPLSPDCPSSVRDWTRLHSDSRGRNSSTRREHIPVYPTSAHGRRTFAPRTTAHIDYDYFEQRQAPATTRLPMGPSELVKWLGDMQPCKCQPLSAYLGEQSLDKLLEMIKDYRSTGNVPTRTCACSNPLSKLSQGAPHDPPSATCRLFPNGGDKAAWPFDIDEPKCTALDWIISRLREKQAMLEMEKAWVEYQHMEWHPSKAFEPSARFPGTRELYGLRNSSGNLFGPIKSRSLDVETVLVLKRCKLRASSDTPPSSWMSYLDRDVRNHPSSRPMLLTPAVGVMVSEPEFKDAEARSLFASLEVCKVKLLPVDSWENATFARPRGIGDRDPITLRGIRGPTILFLGCYVIGDRQSTDKLLLMRETGSIILHDLLDTDLVGIVEGRLNDLVKKTFAAAMECSADWSLHELCLRLALWFRVWMAEPKIVQLCKQSVQMPLDSLVQMINEFWKPEVGTCRLFAPDTAEGWEDTAEVTAIGVYHGCAVGAVVLAALKKIGKAEDRITSFEKTADLTHEWVTNAIAVLTAVFKAGAALKLDESKKRIVERLNRDLLKANHDEIFHLNKNLRRVRDNLTTVVASYAHRSILDGERLRAAFGQAFTAVVTQDLDVQVTDVITFFQNDDCKDDLPTLRHGSIQHFDAHFSRAIFEDLGSLRLLSYTARDFETIPRLRECLKSRPLVRNDGLKSVILQLKRQVEVQKQRQEEQRIAAKSIESTPAASKTGAPEPRSTAVSTLEYAQPPTRAMASLQSFVAFLKTSANVVNLHRVASTLSFATFLLAIWLSYSVASKGAAKFPQSFASWSHVSAGDDVILSVPATVAKVTNSYDVNASRRVLPGDTVERLTVPAKGWYMIKVQGSDEEGMIPAECISVTNQPVQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1V986</accession>
    <name>K1V986_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_08428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V986"/>
    <dbReference type="FunCoup" id="K1V986">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V986"/>
    <dbReference type="eggNOG" id="KOG0555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="InParanoid" id="K1V986"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="265"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC97270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="568" mass="63556" checksum="AD8A0B961CD074C3" modified="2012-11-28" version="1">MSDKPTLYVDEKKGSDSTGNGTEAAPFATPVAAYLSLNPSTESDKDPLSVVNILVRKPAEGDAPESWSELSGAGKKKLAKGVDVQRKKAAKLAADGERLEKERKEQEARDKKRREEAAQVKIAEPEGKADFVKAYQLPQEIGKRVRLRGWVHRLRTQKTNFFVILRDGSGPLAQVILTGDLIKTLDALDLTVESTIEVTGTVQKVKEGQTAPQGLEIIADWWKILGRAPGGDDAFEGRLTAETDASIRADLRHLELRGETATAVMRFRAAMLRAFREAFNQRRITEVTPPCMVQTSVEGGSTLFEFNYYGASAYLTQSSQLYLETVLPSLGDVYCIQESFRAEKSLTRRHLSEYTHLEAELAFIEFKDLLDHLEDMITSVVDTLMKDPVASEIIKTLNPNFVAPKKPFMRLDYRDAIKYLNEHGIKKEDGSDHVVGDDIAEAAERKMTDQIGQVIMLINFPKTLKSFYMKAIPGDGDFTESVDVLVPGVGEIVGGSMRIADYDELMAGYKREGIPPEPYYWFTDQRKYGTTEHGGYGLGVERLLAWFLNRFTVRECCLYPRYMGRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9B6</accession>
    <name>K1V9B6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_08395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9B6"/>
    <dbReference type="STRING" id="1220162.K1V9B6"/>
    <dbReference type="eggNOG" id="ENOG502RYE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419895_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9B6"/>
    <dbReference type="OMA" id="HAYSIER"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="194"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="653" mass="72685" checksum="A4317B7106134421" modified="2012-11-28" version="1">MPKKIGRPSVSCAECKRSKLRCERDRDKKDWPCKHLCPEGIVAARTSVRELREEIASLKRQLALAQSSPAGTKPMPPPTSCSPQDVVEGTVTVGQLSISHGGRSRFYPPTAAAHVLPDEGDEESKPSAAAGAGTTFPFFLQDRAAFLAEARAALPTYEEMQTLLEVYWEATCWRFIPVSRSYLDVVLLDVYGHSRQTLHRNDAAQLALVFAVSAVGSLFDERESPYSEKAHTFNRLSLACLGAADFLTNTSVASLATLHLHYSFTLNAGSRRTEELYAVVGLALRLAILAGFHRDGAWWKLPEREVNARRRVWWELLTLERINPHQFDTLRPSDEPNSSYLYWRWEWDDILHRLLTEYINSEDDSRLKLGDRAVREFWHRLPKALKFPGVTVYSDMDAVPLSSRRSEIPSEPATDRALLEQIRLSLHHNTGMLHLHRAGFSQALKDSPDEPLESPQVASVLVVINEACVNVIDIAAYVLEKVPKVSRHSVVVLDLYSSLVPLAAFVCRSPHSRLANECHHHLMRGVTLLEATTTKTPCDWYRVLCSRGQKLAAQATNRLMARWNGPNGSSSADGSTGPVENDEVDAMLGRTNRLHEAAPPVTIPTPAIEGDIAPDFDMWLSAFWPSVENVAPPTATALDGTEFSQLFVPMNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9B9</accession>
    <name>K1V9B9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9B9"/>
    <dbReference type="STRING" id="1220162.K1V9B9"/>
    <dbReference type="eggNOG" id="ENOG502S3XY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154205_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9B9"/>
    <dbReference type="OMA" id="LCAKQTE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="99" mass="10924" checksum="1FEC4668823C5D3C" modified="2012-11-28" version="1">MGITIIAKFTPKPGKENELRDALAEAAPIYRKDPGTLGWHVLSGKKDAKGSFVAVERYENAQAIQTHAANPVFGKKVHPLCAKQTELTFYDEIEDKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9W6</accession>
    <name>K1V9W6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9W6"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_3_1_1"/>
    <dbReference type="InParanoid" id="K1V9W6"/>
    <dbReference type="OMA" id="CETIKNT"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="89625" checksum="6D7BD8033AF69233" modified="2012-11-28" version="1">MPPKRAFYIAQDTPNVSPKLGPVDAFPLSRKGGLPIPSVGVPGRIRRPKKILYLFVIFFLLYWFGIRHGLGREKEERGPPTPLGFALKTGERHRPRTMVFLRNGIASLLPLRRGAPQPEHPVYELMERGEELWRKVRDRQSKTLKDAVKEYRRRYGIDPPAGFDEWFKWAQEHNVELVDEYDLMMRDVLAHHALKPETFIGRSEELSRNQSFAYTLHVTPEEVTITGERAGNARPKKLLSMVDSFKAALPKGFSLNITGSDHDVSGVVLGKDQRKRAMELVRKNKCAYDSCLTVTNSRLLRRGTQALPEPGALSRVGLVREYARFTASYSSNRAQKACPIDSPANRLNDPSEAPISEGQSFIHDHLSTMDFCEFPRLKVLHGALQYDREDRSPSLLKPWLVHSKLPGDASFLLPPIEGFTNLTEKDIPKLGTWDDKLDHRVHWRGSTTGGFSIQQDWRQSHRMRLHFMFNDKKGNESYWGETFRELIQPDGQGGYERVTRNMPVLAKAYGDVQLSGKPIQCSTDKMCEEIRDEVEFGSVLKPKDVWMFRYFLDVDGNGWSERFHRLLSSASPVMKMTIFADWHLPDYSDLYDILAFFIGPVSKDGTIDHSKGHDYLGKKIGEAGRDFSLNHWRWADMQAYIEYGQWIFLSSFLNVPCTQPTGPRSPAPASGLSPSRLARACARVSFRAGAWALRVAGVSAASVWCVSNTSPIVARALDIVTTSTQFSLVEAEEWSRDVNGSAVPGLPDFQPRLSRNGSSDGESSGAGVVTLRFGSCQPVCAQISSAHNQDAANADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAW1</accession>
    <name>K1VAW1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAW1"/>
    <dbReference type="HOGENOM" id="CLU_1094940_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAW1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="174"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="254" mass="27908" checksum="B4D5B188F8B21F3E" modified="2012-11-28" version="1">MAPLIPPNQPIDPMRIPIRVCAALATVPAPPVTCYITRSSEMIKLKSLSLSEASANRRLLYNGERVRHDDTLETLGIEDDDIRGGVTFELMAEHSADEGVKRGSCPCIFSSDHPLCRLKVQRSGRHLIRTGPQLEIPLSLTISSFLIVAIHSNSILTLTMPLIPNDEEINPRRIPVLCKVDHGLPTTCYVSRSAKLIMLKVELAEKMNVDPHAIRFLIDGETLSRESSLASLGFSDQKIKTGITIEVLIEQAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBN4</accession>
    <name>K1VBN4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome non-ATPase regulatory subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBN4"/>
    <dbReference type="FunCoup" id="K1VBN4">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBN4"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="InParanoid" id="K1VBN4"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="303"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="518" mass="59255" checksum="581E3D814922659B" modified="2012-11-28" version="1">MSFQRKQEKDFTPEVKELTPEVEKLASLNEAIDKISALEKQTRNASDMPSTAALLQLLVRLCWEQGDLEALNTQLHIMSKKHGQLKEAVVRMVDEAIPYLAELKKKKEAGAYKGKPDEWLRLLTTIRDITEGKIYLELQRARLTVMLAEYHEALSHTAPKASSSIKTDQEEEKAAAGDDDKEKKKEPVTAEDHLNAAADLMSDIQIETYSSMDKREKTEFILEQMRLESLRGNWSKVRVGSRKINRVYLKEPESSDLKLRYYDLIVQLALQDDNYLEVCNAYQAVWDTAEVKADAERELNVIENIIMYVVLAAYSNEQNDMLHKLYAMPELEKAPLHYQLLKCFVTRELMRWPGIEQLYGPALRKTPVFAPDSELGKKTGQSLQLQKAGTDPSQSPGDARWKQLHSRVIEHNIRVIEQYYSRITMARLCQLLDLGEAQAEKTLCKLINDKTVYGKIDRPKGVICFKKPMKTNQTLNVWSNDISKMLELVEKTSHLVSKEYAMHEANQAQAGKRKAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBQ0</accession>
    <name>K1VBQ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBQ0"/>
    <dbReference type="STRING" id="1220162.K1VBQ0"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_286663_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBQ0"/>
    <dbReference type="OMA" id="GVWVRKP"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="588"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="827"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="957" mass="102918" checksum="F04D941242DF0B4E" modified="2012-11-28" version="1">MPSSKSSLDKRDVYYRKGKSDGYRARSAYKLLHLDEEYDLFTGVNTAVDLCAAPGSWSQVLAAHLKPGRAGSDSRIVSIDLQPMAPLTGVTTMQTDITCPDTVPRVLEALGGRKADLVVCDGAPDGAYHTLKPALVPRVGQADPSVTGVHDLDAHLHAQLILAALTLSLTLMAPHATLIFKIFLSPLDPQAAILRSQLSTFFPGPPPGQDIDEDEDDMAGKPGYDRIGRRGGVWVRKPRSSRKGSGEAFIVCRNFDPTTVPLPSTISPQAYETFKRDIGSTLTLESLSALSSNGGIDPTWSERKRYVGGGDLNGSAPASGMHLPLPSHRRDSSLKSLDEIPSPIDTRASFMSSSPIREQLSEFEDFRRGVNMFRPVSPAPSDSWAEFQGLRSATGTPIASSLESNGSAAGSNSTPVRNKALNATPVSNSKTDAFFSTSTTSALPTPPSPLPKTTASSTSPTITTSPPSLPLPATPRTPALGRGVPPSMRARVVTTPGTPHTLDMNHLLPPVSPTNTQGFRSVTNPRVDLLNPPSPKSQFPRGNGPIAISRETHHDDPDAVPMKEGDVLVPSTDSAALPIRVPSNPGKWTLVEPLGEGAFSIVWSAVREDDNDAGTVAVKMIDRSACARNSRTTIAFCREVEVLRHLVHPGIVSYITHFSTDSHHCLVLEKLNGGELFHVVEDQALHKRMLLPGPNDPKGEGLVRRIFGELCRAVAWLHEVEVVHRDIKLENILFTVNPFQLAATSMGSVPLDQLPTPLIKLSDFGLSRFIATDSPLLSTRCGSEAYAAPEVVMGNLYDGRRTDAWALGVVLYALIAGELPFDDNSVASGRPRAGSTASTVSSTGGDQAAADRLSRRRVMHHIAKGEYGWREGVGSAGVREVVSRLLTRDTQRRARVSRLWELEWMQSGPGAVPPPQEPMVEPLPPRAPTPHVVVDQGVLVDHQGIGDLARTELTEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC46</accession>
    <name>K1VC46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC46"/>
    <dbReference type="HOGENOM" id="CLU_1078439_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC46"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="258" mass="29075" checksum="D0E46F2E0FD3B38C" modified="2012-11-28" version="1">MVNLDTLNFDQFTSSGQRPSQSSRPSQPYMTPPSEPTPLEACGSGSGSTSKSGSGSSSSTSLQRHDREFERPQISPPIERPILHTPAKYARVQHTVNTSADLAALFRSYIRALNMKSFSTLRLFLSPTCTCNGAKWNSDIIQDMIAPVSTRHSTGTIVMLVADISQRVVATRLQLQYQSNANIIEFDNLFYRYDDQWLIEEIRGNLPWNERVDHTIQEKRSRRRHRNLPSPQQSAHYIQHSPQTSPETNTYQALAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCB0</accession>
    <name>K1VCB0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCB0"/>
    <dbReference type="STRING" id="1220162.K1VCB0"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="InParanoid" id="K1VCB0"/>
    <dbReference type="OMA" id="CKGHDTA"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="4">
        <location>
            <begin position="12"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="329" mass="35706" checksum="6A2D9857D901D759" modified="2012-11-28" version="1">MTVEPSFKEHATLNGHSRSVTSLRFSPDGRTLVSAGADGFVHTWDAATGAHQRSLRAHRTGINELDLSPDGLYLATASDDTSVRVFSCDPVVSDRSEPLRTLTGHTAPVLCCAWGPRGNLIATGSFDESAIVWDVRRGTALRSFPAHAEAIWTIGWDSEGSLVLTGSADGLIRLWDITTAQCLRTLDNETNSPVGSARFTPSSFFILSATLSSTIRIYSLYNSKVLKTFRDADYVSERYPSPALVFAAHAEETMEVTEVTEVREEERAACVIAGSEKGCAVIWDLQDRRVLQTLKGHNTPVVAVAVDPSGKRVATGSIEPEATIKLWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCH9</accession>
    <name>K1VCH9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000388">
        <property type="protein sequence ID" value="EKC98510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCH9"/>
    <dbReference type="eggNOG" id="ENOG502RHEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076147_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCH9"/>
    <dbReference type="OMA" id="PWYEPQY"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="36557" checksum="1F7E6B5E4E20C431" modified="2012-11-28" version="1">MDVGVFNSTKPGDVPTQPGDANDLTWVNVGIGFLFVLFDALLSTVLGLGIGRGLVVAACRCIIQLTVMSKVLGTVFESNNIFAVIGIALLLENLAAIEGTFNKAKRRYTGMFPFILLSMMCGTIPISILGERFAMQQRPFWKPDQYIPILGMLLGNAISAIGVGINNVTTEFTVSRDKIETALAMGASRFEACRPIAVEALKLALLPTMNQMSIIGLISIPGMMTGAIVGGKSVEQAARLQMIIMFMISASSALSTLAALYFTLTTLVDASARIRTDRIDPRKPWMYRARDAFIEAVFGPIRGFFRGERGTEEERRGLLSGQNGENHDNNGNNGNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCS3</accession>
    <name>K1VCS3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCS3"/>
    <dbReference type="STRING" id="1220162.K1VCS3"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_3_1"/>
    <dbReference type="InParanoid" id="K1VCS3"/>
    <dbReference type="OMA" id="LTHFRYT"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="410"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="2">
        <location>
            <begin position="534"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="603" mass="67797" checksum="DD6B47E55748CCCD" modified="2012-11-28" version="1">MFCLTRDKPIRLPDDDADDLLDQIYADCEKEKGSLLADRPGEDEMQQRLADLRKQVTSAGLDWYEDEHQSEEVADSEKRREYISNFSGSAGTALIPSSKLDAKALLFVDSRYWVLAEKEVPKKGWEVKRVGASGGSGRSAVVGGWVDYVAELVTHVQRTLTSGLANSVNAQLAPGSTTLNAVKENLVDKIHTPPARSTEPLTEYPTSLSGESTSSKIARMRKVLAARARSDSWVYLLPSLPTIAWLLNYRCVGDIPYLPVAFAYAALTHDACVIFVDSEKLEDEALKKDWKQAGVETRDYGIDEVEKFVQTYVKKSGDDAKSKVRILASDESSWALIKGCKPTLPCPIQDAKCLKNETELENFRNAYLRDGRAMVRWFSFLEQKLVKEEKKIGEWTAAAVLLRYRRQEDMFADSGPQYLDATIDTTRTWFFGKQPDDYMKRAYTRVLQGHIAVATATFPLGADAGGLGMALTLATASDMLTSVPVGFTKGFSFKPGHVTSIEPGFYLEGRWGMRIESVYICKGVETKYEYNGPNWLSFEPVTRVPICTNLIDWSLMTKDEQRWVNAHNTMVQDALLPLLEDDLDKEAREWLKRVCKPKIIWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD97</accession>
    <name>K1VD97_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD97"/>
    <dbReference type="FunCoup" id="K1VD97">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VD97"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="K1VD97"/>
    <dbReference type="OMA" id="NCAYADI"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="34"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="370" mass="39253" checksum="973BB2B80732FF4D" modified="2012-11-28" version="1">MTASSNVVWPYLVVADEPIPKEQKAAVSHSAAAGTVIETVPVTQPNELKPGEALVKLLYSGVCGSSWHQASDHWDEGKGRVPRPLIAGDEGVGTIIAMNDPTTTLKLGQTVGIKFVAHTCNECPACLHGIEMVCPQAKYTGRSVNGTFQQYSLAWTSQLTPIPDMPLELAAPILCAGVTVWRALKDSTAHAGDWVAVAGAGGGLGSLAVQYAKYLGMRVVAIDNERKQAFCKEIGADAFVNYKDADFVQQVKKVADGLGVQASILCSNEPSSYLTGTHYLRPTGSAMIVGLPPTGSHVPVDCRNAVLGMHTVRGCFVGNRGDVIDALDVVARGKVVPKVTVKPFSAIQETYDCMKNGTLNGRVVVDLCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDP1</accession>
    <name>K1VDP1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDP1"/>
    <dbReference type="FunCoup" id="K1VDP1">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VDP1"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_1_3_1"/>
    <dbReference type="InParanoid" id="K1VDP1"/>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="402" mass="44199" checksum="66062CE2383BD067" modified="2012-11-28" version="1">MAEPSKDTQQPPADPANAPAASSSSAAADGSSSAPASGGKKQPMTVLVIGMAGSGKTTLMQRINSYLHTEQKPAYIVNLDPAVSHMGYSANIDIRDTVDYKEVMKQYNLGPNGGIMTALNLFTTKFDQVLGFVEKRAESVDYILVDTPGQIEIFTWSASGAIITDAIASSLPTCVAYVIDTPRTTAPATFMSNMLYACSILYKTRLPFILVFNKVDVEPCDFAKEWMADFEKFQAALEERGRDENGENYMNSLMSSMSLVLDEFYNNLRAVGVSAMTGEGMKELFEAVESCRKEYEEPELDRLKADKEAKAAAAKQGHLERMLKDMGVKDKPKNPFGPHVRNDRADALFDDEGGDADERDPEEEEAIRRQMELEEEAEHHMTLGAGDIVEDDIIQVDPQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDU5</accession>
    <name>K1VDU5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_08513</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="16"/>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDU5"/>
    <dbReference type="STRING" id="1220162.K1VDU5"/>
    <dbReference type="eggNOG" id="KOG4663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031114_1_1_1"/>
    <dbReference type="OMA" id="CCILGWI"/>
    <dbReference type="OrthoDB" id="244at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00290">
        <property type="entry name" value="cytochrome_b_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048260">
        <property type="entry name" value="Cytochrome_b_C_euk/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF16">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 C-terminal region profile" evidence="15">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="188" mass="21644" checksum="9813708E91ED91B0" modified="2012-11-28" version="1">MMTLHVNGSSNPLGVSSNVDRVPMHPYYMFKDLITIFLFFLVLAIIVFYLPNVMGHSDNYIPANPMQTPPSIVPEWYLLPYYAILRSIPNKLLGVVGMLASLLILLAMPVLDRSRIRGAQFRPLMKFSFWVFVTDFFFLMYIGSQHAEEPFVTLGSIRTAIYFGWFLILVPVIAFIENTLRDIRTREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDY7</accession>
    <name>K1VDY7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDY7"/>
    <dbReference type="HOGENOM" id="CLU_839886_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDY7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38167" checksum="60EC93C0F5395144" modified="2012-11-28" version="1">MVTIDYESFPHIIDLIWSHLDVEGLLAVRHSSSSWRTRANKILQRHMTLEVLFGKKEFALKLSLKHEEGHASTTGSLSHVRLPHYYVDYSMADIKDEDLGRLPSGVAGDILSGALHNLAVLDVIYHENDIEKWLPEMLKLFGPDTVVYFLNMGNMLQLEFMEAPDTLVLNLDCVGPKASPLELQFQRLLDPGDVAGTDITFILDHGALEGNRPNAVWVENLEMTLAPIWTVATVTLVGLERFFRKAWVFDIFKQDSYATAANTFAYMGEVYNPTAEADMLKRFAVAVKHKELRKCGAVRLLTHEEYEAVLGHDKYMIYTSYEQQSQISPVEHPQSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDZ0</accession>
    <name>K1VDZ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDZ0"/>
    <dbReference type="HOGENOM" id="CLU_804571_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDZ0"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41814" checksum="C192B93D8BBB529D" modified="2012-11-28" version="1">MATIDHLFFPHIIDIIWLYLDYEGQIAARAACKDWRDRADARLNHIVISCSERPRFPHIFDISTRDLTQPFSSRAWLGSMFHWHNIRDHEWECGCNRRQCPQLVLHESERLAVHLERTGLSTTAAVDLVGFGLDWPRVPPDLSCNSLLRTVLVESDCTIRCYGALPDLSDFKDCCYAYNHDFLDCPPSLVDVCMMTLEPDMPIDTLSSTELSMRVDVQVANYLCLTDPTASYPNLSTVWSEYRDDEVCPVTVIFHNGMPRHDHTPPSKQPDLVAAYADLIHGGNEVIIVGLEEFLDSNDIPEYIETVEREVLRGRRIYDYEEEDDVWWVPEKSCLDNLFFMTHEEYRDHVGEDMYRIHAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE23</accession>
    <name>K1VE23_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE23"/>
    <dbReference type="HOGENOM" id="CLU_094332_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE23"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852083" evidence="3">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="258" mass="26693" checksum="BCAA96AA98C7D0DD" modified="2012-11-28" version="1">MLELALVVTALVQPAAAGMAVAESAKRTFTFGLKVVFAVFTSGTYGNLGFLEPMHIGESEDDSCLAAGSYGVSMLGAGGGSSWAPVETPSEVWAEARGAVAGSVLGAAALIALLVWYFLRCVRAVRGNYAIDLQDEGEVEPLSAMEALVTPLAMSRRSTSIGKKDMSVPRLLSEGYTAAQLSGVGHLDAGEAGPSTHTWEPEDDAAYADTVLKKRPSNLRSGPVRDSSRNQTASAEGEVFSNTGAQCGEKATSLGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VED7</accession>
    <name>K1VED7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Bromodomain and PHD finger-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_03322</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000288">
        <property type="protein sequence ID" value="EKD02370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VED7"/>
    <dbReference type="STRING" id="1220162.K1VED7"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003589_0_0_1"/>
    <dbReference type="InParanoid" id="K1VED7"/>
    <dbReference type="OMA" id="FEIIMDK"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="181"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="506"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="959"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="656"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="862"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD02370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1090" mass="121677" checksum="3D9D842E6B7B9B7F" modified="2012-11-28" version="1">MSTMSSASGEKTYEIPTVSFRVITDDKSLLAPAGVHSEQARSYGYNDFSDFERPEHYIRYIEPIESELAAQVEYDMDEQDQEWLDTVNAERKKDQSGPVSYEVFEIIMDKLEKEWFTLPETNMPDGDSKCAICDDGEGENSNAIVFCDGCNLAVHQDCYGVPYIPEGQWLCRKCTVSPENPVSCLFCPNEGGAFKQTTTGHWAHLLCAIWIPELGVGNAIYMEPVEGVDMVPKSRWKLHCSLCKERVGACIQCENKSCFTAFHVTCARQAGLLMSMKLMGADGQLKAYCEKHLPSYHETSESDVFEDEEEEEEVVTPPPRKRGRPRKNSIRNTSGGQPKRPRGRPPKHRKEEEEQAVVVADKKRKVTTKSARAHAKSYRPGPPIVPRMIVNKLLDYIGKISIRKKQPFVERLCRYWSLKREARRGAPLLKRLHLEPWTATTESKEQTDAEKAKNLEFLGMLRNDLEKVRMLAELVRKREKEKLRQAQVIKEVVDSFIFPHYETLRSTMDRGELFLQPVTLEEAPDYYDVIKEPISWTQIDAKLKSVKYLNVADFKYNKSETSFHRTASRIKKNAAPLLDALNSIPAAGQLMPPAPEEDHARPRSLRDRPRGGARHAALDLRFRGREGAASAPFSQEAEDNVCRRAHKKFEQAEERYKERLSMGGGSTRVSRAAAAATIPESPPPTTGRRKASEETSETSRRSQPGVVGVTSVPAMSERERRQAEKNLDLIAESLDSKDEYERFNIGWILPEGSKRRRPAPVTVPPPPKRSTSRAASSVSGASERNKRQRTSTPIDAPASKKRKGAEPEPNKEEEKAEEEDVDAEGEDEELTPVPDSAVTPNFPRSSLSPPPADADGEADDAASDKTAVEQPSKSKSEKDATPVPEKATKDEPMDVDADADGDTKNDPKTPKTPAGQEGSTAESTPAKDRRKSLVAPKPALPADGSDPYPPGTQEKLTSVWAKVTSYPYFPGVVIDPRADPSIVPPSVLALEAEETKSGRAWLVRFHDKQGSWGWMHPERIEALGQDDEVDKMYLAGKERSRNKGFKSSHLKASCKAAYQKAMEAQDPTRTESSGNKEKEAEAKSEKQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEM1</accession>
    <name>K1VEM1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="5" type="ORF">A1Q2_08233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VEM1">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEM1"/>
    <dbReference type="eggNOG" id="KOG1839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="InParanoid" id="K1VEM1"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="OrthoDB" id="771227at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="406"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="733"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1325"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1406"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1325"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1373"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1415"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1425" mass="155288" checksum="D9B6AC25404146C1" modified="2012-11-28" version="1">MSANEAKPEAVPEAVPETVAQEAPAEGAEGEAAEEQPQLPPVYVRLPKPNSSRTLPKATGTENYSSLKLYSQPSETVQDLKLAVSEWIGGYWLGPYSLRLPGQPGEALSQSKDGVDVHAGEKLSEWLEIGDVFAHVPEEGDRSLEVVKEPYTEATARAAVVRLLDYIEPSGTSVHTLSTPIGVAPGATIFESVRDGKVTAQTGGLAAPVYEEVEAQVPTGGKKGKGAKKETIKIKKEIPAENLHAFSDWKEEWQSLPLSKLPVAQAPLEVLPCLRSIQLSPFNPPPAHLRQKGHQLYLQVSILEGDVYTLVCNSRGWYVSKSNVNHFDPAPRAAADGSIPAPTHSLIDLLHTLSPLFSERIFALPSLSSKPPALDPLSTVAIPQAEPAYPWLISAPKPDTVPDVLRTQLAYLHTGATVPEALDSSRDWNEEIQGVKELPHSTMQERVFRERMAQKTWSEFTQASLRAIQAVSRGDVIPLNSNEPSRSHMWLASNIFVTKAIDSIDAYAHLGGDAAAHVSHAKDAEGVKLLNRLDVDGAYLLGHTVIDWQGDRWVCQSVLPGIFSRREPAPEAAAEEPAEGEDKKEDWVKVEGEGADASNPLIIYGVDSEQTGTIHWDEATHKIMEQIAAQQRLAPHKVKSGDDEREFYASAEVKGLRGSDGRRYLLDLPRLNPVDIEWLEKDYNGKLAGPEGAEGDAPTYPHRMALLRTELVELFWESELKRWARKVAEEQAAKKKAEESDKPAAEGAAEGAEGEEKKDEQPKETEEPAIDPETIASLKDFELRFNPDAFVDSLPEEGATTFGPAKYADESDPSIKAVRDASVFLRTIAVPAVALDVLTGAATGIMDGISLTRHLHARGINMRYLGHLAATIDTFSKGKDGEKRESSGYLKSLKDIVQHEMVFRASKHVLRRLVRDLLPEQVPAAVAHFLNVLLGTEVNPAPKAVYERSDVGPAKEPEYVSLTPEQLRAELIEEIETRFRWKLDESFLTQGLRKPQLLRELASRFAFQLAQRDYAFTSEDAAAEPEAPKAAKGKKNAKAAASAIKRSTTFEPADILTLVPVIRSTAPAVTVAEEIFEAGRATINRGQVELGLEFMLEGIQLFESIHTVIHPEVAAAYNQYASTLHQLARIKIQQMAAQENADPEAPLGLDIATGLRLQRQAVIIAERTLGVYHPDTLAYYFQLAMLENLEGNSKASLTYFRHILLLWGVIYGGQHPEIATIISNAGIVLQALNEHSASVVLLKQSAARARAAFGDKHTQYAAALHQLTQAHFLGGDFPAALEASEAAHAIFKDAYGEDNAQTKEVGKNAELLRAVIDNVERQKQAQDAMRAQQQQRLAQATAAARSSASARKTAGSAAGQRIASGAKLPGQLAQTAQQAQAQTQSKSGKKSRIGERGEEAIDDLVNYIQGNAGKNGKKGKKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEP0</accession>
    <name>K1VEP0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEP0"/>
    <dbReference type="STRING" id="1220162.K1VEP0"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458694_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEP0"/>
    <dbReference type="OMA" id="THGECKS"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="557" mass="58065" checksum="17E6B6741E795B04" modified="2012-11-28" version="1">MSYPPAEDRAYQGYYGRPSSAHGTQQPPDAPSPQRLHSAGSGATYPRNAPPHSPYTPHEVAPPGSSHGLPPPVTPVNPSSAPYPQQQQTYPAMPPNQSNQENTSPNNSRPGTADYTPDGAPIVPVGISGGKMFRCRGFGECNKVFTRSEHLARHVRKHTGERPFPCHCGKAFSRLDNLRQHAATVHADQTQLNEAMLAQLAQVHATLSQRANREQRRRGEVVEVPKNAVERPRGERGPKGGPPNAAAIPPGGHAYPGNGAPGYNQPPHQWGPPPADHGRPRTSGSWVEYPGYVAAPGSVGSDQHPPGTAGSVGYGDDAGPSRRPMSATTEHAYPAYYEQGPPGSAHGRPATAAPPGTSGSDDSAQVVPPYRPLSSSGAAGGHYAESEPPSSAHGPPPHSPMYPPNGAVPGSQAAYPSADPNLYPQGTVPPEGSHPYPPGHDQGGYGPPPPGSSGSYYYPGQQGGHYYGQQSPAAQAQATFSSVPPGTTPTQPYPPGYNGQAGDSPFQYKAPGPSPPTYRSPRGQLVSVPAIAGPRVLAPIRSVGVVLSSVSWLGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEX8</accession>
    <name>K1VEX8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEX8"/>
    <dbReference type="STRING" id="1220162.K1VEX8"/>
    <dbReference type="eggNOG" id="ENOG502SCKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065849_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEX8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="354" mass="37919" checksum="757E0AE9DAC82C3B" modified="2012-11-28" version="1">MLNDVVAFFAALRPYAPILVILFGPRLLSLVRSFRTSSPADPLSPTLLLLLALQTIYAAYSILRPPYDVFVSHSLPTLSPSRNLAEQVLRAAGYTSLPEPGQGDPIADLLARLTTKSGRETYVRWGHAVAVNCGWCRAPLDWAVASLPGILGPYALQAALIGAMGWQWLAGRLAGRRAARYRLLAGGAVVAACAGELAARWWTDLRVQNGQIFHLSSALHAARNVVLLLITAFYVLAPVRTAPAVLTQEQLKATLEGTAHTNRLQYAVRGAVVRDPHLLKTATQGEVAFARAEDKAFADSADELRQSGYSRAANKAGARAWLDSVWVKSPSSPTPRSRGASPASAGPANEAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF45</accession>
    <name>K1VF45_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_06217</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF45"/>
    <dbReference type="FunCoup" id="K1VF45">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VF45"/>
    <dbReference type="eggNOG" id="KOG2327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014815_3_0_1"/>
    <dbReference type="InParanoid" id="K1VF45"/>
    <dbReference type="OMA" id="GSENCHQ"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="18">
        <location>
            <begin position="340"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC99485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="682" mass="75461" checksum="C9F3C77625BCBEAD" modified="2012-11-28" version="1">MSSYYPASQKDAPSWDSFDTIEDETLDVAEDHILFVIDASESMHKPLPDEENEAGIIRGKSPLHQALESVCNIERNKVTTGPSDSVGLVFYNVDDPTSGASQGKAGSGILKFQQLRQISAEDIKRIYRIVQQANAQYDEQTESDEETVEPAILRELFPPRPANDEVNIANVFTDCNHVFRDGKLVGNKRIFLITDDDEPQGSLGNRQPARTTYNVRLPLPSLQLTSGSPHFGCECQHLLCWPTGKALRSPDLLEHEQFAREIPAASDGLSELADIISELVIRQAPKRKQFSIPLKFGGRDGDIEIGVSGWNKGQPKLVHMQGETVEEVQTKTEYTAAETGGELGAHEITLAYQFGKEATIPNVLEKNYWEKGEDGPAALSQMDVDGSADQQPKVVARTRTMSIADLAEIRILGFQSPERCRLEDNVAHAYFIYPDETNYTGSTRTFTALLNSCLKLNRHALAIARLRANSPPEFVLLIPQAETFAKGGGQEDPPGFHVIRLPFVDDIRDPPRGMTDNIVATDEEVMAMEKIIRRLRFKSGKYASDAYQNPALQYHQRQLEALAFEEDFDTAMFEDVALPKYAGVHKQAGKLMAEWKRLVDEDDRALENLTVKSGTKRGAAAPATAAYAVADVVDAFKAGKLERELTPELSPPEGLPLTKLLKKDLIDLVKPHLQGAGKKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFJ5</accession>
    <name>K1VFJ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFJ5"/>
    <dbReference type="STRING" id="1220162.K1VFJ5"/>
    <dbReference type="eggNOG" id="KOG0966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_481618_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFJ5"/>
    <dbReference type="OrthoDB" id="2594834at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="566" mass="62495" checksum="833B77913CB5CBDB" modified="2012-11-28" version="1">MGDPPMSKRRDQKEKTISYTPEEIFGAWISKQAQPLVPGTTKKLFRLLFPHEGARRRYDIKETRLASLLEQTLGIKGLTRWDAVSLNGVRKTGCLGEEPNGNSTMTIGEVDALLDQLAAGSSWSQLSQIPSDRPTQMTILQRLFRDSGMSPYALSVLTQIILRDLRPLLFPLPLRYVGRPELLIRETISSAPNLLTVESAMFRWDTTMAKLYREGKGNIDWASSRPLLTVEIPKARGAGSSTNIALQGFYDGATPMAPIVWAETKYDGYRMQIHVALSPQPKITIFSKSKRESTQERLNAHSTRPAHPRAFAIASVILEAEVVPFNEGSREGARGPGIEEFWHLHSAGVVHENSGREADRHRHRHLCLAFFDVLYANGESLLLHTYEQRRAALESIIHPIPGFALQRVFDKAVEQYEGVQLTLQSRPSHSFIKHYNDTIDLVVIGAGWDPERARQLRETAAAASSARTPVTKLAQDTSAAVAPNAPSGVEPAAEPASILAEPGAYPHIRSSRQGNRRRVAPYAAALLSRTPDEAAPSHSPARTPSLTEDPRGTHAGVWDERASSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG06</accession>
    <name>K1VG06_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG06"/>
    <dbReference type="eggNOG" id="ENOG502RB92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234098_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG06"/>
    <dbReference type="OMA" id="HWREFAL"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1183"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2066"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
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        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="331"/>
            <end position="340"/>
        </location>
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            <begin position="361"/>
            <end position="382"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="412"/>
            <end position="422"/>
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            <begin position="423"/>
            <end position="466"/>
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        <location>
            <begin position="581"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
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        </location>
    </feature>
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        <location>
            <begin position="675"/>
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        </location>
    </feature>
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        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
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        <location>
            <begin position="791"/>
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        </location>
    </feature>
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        <location>
            <begin position="875"/>
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        <location>
            <begin position="885"/>
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            <begin position="901"/>
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        <location>
            <begin position="1198"/>
            <end position="1216"/>
        </location>
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        <location>
            <begin position="1285"/>
            <end position="1297"/>
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        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
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        <location>
            <begin position="1350"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2126" mass="227306" checksum="D6C26A72EC6730A9" modified="2012-11-28" version="1">MSTHHRQKRGRRGGPGHRPDHRPPGLVSGLAEQPGQPLPSPRVSMSFNTQPGHPFAPPPFRPGAHTRQESSFQSHAFPLPGMYPWSTPPIPSTPVKPSPLGNNSTTASASAPKFGPPQYQPQGNGNEPRGSVHQRSPPTHSQELPTKRQRHRQVENGIGLGRPSRLSISVTASQAAKAARSATAPGGSAVPVRQPFGPSNPSDGPPPFANGARRTWALDPSARATLGHFPHSQSVSNPGGAFFGPRKTHASHLSRSHERTPSIPHRVGPPPKAILGGPGGKTFEELRVPPPSRPAPAPSSPTAAASSDLPRPSSPSAAPNGDTISSPPKPTAKEPFEVKHGGTTVRVALPSSAVYDPPDTPLEDVAEDSEEADGAEPAEDETTITQDGESDGKESGAASDTVATADEKSGEDGEPGQETETGEEAKDPGSDDNAKEVTETTETIEKPVRPSKPPRKEAFPWPERKVASPKSIPLPPSPLDEELELSDIENWVAHDTPHGSIDITSSWNGKAVKVSMPPALRAKSMSPGSTEPSALYEDAVDLVELALDVEMREATPPESDEAAEPADPGTARSLPTHLRSESMQSNATATGSDADSNAMPSQAQRRHTNLSLSSNPFLQRSLGGILRGDGRENRSNAPSPVSAAFPQRGELPDWYHDPTMQNTPSPSQSNFIGSQGFPQDGFPQQGFLPDWPTDMLPKAEVVGEKEASPEPDASEEGEGWGTPQSTPGKEHGHSATKTETEISESLWPSTSASKADEEPSASPTSIASTADDIVVSVQVTSGPPKEPSANTDDRTVTEEKDLIKLDSDTPSSDTTTRERPRPKVATGFLQRQLQSIMRSDKSKAKPPAAPTAPAPAQEAKASTSPEVPPTPPPTQEYNAGLEQTSAKEEHEKIDDRQGSDLDSEDNEGGDESYSLDGSDGDEDFVDSPSSPFKPSGGQDGETNGDDAPRRNNPSFKSLSPIGKLKPSASVFVPRAVVTSPPRMMPKVEAPQPEQRPPSVTSSAFTFGYPSTVEHRKLSLASTASPRNPSKVLASLPSLQPSAPAFKPTAPAFQPSAPVFQPGAPAFQPSAPVFQPGAPVFQPAGSGFGASNAQTAGTGGALGLFTFTHNLRPTAAEFRPNGVRLGASPLRQNASLKPHPPELDLSKADPTSKPFELGSAFFPSNEGKLEFGNGEVSLLMREKRPVKIERPEPPAALLPRRDPASPRQLSQRERDSMSEAEAVSDEDRESPRRRKHTAKRSSQNSYLPKAANFPKTPASPEKKDDVNIYPSQPVKAPARAEPDTPSAPTHQKRPSLNPTAKPFVFGQGSFSSPASTQPPDGNGFSGASKRAGAGVQVADASRFRSWVFPTSASNSSAAKSTQKRRHSDSDHSRSSSGGYDDRSSAADMHGLDTAAVEAMQRDMDGGDWSDWPGSPPRMSQLRPVQTGESVEFPLRRDSGQAIEVIKPTNDTSSSNSPLSTPSDVAIEQGLAAEILDKLDSLEQQLASVKEENERLLEEAFDRVDVAHESSAVRALNALRENVAAVLTSHSTLLKEIQTAINDNLIADEGSSRDSSQSSVAEGDTTLVNTNTLNTTAIQELLTSLQAGQKAMMDKISLSAQSATIAELREVKAALLDLRAREAEADDAKAKEIAELKAILKEERSRRELADSKAAVLKSQVETLRQRRDSTEDAWRTSLLTEVTTASAKVKIIQASETEAQQELVSLRQELSKQSELLKAMKEETAKQRHDDATLLQKEMASFHSSFFERLDSLTISGDPKRVQVLEAELSAAKEEEETCTLRVELAEAKASIALEREKGLRAGENHATEARTLDLQLKAEKARGSYLESKVQKTTAELAALTQNLDVWRSAALEQRLRAEQGAVHIAAMQQENFHWREFALGADRHRLEQWLSTRPFEGLDHLTVAKAAPSVVSSDTPYAKGAGKTALPAKAGVAPPVPSYPESRKASIALEREKGLRAGENHATEARTLDLQLKAEKARGSYLESKVQKTTAELAALTQNLDVWRSAALEQRLRAEQGAVHIAAMQQENFHWREFALGADRHRLEQWLSTRPFEGLDHLTVAKAAPSVVSSDTPTPRAPAKTALPAKAGVAPPVPSKQDGPPVPPKGAVTPKATPRAAPRIVEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG98</accession>
    <name>K1VG98_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03105.1"/>
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    <dbReference type="InParanoid" id="K1VG98"/>
    <dbReference type="Proteomes" id="UP000006757">
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            <end position="165"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="84"/>
            <end position="111"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="18282" checksum="0729B78976389EB3" modified="2012-11-28" version="1">MFDEAGRQRSEDQTSSLEQFKRSWQLTYQYKATGRYRGESWKLRTLQLMEDIEQDAGTPVDPSIMDAKIDGTPRPSLLPYNGDSGANSTTTPTGITPVQSFRQSQGQTYAQPLSSPAPPPPLAPTGFVYALVPVPNSGQSPSPPPMFYSPNMYQPQQPVQQPHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGN0</accession>
    <name>K1VGN0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGN0"/>
    <dbReference type="eggNOG" id="ENOG502RDDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719994_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGN0"/>
    <dbReference type="OMA" id="KDAYPYS"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="384" mass="41752" checksum="2A03C5FC91362E69" modified="2012-11-28" version="1">MAHPLTQHPPNMIGFGAPATMSPLSFGFGQPGMTLGSPVRPGAFNGLHHGFGVTSPGLTSPGFGSAGPSSPLKRASPPRTSSMPIPTLSNKRTRRASSVSSSSSPVGSPSLSSRRMDDDDRRERKIAGSKAIKRIRKETEESSTTSDASLPSTSHLPILMDIINEDPSLAPRILRRIPQPPLDNCLEQLERIVAKIGRAAGSWDVQEGYVATRRWNRVEEQVDNFTKTASTYLKFFSQPSSTQEPVEPNTLYHLLHALTAHALQILPIVPDGPPTSARPFLELANLVLTTWGTWLTRISDEVNNRGGMFPHSMAQSWADGLDQLAREPPQTTQAAAPSVSWAMPMSMPAPPSTRENPLVIGFRHALQPIRDRFMNELGWLAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGS4</accession>
    <name>K1VGS4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Carbohydrate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07290</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGS4"/>
    <dbReference type="STRING" id="1220162.K1VGS4"/>
    <dbReference type="eggNOG" id="ENOG502S2CW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_2_1"/>
    <dbReference type="InParanoid" id="K1VGS4"/>
    <dbReference type="OMA" id="CIYDRAD"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854138" evidence="13">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="14">
        <location>
            <begin position="33"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="27569" checksum="A54C40D3338B0D1C" modified="2012-11-28" version="1">MLVKLALAVLATLSAAAPCPEGVQVVENCKQSGTVAWTFDDGPYMWESDIMNKFESKGSKATFFLNGNNYGCIYDRADQVKEMFNRGHTLGSHTWSHAHLKGKSYDYISKELEKVETAFIKILGVKPLYFRPPYGEYDDTVLKVLSDRGYKKLFMWTHDTEDANGKGADFGRNVIGKVRDQSPKPALILSHSTQDVTHSQVVPWGLDQLTGRGYRVVAVDTCMGDEGEWPYQWVGNPGQRDGSWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH26</accession>
    <name>K1VH26_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar transmembrane protein, Tms1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000250">
        <property type="protein sequence ID" value="EKD03425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH26"/>
    <dbReference type="FunCoup" id="K1VH26">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH26"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029574_2_0_1"/>
    <dbReference type="InParanoid" id="K1VH26"/>
    <dbReference type="OMA" id="DKHCNPL"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="530" mass="57980" checksum="A979023EA6A2D4C0" modified="2012-11-28" version="1">MLRRPRPHPPPTSPHRLQQRYITMGALLSIPIIGGAGAIGSSILSCFAVCMGGTAASAFCKSCNCNSSIATRVGYGLIFALAAMMAYLMRTDIMIKQLERLSWDWIKMDCSGGKCYGLLAAHRFLFALTLFHIILSILLIGVRSTKAKRAAIQNGWWGLKIIAYLALCFIAFLIPNEFFMFYGAWIVPLGAFVFILIGLVLLVDFAHTWSETCLDNWERTDSNLWQFILVGSTFGLYAATLVVTIVLFVFFSGGGCGLNTFFVTANLVMTVVVTILAISGPVQEANPKSGLTQASMVAAYCTYLTSSAVVNHTDDGHCNPIQKATSGTKTTTVILGALFTFLAIAYSTTRAATQSKALVGKGHRAGAIALPEDDDAEVRLVTNQPKGRRDEMRYQAILAAVNAGSLPASVLDEPEDDEDEIDGIVGEDRDDERAGTKYNYSWFHVIFAIAAMYTAGLLTDWQVVSTEPVAHPSDPKEQFASVFENKDQDVYIGRSEATMWMRIVSSWICYALYSWSLVAPLVMPDRFGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI40</accession>
    <name>K1VI40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_01798</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VI40">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VI40"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="InParanoid" id="K1VI40"/>
    <dbReference type="OMA" id="NERQMTR"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Region D6 of dynein motor"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA_lid_11_sf"/>
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        <property type="entry name" value="DYNC2H1-like_lid"/>
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        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
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        <property type="entry name" value="Dynein_AAA1S"/>
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        <property type="entry name" value="Dynein_AAA5_ext"/>
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        <property type="entry name" value="Dynein_C_barrel"/>
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        <property type="entry name" value="Dynein_HC_stalk"/>
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        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
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    </dbReference>
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        <property type="entry name" value="AAA_6"/>
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        <property type="entry name" value="MT"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1858"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2515"/>
            <end position="2665"/>
        </location>
    </feature>
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        <location>
            <begin position="2857"/>
            <end position="3023"/>
        </location>
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        <location>
            <begin position="3119"/>
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    </feature>
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        <location>
            <begin position="3337"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD03785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="4509" mass="509858" checksum="F45200F4871C4F4B" modified="2012-11-28" version="1">[encoded data, 4509 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIG4</accession>
    <name>K1VIG4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coagulation factor 5/8 type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIG4"/>
    <dbReference type="HOGENOM" id="CLU_1533656_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIG4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="175" mass="19251" checksum="6AA080AB65AA802C" modified="2012-11-28" version="1">MVDAKTATLGNVLGKTFRAYCSFYCSQSNSEFVNIAIDTDTPYEPVDKNAEYTVSSAAADVGILGKDKVKFTPTGDGAYTVETKEGILGIDETEQARAWAQQPRAFDKSEADKAGKQWWIIPSRSHEDNKETGTVRLVNRWSGLVYSGKDGLVPARSWEHGDLKPEAQELTLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIX1</accession>
    <name>K1VIX1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIX1"/>
    <dbReference type="FunCoup" id="K1VIX1">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIX1"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054987_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIX1"/>
    <dbReference type="OMA" id="TEVMGAR"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger CCHC-type-containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="328" mass="35307" checksum="324AA15902B48F0D" modified="2012-11-28" version="1">MARFTNIGMPKKRFVASAAEEREAATDEPRQQDNEAGPSKGKRKGWGRDPDIATERSEERRQKRADLRTNQTTCFACRGIGHAARDCPNILLAASGANGSAALLEADEMAKRQAELLEGEGKVKSGKRDKKAKGGDVVGGKCYRTSQLPCGREQLTPRCNSDKHSLSRCPKPMDPENPTPFATCFVCLGTGHLSGACPQNPRGVYVNGGACKVCGSVKHRANDCPDDKRPKPEPGAMRGNLAVGTGANAGADEDDFMVERRIQHREQRREKAEKAAQKKPYSRPKHEPAKNGMRGPAKQPGEEGAYAPAPVAAPVAAAPKKKAKVVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJB2</accession>
    <name>K1VJB2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJB2"/>
    <dbReference type="HOGENOM" id="CLU_2607725_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJB2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="79" mass="8448" checksum="38D7C7C8FBC9C043" modified="2012-11-28" version="1">MHIPTPEQLSLVSGILEALRPAPHKKGVVKAAEEALPTQDEICAAGQKCRDSLQLVAQLRQSGAEVGPHVEDNQMHCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJV8</accession>
    <name>K1VJV8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJV8"/>
    <dbReference type="STRING" id="1220162.K1VJV8"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="K1VJV8"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="533" mass="58084" checksum="91E3BB62FB1380B1" modified="2012-11-28" version="1">MSGIIGAEQFNREFPATKQHAVDDVHGGTIQGTVTAVYEVGCFFGAMGAFIIGERMGRRRMMLLGGLIMIIGTIITVTAFGPGDSSGRGNVGGFVQFIIGRVVTGLGNGANTATVPSWIAETSKAHNRGFLICMEASTVAVGTVIAYWLDFGLSYVDTSVSWRFPIAFQIFFALILMGGVLVLPESPRWLLRHGYDAEATRVLAALENRTTDDEVAVEAKTRLAHSLEAQENMSTGARALFIQGKNQNMTRMLVGASTQLFQQIGGCNAVIYYSTILFRNQIGLEGQLPLILGGVLSVVYMIFALMSFLLVEKVGRRKLFFIGTFGQAGSMFITWACLLAGGPENAKGAAVGLFLFIAFFGATWLPLPWLYPAELNSMPVRTHANAVSTMTNWICNFLVVQVLPTMTASINSWTFFLFAMANVIFLPFIYFFYPETSGRSLEEFDVLYAHSHAVGRRPTVVAKELPKLTDHQIEVMTDRYDLHNNRNTGKDVENGVDTSLPPATGEKHVYDSADDTVPNTAAGSSEDLAHNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLI7</accession>
    <name>K1VLI7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F1F0-ATPsyn F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000347">
        <property type="protein sequence ID" value="EKD00137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLI7"/>
    <dbReference type="FunCoup" id="K1VLI7">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLI7"/>
    <dbReference type="eggNOG" id="ENOG502S739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152700_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLI7"/>
    <dbReference type="OMA" id="TIDYQMH"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="98" mass="10535" checksum="F98E1613D11AEA64" modified="2012-11-28" version="1">MFASAVRRNALKGLIPPKIATPSAVSSGGTSARTEEVVKFYSKLPKGPGKPSGGIRGRYFEGPNASGKPILATILGLFLIGYTIDYQMHLKHHKHHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLP0</accession>
    <name>K1VLP0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLP0"/>
    <dbReference type="STRING" id="1220162.K1VLP0"/>
    <dbReference type="eggNOG" id="ENOG502SAMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151409_2_1_1"/>
    <dbReference type="InParanoid" id="K1VLP0"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="99" mass="11144" checksum="878FBDA852C17876" modified="2012-11-28" version="1">MWATTLRQASAARSKAAGGLSLQHAYRKAVRATRHPETRRETLDWLRADLERLRFETDLEKLKSNLSSFNKNLKIMVPSLGLGGLTPDSGAKLIGQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLQ9</accession>
    <name>K1VLQ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000145">
        <property type="protein sequence ID" value="EKD05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLQ9"/>
    <dbReference type="FunCoup" id="K1VLQ9">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLQ9"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_3_1"/>
    <dbReference type="InParanoid" id="K1VLQ9"/>
    <dbReference type="OMA" id="AEQCPFH"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="561"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="832"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1107" mass="117455" checksum="DD9E52F33DF25334" modified="2012-11-28" version="1">MPVAQFGRPAPVPAQAVPSANDDAEASPELWAQLRPDGKSDRVAVAVEWPKERRLAGACAPNLVVWVRKEHLLPSCLPTPASVLVHAHTPVSLSLVVLQPCGEYEIDASDLEQFYPKSDLPNGTADDDDDCDDYSGGYYGAPTSAVRFADTSKAGTIVRSRDVLSLGGGRSVRVPMTEPVAQGLVDSDTRVVLATRPEIPEEPEESGSVAPSHRSLVEEFDPDAFLSSSLALSLERDEGENEGLEAEVSTNSGSLTPRPGDRPLSPVAAPDDVLQLDAEEGGMAFVAVPSAGPSGVAGEEDVCYAGVWALGRAGVFEGDWVLLKAANGARSRLCRVVAWERLDSEDAALPPNALLVPPSVQRALFPSPSARAEVIVSPTPFGAREPTLPTARSMTLARVATAEGMDKRYERSWIVGLKRFFAGGRLMVRRGDVISVPVWVGRPLPEGEDVDDSYTGRPTALAYFVVTAMNFEPLSSLEEDFSCSVASKARAGELGCWADAGPGGDTALVLAGAERARVTGRGTDLVWHGLPAPPPPFAPSSASTLRDLVRSAFSSLSLAKFPLSVLVKGARGAGKRSLVHAVGDELGLSIVEVPCYDIVGDTPQVTEGTLRAKLDKARACAPAILLLTHLEAFAPASGGASAPKPPPAVKVLEDILKSARQFGAENGVPLVLAATTSDSDKVPRDMLAVFKHEIAIAAPNATEREAILTTALGDTPLAPDVSVSHVAAQAAALSAGDLVSLVERARDVALKRAASSLSPSDALLAGVQLTAADLTAALGDARSSYADSIGAPKIPNVSWDDVGGLAAVKQDILDTVQLPLEHPELFGDGMKKRSGILLYGPPGTGKTLLAKAVATSCAANFLSVKGPELLNMYIGESEANVRRVFEKARDASPCVVFMDELDSVAPKRGQQGDSGGVMDRIVSQLLAELDGMSGGRGQVIVMAATNRPDLLDPALLRPGRFDRMLYLSVPETHKAQADVLRALTRKFTLDPDLNLDELSERLPFTYTGADLYALCADAMLRAMTRAAEAVDAHVAHLDNTPMPRSFPKPLTPQYYLASMAQPEELEVIVREDDFVEALEKLQPSVSREEMEHYRQVQQQFKSFEIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLS4</accession>
    <name>K1VLS4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLS4"/>
    <dbReference type="HOGENOM" id="CLU_467072_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLS4"/>
    <dbReference type="OrthoDB" id="2597004at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="66811" checksum="29BB7339952E41C0" modified="2012-11-28" version="1">MRPTSKLPHAFYPHIIETIVFYTDYKTKLRCRATCRALRQFTDRLLIADAVCVTMGDFKPAVKPFSGQTYPFFAFEGDRPAQIRRIRAYSGNLSVEDVNASCINPIISQIEPLGAVSLYHQSCFANYQLPKFLTPSSLGIYPPWHCTCDETHNLQPAFHHAADTVHIEYSDPQARYCEVTNDIVYEKGRQDIVIGEETVTNCHLLKHALNDQVTRLDIIIPFPLSESSFKHLARYLFPNGASITTNAELQVWIDLSVTGMTGNRIHDNQTANVFIALFFMTLLLLIPLQLLVYSLIPVPQPYTSKVHYDSFPHIVEYIVAQADYQTKLQCRATCRALRKYTDTLLLPRAVTVDNVLAGSRSTGLLFGTLASPFDGTEYPFFKQEGDLPAQRCKLRSFQAQLIIRNVEARTLTPLLGRLQRVLIDQHFRGPNYQLLEFDAPSFLAMEVDRQCSCGNRDLHPSFHHDALNVNVSLKGDEGSQSQDGDSPAETEILPGSASQCHLLQHVLHGHIRQLQLFIHLFITEESIEYLPAYMFPWADQVNMNPALVCYIKIPTRSPNPLQFLQRVRAAFAKHLRVNSNRIFVEQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLU0</accession>
    <name>K1VLU0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLU0"/>
    <dbReference type="eggNOG" id="ENOG502S8AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_977229_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLU0"/>
    <dbReference type="OMA" id="FNDAMEV"/>
    <dbReference type="OrthoDB" id="5569309at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="285" mass="30843" checksum="1399F4EE730A55C6" modified="2012-11-28" version="1">MSQFSGSLLSKRKADLVEIAEALGITETEATMPELRDKIQGSLNDNAEQLKDDPRFSGLYKGRGRFHIHPQLTPRRTSESDSPQPEVKTPRRPRKSVNKAVANLMDAANIPLPDSPITKENITEAGERALDAANKALSVVDTDAEEVAGRLKRLSGQLVKATEKQRGVAEKYIREARDPHGLLLAALALEAASVYNHVAPFDHRTDLRDCSSSPCAVDYPAHPPEPTVDPLTFALFRAALLLVPLTGAAPSSFNDAMEVIGNVYARALGAGLTTALIVAERLTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM11</accession>
    <name>K1VM11_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM11"/>
    <dbReference type="HOGENOM" id="CLU_772053_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM11"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="359" mass="38684" checksum="B6FD402D07599F14" modified="2012-11-28" version="1">MPTLLESPFLSLGMIDTLLRTTSDPAQRVQLLSARVHRLQLEPAINPSSSHSSLSSHSASHGHGHHAGHPHQHGSHPYAHAAQAHGHLHQLSGLAALAAHQPRSTKGPGNAYLDEYGHATVPPHGLEHGHERPAQVYGDGFGFELDLSRSTSRATSRANSRANSRAPSPVRSSGGNTRAGSPTLKSPVPKRPSRPDPTPLLTTRAQLVKAYLSLTPPDYHAAESEALIVLAECRRIVKWEKARIRRSEQDHAKPSSSSSSPKQAPKAVSAEGAQEDKEERKEESKEDKPIRKNSSDADLASSPVAPPVHVSPAWYPEVLKIQLETTRHEATINEGLGRESRAARAAQLADELAAELSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMF4</accession>
    <name>K1VMF4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF788-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMF4"/>
    <dbReference type="STRING" id="1220162.K1VMF4"/>
    <dbReference type="eggNOG" id="KOG3269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094308_2_1_1"/>
    <dbReference type="InParanoid" id="K1VMF4"/>
    <dbReference type="OMA" id="YIATFFP"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21674" checksum="8E63486212D86F78" modified="2012-11-28" version="1">MQANASSKRISAANKAALRNLARNLYLINALALGVRWVKSNVYGRPFLPSGFVLFLQVATFVATIAVWRWFIAIGTPHTDAKGNVKVAEDLAGGGVIELAWDMIYLTWICTLGSALIAPWFWYLFLLIPAFGAWKIYGVAKPFLGMFLPGIFGPKGPKPAAQEQAQAAQPAESKKQAKLRARMERGDKRVQQVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMT1</accession>
    <name>K1VMT1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000335">
        <property type="protein sequence ID" value="EKD00667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMT1"/>
    <dbReference type="STRING" id="1220162.K1VMT1"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005470_1_0_1"/>
    <dbReference type="InParanoid" id="K1VMT1"/>
    <dbReference type="OMA" id="CWAEGVY"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="49"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="12">
        <location>
            <begin position="408"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="705" mass="78888" checksum="42A8A0B05AF3CC89" modified="2012-11-28" version="1">MAATVESSEPPATEHAATPSSDPTVNGSAPRASTSSAHSLDLPSLVPLSHDHALLSSATFDVDAFLLSRIHIPLDELRGELRSYLGVLREELVQLINDDYEEFISLGTGMRGESDRLKRLQKPLEMLRGEVEVVRDVLASHQDAVQEKLDERATLREEKALLELLQRLFETLNRAESLDTASDDAERPKAVARLAGEYTQLVYLRNKVQREGCKLAEVAEPRIDKLRSRLNNDLSTLLTTALEAKDEAHIRQCLRTYDVIEAWEDAESVVRDDVETWCRSNIRAAALSDPVTSPDSPVPSARRLKPSTPLAVLYNRVLDQVEVYQPLIKMAQALSAHFDFFSRVLWPEISKSVVDNLGSVIFAAGRPDELHKHYTATHQFLTHFESYAPSIDAVIAVRESPEYSAFERRWQLPVYFQLRWKEIVTAFDSALNSTTGTATSPWHLPQSQAAWTAFQRCWARDIFLPELTHRFWRLSLQIVSRYGLWLSNQLINFKEDEDDATLRFAASAISDSDLLLEKIATLPELVELGVDLPLSLSTTHYAERIVLILQKRCAEPLKLVRSVASQFRASGSKSSGPPAASYFVPQLLKPVHAFFDGRPALKAKYQAAWAGQVAEHVMSNYAQILAQVRKTEDLLRRHRKTRKGGFSLFGSQNAAQDDGADDERFKAQMLADVEGLAADAKSLGVTVDNMASWAELKDVVQRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN99</accession>
    <name>K1VN99_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adrenoleukodystrophy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN99"/>
    <dbReference type="STRING" id="1220162.K1VN99"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_5_0_1"/>
    <dbReference type="InParanoid" id="K1VN99"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="101"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="690" mass="74406" checksum="DCCF46FE66A9DD8C" modified="2012-11-28" version="1">MSQVASKLIPPGTKAAAQARLSQLTQSYLANRTHVQRFLTAGFVLYCIAGSVVNLSGKGVKISTSGRGKKGGAARKGAAGGKGKKKVSVSDPLFQQRLKKLLRIVIPGIRSREAAMLALHSCFLLGRTALSLYVADLDGRIVSALVTAQPRLFLMNLARWCAVAIPATYTNSMLEYLQSELADAQAVALCARRVSGHEGAGRRGRQAVLQARKPGRPDQERGSVHDGGYFTTCRLVPGEDAYEDMDEGEVPIISHPSLPVPQVDESPSSNAMCISKDGDGHPDEGQHSTPSSGTHSLDQPSASTGSTSMGGSSSSDNLSLQEALSSSNPMGSQPSEISTPGTTVSGTTSEDTPHGKLWGAIEGLGTTQNTPQEGSENAETVNPPTLAVDFFRPLLGTLLLSQNPAIADPVRNGIVSVIARLRGKSPTVETWGAKAEEGEQESTQTYLSQSGHHCHVSMPFTHDARDLVEQELLWGIVLGMGTLSITYIPQRPYLCTGTLRDQIIYPDNHAQMLAKGVTDADLQGMLEVVDIGNIVEREGGWGAVREWRDALSGGDKQRIAMARLFYHRPKYAILDECTSAVTLEIEKAMYDHATNLGITLMTVSHRPSLWKYHKLVLQYDGQGGYVFTELDAEQRLKLQEEKQDLEHRLLQVPKLKARLEELRHIKRQRDGGRDGGAGQVEGVVVEAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNN0</accession>
    <name>K1VNN0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNN0"/>
    <dbReference type="HOGENOM" id="CLU_1225526_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNN0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="25141" checksum="6F63DC6D724F5A20" modified="2012-11-28" version="1">MSPIDLLKTTTTLYVALPPAPTGSEASATLSAAMAEASDEGAAAAIESVPEVIPLREAMRSAIESYMPHGFTVLFFLFLAWVFYRNTSITLELAYVDGLRYLHQRIDELHQRLDHDNRQWAQRLEVEPIATFERQQHDTPFGWNLNCRLSSRQQPPPPPPSHAQTCTREQEMRQTSSASASRPQSNRETSSRSHDGQTSQPSNTEHQSSGDRQPGTGEEPDAPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP94</accession>
    <name>K1VP94_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP94"/>
    <dbReference type="HOGENOM" id="CLU_1788173_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP94"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="145" mass="13640" checksum="F516CD0C35742A69" modified="2012-11-28" version="1">MSSVSVSTNSSPASSVQPSASASISAGSNQSQGGGNQTVSGSNADSSSAVNRTGNDNSNSNSTVSGGGGNSTANGNSTSGGGNNNDTGKASPTEAPEPKVNKTAVPLPTTAPPSGPAPGSAMALNLSPRLGLTALLVGLALSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP97</accession>
    <name>K1VP97_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear mRNA splicing, via spliceosome-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP97"/>
    <dbReference type="STRING" id="1220162.K1VP97"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1092170_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP97"/>
    <dbReference type="OMA" id="ENMDPRI"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000502">
        <property type="entry name" value="Pre-mRNA-splicing factor cwc2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="216" mass="23999" checksum="FEB66FF9BCE406CA" modified="2012-11-28" version="1">MGGVGSFNRSNRTLYIGKMHESPDKDQSKETLLRHFGEWGKIDKWNILYNRGIAFVSYTHEANAQFAKEAMQCQSMDMDEILNVRWATEDPNPGGKAAEDKRIAQEGRKVIASKLDDNLIEASQTLRALEDGDIDDLYEIEQQPEVSEDTRPAKRSKAEDGKPAPKAGLLGGDTLENIKYYAELARKQAEEDRTRKVPAKGGMGLLSGYGSGDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPE6</accession>
    <name>K1VPE6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPE6"/>
    <dbReference type="STRING" id="1220162.K1VPE6"/>
    <dbReference type="eggNOG" id="ENOG502SK3R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657540_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPE6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="43173" checksum="53676A54086473E3" modified="2012-11-28" version="1">MAELVFRGSLSCDPLSAVPLETPVRIERVILSPESDGFTADVLYNLSSTDPADALERLSTATTRLLVNAPARLNIEVYGCPSDAAVLPEKMTAKFQLPEVGELLASLPDTRGLPSLRLLAKTGRFPLAEALESPHLDSLAEIGGDAVLRAVLGLDGKQTLDFKPAEALRALPRLDTPRAAPFPATQSPLALALSLMRAQAVSTHAHAPAALATIIRLLSPLASQPETAGALSRVLPEMAARAITAGEDVKLDTPPEHARAVLATLAPLLAGEAWGKSTAPAATKLARAYSPDPAFWQPAAADPGLGISGIQLSVSASGEGERLSRALDTGTGHGLRPTAADTLAALAPELVASLGTAVQPPLGLPSTIAAGVGNASDYAGKVYSAHEFRRERDTASGLGLGAAGVGRKASRHVDEFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPG8</accession>
    <name>K1VPG8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPG8"/>
    <dbReference type="HOGENOM" id="CLU_2943466_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPG8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="60" mass="6938" checksum="88BC8447A5349845" modified="2012-11-28" version="1">MPSWYKDYEPQRKGCLTPSFNRTLRVEPLKRAIANRAPTALQEEMRQGSDPVQEAVTEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPZ4</accession>
    <name>K1VPZ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPZ4"/>
    <dbReference type="STRING" id="1220162.K1VPZ4"/>
    <dbReference type="eggNOG" id="KOG3789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847826_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPZ4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35307" checksum="569D1A1E13DCA577" modified="2012-11-28" version="1">MMVDIFQYSNMYTTTPSFARLTADEAVQSECGIYVTRQGSPVPDWPILASLYAKLRPGTTLHKWCEVKPHHGAGIDPRRFVTFGVIKGFLRRVHRWPIVLDRSVQLFLPSSQPTSTLGVPDHPRRRVGFHRGGDSGFSRHGGHGGRHHDGQERLGGYLERAERGALDSTITLRSESNSSIPPSVSPGSPAQASQRGGSHISQSAYQQNQFGKSAGGDTHPSFSSRRGVRSGVSGMSGGMSGGMSGGVSGMSAGLNSGIDRGSGAGSVVRREHRQAEREDKLLSLLDGHHHADEIQTTFGLSWTQLEKVLGLEDMKGGIGRKGVAVVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ42</accession>
    <name>K1VQ42_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ42"/>
    <dbReference type="STRING" id="1220162.K1VQ42"/>
    <dbReference type="eggNOG" id="ENOG502RZS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665958_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ42"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="413" mass="44914" checksum="017E85043B915A00" modified="2012-11-28" version="1">MPRRRRVVVREDRELPPIPLQRQRARSFKFFLYVFPTALVTIFFYFFALDSRSPGLLIGSLICASGLLLSLRAHEEFPFNRRKVIKLRAWANIQMHVREGLGVAQVAITGNPALNHLPTTPSLHNIPMSPLQENDALPDESVVASDPGETDLRTEEFLGLLAGFPIALQHHLLGTRALPQPPLCDLLPADYLSSLKRTDSRVRFAEEHSGPSGSGNPIGKSTKPNGDANTNGAAPGTVTHSDEESDGKEEPTGKEEAPAPVKKSNLHAPYPAHLPLSLLRLLEAYVAGFSQRPAEKGGWTPLQTERAIDAIKGLNAALTEAESIYNGEFHLPLIVKLTAAPDPVVSLTLCAYLFVLSILCFIALYMPPLVSLMTFGLIAAAFPPAFSRATTGPSPSCELPHVVTANSQPRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQH5</accession>
    <name>K1VQH5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQH5"/>
    <dbReference type="STRING" id="1220162.K1VQH5"/>
    <dbReference type="HOGENOM" id="CLU_3070363_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQH5"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="53" mass="5698" checksum="74C997E6E3949BC1" modified="2012-11-28" version="1">MANFKGQTSDLAPFLGASMVAKPIFNETQGKHSISKADYNAHGPSAIYGVWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQJ0</accession>
    <name>K1VQJ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQJ0"/>
    <dbReference type="STRING" id="1220162.K1VQJ0"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQJ0"/>
    <dbReference type="OMA" id="CGQSGYY"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="506" mass="53899" checksum="B654A43425052279" modified="2012-11-28" version="1">MTVAQKTSTKLDVPGHGAVEVPTGLFINNEWVPAKDNATFEVVNPATGKKLVDISHASDEDVDNAVKAARDAFENTWGTNVDAGERIALINKLADLLERDTKIVAALESLDSGKGVRMAATSDVPESIGCLRYYAGLADKVAGQTINHFGPDRFAYTLQQPIGVCGQIIPWNYPLMMLAWKIAPALAAGCTIVMKPSELTPLTALYICNLAKEAGFPPGVLNMVPGLGKTTGNAISHHMDIDKIAFTGSVPTGRAISVAAAESNLKKVTLELGGKSPALIFEGSDLQQAANWISLGIYFNSGQDCCASSRVYVQDSVHDEFVKLLAANAKAAAIGKPEDDATSFGPLISEGQRDKVLKYVDSAKQEGANITTGGKTWGNEGYFVEPTVITDIGQDMKCVREEIFGPVVVVGKFSDEKEAIKLANDTTYGLAGAVFSKDASQVQRVAQAIKAGTIWINNYGILSSRVPFGGFKQSGIGRELGTAGIDAYMQTKSVHQNLGEQLEWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS25</accession>
    <name>K1VS25_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS25"/>
    <dbReference type="HOGENOM" id="CLU_1788174_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS25"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="173" mass="19815" checksum="CC70CE7C1F6F167C" modified="2012-11-28" version="1">MAPRIRLGYNAKPWHDLRDIKAYNEEFFSPEFQSHYPDMLYLCSFTPEGQWIYRDCKKEDEWVIYAAATPPYNEVMCEKIVRDDYEEPRGCTADTAYFEADHHFEPVENAKEIRESLPPDATLQDAMQALWRTCKGCAKYVKDGNSSADKDSSSAVAKDAASNPKTNHTPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS88</accession>
    <name>K1VS88_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS88"/>
    <dbReference type="STRING" id="1220162.K1VS88"/>
    <dbReference type="HOGENOM" id="CLU_1107761_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS88"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="251" mass="27088" checksum="9167D27F339D3FEA" modified="2012-11-28" version="1">MSGAKVPHDEVWPIYERLIDFEAVMPFNFKCRASVVAGGNPENTAPAVDPENAPLTLQQHALASAMSAVILSILRPYTDQATAFSALLRRCNMMIATSLSLFSVMPEVAKTHWFMRYYATIAAVTLTSVAITAPKSPLARATMIQVQAVCDLLQNLGDPAFVLLDHLRQLAIANVYGAPQARLVLEVGEKSRGRKGVGPWTSVFGIPSRTKSSPGDAAFDALRAAWPADCGHDRTGIDWPTIAKSLAIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSX8</accession>
    <name>K1VSX8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clathrin heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSX8"/>
    <dbReference type="STRING" id="1220162.K1VSX8"/>
    <dbReference type="eggNOG" id="KOG0985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719990_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSX8"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012331">
        <property type="entry name" value="Clathrin_H-chain_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="384" mass="43146" checksum="24D902D312E0D909" modified="2012-11-28" version="1">MDKVLEEGELQVNNLERGHQLASLSREIATLVAEMTVDPATKRKHTVGMVEKAMTEIGYSTRADKTAKAQALDLIRQLSQPDSVLPVERVRMRVRITMPAKDAKRIKEKLMELVEETEEEEMDAEWETTIETFKSLPNVPGSLSPILQYFGILLEKGELNKYESLELARPVIQQGKKQLLEKWLKENKLECSEELGDMVRTVDMNLALSVYLRANVPNKVVACFAELNQFDKIVLYSKKVGYTPDYAQLLQHLVRINPDKGAEFATQLQRLLKGPGSDVVLANYARLRSHVHKLEEDAFGGVTNLWFVSFVGVSPEAQGKGVGRVLCDAAARLVRDKADETGVRTLALVAISEDAMRFYKRLGFEERGYVEFKVGDAVPPEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTL6</accession>
    <name>K1VTL6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTL6"/>
    <dbReference type="HOGENOM" id="CLU_991066_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTL6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768209" evidence="1">
        <location>
            <begin position="16"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="281" mass="30031" checksum="29FA9E52CABC6C6E" modified="2012-11-28" version="1">MLITVFIAVVSVVLGAPLEEALDTRDGAEYTTEVMIHGDTPLSIGDISAFELVREALDELCTGQDCDTTRWSTPKTTMKGYTNSASELKSYNVSISANAIFPVLKGADGKLDGGELARTSLKTAMVEAVRLGEQRKWLEYSVYPDISGGIAGMNMLHSKWDWFGSIHPQYALYRSQTGDGSQAGHIRIDFHVEVLGPKADFCSVLSNIVGSLASGIGLLPMAGPILGFLGSIAARGAGSCAKSKRDGEYGAYVPNFTNNSYTQSLLDGEKWWSETSAALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTW0</accession>
    <name>K1VTW0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000348">
        <property type="protein sequence ID" value="EKD00118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTW0"/>
    <dbReference type="HOGENOM" id="CLU_1176139_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTW0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="26439" checksum="65316D5C66AD286C" modified="2012-11-28" version="1">MDSQLEHGTLPGQKISEKSSTTPIARACCVRPVLRYPRRCTTQYQLRASEVSPVVQHTPSRTENSPGVRTSFPETASRRRRSAFCVHTFPVSSPSYPRSPLSAQHTRAPFAHLALDDVPRVLSPPTSCVHEGLVEEYITRSPRPLSLSNHNHFDSNSPPLQLSQLQPLSPRLNSKINKMSTNQQEEPTVYYYCSDCGSAVYVDYAQGRDKGDLCIVCVYSPKDDESSDEEDEKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUK5</accession>
    <name>K1VUK5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000265">
        <property type="protein sequence ID" value="EKD03192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUK5"/>
    <dbReference type="HOGENOM" id="CLU_928093_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUK5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="273" mass="29936" checksum="6E70CB67AFF6171E" modified="2012-11-28" version="1">MSRTRIQPKRGNGPPQAQVSKAVGRKRAAEPAVGVTQPAKKVKTQRASSQANEDHAPTAEELMAAAAAAITEFDQVIALTTTTIEKNNALLVSLSARIQQAEDEKKLNSESSPEALEQASRIPSHTSATASTSSPSSSSPWAATTLASLQTLKRKPNREYREILETFLDGRRTKGTYIRFIHSKSSLRRVAFVADQRAEDVPDISLPLPAEEIGKRQRFHGHDSCYRLLNVTKLPDGSIVCDPHLVKMVVSTEGGRERFSYGIEKLEPDNQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUX6</accession>
    <name>K1VUX6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Short chain 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_02422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUX6"/>
    <dbReference type="STRING" id="1220162.K1VUX6"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="InParanoid" id="K1VUX6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="12">
        <location>
            <begin position="34"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="198"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="313" mass="34034" checksum="20C466845BBBB58B" modified="2012-11-28" version="1">MSATKRLQTIQSHLSTAPVSGSGSGIAKPEIKVVAVYGAGLMGAGIAQVAAFAGYDGLAIIRKSSERIAKHMAPEGTDTAPIIDGIVKAIKTTTDRAEAVKDADLVIEAIIEDLAIKQDFFKYLDTVANGLLIKEINAKCPQERKKRFGGLHFFNPVPVMRLVEVIRTEDTLPEVDDALYAFGKSLKKKPIRAKDTPGFIVNRLLMPLNREAIRMVERGDATFQDVDTAMKLGAGHPMGPFELFDYVGLANKADTNLLVGKGWVKRAEQGYIPKAYVEPQGTLIQDLVAQGKLGRKSGEGFYKYEQKGKKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV09</accession>
    <name>K1VV09_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV09"/>
    <dbReference type="eggNOG" id="ENOG502RB9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806955_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV09"/>
    <dbReference type="OrthoDB" id="2562897at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="344" mass="38132" checksum="0F5638930F946BDC" modified="2012-11-28" version="1">MDRPPGIHHVPMTFANNRRLAVPQRPQAGHAGPSHSGGPPLSPRASNTAAPSYTQYMATPSPPPLSPSPLGSPMSRQSSIQSGSLGVLSTPAIEADNPHVASDEQVDLGSPERAPPPKLSQGEPPTAPLWAAIERLSKQCDEHQLRFRASKHRIFSEFPQILSRLAELDNRAEVSCYTDERQADNQQCTAELFAAINESQPELKARLEKVLQRRRENVDEMRVRTTPWVDFLPDDEEDDLELLSAKEGATAMVRRESGKIERVKGANATNVDSDALAMIERWAEEVKMHLADEIGRLRTQLGEEKRRAYILYRLLGLMLFCVFMLGVFYLIAKAGERGRALTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV47</accession>
    <name>K1VV47_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV47"/>
    <dbReference type="STRING" id="1220162.K1VV47"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282581_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV47"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="76"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121726" checksum="8ABB66183BAFC9B5" modified="2012-11-28" version="1">MTDVEIHRTDSKGSAQELEKPRIEEEELAALPTAQAKIAQQNAALYLEALERYGADGSGLDPVAEKKLKRKLDLRIIPALAVCYFFYYVDKTTLSYAAIYGIKDDINMGSTGYSWLSSIFYFGWLAWAIPSNLIMQRSPPAYYLAFNIFWWGALLMCQAAATNFAGLAALRVLSGAMEAIADPAFMLITSQYYTRSEQPSRISAWYCANGIGVAGGGLIGYGIGNIKGALNSWRYEFLIVGAFCSAWAIVLALVLPNSPAKFKGFSHEEKLMMIARIAKNQTGVEQRKINWKQVREAYTDYKTWMFFTLGLVANIPNGIISNFSTLVIKGLGFDELKTCLLGIPQGALVVIWIGLGAFVNARLPKNSRTIVCMLFMIPTIAGALGFLLSPEKAYVGRLICFYLTGSYQASFVISLSLITSNTGGQSKKMIVSGMIWFGACIGNIVGPFFCKESQKPRYPLGIGALLVANCLELALFFVFRYAFIIENRKKRKQREEAQANGTQQIAADTAFADMTDKENVNIRALSSAAEAAQAGDGTKLQALLASPGYWRDVLAFSRDFRTFQGGEVGQAAADTFPKAQPHNFQIKAPAPLLESPFPDVSWVRMHFGFDTTVGPCSGIARLVYERGEWKAYTLYTLLEEVAGHPQQVGRNRPRGQHNAAEPHDERRAREAEFADSDPDVLVVGAGHNGLACAAVLRSFGVNALVVDRFSRVGDNWRKRYASLSLHDPVWTDHMPLMPYPPNWPVWMQAGKLANWLEAYAEAQECNVWLESTVDPSRTVWLPEEGKWQVTVLRGPQRTPRTMKVGHVVMATGLGGGKPKLPPKVPGQDAWEGTIVHSSAHAGGRQWARKRALVVGACTSGHDISVDLSHCGADTTMLQRSPTFIMTIKNGLPLLDGGLFTEEVLETLSMDNADRIADSLPKQVGKLFHQRIVDHLAEADKEILDGLKKAGFRTWKGPEGTGWLFLAYERAGGYYFTAGENSGSQKIIKGDIKVRQGEIASFGPGKKVVFKDGSEDEYDLVVFATGYTGIQDSTREVLGDQAASQMGKVWGLDNELEVNGVARPAGIPHVFFTIGNFMMSRWFSRRIALQIVAEREGKWGDVYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV73</accession>
    <name>K1VV73_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000337">
        <property type="protein sequence ID" value="EKD00638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV73"/>
    <dbReference type="STRING" id="1220162.K1VV73"/>
    <dbReference type="eggNOG" id="KOG4469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005984_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV73"/>
    <dbReference type="OMA" id="VLGHDLM"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="95424" checksum="5DF636D1250B733C" modified="2012-11-28" version="1">MFSRGSSTPPIDLDDAHLEVTVTPSASAFYAGETFSAVITLRNTRIPPHLRSLDGTVQPSTSRPHPTHLLPLQKRSSGGAASPASPGTPTFSPDGKWRGEHARRPSGLGHTRRSQSLALDKSVSSQEMIWALGGGDRSEPSTPLPPPLPTRRTPTIPLSHPHARKVSVASTAAFNSPNPDESRFPSSTPPLQSDSETSTELRSGSSERLDSLKGPSPLDVSRSSMRLSPSPTPSLPYVAEESPTRSTPRTSPVKDPGRLFTPDLPTPAGSPGVPSPASMHSTLSNGSDRRRQRPHHARSPTYHHTAFGNIDAPPLHPQLRTKPVSQVGTTTVLWAHARLIARFAPSTSYIPPDPLLPLRSRLLHQPIGSGSLIPSTEQDKSTLGSRWALNFGTGTIGHQTRPSLTGSLFGLAKSMVGGAAGGSLEEERRRVWNTHDLPVLETTRSLMGVDIKLGEGETKESFKGKAMRFSYELVISLNVSLPGGGKRQRTKEISVPVRIWPNVSLPHPLSTYNILDPVIQTKEEGVIVEQTPDAKTPLSRRRNTGPKELPQPKPDSLAAYARQLMDTVEPAADGHIPVPPSPSKPFNPLTPKTSTRTNKSPTKADFFLSPEPERTQVRPRSTSIVAGDDELVEETQKCGEVVQILSRHSPKASFDITKDGEVVAVLTLIKTAYRLGETVTGVVTFNEPKATGRVIKFSAYLETHELIPETLLPPSASEAGRVKQPDLRRVHAEFRSSYAVHTSRTPFSLDIPSDATPAFGLVAGSEGRHGGLEWRLKLAFLVASPEEFDADEYSEEDYAALEALESVDAPPPPKPIAEPEVLSLVPVEGDCDNGPYTAAPGLAPYFVRDGEWSESETQTVQCEVPIQVLAGNTAFVVRPSNFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVA9</accession>
    <name>K1VVA9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVA9"/>
    <dbReference type="STRING" id="1220162.K1VVA9"/>
    <dbReference type="eggNOG" id="KOG2859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891943_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVA9"/>
    <dbReference type="OMA" id="PERWHEE"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="312" mass="33514" checksum="40BF1DD5B71C552C" modified="2012-11-28" version="1">MVTTQSMLAEIGSGTASELTPDSPPGPTFIQSLDEVLVASRPHPGGSTLQRGDLVEVIGPSGSGKTALCVFLLMTTLLPATMTVGGVEVTIDGRGKKAAILSPPSHASVRPALRRAMQRHIEDCLQQVPHTAADVDIVIDAALANLTVVKPQPRWTSWAVALRKIATKKDLEMVVCDGFGDGYWVERWEHEERRAGNTMRDAWDALTHLRQTVGAVVVVTVQGLKPHLPAPYPSVFDGQRWGITFQLTLLGRKRSLQFPAETTAVEALRARHLGQTQEYIGVLRIPGGGGEAGTPRGARWTFVIDDAGLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVE4</accession>
    <name>K1VVE4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 39 (Zinc transporter), member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVE4"/>
    <dbReference type="FunCoup" id="K1VVE4">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVE4"/>
    <dbReference type="eggNOG" id="KOG2693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVE4"/>
    <dbReference type="OMA" id="GMMYIVS"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="31779" checksum="F232ABFBD47E6D23" modified="2012-11-28" version="1">MAVPADLDPASLNTMIAFATGGLLGDVFLHLVPHAFFGEGEHGDRTVVVDEKRNIVIGGAIFAGFAAFFVLDKTMRVLNAQAGNEGGHHHHGHGHSHGAVEGNSTAVKKSESELRKRKVKGEDGIEVEVVTEKEEKEVNPSLKLSAYLNLFGDFTHNITDGLAMAASFYSSPQLGAVTTIATFCHEIPHESGFTKYQAMGSQFFTAVGAFVGTFLGIWIAETTGAGNPDAPVAPGQGIFGTSVGPGELVIPMTAGGFLYIASVSVIPDLLEESRSMKQAFKEYGAMAFGLFCMAVIAWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVH3</accession>
    <name>K1VVH3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_04995</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVH3"/>
    <dbReference type="FunCoup" id="K1VVH3">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVH3"/>
    <dbReference type="eggNOG" id="KOG0348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="InParanoid" id="K1VVH3"/>
    <dbReference type="OMA" id="QMGFERW"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="248"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="530"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="838"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="849"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD00803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="928" mass="100858" checksum="9C43C08AAC93FD84" modified="2012-11-28" version="1">MDDFELNIAAPSDGGVLKRQLAPKKGGRVKQKQAVRRAVKKFDSEPNYGATPKSNAKATPPAPKPAPVSRPASRPEPARQAPAPKPVARPAARPAASQAPIPQPPQKVKLPKAPIFDNDSDSDSGSDSDYETRAGPSRLPMTSAAPAVPAKPAAPQIVSGLFTAYQRLPKVKSEHVEVGAPTNAPVDTSSFASLGLHKFINRHLKNKLEIKAPTGIQQACLPYMLSYPLDPHARRDDDEEEGDNSAFQVSDDAPRDVLIQAQTGSGKTLAYLLPIVQALLPLSKLSYIDRSIGTLAIIMAPTRELAQQISKVLESLLTMSLAADDDDSEDEHYTRWLVSGLLVGGSTRTHEKAKLRKGVPILVSTPGRLLDHLQNTASFQCGKCMFLILDEADRLMDLGFEETITGIIKALDGRRRNEINAEKEQDAEGGGLMRWPYWNRGRQTVLCSATVDAKVEKLAGIALRDPVLFKAADKEKEEARAKKAEAEKNQIADAVAEANAIVIPQDEKFTPPSQLSQKYVVTPTKLRLVALVALLRSLVSDKANIEMAENGNKVIVFLSSTDAVDYHFRLLGGVTMGGPAPAKEDEDEESSDAEGEGSDSEDSDGEAKPKKEKKKKAAKKPSQADAITLESPLFPKTTIQRLHGSLPLKTRLASLKAFAEPSPNPSILLATSVASRGLDLPLVRAVVQYDLPTEGGAAEYVHRVGRTARAGKGGEAWAFVAPSEAEWVPWVEGKMGRAEGTDTSKVKLTQVGVEEVLRRGFGGKGYEYEQRATDVQLAFERWVLEDPNNAALARKAFASFVRAYSTHPIEEKRFFHVKSIHLGHLAKAFALREAPTAATAAAAPKKQKERKDKLSNKRKREEGEEDEPRKGGKETTARNETERRMYEAVRKQGRQFKSGGALGAFSGNSAGEFHVMDTSALEKMVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVM3</accession>
    <name>K1VVM3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000220">
        <property type="protein sequence ID" value="EKD04591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVM3"/>
    <dbReference type="STRING" id="1220162.K1VVM3"/>
    <dbReference type="eggNOG" id="ENOG502SC07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423464_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVM3"/>
    <dbReference type="OrthoDB" id="5599419at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="647" mass="71278" checksum="04923B9A70711328" modified="2012-11-28" version="1">MFPTVDHHPAPPARTVKASVTPSLSLLRTPTLFTGLTPTVQFRAKVQFHTKNLSQQTGETFPKFLKRMTSLRIDCLYQEDNVIFIDRFYYSLHPELRKMVPEPDTHTTFRALVYECEQVCHRIPAIQEGYRGWTASRTNTGNTQRADTNRRPQQQYNPNRRPANPTNTAATPGTRATVPAIKITPSMDGVPIEFQGDIRDPAVRAHLANSGRCFTCRKPGHTSRNCPDSKAPPQTNYQSTAAPRYHYSSASAEAEEPPADEEYYTQLFDEPDSGQPETATEELPDLEPSDETAPASGKYTITENPTSDKSIPPTPTVHISRPKPSVTATRTTGRELVEKQLKPRTFLVTLDVTVFAPPIKPDGQLDHDGPHEVIEAVALIDSGCTDNLISRRLVDSRSIPIRPMGQPKYPKLADGTRSSTPINEETAALRVRIGDHEEPLAFNVAPLPDYDIFLGAPWLSLHNPTINWTEGRITFDSEFCTEQCVPDKRMTQLPTSAQPQILKSCVAKLHFPSKSPDGKPLPRLKKMKPPKEVAQEIMALCATFLTSSDNPDSGQPDSSPLSPSTTATTTMPPSSTCCPDPVPPSESPPVKTPTYTVSPGTDMGDTCIGPSGEQSSFNVLFDDEDDMTPTQYLLHLAEVLCGPRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVV9</accession>
    <name>K1VVV9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVV9"/>
    <dbReference type="HOGENOM" id="CLU_1344086_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVV9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="204" mass="22730" checksum="D80E2C5B27318496" modified="2012-11-28" version="1">MAKARWPWIERHQRGLVLYVKVVGRQVLTTVSGRRDLERQRIPLDETYLRPFLTKATESSMLYRCSRGDCFWVRPFKPTSHDCISAAGENYPPEFTKGGKAEDKPKGNRHSQSMIPFGTWTFHDLPKAVKERAWASFVSASNPLGVDAQLFQPVRNDPTLFVPVVSPGFGPTVVPTRSNVQGPSQRKADYAGKVGAAASVGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWL4</accession>
    <name>K1VWL4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWL4"/>
    <dbReference type="HOGENOM" id="CLU_698656_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWL4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="395" mass="43901" checksum="503D96566ED9BD7A" modified="2012-11-28" version="1">MVFANFRSFLRGYELPALPPPPSTERSVSDVSWILLFLQGRLGLQAPVAHSSFLKPRPGTVEFVLDRDGPVSLFSVLERHLRAHPIATEVGQFTDAARLFTTIFTHYPPVADAEYITSLLRDLLLVPARLIEGLYFEKRAVEDETVRDIRWEDVSERTMISFANKYAGLVPLLEPVKSSPGKRKRSSTVSRVVPTVLSFEVQPERSPLVLTFGTVIGTSNPVLAIEVVSSFTREDILALHAALLNKDGSGLSLEAAGYADPIVPDCLRVKLQAPSRVPDGVVTALLEVFGRMMLHRRTQVVLTNWDVFLTLRLAPDGRVHVSPPYLRDRRGIPRHLPPQGPLELLVALQLVMRLNTERGLRKALDLKGGEEVEVWNYNGAHWFAVRDGKSALSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWL8</accession>
    <name>K1VWL8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWL8"/>
    <dbReference type="STRING" id="1220162.K1VWL8"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="K1VWL8"/>
    <dbReference type="OMA" id="HEPLDTW"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="28"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="460" mass="50616" checksum="996901DAEED5512B" modified="2012-11-28" version="1">MTDSNNPPSKNNMTGTIVPTPGIPDLRIRIIGAGMGGMGTALALAQQGFKDIAVYEQAPALGEVGAGINIPPNLARVLDGWGVLDICNGEGVVIEKANVLDCATDEILTSVSYEDYMEQTYGYPFVTVHRAGLQRCLVEGAKRSGVVKTHLGSHITQYDFDNTRFQVVNPETKQPEWVEADVIIAADGVKSKAREAMLARTGIKDEVEDTGQAAYRIMVRRSAIKEDPELLPFFTGSQSYRWIGEKRHIIAYPIESHDLFNMSTTQPDRNFVQADTWTAAGSKEEMLQTFHDFCPRVQKLLQLVPEGEVLEWKLRVHKPLPEWVDGNAALVGDACHPTLPHIAQGAAQAIEDAACLGVILSKIKDKKDIHSALEVYQEIRKPRTDWAVLTAAENSKGLHTNDKDARNAAFASSAPGSNPDKMISRDVHDKLFMYDIVKETEKQFEDLFSKRSVATTGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX39</accession>
    <name>K1VX39_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX39"/>
    <dbReference type="STRING" id="1220162.K1VX39"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006929_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX39"/>
    <dbReference type="OMA" id="DGTMRFH"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="887" mass="94270" checksum="D7D7B0DE60A68FBF" modified="2012-11-28" version="1">MLMEHPSQRLSVFQVLEVAHDLNGTRPSVDYSAYKQRMRPLSQQPPRQIKRNEKNPLDFTDPSETSRPAAPEVPLASTVQPQRRGRPTRDPREAALGVGSPQPMATHKTTPALQRIPSVKSSSSVQSMPTPPASHHPDPRLPSGSVASAKSKFEQQASKRMSLPHRSSQSPVNRLQVTGEDKKNVSRKSSVDAFGFHQSIPKVTSPLSFGDSFDSTTSSSRDGFSDAFGLKVNKPPQRQFTDAFKPTSGGDRERQFTDAFNPNSAKQRSVSTASGFSDSLSGSSAPTAQQRSVSGFSDSFTSPRIVTSPVAASPLAASPQRLVSIDSIDDSSSSGGTAEDTKSPASNADGDTSFETRFPSVEALHRRSSASSSTFTSTRQKSKELPQIPTIKDETKPSHIRRTSVVANRTGGDIPKNNHHTRLQQPQPRSTQVTGTAFKSQPRPGPDDGLEPPASNNQPTPSPTADYLDLLDDEETTELLAPTDLMDEEDPDEDKLALKPMQPEISKSPNSGARFGVPAKKPLPTKPKPALPAKPQLPTKPQGAGERATLPELSSARPSTNFNSDNWSPLEAAKVDAKSPPPQVDLDSSDDDEGPEDPVPWRRTDSPLQRARRPSPDILKRMSSFEPAPASPSSPTSKTGASAYSGYSLSGYTGTTASTGGSLRGRAVSGVSVQETHSRRSSVIDMKTHFEQLNTNSGTSANGAQAASGHARHASTASTNAAKPAAKPAKPEKPATLRRLSGPRPQPKSTGPKPPLPPTPVPKPAALRKGSVAGTGSAATGAGNASTSPITTSNASSNPTSTSKPAVKHGDAPSSLAYSKSSSGRAFPVTPKYAQSQSQSQQDAAERPPNPRTNSHDSNRSSSPEKPIPVKDRIGMWNKGEVRHARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXC1</accession>
    <name>K1VXC1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXC1"/>
    <dbReference type="HOGENOM" id="CLU_957082_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXC1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="30805" checksum="6A3619FF2EE37694" modified="2012-11-28" version="1">MLYAQPTSPPSPRSPAPQSHPARPASLASSIEEDDLYVSPKASPPYDTPPPPPQPQPAPPSQLAPSTMSNNDAPYNSNTLSGDFSALSDYKHRVPLLGADEEPHGAVNQAAGGNEAHEFSKRTVRVEVLRVEVRVSCQTGEDEEDVRPRCGKVELGKGQHGTAPLQRLAIGIWAARELLDDLDQGVGERRQHQVCATPVQGVRGPVTPDTVHGLVASIDCGLEAARGEAQRTQRLRRRVPDDVVCYLGVVVVVEDGGSALGKHGPGHGDQIGREMSSGAVVKSGGERGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXE7</accession>
    <name>K1VXE7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXE7"/>
    <dbReference type="FunCoup" id="K1VXE7">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXE7"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_4_1"/>
    <dbReference type="InParanoid" id="K1VXE7"/>
    <dbReference type="OMA" id="VWTLLQC"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000268">
        <property type="entry name" value="ATPase 4 plasma membrane-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000004">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="880"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="993" mass="108335" checksum="1DA036FDE3EEAB54" modified="2012-11-28" version="1">MSENEKHTPEEVPVKESSLPAPAAGAPPATEEEPKKKREYKGFEEKHEGDKHVKVDMNTISFTAADLYDKDKVDIEHVVMEEMFHLLQCDANGLTTAQAEERIGIFGPNKLEEKSENVVLQFLSFMWNPLSWVMEGAALVAIAMSNGEGKPPDWPDFVGIVLLLFVNSTIGFIEERNAGNAVKALMDSLAPKAKVKRDGVWKEVESAELVPGDLVSFKHGDVCPADSRLIEAVDVSMDQAALTGESLPVGKDEGDECFSGSTCKQGEAEGIVISTGPNTFFGRAATLVGQDNDQVGHLQMVLARIGSFCLVSIGIFVLLEILILYADFRYSYRRGLDNILVLLIGGIPIAMPTVLSVTLAVGAQQLAKHKAIVTRITAIEELAGVTILCSDKTGTLTTNKLTIDKENVKCYSHWDVDGVCLLAAYASRTENQDAIDGCVVGTLPNPAMAREGIELLDFKPFNPVDKRTEITYRDLRDGGKLKRVTKGMTGTIIDLCSRNKTSELEDRLEADVEEFALRGLRALAIAYEDVVDGDAQSPGNGFELVGLLSIFDPPRSDTKKTIEDAQDLGVEVKMVTGDQLAIAKETGRRLGLGDHMYPAKVLKDGPEPGSKHANLDEMIMDADGFAGVFPEHKFEIVKRIQALGHLCAMTGDGANDAPALSRANVGIAVEGATDAARGAADIVLTEPGLSTIVHAIYGSRVIFQRMRNYAIYACAVTIRIVVGFAIMAFAWKFDFPPFMVLVIAVLNDGTIMTLSLDRVLPSKTPDSWDLAEVFSFGIAYGLYLAASTIALYAVMNETNWFNDKFGVEPYRNNDYGSHMVIYLQVAIISQALIFVTRSHGPSWTERPSVALMAAFCIAQLISSIIAAYGNWGFSQVRAISGGWIGIVWVWNIVWYIPLDLVKFVMKKTVIAALQKRKAAKAAAPLVDESGERLQRTASRHESLYSNRTNFLSRATRRLKGGAKINISKNELERFSSIQAQQSGAALQRAASRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXH6</accession>
    <name>K1VXH6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXH6"/>
    <dbReference type="STRING" id="1220162.K1VXH6"/>
    <dbReference type="HOGENOM" id="CLU_1826647_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXH6"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852534" description="cellulase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="8">
        <location>
            <begin position="47"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="141" mass="15197" checksum="FA009B6EB6AB2FF9" modified="2012-11-28" version="1">MKFALLSVLAMLGSAVAAPISLNKRSLPRLGGVNIAGCEFGVNVWGWSGTSIRLPVGWQYLVNHDSSSKSLDASFFAQYDKLVQAVTSKGAYAIIDIHNYGRWNSGVIGVDGPSNADFARLWSLLAAKYANNDKVMFGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZB0</accession>
    <name>K1VZB0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZB0"/>
    <dbReference type="FunCoup" id="K1VZB0">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZB0"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="InParanoid" id="K1VZB0"/>
    <dbReference type="OMA" id="PCLSWED"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="10">
        <location>
            <begin position="54"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="42164" checksum="3E0E6155ABC7BAC0" modified="2012-11-28" version="1">MPVSTQSPDRQRPLDDDKVTGYDPLIPPALLRHDLPVPATAAKTISAARRTVRSIVRGTDPLDRLLVVVGPCSIHDVDQAKEYATKLRQCVQEGRWGGLEVVMRVYFEKPRTTVGWKGLINDPDIDNSFQINKGLRIARELLCDINAMGMPVGCELLDTISPQFIADLITWGAIGARTTESQLHRELASGASFPIGFKNGTDGSVGVAIDAMQSAAHPHNFMGINSQGMASIVKTSGNRDCHVILRGGSKGPNFKKEDVQAALGVMKKKNPEDFASIMVDCSHGNSNKNHRNQPLVAEDVAKQIAEGELSITGIMIESNLREGNQKSDKGRDALEYGVSITDACIDWETTVQTLDVLNKASLTRRELLAAQHAASDANPAVQRVKDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W246</accession>
    <name>K1W246_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD03003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W246"/>
    <dbReference type="FunCoup" id="K1W246">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W246"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_1"/>
    <dbReference type="InParanoid" id="K1W246"/>
    <dbReference type="OMA" id="CEPFKVE"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="314" mass="35021" checksum="B25BFB70F2CF713A" modified="2012-11-28" version="1">MPKLKLLSKGKVRDIYALPDEKDADKLLFVATDRMSAFDVIMNNGIPQKGATLTELSLFWFHKLRNVIPNHVLTPSLEGASPAALNGATAWEEFPRSLDEYRDQLEGRSMIVKKCEVVKIEAIVRGYITGSAWSEYKKSQTVHGIPMPAGLVESQKLPKAIFTPSTKADLGDHDENIHPDKVKDICGPELAAEIERVALALYNEAAAYALERGLILADTKFEFGLLDTPNGKQLILIDEALTPDSSRYWAAADYEAGKPQPSFDKQYLRDWLIKENLKGKEDVTLPEDVVAETKSKYEEARDRVMGRGKFAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W311</accession>
    <name>K1W311_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W311"/>
    <dbReference type="FunCoup" id="K1W311">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W311"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007157_0_0_1"/>
    <dbReference type="InParanoid" id="K1W311"/>
    <dbReference type="OMA" id="XQGGLLV"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1190" mass="128460" checksum="FE98E1661506E87B" modified="2012-11-28" version="1">MSGGRRALTAMVPSLSDKFKSADSDLRIMALVDLNKELQHILNEKPVAKTAFRTQDPSYTDETAEKILTEMVLGLLGDSNAEVKNAAAACMSRKARPNYLRQIVANVTEGIGSPGQKVDEESRDICCLANRQLASELLQILADIYARFGNAIASNAKLQDLSLSCFLEVMSSAPLSVRKRAVPALASFISICPQHFQSLKSEMSQGFSAGGDTAKAWVAAVAGIAKTSAAGDVGALIANDNLVDVILKQADDLEDADAVEGALTTLALHCPSELSPSVPKIVERALQLVKYDPIRRSAAKLLTAIISTRLDLLQDLYKTAAPILVARFAEREESVRLEVIAAFNALLQQTANARSADLAASGRNKRKRSEGMDEDSSPDSITAALLTMRSQIVKAILKQTAAKTVATRQESFVLLRRIVEALDGGLESEADTLCQAAKGALRSSDSTTPSLTIAVLTFLAAFFNHHVARSYAEHLSELTTAITRCMKDKLQRVNFEAFATASALAQSLRPVHPGFRAGSGSASPLRQGYDGPVRQLFQATAEVLGATSVDGDVRERALITMGDLLVHEGDALSQELSSALELIKTRLSNESTASTATVVIGRLAESPLVSGPVFDAWLLEVLQEIVVSIRRNKRSASKAAEFTTLERILKRVGNALPAEVADGIILELQPFIDTPAALRVVALVLQDQPASRTSVEQNILPEVLNVIRNSATATLIDELPSFFSTYVAGDPESALRLVPTLVMNVTKGSSADSTLSRSVAFQTTAKCIGAVVATSQRNTSGILATFQKTLESKSASTPELYLALLSIGEIGREEDLCGNGTLFADVLKFFNNESEEVRTAAAFAAGNMAAGSPETLLPQLIQQIQNAKDEAGRSLLLYALKEVILNSSPAELEKLTDILWGPLFGDVAASNAAAAVSDDGIRNIKAACIGKLTAVTPGRFIPQLQTMLQSTPQQRALVAASIRYTLIDSSSASNEIIAPIVNDCLTLMADEDLVVRRLAVAALNAAAQNKPYLVIDKLGQLQPYLYRETEIKPELQREVQMGPFKVIEDDGLENRKTAYEAMYTMLASCFNKIDVPAFTERVMAALRDVNEIKSLGLMLLLRLANLAPAAVIPKLDEAAESLKTIMKDLEVKDDTIKQDLERKEEMQRSTLRTAIPLYNMSTPAQAPVFHQFVGGLLKMDQWKEFRDYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W594</accession>
    <name>K1W594_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W594"/>
    <dbReference type="HOGENOM" id="CLU_2211810_0_0_1"/>
    <dbReference type="InParanoid" id="K1W594"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="107" mass="11906" checksum="65D3DD05774B0439" modified="2012-11-28" version="1">MTFPSPLTVPNWRRSPASSTTTTPSGSPDDRLNALLEHCESGTHSFQREREELAKANAAAQAATKQQQQEPAQQPKRGPLMSLLSLTRPREESHFDPSKNPKLHHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W604</accession>
    <name>K1W604_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W604"/>
    <dbReference type="STRING" id="1220162.K1W604"/>
    <dbReference type="eggNOG" id="ENOG502QSID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031144_0_0_1"/>
    <dbReference type="InParanoid" id="K1W604"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852282" description="Alginate lyase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="371" mass="41449" checksum="515D209392EB4709" modified="2012-11-28" version="1">MRLPLLLLSTLGLLYSAEAAPPPHAGRPLQRPRPGTSVFEPKRMVKTAREVSKGRHDGELHELLSHADPYLSKGPWTVTSKTMDVPDGTRVYFLSLAWWHTDKPEYRKKCGEVLRTWFIDEKTKMTPHLLHSQIVKCKNTGRSIGIIDFAQQYTDVIDAVALLDITHDDAWSDADSEAFKNWNRQYLDWLKNSNFGKEELAAKNNHGTFAAMQIAAIAAWLGDIGTARSQLEAQRDLIPQRIAADGSQPQEIVRPTSYHYSTFTLVAWLRMVAIGQRVGVDLWGYTGPNGESIPKAVEYIIPAAKGGDWPHEELHMKRFAAYGIVHFAADMGMRSAQEALPSLETAPTGAFWNLGPAVQQLDSILLDQVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6S9</accession>
    <name>K1W6S9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6S9"/>
    <dbReference type="STRING" id="1220162.K1W6S9"/>
    <dbReference type="eggNOG" id="KOG4011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397942_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6S9"/>
    <dbReference type="OMA" id="HELIPFT"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="110"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="643" mass="69705" checksum="40483BC65CE4CBA2" modified="2012-11-28" version="1">MDATGLDAGPSAYDANAYSLNSPDAGPSNDPPPSGRGRGRGRGRGRGRGRGGGRQSTRLSTRQAASAGPTKLKISFKASGGAAASGGRMQSFLGEYDRELDDNPEDPLAFEEQFILRVPPSVADGKNGELGLRDLIKGKGRGLDALEFKMLDPRRGVFKIGDTTYTSKLVDLPNIIECQKTLDNRHLFKVADISQMLVVEKPVQNEASVTSTPLNVDDYIWPHGITPPLRHVRKRRFRKRLSRRTIEVVEEQVEELLNKDDDADETNLIDVNPDPDVPDSYYVNWSAEDPYAGWQPEGSEYGGEEYQAQPEGEWYDEEEYPEEDENEMDEDLQAALMDQLEQSESEGEGDEDEDGLSASEDEEEEEAAEDDDPEVAERKQKIKQYTSEIKQLEQLIEKKRAGFTGSGNPIITKRFEETIKGLQDDINNKVSARQALQDAIDERRKEKEAADNPPPSAAEAAEGEAAEESEPDDLFDDDEGDADATPIGTPITPAAPTPGPDEIPDLPSGAGDDDDDEDLFGDDELLDDPAPEAAPAAPAAGEGEFLANEMDDMDEMAELLEASLNQADEEGGGEPMEGVEGADGADGEIGDQAAATAALDEFMMSAEARDPGYGFVEGGVGMRRLATGVDDSSDEESEDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7C3</accession>
    <name>K1W7C3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7C3"/>
    <dbReference type="STRING" id="1220162.K1W7C3"/>
    <dbReference type="eggNOG" id="ENOG502S1AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052711_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7C3"/>
    <dbReference type="OMA" id="WVLVNEL"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="364" mass="39741" checksum="1BF5ED196BE0C008" modified="2012-11-28" version="1">MPHQVDEEDLAEVWVLVNELTEQLANNRALVQQLKARTENVKGQAVHVGAGFPLRRFNLDISDEEFQTELEAFASHLVLENQTLQHENKQLNTLLKEYEQTLETVMGKFRGVAHHDLALHSYYSQLLQSLQTAHSTAQLHDDTSLSLLLTRLSTLLRSALRTSNGEEVDGDLLDSLTLEEPRASGPASTSPAISVSPQSSPTRSPERGSAGATSSGGTGSGGATSSSRRRRGEFGFVPGSSGGYFGTEGQGDWALEREMEIQRLEEENRALREMLGIATDAPPSPPPQQHSPIIGEDRRLSALTIDELEADAEKEEAEKERLGDAPEETEEKAEVDESVLGIRAQADQAPPPENVFDETEGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7X8</accession>
    <name>K1W7X8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delayed-type hypersensitivity antigen-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000168">
        <property type="protein sequence ID" value="EKD04983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7X8"/>
    <dbReference type="STRING" id="1220162.K1W7X8"/>
    <dbReference type="eggNOG" id="ENOG502SWH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055507_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7X8"/>
    <dbReference type="OMA" id="RCEAFAC"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852749" evidence="1">
        <location>
            <begin position="20"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="272"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="361" mass="37407" checksum="4A4EC09EF2E86937" modified="2012-11-28" version="1">MKATFFIAAALSLVNVATAATAPVSVGSFAPVNLEDLLLTTLNGLVGTLSATTLASCAARCGAARFEYTLFNVGISLNLGISVITLLPSCVCAQGAAFDNADLSETKVVAAQDSSGDSCVAEAFSLISLGVIYPVYNVQRTQYDVATVDQVSISGCYSSVTLNGVVVPTTIITNPDTCFTTCRDWRYMTLTPVGTTGTYSCGCGTVITLGSSITCTNSILVVYSNSLAASGNLVARRRRAAAIAARTAKNCPASYSECLVNTPTTSTVASLECIDTQSELESCGGCVNGDYTSDLTASSNITWSGVDCTAIPGVSVGSVSCVRGQCVVSRCRRGYRLGDGTCITDATLKIQDATSYFKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7Z8</accession>
    <name>K1W7Z8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7Z8"/>
    <dbReference type="HOGENOM" id="CLU_940698_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7Z8"/>
    <dbReference type="OrthoDB" id="10578241at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="32172" checksum="172BF90C1C1FDE31" modified="2012-11-28" version="1">MHAQGPILAIDVQYSDDDTGYAAGVLFESIDSSNPAQSIVHIHPNVSPYEAGAFFKRELPPILALLDKVKAYPAIIIVDGFVDLDSPDRPGLGRHLYDCLDGKTIVIGVAKNPFRRFNGDKKALPDSPHVGINNVTLPTMGKDSIHDRYKEDRESGADVKSFFKALVSGSTASGMGHRVYNSADRGSGQMGQHIRDESGAQVESGRVYYQAKPAPPTAPTATSPTDVQRYLGPNQEFNPDYAAAVLSNFVRASLETGVDGVEVAAQLDDLERRYGQVGVFKYIRDTYRLGAPPSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA33</accession>
    <name>K1WA33_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA33"/>
    <dbReference type="STRING" id="1220162.K1WA33"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392414_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA33"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="703" mass="76715" checksum="803BA0F3430E32D9" modified="2012-11-28" version="1">MALELASRFKNVTGIDPEDSMVAAGLQPEAGNEIRYAKGTAEDLPAVGLGANSIDLAVAGEAAHYFTHENSWPQLAKALKPKGSIAWIIMSSLMDATLSPYWSEPGWSISEGLYDRIPFPVQPDADKTLVDKLPDLEGNGHALDMLIDEPKPTGDPDGAWDPSSALRCKSGTSAGKWYLKEHWTLAQVEKCLRSWSGVKRYQDKNPGDLDGEQPDVVSRVIAQLEPILGPEFNVAWPLVVQFIRRNSCSLRTVRHQPPNLLISSLALRHRPFPPPPFPLHPAAGVTGGIGTMRSDLTYFPHICTAIVASAPASTLLTLRLVSPLFADLVDRRLLEHVVYGVREARLVSFLLPDHPLPNFSAEAVRVLDLTMSLRFADRPPDDAHTSIMGGMLEGRIVEDVAGISVSDELWSGNAKAPWVLADPPRTPNGSSPDEVQLPDALPHFPNLRVLRSLNYQPVVFPHLLRYTCVPVVVYPASRAISWSPSRRAGGRLIGGSIRAPRAVIAFDRPPEGDFSFYFRARQHERLDIVLVPGQWKESLGRYGAGAADPASQPQLPPSYDAAELPRYTTSEAIVHTGNGLAPVVVLPEVGPRNPLRGPPLVDRVTSGTFWTCLTDEVAHHVENGGTCTVVGLEAWDIITRGSVPGWDGSWAEIMTRDVAVDEMEELGLEAKEGGVGKMGALSFATLDEWRDAEENTYVWDLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFN0</accession>
    <name>K1WFN0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFN0"/>
    <dbReference type="HOGENOM" id="CLU_2308038_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFN0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852850" evidence="2">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="100" mass="10177" checksum="55B4022EAE1FE0B1" modified="2012-11-28" version="1">MLFGTLLALACASAATAAPLLARQVSPTYPDGSIAPVQPAGDQTGALQGMMGGPMNPVENGATADAQMESLADAIKNLQEVNDLFDKFIKKGKDAAQGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIR2</accession>
    <name>K1WIR2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIR2"/>
    <dbReference type="eggNOG" id="KOG4136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235804_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIR2"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="224" mass="23816" checksum="CC9F8A64B3B9BC3C" modified="2012-11-28" version="1">MWFFHFAAVAQEAKRSRAARYRYHAHPVKEAPTFMEVASFFAICVWFVPLFLFLSLSANDNVIPSHFGTPTPTPPVPVEGGHAAPRRSRPGASLVKSALAPVMGLIPRIGRRRDTEGLIAPRTPGLSPVPSSVSLNGNYVPWGGESSPSSPQAFSPMASYSGLPGAGGSGFSTPPPPKRRVSQSSVNSEIELSGMDTGIATGKDKPVRRAARSRVQSRAGSPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKC9</accession>
    <name>K1WKC9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKC9"/>
    <dbReference type="STRING" id="1220162.K1WKC9"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_1_1"/>
    <dbReference type="InParanoid" id="K1WKC9"/>
    <dbReference type="OMA" id="LLPYLWF"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="104"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="659" mass="72267" checksum="4BDE80FC46DC7CEB" modified="2012-11-28" version="1">MSSSNLSVAPATTLSPEAPTPSSDSRISRDSTKVDLQAFKDSSKSLKLEKTLTLEPESDIPPLTLPAKVNSDLALPRTDSDATAATDASEERKRGLSAGKRWGLLAIFSMAMFIDIWCYSAFFIFTRPIAEDLHIQFTQESWVITSYAVTFASFLLFWGRVSDLYSAKPVFTGGFIALGVLNAVISFLPEKFSFFILRAFAGIAGSALIPASYRLIVHVFPKEQLGVAFTLYGMSGSIANVTGTIVAGFIQFIPGGHGTQMQSWRWFFRLLAVMILPMALAALFMIPKDEGEDADMAPREKLVRLDVPGSFLMLSAIVLLTLGLTLGARLRLAAHALHGRRRHPRLDAGHARDPHLVPASKDRPQALCNLPPRRRDGARMDERGGDREPDPQGGIQRQRVSGRRGLELDPDESRPRAPFLVPFLLSWALFPAFFIWEAKIPQCRALLPAKTWKIPNFAVLIVFALQIYAWWGVNFLALVDTFTKVRGEPAIIAAVRLLPQGVLAFVVSIALTKWPQFVKKPRWPIAFGMVLGVVGYVLMTRPNQYNNSEYWRFLFPGFIVGSGGMALAFTATTVGVMTSTPAEMAGVAGAVLQVAFQIGSTVGLSVQAGLLTVGSWPGNVKASLYFQMGWCALWLVGFLALYRPSKNVTNDEETVIVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMP5</accession>
    <name>K1WMP5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMP5"/>
    <dbReference type="STRING" id="1220162.K1WMP5"/>
    <dbReference type="eggNOG" id="ENOG502S56Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872053_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMP5"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852982" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="114"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="319" mass="31444" checksum="94EE1B75DB287EE9" modified="2012-11-28" version="1">MLLKTFLPFLALASFVAAQDPNAGGDQGAVEGGDQGGGEGDTGGDTGGDTGGDTGGDTGGDMGGDTGEDTGAEPSPSPSPSEGGEEAGPTPAPEGDTGGDPNAGAEAGVSPSAPGGDAVLKPGQLVSIQWGDVSGDWTNMTIALMTGTQEEPNVATVVTEGVDATAQTSFTYNMPDVYPYSKVWFFQFSNNGADSWPRAFTPRFTVQGPNGEQIDPPLTETISGSAIGYAQNGYTKGANGATSAVSVTGGKPIATGQAGNGVTIYTAGINTGTDLPDGITVTGIKAATDHSVDPSSGKRNLPALGMLGAAALGAAYVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQX7</accession>
    <name>K1WQX7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metabolite transport protein GIT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQX7"/>
    <dbReference type="STRING" id="1220162.K1WQX7"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="K1WQX7"/>
    <dbReference type="OMA" id="RGPIFIL"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="73"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="535" mass="58283" checksum="30F36EAFE2E9AE5B" modified="2012-11-28" version="1">MSQEAKADKSSFEVDDEKNIAALPNQGFEGIDDKTLQYLPKDITPSELERERALEEGETPSGTKKATVSDYFTLLASGFALVSDGYQNNLSTVFNPIFTLLYPHDYTSSVSTRVSNALLVGEVIGQVVVGLICDRVGRKTAMVGTTLLIVIGGILCTASTAPTPAGMFWMLTVARGTIGVGVGGEYPACSTSASESANEKFGRDRGKIFILVTNLMLSIGGPIVISLFLLIINGSHYHGGTTGSDRYKLQYTWRVLFGIGIIIPLSVFYFRLKMMNPKLYRRNAIRHNPPYLLILKKYWKTLIGTAGTWFLYDFVTFPNGVFSSTIIASVTPDKGIVRTLEWNLLLSVLSLPGVFLGAWVVKYTGRRNLLIMGFMGYIVFGLIVGISYPKLTKVVPAFIVMYAMMQSSGNFGPGNMEGTISAESYPTSIRGTCYGFSAAVGKAGAAIGTQAFTPIRQHLGSRWTFIIAACCGLAGVLLAFFFVEDKGKDRLEKEDEVWRQYLVDHGYGDIQMGDGSAGAMSASGNREIEALEFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRA9</accession>
    <name>K1WRA9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRA9"/>
    <dbReference type="HOGENOM" id="CLU_2414864_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRA9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="92" mass="10052" checksum="79BBA716405978B9" modified="2012-11-28" version="1">MTKPRRRPRSSEELRRNGPQRQAKFGTSENPNVPLPVGPHGAHHDPSQTSCSPIDCDPAVGNQRFGPTSPTQRTALKLLVPRACVVEGVYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSP3</accession>
    <name>K1WSP3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell polarity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1WSP3">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSP3"/>
    <dbReference type="eggNOG" id="KOG1825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000325_1_1_1"/>
    <dbReference type="InParanoid" id="K1WSP3"/>
    <dbReference type="OMA" id="MRADTMK"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="396"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="967"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1749"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1970"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2349"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2511"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2350"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2523"/>
            <end position="2557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2603" mass="285289" checksum="2D81E94BA6B2A693" modified="2012-11-28" version="1">MTEAIVIPDFDDDDDLTLPSFGRSAFGTGTASSSPEPDVYAPPPQRSESAMSFDPPSSTRFFGSLPRPGTSKGASGLGQSASSHDLGLDPPPVARLGKFSNGSSSSLLAHGPHGSGSGPSLLSARKGSFASLKNVFKSQDKQSMPAVPPMPSSQSYAQQGQPGYPALRNPFSRFDTPPSPPSGTSSVSTRPRERTKLSQSHVSQHSTVAPSVHYNERKQSVATLGSSHRSYGGRSNTSGGSSNFRAEDYPMPAMPSGPYRSAPSRAGRQGSDTSGLGSFGKKSSISGIHMVEAFESFGKTPAEEALKVVFHSFRELAEKKMKKVTSKPLGVDSTFDDTLNQLANCSRRHARRVLDVLSSWCRVQCEPMIAAEVRSQLKQSMVQLRPDEAAYILNSRKTSAAKYMYYRALFGIVQSVPPQDLGEDVALNLENAAFNLFKSERPDDYIRKDLSNLLVDFLGELSNNRFLTVSERFTHEIGTLNAAAPKDLDARVEHILKGVRHLKLKVYPDDNLEMASEFLQTLSVFFVNAHGNSLKSAFAETFTHLLHPVIESATAEVNHPLWSKAVATVLQRAMVMASKPRYWNVAFPLVVVALSVSPREVFMEHWQACIDSISSKTKDRTSRAVGMNAFVRLLWVYLNRCPESSTSTRRRLEGLLRNHFPVNTGQLLPTDLPLDPFVAILHYVMARQFDFGQELVAEFLLDCVPPRAADGSAGEVMFPERAYVAVQAATKTLECLAANNPVSLPKSADFTTFDFDAIDCPNLPESIHNIPEADEFLKRCGPMIINVLLSCDRTVGSVLLSGDTVTIAAHASSAGWEGSGEQVTRKHGDVHVGYPKQNESTFRLLAAVLETLPFLLPTSNVTSSNDNIINILCRATFSADPMVCDVASRTMRRVAQDPEIGRSLVDRYRQFIFETRHVFRDHFIGTRLLESQLVRVVKVWVDVLETLATHQRSMENPVPFDAEYVNKVDGAGLFLLCSSSQNLRQLALPVFAAARDFTGEARGPSEPFRYSRVLLEKPPISCVLQMYEGTVEESDYIALSRLAAFTEQDRARLAAIRVPKLIQHIAESQQSKDAALWAVILPAFIGKVYDSLPNSVVELRSVLASTVVRNISHLSSVANSRNPRLHTNPSAVNRTTSDPAILADQWRLYFSVLCAVVDPTKSLPTPRKLDATMSPEVVISPAIFPFLIRVMESEDKRFQDAAVYSLGSIRLPALSQLSEALLYHVRRLYDQNGSRNEPRGQTRESPTMRRPSLSGVQWTAAAHVFRLVSPLIIDGRSPNHLANLSNLIGFVKITFNLLAEPLVQVDYDLQSLRRYFCIVVDNLSTALGQLGGSDRFFSPDTRAGIFKLCYDWCNVGRRPDIAKARVSHTLQQAADSYRGDDKAQYVDVLQSKMKLLSAASAEAMASLCLGRLISAPETVPSQTDHIVDPLMVLRWIRGMFQTSQSSNHDTARKALSALIKYNWDVPRLSDEVLHQSFGEGEHFSLDASFFGILADVISDGTIKLPPAQRACLSLSKLGHPVAAVRQRAFQLAVWLFDDPDDQLSVSGLLPLVGSAAPNVYRSAQLEMATKLANLYPQLAFPFLTECTKRLGQLEAPRRQATLSILPPFLKVLELEADTSELGPEEIALEHQSLLNIMYLVVRFSADHLDEVREILLSFAGTGQSRNTRALIKFLFEQGAKRGSPDFVQHAQQIIAALANSPVGDVIFEEICSFVHPSDMASAAQTDVPESPNTSLANLDALFTSTLRTKPLSQGQMALLFAGELLPHRLSDPSLRTRLPTLLHVAFIHCDDPNTSMRESAQAVLFQVLRAWISDHTNIQNMPPAERAEIWNGAEMMTNKLSRHKADLFWSYDDAGSSQTFAHAPTPMSTLLFKILGIFQQLQPTLRKQWGTLALNWATSCTIRHLACRSFQVFRVLALDITPRMVSDVLARLSSTIASSSPEIQAFNNELLRTFACIVRSKSEDEMRNFPQIFWCAVACLTTPYEAEFNEVVDLLSHILDKANLADPAVVSHLVSFRPSDLTGPPPHLQSLLLMGLRSSTTDMMTFDVLRRLTSVPSSELIDEEDGRLLHGFAAALPWMLHSTDLGEPNEELAGMATDLADIAERRGNASLARLLTSFARNRFRAKDDFIRQAAQLLRDFLKSQPLELVTILLGFTLNHNDWMREKSLQILKLVLAYPEAGPALSPHARELSRPLLRLVSTKHVSSALEVLDLPPFNNIDASGPDTTDPIFGPIESSGWSVPNASERSEVTRSNVQAVFNTCAVESRAASAHFSVLQFSDLANGKNGSNPNIDGKGHMKSVNASNSDAWPSNGSLIEMPSPPVSVPDNASMGDLVGALHSLNLFFDDSLDQPSNGTTSPLQTRRKNFGSFGRASSSESLAMPMQDPRVRAIMTRGTRSPTAHLQDSAYKATAAARSTESFATAVSDGYYTVPGEGPVAASSAPVVGGYNAYSSSRAGSRMGDRANDNLNVTGHAPHNPSFSSESEFDLNPSAEQFWLDEHPPNGVNGLIRPWEDEQNRNHPNPTSTLSTPTTTTFSATPTSTSTAATTIETTTSRSPPACPHFLPSHTCKPNLALEPTAHADGLLCRANQVPHARVLGTATAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVD1</accession>
    <name>K1WVD1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVD1"/>
    <dbReference type="STRING" id="1220162.K1WVD1"/>
    <dbReference type="eggNOG" id="KOG3465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144337_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVD1"/>
    <dbReference type="OMA" id="NTRYCVK"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000008">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.11, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="140" mass="15231" checksum="4EAB4DF9EE0239EB" modified="2012-11-28" version="1">MVYVPTWTKFESAVIDLYNKSPRKARYVVKFVPKTGQLVLKVTDDTTCLMYKTHSAIILNRFESLNLRLLSQMANVKRRAVLSPPTQSGQATPATPMTEDDPMGSPKKGGSSPRKGSPAPQAQPATGGGGGKKKKKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVD2</accession>
    <name>K1WVD2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVD2"/>
    <dbReference type="STRING" id="1220162.K1WVD2"/>
    <dbReference type="eggNOG" id="ENOG502QSAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1723618_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVD2"/>
    <dbReference type="OMA" id="DENPEVW"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="152" mass="17023" checksum="706065B61044F4A1" modified="2012-11-28" version="1">MLPELPARLQFARLLLEHQLHMEALDVLSTAREEDSLEVEAAYLEGWAWYLRAEAILENPSLLQKTSEDEDEPLTAEECFSESFRCLLECAKLFTEQEYPDEGIGSHVQELISNLEAKGVKPAVAEEKPEGVEGAEAEGDWEDVQDGDVNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXQ3</accession>
    <name>K1WXQ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXQ3"/>
    <dbReference type="STRING" id="1220162.K1WXQ3"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518938_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXQ3"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="525" mass="58285" checksum="36B45CDED1DD8E10" modified="2012-11-28" version="1">MRVSASCASLPTESAKPSEVSWSCFPELTADNNVPLLSRLQYKYDLRNTDKRRITSLAWAALELNLEVFEWLLLDYGHDDHELSRDSAHNTIFHLLAAAPAPPALSPNAEIWAGAPDFPPRPQTRPQAELTDICPRMTEVYYTLFPFLLDWSNNRGETALHVAAQADNPAFIACLIELGADPDLADLDGNTPLHCAASWGHVACIRALLERGASVALRNFENFTPADVAYSNSVRAAFDSMARDVVELRRQRKLLQQQREELDDYDGEEEEVEDRFDPNQRFDPRFDRYGSGDRRPSEGAMERTESERGFGRRESVSGRRERAERQYGELDRLERMEPLPSPRSPRGGRFRSGSGSTASHTGSRSSSHSYSDHPLPPFPLEAQPPLPPLPDRYARYSRPGSPTPIASRQGSESHVPMLAHHHSDYTPEQIQAMRPVPPMPFAAAPAPVPGYAEDELGSRKRAHLGDAPGCEHAGTPGAGEGWAQDCDSGGLREEQETRTPDRDSGPTPPSRYQEPEGQPQSETHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1V082</accession>
    <name>K1V082_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V082"/>
    <dbReference type="STRING" id="1220162.K1V082"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_1_1"/>
    <dbReference type="InParanoid" id="K1V082"/>
    <dbReference type="OMA" id="NEFNGLW"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851527" description="ABC transporter domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="385"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="986" mass="105695" checksum="3BB6E7FF8FB583BC" modified="2012-11-28" version="1">MRLPALFAASAALWVATASAARQCTHYGLPEGDECTCPAGFGASIGSQCDTPQCGGSLYVPGPKAKDGNLKDCKCDDGWTGPTCTVCQSNQACSTSLNRYSWGTKYSQVPGLNNTLICSASPTVYGTGQMTCSLSDPTINMLFPGPAYVTITRSLNSTKHPGGKRVLTKGGLNGGEGVAYAQIWINNVEQFSCMAQNCTQTVAKSKIDGAAGNSTTWDCADLECRCNGESDLCRSPGVLGIINKLHGPLSVDCGGDDNCQFKQQLVTNFFGEKGLTLSDCTFGECVEQSTIDNASFDTNVPGPSAGVIAGLLAVACVILAVIIATVNGIYSRERARRRPTHGDFMKRPGVGLSWSGVGYEVPPEQRGFIRAFKEWLKGGRGAAYLKLERDVNVGPHGGKVVLRDSCGDIPAGGFCCLLGPSGAGKSTLVDILSGQNKAGHVEGSVSYTGGGRIKVAYVDQRDVLSATATVAETLQFAADLRLPENIPAHVKAERVRTVLQQLGLEHVADTRIGSGETRGVSGGEMRRVSIGVELISAPDVLILDEPTSGLDSVSAARIVTLLKAITEDETCPTTVIASIHQPSSALYNAFSQVLLLSRGKQLYFGPGGDAPADYFARFGLPCPAHYNVADHLLEIATASPPLQTGRDAVVPLNYKSKEARLLEESESELSSAGSSELDLLCAGETSVDLSQRQSVPKSAWWPDGRCETTFLTQMDVLSKREWANLMRDKTLFVSHVIAGIVLGLFASGVFSRIDLSISGFRNRIGCLFFICSLVSFSSLSALNNLVEARPLFLRERGGFYSPSAWLLCRVLFDIVPLRIIPISLLACTTYALVGLTPTIVNFSQFYLAVMQFAVSMALFNFILAAACSNPALAVLASNLWNMFNFVYAGFFVKLENVPAWVRWPTYITPLGFALEAISVNEVGAGLPIKDDLDGIAIEINAAYIMKRLFGYELGKYYGDVLALCWFLIGYLVLLVGLVVYHMREHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0I2</accession>
    <name>K1V0I2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_08251</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000411">
        <property type="protein sequence ID" value="EKC97444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0I2"/>
    <dbReference type="STRING" id="1220162.K1V0I2"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436270_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0I2"/>
    <dbReference type="OMA" id="HSTIDFI"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="154"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="407"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="627" mass="68515" checksum="F8A8735A29EE4947" modified="2012-11-28" version="1">MFRALRISTRTTTSLRTITTSAPAAGYVKSGRGGSSSSSGSRRQSNSQRLNRFDNRDDRPRRRPDASGQSIAWRDRPSSVPQVPRPPRTKEEKDRKLPAHRQEANIIMSQPRDFSSFELNPAMQEVLAQKGYQKTTPIQSLALSEILASPPPEAEGAASRTAAILGAETGSGKTLAYLLPLMQRLKEDDRPGPRSGILAPRAIVLAPTHELTRQSTAVAKQLSHGVKLRVAGASSPGTVKGAGGVDILFSTGRRMAQLLGLERERGERVPVERKRYDDQEPEFSPARLEWLIIDEADVLLGSAFADETNAILRRLPRNVNVLLVTATLPPALLAQIGAPDSPLKDYEFDQLLSPGLHRLPAKLETRFVPWSKSGNMYSDIAHEVRRVFAEEALDAKNAAHDEEAQRGLKPGSVKPQRNMAVVFCSSLGKVAAVSKALEERDIKCLPWTGDSADRKVGRNGPLDHFLVDHNKRPEGLEIPKPPKQVATTDDGQPIAVTEAEAEAAENENEGEKVKKEQPESEKKKPRVLVTTSLLSRGLDFSPLVSTIYLVDPPRNVLDFVHRAGRAGRAGRPGRVVVFGLQHAGQSKYSEQLKEVLRGTERRKAAKPGARTFEGVKAHGGGKGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1A2</accession>
    <name>K1V1A2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAO1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1A2"/>
    <dbReference type="STRING" id="1220162.K1V1A2"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1983132_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1A2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="126" mass="14139" checksum="CF0EE1E47D0F2D79" modified="2012-11-28" version="1">MSVPTISLHDFAARRVEITEGLMRASTEVGFFTLSNHGIPQEDVDAMFAFSKRFFALPDEVKAKTPLNGKNAGWEKNTQVRPSTGTADQKESLQLQFARMEGLWPADEDIEGFKAKAEAFMEQIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1U2</accession>
    <name>K1V1U2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1U2"/>
    <dbReference type="STRING" id="1220162.K1V1U2"/>
    <dbReference type="HOGENOM" id="CLU_361763_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1U2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="6">
        <location>
            <begin position="177"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="83698" checksum="9174F1E93011F165" modified="2012-11-28" version="1">MRDHVKFPEGYIYCCNHCTRIFSERTAFTRHNQIEHPKEMTLDLLYWESKPSVSLLTSGPATPGSAGNASAALCVIRTSPPTSGCASTCGDARSKYASEAAGELRWSTFTDVSLPRWWREDEADDEMDARWDRWQASDGDSEAEGDGARASDDDDDQAFNPEENLVRLYIAAARLGYNLVDVPGDGNCALHAAVHGLRPFGVDADVPSLRAALVEAARCDEEFRDNALSLQEEAELDEWIVKMSHMEEYVDHMGLAALATALARPIVVFSPSSARVATHTPSHVPNMGDPVFLALKPQSFRRDLEAPGPPHIQARARVMLPNLLAEHDRRVANLPALIANAESISVRDELEANGKRLARSLVVVVAGLERGVPPELAGKGNLGIATVSVQGGHGTQSGVAGFGERTSAPDLSSVAGRDGVAGLGDGRAAGVDQAGARAAVGDQAVAYVDGRDGTSGARIIIGGLAIRPEVMDVSLEGGPLLPVTDDWQVESFETALEALTISDSDKSKEKRKKPSDHNGKHLCPHCDQDFASTQGLRDHVKSHLGYVYACNHCPRSYTDRTTFTRHMQLEHPKETSLGLHYLRLLQVVKRAIRILAQRHGWRSTSGNAPPRSASEEDGKSRWPAFTNVSFPSWWREDEDSDAADARWERWQVSDGETEAEGDVAMASDDGDTDSSADDEVTGSDDSDSDSGTEAQVQREKVLLELSPARKSRHPHAEAPPGRPAPSYGVPKEGCEIPGCALAYTLSENLQKHIAKKHPGVISYNCEDASGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3A4</accession>
    <name>K1V3A4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3A4"/>
    <dbReference type="HOGENOM" id="CLU_1807588_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3A4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="143" mass="16013" checksum="6E80364F825CF64B" modified="2012-11-28" version="1">MAQGAGKLKAAKTSGGRKNTGLTKKGKRNCAPKKAMASKEYMTKKKGWVHGDAVERRKATQVFDQHMVTNPLTSARFDEVYTIELHWNSKTMCDPSADRLKPILALSSQDILPELLQLHNPPEYPADPRRSRPRSTPTLSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V417</accession>
    <name>K1V417_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V417"/>
    <dbReference type="FunCoup" id="K1V417">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V417"/>
    <dbReference type="eggNOG" id="KOG2229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009161_2_1_1"/>
    <dbReference type="InParanoid" id="K1V417"/>
    <dbReference type="OMA" id="AMYKTYK"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="515"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="683"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="648"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="732" mass="81435" checksum="50C363E4C5B84F21" modified="2012-11-28" version="1">MVKSRSARGILVTDTLPQLQNLVKCSQCYPQLTSELPGQLRSLLLGEGGMMMVKGDLREACVRNLVMLRNKDIIDSITLLQTLLPLLPHAGKDLRATVRKTILTDLKTSNQRTKNHRLNRVVQGLLFGMIEAGMGGEVTGDKGKGKQTQPGGEAMWAVMMVRELWRKGVWTDAKTVSIAALATFHPNTKVQSAAIHFFLGSDNDDEEDSDDEDTVAASRKNVKGIEHKNKVKKTGRKEERLLKKAQSGLSHERRKRAEDAGKKVNFPALELLHDPQTFGEKLYDNLQKHDKKYSLDHKILIMQLLSRVMGVHKLCVLGFYTFIIKYLTYHQLQVTLILVSLAQSVHDLTPPDALTPVIRKIAQEFVHPGVGAEVIAAGINAIREVCRRQPWCMEEDLLGDLVEYKKSKDKGVATAAGGLLQLFREVNPGMLKRRDRGKAASMGLIGPGVAAYGHGQDAAEGIEGLELLEEHFAAMRKEANGGVSDDEDAPMDEDDEAGWENWEAESDSESESDGWVDVDSDGGDLEISDSEDEGKPKREKRKRRRGAEESESEDESDDDAKSVVSTATSATSEAKKLSLLAQQKILTPADFALLNELKLKAAQKAVEQAGGTAAKRKLAELERAKRTVTVEEQGQFLTVDEILGPRKKTKADYEERMESIRRGREDREKFGSLKGKKMKDKPSSSTNREKARNKPLMMAVHSNKVMQKKKASLRQKQIRLRAAIDKQKKMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1V458</accession>
    <name>K1V458_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delta-12 fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V458"/>
    <dbReference type="STRING" id="1220162.K1V458"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="InParanoid" id="K1V458"/>
    <dbReference type="OMA" id="IGQHIFH"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="421" mass="47372" checksum="85C70BBE53022D17" modified="2012-11-28" version="1">MSARQRVEQAPKKVTVDAGDLPADRKFVVPNFTNKQLLDAIPLTLVQDVAIVGALAYGAYHIEDALSYLQLDELPTKALRVALWTAYCIVVSFWGTGLWVVGHECGHQAFSTSKTINNAVGWVVHSCLLVPYHAWRISHGRHHAATGSLTRDEVFVPRTRKERGLPEAQNEDEVIGINVPEESQSLLAEALDHVPIAVFWMSMYQLLGFPLYLIMNAAGQKRYPKTTNHFTPSSVIFRSSHKWQILWSDLGIALVLAGCAYWSVKRSFTEMALVYGIPYLLVNFWIVMITYLQHTDPTIPHYSDALWTFPRGALCTIDRTFLGPIGAWAVHGLCETHVLHHVCSKIPHYHAWEATEALKAFIGEHYQRSEENMLVSLWKSHRQCQFIEDGADIAFYKNARGQAQRWGVVAPPEDSGIELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5G9</accession>
    <name>K1V5G9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5G9"/>
    <dbReference type="FunCoup" id="K1V5G9">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V5G9"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_1_1"/>
    <dbReference type="InParanoid" id="K1V5G9"/>
    <dbReference type="OMA" id="WWREQRG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="431"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="758" mass="85507" checksum="A1535B9E7C4E64C3" modified="2012-11-28" version="1">MTRTDRPLPSRRKSSDSFEHVPSYATTPERKARLIYCKSHVAIHPTQLRRDNISGLLGLVEVDKEVPRVPESSGSNSTSGKEVLVVWVPDELFMRMSEEDRRNYKRVEDRPNGAAAEEEAPRGEKYAFSIPVSDLYSLLVYPHWYGSVTFNLAGGVSLPTLFFHDDQTPLVTTPRSSDPPTPPWGFPPFLAVLRQHATVIRSRLVMNGSGEELWLVNPSKADREVHEAGYEEAKRTGDSTPVSYPPQAPHMQYPSLQAMNQASPRDSLLVGLSNVTNIARHAAQNVLNHPLAKPVVPHLPPAFRTLVNAPGEWESTLRPKLGSERSPDVATEFEAARLYLARWARVVAEEGERSRRSELAAQAGQAGQSEDDLTDLGVFSLVSRSKQPAPKPTRDPHHPITVSDWQAFIAGDMDEEFVRGEIFRRGFSDEPSQSQARRQGWEVLLGVVPWNVGDSSGDADKRGAARESVLREKRSEYYKLLTGWQDRARKGETPPDWREEWHRIDLYAVEPEYLGNEEKEAGGSGTSLWGEGNDKEEEGGHAALNRMSDLLSPIYFVADANEADAFWGLCGVMRMMSGMRKQLSTLQQLIQLMDPELYEHLEKTGSLNLFFCFRWILISFKREFSFENVVKLWEVLWTNFYSNNFVLFVALAVLQSHRDVIMRYLSEFDEVLKYANDLSGTAEVLFLSFKQVVQEIDKESAESASQLRQRRKNQAARRTVPAELRELLVCWKPEDSEQAALAASIDALKIDNGDLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5Q5</accession>
    <name>K1V5Q5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5Q5"/>
    <dbReference type="HOGENOM" id="CLU_1732778_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5Q5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="151" mass="16553" checksum="A3953A4FB0F954D2" modified="2012-11-28" version="1">MKARFNCSVPLRHDLGLADMSGHEDVIDGQWERGVIKALAAVKPRSHEATKVRNDMECGPSRAVRFMEGSCEIAMAEDMAERLGYIDQHGPLTTASDGHLTQHAADLMRPWERRERRVLPLASLPPLTFFPPTLSQVPAPAAALSSVLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V628</accession>
    <name>K1V628_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V628"/>
    <dbReference type="eggNOG" id="ENOG502RBGX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1190619_0_0_1"/>
    <dbReference type="InParanoid" id="K1V628"/>
    <dbReference type="OMA" id="GWNEIAD"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26264" checksum="CD740D56F7C2735A" modified="2012-11-28" version="1">MTDNNEKPLVLSTPKQPEELIYNDKSWSDGSLHLISSDNVLFKVPPYYFLANSVVFRDMDESAASTPIHFTDPNIESSTVLRDVLKLFTDWELPADLTGSLDTRDGELVMRVVCIHQFLTKYDCPGPMKTLKALIAAKRVKKQLTGICDFLFCANIDDVEGCDKCSITEGKLSYHLYRHIPGPYFWALLQTSVSLQKTTRAEATFKGHVSIAQLTFANLLRDRDLNASVLVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6B2</accession>
    <name>K1V6B2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6B2"/>
    <dbReference type="FunCoup" id="K1V6B2">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V6B2"/>
    <dbReference type="eggNOG" id="KOG0318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015246_1_0_1"/>
    <dbReference type="InParanoid" id="K1V6B2"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="442"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="558"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="594" mass="61864" checksum="EC372738C94C57B9" modified="2012-11-28" version="1">MSYKPGPLYACNPYTARSESTKLGVDPEGKKLIYTNGRAVIIRDIHDPANAHAYTQHAQTATVARFSPSGYYAASGDVAGNVRIWDTTNPEENILKLAIRPLAGRINDLAWDSESKRIIVGGEGKDKFGAAFFIDSGSSCGEITGHAKPITALSVRHQRPFRAVSGSDDNSIVLHTAVPFKYDKIISTHTRFVRDVQYAPDGSVFASVGSDGKLFIYDGKDGTVLKDADGTDGRSLMALSWAPDSTRLVTAGADGVVALWDAAAAQKSTQWAVGDAVEDQQNGVVWADPNTVVSASCNGVLNVFDVREGGSWKKLYGPTRAVTASALSEKTFYTGSFDGGLKAFSDAGACENVEGQGHSGQIVGLAPDGKGTVYSAAWDDKIAAIKGAEFATTSVPAKAQPGGIAATPNGAYVISDAGLELVSGGSSSTLLSDAGSAVAAHSGSEDLVAVGSGKKVTIYTVSGGKATERASFEDNKGEISALAFSADGSLLAAGDIQGRIVLIDAKSDKVLVSSRWTFHTGRVASLAFNAANKLVSGGADESIYIWNPEKVIRNIAIKNAHPGGVAGVSWRSDNEVISSGADACVRTWTIEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V895</accession>
    <name>K1V895_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V895"/>
    <dbReference type="STRING" id="1220162.K1V895"/>
    <dbReference type="eggNOG" id="ENOG502RB62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877693_0_0_1"/>
    <dbReference type="InParanoid" id="K1V895"/>
    <dbReference type="OrthoDB" id="2573365at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="1">
        <location>
            <begin position="219"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="34784" checksum="0B031C963E08E451" modified="2012-11-28" version="1">MTDLSASVQRELPEIIEHAVTVDCRGTGDMGGVTRAIAAAEAQRTGLTPIEAVCEWWKRSSRDAPLLVHFENPQAINGTTMADIVHVLRLLLSVHSIKTFLSTWPITDFSVIDLHVLSGGRLRKGTSSFENVLRATRKTALQFGGDFDERIGLEEEVVGGGVFAILKTMKTQNPAPRLSTLYALSFPSVFLSGTSDAAWDTSLSEQMRSQVTRQPVTGDIASDAFPELQALFNLWQASGKSVNLWDWLDSFRQVVVPSGVEDGGEHQPHAIDDDIDSRLHALFIRFVEEARLFGTVRARGKNTAKRGDEVVKGVVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8R2</accession>
    <name>K1V8R2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8R2"/>
    <dbReference type="HOGENOM" id="CLU_2575557_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8R2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="81" mass="8997" checksum="486D4B1ADE94F395" modified="2012-11-28" version="1">MLFVTLLTLACAAATPVLVERDTSANVERADALAAVLRREAMTEAAVNFKARTEAMQHQALHEREAQRPRPKQNVRSPEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8Z6</accession>
    <name>K1V8Z6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper/zinc superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8Z6"/>
    <dbReference type="STRING" id="1220162.K1V8Z6"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1442023_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8Z6"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="188" mass="19800" checksum="9244BB02E2C6CA3E" modified="2012-11-28" version="1">MVAPAICAGGIAAISVLKGASNATGHVIFTESEKGVHVTGTITGLEPLSTHGFHVHEFGDISGEGCLATGGHYNPFNQTHGAPEDKVRHAGDLGNVVANENGTVILDITDRQLRLITEEEDGQGGDGIDGDEQLALLKLGHDVVSRDAWRLLVKVRHGAGLELKCGEDICATRTFPLYKSDESPRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9H9</accession>
    <name>K1V9H9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_08318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9H9"/>
    <dbReference type="STRING" id="1220162.K1V9H9"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_2_1_1"/>
    <dbReference type="InParanoid" id="K1V9H9"/>
    <dbReference type="OMA" id="YANVRTN"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="738"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="974"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="316"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC97395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115429" checksum="E8ED80BFC865E442" modified="2012-11-28" version="1">MAQRGPAPPNDGDQRYPRHSHSNSSLFRNASPVPPYAPQQTPTPLSPPSNGHSSLNLNIPVYNPPYANNPPNYSSGRSDASHVSSATYASAFAPSAAASSAAPLLPPISSTGRLPTFERVAAYTRGEAPPVIPPPQGMTPPVMSPAPSHMMSPSPSQIMSPPPHMMSPPPSNMQPTPSYLPPPDQNHPDLQVGFIPSQTFRYAREMREPSRSPSPGFDDSVRYNGRPGDVEQALMGDSNDDGIAPAYRKYDPFGSESALDSGDLGLNGRPNSTYKAPIDDEFESVPLVEEEKETRHFGPAPTGRVGRRNNAGRRIKQKMQLDESGMFQVDMPIPSRLAQFLPVKGVAEQKTTRYTAVTTDPDDFATSGVRLRQNMFNPPRQTELFIVITMYNEDAELFCRTLYGVMKNIAHLCGRKNSRVWGHNGWQKVVVCIVADGRKNVNPRVLDCLAALGIYQEGAMTNKVQDRPVTAHVFEYTTSFALDPDLHFKYPDKGIVPCQFIFCMKEKNAKKINSHRWFFNAFAPLLQPNVCILLDVGTMPGPKSIYHLWKAFDVNSNVGGACGEIATYKGKGWRLLLNPLVAAQNFEYKMSNILDKPMESLFGYCAVLPGAFSAYRYIALQNDADGKGPLASYFMGEKLEGSGADSFTANMYLAEDRVLCFEIVAKPKANWVLKYVKSAVGETDCPDTIPEFIGQRRRWLNGSFFAAVYALLHSRRLWWSGHSLIRKSMLMLEFFYNALNLIFGWFSLGNYYIFFVILTSALEAPQFHAKGIHVFNVILQYIYLGTLVACFIFAMGNRPQGAPWKYKIAIYIFAALTVYMLICGVLCIAVAIENIGSPVFSRMVVSLIATYGIFVISSILALDPWHIGTCFLQFLLFQPMYINILNIYAYSNLHDLSWGTKGSDTVEEDLGHVKVVGKEVEVALVSAQHDIDSAYQDALDNIRVKRAKVDADEVPPKKETKEQKQKDIYANFRTNLLLAWSLSNALLASLILSGGGAGDTFNGSDGNNRTGIYMLVILVFVAAMAAFRFICATMYLIIRLFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9Q9</accession>
    <name>K1V9Q9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative tyrosine-protein phosphatase OCA1</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9Q9"/>
    <dbReference type="STRING" id="1220162.K1V9Q9"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797809_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9Q9"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="144" mass="15432" checksum="FF8A6ECDC35A2051" modified="2012-11-28" version="1">MAKIVPPMNFGLVEDGLYRSAQPTELNFSFLEKLNLRTVIWVGAEEPSDILSPSPTTAARGAADHPRTLAAPASEHIPDPRMLQHGKTSDGHGRWMLAQTAALGALLHPRGVQALRGHEVQFIELFDTDLVSITDGTEGVAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAB3</accession>
    <name>K1VAB3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAB3"/>
    <dbReference type="STRING" id="1220162.K1VAB3"/>
    <dbReference type="eggNOG" id="ENOG502S7CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288723_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAB3"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="874"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1064" mass="110638" checksum="2277EE7D3FD544B1" modified="2012-11-28" version="1">MVLINDKKFACATCIKGHRVSGCTHTDRPLFEVKKKGRPATQCQYCREKRKGGQSSGSVHTKCACGELKNQTPTTIMPGQAGPSGTAPKGSPPVPQKSQPPQQQAAKDTPGSTPNPEIVETRKGQPGSHATYPNGLRDVHEMAAAAEALTGLGGETNQAAERKLSSLLNPCNCQTTGRCRCCAPKRSGRDLLQEHARTKSPNGDSNQVTDSLIEMFKAKATTRSDGGSNSSGSTTPTSGFNRLVNLSMTSASLASPDNRHHPAHTSPHVHKVRLYSPYSNGSSSPRPGKQRSESISSQSSRGGVRPPPPRIRPLSDMNTFLGAVFKEDGSVASEIPRSALGLPGIASFDKAAMNGGVKVESMAMDTDQPVSFPTSEDVVIGACTCGDGCECANCATHGNRSSTSPPNGDHHHHDGCGSKCTSGFDCANHLSIPSGVTSIEHLIQIAAANVPPNPSRSTRRDLNPLDTGVLPSAAHMSEDAAQAFGIVQLRPLECCNGRCQCKPGECKCESDCCGCCESCNCGDDGDTVMGDSSAPSGGCCGSGATETVTSSVANSPSNASASSSFSHRIPSPAPGCHTNIRRTSSVSRAKEVAEGRRSSIGDRSGAAVQRSTSLGSKTAAKTPMALSQTLHPRPILPKPSSSGSCGKGGADRLAPPRSCSGGSRQPSPVHRGSFSSSQSSGCCSPATGPANLQTPNDVSPLPPAATSTDDALGDDPSGGMSVGVNEIANALAASDVDFMSYLNSLLPAATDGSDQQQQQQPQQHQSSDHESSHPTTSTEATGSSHMTSPTDITMFSHPSPRGPNMEQHSIGDIQSMIAGALAQQGMIPRPDTHGEQQVPDYGYLFNMQGGANQQQMQQPAPNAGDASSLYFNFNTGAAGPSHQANALGGMPVPQPSHASDPSSQNPQAYFKPDANIYYPNYGTGYPPNVQIMQPSQGGSHGQQLPQITQQSLASAVAAVAAGNQQQQQHQHQGMPANPDIIDLSKPLNPTDVDRILQALLNQQARQQAVGDAVAPGAVEPAPVPNVPVPPPLQHTPSSSSRQSVPDPATEPGDPFIEKLINNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAP0</accession>
    <name>K1VAP0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAP0"/>
    <dbReference type="FunCoup" id="K1VAP0">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAP0"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373924_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAP0"/>
    <dbReference type="OMA" id="KRTVMHV"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="167"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="525"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="743" mass="83191" checksum="74B8C73B418B0684" modified="2012-11-28" version="1">MSAQYRDPATPAKVITRPRTMFTPRTTVPRPALANHNDNVPPPDSPSRLSPAPGSHPKLKIKSATTPEARQRMLVKPKATPLAKSKFNNVQEEDDVWGAGTNVVAVLDSMEPAPKLDEKETVLVTVRAAELKSGDASSVWSTPDYDNRMIKCLKPRDHQQTQWSFAAMDGYNAVIFAYGQTASGKTFTLTGAPSNPGIIPLAIADMFAQIRSTPDREYLLRASYIELYNECIIDLLSPTGTKELTLSEGKKKGEVVINGLTELGVRSEEDVRELLRRGEEKRKVGTTDWNARSSRSHCVLRLVIESRVRSDNAYTPGRDKATRISTLSIIDLAGSEKHTSSKERNAEGKHINQSLLTLKIVISKLADMAQKRTVMHVNYRDSKLTRLLQPSLSGDALISVICTISPAYINVGESSSTLGFAQGLKRVVLSAKRKDVHDPEALIQQYQNEIAELRALLRQKDSQPSSLSSKSDRARDAEMESRLTELKSLILNSSTVDEAGSQPHVMRPLSPTKVRYQELNYDKTSSKLQEELHLAELRNSELEDEVAQLKAELDIRPKDPDERVVALQQEVNQLRMIASDYERHLREPDRKVREDVEKEWKGRYNQLENRLASKTTWAERLDENLRRTFAEKAALELRCKEAEAKVLAVFEWVTNALDGENGDEYSDDDEESDHDTVGDFGAGAQMNGTNGMSRRRRGRNSSRDWQSEFQSFVGSLGARPPRNKLLRDETVPALASVEDDDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAR6</accession>
    <name>K1VAR6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAR6"/>
    <dbReference type="STRING" id="1220162.K1VAR6"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287881_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAR6"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF390">
        <property type="entry name" value="PROTEIN KINASE C, BRAIN ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="101"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="505"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="872"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1069" mass="115606" checksum="B2EDB49C26B837D2" modified="2012-11-28" version="1">MVSVPYKIPLPASPPPTPPREDLATVTAGAGRTTETSSSAAPKNMSSTSSLSQTAANAGKAAKHLSMMRSAGIPSPDVSRDSCDDSYRSDHVRKLPKLNDFELIRVLGKGCAGRVLLVKHAGTTRVHAMKAISKRAVLANDELDHTLAEQQILKHFAADRRNPFVSRLYYSFSDKENFYLVMEFYPGGDLATQMEIHGILGPLRTRFYTCDIVAGILVRDLKPENILLNWHGHAVLADFGLSKSFGYRGDPIPVKLPADYIEGKGIPPVYAGKGFGSYRNGELTWDRAYSFVGTQEYLAPEVIKRNHYTYAIDWWALGCIVCECLTGRVPFRGHDDESNAELYERVINSRWDAMYRGETKPRSYLKERYRIDSTTYDFIDGLLQKEPMFRLTEPSVKVHPYFTNVDWATVDKGDYQDPFQLEINPVAEYNTQFFPRLCLEETPTVDMTGHDYGRDSDREQSPLNSDEVYARVQAEFAKELESFDWTCQDYELEDDVSDIAEDSEFALSEDESEDEPVDVEEQVAVPRSHSATDSEPQPVSNATASIRDSPEPVPIEEPVSAEIETTPQPPQQPLVQQVDIPVESSPSAPVIPEEPAQPMVESPVTAMETVHEDAPLSVTTVTTPPPAPAPPVARVASTSSKDASPDAPSIKLPPIDALGIRTTPAPEQSTVQPGDITISQDQYLNVRLPSGPPSSGLSVSDVISVPSPHQGSPNLLIRRHRHLPSIDRVNQRLSVDLGGTFAQLGDEDWEQLDSRKIPEAVNGANAAGQTYSRFARGLGSVLGRRPSSRTGGLRTPSMSVRSGLRKSVTTSESETDQDLERSPGGKTRSPLFAARGVENTKRVFGRIKAFPPSKRTGHDPSRLSARSPPTVHSAMPSATPSATHSAAPSATHSQSPSSSPSPVGSIRGVAPVAGLVIPSSPPTLAAPLPITTTAAPPPSSIAATASLVASPSSTSVEIPRLKRGGSLRADPASKRSSIVSAFSPGGKRIVRSGSEFNFFSKPKGRTQMERTVSERNPKAPATAPTTAPGSPGATSDSTLSAASASSVPRIELQPTPPIVWGLELNTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBS9</accession>
    <name>K1VBS9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBS9"/>
    <dbReference type="HOGENOM" id="CLU_1587659_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBS9"/>
    <dbReference type="OrthoDB" id="10660982at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="168" mass="18333" checksum="CD5F3E275650815F" modified="2012-11-28" version="1">MPLGGLLRKRRRVDPADEVTKEKKNWMAIDRTVAPLPASALPSSSTSASLPDSTPSRAPLAPVQGGTPIAVDQENLPEGLEGDMLSRLLELNTEHTRLQMLYEDLYARYSMQKEQLAEASEAIEELGAAVEKRDARIRVLRMTIRRLKGGAGSQQGRQQFPEGSAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC27</accession>
    <name>K1VC27_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC27"/>
    <dbReference type="STRING" id="1220162.K1VC27"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031650_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC27"/>
    <dbReference type="OMA" id="CEPNVRY"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="90"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="53948" checksum="0430C0D032D9ECA5" modified="2012-11-28" version="1">MPSPADEELAAAVTAVRAAHPDLGIVKLWGALKEAHPEWTVSEKRFRKVLSSLGGTSNASTSMPAGKVAEDELVAQTGLDKTLDIPSLAPKVKAKLFGGTKGKGLVARSKLEQGEMLWQEEPFVATPDPKIKEYCRDRTLCTHCLALWAPPPPTVVGCKDCSDAFFCNRLCMSRGSSSGSHHVLLCEGVNPGAAKLNKFMKEREWRSMDAVARILAKWRGERAWGEEGAAEAIEKRIWESMARMNMRTREEGKEDWPKRSAQVESQWRDGHAALVAALNPAPSTPGGKKFNAVLQSRAKGRKIQPLSEDEEARWFSYDAFLDLLGLVNINLEDSGGLYALHCHMNHSCEPNVQVRNLPRHWTPPTSLPAPLPDANPRGVRGTHKLTMLARRTIHPGDELTVSYVDFNLPRRARRQALRDGYGFWCVCAKCTREEKEEETERKRLREEREAKAAAKGEVKETKEEGKAQLDDVVAKMEELAVDDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCE4</accession>
    <name>K1VCE4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCE4"/>
    <dbReference type="FunCoup" id="K1VCE4">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VCE4"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_3_2_1"/>
    <dbReference type="InParanoid" id="K1VCE4"/>
    <dbReference type="OMA" id="RDYTEMN"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="190" mass="20715" checksum="0F035EDE90FE975D" modified="2012-11-28" version="1">MSRRLATFSRHLSTSSKASSSPDMFGAIKSKLGYENLPADAGNKSFYDLKAQLPGQDKYLDFSTLKGKVVLIVNTASKCGFTPQLYKDYHDRGFEVIGFPSNEFNGQEPGNDEQIAEFCQSKVNGPDMNEVFAWLKSQNAPGAGGVAGTTSIKWNFTKFLVDKNGKLVDRFGSTTTPASIAPKIEKLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCF4</accession>
    <name>K1VCF4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response to unfolded-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCF4"/>
    <dbReference type="STRING" id="1220162.K1VCF4"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399663_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCF4"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="182"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="689" mass="75482" checksum="082680AB727E8C1B" modified="2012-11-28" version="1">MKINGSFFQPSPPAHQKWRSSLGKHIVSTNLSSSVETRIPGMSADGYTEEERAAAYYAQQGYDEATIAQMMGGSYGAGASSSSAAGPSTGTVPGYDKDGYKIKTTIPESAQNAPLLDADLLKTTYMKPIKPDDPKKSGGSSSSSNPNKIKYNTPGKRETVVRKGSGRVWEDATLLEWDPKWYRLFVGDVSNDVSERTLDEAFNKYPSYCKCKVVRDRLSQKYGFIAFKDPEDFLRAWKEMDGKYVGNRPIRLTKIKEDKYGTTSKQTISARKTPSNRTNLHYYTDARCSAVATPLAILGPANFESKSFPTGYAGKHLAPPRLAPNHLPPPPSTFLPPPLPPSTLTMPATSSFKTPSSPARARSVSQPLREGVDDVYRHIGEANSPRNSFQRSISSHPTVGAHGRRDSNSALSRLPRPAAPVQDRSSPLLRSAATSPTTSTTGLALRTTTLLGSTLLVSTNVTSAKRLRSFAALIDTAVPFDSSRRLYQRMISCAFWRVLIDAIPGMTQDVSWTIVNLGYMALSFLMFHHVTGIPFESNMSTGGAYDDLTLWEQIDQGAQYTPAKKWLTSVPIGLLKAREGGSRARATGPRPKSTGWSDLRSTTAPSQPDRTTEAIDPDTEPTLTCSFLISTHYTRYDYTLFALNFAALIFVLFPKLPLLHRLRFHFLNFDGGPTPAPSRPASPGPSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCG1</accession>
    <name>K1VCG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cwf15/Cwc15 cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCG1"/>
    <dbReference type="STRING" id="1220162.K1VCG1"/>
    <dbReference type="eggNOG" id="KOG3228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132927_1_0_1"/>
    <dbReference type="InParanoid" id="K1VCG1"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11816" checksum="13189EE1D07272F5" modified="2012-11-28" version="1">MAELAKIKRERAEEKARLAAEADAANAADRDAEIASGNPLLNLQAALGQGPAESSSAGGGGFAVKRRWDDDLIFKNQAVTLDKPKKGEFVNDLLRSEFHKKFMQKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCG8</accession>
    <name>K1VCG8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase I subunit RPA1</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase I subunit rpa1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000388">
        <property type="protein sequence ID" value="EKC98500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCG8"/>
    <dbReference type="STRING" id="1220162.K1VCG8"/>
    <dbReference type="eggNOG" id="KOG0262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146885_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCG8"/>
    <dbReference type="OMA" id="SLTADHM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="149" mass="16097" checksum="FB5FA8BF88382E66" modified="2012-11-28" version="1">MPPPPRLFTSSLPYELADELIDLDKLGSNDVYAILRTYGVEAARRSIINEMSSIFGAYGIGVDYRHLTVIADYMTHHGGYRPFNRTGIASKSSPLLKASFETTVAFLSEATLHGDFDDLTSPAAKIVMGKPSGSGTGAFDIRAPRRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCW0</accession>
    <name>K1VCW0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCW0"/>
    <dbReference type="STRING" id="1220162.K1VCW0"/>
    <dbReference type="eggNOG" id="ENOG502SEME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824359_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCW0"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="237"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="36229" checksum="DF7BC8442B611C97" modified="2012-11-28" version="1">MGAGLETAEEEQAEPDKVDKPEVGENPKEQPPVVADDSKKHGLGLINGPDASAEGRPRPTSKDGKLPGSNRSSTGSKSGSAPLTPATLAALNALSLDESGSATPRATNPALVAEAAVSRRVKVRDYAFHMTDLRFVGLGPHRSRSNWSEGEPEPSTPSAPTSQEGWGFSGFGFGASFGPSSSSPSTEQPSTGLSFGLGSWTKRDDEDVADHSASDYWSEDEELGPDDIYYHGGDEGEPDGLYRTAYPFYPEGINEIAIEVGEFLDVRGRGGGEGWVVGTRLRDGVEGLVPEGYLERCSEADPELDAEWEQVRQMRRQREQTPESLSGNSENDEKERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE99</accession>
    <name>K1VE99_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transparent testa glabra 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE99"/>
    <dbReference type="FunCoup" id="K1VE99">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VE99"/>
    <dbReference type="eggNOG" id="KOG0290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013694_1_1_1"/>
    <dbReference type="InParanoid" id="K1VE99"/>
    <dbReference type="OMA" id="TIAMDAC"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="44555" checksum="902A69380FE08A12" modified="2012-11-28" version="1">MSLPNVLTYDASRNNDARHAHRVALTSFNTGPSNKLTVVDLAPQHQHQPGSAGYGGQGGQDFTQLASANLAFPATKVAWEPSSSIGRHDGGALLATTGDVLRIWELTNGENDPTPAQSRIGYGSRNGYDASYKLSERSVLSNARRVAAFAPAVILSRRANPQSKQHICNLPPITSFSWNPTAPASIVTCSTDTTATLWDIHTSTALTQLIAHDRAVYDLSWLPQSAEIFVSVGADGSLRAFDLRQLEHSTILYETPNSAPLARIAFSNREQHQLACFSMDDSKTLILDMRSPGQPVAELLGHSAPLSAIAWGNGGSSVGESGGGWIASAGDDGQILIYDLTEKIPVEPKAKTSNGPYALSPAVGETPTRTPSPANNAVEYQPVRAWNAPAEINNLAYSRDGDWVGAVSGQRLSVVHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEG5</accession>
    <name>K1VEG5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEG5"/>
    <dbReference type="HOGENOM" id="CLU_454309_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEG5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="601" mass="67087" checksum="F73A81B38D448B0C" modified="2012-11-28" version="1">MGAISNVNHGGAIARDIPQDAYAQPLQARSEPEEVRRSGISADSAIQARGGDSECSSVFFFNAPPGSLMDKYRQPAGCPYGIEKYTDELRQKDVDNGFNIPEPDSKNWGEDSDIRLVNPIGDIYDYIRAIKNGELVDTSLDPNVVGNVGKWDHDPSKQPGSKVGSGVKPQITNWKDQEAKGWKRGGDFGGHGGDGGKTAQGGKHINNGGSSSSSSSSWSTSWSYSWDYSKSFDANWSECCKQFECFKENSHKKDDSGNKRPAECDLGFENGFKRHLWWDFTKSFDDNWKFCWGLKACEDYCKQRNEPAPGKAQPGQNPDQDKGKGHGEDKSEDDRCNQLNAVGYPPGSVEDRYRQPAGCPFGVDKIPEVKAKEEAEKKQKEEAEKQQQQQQQQQQQQQQQQEAEKQKQEAEKQKQEAEKQKQEGGGDLGSKEGETCAQCRQRQGIDKETTPDWRFGCAGCIDTDDDKGTCWGDNCGKDHGDKGKQEGGGDLGSKEGETCAQCRQRQGINKETTPDWRFACSGCVDTDEDKGTCWGDNCGGNPGKPPVGGGEEPRRQGRLHHWHLRRYRRRQGTPGRRQGRLLDWQVRRWCDRQGPRRRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEW6</accession>
    <name>K1VEW6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEW6"/>
    <dbReference type="HOGENOM" id="CLU_302716_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEW6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF12">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852107" evidence="2">
        <location>
            <begin position="19"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="985" mass="107790" checksum="7D2712B6822D5F8F" modified="2012-11-28" version="1">MQLHKLLPLIVYLGTATAAPLSGDDSDAGAGFASGEGSGLEALRNAKIFGGPDIVMKGPILPKRGEHKSDEDGDCDDDDQAEDDGDRNAERALDESLMDLMARGKSSSGSTGGKVSQVASTLGGIGSAIGGISAVGGLIHSLWNHHKEKEQQGQQQQQRDLHDTTAVDLTEFPPEVENELKTLYGRDLTLDERANWGNIASNIGKAGSAITGGFAILDLARNILGGHNDKQQRDLNNVEFTAEEEDQLKSLFGRDLTFEERANWGKIASNIGTAGTAISGIAGIGGLINQIFNSDKGQEQQNGKRDFVTELSPEVQDQLNTLFGRDLTLDERKVDWDHLGSILRIPNLGLGLGPIPVGGQQDKQQDGQHQNGKRDFQGTELSPELQDQLQSLYGRDLALEERFNWRTGLQVVTGIAPLLPFVFGNRGGDDKQQQQGQQQDGQQQNGKRDYETTELSPEVQNELKTLFGRDLDLDERGWKDVLRWGTRLAPLAPLVPLVFGNHGGGDQQQQQQQQQQQQQQQQQQGQQGQQQDGQQQNGKRDYQITELSPELQDQLNTLYGRDLSLEERGLGGLLKFLGPLSSIIGLADGGNDKRDFQDEISPEVEDQLKTLFGRDLTVEERGLGGILKFLGPLSSIIGLADGGNDKRDFQDEISPEVEDQLKTLFGRDLTVEERGLGGILKFLGPLSSIIGLADGGNDKRDLQAELTPEMEDQLKTLFGRDLAVEERGLLDFFPVIKGLLGGFGGGNGKRGFQDDELSPEEVENQLKTLFGRDLTLEERGKWSTAANWIGGAGMAAGLINSLLPMFQRKDDKQQNAARGLQGGDLSPEVEEQLKTLFGRDLAFDQQRNAARGLDERGKWENIKNVGSFGWNAYRAADQLFPNEVEGVKDKVKGLFSRDYLEEEALADLARLNLQERSRLKAFKGLGPGPLRYPGMGQPDMGKLMDQLLHQKPGKRSYDATAQAWEQELAEQLRAGLSARGLDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF72</accession>
    <name>K1VF72_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF72"/>
    <dbReference type="STRING" id="1220162.K1VF72"/>
    <dbReference type="eggNOG" id="KOG2810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538826_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF72"/>
    <dbReference type="OMA" id="IATTICT"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="506" mass="54861" checksum="39C6F45CF16A219E" modified="2012-11-28" version="1">MTRPGTRPHAVNEKMSSGEASTASFIGKASAVNEVERIDLRIVDPQGGLKANTQADDGEDDDVRVHELSARLEIRLVYHHGVVKKHNLHLHASQFLRVIVDPDSTPSGFQISARELKDWLEHFSIAFGGSSNPNGAVKGDSQLAWRFGQQEVRVKNFDNGPSSSLSTEIKLNVGEFKDYGVYHDDGDVDLALPMREFKFVMDLDIRFSEASQPLTLSSMYIGDDRYNNEATLFEIFCAIATTKCDAFNDQPTQKKEAAAAPQSTSASTRQPSIASSRERTASVQAPANGSVDPRSRRASATLLRPSGSNRPSRLRASLSMTSEAPHAATQAQADPEPLFQSGGSQSIRLTQEEVLEMAGLNFEDMDMAMDDADLDDEAGGGDDGGAGHTEDNEVPSGWDDISFDNLPAENMSTQRQQAQRAAQAASQANIPEAPDHPGGVDALPERTGSAAQGQFEPDDDIFGNDSAQNIKAEPVEEEGEEEELEPDELDPTQDSSGRKFTSFFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF89</accession>
    <name>K1VF89_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetoacetyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF89"/>
    <dbReference type="FunCoup" id="K1VF89">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VF89"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="InParanoid" id="K1VF89"/>
    <dbReference type="OMA" id="VIWVNDG"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF129">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="242" mass="25169" checksum="960F5A5E4BF019F8" modified="2012-11-28" version="1">MAKAQAYIVTGASSGIGAAIALALLAKGNTVINIDRKAPTSPLPNLLSYVADLTNEGQVKAVAEQIVQSYSIIGLVNNAGATKPGTVDTQTTDDLDFLCNLHLKASLVLIQAVLPSMREAGFGRIVMMASRAALGKTNRIAYSATKAGMIGMARTLAMELGKDGITVNSLAPGPIATELFMQSNPEGHPNTQKIIDSIVVGRLGTPEDVARAAMFFLDRHNGFVTGQVLYVCGGTTLGVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFH0</accession>
    <name>K1VFH0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFH0"/>
    <dbReference type="FunCoup" id="K1VFH0">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFH0"/>
    <dbReference type="eggNOG" id="KOG4035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017272_1_0_1"/>
    <dbReference type="InParanoid" id="K1VFH0"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="297"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="655" mass="72863" checksum="FC46C2B057648503" modified="2012-11-28" version="1">MPRDAHSHAHRVAAYPAHAPKRHHGDERERGERSSSPVRSSSLRRRGSANAAAARRNGASSNGADHSHDFSYDLTSDPESSGASGATAEASSSPSHKKPARSATQMAGEDLYIRLNDREDFWAELEALLELPEGCDLVMLDNTIRMFVTICGAYHDRYLRDQHEMNVAIDLLLSSELFTYYRERMVGIMMGDAQEASEPFPEPQEVVQAAADAGRGRGDGLRGVARHRSPARDPADTQNFILGLPSIETRLRLPATNLMYEVCRVQRLNESELAIFDDRFIDHLFDLVETTRNNQDESLNWAVIRLICALNEQFMVATLPKKKVNTASTRDLPSLAEHDSPERAVRTRAHSASPAPHSQVLEDDGKKHNRVLVVLMRRLGSSKTFGENVIFMLNRSENTQTGLCLKLLILKILYLLFTTEGTSEYFYLNDLRVLLDVFIRELVDLDEDHEALRHTYLRVLYPLIAFTQMKHDPYKREQIKLVLRSLVGNQHFKDVNLTTKRLVERCLRQAEAPLEELCLGSVKDALLSSGFGGPGEFDSPVDVEAGSSPTLNRTAKEKKVGSMDSYEATTRARLGVPSSGPIRNSSLVDLSKTLEERGDSVTPLDRSQTNTPTERKPRRKAPAPPAAKRKHSVTSTTSSASVVSDGPSGWITFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFT4</accession>
    <name>K1VFT4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06044</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFT4"/>
    <dbReference type="FunCoup" id="K1VFT4">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFT4"/>
    <dbReference type="eggNOG" id="KOG3790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018580_1_0_1"/>
    <dbReference type="InParanoid" id="K1VFT4"/>
    <dbReference type="OMA" id="IREPNIN"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="609" mass="68473" checksum="4D85907DBE4A04E3" modified="2012-11-28" version="1">MDGVTNGLASTRLDSGSPSVPSLQPKAPAKPVKATVQTPPRPKFKPTHLPREHTGPLDIETEKWVTPLSAPAYFPLDIFHSILNELSRHPEQNSSLIIRADCLPSQPGDDDDGGLGERLGLEMNEFNRFRFVPRQPNRDSRLEQVIHTYSAPDGSAGLHVKMPQADSAAEVPYYHPPVRKLAFQWQAAEETEAAMPGEGVPRVYGTLTVSYLPFDDTPSTGNPELMAPPPKVPRRRSPLAPPLPEAAPVQTPATVLEDDTPEARIEAQAVVERRLNRTCLALLEKLHKHGYGTLIGYQKRVHHDDLYQTLKERHKKLDSRVPLAWSTKVEDVKRHVWKNPGSPDDRALPDDLSLWGSQDIAICTFLMLLWKDMYPPREGPAITGQEWDTWGRPPAGFIDLGCGYDGKGYELRARRTWPEYPDKTQAALIELPIDMPSWFPETLEQWEAGEWPGREDCVIKPGSFMLGNHADELTPWIPLLSLIPAKPVPYLSLPCCLHTLDEKFTTLEYKAPPHTHTPEGGFEVGLEAGSSRYKSYVMWLGWVGLQCGWKWEKESLRIPSTRGWGIVARSRWTTTTEEDQACRKWALDEVNAVRERGAFKVRVKEGKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFX3</accession>
    <name>K1VFX3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFX3"/>
    <dbReference type="HOGENOM" id="CLU_2225043_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFX3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="106" mass="11768" checksum="70F2D35DD2168921" modified="2012-11-28" version="1">MAENAPLIPPDQPIDPKRVPVRVHPLDRGPVINCILKMTSPIGKLRDSIAARQGIERDAFVLLYDGHLVYDNDTLESLAEYGVDEEEIRAGVRFEMNARQIGGCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFX6</accession>
    <name>K1VFX6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD03000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFX6"/>
    <dbReference type="STRING" id="1220162.K1VFX6"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217236_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFX6"/>
    <dbReference type="OMA" id="METVAYR"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="216" mass="24027" checksum="FD649DC4C02E3C0E" modified="2012-11-28" version="1">MSAAELAFAQVQEDKAPAIPLSPEAEERFNRITRNLQEVTSGDIIRKVLSDGETPRLYWGTATTGRPHIAYCVPLMKIADFLNAGVHVKILLADLHAFLDANKSTMEVLQYRVQYYSHLLHAVFTTLGVPTDKLEFVTGSSYQLTPKYTMDMYKFHALTTVKAAEHAGADVVKESESPLMCSLLYPGLQALDEEYLDVHIQFGGVDQVSSERTDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGU9</accession>
    <name>K1VGU9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGU9"/>
    <dbReference type="STRING" id="1220162.K1VGU9"/>
    <dbReference type="eggNOG" id="ENOG502RW1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_6_1"/>
    <dbReference type="InParanoid" id="K1VGU9"/>
    <dbReference type="OMA" id="FARRYHK"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="248" mass="28805" checksum="A3BB403251C00820" modified="2012-11-28" version="1">MPRPRLTTPERVAIAATAEFLTPRSSQKRYGVSRSSYFDFKKRYENGSPLRTKSTPGRPPKVPEPLWPKLAAFARRYHKVPLHKLAKQVKPVCGTTMSVNTLRKYLAKTDMKRRRAKRKPLLPPRIKILRRRWIREVAKVNWDAVTWTDEASVALTQDGPIYVTCTKEERFHDRNLAPAIRKGSRLMIWGAIYKGGRSKLVRLEREDEQEKRQRKGKKKSKKRRGITAQVMIDSVYKTELNREAKGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHY9</accession>
    <name>K1VHY9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHY9"/>
    <dbReference type="HOGENOM" id="CLU_1042768_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHY9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="267" mass="27805" checksum="45617C0D16C85EA6" modified="2012-11-28" version="1">MTTVKPEDLPIGPITRIVPPASLAFALPSPSVSSTPKKNNKPKIIGGVIGGVVGLILLLAALWFLLRWKRKRSRTKRGHAELGEGADTDTAAPTPQQKHSEDRPQIAQVRGAVTVPTPAATTTGPRTKEALAPATELGSLPSGTTQPLNNTTRTTNGNTLDDSLRSSIHDTLSPLPNDVLGPSPAASPPGSSLGHGSLAVPPGHRPDSPLSISTLRHARSPSLSSVLSDYVDASEIAKTPISASEYMRRGIGGTGGDSEVNWRCAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI04</accession>
    <name>K1VI04_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI04"/>
    <dbReference type="STRING" id="1220162.K1VI04"/>
    <dbReference type="eggNOG" id="KOG2999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009191_1_0_1"/>
    <dbReference type="InParanoid" id="K1VI04"/>
    <dbReference type="OMA" id="CPHMKDL"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="398"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="834" mass="93422" checksum="E7C451D47BA050C9" modified="2012-11-28" version="1">MVDQQLPHSSPGKARSHRSRGSRASNAGSASSSPRISSSTTFQSGKNENAIPTNVITYKGRRIPARIDPDASAVRARRRRNNQSAAETTNDQSILRVVEIMAKSFNAPEHHVALALRDESDNLVTQANIAEKVASRETLKGIKRGCCGALPKSENSQIPEDTGTLPAKLALFNLQKYIKEDDFAVEFMLKGGVKFLVDLITDEGPRILTGNSLAGIRGVMDYDNGWGNFSDAFIDRVIRILASSNVTNVVRPATVIIRKLVNASPKGHNAKGKSKAREDDAVNNYGFERIFGRISEAGLQIDDGQVGPGAERVFRPIVKRLEVQRDLELVSQSLALINACLRSAQQEGSKRYSELISVIETLGTRRHVAGRILDFQNRYANVLRYHSLRPVRPATNTTHERYLSDIWNAGRLDDEEATASSINISSTRISSPDYHHSGGPRSWEGWRRMGLSLEFADDSEELNETELFRSVGELGLECLHYYAMHEENFHSVVLEQQARPEDRRCPIGRASAECVKVLYDHYKISQSASRGSSHFQPFMLNFPRLHSLVLKFFLRMWQDSESRLDDFERLSYLVTSQVRLTLANEHTKTWLNLENDFLGTDYRNIRDGQMEMIDKEDGLLERPAVNDLREKVRREAYEVVSDQRLLCMMQGSWFNAAHVLVPGIEQASRPTPSKPLRFVRLSQDQQTLHWGEFVERSTVPPSYEQLKYKSGSAYLLLADPTVDLDDVTEVHVQTGCAIGSRSPDLVSKLSISLMSGPNLSLLDIDAIHAQQFAEWTDGLLVLKGQSEMGTQESNNYVHLALKIRLLDITGDGIEIPQRVNFGNAPKSTDFWFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJD1</accession>
    <name>K1VJD1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01526</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJD1"/>
    <dbReference type="FunCoup" id="K1VJD1">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJD1"/>
    <dbReference type="eggNOG" id="KOG1189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="InParanoid" id="K1VJD1"/>
    <dbReference type="OMA" id="YHINTIP"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="13">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="14">
        <location>
            <begin position="477"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="748"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="869"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="873"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD04180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="960" mass="107844" checksum="2EED3604DD877749" modified="2012-11-28" version="1">MSDVTLDSNIFFDRAKKIFDAWENPSGDTQELGDVSALQIFLGDATDDAPTLNKSAALQILRRLEPKNGIEVDVRVRAPKDESTANVLPDLVLELGDSKVGYLPKDKATGRLADEWNKARQGRRRDPARLTSTCMNNYFKSKMEALIDRGTDITHENFSQLVEEKIGNDEKGADMKLWNKNSDLKDVDFTNTDWVYSPIIQSGGQYDLKVSAYSNENKLKPGVILSSLGIRYKSYSASMARTFIISPSQEENLKTLLDVRLSAVKLLKDGAVAKDVYNEAASMLQDRGLGDAFVKNIGFAYRDSTFLLGPKNERKLKENMILIVTLGLADLSDKKGKYSLMLQDTVKVGVDGGSFLTEGCTRIADVVMDFDDEDDEPAPVKEKKPVSKSSNGKVAKAPAASTRGASTKHTRGAQREQIESTTAQRIKAHQSELHAQRKADGLKKWANGGTGKGNDNDKVVKRYESYRREEQLPPNLQDRRSIILPVNGFATPFHISTVKNVTKVDESDHIALRINFQSPGQIAGKKEDMPFEDPDATFIRSMTFRSKDHRHMLKVYDAISGLKKAATKREAERKEMADVIEQEKLIEIKGRHPYVLKNVFPRPATEGKKSDGNVEIHQNGLRFRPDGPGAKIDLLFSNIKHLFFQPSEKELIVLLHVHLKAPIMLGKKKTWDVQFFREVSDMNFDETTGKRRKARYGDEDEIEQEQEDRRRRQELDKVFQVFAKRVSDAAQAQQYELEVDVPFRELGFNGVPHRTNVLLMPTTDCLVHLSETPFTVITLSEVEIVHFERVQFGLKAFDMVFVLNDFKKSPIAINSIPVVHLDNVKEWLDSVDIPISEGPVNLSWPAIMKTINEDPYAFYKEGGWEFLTGDGNSDSEDESSEGSVFEDDESAFDESSSDSDSDDYSDEDSDDSGSEAGFSDESGESWDALERKAKKADDKRRDAGDDLSDDDRKKKKGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK68</accession>
    <name>K1VK68_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK68"/>
    <dbReference type="STRING" id="1220162.K1VK68"/>
    <dbReference type="eggNOG" id="ENOG502RSBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802122_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK68"/>
    <dbReference type="OMA" id="ININMAT"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="346" mass="36857" checksum="EF6EFD3D62AF5A18" modified="2012-11-28" version="1">MQTNKPAITLDTALANSTLTNSPLTTQSANTTPNTSYTPIMPGESSTRRQRIAMACQYCRHRKIKCCGSTPCANCTRARRSCDYQPVPEEVNRATREKKAAAKAAKSAFVSQRAAPYFVGESPMYGMSYLGHGPIRGTHVPARRSYSTPININMATMSPYSPVPHSAPPMSSPAQFEQGWFNAPPVPVINVSPMVPIVPAVEAPMSVPIPSVPTLPPSVPDHSVEDNSAYATYATAPVSPTESSASTSYAMPVTPTPNILTYTPQPFPFSPSPLAQSAFASSPTLCPGLPVPQQKQQPQAPQQPLVGLGIGLPGPGDEGVYVSNVQGNEYMNGNVWVQPDASPYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK72</accession>
    <name>K1VK72_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK72"/>
    <dbReference type="FunCoup" id="K1VK72">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517948_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK72"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="526" mass="57668" checksum="6F00CE18F5880E3F" modified="2012-11-28" version="1">MVLLRQSHRLWPAPRPISAFRRQPTFASRFSHHDAFKPDPLERSTSDDSVLPLEPPSPPEPTRSASSVDSIPDFPARDERPPEQRPSGSRSTEPSATALAGNVSTHSAVLQELLKQQRDQLQKEKDLQKEEEQLQKQAERKVKPFDLLDRRKEEDSGRAVTWADPVSVAEATAAATATATATAPSASLSMPSISTEEFKKRLAEWKTALDKKSRELAQQADKNFSLLGLRVNEVTGYREVELLKEAVKSRGASLTADVALTPEREIEGKRKNVREAKVAYETAVATLSKTQQDVQALLERKHTWSDHDVAHFTQLVRSDHASKNAVETTSQQLKEAELAVDTAFTALMQSILERYHEEQVWSDKIRSVSTWASLVVLGANLIVFVGAIAFVEPWKRKRLVEGLEERMTGMMTKVDSQLQTLSDRVGSLEPVSSSVLAAAPVAAVNSEVSPKEDGVNHISPSPIHTLEPHLSTVPYGSEAFAWSTDSLDKLAPPSAERDLAAAAAVGAVAGAVTISLISFIASLIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKB9</accession>
    <name>K1VKB9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKB9"/>
    <dbReference type="STRING" id="1220162.K1VKB9"/>
    <dbReference type="eggNOG" id="ENOG502SHMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542040_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKB9"/>
    <dbReference type="OMA" id="HRVWHRS"/>
    <dbReference type="OrthoDB" id="2532648at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56274" checksum="4057E75F1FA5867B" modified="2012-11-28" version="1">MSDHEERKIELLDLPGELLSQIAGLFMDVLVRASPRWILERFEIGRWRDHVWEEAFRRRFLPSWVRYKNADDSWRAAYLRVLGRLEHRSVGCAHHESWTSNHAHYPTDVRVVLHLQDVRILALGVLVERPSWCANDSAHLVLHPPMLRRLHTTPRSPRAPPRLPRTTSAPDEQHNFIPLVRSTTGSSAPNPPSIATSSPPSRPPALSSSPSLFGSFGDWMGRARRLSLHAEPENGPSQPRAGDRERRWSLPSLTRSRSHPNEPTGEPHEASSSAADQAYQPPDPHASSPLFAIHGASPRVPTLQLMPALPEDHTPPTPPTPSPPPQLRVQRPYTPLTHPTPAYSHRLYPNFTPYESEWLRTTSYSVDRLNPGLGVTPDDDPVLRVRDFRADHEETSEIGETSSGKAMWGTEGMKVTEPLHRKLTDRLVAQLFPGTRNEAAPPGVPRDAAVEGALVDLGPRGQYASLGWEDLEVLLPWVKLKSPGHDDHDGRRSGWGFEAGTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKG7</accession>
    <name>K1VKG7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000217">
        <property type="protein sequence ID" value="EKD04635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKG7"/>
    <dbReference type="HOGENOM" id="CLU_2251937_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKG7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="104" mass="11624" checksum="8055A65F1B65947F" modified="2012-11-28" version="1">MIVWTAKMLSERVQPVAAFPAPPAPQVYESGQESRHEPGQDQTTPDDEIWDSASAQSAPAAFRSPLASERRSRSPTLRRRGLGTPSMRDDELPLHRGERPRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKM1</accession>
    <name>K1VKM1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKM1"/>
    <dbReference type="HOGENOM" id="CLU_021222_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKM1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="759" mass="84262" checksum="259D306EBB5D4D98" modified="2012-11-28" version="1">MLALAAKSSDAVTLQFDADFENRETLHSFLVLVTDQTFDADGFPFGDYWEWRWSLHHLLQFLDKWGCERCVTTLRSIGSAAILRDELQFANAFVFCALLNDLAACRGAVLRYARNYADHPGQMGEGLGHPALIHGTQRESMFILGQSPYEVFCVLPQAYAYALLRACVDFEPYSDDNDEVERFADKFVQVATAALEVERQQPIQPTLKQKSNPQPQVAGMAPVKSHRSPPRREARTGLRRSLLRPPATPPVCPFGTPPPDTRDPIYTPTYSPPDSPTPNRTAEPLLTESVWQRVAAVFRGPQPAPTPPSRSPSPPPELQSEPEQRVQNDSLPVGDPGQPSALYIPPPDAWAELRARLTGLPEEEDSEMSSDVTSSSSDFGNDVDSTPDSASVSSTSSSLVPASISEGSADEVEHELSPVRYDTGPPPAYVDDSADTFLFMGRAQPFDLSTSDDDLMRDGPLVRGEPRRRLRFMTRDGADGEIRKTLVAAYFPPLAAKRPNCNGSYLIPGAESAVVYIAFGIVLKPGILHELVRDKDAEGPVSDEERVRIAQRWTKTLQFFTQWASERGVKRLRTALHIMVHHAPDSIDAETAFVLACQANCVAAAYDLLVEYRRVSFVHSGTRNSLFARALRAMPEDCAERTLPESWNKLLPKPYRLAVQLAGERWNPITHGKKFARAFITLSLQLVYATGQKGEIHFPRAFAVPDSEAYGDVRTVHDARLLRRVFQVVGLRVSKRPNQSGTYLAPGHPRFYRNNAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKP6</accession>
    <name>K1VKP6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKP6"/>
    <dbReference type="STRING" id="1220162.K1VKP6"/>
    <dbReference type="MEROPS" id="A01.078"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432920_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKP6"/>
    <dbReference type="OMA" id="KRWAILP"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854190" evidence="9">
        <location>
            <begin position="17"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="172"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="545"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="645" mass="68324" checksum="DDB4EB5AF551C404" modified="2012-11-28" version="1">MLPQTLFLIVAGLASASPFAILPDTPDDEVAAIQGARKRWAILPDTPEDEVAAVQAGKKRWAILPDTPEDEVAAVQAGKKRWAILPDTPEDEVAAVQAGKRQLGAVVNLHRTVSHHGNAKRDPHHALTRDAALCDVRYNEGRNAKRFNEELTRLQKRAGEMGMVNHEYDNLYTGEISVGNPGQKFSVVLDTGSADLWVQESNCTKCQGSKYDRAQSSSFSVPDGSPTFRINYGSGSVTGRLGRDDVSLAGYRVVKQTFGLIDQGSHILGDNGQGILGLAFQSLSNAKVTPWWVTSSTKWPQQIFAFYLRRWRHDDAATGSDDGGRLTLGYLDNSLYQGDVHYVKLLDNPKYWAVPMSKLSVGGQDVDLSGKPNVAIDTGTTHILGPEEVVNKIYEKIPNSRPSASHRQYMEYPCNQTVDDVKITFGDFELQMTNADFNAGEVKERPGWCLGTFYIGRLSSNNPVNWIFGASALKNAYTVFDNQNQQVGFAKLADGLNTPADSTGTASGGQQLLPSDLPAAQPLDEAPIPDEDPNAAHDVVTDEQASAAPSPDPSSSASPSPSSSASSSASASPSASPSGSSASPSSVGTSDSSSPSAKPSSTESKPAGASSAAAPSASPSEKSAARGLLPSLTALAAAGLAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLA3</accession>
    <name>K1VLA3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLA3"/>
    <dbReference type="STRING" id="1220162.K1VLA3"/>
    <dbReference type="HOGENOM" id="CLU_2110663_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLA3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="115" mass="12952" checksum="C3C43BE925119826" modified="2012-11-28" version="1">MNITPEPVSWFDLVVACGLDDVRAVSLHQLLQRLPTPPPHLPSVQDVSEALVPRFQSTFQRQFLPLSADATRDGEGADLEFMRRIVQDTERKAEEYVKEQGGWPTKPDTSRPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMH8</accession>
    <name>K1VMH8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000092">
        <property type="protein sequence ID" value="EKD05395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMH8"/>
    <dbReference type="HOGENOM" id="CLU_1112005_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMH8"/>
    <dbReference type="OMA" id="WMSIEDC"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854242" evidence="2">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="264" mass="27117" checksum="C29AA63E4B6371D7" modified="2012-11-28" version="1">MTVLLLSALLATPALAQTPSGANPALVSCTSELSRSLCWGGELTPDFDACPDTWTCVGVNCCPPWMSIEDCSKFNGIGPHQGDDWDDADDSDKKNGNNNDGDDDDDDDDDDDRKSSAPSPSTVLSEVLPGVFNRPSGTANVTVVPSATAKAGDDDDDHDDHNDDNDNNDDGNDDNDVDDDDGNDSDDDDDDKATPQVTASPSASASVKETPAIALSPSPSAAARSSAAAAPGSAGANADSGATCQRRISLTLATLLLGAAGWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMS3</accession>
    <name>K1VMS3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000336">
        <property type="protein sequence ID" value="EKD00652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMS3"/>
    <dbReference type="FunCoup" id="K1VMS3">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMS3"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_1_1"/>
    <dbReference type="InParanoid" id="K1VMS3"/>
    <dbReference type="OMA" id="EFGFNFK"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854250" description="Dipeptidyl-peptidase V" evidence="7">
        <location>
            <begin position="18"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="540"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="774" mass="85913" checksum="0DFD7142B9277E06" modified="2012-11-28" version="1">MLSKLAPLGMLALGVMASKEFTPVDMLSTPRPQAPVVAPNGGSAISVVDQWEEKSNTGETGAGCSCLSLGALDGPSGGSSVSLTVRMSRTVYLTETKEKAKPRKLFAATPGSASELIWLSDTTVAYLNGTTMHHFSIKHDPIRTMHLLDLPKGTEPSALTYEPESHLLVFSAAVWGADSSLEETAKGDKKWDNRGTSAYVYDDLFVRHWDTWRIPGRVYTLAATELHRKKKDEEEVFEASSRFTNLLAGTGLYSQVDAISKDQFSVSPKEIALAIKPTDIDPALHTRLDVYLLPHKGGKATQLTSTDHGAVSGVRFSPGGKKLAWLQMAQDGYESDRRVVMVYTPGLVGGSIEAWTQKWDRSPSYVNWDLDGDSLYVLAEHHGKDVPYHLDAPGALPTPLHFHGSTSSITQVRKDLFLLSISSFTSPTELFLLDLEDEAYLHSVAQAVEDHDHGRPGRGHGDPDKRPPEALHQLTHFAEKHIGGRLDKIDIDALWFRGDEDWRVMAWVLKPPGYSEDDSAKWPLAFLIHGGPQGAWTESWSTRWNPAVYAAAGYVVVAVNPTGSTGYGQEFTDRIARHWGSRPFRDLLLGYRAALEHYPGIDKERTAALGASYGGYMVNWIQGHNEFGFKALVYHDGMLSTTTSYYETEELWFPTHDFGGTPTSDRDAYEEYNPMNYVQNWHTPQLVLQGGMDFRLPVTQALGTFTALQVRGVPSRLVYFPDENHWVLKAANSRKWHHEVFAWLDKYVGKGKNGPKNDSAPEEAQEEPQFVIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMV4</accession>
    <name>K1VMV4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMV4"/>
    <dbReference type="STRING" id="1220162.K1VMV4"/>
    <dbReference type="eggNOG" id="ENOG502TKUB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379556_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMV4"/>
    <dbReference type="OrthoDB" id="2596481at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="730" mass="78587" checksum="7FA0F9B866A35057" modified="2012-11-28" version="1">MVVRADPSCPFEFSATLASSPCNPPSPALHSPGLFSRNLVLERQRAAARPPVRLRSHLRVLLPCTRRRTRVYATIPSLDVNMRSRSTTPSSSDVSADFSVVSPPTDPVNPLATAMEQVNLDNSPPSASDEDSFEIVVMPVSPASEQSESSLFSVLSIPTSVDSDRGRDSSSDSASDDLLSDSASGRSQGSAPVSSERPAAEDAPPKESTHLHTTRSIPASPSVDVASLPTPPSLLQPPKSYQVGSTAPYSTAMTLSGRGADTAADPMSGLTMNQRKSRRKAAAKAAAHLVLLGKQPPDEATAGFTDAQRVQFNRILQEVTTAANDWALKLCSIISPAEQSTLSKKKLKARRKAAVDAAVKAVQAGQRTSVHATIGFTEAQNRAFDQAVSKQQGKNRRQAEVQAAVKAVTAGWQTQNEATCRLTADQKTNFKQALEAQAKHNRAVVDPSLLSKQQRRRRRDAAVKAATRAVLVGEMNPEEAAIGFNHFQMLQLRDHLLQATKPASTWSSIMARGGTLSVNQCTKLTHARRRNADPTGSDDDRTESESGYSTDTSSTMSSQDAASAIYADTDSFTSQQENKLRLWQALCIEFGLVEAGDLADLPSQRTHRSSAPSPPSQRPPPSTFSDSDESTTPSRSVTPTQANPFPTSLTQAKNLLSTAHVNLSTYMALRKSNPNPEPGEYADLLEPSASALRKLLRESRQFAKLSDVKAEWLNPLLKDFGFARSRARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMZ2</accession>
    <name>K1VMZ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMZ2"/>
    <dbReference type="HOGENOM" id="CLU_1511654_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMZ2"/>
    <dbReference type="OrthoDB" id="2562728at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="178" mass="19803" checksum="D18C0AA2B3F0C3C2" modified="2012-11-28" version="1">MPSNVTWSAAHDPPCPSSTTPRPPIDHPLTSCVPEPLADPQTALLTSLVSLILSNRREVYRAPGLSDVANNGGSRINQRLLLMLRKMCTDFGERGLVDELVRAQQAQKPGGGRKRKSDTAEEDERKVKIEKVEKQKGGKEEKDEKGGVGGMGEREKTKKEMRDEILRGDHEIMPKFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN30</accession>
    <name>K1VN30_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN30"/>
    <dbReference type="eggNOG" id="ENOG502RBGG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445633_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN30"/>
    <dbReference type="OMA" id="CHEERYQ"/>
    <dbReference type="OrthoDB" id="2573557at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="613" mass="66968" checksum="4B9E62B2D79A891E" modified="2012-11-28" version="1">MKMDVTLSIPSAFRTRQRPKTAQAKAQTSSTAASGSGPSRPRQSGRGLAGGLGAGLSALGGGPGGPSAILPVPTNVRNSSTSTLPVYPSNPRPPSSTPALPTTSDFPTPDSDSVKVTIIRRSNTQKGVRFQDPSSSTPALTQYTDPVEPVDPPSYLETPDSTPTAPLANRRHSTTFIEESSRRISATPPALAIKQLRLAFQDTPPMLRTLEDGWRARRSRTLDVSTTSVDKPLKSTKSLLRRAKTPESKVDPYLLEQAELARRRMPEPAHRSASGTHIAPQSKADQSANHLGRHSMIVDSNAMTRPPHLPLTPPTSPPPLPTISTVTADGPAHYTQAQVHQPQAPSYPPPHVPETINTQGTTDTAPPSPTSITAQLKPISTSCLPPTKHAVPLHKKSAAKITVHNISHPVSLTLGFQGTTVRVNKAGDEIAISSGPEKQRTRTILRLADSEDWGEEECQYWLRLLSLVDEYKRRTPKLKVFTEMGDLTISCSDQPDVILVYSIESNHLQLDNLEIVPNSMTKVRIRYSNPKEFEIETSSKTKDGGRLKTRRIGPLTKNSATHTEGDFELFWQATLLGIVIGQDWNEVEKEAVKRLYALRKEWVRSVRIEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN34</accession>
    <name>K1VN34_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN34"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565231_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN34"/>
    <dbReference type="OMA" id="SVEYWHA"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="483" mass="53306" checksum="E63C9AB13E05F2F3" modified="2012-11-28" version="1">MSRHDEREAEAYELTDVEDLDEFEQRHKPRQRTSVDSDENDENIALLASDGEVRRDEVVGKGSKVEQLIDSVSFHGTLQLNPGILYNVLVARPAMYWPSTLVIVQLFTTLFDETASASSSAARRLTSKRLQVFVLIFLATFIYQSWVMRWLGSAYTGLGMMDFSFDWASVGAVGPLFTPYWALGNYFGGLIGMMWIIVPILLVFNFWNARDFPSPTSAGLFNTAYAKFDVPAVLSPDLSLDDAKWETAQPILLTPYFAITYGLAFAAQTHEGVSRGAALVVLHHAGRESRRGHLDGVDDAAAADAGLGAAAGADHCCCVIIDYLEPNSRIGIVAAVSNTTIGLLTKDMAMFQSLQLVSDLKLGWYTSIPPREMFAAQILGTVLGALTNSDRPDVTLQSVLSSKRSYLDGTEVDPTGQWTGRRPQIFYSASIIWGAVGPARFFAGKYRVLYLGFPLGALVPVVLWWAHRRWPGYKLHKVSLIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNB9</accession>
    <name>K1VNB9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000005">
        <property type="protein sequence ID" value="EKD05690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNB9"/>
    <dbReference type="HOGENOM" id="CLU_2456350_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNB9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852283" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="89" mass="9312" checksum="A45429566599E680" modified="2012-11-28" version="1">MKFSTTALIAAFAATAAAETCFPSWICDSIGAEGFSCDSDDCRSFRASVRDQLYAGAGIMFSNGDDASRAVAERKLAAANAVNNYINGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNG5</accession>
    <name>K1VNG5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNG5"/>
    <dbReference type="HOGENOM" id="CLU_1603912_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNG5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="166" mass="17581" checksum="97C68195B1B754A3" modified="2012-11-28" version="1">MAQCDRPPAPASHSTLSSMASDLASLPAATSTSVRGQSGAVMRRGWLTNPSIAMPSSKHHSPCTPLPTAHVESQTAPPAPPLHAADSGVAIRDGVVDRDNFGANHPSARALPQSRNPPTARTPRAQRAFLATHAQCSRCNERMERMVEATGAINQSQISYIQEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNH0</accession>
    <name>K1VNH0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNH0"/>
    <dbReference type="STRING" id="1220162.K1VNH0"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="K1VNH0"/>
    <dbReference type="OMA" id="RIKARYK"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="443"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="641" mass="71050" checksum="8B491B51DC37E920" modified="2012-11-28" version="1">MTNPAGKESKVDVLIVGAGPAGLMLATQLAQLNIDCRVVDKMAHPVLRGHADGLQCRTEEVFDALGLKAAFDAETHECAEVVIWDPTEDGGIVESNRVVDTTPGLSRCKHVNLGQDRVEAIFLADMEKNGLKVDRLLTPTSMVIDEERLDDPSAYPVTVTLKKLPKPKEEANGDVQSGLYRSNLFVDESSTAGNDTEAEADETVHCKYFVGCDGARSWVRKALGLELKGDSANVYWGAFDAVIDTDLPTSRMKHVVHSKNDGTVLMVPREDSMVRIYTQMGTLAPGERVDRAAVTLERLCAKTQDVVRPYKIDFPYVDWYTCYEIGQRVCDTFAMHGDHVLIAGDACHTHSPKAGQGMNVSMMDTFNLGWKLASVLRGQAKMGLIHTYHEERRKTAKELIDFDRKFSAMFTGQAKPEELDLFSPEQMRGAWEQSIRFTSGTGVQYLPNDIVLDGSKGRQSQLAKKITPGQHLENQQVFGAFNAHAIQLQAAVKADGRWRIIVFPGDVRNADRLQAYNALGEDLEQLSKTYTPKDADPDAVIQTLTVFDSPHKDVQYLAGKLPSVYLPRRKPWNIRAFDTAFTDEDTYHDGPCAAYKGYGIDPNVGAVIVVRPDQYVSGVFPMDGGKDIAAFFDRFMIQQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNQ3</accession>
    <name>K1VNQ3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNQ3"/>
    <dbReference type="FunCoup" id="K1VNQ3">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNQ3"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_0_1"/>
    <dbReference type="InParanoid" id="K1VNQ3"/>
    <dbReference type="OMA" id="QESMKQP"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="384"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="504"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="698" mass="75902" checksum="5A9AEC79AFD99A69" modified="2012-11-28" version="1">MASPRNISKSPRPSDDSEQALSSSVARAQASGSLTVGTPPLPQIPRREISNSFQARTVAERSSAKGEEPASSGSSLSGLGNKAALPAQPTSSNLTASLTLDKDHNHNKDPVDRTGTPDLDGTLTPQPDESAFSAVAGVPDEEKAKVLRRHLVSAEERTSNAPTPSAKLSPAASPGPSSRNEDPGESAITRRSDGDDDPFPIPYDAPGGDVTHEVYKWQQDHQRTRRSSRAQSFSHADRSAIIDPQLAQMKEPGGFRRNFVVARAQERGVEEPPMIRNFVDFLFLYGHFAGEDLDEDEDIDDEDDHAIAEEGRGVSRVAGSSRDATERTPLLRSRSSTRRPTRPGQGTASLTQAVLMASSAPAFCSWARPSTMEVLPDGWTLTPDIGGALYGKYMRDTILFSITVSQIGFVAAYTIFIAENLQALLLSVSDCKWNVPIGTLIFGQLLLFLPLAMIRNLAKLSGTALVADAFILVGRCCRRYAVQSRQLPAADWHFGLCVRGHRTEPQKFPRALSAVMFVVAVLFAGFGVLGYAAYGSDVQTVVLTNLPQDQKFVQVSQFLYSIAILLSIPLQLFPAVRIMETGLFSRSGKHNPRVKWQKNIFRAGTVLFCSMLSWAGSSELDKFVSLIGSFACIPLCFIYPPMLHLKACARTRTEKALDYLLIAFGVIVGLYTTVQTIRSLFDSSSSELPRSGKCDNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNT5</accession>
    <name>K1VNT5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNT5"/>
    <dbReference type="HOGENOM" id="CLU_2456354_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNT5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="89" mass="9799" checksum="4EC7289D570E52EF" modified="2012-11-28" version="1">MLSLRAAVRVPRAVASLHTTAVAARPQTRPPSDGSGPLFTTPFEIQMGYRDADKEAKDAKKQTGTDKMNKMKGGKSFQDLRKQHDEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPN8</accession>
    <name>K1VPN8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPN8"/>
    <dbReference type="STRING" id="1220162.K1VPN8"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_1_1_1"/>
    <dbReference type="InParanoid" id="K1VPN8"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="398" mass="43677" checksum="676DBD078FEA01CF" modified="2012-11-28" version="1">MAPTMAPTTAPTRVPTQAPGRVPPVTATPTRAPGVPPSNAPTTNGDIGEVLAALPTDPAPPQPVLTSERNVAAWPSTPGYQSFQVWLKQRCARIQGQPIRRGKEGVKAELMDMLDALMSWIEEVPPQPQSSQRFGNLAFRTYISLVEQRLPPMLDWMDERLRGQVLPLLIQSHAFGHKTRLDYGTGHELAFACALYCITLSLAMSNDPETDAIADDLVLRVFPRYLDLTTQLQATYRLEPAGSHGVWGLDDYVFLPYYFGSAQVLGSDLTPAQALKDATRPGTKPEDFEDMYTLALHRVGYFKKGARFSEHSPLLYSLSQFPNWVKVHAGLGKMFAAEVLGKRVVVQGLWVGGWLWGNPLPHVEREEADKPKSPFTAAPSAASPFPATSAPGRTTRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPU5</accession>
    <name>K1VPU5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPU5"/>
    <dbReference type="FunCoup" id="K1VPU5">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPU5"/>
    <dbReference type="eggNOG" id="ENOG502S81F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPU5"/>
    <dbReference type="OMA" id="KYTVFDR"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="105" mass="12205" checksum="8821DECF0B37C6A9" modified="2012-11-28" version="1">MFGAFRPTSFVNGSLLWKVPYRLSSTRKANLRKRLRRVDDVIAAVAESGVQTRSLERAQALPTEAEMKPKDKYTVFDPKYRGWRKGIHKVPKWTRITIRENPKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQQ7</accession>
    <name>K1VQQ7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQQ7"/>
    <dbReference type="FunCoup" id="K1VQQ7">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQQ7"/>
    <dbReference type="eggNOG" id="ENOG502S9YH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079421_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQQ7"/>
    <dbReference type="OMA" id="YLYNQYT"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27113" checksum="57DEBE7FE93F5BCA" modified="2012-11-28" version="1">MPPRPAVNILRRAASTLAEKPALASTQPGRVYPERKAFLFKYYEHLLQRSQLVLLFKHQNLSVAQSQQIRHAIQKIPVPALPAATAAEAAEGSPAPEAERAVMTITRTGLLAPVVRSVQIGGAGLESHLQGPTALITCPTISPKYVKQVLAAIETTIKKNSKKAEKKDEVVKNPEFTLVAGVLEGSRLMDPKQIKDVAQLPELDQLRAQLLGLLEMPGRQLLGVLNQAGGGGLVRTLQGLEESLKKDAAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRB2</accession>
    <name>K1VRB2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_03717</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRB2"/>
    <dbReference type="FunCoup" id="K1VRB2">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRB2"/>
    <dbReference type="eggNOG" id="KOG1360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_6_0_1"/>
    <dbReference type="InParanoid" id="K1VRB2"/>
    <dbReference type="OMA" id="WRASEYV"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="299"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD02017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="746" mass="80330" checksum="CEB379FAC1916B3E" modified="2012-11-28" version="1">MEELGVQDVGCPDLLTVLLIAHQKTEEVYSSRRRHGGHGLRRLRKVRWRASEYVETAPNWPIWAGDPARVSQPQAAYNISHPANHPPPSPHSSGLSLLLKTAPGSWIVSLNLENTTDSKHKAIMKVTSLLRYSRACPFLGHSTPSSLRTLASTGSSTGANALTAKAIECPMMGPRLASKSQARAYASVAGNREVEEIHKQKDINFDPTGTPAGKCPHAKAAQQAASVAQQAVNAKAAGKGKAPVARNTAGGFDYETFYQAELDKKHKDKSYRYFNNINRMAAKFPVAHTAKTSEEVDVWCSNDYLGMSKNPIVLDTMRRSLNKYGAGAGGTRNIAGNGALHLALEDELAGLHRKQGALVFSSCYVANDATLSTLGSKLPGCVIFSDQMNHASMIQGIRHSTAKKVIFKHNDLADLEAKLQAVPKDTPKIIAFESVYSMSGSVAPIEAMCDLAEKYGAITFLDEVHAVGMYGPTGAGVAEHLDFTAHYATRDSAEPVPRSVMDRIDIITGTLGKAYGVVGGYIAGSADLVDLVRSYAPGFIFTTSLPPSVVAGAQASIAYQREYMGDRRLQQLNTRNVKSQLKGLDIPVVPNPSHIVPVLVGDAALAKEASDMLLAKHHIYVQSINYPTVPVGDERLRITPTPGHTAEQVEHLITSLDSVFNELDLKRESDWVAVGGRAGVGCPNTKVPEPVWNDAQLGLEDGSAPVTLAQGKEHVLLPEAIKVAEKRLTHLLDVGPRLSHEASESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSI3</accession>
    <name>K1VSI3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSI3"/>
    <dbReference type="STRING" id="1220162.K1VSI3"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339536_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSI3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="837" mass="92519" checksum="82BC4148FED9B788" modified="2012-11-28" version="1">MRTARTLRPLFRTRLTSVTRPGVATSVAPLGTRGRWSIANPVTNLIGSVREDASILPTYTVVHPVNGKVHAVQHSTAVDIEQALACAHGALASWSATPLEERKKIFERAADLLESPEWSEKLHTMNRAETSVPEWWSREQLKIAPQMIRALVGYADEALAEKTEKMGDTTFHVTREPYGVCLAIAAWNAVHLLTLRAIVTPLLTGNTVVLKTSEVTPGSQALWAELLYEAGVPKTALSVVHAAPDEAPGLTEQLVRDNRVRHVNFTGSTRVGRIVASLAGAGLKPCIMELGGKAPVLLLPDADIETAASHILFGAFFNQGQVCMSTERVLVPESRFGELVTALQKAWREVEDKSPKAPFRPDAVARLGELVDDAVSKGAQMLIPVAEAGEGTFPHTILGPVTQDMRLWTEETFGPLAVVIPVPDDGAVDTMVDIANESEYGLSAAVWGQDLQNAEKVARRLHSGAVHINSPILVRHLPHQLYSDIPRIAPLNILVIFLPIHPTDDTYADASPKFQSSPQPHNPSEKDSMPEEKAPKTRPMDRVHVLDFEPLHMGYPMASMKSVLLVDFEVQVHGLEEMSKKKKPVSIIIIAHGWANKAEQHWRMASGMLGEISRFERESGVERANDVLVVTLDQRNHGTRRRIKDGRTFQNDPLRLAHMACTITGGKQDQELVMQFLPPYLWPDGEREVAHWLPCGISLGGHTTWRLLRENPKITCGVPIVSLPSETLGSWLANRAETGLKHGTVTKETKYPPSLAAYWDGPTPPNAYKGKKILCIYGGEDAVLPWKVGQEKWEWIKTMQEHPGEMDQWIEPGFGHVITVGMVSKTAEWFWRWAVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSJ0</accession>
    <name>K1VSJ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSJ0"/>
    <dbReference type="FunCoup" id="K1VSJ0">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSJ0"/>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012678_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSJ0"/>
    <dbReference type="OMA" id="STEFYDI"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="59335" checksum="DE8C3690706C9CB5" modified="2012-11-28" version="1">MNELAQLTYKQGDFVEIMEMLDKRLNDKGKNWRHVFKALTVLDYILHAGSENVVIYFKDNLYIVKTLKEFVYVDDQGKDVGHNVRQKAKDITNLLQDEDRLRAERRQRGAMRDRMLGNIADHGLQGEDDYGGRNYDSSWRDQERQERRPTRRNDDEDSDLQRALAESMQSSQDEDRRRSQQRKEEDELQRAIRLSEEEEAKRKREQEEANQRALMDDSFQLESNNMYTQQPQQTGFPLVDMSGGWNQQQLQPQYTSFNVSLSFLYLETNVQPFAAQMQQQQQQQQMYQQQLLQQQQQEEYMRQQQEAQARAQMQSSLLPQHTAYGSNNPFAPKPTMPQQTGSLFDSNPQPQIQQQPTGMFGNSFNPQDNNNNAFTPQSNQTLTPTPAAPKPFAAPKKDDGEHAGLANLIGRGREDGLDTFGNVGNLREYCTALSGVTADIALARSAECQKAKTADDAGASTQTRKAMQSAAALPAITRKIFADVQGTGLGANNPFGQQNNNNQQNQQQQQTNNEQPFFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSW1</accession>
    <name>K1VSW1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSW1"/>
    <dbReference type="FunCoup" id="K1VSW1">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSW1"/>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_4_3_1"/>
    <dbReference type="InParanoid" id="K1VSW1"/>
    <dbReference type="OMA" id="NAAMIGC"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="66"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="409" mass="44050" checksum="6605FCF7BFE41E91" modified="2012-11-28" version="1">MLLRPPVVVRFFGAAASSARAGPSRSYRSAHLFHATSTTRKPLTILALESSADDSCCAIVDSERKIHANVVLKQHHINATQGGINPIRAQEAHERNVPLAIRQALKTANMTIGDIDAVAYTRGPGMYGCLCISASAARGIAAANDKPLVGVHHMQAHALTPLLTEEKPPEFPFLVLLVSGGHTQLYWVSLADLFFQQANGSDATDKIGRALQLPDGDRGLGAALEAMAAKPPLPPFDTQPVPPMPLPMQRQKGTLAFSFAGVLSAVERKIAELGDPAVYDEARARELSRVWQELAFGHLGNMIGRYLDSDVAKADGDPVKGLVISGGVGSNLQLRKTLADLLAPRGIEVAYPPVALCTDNAAMIAWTAILRLQNGLRGEEPTLDIRRKWSLEDLYDDVPPEAYETVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT00</accession>
    <name>K1VT00_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Karyogamy-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT00"/>
    <dbReference type="FunCoup" id="K1VT00">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT00"/>
    <dbReference type="eggNOG" id="KOG1128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004905_0_1_1"/>
    <dbReference type="InParanoid" id="K1VT00"/>
    <dbReference type="OMA" id="NNRYARA"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="877" mass="97904" checksum="F3982E9B52AF7EA1" modified="2012-11-28" version="1">MSTTEWALATSKAPEGSDRPAELVGQVVKADFQPVLESDDVKAALKRVPKLLDGLQDTMDVDSAGEEDYATLLAAAVALQHAFVQANWTGPDLKFTPADVVAWITGTDSSDKDAANTKLNSAALPYLTLLGEPAYHLAAHPALFLLSVRILKYLADKKATLVTLPWWRLRSHLVHLALLDEAVPLDDEIVGDVGALIPSAPDADTAAMLSLELGLLHYKLGQDKPANNAFLTAARASGLEFELTGAMGKRTKFQTQDHSQLLLLAESRKRDGEDGKVVPSKGAPEALKLNDDTLLEQTEYTSTTGGSGALSHLDPGNQPALHPLDQALLLSLCLNQANSSPSHGLTIQQMMPFVQRVVTHPTNWSVHTTALILRARLESHRSRTVERSALQLAALIDQMPTSDSEPTERLQYFHQLPLPSKWEMEKELAKRYLSLGVIRSALDIFTRLEMWEDAVACLQHMEREAEAERIVRDLLEGRKLESDVVQAMGRASLSDARREKLGWAREAKLWCLLGDLALNSDDAPKNPTKARETAIEYYNKAWEVSRHSSSRAQRSLGTLYTSAQDFEAAVPAFRHALAINPLYAHAWFTLGVCLMRLGRWAEARDAFKRQVGVAEDDSEGWNNLAAVYLRMNEEGVPEGEKPPPVSFENKQLAYHALRSGLRSSYNNWRMWANYMVVAIDVGELNEAARAQARVVEEMFDKDPVVAVDPDVLDKLVDSVTRDEWNGGEPAQPPTTSNEGWGLYPVVDRLFEKTILPRISDNPRVWRAHARLLRWKEDWAGAIDDYIRAYRAEVADDERVERDVKRWREAVNSIEDLVATLEQLGPRVPKVEGKKGGDWRFQARGIVRTFMGRTRNAFENEPEWDRLKDLLDELKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT33</accession>
    <name>K1VT33_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclin dependent kinase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT33"/>
    <dbReference type="STRING" id="1220162.K1VT33"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305697_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT33"/>
    <dbReference type="OMA" id="MFQGNTE"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="465"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="791"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="896"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="993" mass="110334" checksum="262B8E1D8AE49F38" modified="2012-11-28" version="1">MFPPPGTNGLPPKPGTHSSPVKNDLASRLSSAPGAGQNAAGGLNIRGHADKAPRPAESSSAPREELHIRSSASRDQAPRDAHPPDHHRQPREPPRDSRDREPRDARDQRGEPHRRDHDRRDPPPRPLDPARDRDRNGHRSPRAYDRRDDRRDDRRDDRRDDREREHRRASPSKERHPADRYDSYGGDRGRYDRYPPRDRYDDRYDDHRRDPRDYRDSRDDRRGGYRDDRRYDRRDDHRRHDHRRSSPSKREDGEVHEDGEILEPAVKADKPSSPTGEAKRRRSRSPVKHAHLPPRPATPPLPPPRHGTSKEASHSHRPPTPPPKESASHTRPPTPPTKDKNGRPPTPPLTEGAGARPAEPNTSPPPPPPDDLPPPPPPPPGAPPPPPSDTPSGTPDAPPPTKKAYAPRPHAPNRNLNESTSTPRALTPQPSREPPSLKHFKMRSTEEEQDVYARKFRGVTTLASYDIGLKLGEGTFGVVTKATDRTTGRKVALKKLITHNPRDGVSVTTVREIKILKELRHPNVVPILDMVVQRKKDKTQLMPGEPMCRGEVFMVFPYMDHDLCGLLLNKDFRMTHSVAKLLLRQILQGLAYMHGNNIIHRDLKTANILVGKDGSVMIADFGLARTLGTEPLPKHSKHEYTNMVVTRWYRAPELLLGDVHYGPAIDLWSMGCILGEMYLREPIFPGDSDRDQLLKIFARVEPPNQRVWPGWDKLPGFPDAKNHPWDKTHKETNLLSLARKWQMDRAGADLMVKLLTLDPSKRPTANDALDHVWFWSEPLPAKLGNIPVVESSHEMTTRERAPANRGRPQNPAWVQPPPQAHARPQHGRHGYQGQHPRPQYMHQQQQPQHRPPPGYMPPAVPAMAMGHAGPGFNNNMGGPHGPNHGGNHPNSYGRGPAMGGQGHGPPGGHQGGGRGPPPPFKLAGSGGAGGAGAGLPPNPNTGRVPAPAFRLAGGRQPGGAPSFGGAGGPHKRQSQGEPRGRDKRPRTDGSLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTA9</accession>
    <name>K1VTA9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTA9"/>
    <dbReference type="FunCoup" id="K1VTA9">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTA9"/>
    <dbReference type="eggNOG" id="ENOG502RYIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_5_1"/>
    <dbReference type="InParanoid" id="K1VTA9"/>
    <dbReference type="OMA" id="TQIWKLC"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="9">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="8">
        <location>
            <begin position="162"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="278" mass="30152" checksum="9EB39734539DCE20" modified="2012-11-28" version="1">MATSMSDSDVVIVELGGKKVLLVGGGEIASQRLGFLLEAGAHVTIVAPAPLHPLIQHRLESNGDQITWHDRQYNQNPDKDACKVGSYDMVFTAIDDAVLSRLICEKSRKARTPVNVADVPPECDFYFGAQVRRGPLQVMISTSGAGPKVSVMVRDLIRGVIPNNIEGVINGVGALRRELRERAPGVGGELSKKRMRWMINTCNQWDMEVMDRLEDETIREKLLTDGWEKGVVLGPKDVGVKRKSKSRAPSSTALAGTGGVLVGAAIGVLATLAYLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTC6</accession>
    <name>K1VTC6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTC6"/>
    <dbReference type="STRING" id="1220162.K1VTC6"/>
    <dbReference type="eggNOG" id="ENOG502S7I9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056801_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTC6"/>
    <dbReference type="OMA" id="YITWLAK"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="158"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="414" mass="45505" checksum="21ABCF7A5A4E17B1" modified="2012-11-28" version="1">MSTALDWPKLRRSSPDPTAPRTPPAPLLALYKLLAALGVLGSLPFVIPYTILTHFLRGPRLRWQTLRDHLITNIVRVALIQHTLFLPGVDWFEWRAVRSKSSDAPGVTVTKVTLPPAKLPRTGFAVCPAVPAVPRPGFVVTPKSKQALAKAAPGEKAMLYFVGGGYAFGHPLERTYVFKVAHDINIRVLAVNYRKTLTPETAFPAPLLDAVAGWEYLTNALGFEPKNITVMGESAGANLSLLLQRYLYDSGVEGPGQLALSGPWVDMSPTNITRASMVNNWGVDYITWLAKLSAHAARQHYTDEAATTPYFAPANATGAQWSNLVKPGVKVYIHGGEKEILVDEIRTLYKNMSEAGVDVVYVEEPHGFHITPTMSDIFQGSTGYKVFSKDIYPLIHREVDPTNWPPSQGDKKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTI1</accession>
    <name>K1VTI1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01889</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTI1"/>
    <dbReference type="STRING" id="1220162.K1VTI1"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="K1VTI1"/>
    <dbReference type="OMA" id="RIIVYIS"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="18"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="547" mass="60888" checksum="26BAD08BAC94DAA4" modified="2012-11-28" version="1">MGRVRTAWKAWTPMLVFSCFCLVVGDMLFGFDTGSFGGILAMPGLSHFVRLHRKMTNPQGFLNQFGTETNGKWALTPLRTSLLSSLAFIGKAIGCLGAGPLIEWLGHRKVFVILCIISCIGVIIEITSADTALGSGRLAQFIVGRIIVYISVGLVEICISTYQAEIVPAPLRGFTVCSLQLFLNAGGLLATGVNKAFSKDDTSRGWKTVTGIQFVFPVLIMAFVPFLPDSPRWLLSKDRPADALHSMRRLRTREEVASGACAEELAVIQVQLQQRVHKASWLDCFRGTNARRTGLVIAYYIYQQITGQAWVSTYQTVFYKENGYADHAFTYPIISSCLSVLAVLPCMYFSDVLGRRKVLLGSFFFQALWLCLLAGIGERSNKTESMKEACVAFFMLFAVSYSLGGAPVPYLLGAELPNHSLREKTSTIGTTINVVFAFATNFSIPYMMKALHFRVGWIFGGISISALVFTFLFLPETKNLTLEQVDHLFEKPYNPFRSFAKLDRWTKHPALLEQGLQEPDPAYIDSWPSSTDSDKDKDIMRYESDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUE8</accession>
    <name>K1VUE8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUE8"/>
    <dbReference type="HOGENOM" id="CLU_834670_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUE8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="333" mass="34514" checksum="E185175F4FC86891" modified="2012-11-28" version="1">MDDKMEVREWPWPEDVDGIAGGEGEEVAPPVRNDFPGAEYQAEAVGVPVIVPELPPSPALGGTEEVAHILQSTDPYAPNYVPPAGTSAGPVEHVTKQAAATASGTASGSPSAQMDTPTGPAVPSVRTTTTIAPTPTVLPPMASDGSSLSPPNKPVGTRTVEFITVTATPTVLPSAISAASSSSSTPVGAIVGGVLGALALLILLGAGFLFFRRRRRRYAPLKPLPREARPLVQPFEPLSPVSGAGTGVRKSMTDTVLVPTERSAGFAGAPRARDSMDINQLNQANLLEIAEREQRAEMLGAELETPGAGPSRTTGSGSSERRYDPPAYASWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVA5</accession>
    <name>K1VVA5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_04885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVA5"/>
    <dbReference type="FunCoup" id="K1VVA5">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVA5"/>
    <dbReference type="eggNOG" id="KOG2094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_11_2_1"/>
    <dbReference type="InParanoid" id="K1VVA5"/>
    <dbReference type="OMA" id="TADWHEP"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="227"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="512"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD00693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="618" mass="67507" checksum="72D567CFCF273A93" modified="2012-11-28" version="1">MTDLRELGVADTEDLGDHGGVGVTETSSTAPVDLGLAASGPSRLSFSPPPLPLDEEDELPPGAPSSDPWTADDLAAIAAAEAAERQRLSFERSLAGPSVGKADGYADHVSCKLTLEINRIIAEASKGSKFYENQVRKDKELTEKIAWFCAKRDELLRETPREKILADADRILMEVEADRDLSQTIVHVDVDAFYAAVECKRDPSLKGKAFGVGQGVLTTASLTGSTPLHFDLYTEASRKIREVLLKVSYTILHRADIQYDANLMMAGLDEGITGYIQQHDVTALEAVEKLRAEVEAATGLTISAGIAPNRMLAKPNGVFELEFNRATIVKFMHDLPVRKIPGFGRVTERCLEGFGVELTGSKAHLGIADNSVQPYKREERKSVGVERTFRDKWEDEDILAELANIAEELEDDLKRLQYSGKTVTVKYKLHTYESKSRAQSVKKYINTKDDILPELPVRIRLLGIRLSNLKDLTVPETGIKEFFAKSASSSPKKTKPATKSPELDLSQIDEAVEASSSAPETSAPGVPGEALDTDPSPSNPGPLCPICQRALGPETTNAQLNEHIDLCLNRGVEGIETSPVKRKEPTSTQGTQGTQATQGRRKKKRKEGPTVLDWLKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVN3</accession>
    <name>K1VVN3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000220">
        <property type="protein sequence ID" value="EKD04601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVN3"/>
    <dbReference type="HOGENOM" id="CLU_906698_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVN3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="307" mass="32319" checksum="B7F904C80BFDC2B3" modified="2012-11-28" version="1">MGGGTGVAYFSHLSSCLYSSQALGLVLCIGFPGTSPRVDRHDRSSGYPGIAPGFEWSSHRAEDEREDEGQLAIALALACGSGSGSASARALVIPNPSPTHHAHATPLHPLAHAARVPDMSTVGETEHTVPAPKLGHAHGTAANPGSQHAHLQLHLACGIDAAAVDAHRALDEGLEGLSRRARVYRRAEERLDVCEALELAPTPLQSRDVDVHIGQVRVALSVLLAGDGSGGAGGEVGRRGRGLRHLERGLGGQRGGRLRVSRRQGGRGRRRVETFDRGRRRRARDGARPALGGTEEIVPRAAEDVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWU5</accession>
    <name>K1VWU5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000168">
        <property type="protein sequence ID" value="EKD04991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWU5"/>
    <dbReference type="STRING" id="1220162.K1VWU5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347544_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWU5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF36">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="812" mass="88788" checksum="0846D56AB5094590" modified="2012-11-28" version="1">MAGIEEKTYVHHDDKASIHLAEIGKVQRTSDNNKHLSPELAAALETCAIRPWSSSSIHLYVSILCALCCAYANGYDGSLMTAINAMPFWQERFGHIGTTGTMVSVVFSMYNVGCFIGGFPAAWITDRFGRRAGMAAGAGIIIVGSILLSTSHHIGQFIVGRLILGFGIASAQLAAPAYVVEVAPPHWKGRCVGIYNCGWYAGAIPAAAITFGCNYINSDASWIIPIVLQCAACIGVLGLVPFIPESPRYLMQQGKEEQALSILAKFHGGGDPNNALVQLEMEEMRSAVALDAANNTEAWWDYRPLFATKSNAWRMFSGNGLAYFATVIFEQIGVTSVTAQLGYNLMYSALAVVGALTGAILTDRMKRRYVLSFGTGVLSITLAVFVALTSVIQKAVDKDEPINAAVGKGAIAVYILFGVFCAFVYTPLQATVTVEHLSTSMRAKGLALCNVASQAMGFINLFAGPIALANIGYYYVMFFIFWDLVEALCWWFFGVEAQGRSLEELDWVYEQPNPIAASKKLREGLPLHHTDSPLGMSLASKRVAKKLPGGSPVSSRKPRRPPNPWILYRAAKYEVLKDGKVIPSLELALIQTGLWRPESIRGSNETRDQDNGHDICNISPANALPQSSLTKVFSLLWRWERPEVRKRYSYLSQLKKQEYPDYKYKPVRRNNEVPTSLGDKQRKQVKRESLDPKLGHELTEVKAAAWALTNVVGLAWFALKERQRTATQAHCTGDDWHLTPRTYDLEGNTMTGAENGSALNLFVGEQWPAPGTDSQTCYGFTLPAMNNIIGSVVPAPTSPAILSIGRMALQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWU7</accession>
    <name>K1VWU7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-vacuolar targeting-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWU7"/>
    <dbReference type="FunCoup" id="K1VWU7">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWU7"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080826_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWU7"/>
    <dbReference type="OMA" id="DMIFQLR"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="265" mass="28903" checksum="B8F13BF5575DC936" modified="2012-11-28" version="1">MGDPSHRTPPTLGVLQVHLAICHRRIDTTSTMSNLESSFPAQGVSRAAKFVLAPANAQFTAKSLNRQAKKANKDETAEKNKLKAALQKGNTEGARIYAQNAIRKKTEALNLLRLASRIDAVASRVETAVTMRTVTNSMGSVVKGMDKAMESMNLERLFEPHGGLANMQISMVMDKFEAQFNDLDVQTSYMESTMSDTTALTTPQDQVDGLMQQVADEAGLEIQHGLGEAKVPTEQIAAPATPVAEAPLEEDGRLAERLRALRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX43</accession>
    <name>K1VX43_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX43"/>
    <dbReference type="eggNOG" id="ENOG502RBAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457226_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX43"/>
    <dbReference type="OrthoDB" id="2563819at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="597" mass="65086" checksum="BA9ED856993617BE" modified="2012-11-28" version="1">MSALAEPAHSLPLASTSSANGSSSGVAQRPHTSSSDGDDQEHDFDGGQDSSDSDDRPTQDGPGNVASDTGGGGGSRAAKRKRKNVSRACDRCRERKIKCSGDEPTCKGCDKSKKQCVYRAHVDGRMTDKSAKRKFQTLHMRIRQLEAELADALKVANAVPGQTTEGGDGTQSGAAAAVSVSRAAHAATVGSPLVDTNLAHPPTTAPPRDYGGSDPSLADRPDCQPFGTGRLVLSQTGNLHLYPAATFYSPAYLAPDWQKALEALVPRPPSRPGYLAPYLPFPLDPVHHRRLIDLCFDRMWSFGSMGRGWYFSPMAHLAVLAVGWRYFKDPAVGMYYAQENVGARGNAFAQKALERLWDEVADPRLSTIFALVTLSIYYTGMQGESAEDNVSGWTAHSSSPVASSLYYWRLHRRCDQQLAELGLGVDSELDIARRDVYGAATNLSCWYATYVGQDPLPLRDQADQRLPFIRKDLFDPVERDISEMFHYHVALSDLGLQALHCNHTLRAPLEQRVERVRRVWKGLDACVADAQAQGPAREPALAAARGSQAAPRAGHESRHVRNALKECLSCAADVVEQSKYIERTYGSITCAPMSWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXR4</accession>
    <name>K1VXR4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXR4"/>
    <dbReference type="FunCoup" id="K1VXR4">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXR4"/>
    <dbReference type="eggNOG" id="KOG2698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708202_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXR4"/>
    <dbReference type="OMA" id="PNGGIAD"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="12">
        <location>
            <begin position="208"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="390" mass="42524" checksum="01C92030E1C37EA8" modified="2012-11-28" version="1">MSGKPVNEASSKAQPQPVPNLNNLSRLSESSTGDWERGKPSGNARSPKATTSVLEQAGAQLDKLSIGDKPPQAAAARPAHVQTGFVPDEKRSQSPLHPRLQREGYGFRPASGASTPTGSHANPLSPSVGAQSTDDKELEDEELNAQLNDEVRNALKEPVTTLATTSASTELLPPGGIADANGLAKRTHLRLQSTPEEKAKNLEVLAGALRTVLECIGEDPDREGLLRTPERYAKALMWMTKGYEERLVDVINDAVFAEDHEEMVIVRDIDVFSLCEHHLVPFTGKISIGYIPNKLVLGLSKLARIAETFSRRLQVQERLTKQVALAIMEAIRPRGVAVVMEASHMCMSMRGVQKPGATTVTSTMLGCFRTQQKTREEFLTLIRTPSMTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXW8</accession>
    <name>K1VXW8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXW8"/>
    <dbReference type="STRING" id="1220162.K1VXW8"/>
    <dbReference type="eggNOG" id="ENOG502S4IY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496241_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXW8"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="551" mass="59879" checksum="0F79DCA82A542D20" modified="2012-11-28" version="1">MSSIASSPTLGPAHHADQSIFRPYPTGLTFHQKFYIFFLQGAGFIDFGANFGIAYAMYHGQSDVRLWVFSKNTIAGDLGVTPIIQCAASMVISSSLVHTDLHHRAIRPLPFVWPHVQHLPDPHYIFDRIFRGRAKRRAAEAERKAVEAGLPGGGEQCDYWENQPHGFKFYFWMLVRFAFEGTEMNMLFERCGFGEWWLRLLWTAAQGALLGIIFGLPCWILAIIILGPIYRGGNMGNVWAPQAIKGVYGCIVGWITNPIIASLALGGQSEHHLLVVPEDKEAQVVEGREAADASPAIDTIVEEDVVDGTPVESQNPPSPFLRPFRQVTTTSGLSVPESSPGVSGSPGRPRAHSLTRPISRTRTRSSSFGHTPFTANAAQLGPPSPIIPAVPSPQRLNSTPQRPTRPRGLSTSAAPGPPGPFNYALGGVGGRARRGRSNTTTTVTEIALVQQRKPEAPSPTPGADRATDNLELVPPPRLGGRERGFSDVAGGASHQAWAQGVRQSHDGGERLDAESRPRPDIPQFRIQRPSMEAGTEPFVDAQNGSNNVQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYL2</accession>
    <name>K1VYL2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYL2"/>
    <dbReference type="eggNOG" id="ENOG502RBDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_880043_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYL2"/>
    <dbReference type="OrthoDB" id="3257643at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="30753" checksum="F56C1CD7D4CECC33" modified="2012-11-28" version="1">MQSSVGPSSGGGVPPPGRGPPPPPGHGGGPGGPDDGDNRSRNAKAQRRHREKRKAHFKALEESVQVLTAQLEEARRQLANAAYASSSRMVYSPDANKDVAQLANEVAYLREENNDLRRQLYALRYARGESTSSGMVPPSSAGDPQGKVTTGIWPEVKQEGAYVYSTPVVSSPRVASSHGRTMSHPGDFVRSPYVPSAPFPGADPRTAYPPVRYESAVYPAPPPHSLPRSAVGSSGSSGSANYQQQQVYVPQHAEGEVAWSQDQPQTQQSTMTQPRYFDPQQQPPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZX0</accession>
    <name>K1VZX0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_03342</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000290">
        <property type="protein sequence ID" value="EKD02363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZX0"/>
    <dbReference type="FunCoup" id="K1VZX0">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZX0"/>
    <dbReference type="eggNOG" id="KOG2629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045718_1_0_1"/>
    <dbReference type="InParanoid" id="K1VZX0"/>
    <dbReference type="OMA" id="YNQWQPP"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="117"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD02363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="30854" checksum="468461CDF3782EF6" modified="2012-11-28" version="1">MAQKVEFLQGKGLTDTEIQQALSEAANGTSNPSAAIQSPAPAAPPAYARPQPSYQQQPHYGFQAAVVAPEPPKRDWRDIFIMAVVSGGVMYGVTALARKYLVPHLKPPSSTAFQSTSAELSEQYDAAAAALDELRAETAALATAAQSERERVAAALEDVESAARAVKDAEARWRDDMREVRGEVESVRELVPRMIEKHAASQSAALTELQSELRSLKTLLVARQGGNTVSEAAASGAASPTPSATQTAANALLQPRGKASIPAWQLPNGGASAATSSAVSVGSVPSDAGSPTKETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0B1</accession>
    <name>K1W0B1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0B1"/>
    <dbReference type="STRING" id="1220162.K1W0B1"/>
    <dbReference type="eggNOG" id="ENOG502TKMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811794_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0B1"/>
    <dbReference type="OMA" id="EIQMRAQ"/>
    <dbReference type="OrthoDB" id="2576495at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="342" mass="37235" checksum="EDE3938A39BAACB5" modified="2012-11-28" version="1">MIDSEKRAQKEAARARAQKIAEAKAAKEAAKAPKTSKKAEKAKRKRAEPESASEDEGSEDEEEDEEAARLRRRMDAAMAAGSGDSEMESDGDDESGLESADEDEDDYDDAELDDEDMEDGESFHTASEDEEEEDEDEEDDGAESDESETLRDGPLTPKEIQMRAQMDAIFAAMNKAEGIVPPKPAKADKKGMGTSQDVPEPQVKKAKKKTGPMTEEDENALYDLSAGVPLSAAALEEAEAELQSKKKKAAGKQEQEKRNAAAAKKRGNKRKRRKTETVEKDLGGSTLHLLQPVLSAGDGLPPVIDAGSQQKRASAKSRFMKNAMKESGRIPGKAILDGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0Y0</accession>
    <name>K1W0Y0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0Y0"/>
    <dbReference type="HOGENOM" id="CLU_582907_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0Y0"/>
    <dbReference type="OMA" id="KWRIATD"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="469" mass="48871" checksum="456B1109152AC598" modified="2012-11-28" version="1">MTGTLSSASSSTSRRTSFSSTAPPPLLTPDVEFPNPPLMAVFAADAADEPAAIPLPSNPVKPTFDPAPSPSPPRKAPVEALNIAGTIKEIQEQNAASSFSSSGSRLTSTPTSELGRFDYPFPETPAEPAPAAHHHRPNTITSRSSTTPTTARPARPADSFFARPPRLGRRGSIASGQISRLAARLPDGVSVREQQRPRSSSGSSSSPPPQVSPIQHEKRRCASSSSLSNLNLLATTNNPGISPAVEVSRPPLGPSSLSSTSVSSYEITTPSTPSSATSTLSRTVYVQPASWSRAPLSFQHAPMPAPIPPSLLARRGSVPANTLLGLGPPQGGWSNSVYKAVYHTPAMRPRKLSGEKKRTAQSPQTSIDLGRRAPTTPLGTSPARSAPTPSPAHSAHSNYSSSDRDTSPRAPSLALPSPVVQYPALSPFVPYPASLAPAAKGPAPPPTTSSTSLPLETIPSSSGEEREHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W112</accession>
    <name>K1W112_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W112"/>
    <dbReference type="STRING" id="1220162.K1W112"/>
    <dbReference type="eggNOG" id="ENOG502QQTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029283_0_0_1"/>
    <dbReference type="InParanoid" id="K1W112"/>
    <dbReference type="OMA" id="RWTRRIY"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="6">
        <location>
            <begin position="124"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="514" mass="56435" checksum="5256CEC05C155C0F" modified="2012-11-28" version="1">MEQVPEYIDIPIGATPIPTPRELSGPAPVNGDVRVNGVNGVSEVNGRIPVPGSSFPPSHSTSTPQKKASIGSTISSNVSDLVLSTILPPNLPTLPSPPHVHGKARELTTQKNGLGLNVMTVNFRRFVTKDRVEEILFWHKPMWTWAFMATWAFICFNPRAVLFFPTAILLTIYLNFQEKKNPIPSLLGVTTAPADLGTHRVGNSASTSYSASTAPDMEGAAVVPPKEAESSVDYFMNVQAIQNLMGLVADGFDLLAPVFSYLAGETATPTSFPLAPAHIVLALLPPSIALPLVPAWIFPWALLPVGIVPPLLFHPNLVTLWGKIPHARALRVARHHLEDAVLTDCLTDDIGSKRIARVQVVENERLDPSVASKNNSNTTNGWSSRFLRTGERLPWVKIRESSAWARDDLSPHAEDDGKMVLALEKGWKFVPGEDWRVDVCALWSESEPDADGWIYTDDSWSNPGPQVVDDPTVLPVVSKRTTRQRRWWRRVYFDPVEATAVPAAPGFDTKPKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1A0</accession>
    <name>K1W1A0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_02998</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1A0"/>
    <dbReference type="FunCoup" id="K1W1A0">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W1A0"/>
    <dbReference type="eggNOG" id="KOG1355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1A0"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="17"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="18"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="304"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="418"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD02768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="430" mass="46726" checksum="070746027CAA38C1" modified="2012-11-28" version="1">MAQAPEGVTVVLGAQWGDEGKGKLVDILAADADVCARCAGGNNAGHTIVVKNDKGEKTTYAFNLLPSGLINPKVEAFIGSGVVVHVPSLFNELDTLERKGLKVADRLFISDRAHLVMGFHQIVDGLKEIELGGSSIGTTKKGIGPAYSSKASRSGLRVHHLYDPTFPAKFRKLVEGRFKRYGHFEFDTEGEIEMLQAFAERLRPHVVDGPTWLHKKLAAGKKVLVEGANALMLDIDYGTYPFVTSSSTTIGGVCTGLGIPPFAIKRAVGVIKAYTTRVGGGPFPTEQLNDVGTTLQEVGAEYGTVTGRRRRCGWLDLVVCRYSTMINGYTSINLTKLDVMDGFDEIKVATGYKLDGVEIEGFPADLDRLAEVEVVYETLPGWKSDITGIRSFEALPENCKKYVHFIENYLGVKVQYIGVGPARESTITVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3K8</accession>
    <name>K1W3K8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3K8"/>
    <dbReference type="STRING" id="1220162.K1W3K8"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1397226_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3K8"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="195" mass="21581" checksum="EEA1F00D6871BF16" modified="2012-11-28" version="1">MGRPVPPACDGQLSSRAFRSPQPPNHPPWRTHFWGPVANWGLPLAALSDVFNKDEEYISGVMSPTLAVYSMIFMRFAWRVIPRNYLLFACHATNAAAQSVQEMRYINYWYFGGREKKHPELVAADAAKDASQEIKDAAALIKQDKFSAAGDDLKQAGKEALHAASAGAEAFSKKGQEVKAEVESKVQKEIDSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5J0</accession>
    <name>K1W5J0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5J0"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="K1W5J0"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="285"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="528" mass="56869" checksum="7F5D1C1C7AB867E2" modified="2012-11-28" version="1">MHRPEHNATDDMAARPSLSAASTTSTHYDEHTHHLPSHHHAQHEPEEDLEYIQHMPPRLRTSIDSGLAVEYAEAAAAKEGDHKLDKLEKFVEKEPPVTSGARPPKPLVDILEPAPAAPLERIASVGPPPDGGLRAWLVVMGSAFSMFCVNGFVTGTGQFQSYYLNHQLSSYSPAEVASPSPSASLSFLVPCLTRTPPDRLSSSLRWDSSALSLPSLKYYQFLLSHAAFGVAGAIIYSPASGIAAHWFLRRRGTAVAVIMSGGGLGGVIYPILVKNLTDRFAWRDAILILAGIHFCLMLPPCLFMKKRLPNRPPVPIRALARPWKDVRYCFLVLGQCIANMVVFSPYFNAGLYASSNGANATIVGYAVTILQSGNVVGRLSSGPLADRFGTWLMYVASAASCAVALFAFWIARMNEGATVAGLVLYGMVSGAQLTLPPAVIATISPAHEIGMRVGMLWTMLAIPMLVGPVITGELITAAGRTYKWAGLWNALMFCVAASLLNLPGVLKWFRDRKAGKAGSNDIAQPETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6I2</accession>
    <name>K1W6I2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6I2"/>
    <dbReference type="FunCoup" id="K1W6I2">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6I2"/>
    <dbReference type="eggNOG" id="KOG3332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034979_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6I2"/>
    <dbReference type="OMA" id="HAICISD"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="382" mass="41909" checksum="611026FC2536E3E1" modified="2012-11-28" version="1">MSLQTTGDLFHLIFTPTLPFPFGYIPYAFRALAIVMAAPFLFFMALDLVAYAITRTLHISIERLRVPASPPSSSRRLPDVDEQPDDIDIAAELDSPQRKTKPLPDLGSGKAFSPVLALIVVLFAALLQWTTTISNDAQLSALAGDVAKPRAAVLTAHPDDEAMFFAPSILSMVDAGWDMHAICISDGNADGLGLIRTEELYQSYTRLGLKADQVSLITHPSLQDSMNASQMWDSQLVANLIAPYLDRNGITHLVTFDNQGVSKHPNHIALADVHAHLNPYLDSADEVPRPVLLQLESPPLATKYTGPIWAVVCALRELAARVLGSSPEGDAPEAATLISSPVRYAKAIRAMLAHRSQLVWFRWLYVSFSQLMWVNRLIDLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7B8</accession>
    <name>K1W7B8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7B8"/>
    <dbReference type="STRING" id="1220162.K1W7B8"/>
    <dbReference type="HOGENOM" id="CLU_621412_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7B8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="44"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="448" mass="48702" checksum="21CAF992E94CA49F" modified="2012-11-28" version="1">MLFPTSTFILAGVVSGSRHALFNRQDGGNGGGTPIDGLSTWFAPSINISIGTPPQTVLASLDLLYGLTRVAQGALNTDESSTFRSTGNVTVMKSQKSSEKVNVPTATDHLAVGDWKVDNAPLWFYTPETREPYQASLGLGWYHPEGQKSDPLWKAWKKPLMGLFLRRAAIQGPIWSQNVSHTPDVGSVSFGSIDEAHTEGELQWITADGLWNVRLDNLTLNGVTANVDLVRRAKPVDVGASYMWPLSDGDWGERLIGITLNQPFVGLPSAMVDGLMSTVPGAAKWNRTSAKYKPETFWSVPCDAKLDFSVTLNGTMFSMAAEDLIMREENGNCTALFSSVVEDGTWKSVPFLGLPFLRTVYSVWDLQNQCIGFSEVKNEGELLNMTTFASPLDNFSTVPVQPTTTGRIYGEKHSSSTTKEPTSNGDSSRVVVSLTLFGASAIIVLVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8E5</accession>
    <name>K1W8E5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subunit of cleavage factor I, Hrp1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8E5"/>
    <dbReference type="FunCoup" id="K1W8E5">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8E5"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_0_3_1"/>
    <dbReference type="InParanoid" id="K1W8E5"/>
    <dbReference type="OMA" id="HCEAKRA"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="136"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="466" mass="49418" checksum="104B51DA41814CEE" modified="2012-11-28" version="1">MSEFDNDLYGDLDLEDLDATQLDEELVDPDQEKQEDNKESSAPHDAPIKHEPAPAAAHDSHASGSGQHGGNDGYFENRMRPSDMPDEGLGSWVAGSLENHMIKRDGSGLGSRPCLEAGKLGWHTRGHRERITDMTDGLRSYFSQFGDIDNCTIMRDPTGRSRGFAFLTFKSVSSVEAVLAKDHQLDGKMRAIPRAEHERTAKVFVGGLAPSVTSDSLKQFLSQYGKVMDATVMFDRLNGRSKGFAFATFADESGVENAMQHSGVELEGRQIEIKKAQPRGAGTQVKTFNAPGGARTSGFNATSGMGMGGGFDPSAMAMMYQNMMKGNSMGMSGGMSGGFDPSAMAVMYQNMMKSELAPAINPNMAQRGNMGMGMGNNMMMNPMMMGMNPMMGMGGMMGGGMMNNGGGGGMGRGRGPNAPRGPSAMRGGGPSGMAQPMAQGSSHGGNGNGSGPQRYSTQGSQRAKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9B5</accession>
    <name>K1W9B5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9B5"/>
    <dbReference type="eggNOG" id="ENOG502S31Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359412_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9B5"/>
    <dbReference type="OMA" id="HHASAIT"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="5">
        <location>
            <begin position="653"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="572"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="293"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="770" mass="85092" checksum="F481F64CEEE1E634" modified="2012-11-28" version="1">MDAPPILPSSFDLERQRLESTLDHDLSSLSLSMTGTTSTSFASSSLSTIPVGRAAVAPMPQLDEYPRFPTHHDRTPRAFKKPSYDNRSETSVGMSPASTAGHHISAVTLGASVFRRPGADMSERTEEFDPDRSLGRLTRELARTMQKEAIAPKPASPFRSSHPHSPRSPSPAPSVLPNLSLSLGRQDPLPSPPNSRTVSSASSNSQSYGYQNQKSYVSGKRPVLVETTNRQTRVPERVTSQPKNIRQQQMNDSADVTGITALLATPAKGMGMSDLDKNGGPVDSAGASIPQSLASLQGRLRALETENSVSRRRVRELESEIERANQEIAEARKSREAEAQLPLEDLVESLRAHLARLTRELEQNKALVSELRLAAEAESRAPPSPVRRHDDSKEEIAKLWDEVDRLTREVNRLNDIAERGLAERTRSREERSMRIDALDLAEDADTPRRETTKRVEFSLKPSQLRQGLHAAAAADTHLMPPSAKSKRVTSQAPDVDSTDGYESPTPSTPVSRNTRSASNASNHSVRSNRSNRSNRSHREPEGPSSPFPSIRMEDEPEFFSPVSQRVDRAVSPLAAPERAHRASSPITSPLAERRERNHRGTSPLASSPPLNADDSFVAEPSRPAKTQRRKVSASKKLPRGAPASVRALFKDGSIPPQTVLTRVISELEADFHHFRMIYIELADQYKVLDVACSTEKRQVLAEHLKEVIDSMERKAEQVSALYSLMTVEDREDDVLPQPPARSANDLWRSVRNSLSEEARRRLEADGLFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAA5</accession>
    <name>K1WAA5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAA5"/>
    <dbReference type="FunCoup" id="K1WAA5">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WAA5"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038177_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAA5"/>
    <dbReference type="OMA" id="VEWNVME"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="361" mass="39270" checksum="AFDE7A9715FC044B" modified="2012-11-28" version="1">MPFIREKDNQPITRNRTLFFLSVRDTSTFGSRRQAGPSYGADVAEDDERGGLLREHRVDFSQGLPPKCDEVEDILNRVKGKVAALDKLHAKHVLPGFNDRSAEEREIEKATTEITRQEFRKASNLIGTITPEAGAARVERLTAKNVQRGLAQKVQEASGQFRKKQRVYMQRHQIKNKDLLAASGAISLRGNEGLESLAEDEAAVQLQSTEYAPSVDIQQRTNEITQIATSITELADLFRDLSGLIVQQGTVLDSVEYNVQQTARQMDDAVEELKVAKRYQSNTGKRKCILLLILIIVGLILVLIYKPRRSGGSAGGGGNTGVGEGGKVEKPGNDGNIPQPTQGSAVGGIGGADMGIIDGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAF0</accession>
    <name>K1WAF0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAF0"/>
    <dbReference type="HOGENOM" id="CLU_924978_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAF0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854294" evidence="2">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="301" mass="32671" checksum="744DAF629CA3B478" modified="2012-11-28" version="1">MRFITAPLLLSVAASAAVIQGRNREFGPCAPGDNNLEARNREFGPGAPGHGCPDIEARNREFGPGAPSHKCDDVEKRNREFGPGAPSHKDCGDLEARNREFGPGAPGRHCQEARNRGFGPGAPGHGCGDLEERNREFGPGAPGHSDCPPIEARNREFGPCAPGHGDKEKRNREFGPGAPSHSGTPNLAERNRGVGPGAPVPEGQQYCNITNTPDARSYRCNYDQPHPRSGCEKSNDGPVRVYTCPPVPEDLSWCDEEYRTDVNEYVASCTKDYRFNDGCKKSRDGDRYIVTCPLDTILTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAP9</accession>
    <name>K1WAP9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Siderophore-iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAP9"/>
    <dbReference type="STRING" id="1220162.K1WAP9"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734007_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAP9"/>
    <dbReference type="OMA" id="NTIRITF"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852373" evidence="7">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="377" mass="41688" checksum="DE0CC5ED6A4BD82E" modified="2012-11-28" version="1">MVLLVGGLCLILVPLTLAKGVASEWDGSNIAMLCVGCVLTLFFVLWSLPKRWRPKWLYKPSQPLIGWFALKNRSLVAFIIINGCDFMSYAIIQTYAQSYFQVAAGLSAARATQVDNTIRITFQVFALAIGIIMRYWTWIARKLGFGPNRHFHTAWAIWFGIPVGLLSMGLDIYFFSRPRASNAIGCFVGAKVMYGFARAMFQTCGQVQIQAAAKRENLGVATGIFYMAMSLGGAIGTAVAGAIWANDLPDQLRANLPAASKALAPKIFGSIKVAMEYKYGTEIGDSIIQSYANTMRLLAIVATCIQVPMFIAMFFIHDIGLTEDEQIVEAGRRIAMAKRSEREEIEKLEREKADKLDKEDAYAATPSDTVDNLNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCS8</accession>
    <name>K1WCS8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCS8"/>
    <dbReference type="eggNOG" id="ENOG502RB85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529123_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCS8"/>
    <dbReference type="OMA" id="ESHYTND"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="515" mass="54032" checksum="1C7796E02B6B81CD" modified="2012-11-28" version="1">MATVAPTPTLARVERDSIITVLQTIPAETPTGAAANKKEGLPVAPIVGGLVGGIVGGLLVAGLIVWFISKRKKRKEAARKAYMKRQARLRQSKLGSKTPSSGHSATSSLSSHQRLTITPTPSEKLIDFSQPAPAPNRPRAPSATYSSPKIYDRFMSEKGYGYEPKPLDYVDAGGEYLVQEAYESETPAADASPRQFASNNPFNTSPTRATPSAMSQVSNQSFYTAGSRRSSSGSSGSSAGRISFTGSLQSPSVHSAGVKAAVQRSPPTAFSATVPPGSSAPSGHQRRPSKIKRKEPPQLLPPLDLSAQLPQAEAVANPPADPAKAAAQAKRKSRVAERSAAADKAAAKAATPLHVRSKPARPSPLAKAQQDLDENPFNRPGPSPQSSISSQSMLSIAPSFESGTTSGYSPSVAAAANDAASVGGTYGIALGSPTHDKLDFSAQQEAAIRQAQAAMEGYDSDSARNDRTNSGQYHYDPFAEYHKPTANGGAAPHNETVESLVEERQGAGRKLSKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE47</accession>
    <name>K1WE47_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE47"/>
    <dbReference type="STRING" id="1220162.K1WE47"/>
    <dbReference type="eggNOG" id="ENOG502SBHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173512_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE47"/>
    <dbReference type="OMA" id="WSYWAYA"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="95" mass="11021" checksum="2A15392641875CA4" modified="2012-11-28" version="1">MPIEWPSASPPSVDGSDDNSLSYPSSEASFDSDDQHALIQEEWEESMRQLEMVFSVILLPFLGKWWGRKFAFWAFDRYKTLGWTRQFFGLAASTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF66</accession>
    <name>K1WF66_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-intron endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF66"/>
    <dbReference type="STRING" id="1220162.K1WF66"/>
    <dbReference type="eggNOG" id="KOG4685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512089_0_0_1"/>
    <dbReference type="InParanoid" id="K1WF66"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="532" mass="56945" checksum="90DD16B1B9D3BFFC" modified="2012-11-28" version="1">MHYSSIVRRQRAQRAAWSSVLPPTCSPDTHRSDFSRPATTIYALRNPLQVWSPNNILDPGDHLASILRQGDSIPALHSATTPRRTPSNVGAMSIPASVPAPVGPGGFQSKGRARAAANNKKYGTPLPILLPESPLYAAALASPPPNSTVIRLGLFTSARAIVPTVIGVLDRDTQSVFVSDPDDMRLLFERGFFGKGSLSRSEPSWRDGRRELLKGGNAANAEKIREQRRKERKQFKIDRAAAMKEAAIKAEAVVAAKKAAGETPRPGTPKLDTPTEEKDEEGGDGEKEGKEVKEGQEAEGDDLDVNALTPQTFLVRPTRPDANRNRGKKAFRRKPNAPTTPGGAGPSTSGTPGTATPAKAAEVAAAEQAGPTEEELAAQAAEKEAEAQRRAEERAKDAALTETVAELVDEREHLQLSYPEALFLASIGVLKIHDPEERNGVYLADQEKDGIDRGDGSGGGETGGNGVLRECGGYSGLRSVDEVSQPDGNTEEGRDWPELDDRDTIGAVIRHSAVPPPSVTADHQPRPIYHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFD3</accession>
    <name>K1WFD3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFD3"/>
    <dbReference type="STRING" id="1220162.K1WFD3"/>
    <dbReference type="HOGENOM" id="CLU_516991_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFD3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="56686" checksum="3EE3B25883D9E104" modified="2012-11-28" version="1">MSVAADDSDCKIETAGSGSAANDVIDITAELHGAAGSLATESDIDAFFNATKGTAGDTAASPEDHAANSTGPQLDMAEAASEVDDSPGSVKNTCEVGEGEGDDAEVEAEDASELSDPVGFGEEASREANTDEANDDAEGDGDEYCEEEHEEEEDASGETDTGSEYTPEVITKTTRRSTRTRARAQSNVANQEPQTCEGLEESEEHKQEQPEEKLTNPKKTAANRRSGRRGKAVKSEPEPSEEPQEDGQGNADPVEPMQESESEAAPVKRRGGRKRAQPAKVGSPSPPEGPKPTKRSRKRKEDKQESDHDDVKPAVGEDGSVKRGKRSRRAKEKLDLDCDVEPGAEEESKPARRARASRSKKLKVDVQPETESAEPANGRRAKSEPLPGAEAKLSPDLKPRKSAKASKSSGRPAGRWSPEDRTALYLAAVEANCGGKVRTERFQAGVAGRNAKQCFDAWQKTAEPFIMKYLSEEPKPVPKDWRAEPTGRKGWDGAALQALFDAAVGTETPRFAEGINGRSKATTRDTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1WN92</accession>
    <name>K1WN92_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WN92"/>
    <dbReference type="eggNOG" id="KOG3975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_804567_0_0_1"/>
    <dbReference type="InParanoid" id="K1WN92"/>
    <dbReference type="OMA" id="ARICAHW"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38477" checksum="DC8A161668F2653C" modified="2012-11-28" version="1">MDPRLAFMRSAKPVVAAGTKTVPIRQTFSSSTPRDNTVSVLYYPPKRGTEQAPDQVTLFLPGNPGTPEYYLYFLGHLHSNLPDGHALLAASHVGGDAAQPHPKKPFDLPDQIASKIEMVNALQSSLDAWASPGQKPKVALAGHSAGTWVICEIMKKIKVHAAYLTFPTLGWIAWSYNGWTMWPMFHFPILQIIPYTSYIARHLLPYYRLPKPSQELVKSPETLRDVLAMAVSEMKLIREPDYEWFLKQRDLPYGEGVHGVWSEGTLDGWVGKEAPLIRDCLGKDRAVTVDIPHAFCLSERKSKRVADIVLGWMTDKPSKTVAAVKSANVHDGTDTPEYPESEMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSF6</accession>
    <name>K1WSF6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSF6"/>
    <dbReference type="HOGENOM" id="CLU_2741842_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSF6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="71" mass="7691" checksum="B1617B0F2206E1C5" modified="2012-11-28" version="1">MSQLSMEMSSGTGHVNSQSVTFPPAPTTKTVERRLRSQSGQQVSSQLRFKLKFSLVLSGTVIQRGPAPGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTQ1</accession>
    <name>K1WTQ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTQ1"/>
    <dbReference type="HOGENOM" id="CLU_839888_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTQ1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="386" mass="42883" checksum="520782E091C90FC0" modified="2012-11-28" version="1">MHPAQRTRHIGLNRCEQPLLSLITPLASSERRCLVDTAYSRPLCLTATSTRQDDRMSGNHHLQDLKATYTAYEPYLDSSSSGTSSSASSRSVSSLSVAEQEKLIAALKGLHVRTHDALLALCCALDIEGRRTDPDAKVQALMVQAWSGLNRTKKLRFWRRNPLCAFPSSLETVLGGVAWSVGGDMRGSFLQCVFALCASPDLENSGGVALTTSSFALMWRTIDGLQLECNRHWAEWLEGRRVSLIDLLENDDFWDSAPFRWQNSHSEVNRLLAFVDARHCPFQPTRMHRRPTAARPKPPKTAPSPLSEKSDSALVKRMSVFSALPRVDYDACDTHAPAHVDKTLVKRIKTVLPSGECEAYVDLGMPDPRVIAAAFANLTVEFRHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXM5</accession>
    <name>K1WXM5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXM5"/>
    <dbReference type="STRING" id="1220162.K1WXM5"/>
    <dbReference type="HOGENOM" id="CLU_056053_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXM5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="395" mass="44966" checksum="D44E64E6568BA28C" modified="2012-11-28" version="1">MPVFLTYEAYPNIFDAIVAYSDFATQLTLRFVCYSLRGAVDRRHVHHVFLTPDGFHGVTIHGSTHRMPALRDFSFELLSSLLKHPPARLFKHTRILDVRGLFPQQCYLPALRSVFSNISVLRLTTISGTYSPYVPFGAETLVLFTSPHGPDCEANPRAFDNLRSAGLTDSSPRPVPQDVDWRTVPGTVKRVVINMGGDDQPAADLWPFIAIPPPHITEMVIIFPRVLRSNIAMVPPFSFGRTFFYPDIVAEDIAETLDGSDPRLRVTLVGFELWRIQGLDFEKLLRDQLFYSQLQGVEYEKIGFTIDFDEDGGRKVRPIAKNAAAHERMVRQLMSQVEMMTWEEYVESVGAERARIETVEYEDGTRRETRRPQGLPNDLRRERTRLAKSGLVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V256</accession>
    <name>K1V256_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000399">
        <property type="protein sequence ID" value="EKC98009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V256"/>
    <dbReference type="STRING" id="1220162.K1V256"/>
    <dbReference type="eggNOG" id="KOG1902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301719_0_0_1"/>
    <dbReference type="InParanoid" id="K1V256"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="424"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="598"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="789"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="932"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="108089" checksum="1743E865669A68E9" modified="2012-11-28" version="1">MASPLGGQGASSSPVSQSPSDTTLRRASKASIHSHSKGQYDGSGSGGDKPMTTKQSRQQHKEAPPPHFAVAANHGSRHGVPVVMDPGACEEGTHGPERADPFPDQHQIHVPTVIYPTGDSRQPYLAASENPTAARRDDQPHQHQRQHPHAHQHQQHHMHPAAVHGYTSADPSQYMAPHAIATTIPPDSVRYTEQAQYPAMRPAMYPPQIYYTSAMGAEFTVDPNQTPVYSTPGMPAARTSTFPGQATYHAAPATGTVPPQAAWPGSAMAQPFYGTYPAIATTAPQHAAPQPPIPEEIARQNSVFVPPGTGWSPSTVMSTPYQFYNPFQTSSPQIDKHIDPLSPSTDAWSPTLTGPGSSQPGGPMRRGSAVPQPSWPPSVSVPSVRPPQSSAPGDEGPKSPPHAGGPERERKDYHPQPPARRSEWVMWVGNVPSNVSHEELWRFFSNTVPPPSSPNVEQWRGPSSIFLISRSSCAFVNFSSQVDLDRAVPYFNGLSLRPWDSRCPRMVCRIRHKDDDLRSGVGAQRGVGMHRAWVEQHKADKHENQPPRRMPTIGVSPKSTMLELPHQEDSQHDSSSAHKSSASYASTNSSFLVHHFPERYFILKSLSADSVKTGQWKTQRHNQPILDQAFRTSKDVYLIFGANRTGEFFGYAKMTGASRKHKPATERPTPNRGSYQSARSSMLGLSTSPGHQPAPIREEEEKESGSPTQELLSPTAQHRAATYQPRSQTDPFLLGGHLAPGLDERRATSPGMIPVEEEPEQAVEQVTVEHVHAEQQVGPFIEQHDEFHTQHIMPRSESPDLMDESIRRMSTMTLDPNILRGERADSRIRLLSVEHSNSLQVFSRRENTAEGPRPGRQATLAPPGAPTNNGSSGSEAGDNSLAQPFRVQWIKVAPLSFSRTRHLRNPWNGDREVKVSRDGTEVEPGVGAALLAEWDKLDQPATKAEEGKEAKADPDQDKEVKGDAVEEAPAISATASTASAAEGEGEEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3T4</accession>
    <name>K1V3T4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3T4"/>
    <dbReference type="HOGENOM" id="CLU_103060_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3T4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="164" mass="18437" checksum="206F564945A3096C" modified="2012-11-28" version="1">MPVNDTCPLESAFQTVNSSYNWTQAYDKYNSNEFDVEQQDRLEKLFMVNSDPGYNWGTMPGCFYLGTLNRTKVDTCQSYGGMAIMNSRTKDIVDADVWYCGLRAQDYDPRKDTDTINARISELRSGMSDPAITCQVPGSSAARRIPWSWSPLLFVGVTSLVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4L0</accession>
    <name>K1V4L0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4L0"/>
    <dbReference type="HOGENOM" id="CLU_886196_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4L0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="314" mass="33886" checksum="40B97DEB515662B4" modified="2012-11-28" version="1">MESTKKRQVKRDPDSPPADENPTHGDKDVKPKITAKKAKGPQPYAPGAKSSLAEMIIKIGIAGLPSHAEVCEKPAPHAAGSPLGCASRADQVRRVAGLSHTDAKVTIALAPKRVEQAALLFRSIASIMKREADAEPTVKHESERKRKARGGEPCAKGARAALAQMIIDIGLAGLPAHDEVCEKLKNQLDARRGVRRDLTKFAESLNIHTLHLYLASIHSHHDEAQIVRHTFRGRIQARPLRRGRQAPFKKSKAKAKPGGYPAGGKQALAELIIELGVKALPPNKEVANASQVTTQLDPRSGVRCNLVKYAKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V795</accession>
    <name>K1V795_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V795"/>
    <dbReference type="STRING" id="1220162.K1V795"/>
    <dbReference type="eggNOG" id="ENOG502QVFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332385_0_0_1"/>
    <dbReference type="InParanoid" id="K1V795"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="94486" checksum="79B28FC1F644ADB9" modified="2012-11-28" version="1">MPDSESLPLVVCATNAHALAVWLASRLASFGNARVLSHPPTHSRTEFAPRLINAAGFLALLGVGLTGNMYYLIQYGREPGSGRVIGPGVDVTARAFSFVLQVSKRTFQTIHHEQSRRPVLLVHTAHVAGDRRAAPVPPGPQPVPVSQLGTAQSHGTGHVSFRQSFGTSTGRPAAVDYTDSPLGTPPLHRQGTHNTHDDSGFGFSVSSGDSDMLRRPRRRSSLTGPKYKWLSNNTGDEPGVDVRSERDEEMYKHLRGKANVTVSCPTFVPETDRQVVDYSPDAEAEDSNVRIDISGERFEHWLESDEGERPMVDGKPVGVRWTDSSLHPLAVEDALRSESSPRSKLDFYRNHLYLQILVQHIYDPDEETFEAEVDGVDNGTIGDQDGMEAAAKRARRWWQRRSNSGQIRLPEGADNVFEPSIPESEHTKKTSAPNDKAKHRFVIDQLSASYMVPIRRDILSVFMLRDGTVISVSKTPVMEVLEPIYERLEDEHSLLRRSGDPSMLIHALLDVAVDLSVEITQAFEAEILKAESNVLVQADLDLVRHLHIVQAQITRFRRSLTTLLHVCYVLRDQDTIRTLAVGNLSKKNGEPGLQVPNVPVGTAGYAPSAGSSLHGSPHHNNVSGPGGQSALNTSGMDPSRRHAGGDFGGAGGGFGGGAGIYQPTPMPAGYAMPGVPGMTAGTGVMPTPNGTPPPGSAIGSAGYISPNARVYMNDVIDHLEVSYRCNTGEADRQMVASSSDQFVATCDHLTDYSFNVLSFYTNNSMERLSIVTVVFLPLTFIASYYGMNFEDFPTLDNPDSYFWKVAAPCTVSFFVIFSFGYLKQAISTLLRRFAKYRQEQQIHHHHAMTARQRRRNKGRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7Z5</accession>
    <name>K1V7Z5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7Z5"/>
    <dbReference type="HOGENOM" id="CLU_547669_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7Z5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="498" mass="56660" checksum="68F150BEB67F2819" modified="2012-11-28" version="1">MQEHQIVGEAAFPLWCGTARGRHDFILPLRIGTSQNFTIIHHSAMPSSSHEPDAPRSHSPSHSHSRSLSGISHSFRPPSPERRPNTQFPYGEFSFELERFHAQSDHRMSFRTVEIEECSSVTSAGKLVPAFITELRYLRFERGVAIPRFMKRHEFRQAVDNLWKYHRKMFLTTDSIEKEYEYELTSPLNAHIAEDVVEQLLARRENAKQLSGNWNGTPDEIAAMLNGYIPPPAPGVGNDDFALHLAAFLLEHGPPMLPHDLVYLGIYEDSNFMDECGGSVDEHGGASHFTWGCLTKAHLGPRRWTGFGLEEPEVFLVPLDGIVEHISYSGGRLSSADMRWAVQMIRGAFGQAFPIFEGLRSLNGAQPGMIDIEKQAAIIRQYVRKLRGLQREFIPGKWLTEGAILHTHRYLFIQAEARLTPPYWSPWAGHLFEDPRADPFDQADMMDGDRLSEYAFHLVSYLHRHGLPSPPHELEVAMTNVRKWDERKAASWTVPLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V963</accession>
    <name>K1V963_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V963"/>
    <dbReference type="FunCoup" id="K1V963">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V963"/>
    <dbReference type="eggNOG" id="KOG2967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034384_1_1_1"/>
    <dbReference type="InParanoid" id="K1V963"/>
    <dbReference type="OMA" id="FKKNDGW"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="111"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="405" mass="44870" checksum="705513FB888F48A8" modified="2012-11-28" version="1">MADDNSDAPAPASEASAVTESPTTDVPVAESSAGPSSVASSSTTPLGPDGQPLSKKAQKRMAKRAYYEATRLEKRAEERQRRKERNAYLKAGYEAGTLSPKEREIMENKLQLKRARRHKPEPYPGAIVIDLKFDELMLDAELRSMASQIQYVYSDTRAAARPFSSVLFTGFSPESTPRLWAQMLKHQWTKWDGLHFRAEDIDAVQADLAALSVEGDDKEPAEKQEKECNEEDRTTFLCGSDLPPGFSKGRQLVYLSADSEEELETLSPEEIYIIGGIVDHNRHKMLCQNKAEKMGIRTARLPIGKYIENLPTRKVLTVNQYNTLGDWAKAFEAVIPQRKYTEKKKERREKREAAMKEGAAGSADVSQSEGGEGMDLDAVDEEAAMNANAEEAAMNAAAEEAAMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9D5</accession>
    <name>K1V9D5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase, class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9D5"/>
    <dbReference type="FunCoup" id="K1V9D5">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9D5"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="InParanoid" id="K1V9D5"/>
    <dbReference type="OMA" id="REGLNQH"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="498" mass="53087" checksum="80CCF42554C21B4B" modified="2012-11-28" version="1">MTADTIAATPAAPTTNGLKPSKPLGSDSKPAPTDEQNTHDVTDSSVLHRNLKVVLPIVTHARGSYLYTSSGQRILDGSGGAAVVSVGHGVPEIISAVSSQISTLPYVSSALFAIQPAEELARRMCRDSGMERAVFLSGGSEAVESAIKLARQYHVERGERQRTEFIAREASYHGNTLGDTWRGASSTSRYCRPTSTLSRRATAIATELEEKILALGPERVAAFFAEPVVGAAAGCVPFVPGYLCAMKRVCEKYGVLFCLDEIMCGAGRTGKLHAWMNDLVPSSLPARLGGEGEESEDAEGEGWGEEARPDIQTLGKGLCGGYAPLSAVLVSRKVCEGLEGGSGAFRNGYTFQSSGTGVAAGLAVYEYMEKHDFTMMMPVQLSEWLGAECARRGQYLRRLLEERVSPLPHVGNVRGLGLFQGIEFVADKNTKAPFAPGEHVADKVANAILEHGAAVYHGAATRITGDHIMLCPPYTVSEAEIDELVDAVVKGIQEVFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9Y2</accession>
    <name>K1V9Y2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9Y2"/>
    <dbReference type="FunCoup" id="K1V9Y2">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9Y2"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_1_0_1"/>
    <dbReference type="InParanoid" id="K1V9Y2"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="385" mass="42611" checksum="6FED08D583EF6213" modified="2012-11-28" version="1">MLVLRPATSAARTRLAAPLAARGLATVRSAPPKDETKPRTDEPVRQLPEVHSFLSRLFHDSDLIPLPMQKVLAPVIAKRRTPKIEEQYKEIGGGSPIRAWTEKQGEGMCALLDELNPESAPHKPYIAFRYAEPLTETALQQMQADGVRRAVAFTQYPQYSCSTTGSSLNELYRVAKKQGWGANGEVEWSTIDRWPADRGLVKAFANNIRHALDKFPDHERNDVVILFSAHSLPIEIVKPVHARSRRNSVRDYGGARFLKSSKVGPKAWQGPQTAKAIEGLAKQGQKNVLLVPVAFTSDHIETLYELDIEVKEDADKLGVRLERAESLNGSPIFIRALADIVSKHLKDYDSGKIAPASSQLLLRCPGCTNPRCGKTKEWLANAGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAB2</accession>
    <name>K1VAB2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAB2"/>
    <dbReference type="STRING" id="1220162.K1VAB2"/>
    <dbReference type="eggNOG" id="ENOG502QUID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043181_4_0_1"/>
    <dbReference type="InParanoid" id="K1VAB2"/>
    <dbReference type="OMA" id="HNNRLIC"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853649" description="Thaumatin-like protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="88"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="140"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="145"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26222" checksum="29B099C2AC5B906C" modified="2012-11-28" version="1">MYTSLLTILLAASFGSARTITVKNSCKDTIWPAMFTQDPSQAPKHPTGWVQKPGEVVSFAVPDVWKAARIWGRTHCNADGTGCKSGDCGDLECKAGVTGKPPSSLAEFTLQTTGGPDNYDVSLVDGFNLPVSIKPSRADCPAPKCVKDLNPGCPAELKPKDGGDGCLSQCQVDALAGHADNNPNCCSGIHDKPETCPKSGVKYYDYFKNGCHDAYAYAYDEKSESALWTCDGSKGLSDYTVEFCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAP6</accession>
    <name>K1VAP6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAP6"/>
    <dbReference type="HOGENOM" id="CLU_1327220_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAP6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="22996" checksum="C775C7DDFE707833" modified="2012-11-28" version="1">MTKETVLNQQSSSEMPSQLVGSIKRCTSASPEPSNKRAKLQEDDCHPPATASVDPVPKATLLGPTGPPTEDSWATDDKAWEENPSHKPTWIERFRTQPEAVHKDDGSRDSERKEQERESAEQQRAAWQEALKERDTEWKQTTITAWSGPSYCETCHPENFEQPLSDVDSGYEWSDGGGNDGQSYAVALQNPTSGIDSDQDSGRETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBE1</accession>
    <name>K1VBE1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBE1"/>
    <dbReference type="STRING" id="1220162.K1VBE1"/>
    <dbReference type="eggNOG" id="ENOG502S3WY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_1_0_1"/>
    <dbReference type="InParanoid" id="K1VBE1"/>
    <dbReference type="OMA" id="RTTFVWL"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="34860" checksum="26963B681E274551" modified="2012-11-28" version="1">MSYKILVGVYGDAISTLEFNPAAKSLKVVKESYVSPNPSWIAEGKGGLYSISEDEKGLVTRLELNGDAVKETSAKETGGGPAHVLVTSKGDVVVSNYVGGSVFWNDKLVPLPYAYQGKEAPNPERQNSSHAHHALEHDGRIFVCDLGSDKVWILEDGEIKDAVTLTPGSGPRHAVVHKLDGNVYSTPVPKPSSGGDKMLLPVNAVSYIPPCVEKHSHHAREMLGAELLFHNGALLASNRLMLHKPIKDRGDAIAVIPLGAKGELQQPSWIRTNACCIRGLSVSPCGKYAAVGGQCNGLVEIYATGEKWEKVAHASVRTPVAFLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBY5</accession>
    <name>K1VBY5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBY5"/>
    <dbReference type="HOGENOM" id="CLU_522946_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBY5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="521" mass="57611" checksum="55A1BF8BC119C32E" modified="2012-11-28" version="1">MKDEEDENNAVTALRKYMYRPPASTPSPTPSDSEEDLATSPVPRLLPSLVDDSGDEPMDVDEAPTPAASEPTFELWNVSDRKAAAMPPPPVPRAKSLPEPAPTLTTASSDKVPLARAPNAPSPPSPKRRLTLPASPPRHGLRRPLGPRTLSVNTIEVNADPNTAAKDADKPRKTKTVKPKPHRLRSRSFSTPTAKEAPPGTSFSKRFSLNLRFEGRRTQTLLHLVGQYLARTEQFAQLATLMLMSRTTVPQLRPLLHRTVHLTRTNLGPFLRTFVEVKMVDSRERDPRKRFKKKSPRRVTGIKCIILHSVPEYAPWPAALLEDVLTGAQRLVIRCPLPGPLMQRTIALLASPEQVCLDARAVDGPSALSFALSVLPLWNELKELTIHNAGALQGSRLLTALSNRNITTPGEYRSQLANMFEQRRVVYTLDFGEDELEPDGKSGLVVDHWDRLFGALNLVDAFSVNVVVPHIGRRTLPGPNGSNPVKHAMRAKRRGWVFGRIEDTKVRCACGQNVAKRVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD86</accession>
    <name>K1VD86_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD86"/>
    <dbReference type="STRING" id="1220162.K1VD86"/>
    <dbReference type="eggNOG" id="KOG2695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708204_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD86"/>
    <dbReference type="OMA" id="EHIFMSH"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="390" mass="42321" checksum="141F3B6ED297EFEC" modified="2012-11-28" version="1">MSNPGPAGPLGHLTGMYFDPDRNRYFPLAMRNLQLPLCPPATKRKRPVAAPSPPSKRTLRLPRRSHPHPSSASSSMSRGEHKLASATMQGAMEVAKCPGEGITSLKSYAGGLCVTTDHGEVILVDRSGERDWQALCSQPLLGVHFNPARSTVLAVANGNDPHAHSLRHTAYGALEAGTLDFPQRDLFAMSSFDDVTSLGSVRSVNVLTLGQTLGYARRRLPSDPLALHQASRDVLFAGLRSSAIVLEDLRVARQTSALATLPRGKAVTAVKRLADSAVPFGVLAAGLDHQLVLFDARFSRSPLRTFKGHVNVYHTNLAVTTSPDDMVVLAGGSDRRIRAWNTVTGEQILPANRHRRNVLGMDFRYNVKHVDVDENWNVRVASAGDVLRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDD4</accession>
    <name>K1VDD4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDD4"/>
    <dbReference type="STRING" id="1220162.K1VDD4"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1483013_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDD4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="182" mass="20207" checksum="D581544A51AC6C13" modified="2012-11-28" version="1">MTTPFGYRPSTAYKAPDSIELLDGAPVKSERIPDEASVFYAEDKQLRTDTSVGTLPPTKKIKTEGGVQEVVCMKLKRFPPGDNTGTQGFEVKHLRYQKSGAAKIINFSIVTLTSKVIRLAAARTATVEEMKSLIQYKEGTPLCQQRLIYKGLELPDGMPIGHYIHDNDTEARVHLVLRLRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDG2</accession>
    <name>K1VDG2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDG2"/>
    <dbReference type="HOGENOM" id="CLU_657537_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDG2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="46992" checksum="3E363EEDBAC7BB6F" modified="2012-11-28" version="1">MPDSPAHTTDETSRPGWGYLLREGKRHTREHARPNSSSRRRLVTHPACPLPRRMATEATGTARIRFVLDLVMSAKVLVRHDQLLLVCPDEAPLFTPAPTTSSSFGESAQRLSDSPLVEPRGHRLGVGLSAIPHPYPVPDDDTSAYPGCETVDGKCPVPGCDWAETENVQEHIQKCWTRYLRAEVVTVFGHTHELPNGACPWNLCGEEFPDPADLAQHLMSHSWSFESRCLMVREDGDICCLKFRDYSRHLEVFHGLIAADQDSTCSVTYCPVCYKFFQGQAKAERHLQSHLHALEQAFQRDPLCFADSRELGKTRVCVFHFADRSAPATERLKFFDEGAAHVVTHLLEMDGRYEHACIFELCDVQLKPIDMIDHLIEGHALTLTPFDRRPIEGDLSLLDMTQDTANKLKAGEFPITKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDJ6</accession>
    <name>K1VDJ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000301">
        <property type="protein sequence ID" value="EKD02055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDJ6"/>
    <dbReference type="eggNOG" id="ENOG502S9HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050866_1_1_1"/>
    <dbReference type="InParanoid" id="K1VDJ6"/>
    <dbReference type="OMA" id="GTDQWCS"/>
    <dbReference type="OrthoDB" id="9970474at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="268" mass="29299" checksum="6198A989A0120865" modified="2012-11-28" version="1">MSTDNAAITSAPAPWACRATVYSAVFWVSASQASSPSFNEAAYAPLEKDAPFATDSGKPEGGLATVMLVRYKDTPVGSYDEMMLLPGKFGFEVDSNGRRVKKSKLRITRIYVSQRNTTWNGRTNGSADCKVYPLAEPSETPVFQTRFQPMRYVPAMPMSTRAYGWLGIDLEIAQPPLPAGPSEATEAMLAAAREHGDAKSELAGTDKWCSSTPYQYSSATKLGWMDLRQADGGNFIPGAGRWAMAIKMTDTDLRLGESTWWDPPRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDW0</accession>
    <name>K1VDW0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDW0"/>
    <dbReference type="HOGENOM" id="CLU_2098550_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDW0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853717" evidence="1">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="140" mass="14958" checksum="889AB43567714F56" modified="2012-11-28" version="1">MWTPLALLALVAPALAVPCGKNFTITSANKGDACLGATYDSGFATVSKCNGSPGQTWMWDGLKIYNYVGPANNRACLTFSPFNTQTWITGQVGLQGCTDPTAGKRNQWMVNSQQQLVLDTKVEGEKVDPEGHLSSCTLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDX5</accession>
    <name>K1VDX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDX5"/>
    <dbReference type="HOGENOM" id="CLU_1397224_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDX5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853718" evidence="1">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="195" mass="20401" checksum="652CC7760F04F192" modified="2012-11-28" version="1">MKLFAVLPLLAAAVSAQFVNLNARGDVNVKTIDNKVTSKGLCSGNAQGEFSYSPETEKEKLTFKIELVSKENPVKLVAHYKNEATGEHTEATIDSANPSNTVGGEAVKGQKVVVTVKPEGASNDACEYSVSLDAKAEAQPTPSATQECPTYSVSPTTVVETATSTVTVPGAQPTGEVCLCDCDVEGAKPLPKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE77</accession>
    <name>K1VE77_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE77"/>
    <dbReference type="FunCoup" id="K1VE77">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VE77"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_1_1"/>
    <dbReference type="InParanoid" id="K1VE77"/>
    <dbReference type="OMA" id="RYSWQTA"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="37"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="300" mass="32483" checksum="39720709792148CB" modified="2012-11-28" version="1">MTDPVNLEPIPALQDSYVFHSQLPPEAAPGSDANKGGWIMGIDEAGRGPVLGPMVYACAFCPMSFKPTLEGLGFDVRQSLWEAFDVHPELCYSSSTLAPQAISAAMLRKVPINLNQQAQDATMGLIRAALDRGINVQECFVDALGPSQVWQDKLSAEFPTIKFLVCPKADSLFKIVGAASIVAKVTRDRYIEGWVDAEGPMPGSAGAGDEEAEELIRGSGYPSDPKTQAFLRQQLDPVFGYRGMVRFSWATVKVLLEKQGHSCQWADDVSQPSAAAYFTGEDKGRPKLWRDLGVSGVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF39</accession>
    <name>K1VF39_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF39"/>
    <dbReference type="HOGENOM" id="CLU_091101_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF39"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="267" mass="29516" checksum="F7BADE6B4607617A" modified="2012-11-28" version="1">MEEEFGQKLPRNSDNIPTIWWSRSSSTDSVITISVLAFLRYTVVCYDPASSLLDSSGTVFLMCPGASSCRGPTLAAHTIHQSRFNVGWATPWPTTPTEFNPAIVNARVELRILNFGIGSSRFSALNMCFETALPMVMALRDPLGAHGLCLDFAGELTLHLPEQYTFNGVENIERPLLNAELGLELDVRQGKLRVGKNCLNALAVDIDGWDDGQFERHVGDDFVAAEALLSLGVDGVEDSLSWLVSALHVARHWKPAFYLQDLWPRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFC7</accession>
    <name>K1VFC7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFC7"/>
    <dbReference type="HOGENOM" id="CLU_1391118_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFC7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="196" mass="21512" checksum="A5384FA7B51E75B0" modified="2012-11-28" version="1">MVAPPASNEREYKASARADGGWVRGRIVRRKREDSLRKTTSLRDQYGHTKEGAVLKTLRFSKLVDAPPSEHLGCIDVYLEAGTAYLSNKPRGAVNGNTPTAAVDEKMKKYATRDSILAQNSIADHHRAISRANSSKEHKPINPRHKRSTVEVAAPAEGSRKKARSTNMDTKPRVIDLSNAGNPSTVISLLDSDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG49</accession>
    <name>K1VG49_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG49"/>
    <dbReference type="HOGENOM" id="CLU_1504504_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG49"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="179" mass="19488" checksum="D9753A17B97010B5" modified="2012-11-28" version="1">MQEAAAEKARKKAEEKAETEHDKMIATIIIGTLCGVAFTAICLLCVCLNWSNWWDHIQRFFAGLACGCRRRRARTDCEQGPDATPAIDKEGTAPHFVARACGQNELALDHPSRASIAPSHDSDATAVADAQASAHVAAQPTVAQDHHASDYDEKNTRPEQDAKKAKDESTHATVDSYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGF1</accession>
    <name>K1VGF1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EFM4</name>
        <name evidence="9" type="ORF">A1Q2_02609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGF1"/>
    <dbReference type="STRING" id="1220162.K1VGF1"/>
    <dbReference type="eggNOG" id="KOG1271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515997_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGF1"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="7">
        <location>
            <begin position="300"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="554" mass="59651" checksum="ACDB6360EBC01895" modified="2012-11-28" version="1">MSDDEELPPSKLGTKEHWDMVYDCRADEQDIGDEGEVWFGEDSVHKMRAWAHDNLPSTSDKPLRILECGSGNGTLLLSFLTTPDPDAEPQQYHLTGIDYSEGAVKLGESVEKARRVAIEEGDEDVIDIDDVVNECTCEWRVGDLLRDEYQETWDLVMDKGTFDALALSDEPIAEKGGRLPSQVYPEQVAKLVSPGGFFLITSCNFTEEEVIKRYTKPGVGLSFHVPHKSFSFGGKKGQTVCTVAFTRDKAVANGNGHATPVAQPVQPDDPLFLCVDTDVCILTKSGKSGRAIGSTGNMTEDQKVMTELLTPFFGGEVKVHNDALLLGGGLLKHNVPWGVAVIAGTGSIAVGVEVDAQGEVVQAARRGGYGYLLGDDGSAYDVSRCAIRAAVDAFDAGEPDGPLSARISKHFGIQSVNGALSEVHKLNLSADPIQATNEQKLRISDLSPAVIECYTSTPPDPVAVTAVRAACRPLADSIVQLARQLLARPLPDGSQRTLQNAVFTCCGGVVRQEAYRRCLLEMVKEEGIEFGSIEPVSDVARSGAEGLVARSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGP7</accession>
    <name>K1VGP7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette (ABC) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGP7"/>
    <dbReference type="STRING" id="1220162.K1VGP7"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_1"/>
    <dbReference type="InParanoid" id="K1VGP7"/>
    <dbReference type="OMA" id="AGRIMWH"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119">
        <property type="entry name" value="ABC TRANSPORT PROTEIN ATP-BINDING COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119:SF1">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="33470" checksum="40AE4FE214919DEE" modified="2012-11-28" version="1">MTLLEVKNLTLRRDDGKGTAILNDISLDLHDGEVLILCGESGCGKTTLLKCISELNVYQKGRIALHGKTASEYGYPYYRTLVQYIPQRTSILAGTPLDFLKTCQGYASRKKRVKEISNDRPSLDPMDIAEEWGIQKFLWNRDWGTLSGGEAQRIALAIGIGLGGADIILLDEPTSALDAETMRKVEKTLVGLLPPNVRGGDGEAHYPRHSLGPKAIIWITHTPEQAKRCGTREYNMTPHVRHFDTHEEADRECERVHEGLEERAEREERERREKRDREERERKANGDAKPGKDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH32</accession>
    <name>K1VH32_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000249">
        <property type="protein sequence ID" value="EKD03430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH32"/>
    <dbReference type="FunCoup" id="K1VH32">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH32"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007860_2_0_1"/>
    <dbReference type="InParanoid" id="K1VH32"/>
    <dbReference type="OMA" id="YTHFKDD"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="751" mass="83496" checksum="933A8DD254F1C20F" modified="2012-11-28" version="1">MASGFISVLNIFFREIKPRGAWHIPKKGPVLFICAPHANQFLDPLLLFTEAWKAGRRTSILTAAKSMERKFIGFIARLFNSIPVSRAADYAKPGIGQVTLDKTDPLLVHGIGTKFTEQFEPRGTISLPKSVRFASAPIAEVVSDTELRLKSEFTIPSKDGNTNIKATNSVRSDLPADSEGWQFRVFPHVDQDQTYGAVFDALNKGGAIGIFPEGGSHDRTDFLPLKAGFSIMALGAMAANPDLDVKLVPVGLSYFHAHKFRSRAVVEFGEAISVDPKLVEMYKEGGAKKREACGKLLEQVHDALRAVTLRAPDWETLQAARRLYRVPGQQMSIGQVVQLSKYFMEGYLRFQDEPKIIELRKRMRKYNRLLRDMGIADHQVERASNRSVQSLVLLIYRLGLLIWWSTLALPGFILHVPVFILAKYISHVKAKEALKASTVKVQARDVLATWKVLVSLAVVPMVYLVWTIVGTTWCYRHDALPHLRRWIPLIVFLSGPGLGYASLKFGEAGMDVFKSLRPLFLSLWPGNQHEVKKLRKMREELSNEISELVDEFGPKMFDNFDKTRMLPSASTKKNQHVEPSMLSHPINWLDERIFGWRRNGSAAEAWADGTHDQNRSPRSVPSTAPGSPHESDLEDAEDVDYDDILAVIDHRGGKSPRRRTRAGRSYSDLRTQPLSPLATDGRATPSSPSPSSPLLTVPGEEDGLHHRRAYRANIDAHGEPIRPDTPDSNGNGVAGIAGIAGQGALGFDKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHE0</accession>
    <name>K1VHE0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHE0"/>
    <dbReference type="FunCoup" id="K1VHE0">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHE0"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007683_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHE0"/>
    <dbReference type="OMA" id="WEARHEK"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="182"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="600"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="744"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="917" mass="101355" checksum="8EB4ECE987C98B82" modified="2012-11-28" version="1">MGDATPLTLPDSLPYPITVVRVRVAAGTSVKRGDVLLEYKFLSATKRKQLETEERQGKRLSPQQWDGDMVGSWESSISGTVLKWEADIQPGRKIERRQATNRAPIPSKSMECAVSVVRMSPSEFQCAVRSSADASDDYMSAPADEAGPSRQGGYQMTHDASGVTVTTNEAKRLESISQKELLSTRRLSLIVDLDQTIIHTTVDPTVGEWLKECEEDAEEEKKAAASPNKENDGGTTGDTAADDGKMDVDGAGKEPQPESTTPPGSPKRKREKNPNAEALKDVAKFQLADDVPPGVSRRHQPEPVRWYYTKPRPGLNKFLEDMSKLYEMHVYTMGTRSYADAICKIVDPEGKYFAMSAKSLVRLFPHDQSMVVIIDDRSDVWGDSPNLVKVVPYDFFVGIGDINGGFLPPTKPAVTAMANILSPASSTASSPSPKTPSDIPSTEEGHDQQTKLFQEILENRPLAKLEEEQGFELDDEAANGEEKKENEEKSGEPEAETKGAGDEEKKEDGAAASGPAEGSEKPKEDGAPPPKSEEKAVSKHDEHHHRHRRQFLNVNDHELKRVEDILTEIHTDYYDAYDSRSPGSTKMPLQCDVPLLIGEIKDQVLSGCVIVFTGVIAINQKPQDSEIWQQAEAFGAQCQVELDERVTHCVIGSIGTEKMRRASRMPHVQVVWLAWLQTSIAFWRREPEEPFRPQLPRLERPDTPPKPEDKVPDAMQIDPEDIEKDAEDFKAAWDDAAQAELDELINGDDDDDWSSSDGEDDEDKKNDRKRAASRSPEPHRWSRENTPSRSILSRGPSPGPPKHVRYADDENQPLEDVREPQPGDIPSYPPKKKQKVLMLDAPSDDDDIPEANRMVYKPRPGDGLTGTHEDGVEKADGSQADGSDGPDPTSSDTETDEFARMLQAELAGEGSGDEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHT0</accession>
    <name>K1VHT0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHT0"/>
    <dbReference type="STRING" id="1220162.K1VHT0"/>
    <dbReference type="eggNOG" id="ENOG502S6S8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_600186_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHT0"/>
    <dbReference type="OMA" id="WEEENTS"/>
    <dbReference type="OrthoDB" id="2524554at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="499" mass="54358" checksum="6517A6A41AF2CDDC" modified="2012-11-28" version="1">MSRLVRLSRPLARAPRRAYSDLSHTTLPKMPPTMPREDYASPTMYAFNMLGKTVKYIVIGGAGLAALSFAGWEAAHLYIEHQMPSAKSKPGSHGWEEENTSWTGEDGGTTSKLSWKARMALRAAWLCWEKGAGVPGAISTRQSIHPQLSGAIGGLNKIDRGYELAEQYIDVAIKDAEKRGMVFPPHEGADPVALDLVTLKASILERMGTPDTLEQARELYEDVARTPKPQTELNQALSIRLALKLSDLANRAGDSADAAKWRQWGLQTAGVQIPEPPKSSWWSKPKPEPVTVPELGAPVRRATVALLLSDSALAAQSGDLDYAAREHEVIRAMVPTPERLVTPNNTNAPEVLHSVWLAQRRALLDLYRGSVAHAQDRKSTAPLATIALAAEESDAVIAALEPLPAAYKGPLLVPAERLRREALQTGAEAHFTEGVLEEKQGTEPALLKALASFERAMSLAALESGSSDIRGEKEDEGVGRSPEWTRYARAYDRVKAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI47</accession>
    <name>K1VI47_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI47"/>
    <dbReference type="HOGENOM" id="CLU_858389_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI47"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="324" mass="35669" checksum="7122E4EB2DF22502" modified="2012-11-28" version="1">MLPRRHTKPQAKSHHGLRDTQRDISDVHGREIQGQGLGPPHPSHGALCARRRHLAAGHEGRAIDPRSPRAGRVSPHGRRVRHAHCATKGSPRTQIADSAERLGVAERLQSYYAARDWAILQQGAAHAAESIVAGTRGLQCMRLDSETDAETAASRRDGRGDAVLAVRRHAPDHGWAELVTFSARDAAAVRAALRTMETRLPMEWHESCAEDAADCEDGCGAGKVCPEEEVEERGVHFVARLEWPTSLIEQERIDQGSDEGRIRLVGKEEGEHAEDKRKEIVRGMKLLMRGSDGLEINYQVEDGEITVTPPWVLERHSGGHPALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIA1</accession>
    <name>K1VIA1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_06842</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIA1"/>
    <dbReference type="STRING" id="1220162.K1VIA1"/>
    <dbReference type="eggNOG" id="KOG2721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044271_1_0_1"/>
    <dbReference type="InParanoid" id="K1VIA1"/>
    <dbReference type="OMA" id="PRIRSSW"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="14">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="15">
        <location>
            <begin position="167"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC98871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="331" mass="37096" checksum="668726D7C783937C" modified="2012-11-28" version="1">MGAGSTSESSCLPCLPRSLPFAVVTNSPPDIPSLSPKSLQTPSPRLLLESPWRLTINPLDCTSTSTSSCPSVSSEADDRFSDVQEFEKPNDRRALDLMNRAAKAVMDEFEEVVLGFGESDEFSKINSAICSVFTSAYVFYWPEYFPNDRLRYPPTFDSRVVLYPGEKEIRDYFAWRQADTHINNLYNTCFWALVKAGRTPREANKELQGTNSKDKNEMLFSEFGINYNDIDPFYRKGSVLVRIDPSSLPKAKCGVATATADADSDAPSTPADTEGGEGEAELSVEEARRQRKLEKKAKKAEKYEGMTGPVVYLNDDIIKDAFWNERPWLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIH9</accession>
    <name>K1VIH9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01774</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIH9"/>
    <dbReference type="STRING" id="1220162.K1VIH9"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494480_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIH9"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="15">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD03950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="607" mass="65331" checksum="5BD50562BDAF5052" modified="2012-11-28" version="1">MSDPRKLKRWRASVTNEVPLTGVIPPRQQPEALGGTMDPPPKRAQAETPCIYNSFTFTTPKRLTMAANEEQSTSLFSTLSSFFLPTAYAEEEQKEEAAEDTPAEEPEQESADDEEEEEEEEEEDPEDAPPIREKCEQTECQAAAKHFQACQQKVEAGQGWEGEDCVEEMFHMMHCVDTFACLASARVTMSSQELILSSSAAAGASIPATRTQTTPAIQLHDLATSSHVQAFKTITCAPNTLTWCQSHDSLGATPEASSPGKVVVRRPVAEWRLACCRIPEWPDLSLGASGLMLASWNAHYRSVTTLSFTSDSALLLSSSADASVHIFLVSRLIDCDASSPVGKPYGSLSDHTLGVSAVAIDVVPSGSFRPPGDFCPASLRLDKLSRVDSAERFVYVGSKQGDVYLIPLYNRPSQTGLVEAVNGHGPAAPPVKIENACISVGTPITCLALSFSASQLLIGTSAGDIHVHALPSHQQVRSIPAHAGPVSYLSTVSSPPDLVGRAGGAGDWPIMEIKNLERMRVTKSARESQEVSILAQPEARERLSLLRGAAGLERASAMATVGESVREDDTAALREEIRRLQGALDKAARINEKMWNGVVDLKLGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIU6</accession>
    <name>K1VIU6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000336">
        <property type="protein sequence ID" value="EKD00661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIU6"/>
    <dbReference type="FunCoup" id="K1VIU6">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="InParanoid" id="K1VIU6"/>
    <dbReference type="OMA" id="NALPCDT"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28028" checksum="6E8557669384ECDB" modified="2012-11-28" version="1">MVHEPTRKRILLVRHAQAEHNVASDWEIPDAPLTKVGRRQAGNLHAATRTGLQATAELLVTSPMRRALETTLVGLPNLKERLEAQGKPTIVLDLAQEVGDEPCDVPLHPVEALAASNDGMFQRAGLDFSTLSPDYASKKGIFDPDNTEERARQLRQWLRARPEREIVLVAHGDILRYLVDGYHSSRRWEHCAVLLTTFETNEHDWDARLVEVGPRGIVEPTRRPNHVFWSDIVERIATPTIEAPKILSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJE0</accession>
    <name>K1VJE0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJE0"/>
    <dbReference type="FunCoup" id="K1VJE0">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJE0"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJE0"/>
    <dbReference type="OMA" id="WHIRIAL"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30636" checksum="405ED75891810D7D" modified="2012-11-28" version="1">MALKILTRKDVDKVLDALDLQAAVDSQAAVFEAYSGPKTTDGKMAAVDRKTAIKIVSVPTSGGDGLPGTTLIMDELLGNGKPTNIVLFGSGAQAEAHARMFLGLYPSITKCTVVNRRPTERAAHLVDALVKAFPKVEVCLGITSENDFKLSETVKDADIICTMTSSTQALFASKDVKPGAHMCLIGSYKKHMREVEDDLVKRAGIVLVDSKEACEAEAGELHNLTEDQMVEIGKIVKDKSKADPIKQAGDVTMFKSVGLGVQDVAIAQTVLDQAEKLGLGSVIEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJF3</accession>
    <name>K1VJF3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJF3"/>
    <dbReference type="STRING" id="1220162.K1VJF3"/>
    <dbReference type="eggNOG" id="KOG0278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_772051_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJF3"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="359" mass="38402" checksum="0E0E5ACB1594F595" modified="2012-11-28" version="1">MVGFSNGLGNPGLGGGQGALGGQQTPSNGNQQIKVQPLLCAGHTRPVVHLQFSNILPDGTYLMISACKDGNPMLRSWLGDWIGTFLGHKGAVWSSKISLDTSRAVTGSADFSAKIWDTNTGEALHSFSHNHIVRSVALNPQAQPQYLLTGGNEKKIRLFDLNRTDAQPLVLGSNPDGLSCEGVIRSIVWDEGQGGAVGVSAAEDGKVRWWDLRTLGQVGEVDLGEPVSSMELAHGGGTLSVAAGKNVHFLDVMRQHPPVSIKLPQRGHVGVSAPLPTRPLRRRFRRGPLGARLRPGLGQGARGVQGPPRSRALRVLLSRRRGLRLWKRGWHDQAVADAAWQVLRTLADSGLGACDAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJH8</accession>
    <name>K1VJH8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJH8"/>
    <dbReference type="STRING" id="1220162.K1VJH8"/>
    <dbReference type="HOGENOM" id="CLU_2672867_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJH8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="75" mass="8047" checksum="2438E58D937C8235" modified="2012-11-28" version="1">MFKKALAHQSNATPIRSSARRQLLQSIYEQYPALKAGCVAEGENGVTEKELGKLLLPDSVRSATFETSGGVEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJQ5</accession>
    <name>K1VJQ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJQ5"/>
    <dbReference type="STRING" id="1220162.K1VJQ5"/>
    <dbReference type="HOGENOM" id="CLU_323709_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJQ5"/>
    <dbReference type="OMA" id="GNPGVHP"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="893" mass="98090" checksum="A7DA8D434727334F" modified="2012-11-28" version="1">MSVQEAQHVAILDDMALDLVYEVFTESSAPYGFKRIIKLDKGGAPSLDRLRLAAEDVRENVDLFRKELRRIFNDYLDDKIRVNPEIRQWLLEAWISTAYGPYTKIRPNEKGSVDLVTATTLARGKLERIVGVEDVCLNLKGDGNVERLGFDEDFLDYSHRDIPKATVGPIRLVKACANTKWLARPSNPGVFFPDGADVQWLVLKRTIPEGEMLWWAWGDGEYEKEWLVIRLPANTDVHSPCPPAEKRKSRGGSIASFVVPDWEPPIPSPTQAEPEEKKPKKRVRTYSGSKRTIKKPRRPSSDHQASSPSAPRSSSTGSLSPPPPVRRRLPSETPEPSPIPEQSSESPWVETPAADEEGTDLVMEQTQVDVNGMGNRQDESYDTTMQPVADDDKAEERMDQPSSVSERSRQSSVSDLTTVLQTASSPMSAAKVSPKAVHNDGRQPKPTLVRMTTEPTFAAEPSSAGAVSSELTPVAQLAPAVQLAPPLADAPLAPASDGHVEHPANMQSVVQNLIQNVVPGTVPAQLLSAGHTSEETTILNLRLVVSSETLRNAAPATDPALEERVAALEADLDEQKSRNDALQQENASLKESVQQHNAVVSQHQADMSDVQSENASLQVQKDALEHDKAKLLKEIDGFKKQIAKSNQDTKKLEKDAKQAQGNYKEAQQDIKTIRREKDEVEKRCQILAEEIEKLCRDKEKLSEDLRGFVMRRKMAAAGPEERVPREYPPPPPPGEYPPHPHQHPHPPPPMEYPYPPPGYPSPPPHAGSPWSPPAPPQWGPSSAGPSPAPHLPPHYPPRPATASGAFPHGPYPDRPPSGHGHGPPPMHSPDVRMRHDRERDRLPPPPHPLDVKPSLPSLPAVLSGRPGGPPPPPPPHVARSVSGMASPNGKFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK85</accession>
    <name>K1VK85_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK85"/>
    <dbReference type="STRING" id="1220162.K1VK85"/>
    <dbReference type="eggNOG" id="KOG0140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_1"/>
    <dbReference type="InParanoid" id="K1VK85"/>
    <dbReference type="OMA" id="NYDKMGV"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="266"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="46508" checksum="2ED61B60101050F2" modified="2012-11-28" version="1">MLVKSGLVRNAFRLPRAATAHGRTAQRAYSTPADAKGINFALSDEQAAIHELAQNFSREKIVPVAAEYDRTMEYPWPILKEAHELGLMNTHVPESCGGPGLGVLDEVLIQESIAFGCSGIGTAIAANGLGQTPVIIAGSDALKKKYLGRMTEECMVASYAVTEPGAGSDVAAIKTKAEKQGDKWVINGTKMWITNSGHANWFFVLAVTDPSAPVNKRMTGFVVEADTPGVAPGKKEINMGQRCSDTRMVNFQDVVVSEENIVGKPGEGFKIAMGVFDVSRPVVAAGAVGLAQRALEEATKYAQERQTMGKPIINHQGVGFMLADMALNVEASRGLTWRGAWVRDQGERNSVYPDEEQELTWVAYVASLAKLMASKAAVENASLGIQGIGFNTETPMEKLFRDSKIFELYEGTSQIQRLIISRHLPTMYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKM4</accession>
    <name>K1VKM4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKM4"/>
    <dbReference type="HOGENOM" id="CLU_1235808_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKM4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045702">
        <property type="entry name" value="DUF6060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19535">
        <property type="entry name" value="DUF6060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="224" mass="23705" checksum="C6723F3E4E6CDC88" modified="2012-11-28" version="1">MPAVGVVVLRRHTLPSEVNGMILKKRERTPWTPHHKSSLQDPATDIDPSMLSLVLFANLAAAVPLPQSETQSVAGTTPYQGTCKSFEWDPKPTWEDGHLGSIPVSKRMDCRQSAQPCSINHADEDTKRPTEWSSSAKLSDEGKAAVDKAVGGGELPPKPAGGGFEGASYSLSVDPGQIGYLSYNPAAVVVHGIFKGCEDGKDHDGTILFPTGKGSFGIVTVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLG0</accession>
    <name>K1VLG0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000348">
        <property type="protein sequence ID" value="EKD00117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLG0"/>
    <dbReference type="HOGENOM" id="CLU_1846507_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLG0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="139" mass="15999" checksum="1732F6DD0435BC84" modified="2012-11-28" version="1">MVFGFGSNDPAKIAWQNLEQATARGISSIDKREAAAKIFHQKGHVHGALMLALYYRATIPSRDYEAEEAYKAWQEMLDRCEKYGRAKVDPFGFEVKGKENWYIFQRNQAAECRESSHAADQEYVKAFVEDWKHKHGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLH6</accession>
    <name>K1VLH6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000159">
        <property type="protein sequence ID" value="EKD05030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLH6"/>
    <dbReference type="STRING" id="1220162.K1VLH6"/>
    <dbReference type="HOGENOM" id="CLU_714081_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLH6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="387" mass="43888" checksum="FD1AD850D41435D4" modified="2012-11-28" version="1">MPRGWSAVLKERYKHIDPKTVKPWDLLVPAGLPPTVVPAATTTQSLQFHSEEAKEWYEATVRLNQSQPYATPEFSDDLYPGQEVWKDGKSTKCPYPGCKKRNVAGPAPRAEHVHSHHRDDRFDRLYDLFGKTHKLTTCPWDGCSYSILDGRDFARHLGQQHKRNRCSVVGKKGLCRVKTTPADLPRHLELYHGLLAAADDSNEILCYCHLCYHWIGGRQSISEHYDNHLPGVLENVARRPHLLGVTGVLHSGHICPKCLSDPSLPPEKRLLHHKVLAFHINDHIVDVPRQEKIGCWYPGCTARSKFKPLQLADHFYCAHSIDLMSMKKKDESGQSLSPRTHLISDDSSGSRLRLSAITRAKFNNRQSDFFRDKSTAELEESPESEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLI8</accession>
    <name>K1VLI8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLI8"/>
    <dbReference type="eggNOG" id="ENOG502S1K0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046576_1_0_1"/>
    <dbReference type="InParanoid" id="K1VLI8"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="415" mass="45235" checksum="6B64279EFAF7232E" modified="2012-11-28" version="1">MFPPQTILWSFLPPTLHPPNQSAPDAPQDEGSREHPQRCSARAPGLAQAAIFTRRDDAHGDGFGCESAKTKKRARDDDLLRPLPQGDEIRAPESLSFEEITDPEVCCRLRTVRADTLGFASNHGDGKSSACEVRVDVHVHISSLKHALFLGNVLNAQQVKEAEDEIRELPGEHDFKAKVTTKDWKRGKPQPAVGSSQPWVGIMNSNPVIERPDGTWRAIQQGAAVEPSVVSYVLEIANSQAYLYITRALKTFAPHVLGAMQLVAESYEPQELDRVGLHLYFKPDVTGWGQRGTLSVAKILETMKDKVADAETGAEPDADEKVEKADASAPGTKTEGDEQTDGAVRRSKRLKIGQEEDPNAKGVEIAKDTGPADKDGKSKAPSSDQPGTQKPGMTVEEYEAMLDAEAADWDFPDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLK2</accession>
    <name>K1VLK2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLK2"/>
    <dbReference type="STRING" id="1220162.K1VLK2"/>
    <dbReference type="eggNOG" id="ENOG502SA6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288233_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLK2"/>
    <dbReference type="OMA" id="HGFLTQT"/>
    <dbReference type="OrthoDB" id="2575475at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="2">
        <location>
            <begin position="778"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116063" checksum="839A1AD66E8C3096" modified="2012-11-28" version="1">MTTPLDSPESLPVVKKRTYGRIAVERDRQQENSLLFADLDPSPDTANTYPRHTGDDTVGWRQRVAELDAASNEETTEESLADALRQLRKIGPHPQSPSETSNLTSLSTTAPTSTPATGHERTKLTLEESLNVNQDPGGRGTVGRLLGPRGSCLSENEPAAQHTTLHLFDEDDTLGMATQKGGPKALSKADRHQMHKDIAQAERAWLKNASVAIEPSSSPGRGPESDDIQQFTPSSAAKHDGQQASCGPIIPASSSPSKSSPTLQSKRAPGKFPKFGMLDDDLEELTLDGVLAATSKRKSLNARKKAALEQQRESSRRAIAEDDPLDVVLSTPEPNASGKERQAPNALAIFNRTSAVSAPSRRQQHFSKMSGKHKPKKSLTETHAEYAAQEFGHANLKRRNAGSRPAGQKQGRDEPVQQTQVNDNLLRHHQEQANKLSKEKEARYGAARQLPPKEPLAAVHLLPALDSQPADGSDSDDDYVDQQQSVASSSEHEDDGDSADQHGDTTIIGETIDVLSPLVVEGDRHTEDDEGDDELATLRLRKSRTRAPRRVAFESEDEEDGVDHAQTQKPVGDKPPSTKEPPGSLDLAGFGSVDGGFSQLFGETQPPQSRFQVSAVSPEALTSKSDDAFAGLRHQEAGLLPAEALLPSVSISESQALRDKALIAGETEAGAEAGKEPDEGQRYLNSQGSPSMEDAAPRSSVSIENAPHEPASVLPSSTVLNSSSHFETSPTQANFARLRRRGLASAESPGDAGNLSMVKAKEVNAFDVLDAGALAESRKGRVNFVDEQAEESDEDNGWFFPQKDEGDDEEDSGDEGYIKELVDDAALTAEEKSRLAMQAAEKHREITREDDARIEAEAKKMTEGYYRRKRHGNEFMSDEDDEGGKTRKFNKKQRRQRRLDREDGLYKIGGEENKFLEAYEAGLESDVDFEETPASPTGPTSPTNQRLTAHERIEMLRDRGRANRTEEEDEATSRAFAISRRRRGHTSMGGSESREDLRKFLADEASNPKRSGGGVSVVQRSNVATATNPASTSHPGSTVNKPRGSSREARRLGSSNSVLMDRAERFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLN4</accession>
    <name>K1VLN4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLN4"/>
    <dbReference type="STRING" id="1220162.K1VLN4"/>
    <dbReference type="eggNOG" id="ENOG502SBCZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1422354_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLN4"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="191" mass="21176" checksum="356260E3D7223D19" modified="2012-11-28" version="1">MQGLTEQPNYAENGGGAPPRTPAPAETPEDAERWAAQLASTKPFSLEPWDVMLDRERPKVDVLLTPSCNDLCLRTPRTLLRPVRFGDSVAIKKIKTEPIVQKTQLYGTPKSLQEIKANFQTRYIASCIPAISRDEYAPEGEEAQGGAWRDEYIWAITVKPGKTAEVKILPPGEVRLQNRLTNLDGYVGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM62</accession>
    <name>K1VM62_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM62"/>
    <dbReference type="STRING" id="1220162.K1VM62"/>
    <dbReference type="eggNOG" id="ENOG502SCD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077169_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM62"/>
    <dbReference type="OMA" id="NATHFSD"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="243" mass="26399" checksum="63993690DF14AFC7" modified="2012-11-28" version="1">MQGPKTVTALSLLSMDPSPTVAASAQQAARTKHGLVNVTRLVRALERMDQEEEDMSWLEVQKTWETVLELATFPLSADSRASTTAATLDDLERILARVEVQVQDSARLPTPPEEAAAEDLLEAHVPTKLEDEPVELEIPVAAPSAAPAVVVTPTASKAFDMADYFARREQESKQGGDAGLLPLKSKVAKDPMDEEGMRQRLLAGANSKGMGARELQEELSGQLAGQQPREREEPAYLPFLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM80</accession>
    <name>K1VM80_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM80"/>
    <dbReference type="HOGENOM" id="CLU_1058407_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM80"/>
    <dbReference type="OrthoDB" id="10266817at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="263" mass="28601" checksum="57236CAB75EB8B3C" modified="2012-11-28" version="1">MTLRSLARPMGRGARSLLSARVAPSVSARFSLDRAAPATVRIGGRSYATQADPPPSSPAGTPMMIGAQLRTQIESELNNMRERVLKSKPGVWLRPLTQEETELVNMGQVPGFENAEVMALLDLQLREAPFFKDRQRAGSDGMGIHVPLLAHLGSTEPEVPCYPFKLLFGQQAPRAITAVRDVIAAQRKRVTEAAEHSTKEVTEQTEKFRHLDDAPLVAVLVPNGGENRDMGMPLAISLFRLAMHEGNGHEEGFQTGGDGTKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VME7</accession>
    <name>K1VME7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000110">
        <property type="protein sequence ID" value="EKD05350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VME7"/>
    <dbReference type="FunCoup" id="K1VME7">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VME7"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_0_3_1"/>
    <dbReference type="InParanoid" id="K1VME7"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="284" mass="31294" checksum="0617649250AD173D" modified="2012-11-28" version="1">MGGDTTVKRRETKVPLKRPAEPAPLTRTWKTVLYPISAVLHRLHAWLTTLLLALIALGPMPKHIGFVMDGNRRYARSRGQKVARGHKMGSDSLKRICLRLRIPVVSVYAFAIDNFNRPQEEVDALMSLARSSLQEICAKGGFLDQHGVRLRCIGRLDLLKPDMRAALLEMEAATAHNTRGVLNVCGPYASRDEITDAVRETVREVEERGENPDKARQAPVRLHDAAVPRRHAAALHQDVLAGLWAERSAPDPARVAAEGLAHAGVAGRGPEPSQEDESVSEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMU4</accession>
    <name>K1VMU4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMU4"/>
    <dbReference type="HOGENOM" id="CLU_1138693_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMU4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="244" mass="27187" checksum="B6182697B18898D3" modified="2012-11-28" version="1">MPPPQDRDNDEIGLDFHLVTVIMRQGYERSDGTVGIYDAATGLPLTFERHHPLKCSPAAHARHGQPFVLPAALNETGSDKSTSQRPNIATESWSMNKFRGSRRFAALVGVIKYMLPTLQQLRDDLLAHGLFKRHRQLKPISLSSPVAQLWADNKRHPLELALLDPGRAPRLRRDLEAAHSGRGHRGAVESCKQCALPREKVEQAERASVIISSCPHLHSLRYHSEAGSDLCFLQEEGRDSLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPL6</accession>
    <name>K1VPL6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPL6"/>
    <dbReference type="HOGENOM" id="CLU_2016824_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPL6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012587670" evidence="1">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="125" mass="13857" checksum="3159A741FE9EF264" modified="2012-11-28" version="1">MLFLIGSVLLSLVAAATPAPYCNVTASVEDNTLLRVHSCNYQWIVSAGNQPNCPETQVGDNFVYKCIILDSEELGNSCDETYFVAAARRELSCPVTADRAEFDYCDPIPEFGLQVYSCPWEPYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPQ6</accession>
    <name>K1VPQ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPQ6"/>
    <dbReference type="STRING" id="1220162.K1VPQ6"/>
    <dbReference type="eggNOG" id="KOG2435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752304_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPQ6"/>
    <dbReference type="OMA" id="ARIMRME"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="119"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="347" mass="37825" checksum="4713441820DD0B96" modified="2012-11-28" version="1">MSFAQRLNRSLDGLKRNTGKGMWNTASRPLTTSAVLRMNPDPHSGALPIFSFTADSPPVNEVGDFALGSDLDIGGQSTCVFTQVSDKGDNLGEIANTDSGSVAQLPSSAGSAADDTGPSGGAYSAQTQHEEKGKPSHASFHGILSLNVPAEHRGKIRTGYAAFRNRKRQTLMGEETWDLDRYTHLRVELAYRGWDVWRSRWVCNLQTDGPVRSDLFQHRLDLPSEYASKEPTPMSPLKCTGLNFTTVHLPLDGFVLTNSGQTSEKQIKMMQNKIRTIGFALLGGGRSAENEAPAALEAESEAPKNKYHKVGGGAPTSEGMPTDHQSEGYYELCIRKVDAVRWNPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPY2</accession>
    <name>K1VPY2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oxidoreductase/aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPY2"/>
    <dbReference type="STRING" id="1220162.K1VPY2"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="K1VPY2"/>
    <dbReference type="OMA" id="IYLYQVQ"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08274">
        <property type="entry name" value="MDR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="363" mass="38348" checksum="290D1B8AB46439A4" modified="2012-11-28" version="1">MPTPAVPNTMAAVHLTGHGGPDKLEYRTDVPVPSPRPGEVLIAVSAAGINNTDINTRLGWYSSSVTGSTAASASPSTSGGRDGDGSWSGKALTFPRIQGADVCGRIVAVGAGVSPSRVGQRVLVRTMMRHYVRDQPWGCWTFGSECDGGFAQFCVAPDDETFAVECDWSDSELAAIPCAYSTAENMLHRAHVRNGERVLVTGASGGVGLAAVQLAKRRGCEVLALCSPAKAEAVKRAGASRVLDRNEPLQGVEVDVAVDIVGGDGVQSLLSCLTRGGRYVVAGAIAGPMAQIDLRTVYLRDLSLFGATFQDDVVFENLVGYIERNEIRPLVSRTFPLQAIRQAQEIFQSKSLPGKLVLIPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQL3</accession>
    <name>K1VQL3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQL3"/>
    <dbReference type="FunCoup" id="K1VQL3">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQL3"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011072_5_0_1"/>
    <dbReference type="InParanoid" id="K1VQL3"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="153"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="703" mass="77910" checksum="0FC0EA8BAA5AA87A" modified="2012-11-28" version="1">MAPGRTKVTKSGLGKALINRKIKEAYTLDESNPLASVTHERDLDEFLANAALADADFTTERSKIRIIAGPGAKPEANPFLLSEAEEKKVARKQFDFRDGLKIPRRPAWTTDMTRLQLEKQERESFLDWRRELAHLAEDSSLLLTPFERNIQLWRQLWRVIERSHLVVQIVDARNPLGFRSADLEDYVKEVGSEDGDEAVPGKGKRRSLLLINKADLLTYDQRLAWAEYFEAEGIEYAFFSAANAAAALEQQEKQRKRALGIYESDEEGSDDDDEEVADSDEEEGSEEESEEDAEGEEPEQPTALDKGKQKATVEDVDEAAEALEQAQLEEKPEEIEDIRTRVLTIGELEDLFISSAPPLSDFATSRDPNPSKLMIGLVGYPNVGKSSTINALIGSKKVSVSATPGKTKHFQTLVLSDKITLCDCPGLVFPQFANTQADMICDGVLPIDQMREYSAPVDLVCRRIPREILEGTYGIRIDVKEIEDGGTGKVGWEDLLSAYAIARGMTRSSFGMPDTSRAARYVLKDYVNAKLLYGRAPPGMDADAYMSTSRQRTLQEIEDSYAAGRKRAPETHVSKNSDTYVAPASSKAAITSMEPIEEGPAPTHNQISKNSAVAAGRSGRVKAAALEDHFFSEPGAQPRVVVKGRSQGAAPEMDFSRPTLYPHQRRLGPDGMPILETGVKVRNNGKKHFKEKRGKQRSGRGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQQ0</accession>
    <name>K1VQQ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQQ0"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="K1VQQ0"/>
    <dbReference type="OMA" id="CFSTFTA"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38184" checksum="954BF6BCE110D2E2" modified="2012-11-28" version="1">MLKLTSSGWIGSMQYLLIFLPSVVMGRLVDQARFLPYFWTASLLYPFSIIITAEVTAFWQAILSHGILFGFSVGLLFCPAVAVTAQWFHRRRAFALGLVAVCSSLGGTVFPILVSRCMRLVGFKWTMRISGLLVLYCTLFASCVLRTRLPPKSAPGGVLNLRAFKMPYWSFWVASCFFIQAGLYTPLSFLDVMGKSLGLGDYSVYLISIANAGSLLGRIGPAYIADKWGSVNFLIPGLVCSMVTTFAWPYATSKGSLTAVAVINGIFQGCFVSLVAPAIGALGSVEDNGRRFGTCNTIMAFGSLLNAPVCGAILEATSFHQVSYYAGSMLGAGIVLMTISRSLFLKKFWGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQZ5</accession>
    <name>K1VQZ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQZ5"/>
    <dbReference type="STRING" id="1220162.K1VQZ5"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265659_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQZ5"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="190"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="404"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="795"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="893"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1160"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="725"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1169"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1252" mass="132939" checksum="72A6D3D62BE3266E" modified="2012-11-28" version="1">MSLPSPREHISFSSIADGPASSQNVAGGSHGHKPGPSTSMAAPQSSAMSATASASSASSVRRPSTTSATKGRPAHASSSYADPHAGPSSQPTSNHTSSTGLHSSNPPSASASKNNSFIGGVLSRRGSTRDRPERAEVSPAMTSSTRTAGGRSRADSSDGRRSPTESEVIETQTLNMERDPETGRKLINQYLVLDEIGHGTHGRVRLGRDMSVDASQDELENDLATGKGPFYAIKIVDRNGKKRLPPFGRRGREGAKLVAENEMRKEIAILKKLHHPNVVALKEIIDDPDSKQVYMILEYCQGGEVRWKQDNRPTLTIAETRKIFRDTLLGLEYLHHQGVIHRDIKPSNLLCSGDVVKISDFGCSHFSEALYAADGGGYVDDIELAKTAGSPAFFAPEMCYSEIPDEPTPTPGATSDQKVPTFTVRPPSTTQEDAPTATRGSSIYDPRLSVTRSQSTATIPNRQRRPITNAIDVWAFGVTLYCLLFGKTPFDAQNEYLLMQVIPTAEYEIPATMGKEQVPTSGPESTEEVREALDLLSRLLEKDAGQRITLDQAKRHPFALRGMKDPQGWLNRTSIHDQTCVTVTNEEVAAAVTRGNGIRDKLKRGLSKLSNRLGFHRNRSRSVTGSDNADQSAASSASETPNTRRVASGDSIPSTASGPSLGRRLSILHRNPSNRAATSASAPGSGDESSRPVGLIASQLGASQSADRSPSSTTQPVHSEEFLRQPSSQSVDNTPRQMRSIQSLEKLQSASTASNYGRRRSLVEPEMMLRSRSASNASSSAGSILGAIMGRTAQITKQRSLRGTGLSTMRSKSQHDYGSQDDHDNVFGSSIDSHATEGRSELLRGRSFDESARRQSLDTFESGSPSSRGSHGFHSPERLSGWDQRFLQDQGMPLRRGSNLSDRPVMEIDDEDLDWDVDVPDSDEEDSSSSDGLPKGHGLSSAPADWNLSHCLSDLDKQAARRTGPTSPTRASAGGAHSPVRTGTAQSLLRPGGGLDMNRLGRPPSSYSYRPRPSPLVNDTAAGVSSGESSPSGNRTTPNASSAPLLAASTNTAPSGGMEILNGQTTQKGQSNGNGHLSALAGSAVAADSNTVDDRFADADEDCGLVLGRRRKSSALSRGNSVRSRAGQIHAAQAAHQAANTTVASAASRLNAAVNSESTTSLGSLNTHSLPGSVPSLSPGSSPTRASALAAQQEEPAGSILSDVPGLHSPQDLPVTPKANSPRDERGPVLSASNSKAYLPRPRISSGDSIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR00</accession>
    <name>K1VR00_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR00"/>
    <dbReference type="HOGENOM" id="CLU_821801_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR00"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="36522" checksum="A1F99968DCCA89A7" modified="2012-11-28" version="1">MSTTSDFVGFHHACFPHLLSSVIDNADYATLLALRQTSSTVGAEVDRRLFRHALVQRPAWPPAASPLFVGNGDLNPATGSSSKLSLPIPAGDSEGEKARLSRVLQQVRIVDDVSGGILVGWRKDLAPTVVRRKGLAEATLSAPSLIDAVDVPYSANANWAVTASMQRVPEGVHRYAAHIRCLAPPGSGPRGPAHVKFGCALPSSVEEVSLLFSTVGEEDFNPMHFYAPTEGKATLLSLLVEQVAADLLLHPSRTFAFVGLESLPGRIYDAQFGDEDVAENFLERLLEQIECNADAEETERILERVKIMTKESYRAQVGEERFALEAGWNGVAGAPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS80</accession>
    <name>K1VS80_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS80"/>
    <dbReference type="FunCoup" id="K1VS80">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS80"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_0_1"/>
    <dbReference type="InParanoid" id="K1VS80"/>
    <dbReference type="OMA" id="QCSICES"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000132">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="350" mass="38702" checksum="B7642C2F84E19730" modified="2012-11-28" version="1">MPTQCSICESARALVKRPKTGQQVCKQCFFDVFETEVHETITKSGAGGGSIFERGERVAIGASGGKDSTVLAHVLTTLNQRYDYGLDLHLLSIDEGIKGYRDDSLETVKQNQAEYGLPLKILSYDELYGWTMDRVVDQVGKKNNCTFCGVFRRQALDRGAAELGIEHIVTGHNADDIAETVLMNILRGDVARLGRCTAVTTQGDDTIKRSKPFKYAYEKEIVMYAYFKKLTYFSTECIYSPEGSGGSAPLSDHRHHPFRRELRARQEDEGQLEVHAAADTSPRTISAKPALSCRVSRADLIARLSYSPSGEAPAGQRTIPKYQRKLRVAEGTEGVEGIERPLAKLEVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSD0</accession>
    <name>K1VSD0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein sec66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSD0"/>
    <dbReference type="FunCoup" id="K1VSD0">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSD0"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066294_0_1_1"/>
    <dbReference type="InParanoid" id="K1VSD0"/>
    <dbReference type="OMA" id="KPWFPAH"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24784" checksum="CA9971E6B517A555" modified="2012-11-28" version="1">MATSLAVPIAYITVLVTAMAIFSRIYRRRRAAEKTSFEPWFPAHPARDIYITLLSANPPVPESMLKSALLVRATADVKRIWRIKEDKQALASLHQRGLVGDDTMARFAAAEKELEAEIVDVVSEANTFRNGWGSMIFATASEMAHSEKTRDTVISVGRARQLEEKRMEKRAKLLGIPMHQVPATSMAEVQAVAGSAPSSGAATPNKSQSNTPKKVSPPNSRKVSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSI9</accession>
    <name>K1VSI9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-1(Or 4)-monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSI9"/>
    <dbReference type="STRING" id="1220162.K1VSI9"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="InParanoid" id="K1VSI9"/>
    <dbReference type="OMA" id="CHALRIM"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="244" mass="27075" checksum="D07030C0E0D2551E" modified="2012-11-28" version="1">MSDEQVYQEILEFAYDLVEKASKLILEGSAKRWTSHDFATKKNAVDTDGAVEEFIKKAIAEKYPDHKFIGEETSEVQGKPVLTDAFTWIVDPIDKASDISPMVGCSIGVTHNKVPVVGVISQPFLTRICLVAAEWGSDRSIETVTPKLNSFKRLNGDPAKGIEGGVLCHALRIMLKEVGAFFSGGKELFERDASIGEVLMCRRYIAIRAVAPTETESSEQIQRRLAKDLYEVVEPWTTPSMKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSK4</accession>
    <name>K1VSK4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSK4"/>
    <dbReference type="STRING" id="1220162.K1VSK4"/>
    <dbReference type="eggNOG" id="ENOG502QV53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364155_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSK4"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="85453" checksum="90A72E42712E5E0B" modified="2012-11-28" version="1">MNTANTSQDDADTSPGTRKRRTLRACDVSHPHRLCSTHPNASGVLGVEQGADVDADHGQHSLTKQGCRHRRMKCEDVQTTASGKQRCRVCRDNRQDCTFNAPVLKRGPRPGWRQRLLERSVSPPVGNTNTLGLQQDGQQQQQQQSWNAGASNTEEGQEPPRSKRRQSTPSPDGQPRSRAQQRLPLLGLPPPLVDQLLAVYFTHVHTGCGDKNLAFTYAGRACCMALSMGLNLAPAQPESPVEAETRSRVYTLAEETGRSILLPYRRSSTPLPSMTEADEFELWPPIPSSSQPLPESVQHLTPRRGYVMSCFVWTCYLGMVVEGILELDVPGPPRPRPSETPWFNQWSAEKLEEERKQVVTTAARIARELESWRNALPPYLEVDLQASPMPHLTISLAVSYAASERTDGQWYETAQILLYSHFIRSGPLPEVLTPDASAEHELISKAHSTCTAAAEKCADFISHLDKHRLLSVTSADIIHILGLVTLYEAFDASDPDEELAHRAKLTFAQCCIWLRDCSSAWPAASAHKVFFEGLIQGGIKLSSTIHETESSPQPLDAGLRGLGNKLRSPRADFDTTLPPLGRSSLFQLPQFYWNQLSNAIPGQSTATFSAEGNVLGIAQSPDMPFIPPALSPESQNQQTDMSPYQRQNDSASQQEWHKQQQQQTQPQQPPQTQPQQNQQQPLQQQPQHHHHGHHHHHHQQHHQPHQQQQQQTNPAQNAMQPSQFFDMVNFNQSWNSGGMDANLGASMDNSAVYSALMNFMVEAARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSL3</accession>
    <name>K1VSL3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative retrotransposon nucleocapsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_03148</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSL3"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001577_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSL3"/>
    <dbReference type="OMA" id="PERWHTI"/>
    <dbReference type="OrthoDB" id="3262968at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="12">
        <location>
            <begin position="739"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="598"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1470"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1480"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD02552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1796" mass="203394" checksum="ABD332E82403E6F2" modified="2012-11-28" version="1">MSEQRTPDPAADEERRRQAAEEKAGAKGKAKAGTQQPSDPAQAPQDDDTGVNPDNMSEAEFRRLIMTTLTGLSKDTRTVVSELDGVKNRVAAMEISRANSKQSKTSPSVTSGQLETTQKDAPPDKPPILHPKPKHAVSPTKLQAIEESADNIRHGEGGGGGATRTSPITQRVPEQDSSAPPGTDLARAADDNDRQPAARPATRQNGQHGTHEHHRLQQHPPDDVFTSSQPVLPQNQVHSNLFSPVQQHPSARQPYSTMMPSGAMAYPHPVYQPQLPPVRIETKDLPQFEGFEDKDGIERFVRAIDVHLRTGVSEYQIIARLGTLFHGSANEWFITLTDGELERLRTWSDWRARLLETFRPTNIKLIEQQAAAHRIIRNDEDVRQYFHEKKNLLRRGNPSMSDAEIGLQILGGTPMQWRANVTWDPDRDSLHDLQTSMERRAGLLHAQWWDKNLDMRDSNGHPRPGYVSWLSDLSRSANSRAPKGNKNQQSSSDNNNQSQQSRDTQSNDRQQGQRSNNRNANYGHNTEDYKRQWLDNQRKFLGRDPRSRTPLPRDRMRPQGRPFAPPASSADEQDVYIDDPYDLTYRPNNVYWLAAQEKRKQQNDVQNDNNALSLRTTPRPQQPTPPTHDGCSLKPHDTPIPECTATIELLPSSDDEEQDDGTKDDAPRQKKKKKEKIANAGETSSETKRPSCTQTPQAHVYDVSSAPVADAELNDWLQSDWVPTPTLAFARIGTSNQPHRVLIDSGADLCLVGEAYLRNEIENYNIEDSAILTINGVNGTSRTLGSTILPLRFSRKDARGHDQVFLIRFHVVPDLKDGLLVGNNALIAMNAVIDLSRGRMKLQDQEYLITSARRRRQDPMNYGHARDVRLKNAYIIQPGCRMKVPVHVITGGFKSDFLIEPVPLENGARLIRGPRALEPAHTDEVMYEFFNGTRKPIKLKRGLLVGKAIPKSRDQVRELKDIQQVVDSLSHELEKTKMANFINTEEDYLTSEDWEEYKTLLDKININENLDNDQRRKVENLLYCKRAAFASEKNPIGLTRRAVFDVDTGDAKPTTHCPYHASPLRRKLIRERIKALKDMQLIQDSTSEWSSPVIMVEQNGQWRMCVDYRALNKITVGDQYPVPRVFDILDSLEGSHWFSSFDLNKGYYQIPTTPRAAKRLAFRTQDGLYEPLRMPFGAKGAPAAFQRLMDTLLAEGRWLWCLAYIDDIIVYSKTFDDHVTHVRWVLGQMIDGGLTLHPSKSHLFVNSIDLLGHHVSNAGIAKGKKATDAITKQKRPTTVKELSRFLGLASHYRRFVKNFAILATPLRELRRLAVQLNSHHLPWNETYEAAYNLLIEKLAEDVLLTHPNPDKKFYIESDACLDGFGAVISQKTPEGYLRPIAFISRQTVDGEKNMAATELECAGLMWALEKFRPYIEGGTVQMLCDHKALQQLENYKGDCKRMQRASALLMSYHSTIDFVYKQAKKMQHVDQCSRNPLPATDRDRARPEEEIPEPWMGGTPIHPPPRGARTKPDHSASIITDELGDLDEGAVHAVWEILPDNDTIRRINEAMYDDPKFIKIVDEILFRYDVPDTKPYDREHWRKTMWHPSKPFVLSDGILHTVHSNVPRFMIYVPDDKSLRDDILSRFHDTPMAGHRGSESTYLRLVEHFWWPGVQRYVRSFVRHCESCQKNKPDNLLPPGLLKPIPHCPERWHTIQMDWMTKLPTSNGFDACLVVLDRRAFDSVLVSIDPTLASASFSQCILPDLVLVGYSSGVILATALEGVWASVARCGWRLSAHGVRRPHGLDKLALPPGLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSW9</accession>
    <name>K1VSW9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSW9"/>
    <dbReference type="FunCoup" id="K1VSW9">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSW9"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1074374_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSW9"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="259" mass="29298" checksum="50E22D6565F29F22" modified="2012-11-28" version="1">MAEIEQWFQAIPPVTRAWFVASAATSVLVVIAPLQLYFSWKAAVIKAQPWRILTTFCYFGPISFDLAFHIFFVYSRLLEEHSFMNRRADYVWLLMLTAGFLLAISPLVTMPFLSTPLSFALVYIWARRNPSIKMSLFGVVTIPAPYLPFCLAAFSWLLQNGFQGALGDLLLDVLPHEPVDTVPHPSLGLARSRLDPTYPLPRPDDGLNLSRDKRYRNLPLVLRLLQPTHGSVGVRIYRAVYAVALDPAMALRDEDARSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSZ6</accession>
    <name>K1VSZ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="15">PARP</shortName>
            <ecNumber evidence="15">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_02058</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="15"/>
    <dbReference type="EMBL" id="AMBO01000243">
        <property type="protein sequence ID" value="EKD03641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSZ6"/>
    <dbReference type="STRING" id="1220162.K1VSZ6"/>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007467_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSZ6"/>
    <dbReference type="OMA" id="DCEANGK"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
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        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
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        <property type="term" value="F:nucleotidyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WGR_PARP"/>
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        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
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        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARTD/PARP"/>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
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        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
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        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="TAT_signal"/>
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        <property type="entry name" value="WGR_dom_sf"/>
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        <property type="entry name" value="WGR_domain"/>
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        <property type="entry name" value="PRK11873.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="20">
        <location>
            <begin position="211"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="19">
        <location>
            <begin position="336"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="18">
        <location>
            <begin position="470"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKD03641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1121" mass="120367" checksum="A899ED0B8064193C" modified="2012-11-28" version="1">MPPRRSARGAAAAAAAAAAAPVPAPAPAATTSAPTPSPPPQVKKNPFPLRGCRIAVSGALPGLTHEDVLERAKKLGAATTQNVTATVTHLITTEQEVDDETPKVRAVKRFGKAKMVSMDWLEKTEEDGERAPEDEYELKPKDPSAVASSSKAAPVANGTAKANGTKRAASPALPAPPAKKRSKKDEDLEPSAQKATSKDICVMLDEGAPANYNVYIDSDLTIWDASLNQTNASNNNNKFYRLQLLQNGAIYKTWSRWGRVGERGQSALLGSGSLADALKQFEKKFKDKSGLKWDDRSSAPKVGKYTFVERSYAPDSDDEDETEDEVKKEEEYETPKSKLPLQVQQLMEFIFNPTFMNATMADLNYDAKKLPLGKLSKNTITRGFQTLKDLMELIDDQSLAQSRYNMAYAPAVEQLSNQYYSVIPHAFGRNRPPVIANEAMLRRELDLLESLSEMKEAQNILKGRKDSRDNPADAQFEALGMEEMTPLDHSSSEFKQLAEYLLETKASTHYVKYQIEEIFRIERKGEEDRFENSKFKDVKSDRRLLWHGSRTTNFGGILSQGLRIAPPEAPVSGYMFGKGIYLADMSSKSVNYCCSSLSNGTALLLLCEAELGDPLQKLTNASYTAGDDAVKNGMYSTWGQGTTGPSKWKDASSVHERFKGTKIPDLSAKPGNTGVPNAYLAYNEFICYDVDQCLFLVRERDGNVDYAAASLPLFPLKLRAARPPPPLEAASLCCKKETAPSSSCCKTEVKEEAGCCKPDAASASCCEKEPAPSTSCCKADAAPAAGCCKPRTASSSCCKTDAAPSTSCCKTGAVPASSCCKPVAAPSACAPKTASGCCGPKPSNATHDAVRSAYGSAVTSVVSGGGASCCGSKATELSGVDPITKDLYNELEASEVPAEALLASFGCGNPTALAKLEKGQTVLDLGSGGGIDVILSAKRVGPTGKAYGLDMTDEMLDLARRNAVTAKVDNVEFLKGHIEQIPLPDCSVDVIISNCVINLSPDKDATLAEAYRVLKPGGRLAISDIVLNRPLPTETQQDLKLWAGCIAGALVKGDYEEKLTKAGFKDIDIEPTRVYSSEDAKEIVDGQGDEKDEQLKAIDGAAMSCFIRATKPTSNCGQKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT14</accession>
    <name>K1VT14_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT14"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_122_1_1"/>
    <dbReference type="InParanoid" id="K1VT14"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1669"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="825"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1451"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1959"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="529"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="637"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="672"/>
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            <begin position="765"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="792"/>
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            <begin position="993"/>
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            <begin position="1100"/>
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            <begin position="1183"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="1258"/>
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        <location>
            <begin position="1305"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1371"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1453"/>
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        </location>
    </feature>
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        <location>
            <begin position="1470"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1505"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1521"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1987"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1698"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2085" mass="222215" checksum="DC31B3F1FB14CB6D" modified="2012-11-28" version="1">MTYPAARGSPPSAGPSHTPSVAAGYSQHSIPGSASWNSSPGGPEMVAAQSRHTSPASRLSSQPSAGSFGLYDQTSRVPTGGSEGATEMNSGGAQMRSDRTWAGPSSSAQSSVSRPPLVPRASDPYAFSANTSTTSPPTSAYSSPASAPSAYARERVSASQSMSAMGSSTIGLKGRRAPAPAALDLSTRTEPPSTTMPLLDFQSNPSRPPRAPGRQKSMDMPVPRPLPTAPSEEGYKPPSPVLRSVPGRERRDSIPFPAHQLPPSSSPQGLLPSSLSSSVGIDTRRQSVIDRRESVATNGDRVSIDSYYLGAGANGGLSPGDMGSTFTPTTPDPLDPSNIDRRGLVGVGELATPRWGPSSRHLRTPSMSGGNGGDFSLAPPLPQSASGLFVGSAPGRHVWDPSGEQLAGPASAYPNHVEHISDDVMQTRREREQARARHRSVSHETPKRPPVTKRNSTQAGVKALDSLLSLSSLNDFNFDSQIDSTGGLAGSLSPLNQSQAQQQPPGSLSAPTSPPREVNVRASAPPAPKSYSAQALSLASVPPLPPKSQRRQTHQLFTDPPAVPPLPTKPFDSPTSPPLPGSARERIYARRASRQLAAAAAEGLPPPKPVEIPPLPINSYRASPPGSADSTTPSFTWRDRKTPPSGGGRDRETSISSQTTAKRRAPPSPSAPHHDILRHIAPKDFSHLPPSPSTASINQFLRGSSSGQNLSTVRTPPGSVSGHSKPPLQRSESTRSRSRAQSMKSGEVAATVEALRKLDGLGTTPKKQATNTAATPRPHPGTPPETIRKSSSKYSTLSLQVTSSREKESPLSNWFEASHSDLAATATHARARRETYTAGSSDVPPLTFEKRESSPSVVGTPTSRDSLIPLRGSGTPPTSLRDIRAEKAARRPSVGSDISSLDGNLDDRTSDSFVPPVPPLPRGYMSMRSGLATAGAATQVPPSGSATHLPQTGSTTTLPTTTESSPTGSPTLQAPPPMQYVPLQAESAQPAQSVESTASPRSPSSTFPSPQAHKESPEVPTPVSLTLSDGSARDTPARRSMSKKWSFSSALSLKGLHNKEKDVMSSPNSSFDIGDSPPRAVQWPEESPLVPTRTRDSIDVHSTISDARSNHSTTPIAPPSNLAPPSRSASKRLTPSSIPFFRRSSASSASLSQKLASPPDAQASRLSVQASSASTSTNSMAQRTPSSARKSMLSSMHIPSMLRVSGSKRGISHNQLSPQEEIDTGEPPKSAVEPRTKEPSLTKVGSIGRSGGRPRRLTLSSGGDENNASLSRNPSMNVQPNIMHQRSESGILNGLPVKGTRLPMASSQHGLHTASSASSLRKDGNRPPPSATPTKIPRMTSRPSVVTPNTQALHMTSPHTSMPPPALPSGMATSRSANMLSSSGNGHLPSSTSVNDISPGDFGSIGSRQSFQVGSSSAAHRSHLLAPMSARKHSVSGIPAPPVSRRETLAIAPSSNMITPSRRTLPQLPSSATTMTISSAAKVRPAGTRRGSTSSQTDNTDDNSAKQPIKTSKSFHTKGISAGHSRMSLSSSAGASRRASLAAGDTSSHDSPTDDDETMADAEMAQYVVRRKARAAASHSKKDDLSDLLGFPEDIQPAEALTQRQFISRNLGSLSDYERKEVLDFDHIYYTVTGVKRPVGADGKVYNHGYDDERGDYLVVEGDHLCYRYEVMGVLGKGSFGQVVHCRDHKTGGSVAVKIIRNKKRFHAQALVEIKILQQIVDWDPEDKHHMVKMTDHFYFRGHLCIVTELLSINLYELIKANQFNGFSTVLIRRFTTQMLSSLVLMRSHRIVHCDLKPENILLRHPSKSGIKVIDFGSSCHESEKVYTYIQSRFYRSPEVILGMNYAMAIDMWSLGCILAELYTGYPIFPGENEHEQLACIMEVLGVPDSYIVQKASRRKLFFDATGAARPFVNAKGKRRRPGTKSLQSVLKCNDEQFVDFISKCLTWDPDKRLKPQPAMRHPWILAGRRRAPPPPTSSQTERDGRTSLLSSSTSSRRQTTQYSNGGSSEKKGLVISPPTPLVARAPQSTSTPRVGVPATARLHARNSAYARSVRSERVIEEGEEGKVAKCGGGGKGQTWTIKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU10</accession>
    <name>K1VU10_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU10"/>
    <dbReference type="STRING" id="1220162.K1VU10"/>
    <dbReference type="eggNOG" id="KOG3958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1574511_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU10"/>
    <dbReference type="OMA" id="IMDERMT"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="19251" checksum="18290081E9389967" modified="2012-11-28" version="1">MDSADDQIPVSLMESLSRLDNLLNVLTQPRHLDGISRRVKMLLNDLERAGASARRNAGAGSSPEKAAPSALSQTDQDTLQDLFALLPRLDPLIPTIPPLITRLRSLSQLHAEALSIAADLRELQSSSADASDEERELNAIVKSVHIGFTEAATGIQKNWEALQGRIQGLEGRLERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUB6</accession>
    <name>K1VUB6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ER to transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUB6"/>
    <dbReference type="STRING" id="1220162.K1VUB6"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1866531_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUB6"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="137" mass="14828" checksum="2AF93975344827CF" modified="2012-11-28" version="1">MLDTAAAQAIITSLVRPQLTTGFYFAVQSGGNFEISYSVMDPKDKVILEGDNERQGDYIFTAKTVGEYSFCFNNDATDKLIDFEYVARLPKEAERVGAIFAGPSPWSRPGSGLLDPRAATTRLRAPSSPSAPPFGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUJ8</accession>
    <name>K1VUJ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER to transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUJ8"/>
    <dbReference type="FunCoup" id="K1VUJ8">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUJ8"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUJ8"/>
    <dbReference type="OMA" id="AMDYFLI"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="29405" checksum="B9CF5F1617C7F3E8" modified="2012-11-28" version="1">MDATASPARPASTATTPHAPITPIVPQAVHALAAPVPNLIDTALPGYLLPEVIRTLQDSARHAVEQRVAAERDAGTGQEEDVDIAALTINEKRHSVPPKDKGKGKEGMVEDAVKERLERIGYAVGGYVAEKLTLARPPLASHLDMIKFVCKDLFLFVYAKQIDNLRTNHRGVFVLQSHAFPPLASLSSTRGTQHDIAVAKVHLIYPQALIQGALQRLGMQCTVTAETSQLPQCTFQVRVSKHRQASEGPGHAAQESVDRRRSSAATSVMSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVH6</accession>
    <name>K1VVH6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVH6"/>
    <dbReference type="STRING" id="1220162.K1VVH6"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_3_0_1"/>
    <dbReference type="InParanoid" id="K1VVH6"/>
    <dbReference type="OMA" id="IGRADEN"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="32049" checksum="117D29803FF7893D" modified="2012-11-28" version="1">MVGRIENTLEEIRDKFNPDRIIIDGSAFPATLALQIRKLEPEGFKLDGVVTVIDCKNFKGYEDTSPSAKLQAKYTDLHLLSKHEQCTEREFDILLDHLGELTDQTPYIKVSKDKPIRPEVLFGLDTQLFKLEDEQNTWEALGGEGKHMDEVETRSVWRGGAQPGKHEHAEGETCKSCPKGEAVEGGLLSRDQLDAALKLPFEIYRVKGIVRFPAEDGKRAVNGEAKNYETYILNWAFGNYDLTRAPKLDDAPDLEGVVCRLTVMGERGEVNRKAKKIAEALGAQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWE3</accession>
    <name>K1VWE3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWE3"/>
    <dbReference type="FunCoup" id="K1VWE3">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWE3"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_3_2_1"/>
    <dbReference type="InParanoid" id="K1VWE3"/>
    <dbReference type="OMA" id="VDNEQMF"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25598" checksum="0023E51C69586EA6" modified="2012-11-28" version="1">MSTLFTTLKSNQSRTFKPKKVQEGTKQWQLKQYAQQTLGSGNLRTAVQLPDGEDLQEWIAVHVVDFFNHVNMLYGTISEFCTPTECHIMNAGPKYEFYWEDGDVYRKPTPLSAPAYVEALMTWTQSLLDDEKIFPQRIGVKFPSNFMTTAKTILRRLFRVYAHIYHSHFDQICGLGIEAHLNTNYRHFFLFVDEFSLLSERDLMPMEELNKTILADTLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWS0</accession>
    <name>K1VWS0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWS0"/>
    <dbReference type="STRING" id="1220162.K1VWS0"/>
    <dbReference type="eggNOG" id="ENOG502QWDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494478_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWS0"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="60"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="551" mass="60975" checksum="5A6F1DDCBDD18757" modified="2012-11-28" version="1">MLAISACLCPPQTDGIDGDKLYAMAESALHHCRNESRIDIIQALMILSLRQTGVGDKRSAFTYAGRAATMALNLGLHLAPTTPSEAGECELRSRVFWNVYVLDKILAEELGRPLFLRYRRSSTPLPSETESDEFEPWPPQSPSSAPVPAPVRHITPRRGHIMSFFVWTCRMGMIIEDILDLEVIGPPVYDSWDRRFIARIEAEQDTWRRAERIAEDLVAWREAMPAKLEVNLDPNVSPLPHHVVGLSWYHTARILLYSRFLRRRSGHGRGPPSLVDKAHRVCSESAEACIDMLAHLDRHKLLSQCSSDCIHMMSVITLWEAFDASSSDPAIAHRAKLNFAQCCIWLRDFSSSWPAASAHKLFFEGLIQGGLKLSSGDMFREDHTPESEPRSGEPGVTITEGLRSMGRNLADGDEDDTPRQQTSGHELGQPISQDSQLAIGQQGQQQQPNLFNLSQFYWNHLTTTEPAPGEGAGGWELDPGLAPQNMFGSPAEPMPPPQRTDSTPPVQFAGPSNYFDGGGQWGNPPAQGEGSDQAAIYAALMSYMVEAAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWU4</accession>
    <name>K1VWU4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARB-07466-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWU4"/>
    <dbReference type="STRING" id="1220162.K1VWU4"/>
    <dbReference type="eggNOG" id="ENOG502RZ4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1416095_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWU4"/>
    <dbReference type="OMA" id="REGECRD"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058593">
        <property type="entry name" value="ARB_07466-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26571">
        <property type="entry name" value="VldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854076" description="ARB-07466-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ARB-07466-like C-terminal" evidence="2">
        <location>
            <begin position="76"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="192" mass="20759" checksum="3FDD61DE5BE0E21F" modified="2012-11-28" version="1">MRLFLTVLPLLTTILAAPGEPCISDSGEPAARLRPLVRTTDWYAAPPTAPATPSTAPAGGAAKYGPYDAPAIPEVGSCKAQTVAGAKKVVEAFPGRIWSAGCYREGECRDGSEHPCGRAIDFMCSDETGLGSTGCTDIAEWVMHHTSELNVYYVIWGQRIWNGGRDKVGPWSGWRTMEDRKSITQNHCFNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWX2</accession>
    <name>K1VWX2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWX2"/>
    <dbReference type="eggNOG" id="ENOG502R0EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321878_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWX2"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="101471" checksum="DE67D09CCF8E663C" modified="2012-11-28" version="1">MPPSLPSSLPPSRKASLQFILSPTGPSPSSTDSSPPQTYDYASHHVRRPSSTSSSGSMRAGGMVHSPSSFNASPTMESSSSHRPLPELADMPAEILANIAYHVVVDTKDGRLKAGRPGRLFPLYLTCRSIYRKLRIKNNPVLYHWLFRDTFDTDGLIRRTQWMYDIRKTNKPGEVFDASTWRTLSSPTFSDPKAWAREYRARWDLRNRMRWAVMHQTLSPNGVSAHPNMTSDNWILWFLFSENDYRNLAFLTDECLFHKWILLEYNENVLAASLKPGFPEVNPTRSLACWITLLSTCDLFGERTPAEVDEKIFLFRPFVFGSAQFPFEYADWRYRKLPVCSPQCKEHQPIARHLAPYSRFGHSHMRAPPNIATSAYIMFFRLLARHPERMGIKPGSTLWVDPSPKGLFSETHLLPSLYHDLEWQRNSVCQDAHNGTGLPPLTFHKRMSGFWRGEMLFFDFEGYRQALSGNVHAVQTGTFHRNGVEIELEETVIRVPENEVGGRGKLMNAGFGDEDSEAEINFIRAGYGYKVLTGDELYAPEKPGWTKEILLSGRHRCGWGNATIRGRIRSWDGLVLLSVGEADKYPVGRWLLRGYVHVNGGFVGKWRDCLTPENRHGYEGPFAFLRAGDVFYPDHMPKTWEESKGVVMIDTLVGGMQADSSFPRQPMKSLSASSQASPVNPGSQSPTMQNGSGLVKSPVDMPREFGRDVHRSPTQASQASMSSDSGGKRRWSGEEDQSRPSSRAKSEDHGRPSSGGDMKPLTRGFREHHITNGDRPRSYAEDGRSQYMDPRYRQPVDGERFRYMDSGRPPRPSSMEFKQRDSDRYRSANGDRHPSYGQGPSDHRGMDVDHRPGSSRSSVADGGRPISGKGMDVDSPRSSGGYWSGSGSGRRGSDADRHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWY1</accession>
    <name>K1VWY1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWY1"/>
    <dbReference type="eggNOG" id="ENOG502QSSD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030126_1_0_1"/>
    <dbReference type="InParanoid" id="K1VWY1"/>
    <dbReference type="OMA" id="YIWNAAE"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40880" checksum="54BB62E3ACF0066F" modified="2012-11-28" version="1">MPHVRAKEYQIPKEGYDLVYVEVIQRHHKRTPYASNTFFKEDTDWDCSNAGPYHHAKAVDFATTPVYWQAQHSALNPFASQVGPGFGDSTCQFPGITSAGLDDSKQHGVDFGSVYRDKLGFLPCANETEQYAFRVTNNVITTQTLGAFAAGLYPDAKEYVAWVQSETYDSLEPKFSWTEHLEKSAALRERFNRVSGIEPNDSAGWSSSWDHVNATDVCVSQEDADAIYRLGNWEYAYRWRGAENSTLYSALKMGVWFRELQANLHAAAEATSPVNFAHDGSVSPVLGVLQSAYPIWPGMGSEVVFELWRKGSKPYVRVLFSGQPLETATPLGTLDMVPLDKLDSYFDSIIPRDMVAACRGDAAALGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYX1</accession>
    <name>K1VYX1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYX1"/>
    <dbReference type="STRING" id="1220162.K1VYX1"/>
    <dbReference type="eggNOG" id="ENOG502T1G0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068527_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYX1"/>
    <dbReference type="OMA" id="YAHASCA"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35563" checksum="090C3F131BC19EA4" modified="2012-11-28" version="1">MSRNLRELELEQALDKHGYQTVEDVTSTSPKDLAVGKYELPSTVDIEDLGIGLSQAEEVLRLVTQQSGELHRIGRTDPSARPAYVPTPAKSVTASQLLKVSPTYFSTLSVSLDKLIGYYVSGYTAPHGLNLKGRGADREDSGSIRPGAVLELSAPPGGGKTGAIIGIALSARTIDEDTPEVLLIGSITEDRLRSAAESLGNADTILGGIYVMRVGTQLQMITVLQMLDSWLTEHPKQVVATTQMATKLMTIDNKPATFETGDRAVLMPQLGDAWTTERTIRVTLFRGAKDDLRYAHASCASQPIPSEEEVPWASFDIDPNLLTRVTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYZ7</accession>
    <name>K1VYZ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYZ7"/>
    <dbReference type="HOGENOM" id="CLU_380904_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYZ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="736" mass="79490" checksum="5A0AEF5EBD06A2B8" modified="2012-11-28" version="1">MHMHIRPSAMSECGGDPQRAPVDDDDEAQGAHSDQGAQGGMARGRNRHHDMPLPDQSQQQACLQWPCVAPWPCGFVGSSIMDARSSDKRLVTSLTSLLNPRRRRHHQKRPSSSTAAVYSPSDSSSSIQQTPSLRPSSNEAPARDVCNSTSPEASAIYGPPPSDSVLSTSFPGTSTVVPVLNRPAAGYLTSAIQAGPNLQESRRPRTRTVPRDAGALAGLAAVRCTTPAFPVAERLLVMNWPTNWVDAQGLPLYQLNGTVPFTGPHSSTHNLAIPPDQAEDAFPAQYAYSPESDTQPLPATRRGSHGVRDDDDGHRWQTRPAPQIPRGPSGDANHFWQLHGPRRYTYGCTLSVVAEEKGAEDDSGLDLSEQSSTESSSSGTSTETSTSEATTFNHLSAKTSGDSPAPQDHSPKQLDPTVHLSSERRLSIDMFSDDDTFYDAPSQLGSPLPVDWSSDDEGYESAEAGSDDSVFDAEICEAIHCRRESMFSDDDERFSLFSNSRRPSLATDTSSRRPSFATAHEFSFDSRRPSFATTISDEAIEDDDDDDGVSPVSPTTGDMLINIWKSKRSSMLFIDPSAPLPLPSPALLDTPVSPRVPPSPGAASFMSAARPESVLLPDDAEPECCVSESPQQIALSLDSDLAEDEEDPDNTLATLKDFEQEPASIARVTARVYLSGRVAPAQLVYYELMLAASETAQYSRLSRGLPPPGTKRRGPPKAIEVSNGRNSRFFSSHAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0B5</accession>
    <name>K1W0B5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0B5"/>
    <dbReference type="FunCoup" id="K1W0B5">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W0B5"/>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_1_0_1"/>
    <dbReference type="InParanoid" id="K1W0B5"/>
    <dbReference type="OMA" id="ECSWEYL"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="62"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="381" mass="43261" checksum="CC24AF2324DFA319" modified="2012-11-28" version="1">MDVTTPTNERPGPVLEEQDGLMPDLPVPSLVASDESSPELPPIVSPGLEDKPFDLNAAPRLPECWGHRGASANFPENTLMSFVEACKAGADGIETDIHMTSDDELVMFHDPELHRTTDGKGRLHEQPWKGVLEHVRTLEQPAQPIPRFAQLLDLLQQPENAHVKVNIDCKVENDPVRLFTLIRAELERRPDWETTLAPRLILGLWHPKFLEPAMTLLAPLQRFCISMSLSQVRQYFWACTGFSVYYPLLLGAEGEKFRLECAAAGKKICTWTVNEREEMLQCVRWGVYSVISDRPELWRQLKRDIAGDAKVAKPTFWNETVLPYLTYRNWWFDTRAKERFETEYLEREGGKFFVPLTPPLEAVDPVGPAGGVQPLRPSQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0I2</accession>
    <name>K1W0I2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0I2"/>
    <dbReference type="STRING" id="1220162.K1W0I2"/>
    <dbReference type="ESTHER" id="trias-j4u9s5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_2_1"/>
    <dbReference type="InParanoid" id="K1W0I2"/>
    <dbReference type="OMA" id="MINAMKF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854487" description="Carboxylesterase type B domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="51"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="611" mass="65970" checksum="E6A0D87B225B995B" modified="2012-11-28" version="1">MLTKTLAALALGAGALASPTLDLARRDGCTLSWNGTDITGTQDGGACRYTVRYATAGRWEYPVHAQNQTGVDAAKFPPMCAQGEKNRLEPAEADFQPMSEDCQFMTIFTPANITKDSKLPVFYWIHGGSYVGGSASDKGLNGTSMAVNDDIIVIFTQYRLGILGHLPPPVAPTGGDPNYALHDIITSLEVVRDNIGAAGGDPAAVTVGGQSAGASMTRALWATPAAKGLYRGFIMHSDPITIGTQGPDETEALQNLVYNNTAGNGTMLAQLNCTDFACWQNANLSLVINASDTVNTLGPKKVFSVTQGEVFRPSYGTKSLPQDPANALFYNNTNLAFNVSEIPLLITTTRNESGYLVDAVAQVNISANDMLFNLSLQSFEHNQTRVDYIINSGHYSMPNNSDGLREALEVGITDVVWRCATRAIGHEWARQGGKIWIGEWNRGIQYTFDNGTYCSGNNVVCHGDDVYPTFNSQPTDKDSEDEYANWGAQIHGAWASFIKNGDPTKAGLNWTQWNENSPKDDVFNIGQRNEIRECPKDLWGTDKFPWYWQIYSNETIVDLGTGNHTAVDKDDAPQATGSGQKNGQSTDKNAGMKLSAAGGLTLSAIALSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0J4</accession>
    <name>K1W0J4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="14">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_03144</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0J4"/>
    <dbReference type="FunCoup" id="K1W0J4">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W0J4"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009884_1_0_1"/>
    <dbReference type="InParanoid" id="K1W0J4"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="144"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="280"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="631"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD02548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="772" mass="84401" checksum="EF346081DEF7E792" modified="2012-11-28" version="1">MACSHVEALASSLKPPSPSQQVHREECTLCFDGQCFNGGCFGEDRKHAYLHSQKKNHPLGVVIKRTRKEQKKRDNSEPPMKKLAISAPSDEETYDYSTSVRCFGCSPVGEAVQVDNPAAAVDGIMKALSSAQQSEVKAWEEEIIPCEHALTLEQVPLITPGEVPSQCTECDLTSNLWLCLTCGLANCGRQQYGGIGGNGHALQHFKDTGYNAETELIQDIYCYSCDDAKIDPDLANHLRTFGINVLDQSKTEKSMTELFDFSMTGDDGKELEPMFGKGLTGFKNLGNSCYMASVLQTLFSIPAFHQRYYTEAAMAHPQTCDKLPADCLECQMLKVADGLLSGRYSKLAKAPPPANSEFEVNEEPKFQDGIRPAQFKALIGKGHEEFSTMRQQDSEEFLGHLLSRLRQEAKSQGRPESSEATDALRFGMEQRLQCDECKKVGYKVDSVDLVSLPVEAGETGVTEDGKKTFRPVTLESCIEALCAPEELTDYACGTCGKRVRAETSTKFKTYPELLVLHMKKFQLVNWLPTKLDVPVQAPDSLNLDKFHGTGRQPGEEELDIDAAPAAAPQFDPVAMSQLEAMGFPTVRCQKALLATGGNDAEMATAWLFEHMDDPDIDAPIPTAGGSGSAAEPSQEQITMLSEMGFTPAQARKALRESNGNAEHAVEWLFSHPDDDGEEEAPAAAAGSAPSGEADVGGTPPPANYRLKAFVSHKGPSVHSGHYVATIRQPQKGLADEKEDEWVLFNDEKVVRAPPGGGEEMRSLAYLYVYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0N7</accession>
    <name>K1W0N7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000095">
        <property type="protein sequence ID" value="EKD05387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0N7"/>
    <dbReference type="HOGENOM" id="CLU_734006_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0N7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="377" mass="40571" checksum="6C15EE7E2C67E46C" modified="2012-11-28" version="1">MGSLQRALKAHQARLDALTRDVGELSERSERDRDLARDIGQRAREISRERNPHPAPAPVPVPAPEDREKTKYTAKEARGGMWDEERRWGDDNYAAFALASPTSPCAYDGAEIRIGDIVRGPIHSRSASETATHSRSASVGYDPASVSDPGHGAPSPSPFAYGPGLCSTAVSRSGSAAGTYPFPQAHPSTQTHSRNNSQNAPYAPQPYAPQFGQSLGVNTSTAPGYKESFRPTTPGFDDMEVLTSSDPFAAPLPGGKRGGLVAPLPHGLRPGDLMTPPPSHSNLPYTPPPSHTPTPSNRQDSDSPDSLRDRRHLRQLEARLATLEAHIGLVPGQTPTEPSMDQRLVRLEMSVGQMIESSGAMPADSMYDPIFDSVYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1D8</accession>
    <name>K1W1D8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1D8"/>
    <dbReference type="FunCoup" id="K1W1D8">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W1D8"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040204_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1D8"/>
    <dbReference type="OMA" id="YNAELWN"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="170"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="294" mass="32990" checksum="03FEFBA17AAD9529" modified="2012-11-28" version="1">MSQYQCYHTTVWKRERAVESKVESGVMGIRAVGVMQVLLIVALVRGFSTSSSVAGAPVLSASLLLSRNPLLTPSLHPFEKAYYERNFKIRHALSNPVPTDFYFKSGSLSLRRFQGSEHEMERQWYGDKLAGPAPKIGDVPPEPAHDDVPRDHWAKEDAARGEKSLERRPEEEVYLLVQSKGKWAFPGQDMKQGEALDEAISRITGTEGSLDGKTMDTWLVTRKPIGVVRDGDKRNFFLRSHILAGEPKPTKESGISSWAWLNVEEIEDRLRKQGDEKLWDGVKGMLGVAAEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1J5</accession>
    <name>K1W1J5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Importin beta-4 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02807</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1J5"/>
    <dbReference type="FunCoup" id="K1W1J5">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W1J5"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_1_1_1"/>
    <dbReference type="InParanoid" id="K1W1J5"/>
    <dbReference type="OMA" id="ANACGCV"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="336"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1062" mass="116425" checksum="0BFE83C6A0A19AF8" modified="2012-11-28" version="1">MDPAYVQQLHQLLEATIAPDTNVIKQLNTTFYKNANCIPALYEIAATSPNQAIRQLASVELRKRVSSGDGKLWKKTPEPVRLQIKQNILQRLTQENASIVRHALARAVSAIADLELTVNPPQWPDLMPGLYAAAGSSEVTHRESAIYVLFSLLDTVVDTFEAHLKNLFELFSRSLMDPESAEVRMTTLRALAKVAEYIGVDDKHDIKAFQELIVPMLKVLEKAIADDDDEGVKHGYDVFETLLILDTPLVSKHVGELVQFFLGAAANRDVDESMRCGALNVLAWIIRYKKSKVQALGLAKPIVEGLLPIGCEEDPEDIDEDSPSRLAFRCLDALSQALPPQQVFPVLSQQLQTYMSSADPSHRKAALMAFGVSVEGCSEYIRPHVDSLWSVIEGGLRDEHVVVRKAACIALGCLCEWLSEECATRHAVIVPILFDLIVDPATQKNACTCLDSYLEILGDDIVNYLPLLMERLLILLENGPVPVKITVTGAIGSAAHAAKDKFRPYFDQTITRLVQFVTLQGSDEESDLRGVATDTIGTIAEAVGSEMFRPYFRDMMKAAFEALTMDNTRLRESSFIFFGVMAQVFEGEFAENLPTCVPALVASCQQSESSDDFVDEGEANGATARQAAEAFASGVGASQIADEEEEIDETDPQPSCSMWNGARWGELFNATKSAFLPYVEETMQVLIDLLDHYYEGIRKAAVGALFQYIKTFYELSTPQEWVPGAQVKVPFHADVKKLVDHVLPHIINAWKTEDDKSVVILLCSELADTMNKCGPALVEGHLDDIATLSIEILEKKSLCQQDPDGDDEGAADADSSEYESALISNAADVFGAMSTVLGPDFAQAFGQVLPLLANYTQPKRISSERSMAVGSLGEIIVGLKGGVTQFTQPLLEIISRGLNDEEPDVRSNSAFAAGVLIQNSEQDLSQHFPALLGVLNQFFQAPEHSAPAVYNARDNAAGALARMVNKNAGALPLDQVVGLLASVMPLQFDPLENRAVYSAIFTLFRSNPAVLEPHLERLLQAFAYNLSAEHEDDTTEETRQELRALVDHLKQTIPDKVAAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6M2</accession>
    <name>K1W6M2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xylosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6M2"/>
    <dbReference type="STRING" id="1220162.K1W6M2"/>
    <dbReference type="eggNOG" id="ENOG502QV1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005484_2_0_1"/>
    <dbReference type="InParanoid" id="K1W6M2"/>
    <dbReference type="OMA" id="MAFLATH"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="4">
        <location>
            <begin position="419"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="767" mass="87889" checksum="5992FE90D794A847" modified="2012-11-28" version="1">MSRARQFLTPRVLAPVLLWTLSIWLIHTYLFELSVFPAPLWRSAGSDEAAAHRLSPEFPAPMDREGEDWIDSVDPRRRPFSPHGAPRDPFPKLRPTRFLPDHCLEEWFMTGETMCGRAELGPEDTLDATWLWVNGSDQRWADEMRLHRAKMGNELVYSMRSVVENLKGHVRTIHLILYDYAFNSTLGDLALVPQSTIDVLEETIDKSGPVYNPATRDKVLNLDGRKISERVLDHLNTKWRIVQTPTWLNFSRRDTRSPQHPVHPATGSETAAEHAHFQVPYPTLRYAGHSEIFHLPTVKRDAVTMQLGEKEWRERDWRSKALPTYNSMAIESRISWLPGLADVSIALNDDFFMLRPHAVSDFHSPFYGNVIRFKTAWFQWIKPDIDDGHITDTGEMGGLYHANYLLSARFPKRKRPYFAHAPKVITRGLHQEASLMFKEALTLSSTRRFRELRIGNGDVQIQWLLTQLRVDRWREALLWTYIVVNLGSREGLWDDASRQAIIDLFGLGVDAAQVAEVEVHRAERKTLDIFRMARIFQQAGWERPKRTTFDFTSLDGHFPGFLPKGADAKENDQCVLDFDRCFGVFWTHGTQVSASDMMKRIAFQEPDCGDCLIMALVTASGPLGLSAFFPPATSTYTNPSTDPPPDFLPPPHLPLDSTWQAVDFSLHNVLSTTSLPGQDVNLRLYCMKLLSRYIYSSGKSDVHFHMLKNAEGVKKSLKQIDDSNSVAILGLNDDIEKDYSDIRSMVNQWFHKKWPRPAIWERAWSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7I7</accession>
    <name>K1W7I7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucosamine-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucosamine acetylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoglucosamine transacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_00799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7I7"/>
    <dbReference type="STRING" id="1220162.K1W7I7"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008682_1_1_1"/>
    <dbReference type="InParanoid" id="K1W7I7"/>
    <dbReference type="OMA" id="GECRDLI"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000105">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rho-GAP" evidence="12">
        <location>
            <begin position="492"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="781"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="925"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD04853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="978" mass="109115" checksum="933A03F52D3BB639" modified="2012-11-28" version="1">MAYAYEPGLAQPRKGADQDADILKEFKRKLAEDEAYISYFNERIKIEQSYVEALNKLHAKQVGADSQVDERFASTTRKAWFEVRDYTEREIASREAFVHALQTTVVAPLTGIRDTQTRIRNRIREGLKEATEQYESYVFNKVPKLEKTYRSKEQTLEEIRKQEAAVAKQQQLLSETNPALPEKQPHPYMSAAASIRDGHSIRAPSISRSRRSSGSLDSDDPNFPSPNSPTSQSSHPPPSYHSTTPSYHTTAPSMHLAPQQQGYHPSALSPATTIPDRKTPIHFSGVQQSGRSRSGSASGLTLRDVDARSKEIMNDIAAHGKKGFRSLMDRMAGDRDGAPEKSGPEVAVSPPESNIPRRGSVRAHPVSAMKSVKARREAEEADKAYRKGVFHTETLRLRREKLQTSAIQSLTDLNEELNMNLRAALAHYVTHAHATAVTLAQATEVVGNAIKHINLEHDGMQFRSRLPPIVKNKPVVYENYHVGPCQSLIFGVSLTDYDFARGEGGDHGRPPLIVEKCIARIDAFGLETEGIYRISGRVATVRDMVQEIERTEAHFQFKPTYDVHSIAGVLKQYLRELPDPLFPLPLAERVKMTADRDSYLDNKFSVIRSRLRRLPPIHQTTLRAIIEHLARVADHAEENKMDARNLALVFNSVLFGPEKTPENGEALIQMQTHRDSVLEDMITHCDLIFGPATTPLSYHSGEYDYGAYEEQEEESEEEAPKERNTGPGTSRTKLVLVTPRDDLSDDSEPPVDKLTPDQSLSLLFDPALIPQSMQSAIPKEYHLRPLASDDFLRAHFSLLSTLSQSPALAPSTYANLFNGLKASGIYYILVLVERATDELVLSGTLLLERKFSHGGGLSGHIEDIIVSERLQGRGLGQILVRGLREMAANLGAYKVILDCQERMVPFYEKCGFAIRGRQMAHYVESQPPPRKESLAATKALGSPKKAEKAEAEVNDRRLDDIDAETEASDVTYHFPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7K3</accession>
    <name>K1W7K3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7K3"/>
    <dbReference type="STRING" id="1220162.K1W7K3"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323425_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7K3"/>
    <dbReference type="OMA" id="MERTNWH"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="406"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="771" mass="83854" checksum="9ED5EAFC74216AFA" modified="2012-11-28" version="1">METLIDLVEPDAPTAPSSTSCDDDVFTVPSAQRGEADLIVLYDDLLDLDTPPSTPPQVVKQLSSPSSPLLTLEQTLRLFEPPQLHYSPELTPVDYTDVNPHAPLVELDSCEGPAARPRPPHTAPSVPRAPSGSYTSSQSSSRPSSQPTQLSSTRVSSVSTQFAARASPLVPPVAETPAQSRPYSARPAPTQQAHIAAPLASIPSSARTARQTSIDKGKNGFAAADPHKTGPPATASPADTSPVASTARPKPRPLPPIPQVSRVAPPQTTDPAAPPPPPAAPPKKSARAARRATDSDSELTEPEGAVTEFFYAPTAAFMTELSKEAYADKAAYELYLRAPSPRTRIPLSNNYTPLEESLLRSWARAEPSLEQRKLIKDLLATLTMGLERWELKSGAASGRACERVLRVDPFGSVAWGGSTGSKGDLDLVIIDVRMVIEGMLMVDHPSLWRPDPVGNKYEVMRPIVKAKNSLYNVYYLKQKLSQIAGVTDCQAIKGATVPIVKFKYRNSIECDINVNDMGGWNNSKLILAYCELSPFVLRPLVHFLKLWAARFNLNDPSASRGPRTFSSYCLTLMAIAYLQEVGHLPNLQQGVKVPQSLDPANAYRPDTVWVNWGRQKGAAAHIWFRQKPLPGWVQEDITLGDALIGFFAFLKGSFDASSQVLSVLNGGVIKRASEKGTAEERRRLVAKQLAQLSPENASVRLADFDDMERTNWHEGMGTGKSGVQPLAWTRDALVVQDPFIWEKVGCALRPLVTFRTVQLASPPRAWTRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7L6</accession>
    <name>K1W7L6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alternative oxidase</fullName>
            <ecNumber evidence="16">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_00829</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="16"/>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7L6"/>
    <dbReference type="STRING" id="1220162.K1W7L6"/>
    <dbReference type="eggNOG" id="ENOG502QSB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041974_1_0_1"/>
    <dbReference type="InParanoid" id="K1W7L6"/>
    <dbReference type="OMA" id="IDYWRLK"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD04883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="400" mass="44674" checksum="A6334E5F262B74CE" modified="2012-11-28" version="1">MMVRPGIRLMGRMPTSTLLRASTPLPLRHLSTTIPRYEPSNALMPKTVERDEQRGPIVGTTGPGADGPHPSERIEPVATVTHDHGNWTMMNPIYTEPELDCVKVVGREPVTVGDKAAHGMVKMLRRLFDMFSGYIAKDVPASVLKENPNAIAELRKSGELLSDKDWMTRIILLESIAGVPGMVGGTLRHLRSLRLLRRDGGWIHTLLEEAENERMHLLTFLTVAQPGWFTRALVMAGQGVFYPMFFLTYLVAPKLAHRFVGALEEEAVRTYSHCINDVEKGFVPEWTDKPAPQIAIDYWRLKPNASLLDVIKAVRADEATHRFVNHSLADLDQTRDFNPFALAEAPAEIRGTKFGFTRDESAQFAVESQRKLLGQSHGGISPPKEKDEVEGQNSKKVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9C4</accession>
    <name>K1W9C4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000394">
        <property type="protein sequence ID" value="EKC98213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9C4"/>
    <dbReference type="STRING" id="1220162.K1W9C4"/>
    <dbReference type="eggNOG" id="KOG4234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736060_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9C4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="376" mass="40223" checksum="1108547D0A6381DD" modified="2012-11-28" version="1">MAATAAQPPSQPLRDPDAMDVDSEGPIGSQQSVGGSTPTSESVTTPTTPTPEAVTANQSPVSGTPLPDQPIPDGAKAPQWKTDNGPSADKPPAQSEPINIPKQTEAPKQTPKEAPKTEAPKPTPQPEAPKVDKGPVPELKDLLNNEKSLGSGLDCMSMSVSELQDLLDQATALKADGNKAFVIRPHTAATLKTAEEDYKRALGKLPNVPKHLPMPTLQDLAEKERIVEINDEEAEQIEKDQQAGPVRCNVDNEIRDAKKVLWANLGAVYVAQGRDREAVDACTRALHYDPKYQKALLRRASASEKLGTWSALTNAQRDYIALMGMLPASPLPGSADAQNLKQVEQGLKTLPAKIRAAKEKETNEATDKIGQSKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9Q3</accession>
    <name>K1W9Q3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9Q3"/>
    <dbReference type="STRING" id="1220162.K1W9Q3"/>
    <dbReference type="eggNOG" id="KOG2582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_589480_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9Q3"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="200"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="464" mass="49536" checksum="0E45DF834DA0BCD8" modified="2012-11-28" version="1">MANPPPTAGPSAQTPPPNSPPPTHAAFPTAAELGAPANVAGGSNQSQQAQQDSVNVPSTVEELHGLMMTTITPIDIEEKLVPILMTLTKLRNEHGGPDLLALDGVELDTSDSALGALSLAYTSIVTARILAKLNSGSAASEEDVTLALRLIGVSDKRQLAMCLPLAAKKANRVSDSVPYLHELLMGTSASSPRKFNGVHAALLELQPPYPTVTLPYLSVDEGTSYLDVLTYHHHAGLVAAANEDYALAAQMFSFWLHLPKDTSPAVNRMLEKTIKDYKDLAKAFEAQEWKDVQKIVQTKKSTFTQDANYGLVQQILESIPKRRILTLRPTYSRIALSDLARKVGLGDAAGAAAVKDVIGRMIATGEIRASVTGSPEIVTFEDDDDYDSPAAMKRLADAQAVASSLLAELTRADQQLGLNPKWLQKVRSIEAKEKQKEPAGKMAEGGSELRVGGAVGANQSDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBT4</accession>
    <name>K1WBT4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBT4"/>
    <dbReference type="STRING" id="1220162.K1WBT4"/>
    <dbReference type="eggNOG" id="KOG2033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300527_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBT4"/>
    <dbReference type="OMA" id="WRSYTIS"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="871" mass="93703" checksum="D963319C70A737B1" modified="2012-11-28" version="1">MSARTTPRRPSASPMSPNSQSSGSGWSPVPSRRGARSRTSQTLGGSAPSYVRRPSTLSAVHPPSSVSTASSARRKYEPANDRDWAGMEPDEVFRRLPVNEVKRVEAKMRTDALNKQTRYRDLLTSASQITALHESSLRLSTSLRTVAGACANPTELASGEMVPEQSSEGEDVATMLPVAAHMKLLIDTPEALYSYLSHHDYLSAAFLWLVARVAKDSLADMPESANRAYLPLMEKQWATLLPFRQQIVQRATAALRSRHNLDAKAGSDTLLAIILLDETPVSEALDLLLSQRLRAVREILHAPTTSKRQRRMSRVDSKHQGEDTTKAISEAVHVLLDAVTLAKSIFEKRFSAGESILVESIRLIQVGEEVPVVQTQPVAALGHHRRASRLASISLPLPPRVALGNGATPPVSAVRVIQSLPSSQILLRYLPSSVTGFTPFIPPAAAPQLKEKLGPWQSSAVDVLRETVPAWVQQLSAVSDVWSVRRSLREILSDDEVFEAQIASALESEWGSRVQEIWTTKLDTIVTSLSSKLTAAAAQVRSGQDSGLDNHCEAFMFSDIHFPAVSAGTGGTGTEHFLSSLKKRALFRTPLLDGIMGLLEDAAQDIKLDLAGLPASLYGDYREKLKSALHALVKVLDDVLADAGGHRDATGSVEAELFVGRIALYLVHASPFLPDLVGGTEVDLNRADGDPRLLPRAVAGEECLARAGAAEAAPEAAAGVVRTALSRLGPGHESPDAAQQRREAARHPAGPADDRAAGQAAFDLAFLLRLSGVSASELTTDATVSSLLDRAPSELREKLESSVEEHLRRTQLTLAPLTRHLPAIAAQTRERNAALLRLGAPQLGRASGTEFKSPIAVAKPGKRFGLLSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCM6</accession>
    <name>K1WCM6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">A1Q2_06320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCM6"/>
    <dbReference type="FunCoup" id="K1WCM6">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WCM6"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="InParanoid" id="K1WCM6"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="390"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="596" mass="63849" checksum="5C21FB3C56E2D430" modified="2012-11-28" version="1">MRRALTTAATARTLASSSRLAPAQRARPVIAATRLPAQVQVRQHSHAAPAPVVAPPVSPENTYDIVIIGGGPAGLALANALVSQPSLRDGARTLLLEGGPLDPVRNWDDQGPWSNRVSSLTAENIAWIDSEYSLQKHGELTGGIGAWKHIAQDRSREVDDIIVWANPDADSTPMLHFPGPDLARMTENVNLQRALLRHLDEVKQTKGHKLEIREKTRVGDIAYTAGRGSVALNLGGEWVQASLLIGADGPNSPARKFAQIDTFGHGYNAHGVVATLETQRDVYGNHTAFQRFLPTGPIAYLPLGDETTTMVWSTTPEIAAALKALSPEALTEMVNAAFSLSENELKLLTEAVLTAHNDQSAMSAEGIRSIMALFERRVSDAPRPPLVRSVDPKSVASFPLKLAHADKYIDHRVALVGDAAHTTHPLAGQGLNAGLADGQALAKVLEEARRVGSDLGGITALAQYPRDRYLTNHILLAAVDKLNSVFGARNPLINWARANGLEVFNELGPIKDFFMRNAGSGIAGKRTQQQREFGRARAEDKLNAKAAGAPAALADAVEGLDMARRVASSAGGVIAEGLKNLLRRGADSIEHQQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDL2</accession>
    <name>K1WDL2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDL2"/>
    <dbReference type="eggNOG" id="ENOG502TKKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572396_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDL2"/>
    <dbReference type="OMA" id="QENHRAY"/>
    <dbReference type="OrthoDB" id="2595104at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="397" mass="42976" checksum="4897411CB64A1D58" modified="2012-11-28" version="1">MFEEDFERCFICQQPCKGLYCSAECKQQDNGTPSPAIKPAHGIHLTAQLPSSLSPRVRPVHQIAPSPIFSPRRRGGSSSSSSISESPIQSPATNPVDGGSPNKECFNLPPPAYPTQVFGSLSTMPVKIPSSSRTPVMMTVPLAGTTAPSGTSVETLRFGRKSSVTNSVTSPLALLPRCGCGRPIGHRARSRDRSDAAEAISCLSLGPNNDEVRSSASRVCSDSSRNQGTRTPNILCPALPEERSITHVLGSSLLSRSRSDPHPPSPRASMGGIHPRPALELSGVAAPMNHSPLPPVTSAMPNMTLPNTGRETRGRSRERVARPDRQPVSKLTHHEEREVAPSRLDRNSRERSRERNSRERGRMAHSRSRSRPARRSGELALGLSYEDRGRLRPQVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFI9</accession>
    <name>K1WFI9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-vacuolar targeting-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFI9"/>
    <dbReference type="FunCoup" id="K1WFI9">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WFI9"/>
    <dbReference type="eggNOG" id="KOG0680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="InParanoid" id="K1WFI9"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="450" mass="50595" checksum="E329AF7BD91F953C" modified="2012-11-28" version="1">MPTPVLVLDNGAYTIKAGVVGQDGDPRLFPNAVVRSRTDRRVYVSDEIEQCRDLSGIAYRRAFERIQPSDTSLLVTEPYFNLPNIQETYDQMVFEEWEFDSYYRCTRMFSNETDIPPECMIVIDAGYSFTHVVPIQGGEVVWEHVKREAPDKSPEAPHLIPAVEHVGPDARREHGARGVRIRLDGLAQRPREVQEYVLPNFSSKPYARTGYIRSGPNALSAAELEEAEPSEKPESKTKRKVPGDDDEEQVLFMGNERFAGPELLFHPDHIGIQQMGLPETVAYVISCMPEELQGMYWAHIGVVGGLGNIDALGERLERDLRALCPVDYDIGIYEVFEPVSAPYQAAVSLASNDVYLTNYPVTRAEYQEHGSTICRRKFGGPAYNVSPPGFSRTDEEPVDEHEQELRYALGLDSIKGRGKRKGEEEEVTSGNWGGRRRRAQESGLVSGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFJ9</accession>
    <name>K1WFJ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFJ9"/>
    <dbReference type="STRING" id="1220162.K1WFJ9"/>
    <dbReference type="eggNOG" id="KOG0542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696743_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFJ9"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43396" checksum="7D29E23BD03F8D17" modified="2012-11-28" version="1">MLKRIWSRQSEPPVPPVPPDTPTSIHTSTAVEPVSSETTPTVETGPEDEGAPAEEVPAEGEGEDGEEGERDEDKSRGMKRPSKRATAAEMRGELARLGLESKGKRETLYRRISAISALTWRGHAREARGSTIRTRLFRVVTMGRGRFRVWRKDAQTSDSGHVPLIRSADVAAETERVLHKLDGDTAGELLVLLPTLADREATVDAAPTFPQVLVRFEHWLDSWGLRDDGGGLRGAMWVTDGPWDLRDFVPKQLHITPTPSYPAYFQGRYLNVKNAVATYLADRDKGLRVTTGRVIRAPKDRDGPRALNIPGMLDVMGLGRFDGRQHSGIDLTPGRKQHCPHRHGPSGPGRAHRAECAPAHPQEGAEMGLDGRPGPGDLGRAAGPIRWRGHEAEDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG75</accession>
    <name>K1WG75_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05194</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG75"/>
    <dbReference type="FunCoup" id="K1WG75">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WG75"/>
    <dbReference type="eggNOG" id="KOG2851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028288_3_2_1"/>
    <dbReference type="InParanoid" id="K1WG75"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="438" mass="50316" checksum="99DBCC46DA6290F4" modified="2012-11-28" version="1">MAVTDPSSREVMRAFYKRLFPYKAVYRWLNQGDVPGKLWTHREFAFTIENDVYIRYQSFSTAYDFQKEVLRLLPSRFEIGPQYSAKPRDRKTLPAGALQPERRELVFDIDMTDYDEIRTCCSDKAICARCWGFIAAAVKVLDKALRETFGFKHLLWVYSGRRGIHCWISDTLAMDLTDDQRRALTMFLEVIKGGKEQVKKVNVRGLGDADLHPSLKEALQTLKYEFSRLILEDQECFRSERGWHTLLELLPADREVKDALRAEWESQPDASSTTRWEQLMAHMPRKGTPAYRKYKNAIEDVILQYTYPRIDAEVSKHRNHLLKSPFCVHPGTGRVCVPVDPERAHEFDPATVPSVGQLLRELDTAAEMKTEEGDGSGATGEVKPASKLASEWEKTSLKPYVEMLESHARSIVADLSEKRRAGEEGRDAKRVKSESIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGZ0</accession>
    <name>K1WGZ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGZ0"/>
    <dbReference type="HOGENOM" id="CLU_1826648_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGZ0"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15586" checksum="6F822855C8174A93" modified="2012-11-28" version="1">MPAVRKTKKTPKAAKPYVKTEQGAEAKIEEGMSKADVRNGTYDRIQMFSDIIRLAKKLGKTADHGREWSNSGSAAWSTKAKIEVLVTVLKVFSVLRIPADAQGINPDWTHVAAAQGRTPTQVKDVWRKVMQPKLLKGETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHU1</accession>
    <name>K1WHU1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">A1Q2_04706</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHU1"/>
    <dbReference type="STRING" id="1220162.K1WHU1"/>
    <dbReference type="eggNOG" id="KOG0317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041707_1_1_1"/>
    <dbReference type="InParanoid" id="K1WHU1"/>
    <dbReference type="OMA" id="REKSECP"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000671">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="273"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EKD01019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="36266" checksum="0D9347A67DFACD47" modified="2012-11-28" version="1">MDSTRAVAANVPHATPSQPLTRASPPDPYDRLQPDPASQAQILRSYQRDATQVSRLTELVSELLRSAAGTRWLAHRQMIVDLAVRAAYLLLTFGRGKQTLGEEYTDILPMRRRTKQLPSRSGQPGDDSFAARVKARLAKFLESPLGQSLPEIHLVLFMFRGTFYEAARRFTGLTYISDLPPRRPENRAPSYEPLGLIMALPLLYRLFPKFRSSSSSAPRAAIPAGILPKEKTDAGPIPVSGPNNSVVVTPGTNYDAPNTYLTIEAQELPERQCTLCLEPRGSGEGSGGTVAVTECGHIFCWGCLGGLDKMECPLCRQALRMERLVAAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WII9</accession>
    <name>K1WII9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WII9"/>
    <dbReference type="HOGENOM" id="CLU_1300462_0_0_1"/>
    <dbReference type="InParanoid" id="K1WII9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012497547" evidence="1">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="212" mass="23223" checksum="5F3E818DA86F1178" modified="2012-11-28" version="1">MKAAIILAALASVSANPTSIGKYPFSPALTVGYEPNLASPSCFSSLESASASIKRASDGHGFAHFDDWGVLTSYDSAGHAVQHAVVSWPATVAYFESLGKWDAFAKTGHLGEICSRNLTDDVHERIRRAREEKKEQGEEAWPKVPFECREKIPASNINREGRQLKPYVPPQATRQVQMWCLNTPCSRDSDCSSQGCGTCIMRDKFMFLSCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WK10</accession>
    <name>K1WK10_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WK10"/>
    <dbReference type="STRING" id="1220162.K1WK10"/>
    <dbReference type="eggNOG" id="ENOG502RUKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047725_0_1_1"/>
    <dbReference type="InParanoid" id="K1WK10"/>
    <dbReference type="OMA" id="PYVHSCT"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="36930" checksum="E0E2B2B9F9A118A0" modified="2012-11-28" version="1">MTRCHPYTLEDICIDAKAPQEEINALIGKMGAIVLKGLLSKEEVDQMLSDFQPHLDALGPSGNREQWDGSFFPPTSKKVPGLLGKSDAYVHSMALNPVLNGIADHALTRRTKTTMSNPERYWSTCRPQLNVTGVLEVNPGGKAQDLHRDDAIYHDPIRGSDVWDPKQEKSILALAALTPVTPENGGTLIVPGSHIRSDDLPPPTYEDAISVRADPGDCVVILCSVYHAGGANKLEVGAPNSIRTLALCGWSCGYLKQEENQYLQLTKEEVMRLPVAAQRLAGWEVSLPYLGYVNWEHPLLTLGHPRSKVPQLDDLFYDKDQSDERKPYLPSVISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMR3</accession>
    <name>K1WMR3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMR3"/>
    <dbReference type="STRING" id="1220162.K1WMR3"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_3_1_1"/>
    <dbReference type="InParanoid" id="K1WMR3"/>
    <dbReference type="OMA" id="IWVGMDE"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="405" mass="43081" checksum="A80E53AF54D0A906" modified="2012-11-28" version="1">MSAPAPTVDSIPASHEPIKAALLGGGLFATNSYVPSLALVPGLSVSTIWSRSPESASKLAAKAKETGLPNSPSPEVKSGPDGLDAILADDSIRAIIMVLPLGVQPELIRRAWKAGKHVISEKPVGRDVEQASQLVEEYEREWAPKGLVWRVAENFAHEPFLHRAARLLASPQVGPVVYYRMNFETVLLDGASYHATTWRTVPDYQGGFLLDGGVHWAAVLRCVLPPAYLPTTITAHKALHRSHMPPHDTLVGLALPSPSATGEPQGSFAPGAGTMDLKDMPVQPGRSAPVGSFTLSWALPDTARESRAQNELRVTCAHATLTLINKGRSWRLELRGEEGGEVADVTEEGPVSGVARELAEFAAAIAGENGVNNGEPRAALWDVGFVEAALESDGKPREIGVKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNU7</accession>
    <name>K1WNU7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNU7"/>
    <dbReference type="FunCoup" id="K1WNU7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WNU7"/>
    <dbReference type="eggNOG" id="KOG4100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102310_1_0_1"/>
    <dbReference type="InParanoid" id="K1WNU7"/>
    <dbReference type="OMA" id="WQQTNEN"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="153" mass="17256" checksum="E16E408AEC302C34" modified="2012-11-28" version="1">MFRTAVRLAESGRVPLSLSQASAELLPPIPLYRRLLRAHRSLPAEMRFMGDAYVKSEFHATKGTDNPLHIMAFLGQWKMYLDQIEAQLNEGKPFDGRKLDPEIMNSLNNEQVGQLYELMHSTDDLWKTPEELEAAAAEAEAADAAERAAEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTM1</accession>
    <name>K1WTM1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTM1"/>
    <dbReference type="FunCoup" id="K1WTM1">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WTM1"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="InParanoid" id="K1WTM1"/>
    <dbReference type="OMA" id="RDQRMHK"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26823" checksum="9F329CAB23826C13" modified="2012-11-28" version="1">MSAKRPSPVLPNAMPWPIFEKLRDKRVVLASGSPRRKDILENVGFRPEIIPSTFAEDLPKGSFDKLSDYPIATAGEKVYILAGFSELTSGDGGLRAPDSRERCGPRRHPDTVVIFPPEKDTAEGGKYHGEHSEILEKPINKEEQLRALDLMAGRECEVVTAVCVGESFYPHSQLTSVYPTVESPGFKLQSISVSTIVHFFDYPKNVIQAYIDNGEGIDRAGGFAIQGLGGLLIEKIDGSYDNCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVW0</accession>
    <name>K1WVW0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVW0"/>
    <dbReference type="STRING" id="1220162.K1WVW0"/>
    <dbReference type="eggNOG" id="ENOG502S3WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718023_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVW0"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="385" mass="41793" checksum="D60CAB06D5BF488A" modified="2012-11-28" version="1">MKLGRLNLHFGSSRKSKTENLHQGSPPSQPSSSSPRTSTRSRSSSTSNRHAGQSPPPPQAPTSASPRRHPGLYSSPSARAMAPTAIVIPLYIYPSPSAWDPLIRTAKANPLVPFVAIVNPNNGPGNTVLPDACYQSALAELCTIPNITLLGYVHCVWCKRDSPEIESDIDTYACWAAESQGRFGVAGIFIDEAPWDPCHRAYMSNLAQYIRKTFEEETGTPGLVCYNPGVVVDQGYLEDCDLAVVFEQSHKEWYAYFLRKGLVQIPYNLRSKCVAMVHSFGQLEGLEPTSPTSPHSSNSPNSPNHRNGNGHGHGHGRHGSIELDGSHAGGVAKAAIAVTDQITQLGFGGVFLTEQVGGYSHFPETWDTVAERLTQTQTQARSTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWU4</accession>
    <name>K1WWU4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000141">
        <property type="protein sequence ID" value="EKD05169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWU4"/>
    <dbReference type="eggNOG" id="KOG4188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067132_0_1_1"/>
    <dbReference type="InParanoid" id="K1WWU4"/>
    <dbReference type="OMA" id="NKAADFG"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="236"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="379" mass="41147" checksum="59EC5B52E7A1D846" modified="2012-11-28" version="1">MPIGPQLPPHLQRHVDSPATDDDSGNAVEQDQDQDFGPSLPPHLAKMRQQKMQAEVGPSLPSGSSRSRSRTPPGERGERSPSRKSGRSPSRSDQIGPSRAVGPQAPPRQAGPQLPRAAGSRSPTRTVGPSRPEPVGSSRAPGPARGPVGPIGPPRPGQGDESVNPTVRPARTPVLPENDDSSDDEVGPKLSDFVDASAAPEKSAAELFREREARMAAAPKPEEKKVTQRDEWMLAPPTGGSLASLDPRKRPTTFQKSAKADTDLDGQREWTETPAEREKRLREGGSSRSRPEDLDRKRARERDDAIRQGVQQHATSRGPSLMEQHKAKKSKTDEPEVIWDRDSMLGVGGMLSEEQREKKIKEARNLGDRFGHGKSGAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXW2</accession>
    <name>K1WXW2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXW2"/>
    <dbReference type="HOGENOM" id="CLU_903689_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXW2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="308" mass="34960" checksum="6B43BE7A2E233486" modified="2012-11-28" version="1">MVTSTSSEHADPFKQWKGASAFAHKNATISLKVQRFSPRGKAEETTALIVRPPSSTSLSAKLHDKIVGPPFVYTHFRWLEDGRWKAINRVDLCTAYFRLCNDYDGLWRALQGLERLATDNDAVSVGRELEGRSRFKSEFHVIRERGERLLPRLKWAVGHMAEYLEILDRCEAHNVHPPRKGAWAVYPDPVTAETVRLPEKETHMRLFRNGNLDDYAFRAAKVINKTDTPEVVRVLREEIERVARDMLEFKGCKDRETVWEYLPMKGGLPPPSLVVSTEPIADIKGVIEKLEAIPEAEGESSAPPAYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V053</accession>
    <name>K1V053_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA processing-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1V053">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V053"/>
    <dbReference type="eggNOG" id="KOG1070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000845_0_1_1"/>
    <dbReference type="InParanoid" id="K1V053"/>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05696">
        <property type="entry name" value="S1_Rrp5_repeat_hs4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000727">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000289">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000340">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.162, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="120"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="246"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="334"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="434"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="525"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="614"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="698"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="795"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="887"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1459"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1115"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1459"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1499" mass="163096" checksum="DA1BCA1E2BD1B410" modified="2012-11-28" version="1">MAPSKKRQQPGNDSPAVKKPRTEARPAPAFTSALQSEEVDFPRGGGTSLTALEVKQTRAEGARQADAEMGKTLKKKKLSTRQMQKAKKEKATAESDAAKAERDKDTIRVEELSYKRLVPGTLVLARVHTVLPLHLVVSMPNNLLGHIPITEVSNTLTAALNADIDAMSEDEDEEDEEKEGAPELTDIFRPGQYIPTRVINTFPTASQAFIAQYPVSETTRLAARVELTAVPEKINLDVAKQDVEKGYRIVGEVLGAEDKGYRVGLGLSADTGLAGVEGFIPIEEVEKNAGGALIPGQLIPTVVSEVKAGGRVVKLTLDPQTLIHSSLTEVSNIGSLLPGQLASCLVTAVVPSGLNVKICGFYDGTIDIAHLGLGEDDIEDRYNIGKKIKARILYDTVASSERRFALSALPHIFNLASPVAADGETPLEIAIPVGKTLPSVKVIRVIPDWGVVCRTDDGLEGFTHISHLSDERVPTLSNSTGQFKVGTYHRARVIGHSPLDGVMLLSFEEKVLNQVFMQVGELTIGQVLKGTVRKLSDKGLFVNVQGNVDGVVWPLHYADIRLKHPEKRFKVGASVKARVFAIEPARNRVVLTLKKSLVESDLPVPGSFADVTAGEITPAVVSKILDKGCIVDLFGGLRAFVPQSEASTNYVANLNDVFFVGKAVNVRITDVDEHSQKLVASVRQALPTAVAAEKLEVGSDVSGIVAQIHAEQVVVTLIPSQLTALLSLANLSNHRGMGVDELRKSLKVGEKLEDLVVVSKNATSGLIIVANKRAKKGIPTGISTPARNFDAIAVGDVLPGRVISKTPQGAMVRLGKKIRGRVAPTDASDDLSAPGLKVDDDVLCCVLKVDAESRAIDLSTRKSRVQPDSAPAIVDAEINSTADLKAGQSVRGIVKNVAPNGLFVALGRSVTARVMIKELFDDFVKDWKARFAVGDVVSGKILSVGDDRVEMTLRTKPRKAGAETKLTLADFKEGQKVEATVKRVESFGLFLRIDGSDVSGLCHRSEISDNKKQDVSQALKGFREKDHVRAVITSIDKEKGKINFSIKASHFSDDFGDKASDEEEKESGDEEEEEEDGDDESMEQDDESFVMPKLLGDSDDESPDMLKLYSADAEMPSDDEEEDDDEDEDEEPSEDEEEIDTAPTEDTPGAQKRVSTAGGSTALSLSGFDWNGNAAESDSSDSDSESDEEAAAPKKSSKKKTDLTAAEASGVPQSASDFERALLASPNSSFLWIQYMSFQLQLHEIEKARSIGRQALDRIAFREEGEKLNVWMALVNLELGFGTPESTDKVLKQAAQYNDAREVYMRYVDALVQAGKDTPEVLDEVFKRLLKKYSAFPQSWLKAAEASFRRGDVEGARSLLSRALQSLDKAKHVQMLEQFALLELKYGQAERAKTLFEQLVSRYPKRLDVWNVYVDQLTKLGDIAAARNLIQGALGRKLTMKRAKFIFKKWLAVENKIGDRKGQENAKEKAREWVAAHTAPADGEDSDEEEEEEEESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V099</accession>
    <name>K1V099_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000413">
        <property type="protein sequence ID" value="EKC97334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V099"/>
    <dbReference type="HOGENOM" id="CLU_834679_0_0_1"/>
    <dbReference type="InParanoid" id="K1V099"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="333" mass="37003" checksum="A379646D06778065" modified="2012-11-28" version="1">MRDSFRAILAENKRLLRDISVLGEQLRTAHANVGQLQEANASLKRECARLAIERDDARRRWRETAVTQAQTHAKYYVLGTRQASLHRLLDDVLPIAAQKAMETAAKGDHERRCKFENCHVIWVLGANSVEQKLERFKDLMRDMGPRRPLSRRAQDALQDAAAQRNAHAHPARAALEFLLSCLRRGTGINELCDVVEGLLDNADDLATSTASLDVLIDCLPARVASCIPISAEDAESANGTAHRVTDLGWIPPSLRSLDGERLLRLVDTAPDADLTSAASADRDQCAPSTDQLGDIPMVTMPDFEPQRPGRRAKSSDRWDRHPDGTWARLTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V182</accession>
    <name>K1V182_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60s ribosomal protein l21-a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V182"/>
    <dbReference type="FunCoup" id="K1V182">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V182"/>
    <dbReference type="eggNOG" id="KOG1732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_0_1_1"/>
    <dbReference type="InParanoid" id="K1V182"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="160" mass="18206" checksum="0D0227EF14E51CBE" modified="2012-11-28" version="1">MPHSFGTRARTRHMFKRQFRQHGAPSLNVYLTTYKVGDIVDIVANSYQQKGMPHKFYHGKTGIVFNVAPRAVGVICYKVVNGRYMEKRVNVRIEHVKHSKCRQEFLDRVKSNAAAKKEAKAKGEVVVLKRLPAQPREARTVSTKNNTPQTLAALPYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1F4</accession>
    <name>K1V1F4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1F4"/>
    <dbReference type="FunCoup" id="K1V1F4">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V1F4"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_0_1"/>
    <dbReference type="InParanoid" id="K1V1F4"/>
    <dbReference type="OMA" id="HTMSKRT"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="3"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC97749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="632" mass="69372" checksum="8846CAFABA6756DC" modified="2012-11-28" version="1">MALCISYYLQIKRIRAVHETVISIFAGMIVGIVVRLSPGHVIRDMMSFKHTVFFNLLLPPIILNSGYELKQNFFRNFGVILTLTVSVLVYIWGLLGLEGLKFSLLECLIFGSTLSATDPVTILAIFNTAKVDPKLYSIIFGESILNDAVSIVMYETLSHFHGGDDIYLSSLFHGVGIFLFSFFSSMLLGVAFGLVCSLGLKHSHLATYPQIESCLVALCAYTAYFFSNGLSLSGIVSLLFCGITLKHYAYHTMSKRTQRTTKYMFAVLAQLSENFIFIYLGLNLFIQDVQVFKPLFIVVSAIAVMASRYAAVFPLSELINWFFYTRGQRYEELPHSYQMMLFWAGLRGAVGVALAAGIEGENAEALRTTVLVVVVLTVCIFGGTTARMLEVLGIRVGVEDDDASSDEEEEGWTHGGNISLQNTRRYALQNGMYGDDDDGGYNTTPIDSPYISSGINIGNQRRSLSRGAMSRAGFSTNSEDSDEEPLPQGYGDRGDVEAGHAGERQGMIFRDGQWFTSLDERYLLPLFSNSVTARRHHAKKARKGRASSGAYNGGESGSGTPLGGSSLELTREEYSYDGGSENGKGKPTRNFSGTVSEFFFARAEPSSSQNQSPTEASSRKGREGSRDRGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3H7</accession>
    <name>K1V3H7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000388">
        <property type="protein sequence ID" value="EKC98504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3H7"/>
    <dbReference type="STRING" id="1220162.K1V3H7"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597184_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3H7"/>
    <dbReference type="OMA" id="WEGHESE"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="450" mass="49497" checksum="769604F927015C5D" modified="2012-11-28" version="1">MAPPPPLDAPRSKSGPVQTSYEEKLQLYSLYKQATDGDIAVPRPGMLDMLGRAKWDSWNKQKGVDQKDAKRLYVSTLQKVLERFKDRAPEARRYIIELESMAPERPLSRASSTSSFHSSRASLPPGQDEDDLPGMDGTDEGPSQQRYPPPDPSLPAPDVAPNIIPPSALNPSHRSLVNSPYSAPASEGFAAPSQQFLPSRPQSILSGITPANPRRPGAPGPGGVGGGLEFVPEQSPTNPPNMQGPHPSQPPPPSAQFISRDFGTPDFGFGRGSVPPMIPEYRSGSAAEFRSPYVSQSPFPRPASASTFSHAPLNLPATLQQIQTSLQALHERMSALERSQAVVLRRQDRRKSWFWTNADDELEEAEFQSERDRWRSAPSTTVRTRNSRRRGLTMRVVWALITAVRRAALATGGIVLVAAIVISLMRGSMRRNLALQWKRTRARLVHMLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7Q4</accession>
    <name>K1V7Q4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_05683</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7Q4"/>
    <dbReference type="STRING" id="1220162.K1V7Q4"/>
    <dbReference type="eggNOG" id="ENOG502S50Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083984_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7Q4"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853612" description="Cytochrome b561 domain-containing protein" evidence="13">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="14">
        <location>
            <begin position="77"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD00025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="289" mass="31072" checksum="CF6112B8FD64A5E7" modified="2012-11-28" version="1">MSTATQIRCLLFLLSVLALSVHAQYGEYGGNGGIARPSTTLTRSPLATISAWRAGASGEAGEYGSNVVVSSHSATVAHVVCGALATMFFLPAGVLLARSRMPFWFPVHAVWQFLLSLGFVCAAFGIAWAHFSGGLDSPHRRAATALFTLVIAQALLGVCAHFLGRRMTHLKTRTGRSALHFFHWFLGFVVIGLGWAVAYLGLSSEWEKRGHGHVSGGWKAGWGVVLGIWITLYVIGLGFLPLQIKKERERVAPRAQGPEMAETGETAAMVGPAPEPGYPKMSYETRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8M2</accession>
    <name>K1V8M2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8M2"/>
    <dbReference type="FunCoup" id="K1V8M2">
        <property type="interactions" value="633"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8M2"/>
    <dbReference type="eggNOG" id="KOG0526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="InParanoid" id="K1V8M2"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="333"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="550" mass="60988" checksum="C8BBB152F192A92B" modified="2012-11-28" version="1">MSHVTFDNIFIGDSSELGKLRFNPAGFGWKSYKDENNTPTTFNGADVRGAVWMRVARNFQLRLSMRTPDQPRVTFDGFKRELTPDNDLAFEVQHKTAFELPLSQVANSNIAGKNEVSIEFMPKTFEGNSARDPDELVEIRFYVPGKSKKPKGSDAGSDEEPETDVDEEGNEISAAEAMHNMIKDKADIGAAVGDSIVVFEEVLVLTPRGRFSLEFFHESLRLLGKSTDYRVPFSSINRIFLLPKLDDLHIQLVLGLDPPIRQGATRYPFLVAQWPKDEEVDAELNLDDEEIAKYPDLQKKYEAPTFQVISRVLKSLTGKKVTPPGNFRNAQGVNGIKANVKAVQGELYFLEKGLIFIAKQPILIDFSKTESISFSRVGGGVASARTFDMRVTSKTGTVPTVFSAISKEEAGPISQFLASKNVRLKNEIDDVMDVDAVMDLDSDDDDDVSINSEDEGRKKKKKGDKAAVRRPVDDDDESEDEDFMEESSDGGSPSESDSDDEDSGFASDASDPMMEELRKKQEAKANKKKKKAADSDGEGPSKKKSKMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8Z9</accession>
    <name>K1V8Z9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8Z9"/>
    <dbReference type="STRING" id="1220162.K1V8Z9"/>
    <dbReference type="eggNOG" id="ENOG502S7M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1054440_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8Z9"/>
    <dbReference type="OMA" id="MYRWIST"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="112"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="264" mass="29731" checksum="3F1AF4E862A5F7FF" modified="2012-11-28" version="1">MPAAVSSAARRAKRVIESDSESPEEEMELDDAKRQAAKKAAKRTREADNADADSDDEFREDESRATSPSKMTARQRAKREKEMGEDEGLIDEGLMSLPDGQVKVKPILTEAERLQKREEMARRRKRQNEQRLQDEQDQTINRLLRAQTGRSRSKLDHTPLPDGESGASSPTKQRSVLDIPNGIRWVSRLDGENVTMAVSVMEGNEKWLDFPERPPREAGEKKDKDEAAKCAAKGCNEKRKYRSTKKFDVGGCSLPHLKEVEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAD7</accession>
    <name>K1VAD7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_08007</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAD7"/>
    <dbReference type="FunCoup" id="K1VAD7">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAD7"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_0_1_1"/>
    <dbReference type="InParanoid" id="K1VAD7"/>
    <dbReference type="OMA" id="NVNAYMR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="589"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC97695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="815" mass="93173" checksum="34F1EF1451F51878" modified="2012-11-28" version="1">MKFGRRIKGSRYSEWADQYVDYSALKKQIKNNLPWTDTAEAEFIVSLRKELEKCETFQRTKAEEINSRIDSLEKEVVSLVAKAAAADSSDDDSSHHHQDHRTPRDTEAAVNSYRDDDGGSDDDDVGDDEEDDHISLDEIEERFKELEEEVAVLVADVHDLALFTKLNFTGFIKIVKKHDKLTGFALKPTFNKDFLEQHPFYKMNYDPVIVKLSKLFDLVRTRGHPVEGDSSAGGNQNAFVRSTTKYWVHEENIVPLKLNILKHLPVLVFDTKKEFNVKDSAITSIYYDNEELELYLGRLEKTEGAEAIRMRWYGDVDGKVVFVERKTHREDWTGEKSVKERFTIKEDKLNDFCAGRYTMDEEFDALVKKGKKTEKEVEGMKQLADEIQYAIVTRNLRPVMRSFYNRTAFQLPGNATVRISLDTELTLVREDNFDGNDRTHGNWRRTDFGIDYPFPTVKKEDKEIFPYGILEVKLATRVGEEPPQWIRDLVNSHLVEAVPKFSKFIHGCATLLPERVDLVPFWLPQMDQDIRKPVSSRSRVLIERPTSVPTSGEHSNAGESPVIDASTGYNEPVSEGEEDEYLVNTAAEHDEDRLLRLPPEAQADAKAAREHRERKLRENGKADDSGFQRPTGKGQYDRALRVDPLTPSNRFDLNVSAVDAKLAQAERDTREDAEEAQLEADEDDDPAVTLTREFRAPPGKRIAIPVRIEPKVIFAAERTFLKWMNFAVLLSMVSIALMNFISADDSVGIIASACFTFSALLATAYSGYMYVLRILRIRDRRAINYHDKWGPTFLCFTVIASVVINLVLRVLFDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBT6</accession>
    <name>K1VBT6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBT6"/>
    <dbReference type="FunCoup" id="K1VBT6">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBT6"/>
    <dbReference type="eggNOG" id="KOG0964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_5_0_1"/>
    <dbReference type="InParanoid" id="K1VBT6"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="373"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="174"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="257"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="538"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="829"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1058" mass="121464" checksum="8393EFA20C529B76" modified="2012-11-28" version="1">MSDKERLNLLKEVAGTKVYEQKRAESVRIMEETDGKRAKINDLLDTIEERLEELEGEKDELKQYQESDRDRRCLEYALFNQELKEVTDKLEQIEDERSNDVHDSNERRKEFNDLENKIQRVEEKLTESKHSLATTQISHKQDEAERADLVRNKAEVECVIADFEQAGENNETRRLELAEQLDNIDKRVAKASEDFMGVSVQYETNLALERQEKEKLETTQSKLQVLFAKQGRARQFASQADRDQFLNKQIQSLQAFEQQQQKTIADLQRDVANAKASLDEISKRAQDQLQGEEERREHLKQMSEEAAKLKVELDGMQEKRKELWREDGKLSQSAHNAKGELETAERSLQSMMDKDTAMGLRSVKAITKRLNLQGVYGPLYELFDVSDKYKTAVETVAGGSLFHVVVDTDETAATLIKIMNQDKSGRVTFMPLNRLKSSNVQYPKSNDAVPMIQKLRFDRMYTMAFEQVFGRTIICDDLTVAAQYTRSHALNAVTDEGDRVDRKGALTGGYHDVRRSRLDAVRKVKHWQKSYETDADRHKEVKESLITLEQEISQAMGKIQKFEARRKAILDDRSNQARQANWTQREEETARQRVTRLEGTLSDAEAQLRGAATQRTALQDELKTPLQQQLSPQEVQELEVLSQQAEALKEALLQASNARQASWADRSQLEIELTENLRRRREEIRSKLDDLEGAAGAGVLQSGEVELRKSELSTINRSIAELDKRLNSTEKEIEKVQSEINDLSIKLEDLQARQMDSTRAIVRAQKSAERYLAKRQMLVNRRDECNTQIRDLGVLPEEAFSKYRDAPPAKILKKLNKVTETLKQFAHVNKKAFEQYQSFTKQRDELLQRREEMDESAQSIKELIETLDQRKDEAIERTFKQVSAYFEDVFEQLVPAGKGQLIMQKKQDGGAAFDETLDSTAEGGEKSEIDNYTGVSIRVSFNSKQDEGLLIQQLSGGQKSLVALATVFAIQKCDPAPFYLFDEIDANLDPQYRTAVANMIHQLSDSAQFITTTFRPEMLQFADKFYGVFFDKQKVSDIKTISQEEAYQFIETAAELRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCU0</accession>
    <name>K1VCU0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCU0"/>
    <dbReference type="STRING" id="1220162.K1VCU0"/>
    <dbReference type="eggNOG" id="ENOG502R2FK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994627_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCU0"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="280" mass="31099" checksum="DA98DA23E238FF29" modified="2012-11-28" version="1">MASLLRGSVSGASRLCSTSCLRQLSTAAGSAAGQFSSHSTTPSSTTVGTRGSLPETSASAALTRSYSDYSRRSYRDDRPRRPREERQGRWDNDRSHDERRFDYRGPQSRGPPRDPRARWADRDRDQSGRPDRSPSLSRPLRGADDPAPSSEPSSSTPKRRWNPTKKLTHATMSAIRELHRQDPEQWSKPALSKQFGVSYEAIGRILKSNWREKEAAKAAPASTAAMAAMKGGSMAAPGKWSLGDEEGMTIAETTDPAAFVRKAYEMKRKLEAERREEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCX8</accession>
    <name>K1VCX8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCX8"/>
    <dbReference type="FunCoup" id="K1VCX8">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VCX8"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="InParanoid" id="K1VCX8"/>
    <dbReference type="OMA" id="RVMAMEF"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="197"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="653" mass="73186" checksum="B877D4F6F0ECED64" modified="2012-11-28" version="1">MSYRLAARSATRLRPSTLVTGQAARLPRVCAALHPPPRTVTRPPRLQPASFARYKSSSATSHEQQNESSSKSPRTKRLAKLLAVLIALIALYNYYPPFRHSTLAIVRCSRLMSAVLQDVWDYKRTFAKESKLCDNEGNPLDGNKDIIRQARKACHTRSAERILKALKKNSGIYVKIGQHVAAVQVLPKEWTSTLTPLQDQCTPTPVEDIDAMLRTDLGLGIDDLFIDFDPTPIGVASLAQVHRAVDRKTGQPVAVKVQHADLQEFAQVDLATVNFAISFVKLVFPEFEFGWLGEEMNEMLPQETNFRHEAANSLHCRRNFEPLSGKTSLYLPKVLWAERRCLVMEFINGARIDDLAYLKKHHIDRNQVSQELSRIFSKMVYLDGFFHADPHHGNLLVRPKARDSTSPFNFDVCLLDHGQYFDIPPDLRVNYARFWLSLMTPNSEETSKQRKKYARLVGNIDDDMVSDVRNSTDQQYPFLESAITGRVSMEEGHHRGEDGQGPRSLLEGAESGSKEVAKLRAAAMDTEGLLAGIFQMLRTVPRFLTSNGLWTSVWQQHMDPIESTSSSDNTVPKQSDCEHLYKELCEDGFSFGLLRSALKVLFDFAYYRTMFGAAELGMDVAARVKKAELWFHGLVEGGLKGASNEAAGLGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCX9</accession>
    <name>K1VCX9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCX9"/>
    <dbReference type="STRING" id="1220162.K1VCX9"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="K1VCX9"/>
    <dbReference type="OMA" id="DFVTYPF"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="432" mass="46093" checksum="70CF87FC6BAD0529" modified="2012-11-28" version="1">MKTRISNSFFIGQIVGMLVFGALIDRIGRKFGVVLTTCALIGGIVISCAAHGTSELGMFWMMLVGRGLAGVGAGGEYPVCGTSSIEAADETSTVRKHRGFLVASVGDFAIDFGFVLAGIVVIIVLQCYGYGLHSTGTHGFEGTWRICLGLGLIPPLAVFWARLKMVNSTAYRNAAMKGMLGVRVYWLAFKRYYPRIIGTCLTWFLYDAVSYPFSLFSSQIMSQVNPQNSIVQNIGWSTLINAFLLPGCLIGGYLMDKIGRKQTMALGFAMQGILGFGLGGGMATVQKSTAGLIIYYGIFLACAEAGPGVATILIGGEVFPTPLRGHMLGFSAAWGKAGAAIGTQVFTPIQNAFHDEFKGQQVVFLIGSAVSIVGALATWFLIPDMDLELGSEDEKWKAYLKEHGIDTSGIGEPLEASASKAVRNEIVESGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD04</accession>
    <name>K1VD04_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD04"/>
    <dbReference type="STRING" id="1220162.K1VD04"/>
    <dbReference type="eggNOG" id="ENOG502S9H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1046576_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD04"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="29698" checksum="313AF638874A782C" modified="2012-11-28" version="1">MLFRLTVGIPLRAAWRVHQRHRHDMRQNDECTESEIGPRGFSTPRNENRQITKLWARRARNRQRARPHRSCRHHASGIVRDAVMMLELQEMVLQAGTAESGIGLCGVPRIYGDHALAPTAHRSARRQAACSSPARSRSTPQGSGQITNFTQAQRTPALARQFSASAQRGDLVKDMYLNQLKNYKAPATSKADAEQHVRKFTAPEPPKAPELPSDLAADMSAFDAQNPTIGGPKKAVKAEKTESDGMTADQYLKFLEQPLPKEEKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE02</accession>
    <name>K1VE02_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE02"/>
    <dbReference type="STRING" id="1220162.K1VE02"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431605_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE02"/>
    <dbReference type="OMA" id="MIERWMA"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="634" mass="68726" checksum="BB70419A0E9B9A62" modified="2012-11-28" version="1">MSSTSPASENETTQPSQTPPIETQYNSEDDLYPDVPSSAANARPARSKKTPKKGLKHPSSKGKAKDTSDEEDTGGGHCYLLDLPSDVLHLLLVRLPPRSLLQLGATCKLLNEMLESEAVWRRCYINRFLYDGAANSSREREEIRVLVQGCKGVGGRGWKKEALSREAMIERWMASKSPNLVHMPMVVMVHSMSLSYPPNLNTKRGIPGKVSGGSGSGAASPSPSTPTPGQKLSHRQKYEAMIAVSTRPPPVLYSAGMEVGALVKSDPITGKVSKGFWGPGPDAIFMPKRSQTHILWGLITGLTVHTTIQSRSHATHGGRATSDNVTSAIDDMHEGAIVSIHQPESTGTDPLKWVTGGDDGRLKYWRLNPGTGRSGKKSATDVPATITCVFSSEPVEEPIVERVEESRLRQMAHPDAIIKVACDVEKDVVCGVTEDGDLRLWFNASTAPREVRVDVGSERELGGVRQLELFCRETKDGLVASVLIHHRKNAMFARYDISLNANGKETIRTIFYSTPAEAPITAINANLLPVPSISKPPKAEQSMFARIITPASASASASGVTSPLLSPDPEPKKIQDEPHFGGFIMGGDNDGYAYIWEWDGVPYNDVIQPMRSWQAAEGRITAVEYSCGIAATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEB5</accession>
    <name>K1VEB5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEB5"/>
    <dbReference type="HOGENOM" id="CLU_1732783_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEB5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="151" mass="16804" checksum="2FCF4B3D52618191" modified="2012-11-28" version="1">MTNAGEQTTPPAQAEGEPISYHDVFGKKPPPRELFESVVGSLEDFKAQPISVPAPPPFGEVPYTDANVRNGLNGWQDQVNKHARDSHGQPFIDSTINHSLEAQAKVDEERKKRYRGRHTERVQVPAADAFKIGDPNSGWVEPLTCIRDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEC3</accession>
    <name>K1VEC3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEC3"/>
    <dbReference type="FunCoup" id="K1VEC3">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEC3"/>
    <dbReference type="eggNOG" id="ENOG502RPD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395967_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEC3"/>
    <dbReference type="OMA" id="TNYLNMS"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="696" mass="75106" checksum="14991C8BE37E62C9" modified="2012-11-28" version="1">MQQQQPPYFDPNMLSPNTTALLDSIAMGEYPPKQTVTPATFAPQALFPVPGRDTPEDSSPDSVKMNNATLKDHSHVASDDSDAELQGLNEVNNHKRKASRTTIADHDADEEDDSSDNAHEDKRQQVNDPKATRAARRKSGDGKAKPADKAGKAEQSNKAQRRKEQNRAAQKAFRERREAKVRDLEAKVAELEAKSFGTSVENENLRSIVKRLQEENIALKEAQFTFTMPMNGNAHSINGQQTPTPSLSQQQASAIDWSQFASFNKASQMGKPPSPPQSVSNDSLRSVHDNNSPPLQQVHRASTGSASESMEGPSPSDPNAVPTLFGNRNNGSFDMLKRPVVGSSPNDQLSTPSSIGTNKDDVEALFRSLYPNGIANGSSIDSVLAGTAGAPQQNPQIAQQQAQSPYTFLSAQPGLTSFADSSSNMMAKLFEPTSYRDSSSAEQDMLGGGSGQSTMNTVPNSSTSQTWADLVSGNQSDFLSSLSSTANDASEAGPEDDAFMKQLEQLIQSGNVPFNNASQAFSPTNYLNMSPSPLQSLSNSQTPRSTAESSDNLQSPHSDNMQGEAAPSCGASRIVHVVGEDGRVMRPSEVWTKMGLNTVSEPQDLLIDDLCDQFKGKATCKDGKRYMTYSDLVDMQYARDQHGEPPVMSGRPAEQPKLPAKPKVAERDCEKHDPAECQAKANELFLQQNAQPGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEU4</accession>
    <name>K1VEU4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEU4"/>
    <dbReference type="STRING" id="1220162.K1VEU4"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008076_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEU4"/>
    <dbReference type="OMA" id="ITSIWER"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1134" mass="126862" checksum="B96C17190AB0AFA3" modified="2012-11-28" version="1">MTSSPAAAAAKTAKDKKDKEPAKKIDMSQFPPERISRPSAPGELFQRRPADRKMTNTVPAEASPQFLDKLKVERERGITVKAQTVSIILTHTDGKKYLVNLIDTPGHVDFSYEVSRSLGACEGGLLLVDSTQGIQAQTLSVFHVAEEAKLKLLPVINKVDLPHAYPEETSEEIESSLGLPAEDHMHISAKSGLGVEQVLHNIIDKLPSPNYDRFRGVVSLVRIVSGSLKKGDKVSFLQAGKKYDVLEVGIQNPDEVPVESLREGQVGYVVCNMKNSAEAHIGDTVCLASQKVEPLPGFKPMKAMVFAGVFPVDSAEFPLLEESIERLTLNDRSVTIEKETSAALGQGFRLGFLGTLHMDVFRQRLEDEYASNVIVTAPTVPYKVVYTYGKEEYVSNPADFPETTDTKTRVAHVEEPYVNATIFVPSEYIGDMFELCAKYRGNQLEYRHLDGSDRVLLRYEFPLSEIVTDFFSDLKSASSGFASFDYEEAGYKQSKLVKLNMLLNSKPVDALAMIVHKDDAQRIGKAWVAKLREEMPRQLFELAIQAAVGSKIVARASLSAMRKDVTAGLYGGHYERKLKHLNKQKEGKKRLKKLAGNIEVPQTAFYNVLSQRPRTYATHARGSSSNESWLQEVVPAPPTSLAQLAEDSEVTDSVPIGRPTMAPKNRSEILGTIYKQVEQKSQGQTSNKLFGDFTRLYLSSPTPLFTAPELEAIAKAVHALDRNSSRKFQRQAHERFETVVNALRDVVGDQQHVPRGLELSMLVSSTKHKRSVNRSELKKAEHQFLQSFRSAPSDPARREQYRRGLNHIMYLAALSRQPERTEFWWNKMIGEGFEPDSWSYMSRVLTYGAMYNRTAAFLVELERALPKVPRKEDKIVLVNLAIWLAATAKGMDVAGALYTTINPPEETTTYSHAIAELPIGLIEELCELPPSKQTFYLMLSAYTYHGDLISALTTMQQLLARGHPAVVANYVSLFRGFSRFGKIHEGEAGAASELFPPLIEFASQSTLYEIKRRRATGFFDAIRGKSKVEEAPNHWTLEAFDQIFQSFLTLEPGKDVPGRGAPTAKGVYLALLAWSRVTNGDLHAVWHAWEALRAKFGPDNKEGWEGWEEDRRLRQLVQRLEKKIRAREQEQALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG38</accession>
    <name>K1VG38_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG38"/>
    <dbReference type="STRING" id="1220162.K1VG38"/>
    <dbReference type="eggNOG" id="KOG0428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041481_0_3_1"/>
    <dbReference type="InParanoid" id="K1VG38"/>
    <dbReference type="OMA" id="YHGRITF"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="364" mass="37288" checksum="DE0B77915A87E729" modified="2012-11-28" version="1">MPPKLNLRSTAVKRIMQEAAELSEPDEDFIAQPLESDIFEWHCTLRGVPGTEYEGGLYHLRVLLPATYPMSAPDIVLMTPSGRFEPGKKPAWGVRTAMAGLRSFWTQGGEALAAIGALDYPKEERRRLAKLSRDWVCPTCGVPNHELLPDAQVTASAEASGSGTSGAAQFAEAGAEVTERSELAAEGNARPDSSESDQGAVTTPPPGPSSAAAPTAVPLPPVHGPTAAAVSTEVPPPVITEPAPVPTPTTTAPVAAPAAAPVQPTPVRTGVSSSPPPPQPGSRPVPPARAAPPASSSPPPPAPAARPQPPAPPAVTGTPSPAESGQVATEPARRGQHAPSGSPLWLDGTIAACVAVLIYLLAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGP4</accession>
    <name>K1VGP4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000392">
        <property type="protein sequence ID" value="EKC98236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGP4"/>
    <dbReference type="FunCoup" id="K1VGP4">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGP4"/>
    <dbReference type="eggNOG" id="KOG2979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055164_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGP4"/>
    <dbReference type="OMA" id="NHEDAGC"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="12">
        <location>
            <begin position="196"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="301" mass="34063" checksum="C7BE72D170BE136A" modified="2012-11-28" version="1">MSRTTRTQNAEAGPSQSQRRRNGFSDTQFSTLDDESLRKPDLSDDEDGDEREKWTIDTFENQPVSKDKYGHLVSCFQGIKANRQLRALDNQIDDLITHVDIAVAEAKDTAVAIEDICPDDAMIDEIQAGLIRNLTTMDKLQLKKEAIGTILQRLNRQEDETNERFIDFRTGIWEVNHEDAGCPPMSTWLAKGPDDDEDEIEVGGVTQTFRCPITGGIFKDACKSTQCGHYYEYDAIIQSITVATRRGGNAKCPQFGCAQVLTKASIQRDPAMQRRANQFKAREEQRREEEEDLGDQSFMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGS8</accession>
    <name>K1VGS8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGS8"/>
    <dbReference type="eggNOG" id="ENOG502QTH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_2_1"/>
    <dbReference type="InParanoid" id="K1VGS8"/>
    <dbReference type="OMA" id="QKYAISG"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="25783" checksum="89620A685B0C5253" modified="2012-11-28" version="1">MSASAAATGAANGARKLRVDITSDTICPFCILGVRQLQVAAENYKKTHPSAPELDVHFHPFQLGGGGKFTEKPVNRREYMANNYGAERSQAFAQNFDRQYKALGLGGFASDAQLASSHLGHRLTAYAEDKKPEEAAGVALDLMKNYQVDGHSPSDRDRLAQIAVSHGLFPTEQAAKDWLNGNEKDAEVREQYKDAVDSGITGVPFFVFDKKYATSGAVGEDQFENILDQVIKKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHA0</accession>
    <name>K1VHA0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHA0"/>
    <dbReference type="eggNOG" id="ENOG502QSGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000488_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHA0"/>
    <dbReference type="OMA" id="NIGPGPI"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000157">
        <property type="entry name" value="Alpha-1,3-glucan synthase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853787" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2086"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2123"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2147"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2186"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2215"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2247"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2294"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2333"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2362"/>
            <end position="2385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2432"/>
            <end position="2451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2484"/>
            <end position="2504"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="182"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1752"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1783"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1814"/>
            <end position="1828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2512" mass="282570" checksum="DD2C482702248247" modified="2012-11-28" version="1">MRRGSSTREFAPGRWLPHLLTIGLLALVAGVRAHVYNETLDPWNLNKNQDATDCIDYTTHKRQNYTPSPENWRALPTYTMLADKWIDGDPTNNDFFGLIYEYDWRETQLRSGGDVAGLRDPRGLDYIQSMGYRSIYIAGTPFVNMPWQADGYSAIDFGLLDPHFGTMEEWAAWIDEALPTYTMLADKWIDGDPTNNDFFGLIYEYDWRETQLRSGGDVAGLRDPRGLDYIQSMGYRSIYIAGTPFVNMPWQADGYSAIDFGLLDPHFGTMEEWAAWIDEVHARGMYVIFDFTVGTMADSRHLNSSTPFNTNEYEVQWKLPDYGPWGINKYPDFNFTNDYNESCQYPTFWDESGVILDMGMEGCYASTFDHYGDVEAFGVFPDWMRQLAKFASVQDRLREWRPDVMDRLTVFSCMCIEALDIDGIRIDKAIQVTVDGLAKWSHATRECADKLGKKNFFIPGEITGGDTFGSIYIGRGRTPQMRTTTEESLNLTHDDMSKFIRDRYDAPVDAAAFHYSLYRAILRWLGMDGMLSAGFDLEVNFVNMWNTMLINNDFLNQMTGDFDPRHMWGVTNQDVFRWPMMAQGVERQLVGSFVTHLLMPGMPKAWYGEEQEFYILDSSASNYLYARQAMVATGAWKRHGCYRLGADQYFNLPYDRALMGCLDDKVALDHFDPTAPIRRTFRNMNYIRRMFPGVQDGFMLSRLSNHTEMVQYPGSGDVQTETGMWSSVRGPSPKQMGSGGIWNSDGDLTQNVWLIYTNLNVSKTWEVNCRDNPIVGPYNSGTTVKNLLYPYDEKTLEDVNTNEANRGCISKLELEPFDFKAYVPVSRWINMLPSISGFKPGHDARVLKNGDTVDIEIEWDQEMDCDSVNQALSDPEALKSTVQPGGAAPKLVPSGQYSGCQTIQNPEAHEFVGAAPSRWKWTGQIQNAAEGMYHLRIKPVSAQGGNRTTEVTDHLLFRVGSEQNSFVFPDEDYDNSIFEVSGGSYTLKHKAWGADKFRYSADFGKNWTPWTDMEETTELNATAFKDQWWKGDHLMVHYYSALGGTAAQVVHADANYDGPQRRWPQMLLRGKFNGWGYDLGMNAHLKQKDNGDWKIPVGSAWPSQFQLNIWAFDDYFYGDADGDGVIDRLPPNSLTPNFLNISAPPRPHLSWEIHVNDKTGKWSLTPLGHESSSIIVFALLLVIPVLTALAAAAIFRYSFYQIKINKWGQKPVKESSYFPIVGGAAHHDKKDGAMSEKHGAGAVVHHHEKLKPLDHPIGWPEVPSKRRKVLIATLEYEIFDWQLKVKIGGLGVMSGLMGKAMTDVDLIWIIPKVQDLDYPMGEYAEPIEVTIFGEPYLIEVETHQLDNITYIILDSPVFRAQTKSDPYPQRMDDLSSAIFYSTWNQAIAETIRRFPDIDIYHINDYHGALAPLYLLPQIMPVCLSLHNAEFQGLWPLRTKEEMKEVCAAFNISKDVCSKYVQFGNTFNLLHAAASFISHHQKSVGVAGVSDKYGKRSWARYPALWTLRNIDSLPNPDPTDIAALDDKQVDVDKIQIDADAEAKRPELKRQAQEWAGIRQDPNADLFVFVGRWSKQKGVDLIADVMPSLLEKKPKIQLICVGPVIDLYGRFAAEKLARLMEMYPDRVYSKPEFTALPPYLFSGADFALIPSRDEPFGLVAVEFGRKGALGVGSRLGGLGLMPGWWFPVESPAAQHMLSQLTKTIKLALKSTQEERAILRARSAVQRFPVVEWRQRLEDFQRRSIQTSRSLAGEHAWNFNGPSPDGPSFAPPPGDPAASLAALTARSGTPDSAMSQDYPGSNLPPGAASPGSGLLAHDYHRRFESPNRDSGDSYFDDGADDVSSRGRPKFFSGMDDDQSIMSSDPGDTTTVHTGAFADGGGGSSHAYDNFLAAANRQFAKNQGNKSVPDPFMERRQSSMSMNSEFAPSRPFSINSRVSSFDSISSIVDEKGASSSINKAMESFTDADGEVSQAFVQKLQNLSSANSKGDLCIEKFLIKSEKQFFSEMKREKLTAASVRSRDSFRESMFHSSHSGAPPAVDGFRPESPVYNSMSGHSGEAYSWENPGTFGAEEDNEKPMTRLQVLMDHSIWGWPLYAIVLSLGQLLSATSFQLSLLGGSNTQTAVDMYIICAIFVVATVFWYTLFRMRPSVYVLSLPWVLFAIAFFLVGFPSLHGPFIPPQQWLTKVATWFYAMASAAGFLFFGLNFGEEAGAATEVWIMRACVVQGLQQIWVSALWYWGYTLSGTDPDKYIPSVAIICVVWPLAAVSLLFAVLMYWGLPEYYHQIPPYVPNFFKTLVRRKLVIWFLISEILRNYWLSTVYGRNWQFLWQAADAPKWSIVIMIIIFFIGIWGLLLGILIKYSKVHAWLLPVFAVGLGCPRWCQMFWGVSGLGLYVSWGGGAGPYIGTCTWLWLGVLDAIQGVGLGMILLQTLSRLHVCATLAAAQFIGSIVVMIARATAPDKTGPGNVFPNPALYNPETGENNPVAHYEFWICLICQMVIPFGYFFFFRKEQLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHA7</accession>
    <name>K1VHA7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHA7"/>
    <dbReference type="HOGENOM" id="CLU_491067_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHA7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="526" mass="58567" checksum="73ECC8E36DC4E56F" modified="2012-11-28" version="1">MKAHDGVDGGTCTKAVAPPPDTDFVIVPRLAQAADPSLVTRLIEGNLEDWRGITLVTAEWIKLSTEMVHKFNELYDEYKIGEAKDVRMEADLDFGRPPIPIGNNLIVNVEELPQDSQSLKNGSINGDDASPSMPSTPLTQNGKEDTPIDDTPKPGYPFPASTKNADPTSPGTPSPPTELHTTLSAPPTPTKSKNKNAQRKAARKRAKNKKKNLGELEETEGEDESTTTDQSKPQEQELTVWDRVRNLKNKDTVSSITDPWCQQPRREKDQPALSWESIRDTSTPASDRFFTDELFDAYIRCLNDNLQACGVKALVLGTAFWTELLDECMHRHPARGPVSQYGLIRVGLTDYDRIIFPIRLGHIWSVAILDVEYRVVTWYDAFGSDQLDQKVTRILDILVITDPDVGSFDWKVQDVHETEPVNYSGVHAALSCEILARQGTHNDHLIQWLMVDPSVPKTVPDSWLLRAIRWVVFICAKGGYWDDAWDADMRRCKSQSQASKASSVQGRPVEVKGLEIIGLDSEAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHP4</accession>
    <name>K1VHP4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHP4"/>
    <dbReference type="eggNOG" id="ENOG502RBF3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2607721_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHP4"/>
    <dbReference type="OrthoDB" id="2595278at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="79" mass="8369" checksum="48AE2953493F18FC" modified="2012-11-28" version="1">MGSTDTATYPLKSKGRTDWTPEKRAALLETVIVAGSKAIDVEKVAADLGVSKSSVVDQLKPNRSNIRQTAIKAVKGANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHQ0</accession>
    <name>K1VHQ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHQ0"/>
    <dbReference type="HOGENOM" id="CLU_1180933_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHQ0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854158" evidence="2">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="25348" checksum="81C41C5F6CA49F1F" modified="2012-11-28" version="1">MLFATLLTAACAAALPLNFQGSDAAVAFPRAILGEVTIDRAVDSNVMQSSHHGKRQDTPPSPDEVLQTYPSFKFGLPPFQQQALLDLLRAMSQVRYDSAAATAEARMRFCSRAFPAGDTLDKRQDPIKPPEAALIDLHLPELVPASPGVQPVIPDRPGSGPPTPQVDVSVPVDKIIEDTRNRMKEALERLHSGNSINDAYKYMQEIADAMAKLSALAVLQASAHMKVSSPAPEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKL6</accession>
    <name>K1VKL6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKL6"/>
    <dbReference type="FunCoup" id="K1VKL6">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKL6"/>
    <dbReference type="eggNOG" id="KOG0869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_12_2_1"/>
    <dbReference type="InParanoid" id="K1VKL6"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="114" mass="12934" checksum="FA011D4622AE7689" modified="2012-11-28" version="1">MKNSLPTTAKVSKEAKECVQECVSEFISFITSEAAEKCLNEKRKTINGEDILTSMRALGFDNYEGVLKVYLAKYREHQINQAKQRSAAAENDEDLKRSGGAEDDDERKKKKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKV0</accession>
    <name>K1VKV0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Malate synthase</fullName>
            <ecNumber evidence="2 8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 8"/>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKV0"/>
    <dbReference type="STRING" id="1220162.K1VKV0"/>
    <dbReference type="eggNOG" id="KOG1261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
    <dbReference type="InParanoid" id="K1VKV0"/>
    <dbReference type="OMA" id="AGCDSCW"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="10">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="212"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="11">
        <location>
            <begin position="463"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601465-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="590" mass="65457" checksum="9A0E6C246E026E92" modified="2012-11-28" version="1">MHCTAALLRLKTAAPRAPLLFPVSLYCSPSCPSTRSNSTFTTPSLPANPTINFSTMAPAGVQLTLPIPQGAEHILSDDALAFLAVLHRCFNKKRLELLDNRKKVQAELDKGKPLGFLPETKAIREAPSWQCAPAAPGLQDRRVEITGPTDRKMVINALNSGAKTFMADFEDSNSPTWSNMVLGQLNLYDAVRNQIDFETNGKQYKLKENHAVLLVRPRGWHLEETRMIVDGQAMSGSLFDFGLYFYHNALETVKRGFGPYFYLPKMEHHLEARLWNDVFNLATAYCKTPTGIIRGTVLIETLPAAYQMEEILFELKEHSSGLNCGRWDYIFSFIKRQRALKSAVFPDRTDVTMTVPFMNAYVQLLIQTCHKRKVAAMGGMSAQIPIKNDPAANEAVNNKVRADKLREVTAGHDGTWVAHPALVPIAMEVFDKHMKGPNQYYNRREDVNVAAKMISDPKVPGAITDQGVRENIAAALSYCAAWISGNGCVPINNLMEDAATAEIARVQLWQWNHYGKSTDSGKKINVQNLKPIFEEEAAKVAKLPGISAKHVQIAKDYMLSQVAANYPSEFLTSDLQCHLDGGAVPRKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKY4</accession>
    <name>K1VKY4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKY4"/>
    <dbReference type="FunCoup" id="K1VKY4">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKY4"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="K1VKY4"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="493" mass="54850" checksum="E71F28C5DA0CD146" modified="2012-11-28" version="1">MSSTPEKYEEKYIEETAIEHSKGVTDVTELEAQQVDVKKLIRKIDFHLVPWLALLYLLSFLDRSNIGNAKIFGLEKHLHINSTQYGACLAIFFAFYVLFEVPSNMVMKAWRPSMWLPIIMVAWGIVMIGMGFVKNFAGLMATRVFLGATEAGLFPGVSFFLTQWYRKYEISWRISLFFSAATIAGAFGGLLARLINLMDGIQGYEGWRWIFILEGILTVVVALASFFTMYDYPGTAKFLTDAERVVIVERLHLDNDGCSHEFKSKFIWDAFTDWKVWCQAIMFHGSLCPVYTFSLFAPTLTQNLGYTAAMAQLMSVPPYVAAAFVTLGTGYLSDKIQKRGVVIIGCSCIGAVGYILLLADASHGSSYFGLFLAAMGAYPLVPLIMAWGANNCGGSLKKSVATAIIVSVGNLGGIVSSFIYPKEDGPRFIKGHAVCLAYQGAVIISATVMWVYCSYANRQRAARNAARGRDYTPEEKLELQDRGDHVDWFVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL75</accession>
    <name>K1VL75_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetoacetyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL75"/>
    <dbReference type="STRING" id="1220162.K1VL75"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="InParanoid" id="K1VL75"/>
    <dbReference type="OMA" id="DFWIDLY"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="129"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="694" mass="77398" checksum="DAABB9507993E3EC" modified="2012-11-28" version="1">MSTPELYWKPGDRRPHEDEEPFVEKFRKAVNERYGYNLQDWWALHAWSTKNTNEFLDFCWDYFKLIGERGDGPAFVEGIPMDEPQKLFPGANVAENILLGTESALRKDKWAMIATVEGDPNAANPHEPVEMRRISYYDLYHEARIAAHALRKMGVQPGDSVASFAATSCEMLIIFMATVAIGAIFSSTPAEFGVKAVVDRYDIIKPKVLFTIDKYRYSGKEHSITERACAVVEEIAKAGKLKNVVTFGQLSRDRQPAPETLEGYPSNVKSWDWASFMESGRDAPAEIDFYRGDFSHPIWIVFSSGTTGKPKSIYGPGGGIYLMRRVVITLHLNLDHRDSYIQFATMGWIVWNMHIMFSCNGGTIVAFDGSPFHPQDVLFRAIDKYRVTQLGASPRYIQTLNKAGVSPSKKHDLSTLKQFYTTGAPVTGDVYDFCARELNRLLVNNAAGGTELGGSYLQSTPVLPAYKGELQTPVLGVSVIAADANQKPLVGEEGILLFNQPFPNMPYNFVDDPDRKRYKEAYFEDSSNPPMLNMNDAVRINPVTRGWTVIGRADGVLNPSGVRFGSSELYFILEKDFASEVEDSLAVGQRMPNNDERVVLFLKTRNDAPLSPDLVGRIKQAIRQALSNRHVPAVVTQCPAVPLTGSGKKVEPSVKKLLNGVPLEKINFAGVENPESYAFYADWARANSGREARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLX6</accession>
    <name>K1VLX6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box binding protein (Transcription initiation factor TFIID TBP subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLX6"/>
    <dbReference type="FunCoup" id="K1VLX6">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLX6"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_2_1"/>
    <dbReference type="InParanoid" id="K1VLX6"/>
    <dbReference type="OMA" id="FHFKIAE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="25428" checksum="B6066324D92FD7EC" modified="2012-11-28" version="1">MSLAVPNAAASSSSNTASNNTPEKTGENDEYGKNNAVVRPQASVPEISPVQGLVPVLQNIVATVNLECRLDLKTIALHARNAEYNPKRFAAVVMRIREPKTTALIFASGKMVVTGAKSEDDSRLASRKYARIIQKLGFDAKFAEFKIQNIVGSCDVKFPIRLEGLAFSHGAFSSYEPELFPGLIYRMLKPKVVLLIFVSGKIVLTGAKVREEIYMAFKQIYSVLVEFRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM30</accession>
    <name>K1VM30_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_05249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM30"/>
    <dbReference type="FunCoup" id="K1VM30">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM30"/>
    <dbReference type="eggNOG" id="KOG2986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030279_1_1_1"/>
    <dbReference type="InParanoid" id="K1VM30"/>
    <dbReference type="OMA" id="HAENMHR"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD00412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="314" mass="35162" checksum="45CD709AEEE33E0A" modified="2012-11-28" version="1">MEQAERSGPAPLIDFIVSAPDLQAFHAENLKRNPDHYPLFARALGPKFIAWANDAWGAGLWYVTMVKVQGLEIKYGVVASDTLVRDLQQWRTLYTAGRLQKPVLVLTETPEISAALSANLRYALSYALLLLPERFSEFELWEKITSISYSGDPRMNIPGGENPRKIQNIVRGKNVLEGFRSLYSNHVGRVGLRFADNQSPAASQVAKFLWQGNGDATLQQPGNSEHLAQLLVDLPRPLKVKVAGHFKTDVDDPTAWLEISRKSGFRKVVEDEVKEIIRRPATTQSVKGLVTAGFTKSFWYSLAKIKKYLAGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM63</accession>
    <name>K1VM63_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM63"/>
    <dbReference type="HOGENOM" id="CLU_1556369_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM63"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013017202" description="CFEM domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="172" mass="16424" checksum="E51F6E1785F4B5AA" modified="2012-11-28" version="1">MKLVALALLAASAAAQNVAGKYDKCLTGCLEQTAKSVSCTLDKPECYCGSNNLNIATSTYALCISKDCKDLDSQVMASGVYGQICSNVALGGSTNNQGIPSAGATSPSADASNAAPSAGAASASDKAAPASGSHSSAAAAASASASAKPNSGATQLGASVLAVGGALAAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMN1</accession>
    <name>K1VMN1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMN1"/>
    <dbReference type="STRING" id="1220162.K1VMN1"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_5_1_1"/>
    <dbReference type="InParanoid" id="K1VMN1"/>
    <dbReference type="OMA" id="FFGIRGI"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="29"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="544" mass="59709" checksum="B0246731D3FE49CE" modified="2012-11-28" version="1">MVHLDISETSQVLSVIGGYICIVGLVSFFLKEKMFMSEPLVALLIGVAFGPIGADIFNPFRWVGYDQHQLESLSFQVSRIVIAIQVLFTGISLPKAYCWRHRLSLFVLLIPVMTCAWFVSALLVWAFIPNLTFLEALVVGSCVTPTDPVLANSICKEKYVPLEVRNIILAEAGANDGLGFPFLNPVSSLGEAIGQWFYNVLLYQILLSVLIGAVIGYIARRCLKYCEGRNLIDRESFLAFGVALTFFTVGWVGIIGSDDILCCFVVGNSLTWDDWFRIRSEEDSFQEVIDMLLNSAVFLYIGAVIPWNEFGNYWDITPWRLVLLGITVMLARRLPWVLLAKKFIPPISSSWKDALFTGYFGPIGVGAVFYIEVAHHAIPDDGTRERLRAVVAPVVYFMVLTSVIVHGITIPIGKSMQHTLTLTRSKSGAQFISRLPPPVPFGGALPTHDTNATSEPKEASARDVGVHDDATAPNSGTGTPAAFSRTNTLSMSRTNTMTQGVHWGENTVGHSVQSSGRTSPSNNDSTSHSSNPNLVQPSTHAMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMQ9</accession>
    <name>K1VMQ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000337">
        <property type="protein sequence ID" value="EKD00637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMQ9"/>
    <dbReference type="STRING" id="1220162.K1VMQ9"/>
    <dbReference type="eggNOG" id="ENOG502QU8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_1_1"/>
    <dbReference type="InParanoid" id="K1VMQ9"/>
    <dbReference type="OMA" id="DKWAYSF"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000001">
        <property type="entry name" value="Putative alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="108"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="353"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="814" mass="90974" checksum="AF4B4D92C2A71005" modified="2012-11-28" version="1">MSKVPTPKRRASPPPRVSETTHLNSPGKGAAPAPAPAPERRKTTATALVYGILLGFLYFAINKYQDGWTLNTVLDGEVKGHAPFDDGRKETAPREFVKPVSDALFHTNVMLGNDGPEPDLSGGMIPAVAPPFAMTRWTPQSRLNYTTLSGFIGTHQPAVWMGESGPVQVHAGIGPVITDFLQRAMPFKRKNEYASANYYSNLLHGYHGDVRAELSASSRVGHLRFTFHPNSHRVDPYVVLDASRRSVFTNDPNNVTYPLGWVRVDTERNEIYGWNDERQDKILLSEEIPAKGFKGYFVARFSEPIAKGGITCNGLPYAGLEAESNLLSGWAIFPRDTKSVDVRIGVSFISIEQARRNIDLEIPDGQSLAKTSRQTREAWAEKLDRLTVSGATPQNKTVLYTGFAHTLVYPYEVSENAGTKEEPKWKYYSGYLDKVVSGVSYSGYSIWDTFRATTAWQLLVAPERSGPMIQSMLQDYVQGGWMPMWKNIVETNIMVATHADSIVAQALNAGVTGFDKALAYAAVMKNAFVPPDHDVEIRYWDRQQHTPQEVRAGLTEYMKNGWVANDRHSEAGSRTLDYAYDDHAAAIVARHNGDEHNATLLEKRSKNYKNIWNKRTGFMEARNEDGSWAGEWEGWCEGDHWAYSLTVMHDIPGLVQLMGGKDKFEKFADAHFNGGHNLHTNEPSHHIHWARSLAESEYNHTALGLSGNEDCGQMSAFYLFTALGFYPVDPAGGEYVIGAPLFDKLDLRLPAADWTPGGTLKVRARGVSDEKQYVRSLEVDERAWRRITIGHKDIMKGAKLRFSMAKEPQKWPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN09</accession>
    <name>K1VN09_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">60S ribosomal protein L44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN09"/>
    <dbReference type="FunCoup" id="K1VN09">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN09"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="InParanoid" id="K1VN09"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046898">
        <property type="term" value="P:response to cycloheximide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-0196">Cycloheximide resistance</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00084115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="106" mass="12218" checksum="6CCFF4C729B50E1B" modified="2012-11-28" version="1">MVNIPKTRRTYCKHKTCKKHTPHKVTQYKKGKDSLSAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTSCKSKHQISLKRCKHFELGGDKKQRGAAISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN69</accession>
    <name>K1VN69_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN69"/>
    <dbReference type="FunCoup" id="K1VN69">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736057_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN69"/>
    <dbReference type="OMA" id="EARAHHY"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="376" mass="42657" checksum="2C88263F31164838" modified="2012-11-28" version="1">MWRFATYYRPSPHYLRHINNNNSLPRLNIDMSGSGVSQASLLGLKALTAEHADRFKKEGRTAVKGARKDRPEKVARDPFDRPSPGLVKRLAREARNDAKRRHFADDPDGPTRKRWRRAQRARTRRSNNRRELSLTRCLADPQFDRKRDEWSDHSSDVDESALEARAPEEFDTLDGNDQVEYVDELGRTRMGTRKEAIAAERAKGEAGPSRNDEPLVGESAYAEVISSTATSTTSPCTSQTTKRCGKSTWRQSAKRGNTTTTRQRKVSLGVREMKLTTVRTRGAGAYQFSLDEEERAKQMASLDAERRTTEQARGKTAARGMTPAQEARKRRLEERRALVEAKRAKLLGGADKVAALRAQRQAERAEEFLKDFEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNA6</accession>
    <name>K1VNA6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNA6"/>
    <dbReference type="STRING" id="1220162.K1VNA6"/>
    <dbReference type="eggNOG" id="ENOG502RB8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571330_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNA6"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852319" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="478" mass="52381" checksum="E9D083B4D243BB62" modified="2012-11-28" version="1">MLFSSLAALTALFAATPALAEDVTIDRSIQLKGTNFCLDNTEGRLEDGNKLQIYECWNEDKDQKWIWEQAEVYKDIPLYHIRLDGTDKCVAFKRPKRGSAAGASVVLAACDSDLMTYYTKWRWDKDWICSGLGRCMGVQAQEPVNGATLGMSTTGNAEWVTPNQGDASSKPMPLQSSRSSLVYLQSPSEISPLMASMSSVKTCPSLSTPQTRSAVTPRGIEPTSFAALSRAGAKLLLNGADPPSTLRNRPSTIANQLARTRSCDHEDPRAARGLPRIHRVRRCARVRTSSSTLILIAGGGSDVIIVVVVVRFGAERCGCEGLSGVDGAGSDPALLRAHIQKLDPAIDDDYFAHLWQLLVRKPNVEVVVAEDDEEGDLRPVGEDEEFPARNLAGLLLKYPRVRVRGSDDEIYYRLTGSRKRITPMIFNFLQVAARSRAAGMSAVELGPLFGCNQKSVFHYRMIFSQKAFSVSGEANMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNG7</accession>
    <name>K1VNG7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNG7"/>
    <dbReference type="eggNOG" id="ENOG502QTP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003283_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNG7"/>
    <dbReference type="OMA" id="LYIMFIM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="638"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1371" mass="149878" checksum="960A9AEA9E93D78D" modified="2012-11-28" version="1">MQPVASSSKMRLPRRPARIAASTATFVLALTAPYLAAARPLPDSSTATDPAATATLPTLLHPTPFASPSQHSPPSTLTESALLATLRGLQRLVQISDGFLQQSANPDWPDMDMSRMPEAQAVVNALPKNLNFPKGFVVLEQEMTPGFIVLSYFISLVGSLCTLELLIRRTSNRGLSNIAFLTAAGICFGAVSTFAMHFVGNQALALYHPLDPKRHALYLTYSAGYTVLSMVASCLAMIFAFFVMGTDVSLGSRPRIFRRRNSLELRRHETIERWKAQRPHLKATNVDTIFAQAGMSGGWSLSSQTPSTTRRTWYQKLLGRDAPPESRFGDFEDDDVLDESSLVKRDKDLDELNFRLGREAVRAELDRRQILGAAQLPATESPGTTPNTSLRGMPMHMTMGLGGTSAFPKSPLAPYYSAEDTALGTINSTRSRTPPSPMNELFATSYQFPPRSTPHPVDSQTHLIPKSDGSTSSLMSSVPTFPRPYAPILESTTPAQIYAPPQHIATGRRSSYPALAATPLPRAPPTTALARIQSLPENDADSNGGPYRDSSESSKDNQANGSGSDENTIDLHIDHLDHVLYDDEPFRLRKVGWREELRDKIQAGAPLTKRERALRFFGLDIVTLSDIVKVVLTGTFAGWGVAAMHYVGQISINDIPYIGYRVAYVVGSVVIASGAVCVALYIMFIMLRPKLKHSWVSKIVVGLILAGAVCGMHYTAMMGTIYGWEADKRPDKGAESSANKRAITGLVAALAFVACLGVATFILVNSIRDRKERARRRRIVVASVLLDEQGRMLVSAIDGLLPMCDIASLTPRDVKKKNQKNVHDQLDLTTANDAFVQSLKMSWSWRNPFWSAMNPFASVTDLLTGNSTDDMSTEMSGLGFSHPTLGRRPSTFTNAESVVSGHSQPTQRLSVARFLERFALAATQLSVRLTGQQNGIGRLGVLYDHILTTGWVNLSKNERVSKGQLIFLVRRISSVREKSDLLSRHFIFAPPSAVATALHKTLSTPYNNVMPLLEDMRGFVDTSMRMTLRPNTLYAGVVVVQATPFDGLRILLDKQNRSQLPMREVCTFSTLSGLPVNATRDEVLSGTLEEIGEAASWLEGMTLLSVISRNMNPEGTRVGGPRVGRLLSALERAIIPLMDDLLSQDDMAYILPRLQLHPLLVPLTPATPGVNGHPGWAAPHMLVFYANYDFAVRSFAEEWAPFSLFRAQNECVMASKINRLERAAEAAAALQRTTPRAPSPTLLPGTPLPPFSPLPAASPLPPGTPTDVAAKYNSGRRPSKVQFQEPDPRDAPSPVPTNSDTVSSRERPAPRRSSLARTAVMSSTAESPMIGVGVWDPNWLVHLLRTHLRAEPEMIGKETEQEPAMTMAISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNL1</accession>
    <name>K1VNL1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNL1"/>
    <dbReference type="HOGENOM" id="CLU_973825_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNL1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="32086" checksum="DED3BC5B1A659770" modified="2012-11-28" version="1">MREHYSSFPPPEGVNRKRVLALLEEMKTCTAKLDAGMLFVKTSWPLFKSEVEAFQGSPGEPTQTLDTIRTVMEFKRTQEEFDHIFTRLEKQADALRRLRVQVMHACSAPSSAVETDTVASSADSLSEDNLLDVDEQPGTPPTSLPDTSSEADPAALLDEPDEQDELNASDIDPDIPDLVGEAEASVNALLAGIAAFTNPGMFGDMMHLIDCAAQYDAGLEWFEEHFHAHRVHIKSFEDNSHKTAAELEDLVRATEELECISKKLKEMRRNLRLAENRFRRKYLCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNY9</accession>
    <name>K1VNY9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNY9"/>
    <dbReference type="STRING" id="1220162.K1VNY9"/>
    <dbReference type="HOGENOM" id="CLU_030902_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNY9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852297" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65949" checksum="62C9C148CFB19059" modified="2012-11-28" version="1">MPSYQWFCATWLLVARIVIAQFNSTVSFTLTSLDRPVDVDAARSWYGGLPFTVDTDNGYRTSTGRSSGVWGSSFVGTGFEVQGFGLWKYGSGPSDPDEDGNTGAVFAYLCPSDREWQEESLLELTGDVTDDPRLFAASNMPLSAYDLNWVLRADTQLEFHNLTIDIPIRTQAPSLVDLQSQATFVPTVQNGQLQSTMSLGFSSKLRQFRDMFRGRKEIYPPRFSANDTGVIQYEKRKRGVTYRLEEGHIMLRNMTELSYTAPPNTTLIQIFGPVGQLNRSSAGSMCYADLDPPPPWWKNTSFPNPLQRRRSMVSIARCSYSQSIRAYRLQSEWGLWDLIRHWVHGEFQRLQSSNYTLANLAAVDSGSDGGGIEASSGASSAESKHRTDIIVGVVVGVGEALVLTAILAWLLLRRRKQQKGKELGAEPYDVSEKDLYRTASWAPHNALDWPDTPLNRSGPAPVGSTRPRPRRIVQEQDAAEGLEHSPPIYEGEQLTSAVDGSTPGWSSPDDSTRPLANGARERPGQPSALKIDTKGVLEAGPDSASRYTTHVTTPQLKEEYARVFGVPRSPAERTARTPEHTPPLKEEYARAFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP91</accession>
    <name>K1VP91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="K1VP91">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_0_1"/>
    <dbReference type="InParanoid" id="K1VP91"/>
    <dbReference type="OMA" id="DTGMPIW"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="874" mass="99224" checksum="89BF40AF3EC6249E" modified="2012-11-28" version="1">MGEQEKYSDHDSPEPLHYDEKSVPYDEKKDYLGAEVTVTAPFGEAEDLDIAYRRRLHATEKDILAAEALLPTMPEDRARRILSQIRKMHKHDQNFDLATLEQITEFLDDPDVREHPDKHAELILAMRVEAILCTENSPYAMVRGSVDTTDDMSIPALTSRVWIIGILSCCLGSFVNQLFTIRFPSIGIPSSVIQLITYPFGVFLAKVLPDWGFTFRGKRYTLNPGPFNRKEHMCVVIMANVGMGSPYMSDIVFVAALPQWFNRDYARKYGYQITNTLATSFLGFGLAGLARRFLVWPSYCVWPDELGTLALNKGFHNDEGTPIPGPGKKIYTSTRMRLFYITFVCMFFYFWLPNTFAGFLTYFNWIAWIAPNNIDLANITSIRSGLGINPWPTFDWNYGFALTTPTFSVVSQFVGMFLSGMVIIAFYYTNAYNTSYLPMMSNKTFDNRGKSYDVKKIINENSLFDMAKYQKYSEPWMAASNLVNYLFFFAKYTAVLTYAPLYHWHELKIAYAGTFTQAKNFILRRKDVKEVDPDAIGEDVHYRLMRKYPEAPDWWYFFVFCASIVLGVVGVEAYPTGTSGAVVVYGTIFALIFVIPVGVVSAVAETEVTLNVLAEFIGGMMSGGNALSMNFFKMYGYVTTAKSLAFVRDLKLGHYAKVPPRASFIVQCVGSLICAFVTTAVLNWQMSFEGVCTDEPKFRFYCYGEWTFYTASVFWGTLGPARVFGKGSHYWTLLLGFPLGLVLVLGVWGLQRIWPKSRLLRSIHVVAITTGAYWFPDTLGMKWTFVVTTLLSWNWLKSRYLAFWSRYNYVFATAMTAGVSISAIVQFLAFTFTDVEFNWWGNDADKGCAAPNKCKRFQIPKDPGYFGGAPGTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPX4</accession>
    <name>K1VPX4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPX4"/>
    <dbReference type="eggNOG" id="ENOG502RB7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1547512_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPX4"/>
    <dbReference type="OrthoDB" id="2568061at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20051" checksum="11866C1309E6B7F7" modified="2012-11-28" version="1">MLTCRPGFIKSVTNGMLLILAYVNFILNVILIHRSKQLYGLSHYPAAGVAQMVLGICQMLWMLAYLCWGKRKFFSTTNMMAVNGIWTAYGLGSAIALTYLGHKHGNGYCPPTPGSGAGGDCAGILRGSEGMAWSLFGWDLVWFGVIAWVVGKYNNGNYKTPLGLVPIKRRAYDEEKEDAPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ64</accession>
    <name>K1VQ64_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol/phosphatidylinositol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ64"/>
    <dbReference type="FunCoup" id="K1VQ64">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQ64"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_7_1_1"/>
    <dbReference type="InParanoid" id="K1VQ64"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="366" mass="41097" checksum="688FC011A6563321" modified="2012-11-28" version="1">MEVPETAEAFRSHMTDLVQQYGDIELVNLVNQKGYEQPVKEGFERAMALTAMDPKLAQHCHYLYFDFHAECKGMRFDRIQLLIDQLSDQLNKDGWYSGSAPVSAGYGAAAGPTKELKKQTGVIRSNCMDCLDRTNVAQSALGKWALNNQLRDAGILSIKETVDVHPEFMSVFRNVWADHADTISKAYSGTGALKTDFTRTGKRTKAGLLQDGYNSVMRYVKNNFFDGDRQDAYDLITGSWVARRGAIPPLSDTRPLLHRSMPYIFLFALAMILAALTLPRSSDWSIASFLLLWFLLLAISGTFMWGNGTHYVAWPRLNPPHAILNYSGNGFRSKQRGRGMSISKIVPVKKRRGDEIEMKRKGALID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQP0</accession>
    <name>K1VQP0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQP0"/>
    <dbReference type="HOGENOM" id="CLU_585512_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQP0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="467" mass="50887" checksum="E2F428DAD5F0AE59" modified="2012-11-28" version="1">MEESDMSPHVGSSHSATEDANLSEGVDTEPGVDNAVQRLSSDAEADAEPVLPTSGGPIIFEADEGTDPSAAAPDSLPTQPNVEVEASSSVPLPGAASSQLAQFSDAENQPLNPSPEPSTTQNVPEFDDDCYCSDCLSDAEDDRMAIDGDMDNASEGATIDAASFPHIVDAIRDYAIQVSPLTVRRVHRAWRTSADHHLGRHIRLDLRAPGLHRNGRQEPYLWLFSSASTRIPFLKRSLGRPDQSELRRSRTDARRVARILDVHACTEFVKRPVDISDWRKLHTVRLVQGRGSVAFHTAHTMPNVKRIVFSDGPYDRNHAAACPPVEQMFHGRYLRTRRVVCNFRTPGNSDGGDIIALPRLADLVLILHGWGVIPGFDPTEPLGVNHPLDEIRGLAYFAALEGTRVTIVNAALADLSNGRRACNMGDVVETLTQMWTADLRDEEMADGAPIDEQQVLGMIEFISLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS33</accession>
    <name>K1VS33_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS33"/>
    <dbReference type="STRING" id="1220162.K1VS33"/>
    <dbReference type="eggNOG" id="ENOG502QQ9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006273_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS33"/>
    <dbReference type="OMA" id="RSFPYTW"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="418"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="946" mass="103106" checksum="D9A4713EFF7281EC" modified="2012-11-28" version="1">MSAQARSRRAADIEKAPLYTDNPYDHEEVDDSGKKKGHAFAYTVNGRPVLSLVMHPVLLSLATLVLFGYLNFPWPDSPLPDHVQEGIKRCEAIKAGPPNHQPNADRKTSDRFVKGTRPVWLKNGTVWTGEKRGEQVLHETSVWLEGGVIRRVGKEDGDFADLVASSKDKAEEVNLHGAWVTPGIVDLHSHLAVDPSPNLRGSDSTNSWKQAAQPWLRSLDGFNTHDQAFNLSIAGGITTMLVLPGSAGNIGGQAFTFKPRWTEENTPQSMQVEPPFVIRNGTWERTGAWRHIKHACGENPLRVYGNTRMDSAWDFRKTYDAGRKLKEKQDAWCAAPKEQKEAFPDDLQFEAVADIIRGNVKVNIHCYETVDLNDMVRISNEFQFPISSFHHAHEAYLVPDLLKQTWGGTPGVAIFANNAYRGTPYAAKILADAGLSVVHKSDHPVLDSRYLIYEAAQSHAFGLNFSEALSSVTTHSAKIAGLDHRMGYIRPGYDADVVVWDSFPLAIGATPKQTYIDGIPQIIHPHVQEKPKDAQKISPAGDYDKEVAEAVAARGDPDLRPKHKSKRVLFENVEGFYLDGFDVQGVPGRVVVDGGEITCVGKDCAVTSGEHETVDLKGGSLLPGLISTGSALGLVEIAQEESTWDGVAYDPVHEKGLLEGILVRGADGARFGGKDLLMAYREGVTTGVTWPVSGGLVAGLAYSFSTSAEHPLAKGAIGHPGPALVLTLSGWTTDMTESVSTRIALLRKMLAGEGVKGELAEAFKRAASGELRLVVQVSSADQIAALIRLKQNDAKKLKLTIFAGEEAWMLADELAKEDIGVIVANPRPFPAFWDSRRILPGPPLSNHTLPSYLASRGVTVGLGIHEECDARLARFEAAWAYTAAPHVFSKKQAVDLVSGNLEKLLGLDLKSKADTGFVAYEGDFFSFQGRVRASRAPGQEDMHLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT18</accession>
    <name>K1VT18_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT18"/>
    <dbReference type="FunCoup" id="K1VT18">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT18"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT18"/>
    <dbReference type="OMA" id="PPRMATF"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33571" checksum="79B3DEC3BBDAB5D6" modified="2012-11-28" version="1">MRILSTADVETILPTLSPSDLLATQAHVFKLFSAPPSSDANSTSTLPVHAKGQIDPVQLPPRMATFSPEGRTLYMPSYVDGLGSGVKVLTRTAGGMKTNMMLIAPEGGVEAVVESKALTAVRNAAAIGAKPRKAVIFGAGDQARAHLKLLKQLWPELERTVVVRRDPAMPIPTDLAERVLLNSDAGVAQALKEADAVVTATPATEPLFPENALRPGTAVVLLGSSRPDMCEVPPLLLRTARVVVDSKEACLREAGEVIQAGLTGDDLTELGTLLASDGGRGSEEGEITVFKSVGLGMQDLAINRLVLQRAEEMDVGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU22</accession>
    <name>K1VU22_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU22"/>
    <dbReference type="FunCoup" id="K1VU22">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU22"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007739_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU22"/>
    <dbReference type="OMA" id="MGWLEGI"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="345"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1119" mass="124270" checksum="014FFF0E7C3BAD29" modified="2012-11-28" version="1">MSGVDPSNLPYKARQPRARPQRALPPPPDEDVATEVAMDLAGRFASPPSPPKAPPMQLAPPPPPPADAAGRDPNNMSRGNSASGASDNSEGRRERPPVPATVPLVDPSHLNPYHSTLPDMQPPTILTPLRAHYLKKTLVNLQIAHELSVITDPVLGANALGLLGPPFILPEEAKQLVAARIGREAIPSAYTTGDLPFMRYMFHQFMLPFPFLAAAPPTFWSHKVQPFLSSFLATTGAAQHATKTPQELEIAESLMTKEEKKEAEEKKKLWAKMEKHLGLMIGVGIKLVGGEEVVRIGQSELRRIEQAQEEKRRKYAEKHAAEGHPPPMIAFDVNVVGVRTIVPKSRVRHKTHEVSSCVADNANVQEFLIRTQRTGVADVFVSRRYGDFRRLAEELRIQFPDIELPNPPPKDKSAANVPPKTEHSGYSAYNPLRMIYGSGTSSPQQSGTNTPSPRASGETERPDNLDGATLPPAMPLSREKNRLTLRAYLQSIMSIPEIANSPVMRSFLLSAPTTLTPPEAADVQRRLEADAVREEGRKRFREEAERRVEALRGGLAAFKGDILSQEGGLKSVFDVVRRVERVEDLPPAEKSVLDFAATIFQLYVASDTASDSLASLKRLHGIMPYFMLKGILKISNPMAMIRGILDLFLARPFGGQSLLQKMFSTSLTEDLRYLAEDIAAVQDKIDDPVLCQKVEQYVRSSWEAQEVYRKEAVSENCELLVAILRSPEAPSLSRGQIQRVFRASRAYREWKAEQAEYDDSDDEEGPDNDDAWLFEDLNILLKLMTRKKEKEAMLALIFEGVTAELLKDIITIFYAPLATVYKAASIADSLGDLQAFINDMIRTVEQVEELSQEDPQRTVQTFIDLVQRHEQAFYTFVHNVHTKGQGLFDSLMGWIELFLGYARTGLDTPLDLENLLPMGGPERAAIMAEVDAVAQYHYKLKVAHEEKVRRRFQSAGMDQQATEEAQLVDSVMQSLSLGENTVGAAEEVADEESDEEEYDERYEDSETSSIISGASTLSLNAAGGKRTVPPSPLATGEHHRHRRHGSNGSNEPPPVPPKDGNPLPVPPKANHQQQGQHKKRRRKRNLQTLQPPKTPHLDELRPLFVEAVKPLLKVKPIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU48</accession>
    <name>K1VU48_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU48"/>
    <dbReference type="FunCoup" id="K1VU48">
        <property type="interactions" value="649"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU48"/>
    <dbReference type="eggNOG" id="KOG1126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008850_4_0_1"/>
    <dbReference type="InParanoid" id="K1VU48"/>
    <dbReference type="OMA" id="WVMAMVG"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="759" mass="82547" checksum="B536C5349A4E19E1" modified="2012-11-28" version="1">MAPKPSGPHLAQRLRTLSLTSPPATGLFYARLYYALFPPTEAEHDSLHVLALCLLQSDQPYPALQAVRDSANGDGDPDDMDYESTDKPGCYGCAVIVAKCCNRLSRFTEGQAVLERAVRRSTPMSESRVSLTQLTAALPVVTPAETAATANLMLASLSHKGKSPMQAVEFYAKALSEDPWLWEAFTGLCDIGAPPSPETVFPDPPSARSSARPSRNATLSPGPMPRSSASEVPNFISRRQMSPLATAAPTTSSLFTPGVSNHPPKFGMLGNPSNWETPSTVADTSFPGFNDQGPSGRRALPNLMSSILPSSLRATTPINAAPDLMSRPPAQKRPRAAHGPRRFAAADTPTGGPLAGESRSNGRDLKSLDTNGDKMLEAPVRRSSRLNANGPTKPQPRVTRKDRSTRSQSVASSASGTAEPATSAADAQVQAAVDDWLRDIVRRCARAYRSLRLYNCKEALSELDELPLELQTSVWAYEMAANCFYEMSDNVKKLISADPYRLTGMELYSTVLWHLGDTAALSHLSQHLVSIDRDAPQPWIATGNCFSLQRDHDEAMRCFRRAAQLSPGCPYAWTLCGYEAVAMEEYDRAIAFYRNAIRADSRHYNAWYGLGVVYLNMGKLRHAEHHFRRAAEINPSNSALLCCIGDVLEKVGNLPGALAVYDQACAVGSTAMSVYRRARVLVALGRIMEAISALEPLIRDTPDEANVHFLLGKCYLRVGRNDNAMTCFTAAQELQPKLSSSIKATILARGEEEEASEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU76</accession>
    <name>K1VU76_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU76"/>
    <dbReference type="STRING" id="1220162.K1VU76"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073162_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU76"/>
    <dbReference type="OMA" id="WKATFRI"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="36759" checksum="4E7335ADBDA34E24" modified="2012-11-28" version="1">MSLIFRRALTTGAGPSNSIPLAVRRRRTELAEAVQKASPLTQPEKFTGPDAEPFPTRMEEEFQDHRAAGNFAGEESAARAKFLEVNQLWRSRVRGVSGAAALEGGAATPESKWSFFERAGEGQIPLKEGMRQAVVGQKIWLPNIQIRLVRNFTPPGEAYDPWKATFRIPTGMTKTDLRSYLQAVYGLDVTYIRTDVYVGNVTRGRSGEVMRALRSDNNYKRAIVGLREPFHYPDDVEEMRAGQWGTLAEGAAQAEEREDLLNKEFAVEHVKYYRKQMSMKMKGWRWRQNHANAAIARAAEGLAKKDVAPAAPAPAESAEPTEPAQPQASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUB0</accession>
    <name>K1VUB0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ER to transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUB0"/>
    <dbReference type="FunCoup" id="K1VUB0">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUB0"/>
    <dbReference type="eggNOG" id="KOG3998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056195_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUB0"/>
    <dbReference type="OMA" id="RHRHFPW"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="323" mass="36270" checksum="B0B220F8C18CA1D9" modified="2012-11-28" version="1">MSQRIHLNPNRGQVPMMNQGYQPDPIRTSSPGFQKSDNELVAKIQEVSSKIEDAVDSISQPIRPYIPKLGRFLIVVTFLEDALRILTQWSDQLWYLQKHRHIPWGLSHLFLLANVLLMLGGSAGVIMQRYPEISVGSLLGVVVLQALGYGLLFDMSFFLRNLSVIGGLLMVLSASLQNKKMLFAGIPSLSENDRRKYFQLAGRVLLIFLFIGFIFQGEWSVGRVIVSIFGLVACGMVAVGFKAKWSAAFLVILLSVFNVLVNKWWKVHSAHPQRDFLKYDFFQTLSIVGGLLLLVNMGPGGFSVDEKKKVSFTFLIKADNQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUK0</accession>
    <name>K1VUK0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUK0"/>
    <dbReference type="HOGENOM" id="CLU_529124_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUK0"/>
    <dbReference type="OrthoDB" id="10564755at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="492" mass="55076" checksum="DECA11E56BA545BF" modified="2012-11-28" version="1">MTDKSPTVAIPAGDSDVKPSASSSSAVDRLMSIPHIVTSIIQYASRDRPTLARLMRLDKTFYKEVAPLLYHTVAIWEETIDSFFRGSFKPCGCDECLERLKDDWGIDRRADGGLTEYGKLFSKPHGYGRYTNPAPRPKTPHEDEKASSPVRKSPKDEPLLKINITENAKNVQKGPRASESQDVEGNLEAVDDDDNPAVTLPISKKDLLRLVRVFTLGSHHESGCGIYSKHVQEFMQGVEILRILETPCAPHRTFHICENCPGGSCPIVDALNPRKIVVRNVSGLEVPFPAMWKANSKTKEMVFVLPTKMMSYTGKDSCPSEGLVKSLIGQFTEVDVIRVVFWPDWDDSLTHHPLARKLVGDAEARAVQAELGGKPLSADYIATVMHALTKTRRLDPWDFRRPRVDFYGFSTTSLSAYGRSMLVEEHQKQKGNAAYDLHTLAKQWTMRKEIGFAYNSAGGGFVTGSCDEVSWYTIGNYERKKFKSEINEWDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUT8</accession>
    <name>K1VUT8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUT8"/>
    <dbReference type="FunCoup" id="K1VUT8">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUT8"/>
    <dbReference type="eggNOG" id="KOG3065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020823_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUT8"/>
    <dbReference type="OMA" id="HNMERED"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="338"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="401" mass="44946" checksum="0C6038989F4D79F9" modified="2012-11-28" version="1">MGFFKRKEALTIPPVEPSGGIPDRRPSPQPMRGGGRPDPYTSNSYGGGRNNGPPPQQGGYQPREHKDPYAAVQADRQMGSNPNNPYARKGVPSQADRDNDAARNELFGGMKPQGQGPSREGTPGAGGGRPPSYATEEDAARAELFGGMGGSQGGGEIPAPRRREYGYQGRELEEDFDEDEEIEGIKQSMRETKQDSLQSTRNALRMAREAEETARGTMARLGDQSERLANSERHLDMAKANNQRAEDKAQELKVLNRSIFRPAIVFNKEGKRQAKEQKILERHNMEREDRARAMRDVQDSRRRLGEAANERSFQDPSLRADRRLQRQRYQFDATASDDELEDELDENLNEMLDISKRLKSISTAMGSEVDTQNKRIGKITDKTDDLNIKVSMNTDRLKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV05</accession>
    <name>K1VV05_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV05"/>
    <dbReference type="STRING" id="1220162.K1VV05"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505392_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV05"/>
    <dbReference type="OMA" id="WISTTHV"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="167"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="52753" checksum="E6193B2A95770D80" modified="2012-11-28" version="1">MLRTLPRLLPKPASYARPTTLRGSTGLTPRSLLPLLQHPNQSTAPQQPPRPVLPTPSGWSSTLHAAPAAYPRSLASAIGTNARDSHPFATASAAGNAQPVKESKEERNKRLALEKDRCIAARHDSPVWPFDTALKAEHHPLWIAAERWVNSTQAPDGLTIITTHACGFSKESWRPVFAKLFPLLEAGAESGAAFGTGERLPGDAPHINEIWFLEDTNHGVSVDLNKGRLGDALCWDDSARELINFVENVLPAVGDEADEAGFQLPFELGGKSAQQAGKTPADGLKRKVVGIGHSYGGNALAQAAASRPDLFDAILLVEPMTVPSLVNAGESGSPLTMGALKRRSEWPSLAEAGNVRSNALFSRWEEEQFRIWLSHYLVPSPSGGMELATPTWAEAQTFSEPDAPMRGWECLPDLGMPVGFLMAGDETWMTGEEVAQELVWRPQRARNERILDASHLVIQEKPAETAASIGRFLRTLPSWDERPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVA4</accession>
    <name>K1VVA4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuole transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000250">
        <property type="protein sequence ID" value="EKD03422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVA4"/>
    <dbReference type="FunCoup" id="K1VVA4">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVA4"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017092_1_0_1"/>
    <dbReference type="InParanoid" id="K1VVA4"/>
    <dbReference type="OMA" id="YVERCCH"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="8">
        <location>
            <begin position="187"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="491"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="536" mass="57966" checksum="AD95237BECC0E140" modified="2012-11-28" version="1">MLTSGPNRPWTNRSQVQALVDQACDPTLLSSNDVVNVELAEVINKKRANSAREATQALLVYINSRNPNQSLLALAVLDYLVKHCGYAIHLQISTKEFLNELVRRFPERPPMVVGRVMGRILEMIHEWKNTICVTSKYKDDLVHIRDMHRLLSYKGYRFKAFDAARAMANSNPNENLKSPEELEEEDRAAKSAKLQELIRRGTPRDLAAAQELMKYLAGAEPDKTVDYEKETLKELEKVQSKAVLLNDMLDNAKEDERIGVEGDVYDQVAAACKGARPKIQRWIETDTGEHEGLMDKLLVCNDLINAAIERFEAAKRGDWSAARNITVPQPGAAAGSQRSGGNDLISFDAFADDDEQPSGGLALPSGSQAAPSTTNPGFTAGGLPLDLFATPSPSGSPAPGPSTSSGPSQPRKDPMAFFNQPSQPSQPVQPQPQYGGLGGLGSLQTSTPPVQSQSPFFQQSQPTPPLFGGSQPSASASPAGGNFPGYSVPTSSNGFSSPSGFPAQQQPAQSTPQAQQQQQQQPKKNDAFADLVDLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVP3</accession>
    <name>K1VVP3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVP3"/>
    <dbReference type="eggNOG" id="ENOG502SYS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049655_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVP3"/>
    <dbReference type="OrthoDB" id="3366178at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="447" mass="47683" checksum="2BDF53DBF4ACE869" modified="2012-11-28" version="1">MAAAVQPHSILLPSSSPLGAGNNPVAVPNKAGVQVQAPAANGVHQQNGVAPPAAAQQPQQLNKMPGTTAHAVPVHQSAGSSQESLASNAVPPLSPGGSQSSTLADSVKTDHTWDDAETQTNTSSTAGELTPRSSMMGSPTPKIRFGNCPERPPELRRRNSITLGVLARKSMLHAQGTLPGGTRVVNMTDEEWEAYQNKFQKSTQAPVDLGNVVSSGAKKLWGKMRRGSNASVGSTASSAAGRGRSDSASSMPGMPISPRVRPVDTAPPIEEHVEEEEEDRVHLPARMRTPPPGEETPRVGRSPSPPPHPTFDDEDEDEEEDDSSSDGGDHREADDGHGLDDADHVHRSRHSNSVAALGFEIGDYKRRHPAFASRGSRTSLRSLLQEQDEDENEPAQSAHPVHPSQATAPIMQHPQVQPHLQQPAPVMQQPQQPIMQHPQQVQQTHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXG0</accession>
    <name>K1VXG0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase Sch9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXG0"/>
    <dbReference type="FunCoup" id="K1VXG0">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXG0"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_52_3_1"/>
    <dbReference type="InParanoid" id="K1VXG0"/>
    <dbReference type="OMA" id="EMRVQIT"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="150"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="363"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="623"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="745"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="788" mass="86462" checksum="84B91454DCF87817" modified="2012-11-28" version="1">MLKGVKLWPSSAQAQQPQPSKDAGDSDSLAPSSSFLGGPADQATPRASQTANPFDTMSAHQGSNAPTLSKATSALSLNAPNSPANGGRTPTTVGFGPIGTPGAAPATTGVTIGDTMGGVGGLGFGLHEPPKMLKAINTSSGVSRSMDGATTPTSADQPQTPSQSIRGTLNVKLIQARGLAVQKHADGEDPQPYVVMQFEQNEFVSRSPHPVSNPSHVPFTQSQPQPVNRATSGGLGSITRAFSDAIGRKKSNDGNRTPQPGDQQQVGSWFGKPGPGDPIWKEEVTFDLTQHTSQLSVSIYDRNKAGEGFLGMLTIKPTLRDGFTTDQWYKIGSRESEQVTGEIWIQTTFHATRNKVHLKPSDFDFLKLIGRGTFGRVFQVRKKDTKRIYAMKVLSKKEIVAKKEVAHTIGERKILQRSLECPFLVGLKFSFQTEKELYFVTDYKCGGELFWHLQKEGRFSEDRARFYIAELVLALEHLHKYNIVYRDLKPENILLDATGHIALCDFGLSKPDLTNDQLTNTFCGTTEYLAPEVLLDEKGYGKHVDFWSLGVLLFEMCCGWSPFYAEQTQEMYRLICYGKIRFPKHVIGDDGKQFVKGLLNRNPQNRLGAKRGAAELKEHPFFKSIDWDALYKKQITPPFKPIVDSDESVANFDPEFTNSTLAEAGVDIYDDDHYAGPEPGRHQYVGPGGSLSNPSYMGQAGGMAINKSQRPPAQNINGSPLTSSVQENFRGFTYTGESLVPASFLADQGMGDVEEEDNEEAVEDDDEYSDEDSMDGQRTRRQSDVDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXM4</accession>
    <name>K1VXM4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXM4"/>
    <dbReference type="STRING" id="1220162.K1VXM4"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556370_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXM4"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="9">
        <location>
            <begin position="55"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="172" mass="18625" checksum="7D5546BEE187E617" modified="2012-11-28" version="1">MKHQTPPPPTVPAAIKSADEAKASGLQDGGKPYSEFTESDVHTVEVATFASGCFVCTGRTNHAEGVRLQYQKGAVGYGELVEFFYRTHDPTTLNSQGPDFGSQYRSAIFYHGAEQEKIAKEVTQQVQEKYTTPPATSAPPTACTGDRISTASGRIELDLNIERRSLAGESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXU3</accession>
    <name>K1VXU3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_00335</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXU3"/>
    <dbReference type="FunCoup" id="K1VXU3">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXU3"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025461_1_0_1"/>
    <dbReference type="InParanoid" id="K1VXU3"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="14">
        <location>
            <begin position="271"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="273"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD05376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="460" mass="52553" checksum="1421E69549B6042E" modified="2012-11-28" version="1">MSQPVRKGNGPASATGNNGRKLGFPMMSPHEIFSCLGLLGINCQMDDITRPTAASTQAIWAGLLEVLCGVTQPQIEDSKSAIISKMEYRELYNGGLGIIMFLRLCQNLADRCGVPLTLPDLTRPDALRLRTALSGVLNYAKFREENLGLADKLQAQLDSDKERVIHLQRKIDKLDVAIEDCKATQEEDQPKVESARKRNEEVRNELRGLSEEQRQLSGEYEKMKQDRQALSKEGKERAALLESIDARTKEAKSRLVRSPDRMRKNISEMGSQVASQKEELSRTTEKLHEHTKRLEVLQSLETELKRLITLGKMIASQQETTEQLRREKERLQSAVDQAKAEGERLKERNDHLERQISFADEKLTRQRERIKEYHQSSKARIAELTAEYNQKDKERASLEGQLVELQNEEKQLRNEMKEYIAKNQAEIRKVLEAYKALRQRADSYIDQVANALGISQQIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYY4</accession>
    <name>K1VYY4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYY4"/>
    <dbReference type="HOGENOM" id="CLU_1332760_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYY4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="22559" checksum="25F118E0F70314A8" modified="2012-11-28" version="1">MPAPSPPAPQPQVPSTDNPTTPRADCAADQAGGASPPYTTPPDIPPSPAPDHSRSLTPSPTGQRGRKRRRRSSDSTSSLLDAYRSFTPATFYNEFIPYHLRRKTRHRGTQDPLDNATSQRALEPNNSLVDAFASGSTDLTTRQKVPLRDRLSLPCHVPGQKQLPPQPAKPARPNAKTRRRRAHLLAGRTAPPSQRPLRDRLSTPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ22</accession>
    <name>K1VZ22_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_00871</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ22"/>
    <dbReference type="FunCoup" id="K1VZ22">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZ22"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="InParanoid" id="K1VZ22"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="76"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD04817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="479" mass="51924" checksum="030E766F53206BBE" modified="2012-11-28" version="1">MSAPPPSTGQTPAIITQAPPPATTRESRIATHSHIKGLGLADDGTAMETSQGLVGQRSAREALGLHLDLLRQGKHSGRPLLLVGPPGTGKTALAVALSQELGSRVPFCAMVGSEVYSGEVKKTEVLGSAFRRAIGLRIKETKEVYEGEVTELTPSEAENPLSGYGKTISHVIVGLKTVKGTKQLRLDPSVYEAIQKERVVVGDVIYIEANTGAVKRVGRSDAYASEYDLEAEEYVPLPKGEVHKRKELVQDVTLHDLDMANARPQGGQDIMSVMGQLVKGGRTEVTDKLRREINKVVDRYVEQGVAEVVPGVLFIDEVHMLDMECFTYLNRALESPLSPYVVFASNRGICTIRGTDDGPGVMAEGIRSPHGLPVDLLDRCMIVKTEPYARDEIRTILETRCRVEGLSVQPAALDQLADEGTKSSLRYALQLLTPAMILAKTAGRSEVTTDDIGELNGLFLDTKHSTAMLKDMDAAEKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZA3</accession>
    <name>K1VZA3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZA3"/>
    <dbReference type="HOGENOM" id="CLU_055175_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZA3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="374" mass="42826" checksum="FA9A887FC04D7799" modified="2012-11-28" version="1">MPSRRDHRGIAAFPAFPVEILSEIFSHLDPSSVRRVLCVNSLFRTLARPLAYQYGTVTNLGLFFPGAQHVYPYSRGPGPSLPVSELSMEEQETLFAQLKRIDITAHPPEKCDEDSTSLSLNTPTPYFEPQVINLELNSCSHDDGKPTDYCQLVDELLHAVGNPTKLVIRGFPSCVYRIHTVEDYTYSPDVHVCVLYSQFSRRTEENQNCGTHANLGSNELSSLPGRHIQVVFWTARPGQAWLPPCEHYEEHRMSGFDYGEERTVWRSLAISTVYYRVQRVTVVNAAAVLPRTSFIEQHELKLKSYQAQLELQAAHSAWFQKELVYKAVSDNRAALEARQEFLTMEEWIKRGGWEDVFTPEEMQPWLRKMRGENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W125</accession>
    <name>K1W125_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W125"/>
    <dbReference type="STRING" id="1220162.K1W125"/>
    <dbReference type="HOGENOM" id="CLU_627289_0_0_1"/>
    <dbReference type="InParanoid" id="K1W125"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="437" mass="47003" checksum="B50C6C01996D1229" modified="2012-11-28" version="1">MRKSRPSSPLPPAPVQLPRASTAPSTPTTSTAGTTSDKENSKDNSKDAPRPKHKRIFSLTRQVPEQVAPHAPTVSVEKETAASKNGREKEKDTDAISPAAPDMTSTSVSTTKPPPSAAPSASPAHAPTLALLNGEGTFSHKHSSSLPTTGILSTPPPAASAAPTGLTKTPSPEQPQHAPSQPPSARSSTIVVSPSLPSNLANLSVAEDVSRRSSFRHMFRRTSKEHDKKDKDKRTPKKHHAWGHHSKCPEKCADAHSSREAFSDEDMSPTSLDSSIDYESAFKAVMLENIKLREEIAELRRRASLPLSTVTSRSNHPPNSSYDIGTTTGTMLDIEASSPGGPMELEKSVRELTNAIRAVPGRILVIVLIAGFVSIIRSWKFDSKRYETHSNEFIARIDVGFARLGQSSASGRTITSPPSAVLSPTRTEQPHTIQWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W295</accession>
    <name>K1W295_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W295"/>
    <dbReference type="FunCoup" id="K1W295">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W295"/>
    <dbReference type="eggNOG" id="KOG3337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_0_0_1"/>
    <dbReference type="InParanoid" id="K1W295"/>
    <dbReference type="OMA" id="ESYGANK"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="234" mass="26387" checksum="9AE8E5F85D0DE79C" modified="2012-11-28" version="1">MVHFYKKTHTYDEYPPTPLLAFFLRYPNPFARHVLCVDVLSRTIDPHTGQIRTLRLILKRGLVPAWASKWLPLPSGSGGRGLDAWVLEESVVDPPGWGFDGTPEEVAAKREEARRRREKSKGKMKEEDEESYLSQPRLKSTQGNLSHKKFMHVVEGAELCSGREGTTLHHTTAEVRSQFGGSWGKLIRDKIESYGANKLPGNTDRAREGMSLIMGLLRRREKGQPTDTPEPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2T9</accession>
    <name>K1W2T9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MSH2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA mismatch repair protein Msh2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000262">
        <property type="protein sequence ID" value="EKD03208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2T9"/>
    <dbReference type="FunCoup" id="K1W2T9">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W2T9"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_10_2_1"/>
    <dbReference type="InParanoid" id="K1W2T9"/>
    <dbReference type="OMA" id="KLYYAIL"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000925">
        <property type="entry name" value="DNA mismatch repair protein MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="672" mass="75577" checksum="38E3E44AC692E3B1" modified="2012-11-28" version="1">MSALAALISYLELMMDTPMHGQFHLRRHDLSQFMKLDASAVKALNLMPQPELGGNKNMSLYGLLNHCKTSQGQRLLGRWLKQPLVNRHAIQRRQDMVEMFVNDSVRRRTLQDEYLKRMPDFHRICKRFHRGGAGLEDLVRVYQAVAVLPKIIDSLDDLAKEEGMHGQVLEEDFIVPLREKATQLEQYSALIEESIDLEELEHNHHYHLQPTLDPELQQFRDSLLATRDGLDEEHRRVGRKLGLDIEKKLHLENNQVYNYSFRVTKAEANAIRQNPWCIELAVQKAGTIFTTEKLKELSAEYLRLQEEYEKKQKYLIKEVVGVASSYAPLLEELDGTIAALDVLVSFAHVSANAPIPYVKPTVAEKGGSDVIVRGARHPCLEVQDDINFIANDHEMRRGNSEFAILTGPNMGGKSTYIRQLGVIALLAQLGCFVPADSAKLPIFDCVLARVGAGDSQLKGVSTFMAEMLETATILRSATRDSLIIIDELGRGTSTYDGFGLAWAISEHIAKNIRAFCLFATHFHELTAMANQMEWVKNLQVRAEVQPAPAGKSISDRQITLLYQVIEGHSDQSFGIHVAELARFPDAVVKLAKRKADELEDFGTEDDAAKMPKLDEGEVEQGTQIVKEFLAEWKGQSADGSEDEQRAALKALVEQWQDRFDGNAWVKSVLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4M2</accession>
    <name>K1W4M2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4M2"/>
    <dbReference type="STRING" id="1220162.K1W4M2"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052873_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4M2"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="10">
        <location>
            <begin position="329"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="427" mass="47014" checksum="81D466F1E6530748" modified="2012-11-28" version="1">MGFAYQSGHETTSNRHPPVPIEFDFIGPTTQRQAMPPKTKQPQQAKAKPGEKRKWTPRPERPASERLPKLYRALADQVNDGYFDNAKKTCRKSEWSRSARSARSLLAEYYMCSLLSSCIHLHPVRAACKRASDGGMPYRRKDELPRRGLELTPVLSLDESSVPAFQTLLFLLLHTDDYASALSLVLSRQSQELKFEHAYCLYRLQREREALPLLADLADEPRVAHLRAQLAYRLGEYEEAERLYDGLLADASQSEAEDIRTNVAATQTQTRFIQSEYREKLATPAVINDPTVTNRPQDVERDVPALPSGWAKGSAAPAAAPVVTQAEASSSAEAGRSAEKKKERAKPRHPLPKGVSLGDTRKEDPERWMPLRQRSSYVPKKGKKETTGLGTQGGFEKPAGGQKQGGGGGGGGGGGGGGKNKKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4M6</accession>
    <name>K1W4M6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4M6"/>
    <dbReference type="HOGENOM" id="CLU_2335139_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4M6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012000068" evidence="1">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="98" mass="10663" checksum="9AAA3AF922A40CC6" modified="2012-11-28" version="1">MRLSVFLIAAGLVSGAAIPVRNAEREMAFVRRAGLERERGVQARAAVQSTRATLEQDIVAAIHPRAPEPAAIKPNEALNPRSHSWDAVERGAVDIWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4X1</accession>
    <name>K1W4X1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4X1"/>
    <dbReference type="FunCoup" id="K1W4X1">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4X1"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_1_1"/>
    <dbReference type="InParanoid" id="K1W4X1"/>
    <dbReference type="OMA" id="WCICILI"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="218" mass="24507" checksum="006963A624762758" modified="2012-11-28" version="1">MSRDPYTDAKSEVEANIGNLITLLDSYERIKSTAPGSTSLSETVEELQTTLGLLETDLEDLEECVRVVEDHGDRWGLASAEVRERRIFVDRRLRTQVTAAASLKDLSTRYQDIEAQNEEVDRWEREEQQVGRQPRVGSSPLQMLMRQQDSTLGVISGTRQNLASQAGLIGQEVNEHNVMIEDLSSHVDSTQSRLTKVTRTLNDFIRKNEARGASPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1W534</accession>
    <name>K1W534_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01702</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W534"/>
    <dbReference type="FunCoup" id="K1W534">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W534"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="InParanoid" id="K1W534"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="35048" checksum="CEDCDF478371B702" modified="2012-11-28" version="1">MSASEPRIVDSHGQTLAPGSGANTGSATPSTAVPRPAGGAAGGAGGTFGVKTGLAQMLKGGVIMDVMNVEQAKIAEEAGAAAVMALERIPANIRRDGGVARMSDPAMIKEIIDAVSIPVMAKCRIGHSVEAQILQAVGVDYIDESEVLTMADDQHHIGKHAFKVPFVCGCKNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHQRAVMADIRRAAAMSDEELYAFAKEIQAPYHLLKETARLKRLPVVSFAAGGIATPADAALMMQLGCDGVFVGSGIFLSGDPAKRARAIVQAVTHYNNPQVLADVSSNLGEAMVGISVANEIKTGKEQALSQRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W685</accession>
    <name>K1W685_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W685"/>
    <dbReference type="STRING" id="1220162.K1W685"/>
    <dbReference type="eggNOG" id="ENOG502SBIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_900757_0_0_1"/>
    <dbReference type="InParanoid" id="K1W685"/>
    <dbReference type="OMA" id="MVETHKI"/>
    <dbReference type="OrthoDB" id="2576622at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="309" mass="33831" checksum="9D913E915E03ABC8" modified="2012-11-28" version="1">MESEDSIVLSDEDATGGSGRDTQRAARSVRDELTPDLSSDEDESDDEASDSDVIGTKRKRADESEDDSGAESGEEPESDSEEEVEMRLEESPLFSPLTTEYPQMCVVCPERVLKHEVMARVHLDSNAHKRAIKRWTQRIAAGNLPSTDPREIVEDIQTSLAASKAPKAKASKSKPAKTTTTTSSAPAPEPEAESEAEDSDDEDEAEAEESGEESDDEAPAPAPAPAVPEVEKKEGAKLNRRQRRALARVAEGKPVDGSSKERRKRHLEAKKRRKEAAKNKEAKTEAKKESKKEGKDGKKVKKARKSIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W756</accession>
    <name>K1W756_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W756"/>
    <dbReference type="STRING" id="1220162.K1W756"/>
    <dbReference type="eggNOG" id="ENOG502SBUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1677807_0_0_1"/>
    <dbReference type="InParanoid" id="K1W756"/>
    <dbReference type="OMA" id="AESAYGM"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="15988" checksum="5C3BD3A597C9F009" modified="2012-11-28" version="1">MSEQNKQEPSQISGQLKGMAEQAIGSVLPGATGDAWIESGQKLQQEGQVEVEEAKLEAKKDATVDSAKGKAKSAFGYVTGNQEMQNEGNMQAEGAQWKYKQANSDGIASVPVPSAEGVKGKLESVAGMVTGDQSKQMEGNARAEKAAWKDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W890</accession>
    <name>K1W890_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Barwin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W890"/>
    <dbReference type="STRING" id="1220162.K1W890"/>
    <dbReference type="eggNOG" id="ENOG502S6X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047639_6_0_1"/>
    <dbReference type="InParanoid" id="K1W890"/>
    <dbReference type="OMA" id="ELSISWH"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001153">
        <property type="entry name" value="Barwin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00967">
        <property type="entry name" value="Barwin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852763" description="Barwin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Barwin" evidence="3">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="154" mass="16883" checksum="56A6D0B6A3727935" modified="2012-11-28" version="1">MFAKTLLALFAGVVAVSAAPTEKRSAYFTDLAENKTIEGGRATFYNAAENQGYCGYYNNGDQYVVAMNRPQLDGDNMCGNYVEITNTENGQTQVAQIVDECPECKYGSLDMSHSLFAALVPGEDWEDKGVFPITYKFLPLDYQPPADSPVPVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8J0</accession>
    <name>K1W8J0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8J0"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_0_1"/>
    <dbReference type="InParanoid" id="K1W8J0"/>
    <dbReference type="OMA" id="RESINGW"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="100098" checksum="EA148EC41D034DC1" modified="2012-11-28" version="1">MTERSARSARSGFSQGAQDSVGAASTTAEQRALLADDKGSSIHSPAFTLRARILGEYGHHPLQDAGPLEVLADRADMSDDEAVGILLNAIKEHDKDPNFSQATMRRIKELVRGPSAFAPDPQWSNECKAQAAMIRYHSPYAEVRAVTDPVDDADVPVETLRAYVLGILLMGAVTSLNTTMDAMSNYLRLSTVFSTNNPGLSIGTTVMQLVLAPCGRFLAWVLPDWGITIRGKRISLNPGPWSVKEQTLATIMFSVVQGAASTYYVYLVQRLPQYYNQSWVSWGYEITLALSVQFLGFGFAGLLRRIAIYPTTMLWPSVLPTLALNRVLCQKGRTKGEQPVHGWHVSRREFFLVACTGMFLWWWIPNLVFRGLRAFNWITWIAPQNFALAVVTGFYGGMGFNPMATRADPSEIQQYASRVLAGLIIIALYWTNFAWSAYLPINAYEAFSNTGEHYNVSRIITDSHVDLDKYKTYGPAYFSASNVFSQGAWFAWYGMVVFSVLIKHWPLLRKCAAGQWATLCGRSTLYGEYDDAQTRYIRKFPEVPEWWFLLVLAISIAFGIAAVTAWPSATPWWTILAVLGVSIVFVVPSQILSAVANTSVPTTVLFRTISGVWFAGRPEAAMITTVFGSAFNTGASQYVMDQKMALYAKLPPRAVFRAQLIAVLLQCFVFVGLLHWMLHKYDDGALCESGSSHYICFDTSLLYANSIMYGGLGVPNLFKLYPLLPWCFLLGAVVGIAYGVIYRCAPAIHRWAERRCPTKVYDRLHATCVSVSWMEWFDPAVSWSGALNWTGGNNLSYATNKVVLSFLFMYHIKRRYPAWWSKYNYILEAGFDAGAACAAIIITLVFDFAIHIDLAWWGNTVSQAGVDWQLWNGNASLLPIPDKGFFGLPPEQYPMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8Q4</accession>
    <name>K1W8Q4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000142">
        <property type="protein sequence ID" value="EKD05153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8Q4"/>
    <dbReference type="STRING" id="1220162.K1W8Q4"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="InParanoid" id="K1W8Q4"/>
    <dbReference type="OMA" id="FCEDIGE"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD05153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="321" mass="36866" checksum="055289BADE6FC9CE" modified="2012-11-28" version="1">MDYSKLRSQLKQDSAQRWSEAQEKVLREPYEYICNIPGKEVRSRLIEAFNLWMGIEEKDLDTIRRVVTMLHNASLLMDDVEDDSELRRGVPVAHAIYGVPQTINTANYVYFLAFQELLKLRDENGTDDGGHDLASMVTDEMLSLHRGQGMELFWRDSLTCPTEEEYVQMVLGKTGGLFRIAVKLMMAKSKKPRVDYIPLADLISVFFQIRDDYMNLQSDQYADRKGFCEDLTEGKFSFPIVHGVRADTSNRQILNVLQKKTHSDSLKRHTVEYLKNTTKSFAYTRQVLDELKGQIEAELKELGGNRGLDAIMAKLSYPDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9E0</accession>
    <name>K1W9E0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9E0"/>
    <dbReference type="HOGENOM" id="CLU_477503_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9E0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="571" mass="64389" checksum="67405C89978E6C8B" modified="2012-11-28" version="1">MCDYEVHPRFDNIPMATLPVPLPEADPGREALQLAPLHPTKEKLSNSMENLAGVLSDIKAYAVAAGADEHVARLEKEIGLLICDLESGQRRFFPAVLPFNDALLDQEDPDAIVDAICDHLAEVTVVAGCYASLAAAHRDLAVFKDIYLDHLSPRALKTVYIGYTHQIDVTVEYLRAVEAITDAAPIAFEERTELIYFKFIDVDDVLSEVVDITVDISERPEVRRWAEQAMERSQPTEETEDLIRALWGENIPFELFFPTARVYQVGRKLDNPLSSRDRLDVLALACKPASRQSFWLASRDLDVFEAISDHLVDVTVANKCYPDAAAAQRDFEVFRDIWLDGISLRALRTLYLSYSHQHDITLEYLKAIGLIGPHDQPMGFGDRDEVIYFKMLDTSGVLEAARSAIDRPHCHQDAQDLLDSVWDGRVPFKASDPDALFYHGGRKQGNRLSSRDRLDEEGLSYKTAASQSLWLSSRGFANVKPTYFALLKQTAASIKRRRLEQRVGELFLGTLIRSPLSSFHRRPSDDLYNLELHESYVVDGTEEDEGDEDRQARRANPRRDRGAVRVDDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9T4</accession>
    <name>K1W9T4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9T4"/>
    <dbReference type="HOGENOM" id="CLU_408364_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9T4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852807" evidence="2">
        <location>
            <begin position="18"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="660" mass="69759" checksum="6923656B2D1A9696" modified="2012-11-28" version="1">MKLQVLFSVLFALAAVGAPVQAPPRALARPAKRDFNLKTHAAGDNKARRDVGFEDLDWSSLGANVGHDAPGQANAGPEWPHGKRVVPTVPVKSLKRDQLAPAQAAAGGVEQRKSKFRRSHHHRYPTYDTDWSTDTEDEFYRTQPMPPNAGAPATGVSNGIPPRPPRRRAPQAGPYRGGYFNGYDSDSDFWTDSENELLYPVGRPGTVPAAAPGAVANGGRPRHRRRAVVPAESPNGGVPGHVAGNNAGFPDHDHPAGAPVPPGLPTPAPIPMTGARNPGRRQRIPPNSQQGAPTGPPAPNSYDSDGHLRYNSSEDESRFAPSAAGAGGRPLRRRQRASPSTQQGTGTGFHAPNSYDSDGRPRYDSSEDESRFPPTASAGRRPPHRRQRMPQQSGGTGRPHPNDYDSDGNPRYNSSADEARVAPSVPGGGRRPPHRRQRAAPFTQQAGAGNGSLVQQPGVTNGSAFRQPNSYDSDGNLRYNSSEDESRFAPAASGGQRQQPVFHAPNSYDSDGNLRYNSSEDESRFAPAAGGPRPPRRRQRVPHLAYDSDGPYYTTTDDEYGMRVPPPRVGPAAGPLPPAAGGAPPGAQSGGILSGLLSGIGLAAAKDTQGDGTSGNATVNAGSNGNATTKTDKAASMAASKRQLDPDFGLNGEDELPWCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA84</accession>
    <name>K1WA84_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000035">
        <property type="protein sequence ID" value="EKD05668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA84"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054441_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA84"/>
    <dbReference type="OMA" id="WIYAQAN"/>
    <dbReference type="OrthoDB" id="2594004at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854673" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="129"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="44925" checksum="2B8054C8DF456B17" modified="2012-11-28" version="1">MLSSVQLVLLATSVSAYPWVADAVEGRPLDERSLSGFWDTLRLGAKDISQSLGGVLKAQNDGKMKALGGEIKKGVDWIYAQANATEGFEGWPKPSLLDKSAADLSQELIYQTYNLDRVSNPPIWPIADEGHPYVAPGPGDVRGPCPGLNTLANHGYLPHNGIVSPDQLVRAVWEALSMSPDLGAILTVAGFVFKGDIDTMKLSIGGQVRGAGVGLSQHGTIEGDGSVTREDSALGDHVKVSQQRLQTYYGEIAKYGTNGYDINPTVCAESRYRAYQDSVQNNPAVDFSSTRHLIAYAESGFAMEVFRGANVSCTAETIDWFFNKEQFPPGWRRRNTPVTATEMIAWGMLFNKIKPTEPVRGLGIKGHPVKAGSSFLSEGTVKSNIEKFSGGLIKAVPKAMKYMAEALGQSGPLAGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAW2</accession>
    <name>K1WAW2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAW2"/>
    <dbReference type="STRING" id="1220162.K1WAW2"/>
    <dbReference type="eggNOG" id="KOG2605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472660_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAW2"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22771">
        <property type="entry name" value="OTU_plant_OTU7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="198"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="577" mass="62273" checksum="90946A10C222A462" modified="2012-11-28" version="1">MAVSYTKPGGRRRVAKQPSVGLDHSIPSTDTTLSPEHNALTTRTGVHTTPPRRHTRQSVRISIVPPTPTPDVPTRECSPSTSPDTSPLFHTTHSAQSFMPRLPLGYDPDPALHGEGSSRTPASTSLRPPKRARLMNPVLPTPSLLIGGGKPRRQRRTGGAEPRPRATRSRRGSATPVSLESIAAESDAVRAEVVRLGLSIRKVAPDGNCLFRALSDQLWGDQSRHVEVRKRICDHLEQHPEDVGDFVAGFLDPRGNETYEESYARYVDNMRQQGTYGSHVELLAACKVFRRSIRLVLSQTSHTVEFESTSPAPKSKPKSDDADSEAKEGPETTTSGRRRRAKGADSAPVSVPDAKEGHSMLWLAFFAEAEHYDSIRKGSGSGPAEVPDSLAVPHSRDVSELARRERGDLPPEEPSRRSGGKNDKLAQVYASLPPNHGLSDEHVAGVLARVKGDIGEAVEILLEDIDLEAEAGSQSSNSSAHVEAMLSDKDAYRERLNTPSSEEYAASPSDSASTAPTSPLGSQSEREDPEPATEDDKGGHLLRSGRRTATPAPPSAPSSSGPSSGPTTRSRRRRAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB18</accession>
    <name>K1WB18_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB18"/>
    <dbReference type="STRING" id="1220162.K1WB18"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_5_0_1"/>
    <dbReference type="InParanoid" id="K1WB18"/>
    <dbReference type="OMA" id="TKGKRWD"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="228"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="498"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="728"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1118" mass="122659" checksum="D6AFFFCE4CA02DCE" modified="2012-11-28" version="1">MSDYDEFDDGFDADESFFAAIDSIEATATASSASTSTAPTTARAAPAVRPSITSILGTNSPFKPPSAAVARQTARVNDTHAESGPSRRAAALGVRPPRPHLPPAPPLAPSSDDFDDFNFSEEALAQIDAAGARGHQRTAIPSSNLNRGGRPFNRQNSFHQTHLNFHRENPYTKGKRWDRTAYAASGRRLDADKAKKKAKGKRNDDESEDEAPLLPDGIPPIDTFALRTAQLTPVFRWFPSGKIVFMAPTKPLVNQQIEACQLTCGIPHDAAAVINGSVSSVERDRLRVFYCTPQTLQNDLERGAIDARDIVLAVVAVSPYFRVLALTATPGNKVDKVQGVVDGLHISRIEIREAESPEITQYTNEKRVELHTIPVEGVVRDTMRRWAELMHPLLKRLVDKNVLTPRDLDATRLRPFTVQAKLMELGRHPQFKWIWGPMQQVRQMAAAMQHLLEYSLGTFHEKALQMSGASNDKGKKGNSRGGANALHNNREYQMLMTDVETALNEIKGGREGKTRADLHPKMKKTLDLDALNDHPGLLRPTRFVGQSDGKKAGDRGLRQKDQKQAIADFKEGKFNILVSTSVGEEGLDIGEVDFIILYDMPQQSIKQIQRIGRTGRKRDGIVHVLMTEGREDGNWEKAQQTHRDIQREILLNANLELFEDVERLLPPGDLPTCVEKEMPVDAWDPGAKGKRKQLAGASKLKAKRAPVMAVPEGAEGFKSVSAWLKEGTKGKRGKNSGLRDYDDEDSEGDGEQGSSGKTKSDRPRKARKSDKPKTAAELAAEAAAEKAAAAERERQEREELDNEAIDFFNTQGLVRAPPPGLFDSPPARSPSQASSSGIVWTPSPKRADHALPAESPSKSSPFKSPAQPNGKPNGTPLFQPTIDLSLDDDDEDIFKEEPPAPKASTLDKSMPPPPLPTKSSPYSPKVATPLSRPAQLVPASTPMTDSTEPTPFPVRTRRRIGIVGSSPDMSPAQSLQRLRRRGEAIVAAQDDSSPVAMRRRRKRLRGAYADHEMASGDESSGSENSQDRMFAGDFAATQAPRGYDQHAVYAAGLSTQACARAGLKFDRDGATERAAFLSKARKAVLLSDDERDRERDSEDEYEVGSFVCDDEDISFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB54</accession>
    <name>K1WB54_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB54"/>
    <dbReference type="HOGENOM" id="CLU_1644914_0_0_1"/>
    <dbReference type="InParanoid" id="K1WB54"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="161" mass="18526" checksum="4FCB60C58D10114B" modified="2012-11-28" version="1">MPSVVNPPPLAEPVVCHVDIEVVTPDYFIGESDSEIMAADAEDVNDLKEYSRRRFALQTRKNVVSWELNNILREIEDTERYIAKLRRELARLDSNDDSGHTLAHLDFFTKELVEQRKELKELDAKRQTLEVMLRDIFTRARVLQERRASLTASASDEAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB74</accession>
    <name>K1WB74_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB74"/>
    <dbReference type="HOGENOM" id="CLU_331810_0_0_1"/>
    <dbReference type="InParanoid" id="K1WB74"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="866" mass="92579" checksum="BB5BADA052877A97" modified="2012-11-28" version="1">MVVRDMFRRVKNRRRHQLPEGADVITPFPFDLHDLQHSGQCSVPTSHEDSSQPPVMDTQSSTSDRPAPGDPSRAGAPPVCAATELSDRLAVFHRPADERPVGPIQPASKWSAIGIQWSASCDMIDATSVRTSASSKDEARIELAPYLAQPSSAIFHKSDYYLTGLAFDPVPGYVQAVLRPGQRDPKGSRDGREPISTSSPLLAPQPRRDSLADFLIQHQGFVGRGTPTPPSEPSATSPSLSGIDDDHPSHSLGSPPTSAGDLPGKESGKENEGPDGRLNGILRAGRGGNTEAVGETIRRAHDLGAQFLSAQVSQACQKIRAAPFGAGLSTGSSPLTSNLLGSSKHFGAGFDVSLGDSSIQHQCPAPAVAPANAFDPAVAQQKSVYHAVPTKSTRVALSPAAAFQLYWIHLEKSNSRAIDLYALPLELNSPNPTAVPSLPSSFGRSSRRSSRAAGNSDHQRDRRASGATDRSQYSQGYASYFSYGSCGSLSANGRTQIHAAVLRNPSGCGQKDVPKLGHGESSFGQPMQTIIGGFDNTNPAPKPAGKRRGLPSGLMMTPIEPRQEPRPVVRQPSGHRHRGAAKVPYTDPSFSSFRHAPPRQNSAGSQVSRARSKGHSSASHHSETQDVPRRPSAGHSATSHSHSAQLGSRRPSAATTSSLHPCPSASAMRRPSASGSNFSRPSVGAGSARRPSAGAPFAQHHSAVAPSASRRPSASTAPENSGSRFDNVYEATNGRSRSGFRPSAYSAPRRRSSTTAPAPDKEKPVYTRAYLKRFTRYPLPKAPIPADFQLPTHGFPRFCEGRKSDGQNCWNFCLKWSPREDALLRCLYCEQFIPREEEEDAYAAYAAAVAAAAKDNRDWETSTRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC28</accession>
    <name>K1WC28_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC28"/>
    <dbReference type="HOGENOM" id="CLU_1732779_0_0_1"/>
    <dbReference type="InParanoid" id="K1WC28"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="151" mass="17392" checksum="90E2928964359832" modified="2012-11-28" version="1">MVNDEQTALSRAFAALSPFSSSRRIPFEKKPWVQEAKTWETTWKRKPGHITLYMRFGSKTCSFLCSPEIRFESMKEPQVVHLARHVAFVSDRLPDEGTVKEYEMEEGDIIDIYYDRPTAGRAHRLPPTSLSRLLLYCTSRKALSLSRPPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCG9</accession>
    <name>K1WCG9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCG9"/>
    <dbReference type="eggNOG" id="ENOG502RXPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1027401_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCG9"/>
    <dbReference type="OMA" id="WPWRSWL"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="3">
        <location>
            <begin position="122"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="271" mass="29325" checksum="78803C55E7DA9F34" modified="2012-11-28" version="1">MSGNFRPPPSRRGSADAGPSLPNTSILRVLTNTQNASAAVFGVFFTAHLAAPIAAAFGGLEAADNVMILGRELYLPLETALVYAPLAIHVLSGAARRLFITYKTKGKARVSNQSKAGWILIPLVLPHLWLHRVLPAEAAAPINAMSPSEFGYEFAGYAARSRPWMTAGYLALTTFGVYHALIGGMQVVSWIKRLAGVKPKLKAVTFNEPEEIKERRLNRTLKPIYTLVGGVVAVVALGLFRMAKDTDALTASTLLRYRAIYESAPWSAVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCY1</accession>
    <name>K1WCY1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">lactoylglutathione lyase</fullName>
            <ecNumber evidence="4">4.4.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_06225</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WCY1"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="InParanoid" id="K1WCY1"/>
    <dbReference type="OMA" id="QQPPIFN"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="902"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="972"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1034"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1103"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="18">
        <location>
            <begin position="1180"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="1322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC99493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1333" mass="145340" checksum="80AC1CA95FB409B2" modified="2012-11-28" version="1">MVDKDKDAKDSLSIKSGRSASAETILPEVAYEIDAEKATHTGASGQQAHPQFAIPRSVTIQDDETAQRELRLRRQNSVGAGPRQVDTTSRLVGEFRTLSIHVTDSLRHPEQTEAKRTAVRELTELDWHKLDDKEVCQRLNVSPKAGLDRDQVKRRLNSSGYNEMTPPSNNVLMKWFWYVFGGFGTILFIASVLCFIAWRPLGDPNPSAANLALAVVLLIVIVIQTAFNAYQDWSTGKVMASIMNLLPQQVTVLRDGAQVQIEGREIVPGDLVYISLGNKLPADVRFLQTSSDFRLDRAVLTGESEPIAGVTHTTDDNFLESKNIGLQGTLCVGGSGLGIVIQTGDNTVFGRIAALSAQGGPALTTLQREIAHFVWIIVGCALTIALIIIILWAAWLNPKHKGFMSASTLVINVVSVCVAFIPEGLPISVTVSLSVIARTLAKNKVLCKTLMTVETLGSVSVLCSDKTGTLTQNQMTVTSVAVFEDEMDSLAARDRIVAQHDSADSVRQLAAVAGVCNAASFDASTLDQPLGLRKVHGDATDSAILRWAEFLRPVSESQSEWTEIFKMNFSSKTKFMLKLLRPSSTGKLTGNPAPVSQYEAFNDGDAILLTKGAPDVLLKRCSSINDASGGPSLPLTEQRRAQLVAVQERWAAKGQRVLLVAKRVIPASQLSGWDTASDEFADHVNLSLNQDLTVVGLLGLVDPPRPDIPDTIRTLRAAGIKVFMVTGDFALTAVAIAEQCGIVTARRRATLADLPRQAPELHGGLPDIGKGCEPVDTLSTEEAVLAPVDRALVLSGSDLMQMSEDQWAQACTYPEIVFARTTPEQKLRIVKEFQARGAVVGMTGDGVNDAPSLKAADVGIAMGGGSDVAMEAADLVLLESFSSMVVAVTYGRLVFDNLKKTILYLLPAGSFSELTPILICVLFGLPQMMSSIDMILVCCLTDVLPAVSMCFEKPETGLLLRPPRDIKKDKLVNWKLLFHAYAVLGVLESLCAFSMAFWYLQRAGYPFSKIVFAFGGLPPDLDADDFNEQVARAQSVYFFTLVFMQWGNLLATRTRRLSIFQHNPFWGPARNLFVPCAMAASIAFLFFFSYVPFFQKAFVTRGVPVEYIFIPIAFAVALLLLDEARKYCVRTWPKGFLAKIACSVVRSVAFGNLGWGDRIRLNAAGPLAGAPMPRQVPHQGPQGVLEGKLHRSGLADAQFYEEVLGMESDGGDFTNYFLGYPSGFGDKANASKEVKGDNFTNREGVLELCHNWGTENDPNFKGYASGNEEPGRGFGHICIAVDDLHAACKRFDELGVKFKKRPEEGRMRHIAFIYDPDGYWIEILSRKPGQEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD45</accession>
    <name>K1WD45_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD45"/>
    <dbReference type="FunCoup" id="K1WD45">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WD45"/>
    <dbReference type="eggNOG" id="KOG0359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="InParanoid" id="K1WD45"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="548" mass="60180" checksum="AB7ED436F62A9E02" modified="2012-11-28" version="1">MSSLELINPRAESVRRQQALQVNTAGAVGLANVVKSNLGPRGTIKMLVDGSGQIKMTKDGKVLLSEMQIQNPTAAMIARTAVAQDEQVGDGTTSVVLLVGELLKQADRYISEGVHPRVISEGFDIAKKASLEFLDQFKQYPTLDRANLIQVAHTSLSTKLHPSLAKKLAADVVDAVLAIRPPAPEPDADGKVGRRDPIDLHMIEIMKMQHRTDTDTKLIRGLVLDHGARHPDMPKRVENAYILTLNVSLEYEKTEVNSGFFYSSAEQREKLVESERRFVDDKLRKIVEFKNNVCDVDVKSGEKPKGFVIINQKGIDPMSLDVLAKNNILALRRAKRRNMERLQLACGGVAQNSVDDLDPEDLGWAGLVYEHTLGEEKYTFVEDVKEGKSPNAHTMTQIQEALRDGFRAVKNAIEDEAVIPGAGAFEVACSNYLENTVKSKAKGRAKLGVSAFAEALLIIPKTLAANGGYDVQDAIVQLQTEQEETDDPVGLDLRSGEPMNPVTEGVWDNYRVKRQMLHSCSVIAVNLLSTDEILRAGRSSLKPDGQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE04</accession>
    <name>K1WE04_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HDEL sequence binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05803</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE04"/>
    <dbReference type="FunCoup" id="K1WE04">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WE04"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057784_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE04"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="203" mass="23538" checksum="102D90EA04201519" modified="2012-11-28" version="1">MSHLASIFLLLHKMITSRSARGISFKSQALYLLVFVTRYLDLYKFYSVYNTLMKIFFIASAAYTIYLMKVKFRPTQDPSLDTFNVAYILGPAAVAALLFTHQYNFSEITWTFSLWVESLAILPQLFMLQRTGEADNITTHYLAALGLYRGLYIPNWIYRYYTETGQFDWRPVLPGLIQTALYADFGYIYVTKVLKGEKFELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE61</accession>
    <name>K1WE61_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate carboxypeptidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000356">
        <property type="protein sequence ID" value="EKC99908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE61"/>
    <dbReference type="FunCoup" id="K1WE61">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WE61"/>
    <dbReference type="MEROPS" id="M20.005"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="InParanoid" id="K1WE61"/>
    <dbReference type="OMA" id="CNVKFMI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="210"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="478" mass="52566" checksum="9AB9D0388162265B" modified="2012-11-28" version="1">MAANPDFLKYVDEHQDDFIQRLKSAVEIPSVSGNLQYVKDVENMADFLVKELTDLGVEVKKCPIGEHEIDGEKVALPPVVIGQIGNDPKKKNLLIYGHYDVQPALKEDGWDYEPFTLTPDPSGSGRLYGRGATDDKGPVMAWLNVLDAHKKLGLELPVNLKMVFEGMEESGSEGLAEFIHKEKDGFFANQDCMCISDNYWLDTKTPCLTYGLRGICYFEVCVDGPDRDLHSGVFGGTIHEPMTDLIALMSKLVTPQGEILVPGIKELIAPVTADEQSKFEKIHFAISDIQGAVGGDQTLSDDTVKTLMGRMRNPSLSLHGIEGAFYAPGSKTVIPCSVKGKFSIRLVPNLTVDETNKLVEDYLQAEFKKLGSKNRLKVVSNHGGEPWIADPNHYSYRAAHKATQEVYGQEPDYTREGGSIPVTLDFANELGINILLLPVGRGDDGAHSTNEKIDTSNYINGTKLLGSYLYELGAIPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE79</accession>
    <name>K1WE79_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hypoxia up-regulated 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE79"/>
    <dbReference type="FunCoup" id="K1WE79">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WE79"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="InParanoid" id="K1WE79"/>
    <dbReference type="OMA" id="HFINTTH"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854742" description="Hypoxia up-regulated 1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="717"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="85833" checksum="B2F8016C557EFECF" modified="2012-11-28" version="1">MRLHQCLLLLFALLSPLVQGAILAIDYGAEFTKLSLVKPGTPFDVLLDRDAKRKISSVVGWKKNDRVFGAEGKMSPLIAATEVPDLPIYPNPPLLTDDGSLIFKHANVPDHIKPAPSADAAWTPVDLLAHQIAAPAASRRPRGGRGREGTSERVTPKSKHFINTTHVEALAVGYEHVGAVNLDIATRDLIQDAFVKKTSRPDVKDDARAMARLSKEAVRVKQILSANQEAQASVESLFDDLDFRGMISREQLEDKMAKKLPEFTAPIKNALKDAGLTIDDITSVLFFGGNARVPMVQTAVRDYLGGKDDKVAQSVNGDEAAVLGAAFYGASISRQFKMKSIEIDEHSSYDYSLAGDVVFPKGTVQGERKTLLLKPEDKLDLVFEQSGTPILEVNIPDISAALANFTAPEPVVNLTLRLDKRGFFSVAQAALTSNQTDVPEKAKGVLGGLFGKKDKTETSADADAETEGAENKTEAEKAAEKPKKAPRVILKYTSKPLFKTMSKDEKRITKERLASIGVYEAALRAREEARNRLEAYLYRVQNYLSDEPDSKALFDFGTDEERERLSSGVASAFEWLHEYAESAPAGDLVSRLTELEALEAPIALRYTEWMARPTAVDKFQQAMHAGRAFLLSATENRTEALKAAESATDENPVAPPKYTEEELLKVANMLKEYEQWIDPLMTEQVKLNGDMKADPVIFSKDLDDKGKTLQIYVQALEKRKDPRVPRPKKKAPPKEDTKLKAEEREEQPEVVVEETEQKVFEEPVREEQEIKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH75</accession>
    <name>K1WH75_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenosylmethionine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH75"/>
    <dbReference type="FunCoup" id="K1WH75">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WH75"/>
    <dbReference type="eggNOG" id="KOG0788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023050_0_1_1"/>
    <dbReference type="InParanoid" id="K1WH75"/>
    <dbReference type="OMA" id="RNWHIYS"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="493" mass="53337" checksum="07B04BE3207FEA68" modified="2012-11-28" version="1">MAVDHGSVVQPSAPEILNDDSFPGPFEGPEKLLEVWFAPSPAMMEARMRAAGKPSSAVREDGTRVRGLRCVPRAQWEEMLDIVKCKVLSVVQGEELDSYLLSESSLFVYPHYIILKTCGTTLNLHGLGRINAIVAEHCGLDSQWRLFYSRKSFFFPELQKGPHREWSHEVEFLESGASGHGYDGNAYYVGPINRDHWVLYLTSPDDSVLEGLEEAAPAATAEAVERPLQLPPPSGFCDQTLEILMTHLRPEGREPFFVPAGVEKTGHELGVDISRQLGIDALFSPDETSLDSFGFEPCGYSANAVIGTGLPESNGGYFTIHVTPEEGWSFASFECNVPLPAMSPSAWASQSGSPDKAAPLAIANGNGKEANGANGANGHEKAANGFAAQANGQGAARPDLRSLISRVVDIFQPNRFSVTLFVSTENDTSSADAIPTDILGRSFTRRDKIGYEFEGYDLVFACFERKGWKEPKKPASAAGSMAGSVASIKALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJT1</accession>
    <name>K1WJT1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_04185</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJT1"/>
    <dbReference type="FunCoup" id="K1WJT1">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WJT1"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="InParanoid" id="K1WJT1"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="396"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD01624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="740" mass="85675" checksum="8286FAEAF4C9FC88" modified="2012-11-28" version="1">MGLPRGRCRPHHVAKLGMSYQYYILLYTSIYDYCTNSARGGLNLPQMPRGAGASLQGAELYKKLSQFLAEHCKSMRELNDLELLKYYARQWDRYTMGARYVNKLFNYLNKHWVKREKDEGRKDVYTVYTLALVMWKRQFFTYIKQESDTTPSRLTLAVLRQIELQRNGEIIDNSLLKKVIESYVALGIDDADAQRQNLEVYQDCFQKFFIDATEKYYTAESSAFVASNSVPDYMKKAEERLAEEADRINLYLHDSTRVQLKDTCEEVLINQHREIMWNEFQPLLDADREADLARMYGLLSRVRGLDPLRKKFEDHVKRAGLAAVERVVPAPGAVNEQGKPETLDPKAYIEALLSVHSKFGDIVNGPFNSELGFNASLDKACREFVNSNAAATTPTKSPELLASYCDQLLKKSNRDLDPDALENALNQSMVIFKFIDDKDVFQKFYQRRLASRLVNGTSASEDSESSMISKLKELSGYDYTNKLTRMFSDVSVGRDITEKFKEKERRDNSPDDIDFTIMVLGTNFWPLTPQNTEYNVPREIRGVYDRFTRFYNDVHSGRKLTWLWHVSKGEMRPTYLGQKYIFMVSAYQLVILCQFNENDSLTFKEIQTGTGLAEGILKSQLNLLTKLKVLTNDGDTYDLNMHFKSKKIRVQLNQPVRAEQKAEAKEVLQSVDEDRKFVYQANIVRLMKARKHQQLIQEVTAQISQKFTPKVSEIKKAIDHLIDKEYLERGEEKDQYNYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKA3</accession>
    <name>K1WKA3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1WKA3">
        <property type="interactions" value="561"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WKA3"/>
    <dbReference type="eggNOG" id="KOG1874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000511_4_2_1"/>
    <dbReference type="InParanoid" id="K1WKA3"/>
    <dbReference type="OMA" id="NQKLWLM"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1350" mass="149801" checksum="373F9235E4FA0AE9" modified="2012-11-28" version="1">MVDRKASTSGAFDRSSDVAKLSTALESWESGGRDTIAGVLLEQTKAATAEPLKQLNLFNSVITLLRSALSADVLVALFNDVFTSINENSASEAEALGSAVIDAIDEVILTESDSKDRQPEEFDSAILDRANILVKELAHVVNLVSSVENLSPLGLHPTPRDAQQLHRGYIKLQTSTYFKQRTSNLLREASEGFSHLIVLLTGPLVFSKTAKSSDEEVRQHAEDVWTRIQLIIGTFGLAPVRVLDLIIEIASCHVPTTWRFFRHLIGHFAQNGPRPLPHYDTEEERITHALDVLPDDDSTIAKTLGFRYLFYQNTDNGQTPTGLLVLTALLIKEGLVKPGHLLQKLSPDENGMEDILSRYKNAMNTRSGPSNALANSVLVDDDAPEGGEAAAEEEVEPEKPKAEQKIQLLRALLAIGESNMSLYLLAKYPWTVVANPALGQLIIRNIDYSLTPLYRRIVRGPGYSEVEGHTPEEVVQTLYTPVPPSTINKEFEFFYPTWMDELEQWSEIDDIHVRGERWLILLQGLGGRNSSLMIKIIRLMKHQLSEQLMEKVKNAVMEGSSDKEVKGFKLSLTDIKPWTGILRKVILPALSVADAASGAFDAELYELFELLDWDLLCSLFGEWRDSTTNARDRNNLPLAVHAAAQAQREVKGAMRRITAAAANPSGPPVPASQAAERGPARALAGIAHSNPLAFWTTANSQTMSYGSVGNIGEHMVEVGRYTNMLSKDIAVFSWVDTLGNVSQLSGKSVDYLATFVGLVNRRYAFPLDPILKMIATQLKFTDMAAFTVLEKLMNGMTGEDTVEEFAISNEQLESYAAGPEMVREAFFATENTRGSRKPLRSAELLDQVKKSGPRFVEALRSTGLAVPILVGLAYTAAEAPFLDPDAPLLTIQGQRDYTRNIFIRFCMYVAEVLTPQERINLIPTFTELSEEIGIEPQMAWMILRPKLAAQEDAPSGEAMDVDSQSEWWPSHLTGTIRELEVLPEYRPVKDVLGILAVNDIACATNQYDQASARIAKLLREVSKTSSEGKRLRARDDVLRKEKATMEKHVEEVRGRLQEECRNWFNSDVDQQREGLIARQLHDHCFYNRAVNSPADAMFVARFIRMAHDFGTPGFSAALAYSHFFSTGLSTRIYTCTENEARNLGRCLYLMLVDLDAWYLSESKYNLEALGTADGSEATLPGMQYRTKNADTKKTMDYDSFKNFYAKLHNSLSTSLKACLVSNTEFSPKNAIVIALQLLPFFPIMDTNARSIEDSVRKLVEGKLENKIGPEQVPAFKSYLNQLKTRQTQRPCVSYADFHPNGAKQFAVNQKRLAAKQAEEKAAAEAAAAAKAAEEKEEAAKAESEKDQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WN54</accession>
    <name>K1WN54_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WN54"/>
    <dbReference type="STRING" id="1220162.K1WN54"/>
    <dbReference type="eggNOG" id="ENOG502S342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048444_1_0_1"/>
    <dbReference type="InParanoid" id="K1WN54"/>
    <dbReference type="OMA" id="SHEWIEH"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30831" checksum="D862A770840CC50D" modified="2012-11-28" version="1">MPEEHDPTAHVMDYPALDLGNKECSKTHVAIVDLDVFVWGLEEIKDSKLPIAAVIASHGRCNSAKNMEPFARGLLAEAREQEKASGRRKIRDLVVVTLKADISDGATQDYDMIMKFLNPYLFPKGEREITEWMATGISLGGNTVWRLLREDPRIRVAVPIIGLPFEAFGPYLGARAVQGGLDFAPPIYPATLRPYIESREPESAYKDRKILSIHGEIDELVPYRFGKDKIAELKKNAPEGHIEVFVQKGKGHVCTPDMLRRAAEWFYRWGCTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNP9</accession>
    <name>K1WNP9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNP9"/>
    <dbReference type="STRING" id="1220162.K1WNP9"/>
    <dbReference type="eggNOG" id="ENOG502RB9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575130_0_0_1"/>
    <dbReference type="InParanoid" id="K1WNP9"/>
    <dbReference type="OMA" id="RATWACP"/>
    <dbReference type="OrthoDB" id="3153298at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="475" mass="51973" checksum="27AA6E8EFFD6D6F7" modified="2012-11-28" version="1">MASTQGRYVPPHLRKAQLNAGDAPPIANNRSPVPRSPAGGSKWSSSTPPSGGNDRRPWSDRDGAHTPRGGHHHIQRDPPPHQRGSSGPSLFVFGDSFVGPFKLLSDRYSKTQTFKGSSAKSLKQVSNELVPLLNRLLAPPPYAYLPPSGRYALLIFGNHKPLGPGTWSDVPAVAPAASEESETERILANATENEGRGPALGPERFVDTVLKAYTTWLEREVVNGPVGRRAAAIAAPDAPDNVRRLPPTKVLVAAALPPLVQDETLPRIPQKYVERLEADHVSAQRAFERGEKAPRSTTRLTPETIETAMARASLNESPVGKMTVQQLLVHDPPLCTKPVRIEMTERFNQGLKAFCEQHSNVLGYVDIAEAMHNVDSEDAKTMAANGATEADRLDREVSRATWACPVDPSNIHPLWEPTLPLWLKALKAQGVPTDQFAMSDDAEATFKAYEEDKRRRMNPAFADKPAEAVKIREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP44</accession>
    <name>K1WP44_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP44"/>
    <dbReference type="FunCoup" id="K1WP44">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WP44"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="InParanoid" id="K1WP44"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="6">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="7">
        <location>
            <begin position="211"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="57007" checksum="DEBDC6920A9BC750" modified="2012-11-28" version="1">MRPPFTRTAGSLLRRQAPVASSSLLSSSLLSRRAYASAVAAEVPAQVTTLPNKVRVATENIPGHFHSVGVYVDAGSRYESHKSSGTSHLLDRLAFKSTNKHTDDEMTVLVDRLGSQMTCSSSRETIMYQSTVFPQSLPLALELMSSTILHPNLLPEELETQKDAAAYEIREIWAKPELILPEILHTVAFRDNTLGMPLLCPESQLDVLGEKEIRQFMTDWYRPERIVVAGVGMPHEELVELTQKFFGELPAPPTTGLPPGVSPDFAQLASARATYTGGQEYILKPEEEFVHLYVGFEGLGVHDPDIYALATLQTLLGGGGSFSAGGPGKGMYTRLYTNVLNRYHAVDYCAGFHHCYADSGLFGIAMSVYPQFAQSAANVLSHQLDLLTRPQKGGITQIELSRAKNMLKSQLVMALESRLTAVEVLLDLAGLDRAQYWSRQIVYTLRSAFLPAKLWNHLVQADIQDLHRTATRVLRPSSRTVPLNYGLGSGEPTIVAQGQVEGLGDVAATLKAWGLGRQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRR6</accession>
    <name>K1WRR6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRR6"/>
    <dbReference type="STRING" id="1220162.K1WRR6"/>
    <dbReference type="eggNOG" id="ENOG502T2FQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520756_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRR6"/>
    <dbReference type="OMA" id="LQIAHRI"/>
    <dbReference type="OrthoDB" id="2592707at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="525" mass="58264" checksum="8944CCA39F2AC4F5" modified="2012-11-28" version="1">MSSVTPPRRRRIERTDFSSPRDTTEDAPGTPGPTKARIANLNSQVQELVRKHHAAEMRAQESAYEVKLEQRDIQLADVQEQLAAQERRNARITRELERCEAEGNGMREEQQKALLALSEERLQLIEMEQRLANAEAERVIRDHKLALFKSREADMMVASDRTSARIAELETANTSAAHQRAAETKSALDTTAALESQIKELQDSLVSLSAENEKLRSESAELQDAHKSLKEKEKLTRAELATAQAAAGGDEKLKKQLREVKAESAQHEQEIEELREQLESLKETNKTLKAKEKSARTELAMAQASSGGDDKLKAQLREVKAQAAKHEDAVEEAREELETLKETHKALKAKYREERPRSRKATPKDDSGSDSDIAPVRKKKVAKSPVKPRAKASPKPKSKARKASPVSDSEDESPKKKPKKAPVSAKEKASKPVSKARRPLAEADVNASDDDRSVRSSAEPEKKKKRKLFGAQPAFNWDPILSKPMLMDQSGDGVIPTFLSPVKSTRAVGTIPRAGFSKSSRLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSF2</accession>
    <name>K1WSF2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benomyl/methotrexate resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSF2"/>
    <dbReference type="FunCoup" id="K1WSF2">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSF2"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="InParanoid" id="K1WSF2"/>
    <dbReference type="OMA" id="WFESFAI"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="117"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="569" mass="63135" checksum="43E62595EC7B1E55" modified="2012-11-28" version="1">MARWSSFVRETTFGRLVRVFKPSAFPYAEEKPGFVVPTFQCDEDPKPPLPRAPGPTSPPSACSLETAVGDDDEKISWHDDRQTKLPVVPDGIKIVTWYGPEDPANPQNWSFRLKCWIVAVIMFYTFAIYAGSSIVALGIHEVAEEFHVAEIVATLSITLFVVGYAVGPLFLSPLSEMASIGRNPPYVLSLFIFFILQIPSALVDNFAGLCVLRFLAGFMGSPPLATGGATLADVFSDRKLGYAMGLYGVALGVAPATAPFIAGFAIMNKGWRWSFWIMLMIAGAALVLLFFGLPETNADNILYRRAARLRKMTGDESYHAACEITAKEKTISHELYEALVRPMVLTVAEPIVLAIDLYQGLTYAILYSYFETFPMVFGVGNEHWKGYGWNIGLSGLPFIALTIGGMASYVVYVIWSRVWWEPRFVRARREGRQLQPEDYLPLSLPGAFCYPICLFWFAWSANRTHWISPTIASAIFGLADCWSFIPYLSYMAIAYPNCPASALASNDFVRSIMGAAMPIVARPLFNNLGIDWGNSLMGFISVAFIPIPFVLWKYGPWLRAKSSRAATFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU46</accession>
    <name>K1WU46_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU46"/>
    <dbReference type="FunCoup" id="K1WU46">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WU46"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_0_1_1"/>
    <dbReference type="InParanoid" id="K1WU46"/>
    <dbReference type="OMA" id="YICLYAE"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="181" mass="19205" checksum="291546C804B3C1DC" modified="2012-11-28" version="1">MDSPTSRPPLRSDVHRCDTTVTPCLSHGFWTCLLLLAPTVTPPCRPPRAAAPDTSTSLLRATAYVDDQLLATGKISKAAILGKQGGVWAASSGYSPEQDFITQTAFTDPDTVRANGITLNGFKFMALQANDTEVIGRKGERGVFIIPTTQAILVGEYDGTAAGEANVVVSKLADYLKSVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUP7</accession>
    <name>K1WUP7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette (ABC) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUP7"/>
    <dbReference type="STRING" id="1220162.K1WUP7"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="InParanoid" id="K1WUP7"/>
    <dbReference type="OMA" id="PNENHVL"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="419"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="708" mass="78822" checksum="1021957DCD8131B0" modified="2012-11-28" version="1">MTSLPSLSFPQAERRRAAILIVVALALTRSAPIPALKELSDALSLKEWRETRKQRREERRRRERETPLNTPALEKKMVDLYIPDPSGSRTLLVPHRGVISKVRVTPTPASLYAEHRKLFPPLKAGEKLGVNKRFWQMLTAVLRIAFPSNNNLNYYKFGQGWGAIAPGRKDDTSETQAGGADQLITTDLSRFCETLAALYGNMGKPFLDMVIFTSQLAASLGPVGTCGLFAQYYFTAWVLKKATPAFGRMAATQARLEGEYRTGLGRIGRDSEEIAFYDGGKRELSILWKAYNKLTGHVHTIFKDFVIKYFWSAVGYGLMSIPVFYPVATQAIQGETSAAELHNEVASRTESYVSNRRLLLSLGDAGGRLMYSGKELAQLSGYTSRVYSLLASLHALDENRYPENPRPESLPPNENHVLLRGVPIVAPAGGAAGAERGGEELIRSLDLRVEKGEHTLITGPNGVGKTAIARVIAQLWPAWVGLLERPTQGEGGIFFLPQKPYLSIGSLRDQVIYPHTYAEMKARGRTDSELMDILKHVHLAYLPGREGGWDTRKEWKDVLSGGEKQRMGMARLFYHRPQYGVLDECTSAVSTDVEGLMYEHAKSLGITLITISHRPSLLKYHNRHLRLGEPTLHPSLSTANLQSALGTPSTPLASQGWQLTTLSSGTHEEKLELDKEIERLERMLGNDVGEWEKRLEEVNRELRGEAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVM8</accession>
    <name>K1WVM8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVM8"/>
    <dbReference type="STRING" id="1220162.K1WVM8"/>
    <dbReference type="eggNOG" id="ENOG502SF56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_593378_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVM8"/>
    <dbReference type="OMA" id="DEYYTHG"/>
    <dbReference type="OrthoDB" id="5550090at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="461" mass="47582" checksum="F7E7DDE47211A528" modified="2012-11-28" version="1">MPRKHRPRDTKIYVPASPAPQPPGSPSDGPSESGPSLEVLLMAQQIAHQRGHTFDIESFLTPEQRVEYAAIQGEEPPDVPSGSTSERSGEASGMSGVSGASGVSGEGHSNSGEGSEEGGAGSEGGIGTREREDEDVIGTPPAKRIKLGPNTPLSQVYWKQRLDRLARVRSRSFSPSSSPSASVHPHLPGHPSHLPPPSPARSREASPSPWARRELRDTPVHLRKLAPVTEADKVDIAASASYWNHLLCQARAARGPQYDYNTRQLLFDRQSEAYYTQGRPPREDTPPPEPAPEAPSSAASASASAGEGGKERPASKDGSQAEKKDAGKDKGEEKKDKGPPTPKPNGEQQPNGTPKSQPPPSPGPPHARLAAAQAAQANVQAQALALGGVGPGQESPGGPGGPGGPGGPGGMPPGMNPGMNPGMMMPQGVNPMALMGGGPPPQGPMVGGGQGPMLGGGWQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXI6</accession>
    <name>K1WXI6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prib protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXI6"/>
    <dbReference type="STRING" id="1220162.K1WXI6"/>
    <dbReference type="eggNOG" id="ENOG502TGN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414568_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXI6"/>
    <dbReference type="OrthoDB" id="2569636at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="662" mass="73380" checksum="EB398674510FCA50" modified="2012-11-28" version="1">MDSDSSPAESSRQHNQHRQRIPRPRTACTICRALKVCAANIVLHQLTAPDAMFARERNCTAGITVFKMCEAESRLPVLQGQERRNADPNAGPPSNSSTGSADQRVVRQRVDNNHGPPPHLPSHHDAPYDMKPMHSQPSHNNISPPNHPPHPTHQNIPTHSGHENHQNPPSHPLHTSHPPQHPQHPPAPPPPAYWDHPSAETVVSGPASSQPSSRAYDPVASHRQAPSPAAPFRPFTLALGPSPSADRNVTLENVLEPVLDTDSRRQSVENDRPNDSAAAPRPGPPVIHYPDPVNTGLFSELEARALFKHPSSHIFDPYYHTYERVRASPVLFNAVMYATCRFMRPELSEQCFDLAETVIGRMLRIGAATIPLVQALLALVYWKKPKDRTAYVKLGTAVRLIQQMRVEWPNEPRSFASEEQERAAVDVERTIYSELISLRGLVALYPYPPPADDPRIHTDYDGVVGLTVISSAIDDWMRNPNLRGVYRLLSGVLGKTMVLKMQVGGLKYSAISTEDVLGLAEEIGVVIRDIVAGGEPIYWSDMSCTMLSGMGTLMWAARNAFRVEDLARIERLCKDVTSAFETLPEHLIADHALSYNKRLYSRLGSAFERLCQGAQESQNDILNQLLSGGWSATANSNAPLLFNDMVPDPNQDWNWMFPVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WYJ5</accession>
    <name>K1WYJ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000004">
        <property type="protein sequence ID" value="EKD05699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WYJ5"/>
    <dbReference type="HOGENOM" id="CLU_2308027_0_0_1"/>
    <dbReference type="InParanoid" id="K1WYJ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="100" mass="11504" checksum="CFDAF012660F9BA8" modified="2012-11-28" version="1">MAIVTRITEALQILRARDKPRRDHLLSAPSMTETEEDWLDNVSNHTELAQLLEELRDRADPDNHYRRLQEDGRTGAIDAALLEADSCRTTPLPRRQQLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V015</accession>
    <name>K1V015_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V015"/>
    <dbReference type="HOGENOM" id="CLU_839886_0_0_1"/>
    <dbReference type="InParanoid" id="K1V015"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="38616" checksum="46AE65FB5FDAE58C" modified="2012-11-28" version="1">MTPSTSDTSFESIYASSQQTSKPLSTVIIDHLAFPHIIDNILANLDILGNAVASRVCSGWRIKANAVLQRHLTAVNKQDGIMLNLTKAWEDVRIERDLNKCKFQQLVKETPSHVQELYNNIQILDHRERLSEHHNSVNDLVACLELYGRNAITTRYNARSQIGDSYIETEGETQVLFLKHPVPCVRTIGARVVVVNLDCGSPALSPICGSFGEGHFEDRDEPLLSMEPDQPESLVIIFKHNRPHPPLDSDRALDFPGEVEDYALWLSRYLDSWFEPAKDLSTILVGLNDFFRPKEDLERFITEFFMHLPPDNRVEFLSRKEYQRRVGFETYRLHTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1S9</accession>
    <name>K1V1S9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1S9"/>
    <dbReference type="STRING" id="1220162.K1V1S9"/>
    <dbReference type="eggNOG" id="ENOG502R17J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440184_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1S9"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="66739" checksum="01F70731E89B6F5C" modified="2012-11-28" version="1">MAAMVEAPQRPAQHVHMQYEYANGMTVQDDDNSDQDIHAHAHLLGHGDDPMDRDMEEYYTQQDYQNLQAQQNVYNQHMVQYHNDDDADMDDDEMYSDESSEESVLPDENIDFSLVYALLLLLDDANSYWWLVRVLKTEDVGYIPAENVETPYERLARLNKHRNIDIAAPTELEKSTNPSQPRESKLKTLIGWTRRTSRGSLDSEEIENREGRRVIFAPPTYVDHPGVTWSSDEEDDDMEEDEQHFADDEDQELGYEAEPDDGVEWAQDAVEAIRSATDAPQTAANAGDTVSRTTVVAVAGAGVASTAIGAGIASTIVTSTSTPSSASDAETITVDSTRSAAAVAATAPSIVSGTDSTPAQNPQDAQAQPAPVHQAGEPTRQGPPAPTNQGDVVSETPASPTAPGAPAAVASTVTGLSTNAHPAFPPAPERSPSPARPTSLLARTNPTPPPHRAGALSVSPEFDSPALTARDMAAVTPPPPSASISEHPSTPQFTSAGSTETPMTSLSLTRNSPHTTPSTSPTDGRAGSSAQPRAPMWYLSASDVSRLATLVRIRAENEGVQARLTHLEESDEVQHSLYGEKVDTSFLHPDVRSGYVHLQAKLDAFDREIDAILGSLAVPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2T0</accession>
    <name>K1V2T0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07511</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2T0"/>
    <dbReference type="STRING" id="1220162.K1V2T0"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="InParanoid" id="K1V2T0"/>
    <dbReference type="OMA" id="QGMKGTF"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1078"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="14">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="14">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="14">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1102" mass="117038" checksum="7B205D2A76DC0F4A" modified="2012-11-28" version="1">MADIPTHLLTASLLVNNMHCPSCIDTIRAALTNVPSVHNLTVSLLLHRITFNVDSKRSASVIEHVKRILRTEGFSVATPDEPEEPESDELPTGFLGRLVGKRREVRAEKREEARRRQHLEHCEQCRAEALGVSEKKDAGTLKTTLSIEGMTCGSCSAGIASALEANPLVLDGNISVLTSSGVITHKAGITGDELVDLVEELGYGAKVIESVPEAPAGGDKLVTTTYSIEGMTCASCTSSIEAGLKDVDGIEKVDINLLNSQGTVTHRASLSDVSIKELIEDIGFGAEVVRTQDAEDGERSVTIRVDGVFCGNCITQLNAHLATLKDVRYTAFTMKNPQTTITYTPREPYTVRELVRGLAGVAPEFDAEVVRPASVSERSQAIQRREVKVLAAHLVAAVILAIPTFIIAIVSMVMLKMDHPFRRFWDTAVWGGANRGTIVLWALATVVQFGIGRFFYVRAYHGLAPHIRSLLAKFHLCSSPRPWTWRSMVSFGSMDLLVALSTTVSYFASVAMLAIDVRHPGRMSIGSYFDASVFVIMFILLGRTLEAYAKAKTTDAVALLGALRPATAWLVEDEKAEAREIPVDLVERGDILLVHPGALPPADGVVVHGTSSFDESSLTGEAVPVAKTEGDEVYTGTTNLSSAVQISVTGLGGDTMLDRIIAAVSRASKAPLEKAAETLTGVFVPVICYFSIFVLALWLGLTYGGVVDPHNQAGRAFFAIEFCVAVLVVACPCGIGLAVPCANAVGTGLAAKVGILAGGGEAFTGITKVTTVALDKTGTLTQGKPAVVAELLLAEDKEVPLATRALEATSTHPLAVGLTEHLSSLEGSVEIATSEEIAGRGLTAKTGSGLELAIGNDKLMADHDVDLADVTPMLEEWGAAARSVVLVAARRGEAPWALAAAYALSDPLRPSTAPILAQLQKRGFRVVMLTGDNERTANAIGKELGLKPEDVHAGLGPQDKADVIGKLQAESVPRKTWRGTKDVPNRVLFVGDGINDSIALSTAACSVAMGHGSQSTLASADFVLLSSDLASIPDLLKLSRKVVNRQWINLCWAMVFNVVCLPIAAGILYPAGIRLSPVWSAILMAASSVSVILSSLALRWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3T8</accession>
    <name>K1V3T8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3T8"/>
    <dbReference type="HOGENOM" id="CLU_365701_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3T8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="763" mass="85116" checksum="FE17AEFED12D6DC7" modified="2012-11-28" version="1">MKMMQAAELGFVHQLTCTSRLKAPVTLSDKFLLPLAKDEKEPPEPEERCLLRGYQAWTFDIPRIGDHGEAAERVAWNWLRSRIEEAILLSHTGHAYAEFIEYKWRPDNYQRCPPLVVTSDMVGPPRQFGPAGYQGQTLILYTAGKYKGEDPIKHTTLCDTWSDFIFRFEDPGTLKVKDRPRFLPLTHMVAAMVLDHRFTDDIAFGLFATFPSCVVKLAVHPLKCSIGLNDCQARESLAPFGPKTLENINGATVVLLACVVVNHPLACAKLLSFPRTGALILRDLSSNNVWGYITPENHLSEWSTRILDILWEGDISTSMKTWARSCSQLVASYVGRDTGSLYWWNNKVLSHPETLEPFPTAAVLCDALAHGQLLLPKRSGGAMEYLQNLALAAACTFGAVLSIVEAEIQKRERRTQNIQSLSAVAIEWGANFLRFVAIGGLSSLQVDLDATKGFFDKWLDDKQDAYASKMKEGLMDLWSQLQLLLETAFADAGQWDGSELDRKRCTAVALSFQTCFNKNLLLCLKSADPSDFQIQIDAFNSNSGLLDLLRDDPHYRDWLEPLLIRIHTTVFVSKTAPMRRPDVFRQPTRESWYGDSLRTQRYSGEAAKLNPCTNFLGLANPPRSQTSSSKLSHETLCLFILRCKSFYGLRTHAEGSPRKTVYNCPSGDGEAFAALGAGDCHLANTKQEVLPSRSASEVPEERYELTSAQSTTQMNAKISRVSALGGKEIPFSRGYHRSDKLESSAHSLHGALSTGTLNVRYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4Z4</accession>
    <name>K1V4Z4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4Z4"/>
    <dbReference type="HOGENOM" id="CLU_1887220_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4Z4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="135" mass="15719" checksum="419196F41722F3B0" modified="2012-11-28" version="1">MTDEGRPLNLEEGLIIYKDTTPETGILVWSVQNRRLPFLHGWVFSRRYPLAALVPPRAVERSLRSPIERYATMVPWTFDPRRMRRQDPGPPNDFPLTKRRSIMLYLGIGDALYPQRVYMDNSIYALKVRGNLANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1V597</accession>
    <name>K1V597_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V597"/>
    <dbReference type="STRING" id="1220162.K1V597"/>
    <dbReference type="eggNOG" id="ENOG502S3SJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605526_0_0_1"/>
    <dbReference type="InParanoid" id="K1V597"/>
    <dbReference type="OMA" id="PMASQDY"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="499" mass="54976" checksum="FC72EAB89F92A186" modified="2012-11-28" version="1">MALIEEIEDDKRRSPSPIKIEEITDEEDEKPRKPKVAPPPPAATSAPPAPVSDFQKKLQDLTSKMALPSDLLPAFMSEQAGKLLVDVSAQKLTSAPIVFESYKDQVQQCLARLFPLIQSPDWASLSFEEQASTLSQILRLRGNDAWTSLGISDMVDTSGVDTTELSRYILISVLRPLFSPHPYISNNRAVAKPLGGAEAMDDLQETSTYKTQNGWGSANLLHWSSSVLPPIQLEKQLNLILPPTLTMMDDWEPFWRLKGIWVLSGWLRNMDKEELKRRNLNSLLLKSLLHTLSLHAKDSGVVLDTIVGFLLDDFKGEKRADILNEIVDKACISAWSYASGEDAKAMLIQAAVDWETMCGVLGTGVARWLKAVIPSLLAPLEIPPMPSNLPHLKASLSALLATAQILKGTGRISRWRGQILNMVAKMWVMLCERWPEAGGADMVDDTNGSEKEQVAQIKSLARGICDLIADACPSVRASEFQSLLDMNKAMFTPLVSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5G6</accession>
    <name>K1V5G6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000374">
        <property type="protein sequence ID" value="EKC99194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5G6"/>
    <dbReference type="HOGENOM" id="CLU_1788181_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5G6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="145" mass="16081" checksum="9758759B18E98296" modified="2012-11-28" version="1">MGFCALRGRSGPVWPPSLSCLLRLLSTFAKNTLRSWITHLYHVCRHAHSAATATEPLSPAERPIHGLHGPPQQPPPDTPEPHFVPNQRSKFRQEAENSGLGTYSYNTGTLAASDVSDRSTRPFLWHPLSQSLDGNRIELYLVPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5K7</accession>
    <name>K1V5K7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5K7"/>
    <dbReference type="HOGENOM" id="CLU_726011_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5K7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="381" mass="40971" checksum="F079ED0528F1E167" modified="2012-11-28" version="1">MDGSYKFPSLSSLDHAKEVLANAGVHISTELAGDFKSGTMNGDGLGDYVLINPSTPGERQIPPNSYYAILKGPRSERQSDCWVVWDPKPPAAEAVQHSFGYSPQNYTDAADMSAVALDPSQSYTMRIFSQGNRPWGCLFQKLVVYQTTDQHSPLPDVTETHAPTIDATGSANGTSTGKSSSSSNTGAIVGGVVGGVCGGLILAGLILGCCWWRNRKQKQRTRGHTQNISSGSDMTHRSGAPVLRRWGSHTTVESLATSLDSQSKYGDEEHRQSFPDMALDDAVLPSQSPSTSGAPSFAHRTPSRTSYQHSSPSRSSRPTTASYATHYTSAQSHSSFGTQHPNQSTGSYEHNTTSYNSVRPSSEYENQQAMLTPSASGRRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5X7</accession>
    <name>K1V5X7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5X7"/>
    <dbReference type="HOGENOM" id="CLU_650831_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5X7"/>
    <dbReference type="OrthoDB" id="10633092at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="422" mass="46177" checksum="01C5627E3E26F406" modified="2012-11-28" version="1">MYRPVPLLDPTVTEALRPVMTRAFYGDDWDCVRLLSLLTEPDHEPVILEKPCGCCKESGSKCIASLRTEDPQYPFPYVPGRCVSCVLSGKKCDLPLRTKLPVCTCSWLLNPADRAHEERHAFLHRLSVQQACVPRNQQWGKSHRLTLAAKMRSHELKFTHKTKEALELSTDLLVGMAEVLGRQSPDLYRPDGTWVIPPKSEWQQCKCYPGKCRGHEKGKAIKKVRKLVDRDTLMSPPLSPTIMSPSVMSPLLKPVDCMCGGGLPLPMALPMSPSISNASLTSTILQTPPAKSVKILPQPTEPIPNANLRNPTPPPKSILNAIGSPPSFLNGLPRIQNISSSSYDGDSSNGSKSFSKSPINVGSLAKKVTTPLTTPRATPTHTPTGSISKGSTPEAPRRRGDKIRRLSAMFNNGSLTNDVKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6D4</accession>
    <name>K1V6D4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6D4"/>
    <dbReference type="STRING" id="1220162.K1V6D4"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008112_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6D4"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="78"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="650"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="109064" checksum="A3A8A85B6E0DDD77" modified="2012-11-28" version="1">MFSSPARPTPRRGLRMRESLSRSAFDNASVQTRSRLGSVRQLSPASSGGESTRTVRHQDNDEVYWSRDERHSVISNGPLPSEVSNLVNDPDFDFIVEGATGQIDSGSGFALVSTPTRCFAWNYAKKTHSSPTVYTFPTPIPSRSHLPNIPPALAAFYGARAAEPGLVLVSATGEVRLWESMSLALANVQRFQSIELPLGSDDFADHIYRLDDANFVVTTTSSAAFRLSVVNHGGRLVPTAQPFTRPGGLFNRASPIIFDSSERTGIVAVTPVPGGVCLLGKSTLQAWEIGPDGYAKFATLVSYSRNSGSSDHSRSHNSHSIVLFDFNASTNTVTIDKIVQISYLAMAFVHFADAIVMASLSNVPYEDTVRLKDSRNLFLGAGNGRSGASLVAMARLGGIMTIDVYAGSAQAPRLLIPQDSRRRLESHAEKIKAAIDLWDYQNRLMDLLADSIQILMNQLGVGAGDEDVVRLFFRTQVLRLDRLLEIVFQTFQAAIQAAGQNTDLSDWILEANRIFIVRDADTTVYQVDRERPSVELWTASDAIIDDLDALYSATQRLIKDRTRQMGSVVDEPAPQNASTQLARQQRDQATLKMQMAQLAAALCENMEDKLRTNATASPSPSVGTTSSLESFAHLAYALAEHHRDFPTLVYLTHNPASSEGPARIEMYIEKYGQDFAFVLYQWYIDQGKLYDLLSQDEVYGRLLSAFFAAHPHPELSWIHSIAIKDYGGAATALQAVEEDTTSLAQKHLQASLGKLAAVADAKARGQTLQIEELDDSLDLINTENALREHINETAPGSGHPKKANAKKYVAGLKLSYPAFEQVLERQVGALLDGDALDVEGLVDVLTLTMGRDEDAAIALERLAHAPLPEGRKQVALISTWRRVYTHDDEEAQRNLQRQTATYRTLRALKELPDQLPSSFTSLSPKVAAQPPLMEEIKARFPELPNSAHEALMADHEAEIEALQKGVSDGLAEGVKAITELVDSDMQQDAEGDVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8D4</accession>
    <name>K1V8D4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8D4"/>
    <dbReference type="STRING" id="1220162.K1V8D4"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_644079_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8D4"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="373" mass="40705" checksum="B20F6C72B9180622" modified="2012-11-28" version="1">MTKKKGGKKGKRLSMFSALPPTLKRALRSQPRLESGVATTAVHRQEEQPTARLLPTQPPSEVDDPEAEAAGADTERESSDMDMDMDSDDGVAPGDLDSDSDGDDSDKENVRPASARPVESSSPSSNTGSAVISRRVETAPQEANADHPWDCTGLVLRYTDAGALPKELRKYETGWFSVTPAEIAAHIAERCRADVVLDAFCGLGGNAIAFARTCERVIAMDNDPTRLRLARHNALYHGVADRIEFVLCDFVQWARTHAESGHADREPVDVVFLSPPWDYLASGTYPLSAIEPIPGDELFDLCAPISPNIAYFLPRNVDVDEVAALAQKLDMPQDDAPDGERKRDREWVEIEEEWVGDKLKAVTAYYGALVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8W5</accession>
    <name>K1V8W5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8W5"/>
    <dbReference type="HOGENOM" id="CLU_1240908_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8W5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="223" mass="21120" checksum="EDA6F185EEBD8F3B" modified="2012-11-28" version="1">MANTVSCRTVEPLLSICCQQLSGTVQGDQCVLSLANSPEIGGRFQGCAQGESSTCSDGSAHDAVSGGLGVTTPVTGTTNATSAVGGEDPSASSATETESASASASSEVGSASDGSSSDSASPTGTAFSQSSDAGTTSDSDTAAAVPAGGSTSKGPQTLKSSAATGPSPSKTAGATSSSDKASASRSGASAGSALPSPSSSARVERRLSVLALLGAVALAMLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAN6</accession>
    <name>K1VAN6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAN6"/>
    <dbReference type="STRING" id="1220162.K1VAN6"/>
    <dbReference type="eggNOG" id="ENOG502RBAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314782_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAN6"/>
    <dbReference type="OMA" id="TSNDAWD"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="929" mass="97631" checksum="1EDEC4A393C959FF" modified="2012-11-28" version="1">MALNAAVTLQPWEEQQLPSPTDEKKSLPSLDLSRTRSTSLSTHSGDTSLHRVVSGDPDCPPPAWKRRPSQRSSSIGSTSTSSSLPTRSQSLSASSPHQPQRRLPNGLRMTHANGLSPSASRGGFPRQGPPPAAFRGRARLGNGSNRSSLASYDGMNSEELWTLEDDPTPDMSNPTRSAAERPLDTVRRMSYTISDQSLYAGMPTEIIWPTAPAEEEYLYEPPPKTRSLTNVASIKRRTTLRKSKSKGAAMDSHPPISGGGYPKRAASKDALSSAHSSTTSLSIPHNKSQASLKSSRPPSMAGVGAYHYDLLGALAPRDGGYAIAAQIGHSFSPVSSVNSLDDRRSIHASPPGSFRGARVPSSRSSGMRWSVDGEDPILPPGPVRGSGGSMLSVSSTQSDDYDSPQSAQLAVAQATRPCEPSPLSMQTTTAADMDAVSSPVAVEAPQMFASVPAPAPINMFADVPVEEAEPAAADLKKSKTKKEMKAEKKEAEKQAKLAAKAEAQRAAQQKADAAKKAADDKRRAQEEAVRAKAQAKADAARKQQEDKERAKLQKKEAEQKKFEQAKAAEQRKIAEQKRAAEWKKEQKLKKAAAPEPKVVAAPVKTEQAPKRRTSLKFKRSSSGAGPASAAAVPVATPATRGSPPPAPSQASRLTPPVAAAAGGAAAVAASQLSSPSNSELYTGPRPPSDRTPSLSSTQASSTPRPEKRGFMSSLKKRFSMANMEPTPTLQKPRPNSIAVSQGSPTPSAPIAQAAPLRADAPAPAPAPAPATQRAPIVQPPPRSTSSPQKAPVQQQRPSMPPPVIIPPRGSSANAAMPVAIPMRGSSLAIVGGSESSDDNVESGASNPSSVIVTPTISMDRNSTSSLLEHPRPNGAFRERSDSGISAGGSQTTDGGLHTPPSEASFPAPLQNRKESDSMHMQPPPALTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAS0</accession>
    <name>K1VAS0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_07707</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAS0"/>
    <dbReference type="FunCoup" id="K1VAS0">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAS0"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_6_2_1"/>
    <dbReference type="InParanoid" id="K1VAS0"/>
    <dbReference type="OMA" id="WMTLYQR"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="75"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="297"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="527" mass="57579" checksum="34BC223FEB64F736" modified="2012-11-28" version="1">MIGGLLNKPDATQAPAPTPAPAAVPTTLDTTAATTPGPTAGPSTPTSATAAATSAPAPKPDGKKSPYFGAGAGLMILGAGLAALRRGAKTAAHLGQRRMLITLEIPNRDVSYNYFLEWMAHQIALSRSLPESERGMKGVLSGKQNFLPTHELAVQTQTQALANGHIQTDFNLVPGPGTHWFRYRGEWFQVKRMREQKAMDLATGTPWETITLTGLSSSRELFPALLNEARELAEQHKEGKLITYTAMGFEWKQFGKPKPRRPLSSVVLQEGKAEKIADDLKAFLARNKWYAERGIPYRRGYLLHGPPGSGKTSFIQALAGAVHYNICTLNIAERGMQDDKLNMLLSTVPERSFILLEDIDAAFAKRVVQGADGYQSGVTFSGILNALDGVTSSEQRIIFMTTNHPEKLDPALIRPGRIDVNELIDDADGEQAYRLFIKFYGRNINEIIDEEKGSGGLMNEEELSQEEVERLGRQVQDMVESAREQGRRVSMASLQGHFIRHGAVDSLEGIPDLCVSRPPYGVESESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAT5</accession>
    <name>K1VAT5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAT5"/>
    <dbReference type="HOGENOM" id="CLU_448480_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAT5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="616" mass="67445" checksum="EB7888F38BF10BE9" modified="2012-11-28" version="1">MPKAKKSKGKGKERAVSLDVDSPRFRAKPYRWDKLGEPISNADGWAKTNKRDKQKSDLMLKCTRSLNPTPLVVELTKQGYCNVDRKLAKRSGLPTPPNHTPSGSQASMSVFSATPPSQAGTHALTPDATPGATPTPTPLPRVILRAPGYTPVRPLEHVSHSEETDDDAMEVEASVAPRTPVLPRGTAEPSRHLPPLQSLNRGVSPDRRVTSLPAISQPVTPENRSFRSRPLPSGSPTPERRQEFMTSPHSSRTPTPETPSPPRPQKPAISVVTVFSSPPGATRFAHFPDEDSILLRPGDGRVPFLIPYAPNEDDARLVNQLGLSPTYMWRSSEPCVACSHEDVPSVFGNIYVPKQGWGIVGAPPCLRCAAVGRTCTWRIHSSDGFFATSRLNFVVLDSPGVTGTGVFVKASDIEAHSHGEIAEALHRGEGEYDLGAPDADAKAPHFCTANILAEDRRPRPPLAEVVEALRGREIYTPDLVSDILRRLPYTENGMEAGLLRAGDEWGAWSFTHGELCLYLRDTPSHRQWDSRELEKVESVDMAPAMVHAVECALIGTELPKSWEWDHTKLIRERHRSLLADDAERGAALYELFRADLGACEMAVQFAAQSPGIIQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBK6</accession>
    <name>K1VBK6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBK6"/>
    <dbReference type="HOGENOM" id="CLU_518942_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBK6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="525" mass="56598" checksum="D50BA9B82D96BB08" modified="2012-11-28" version="1">MGPIVNNSASQMRSPTRTTDDIGSATLSAASRALAIDHITDLVCAALDTPSLLSALRVNYAFFQSAGKALYRHLYLGCGAPLSGALVGNDTARRAMLNAYHPCEGQTWDEAFCLWKLSTISTAPERPVKGKGKPGKKAGVAAASPAVAEMKAALIAARLPPLPDKEIKSFIAHLVDRTIGALHSGPGRKRKTRNFKLQLLRYVRVLTVTSHHRCVCALWGAHVASFFPNVEVLRVVPNVSADGALIPACDGADVKPCPFLQVNAQKLVLRNLDRRGPPIPGHLSWSSPNLERVSLYLPLDGAECSLIPPPSLKGQFPGVKEINVVFHVWHGARVVDVLFPTKNPHLPDALLELLHSLTIPGRSANTKIKIHGIDTIALDLLGSFVVRADALMDTTAIDPAFSMPSAAEAQTLVSSLIGYVPLSYLSPEDEAFAKFVMDALRCDAATGFIRQLWHPGKGSPNAAEIKAAMRPNSNVSFGTLEEYFESKECEEDEQLKSRGIAYIATRSAEYVQGSAVCPKWKRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBY6</accession>
    <name>K1VBY6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G protein beta subunit-like protein Rkp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBY6"/>
    <dbReference type="FunCoup" id="K1VBY6">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBY6"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="InParanoid" id="K1VBY6"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="314" mass="34510" checksum="71F49C1A1FE14288" modified="2012-11-28" version="1">MGEPLVFKGSLAGHAGWVTAIATSSENPDMILTASRDKTIIVWQLTRDESSFGFPKKILHGHNHFVSDVVISSDGQFALSSSWDKTLRLWDLNTGLTTRKFVGHTGDVLSVSFSADNRQIVSASRDRTIKLWNTLGECKFNIVDDGHSEWVSCVRFSPNPVIPVIVSAGWDKVVKVWELSKCKLKTNHYGHTGYINTLAVSPDGSLAASGGKDGIVMLWDLNEGKHLYSLEAGDIVNSLVFSPNRYWLCAATASSIKIFDLESKSIVDDLKPDFNELSEKARKPECASLAWSADGQTLFGGYTDNLIRVWAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCQ2</accession>
    <name>K1VCQ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCQ2"/>
    <dbReference type="STRING" id="1220162.K1VCQ2"/>
    <dbReference type="eggNOG" id="ENOG502S1ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_271923_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCQ2"/>
    <dbReference type="OMA" id="HVERTHY"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1190" mass="127469" checksum="7D885219F252BC1D" modified="2012-11-28" version="1">MKKLFNRSTKSSEQERDGSMTPMSTSHQRSSGIMQGHDLHKRRHQSATVTPFPLDAGRANGGSRPPSHPNSTPAGPMQVQPQIVPQPMNAAMMQKPVPPPPGGAALASATPPPRPPRDSARGAPVAPGQPDYRQMEEEAASAPFRRDGGNDRTSMANPRSRSGTGGTGSSYVMPTPEPRSPGMPGPGRSPNDPPIAQMYARPDTAMSQTAPTQPAQPAFFLPPGAGPPSPQFRPATRPSTPPTSGRFSHSHQGSIPSLHNVASNLPPHITASSYEGPDGYSSARSRGYSASSQSGRGSDQEGSVHPSPQVVNMLGGKGGQGQSPLNRSPLANNFNSTSADDGDEEAHRPRSRRELNASGIRSSMPSIMGGGGHHHNVPESNRMENLDVRHDGKHDSRHFFSASSSHKDKDDKDKEKKKGFWSGWSDRKHNKLSKHQSNPVQPRPEDEAASSLGHGQPDPIDTHSSHGHGQYVVSSNGTTPTVTTAPVHLDKDLPVVMPGSVEDRPSAEGYRGDAELSTAGGHASSLGHGGMEVAPKPSSRSRSASNAVSTEVLTSARETGTDRQLCSRRETTQNAVLELCEKINLSENPDAASKDAARGLHFATCRKFMAAVEPIVTNKLDPPPSQATLRWAIDVLAGLTYAYHAERGCEGLQELWKKIKLPEDLDIGRPLPDDFLLYSPGSLPPNPSDAASINTTTATVRTDRTPKDKRDKVRRKRDKDGKEAKDSVKDRGKPRDRPKYHVTPSHEDDIQKLIVEASEGKENARILSEALVYTAPSEFDDKVILQEYHSRCQQSFTSLSTQMDWAQSEAAKSRRVADSIELQEATNMATPEESALDVLLEAHGKLSDAMEQYDELARSAAYEKEVRAVEEISKKDTRMDRRQKDMLMVDETMRAEGSAASRSPSPGQYMDADARQSHDQHHSHEQMRASFEKMRMPQDRPAALSPPPIAMPVAPSAPMSPVYTGAATPASAQSLGTTPGIASGLAAGAAVGAATGAGISVMMNGFQADRSSTPSPEDHPLPQPPLRPAMTGQRAPSPVGNKQPAARRMGGPRPLPLPNAFRSHNSTASLHAASDMHASSTEGPNGTANGTPAPESSAEEIDDDAPPKMPSRKALGKRRADPDNDFDPDSLFTGRTKPPADNASEISVSLDDVYAAKPIKYAYDAYAERLALERDEQAKAAAVAAPVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCX5</accession>
    <name>K1VCX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall chitin catabolism-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCX5"/>
    <dbReference type="STRING" id="1220162.K1VCX5"/>
    <dbReference type="eggNOG" id="ENOG502QRF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564039_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCX5"/>
    <dbReference type="OMA" id="CETEGTI"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="179"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="484" mass="51671" checksum="2EFDF3DC2F61CE63" modified="2012-11-28" version="1">MSQAEARQRGSPKAVKSEKSRCGNGWSFQSHRSPQAILLGPNAHLLEFPSLLLPTPSPTDPPLGPGSILTITVSRDMEAERASRNAFETLQESILEEYGTTSPSKPVLRVQNVTQTSVALEWDPLKLGSASFRGLEMYRNGQRWGRVGGDVGTKEEKLEWKTGGLQSGEEYTFQLVFNLTGLYVTFGSIQPPTLINQLRGCLEQIHAREAPAVQLATTHFVCSSPLTGGDESGRGGHLDDAYTQAMAANLPVVSPAWLLAVAAERRLVPIANYLLPAPTQSIDTAGGPAPFRRPSSSRPSSLPTPGDLGTSNHDTIRSPSPETVARMSNTGPAMSPSSRTQSFEHRQMSLPTEPESSGSGRPRSPIKPESDGRLDRGFKFPLSVNTEDKTEQTLSSPLKQTPVVHIQAPSTDGPVSAPVGCDDKPTERSQDTPDADREEVSAAVSASGGQESSVDDGAKDSQVDDSSKPSKAAGDANLDEIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDU7</accession>
    <name>K1VDU7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome oxidase subunit I profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="10"/>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial DNA endonuclease involved in intron homing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the LAGLIDADG endonuclease family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDU7"/>
    <dbReference type="STRING" id="1220162.K1VDU7"/>
    <dbReference type="eggNOG" id="KOG4769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559205_0_0_1"/>
    <dbReference type="OrthoDB" id="2443709at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006314">
        <property type="term" value="P:intron homing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0404">Intron homing</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="488" mass="55581" checksum="9FFFD694F2AB877D" modified="2012-11-28" version="1">MTRWLLSTNAKDIGTLYLIYAIFMALVGTGLSVLIRLELSAPGSQFLAGNHQLFNVIITAHGLIMLLFAVVPRMAGFGNYMVPVLIGAPDMRFPRLNNISFWILIPATVLLVGSVFVEQGAGTGWTLNGNMVSEMLNLSRFNTTKIPLDAGNSSTWSYLLVIFSLIAVKMVVTRGQSAWAKYLHTSSSSETKCGTLFKDKSWFEQWLVGIVDGDGSFTFTGTNGKWTLEFKVGQSSYNLRLLHYIKSMLGVGTVYVPKNGRTARYRLRNVEHIILHLIPIFDKYPLLTSKYYNYDLFKQAALILYDKNLTSKEKDVKLQNLKRNKNIPNNYISPRWSIINNIVSSKDRASLVMSKPWLIGFTEAEGSFFIGKKGGNRYVHYFVITQKLDLIVLQAISYILNIPLNQHKTYFAVETSKSSNIANIIDYYNNTIKGMKSLEFRIWSRSFKKGEKYSAPERYEYLRKIQEQMRNIRSIRLDKNFQKANSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEA4</accession>
    <name>K1VEA4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEA4"/>
    <dbReference type="STRING" id="1220162.K1VEA4"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="InParanoid" id="K1VEA4"/>
    <dbReference type="OMA" id="WIIALER"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000363">
        <property type="entry name" value="D-isomer specific 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="139"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="372" mass="40358" checksum="9BA9BDCFABA1D2B8" modified="2012-11-28" version="1">MSRALDTIAVLMPLPAKALEKVRSAFKTVHYAPSGPDVPAKRLPAEVWKDVEVLFCDWTGPPKDLELSEVPNLRHVQLPTAGVDGALANSKLVQELAARDPSASSEGPTVSSASGIHVFTIPNWVVGMTIALSQQHHVMARFARDSSRANEQEQQHWADEMEVGPVGKFYNRPLWGRTAGMLGYGALGRETARLLKAHGMRIIAANSTGKASKFEDWTPEGTGDLDGSIPDKYYSVKDEAQFEQFLRDTDVLVCSLPGTPATRHLLDAKKLALLKPEALFLNVGRGTLISSEELLKALESEGLFGAAIDVADPEPLPDGHPLFTHPKCIVTPHLSGHAKGEEVLGAELAIVNAERIRRGETPYNVADLKKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEB2</accession>
    <name>K1VEB2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEB2"/>
    <dbReference type="HOGENOM" id="CLU_973827_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEB2"/>
    <dbReference type="OMA" id="NGWRESA"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="35726" checksum="18538DF73307F68D" modified="2012-11-28" version="1">MTEPLVATGNGTCDVLMLNSGDLPQTIKADWIGTHEDDPVVLPILVFVIKHEGKYYLWDLGTRVDFASSFDPAILARFQRSPPVVHRKLPQDLPKDCQPLSGVFISHFHWDHCGNPASVAPGVPVWVGRGTLEGLEKGGFGAHVGPAPPEVKARIKEIPEGDTSVWGYEQKGWDVFGDGSFIMLPAPGHCAGHCIAIVRVQKNPDAYIVLGSDSGHSRALYEPCPCHHATADFGRLPLHSDEEEAKRNLARLSKIHARDDSWIIVAHEREAKEVVPEETWLGDWREKGWKDKVGQLRKDEALIDCWADKMKPQKVVGEESYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VET0</accession>
    <name>K1VET0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VET0"/>
    <dbReference type="HOGENOM" id="CLU_1082546_0_0_1"/>
    <dbReference type="InParanoid" id="K1VET0"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="257" mass="29003" checksum="AFC9D82F42FF7482" modified="2012-11-28" version="1">MTVIDHNVFPHIMEAIYSYADFDTLLAMRPTSKTYRDWSDARLSEHVVVHVRRPKNEQGKPIWAAGSRSVEIHAPGGRRLPFLRSWKRANGDDLSQWRAFGKYFGRTTTLDLADEGLMRGRTECIKAVCPKLHTLRMLNNYESEREVANMSSSAVSFPGNAKDGTEGYRVRADEEWAQRVRFRYCDLHDPGDPSKIKYAHAYNNNIQTLVGTLSLGLWVRSMRVHSAWWAGGIIQGGDTGIRCGPMSSPVETASLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF26</accession>
    <name>K1VF26_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF26"/>
    <dbReference type="FunCoup" id="K1VF26">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VF26"/>
    <dbReference type="eggNOG" id="KOG1967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005943_1_0_1"/>
    <dbReference type="InParanoid" id="K1VF26"/>
    <dbReference type="OMA" id="FSFMPEF"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="467"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="938" mass="102287" checksum="AE7A38581AC6FC5B" modified="2012-11-28" version="1">MDIERDIRTQVSSSDLNPSSSLIQRLTFLSNTIAAVNKSKINGPATLTALTELSKLPTFDDGAAVDVYKRRTHKPSGIRSFKAISEEFINSYSKVVDGEKDPRNLMLLFQLDKVILSEFNVKDQIEVSFKVLRELTIQEMFDITFCYFPITFRPPPNDPYGITSDDLKTALRACLSASPYFAKQALPLFLEKYPTSAGQTMTMAACFPVYGAEAVGERGEELFDCLKTEILYSSDQGIENSALTALESLARTLYPTQSDAPKGLGELIVKQSLEGLSDPMKNSAPGCAKCLASMIRASPYALAQALPQLFRDFNEPKLPSYRVPLINVITTLLLAARSVYGAEGATRRQSDEHSLDRYRDSLLDVMREGLRTDQLKTAAIRGSVAMAEIPDFLDALQVEELVKGIDNLLVHDNDEEVRTAALSGLKSIAASNPTIVQNSTLPLLFHALPDSAPAADDSAAREAYRRVLKALTELCAAPALFQTLVVRITTKLDLLSTAAGDAECTAAYAWDLLHAVRVVLDAKLGDNHVDVPKYYAEIVPRFTQLAVVAAQSADRPLFRDVRLLRSTADITELLFWEQSAEAIFERAYAGFENGQLKQVVYDEKAIQDAPPLKGSEAERNLVALYTALVRGLKPETVLPFSDADAFLASKVEWALTAQNAFQKRAALDLISAFVNKHAASLSSLPSLLETIWATVTDASQPAAKRQAALQVYFHALALLRNELAYTASERALSLLGGEDALAHATASAFGILAESPGKKPRSHLTVKKLWSFLLPKLLAGEEGASGAAREPYLLAFAALLPLVPASLYLSDLRKLLPILLRALAIESAEERKNVITALTSVLETASSRTETDQLLHEHAEEIVDGLLRAGRTSKTGKVRAAALAGLGVVPDAIRYETLGKAKARVIRELGLCLDDPLRGVRREAVDTRAAWYTYGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG35</accession>
    <name>K1VG35_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG35"/>
    <dbReference type="HOGENOM" id="CLU_090088_1_0_1"/>
    <dbReference type="InParanoid" id="K1VG35"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="245" mass="27139" checksum="E148C18C2BE7DAB5" modified="2012-11-28" version="1">MTEPHSGPKEVIDSAKWTEGDFSLVSADGVRFRVPSRALFVARYVARHSTLTGSEVLATAGQSVGWDLLEWDFADPQLESAAVLDRFLELVVNGNLIRLSNHDPVDMGPCDRYLHLLGFLNKYKCTLALRLFELCAHEYLVQGGMPSRTVFVLGAALDNPGLCAAALQRFCTDDNEKRLHSKVHELCGADPGMVSDELWEHLPARYARAWVVAWAEGKGVEDHNTDRAHTLGGVVLHFVDRLSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG81</accession>
    <name>K1VG81_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG81"/>
    <dbReference type="HOGENOM" id="CLU_2005504_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG81"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853760" evidence="2">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="124" mass="11021" checksum="AE41756D7865D366" modified="2012-11-28" version="1">MKFTAAALLLAGVSSAALSECISNCAKETGLCASGDYGTTGESHSTKPADGAASSGSPTASSGNAANSAGNAPSSAGASRSGGAASSVSSAVAAGASAAAGNSGAGALAAPVAGVLGAVALALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH48</accession>
    <name>K1VH48_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase I subunit RPA49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH48"/>
    <dbReference type="FunCoup" id="K1VH48">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH48"/>
    <dbReference type="eggNOG" id="KOG4183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034953_2_1_1"/>
    <dbReference type="InParanoid" id="K1VH48"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37721" checksum="0DB0A53A2FC91598" modified="2012-11-28" version="1">MASQDSKKSKKRKSVGGSSSDVTISMEDSMGVGPAFDDPSSSAVTKQHTLIAGETEDVEYFSTNRDRYQAGEGHDCQYVPAVYDPSTKTLHVHPTTPLYLLAHRVKRMREAPLSETQRSELWKQRRNDLGETFGTRKAKSQIKAEERNKVDANAMQGVKARLMESIGVLESKDDGARQAAASSSAKKHNLKMLYYLACLLSFYKFAGGLHKLNATELPAKFPGVPAQILNGMLTTFAEQDGKKFKVTEKSGTKLFAWICVCFLALNGWTIEVERVARELAKETPKVVDMFKSLGCNVDLPTPAEREKMGIKLADANKFRKATLKAPLKFPKTKRRGPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH59</accession>
    <name>K1VH59_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_05567</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000347">
        <property type="protein sequence ID" value="EKD00131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH59"/>
    <dbReference type="FunCoup" id="K1VH59">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH59"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_6_2_1"/>
    <dbReference type="InParanoid" id="K1VH59"/>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="513"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="684"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1097"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1097"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1132"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD00131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130522" checksum="D07C1BDF347DE49A" modified="2012-11-28" version="1">MGTFGKFPVDAVLSLHQRILAHDALASASSGGSMSGMDHEDSDVLAAEPRRKGGLRPSGAAPKFKTPAPRASLLGLDKLAAEKRAQASEPPSKRFKVEEPEEGAIPAVPVKREHTRVKAEETPSHGGGLSEIARQRLEARRREKNKPQTQTSAAVPKREERRGFGDFQEKLNKGSWQDRDRDRGYDRRDRDRGYDRDREDRRDDRGYERRSGKNWSDEPTPREDRRYDGGSMRVPNRGWDETPSGRRGDGGPGPSGRSRGWDETPSRSRDDSPVFEVDAKEWEEEQMRLDRDWYSYDDEGAVAGDEEHNPFAQWSNLETSKEAEMEQKVAKRQTARQAQYWENNRMLTSGVMKAGDLDEDFEDDPESKVHVLVHDLKPPFLDGRTAYTKQLEPVTPVKDVTSDMAQFSRKGSALVRERRDRKERERAAAKAASMAGTTLGNLMGVKDEPDLGEEGKEVDENNYKAGSQFATHLQKNDGVSDFARTRTLKQQREYLPAFAVREELMRTIRDNQETGSGKTTQLGQFLYEDGYCANGIIGCTQPRRVAAMSVAKRVSEEVGCELGGTVGYSIRFEDCSTKETKIKFMTDGILLRESLNDADLDKYSVLILDEAHERSLSTDILMGLLRKILMRRRDLKLIVTSATMNADKFSKFFGNAAQFTIPGRTFPVEIYHSKSPCEDYVDAAIKQVLQIHLTHPKGDILVFMTGQEDIETTCAVVEERLETLDDPPPLAVLPIYSQMPADLQAKIFEPTPDGRRKVIVATNIAETSLTVDGILYVVDGGFSKVKIYNPKVGMDALQITPISQANAGQRAGRAGRTGPGYCYRMYTEIAYLNELLPNNIPEIQRTNLANTVLQLKTLGVKNLLEFDFMDPPPQENILNSMFQLWVLGALDNVGDLTDEGRIMSDFPMEPSLAKMLIVATKHNCSAEMLTIVSMLSVPSVFYRPPQRAEESDAAREKFFVPESDHLTLLHVYTQWKNNGFKDQWCMKHFLHPKILRKAREVRGQLEDIMKAQKLPIVSCGTDWDIVRTWATLYGLGYMPDYVVYHELVLTSKQYMMCVTSVDPYWLAELGGVFFSIRERNFDGLARARAQKEFSRKTEMEAEMARQRDERERAQADKIAKAARTPRIGGVGTPARAGATPRRAGIGAGSRTSATPRRRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHT2</accession>
    <name>K1VHT2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHT2"/>
    <dbReference type="HOGENOM" id="CLU_1332762_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHT2"/>
    <dbReference type="OrthoDB" id="10426290at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="22718" checksum="63B40DCCA86079DD" modified="2012-11-28" version="1">MPTDKHISQLLQRALKGAKRPYLLADHLALTRMGPASISAIRDSGATYVDNPATHWVLQSFQKLSPEGSGGKERAQAASKVLDELVQLNKGADDRLRKVQDAIQERIEKRREGQTDPAANEWFDKFRDQWKKAQPMSISGELDFDGYPDSPASPSPQRYLNSFLSLIDALGEGEIVLVSGSPTIVNNVNKFTEDDGNVQTIVVGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHU2</accession>
    <name>K1VHU2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHU2"/>
    <dbReference type="FunCoup" id="K1VHU2">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHU2"/>
    <dbReference type="eggNOG" id="KOG0284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_77_4_1"/>
    <dbReference type="InParanoid" id="K1VHU2"/>
    <dbReference type="OMA" id="REERCIT"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000069">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="380"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="658"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="722" mass="77277" checksum="C9EC00C78FEE639B" modified="2012-11-28" version="1">MEDLLPFEPRDHMGHELGFDVVGRSQRQYPLDPLSRPRFSPHSPPTMVAASANPEEAGPSRTRAPDSWRPEKYLEPNHPDNEEVLEQAAYQAAVTRPPGDARANRKYKPRRTVDYMGGVQKWRMLGKIKGMRDYMPPIHPNPSDIINLLPPAAHIRDTSTSICDYFVHTSINKERSPTRVVKWTPDARRLLTGNDKGQFTLWNGASFNYESITQVHDDSIRAMSYSHNGQALVSTDKSGWIKYFTPHLTNIHGFQGHREACHGVAWSPNNEWFVTGGDDGLVKIWNYRAAETERELSGHGWDVRCVDWHPTKGLVVSGSKDMLVKFWDPRTGKDLSTLHSHKAVINACTWNPDGNIVATAGGDNVIRLFDIRTFRELESMKGHTKEVNCLEWHPIHHSLLCSGDAAGSIAYWSLQAPDPSKPVTMMENAHDDAVFSVSFHPLGHILCSGSKDFTARFWCRARPAGGHETDKYHLGEEGAMRAEQAQATSKWPGLPPPGESLPGLPGLGLGELPGLGRAPTSSEPGRRQWGPNAAGGGGGGAGPDRGNFGRDRDDGYGQRGGRNNFGRGNDGGRDFGRGGDQGGRDFGRNRDRDADPYGGRSRRDLDRQGGGGGGGGGFGGPGTGANAGAGGGPGGYGAYPPAPAGYGNGPNAQNGYGRQQGGYGAGPGGGQGPPGGYGQQGGQGGYQQGGQGGYGQGGQGGYQQGGGGGYGQGGGSRYGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI63</accession>
    <name>K1VI63_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_01833</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI63"/>
    <dbReference type="STRING" id="1220162.K1VI63"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001871_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI63"/>
    <dbReference type="OMA" id="SWKVHKG"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="802"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="485"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD03820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1127" mass="123280" checksum="8B77AC534EAC5FA2" modified="2012-11-28" version="1">MMTSSTLQRPVAPAPGSSNSDRQSQDGPGETSTQPPNGDEGGSGGGAVTTTANMTAEMAGQVVLHASSAAVALAPTIFPTPIANLVTAIATSARLSLRVTAFFIEAILETSQNNPEKLDVQADAFLNVLDRWTNVGIYVIHHTFTLAELFAMSGFYLTANTVQSASFAAHESVTLFDSLFGSNESSRALSSIIALVRQELLEDERFQAADRGKVASLTALTKALTAFACLQNATWSRSAKRLKMRVDDETFKSEVSEPTHSALPEAGPGPRTIAARREREREIPSLLYETDEQGDVTMEDVSSRPSRRSSLRSRQQEDDELFRQLEEFVGDADRSVSAPVSPIAKTRDRSNSQPHRTLKRVRGDVFEIMDELQESTVVTRTLERVDTRPSLKRAQSETAADILVEEVEDEAMSRPPPATPLTTPTGVMDEDPAEWIEVDQLLDGQDDALVPSAPNGRVAAVASEPPNAERIQLVLRTMTNKLLQRKRTVRRVQNVGLSPRMSPSPSPPPSHRKEKERERESSPATIREHERPDVRQIDWRQAVAASRARTSGTPPPRSGTPPRSSSHNDIGPSSRRSSSDSIAAGNRSSLKPKRRFFSGYSTRGHDEPRRNNSEGGLANAFRSTLRRKPTAFPGVEDEEPPSAPPPRANTPRASQPRSAPAPAPSPLTPMRGEREHSVHQSVRTRSNAIHTSSSQIFGPDIESSASLFPHEGLIRNIHRFMRYSSAAYGQNFLRILGLGNTDFHYTTAGGHHANSWAFARHTNIPINNLILSSYTETSPLSGHKAPPLVHYIAVEHGLRAIVLTCRGTLGLNDVLVDLTCQYRPIQIEGVEGDFQVHAGMHESALQLTSRASTVHQCLVEALEQYPYYGLVLCGHSLGGGVAALLGIEWAQRATLFMSQNAKRERKVKHPPISTKFVTSFGSGLPPGRPIHVYAYGVPAVASYDLGKYCDGLVTSVIQNSDVVPSLSLGVLRDLKNVAVTLYEEGGIAEEIVGRILGLNKRKFAFEGDSASSDTPSSGHNAADDEQMLHDWMESLIKTMRADMDNDKLYPPGSVYIMEYSDVFLTASSGAGENNSNSSQRARRVILRLCESVRERFGELSFTKSMLKDHMPLHYERATELLIQGVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI64</accession>
    <name>K1VI64_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI64"/>
    <dbReference type="eggNOG" id="ENOG502SCTC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514070_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI64"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="530" mass="56634" checksum="351CABAF728A34C4" modified="2012-11-28" version="1">MLAGRNQSHASRHRQHDCLHHQQQHTTRTQQKEDVQAELLLSTLFLCFSGLDAACRPQRRQDASSMAATLGVTSDERLDPSPAPSSKEATAPAASSPVKVHTSPLRPLKSVPPFSSHSNFPAPPPPATPKRNPFARTTSDACASFKRSSLLPPTAHSPIRSPRPADTLSPRTPAAKRGWRLLWRGGLELTTGITFLARVNPGNGVSPFPNAGAASAAAFAAANNSPNLPSDADLSLSLESLRGRKFLQVRGLTLLEDEELDSGDSVQVSITSPLLAAYVESHFSRSPLVGGRTVLGLVVGLGDAGVAPRYFPANPPKKPPPPFPNRRSLSRAASVASLGAAPPQSAPPSVSPVLPAFPVPNGRSPGRRGEKRPRRPEDDDRRRRKAGKIVPEPSSGVAEDPEAIFGRAPSVAPSQTGDKPLSQRAADNKNVSLVSVLELTADDPQACDAGDGVARLLALARRLQGGLRHGHARSVFRFEINGRLDKYRVSGIIHQHLDMYLASASESEDEQPLRSEPTLVDIRSEPEYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIG1</accession>
    <name>K1VIG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIG1"/>
    <dbReference type="STRING" id="1220162.K1VIG1"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_317880_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIG1"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="916" mass="103300" checksum="717DFA73BAE10587" modified="2012-11-28" version="1">MADPTAFYEPEEDELLSSLAVPQYGTEGYDEESYRRLQELEQHAYAQQMAAAEQEQAAALEQVPEDVKRFIVLFHQAILENDLPTITNMYESGWNKLTQSEWPEAELIAPLVQNDQVFLTLYRELYFRHVYARLQPTIDDRFQSYENICELFNYLLNSDGPVPLDLPIQWLWDMLDEFVYQFQSFAQWRASPKNKTEEELDMLAEASQIWSCYSVLNVLYSLMQKSQINEQLRAEKAGKSSEEVAEIAGEYGSKPLYRNLGYFSLICLLRVHVLLGDPTLALQIMENVELTGDAFLTRITACHVTTYYHVGCAYMALGRWPDAIKTFISVLIFFIRMKQYHTRSYQYHTITKQCERMYALLAICTTLSPGPTDDSIMTIVKEHYGDQLATLQRGGDDALEVFKELFLQACPKYLSVNPPPYEDPDALQAWMANPPPDAVQRYLDLFLSDVVAVRGVSNVRNLLKLYTSIDAAKLAAFLSEGADADAEEDVLQQLMVLKAASRSYRYEKGEGSTSLLDGHRFVTNALDFTIDNTMVHVEETTTHRRFAGFFIRNAEHAQRAFNTIRAAPLPTQRKKQEKKEQQEGKPEQPQRKAAWVPKSRQVVVITGGNSGTGYATAKAFYEAGAKVYIGCRSEERANTAIENIQRGGLPNLWGKWVYKPTARPEAVGTLTYLPLDLSDFDSIDNFVAAFKQRESQLDILYANAGIMATDEGQYTKQGHSLQFGTNVLGHQRLIKQLIPTLQATARAKGTPSRLIVLSSQGHIAAPPGGVHWDSLHKGGKVLDKWADYGQSKWGDLALSRYVAKTYGPGTRGGQDGAIISTGIHPGLVATNLGTHLNGYKVMRYTPGFQHGMQVDTYTGALNQIWVGQLAEHDAQNVNGKYVSCYQVVAPQRPDLYEDVKVDRVWDWCNAQDRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK46</accession>
    <name>K1VK46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK46"/>
    <dbReference type="HOGENOM" id="CLU_506402_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK46"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="538" mass="57606" checksum="C24D2624CB5C18B9" modified="2012-11-28" version="1">MNSQSVGVTSPYAKGLWIAFLPLKMSDGNVGWILTTRFGQRLVRDDKVMAVNLRVWLQCWFAQNDVYLPAFIEHRDRLELRREEIIQATLGYLPDYLHPLDRNTQTEFVKSCHQVASRVMIAHIEGAPTPILNEEDVERLMLTVREDVGKLLGSYPLPALPRDLGVILEASESSTPTDAGSPATGPVEDTAVGTAGGVTPSVTATSVTPPTNPTGVNNSATIQPAQIFEIEDNHGDETDGVVSGPELKLPVIDIEAANGAGYFDPRATMDTPPLRNGSCTTVNDSELASPTIEESALNAEESAPVDDKGKGTTAQHGAQPAPSVADSVVVTQPAPAVATESTTSHQDTAPEEDPTTANPIPTSPKPPVTPTNTPAASPSTSGHFFQERVAVDTDNPATFAVNSNPATIPAAFAVMNTLSQAERAVRTHNSDGGSFRSSRSSKNKPFTTENPFAVPAKSTPSIPELRRSQSAPMSRAISLPHPLERAKSEHKPSVRFADEVPAPWSPKPRGYLMPMHPEPKPAPPPPEEPESEPEPKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKB5</accession>
    <name>K1VKB5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000220">
        <property type="protein sequence ID" value="EKD04605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKB5"/>
    <dbReference type="STRING" id="1220162.K1VKB5"/>
    <dbReference type="eggNOG" id="ENOG502SD3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102663_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKB5"/>
    <dbReference type="OMA" id="TRQARYI"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25229" checksum="2AAD1902393B0E6E" modified="2012-11-28" version="1">MLASTSRTALRRAGTSAFSVRIPRQALEVAPAFSADLRSLSGALADSGALGDRLSSSPVDPVVVTIDRVEVAPGRMRNVLAPTRQARYIPWKRASQRAKPFIAEPARPDPSDQDALEHPAVLAARARAAAAARATNVGETPTEMLSKLLTLPTQLTFARRTISPETPALHGSLTLNDVAEHIAKLQGLTGNDVEVNWVGHEVGERMKELGSWEASVAIKGYGGESVNVEVEVVRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKE8</accession>
    <name>K1VKE8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKE8"/>
    <dbReference type="HOGENOM" id="CLU_310172_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKE8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114723" checksum="B3143197B46C71CA" modified="2012-11-28" version="1">MAIHAAGNTYSPQQLTSRKCVPKQQAGRNRKDWEDVESFLRGQLPGFQWEQALPEPSIHRVVSGFSHRNTKFVDLIVPKLKTVEVQQRLKKLIKKVRRRRSKAPELVTNNDNVCTLSFAATTSTRDIARLVAVVILRYLYFCGRMWVVTMRDFGSAWLDPVAVYLHLVEAVLEQNYVRFFDDDGKTTLLGTVDLISGLPLTHGSLAGSSGKVTYLAHEQHGLRASLFRGDETDDDLYGNHGHEAFAVNVTRGSWRYPTLVAHIRSRQEPLQKLADSLAKVGILPKVTLPEFQPSKQMRELWMNNRVDPLEAVSRDPALPERLCRGLEAARREVKELADARRRQQAEAAEQANANGRRLMSGAQMPGGWIDMPNAHQVVSPSDPGCPVKLTWASASESLHRLLRLTSPLRAADSIDNANEGGQRETRTHLCAVPAFPKRASAEFQSRHTCCECGVKRSRVWCTGPVPGAMLCGQCWGRQFVCPFCSSEDSAWWYLIDGQDSSVRCCRTCHQNQAQGGSGYRLLEGLCLYPDCDTTYNVWRPWPGRKKAGRVCARHNASLRRDTNDCTRLTAVLDEILRSLPHRSATPLLLKREIAKLVDTRDITARARSGTRRYNKRPTNPKIDKTRRSAWPVPAASPDKRHQIDAEGPARHSTGNTDRTNCIHNSAKFAMLETSRDITDLAIFMTEMIPDVDVSGLAALRNKFSNRAINALGSPTARPPSSAPSTPSQASRTTTAAEQGVLAGPRPWRTGTTGIPQLDPAAAAARAAVPRAATPLAAHAEPALAGELGIPQLDPAAAAARAAVPRAAGHVAAPATLGAPARLASPAVLPVNFQEPGSHIDNPIVIDVADFGQFADVLAKVGVIEPVKLPEFEPFERIKALWKHNAVHPVEAVARDLGLPGRYEDGLKKARTEVMLQALNRGRKQAVADDVAVYLQLWEHRVISVVPRRRLQLGRAIVCELPPKEAKGGFRESYQEDPWLPRRPLASARIPSARRHTTSGTGSTGSAALCASVIGTTARSAVIKESDRVSPTLWTTFSPTLMGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKY6</accession>
    <name>K1VKY6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adipose-regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000356">
        <property type="protein sequence ID" value="EKC99916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKY6"/>
    <dbReference type="STRING" id="1220162.K1VKY6"/>
    <dbReference type="eggNOG" id="ENOG502REBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696742_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKY6"/>
    <dbReference type="OrthoDB" id="2593582at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43887" checksum="E42E5AF947BB7122" modified="2012-11-28" version="1">MSTSSQRRDVRRPTPRRRTLSTQSQPNSDFVDFLHRLLDILFTPRITYPLRLIRDVITSPLTISVVVKTALLALLLLASAVFSFLAVGAFWWSWGTGGSVETEGWLVYGSRTHRTPHAVLPINLDRFQEDLPYDVQVELELVRPHSDAPETGNFMVSVELRSVRNPEHIVIAAAQPIKERRRKGSLIPPARGNEVVLMTKELLEGVVVRPGRGDGGVGAVFVSIGREDTHDNAGYHREVRTTGWVVVRFVPHPTGVRWLLTSNPLPPLLILPPLSLVLTISSALLGFLVISCCSRRGYQQRARAIAEKEKRDEDKDKKKMRGEVEGKLDFEAGDRAEPFRGGAQWQKFASATASRPSHLRNRTTSRGSVEVSLVNALAASAVWNGGGNDELSECGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLA0</accession>
    <name>K1VLA0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pirin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLA0"/>
    <dbReference type="STRING" id="1220162.K1VLA0"/>
    <dbReference type="eggNOG" id="ENOG502RXW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064194_3_1_1"/>
    <dbReference type="InParanoid" id="K1VLA0"/>
    <dbReference type="OMA" id="THHHREF"/>
    <dbReference type="OrthoDB" id="10261807at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="275" mass="30231" checksum="083F44A56DDE3CC2" modified="2012-11-28" version="1">MSSQVSFQYRPTQTRGGADHGWLKTLHTFSFASYYDPRFESFGSLRVINEDRVAPGTGFPTHPHREAEIFSYVLGGTLAHKDSMGNVEGMTRGDVQMTSGGTGIRHSEYNGGKDEVHFLQIWALPNARNLTPKYYARHFSDAEKTDKWAHVVAPTSFPGVIDERDAKGPTPIHADLNFFATLLSPGKELNKEVTDRSDNKPGDKLVYVQVVQSTKYNTGPALKDGAHVEVSLGGQNQVLGEGDGVFIRGAKSKDEVVVKNTGTKVAEVVLFEMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM03</accession>
    <name>K1VM03_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM03"/>
    <dbReference type="STRING" id="1220162.K1VM03"/>
    <dbReference type="HOGENOM" id="CLU_330441_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM03"/>
    <dbReference type="OMA" id="VASIVCM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="868" mass="94419" checksum="85432D348DB76998" modified="2012-11-28" version="1">MLYAQPTSPPSPRSPAPQSHPARPASLASSIEEDDLYVSPKASPPYDTPPPPPQPQPAPPSQLAPSTMSNNDAPYNSNTLSGDFSALSDYNTWSAAMNAAPADPGAMAARKASETSNGSAGSKRSLPQPPRSGSTETATTTATAATTLPRKNSLQPTLSQRYQQLKERSAASAARRASQSSDGHTFTTSWERRGSERSDDFQSSAGYGRLPALEDVQAQQLQQRRMVSSPEPAHPPAVYETQNSHPPPPPPPAFHDSTPPSAFQSNDRQGSLPPIPLSSGNSEISPQQSPTRRDSLPPIPSESPQTPQRRASNALPPIPSGTAPTSPASPAQRRPSVPQANGENINGGMRDFMPYASVYGGVDGEDDLSASASRRNTLPPLPSVPKEQPLEPKSQAQLYAQQQMAQQRQQAEERRRQEEARQQAQQRQAQQQQQQQQQRTPQPPQPLRSPVYDSDKDQPPLPSPRNAPPSGPPTPGPPSAFTAPNPPLQPGQTNSLPGRRTTLGHGNESYTAQQQSGLSHAQTVRAPRSYTANLDRPPATPQPVGTPQRNRPLHPEFTHGDLTIQVSTPGPTDFLVSYTVLTTASGLIASTLAQFPAGKQPRVAITESVSEARLLLSALNYGNINHSSLAVAERDPLGVVEYLTLLRLYRKYQVSAFFTDLLQYQINQRAVELSQALTRRDRPLTLDVIRLAVEAKSSRLWDMLNKYSAYWFEALAPARLSAEEKDRVGKTGLEVLIAWNALRLGCGDRPDAVKVGYEGGRVCIWRVKDEKRKFYPVIKLETSFGNLPEAGRQSCPMGKGEGGRRKCHLVASIVCMYDFIISTSKPFTVLMEDEPEELGERADAEVELSTEEGLRNQRDVHDNGSRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMP5</accession>
    <name>K1VMP5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMP5"/>
    <dbReference type="STRING" id="1220162.K1VMP5"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387797_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMP5"/>
    <dbReference type="OMA" id="FATPMDI"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="343"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD05475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="590" mass="63464" checksum="B031E1D6EFE73307" modified="2012-11-28" version="1">MSHQHSSPPLPNLQSLSINPSPYGEYPYNNVFGPPVATPSGAPTRGWTSSPKQRGSRSGIPSAWFDPQVTENGGGGHHYDVFRRGDGASPTISAPSTASSGATPAQPYYPAFSIDPFPSMGLAPSPPPSVPYGMAPGSAAFAPFASQHVTSMPQRPTQWRGMIPTPDDDVIPTAIVIKNIPFAVSRETLLAIIESLGAPLPYAFNYHHDNGVFRGLAFANFRAPEEAASVVAALNGYDVQGRKLRVEYKKVLQPGEKDRIEREKAIKRMKSMQLDSVKTPIEPSHAHNNAHNNSHGNSHNNMQRNGHHQQVSYGDSSNDDRSPTQSSGSNKSDTLPVSLDLNDPATLSIYNMVYMFKEDRMRDELVLSRNLSPTERRIVHLVAQKLSLTSVTKGDGDAKHVVVTKDTPKSTQSTTHTSYLQPYPEGNGHGLRIKKSMPDLRGFNGPVVARDPARSLTPQRSSGNLRETAVAGVVGGRDYSSMGASHGRRLLGSGTFNSFFGAPVGAPPVPPLPASLSDLHGDSGSQPLRNPRGPVGESRGFSSGTFPRVASSLRGVPGSLALPRDTLSRRLSEEDEQDSSRANAREELDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN72</accession>
    <name>K1VN72_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN72"/>
    <dbReference type="STRING" id="1220162.K1VN72"/>
    <dbReference type="eggNOG" id="KOG4751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013527_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN72"/>
    <dbReference type="OMA" id="EREINRC"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="748" mass="81803" checksum="567602E5B9E36B37" modified="2012-11-28" version="1">MMHPTQETADPPPSSQPHPPSDDPFDDFLSPTPIPAVIPATVSFGTAGGKRLKGPSAAALQRAQKLMREAEREVEEQEAKRRKTEEEREKKAEEVLKGFPPAPSSSSSTSRDGTIAHGSTSRPPPPPETPTSGFSLGTGGSAPRPSAERLAAARALLDQPASSSPHTVSSPTRPSPPSGFTLGSGRSAPQPSAASLAAAKALFDEPAPGSPKPPPTPGFLLGTGRSAPQPSPANLARARALLDDEPLTPARSTPSRAPLRPTTNTFDSPVATPMKAKLGSLGSPATPRRIGLGSPARGRRKPFSSPFKAPGAARPLPGSGLRAPALVPPKPERIWKSVFDLTPPPERQNMRDAGLQPGRYSISDLEKLEIEIWQLDVDNAADYEFFEASAGVRLGVRQAFDVLKADGAELATERWVTNHWGLILWKLAAQVRAKPSLIDEKFTWTETIHQLKYRRHEARHRGRTAGNDGTEVLDAYGKSYLSISGNSTHPAPWDARLGVQRAPFVCGLSSLAVDGGVVALLDVVVSFAHPIGFQNKNDPRDTWNEDEEEVRAREYKYESEWNRLQEDMRRNLERAEELASLLRDYAEDVDYVAGSQPPDDLDGHYDELLESPNPSGVLRKLSGALVVHLARYAARRYNEAVQEERCVIESTLRERCPPRAVRNFRIIRVEDARLGSKPKRRTCQITIPDAVTCGLDLSVGKRYQISNLVPNRRGDWRWPVRQDATAEIALHARRNTRWKLVEDGESKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNE3</accession>
    <name>K1VNE3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNE3"/>
    <dbReference type="eggNOG" id="ENOG502RB7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538627_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNE3"/>
    <dbReference type="OrthoDB" id="2573545at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="436" mass="48681" checksum="7849CAE691E75884" modified="2012-11-28" version="1">MAAVYMPHSHMDQVHVAPRDHHNQMCSSVAYSVAEAALEPSPTSPSYNQRPALPTMRGSAPLRDVLVDHNMSHNTLASGWHQPQKERRASSFGGDRSRPLWEVVEHARERRERQQTMPELPVRSSTTPPVIRRILSQQNVMADPEFIQELMLTTRSADPSPTESAFLLQDTNNNLPRLSARDFAMNAEKTAATTAHTRTQSDIHQTPSQVLRSQASARFRPRLPSLAQIHAKVSRDQLRSDSLDSQDSEGPSTPTEEAGGFDIYHRQPCTPPSPLRDSRLAPFLRERTHGRLNGRPKSVPTMSSDLMEELDEQIQTPPMFTTPPRLNTTNLSRRLAAAALRRGSDVQLVVTPPKAIKTDTPCSPTESVLSTASSVPSLPIITCTPAAEPDSDEESEGDVIVFNGEVEAIEDEEEEERREREMRGREMLSRLLRRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNE4</accession>
    <name>K1VNE4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNE4"/>
    <dbReference type="STRING" id="1220162.K1VNE4"/>
    <dbReference type="HOGENOM" id="CLU_1062403_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNE4"/>
    <dbReference type="OMA" id="IVELCHA"/>
    <dbReference type="OrthoDB" id="58379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="262" mass="28721" checksum="15A44E45B4555EEE" modified="2012-11-28" version="1">MSNSILSPLSPSSLYSPPLPTSPPAEAPPEMSIDDELPSYSDTLRSGPAKYACLMLSGTDRIQAISFPYNRRTRDLLVSALKVGQGVANCDLPEDGVWDFKLYGKPWSLDSLDAVRAPHILVSLYTTLATAGWHPSASVDIVKKKTSHDSIYFRTGPRIPREFFAITIEESDKLRLVDAPCQRVKDAFVGACASQTVQEKEMGSLVVKFSGTPWTAWKGDNTRGARRVLAAAMERLETAGFELVSSVSLSGRVMMIFGTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNH5</accession>
    <name>K1VNH5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heat shock transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNH5"/>
    <dbReference type="FunCoup" id="K1VNH5">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNH5"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015858_1_0_1"/>
    <dbReference type="InParanoid" id="K1VNH5"/>
    <dbReference type="OMA" id="RMDHDNE"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="595" mass="63464" checksum="E31FD0B9719B6AD0" modified="2012-11-28" version="1">MTTNLAAIAGPSRYNQVPKIEPVSPLNSISTTPNNNDADGPAPPLPAGGVSKPGLSVGENGEVVKVPAFLNKLYSMVSDHDTDNLIYWAESGDSFFELLPRFFKHANFSSFVRQLNMYGFHKVPHLQSGVLKNESPSELWEFVNPFFKRDQPHLLARVTRKNNRPAASSAPTPSQGSTGTRSSARQAAANALSSNGVHLLTDGTIEGEAGQLVGPSGQLADLHAIQNGINAIRQTQAAIGADLKALQASNEHLWREALETRDRQQKHEETIDLIVTFLERLFGTEGEGLKGLKEAMRRGGMGTRGREESASDDTSIKKRRRLMIEAADAVAKGDETGRFVEVQEPTATIEPFSTAPSSTRSSESWSTGQRFQSLPTDDEASPKSQPRSNSLKQGATPAGEQTLHQAAISPMSDAPELPKAAGPARPPANGNDATGLNLDSNLLQTTIGSLLQSPAAAQMFLNSLNASSQGQALATPQKGVKPSPTIGGEQSADPTLALFSPLPNHDGLVNNQHELLGAYQKAVGVNNDVNKLQESIDSLVRSMGLDLPDQQNPHEPMPVSCGPEGAYTDGDFNVDELLDQLTANNEHPVPADASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNN2</accession>
    <name>K1VNN2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNN2"/>
    <dbReference type="HOGENOM" id="CLU_174720_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNN2"/>
    <dbReference type="OrthoDB" id="10407617at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="102" mass="10976" checksum="048CFA2839FAD537" modified="2012-11-28" version="1">MTFSPEIVSHATTHMNEDHADGNLYIVRAFADEGAKSATMTTLDGESGTWSYVAADGSEKTATVPWPAGPISERMQIRVQVVALYKTACAKLGVDVKPHPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNP0</accession>
    <name>K1VNP0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000295">
        <property type="protein sequence ID" value="EKD02231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNP0"/>
    <dbReference type="STRING" id="1220162.K1VNP0"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1215532_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNP0"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25387" checksum="32D5C41FF927BA4B" modified="2012-11-28" version="1">MSALFAQRREEEAARRDRSLAEFLVMLDGYKPLIPEEVTEYYLQRAGFDCQDPRLKRLLSLSAQKFISDLSRDAFHFAKLRVNGTTAGRGRPATAVDRNRVVLTMDDLSLALSEHGVNVKKPDYCELPVSSLSANIQTCNHPSPLLLAWSVTPSSDALRVPSADILSCLYFLPLDHRVSLYQLNQHAMSRQEKLECMQLMKKMYTMVSPTGPAPCLAAESPASIGDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNU4</accession>
    <name>K1VNU4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNU4"/>
    <dbReference type="HOGENOM" id="CLU_1563989_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNU4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="171" mass="19290" checksum="122EB383A99D365B" modified="2012-11-28" version="1">MKPSTKDEEGYTYTAVNPQDQAQIDRYVEVYRAWGERQPVSTSDLERLRIRLAQMQARCARLTIWGIDTITLASGALVAMDMSHRALALIYNSMDPDDPWSAGRALGRIYGCKLLSNMPWSSQRRVRRNVAYAVVLETAYMTAVSYQAELGSSHHMLFVSSERLGVAHPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPB4</accession>
    <name>K1VPB4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPB4"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001051_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPB4"/>
    <dbReference type="OMA" id="DSAKEQC"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="1665"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="1799"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="1917"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1690"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1825"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1941"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="609"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="774"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="901"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="927"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1018"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1054"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1074"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1146"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="1951"/>
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        </location>
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            <begin position="1964"/>
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        </location>
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            <begin position="1983"/>
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    </feature>
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            <begin position="2061"/>
            <end position="2077"/>
        </location>
    </feature>
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        <location>
            <begin position="2078"/>
            <end position="2096"/>
        </location>
    </feature>
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        <location>
            <begin position="2097"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="2117"/>
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        </location>
    </feature>
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        <location>
            <begin position="2165"/>
            <end position="2189"/>
        </location>
    </feature>
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        <location>
            <begin position="2190"/>
            <end position="2208"/>
        </location>
    </feature>
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        <location>
            <begin position="2216"/>
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            <begin position="2232"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2271"/>
            <end position="2323"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2356" mass="239009" checksum="54E329957B2EC335" modified="2012-11-28" version="1">MFGSNSFGALAVETPPSGGNAGSEPTEGEEIDVDLVRSNPHDANVRVGPKVDLNGLPSESSLLAVSNRNDLLAAGGNNGLQARIGARADAEPPWTPDLGQNDERIVVVSTGGILLFKTADVLGGNTAPYATITTGLPNSLLDVLPNPGADKLGAYVALVSPEGMVLLDVDEAKVSAPLPGPFTAASWSAKGKQIVLGTPGGKLVQYTPEGQAKAEIAPPSDMENPRPTFVQWLENDLFLVGYAMEGADQADPLDLYVVRRSKTGCTYVKFWDVNNSMGYSGRSGQHRHFAGLKDWGDNRHLSFLLSPIASEIGVLRGTPTDWQSLVLEETARGIMPAASVGTDDTSPLGLALDLTSKKPIKRGIVNGEEQPDLPPCPRILAYSQEGIILSFDIRIPDAGAYPNMVTPGAAQPASAAPSTAASVATSPEKKPAFGGFGSGTPAFGQSAFGKPASGSAFGQSAFGTGSTTPGSSPAKPAFGGAGAPSFGSSSFGQKPAAQSAFGSSAFGSSTGGSAFGQSAFGTTTPSGTPAKPAFGASAFGSTTPSTTPAKPAFGGFGSTTPASSPAPAFGQSSTPAPAFGQSSTPAPAFGQSSTPSAPAFGQSAFGQKPAGSPSAFGQSAFGSSSTSSAFGASAGQTSAFGSSAFGQKTDASKASGFSGFGQKPATNSAFGSSSAFGQSAFGQSASPSLMTRRTAKPAFGASAFGSTTPSTTPAKPAFGGFGSTTPASSPAPAFGQSSTPAPAFGQSSTPAPAFGQSSTPSAPAFGQSAFGQKPAGSPSAFGQSAFGSSSTSSAFGASAGQTSAFGSSAFGQKTDASKASGFSGFGQKPATNSAFGSSSAFGQSAFGQSAFGQKSDSKPAFSGFGQQPKPDDKKEETKDDKKEEKKDDKPAFGFSGFGQKTDGQSAFGASTFGQKTDKPAFGGFGQKSEEKKDDKPAFAGFGKPAEKKDDAKPAFPGFGKPASPAKSPSPSPSKEKDSFGLGDLGAAITKPTGIESPPSSPGSPVASGGVPGLEDSPPSSPKPAAKPAPTPAPAPTSTSTSSWIKPATAFGSSTSGGFGAFGGNKSGSAFGSGSAFGSGGAFSGGASAFGKPSPPASGQTSPTRTGAPAFGQSSVPAAPKFGQSSTPAFGQSSTPTFGQSSTPFGKSSNPASSSTPTPSAFSSTGGFSGFGSGTSAFGAKAGQKSIFDSAKDDKKDDKKEEKKDDAKDVKPEKAAMPAGYDVPASPNKDTKPESSKKEEKKDEDKKAETPSSPKKDDKKVESPASPKKDERKDDAPKPEKAVMPPGYDSPAKKDETPAKSEKDEKKSADLAEAAKTPIKSEDKEATESKPATPKSFADAVKSPSPAKATALPDSPDVESLSDDDGDDNHVHVHVHSATVVGPDGEEEYDYYNGDEDDYDDEEYDEEEDEGEFDDDDEQEDEDHLEELEDEVDEDAEAASLGTIPEDEEEEGSDHSDDKPEKSPKLPKSPTWFASDSPQKKDQPLPSLLSRLGPPVNQKDDEEEDEEDEHDDEDEEHDEDEDEDEDEDEDEEESPQKDDTKSTPSSKPSLLSRMSPPAKGVESPIPTRTVPPLKHAPKTSSPLALTKSGGDGDDTEEEEGHEPGETPSETPETETDDDSGARKDSIGSVGLNLASSWGNKQGKKEKEKDDSGDKPKFSFGAKPAAGEWTCDTCMLKNPDSAKEQCTVCEAPRPGAKPAAKPAAPPGPPAPPAGGFSFGGFGKKDDSSKSGSPTPPASGGFSFGAKKDDTKPAAPSFGFGKPPAPPSGGFSFGQKSEPAKEDKKSDSKDDKGAKKDDAKGADWTCDTCMLKNPDSAKEQCTICEAPRPGAKPAAAAKPPGPPAPPAGGFSFGGFGKPAEAKPAEEEKDTPKPAFSFGGFGQKPEEKKEDKADDKKDAPKPAFAGFGKPAEKKDDAAKGADWTCDTCMLKNPDSAKEQCTVCEAPRPGAKPASAGPPKPPGPPAPPAGGFSFGGKPVTPAASSTDKPAAAPAFGGFKPPAPPAGGFAASPAKSPSPSPSKEKDSFGLGDLGAAITKPTGIESPPSSPGSPVASGGVPGLEDSPPSSPKPAAKPAPTPAPAPTSTSTSSWIKPATAFGSSTSGGFGAFGGNKSGSAFGSGSAFGSGGAFSGGASAFGKPSPPASGQTSPTRTGAPAFGQSSVPAAPKFGQSSTPAFGQSSTPTFGQSSTPFGKSSNPASSSTPTPSAFSSTGGFSGFGSGTSAFGAKAGQKSIFDSAKDDKKDDKKEEKKDDAKDVKPEKAAMPAGYDVPASPNKDTKPESSKKEEKKDEDKKAETPSSPKKDDKKVESPASPKKDERKDDAPKPEKAVMPPGYDSPASLRNGQDKMRHQFLSVSASRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPR3</accession>
    <name>K1VPR3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CnHHK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_04304</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPR3"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_4_1"/>
    <dbReference type="InParanoid" id="K1VPR3"/>
    <dbReference type="OMA" id="WHTNSES"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
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    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
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        <location>
            <begin position="902"/>
            <end position="1064"/>
        </location>
    </feature>
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            <begin position="1305"/>
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        </location>
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            <begin position="1732"/>
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        </location>
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            <dbReference type="EMBL" id="EKD01462.1"/>
        </source>
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    <sequence length="1898" mass="205053" checksum="CDD1D027C9337670" modified="2012-11-28" version="1">MSRPSGDIDPPDVEAEGSRERLREVSARSTSSGAGRSPPGANTYVFPIRSVYQREQALQAREDAKHLRTSPGSPSLALGLSDAIFHAPPSPRPSGLQRASSDNIHDTIHEMLEHRGDLASNRTMTSMSFIPKSSSSRGSLPSPTFSGSSSLPNVSAESPPAFPEFNRPSFSARPTAVRVPTVTSSSSGGTSGAQALSSGEQGSKDSNELGVPISPITSVSQDPLSMPSVSPPRKASATTMSSSDLPVTPATGSIGNPAEPPPQPQTNDEPGSGILEAADTDGSKSPVTRLEPNEEGLPSLVNDFMDIIRLDGAVQVPSPSSNDNSGRSGRSTLHQPNVPPSAVSRIASTMIPNSTNLGPSIIRHDQSVSGSTPSRSTRNRAAQAQAMREQKEHSVLDFINEQARTVQISDPNEASPSTSPVSDSEMPQSETCSSSQEDFHIYAPKAERWNEGQGKAESINTSPSSDQRRSDNSTTVGSRTNTGTNTGTTGTGTGTGTGSGSRLDSALATSSDLDSPEPVVTFRFQHVQRDDGHHVITGREGAIVRCEDEPITTPGAIQSFGVLMVLEWDYESGNLMVRQVSEVSLQVPKYLFSLDCFTEALPPRQADILQDTIEGLGEAIESDSEAKHANEGPQIFRLSGYSETDAPDDPTVLGDSASATGSRSTQSSTWRTEWTCWVAAHRPRQPQWNRRDENGNPVPPPDLIILEFELETDVFNPLTRPAKGEGMTSDFPTPNSRLAQLSSTNSSSSIRPTTAPTTSPSSDEHFGRVRRGSSGIETESTVPTTVQSDSVSSIFSPMDDDCQDVPMGIDGKNEDVPLERILASTTNHAKPLRGIGVQRQLRDLWHTNSESGSSVQSAARGTRRGRGGRRTRRRTGASSVTDALDVFSVLNQVNDQLGSAQDLEHFLNIVVGVVKDLCRFHRVLFYKFDEDYNGEVVSELVDWGRTTDLWKGLRFPASDIPPQARELYKINKVRFLYDRTQKTSRLVLKDKSDLEYPLDMTFCYLRAMSPIHLKYLANMEVRSSMSISIMAFGKLWGLIACHSYGHHGSRVSFPLRQIFSLMSDQISRNIERLTYAHRLNMRSMIHGAANAPGPAGAKSKKSKRRGNQSSDGPESSASSSSGSYLVSNADALLTVFDADAGLLVINDGCKLLGQSEQGHAMLAIAEYLRIAKFTEIKSSFNIQKDFPDLVLPRGTDTIAGMLYIPLTTEAGQDFIVFFRKGEVYTIKWAGKPYRDPSQVTAAVLEPRASFKLWTENVTGRSRVWTDDQLDAAGVLSIVYGKFIQVWRERQNTMVSNQLTAILLSNTSHAVRTPLSQIINTLELAMAGNIDSDTRRMLENSHQASRALLFHVHDLLDLTRIETGNETAFSDPFDLKQTITDTVRLYETESKRRGIDFTVNVDDALPRMVIGDSRKIRTLISNLAANAVKYTKDGYIDISCRIEPGTEPMPSHAPGEPGVVSVEIIISDTGCGIPPGKLESMFITMEGAEDRKEGGVGLGLAVVARIVEQLAGQLRAESEVNKGTKFYFTCNMGILEDGQVVRPTALGDHNYIPGSSKRLIGGTPSIGSSLASSRHSKSSSKSKRSSKSGKSSKSGKSSSSKSGSSKSGSKSGDSASKVSTLDSGERSKSTVSQDSSGVASASFPTADLLKRRGITPSASPNPTTTSKTKSKTGISSAASPDSDLQERGSLKEGEVKEVAAPTSEKAASIAPSTITERPILRQRKSPKGLPILRVLVVEDDIVNSQILQKRLRMEHHNVIAVTNGQEAVDALSRDWDIDVVLMDIQMPIMDGFQAADEIRRLESRINTLEGIDPVRVDGRIPIFAVSASLYEHDRGSLSKNFDGWILKPLDFARVRSILSGLEDDTKRDAEVYKAGHWEAGGYFNGANPPAASGTSSTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ49</accession>
    <name>K1VQ49_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallophosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000380">
        <property type="protein sequence ID" value="EKC98827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ49"/>
    <dbReference type="FunCoup" id="K1VQ49">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQ49"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432918_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ49"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="144"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="654" mass="72130" checksum="476A57FD87A116B7" modified="2012-11-28" version="1">MAFRSAASQISGPSSLPPPTTTTFTDHDPAAIPSSLRPLVDNIIIRPWLTLRGRGRPSTPITPPFCQNRENRDGTADQVNSWLSASAGLFSWSGMRLVTPVNDAIEAFRAQLTAQVGTFYSSLSSCRFPDSTLRATSGGAKPTHVAIIADPHLPHPQFSHPEESSSWVNSVRQGFDELFMRKSWSILNRIGRIDAVVFLGDMLDYGREKMTDAEYDDYFQLFKRIFEPSRGTEMYYLPGNYDIPLGNPGNMFEQAARARARFTNTFGPLHSVVNVTGHSLVLLDSIGLVEEDYRRYGAEVNFEEYNGDDSSVIEFIKRIQADPLPSPIVFSHIPLSRPESAKCGPLREGSEDAKIRKGVGPGYQNLLGRQTSNFIVDAIDPIVVFSGDDHDYCDMVHADTGVREVTVKSFSPSTGVNRPGFQLLSLVPPEANMTTYADVPCILPDQTHVYRWVYLPLAVVTCAWLFFTNARHAWARSGADLKAKGSAYGASDEKKAVLSSWGSSTRLRPQASGPSSPLLSPRMNTDDPEQGQVYDASPLGSRQSSHLDLTDQSVIRRTGSGASLLPGGGGMSARRNVNLPRIKSATDWASAAKKDKPVLNLMLDPGAKRSRVRAIGRWLWRSRRSVLVRTWTEMITIFAPALIVWFGLNALFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQF0</accession>
    <name>K1VQF0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQF0"/>
    <dbReference type="STRING" id="1220162.K1VQF0"/>
    <dbReference type="eggNOG" id="ENOG502QWF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029472_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQF0"/>
    <dbReference type="OMA" id="KTVRCEA"/>
    <dbReference type="OrthoDB" id="2538408at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="356" mass="38748" checksum="D7B2A915BD1BE688" modified="2012-11-28" version="1">MDNNESFERPPSLPQQPARPLKAIYTVFTSPHHAPMPNHLPTLIVTPHGQPNQILYTYLHTEENRVNYLLTPSPQGDLCVAKLFPPPRTGATSSASLPTMSVKHNVVRCEASRDLKWTIENTGVMNPTYKIVNQDDTPLYQISKPNPHADWWTMFYFKYAGHQIPPKRVEFGKVSKNPPEKGGGTRITITGRSEDEKAVWQTLGVGNEDCVEWVVCCACLNLLDDQILKAAERKQTGAGPASTAPSPMAHSPAVSARASPVSQRSNGYPNGGQGRMGPGIASTAGPGIASTGPPGGYRQQPPMQRPPPQQQQQQYRGPPGGMPPNGGGVHIPPRGASQQMMRGHPQQMQQGPGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQX1</accession>
    <name>K1VQX1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQX1"/>
    <dbReference type="STRING" id="1220162.K1VQX1"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_3_1_1"/>
    <dbReference type="InParanoid" id="K1VQX1"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="36"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="253" mass="27404" checksum="56C70DAE6784209B" modified="2012-11-28" version="1">MLAAARVLPVVSRLPLRATVRLASTTSVMMPIEPKDIPTVSKQGLGKRLSIWRAEGTRLTGRGCSKWRPAAETLPLLTRQIDMIVNAANKSLLGGGGVDGAIHRAAGPDLLRECRGLRGADTGEVKVTKGYELPAKYIAHAVGPIYSESMKEMCAAQLENCYRSALEQCSDIGCTEIAFPSISTGIYGYPIEDATEIAIETTKDFLEKDDKVSSTGVVQTDRQVKQVVFCVFSPEDEEVYKKLVKSIVPTNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRH6</accession>
    <name>K1VRH6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BNA4</name>
        <name evidence="13" type="ORF">A1Q2_02610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRH6"/>
    <dbReference type="STRING" id="1220162.K1VRH6"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023210_2_1_1"/>
    <dbReference type="InParanoid" id="K1VRH6"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="13"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="497" mass="55139" checksum="419F9281E63D965C" modified="2012-11-28" version="1">MTIELNPERTRRALVVGGGPVGALTALSLEKRGWDVELWEARDDPRGRTIAMTNLRSINMNISSRGLAALASVDPALADLLLSESIPMPSRLIHHLDGHREAQLYDPLRGQCSNSISRSVLNQRLVEALPKSIQCRFNTKLVRVDWANNVAYGRETRPGAALGTEQTSGLAEGSVEVPFDLILGADGSWSAVRGQMMRASRVDFAQSFIAHAYVELHMPPINDDWAMPPNHLHIWPRRRFMLIALPNKDKSFTLTLFAPFEEIAALETRADAEAFFSTEFSDAYKIVGSRMVDDFMSNPRGNLVTISCKPGTYRDRCALLGDAWHSMVPFYGQGLNCGLEDVRVLGSYLDRFGVGPTTTNKQGETDPNLEACLATYASERSADLDAICQLAMDNYTEMRSSVLNPLYHLRRAVDYTLTRLIPSRPAALDGPDPFPTKTVRGWTALYDMVTFRPDIGYAEARRREAWQKHVVHSAAYAGLAAVVGAGLFAARHFQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRN8</accession>
    <name>K1VRN8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRN8"/>
    <dbReference type="HOGENOM" id="CLU_2185777_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRN8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="109" mass="11903" checksum="C883DB3F1958D5F3" modified="2012-11-28" version="1">MLHAGCGACGATRPRDRAKGRRSPAGQASAQSPVHRVAAWPYGMCTQGAGRKSDPETVDPEAWTLTRRPPEDPKDPENLEQSTGEPLHALHKQSRNRNLWEAVTLAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRX5</accession>
    <name>K1VRX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRX5"/>
    <dbReference type="HOGENOM" id="CLU_638075_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRX5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854321" evidence="7">
        <location>
            <begin position="18"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="451" mass="46919" checksum="E798BF2CDCCCDADF" modified="2012-11-28" version="1">MLLPVLVASFVLLQASALEYTYPLSASDPFLVVSPQPELRNTSLSTNATTFSARSGLQISVNTPLIGAQFEGRIVSPSSANLLLQTGKQRKNEIARQGEWDTLIGDSFPASEGEGGTKLSTTFDGDLVLRQVSLTFDLVSDRTAFNQQQSDEQPLVASDGKLAPGPQFDGDWSVAETSIGSYARGKGSVSIPLLAGTSFAVLTGVLGKDMGDYSATLVPAREGAKEGNVTYSARNAEDGTGVLWLGALDPGTQHTLRLESAQAMGLYKLRQYGDSLAVVSGSSSSSSSPSGSASPSPLSSVPAASPKSSTNIGAIVGGVVGGVGGLLLIVGAVLLFRRRQRRQPLQGPIEEEVKPEGEYRAIVEDFVTPYTLSGGSTQSPSSASGKGGPTMPASTQARPNLHVETGVREADAGPLPEEPEQTLPPLYDPTWRSASSPSAPSTPVASTPTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSX9</accession>
    <name>K1VSX9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSX9"/>
    <dbReference type="HOGENOM" id="CLU_1579617_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSX9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="169" mass="18123" checksum="14408E527B2D81CB" modified="2012-11-28" version="1">MKMAPVSNGTLWAIIGGIVGPVILSVLFCIAISVHSARREARDAARRLSSSGAPTTEIKINQRRLEIRRMVRAQYGVGGVARVESRSSDAPPTYGNSWNDTTLEYGDGVMPPAPTYWPGSRPMSVASGKSVATSGSGGSRDTVDSLESAPSLYVDAESERRDVEQIQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTH1</accession>
    <name>K1VTH1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_02826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
            <location evidence="2 12">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTH1"/>
    <dbReference type="FunCoup" id="K1VTH1">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTH1"/>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070944_4_2_1"/>
    <dbReference type="InParanoid" id="K1VTH1"/>
    <dbReference type="OMA" id="THEKHCF"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0243">Dynein</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="78" mass="8775" checksum="97E71680C96B9164" modified="2012-11-28" version="1">MSAPSSEKPSDVKAVIKSVDMSEEMQETATQMAVTALEKYAVEKDVAMYIKKEFDRLYNTTWHCVVGKHFGSFVTHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTM6</accession>
    <name>K1VTM6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000351">
        <property type="protein sequence ID" value="EKD00048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTM6"/>
    <dbReference type="HOGENOM" id="CLU_2387725_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTM6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852093" evidence="2">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="94" mass="11137" checksum="DACB774BD8A1B218" modified="2012-11-28" version="1">MKLAAILLLSIAGAMAAPIEDRDFWNGAQKWKRDDADAEKRDFWNGAQKWKREDAEERDFWNGAQKWKREPDEEERDFWNGAQKWKRADSHGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU29</accession>
    <name>K1VU29_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lincomycin-condensing protein lmbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU29"/>
    <dbReference type="STRING" id="1220162.K1VU29"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_3_1_1"/>
    <dbReference type="InParanoid" id="K1VU29"/>
    <dbReference type="OMA" id="EGNMVSY"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="568" mass="61108" checksum="BC98B87077923BC2" modified="2012-11-28" version="1">MTRASCTSPRAAPPSSRRRAWSRAPSRSAGLEILNKGGNAADAAVAVAAALNVTEPTCTGIGGDIFCLFYDAKTKQVSGINGSGRSPAALTLEHLRKQGITGNTIPLNNMNSVTCPGAAAGWWKTIEEFGSGRLKMPEILAPAIRMAKEGVPEHEINANAWEHQEQLLKDASPNWKEMMMPNGHAPLPSNIMVHPELAETFEAVAKGPEHFYEGRIADAIVELVQSGGGVMTQEDLKNTRANRTDPISYTFHATKEDPGVTLNEHAPNGQGLVALIALGIIEEIEKLHGFQVLELEHNSPEYLHILIEALRLAFADAQHYVADPDFHKTPVEELLSEPYLRSRAKLFDPTKASNPVNGNPFACTDTVYFTTSDNEGNACSFIASNYAGFGTGAIPKGCGFTLQNRGAGFVLQEGHYNCVAGNKRSYHTIIPSIVTSGDELVMSMGVMGGYMQPQGHVQVLLNTLRGFSPQASLDAPRFCISAGLPDAGTKNAKDAGNFNAEIWFEEGIAPETVEKLRQMGHRCEVADHFKRAILGRGQMIRKVTDPSGRIVWAGGSDPRADGCAAGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUH8</accession>
    <name>K1VUH8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="5 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_02601</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:31240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="5 14"/>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUH8"/>
    <dbReference type="FunCoup" id="K1VUH8">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUH8"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUH8"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000008">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD03152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="387" mass="43307" checksum="09CA110BC33404A9" modified="2012-11-28" version="1">MTTYKIPDLKLNNSWRELQKELPHIKNDLALRAARGEETPRAPVWVMRQAGRYLPEFLEVRKHHSFFECCRKPELASKLTLQPIDRYPNLDASIIFCDILVVPQALGMEVIMEPSKGPVLPAPLRSPADLARLPDESSANHQVDVQKELGYVFEAVTMTRKGLAGRVPLIGFCGAPWTLMAYMCEGGGSKTFEHSKSWLYKWPEEAKALLHKIADVCADLLVGQVLAGASMLQVFDSWAGELTPYQFETFALPPLVHISRKVNYVLTHLGHPTVPMILFPRNVHSPQSLALLKPESIGYNVIGLDQGLDPVEAKKALPGMNLQGNFDPAILYGGKEGIEKEVERLCKRFHQNSGGWIANLGHGITPNVKPEDMGWFLECVHKYSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUR0</accession>
    <name>K1VUR0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUR0"/>
    <dbReference type="STRING" id="1220162.K1VUR0"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_7_1_1"/>
    <dbReference type="InParanoid" id="K1VUR0"/>
    <dbReference type="OMA" id="FRECAMF"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="133" mass="14771" checksum="BBA3A93D7909DACB" modified="2012-11-28" version="1">MAVTKEQYPEFMKMAAIVHLPTGKVLAKGHNQRVQLNSNIRHGEMDALENLGRVNEGVFRECAMFTTLSPCIMFPLVVLAENENFVGGEDLLRSKGVEVVNLQNPEITKMMSDWIAGPVGQKVWNEDIGEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV66</accession>
    <name>K1VV66_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV66"/>
    <dbReference type="eggNOG" id="ENOG502RB5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354954_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV66"/>
    <dbReference type="OMA" id="SHEHTID"/>
    <dbReference type="OrthoDB" id="2565067at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="392"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="791" mass="85879" checksum="5305546D8B5257BF" modified="2012-11-28" version="1">MSTRRAGRGLKVAHPAAPTSNRLLSTQTFTLIASWKGQLVICTVVLVVGAIYFVVREPIREWRERQRERMSRAFTEELLSMEKKEDGNVGSGDRNRAGPSTVAGTSTAVATAKTMNARERGREKRKEKKRKEHLQNANGHAAPRPPHEPGPSSKPSPSDQSPARVTETLPGPSTPSTADTRDASMTVTPASCPTSMGPQPSSSTSNANNEIADNTSSPPPQVGSELEVPSPPIVEPPASPETMKSHSPPLSPRKTHTSEHQPESFSPGTPERRDSHSSSRSRSYSIIPDPSYLPPHHHDSNNKKKKRKPKSRQASAQQQPQPQPPQSQQKPSITAQATPMSRIVTTSSEDAPRTDAPRTPRTPMIPIMSPDVARRRIRASGVELPPEVEVLLDSHEHTIDSLRAEIGRATAEECKARDDEVRAREELRRSRATEDRMRSDYERARKMRDRAEQEARRMEGEVQMIWNRFETLSHMYQAVCQRLREVEAAQQSDGTSPTGPTTPAPPQLQPLMAFANGIPGTPGVILPYHMVPSPLTPLGFGMPPTMYRRGDSASSEMLAGPLTPGHQPSTPSGTSSPYPSDLSLNPGSRTHTESGSMTTAELRRISIASSVLKKKKPSPSESGESSAPSAAATSSDDKSSSGVEGLGIRAFRDVSSTFPSAITMTPAKKHSTDSVDCSTASSSPPAERHILITPSESEHNGDHSPKSMSPLLNGRAMLDGEPEVTPKQLVDEPKSLAEPMFASLAHTPEQLAEIARMRQSAIRDRERKSRAASVEVKVNNSVNETANANDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV96</accession>
    <name>K1VV96_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000335">
        <property type="protein sequence ID" value="EKD00678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV96"/>
    <dbReference type="FunCoup" id="K1VV96">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VV96"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007339_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV96"/>
    <dbReference type="OMA" id="HEIFRAV"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="137"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="545"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="716" mass="78553" checksum="1D6F85D440734A25" modified="2012-11-28" version="1">MGLIAETEDDRYQSSRSVTYRSSGRVARDAKLRQQVLRADDRNGAGAFALPPPDNTICRDGTGAGGSDAAAGAAAAARDDWRGRGRVQGGRDGPEGAAGEGEQRDGGVVSFLALGPTDLSFANDPSKPPDRAIVGPACQVIEVLGGDYRKHIIERYIQLQLQDYRRIFRSTDEAGQLDNVPRRYAWFRRVLKSHDEESGSLFPDSWEVSRLLVASFADSTRADLTNVLLKTPPSVTVLLDALQATLDFEATYARRFGCSFEDITDRLDALNAPQQRFTISSAFDAHFGIFVDAQDKAIADTLGPHRGMRSRASFEGVSNDDEGATALVLPSSMELFHVYRAALDKCSQYTTGEPLQRLARVFAKWLKVYSDDVLLASMKKPAPADFLARRSVEGRSDLAEVRNACMVLNTAEYCLNTSVQLEDLVKEKIKPELADSISFQDERDGFNGAIAQCLSLIMKELENAVEPSFAAMLRTPWKDLENVSGRSAYIVDLVGSVKEIAAVVGTRTASPKYVRNFSDKCVNLIMGRFTSAIVRSRPLKKIGAEQLLLDISAVKGCLLELPPLEQGEKSHQHKKYVAKVTKATGELETMLKVILAPDEVPEGFVQNYCLLIGDRSFSNFQKILDLKGTLKGEQLQKLLDIFLAVTRTKDDLEDSSFLTKLDMDEKTTTGPTVGGGLFSSGNTTPTLGLGSKAPDRTETPKAFGDFRKFFRRDTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVY1</accession>
    <name>K1VVY1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVY1"/>
    <dbReference type="HOGENOM" id="CLU_2028347_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVY1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="122" mass="13381" checksum="47B9BB5288AF0250" modified="2012-11-28" version="1">MSLFRARIALRPVLRAPAPTLTRGLRNYDVNTPSETVADKLQGSEAPSIYNEQEVKEDGKPTKVGAKLEAQEDQAFARAEANAMKVKYNSSEDGKINEQDVDLGVNRNSDKGYNEPGSPNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWI1</accession>
    <name>K1VWI1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWI1"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_3_2_1"/>
    <dbReference type="InParanoid" id="K1VWI1"/>
    <dbReference type="OMA" id="FPEWFND"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="364"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="661" mass="75231" checksum="D45F48DB1066ACC8" modified="2012-11-28" version="1">MIRSTRIFIFLGLACFLFTLHLFYSEHHRQQPTQRSFTDDVEPVNYIGGGRATAAAAAARAAEEPASLYDNLELEQEYFTTDSRSQPQHPLKSPNQDFHYEGVSIDEKGLMAFDPALHDKHPVELLIERGRAQAKAIDERIASVKTLEDAVADYEKAWGMKPPKGFDNWFKFTQETGSVSVPSMFPLAHRPFEQFLSLTPKEIKDRIEVGANKKGPLWTFTFVPDGQGDEGTQTDEDGTWEPEDWHTRGRGRIKPSNTLTLILPILAKLPEEFFTQDPPVTMLFNNEDGPAGRIHQKVQERGETLGRAGKHWPETQLKAAEQAMRWTAGWHWTCPDGSPLRESAADKVLNDEGGSDSSSQLKTFVADFYKSTDICYNPEIRELHASAIADYRMPANPLVPQISVCRMMRNNDIVGVPLDAVYQNPPFVPWAQKSNDKVLWRGSPTGIFHNKQMPWRQAQRERLHFLANNKSDAAVPVLVSGLEGLRVKEFPVNQMNEAWFDIGLFGGPAQCSHEDGSCAEMDAEFEWRPSVRGNQALEYKYVVDVDGNGWSSRFRRLLKSNHVVLKSTLFPEWFNDLLVPWYHYVPIRFDYGDLYDVMAFFKGAPDGSTKGRDDLAEEIAKNAHTFVDSHWRVPDMESFMMLVMLEYWRLVSDDRKAMSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWM0</accession>
    <name>K1VWM0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_01875</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWM0"/>
    <dbReference type="STRING" id="1220162.K1VWM0"/>
    <dbReference type="eggNOG" id="KOG1573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050259_0_1_1"/>
    <dbReference type="InParanoid" id="K1VWM0"/>
    <dbReference type="OMA" id="HTSGAYM"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD03862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="304" mass="34630" checksum="C50680002A6F36FE" modified="2012-11-28" version="1">MRAPVVTDQVRLHATKLDAVSDEIDAVNVLKGSAAWDAASEFDKGKNKDDFRQYDDACDRVKAFYAEQHAKQTLAYNVSIREAHSARPKVKMSVWAALELLDQLVDESDPDTSVGQIEHLLQTAEALRRDRKPDWMQLVGLVHDLGKLLVFLGAEGQWDVVGDTFVVGCAFPRAIIYPDTFKLNPDSQDPGLSTECGIYERGCGLDNVLLSWGHDEYIYDVMRRQSSIPKEGLSMLRYHSFYPWHREGAYRYLMGPGDEEQLRAVRVFNAYDLYSKSDAPPDKVALRPYYERLIEKYCPGELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWY2</accession>
    <name>K1VWY2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000159">
        <property type="protein sequence ID" value="EKD05021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWY2"/>
    <dbReference type="HOGENOM" id="CLU_731946_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWY2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="378" mass="42338" checksum="F5EBD464C85EF017" modified="2012-11-28" version="1">MPATQLTASKKRKPAYNAGVKQMQRLRKTHAKHHFLSVKCDSAFDTVVIWSAVGPRAVPTSEEQAERFSSLVFQHFLKGDLYLECEGRQSSFVDPDTGAKQMVYWVPTLIPQGFSSSDPFNVSDNGSTEAGTSAAAENAGSFPFLPTPSDGAEDINKGNNKNDNKKKRKFWQFDDDVEDEQNKEQDKEGPEDDELDAEIVETSTAFPDVKILNNTAYHAAPKRRRVDDIGHPTDHVSYHPTGDEQQDTRCRRCKLYGQRCLHGSITGDHTHPTSCVGCASVKAECIFEHDNANPAVHGGRPVFYNAEKTYEGFLNDRNREMFDDFLHRFISIGIRDNQWRLEALDCFDGIKSQAGSLVGAVYFGRDGELNAEIYEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXG7</accession>
    <name>K1VXG7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXG7"/>
    <dbReference type="HOGENOM" id="CLU_2122794_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXG7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="114" mass="11997" checksum="6E079958B91CB1A1" modified="2012-11-28" version="1">MYRLHRPAGAHRQYAARVPTADDDKAVGVASLGPSRLPPSDGGTRGTPSLPRPLAGSGPPAPSPPLPRRGQGEGHGAAQPRRVRALALDQWRTPTPKSRGRAICPAPVIRRPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYL4</accession>
    <name>K1VYL4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-actin capping</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYL4"/>
    <dbReference type="STRING" id="1220162.K1VYL4"/>
    <dbReference type="eggNOG" id="KOG0836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045161_3_0_1"/>
    <dbReference type="InParanoid" id="K1VYL4"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0117">Actin capping</keyword>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="512" mass="54117" checksum="394573DA336F61C8" modified="2012-11-28" version="1">MASWTVRSALAIQAWSLGGGPPRPLGTTPSPITNNDTMAELSPEERIKLAVQFIAQSPPGEVNAVEHEADEAANIYPHVSLLSEAVIAPTTGTQERFVDFEAARSFSFDHVRMTPSDYEPYVLPSKDEAIRKSFAESLSAYTRNHFTEGHWSVACDQYPVATAAVGVLEPAPTPTGSQSGSVSASVPPSRAVSPAVPPIPEGIAVPSDTPADGTSSAASDLPKDAEVDAPGGLKDLDDEMEGVAERLDPTGTAALGETPGKLEPEPTPSVGDADLPKDAEVDQPGALADLDREIAEEVEAEAEAMAEDNAASGAAAGAPAATGAAAVDDEKFTSLDAKLAEVEAADAAGGHEIPGASATPAALKQTPIAQESRAHPSYTLEVVGNRYNPSNFWTGRWRTRWVVDPAVGTVTGTILVDVHYYEQGNVQLSTEHRAAFPVPVETWEDGRDAASQIVGTIAKIEQAYQLELGDVYEEFGEKSFRNLRRALPVTRQKIDWDKVQGYSLGSDLSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZA5</accession>
    <name>K1VZA5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZA5"/>
    <dbReference type="FunCoup" id="K1VZA5">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZA5"/>
    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_5_1_1"/>
    <dbReference type="InParanoid" id="K1VZA5"/>
    <dbReference type="OMA" id="YNTQNVP"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="66" mass="7132" checksum="265EBD8C69310359" modified="2012-11-28" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKKKSPKGRAKKRAQYTRRFVNVTLTPGGKRSMNAQPAGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZB6</accession>
    <name>K1VZB6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000186">
        <property type="protein sequence ID" value="EKD04917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZB6"/>
    <dbReference type="HOGENOM" id="CLU_2387723_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZB6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="94" mass="10122" checksum="FE3E36BBF310AC4D" modified="2012-11-28" version="1">MSRSDEARDGLQAGSLYSGSGPGGVDQAVRTRFLHEPQPPAARFAEAHLQHEAPFTLSTQQRRTDNNGPLVSYYPRNSKRSSASAPGLLHSAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZV5</accession>
    <name>K1VZV5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUMO activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZV5"/>
    <dbReference type="FunCoup" id="K1VZV5">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZV5"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_4_1_1"/>
    <dbReference type="InParanoid" id="K1VZV5"/>
    <dbReference type="OMA" id="YAFFDFT"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="368" mass="39480" checksum="49DE0DFBCA53EB50" modified="2012-11-28" version="1">MSDEVNNAAPATNGQITEAMSRVEADDRMRSSTVLILSLRSVAHETIKNLVLAGIGRLIVMDDGAVTEEDLGSGFLFREEDGAVGKNVSSSNGDYQLTDQRTEAALAQIQSLNPLVSLTAEPTLAPFVGSDGAPGDRAQMAEYLKREGVDVVVACDFARPQLEAINAAVRDADSMFFAAGSYGFYGYIFADLGAKYENVASALIKLQTNYVPLSQALDRSKWQDVETPAGKGGSPFRGLSKANTRQARPDLHIALQSLWDYEAKHGLPSSSAAAVEIQATAEQMLKDLGVNKRTMRSVDEVIITHLAEHATHFFPPTLAILGGLLAQDVLRALSRKDNPITNLLVLDSMGGAASVARWGMDEAVIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0H0</accession>
    <name>K1W0H0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0H0"/>
    <dbReference type="HOGENOM" id="CLU_2063124_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0H0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="119" mass="13057" checksum="A4E751337E775B27" modified="2012-11-28" version="1">MSDRRTSDTPSTIRRSRSTAKPPLVLAEMQRAMSGDKDGTPGFYPDRKLSDNTEDEEQHAPAQRKGSTYKPPLMLQSMFKVSEEGLNLPEEPPQIDPLDASGKPPSPVPEAPSAEGHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0R3</accession>
    <name>K1W0R3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0R3"/>
    <dbReference type="HOGENOM" id="CLU_100326_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0R3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24875" checksum="17447203B8098930" modified="2012-11-28" version="1">MSTQKLPKQDVPKQDVKWTKGDFELVSRDGVKFVVHTYHLQSASRVFRDMIEAGSGAKRIQLDESAKTIRHFLKLATEGSSWFDTDSSEAADYAQVVDLVHFLTKYECEAAIGHLKQCVVAFPVDKITHHATLRMLAGMHLAMPAACAAILRAHPDLFKGLCHVYPDSRNIPDMMPLDVFQLIPLKYLWAIVAAYRHGTGTASVSSRGTCLDLGERFLHYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0S0</accession>
    <name>K1W0S0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0S0"/>
    <dbReference type="HOGENOM" id="CLU_100326_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0S0"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25825" checksum="B4E90C172FB92C96" modified="2012-11-28" version="1">MIGQSAEEITQHPQWKEGDFEIVSSDGVRFCVPSLLLLSISEVFRHMIETGSGIKNIQIDETAATIEMFLEFVSTGKVTFIPKGGPLCYERPLNLVHFVNKHDCEVTLQHLKNYAHVPVTGKDNNYMRMLLAMHLNQPRVVAELIQDRPGMFSWLHPIEHRRPVDRLSSQLSFDIFQRIPHQYLWALTAAGLHLHDQRDPDYANDRAPAERFLWFMRECLFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2T0</accession>
    <name>K1W2T0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytosolic small ribosomal subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000263">
        <property type="protein sequence ID" value="EKD03198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2T0"/>
    <dbReference type="FunCoup" id="K1W2T0">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W2T0"/>
    <dbReference type="eggNOG" id="KOG4592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012622_1_0_1"/>
    <dbReference type="InParanoid" id="K1W2T0"/>
    <dbReference type="OMA" id="YLEHSGH"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="43"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="900" mass="97490" checksum="9365EF6CA508F255" modified="2012-11-28" version="1">MTPSFPVLVLATGDWLVEGHRSESRGHTKQASSPSSVNKPPTMSFFGFDTGLPDDPRAKQGQHSQFASRADQDTFGSFDRAGEEDLAVYNWGEGGLLESGDDFNDETFGDTGDFGNDFQFAAAPEPTQSKPKVASTSSRFGPKAQVDLFAATEDDFYTSQPAKTPKKKNNEPQPLWANASPANAWGAAPIAPPVAGHQPSKILSLEEIEAEMARASIGNKQQPQYAPQQQQQYAPSPQHVPQQYQQPPKHTQPGHQVLSLEEIERQMIGGGPSPGPAQAPQQPPLGQSPHGQQLHGQPPRSQAQNIPPGMHGRSGSAQLSTPPIAGTPPAPGLNGSGYAKQQALLDSMFPDLQQANQQPGQPPAPGQPQHPGTPGFQGPPPGQPQPSPEELARMEELHKRITAKIEGMSKYNNLMGNSDKDFITRIQLSQLATSDPYSSDFYAQVFSALARRAQDAQGNESGPTVVQIAPGMGLGVGGPVGNRFGKMGSATMNRLTTQVKKLVSTTAKRQQAMSSDALAGALGRVRRGANQAAPRPVLAVPKPEHRPAAVAQLNHSSGPTREPLTRKQVMYALEELYDDCLELEQMRREAPPPTDVPRVEAWNQQCAAKVDDLWRKLMVMEPLGVSTPHPFISLINPLKGQRLFPRLLRHLDHQRALTLLTLLIATYPQLEVVARAPPPPVADVSLLTKADREDRARREAQTDSFLHCVIPGVDMLINQCNLGLVAGLLGICTQRMELGAVAATRPGVALFTALLSRAQSLVRGEAPIDPAEREQWTKTFDYFLQTISPHLPDLFPATLAQKAAFGPSAYLLSSEGQARQDRDHGEMERREAEVWGLAAALAVNAPEDQQTNLVAALRDKILHTVQAARDPKTPREKAELKLRNVNMFLHGLGLDASMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4Y0</accession>
    <name>K1W4Y0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4Y0"/>
    <dbReference type="eggNOG" id="ENOG502RB7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1547512_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4Y0"/>
    <dbReference type="OMA" id="AINAADC"/>
    <dbReference type="OrthoDB" id="2568061at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19449" checksum="5FA7258F3232BD28" modified="2012-11-28" version="1">MAKYSPTVTLKGPMNGSLLVFAYTSFIICVVMIHRDKELFHSYPAAVVAQMVCAIVQMLYMFVYFLKSHSKIYSVRNMFIVNGLLMLYCFGASIAITVLGKRHGDGYCPGDTPAAHDCQGVLRGTMGMAWVLWIWNIFWMAIIAMIVSTTNSSWSEPLGNVPVIEKVEEEAPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1W579</accession>
    <name>K1W579_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W579"/>
    <dbReference type="FunCoup" id="K1W579">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W579"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="K1W579"/>
    <dbReference type="OMA" id="ANDDRDM"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="180"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="574" mass="62643" checksum="3133D4FD9AE39357" modified="2012-11-28" version="1">MLASTRTATRALNTARPLLRQSFRGVATQAAGPSRNEYSRRNGRWAFGAAALALPEIKLDSSVETPRDQLPIIHPSEIVKRKTGPEVWVVIDGLVYDMSGFVEGHPGGADIIMHNRSYDVTPLFKPRHPSDQLLPGHLPDSVRVVGRVVGSPEELHEIALPISKAELEEMERVEKARKEMEEKGLGGVINMKRLAENMVSKVCWAYYASAGDDEITKNANGSVYQKVLFRPRVLRKVRDADASTELMGCPSSLPIYIAPAAMAKLGHPDGELNLTRGAGTTGIIQGISSNASCSMDEMLAEREEGQPLFYQLYVNRDRAQAEELVKKINKGKFNAIMLTADAPVGGKRERDLRLKGDFEGPAGGVSIKSDDAKGVSQAMFAGVDPDLNWDDIKWLRGITDIPIMVKGIQTVEDALMAYKAGCDGIVISNHGGRQLDTTRPSLDVLLEIRKHAPQLLRPEFRAPTGLSKEALEHPERLTPPDAPGKQERKFDIFIDGGVTRGTEVVKALCLGANGVGVGRGFLYAQSVAGEEGVEHAVGIFKSEIELTLRLLGANKISDLRPSMVEVTEQPPVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W620</accession>
    <name>K1W620_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W620"/>
    <dbReference type="HOGENOM" id="CLU_1526245_0_0_1"/>
    <dbReference type="InParanoid" id="K1W620"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="176" mass="18635" checksum="4338B308D63DA26E" modified="2012-11-28" version="1">MPPKEEPQPKTLNPEFLANTNFPAAASTYAALMTALIAHSEPSCDCGTPHPPISSSGRIESALAKKWVSLTKAVNVGLSHVPAGTIKSADTLIPSLHKIFGQALEETNVKVCPWRGCDASTVDAAVYAQHLADEHGKATKCEVEDDLGFCGLSLVGYSVHAHLELKHGLIATKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W633</accession>
    <name>K1W633_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W633"/>
    <dbReference type="STRING" id="1220162.K1W633"/>
    <dbReference type="eggNOG" id="ENOG502RY60">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554329_0_0_1"/>
    <dbReference type="InParanoid" id="K1W633"/>
    <dbReference type="OMA" id="QWAQEVH"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052567">
        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="335"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="492" mass="54539" checksum="DC203CC89F1FA195" modified="2012-11-28" version="1">MTLTALDTPYKLTPEQKESFERDGFLHLPDVLSADQVKSLQQWSKEVHDWPSRPGEHMPYDEVRADGTTGLCRTESESNPISPRLPPSMLTEDYANYHDGFNSLFRGERLVGLLSELMGERAILFKEKINYKEPGGSGGFDAHIDSTAYNHAGAVRHQTFLMAVDDMTPENGCLDVVPGSHKVQVPIAADKCIAKDWEAAQTWVPVPMKAGDLLVFGSYLAHRSGPNNSPRPRAAIYATYNGESEGDKHDSYYAHRRRVWPPTKERVPGVDYSEGAMTYAFGSPMAGGKEMIENTIRSQNQKTLKTREETADTVLGVIEAQGDSDYIGESISQLEHALQAAAQAQNEGADDETVVAALLHDIGQFIPHENAKEMMTEGGSLGKMSHEAVGEEYLRKLGFPAKVSELVGSHVVAKRYLTATRPEYLAALSKASQGSLRFQGGPFNPQEVKEFENDPLFKEKVQLRLWDDRAKEVDAKVPDLRSYRDTIIKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W726</accession>
    <name>K1W726_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000192">
        <property type="protein sequence ID" value="EKD04673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W726"/>
    <dbReference type="eggNOG" id="ENOG502SABM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231648_0_0_1"/>
    <dbReference type="InParanoid" id="K1W726"/>
    <dbReference type="OrthoDB" id="2505754at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1742"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1915"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2044"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2129"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1742"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1752"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1915"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1987"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2044"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2063"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2081"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2129"/>
            <end position="2141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2148" mass="223780" checksum="5CE4138696EE4D9A" modified="2012-11-28" version="1">MSDDLETKSNASVALDAPDAADGVAVDAPKKSLDLEAELAQADATDEAEVPVEKVIDADAQEPTDPIPGDKSAAPEVEGEASTEPDQSVDDTAAPAKIDTKVNGVKENAKTIEADEPIAVPAKSPARARAAAAAAAAKDEASKPNGNDVDIAVVNALRAELTSAKEARDAAVSDVTALRTELMSAQEAAQEATKAVAAAQAAEADIGTLRAELLSAKEAKDAAESDVGTLRAELDAAKEAKEAAEARVEALESELQRFKDEHAFTAAAKEAVETQLREQTTKREAAEEKVELLRGQVEAARRTVMQLQKQEQERATRRVSQAPSAIEGSGEDEERKNKRASLYGGVRARPISTQSAATTAASESDAPSTGSGLRELRLGSGHARGSSIAYKGAPPKSPLGEKPIPLPRSPMSQPAESHLDVPAHQRSDSGDIMSGSPSIASSLVHVSTTSEPDSTLQAELQAQKDEAAALRAQVEVLTIKLLESEEARDASETCLRSLREFMAGGDGGDGGDAMQGLKLPPLPTEDDPDDGPPPPEPEPVVAQAEQKPEQTSRWGFRLWRGGEAAPGAENASPSPSVALAAPVVAPLERTISYTPSLPPAVVASPEPMAAAVHTSPIPYSSRSPPTSPSPPLPASVPAEELAPPSPERQAITASPEQQALSPPPPPPEALSAPSAPIEAPAPAPPPPPPRRRAASRAASVASSTADSIINPSEPMPTPPVPTAPLPAVAATPAPPPPPPRAPRRRASKPKTPKKSYTTPLPAPTPLHDATPGNQKSGAFGFMSNWRSSPAQQQEPEPQFDPDQPLNPDGANLDRSLTSFFVRAKRLKKQPPRPLALDNISSLNQARAAEAAAAAAVAAQERGGGHEAAATTNRHVSQASIGNLNTASSIVSSTETAPVVHDFDEVPLSKAATAAFRPMVRTPPRSPIHPARSLSPVQQIAPPRSPSPVVVPRPESPVAVARSPSPVHIERPSAPTPLAARSPSPVEVERPSAPTPLAARSPSPVMVSPPPVASSIITRSPSPVARPLSPGLRSPSPRPRSPTPPPFEETIPSAAPERADPVRTEPECSRQTPPRDAPSSPGADYETIKDREALVSSVPGSAVQSPFDASDTPVLPTPLPYPERPASKSEERRQPEVQTEPQVVSKPVVAAPESAPAPAPAPETPAMTQTPEMAAPAGFTPSQLPTPKQGPTARAPAPIVVKKLSRNSPASPELLLSPQSPKPSPKPAVYSPTSPSGSIMDRPRPRANRGPSYEYGAAITRVKSPLSPLSPTASSSGFSSPVRGGFSSPVRAEYNTERTPRFLGFDTSIPVDERGARGAPSPSLSVERSPRLDPTPSSELNSLEAPLRSATYDAPSPAPSSTESVVHRPRPRRGSSLSSASTPVVVSRVTPSPVHQAPRMDSVYSASGSARTSSPVTSPDVSTKPLRTRNDDDDGLASIGKLLAPGAINQSNSSLSNSSGAGPDEEEYLEDDSGRTPSPPEEPVTRRTPSSGPVRPPRRVSLYSSDAPPPITAGPASAPVQDRPIAPVAAAPPSPAQSVTPIMMHSHSRNLSAANFVDPAMLAHGAAWAPLSPRRPIDAVPASPLAGALTPASPSTASVIPGLSASNSPSTANSFSRGAYNVGDHLPTPAHLMRPSNVPGNHDMLSVPWARRAPSISSINSVSDEGHGLSRIGMNLQALNLSPVPGNSMLNADMNVNTAGLTRRETKKLSRERRASFGQERAWNDNPRTDFMALAHAYGLNKPPEMQQQHQPPMQPQQVPPTPPGVSRGVRLSDDGPTPLPSVAATPTRGVRLSDDGPIPPANVTTRGVRLTDNPVPTIQMRPPDNPIPVPPRSALRPASQAISREDSVGSFERLRYSTASTETEEHSNYVLPPRMRALGPPIPASALEQPLPIRTLGPPMPLAPPMEIPIPPRGAYDQGPASAPAIPPSPSQQGAPKGVRLVDPGNGHVPRRGSESSSVKPVVRPRRPSETGAILPRVAPGPGPGFTSGTQAQTGFGFNRPPAVAPLDLSAPVAPFRRAEDHDLAKAPPSPTRHTMTLNALLGNSAQNSPVNSAFSSLTGSRSPPPVPSVPTLPPASVPQQEEKMEVVQDTPKRNEGPAPVRPMRSARRTQQGSISGFSAVSAVSAVSAVSQASNVSGNSARSRGGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8T3</accession>
    <name>K1W8T3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8T3"/>
    <dbReference type="HOGENOM" id="CLU_083702_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8T3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29604" checksum="1437D5FA08A66CEF" modified="2012-11-28" version="1">MTTTFNPDDYPHIIEAVVWSSDWPTLLKLRLVSSRMKRFVDPLLCKDLLELSTDSTGDLTVSAWIPWLYDHPLCIPYFHPSGNEFIQRAAMNRAKRIRVICERATFRLNELLQWISPEAEVVFLHSPAAVFDVDTRIPVCAGLTIEAQIDPHCACQDESRGKLTHQSKAVAIHFVSGGGEERSGLPRCVVIDGAVNLGVQHLDLVDFFSDIRPMLCGDADIDTHPELRVRVKKRWGSESERARLKLAERFSVEESRVYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9T9</accession>
    <name>K1W9T9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9T9"/>
    <dbReference type="STRING" id="1220162.K1W9T9"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363768_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9T9"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="82673" checksum="4BAEE2A600E96FBD" modified="2012-11-28" version="1">MLRTPAALDVDPDVRRSLDSLPELRHPSLASLTAPASVSTDNLISPAAANKVTEALTERLTASIVDAYERHLKFTPEGCRWVVEGRAAFTKTVAFFVAAGKAVEFVLPAFPCKSSNLNKVSGALPDKGEELALRTLKLFSEDVTSFYSPGVLVRVVSDGHVFSDLVGTDDAAVDEYNAALKDMAAGIDARVLFAGLDELIAHISDTPPGEIPATGPMATKHTPEADTARATLLQLYGQPPTTIDERLANDKALLGLCRGFSRFVFEDTLQHPSMKTMSQSKRKRVAWSTAKLMILRNEAYSRLVEVCFPTAFPISLVHPSFRSGLGAPVEAQLFHIPTPWHNVVLQLPNGGYASSAPLRRERAHTFVLCFFIAAPGMGHVIPLLHLAHWAAQSGIKATFLASDVPLKRAPSLMHPNLTLVALPSTGVTYEDYAQGPHAVMPLYQQMIGPASAELERLAAEGATAVVASPFIFFGSPVAKRLGMHWTTLVDVSPIGAAVTLRVAAAAVGQEPEEQLCPDGLDVPGYMRVGTEDVIAVFGEKGLTPSGPTVWLASGFAQLVQESDAMLANAIPGLDDLSEAELGSRIGPLFLHSPSDLPADIASFLDKQQPRSVVYIAFGTLSVRDDALLEQIHNVLEEIGVPFIWITNAELDPLPNGIVQRWLPQAAVLQHPSIGLFYSHGGWNSVLEAVAGGVPMLLKPSHAEQWLNARVVEEKYGTGRKGCPESIKHWARGGWAKETANAAVLAEKVTQAQAQSQANWDKWVEAAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAN4</accession>
    <name>K1WAN4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAN4"/>
    <dbReference type="eggNOG" id="ENOG502RB87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468663_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAN4"/>
    <dbReference type="OMA" id="SSINWRN"/>
    <dbReference type="OrthoDB" id="2596986at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="582" mass="61747" checksum="C31D6EDAB539065E" modified="2012-11-28" version="1">MGSPLSSPGKPPSQVLRDQRRAAPDVSPVATRMRASSPDILVPSSDDPDSSCSDAAVTSTPYSSKYRHSSNPGSGEDPFRTPQHSDSSPDNSLSTPSTAPNSAASASVELFLGPQPLSYIHLRNRILNGEEYNPSPLRPKNVDGHAEVPPLMTVASNSNVIERPPQVTLVPSEKVAPDANAPQLSKWRQEQLKKVKPIRPVAGARERPIPLLHGPLSLPYARNPSGVDATVADQSSYMSHVFGLRVVNSPEDKGGNSNSRVASESAGRSNNSGGGYASSSTHHHDKSNPFSHPNPKQRPMVVRDYNQVIGIKKDVTQEAPDVNHLKMSAYLAQAVDARTQLGLGKPAAPVPSPPDNKGRIPSDSFLPQYPGNQGADNETTTLTLVDPLTQQFYTVKVPKSSVADPVIDLSSHDKIHTSTPYSGKADSSINWRNKGSRSNQGTPNRSTTSAQSAVSSLVTTKDAGTSPQVLTLEHLYEKFANKKEDMSTYSSPKSSLSKSSTPASVLKALSALNDNSGRKVHVSEAESSAANTSKSSPTKKKRSTSGKSRSAATKTDLVSTGASPQKVSAGRRSKRTAKSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB38</accession>
    <name>K1WB38_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_06844</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB38"/>
    <dbReference type="FunCoup" id="K1WB38">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WB38"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_4_0_1"/>
    <dbReference type="InParanoid" id="K1WB38"/>
    <dbReference type="OMA" id="QYMQMNG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="946"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC98873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110110" checksum="2E8B124C56A000AE" modified="2012-11-28" version="1">MDPFTTFEGASQYGVDQDDTTSMYSATPSNLTEQIIVPQRTTGLERGIDEISLTSRPVNNFGEEYDRDDEPPLGHGVEHACSPQSVVKWFCNSRGNTSASHIVSHLVKAKHKEVVLHKDSPLGDTILECYNCTNKNVFMLGFIAAKNEAVVVILCRHPCASTTTSRDINWDPSEWSAIIHDRSFLSWLVKVPSEAEQLRARQISMAQIAKLEEMWRDNPNAKLEDAEAQDAYQYQNILGPLVKIEADYDKRMKESQGESDISVRWDMGLNQKRTAWFTMPKLESGEVRLAVGDELRLKLVGASMKGWANMGNSSDNLWEGVGSVIKVPDNNVPTDCREGFAVDFVWKATSFDRMQQAMKTFAIDEKSVSGYILLGHEVDPQVLRTQMPKRFTAPGLPELNHSQMAAVKAVLQKPLSLIQGPPGTGKTVTSASIVYHLSKMNPGQVLVCAPSNVAVDHLAEKIHMTGLKVVRLTAKSREAVDSPVSYLTLHEQVAKNDTRRELQKLIQLRNELGELSQSDERKYKSLVRACEKDILNAADVICTTCVGAGDPRLAKFKFRTVLVDEATQAAEPEAMIPLVMGCKQAVLVGDHQQLGPVIMNKKAARAGLSQSLFERLVILGNRPIRLQVQYRMHPCLSEFPSNMFYEGTLQNGVTAPERLRKNVDFPWPVADTPMMFHQNTGTEEISSSGTSFVNRTEAANVEKMVTKFFKSGVLPSQIGVITPYEGQRSFIVSYMQLHGALKKDLYKEVEVASVDAFQGREKDYIILSCVRSNEHQGIGFLNDPRRLNVALTRAKYGVVILGNPKVLSKPSMMQFSKPRKTLSRAMESFRRFEPPANDYAEKNARGGPAPSRFDPAYYRTHDAISYVPADAQSVVSQALTQSFPLAAHPYPGAGPGGRKSTYTGYASSVISQQPADGAPDPLGTGHALAPMSSRASSIAYSQFDRLPPGPALDKKPAGLGQRRLSIGSITPSDAVSSYGYKAGDDDTQSIAPSQAGVTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBC2</accession>
    <name>K1WBC2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell cycle control protein cwf19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBC2"/>
    <dbReference type="FunCoup" id="K1WBC2">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WBC2"/>
    <dbReference type="eggNOG" id="KOG2477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015540_2_1_1"/>
    <dbReference type="InParanoid" id="K1WBC2"/>
    <dbReference type="OMA" id="MVEFASH"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="327"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="442"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="62649" checksum="F2B22E7BC224F0A5" modified="2012-11-28" version="1">MKLRRLNEQAEEQGVPVESIALERYASMEEYEQALEEKRFLDDRDSRRRSRTASKSGTPSRATPSRATPEPMRRMVFNDDSRPGSRQGFRRPGESPAPGGAGSSGAAGASRVDALKRQESYGTPAKTPIPSVFTPQGITSATVMSTEELNRLQAKVLRAKLMDEPGAEELEKQYEKEVLKSQAALEGRKINDAVEEEGGKVVVQTAVLPTLDGQGRLYDVGLGKEEAPPHPNRRKRNKDPKSRDKEGNIIRYNADDDDMTLDEMVRQEKFGGGASDQKNLDAEMAAQIARDGRFQADLEYMDENSERLARKRMRTDAMKRAFAINADPPRLPETAIVALGKRTYLSCTVYEELTPGHCLIVPIQHALSTLELDDDDWDEIRNFMKCLMRMFAEKNQGVVFFETVLSFRQQRHTVIECVPVPADVFADLPAYFRESLMQVESEWSQHKKVIDFSQRPFRRAMVPNLPYFMVQWDYKGEKGYGHVIEGVDMATEEGDDGDRGGGKFPPYFAAEVIGNLIGAEPRRWMRPARVDRALNKDRARELGTRFQPYNWTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD12</accession>
    <name>K1WD12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD12"/>
    <dbReference type="STRING" id="1220162.K1WD12"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="InParanoid" id="K1WD12"/>
    <dbReference type="OMA" id="CDIRGVF"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="34826" checksum="5EE1B970F4D877BB" modified="2012-11-28" version="1">MKALQITTHGHPQVQKVQVLVDVYAAGLNFFDILQAQNKYQNQPPLPFTLGAEFAGRIAKDSPIPAGCNFKPGDRVFGSGQGSYAEQIAIDYFRLVPMPSNISFEQAAGIYVTIPTSYEGLVGRANTQPGEWVLVHAAAGGVGIAAVQVAKALGARVIAAAGSEEKRQIAKKCGADYAMDYNAPGWQDEVKKITDGHGVDVVYDPVGLLVPSLKCIAWNGRLIVVGFAAGTIEKIPANLVLLKNVSIVGLHWGATALKDPKRYFEVIDEVMKMISSGRLIPQVYDPVYEGLEQVTTGLKDLEDRKTWGKAVVRVRHDDKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDK1</accession>
    <name>K1WDK1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDK1"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299351_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDK1"/>
    <dbReference type="OrthoDB" id="2587749at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1216" mass="131206" checksum="3A02D02B83CBF404" modified="2012-11-28" version="1">MVFFPPREIVAALITPGVTMDYAADIIEEHVLHRRAKGDSLIDVANTMNQIEKRVPRAAPAVRQAQYITNIPPPSELTPPPTPAGHPASASTTTLLRYLTSEPTPSIQRAREAILEYVLNREARLREKKPGRGGKGTLGRDGFEEIAASLAEIEDGLRGTGILAEKGVVRDHFVPDDELDGARQLGLALVLSLRMLLSYFTLPDLARQILALPPSDAERTLVQHIRRRVAGEGRYAVARELEYVESLTLGRRPALRPAFRSARARTLLPTQVLYPIALPAPSKSSCIKLLTSFIKDIELGGPGAAIAYTGNGVNVPLGVERNGFGAKKRSPRMSDTPLAPSPVTSPLRSMAQLPKDHNPIEAYTLELLSEYITREKREYMLKYRWAKSGREQLGKDLGDIEAAVCLVGKNTASKHAPTLLPIFLELRRTFALPVSPLPRPIVDPYYDVLPERPDPDSIPLREPTVSSITASLYVNPRLDDAAALNVIEELLESEREKGVNADVSEEKTISWLNGQIDQIEKRTVFEHARYLAAHPRVMADADAQSAFPPKKREEEEPPRPDSRSLAHRRAKSTANPLTGNEEFGSNGDMAPPRGLHRTHSRSASMPLRVSTSSGYSSRSSKQSSYDISSPSPVVAVASPRDEPPPLEASPADNVEKIASDGDSDSADSEFARKVAPFPQVTTPASPQSPIAAIRTDIPDTKPVLTLDFDSPTKTTDGGWWDVLTSPARLPSEHTTTPMKMPTGESQPAVSEFGTPIKMLDFDRTNTVTESPRDRNEPDARPMSDQSTYAPLTGAHLEALRKLDPSAVPPVSQPSAEATPSSPIDISAPGMLLNLGSTGRRSGASTPTSGTPITPTFSRSSGGLGHSAPRSPTLPTPTLDQLISEEDDLARGPPMFASVNRPKPAYAQHGKTMSQGSTMSQVSVGSSQHGKTMSQGSNGPPSSLRMLNSVGSPDAYAASGPHRRTSSGAPHPSTLPGVQSQTLPSRRGSGARPPPVPGSRPILADAALQTRLWCPPSAGTRYDRPAKLPFFVAQLANAVAHCCRHSAHVGGQHARVAREPAAVWLVQHAAAREPSEPLEPGPHDVAKAVSGTAARDSHKPMEREYTYQKREYQVVPPLQPKHLAQQPAQPAPYSHQPASPAHHQPAHHSQHSHHALPPQPKPLQPPQPAQRPLQPINPVPDANAAPMRNGRGSQVDNSPAKWNKAMVAGIMGPPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDL7</accession>
    <name>K1WDL7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDL7"/>
    <dbReference type="HOGENOM" id="CLU_712101_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDL7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="42403" checksum="0F406DFC1E8C92B7" modified="2012-11-28" version="1">MKAKPVKPLRSSKSTPPPPVESRKITLLSSDGYPFEVHPIKLMGVPSLYKAVEGRGTESRVLRLTDAVLEHSEVIGLFVELLVHRQCMELKGNSLPDSWGGVQKYVHLVRFLDNAGHCEDLIALFCYQLGKAVEGKKLAAVWGALLGGLAKDVDLMVISLKAGDVNDTWTTEEDVLVTDGLTTAEGWALVKADAASGGDRILLGANRLDPSSWSKEMRGLICKDYLLALYSGWTKVEPEVHLLEGYVAMSPTEVGSDDGRDSPSPSLFVRTSSYRKRNLLSRGGAAYFSRRLASLSIGTARKADTEQELSDLSRSSGTDRTSSETDPMVAVWKQYAEEVKGALAELNRSAPVAVLHHPVPVLAGSAKDRMRHILAYGVNMRSRMNEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGV0</accession>
    <name>K1WGV0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FUN34 transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000336">
        <property type="protein sequence ID" value="EKD00654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGV0"/>
    <dbReference type="STRING" id="1220162.K1WGV0"/>
    <dbReference type="eggNOG" id="ENOG502QUJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_1_1_1"/>
    <dbReference type="InParanoid" id="K1WGV0"/>
    <dbReference type="OMA" id="TWRINVG"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="209" mass="22785" checksum="F8107BE93FA53A1A" modified="2012-11-28" version="1">MTQALTDDFQYAPPPKLANPGPLGYFSLGTTTLLVGLMIYGVQGVQSLAMLIGQVAAVGGLGMLISGFWHYQQGSNFGTAAFGMYGLFYISLAIVLYPIAGASAGYPDAADYNTALGLYLLVWFLLSLVMWPVTWRINVGLTVLFTFVWLYFLFLAVGFMISHKQVINTGAAFGMCVGAWSYILGMEHLYAEDDCFIKIPNPSLAKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHI4</accession>
    <name>K1WHI4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHI4"/>
    <dbReference type="HOGENOM" id="CLU_058505_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHI4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="396" mass="45184" checksum="14305CBC9EAC4283" modified="2012-11-28" version="1">MPRSSTVAGKNVCTAAHNPHIHTIQQESTTPLAPRLRLSTPFRTCSFLPVCRLSHRHQGGIALTAQQAKHWIPGALQPTHLLNCPDFNSTPATSPRQPAISMALPWHLSIDPEMEPRDYDHWPKHPEWRHRYDFLVATPPPLATTCYSSAVTYRASVLPLVRYHFEAFHWGHDGSLITLRADIDGALHNALSLFDIVVDAYLTHGLICNSSWWTLQNEGFKEPFFEVIYDLRSYLRVIHAIAVLFSREVHTLSSLESAHDVPSHWASHPHDVTLSPDLLDNEKMPPLLRQADDYVFRLCRLFTVRPSFTEALDQTLARAREQADSVSEWARKEVGTTQHLSDYFVGFKQRRSNCIQIAFPMAKKNLMDFLDRPLEPERVIKFWPFAEQPALPAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHM7</accession>
    <name>K1WHM7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHM7"/>
    <dbReference type="HOGENOM" id="CLU_1373074_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHM7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854430" evidence="2">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="199" mass="21612" checksum="D021F75A2DCDE5EE" modified="2012-11-28" version="1">MPPPTVLAHWLLALLALLAQTSLCAQPSSPPSFSLAMLPPELPPPPSRRRPSPPRLSSPSPSTGIARTHAPSTVSPAHTHTHRQPASARTLCPFGSPLTTTTALNPLDSIPRHSFLAPTLSLLLHLSHPLQLSPSPSLPLQTEQRLTATAALLTVPSSYSDRRTRHYDYPPTFFLRNKSPHTKPTLPCLPEPRPMSRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJ39</accession>
    <name>K1WJ39_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJ39"/>
    <dbReference type="eggNOG" id="ENOG502STY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048752_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJ39"/>
    <dbReference type="OMA" id="ERYIRIW"/>
    <dbReference type="OrthoDB" id="2581980at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52609" checksum="AE6D28C8E40DC20C" modified="2012-11-28" version="1">MTLKSGYINPDPIANPTVLGKQEVPIAPLSCWAVGVIGSVLTFPTQLDQERLQKAVAKAASYWPVVAGRYVKATVPGTEFASPIPFDTQSVDAEYPYADRAVVQDDLGEYVTPLRDDFFVAGADAPLVTVRFTTLKTGSALGVNWSHVLGDAAAFSRFLEDVSIFYNLPYTDLESDEVPTFQPHVRLPPATDAIKEQFKIPILTRLPIGDVFKGYTDSVAQSQRFTVNLTPDDVAHIAAVRLPGDKVTDNDLVCAWWCSVLERAGQPLDWVVQTMNGEPAFPRNLPTLSANVAQQRQIFIPPRGTIKGAQSKPGTRVLQIARAIRGGMHALQNDPELTLGWLSNAAYEIGTAAHENTSFCLVPEASGVVLNSNWRYDWAVKFGQPSAAYHTGGSFPRILRVFRANPVEGQSEEDRAVELAFRVPSGPAVEAVQKVIDDERARWKAEGPVHEHEDEDEEPEVKSFSMHSTVAREPWGGYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJB4</accession>
    <name>K1WJB4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJB4"/>
    <dbReference type="STRING" id="1220162.K1WJB4"/>
    <dbReference type="eggNOG" id="ENOG502S71P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075896_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJB4"/>
    <dbReference type="OMA" id="IGHFNRR"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="30267" checksum="992F766A6EFBFB57" modified="2012-11-28" version="1">MKDDTPKGALRILNAAKVQAAFRKQGRVTSEDTGEHTLKRKRGEEKKAAKSSDDSKANEPAKIRTEADKEAAKAEKAAKASGEEGGKKKAGKPEIPKIGPNETLGEYNRRVEALMRGSVNKAIKSAEALKGQQIQALKAEKAARRAAAQAGLPPPKPGSSFSSNPLPAGAAGKKEPSPSPEPEERTFAEAPQRRRLNDIALAPPQLPKMRQAKKTPSEIGSKIPLNAGQKRIMEEERERVIKMYRDMKARKEQEKAVEKEEKEAEKRKKKKARKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WK57</accession>
    <name>K1WK57_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WK57"/>
    <dbReference type="HOGENOM" id="CLU_2039711_0_0_1"/>
    <dbReference type="InParanoid" id="K1WK57"/>
    <dbReference type="OrthoDB" id="10601752at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13215" checksum="30A34CE891C33FFF" modified="2012-11-28" version="1">MPPKKRSSLSTDDDEKPDLSDSAHMTSSDEADPSFSPKAKKPRGAPASPGKSDSKPDKFSQKGKGRPWTSAEYVQLFQRVEDLGKKAAFEGFPGRTKNQAYQAWRNVVAPACIKALETKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKB8</accession>
    <name>K1WKB8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKB8"/>
    <dbReference type="FunCoup" id="K1WKB8">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WKB8"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="InParanoid" id="K1WKB8"/>
    <dbReference type="OMA" id="KMYIEEG"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="221"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="320" mass="33548" checksum="FEB367A308BE03C2" modified="2012-11-28" version="1">MVSQVKGFYAASVSEKKAPTGADLYARFALAGALGCAITHGALTPVDVVKTRIQLEPEVYNKGMINAFRQIVKNEGAGALLTGLGPTVAGYAVQGALKFGGYEFWKKQAIDYLGVKKASEHRQAVYLGASGIAEFFADIALCPLEATRIRLVSQPSFANGLASGFLRIAREEGIGGFYAGFGPILFKQVPYTMAKFAVFEVASEKILQGLGRTKASLTQGEQTGLNLGAGLIAGMAAAVISQPADTLLSKINKTKGAPGQSTTSRLIEMSKQLGVKGLFTGMGARLVMIGTLTAGQFLIYGDIKRMLNATGGVEIAAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQY3</accession>
    <name>K1WQY3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Water channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQY3"/>
    <dbReference type="STRING" id="1220162.K1WQY3"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_1_4_1"/>
    <dbReference type="InParanoid" id="K1WQY3"/>
    <dbReference type="OMA" id="HHTLRTE"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="241" mass="25956" checksum="8D4101E6C3558B2F" modified="2012-11-28" version="1">MLTGSFFIAVMFGASLGTNVWCFFRISGGLFNPAVTTAFVIVGAITPVRGVLLFITQLLGGLAGAALADVLTPGPLLAETTLGGGASVSRGFFIEFFMTFMLVTSILLLAGFKNRATFIAPLGIGLSFFICEMFSVNYTGGSLNPARSLGPAATNHNFPSYHWIYWIAPLCGAALAAVFFLILKYLKYETNLGPDCDDDGFTYGYQLDMRDRMERVENHLANLSTHYVPAGRQTEGSKVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSK5</accession>
    <name>K1WSK5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSK5"/>
    <dbReference type="STRING" id="1220162.K1WSK5"/>
    <dbReference type="eggNOG" id="ENOG502RDER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1361286_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSK5"/>
    <dbReference type="OMA" id="AGWHELY"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="201" mass="22404" checksum="286DBC820AFA22A0" modified="2012-11-28" version="1">MGMTVASELRVTAHSLLSPSEPTVEDTAESEAGKLSAKKTEQKRPGEEPMPPALHISLSHPLPLRRPLSQTFPGLVSRILRDMPAFSVGLAWPPKVYNNAPKNGPKRAFLALRTSAGTRELGTLLEKVDGLLRREHLPTYHENPEFHTSFAWWLDDGKKLDLGLLEKHKEEVMALLKSGWRVDHVCVKVAKTITRIPLRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUT4</accession>
    <name>K1WUT4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine protein phosphatase 5 phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUT4"/>
    <dbReference type="STRING" id="1220162.K1WUT4"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399013_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUT4"/>
    <dbReference type="OMA" id="EDEHAAC"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="640" mass="70601" checksum="84768F2D41D29947" modified="2012-11-28" version="1">MPPLMRFPAPALPQLFSPGLDMESLAAANSPYRQPAPPPQLPMLQLPGRHQEPLWYDPNDDKQAGPSCPHKSRWPACGDHVSAEKRLAAFTDDEVEQISQDIGLIVRREFDSWVEACWTEAFHHVFTRTIPTFLISLILAGASPTLMRKHIVHGGPELDRIFMSDMLDNLYAELERRLSGRLDVGVRGEVADAAPLIGAGGLGAQPPAVPPGLPRDGVCTYDLGPSHGRPLEEDEHAACLCQLTTCLSCLSEAALKRKTPVGLLPYELRDSPMAIRWQGRIETQAQARSRACPEPPERNPSAPLPKGVGFQRVTRSPASNPASRPQIFPHPQMTDVLAVEEHLRWRLKEMGAVDPAVEARYGPSTNAPAALEGLGSALKPLDEDGKSDANGKNGRKMTTGRSKARFNKSVKAPPKAKTPAKKVYLPAEWAEMDPNVRNMAVVLTFRHFVKAASTSSPFSYAGYTKDVAALESAHPIAMYRRLTEPSARKRERGATLGRAWAECMDKWMEELGMREKALGNVHVNNGNYVTAALAYTRAISLDGKKTVYYTNRVVALNAMGEHEAAEADCTRILGKDPKNSKAYYQRALARKGLGKWREAEQDLNMVIKLQPNDSARKLLDTVRAEVKKLPKLRHEDVLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWZ5</accession>
    <name>K1WWZ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWZ5"/>
    <dbReference type="HOGENOM" id="CLU_539902_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWZ5"/>
    <dbReference type="OrthoDB" id="10473444at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="505" mass="52264" checksum="B1979A7898E3816F" modified="2012-11-28" version="1">MVPDTIHLHPEFTGTSADITLLAGHTGFRVNRAMLAMASPVFARMVRDAALSANIVETGDEPAELYAFLKLMRIGPSRVGGGGSGSGTGAAAVGAAGTGSVETTSGRKAGGLAESTGSTGAARAASTVAEEVTKTEGPIRPARSELRRLSPVAEESDGVSSKSSASSSGHKREGSDPKSTRSKPLSDSHSANTPAKPRILVSRPGTGVKALDRALKDAQAKAQGAQGTGVKKKKSRVRFQDPNPKNVPPVPPVPVSCPTSPGAKLAKLPPSHPFGSAVPRSPTSPVSLSADMVRSRSGSSSSGSGSSGIEVTVEPPSPPSISVSLPTPTPSPPKPNTPLPTVPTGQGQPAAPAAPAAPAAFEPSIPQLLQIHALTSKYPGFYTHAVLDFHVELNAPSIVGSLGSSPSQLELFRLLELTHRLRSSKLWSLVLGKLASEGWWRARLDPWSFGEVEVGVLGQDLFSVLAILAAVHVDKVCITYDEGELKLGEQWLMSRGPGLHRYLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1UZZ3</accession>
    <name>K1UZZ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1UZZ3"/>
    <dbReference type="HOGENOM" id="CLU_065431_0_0_1"/>
    <dbReference type="InParanoid" id="K1UZZ3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="362" mass="40999" checksum="D8360680871C3C8D" modified="2012-11-28" version="1">MRQRLQVVEGENERALGTLCPDRVRGRQRSRTKSKPGLSCDLGHPVECWKLKAEWRLAKHVSVFRALNCSTGVYEYVFKSRDFNDAHGSVELWRNTRSGEHDNCQMSLSEIFRCATALDIYELPVNQFELDGDVEIWPLTFARIFSDREEQAPLDWIEERELYIKYSNPCELVCFVQVQDGHFYGSDVPTHSVRELTLNVVCHSNPATIPAPMCLARAMMFMGSVPSSTDVEQFTIILHDARETRAMEPFLGDCACCPLEEEEYLDHLDDDLSLSRCGCLGGLQLSCLGLTAKVKSITIVGAASFVPEADWPSYQQQLGDGVDEAMEYFGDALRLKGLMRFCSNDEYKSEVGEDRYQSLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V018</accession>
    <name>K1V018_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V018"/>
    <dbReference type="HOGENOM" id="CLU_790337_0_0_1"/>
    <dbReference type="InParanoid" id="K1V018"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40720" checksum="89CE5981B789B81C" modified="2012-11-28" version="1">MVALDDRFYPHIVDQIWSYMNYPDYLIGRRVSRSWKRRADHRLRTEENLARHISISVSRVGGSNGKAVTNGLPEYVGKGKGKAKEVEVEIVADDSGDGVDMIEVRSRDVFAPHRSVILCYEPLSFWSFAGNPELERHWSLLFAKTELVDLMDVMSFRDGKDYGRLPSMIGPFATLRWHHGGRGVGPLLTDHSTQVVFGAVDAARGLTVPRLRISTAGLAEVVINVDCFTNPLKDTACLDSLNSVLALPDFIKEWSMITMILNNKIPDRDKAKDSRPGYTSVGLMINFIETARELELTVRVVGVERFLDDPDLWDTLLFRVREQMEDPEERNDLVVFWTHEDYKMQYGIEQYLTHTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0G6</accession>
    <name>K1V0G6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0G6"/>
    <dbReference type="STRING" id="1220162.K1V0G6"/>
    <dbReference type="eggNOG" id="ENOG502S8P6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313562_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0G6"/>
    <dbReference type="OrthoDB" id="2526154at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="934" mass="98005" checksum="7BB4AE11598A118F" modified="2012-11-28" version="1">MTSSIASGSNAPVIVDDLVAWPPPPSIARFGGSGVLRQTRLSLINPLNSPPSSSSAGSVPSATFPGASPLTGYANSKPPPTTPKSPTRLGTSWAEEDEIALMSPTKASNRPAYPPPNKPLSPQHLGRIAQSFGIVTPTLPSASSTRTHTRSPTQQSTYSVGSMGHTTRHTPAPSLSQQVVAVVPPTSLMPPDEGDKERAKKWRRGRLLPLQPTLGSMLVVIAREFGLPSTTGLSVYLGPAGGYAESVSAADDGGPLITQDSWATLFGAGAVGMGVADSPRSGSIKRFPRASTSPLTRVDEDGHVRDKSVSSQPDMARSSLSSSSSYNSPRTPASVSLPSFGTIEFDVAPDAPWLADYRAGKRATEAAGGIRDLTLVQRLNDSRPKFLKDMADERERARAASLAAQAAALEAARLSAAQRETVVKEQRVRRASELERQRTRTMSQDSTGPPTRLSLRSPAPTPPRPARSSARPPSTIEAPESSSGHSAEPEPILEELPEPREAEETEELKLLGPISIEPFDADRTSCMVMAHQLNHLEKMMKTLSPQDLRFTVTPGSPRPEMPRSPGSAASLSPALSPALSPASAEGGEGLRPTSTFSNEFGSLPPRGSSRLPYLQPENRSSLSASTDSASPLPSPRRASDEGGDRSSIATLNGQPRVRSTGPPPRPARPPTPDLSTPDLVEHVLPAQYVDHIKSPVSPVPRPASMSLKGLKRQLSMRPESGADFGFTPRDTASVGRAAGRQTTVYGQYNDVNAQGSQRRTRRESEFGSSRISRLFGKKPSIDETRRMTIVHLSSPVGTAPPTQLSHSRQPSQQQQYGSFNSVLPGTAPANSGLGLTNGSAGGGSGGGSGGGHALASSAGGFSGQGVGLTGAMTGLAGIPHARKPSRDAPPPPLQLRRGTPSDGTLSPTSPRSNYTRRKPVPGGGSRGSMDVLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3K0</accession>
    <name>K1V3K0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3K0"/>
    <dbReference type="HOGENOM" id="CLU_872058_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3K0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="319" mass="35386" checksum="0BA2A03C5075213B" modified="2012-11-28" version="1">MQGEIRAIREDSTARVIRAEQYFDALRAEGSWDNADLAWMQEAHINCLDLERRLDEADALAAHEEVAAQQPVQFEQMAQVNADTEAVAETGGQNQPRSEGSISVSAYDIFADPSESEESEDDGWLTDVSTESSDRDGDNLRSFYDGTEEELEPLVSQTPEGECIHPPMLISDAEVQPTPYPPGGWVAYTFEEQAYDSNVAQDHQQAQYATQHAAQNAPQPVWGVPYAYPVHFLGPVVPPFMPLNPFSSMPLLPVAVTIAPAQYAPFQSAPYQYQAAPHQPAPELTADQIHNLTYTPPRRRSSNQQENTQDDSDAWCYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1V425</accession>
    <name>K1V425_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V425"/>
    <dbReference type="STRING" id="1220162.K1V425"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_584204_0_0_1"/>
    <dbReference type="InParanoid" id="K1V425"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="208"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="468" mass="50774" checksum="E9E076C30E2E0899" modified="2012-11-28" version="1">MSPLPRPEQFQSTAVQFDEVALSDTEEPFEDRGHHGRRSHESTFDHIVDGIARRLSVEAAAGAANLYRPRTESNTSRPGSFSSIHSHRRSRSSQHRGSRQSCQSPHDQSSQQNRVRWHSHVHDRSSERPRPGDQLAVSEDQGGHLQRIDSEKTLARSDSDLSSKGSLAERKGSSDVVGNVDCLPRPPVSDDLESYVSTLYSDAGIPELSKTRKIILGIVSMSSNSVILTIPRMSRDLGVSQLRAQWVASSYTLSYGCSLLISGRLADIFGRRWLFLGGMLTAVIFTFLSGAVKIFIPLCVIRAIVGVGLAVATPAAFGIVGVNFRDQKSRTIAYGSMSMGNPVGASVAMIVGGAMASAGGSGWEYLYYVLGGIALVPLVLGFFVIPKDPQPEGPVDKRVDWFGGFLITAALCFFTFSITEYCHIHIILATHAQPVPPLTLSRSVDCNLSPAGLIPRLPPSLFVTRAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5Q9</accession>
    <name>K1V5Q9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5Q9"/>
    <dbReference type="HOGENOM" id="CLU_1628226_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5Q9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="163" mass="18512" checksum="989614006F3AA123" modified="2012-11-28" version="1">METLAAVAKEEPITPGTHSSYPHELGAEWHDLTTAPLACNPTRSQLKHIVPRISRATHLLISPRGNFRLARSGTARRLDRLADVAIPMVLTSVNTDPRNKRRRDRDRTPRGRRAHQVIELRLPVHTARPDRGTDSQALNTFVVSLENDEDDQQRRSVRLNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5S8</accession>
    <name>K1V5S8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5S8"/>
    <dbReference type="STRING" id="1220162.K1V5S8"/>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310610_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5S8"/>
    <dbReference type="OMA" id="FEWLETI"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="593"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="831"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="873" mass="95354" checksum="1517015952DF0943" modified="2012-11-28" version="1">MAAAERVFSGEFDDIASDDEGDPQTPDSTSQGDHSEGDVSMLSDGDEDVMSENDNEGFELDDFMDEDGAAACLDPYANVFFSKERTETLLEPALKSIFAQIPIPNGEDNAGQTMRVRVLSRGEWMSGCPEGNEQSFLFQLYEKLTSGKFACPNSCGHEFDRAPEDFFALLPDFPAYVSHLERHIQRKCPKCNIKVCSACEDPVREPSPEKGGSPDGKESKALFHCPTIQGAILGVALHMIEQEFGSQLRIAKPTGVPPAKKRKTSALGKLLNTMQGGDDDSSDSDGGYGFGGFGGRGQAAPKGTGYSGAAHEDRSGEIAAEKSQFLKDQTTAKLLSQVRAYLPAVKRGHTTDLLVHPTALAHLRRRSSFVSDLLRNDSLMDMSNRAEIYHALFDWLEVVSSHEVLASMLAMPQMRAVKAVPGPDDDTVEVTYEGAPSPRELLETVVIQATAALKGLSSTSAPEASDPDSDELDPLQQSLAEAQKRKEKQRENAEADASDRILDARTEIDRLLVATKGRAFVNRMLESLPRLYETEEDQPKIETSATDETTMKVYEEWAQRVRFRYCDLHDPGDPSKIKYAHAYNNNIQTLVGTRSLAIAKELAILTTSLPAAWGSTIFIRVDDARVDRIKAMIIGPEGTPYENGCFLFDIFLPLDYNHSCPLVKSMTTNGGKYRYNPNLYADGKVCLSLLGTWSGPGWISGKSTLLQVLISIQSLIFCDEPYLNEPGWANQAGAYSANVRRMVLVDAMANNLKNPPFPFENEVKTHFRLKAKAIRAQLDRWKAEDDGKATNRDYFGVSPPNTSSGASSSQTPFDVAAKHLRSLLDELDPVAPSVVDSATPSASAGPSTSKAKKTKAKSGAKGTRSSSRLKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9T9</accession>
    <name>K1V9T9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RBCX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254361_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9T9"/>
    <dbReference type="OrthoDB" id="2575593at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1400" mass="150708" checksum="763B46494C779B43" modified="2012-11-28" version="1">MATTASGVAPQRLEPFDGLRRARRGVLPGGQRSVEGHRGRDDSPDGLDQTSQTSQSPASARHRRHPPPHQTFSDQAPSFPHVPRPSTFPSPSPIPAVRPEPNGSPAGSSRTYPRSVNNANSQALAGPSWPSSGNLTDLGGQNRPRPSLLPSITSPRKRYHSFNKHAPSNKASIKSHSRSHSLSAPLSRSFLPDDSAALPSSDIFPPPNFASHSEAVPAPKSRRSTSGQASAPFSVDFFADEKFLTLPPLPPNPSPTPAPRLLRSFRSRIPLPVNPFRGLAGAPGPIDEAEASTYPLPLVAKMVNGAREAALGTALRDGSDPTSTLEEYAWRSLIARVRVRDYCEGATFAVCASSVNHVRVAITHTPTRLLFPYDLAADAPSGAHTPPIHTASNLNAITRKQVVDVIVRLVRERAPIEARVLEIVLEYIGHKWHSSEGDVDIVSKKLFEIVSDVEANEPSKCAGAVGTIQRLRFQLGLVSAAQLASRLNSLPAFIRDSTDLDVNQLIHAWAVRRLNTSQLPQFVADALFSIRETLSHASHREAVGGVLKSLGLDGRRLSGKESPPRGRNRVTSRSFQTSPRISPTKRRTMPFPHWLPRNSTRFNNGEERRPSLPTLLTPAEPANISWPLPMHGQEAGVPRSSPDGSPCGTPTPTAGASQAANSQLALLDPYSVRIAVVDQILELRYRLGADADGWFLGTGQDKAAEIVNHFHGCEELRDTIVELRRTFLLPDPAVSNKLGLTIVPLRPRVDTLSVERPRIGLHVTTPSLDTVPVIHERDVSFDLDQYMADISHDPDASGSTLKAEEELVAASEEDSAALLESPGLLVGPGPETRSSVSSEVSHFSFASSSSALSGGRRGSTISDFVICEAVRVAIDHGSPSQATSGPTTNDHTSPKTVPRHSKSLSMLSDPDMYTRVPELRSRRSPHRHHVAMPSLSAPLGTTEFDLESAGKPVPGTTQECSSVPLISPIPKASPPEVDFSISPVISPVTSPMVTARPSKEFQAVISTPPSPPPDIESSAAARERSYQRLSTSPIDRAGSRTPTVASPEGRSRRHRQMVIVDGEPISPGSTKTPLGMVLTLFSQRKNLTPNAVEQILGQAVQVEEERMAAQGEEFDAEARVRLAWLLEQVANELSQPELIAAVQRVLSRLSNREIPVRRPSSPTSFSTRSSPPSPCSPFAVDKGEAGEARRRKSTLPHQHRSTAPPPPPSSFGSRMYGRRDLTITVPPRARSTIQVTSSPPSSPSVESASWTYSPSPEMTSDSSPSLYSSSSLYSTTMSTAVSTAFNMTASSEESFSTSPVSLRGPPSSKPPMVRFPNYTRGMGTPLQRQKSGATYSALSGKQRVSLVSSPNSSPLLPCTPDQFSGSFESLESAKGIRRSPLRPQPPKVSPPIPLTDVHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9U3</accession>
    <name>K1V9U3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9U3"/>
    <dbReference type="FunCoup" id="K1V9U3">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034867_1_0_1"/>
    <dbReference type="InParanoid" id="K1V9U3"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="483" mass="52790" checksum="2D148D2EC4E4774F" modified="2012-11-28" version="1">MSAPPHVKLTAAQIAKQAERKAAKLAKRAAAAANGNNGMSEQELARRRILKREWVETGSSEKNRRAKITTWNLDNGESQADRQMLAQTLVRRDLFPGSDCLRFSDRKPMLQSEMEAMKDTDVVCLQLTPGMRPARRRPLLCAGAHAAASERPREETRPRDSLPYLAVRGGRAARPVARRRAALRVPQRSDGARRVKADEEHCSPRRAARQAERRRDHRHYDASLTHSFWHPKFEYERARQLIVLLRAARALQSSRPTWPILLTGDLNTQPREMPYQLLASRGPYDPKIVHGFEDSRLVHTSVEKVGLPPPPPSAGDDASTSGTGANTPAPSTPAPTEPKAEKGDDGEGEGEGEGELPDSNEKSIANTRAPTEDDGILSLSEVERLAAEVLPQPARSAYASTTWGEETYAARGGLEGIQRAEGGAEPAYTCFTPLFRLTLAAEALPTAKAAAQAEAAGEAIGDRATKQLKKLSNTKLTSPRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAB0</accession>
    <name>K1VAB0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAB0"/>
    <dbReference type="HOGENOM" id="CLU_022204_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAB0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="604" mass="64221" checksum="ACC27C05478A62CD" modified="2012-11-28" version="1">MPKPAQTTEQPKPQTTTQGPPPKPTNNGSNNQNTTPKPPPPPPTTSHGNPFGIGGYGGLSFGTDGIEHSGGLGVEIGGKTYGIDHNGGIHWKRLEPRAPQLPNINKTVIEDFTGDTYNWTVNVPTGNYRLAAYDTQTGIMSNSHIFEVVDGGTSCMTAADWGDLPTGLSAGAIAGLVVGLIAGLSILGAIFYVLRRRRRSSGHRQGHGHGEFWRVHSNHSVESFGNLGAGGRSFRVPKSPREAYWDDPASAQYELNEKGSHYYAGNTPPLPSHTFRPLRPPLPDLPPTTPRADSPWDSDTIATSDRRFSRDLSTHTGTSHWPPASIHSGNRSFMGGSMLQPTVTGHSIAATAHSIAATAGSFQDRMPPSIMEVRAGVRSVAMSAVSSMATAGDREPPVLPVSPDNTGDTVDMLDISSAYGGIDSTGGGYSHMERSSRPENPAWVPQTPSASACKPLSDESYTPSSPVPESSAPRLLAGPTAPLRPKPRSPDHARAQTGSGAPEPASSEAGAGHAREDSESSGETASTTTAHIQKTMNNLKQQHRNDSDNDIARSFPNTFSFLEHPYSMPNAPGDRVSNPLSQMWSPSDGGHSDWSHWGRRTDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAE6</accession>
    <name>K1VAE6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAE6"/>
    <dbReference type="STRING" id="1220162.K1VAE6"/>
    <dbReference type="HOGENOM" id="CLU_073161_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAE6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851711" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35448" checksum="F4463448E28E3F1F" modified="2012-11-28" version="1">MKFAIAFALLASAVSAAPHIVQLEMRDDCVGKRFAVFAIDNSNTVDKQDPDNVRYEVPRKVFEKMSPEADKGAVLIGSWNEGNRVAAPLGPVNNLRWDTPAPGRGDVKADELVVAATTHIKNNVPEEFKDHTAIILLTDGFTVTDGGPTSEVNNAFGVKIARAIHDAAYEGIRVHWGHLNAQHDRRDVSFYNTASRDSGGFFSEINNGGEIAGFVDQVFKKGLTNKDEECRAKPQPEPSKQPETSQQPEPSKTPEPTKEPEPSKSPEPTKEPVPTSSCPAPVVSTVTEKVTETVKETVTAPAPTATGNVCFAPCDAPGAKPLTNVKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAM1</accession>
    <name>K1VAM1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAM1"/>
    <dbReference type="FunCoup" id="K1VAM1">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAM1"/>
    <dbReference type="eggNOG" id="KOG0766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634899_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAM1"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="115"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="232"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="331"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46719" checksum="749AAA0DD1AA4C72" modified="2012-11-28" version="1">MTKLSCKCEGWVGSRLSRDLFRSFTPVCPPTTCSNLLSSPFTSVSPFHPFPFSLRESTLTPVRIQLARHVDSARRVDPDPDDVDLNLDLDCGHDNESQAESSPPPALRRTFRPHERSLSAAAGPAQDAPAAGLRCGPEEVISYRLRKATTSHAPANLRHKLLPVIKQVVRDDGVLGLWRGTEATVARNVPGVALYFYMLSSIRNELSRVPMFQRAVQPADSSASSRTALAALSPTGNLLAGAVARTSVGFVLNPITILKARFESNAYSQYRSLTGAMAHLWRTEGVRGLFQGFTATAVRDAPYAGIYVVFYEWCKEIVGRTMALRPDLGIPNAALHSGSAVTAAMLATIITSPADCVKTRMQVAPAQNPNIRSALVNIYRDTGIPGFFSGSSMRISRKAASSAIAWTVYEGLLLFMGKQGKLGKGGKDEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAZ7</accession>
    <name>K1VAZ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAZ7"/>
    <dbReference type="HOGENOM" id="CLU_1422355_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAZ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="191" mass="20521" checksum="C1488C5E25BA24F7" modified="2012-11-28" version="1">MKGPLRAAALNVSEVLSYLNVFGSRNGILTSIVRHAPVLLRSGKGEQKCALVGATSGHRTTLNPNGMKVPPTPTLLEMRLTLDADELYSIAKSRKTILDDEGHQGDDHSRPPPLLRSDVGGHVLNDRAPGAITPDCESDTASGSGSDEEMDVDNWDQPDLFDGETFDEDDRVILEHQCREPGAPGVVAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCU7</accession>
    <name>K1VCU7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCU7"/>
    <dbReference type="STRING" id="1220162.K1VCU7"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_8_2_1"/>
    <dbReference type="InParanoid" id="K1VCU7"/>
    <dbReference type="OMA" id="AFNFFCT"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="43"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="56275" checksum="F0C0249C7D281FCB" modified="2012-11-28" version="1">MPSETSPLISPTPTSNGVGNTHAAPQRTYTNGDREVEVWKPGKSGFWATLLNTLGDLIGTGLLATPIAIAHAGWVCGPLALVIVCGVTLWTLKILLRIIEKDRRLRNFTDVIGYALGTRGEAIVTFLFVIEVCAWVIALIVLFSDSLALVLPQYTSDQWKLLGLLFIVPTTFLPLRYLSFSSGLGILSTWLLVAILIFTGLVNPKAPGSIRDPAPTDLWPAHGFWKLCSVFGLLISGFGGHGLIPNLIHDMADPHQADLVCDFSYAVAMAVYVLVAVFGYLMYGRDVSDEISKDLARTPGVTKALSTFAVWMVALNPLTKIALGIRPLADMIFTRWGLHKTELVPLGAPTPRYVTRPPSPVSEAEIENTENTAVGNLLQDEQDAQSAAYQRALRDAEAVNESGFSAYVDASSSFSRVGYDPAASLFQPRNAAAHARRERIKALCRHATRLVLAFLFVAGALAMPSFERVMGLLGSGFASLTLIIIPVWAGAKVFGWRWYHWLAIAVSAVAGVLGTIAAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEE4</accession>
    <name>K1VEE4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEE4"/>
    <dbReference type="STRING" id="1220162.K1VEE4"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_3_1"/>
    <dbReference type="InParanoid" id="K1VEE4"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="179"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="440"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="647" mass="71377" checksum="8FEAD9FDC4A6E9BE" modified="2012-11-28" version="1">MFARVSDKFHNRKQQASPLKSPQSPPANAVSPGSAVSPTNSTTLPQSMNQGAAPSPGATQSVQPPQPVASMSAPAQPGMEGVESVASPQSMAGPAGGQPYEVNRTMSIEMADVSNLSLQTPTETRQGSVEEERMREKARSAQEQAQANLHHATQQARVAAINAAATQAALDTATNPSTGSKTPVSGRGQALRKTAGRYALGDFHIERTFYAIKVLNKEKVVKMKQVEHTNSEREMLVRVRHPFLVNLWGTFQDVNNLYMVMDFVAGGELFSLLRKSQFYAAEVALALDYLHSLDIIYRDLKPENILLGADGHVKVTDFGFAKHVPDITWTLCGTPDYLVQSKGYNKSVDWYALGVLIFEMLAGYPPFFTEDGNPMKLYEKVRRQVVNTDQQIIAGKVRYPTYFDALAKELLKNLLVGDLTKRYGNLRAGSADIFAHGWFAEVDWDKLYRREIPAPYVPKIEGEGDASQFPSKLTALQHPELSRHLRVGAGESASRPLFPKDSKRNQVERKTIVALALLRSHPFRSLPLHVRCFREDVHQSFTALAQPDNGAPALFKSTPAAIIAGVKALPELDPRVQVTFNPSGYAASFKRGRIESDDQLDLKDDGFRNGDRSGEKWKRLQQTSGQRRCYLCAAEVDTKVRVSPLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEV3</accession>
    <name>K1VEV3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEV3"/>
    <dbReference type="FunCoup" id="K1VEV3">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEV3"/>
    <dbReference type="eggNOG" id="KOG3295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075696_1_0_1"/>
    <dbReference type="InParanoid" id="K1VEV3"/>
    <dbReference type="OMA" id="IQKNHFR"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="23648" checksum="393C32F26F6617D2" modified="2012-11-28" version="1">MVKHNNQLQKNHFRKDWQRRVKTWFDQPGKKKSRRVARSKKALASGAAPLQRLRSVVRCPTQRYNIRVREGRGFTISELKLAGIPRKQAKGLGIVVDHRRRSKSEEGQKANVERLQAYKERLVVFPRVHGKPKAGDAQGEDLTAHITRELPAIVNTYTAEKPRAITEEEKSFEAYTTLRKARSDARYAGIRAKRAADKKAAAEEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF36</accession>
    <name>K1VF36_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF36"/>
    <dbReference type="STRING" id="1220162.K1VF36"/>
    <dbReference type="eggNOG" id="KOG2464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421028_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF36"/>
    <dbReference type="OMA" id="QDAGTDC"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="466"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="651" mass="71624" checksum="BB068EC645BFD2D8" modified="2012-11-28" version="1">MARRRRPSKDRETSPATPHRREPPTTPLKPKATNNETPLKPRDNNTSTPLKEKKTEKGAKKDAPLKQHAAQNRRAVYRNSPERAHVVRKPAPRRIHALRAMDRVEVTIETRSPSPKQSEPQVEPKTREKPQEKAESGNEAKPKPKATAKPKTDDEGEPKPKAGPSKQSKAVDEVTQQVVDLTLSEDEQPVKRGPAPRKPRKAPKIVKPDQRADPTPQPSPEPEVRPDLPNESLSRLLAQCTVSQPVAFSDVFKHPAFSTLVTGSELKKQGEASYSEVFRVGDAVVKVIPLLGTDRPTDDGEDIPDCSSADDVAREIEVTRRMAQVPGGGFVGFRGAFVVTGSYPAPLLAEWDAWKAERGTESPRPIFPPEQQFALVVLDDGGGDLESAHFDSHSWTTMAAVFWQVCDAIARAEKWTQFELSSPPPPTSKPTNTNYLAPSGVTATMIDFGLSRLSIDGEVRWTPLPEEVYDGVGAQWDVYRAMRDVIESQPPPAEPEPVRPPSPVPLARRRSRRTTTRVVQYVLSDSEDDDDEPSYVPPISPPSSPLASPSSSRTSTPPTSTSSLSPPTPWTAFVPASNVLWLRYLCTYLLKAARKPYSRKSTSAAKEAARQRQEAAWSMLCDVGAALDPEMGMFDSAADVRSWGEECGWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFJ2</accession>
    <name>K1VFJ2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-CoA transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFJ2"/>
    <dbReference type="FunCoup" id="K1VFJ2">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFJ2"/>
    <dbReference type="eggNOG" id="KOG3574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020502_2_0_1"/>
    <dbReference type="InParanoid" id="K1VFJ2"/>
    <dbReference type="OMA" id="RRKSWIM"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="75403" checksum="407275D0CDABEFBA" modified="2012-11-28" version="1">MTASTPNSLRLRARKSRPSVLKTRAVTNLSLLPVDCHPTQPATDGPGRHPEPGHRPDRLGSSLADTSGISTSPTSQHTTSPASTPSPPTVTPSSPADDEQLQLELEATDAMLNPASVRGRNEDLDDLEEKGLLIGGEGSSLELDSGGTTPRRRAKGDSGHYEKLDLGVKEESGLKSKRDQQAFALLIVLCELAEGSGIPYPQSISSTGQVLQKDYLLQGIPLGLTFGTLPFLLKAHLSYSKLAVFALSTWPYSLKLLWSPIVDAIFVPKWGRRKSWIVPVQALVGLMLWFIGARVETWLKGDININFLTMMFGSLILAAATQDIAVDGWALTLLSPPNLSYASTAQTIGLGIGSALAFTVFLALNSVDFANRYFRSVPADVPLVTLGPYMKFWGLIYLVVTVWLVFFKTEDPVSATDPDLDVKKVYRVMWSIVSLKNIQSFLFILLIAKFGFQVNESVTQLKLLEKGLSREDLAVASLLDFPAQMIVGWLAAKWSRPSQSNNEHRHPLSAQQTRQAAATGVLKVWVGAFWARLAMAFIAACVVWLYPSSGQVGSGYFSLVIATILMTSVTNTIQFVGITAFHTQIADPLIGGTYMTLLNTVSNLGGTWPKPIILRLVDLLTVSACSITGAECTTEAGKEACSASKGTCNIKRDGYFVMTFACMSVSALLLLYHILPTIKKLMALPMSAWRVKIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG56</accession>
    <name>K1VG56_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG56"/>
    <dbReference type="STRING" id="1220162.K1VG56"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="K1VG56"/>
    <dbReference type="OMA" id="RQIAHME"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF129">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="129"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="541"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="426"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="766" mass="84245" checksum="9DA0FDEE81B737F2" modified="2012-11-28" version="1">MITIDQVVAAAPPDVRETLDDDTISYLGTVIEGKTDPDDVRRALAPFLGMGPADLDRMFAKLSLSSAPTASAAPDPSSLLAEVETRPSTPSKKDKKKRTPAAPTGPSIMAYSQQSRFHSATLSTLSTEIDLRGVNVTVDEAELLVDARLWLKSGTHYGLVGRNGTGKSTLLSVIGDHSLIGFPENIRTLYVQQLDVVESDESVLSAVLSSDEEVTKRVRDTERIEAAVASADDGKIVDAITTYIERIANERILAAQKIATLRSGARGKKARGVALKAEQTMLASVREEVYGTSAESEAQVAARVLATLYDELSKMDADSAEARARAILAGLDIDEETADGPVSALSGGWRMRVALAKAMFVRPDLLLLDECTNHLDLAAIAWLQEYLSTLDVTIVCVSHDRDFLNGVSQEIIRLSDKTLSYHPGNYDEYEQNEEELAKKKQRQHEALQRRREHVQKSIERFMKHARSSNDDKVLGQVASRQKKLERMTGMEKTEDGKRFKVSYWAGYHDTMRPEIELKKAEASVDLKIPTPETLRGSGPLISLSSVSFSYPGRKRRVIKSVSLSIMPGDHIALLGLNGCGKSTLVQLLSGALAPTHGNITRHPGLRIGHYTQHFVDELSSVKYSALDILRTKAEKEVAEAIAKGREATAPKEGDLRKWLGGFEVSGQLAIRPVNTMSGGQRARLAMALMLWERPHILLLDEITNHLDMYAVQGLVAALNDYEGTVVLVTHDRHFVRETADDVYVLEEGRLRLLEEGIDEYVAQFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGK1</accession>
    <name>K1VGK1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGK1"/>
    <dbReference type="STRING" id="1220162.K1VGK1"/>
    <dbReference type="eggNOG" id="ENOG502RBGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994629_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGK1"/>
    <dbReference type="OMA" id="SEHCEEW"/>
    <dbReference type="OrthoDB" id="2575097at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="280" mass="31196" checksum="33F932F6CB66E7A7" modified="2012-11-28" version="1">MQSHDLAESSLQRLSSVSPARFKSALATSRRLLESAEASSPSGRRKRPATSSPTTSPTKVTTADAMSPFQTPRKKFKYTSGLDLTGLVHAHSPSKGSPLKQSVTPSKRREKREIVDVSDSDNEVEATPTKRRTPAAATTTAPRSPRSARQKARDQKEKDGKAAFLALRPGASDVPSIQVTDEEGEDDLTPRRRSPVRRLVDELQPRPTRKHTRRRMDWTFRETVWASFDPEGEAHKRRRAELEEILRPFENVKPADGPAKTVDEIVLEAWRARMAAEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGP1</accession>
    <name>K1VGP1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGP1"/>
    <dbReference type="STRING" id="1220162.K1VGP1"/>
    <dbReference type="eggNOG" id="KOG0020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="InParanoid" id="K1VGP1"/>
    <dbReference type="OMA" id="ALPKWAN"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852112" evidence="7">
        <location>
            <begin position="24"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="168"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="763" mass="85246" checksum="8D6ED75F266A4E8A" modified="2012-11-28" version="1">MRLVRLLIAAAVFGSHAIASVAADESAVADAASASAADTPVSNSDGVETFHYESDIARLRSLVIHSLYTQKEVFLRELLSNANDALEKLRITALTEPDVMSSGEGNVTIKVDLDEGGKTGTLTIRDTGIGMTKSELSKNLGTIARSGTNEFLKLAEESKGSEGNLIGQFGLGFYSAFLVSPEVKVSSLPPATKENPHPVQHTFVSSATGDTFEVYPDPRGNTLGRGTEIVLTIGEEDKKFLSMKYLRSLVDKHSLFSTPFPIYLYERQRPKNAVGEEAEKPEFLWVQVNDKEAIWTRDPKTVPEKDYIDFFKAINEDKTVNPLGWSHFSGDTASGISYKALMYIPDSLPKDWWTQIRNGINNVRLMVKRVFITDDLGQQFMPRWLSFVKITVDADDLPLNVSRENLQNTRFLSQLQRILVRKALDLFTRIAEEEPEKFKTVTRLYGNALRIGMIEADKGKHKIAKLLRFQSTKGDDVSFEQYVENRKEGQKQIYYMAGVGEKIDDLKKSPFVEKLIARGYEVLLLNQAADEPMMEALSSFAGMKAQDVAKKGLEYGDEELDKAEAAELVAAKEEFEPLTDWLKEHFKGQIAEVVITNRLVTSPCTIVVDSIGWSANMQRVMQQKAEAEGDPMFEMLKNLPKTMEINPKAPLIRGLLARVQAEPEDPELLETARVLVDTTLVRSGFDVPDTVSFFERVEALLRRSIAVDAAAKTPEDVKPAPPVAAEALEEESVEDEIPDEDIGQDDEELEWEESKKQYFHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH13</accession>
    <name>K1VH13_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02297</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000252">
        <property type="protein sequence ID" value="EKD03410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH13"/>
    <dbReference type="FunCoup" id="K1VH13">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH13"/>
    <dbReference type="eggNOG" id="ENOG502RDEI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166246_1_1_1"/>
    <dbReference type="InParanoid" id="K1VH13"/>
    <dbReference type="OMA" id="MEENTYN"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="76" mass="8541" checksum="49189733BB659E75" modified="2012-11-28" version="1">MDDPYTVKAQSGSLITCDSAAKQILLHLDSQRTGNYKFISADIDETHLLVRTEAVEEIKAALQEELEKNTYVKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH22</accession>
    <name>K1VH22_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH22"/>
    <dbReference type="HOGENOM" id="CLU_486787_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH22"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="560" mass="62730" checksum="5ADDDF9576CB3CD1" modified="2012-11-28" version="1">MKRALPLNTRDRPKRPRVWDWVEPAPTHISLPLCAKTKTTTPPKTTTPPTPPYTPAASAVGRGVPGTIDHLAYPHLFEAVLRAVIERRDATTLRALRGTSRAVAARIDSAFLSDITYALETAEATAPLKMARHRPLPPQSRLLGLPWHGQAVSTATIEVGPCECHAKFTPDTADADADAEAEVDADADAVMEDETSSKCPAHAHEARIRADTLGRLQYVRFVGDPHAHAANWALEADTEVHVLDMFPRKGNGWTRMNRATLDSRRIALQSAGSPPPACDTEGVEDADDAEDVEDVNDADSDVPDLDIGAPVAPVEGVGTLSLPRTPHDERADRPRRRVLHFRLHSEYEWLFDYCMLPPSDIAHTTVLVSKYQGRVQLEAPEDFCSMCSEASGCRTDPGMLVHVKPDPTRHLSPAEGPLFGLITSLADDWTQRLRHLLKTPYPPPMNPHTAGTITFVGTERWENRWIQSRPNDVLLPSGYAREKIRQCFYWRCLSNVQDAILERFTDEIDYTTRDPRIKRWWEFVYLFINEESCFRFLSMDEYAAEVGERELELVLAEDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH56</accession>
    <name>K1VH56_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000390">
        <property type="protein sequence ID" value="EKC98456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH56"/>
    <dbReference type="STRING" id="1220162.K1VH56"/>
    <dbReference type="eggNOG" id="KOG2065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009597_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH56"/>
    <dbReference type="OMA" id="QLSMWLL"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="321"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="767" mass="84289" checksum="ABCDED22E521A329" modified="2012-11-28" version="1">MLAELLLVLGGHPSSLFLSTGVSPELASYLHPGEVASLNTLCSLAANYTRVREWCEVTQAEARAAILASSRRKGKEREREGREPGQYVAVLAGAVREVLEEYESLLVETEALVLSRDPGTVQPSEDKDGQGYVPLSLLLATFDAWHAPMAALSALVTHLEEESTPGELMQHLSEQSATGHPTLRRVFTQLLQRLWDLWLTHLVVFLLDGVASDASSPSSPALGLDAGADPPHRLYKLNADLLPRSVGGPTRESILYVGRVAATLKREGRALPRSLVEKTRRDIMASKPEELDAAVQRARAEVGEWLWRHVLTGEQVAEAIESFANYFLTRDGEFAVNAIREISRLRRDRLLLSNPNSSSSVIRAHDLDLAMLRASLGTAAEADRALEHLSWSMPAGPLRPLSRPAEDDGTIRGLFSPALLGTPISLSAEVKWPLDLFMTPPAVQAYGDMHAYLYAIRDAHMRVLECWSALSGAQRRRRQYTGIDEGGAGAERDERVRLARQAWGTVRAMLFFLDQLLGHFMTDIVGVQHKRLLEQIRPHVPAPAPVHARARGLSNVRASTPTPGTPRNPRPRPSTPGLGTPGLAPDAPAYLDFLTLRQMHARHLAFLREGLFIAERDSAQLIRDILDTCKRFAGLVERWGGDVLPELLLDDSNDRVSERARAVAEISDSLHEQMGEFFRLLLESQSPTEKEAGGGGASMTRGSLTRASTSRARVTQIMAVNSGGDAEGDGLMARHVEQLLLRLDFNGVLTQWQEGRDENVLPPRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH70</accession>
    <name>K1VH70_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH70"/>
    <dbReference type="STRING" id="1220162.K1VH70"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021989_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH70"/>
    <dbReference type="OMA" id="YDQPHEI"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="306"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="562" mass="60220" checksum="C3D2314BB809EDE2" modified="2012-11-28" version="1">MATSLRIGARAAPLAAGAVLGYAAYTLHNSKQQLLNPIRLDDSPFPTPTTLLPEAIHISPSGVPSTITPLGWGTNEYLTLLPTSDKKTLKNPTPLPQLGATALRHLVIQEKYGAAIDARGDLWMWGTDYDPSGDVGKSLSGRDLAEVAAAPGKLFALSKRGRLYAVSADRSFQEGNVPSRAYWKRLASRDPGVDYVELQPNVRLGWGEKWTSISVGSNHLLALTNKGRTFSLPLNPAANSHRQLGTRQTFPVPATMAEAVRDGPTLPPASDPRFETKLTEIPALSGIRIAQIAASDRSSFVRTADGKVLGFGANDYGQIGLGNRTTVATIPTPVEIAIGKAYPAGTRISCSNVSAGGATTFFTIEREDGNKKLVDVLSCGNGQNGTLGTGMWSSACYEPAKIKTGLQEYSEATQELVPLQITSISVSPSMNTHAFAVLDTLQSADPKGKKQNMFGKDVLVWGGNIDYQLGTGKRSSIATPTHLPSLIPHAMDTLVASRTEQIDTKDSPGGLKQKPIHFTRLQLHQTKADAYDLNGKLIKRGVRAEETIVPGYNCSVLYNRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH80</accession>
    <name>K1VH80_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH80"/>
    <dbReference type="STRING" id="1220162.K1VH80"/>
    <dbReference type="eggNOG" id="KOG1996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025002_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH80"/>
    <dbReference type="OMA" id="GPMSEVI"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="662" mass="69977" checksum="75E1AC4F62F34FCB" modified="2012-11-28" version="1">MSLFSGITFTSEKAKSLAAESAANAEGSASPSSGTSSVPKPAAAESSTSATNGQPKPKQKEKEAKPSAALAFAPRPKPKRPTAAQFMSSSTAAPVVEAAPVLIVPPPAPSSSVSAPSEPEVVVPAMTLAAAEKAKRAKGEAPEQPKKKKKRHTFKPDEEYDPNRPNDLGEYQHYRRKVREERLARRRREGSESSYYSDSSDAAPRRDAPKLFAPPRELTQGVRMASPPRRSAPSAPPPQQESGEDAYARRAAMAQSGEDAYARRAAMAQSGDEAYARRMAMSAPAGVPAAAGPRAVAPEVAQPPPPSMPPMPPSLPGGPPRPPPSMPPMPPSLPGGPPRPPPSMPPMPPTLGRPPAPPAMPPMPPNLPLAPGGPPAPPALPPMPPTLPRPPPAPSTEQDAYAKQIADKRAAVEALAAKFGLAKKPAEPEPQDTSVPFAERSESRPTPSPLHLPPLLSLPHTPRLAASLPRSKADNQVMKKWGHVSGQALKEGGLTSALSAEHFQPSSTSSNLASANLSKRARAKAAARAASTKWKQAPNARGRIIDQDRVGRQAVSRERFGDESRIAVIEGLGQGPDVVPDGLVETVGERASDVGIVERIVLHLVDPPPADERECLRVFVVFSGMAGAYRFVTGTTELDGRPVRVRYFDEGRFERGDRDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHA4</accession>
    <name>K1VHA4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHA4"/>
    <dbReference type="HOGENOM" id="CLU_1435387_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHA4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="189" mass="20056" checksum="F0045534003BBA7C" modified="2012-11-28" version="1">MGAKSPPLRVRPPSAEARGGGWHETPPGVMVVRRDLQYATAMGDGADVSLPADLRGGLKQIRPEAVLRCVTLVPNERGTSSGRTDRGDEGEADTSSKADSSDVMCCSCYHAAAHHRPPPVTIAGEGGVAHDSQVLRRGPGSTEKTRASRHIRRRLLDLSNQQPPLVFLSTQQANSSPLQSPSPSLLAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK50</accession>
    <name>K1VK50_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK50"/>
    <dbReference type="FunCoup" id="K1VK50">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VK50"/>
    <dbReference type="eggNOG" id="KOG4032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074896_0_2_1"/>
    <dbReference type="InParanoid" id="K1VK50"/>
    <dbReference type="OMA" id="QSNWGGP"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23203" checksum="2080129E0469C4CE" modified="2012-11-28" version="1">MPSNVPDQQAPEILLFARGVMALFDLWPALTIAVKEEWGGPDSADKKLYLLSAVIDAFEQGASYTTPDAAGVVHVDPKSAADPPLDEDQVADMLDQYMSDEYEAVLEDGSSDMIAKDVSRLWRDCVAPGERSAEDTVGALERKAAEISKKPVHATKHDENESDDEEGDWSDEDDDDKDEVPQLVESKPKEKQEPIIDDDGFELVQKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKQ5</accession>
    <name>K1VKQ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000320">
        <property type="protein sequence ID" value="EKD01341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKQ5"/>
    <dbReference type="HOGENOM" id="CLU_474234_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKQ5"/>
    <dbReference type="OMA" id="PCRRDMA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="575" mass="58751" checksum="E56982AF04DFF2B0" modified="2012-11-28" version="1">MTHKVSNVSNVSNVPQDSASQPPSPVLVSLQDGQGNVSKDSVPSPDIVMEHGPVPTLSQNEESAQSEDRVSSETVPELEKLHISESAGDKAEPAEGAHEAEDLNAADDVEEAEFVECDCASRDQCGRGFPFGFGSRGGFGGRGGFGGRGGFGGRHGHHGPHAHGHGHGHGHGHGHGHGHGHHGGPHGGGPHGGPFGGPLGHSGPCGHAFGPDAFGPHPHRGHGHGHHAPGGRHHGPWGHGPCPPGPAGPVPPCPPGEHGHGPHGHHGHHGHHRHHHGPHHRGPHGPHGRHGPPPMPPMPPMPPTMDGCLPPPAPPLGGRPCPPGFDVPPPPPCGCVPPPPPGFANVSDTSSSETESTSESDSNSTSDAAPVDARRRRCHGRCARGHRQGSPYATDAPEEHRGHHGHRGHHGHGRHHKHGKYGKHGTHGRRGRHTDADADDDNDWHARRGRGHGHHAHGSFPPFGGPFGGPSGAPFGAPGDGFGGSFSGFGPFGGFSGFGGGGRPGHAHHGHSHGYAHHHGPGHRGHHGHHHGLGFGSPFGPSGPPFGGPGGPGGPGGLGNVRSPFAFALFTETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKR3</accession>
    <name>K1VKR3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKR3"/>
    <dbReference type="FunCoup" id="K1VKR3">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKR3"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="InParanoid" id="K1VKR3"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="494"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="613" mass="69259" checksum="702BA56D66F9829E" modified="2012-11-28" version="1">MATIPEKHQLPELPVFPGSDYEREPIQRFRAAAAVQIGEAWGEDPAKLFAGVDTGKRGYDLALAIPRFKKGKPDEWGKKVVEAFKPGPYLASVQHEGAFLTFEMNKQNFAFAMLNTINEMGKRADAHPESKTEAYGTSTAEKGKKFVCDFSSPNIAKPFHAGHLRSTIIGAVICNLHEAMGWDVVRLNYLGDWGTQYGLLSIGFDRYGDEEKLAADPIRHLFEVYVKVNQDNDADKAKFNAGEITDPESTTHAQAKKVFKAMEDGDPKALAQWSRFRDLSIKKLKETYKDLNVEFDNFWGESKVKPESMQRAIDICQEKGLTCEDRGALLVDLKKWKMDRAIIRKADGTTIYLTRDLGGAHDKYEMYNFDKHTIVTAAAQQLHFKQMNKTLELMGEPTAGKINHVSFGTVHGMSTRKGTVVFLDDILTEAKEVMHQTMRSNEAKYAQIEDPEETARIIGSTAVKIQDLTGKRINDYTFDIKRCTSFEGDFGPFIQYSHVRLCSVERKNPNVAVREFASDIDVSVLDQPKIHEILYNLALYPDVVKSAYKFDEPSTIVTWCFKISHLVGSAWENVKVSGAEQKEAEARLFLYTQIRRVLNHAMRLLSLTPIERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL17</accession>
    <name>K1VL17_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL17"/>
    <dbReference type="eggNOG" id="ENOG502S7B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497995_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL17"/>
    <dbReference type="OMA" id="WRDFHIN"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="292"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="547" mass="62295" checksum="5F8A4EC2CD3D3194" modified="2012-11-28" version="1">MPMPSKLKQSRLTFSSWEPLRKAASERGSSQQSSPASSPLPPSSPPPQPSPKRTPPRSTQPRRTRLQPMKLEDSSEEVSDDDFNAVRLGPRSPTKPTQRKGRFFSDDEAPEPTARRRIASSDEGSGKDESSIEFLGSDPQSSPPKSKGKRKATRRRVDPDSDDSASEDEAPRRKLRPRRHQSSDSDSPAPRSRRSASPKPRKRRRSNLHPDPDDEPASAATEDEDARAEIEMDEPERFTATTRLRETKESAWAANLRRLKESRGGNAAEYVSSGSDKDEGDWAYEREDELDDFLVSDDGEMLEELPEEFSHKRESTEYKFKVVFQYLLLLAIKGPDILPLSKSNADYFGRQLRDVRNLMKGFRDSISSTLWKPEFRKALETYPIWKQADLTEREQYCDGCNRRNQHCYHTAWLRGQPYDRESHEVLDASDSEDAEEDTEDDDRVLGNMVPAEGTRLSRAPALGAPDVLLYQVAVQRPYMSSGEQRDLASRRRISAGLVRKFSRGPLPNDVEDVDEVTEWMDSQGLMRDSLDWLGRVEGRARRLERHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL65</accession>
    <name>K1VL65_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL65"/>
    <dbReference type="STRING" id="1220162.K1VL65"/>
    <dbReference type="eggNOG" id="ENOG502RBH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141774_0_2_1"/>
    <dbReference type="InParanoid" id="K1VL65"/>
    <dbReference type="OMA" id="MVMVVKP"/>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="84" mass="9642" checksum="AFDC6F011BF20BD7" modified="2012-11-28" version="1">MADNNEKKVENETKPQEEKKKLPQLGALEDDDEFEEGTVADGLQSTQEQLWEDNWDDDDVEDDFQKQLRQAIAERAGGDDAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLC1</accession>
    <name>K1VLC1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLC1"/>
    <dbReference type="STRING" id="1220162.K1VLC1"/>
    <dbReference type="HOGENOM" id="CLU_568818_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLC1"/>
    <dbReference type="OMA" id="HYNNAIN"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="567" mass="60024" checksum="467D9D52954FAE19" modified="2012-11-28" version="1">MLLLDTSTSLSTDKMSLREEVSLLAPITHLPISPDQLAVILTGDQAWLRRGIMVQGWSKDGYEETASLALACLAAALEIPLPRAASRCLALLDGRWARAADLYEQAVSQDSTDAKAWSNLAQARLNLQEYPQAFSAATRAHDLDPTNPKPLYRLALAQRGMNEPQSALSTLASAPQVPEIQTLSAEIKNDLEVQHLKSDPGSQAGLQSLREGFIRREGADGSTRSGEQQRAERARVWAGEDVRERQQESSAERRARDAALQKQAREEKEAKRRDAEGWAREQAGQTQAGQTQAGQTQAVQAQAGRKASGEAMDVDTTPPSTAPTTPSVSTAGNEPRNSFAALKAAKAARRSYADGGGGMPGLVPVSTTRTTPPAQNAPAHVRQPLVQTAPPSAVPSAVNTAVQSAVPSGVPSPVPTPNPQPAASQPAPPAQAVQPPQPPAAQRAPSQPAQPPQPPAQPAPSFAPPSNPHSTAAGAGLSLLRTLAGLSPQDAFAYLRHYTPAVISKVMDGLLDPDALGLILRALQAGAGSGNDDWIKQVIAGLKSNRRWRMTELMLPKAEREALARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLF7</accession>
    <name>K1VLF7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uracil transporter FurD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLF7"/>
    <dbReference type="FunCoup" id="K1VLF7">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLF7"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_5_1_1"/>
    <dbReference type="InParanoid" id="K1VLF7"/>
    <dbReference type="OMA" id="FNWLYGF"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45276" checksum="907CF43E078B8411" modified="2012-11-28" version="1">MFWLAINSWSGGQFVQLMIIAIWPSYARLPNAVPASQGATTSDFLSFFIFWVIQLPFIFIHPSKLKLVFNIKAAVVPVVAIGTLIWAVKIAGPQAGPILRASRNRAPAGKLRFIAFCTSATAVQGTWATLSLNIGDFSRYCRSPRSNWIQIFAFPLINTTVSLCAAISATCAYAVYNEDLYQPYDILAKWNTSPGGRAAMFLGSLAWALSNVTNNITANSISAANDLCSLAPKHVNIKRGQLVAVTVGVWAFVPWKILASAENFLAFMSSYSIVLAPIAMLMVIDFYVVKKKKFNIYEMYKPFGIYRYTKGWNWRAYVALACAVAPNMPGMVHAIDPTTEIGNIKYVYMVSNLVAYAIVIPVYLLLNKIWPAPEAIVDEPVHDIIDDKDEFDSHSDISPAQSGFLDEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLL9</accession>
    <name>K1VLL9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLL9"/>
    <dbReference type="HOGENOM" id="CLU_422220_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLL9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="649" mass="71027" checksum="3FD0D659BDA880CA" modified="2012-11-28" version="1">MAPVTRSKRIRSETTSPQPGPGDARSVAPTTRSSKRLRSGAASPQLEEGVREKAPAMGSSKRTRSGTAITQPESPEGPRRRKGARKNAQSTRAAPQAPPQAPPPTVPRAAPPAPPPPVPPAAPRKRTIPAELLSTICGHLFDDGAIGTLNAIMRTGPLGYTVVGPVLYSTLVVDDSFAAVLEGLGKNGRKRALFWNVRHIFFAATDTRAMVQCIARIVGHVAHYPLAADPRDPGPGPATPFATVDGETEPLFPNLHSVSIESRAFVPLALNPDSPALFLKMFCRPSVGKTVHQSFRDLTPQEPEPGFLKRMRFSDIAADGLAGRKGLDRLRRAQIRYLRAKRARAMAEVLGNPVALEDLLRLWNPETVTLHGFRFFHPGMGEWRTGGRGVDFLSWAQGRVRIFAPTVGSEHPADEGGQIPGIPGFQCRRKVGELGRRCACNQLGMWRRAAKFLGSVHVHSFPPNPPNGPLPPASRSAISKPTLELCNVGQNLPLWCGCRYAYTAAIQNLKTYVRGEGALMARLEEGMWTRRQDTTRLAYHLEIPHWSEVEGCACGLAGVQAGHDAKEPLEAGVLQWFEGDADGKVVPREQGCTTPHPFDEREVRSNDWVNDDSELWEDDGDDGYNFDRNPWLLMAVPRPQAQRARRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLX8</accession>
    <name>K1VLX8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_03968</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLX8"/>
    <dbReference type="STRING" id="1220162.K1VLX8"/>
    <dbReference type="eggNOG" id="ENOG502QPY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458693_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLX8"/>
    <dbReference type="OMA" id="HANTGCL"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852285" evidence="13">
        <location>
            <begin position="21"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="305"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="425"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD01731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="553" mass="57341" checksum="2DE5084489A030C0" modified="2012-11-28" version="1">MAPKLLSLVAAIGLATPALGHMALWHPAVFEGKNGPHGDNWDAQDLANPLFQRKKDGPGGWWFHGKVDEPPVDGEFVELVAGGHLNAELSCNRHFTTWGNTLGNYGDEKRACGAHGMRHCEDGDNASELKDVKGCAIAIGYESDPRKLDPSKMVVISVDYQCPWFKAARFEIPAGLPPCPPEGCLCTWNWIHSAFGGQAEMMQTGFRCNVTGNTGAQPLPTNPKVASKCPYDRNNCTTGAKTPFVWYQAEGNNVYQDFIDPPYYNWEYGFKNGAQDDIFTVEADTYTNTEWAPIAWNTKDHPVPQVTPATKANVPPVQPTLKITPAPFDFGPGTSAPPNGPATRAWTGAPAQPTAEAAATQTASPSAQTASGAPASSAEATGSTSGSPSASPTAAPTASQSTTEGSTGGEFWIGGDDQDGDEQNAAVAGSSASSAGAESGSASSASAASSAAQSGSVSSVASSAGVQSGFTSSAPASSAAQSGSATSSSASASSAIESSALGEATTSGAPAPTSAPQTPTEKHKTHGKKPKKCKPKSKRSKLEHARRSRRRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM14</accession>
    <name>K1VM14_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Centromeric protein e (Cenp-e protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM14"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002456_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM14"/>
    <dbReference type="OMA" id="MHAAREK"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="181"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1067"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1397"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1476"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="510"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="699"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1266"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1414"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1476"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1527" mass="166131" checksum="2037FB4B3EFBE2EC" modified="2012-11-28" version="1">MRWEKDAVLGSADHVSGPSFRQGRAAGWVTVAAFPCKPNDKNPLLATNVAESDQAPRRTLDIGQFEEPHSLPVQMPSTPRRVSLKRQRDGEVQDAEEEVKPRVKGAAKVEGPSTPKRKVVNAIEGTTPRTMKKREPLNARLANAAGSPSSTPPRKPVAIPAPVTSARKSVAPRASMVNQDKVVVCMRIKPTNSRFSTRAYEITDNALILSDAHPNIVRRGGKAAGRDAEYTYTFGERPATDKVAPMVEKAMAGFNSTVFAGKSYTMSGTPSELGIIPCAVDGIFDAITADTERAFLLRVSYIEIYNESLRDLLNNRRGPFNGDDAVQPQILYVDPLEEGIVSTPQDVVDLLERGNQNRKTGATDWNERSSRSHAVFMITIESRPRIGDGEEDIRVSRLSLIDLAGSEKAVSDAERRGEGKHINQSLFALREVVHKLTEKGKRGHIPYRNSKLTHLLENVLGGDSNICVICTMSADEAHCAETLETLKFAGRCSQVETKARKNISSEGAVIRAKDMEIASLKRQLENLGQQRMVEKDSSTSSTELSELAESVAELEARKAKLAQQISKLNGEILTSELPRSSTGLPASPPKKKRPRISDFTSTSQAANLGIGLGTPSKHMDRRAVSTMIRVPEERFQEFQDEPSPKDVQHSVMIEKLDPERNFDHDVTIASLRRTIATKEEAISKHANSLAELQPLAEKLPEVESELEKTKASLNRMEAEHAKQLKEAMDQLDELQKTRTELTESVAEKSKQVEALETSVADLKKSHSDLSAAHAAQLAKLSAELEAVKGERDAKATELEKLVAGHEKQLADAKADVDSHRSQVEKHVERITALEQAETKLKEILDKAQKDHEASLAQHSAAKESADKIAAELAELKAENEKKEADHAAQLGAASEAHEKVSSELLNAKEMLGSTFEQLATTKGEYDQLKKELDEAADSHKKTSTELGEIKAAHEKLTAELEEAKKTATADLEAANASLAKVKEELASKTAQHEGSTKELAEKTAQFDKASEEIAALRDGASVAESIKAELEEHKSLLEKEKAERAKLSEEHAVVVTRAETLTSDLAASKKAHETEAEAHVETKAELEKQRERLAELEKELATARAEVAAEKTKFAEQTATLEAQRKSAEEAEAQVKSLKDAASSNADEMSSKLAEVSSKLDASTKAAEEAAAALKSSQDEHAAATAALEAEKKARDTADKELVEVKAQHMSAAGDLVANLTALKKELEEARGQLSSKTEELDGVATQLTAAKAALSKIEKEGAAQLRALQGELDAAKGDVNAQRSRADKLAQQLLEKACTSPSKVAASSSRSLRRVSSVPSGLSASALGALRGTGDMSTPDVEGWKRSHATEELQRLDKVVVQQKAIIEEQRDKIRLWTDELQKQRDVVRLLSETSASSLPPIPGTPSKDSFEEPTTPSKYGQLSTPRKSQLPSTFTARNLALPSTPSLNAPSPLPMHTGQVSNALRKARRVTLERDMGRLQERAKVANMKNMFDSPSAAGGHGDDENNSPHTPVKTPSTKRRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMA7</accession>
    <name>K1VMA7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMA7"/>
    <dbReference type="FunCoup" id="K1VMA7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S73R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1262308_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMA7"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="219" mass="24197" checksum="32CFBB5842113E13" modified="2012-11-28" version="1">MPLPACQVPCQANVVDGGGRRAVPSGFSHCVLASVGFDHILSLLHPSLTHPSPSRPRAQRLPARHPFDCYEQSVPPPPSVPRSNVIMIFHLSALFFVVLVVALAWYFRIRLFSLAAPYLPSQLVARLSNYEPLQGYSFAEQREGGMSSSNFDLEENIGEGSGENRQGLDEAGVEEVRRIMAIERCTFDQARLIRHNRILAKNGIAPDGTPLDRKAITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMS1</accession>
    <name>K1VMS1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box/wd-repeat protein lin-23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000399">
        <property type="protein sequence ID" value="EKC98017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMS1"/>
    <dbReference type="STRING" id="1220162.K1VMS1"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_6_1"/>
    <dbReference type="InParanoid" id="K1VMS1"/>
    <dbReference type="OMA" id="IRAHTHK"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="410"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="491" mass="51271" checksum="5F9274DF3C3811F4" modified="2012-11-28" version="1">MRIPLSTGAEDLVSGLSAAWPSPARMSTSWPGPGSPAPSGQIVAGRDWLLSGSRDCTLRLWALGTRPRVVKIFSGGHTRSILTHFVTELPGPNGPKLMAISAGSDGRIVSWDLEGDGSPEKIVQAHSDSIFFMRGNAKYLVSCSKDRSIKLFSLADLSCLLTIGPEVEGAHRGAINAVSLTDELIVSASGDKSIKAWDIKTGRLVASCEAHSRGISSIGFEPAGSGGGSELAAGWKQTIKGSTLKGTLVTGSSDSTIKTFFLVEVPASYEEEVSFEDMMADPSNFPPGVHPSFFSTSANPAATYSHPAVQANLSHRSGPSGSGGSSGANGGGSAAGGRGESDGSVGSVGPGAENGEEGDGEHMEGVEGFVGPDEEGRRVIFEPGPEYWARCACALPMTPPNAHGCLRCNNRGHTDLVRSLHVAEDVTLSASYDSTTKIWDRVSGRLIFDFEGCHSGRVFAITGDRMRVVSSGLDARIAIIDFSQGLDTAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNI5</accession>
    <name>K1VNI5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_07481</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNI5"/>
    <dbReference type="FunCoup" id="K1VNI5">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNI5"/>
    <dbReference type="eggNOG" id="KOG1078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
    <dbReference type="InParanoid" id="K1VNI5"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="18"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="656"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="807"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKC98227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="920" mass="100779" checksum="DC681ACEF4223B3E" modified="2012-11-28" version="1">MSFKKDEDSGGMSFLQDKSTVLQEARVFNESPISPRKCRALLTRIVYLLYVGETFNTHEATTLFFGVTKLFQNKDAALRQMVYLVIKELSTVAEDVIMVTSSIMKDMQPNLEVVYRPNAIRALARIIDAQSVQSVERFFKSALVDRSPPVSSASLVSSYHLFPIASAIIKRWSNETQEAVNAKAVSSSSYSASSAAAYISGGGSNGYQSVSSSSYIMQYHALGLLYLIREKDRMAVTKMVQQFGAGKQATVVRNPMAICMLVRFARKVMDEDPNVQKQMHEYLEGLLRHKSDMVNIEAARAICEMRGVTDQDLYRPVAVLQLFLSSPKAVLKFAAVKTLSKLAQTHPNAVASCNLDMENLITDSNRSIATYAITTLLKTGNEASVDRLMKQISSFMTDITDEFKVIVVDAIRSLCLKFPAKQGVMLTFLSGVLRDEGGYEFKHAVVEAIFDMIKYIQDSREAALAHLCEFIEDCEFTKLSVRILHLLGIEGPKTRNPTKYIRYIYNRVVLENAVVRAAAVSALAKFGASVDDEHVTKSIDVLLRRCLDDVDDEVRDRAAMYLKVLDDKKLADTYVRDEATFSLAQLESQLVSYINDESKHGEAFDASSVPKVSREQAAAEVASARPSALATIADTSAAPQKSESPAPVSAAEAQSAYAAQLAEIPELASYGQVLKSSSKPIPLTEDETEYAVTVVKHIFKEHVVFQFNVSNTIPDTVLEQVSVILVPAEESGLTEDFIIPVPSLTTQTGAGAVYVSFTRDDPSEYATGAYSCTLKFISKEVDPSSGEPEEEGYDDEYQVEDVELGAGDYITPTYATFSSEWDKLANGPSITETFALSSSESLRDAVKSLVEVLNMEPLGGTEQPTSSSVHTLNMSGLVCGGGGKVLARCRMTFSPGEGVTLELAVRAEKEEAVNLVMSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP40</accession>
    <name>K1VP40_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP40"/>
    <dbReference type="STRING" id="1220162.K1VP40"/>
    <dbReference type="eggNOG" id="ENOG502RBHK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726009_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP40"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="381" mass="41502" checksum="E1BEDDD031E75BC5" modified="2012-11-28" version="1">MAYPYDDSDPFAQPDAHFPPPPYGQIQGEPLPLFPYGYPPMVGGLITNPGGAATTEDAGSTGSGEAPSAPQPQPMHHLQEMFGMPPEESSEGPLAEVASVIQSWYGVNVTNFDPSQSQPEYASWGPSSSAANHSQQTRAAPAPPPLQQPHATPTERKDEAERDSDPLSYLNGLAKSDYAPFAHVPSEDTLSGAAAWRLTVDPFPFSSGLEGAAGLQLQPTQVSMSGMRPDVLAKHAKDVEELQSYLEELISLMTPFAFTPTNPAPPPPPPYLHTRIARFAALIRDKLEQLEASSQSSLDPGFLDLPPHKDGGMSQAEKDMEFIRRRRDVLNAKARRDAQVAYVRPAFFPQAQRILPLPRCRACGGNMRGDVCENCYRRRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP58</accession>
    <name>K1VP58_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07229</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP58"/>
    <dbReference type="FunCoup" id="K1VP58">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP58"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP58"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="661"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="806"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="939" mass="104170" checksum="7ABDB0816F3F46CF" modified="2012-11-28" version="1">MDPSATCYTVIHDDLIDAPSSQDLRNALQKGSDEVKLETMRRIIVGTLNAFPPHANHSICPAVAQQADQEAPALLLGLKQEMILVCNAIRNDLQHPNEYIRGATLRFLQKVREAELLEPLVPTVRQCLEHRHSFVRKNAVMSVWTIYQDHEHLIPDAPELLDTFLAAESDSTCKRNAFTALCHISQPTAVRYLLSQADQVSGMDEIMQMAVIELIRKDARGEGGHKAKWIRLIFELLNSPSHAVKYEAATTLTSLTQNPAAIKAAGAAFAELIVKEADNNVKLIVLDRFDALRSKHEHVLDGMVMDILKVLNSPDMEVKRKAVGIALQMVTSRNVEDVVLFLKKQLQSTLDQDFDKNVEYRQLLIQSIHSCAIKFSEVAANVVYVLMDFLGDSNNPSAVDVISFVREVVEKFPDLRPTITEKLVQTFSEIKSGKVFRGAMWIVGEYCTGAADIKRAIFELRKVIGEVPILASEQRLLDEAEAADEAAQAEKEPEQPQAVTKTRVLADGTYATETVYTSTAATARLEQVRAAAKPPLRALILGGDYFTATVLASTLTKLVLRFQELHSDAQAFNQLRAEAILIMTSIIRVGQSKFVSVPIDEDSQERIMNCIESLAQLQDSKPVHEMFLKDTQAAYAKMLAAEEKKAKAKKDLENKKSQVQADDLIQFSLLQTKNLDGDDDDLDVDVVRATGATEVKDDFVSKLARIVQLTGFSDPVYAEAVVNIQQFDIMLDVLIVNQTNETLQNLTIEFATLGDLKLVERPAPHTLGPHGFHNIKATIKVSSTETGVIFGNIVYDKQGASDASVNIVLNDVHVDIMDYIKPAYCNEAQFRSMWTEFEWENKVNVNTQISDLRTYLDHIMKSTNMACLTPEAALSGNCDFLSANLCARSLFGEDALANLSIEKTEDGSIQGHVRIRSKTQGIALSLGDRITILQKTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPS0</accession>
    <name>K1VPS0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPS0"/>
    <dbReference type="HOGENOM" id="CLU_447724_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPS0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="610" mass="69194" checksum="8B68266D84CD3506" modified="2012-11-28" version="1">MSVVNFFPQAIATAQFLENPSPKVAMPVDPELFARSRIELSTDPDKRFQSKEQIAAYAVFIERIMARVRETRSHKLGSDDDRLAFFRGNLNSIISRRGCTEFESVSVCERYASKAWALNLHPPNTTAELLDWCSARIEAILAFETAPSTSCAVFPFVFPKLFTFASPEYKKYKTKAKWSQYFYGSDGRRMRLLAHDLPGEEDREAGLPLLARWAPLLLRKPENTFQFLPLTPHIGLLVCNNEFDEDVARKLYGVFTNCRVRLNDPRMPIVEEKVWGFPESGITRFLNGLTVLFLACSYIQDHVACSKLLHMPVVGLGILSDMDRNKLGHLCAKPFRQQIKAMLECMYLRRHKSISSMTAWGQRLSLLASIHVGRLGGPLDLWKELEYTSPLLLDLWQLCPEGFDTIPKRFEAAIMGFFAGNALGTLLQHISRQPLLSQRRAEKQKRAVALGTETVQNAVSVVQTAASMAGQAVPTAFSLEETKAALQYWIDSKLSEETETAKGICARILDEFYEHLQGFGVRLASAPVDFSPFHTQFQQSFMMTMETDPTKDYSRNLQYPRAIKEYKIIEVCPSKDHKNLTPDVWRKLFGMRLSPLPLDDEHPNKDLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ07</accession>
    <name>K1VQ07_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALA1</name>
        <name evidence="15" type="ORF">A1Q2_06885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ07"/>
    <dbReference type="FunCoup" id="K1VQ07">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQ07"/>
    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="InParanoid" id="K1VQ07"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="14">
        <location>
            <begin position="147"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="862"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="866"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121023" checksum="0C7BE80FEC115078" modified="2012-11-28" version="1">MSRRESKPTVPTTAAAKWPSPEDWPAAKVRSTFIDYQGVHVADLIMFWVATSHLSPPFWSCLNTPSPFLLLSLDPPKTSTPRGCSISEGCMLFARTVRPLSISSQHLHRTTPFTLRSFAPAGNMSRRESKPTVPTTAAAKWPSPEDWPAAKVRSTFIDYFVNQPGFEHTFWPSSGSIPFDDDTLLFANAGMNQYKPLFLGTADPKSDLAKLSRAVNSQKCIRAGGKHNDLDDVGKDSYHHTFFEMLGNWSFGDYFKLGALTMAWDLLTRVYGLPKDRLYVTYFEGDAAQGLEPDLEAKKIWQDLGVPESHILPGNAKDNFWEMGATGPCGPCSEIHFDRIGGREAAHLVNMDDPDVLEIWNNVFIQYNRENDGSLRPLPATHIDTGMGFERLVSVLHNVSSNYDTDVFTPIFKRIQELTGARPYEGKLGADDKDGIDTAYRVIADHIRTLTIAISDGGVPDKDGRGYVLRRILRRGVRYANSKFGAEMGTFFSSLVDTTVETLKEIFPEVTKKIPELKEILDEEEQSFARTLKRGEILFNKYAEAAAAGDKTLAGRDTWRLYDTYGFPVDLTQIMAEERGLKIDEEAFEKARLESLEASKAGGKKGAAGGVKFDVHDLGALEANDAVPKTDDDFKYKKGDISAAIKAIYHQSKFYESTKDVPEGEPFGILLDKTNFYAESGGQEYDTGVIAIDGQAEFKVEDVQVYNGYVLHVGRLEEGELKLNDEVICTIDELRRWPIRNNHTGTHILNFALRDVLGDGIDQKGSLVAPTKLRFDFSHNKAISPADLKKIEDLCNAEIKKALAVYSKELPLATAQKIPGLRAVFGERYPDPVRVVSIGFPLEDIEKNIEDPKWATTSIEFCGGTHVAKTDDIKDFVIVEESSIAKGIRRMVAVTGHEAADVQRKSAEFGRKLDRIANMEPKEREAALKPIPQELGQSGISVLNKLAHQERYNKLTAELAAAAKAQTAAAQKVVTDDIKQYFAEHPNENVYVASFPSAQGNSKILSAAQTAAKAAKKAVYAFSVDEAGGKVAHLNFLPKDEVSKAFNAKTWLQDVSKIITGKGGGKDETATGVGMNVDKLDAAMDEAKKAYLASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR33</accession>
    <name>K1VR33_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR33"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463953_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR33"/>
    <dbReference type="OMA" id="TFALICH"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="63317" checksum="1267F16BE7578851" modified="2012-11-28" version="1">MDSAPPRPSRSWRTPSVLWMYALAAGVTASVVMPAASQREEMIRLTCLVVGPAPPDSPSSSTEASDHGGQLLATALSLKPTLTLDMDLEACKRNVDVQQLLARINMVSQTAGGILGALTVAAWSSFSDRAGRCRVLAFAVLGLTVKELCFYIVLLYPQSMVSTGGAVLYAGPIFDGLFGGTPLLNAVWTAYLADVVPVDRIPINAVGLNAVAAVVAMVFPLVGPFLVKHTSSRYVHRQAPLNARLLPFEATLVLQVLLTLFVTFVVPESLRNAPERKHTAAPFQLTSVPPPGRQGFAVDVARRSMRRLFSPLRSLAVFLPRSRGPGFPKDWNMLCLATVFFLISLAREESPEVQYVMFTFGWGQSELARRYSLLALWRMATVATIIPFYTFVLKPFVVSRFSGAPRGRPCDDRGNTSEQSPLLAGLNEADGAMVPPAVPNSTEQGNQDPRPAKVKALLDQSFLALFILIECLGFTVRGLNVSGNVLQYVAGTAVALMGEPGTFILDPLLLELSPTAGKTGCLFGARTVLTTLGGSIFSPVLFNAILRATIGPYPPMFFLAAALLYFLSFLSTVLIRVRSIGSQAITQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS22</accession>
    <name>K1VS22_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS22"/>
    <dbReference type="HOGENOM" id="CLU_1788174_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS22"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="145" mass="16640" checksum="E227577362D1900E" modified="2012-11-28" version="1">MTPRIRLGLNSKPWHDYSDIKAYNEEFFSPEFQSRFPDGKLPLCSSIPEGQWIYRDCSTNDEWVIYAAATPPYNAILCEKVWANEDVDPHGSVLADTEYYVADHHFEPVENAQEIRDSLPPDATLQDAMQALFRTCKGCAKYVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS47</accession>
    <name>K1VS47_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-dienoyl-CoA reductase (NADPH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS47"/>
    <dbReference type="STRING" id="1220162.K1VS47"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="K1VS47"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="329" mass="34373" checksum="67768F3BABAE1348" modified="2012-11-28" version="1">MTDDSKQKDQATRAAVLTSVEERSQDTTGTGRVRGKVCIVTGVGPAAGIGAQAARLLAREGAAALYLLDVSRDLPAFAKSLQSTFPNTKITAITGDAADDAVVSSAVQRALDETGRLDVYFANAGISHLKPKAEEGGPPQLILDVISGTRTAQDISAAEFSEVMRINALSVFLALKYAVPAMQRTSEDKKIPQGSVISTASVAGVNANGGPLPYSATKAAVINMTKSAAYEVAGKNVRINCICPGLIRTDMTKTIFELAAMAGVDENVGQLNPLQRHGLPEEIGQAVLWLASDESSYVNGHALVVDGGLTASMPYIPGASDKIKELAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSE9</accession>
    <name>K1VSE9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSE9"/>
    <dbReference type="STRING" id="1220162.K1VSE9"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005386_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSE9"/>
    <dbReference type="OMA" id="ERTKYWK"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="625"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="2">
        <location>
            <begin position="902"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1147" mass="131630" checksum="545FE6AF8CBF7FFC" modified="2012-11-28" version="1">MSAKRLQSKLFGTHASPTLQGEDDRSGASTPVPPGVATPTELKIDIPPPGSSTAGKVGKDLSALPRIAHDTSESRDRWLCLDPICSCVVSTSEADPPSLPKRASAPKDDEKTPPAERGASPRPTSGSDPATPRERKPLRDRLLDSLGSRYRSVEAYRLEQSDKYEVHWKRWGPYLSERQWGTVREDYSANGDAWNSFPFSMSKSRAYRWGEDGIAGISDNHQRLCFSLALWNGKDDILKERLYGLTGEQGNHGEDVKEIYYYLDSSPTHSYMKTLYKYPQAKFPYEKLLEENRNRSREVSEYEIIDTGVFDEDRYWDVFTEYAKDEEDPNSISVRITAYNRGPDPADLHILPQLFFRNTWSWPKELPENMPNMREVAEGVIEADHESLGTTRLYCMPSPAPAAPTKGGVVLVDGPSVVPDLLFTENETNYERLYGGHNRTPFNKDAFHDYIIPWHRPEVKSEKKENEDGEKIETEEVKRYPANHFVNPAHRGTKAAAHYSFKNVPGKGGCVVVRLKLTPNSPAEDPAILDEELFDDTIEDRRLDCDEFYSHLGRGPLNEDLRSIMRQALAGMLWTKQYYQYIQKEWIEGDPGQPPPPPERRRVRNADWRHLYINDILSMPDKWEYPWFATWDTAFHCIPLAMVDPGFAKKQLDLLTREWYMKPDGALPAYEWNFSDVNPPVHAWATFRVFKIERQWHGVEDLNFLERVFQKLLINFTWWVNRKDADGNNVFEGGFLGLDNIGPFNRSEPLPGGGVLRQADGTSWMGFYCLNMLSIALELAKHNPTYEDIASKFFEHFLYIADAMTYPASDDQQLSLWNDEDGFYYDAIQWGYGHAEQIRVRSMVGLMPLYATLVLEPQVLNRFPGFRKRLDWFVENRPDISQRNIASLKKRGKGDRLLLAFADKERLKRILEKMLAEDEFLSEFGIRSLSYYHHDHPFNMRVDGQDFGVEYWPGDSKSGMFGGNSNWRGPIWLAVNFLLIESLQRFHQYYGDSFQVECPVGSGDYMNLAGCAEEIQHRIIHIFSRDEAGRRAVNGGNPKFNKDPYFRDYVHFFEFFHGNDGRGLGASHQTGWTGLVAWSIHKTGEFCRLPKTPKTPRSRELPMLSHKLTTVARHYFDDQINTPSVDGSLYSAYTDASTWDEPEPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTJ1</accession>
    <name>K1VTJ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTJ1"/>
    <dbReference type="HOGENOM" id="CLU_326023_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTJ1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="884" mass="97853" checksum="0346D5158DD73793" modified="2012-11-28" version="1">MASTTPQSLCYPDFPWDSIGEELVDWFQGLQPCMCQPLDTYLRGLSFIDLSNIVQEYRTTGIAPSRTCGCSGQKTTTSTPRPVAPPSATCRLLPEGSKKRWPHDVDPAQPEALDWVMRRMQERDVEASMKQSWVDHPKQWWRSAAFIPSAQFPRKRDRLLPGNGNKTVFGPCQQRTGAIKTLLVLNSYDSPPRPPPPAANNLWLSYLDRTCTPSSRSSAQPPLTPVVGVMVSEPQFTDSQAKALLAPYWACDVQLLPATSWDEATFTVPIATKASDPISFRNIQGVTVLFLACYVIGDDDSLNKLLQMRQTGSAILKDLIHNGLSSILDDRVYSCTKSLIRTAMQEKTDWNLEALCCQLSLWFDVWTNRKKTALLHAVYPLQIEELVEDLFGLWRERPFEGRRVFSPDTAGGWEDAAEVTLLGAYYGSAVGTIVLIALGRIEAGKSRIAKRESRVRLGTEWSTNCQSILCAVLNKSVSIKTDATSEALLDRINSRIVKANKQEILNIRSALDRVKAKLCTVTQSFNSFMDGQRLTCAFQQAFTSVVTQNIPIEPETVHAFFGGDVAEVSIATLRSGSPDRYNADFSHLIFEDLESRLFASRTDKELAEYIRMKNRPKTSVPPSPRLNPMPIVQKIEERKRVQKLREAERSAEQRAMITARSTKLALPASEAVTTTPPSPTHSNGVPLTCSSDVSSSTQKKMDQGQGLKAPKWPLVVAGLAAIVGICAAYYKPKFATSAFDRLHSPLPDLSGTVPPGSSSKVVMARVTDIWEFADKLHVSAGDMVELVGKPADGWYSIKVSSVDKPGVRSDDWHSLPARDARFKAWLAKCGVQDMQGAARPCLWRQSSRRAESPERALDNEMRTLISGAEGLRGTQGRKIAQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTZ3</accession>
    <name>K1VTZ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar ATP synthase subunit e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTZ3"/>
    <dbReference type="FunCoup" id="K1VTZ3">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTZ3"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTZ3"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="27720" checksum="DF5B1B2643E349ED" modified="2012-11-28" version="1">MSRAGALDDSEIQSEMNKMVAFISQEARDKAREIQIKADEEFAIEKVSLLHRDIESGADVDPLLTFHDQSRIVNTGQDRPSGVSRHRRPVREEAQAGRGWMEDSTALNQSRLEVLRKREEHLQQLFDEAGKKVKALSDSDKYPEAMESLVLEDKDLVKKASDAAVKKYKDMSGRTSTVEYKDSLPDDSAGGVIGSSMQGRIKVDNTLAERVKILEEKMLPELREDLFGKNPNRKFYTVSIPSHLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU93</accession>
    <name>K1VU93_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU93"/>
    <dbReference type="STRING" id="1220162.K1VU93"/>
    <dbReference type="eggNOG" id="KOG4524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004955_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU93"/>
    <dbReference type="OMA" id="PHPKKPW"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="3">
        <location>
            <begin position="74"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="4">
        <location>
            <begin position="901"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1216" mass="130001" checksum="8B2AFAF9D7195F43" modified="2012-11-28" version="1">MSGRDLFGRPLPTGSMSGGGSDPPRPPQQPRPPPSSQPSSRAMTALDASADARLGAFRQLMSLSSQQPTSSSPHASLLARILQICETLPPQAFSPSLINYVLFPLTSILRQSDPSALPDNFLETAYNLLAFIITRWRSASGGMDVKAWEQLWRFVVASASPRVGKDRRGEELSQEAATAALNVLIALLRDPTDEMKTKIQDPRGLLPTLFQSITLGVDLSNPAPPNTTLQRASVHLLQVALPYVTKSNILASLLPGVVSAMAKAIVGGVKGDIGLDMASVVQDVLVRTLNDADLRDSGVLAPQYDDLADLAGAWNAQQEKDLGVEDYEIDIDMTDEERAELAQSTGASGTSAKAGESIGGPSAGAPNPFPPLNAKYLQYTGAQLQATVPPILSTLAGHQSPDARAGAASLASALLLRCRASLPRLVPHTLSTLLLLSTDEFDAVRDAAETELLSLLGPEAPDLENALVELLSGAINALPRLIRAGDEKRVDETARLIIALAHTTARSENRFNPIAAFLGPSGHVERWAFALLECLEFGRPRGWSAQEGGAARTAALGWGGGLTSRSLPLLTEAPSAADASDTGADAASGAQEGSGRAQGGGVPPEASFPNLQLRYVPSPRIASRLESMLSSLGAAGGEPALHSVSYFVSFARGNAVAAPARSTSAVWVADNLLSGIASTSTGTKAPKAVRKAARDVARALVELDEAEDEAYEEDEQDRAHADGTVLVPERKSGLQELTTLLDRPMANQSASEETARLDRRSQRCLLTCFSLRSVSTSASILGASFKPLLLHTLYPLLAALSHPADLVRTFAEVALAKVAYESGYASAQNMVLANADYVVNCVSQRLTYHRLDSQAPLVLIAMIRLVGAEIVPLVHDIVDEVFDALDAFHGYAALASALLAVLNALVETMANDPQAMETEEGRKRKEEDKADTERFLRPPNPESDFAKFGDCTPAWVGKERSRRQPGRSRGRRGREGAAARRGSAPDRGEELGTAILSKATYYLSHSSPFLRARVLALIASCVAVLSGRPAALLPEIDKAWPTIMLRLTDPEPYVVVEAVSLLRSLCEYVPSYISKRLADAWPTLRRLLVAQMEQDRRNDLATRGVVGRVDKFSASHRLYAALLGVAQFMVAAVPVKEGVVWDVCVSFRPFLDVRAEAELQDGARELYSALNERDGDLTWTVLSASIGSLEGDRGTWDYLRDPKGDLRANAMAVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUC6</accession>
    <name>K1VUC6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUC6"/>
    <dbReference type="HOGENOM" id="CLU_2814238_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUC6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852422" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="67" mass="7414" checksum="4A5B3378210B653E" modified="2012-11-28" version="1">MKFYAIVTALFAAIGLASAAPWGEDNEEVPRRNLNAIVPIPSLLWCTLQERVALSQAAWTEQKTDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUK4</accession>
    <name>K1VUK4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUK4"/>
    <dbReference type="HOGENOM" id="CLU_1563995_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUK4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="171" mass="18408" checksum="40FCE03867C82341" modified="2012-11-28" version="1">MPLNVLGLLRRPLSRTPSNASIDSAFSSTSSSSTHTCNCPSCPSSVFPSSSSSMPSMASHSSGLTHATHASTATSSTVDSTLSTDSNGSSGSGKSRSSARSAASSAKRKLRMLYRSKFPNVYYTDKAIVYVKPKRRTSKRSIGHPRPLVKKGRSTVVRYRTPTTEERREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVE7</accession>
    <name>K1VVE7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVE7"/>
    <dbReference type="FunCoup" id="K1VVE7">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVE7"/>
    <dbReference type="eggNOG" id="KOG2834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVE7"/>
    <dbReference type="OMA" id="KWSRTGR"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="234"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="641" mass="69222" checksum="563ED26C8D1BC7A7" modified="2012-11-28" version="1">MARITVDNSTPGEELAKLILDTIPKDEPQPDPATLSLSNQPGASGEKVGFDALRGRKVGDMGFSGASEPVQTQAQTTSGTTTAAPAASASTSGSEAKPTRQAASGVDLSKVVEPEVDQYWRTQDGKIERKRDAAFCRHGDKAMCDYCMPLEYHTENQIKHLSFNAHLRKLLAGRPPSAATSSSVDLPPLDPLSLSVITPCPSGSHPPFPEGICSKCQPSALTLQSQPFRMVDHVEFATPNLIDSILTAWRKTGNQRFAFLIGHYDRYDKVPMGVKAVVEAVWEPRQEGEVDGLTIEVPWSDEKQVAQVAEWCEKGLGVVGMIYTDLTPDPDDITKTLYKRHAQSFTASALEMLTSAKYQVLHPLATRASPTGQFSSRFVTCCLTATEDGNIDVIAWQASEHGEAMVKANAVEASVDPGTVRVRKPSDGEYIPEVFYSFKNEYGIQVKMPAKPTFPVEYLFVNSFPVENRPGLSDQSMELVVRELLRILRGADLEIGDVGTWPSRIREDVQRWLSDWHLVAFLAMHGPFSPKEAETLAHAATAHKHPEHKGALEELFRSGGWQTLLTIAESSGSAMDTNDRFSQMGIASPQRSGTGASTPATGGAGAAAAAEASGPKACPHCTFINEPGNTDCDVCGLPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVL0</accession>
    <name>K1VVL0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_01148</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVL0"/>
    <dbReference type="FunCoup" id="K1VVL0">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVL0"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="InParanoid" id="K1VVL0"/>
    <dbReference type="OMA" id="LCDADNI"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="45"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="509"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKD04576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="700" mass="75403" checksum="529133FF00112837" modified="2012-11-28" version="1">MFMLQLAARRRLPHFARTYATTSTPQTLVEKIVQKYAVDLPAGTKVSMTHDNTGPVISKFLSLDCSKLDNPRQPVYALDHDVQNKSETNIKKYKRIEAFAKEHGVDFYPAGRGIGHQIVVEEGYAWPGKMVVASDSHSNHYGGVGCLGTAIVRTDAAGIWATGKFWWQIPRVISVSLDGKLPQGVTGKDVIVALAGLFNEDQVLNAAIEFTGDGIKHLAIDERLTIANMTTEWGAVAGVFPVDEKLIDWYRGQIRKAELRKFSSPSIPSTQNTDVHPRMNESRLQKSLQEQLSADPGAHYASRLSLDLSTLVPHISGPNSVKVATALPKFLEEPVKINKAYLVSCTNSRASDIAAAADVLRGKKIAPGVEFYIAAASSRVQQDAEAAGDWQALIDAGAKTLPAGCGPCIGLGVGLLEKGEVGISATNRNYKGRMGSPDALAYLASPAVVAASAAKGYICGPDSLDLNALPKYDVPRFAIEETPAQPVQPAETGAEPEPLLEGFPEYFEGQLVFAPQDNLTTDGMYPGKYTYQDDITPERQAEVVMENYDPDFAATIRGLRKDSPTPVLLSGYNFGTGSSREQAATAIKNAGMPLVICGSFGDIFKRNSINNGLICVEAPELIEDLTARFAQGGARGKGGKNGELTVIPEGWKVKVDTRRGGVTVTMGDEGEKYYPSARVGRSVQELWVNGGLEGFIRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVR4</accession>
    <name>K1VVR4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVR4"/>
    <dbReference type="FunCoup" id="K1VVR4">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVR4"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="InParanoid" id="K1VVR4"/>
    <dbReference type="OMA" id="RMIWGVV"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="63287" checksum="BDEA99793A1D6DC0" modified="2012-11-28" version="1">MGVPTPAETPVYDMGPASKLASGDLDASKTASTADPEGQEWLTKDDAALEGLGYRPELKRNFSSLETFGVAFSIMGVVPSIASTIFYNLPYGGPVGMVWGWFLSSILIMFIGLAMADLASSMPTSGGLYYWTYKLAPRKYAAFLSWMVGFPVLADSARYETTVLTSDNSFLGNVGATASVAWGCAGILLACGSVADETFAPSVGVTFGVYCGVLITCGFFCAYGTALFARLQTPLVILNTALALVTIIGLPIARRGHLNSAKFTFGGWENLYSWPNGFAFFLSMLAPVWTICSFDCAVSISEEAANASVAVPQAIVGSIGSAGILGTIILAIFALCMGPSVADVNDSAIGQPLAYIYMLGFGRNGTLAIWSFIAVSSYGMACSLLLPSSRQAFAFARDGALPFSRFLYKVDQRSGTPVRTVWLVVGCCIPLGLLGFADPVNQAAINAIFAIAILGPYVAYGIPIFARVVWGKHLFHPGPWYLGKWSIPVAIVACVWMVFALVLFCFPADMHPTAGTMNYAIVVSAAVWAFAIGFWYFPKIGGKTFFHGPRTEDLNDELIQAYAEGHVEDPGKTNGTTTVVQAVEEPEEEQQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWT0</accession>
    <name>K1VWT0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWT0"/>
    <dbReference type="HOGENOM" id="CLU_458695_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWT0"/>
    <dbReference type="OrthoDB" id="10629655at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="588" mass="64768" checksum="FFCFB1A08A1D79F3" modified="2012-11-28" version="1">MGYLKRHIEKKKEQQRKQDEERVPLERGLLYICDGWEADVFRSKKQWKDRVHRREQLAMELTQWMENEVVRDQGMISSWDLYADGLTTEIGENVQQEDPELADALKSNEDEEEMIQRLTRQALEFTQKMTTAQRDGGDIQGILQYEEKKAEKKVHDNLTAPTNILEVELQDQWLHAIAGRDTDAETGAACMGSATVATTAPLAAVASCPIIPFLFALLPLLKRPLASPGTFQLSVSSLHRCSPLCSAIELNLSALDTIATIELSVALSAARAMSTPSSSLYHQRFDPRLNPGTPSLFLSRSSAIVSQLTTDRSLLRRLFFIPSSAAQSTLERAGVPKSLAWKALRRMRTQHGAHAYAAAVAEYSQHASGIAWITRSAAVTEYQALCALRAFSDPAEARDHVLHQTHRVAWAGCRFCEREAAERQRRYSAISARSGMSGLKPIGEGGRSDGKAGRSAMDGYEQLSDYPPPCPPAIGITPATPIIPSRPLTPASRSSLSHSRSDMISKADVSKSDVGHGLKRTPSWTIKVQTLKRRNSAEAPAGAFNVVGVRYAPAQKEERTMAQHPPKDVVTGLGNSIGYLPQDIRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX01</accession>
    <name>K1VX01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX01"/>
    <dbReference type="FunCoup" id="K1VX01">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX01"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_14_1_1"/>
    <dbReference type="InParanoid" id="K1VX01"/>
    <dbReference type="OMA" id="RPFNEAY"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="383" mass="40444" checksum="5E668FA7B48F2C12" modified="2012-11-28" version="1">MGKDVKARNPGNIVVVGGGIVGVCTAYFLAISPHRPKGSTITLVEANAVACAASGNAGGFLARDWHPSETASLSAMSFDLHRKLAEQFNGSKQWGYRAVDTLSVTIDAEEKPSKAVRSSVPWLPAEHLHAVKVLGSKQTTAQVQPRALVRFLAERFLREPNCSLVLGTVIALSLQGGSPSSILISAQEGKGEDRILECDTVVLSPGPWLGRLARELLPSSSARSLACGGQKAHTMIIRTREPTTPHCLFIDLTLQDGSRSEPEVYPRADGTAVICGGSTETPLPASSHQVEPEQAQLDKLRSQANAISPTLRDGVVETECACYLPISDRGRPIIGKVKGVEGVYVGGGLSCWGITQGPGTGLVLSEMILEGKAKTADVSRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX36</accession>
    <name>K1VX36_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX36"/>
    <dbReference type="STRING" id="1220162.K1VX36"/>
    <dbReference type="eggNOG" id="ENOG502SC2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334685_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX36"/>
    <dbReference type="OrthoDB" id="2535907at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="853" mass="90578" checksum="03726C93598E99C3" modified="2012-11-28" version="1">MVDATTSPEEAETSRDGLRRMQRLTEASRRKVSGRSLAAFHPGSSYLIYPPSGRMGRHHVMTSVFTESAPRSIALPPIFSKSEMMSVSPDGAWLTSFFNNGPSENLGVPRIEERGDFMVFASSLLEPSSLQGGWPTLATMPLSSPPLAVLHVYPPRTKLSPSGQKAAPGLGPVPPPGHFTARSRGPSIVLLSTDLIYFLHPHPLPATVVLDTRSSHAVPTESVSAAESGNAAPLSWTLNALRCPLGIRSYASLNNPGPVTSSGTYRAERGWLGMVGGSDAVWAAVERDGEINVTRIDIGLDSNNMPYLATTPLPALPHAQPKPFDGATSPPHASLEEVAFVPLPDGDGSEGVGLSMIYRDVDMTFGPPPRVRMRFEYVELRKRSVAVVDGFKELGSGDDAAASQDWAPSVESKTTTVSPEGTSILAMTVLPDVPPHTLAMGLVSNNEGLFLSHINLAPHSENDTSAGGAPRWKALVGEQFALDPSVGNIDLALIPSQGVTRGEMGLVAVGGGGSRPRLIPSPRLGAPAHPEESLNHIAERCARSIELAVVQGVDWSDAVRAAFALVPRSEAGPLSAAILKQALNLFTKHSRSYVPHLLRIQVAVWAQADDGRRAYAAELIRLGEASQIFFLCGNEEGGVISFDLDSVWHLVDVFEWSVALLGQVFRDAVAEKASVEWNGADAEASGTSRVLYLVHPLLRRIVARLVALCAAFAKFVAQLDRPIRPPESAMMLTRCPQATAVAQTRVSDATATEGVDLNAWGEVLGSLSKLARPGDAEVCASLLGLDIAPLAPQLGPVLAALPAPSALFEAPAVQPERDGASFAQVGEMPTAVCDRGYLWGMANLQGVEVQVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX45</accession>
    <name>K1VX45_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX45"/>
    <dbReference type="FunCoup" id="K1VX45">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX45"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041093_1_0_1"/>
    <dbReference type="InParanoid" id="K1VX45"/>
    <dbReference type="OMA" id="GCTADIR"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854085" evidence="7">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="33"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="37145" checksum="36143D664EAC12CE" modified="2012-11-28" version="1">MLWGSLTAVVLGAISAAAAGAPSNIPEDMVDKRNHLRTHSLHLPYVDSDLQNRWWDFGEDTIVNTNRHMRLTQDRQSEKGWLWSRLPLSVSNWQMEVEFKVDGKASSMYGDGFAIWITEDRAVTGPVFGSKDNFKGLGIFFDTYANSRHSYSLPRVTAMLGDGHTSYDHNGDNAATELAGCSINFRRRDVPTKARMTYLAGKGFQLSLQTDKEGQWTTCFIKDIQLPPAPYIGFSAATGEVTDNHDIISVAAYSATLKYQYQDSKATAAVGGGGRQTAFQAASYNQNGGRAPPASSSGGVASWFLFLLKVIGVLAFVAFAVAAYRTYSAQQKKRPSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXU8</accession>
    <name>K1VXU8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXU8"/>
    <dbReference type="STRING" id="1220162.K1VXU8"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349907_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXU8"/>
    <dbReference type="OMA" id="GTQSIAW"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="235"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="805" mass="87258" checksum="9E038AFC4F0A21A3" modified="2012-11-28" version="1">MSRAPLGLCIQPACLEHKYIRHRDSSHIFERPERLRAVLLGFAAALARLESVDGPRAANGNGTTDDLSSMLSTLSLVNSVYSSDYLNVVPPPTPPTTPGNVLLHHPALQLAHSPPIEAPFPYLPRSKGAALPSSTYLRDLFKWASEAVEAIKNTGCEIPDDMGLNPGDLYLGPGSILAIEGAMVSAEIRRPQASSRRFPRRPPRTLLFRRSRKRFAPSDHLVTIAGKMRRLAYIQHDIDRAVIIDFDLHHGNGTQALVMPLNAATYAEDLAQKAGKPPPMESGKKGPRRGWKGFYGSVHDIYSYPCEDGDLDLIRDASVNLAGHGQYIQNIHLQPYASEEDFYERIYPLYLALLEKALVFMKETDADPERTMLFISAGFDACEHEHQGMQRHDRRVPVSFYSRYTRDIAVFADKHLNGRVVSVLEGGYGDRALTSAAMGHAIGLLDRQGQADWWSVEQLMLLERAVKKRRKGKLCALPPDLAADPVLARTHAILAQFEGTMPASPAPSAAPSTQATPRMTLRERKPKTMYSDSPPQETRRRPRAVKEEPSPSKSKEVAKEESAKAEGAYPSPVSSAGSPPAAEQPEPRIVLKIPRVTTPAAPGTPVASTLVATGAESAAPSPIPTHSLRSPMPPRQQSEKAASAGAPATPPLEAALFRPEQPQQPPAVPRVQAQLAAARPASFTYSPPQSSDPSIPTNSLQSPPVVTTAFAPSFPDSFRPSQLTAPDLPPTPVRPGRPAQPAVMPAVIPSGPSFHAMPSLSSMMVGDPSLRVPKEPEPDCAYRVGAPGQPPSVPRTPKGVVEKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXY9</accession>
    <name>K1VXY9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXY9"/>
    <dbReference type="HOGENOM" id="CLU_272392_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXY9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1186" mass="133018" checksum="712A09084E5054F3" modified="2012-11-28" version="1">MTPEQKRELQRRERDERAERRASERSVHFTPPDKAAPPPGREMPCQFPARSPERTPGNQPEAAATANTTSAPQTPQRSQSTNASPADSPMDVDTPSYAGRFTGVPNLVLPPGPQVLRGLRRLRHWCTPGFLAPPGAEYKWDEETSEGGDEDEDDEDDGDDESEESEPALPPPEASYRAPRSEAGDSIYSDTTSVAESWVPHWNFTRRLRGFLLSRSDVWLGLLCFIVCLIPLTALGAATWYYWPLIWSVLLDRWQQVFFALLLLIPFVWAAHVRWNRCAHGLSNRHKYCRACATCHDLWDDKCTYIDKAVEAQQSPPQLFVHGPEGDMHWADAEIQATRRAQEAAERYRMKKQEEQQRREAESVKGLINRPIDFSGHKTFSELLAIAAWGILGTAWFVAKWGVPLAIVGWYLWAYVLPSRECACPSPATFCEVRSDLSSRRKSYATSTEIELTSTSPSLLLSSSSSRPISTTTAMARAPPIDALKFLSSRRRAIVAEAPPELREVYAWVLLAKRQSTFRSRNPACRKCTKRGWPCIDPVQPGKQRRCEGCYRSGSRCVMPHPGEVSAASTPRRSILETFGGESDDDIMDVDDEIEDDLDDLQEEGGVMVVDPDAEAEQFFTAVNEQESDSDSEIEFVSMTGPGPAPWVPPTRASQTSSRSRSQATQSATSASQPIVQPPIQPISQPVTNPTPPPTPPPSRPQPHQLQDLRWSDTDVEAILDAAGRHADASSVLLYNGEVKSLRGKTLLVVVIPAQGGMPWHVALCERTGKKARLICESNHDQKSMTDHALALFRAMGCRIDNFGAITLDRLGVPGPVWTSIAAIWLTRKGRRPLPQLTQLSIREEYVLRDINCLLRVGYWQGQCTVFRPVFRPTQPPPRVDAVQEPKETDSLLQPQQVTPSTTAGPTTRQQSIEPEIKPEYVNDDSESEASEQPGERTSYYGIDFSDEGVGKLLKGASETADKKCLIIYDNEKKFLQGAEQVILVFPPRNGLPWHLGVCHRPSQKTRLICPVREADPEVMLAHIKERFLAFPSLRCDMSDLAAVELPRRLGKVPVGGWAAIIAIWLSRGNSVDKLADSPRIRKKLMRKDLNLILEGNQWADKCFRTGYKERRRTRAVEKVKEEMKEEARRDHAKSSSRRRRRRGDSDRQRQRHATADSEERALNAEPCPRTPVFRTHAKQPITIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYS0</accession>
    <name>K1VYS0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000305">
        <property type="protein sequence ID" value="EKD01928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYS0"/>
    <dbReference type="STRING" id="1220162.K1VYS0"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_14_2_1"/>
    <dbReference type="InParanoid" id="K1VYS0"/>
    <dbReference type="OMA" id="FTCWDLG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="176" mass="18975" checksum="26583D6B4281EAFD" modified="2012-11-28" version="1">MGAVVASAPTVGSNSEIYDYKGVRFGLVDLGGQSSLRSAWSQYFADTAAIILVIDSNDSARLGLAKAELQKLVKNEVSRGRRADAERSEARREAFKASADMATIRDAELKSALLLVLANKQDLPEQAGRLTPAQVSEGLGLTDLREREWQIMGCSALTGDGLMEGMDWLVNKLTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ31</accession>
    <name>K1VZ31_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ31"/>
    <dbReference type="HOGENOM" id="CLU_1497259_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ31"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="180" mass="19197" checksum="03003E3C7BCDEB57" modified="2012-11-28" version="1">MHEGYLVGIWRFRNVYVGFVIMSAGRGQGDWRKPGTGGMFVIGWGRVQVAQVVVRALGGLLAWVSGGIPSFPPRALSKIQRFTTASFLTPLTFPSPSNTDYNTTMSVSSGEDTAPANSSPSTPEMRLTVPNPARKTKRRIAVLTSGGDSAGMNAAGKSTNIPWALNIQRTVVAPGCLVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZS0</accession>
    <name>K1VZS0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000293">
        <property type="protein sequence ID" value="EKD02303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZS0"/>
    <dbReference type="FunCoup" id="K1VZS0">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZS0"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_10_0_1"/>
    <dbReference type="InParanoid" id="K1VZS0"/>
    <dbReference type="OMA" id="ESMHART"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="84"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="318" mass="34488" checksum="09EE08FB24E1059C" modified="2012-11-28" version="1">MGIGWILKPLAVASAVAFSTLGVLSRSSQRARLYFNATIFIATLGAASAWGVVISVLASLTGQVEGEEHIKKLLTANNGKPQSAVIIGNHQSAFDILYLGKILPKRSSIMAKKELKWSPVLGQFMWLSGAVFIDRKNRKNALKTVQQAGDQMKKNGVSLWIFPEGTRASHAEPALLPFKKGAFHLAVQAQIPIVPVVCENYHHLFDGRTRLDPGNLKVKVLPPIPTKGLTADDVNELLEKTREQMLSTLREISTSAKAIEAPADEVVEEKFRPEAIIDSAPEKLLEPEAKASSPSTTEDEMEGDAVLLKRPNAGAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZZ5</accession>
    <name>K1VZZ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZZ5"/>
    <dbReference type="STRING" id="1220162.K1VZZ5"/>
    <dbReference type="eggNOG" id="ENOG502S1CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033260_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZZ5"/>
    <dbReference type="OMA" id="SIHYVFR"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="349" mass="38356" checksum="FC81A49BFDF7BA9A" modified="2012-11-28" version="1">MSASPSSNPADHAPPISSDHVESGQPEEYISMTQFRKSMQLVRLQIAIPISVLVSLGTAMVCTLAIHPGVKEISDQHPTLLTPNDTMTGAYWFVVYFLQIGFCLVLICARSDATKATLIHGVGMRYAIANWLIALAVALWTLQLFRSCALVVIVNTLNVISIHITLTKYPPSLKHPFDAIFIHGGVALLTAMLFELTWLHVGSVAMGWVIESKKHWAHYRWESTIAIAVVNVITAIWEAATNQHILPLASEYVALCLLLSSPRINPSMPDSGLPKPASEVITLICCLVLHPLAVVASYGIRRQRNQEGRIRLEEEVEEAEARAQQAQERAAAARRRAQQAGVDTDNGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1W071</accession>
    <name>K1W071_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W071"/>
    <dbReference type="FunCoup" id="K1W071">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W071"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="InParanoid" id="K1W071"/>
    <dbReference type="OMA" id="NVPMTLN"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="60"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="385" mass="42155" checksum="0148C4F63F272A3E" modified="2012-11-28" version="1">MPPHESSPLLGANGAPSVERMRFVHSTKYLLLGSWMNALLIAVPLSLYSEHADWPASYRFITSFLAIIPLAKLLGDATEQLSMKMGQTLGGLLNASFGNAVELIVAIVALTQNQLRLVQTSLLGSVLSNLLLVLGMSFFASGFYFHESTFQVTAAQTNHLSNKTGGWFDGAGKSTPSDDPSLPGLLTLSRGTAVLLLLTYLAYLVFQLRTHANLFEAEEDEEETPTMDKWSSAIWLCIVTVVTAFSADVLVYRSHPSPSCEQLVRCVIDVQVGNAAEHVTSVWMACKGKMELTIGVAVGSSIQIAAGMIPLLVIIAWPMNKDLTLDFTTFETIVLFVSVMLVNLLLQDGAYFRFRLFNLADRVFPPLSSSSYTSRPHELPRRCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W139</accession>
    <name>K1W139_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W139"/>
    <dbReference type="FunCoup" id="K1W139">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W139"/>
    <dbReference type="eggNOG" id="ENOG502SCSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125052_0_0_1"/>
    <dbReference type="InParanoid" id="K1W139"/>
    <dbReference type="OMA" id="SRGMNRQ"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="112" mass="12625" checksum="10F1C3A7E7B52A0C" modified="2012-11-28" version="1">MAKSLRSKAKLAARKRKATESHYAVAEAARTARVSAKLLKKDENAMDAEGGEEEGDAEMKEERKISTSGPRESRREQWRVSKGMDARPKHKGQNHLGRPVSRTKAGRTKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W207</accession>
    <name>K1W207_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W207"/>
    <dbReference type="STRING" id="1220162.K1W207"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_2_0_1"/>
    <dbReference type="InParanoid" id="K1W207"/>
    <dbReference type="OMA" id="VECCMEV"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="166" mass="18158" checksum="9AC32712A6499A87" modified="2012-11-28" version="1">MDNDELNLEIIVNNKVTDKGQAVIQLETAIGAAIKHFSSAIGINVPRSRFLPVKSCSDLLLIKSSLYNLQHGVLSMDKSREFGGTPVVKLGDQFKKVANFEKRFKSIPNIKELDHLTVSGDVWFGKGVRLAGTCIIVATEGNKIMIPDGTNLENKLITGNLSIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4N0</accession>
    <name>K1W4N0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4N0"/>
    <dbReference type="HOGENOM" id="CLU_1628221_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4N0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854192" evidence="2">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="163" mass="16423" checksum="9F0FEF8D062867A7" modified="2012-11-28" version="1">MKFSCFTVLSLLASDSTGNTIASAEPVPANSSESVINNEPTEERPDAPAPPTEVLVNADVIEPESTEFEGTVAETNSSSETDKEVDIDDEKNMANGLSFGGGARGGSVGGSSGGSRGSSGSSWRGSSGRNSGGYYGGSSRSAAGRTELSFGVAVTGILFAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W530</accession>
    <name>K1W530_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_01697</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W530"/>
    <dbReference type="FunCoup" id="K1W530">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W530"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="InParanoid" id="K1W530"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="41"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="320"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD04023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="47861" checksum="5D70D9A1BD7F9CA5" modified="2012-11-28" version="1">MSAPVTLFGKEYPADGNTNTPPSIQAKVGRNLHLQKDHPLATLREIIETHFKGFTRIQPESPVVTVFQNFDELGFAPDHPGRSLTDSYYLNKEHMLRTHTSAHEVEAYKTGADAFLIAADVYRRDEIDSSHYPVFHQMEGMRHWDVTDVKQLTEQLRAENAKLAEELAACPIEITDISNVGPENPLQECHDPELATEMAQNLKHSLNGMIFKLFGHITADGQPLKVRWIDAFFPWTSPSFEVEVWYNDEWLEILGCGVVVQKTLERGGVGHKSGWAFGLGLERIAMVLFDIPDIRLFWSQDPRFLSQFKQGEITAFKPYSKYPPCYKDMSFWLPEETQEGIKPWHENDYCEVVRDVAGDLVENVTLIDDFTHPKTGKRSLCYRLNYRSMDRSLNNEEVNALQDKVVGRVVKEMGIEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W555</accession>
    <name>K1W555_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_01641</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000235">
        <property type="protein sequence ID" value="EKD04058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W555"/>
    <dbReference type="FunCoup" id="K1W555">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W555"/>
    <dbReference type="eggNOG" id="KOG3721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="InParanoid" id="K1W555"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000008">
        <property type="entry name" value="Probable NUC1-dna/rna non-specific nuclease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852636" description="Endonuclease" evidence="12">
        <location>
            <begin position="22"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="14">
        <location>
            <begin position="89"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="13">
        <location>
            <begin position="90"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD04058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="373" mass="41189" checksum="541A5515DED2262C" modified="2012-11-28" version="1">MPTLGPSILFVAGLTLGVGAGALFPRKKEQQVPVPVPVPAQSLPGNVPFPVPVERPGAGHEEKRLVVPLAGSTVTLAGGFPGPHFDIIRRQAYMAAYDRRLRHPAWTAEHLTAKSLSRPPPNFHGGPPVPADKARAADTAGPKADRQKSQFQEDMSVPEMFRAKLSDYFRSGYDRGHMVPAADAKISQDAMDETFFLTNIAPQVGEGFNRHYWAYVEDFCRRLTSNFEDVYVFTIPLYLPEQGKDGKWRVSYEVIGNPPSVAVPTHFAKVVLASRPDFSYPQTPNKHDKSVTSPETVKELAMGAFILPNKEIPDGADLRTFIAPVDKVEKAAGLQLFNDELKGKSRQLCAVTQCDVIVRRFDDARKNFNNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W612</accession>
    <name>K1W612_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W612"/>
    <dbReference type="HOGENOM" id="CLU_097661_0_0_1"/>
    <dbReference type="InParanoid" id="K1W612"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="27979" checksum="D303DBE737DEB65A" modified="2012-11-28" version="1">MSPSPPDPRGFPCAQRYTPDWPLPNFPRHIARWGARVGTHKWKAAAEIGDFEAMAAVLAPAVLDAALERMYDARKPKVPENGHGSEARQPHPERPGHRTFQDWIDLTTQIVREVYASALSSLPPEYQAQAPPVSRVGVLCRNTMNAEWSPSVDSSYYPCSYNRSRPIPLEELELAGCDPRSDANFPDVQEWVRVARGWAEPPPYELLVSAGPVEEIEVNEDEYEETLAELQREARILWRMVAAEPPTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W668</accession>
    <name>K1W668_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W668"/>
    <dbReference type="HOGENOM" id="CLU_496240_0_0_1"/>
    <dbReference type="InParanoid" id="K1W668"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="549" mass="60026" checksum="5D595D3A682E346D" modified="2012-11-28" version="1">MPDANLEYFPHIVDLIFRHIPAWDLHIASQVCSSWRSRAEAAYVRHLSAKPDGRVWELSIPADFFFSHELQYYLPFPAPRPRPRPRRTCPRLWRDDEPYTDHLRPLAPELLRHVQVLDVYFYDLEVAEEEKTYALFLDRFPNLSVMRAQARCNFPIRGRGRTQVFFAIWEECLDTRLCTSDAETVVLNFWGRTYNDVLDEGNPIQAFVSEQILLEGCVEVVFVLDKDMAEGGGAGGAGGAGGIAGGGGGVMPTRVTLVGFESGGQYFNTSLARNLGDDYRHANLALLSHAQYERRVGWETYELHCIWEMERWRPLQRDGLSLSVGCSLRSHAACAHSLAAQLAHNPLPRHIHVLVRDTLLPRRRELLASAVDAVGLLITINAISGRSLLNNFSRGGAVGRGFLGGSGGGGGRAEGVAVVPLRCDWGLEARHCLPSRRQQEPSHNYATAPAASEKAGSGEPEPQSHLSGTTATPSALPPATATSAEKPPTNGTAPAEVVEKTPAANGVDGDEKTNGVNGTGEKLTTTGKKGVSDEYVDMPRKGVMGKLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1W697</accession>
    <name>K1W697_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W697"/>
    <dbReference type="eggNOG" id="KOG1020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244949_0_0_1"/>
    <dbReference type="InParanoid" id="K1W697"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1585" mass="173733" checksum="52422CDF081D7F04" modified="2012-11-28" version="1">MQPNGTGPGQPNAQWGSGPYDDPANLLRVYPFATYTPTARASHFAPHTVAYSGPSNSANLYPQYSFNGTEYSPDAANRVASAMRSQNSYGGFNYQQQQQQSLYQPPTFPSTPQNGYGNGLTGGYRAPITPQQQQQQYQTPAQQQSTQSGQMYQGFQSSPQTQDLSSYQQSSQPYSVPNASLGQSSMSTYTQSQPSTTTPYSSSQFQQQFPSLSQTASAPQSQLPPGYLQSFQQPSQRQSATGVNASGQSIQSPLSLPQQQQQQKQDSFASPGFASQSPVQSAQTLQGQSYGRPSPALQTGVSSAAQQPFQRPVGRPTLPSPSVGTASPLQAFASAPLGAGSTSLLQDQQTQASPQLRRASYSLPFPGLLNGQQIQSPVQQAQPSPVQPPKASPLQPSPSGLYQGSPATQDYSTSSSTLPPPPSFVQSPIPQSSSQFQQPSLLPTQLQKSSFSTQNYQQSLQSPSLQSPVQQAAASPVLQQSSRQQQQGYPPIRQQQQFQQQQSQLPPPQLQHLLQQQQQRQQQNVQQQQQQQQQPTKPAPPQKQSSYDNFMPDFSPMGGRQSSQQPQQYQQPQQYQQPQQYQQPQVSPPLPPPQQPPQVKEPQPPSPVASSSSQPPAPPTFPMTMSPQGMHLPGSQQAKQFSMAQMAQGGRPQLPTLQTTPPLNQAPPKPTQRKKSAPQQQQPQPEPQQQPPPPSMPQPPVTPQQQRQGMPQYMQPQFQQYQQRSSIPYNFLPPSATGSVPPTPATLTGASPASSSISNTDYFENYVNRTLTFQSPKPAPNGAPAPAPSMPPPGVSPFLALPRPLPPPPSVVIPVPAKKKKKAHPKPVSQDSQPSPAKKAKTLDSRETATASPRSSQIYISVPKLSPAQKKSYQPAPGTNDEEEDDSIDWGTNGQVDQTPQRHRILSPDFDDIPVVGTGRTGDKDTRCEFIDCGFELTSAALDKLQNTLEDIFEESDTFDAEPSRESVSSSKYFDTLSRDGSHPLLAAATINNVTRRVTRVHKNQKRQRLESNRQAVAWDVENLSRLFRMLERVMNETDELEVFPNNGRKTVINGSPTKKGKKSKKVDDEPKDDTPDIQLTEDEVLQAEERLTTMSTAAAAALCVLVVLDSDGLPKQLYSEDLLSLAVTTIRDEMTKVLFPVIEGLAGESELQKSRHKLTTEMNSDYLAHLVTEESTALAKTKPSKKLLVSQFQNPILSAVAQSTCAAVPHIATLIGRPDMSFSDTLVIQTVYLAIGPVFVNEPSSKRGNKGGPSWSVMKSLRMEALGCLRGYEDQRQWIIEEILGSLGRGHEQGSRQTHFHSINTLSALLLQLIQASSHGVGDRIRKLRSSQFDYDAPDQQDVQMGQADAKAAAQESQESIIVTECRDLALRSTHMIALCGTGKSNKLTTDTDYKAILDTFVSDLLNALYRPEWPAASLFVNILSKIFVGALDEGKDKASHSSEANAARSIALDYLGDIGAKLRSFNNIMQEKRSVPSLDEVISDELVAELPSLLEAHSSIQNFLSSAAREDTMFVSSGELSRVLWSQELYQPVERLESLIQKYRMDNDDEAHQHRENLQAILKTIRKASHDVWTADEMLFEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6M5</accession>
    <name>K1W6M5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000411">
        <property type="protein sequence ID" value="EKC97443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6M5"/>
    <dbReference type="STRING" id="1220162.K1W6M5"/>
    <dbReference type="eggNOG" id="ENOG502S1F2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369261_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6M5"/>
    <dbReference type="OMA" id="RERNTNE"/>
    <dbReference type="OrthoDB" id="2528779at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="790" mass="87892" checksum="990CA9A448371687" modified="2012-11-28" version="1">MAPVKPSYSQPLGCKSPSLAFLPRADSPSNIPSQPLLTNHRLVAHPCSTLVAVASPRARCLDMFNPGAEPGPSKRRAPKTASGENKVSCTACRTVKCKCVEAADPSQDKCQRCERLNIACVYQAHQRGRRRKDGSRPHRRDEVSSPTSDATSPAILKRKYSDHGMGREGSQGHDVNRRRLSVTTGPSPATATPNGSAGMTPLRPSYQEPFPPDSREPHREVVDSKEHLRPSPDPDDHDHDHDYHRDIDHAPVNTVYHDVANRSIFSIAGVMDRKGGDDSPEYSTVQASNTKDDPVALGILTMAEVESLFGHYFDQLQTCVCLLDPAIHTARYTYRASLQLFLAVLTVASKFFRPELYDQLNVIANRLIDRAMSDCVCSIEIVQAICILHYWKKPQDGRGWLRLGHAIRLGYQLDLHLPRKDKLPADERKARLVIDRERTWISLFCFDSTQTELVDRPSMMMRAPDVGAWIREIPYPLPSDGQLDFAVKTSCLRLEVRQLQNCKGNYEILRSGLRRISEDLHRSHQILLSDEYPVKLTSTSVSINKFSTVAGQLLVECTSLSFAPKKHRISLMHACVSTSLDLLDIVVEGFVRKGIMPMIEDAHSVAVASTAVRLIRFLPYLDGSARAAVLRKMTKVVIVCREAARGDQESHPAYLARFIHALLDKAHQSRPPSRAPSPAAARQLHMTGMTPMDAPMPTPQQQKTTPDQWWDEIGQFAYNQEQPQLFKEHQDFWDGFPLLAGAMNTLTPAGQQNGVPPGTSPGGTIDPLAAPFAWDLDFLGIAQPHWATNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7E1</accession>
    <name>K1W7E1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7E1"/>
    <dbReference type="FunCoup" id="K1W7E1">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7E1"/>
    <dbReference type="eggNOG" id="ENOG502QRMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_0_1_1"/>
    <dbReference type="InParanoid" id="K1W7E1"/>
    <dbReference type="OMA" id="ATWNKRE"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42267" checksum="6AF95C15D8CC68B4" modified="2012-11-28" version="1">MQAQKHRTAVHIDPFKPAEGQKGLMNRWHPDIPAFCSVKPGEVFNVECHDWVGGQIGNNDSSDDIKIHNLSGPIAVEGAKTGDVLVVDILDVTPFPDMQWGYTGIFESIYATSRHIPGVRFAGIPHPGLIGTMPSQELLDKWNKREGELIAANEGCCPEVALPPTAKGAYVGQDLPDKVREKVYKEGARTIPGREHGGNVDIKNLSRGSRCYFPVYVDGANLAVGDLHFSQGDGELSFCGAIEMTSIIKDGVKKLGLRQPIFLPSPIDPKYHEQIIFQGVSVDVHGDGKQYSMDATVAYKQAALNCFDYLNRLGYSREQAYLLCSAAPVEAHVGAIVDVPNACVTMGLPRAIFDRDILPTEDGLEKRDYGQAAIRSDGVRCKQPNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8K0</accession>
    <name>K1W8K0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur protein required for ribosome biogenesis and translation initiation, Rli1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8K0"/>
    <dbReference type="FunCoup" id="K1W8K0">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8K0"/>
    <dbReference type="eggNOG" id="KOG0063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="InParanoid" id="K1W8K0"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="68"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="344"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="639" mass="71432" checksum="E4BDB9CF78057B94" modified="2012-11-28" version="1">MADKLTRIALVSDDKPKKCRQECKRSCPVVRMGRLCIEVTPSDKKAFISEELCIGCGICVKKCPFEAIQILNLPTNLETHVTHRYAANAFKLHRLPQPRPGQVLGLVGTNGIGKSTALKVLSGKLKPNLGKFDNPPEWTDIIKYFRGSELQNFFTKVLEDDIKAVTKPQYVDQIPRSIKIPNMTVGKMFDRQTELDNRKQLEEDLELAKLQDREVGQLSGGELQRFAIAIASVRKADIYMYDEPSSYLDIRQRLAAARVIRGLVQPTNYIVVVEHDLSTLDYLSDFVCVFYGVPGMYGVVTMPYSVREGINIFLDGVIPTENLRFREESLTFRIGESADEVAAPKTQSIAYPAMTKTLGNFKLQVESGEFSDSEIIVLLGENGMGKTTLVQLLGGKLKPDNEADQVSLRVSMKPQTISPKFPGTVRMLLLKRIKAMFMNPQFNNDVIKPMNLEPLMDQDVQTLSGGELQRVAICLVLGVPADVLLIDEPSAYLDSEQRIHASRVIKKFIMSTKRTAFIVEHDFIMATYLADRVIVFEGTPAVSAKANKPEGLLSGFNKFLKSLQVTFVPPNVAVEVEARWRPSVAAEPKFQSPPPTTPSYTSLTSQRRDPGNYRPRINKLGSLKDTEQKAANSFFFIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8P5</accession>
    <name>K1W8P5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000399">
        <property type="protein sequence ID" value="EKC98018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8P5"/>
    <dbReference type="FunCoup" id="K1W8P5">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8P5"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="K1W8P5"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="178"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="462" mass="51040" checksum="4D4A1353D67BB692" modified="2012-11-28" version="1">MASPTTSSLPRKRSPSPSLSPTSASAIHSADAAAATTASSTSGHAPVDRVEIKRRLVRAKKLRKPLNDDDNSDDAAAQAHPPSSDVGIGSGRHSTPHEHAPLPDTQAQPDSQEREGRGQDRQAQDQNDHATPTTAPSSIPPSPPPVTALTQGGFPRSEYAPRRQDHPGLHGCRSVYKYTRLNHIEEGTYGVVFRARCNETQRVYALKKLKLDDERHGFPITSLREINALMTAGDHENVVGVREVVVGDTLNQIFIVMPFIEHDLKTLLADMPAPFVQSEVKTIMLQLLSAVEFCHANWIIKVADFGLARKFGDPLGEMTQLVVTLWYRSPELLLGAKKYTTAVDMWSVGCIFAELLQKEPLFPGRGEIDQLNRLRQKFKHLSSEGHYLLSSLLCYDPERRISAEQAGKHAYFAEQPLPKHPDLFPSFPSVASGERRHKLLHSPPAPAHEEVDSEKIDLESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8T5</accession>
    <name>K1W8T5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8T5"/>
    <dbReference type="HOGENOM" id="CLU_496242_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8T5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="549" mass="61622" checksum="E8EA805039954BF5" modified="2012-11-28" version="1">MGLAMGLRLRLRAVWRGLRRGFPGTLRRRRHRSCPTCQASNPPLIGSPLTAPQSPPTSARGYKSLNNPETPTSPKFHLPESRSKQIRATLTLLEPKLGKAAAIPAKLRKRPPQPPPLTLPFSDNTSPPSSPTSTRVPSTRLPAASPFAQWHDKAESILALAVTPRLTPISEVSHLSLKQLPLKRSAPAQQPRLTDLPDDAQAARSQNACEQDEETVSARVRRLVQMERRHSSNTEETAHLFPPSTPFPPSRAWHRTSTRSSSSASGSEDSPFSDIYSESRLSARHQPNCAPPDFTPFNYWAVFARIASHTDWSTALALRQTSRVMREMVERSLPRELWIHGTEDAVDVGFFDAVPGNSAPIVRRRLPFFARDEDDAKGRQAGALWRATSVEISGLSSRVLNGHLRGLSPRASVLIRRLQGTRRNPLLLPQIESLIIDSFHMRSLRLHTRHEARKLYLVCPNPRFRERAGRRTAQLLNPSVRYLYIEIGGRRTAHAVAVLFDRLKETQLFPRLVYEMGHRGEIIEWESLLRGSLKSWWAGAAQQLRQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9N3</accession>
    <name>K1W9N3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase family 18 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9N3"/>
    <dbReference type="STRING" id="1220162.K1W9N3"/>
    <dbReference type="eggNOG" id="ENOG502R2HG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086735_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9N3"/>
    <dbReference type="OMA" id="CHADTEN"/>
    <dbReference type="OrthoDB" id="2560689at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="1">
        <location>
            <begin position="69"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="230" mass="26694" checksum="DCBE3F012F3C2492" modified="2012-11-28" version="1">MKPDISDTVVVPWEQRPNRVYLLAKYARYFQNGHQACIDLSFFERATEELRRDFPDFEFVGGFTDERNEEDRKKFDVPTSVRNLGKLNATQFDHEFGQAKLLLGMGSPTLSPSPYRALARGVPFFNPHQKREDGQPGFGFTQHDSLAPVPEPYVYNVEAFNYEEFVGAIRRALTTPIPPTRWRRMAHDVVDERLRDWVLHDWRGEAEQILNDRKAGIDTQHHEEAGDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9Y8</accession>
    <name>K1W9Y8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="4">DHBP synthase</shortName>
            <ecNumber evidence="4">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9Y8"/>
    <dbReference type="FunCoup" id="K1W9Y8">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9Y8"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="InParanoid" id="K1W9Y8"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="25333" checksum="6515E3D88CEDD4F1" modified="2012-11-28" version="1">MSAPTRVANPPTEVPVPFKFDPIEEAIAAIKNGEFVAVMDDEDRENEADLICSAAKVTTEGMAWFVKWTSGYVCLSTTQKRLTELNLTPLLSSAGANEDAKGTAYHLTMDANAAKHPVHTGISAHDRALCSRLVAEGAPADDFTRPGHIMTLRYTPGGVRNRTGHTEAAVDLCYLADLPPAGLLCELVHPTDPAGSMARRDDSWKFAREWGLKVISIADLQAYLNSEKGAKVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAL1</accession>
    <name>K1WAL1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAL1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAL1"/>
    <dbReference type="STRING" id="1220162.K1WAL1"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_3_0_1"/>
    <dbReference type="InParanoid" id="K1WAL1"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="163" mass="17990" checksum="4646F79A6F2E08B0" modified="2012-11-28" version="1">MPQAIAAAEAGVTLISPFVGRILDWYKKATGKEYTAEDDPGVVSVREIYTYYKQHGYPTIVMGASFRNTGEIKALAGCDFLTISPKLLEELKNSTDPVPQVLSPEKAKAAKPLQKVSYINDQPKFAWDLFENQMAFEKLTEGIRGFAKDGNTLKELLKGKISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAP3</accession>
    <name>K1WAP3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAP3"/>
    <dbReference type="eggNOG" id="ENOG502SCU5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094318_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAP3"/>
    <dbReference type="OrthoDB" id="2590379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854684" evidence="1">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="215" mass="23913" checksum="88E58DC5CE66CC51" modified="2012-11-28" version="1">MYIGHFAIAVLAHALLRDVHALPLLLGTSFLDLLDGLLAFPGVTQVRANANAGPYLFYDLIFIDWDHSLSAAAFWSLVCLPLCLAAGYEQRTALATAAVCLSHWLADWPMHNHDLALYPHSERHFGGALWSRLGTWSWILEGLLSALCLIFAARQRQMSKWVPVTFAVTVPSAFAMGSSDTVRRQPLGKCRQPSVRRAHRPWLYRPLLAPGQAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC80</accession>
    <name>K1WC80_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC80"/>
    <dbReference type="STRING" id="1220162.K1WC80"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2442433_0_0_1"/>
    <dbReference type="InParanoid" id="K1WC80"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="90" mass="10272" checksum="D544F3A5FF458640" modified="2012-11-28" version="1">MPRKVVPSTVEGPVPPPPPSPVVQRLRQDWRWAGISQFINTFSDAFGLSDWEIETLENDFDGSEQAVIPDLIAKLLYALTWNRQITQVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGX6</accession>
    <name>K1WGX6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGX6"/>
    <dbReference type="STRING" id="1220162.K1WGX6"/>
    <dbReference type="eggNOG" id="ENOG502RB5H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345125_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGX6"/>
    <dbReference type="OMA" id="ESCTATM"/>
    <dbReference type="OrthoDB" id="2592275at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="259"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="810" mass="85793" checksum="2BC82CE04C5B94DC" modified="2012-11-28" version="1">MTQSLAPSPASPLSPDTAINKASSPEKAKLLSEPRRAPRSPRSPTTASDSSPMSRSHPHPLSQPPINASGPQTPGTTTPAALPSPLPVQPLVKSQSDAPKDRGLPRRRSSFPPGVGCSVTGAGSPTSNGDGAAAQAFPWVVGGTPSGQSFNSLMSRDQMSGYGNNLETSKGNSPWDGSLKLDEAKTTPSKESQVTPSPASKGVSNVEGTSLTNAVNLSLSSKAMLRTPSMERTASGSEHGWRVLLNRNLDVEGMGSIGVARLMSEVWKRGGPEAVSSQNLWPSVVMSLTLSPEHGSSIRQTASNADAASALQKAYETNIRHQESLVFAGFLANYLATTAPPAVNAFQGTKVYGESTPTMEIDLSQWTTFTPGEEWPSLSTTLPSGPGLTPRREITPNLGLPPIDLSENLETMSRSNSRGGMDGAGGLNEILAQIEENNTQRETQSDMFESIGGDWGRTSNISSTAQSSLQLGTPETNIVELDKAPPSTGPKSVFLDESSSSNSPVDQAIGSSLNVSPHVSSGSLLSASTVSSNLPVAPQQQYSQQTMMQQQAQIQPGSMQAQLQPQPQPQQINQQQAQHMQQPQAIAPRPSSARRAPPPSQIALAPVPFIPPPPMCMFFTPAFRDLQKGKVGVWKGDLEIRGRGGGKFNVLIVGEEGSDHLWQSHTWSDSLVYPPQPTLTESCTATMIPVSTLAREGLLPVTMGMVLCNDENIAPFVQMVQGLHAEGVAFHLPLPGSGLPIVFLPAKFDATDQLQRLGVAFMAKGGIAPIPPRPSFSSEEKAKSPVSPPKKRRKSNSVGQTRTSARRKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIZ0</accession>
    <name>K1WIZ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_04241</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIZ0"/>
    <dbReference type="FunCoup" id="K1WIZ0">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WIZ0"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIZ0"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="464"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD01399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="784" mass="90590" checksum="13E78332550E6CDC" modified="2012-11-28" version="1">MSVQARNRRPRGNSPPLPVSEKYEERKWIEAHAQRVDPVRPVIHAEDLRQERLTSYAVALALTFAAVCVRFWGIRHPNQVVFDEVHFGGFANQYLRREYYFDVHPPLAKMLNALAGWFVGYNGSFGFNSIGDDYIEAGVPYVAMRSFVAVMGAVTIPLVYAIMRESGYPIAISAFSAFLVLFDNGHITQTRLILLDAALCLFMALTLFSYVKFHQMRYREFTQEWWFWLLATGFSLACTLGCKMVGLFTFFTVGSAVIWDLWEILDIKRGHTMAYWWKHFIYRAIGLIVFPFILYLSFFWVHFKILKFSGPGDSFMSPAFQETLQGNELLLNAQEVRYYDTIVLKHKDTKQFLHSHPDKYPLRYPDGRISSQGQQITCYQFNDTNNHWQILPTREIPESGRGRVVRQNDIVQFRHVGTNTILLTHDVASPTMPTNTEFTTIDPDNEERKDETYFQLKVEDAHDGEPIKSLSSHIKVMHMKTHVWLWTHKVALPDWGHKQQEVNGNKKADDPSLTWIVDEIIEDGQGQDFQNRTAHVDEKPVRKMPFLKKWWELQILMLQHNAGLSSDHPYASQPIEWPFSLSGVSFWTDSDESQQVYMIGNLLDYWICSIALSIFVGVLAADMIARRRGIEPIESAIRNRLYRNTGFFLLAWAFHYFPFFTMARQRFLHHYLPAHLASALVAGGVINFILVEAVNYPMSKAGPRTRLRPVSRVSLSRNKLYIMAVLFAIVLWCFWFLAPFTYGTSLTPEQVGRRKMLSTWTLHFEPKVTHDVKVGEDTMIIGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJQ5</accession>
    <name>K1WJQ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJQ5"/>
    <dbReference type="STRING" id="1220162.K1WJQ5"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="InParanoid" id="K1WJQ5"/>
    <dbReference type="OMA" id="NYFQTFN"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="544" mass="61568" checksum="880B03A46A4C2F72" modified="2012-11-28" version="1">MTIDTTPQVLDAVVLGAGVSGLYQLYQLREAGFKVRAFEAGGDVGGTWYWNRYPGARFDSEASIYQLFFSEDLYKGWSWSERFPGQPEVERWLQYVTDKLDLRKDISFNSRIESAVWDDDRQRWTIKTSDGQVLDAQYFISCGGMLSAPLTNVFEGMDDFKGQIEYTSLYPAEGVDVKGKRVGVIGVGATGIQVIQTIAPDCKELKVFARTPQYTLPMKNPKWGQADVDAYHSRFDEYKSRLPHTFSGFEYDWDPEKNWDSMSKEERDKHLQEVYDHGSLKMWLASTPDIFFKEDVSAYVSNFVADKMKARLQNDPHLLDVLVPSPDLYGFGTHRVPLERGYLETFLRPNVEAISVRKDRNPIKRFVENGIELQDGRVVELDTVILAIGFDAGSGCLSRVDVRGKGGRSLSEEWGRDIRTTIGLGKHGFPNLLMTAVPLAPSAALCNMTTCLAQQTEWITRLVKQMKEKGETVVEPSEEAENKWVEHHDSLVNATLFPKSDSWYMGSNVEGKQRRMLSYVGGVGTYRAKCEEEANANYPSFVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKV6</accession>
    <name>K1WKV6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKV6"/>
    <dbReference type="STRING" id="1220162.K1WKV6"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573888_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKV6"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HSFDOMAIN"/>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="106"/>
            <end position="210"/>
        </location>
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            <begin position="1"/>
            <end position="104"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="209"/>
            <end position="260"/>
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            <begin position="361"/>
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            <begin position="12"/>
            <end position="27"/>
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            <begin position="232"/>
            <end position="249"/>
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            <begin position="380"/>
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            <begin position="430"/>
            <end position="491"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00415"/>
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        <source>
            <dbReference type="EMBL" id="EKD01904.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="503" mass="57624" checksum="409E7D931ADC0B56" modified="2012-11-28" version="1">MSERPSSGHKRAPSDGSDRLHPHDQRSRPSSRPTSRHGPIKRSPPGTVSPGSSHGEGSRGPTWKTESHSQSASGPRGDSGSPNMSADDGQSPRPVTPGTGMTVNRNQPAFISKLYAMLQDQKYADANLIYWAPDGRSFICPNPIEFARDVLPNFYKTNNFQSFVRQLNMYSFNKVSDLCSATQSDPSAWEFRHPLFCRDEPEKIHLIQRKAGGRSADRRQQHAAGSPDERPSTANLMFNSPQRPSSSRHGSAPRLPQEAMYPRYERYEREPQTTYWNHQPAAPSTEGDVAALERELQYMGARLQAERHESARHSLELHGHLLRMTDMVADLSANDTHMNREELFGFRADVMERYKQLQRQVADGQRYYEQHPGHPPPAPTHTQHPPSSSHSNSSYHDRYHPYRRSPPGTAESRPGSSRYEQVPRAPPPHPWERDARYERYYDDEYYRRRGGRDVRDPRDARDPRDPRDPRDPRDLRDPRDVRDDRFDERAVPEQPASLRNILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPS5</accession>
    <name>K1WPS5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1611964_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPS5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853011" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18709" checksum="4773ACAA503B43C1" modified="2012-11-28" version="1">MRLPITLALALALPALGAPSRRSGEWLDEAREFHDTCVEEQLYSQPDISDWGKGEAKPIMYGDGARGALERCQMMMLNDANRLAQAQFPGTNVFTIRTDLGIGWYVAELVAKESLSSVRWPSGYYDYHTVVFRGEGHLYLVGREGEHERRWRGNAQRNGDTVDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQ80</accession>
    <name>K1WQ80_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARF guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
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        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="922"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1715"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1767"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1668"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1795"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1808"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1822"/>
            <end position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1872" mass="201738" checksum="87F919010E4F05A8" modified="2012-11-28" version="1">MPSADPMGPAQPVAAKTSTLAAPATPDRNKRRTWFGLVTPTRKDQRRTATLSRQPQPAAAPTPTTPSNSNGLEELDATPDAKAINKTPVQNQRQWNDEDQLGSERDWDSDQDGTVRYKGSRIKANSEDEPIRMKDMATLATLTRNNTVKPKPSFSRRIFSRGATDRDTLPADFLSPSKGQMPTSVISPSKVPQRSSSVTSSSIPVETNPNPPPPPTKLDLERSPMPKPLPDVPPFSNGFNRGPTLNTDIAGPADIVITPSSPLEEDPFEHIFGLGPSVPNRSMSAPVSPTPTMHTALTSHGILGGSSSAGTSPGIPSPLSRTPDIEQSALGLGLPRSHSPHSRGSSPGPRVAVSSPLPQNPSPKVAFDEEQDHPTSKPGSSKTRPRSLSLMFSKSGGEVTDDEDSGTSKFSWLGVGKVIRRRRSDMKLMRKRSGILTDNEMSNDSSPMDTTPNGGERTPEHRSEDTNRSRSPAPEVVLSDPFRRIAPSQSPEPPQNAVRQENGSQEVGPTDPVPEHAPAKPQPVMIPVRNAPRPQFSMTRPASSDSFASTSEQEFYPAQEWSDSSISESPMNEIDLTAAQAGADWLMTKPSSAASPLGSLPEGSMAPPITTTVADASLVPDVVTPSTSMPPRHGRGRSLSDAARTSIPEDPGLLSPDGAPVRPPLSSRSSSSNSAVLGKMRGVFTKSNRPRSNSLLRYTGSGTSADEREDGRQTPHSRPGSASSSFAPSPALPPVRIRPEDVPQVSTLALQSGDDGRRIILTETPPRSPRSSYAASVTSYQTQSTVQTAQSNRRSATDNLMPVTNGRNRRARASTIASGAISWHGSTFGGSTPALVAPPPTSFSPTSPGGLQRTGSLRRLSQGLFRGSGPSSPKPQGAFPLPPRPVTPTIALNDEIPQSMGTPGRSSSGDVSLQGRSSTPQLTEKERKERDAELHPRPGESAEDWLERLESVSRKEVAGLLAESADPFHAGALAEYMRRFDFTHIPLDVALRRLLMVMSLPKETQQIDRVVEAFSKRYDECEANLFGSTDNAYVLAFSMMMLHTDAFNRHNKNKMTKADYVKNTRLDGVSPTVLEAFFDNITFTPFVFIDDDEEAALAAAGMAPSSSSRPNHSGKIDVYDLIVGGQLGSLRVDVERYIPPDSPFSCMGTRQFLDVDRLQKAFANAHPLQFVKSRPRRKSLTLTGVVERPTTPVPKEEIATIKITKVGLLGRREDHLHGNSRRAIRRGWKNWSVVLTGAQLLFFKDTIWALTLVEKIRSANGESQAAQTTAFQPDEVMSVKDCVAIYDRSYAATPYTFRLLMPGGNSYLLQASDEHQMNEWLTLINYASTFKTAGIRMRPLGMDGDKAVLAGNAAAESHRRDLAAGVGSVVDLLRSAESSNYTRAVVFAESETPEPLAPKPRALRRVGSVRATPTVDIRGANDMVVGGSEQFDAVMGSVREELLRVTSPVPPSGDGPTRADRRRALIESKIGELKLLAEPVQAALQADLRLARNLALLTPFQRATKERIEAALPELSDRIRADRMELSKLHLWITMLLKDQEREAREWSWAKSVALQAAEKHLVKTKSGRRNTVDILGVPELSLPDADDEEHELELRVASPIPFPEREDVAIGALAAGAAGAGAVGVGVAGASGAGLTTGLAAQGHGLGLPHPAPQYPSYSIPLKDAEPASPRSPRSPGSERMSQISQGSAGGSGSEYMSARSSMLSFEAELDKTFGPRSPSLSLSPSKFKNKAQAQAHTQAMLTGAPIPTSPPAVPQSLANLQLGYPSHHHLSEPTRHSAQWLPDEPADSALPHTPSNTSNLSNPSSQAHTPSQPASQPFPGDRDNELLKPEDPREQAEHWRHTRAASKVSLAKLPRSSIGELTERIRRDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRF8</accession>
    <name>K1WRF8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAO1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRF8"/>
    <dbReference type="FunCoup" id="K1WRF8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRF8"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_2_1"/>
    <dbReference type="InParanoid" id="K1WRF8"/>
    <dbReference type="OMA" id="CRLLHYF"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000035">
        <property type="entry name" value="Probable fatty alcohol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="359" mass="40483" checksum="DF2D804318C5486D" modified="2012-11-28" version="1">MHVPTISLRDFDGRRDEIIQQLMDASTEVGFFTLSDHGIPQEDVDSMFKMSQRFFALPDDVKAKTPLDGKNAGWEKNTQVRPSTGTADQKESMQLQFARMEGLWPSDEDIDGFKRKSEEFMHQVQSLSVKVMECFADGLGLPKDTFTIGTVDREGKGDSQDVLRLLHYHSCEGKTFGPNFWRAGAHADFDVLTLLFQREGEGGLEVCPGRKVVGDFGMGQEWIPVEARQDRIVCNIGDQLMRWSDDRLKSTYHRVRLPEGNESRGPRYSMAFFNQARTDEVIQGPNKKYPPIVSHQSRAEADIQTGGQFIKEALERNRMQSAEIAAKARLESADKVASEVHFIPEHMKKQADAVPVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1WS88</accession>
    <name>K1WS88_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_01872</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WS88"/>
    <dbReference type="FunCoup" id="K1WS88">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WS88"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="K1WS88"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 21" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="46"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="231"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="486"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="593"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="700"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKD03859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135213" checksum="DB2399B10C83ED51" modified="2012-11-28" version="1">MTFDPLSPSKATSSKYPDKSTFRTLTRERAFRHPNPNGPDYATHEELVRPHIESFDALTEGDDGQPGLLQLGVQDIGEKIIFDGKSEEGLPYGNKITYRISQVALGKPLVSDRDKTAVERRIFPSEARERLTTYRSRLTVTIKWKVTTADGTTRESEEVRECGMLPIMVKSARCNIRGMPAAELVKHGEESSSWGGYFIINGNEKLVRYLILPRRHHPINLYRPSFAKRGVSYTPYGCQIRCVRPDQSACTNTIHYLSNGGAMLRFAWRKVEYMIPLVLILKALVDASDLEIFEGLVQGEYDNTFLTDRVELLLRGQKSWNLQTGTQCLDYLGDKFRVVMNCPDDWTNVQVGSYLLKKVVLVHLPQPREKFRMLLFMLRKLYSMVAGTSCPDNPDSPQHHEVLLPGFLYAMIIKERFDESLNAVKAQINMDMRQGRAKSFDDPKYFPSVLTKVNFDVGSKLSYFLATGNLVSPTGLDLQQTSGFTVVAEKLNFYRYLSHFRCIHRGAFFAELKTTAVRKLLPESWGFLCPVHTPDGSPCGLLNHLSHTCQIVVKPLDTSKIPQLLSAHGMTQVFATGIDGRTNVVVQLDGRVIGWASPTKAKELADLLRKLKTEGDARVPLDLEVGYVPVTKGGQYPGLYLFGSRSRMMRPVTYLENDKMDHVGTFEQVYMDIAIKPEEVEKGVSTHVELDPTSMLSVLANLTPFSDFNQSPRNMYQCQMGKQTMGTPSTALQHRTDNKFYRIQNPQTPIVRPSLHNDYGFDDFPNATNAILAVISYTGYDMEDAMILNKSSHERGFGYGTVYKADIFDLKDAARSRTAAPTLHFGLGRDVKPDSPWRQFLDQDGLPQLGTRVKSGDPLCAYIDDTTGRTKVHKYKGDETAYIDEVRVLGSDLGDSELQKIHIKLRIPRSPVIGDKFSSRHGQKGVCSVKFKDIDMPFSESGMRPDVIINPHAFPSRMTIGMFVEMLAAKAGAVHGQCQDATPFKFSDAEGPVEFFGEQLRKAGYNYHGNEPMYSGVTGEEMRADIFLAPCAYQRLRHQVNDKYQARSTGPVDPLTRQPVKGRKRAGGIRFGEMERDALIAHGTSFLLQDRLMNCSDYSTAWVCRGCGSLISLGFDDSVGPTNDGRPRQYCRICERNEQPGALDGAVQDKSVGVVAKRESTATAASSKMDVIAVPGDDGSAPNGGGLRRTESILGTQHALSACRTGHEGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSL7</accession>
    <name>K1WSL7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01744</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSL7"/>
    <dbReference type="FunCoup" id="K1WSL7">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSL7"/>
    <dbReference type="eggNOG" id="KOG2628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_0_2_1"/>
    <dbReference type="InParanoid" id="K1WSL7"/>
    <dbReference type="OMA" id="AMYHIAN"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="294" mass="32295" checksum="9FA90F03FA34A1F2" modified="2012-11-28" version="1">MATNGTTRVSGPISGEQLAEIRARIIASNSDSGVSSGQTTPARTAAQSGLHMPKSGHYEAKETIPNTPLAASVISVALGAAAGIAATCAFQPLLRWLGEANWTWARPQLGIYLTAWATFHILEFWTTAGWNFQKLSVDAFLLNNTNEYHIAHLVGLAEYFLSSYFWPAKFNSVVASPWVLVVGLLVAGQSFRSLAMVHANKSFSHIVKTVKLEDHTLITHGVYSHPSYVGFFYWAVATQLLLSNIVSTIGFIVVLGRFFRSRIRDEEIHLTRFFGREYVDYKARVGSGLPFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WT73</accession>
    <name>K1WT73_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WT73"/>
    <dbReference type="STRING" id="1220162.K1WT73"/>
    <dbReference type="eggNOG" id="ENOG502QVFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906694_0_0_1"/>
    <dbReference type="InParanoid" id="K1WT73"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="123"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="307" mass="34386" checksum="6083F08E51C0687F" modified="2012-11-28" version="1">MAPIGTSPFRPRSRSGHANRSPSPPPLPPKSNNADAASSTGSATMIPSRSSRRAFLCDLIIDSNATGQHTNAMLSQLGQPLERPNCLPRAAELPQPQNSYADDIMAMSAAGWTASKQEEMDRRLQSLMEELVRTENSYVSRVLALQKNYSKPLMNFSRDSQTRIIKTYEVRRLFSNVDAVVPAALAFQEDLQKMWAGGRAAEIIGDLCLDHLKTRKTMDPYRTYISNQDEAQKAFQELYKKDEFRNYVDRTKYHTTGIGNIGLRELLMEPVQRIPRYTLHGEVHVAHVDAAGKAGRGHRDRVTDSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUL0</accession>
    <name>K1WUL0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-rRNA processing protein associated with U3 snRNP, Rrp9p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUL0"/>
    <dbReference type="FunCoup" id="K1WUL0">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WUL0"/>
    <dbReference type="eggNOG" id="KOG0299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014017_1_0_1"/>
    <dbReference type="InParanoid" id="K1WUL0"/>
    <dbReference type="OMA" id="CRYWKIR"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="463" mass="49931" checksum="F94FC6B603E834B8" modified="2012-11-28" version="1">MPDAFFKSDKKRKRSRNGGGGGGPSRGGPRDDMPSRGRGRKQQKEDEDLSDTGDELDIDDMDFQKDRAPHIMSDDEFVDANETAAEKRVRLARGYLDKVARDVQQAREEDDYDAADIDRELIASRLKQEVDEAEGRIHMFYSSASASNPRFKALGAVPTGVGMVLSKPKSSSDGKVTGVEAIYVSTKGGVQRLDPGLKNAPLHSTEGGHQGPVLCMAASEDGKWLVTGGQDRVIGVAPAAEQPDIPPPLCLSLAPPDTALALDALATGDLLWTPGLDPERLGAEADDVEEEVQLVLRAGGKTRTPEGEWVEGSVDVVTMLDDSHFVSGGDTGSIALWSTGKKKPLFTHVLAHGTDSEGHNLLPSETGPKPRWITALAHLRGSNLFASGSWDGEIKFWKIDSELKRFEEAGSVNVKGFVNAIQILNTPKGIRLVAAVGREPRLGRWVTVKARNGVFVADVELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUQ5</accession>
    <name>K1WUQ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent RNA helicase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000220">
        <property type="protein sequence ID" value="EKD04594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WUQ5"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260443_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUQ5"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="860"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1127"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1162"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1314" mass="139451" checksum="C77A22BC9BD89333" modified="2012-11-28" version="1">MPPLMRFPAPALPQLFSPGLDMESLAAANSPYRQPAPPPQLPMLQLPGRHQEPLWYDPNDDKQAGPSCPHKSRWPACGAHVSAEKRLAAFTDDEVEQISQDIGLIVRREFDSWVEACWTEAFHHVFTRTIPTFLISLILAGASPTLMRKHIVHGGLFESGFSVADISARFRLHVRATQTLVLDGAARARSLSPRLQERLRGEIAEGDAIWRNYSALRCIVWDAAEAAEATEAVDADADGHEVAVPGADGAAGGAAGGAAGESNGLAFVCITSNTAIPALEVKFFDAQGRVFLHPSSVLFNESGWRKGYLAYFAKAETSKVFLRDATDVPLYALLLFGGPVTVNHWAGGLMLGKDGAVKLRANTRIGVLCAQLRRLLDAQLAEAVDSPHGAADVKEDVVGAMMALLARDGLSASGTSARAQLSSFVTPVTPPPPSPTITPVRPPSKHSAIRYSVEAHSRLMFKRMSASAVFATTSTATAGSVGSVGSAASAASVGLGGNAGNAGTAGNAGLGATTTVTATTTATASVGGSGGGGSLGGPVPGPSGSADSPISVASGSAWEEDSVVEISPHRPRAVPAPGSPSPSPRPTASSKPLHPFFTRPRVPVPRQPRLVATYASTSSSLYDSQSQTGTQSQSQSQGTEFSQSSGSFFSSNTEFFSAASELSFASQSQQSQESGRSRGDVVPPPHGEPSFRPSTHISDLTAELLRLDIRADAGIDDRGWTERTGERDRAIRAVRAGVQRRTASMTLAKEVMEPTAAEWPALSPTSRTVPLKTGYASVAKKGVTTAATAKVESPMVETTLEKPPSRPTSPTTKTAAKPPTPPPPATAQHPPKPPTDEPSDLPVFSHKIPIKGHFTRPPNVAYTTDPAEVEDLIGCLRGPLSLDLEWPPPGQGKAIPRKLRGGKIVHIRRPVYDAKLGKNVWPEAPVSVVQIADARLVIVFQMLHDPEIHVRARTQGRNLTMPHSMPPALLRLLADPERVKCGVNIKQDGNKLWRDFGVPTAGLLELSAVARHVDSARWPDKGLISLARLAAAYLGADLDKGDVRTGDWSARLDAEQVSYAANDAFAGRLIYDALLKRGRETDTTLYIGNMCASVGCEQTAGRRNAQGPTNLKPTAEPYKPLGKRSASPASPGTSPKLSPRATPFQPHVVQARPGTNAGPRGQQQPVQPSQQPSQYYSPHQSHQPHPTHQPQPRPHSFPHLPIPPPHPPPQASQGKPLTAFSLFESGFSVADISARFRLHVRATQTLVLDGAARARSLSPRLQERLRGEIAEGDAIWRNYSVLRCIVWDSAEFGDGPGDGAREEAANAENGTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WV70</accession>
    <name>K1WV70_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein alpha subunit Cga2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_00944</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WV70"/>
    <dbReference type="STRING" id="1220162.K1WV70"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="K1WV70"/>
    <dbReference type="OMA" id="GKKDYMP"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="171"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD04714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="347" mass="39637" checksum="9531A8F1F1695AEF" modified="2012-11-28" version="1">MGCTQSVEDADAKALAGNAEIEEQLKRDRQEMQREVKMLLLGKSTVLKQMRLIYNKPYDPEERESYREIVYSNTVQSMRVLLEGVAHFDLQINGANKARWEAIMNAPDLVEGRVMPPALADAVMGLWQDQGVRSAYARRNELQLNDSAEYYFEAVDRISQANYTPTDQDILRARVKTTGITETHFHIGELHYRIFDVGGQRSERRKWLGIFESVTALVFLIAMNEYDQVLYEDETVNRMHEAMTLFESVVNSRWFLKTSVILFLNKMDLFKEKLPKSPLNVLFPEYKGGSDVKAASQFLMETFTALAKDKTVYPHFTDATDTKGLAFVISACHDVLIQANLRNAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVA2</accession>
    <name>K1WVA2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVA2"/>
    <dbReference type="HOGENOM" id="CLU_548828_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVA2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="426" mass="48707" checksum="B76977DC118DC0E9" modified="2012-11-28" version="1">MLEFFPNVHSIHFDTTGDSYLRAMHKGGPGRAADELRMEEEIRIDRLTFCPPRERYLPEGLNYECWYHLEGVTADQWSTAFFDRDDRGELILPDVLRLPAYQLSVWNIDGGNPEWFHVLRRRKAMGIRTRNIRWRIASFDELDMLAETAGVGLRSLEVSCYIQVFEDTSQTATAIMNRIDATRFPDLQTLTLHIDFPSLTAPTPLIAPEWLYKDMPPHLSSIQLDLVLDTWQVDETEGFLPMEYVEYVFEERAPRKFIIDVRTKFGGDFSFFVNTEYYDDNGVVDYPRSNSSFIDFLLFEPLSVARGDSSSSSIDLSSGDDYESDLEDEPESESGEEESSAQSEAEESVDDIADDESMRGSEESRYDEYGLGYDDEGASAQEDDDESRSGSEELCYDEYGSQEEGQDEDASAEDVYMESDDYPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1WYH5</accession>
    <name>K1WYH5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000026">
        <property type="protein sequence ID" value="EKD05674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WYH5"/>
    <dbReference type="FunCoup" id="K1WYH5">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WYH5"/>
    <dbReference type="eggNOG" id="KOG3181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_2_1_1"/>
    <dbReference type="InParanoid" id="K1WYH5"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="248" mass="27665" checksum="6086A236A6BAB850" modified="2012-11-28" version="1">MSVAHQVSKKRKFVADGVFQAELGEFFTRELAEEGYSGCEVRVTHARTEIIIRATHTQEVLGHQGRRIRELKALVEKRFRFPENSLELYAEKVQYRGLSAVAQAESLRYKLLGGLAMRRACYGVLRYVMESGAKGCEVVVSGKLRAARAKSMKFSDGFLIHSGQPSVDFIDYAVRHVLLRQGVLGIKVKIMRPHDPEGRMGPAHPLPDQVTLIEPKPETEITIHSVHKDVPPAQVQAPAAAEQQTEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2W0</accession>
    <name>K1V2W0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA ligase,putative, Trl1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2W0"/>
    <dbReference type="FunCoup" id="K1V2W0">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2W0"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010316_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2W0"/>
    <dbReference type="OMA" id="EFTSHIG"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="2">
        <location>
            <begin position="467"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="1">
        <location>
            <begin position="675"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="884" mass="98546" checksum="92AC171FF21A84C9" modified="2012-11-28" version="1">MTASSSSSTVMDPYPAAVPDLLDALRALRRNNPKATRSNIHIYPARLYAPNDPSQSDRRLTSWKMTEHMYFRKDNGFPTLARGLFTEEVQPGAVPEAALETLGDEYAERIVARGYDKFFNIDEMTWTTSNGCLIMISALSPTHLVVASKHSLGTTTEEATTVADVTHSLKDTKLDDKKTEEAKDESSARAHAEVGREWAARTLKKSGKTCEELAQRLWDENLTAVLELCDDSFEEHVIATPEYWTGLHLHGLNYNQPHFSTKSPEDVTAFANEFGFIPTKHVTLNSVAEVRKFANEVAETGSWQGDMIEGFVVRSTVKEVEGHESSKPPYRPGAPFFFKIKFEEPYLLYRQFRETTRAMLQLMDKKITPVKEADIWKKVKAKTRRPEVGVYAEWCADMMKKEPSLFANYERGVVRVRERFLKWIEGDGKKTWDLAQAGEWKAGMDKAAEASKAAREAERESLPKKWVVVPVAVPGCGKTTLGLALGKLFGFAHTQSDDILSKKTAPTFKRNIVELLKTNDVVYADRNNHIDKHYIELSGLADEKTFAKTLKPYHVKYIFVTWNIDDNPFHKLLRLCSERVVNRGDNHQTLRPDLTVEAEHEAVVANFLHNFTTPNPLYYDEQIVVDVEDTPRAALGKVVDSLVKMLNLPRPSEEDIDAALAAVSDYKVTTPYHAPARVGKAVRYFGLAPEIDINAVVDDALQTPMAPAASESATKFMTSLREKGRVTQRPHITLSHNKNVAAEKEAAEEGAAPGPQQIAWETCTALAEARISPFYDFDVTHLAWDDRTMALVVGNLRPQETSDREKGAALVLPEEVEINLHVTVGTQSEEISAFESRGVVRTAREAIAKGVQSGEGGESTEGGGAVHWVKVGPLKGSGRVRGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5P8</accession>
    <name>K1V5P8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5P8"/>
    <dbReference type="STRING" id="1220162.K1V5P8"/>
    <dbReference type="ESTHER" id="trias-j6ez91">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_2_1"/>
    <dbReference type="InParanoid" id="K1V5P8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851627" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="68"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="522" mass="55039" checksum="919C2AA51159B043" modified="2012-11-28" version="1">MVLGFTHLLGLFGVLQAISAAPATSCQLQWGGVTIDGHLGDNNVCRYNIKYGSAERWGESQATASPADGSGLPPACPQGGFTYFTGNVPQSEDCLHMLAYVPQNADANTPIFTWLHGGSFRFGGASMSGIDGSALAAKGQVVFVPQYRLGMLGMMPPASSSTANDPNLALRDVVLALKSIKDNIGSKGNKNAVTLGGHSSGALMVRTLWSMPSAAGLFHRSMLQSDPSGQGLSTVSQYQAVRNKVYGYASLKDKSLAELKSANPSVFEEAINTLLSSLPYDAWLDSPNLSINPVYGTASLPSDPTAALVSNKGQLAVNPSNMPLFVSTTKDEAAYLVSGYWPNPIPQGYVMGAGNKGAIEYNSVMQGRCANGFDLRTQDTYWRDSAPDTVRRAVSLAVTDGGVRCSSRAVASGWAQKGGQAFVAEFTKGAPFLYSQSSGSSFCDDKVCHGSSHPAGADVQANEVADIWTKFIHGQSMGWNAYSANAKQQNTNIKAIGGGSVANCPKSGSNAFWGTKCTWNWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9X1</accession>
    <name>K1V9X1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9X1"/>
    <dbReference type="STRING" id="1220162.K1V9X1"/>
    <dbReference type="eggNOG" id="KOG3743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008944_1_0_1"/>
    <dbReference type="InParanoid" id="K1V9X1"/>
    <dbReference type="OMA" id="CPPRVVI"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000003">
        <property type="entry name" value="Related to J kappa-recombination signal binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="330"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="490"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="106522" checksum="2155490309598D4C" modified="2012-11-28" version="1">MTEPGSSDYFDLAHHTSSSSHPPSTSTTLRSRNTSISLDPSQPQSTAGSSSHFHSWPATPSQPAGLMFHNPQTDGGPVSFAPHIPFPMGQNNKDETNGLGLDPGTGAGHDAVSSAYGFNLMANGMPPPSPFGFAVPPLPPNMQRPALALDTTGSNFHIPQTQPGSAMSPPLTGLDLSGVDMAGVDRILTPNFYAPFQHDMGMGGAIPPPTFYDPGTISPSQLPHQMLKPTKSFSDLLIESRQSSLSASSTEHEWNSGVEDLSMPLARALVMEQQSPALGGHAHLANSHQRAASLDMSQLNGNAQQRPELLNQALRMYNAAPNRLAFGERKIIIMSPKVGQKSYGTEKRFLCPHPQATLVGKSWFTSNKDDCPVSPLIPPRVNISLSGEAAVKDVHIHTQAITEDDKPFLGNVAGKNLHISDSDGKRREVKALVTVRVPSPQHAGPHGWGPAKGTMTEAAPDRVIGVFESKEIKVISKPSKKKSSSKSAELIIQHGSTIALFNRVKSQTSSTRYLSVPIDLTRFKGSDGKPVTGALPPDVTPSESIFRGFTVNPSVWESFIIYLVDPTQPVGVSNVKSPNPGWPNLPSNAIPAHMAPPIRYNSTVVLQSLQTGLISPVLVIRRNDEGSEVVGMDGTATDNPIACPEGELPGNAVSQLQKVAFEVYQPESMRNYQRDPTYGGLWLSCDQEAVREQFVNAERRWTPVPASARGSAAARPASLPNTPQTRFGVLPMTPHTASVALPSGPPSPISSSSSSDYFGAHSRKSSSSMLFSPLSGELPLPPPSTDGGPVRRQRTGSTTNSRGGPLQRPMHKKRASADIPTSGGSFDFSANGMLTNVPVVQDRTYWTLDVGDVCIWSIVSTEQVTYTFYVPPYASELSEPLAPFPMAHRLLPPNMSAEVTMAKYNHQYTSMATMPLVTFYGKGFTKRPDGHACHIVYYGDQPAVHNEVRCHEVMAAAEPAPSAHPQPVFLVREDGQCILPTGLIYPAMQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB28</accession>
    <name>K1VB28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 6"/>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB28"/>
    <dbReference type="FunCoup" id="K1VB28">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VB28"/>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022882_1_0_1"/>
    <dbReference type="InParanoid" id="K1VB28"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="9">
        <location>
            <begin position="122"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="10">
        <location>
            <begin position="290"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="523" mass="58047" checksum="21F6A1FC1E3DBC33" modified="2012-11-28" version="1">MAADKAGPSTQNSGDADKELSSKLQDLSTHDEGDSDDSGDEEANNAGPAEAGAAKKKKKNKKKKKGKGKSTELRLAIKQALKATDFLKLLESQLGMEGQAKAVADHKPVLQNEGDEVKEGPIEHKTVAEVKKEPGALPAGFEWSIIDVKDDAQVHELLTDHYVEDDVAMFRFRYSKEFLLWALTPPGYYKEWHIGVRVQKTGKLIAFISGIPVELRVRDNTFMNAEINFLCVHKKLRAKRLAPVLIKEVTRQVNLTDNWQAIYTAGVRIPTPFSTCRYYHRNLNPPKLVDIGFSPIPRGSSIARMVKQCAVPTTPSTPGWRAMTQADVPQVASLLRRYLARFQIYQTFSHDSEVEHWFLSGMGREVDGKRVEQVVWTYVVEDPESHEITDMMSFYSLPSTIMQHPKHDVLNAAYMYYYATDCILSGEGSSSSSDADSAKTTAKLSARLNALVADLLVMAKSEGFDVVNTLTLMDNNLFLQDQRFGGGDGYLNYYLYNYTTAPIDGGASGTQSRQTSGIGVVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC55</accession>
    <name>K1VC55_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC55"/>
    <dbReference type="eggNOG" id="ENOG502SP0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139288_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC55"/>
    <dbReference type="OMA" id="QIHQIAR"/>
    <dbReference type="OrthoDB" id="2772415at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="115" mass="12530" checksum="714AC8B5F230A085" modified="2012-11-28" version="1">MAPVNLVSVNTAPERAKVVIGTVIENVKDKYDIVHAGNSTTIEGVKPLLESVQPPPGILFCASMWTPEEQEEIQRIARETVPGIKTHAIPTGLQVKVGPDGVIKYLMERIDEIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD06</accession>
    <name>K1VD06_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD06"/>
    <dbReference type="STRING" id="1220162.K1VD06"/>
    <dbReference type="eggNOG" id="ENOG502S960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055001_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD06"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="437" mass="49717" checksum="91967F6A17BE70FD" modified="2012-11-28" version="1">MPTVERIPRGFHHLDKVLHSKFVNSRYAARMPRPGRKYTAPKDRIRRWNIVPGDKVRLMVGKPEEKYDTTKQGKDGAKGKVWRVYTVSGVNMVHNRVYLDGLTNVRSNRTQPLPSEEKLAKMTEDERHSYLQQRNFISQRRAVHYSSVQLCVRDAGADSVFATRVATTAPFYDRATRSARWARYAAALSGDGSMLPRDPARDQVRIPWPITQPKEKADPMPVDTLERASAASTLNLQDASRIPRPLIPVSLRGPAPGPQDQDWADEYVFAPESRTSPELEAALPLYLQEELSPRYSRAKQIKGWNQRRAAEAEAREAYVAAAVDEWEAGGRDRGLEELLTLDAVRLEGITLRPRTRQEIRDAAGREFDTQLAHTRKLTRRAAAAGMRFVEGQWVPGAKGEEIQRKKSRKERKLRKIEERLNRIKLEDAPNQAIPLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDQ3</accession>
    <name>K1VDQ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDQ3"/>
    <dbReference type="HOGENOM" id="CLU_3144017_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDQ3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854096" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="49" mass="5179" checksum="4E3674A37A401132" modified="2012-11-28" version="1">MIKALVALTFTGVAMAAPCPSTFRIHPEGHDDYCVTVAKTTDNPGPAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDZ3</accession>
    <name>K1VDZ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDZ3"/>
    <dbReference type="HOGENOM" id="CLU_837254_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDZ3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="332" mass="35880" checksum="6D144B52DD546452" modified="2012-11-28" version="1">MFGLRWLTCCFAQNTPLLAPPAPTKATTQPTATGKPLAALSALLGYGYKTETSDTAANEDEVLRSPRRPALVRSDDSDISELDASALESAQRAREQAEQARIEEQIRQGSVANLYANRMCKVAPLAWSAYRRGSVDSSGMGSPTLKTPVLITPQTSREFEYDEPVRHSPPSPHAETESESGSQLHGLGFKNPPPGFGARYSARYAAPALPPPPVDAGIAQMLFNVEAREFGTSPNPHSARYSDSEDSDGTERGRSRRLSPITASGDEVVYKSIGLAGLGAGSARLQTSLMSWRHSEEPTSPAPPRQSIRLLMRPSTLQHPARSETIQRHPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE16</accession>
    <name>K1VE16_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE16"/>
    <dbReference type="STRING" id="1220162.K1VE16"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="K1VE16"/>
    <dbReference type="OMA" id="KCCCSIF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="195" mass="21780" checksum="56353CE6C7780DBD" modified="2012-11-28" version="1">MAATRSIKLGDGAVGKTCLLISYTTNAFPGEYVPTVFDNYSSQVIVDGMTVSLGLWDTAGQEDYDRLRPLSYPQTDVFLLCFSVVSPASFENIRTKWEPEIRHHSPGTPIILVATKLDLREDPVAIEKMRERRQQPVQYAQGLAMHNDIKAARYLECSALTQMGLKTVFDEAIRTVLNPGRRSGKPKQRNGCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE27</accession>
    <name>K1VE27_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophan 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000295">
        <property type="protein sequence ID" value="EKD02240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE27"/>
    <dbReference type="STRING" id="1220162.K1VE27"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_2_0_1"/>
    <dbReference type="InParanoid" id="K1VE27"/>
    <dbReference type="OMA" id="SNKIMEP"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="513" mass="55704" checksum="A065030B2556D832" modified="2012-11-28" version="1">MAHPHPLASLPPGHFLALPPTFSNDPGTSITTASHAAPSAPNVASLAAADFDVDPGDGVRLGGGRPKDEAWREGVRAMPVLDIAGLNDLPLLRRAHLVLAFLLHFYVHTTPTEGEKPTEVPACISVPILKISPLVGLPPVLTYADTVLWNVQGTDSSRLINLADNPPTRTLGTFTGTKSEAGFYTVSAECEAAGAAALALMRQCLDELFLADEVALRRLTVYLRQLAVQIDRVGDITLKMMTEVDPEEFYHLIRPWFRGGDGSGPDAPGWLFLGTSGDDSLGEAENMLSASTYTTEDGEEVRGRKFSGPSAGQSSVVHAFDVFLTVDHAPRADEDSESIAVAGGTESPRIILNSSPLVQHHHHDDEDDAPLATPTEQSGGPVEATFLQRMLQYMPLPHRTFLLHLAAHPTPLRPLVIARANTHPELAEAYNEALAALRRFRDKHMRVVSRHIVQQARRPPSERILKLLGREGEVAEKQEDVSDDQLRGTGGTPLIRFLKRCRDNVSRAMVKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEX6</accession>
    <name>K1VEX6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_06352</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEX6"/>
    <dbReference type="FunCoup" id="K1VEX6">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEX6"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="InParanoid" id="K1VEX6"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="561"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="492"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="979" mass="106876" checksum="84003C4C57819B13" modified="2012-11-28" version="1">MSTPRGSGRGMRSSSPALEWPTSSVGGTPRPSSAATPRASAIRRQGNGVAASSSPLHFPSDGPAPSSSRLSQLRSDEPLFFPASGGSTPRRQRRGDIHSSFPMASPSLARYAGRNAQPLVPSSPGRSDAATPHATSAAALSAADIPTGDATGDDEITEKYIWGTTIPLQTTMNLFRDFLRGFKPKYRAKYNEAQAKAITDAGGIAPPPMPLYDNLSTRDADKPLYEGYIVTMRQTGQTNLNLDALNLLAYPPTKRLYHQLVNFPQEMVPIMDQVLRDVITEEAEEELQDAVTKHAEGQVAELQLHVLENELQEIEQRVYRVRPFGGEKTVNMRDLNPGDTDKLVSIKGMVIRSTPIVPEMTVAFFRCHVCQHTVQVEIDRGRIDEPERCPRDVCGSKGTMVLVHNRSVFTDKQVVRLQETPDVVPDGQTPHTVSLCMYDELVDLVKPGDRVLVTGIFRSMPVRVNPRQRSIKSLFKTYLDVVHVKRTNVGRMGFDPTTRDGEGKPPGVGVGGEDDEEEVRPGHPMRARGHDGAGYGHARPRPVGFGRDGEKLLELSRHPDIYDMLARSMAPSIYEMEDVKKGILLQMFGGTNKSIARGGGGGGPRYRGDINVLMVGDPGTSKSQILQYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPDSKQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSIAKAGIITTLNARTSILAAANPVGSKYNPKLPIPANIDLPPTLISRFDLLYLVLDKVDEMNDRRLAAHLVGLYLEDRPDTGGQDILPTDVLTAYITYARAKVNPILTESASNALVQAYVEMRKVGEDARTAERRITATTRQLESMIRLSEAHARMRFSDTVDLEDVVEANRLIKSALRESATDPLTGQIDLDLITTGAGQTARRVRADLKREILGLVDAAGRTGLKWNAAIKALENQSSVPVDHAEFAEVVKGLCDEGVLKVVGEKDRRTIRRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF52</accession>
    <name>K1VF52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF52"/>
    <dbReference type="STRING" id="1220162.K1VF52"/>
    <dbReference type="eggNOG" id="KOG3290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048953_0_1_1"/>
    <dbReference type="InParanoid" id="K1VF52"/>
    <dbReference type="OMA" id="KYSEDNW"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32599" checksum="61CE55272F0A64EB" modified="2012-11-28" version="1">MSLTPEQLEQWERDGYLALPDFLSQDEVQKLLGRTHELLDAFDPASHPLTAFKTGRQDGEHVGDDYFLNSGDKIRYFLEPSALSEAKDGEPPKLLYPPARSINKIGHGLLADPVFREVTTSDKVKDVARSLQGNIKEPRVLQTMIICKQPRIGGVELTPVPCHNDSTFLYTDPPSAIGCWIALEDCTPENGCLAKVHTRFVRSPNGGTEFEPVPGVEKGEEDWDKMDGWKEVPVKAGTAVLIHGSVMHRSPPNPSEKTRMIYTFHMIDGAEGIKYDEKNWLQPGPEGFHALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFT6</accession>
    <name>K1VFT6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFT6"/>
    <dbReference type="HOGENOM" id="CLU_1556368_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFT6"/>
    <dbReference type="OrthoDB" id="2571236at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="172" mass="20138" checksum="D0FF32C9279D3414" modified="2012-11-28" version="1">MQRVTAKKDVVNNGEYRAAVQGYAACLLDLMPWYASPLLFTARHAYDTGIVHLVLKATTLPVMNRLDLGILAFETVNWMRYAPSKALYKARYVKSHDEYEQFSSIPAAREMTDVMRECAEEMSNKDKDEWAHRFCFREHVCFTPRYLLKIRTWEREQVRLQNEGPNPLDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFV6</accession>
    <name>K1VFV6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THO complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFV6"/>
    <dbReference type="FunCoup" id="K1VFV6">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFV6"/>
    <dbReference type="eggNOG" id="KOG2491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021106_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFV6"/>
    <dbReference type="OMA" id="TTQGHIP"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="80436" checksum="54C7A8FEFB735BA1" modified="2012-11-28" version="1">MAATTLHSRLTDDLSGLLGTLGKKRLTELKKHKGAAPLKPLDADDLRSKVDAIWSKNHDEGPSSRRPDVLRGTMDVVGRDLALRPVVSGELSEPEYGASEKEQASFQTALQDRLDVVLTLYEAVYATHAEALLEPGAIFIPLLEEFVELLSVETWHSFFSYFETREKRFTRDMPASKGKALPLLRTINTFLRTLSSTPADLQLRGRVQLFASRAISVSDKSAINMRGEYSGIRTTWEETPEETAAGADGDVEMDGGAAKGEKGEKSEDDKFYNTLWSLQQYFAHPPSLDGPATGEPAQTPFERFRSASDEVLERLFAETARERANPTPKVDRGPDAETEVVFPRYLTARALLRHELADTGFRRQVLLQYFILFQFLLNLTPGVASKQQATGGMPKSFIIDDDAARWIKSTVSRIRDELKRIDSTDGLRFEETVVELMNRERRYAQWKNDGCPEADWAIAPVPPTEGKATARKWERQSKPPRPWPYKQGTPTLTRLSETSFKGLGDFKKKTRQTVFELEEEYRRLEAEEEDDKAMGREPPENIKRRKETIRWLALRQARDTHPRVLAAMGAYDLTKLVNLMRDFDSKQAAARAKGQSEAEAEAEVAADAEGGDADADVTEAAEGDADVAEAEAAAEEPAADEAAAEKEETEPAPQVVVQESIAETDTPMDTQEQAQAQQEETLPAEQPVERTAEQTAEQQQQGDVEMAEAEEQDDEGDLGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG37</accession>
    <name>K1VG37_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG37"/>
    <dbReference type="HOGENOM" id="CLU_1836534_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG37"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="140" mass="15615" checksum="3E25E43ACDD5104C" modified="2012-11-28" version="1">MPDTVTPRSGSPFRRRSRRLPPSLIFTPIVPPPSQKQYRSKHSKEEERARLMAILKALDDDLKTQCDSLCAQIDAIIAKQEAELTARQPKRTKQTEGTAHPASTSVRMARAAPNSAASVTACDRPKTPVPRIRSVRSMIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGQ8</accession>
    <name>K1VGQ8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGQ8"/>
    <dbReference type="STRING" id="1220162.K1VGQ8"/>
    <dbReference type="eggNOG" id="ENOG502QS1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006748_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGQ8"/>
    <dbReference type="OMA" id="VPNKSIM"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="841" mass="90406" checksum="321BDC3D3E72F1F4" modified="2012-11-28" version="1">MASRYAQGGPGTTSAGAFFQNQRAPQQYKPLAGMGMNGGMNMNGAGMGAGMNGGMPQPQMQPVANGGAPRAVRQGSNGGTPRGPTPGSEGRSGSGKRMDRKDTKDTAWVHWRALKDFLSAWADKESPTLRASARDKLTRLTRLQFLELSTDVYDELMRRLSVERGGSEGAAPFLPVRDDFHPKRNQARQKLATLPKNRFKDLASDVFYELRRRYPEFDDDTSLYGGDDAQSATGGPPRSDSRSALSHDRKGSGLSSGGGGQMAQVLRAQAEEPKRFATPTAATSDIVVPNKSTITEEAIEVPYARDSVDGAADEPPATRFRTETPVSIRKNSRDEVVSPRTTEENGPGWHERDSFISNTTSRSKPIDGDAEERIRKEYELRVAGLERRCNTLEGEKEDLSRQLADERERRKDYEDEVRGLKERATTHASSLRSIQHELDVARDAHAALREQTDASARAASDEAGEWRSRAEALEDELRRLETEHANCGQGGADEAVVAELQGEVKSLVEELNALSVQNEDLVLASERHREAYSALEAQLAESRKQFQAARTELRNLKATSVMFTSQPMSEDHLPASPDGNIADMHVSAFQSAIDNLLQVARSSQPTGVLPAMKAIVEAVTAIGEDVKAFEDQPNLDVDVSKLESLKHDSTTRLGALMTAARNHAMASGLSPVGLIDAAAGTLSANVVEIIKLLKIRRTGAMREILKKRASMSIADMVRRTPFDENEERNDGAGAAGGGGGGGGVGGMSPRVSPGRFGANGSVNGYTNGSSPGSGYAPLSPKASPASPASPASRNQPLGHNNVSSLGGGKYETPAFQTLSAQPELRINSFQPLSLLVAPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGW4</accession>
    <name>K1VGW4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGW4"/>
    <dbReference type="HOGENOM" id="CLU_1723621_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGW4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="152" mass="16255" checksum="667A66110B97929A" modified="2012-11-28" version="1">MYYGGMQAPQRSTTVPPDWLSMPPPNAWNAPSVSSVGPSFTPPQQPMRYRSLTPHGGGGSYNYGSMGPPPAPAASGMVNSMPNVSGTQGYVYSEPAPVESQQTGEYYPPQQGQWNGGVDVNGAPMVTKPEDEYHGDQAVDPNNSWQQQPPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH93</accession>
    <name>K1VH93_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH93"/>
    <dbReference type="HOGENOM" id="CLU_921929_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH93"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851873" evidence="2">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="302" mass="31233" checksum="DEF5A4577D473D20" modified="2012-11-28" version="1">MKLSSAILIALASSAAAAPVAPGESMLEDPTGIVTTPLSHVIDGVMSALNGNFQFTGTRQDLQQGVQGASGLWQGVQQQAQNAQQGQQGQLTPQQQHQQAQQAKQGQQQGGILSGLFNGISGMFNGGNKPSDSPSATNLPFIGGLFQNSGSSSNTGTGSLLGNLFRVGSSTSPNSAAASVKAEGGGASADIAIKVSGFPTELSEQNLRSTLGKLNLGLNEEQTKYTIQLIQTLVAAFFSGKQIPNANDISEFIPNKVPGNLSQDQVKAINNAIYPTLNIVLKNMGTLNGIQDTIAQVLTRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHE3</accession>
    <name>K1VHE3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHE3"/>
    <dbReference type="STRING" id="1220162.K1VHE3"/>
    <dbReference type="eggNOG" id="ENOG502S5GE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692894_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHE3"/>
    <dbReference type="OMA" id="AGHEMFE"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="404" mass="46964" checksum="874F10821C8316FE" modified="2012-11-28" version="1">MSSPAWMSQVPLLPRVPLPTMTTRRWRYALVVGAVITGIVLILDAATVFSEQPLTKQYYTSAKELLTPCPEWCEVDPFRQPGMLHWSPSGADNETRWLPFPSADYEWDAQDPSSDLPHTDEIPAQAWLAAPKQYTALLERFKPTTEGEWQDWTPPRDLNWLRNRTVILIGSSHDRNNNDQMCEIIGGKKGSWGGHSGGYCYHEGLDLLVANWFLYGMIDSDDGWPHGEEHPFPFEDRFEKIMIPQMTKLGYEKRVPDLVIASSLFWDEKFLDERGRDKTVDRKSAHGFWWNELAWFRGRVRKLVETVREMWPHTPVMFRTRQLRSSVDNFHLLTIFQLDQGLRALGKELGVRLFTWGDKLEGYNVYYDNDQHFAKGPNTYLFGDMLLFYLHRAVTPGCWQCQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHG1</accession>
    <name>K1VHG1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHG1"/>
    <dbReference type="STRING" id="1220162.K1VHG1"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1511653_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHG1"/>
    <dbReference type="OMA" id="PIAIPKS"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="178" mass="19281" checksum="064233CB0893E5E0" modified="2012-11-28" version="1">MRSYAADTALPGGKYDEGDEDEVGTATAPAPTNAQIGLPIDPSRVRYLCKLDPFFAGNQLIVTPVVFLSVDREINPVLNPDEVQFLFSMPLSSFLHDRPSDIPGWNFGLSTRVKPAPIGSVPPPPAPGYAEEKGSLGGRDGRYYMYRDIEWGGGPVRMHRFLTGREGGGVKPVYGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHZ7</accession>
    <name>K1VHZ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHZ7"/>
    <dbReference type="HOGENOM" id="CLU_1422359_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHZ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="191" mass="21297" checksum="FF6752542C9DC6B6" modified="2012-11-28" version="1">MSNNSTFATKHTEWTTPPLSPRLTPPPWAEPAHLPSDIAPAGYIRTFAHPSPDGIRKFSDEQLRATHPSIAEAAIAYRDQSPEELYHVIIDQVQPNIVRLRGRYASPDLAGQDPKTKLLYGVGIGWPKEEYGSRIYLQGTPGWDRLGHWGSGNGPVTVVNCAVRHNKTYVKSAGRSRRGLRNGRGRWPWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ68</accession>
    <name>K1VJ68_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ68"/>
    <dbReference type="FunCoup" id="K1VJ68">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ68"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="InParanoid" id="K1VJ68"/>
    <dbReference type="OMA" id="HEHYSHT"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="766" mass="82564" checksum="1272DC0A245DE617" modified="2012-11-28" version="1">MARRTAGELRTREGRPATQKSRRVGGHSGSGGGSIAVLWACSALTPAGGGILGDPALNTLRHHLVHHVEPTVNPASVIRTSKRYLAFAPSAAPASSARIWPNQARWPVALLASREIEDPPVFSTPQTDIMPAVQEELKHHDVVTDVHAVNDEKKEYDDEADVRQIIGHPDQDPDTIPTAEELRTLRKVPAAMPLVGLAMCLIEFSERASYYGSQGPFNNFLLLEHAADIQAHPLPPGGNGAGAVAKGPMGEQQSAGALNQGSVTTSAVTKMFTFLAYLTPIYGGIVADNKLGRFKTICIGTFVGAIAHVILIFPALPSVIQKDPKGSLAGFIISIIVLAFAAGFIKPSLGPLLCDQSPVKAPTIKTTKKGERVVIDPQFTVSSYLNTFYLCINIGALFQLATQYAAHDIGFWLAFLLPGILYMLMPIVLVWANKRLVKLPPSGSVIPDTFRVIGMCIKKGGAFGWLKGGDKFWASARPSHLRETEGYVDESKVHWDDRFVEEVRQTISACGVFMLIPIFVISDAGSGGLGNMFNDMSVGMTKNGVPNDLLTNFNSIAIIVASPIINYFIYPFFVKIGYPIKPMMRMAIGFVLGALGCGVGAYLQDKIYKTSPCGKYASTCMVDGNAGVSPVSLWLQIPVVALPAIGEIFVNVTSYELAYTRAPPSMRGLVYSLALFNSCVAAAISMAVSSALTDPNLAIVWIVIAAVTFACAFVFPTYFRHLDDFQFEWKEDERAQVSDVKKHDLEASPRASLSAPAAAPADHEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJE9</accession>
    <name>K1VJE9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJE9"/>
    <dbReference type="HOGENOM" id="CLU_521938_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJE9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="522" mass="57847" checksum="D97C7A59EBE40DC0" modified="2012-11-28" version="1">MSTPGRTKPCSPNVSKSRTAEQIPDITIAPDSPIEPRRTPSRTNDSRSNSCYGPPAAAKGSVPPELPPGAAPPPPARPLLAPERTLSRSASLSVRPSPAGPSSRSRRRPATIFDSLSEAPSIPELVDPRRTSNPPRYSQVVSPSSSRRPREKSSWRPSDSRASDSLYDSSEADARVPKNDVPERWERPFEVNTDHDILDPVLETAAEPEASGDTSLSGSALASFLASERRRDLSLADPFSEFAGRAASPRSPRLGSPNSPRIRTPRLTSPTHLEEPQVVRTRSISSPHITFRSPEPERRPETEQRRRPKYARHGWRPSQAAAGDHLYEPPTLDDDMPAQWERPFDLHDEYEIDVHKHKAQPEPEPETPIDTSAINSFLATERRRDMGTTQWANQLQSMGDSIRADPQTAAVLTRVATRNRDHSESGRRHRRGHSRNESWDGSAILGNVDRRGNSEISRPSRQATIRAVLDPIPGAVPDCTADGREARRHARRIRQGREDHEDAPPAYMPDRPPMYVEGGTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJF2</accession>
    <name>K1VJF2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJF2"/>
    <dbReference type="STRING" id="1220162.K1VJF2"/>
    <dbReference type="eggNOG" id="KOG2069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308002_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJF2"/>
    <dbReference type="OMA" id="RYIDLWR"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="893"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="930"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="960" mass="101464" checksum="4FF254055AC9A6AC" modified="2012-11-28" version="1">MEEATGEFTGQQALHSVHRHANGPEPAPSLVDLLQSTAQDRHEPVPDFSSPAASGYLDQLLSLPLKSLLDEATVIFSEAAGVETELTNLCFREYPTFISVHKCSSAVTSAFDDFSSSLGKLLDAVPALEDECRTFVKSTKGVQDARSKALLVQEHQDKLFDLLEIPQLMDTCVRNGYYQEALELSGHATSLSKRYPGVELVQDVSKEVDAVLQVMVAQLLALLREPIKLPSLIKTVGYLRRLGSVEETELGLVFLVSRLSNFRAHQLLLEGDRGDPVRYVRKYVDLFREHVFDIISQFTTIFLESSSPSPAAASHLASFVGQCVDDLVQLVGEYVPKMTHDAASLSSILVQLGYCSLAFARVGLDFASLVTEPFNGAVSTAYAQALEEGASALSTTLKDAAKSVGSQTTLVIAGEYIPSLLAQADPVDWIKWGGSFEQLPSELSRLPPLAMLVNAHLSALNSLRLLAPLHLYPVLAGVQSASLLQCTHALAQYVRGVVALADAEKGQKAQLLRRTERELSPEERKQRRKETQWVCVALADSWIRIVCPLLANALEKGVYDGAMPAESSPELKEALDTLQAWIDDQIDNHLGGTPSPRKSREAERPPSPEKQAEKEALAPTAEVKKEEEPAPTEGDIAALDSTKPASPVKAPSPVQTPELVMETKDEPAAGEPTADAEPTPTELEAKMASVEAGEDTPKVDTPAVIAPAPAPTEEPTLNPDAAATKASDESESKLETTEAPADEPKPRDGAPAADEESTPVAQDAKTDADPIGAASTATETAAVGGTSSSGDRGPEASDAPADGAAAPATSATEKDDETSVPAAPAAPETSAAASGFADLANPSDLGQKGQDVGSAERAEPSADITAQKEDTQGAEETAEGKTSQRDIVPPPDASDSATPTAAAVNETPAEEAADEAADDDDAKDTDEPAPESTETAPQAAQAAPSTSGGGKKKKKNKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJI2</accession>
    <name>K1VJI2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJI2"/>
    <dbReference type="FunCoup" id="K1VJI2">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJI2"/>
    <dbReference type="eggNOG" id="KOG2542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_2_0_1"/>
    <dbReference type="InParanoid" id="K1VJI2"/>
    <dbReference type="OMA" id="HVVNLNA"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="691" mass="76607" checksum="9A4956AAAE38374F" modified="2012-11-28" version="1">MSSAKTLKPIHRLPLARQTLQGALSQLPLEDQPSAQRISTTFSPTTRGVWARTLPLWDNWPIRITKEEALALGCDVDKGEKISAEAILGRWDPQPGEKQDNGLELKSSPHRLKMAPVLLGVCEKTVQDCFPELDVGDAAKADAPTDVEGGDEARQALVDVLSGRKVLEGENYMPWSTRYCGHQFGVWAGQLGDGRAISVLETEGPKGREEIQLKGAGRTPFARAADGLAVLRSSVREYLGCEAVNALGIPSTRALAILTSPVRVMREQGPEPSSLVARVAPSFIRIGHFEAMNPGEAAKNSHQVFFGGGWKSSVEDEADKNDALGGQGSLEGLRDLTLWAKDVMGMKDSTVNEWFIDVVRRNAETVAQWQVYGFMHGVLNTDNISVLGLTIDYGPYAFMDVFDQNHICNHSDPGGLYSYKGQPGRVLFALDSLASSLLPILGYEAQNGKIPDAGWGENATPDDVRGWEAAGLESIESWSDLYNQIESVAERSGWQKRFGLPSYRDTDDRDIVKDFQYLLHGYDIDFGAALRQLSFFRTSKVENKEYLKSQAKLWIKQATNDLMPDIVSRTEEGIVAWLQTYAKRVNEEKDQFDEDERLKKMQEVNPRFVLRQWVLEDTIKKMEDALEKEDVPEARRVLQRVLDLSTNPFKPYGEDKDGVIADNLTGEEAEQATLCGLGPKSMLGYQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJZ4</accession>
    <name>K1VJZ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJZ4"/>
    <dbReference type="STRING" id="1220162.K1VJZ4"/>
    <dbReference type="eggNOG" id="ENOG502TANK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_998148_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJZ4"/>
    <dbReference type="OrthoDB" id="2596535at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29482" checksum="C6546BAAD3AC93CE" modified="2012-11-28" version="1">MLKQCGVSQAMREGPAHFEPSLIYSGHAQETAPAQARRSPAAEQQGPPRARKLCDPGEPAPAPAGVNRAGRGDEISTTTARTKQAKPAQPTKSTASVHQLQPPSEPGPSDAPAVSTGKVDEEPAAATTNAPKTVARSRKRTPKGGKEPLGNLSRAEVTSMRKWTVHNQVKLDPAVKRSLCSCGTVLVPGLTARVRIKPSKQHKRRLVTSCLECGSSSSIPMAKSNWMSRERAAQIEPTSEEPAQQQQGGAPETEKSGGHVMWAGGERITGWGDVSTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK64</accession>
    <name>K1VK64_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK64"/>
    <dbReference type="HOGENOM" id="CLU_1344087_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK64"/>
    <dbReference type="OrthoDB" id="2565098at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="204" mass="21830" checksum="0681B23DB5A10363" modified="2012-11-28" version="1">MAALNLTSLGAELDAIRRQRATSSSSVDTASTGTSPLTPPLLSAPLPFIADTEADDDAIRIDTPRIDTPKPQVAQVEQEKKEQPFATCLLCFQRPPSAVLLPSHEDDPEPRTDRVPFNVALARAMRKSPEKKRLGMAGFIPPELGASGAELGGKDVLSGPIRSQTGQDGQIKLESRGEGQRGVGRTQCLVCRSGVEGWLRVYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKJ1</accession>
    <name>K1VKJ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000215">
        <property type="protein sequence ID" value="EKD04655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKJ1"/>
    <dbReference type="HOGENOM" id="CLU_444225_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKJ1"/>
    <dbReference type="OMA" id="EASFECK"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="615" mass="66500" checksum="6E77446E1B57163D" modified="2012-11-28" version="1">MGSDLADLSIDSQEEMVPASLRPRPLPPSSSMRNLTQQLDSRTITEQLREREQQRELARARSLANLTRASSMRSLDARSPRVERTANAEVPISKRREQSSAAPNPGRRMSTMAPSNGQRASAASRGPLGFPRSTVPRDLALGTGPSRMSAPATSFTKRTLPPSESARRLSALPSSSSSRRLSTAPSSSTLSRRLSAVPTSSVPDTPRRQSTLTRRQSMLPPRNERAQAANERSKPSRTSTISRTESMQSVRRQSTLMTRTNSWNSQGEPEPRGGRKSILPERSERRQSVLPRSGSAQSQERESGHRLRPSSSAVIGERKSAGIPRTTTSRNLATSPVKRASAPPTSTAREALGARRSLAPAPTAGPTPSTKRHSMLPSTRSTTTLRKFAETPASKVPERREREQPQNARTRSDTTSAVSAAPSTVPSLCSAPTIDSRSSKLSAPSSEADVEWLPPLPEASFECKPAVTLTQPTPAKSVLRPKTETTSRIARRESRPNLASDLGATRGIPRSQSRESQQSGSGSERDAQRQRNTLAVSGNSRVSGASGSSAERRVSWNESLRAPIRSGHVEEMRTKYGHRTASGRSVGAEVAVDEMGRAVSGRVQASTVGSLRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKR9</accession>
    <name>K1VKR9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine beta-lyase, putative metC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKR9"/>
    <dbReference type="STRING" id="1220162.K1VKR9"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_1"/>
    <dbReference type="InParanoid" id="K1VKR9"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF80">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="391" mass="41474" checksum="A821342077ABB74A" modified="2012-11-28" version="1">MDWHPETQAVHGHAAVPMRADPVAPAIYYSSTFRAADAAEFAQMASEPRHAGFYTRYGNPTHEQAAAVLAGLEGTEVAMLTASGMGAISTAVIALLKAGDHAIAQSRHYMATAKLFDELLPRYGVKTSVVEQSDLAALEAAITPETKIIYVETPANPTLVLTDLAGVVAIAKKHGIVVLADNTFAGPLNTRPADLGVDVVLHSATKSLGGHSDITAGAICTTKALAEQMWDTSLTLGSTLSPMDAWLLLRGMRTLPLRMGRINENALALAAWLEEQPQVEAVYYPMLASHPQHDIAKKQMKGGGPVVALALKGGYDPTSRFVAALKLASQAVSLGGVETLAVHTAAMWSGSMNEEQMKTAGISPNFVRLSVGIENIEDLKRDFAQALTEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL63</accession>
    <name>K1VL63_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL63"/>
    <dbReference type="STRING" id="1220162.K1VL63"/>
    <dbReference type="eggNOG" id="ENOG502RU8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070859_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL63"/>
    <dbReference type="OMA" id="WFLAESV"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852224" evidence="1">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="29751" checksum="08A2838FA53A2180" modified="2012-11-28" version="1">MIKLAAISFLAFGRPLGRAFASSCSPLSYEVKFSLLDSALKSGQPNSEVVSTFSLKSPPQERTWAYFDTNDKGLNAEGWVIRIRHKEGQDVELTYKKRFAVPDGLDSALAEARDAGFTEDAEIDWTTTKQTLSFDHSVKLSLWTLNGTAIPSPDWGLYLLVNHIPDKIADWNHHGWGTDTLKRSRQYGPVTAKVWFGKWNDIEVRVEVLPLKNANGTGMELTTELSFGADASNASALRDEVMHELDSRGWLNREGKLKTSLVLDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLC2</accession>
    <name>K1VLC2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLC2"/>
    <dbReference type="STRING" id="1220162.K1VLC2"/>
    <dbReference type="eggNOG" id="ENOG502SCQW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322939_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLC2"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="814"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="882"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="896" mass="97909" checksum="90F9E22EA18870FC" modified="2012-11-28" version="1">MSYYGHPFIIPTYAQQQQGVSGYDLADIQNEEQTALAYLASVQRRRQAAEAAQQLAQRERQRAAAERERAIRVAQQRQAQIEAAARRERAVREAAERERQRERAMQQALQQKRQQEVARAISAERHRQAMAAAAYQRALAQHRAQAQGQRGPQTAQDRQQQQQSRAYQQQRQQVGADSGTQHHPSAATAAALTAPSGPSDDDDAGLEGINSLLGSMFGFNLAPGPEPETPQPPKRRPQQQKPRQQQQQRTPVPGDHELVSVTDFVAADYPVVLTNLLHYPSPSPSYPFNPGLILQQAQRLRDDTSAASGVEVMLQNQELLGVRAGGSSTVDLSEPPASPGYSFFGRNTPSPGPNGRARARAGVQSLAQGLFERAQKAGLDKAILSTVTDLRLTRYVVVLVLLPSEHRQRQGVSLPRGGTIGGPGAGAGAGAAYGIPREAAQPDSREAAQNEKRAASIGGAAAQVARQYDQTGSTDVPLTDAAKRVHDRDFQAHVPTQQEQIQQAARSEAKVAQIADSAAAAARELNSTGTTNIPMTQGARDHRAEERAEQERVTKEEKRESEYAATHPRVHNNQQHPDAGRQHEMAPAASAAAAGIASADNSRAVAHERAAAEQAARVAQQHQAGAQSNVPLTSAAQQQRNDQTAAQQAAQVARDERASGLTNVPLTGAAQIQQQDERAASQAAHAARDLHRTGHTNVPTTHAAQRAAEEERLAALERKKAKKDRQRQKKQALRQRAEQERAAHGAAAAGLDDLNSPDAQQALGQLKAIDDKFRHLNSEFKFPHQLNFGPSNADQTQPPLLFDRNNTPYHAQAHSLLQLLLECDGVQSEGNRAIRQKRKEMVRRIEDELQMLENERDRQWRIVKQRREEGESDEDSDDESDSSWWYGGDSSSAAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLH5</accession>
    <name>K1VLH5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLH5"/>
    <dbReference type="STRING" id="1220162.K1VLH5"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="K1VLH5"/>
    <dbReference type="OMA" id="MGWSIAN"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="497" mass="55782" checksum="08C11CBCC869F9BE" modified="2012-11-28" version="1">MPSSTNSKEEIRHIESHHEKDYLDTVPHMEGVIASGDDVDIDEGFDPAFVKRTMRKVDWRLIPILSLMYLVSAMDRANLSLARAANQKQMDRDLGLDIGNRYSIATLAFFIPYIILEVPSQAGLRVFGAKIWLGGATLLWGVMMLCMGFVKTWQQLTALRALLGVFEATLFPGAAYLVSCWYPRRKMASRMTYFFIGAMFLQSFSGILSWGISHLHGRNGLHGWQWIFIIYGILTIAIGIGAVILIVDFPDKASFLTEEQRLMVTTRIERDRRDAVYDKLTVAKVVHHLLDWRIWMFGLFFCAAAMVIYALAYFLPQILAGMGFDNKMSQILTTPPSIYSAIPAVIFAKLADRYKLRMHMVSLNAIITITGICMFSQLGKNQLAARYVGVFLATGGCQASIPLITSWSQTCIRSQSKRAVMSATVVAWGGIGGILASVTFMQKEAIKGYPTGIWLTVGLSAFAAVGAFLMWCWFMYQNKRADRGETVIEHDPDFRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMB5</accession>
    <name>K1VMB5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMB5"/>
    <dbReference type="STRING" id="1220162.K1VMB5"/>
    <dbReference type="eggNOG" id="ENOG502SC4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802124_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMB5"/>
    <dbReference type="OMA" id="LTCIYTY"/>
    <dbReference type="OrthoDB" id="3216420at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="2">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="346" mass="39408" checksum="5C594D96311FFAA3" modified="2012-11-28" version="1">MSGTKVAKRGKENAPPKTDPAIDDAGSSTSFGKDTAADSSFRRVFETESKQASQILERRWQRRTGWTRGPERDRLKKERDAFAKQLEELSRLRQTEQEIIFERYKKEADERAKLQAEMIETATALDEKRVSKISELEKLVKEQREALGKAHDRLEAAAAAPSLDSKIDGKGVKDLREEVYKLRKVVKERDEQVDLEAEIQHTQQLQEAASKAPAPAAPPPAEDSEKDALSLGLYEDLSGLAILGVSVKKTQKGRDVTFKCMQTYEDRTLAFKLRSFNEFDREANKWVKNVALIPENLHNETDKAFVKRLGPFAKGFCISRDQLPAAWEQLRSRMSREGQYRDPEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMV7</accession>
    <name>K1VMV7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMV7"/>
    <dbReference type="STRING" id="1220162.K1VMV7"/>
    <dbReference type="eggNOG" id="ENOG502QRPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036729_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMV7"/>
    <dbReference type="OMA" id="ERRAYCM"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="351" mass="38337" checksum="6A99C7DDBC6579FE" modified="2012-11-28" version="1">MTTSSSSSKSFEPYWLQAEDWHTAGEPFRIVRPPASMLPESIPSVADFRHQVASQGNHPLNTLRKTLCLEPRGHADMYGCFLLPANEGAHFGVLFWHKDGFSTACGHGTIALGSWAVHHHIVEPKEGLNEVIIDVPSGRVKADVHMKDGKVEYTDFVSVPSYVLKRDVSVLDTKVDLAFAGAVYATMPSPLVVRPENHEALISFARQIKASLAPNDMRIYGDYDLYGVIFYEDLPPNSRAEAKGVGDAVRQRNVTIFADGELDRSPCGSGTAARVASLLAEGKMKEGSVLIHESIVGTTFRATIDKPAESPTDFPGCVARVRGRANLVAKSEFYIDPEDPVYPGFCFSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN03</accession>
    <name>K1VN03_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN03"/>
    <dbReference type="STRING" id="1220162.K1VN03"/>
    <dbReference type="HOGENOM" id="CLU_774312_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN03"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="196"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="39801" checksum="6914CB750748C3D9" modified="2012-11-28" version="1">MAFFHLLLKCYELGTCSQIRDSRAFSLPRRVLCAFDLLINLRLFGLGAQLETPIEARGSRSSRARPERHLSHLYRLVPPSRLDAVIGHAFDAWLGYAIASLVISVIRFACGAVQSSGPYDVWSLQGGAGALGHESVFMPDGEAMTAHNGWGPLMVFCARSFLIPFLAVQLLTAIYHLCATFFVATRLWSVEGWAIDLFSNPGAADSLLNFWSRRWHQVLRHDFLILASLLDPFAPSLFRVCLPFGASAVLHALMGLNSTTPPDPAKQLTFFAIHGLGCLIELSYNRIKGKRVHGFWGRIWFLTIMGLTANVSGGAWTDAGWGVIVDWIFPPGGTGDKVVLRGVEYARRYIHNWRMKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNA7</accession>
    <name>K1VNA7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000033">
        <property type="protein sequence ID" value="EKD05670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNA7"/>
    <dbReference type="HOGENOM" id="CLU_1518917_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNA7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="18277" checksum="5D4A945C9C8C34C7" modified="2012-11-28" version="1">MTSSFELADIHRILTVIDLDDDEPFAAGEDNASGVGHDAADDNASGVSHDAGDDNSSGADIDAGAGNAANLEDAENGIAGGEEGGEAGEGTADGAPVWWRRFIVCSELRPQAVAGFLVGIVLVLVVYIPGLYPPLKVGCAAAAPPVANYIAAKKDRWWLFYIAVLTFVGGFVAKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNK9</accession>
    <name>K1VNK9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNK9"/>
    <dbReference type="FunCoup" id="K1VNK9">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNK9"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072366_1_2_1"/>
    <dbReference type="InParanoid" id="K1VNK9"/>
    <dbReference type="OMA" id="EYVFNVF"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="188" mass="22044" checksum="A2D6E5D53334AA05" modified="2012-11-28" version="1">MGKSQSKLSADELAELQKNTYFDKKELQQWGFLKDCPSGQLNKDEFKKIYRQFFPFGDPSQFADYVFNVFDEDKSGTIEFKEFICALSVTSRGRLDEKLKWAFQLYDINQDGFITYDEMLQIVRSIYKMTGQMVSLPEDEDTPEKRVDKIFRNMDLNKDHRLTFDEFKEGSKQDPTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPA0</accession>
    <name>K1VPA0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPA0"/>
    <dbReference type="FunCoup" id="K1VPA0">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPA0"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="K1VPA0"/>
    <dbReference type="OMA" id="YEMMAIP"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="563" mass="61685" checksum="66590B6D394CA63F" modified="2012-11-28" version="1">MTNGIERVEAPVTWKAYMACAFAAFGGIFFGFDSGYISGVLAMDYVKEHFRPKSSGPYPTDPNAPDKAKDLPSWVRSLITSILSAGTFFGALVAGDLADYFGRRITIIAGCGVFIVGIILQTASTGWQLLVAGRAIAGIGVGFVSAIIILYMSEIAPRKVRGALVSGYQFCITIGLLLASCVDYGTKDRNDTGSYRIPIAIQFLWALILGGGIAMLPESPRWYVKRGRPDDAAKALSRIRGQPINSDYIREEVAEIVANYEYERSLMPTESYWAGWAYCFKGGLGRSNSNLRLTILGTSIQMMQQWTGINFIFYYGTEFFKNLGTISNPFLISLITTLVNVCTTPISFYTIERYGRRALLIYGAIGMTICEFIVAIMGVAKPAVVDPITNVARPEDKPIASAQIAFICIYIAFFATTWGPGAWVVIGEIFPIPIRARGVALSTASNWLWNCIIAVITPYMVDRDKGNLGSKVFFIWGSLCATCVVYAYFMVWETKGLTLEQVDQMMEEVRVPWRSKGWKPSTTFAAHGHDAIDQKVDGEKLDHPQEAYPVANQAPMGGAAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPM6</accession>
    <name>K1VPM6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPM6"/>
    <dbReference type="HOGENOM" id="CLU_1240901_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPM6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="223" mass="23519" checksum="32C218D26660648D" modified="2012-11-28" version="1">MQCRETPQCFTESTETRQVSDLATLSEVGQDRATGTAERIERNVEGSEEGQQNGIVIGGAIFVRSSRALTALGALAWTDAFRGPEEILKGVVEYVLDDSRGIEGVGSAADPKSSPPESNLESSVSWAMDGPGNPDPQALRLDEPRDPPVPQALDERDPGTGLQDQRRIPVVSGSVTLQAPALTSEHALHVLAALRLNARSLTPPSPPSLDTSSSAADLTLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQC1</accession>
    <name>K1VQC1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQC1"/>
    <dbReference type="HOGENOM" id="CLU_483279_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQC1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="613" mass="66272" checksum="D08A216BFF189C9A" modified="2012-11-28" version="1">MNGGGGASAGPSAHPASPNGTPHPQLNPFLTTSAPASFPQKSTSPSTHHVSPPKATTASKTYSAEEVWLIGRERLRPIARLCGVRVGDDTCDAELITDHLHSKIEAMVTENPHAPLPHVWLSGIRVRWDNFQELRDAFDNHAYRNCLCAVEKAHYKNNHSPTEFREDQLRPRLELTPGVPPPLPPLPEYLPSYEVTTHEIRPFCDRPLPAIPTPGPRLRELREDIVEVRDVDDVPSMHPAALWDSSDFVSMELEDDDEGTVIGQVDGAPVIRLSAPPPTPLQGGRMRKRGERADSTFSDASWAPSVAPSSPISARTAPPRASASSSQPVIKEETPFNVRGGTPTPSTPSKRSLRQTPSLEQPILIPPAPRKRAKPIFAKNQILLTTVPLPDGPLPIPSASAQGAQPMRLVKKSGRPREIPQPLDYILARAEAAHKAKAATVADAAAVVDYIKQEISAPSTPAAPSLPPSSQLTATQTSSQVSLPGPSQSSQASQMLPPPTLPTNPRRMPARGKRKEPSRDDAEVVSRAAEEWAYAKTGRYYGISFWEHKMAFEKAAEERRLAALGGGLFGPPLATVAPASQQPTTQYPPPPYPPPQYPAASSQYPVITPRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQW2</accession>
    <name>K1VQW2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQW2"/>
    <dbReference type="eggNOG" id="ENOG502SBFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035170_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQW2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852384" description="VWFA domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="391"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="593" mass="59690" checksum="CEA1E4C1077C9FEB" modified="2012-11-28" version="1">MRFVAGFSLLVAAVSALPALPRAQQQVCDNPGRFVSVVIDASGSQADNDPNNVRLKGAQQIIASLTPEGSATAANKADEIAVVSFTTSADVLYPLGNPGSEASDVAASVSANGGTDVYLGLKAGLDQIARVGSSQLDRAGVVMFTDGLDDGVVGATEWERKRQRLQVVAKAKAAGVRVSWGHLSFPKTSTHGGGLLSDIWNIIFGGGVGRTTTTIAGPELDKELAAAVLATGGTVSVISSADAQISFVEQVLKNGITNNDGRCHGLDIDQSGGPVKNNVTSLGLCSDNANAVFTYTPSHSKEKLAVTIDLLSTANHVNLHATLENKSTGSKLKVTVDSASPTQILTAEAAPGENVEITIQPSGASADTCQYGVRLDAVPIDTIPTSWQTVSSSSSNAPLPSSSHDSSPTSSSTPPTSPDAHPSSSSNSPPPTSSNNSSSTSSSAFPTSDGPPSTSSKAPPPTSSNTHSSSTSQAPPPTSSAPPISSVPPPSSSTATSSTQQSSNSSASPTSISAAPTSQGPRPTSTPECPTAAIPSVTVTATATVVQTMTATTTATATATSVQTVTATASTTGSICLCKCDAPGVQPLAKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR62</accession>
    <name>K1VR62_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_06407</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR62"/>
    <dbReference type="FunCoup" id="K1VR62">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VR62"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR62"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="334"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
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        <location>
            <position position="337"/>
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        <ligand>
            <name>substrate</name>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="422"/>
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            <name>thiamine diphosphate</name>
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        </ligand>
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        <location>
            <position position="446"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="454"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="458"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="505"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC99207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="669" mass="73132" checksum="6D8B9AFB3B5A8C07" modified="2012-11-28" version="1">MSSFSDIDTKAVNTIRTLAADVVAKGMAPVAYVLWTRYMNYNPKDPKCCALQYVLLHLTGYDVSMEDLKSFRQLDSKTPGHPEVDHTPGIEVTTGPLGQGISNAVGLAIAQAHQGAVFNKDGFDLINNKTYVFLGDGCLQEGVASEACSLAGHLQLNNLIAIWDDNRITIDGDTDVSFTEDVEGRFRAYGWDVLHVDAGDTDLDAISGAIAQARDCQTKPTIINLRTTIGYGSLKQGGHDVHGSPLKADDIKQLKEKWGFNPDESFVIPQDVQAVFDKVRDKGEQKERDWDALFKKYQEKYPEDAAELLRRVSGRLPEGWEKHLPTYTPDQPAIASRKLSETVLNAIAPVIPELIGGSADLTGSNLTRWKGAEDFQPPSSGLGSYKGRYIRYGVREHGMVAISNGIAAYGGLIPFDATFLNFVSYAAGAVRLSALSKLRVINIATHDSIGLGEDGPTHQPVETAAWLRATPNMQFWRPADGNETSASYYAAISSAHTPSTLALSRQNLPQLKGSSVDKARKGGYVLEEEDKADITIVSTGSEVSIVVDAAKILREKGLKVRISSLPCFEVFDEQPKEYRLSVLPSGAPIMAVEAYNTLPWYKYAQEAVGLRAWGASAPYQDAYKKFGLTPEGIASNAQKVVDFYKKRGGDIFSPVDTALNYNTELEYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR63</accession>
    <name>K1VR63_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR63"/>
    <dbReference type="STRING" id="1220162.K1VR63"/>
    <dbReference type="eggNOG" id="ENOG502S4UR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="InParanoid" id="K1VR63"/>
    <dbReference type="OMA" id="ANIWSKL"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="66"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="404" mass="44102" checksum="6B404658FF515AD3" modified="2012-11-28" version="1">MTVDRFPEPKLKSPDALDTLLRERVAKRDLPAIFLGATNADETIYLNQAGERVFGNAAAGEVNEDTLTSVACLQLVDQGLATLDDPALIRKHLPELDGIPILEGYEDGKPVLVPSTNPVTLRNLLSHTFGSILPIISPLMTRYFEDAGCHNLFAPGTKVSDMVTPLVFNPGEGWSYGYCIDWAGVLVERISGLRLDEYFERNIWAPLGIKHMECFPTDEVKAKKMWVCIRNEAGEPQVMPTGFGLGRAERPEDVGVVLGGGALYGSQKEYLAFLRGILRSDPRYQGSGHALLSPKSYAELFTPSVAPDHPGMPTLVGMVNGWIPFEPATEHTLSHSVGFALSLADKPGRRRAGSGFWGGACKTNYWIDPATGLAGVAGTSLRNGQDPWERFNIEFERVLYASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRQ9</accession>
    <name>K1VRQ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRQ9"/>
    <dbReference type="STRING" id="1220162.K1VRQ9"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015435_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRQ9"/>
    <dbReference type="OMA" id="LIRHYCD"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="782" mass="83510" checksum="25431DAABF2F4BD2" modified="2012-11-28" version="1">MVEVYDHYSSGASHISSPELARMLPDGQYWPNRAGYPEWGYNVNQAAPYPAPSSLDGVSPPPAVPLDFGVPTSLPPPSTASSSSSYMAAPILPSLTSPPTMAPLPGPSVPPMHSAHSMLPDPYQLGGYPTEQPQQPKPSGRLGVKRRQKYTRTRTGCLTCRARRIKCDGARPSCRKCNVAKRECKFPHPDEISRKGKSKDNKAPAAPPSTASSHASSNAGQSPPYQGNSPVGSSSSSGQTAKFDIASAFPEGFDFAGTPLGWDRASSAAAVGTFLEAALMDSLRTRTVPPASDQNAQAAAREAWLSSPIFTTPNFLAPWFPTQQEQSLILHYCANAADLMMAIPTAFNPMMAINLPMALNMPRGADAATDALRISLLATGAVHQAFLLARSNANATQTSAMFQYAANLRDAAKSMIRSAPGNTSEAALSACTSLASLDILFGGTGWTDNFDLAKAIVANRGGPAKLLELILEVLTIYETLGCLTTGREPELLTEENAEWWFQKPVNSPMSPTAHNFEHYSVENQFGVSKVIVHLLNGVARLLARIERYNRGEPLPELSANATTSPTNPLAASITMPTGFLGFDSGPSSVSSSTVSSNGPTPLPADQRPSFDRAGSSASSVSGPHTKELARTAKTLLADVNLWIDNLTNSPNEIHERVQVGNQAYAYTMKILILTSAFGIPKDSPIIQEAAEQVLQNCSFSTAALGMSLDLMWPAIVAGSCFAPGNSRQWLTTLFEGFKSQCCFDVDTASTIINEVWRRSDAGLPRADWKPVCDDFGLQVLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS31</accession>
    <name>K1VS31_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000252">
        <property type="protein sequence ID" value="EKD03406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257614_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS31"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1352" mass="148333" checksum="8A1186DB7AD4195E" modified="2012-11-28" version="1">MYTFGNQSAVFNFTGTSLHFNVEYASVNQTGAASGPGGSSSSNLFWHTRLVINGTEIGNDASALGTDDLPNGQHYVELQFTRLDGNATRDSYAMLRSVTGSLAQEPGPNAWNQTFDDSMRNSSVVLNDGWSRLSADTDNHPETITNETLAAAEEPQLAQSWEGTLAVAEHPGAAAQLSFTGSAVWVYGPSGGPFGEYMVQLDGKDVGHYGAMGGNTAYQTLLYHTSGLREGLHRLKLTSINGRIGFDRMVSSNGLVTLSAPKQAYGTLAVPTTTVGATTHGFIPMKNTDKPTAAASKSKSSTTTAIAASVGTIGGLIVLTLLGFLIWTCCVRKRRRENRSNRPAQYLPEEPGRWYLPGADSTAPEGGSELDDEPATGRRVTRASTRAATKAAELRRATTVRRKARTDGKGYQSPFPTLASPQSATSASSNIKAPETEQEPAQSTADDDEPVLFNLAPNHTSSPDFSSGQGTGLPVLSHDLPAAEKSKADTYPPFRQMQIFRQYIAGTRLVSINLISAQTHYCRDEDVIRNLCERFCEPVSTNELVLAFPRSWLGYRNMGSLEVELLLTDTSTDDITQAKFKSEDIRLTAYHPGSRLESFHFGYADLNKTERAHWRYFVGWVQEMAEAEFPPNRATPDFSVSVRRVQPRGDQLAAVGGQTEAKRECGGHTLLRSYCTMEARFEGGLNLAKRSFISSCAKSHKASPDGISLLGSSPPRPSADPPAMSEGLPATLAALNKLVAQIKGYMTAMPASDRFLSPVIDWHHPQDYDQTTIQGLSKFLHHVEKEQAIIESVSFPTPSDPRKAGAGCFSDSAESEPQAERKLTPRVLLADLQLCKPASQPAEYTSNLISLEGVWGAFLRAPKPVTAIWQAIYKVPGFENGNGSMKIDVVGDGGGEWIKVSTRIKESRLLDEFREQDSYINSDWESDSSDTAPNLTNSLLTNARILAAAAAQYPRTPGLAPPRLRYILTRLPATGHSDSRIGETITEMQRLGIHVDFCDSQWAIPEPRHIPPLQPAEDIVLDVSIMIALCCDSTHHPLPADEYELESRFRTMKLASSPEGSDGPADNRLVLGNYTNATRDLRDQLRCEIRRPLITEMIHRLNGRTVRFWITREVRDRLPKLVDVIGGERERYRAQAMFNANNFWAGSRWEGKVSENLRDFRVRVLEDEPSWTAEGVSPQHERILSTPFDSAVAHVCREMLSSSEDTPTETPATGYPPDTDGQAMQHRPTGKPKNMRVSRNPQRARVGTRFTNSKLPSGHTLRTLLAGIAGGMTVLTNNRGAVLKVLREEGVIEGIPFAYAEEGTKEDGQDAHRARIWIVNPSSLAEWRRCQVEKANTELIEQYPGARIERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS90</accession>
    <name>K1VS90_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS90"/>
    <dbReference type="STRING" id="1220162.K1VS90"/>
    <dbReference type="eggNOG" id="KOG4546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036533_2_0_1"/>
    <dbReference type="InParanoid" id="K1VS90"/>
    <dbReference type="OMA" id="TPQREFD"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="387" mass="43837" checksum="A54A6E681D153918" modified="2012-11-28" version="1">MASHLVDAYEKLLVDNISTVNTVESTIRNVTWFLPGRFADADVASEGLYALLSLVSSGHDALLEKRIPPSLSLPPHPFAPEPAVQESLFGAPPPASRVQPLLPPASEHRRYTRYWTDKSKVYRRASRTLQTVTYIELLLEMLIRRKLGDRARWRLVLSIEAFKSILRFILLLVTRRPVLTPPTPQREFDPAMIPQEKLKSQPPAALGKKMEDARPVIPEIGHRQPLRAHLYPLVASLPEAYQMHPLGLVPELCTAKEWLSEVLNSTTGLVQVLLFYYAMRNPKSKYRPASLPTLSTYFYPFLIPLAMQLVSRHFRAPTGDSTLLAEHYAKLDRRLATRFFLTGPMWVGWTRPKVMAVVRGLQRIPLIGLAGGLLEGYLPLVDEYYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSB4</accession>
    <name>K1VSB4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSB4"/>
    <dbReference type="FunCoup" id="K1VSB4">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSB4"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSB4"/>
    <dbReference type="OMA" id="HATWPKI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="318" mass="35190" checksum="216DFB7E36D3B355" modified="2012-11-28" version="1">MPKQNGRPTDSPEVRASKTLAYILRHGAEKEGLAIRSDGLVKLADVMARPKVKDIDESTIFRLVADNSKKRFALVWGYDPSPPKPKKRSQPKKTKTAAIAESGAVEEVTRALQVISVEPEWKELEFIKLSPPLSAFPDPELVAAYEGGEVDGQSDERAEWFIRAVQGHTLKLDSGHLEELIDDENGRQKAGLLVHGTKWQLWDTISALDTQAPADSSGDTGLNKMQRQHIHLAPALTGRITPRNQSSLLVYLDMPKMLAAGIPVYVAQNGVVLTPGKEGVVTNHFFRKVVSINRDKRRVIWENGAPSDRDEQPDEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSQ8</accession>
    <name>K1VSQ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSQ8"/>
    <dbReference type="HOGENOM" id="CLU_053750_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSQ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="497" mass="57818" checksum="9AAF4D466E6E54E0" modified="2012-11-28" version="1">MARTRSRSATPTHSNPNKKPRPNPERAHPRPFDIQAFPHILEAVIDAASPEVLRALRATCREIFRDINRRERHLSLEQMPEIWPPKGDELSYVDLTEEEREKRLPQPVWSMTPSGVRRAWLPDETDVLDIDGWVSRLWLEIIEPNMGLWDKDGEDIYGYNTEDGTDSDEDPEYQFGMRRVPLNEHEREIRRWLRRNEELFYDRFNPRLVRYPDGFGDDRKAIGPLKPDPCAVYFCDFGDFLLGLYHLDSHYSDWAGVRGAYLDTVFNVKLVGDHWSKDPWNHMDPANGYDVILRSNALTMLFEMTPEFVESVEDHWDEPRFLVGLLKLVTRNFMVIDEEDEGRPGEGKATIVGYDTWPLCVLPDPSERDGAGPPANAAECVRRWVAIHVADVKEEAQEKGLKLTRPEDELNDPIRLLSLDEWRQEIGEEYFKLMTDKKYQYESKKPLPPFKRHPSVEPLSLIGHHNAGDRWIFADGLHTLESKVDLANVKKVVQCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTC8</accession>
    <name>K1VTC8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTC8"/>
    <dbReference type="FunCoup" id="K1VTC8">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTC8"/>
    <dbReference type="eggNOG" id="KOG0718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019611_0_1_1"/>
    <dbReference type="InParanoid" id="K1VTC8"/>
    <dbReference type="OMA" id="QLDKHTM"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="571" mass="63796" checksum="7F6D26A0CF6B5E7E" modified="2012-11-28" version="1">MDEPGPSSEYYRRFAAREDGPILPPQMHQDPFINPSETPVQFLDNQANDGLYAILNVDRDASPNEIKDRYRSLAARYHPDKQPDDQRRLAAHQQFQNIQRAYEVLTDPGRRTVYDMFGEEGLRTSWEVGPKNMSASQMRSFFLRQGEAKRQLDAEQLVNSKILGKHSWETPINENTQLAIEGVMAARGHNGGANISGTIKHQFSPRFWGQYTQAFLAPRIATAKGTYTFDENTYVTGQAFVQTLAGPPRLSMSLGRRLYAFTTGFITYNTGFWDLGPWGRNMDPRLKFADQSSMMVGMTNAMNNGSGWTCQLQTGHAENGIAADWTTNVMGLRVKLGGQLDVTGELTAFADAMGRVTEYTRAGATLQLATSGVQLKLYLRRLGQKITIPILLSADLNPYVVLGTAVLPAVSWAAAYHFYVLPKKQRDVKNRIKELREEHAEYIAQKRQEAENAVLLMGRNAASLAAKEKERGGLVILSAQYGPASAFSARGVSDDEAVIDVTIPLQALVQNSKLYIPGGRNKFNLMGFWDPCIGEKKRLRVRYLFRDVVHEVEVDDVSQLRAPVKAHALDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTL4</accession>
    <name>K1VTL4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTL4"/>
    <dbReference type="HOGENOM" id="CLU_1628222_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTL4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03911.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
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    </evidence>
    <sequence length="163" mass="18036" checksum="22F0F310ACB1EDAC" modified="2012-11-28" version="1">MDDDDPPTPELPSVPEPSQKEVSGDSPTQAESPTEPEVVRPRQQSSPPSPPPSRTVVTRRRSPLPVDESDDEVVMIGESPAPPSYKRLRASAPQQERRVIPRNGTRASPYSVPDTPLRELSRTVSPPTSGSRRTLPRRPSSQSALPEEVRYRLARKLHDPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU09</accession>
    <name>K1VU09_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU09"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000805_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU09"/>
    <dbReference type="OMA" id="WHENEIG"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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            <begin position="1891"/>
            <end position="2244"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <sequence length="2543" mass="272441" checksum="2CB64029D194EC31" modified="2012-11-28" version="1">MSGVFHLDEDREREPASSTTAPSPSSRRSSPPHQSQPSTVRTSAASPPALQVPASGLPQSQPFGRKSAAFATTPSFSSPLAQAVTVASHTDSSSSSASSTECSPHPSDDEGSIASGAASAIESPLLTTSGGRPSGPPDPAPPRRSYSRPPSPSQTRQGTTPGSSLKSRVRRSGSMSLSSGSAIASRGSPPTSANNPSSSRRVDMWSDVASQKSHHSSMSGSSGRGTASETGGGGSSPLAFGSPELEATVDLLTVPPPIAVVSPTPSRSRDSNILGLGWASGWGNPNAAPSVSKGKGKSKDSSRPASPKKEAEVTAPGPSSDAASTRIRIYAIVFRRLALSSSASLISPLDPLPSPWSETPGSLAGVVAEHGSGTSLSRSVTGASIRLNRVPTSVRLAADLIKTQSTPPPHHNSSDSSTSVPTPNPSPAETDKGISGLPPRKLALPASASLPPGALNAALSSSPSASSRWNSLDATTDASSFSSMSSPTSAAPHHASPSSAGVSPTTPAHASQGSRASTLEAMLSRRSSPVAVLSPSSATGSSSMAEEASSAGLGSSPTNHLDGVGPSRLRAASEKGGLTMDLAGVSAIGDAASHANLIMQSRQAKMQRWRPRGRRESSAADSRWFTCKPSQRLWAVDSPGPRHRPHAEHREVPHSHSSHLGIDSFQPKFGSVRMEKQVSATGSVASIEWVDWYDEYKAYKAEKIRAEAQAASERQWSQPVSPIVGPSYLEETTLDPSASTATLTVAAEPPPTSYAQKGEPTQQQESGMHRRRSLSLRSAISAMDQKRSPNPKRSGLLDRPRQTSGGSTRSASGDTHLSLRRKKNLVSKMEGWWNAVKSNFSADAEIDTQPSSGPSAYSHPRVPSAPQSRRGSDKSSSTFLVSSLHPPEPVRRSSSTSMRSVRPSTSHMDLPRGEVSAAGGGSGIAPASAVEPIVPVAPLAEPAPAVVHKAGIKQIERHAIGLETRRNQPSLRLDLEPNHLVLSGSRHRGSSYMSGSNDSRGSTMPSGSVAISHTANSRSSSYGFGQSLSASSQWEQSPSPLLPALSTRETKDDKPVAPGADLTVASVRRHVKQRLNAAKEQCDSTLKKIIGTITIYVDQRMTATEDIEDPRQDYFDTFADSPSLDPADSEDDWNIPPIGGSNRRGSMSMSTSAIISSPSRRMNALSSVPSSPRKSMSRRRPSIVPRREHRGLSADQPSACSSRSTSRSRSPMPHMRGSGHAHQGFDGPADADRLFLTSLQDLIVLATDVLDLTVDSLISRPSACVEIVRKIQGTGQAWDEHEDWPGRAWYVDILMAVARLARVLEWWEAEKGFWNFDEDADEPLSLLLRPTRDIPQFELEPGRSDFEPPQVFSAASTDIEQDLSQSATTVTLAHSQAIGSPAMSAVDAKERANLDDTTQAIEDLRILAEEAQMVNIVMELSLQGEEIIYVNDAIYEVIGNTVELRFRFEAHKVDGSPDEREPGPSYMELEGVGMLIRENNEPSHTMWVMKPVTATQVEKITDAVFPRDGVISTESVLCRICEREIVVWFFEKHNETCDAVHRLDAEIDQANECLCELVRTVNKLKADLTVNDLRPASAVRPIVFYQIPESISSESEPEDAQGVDGTKVDVAQLQAVIDILLAAKKIETPSVLDSEVDMPFNLQRYISAESEEKLLRITRWQKPPTTDSGLARLFTLIEEQLRQKQKAVARMQSTIRYSEKIRHEWEDKINQMITDSEDASGSDSGSDALDASAGSTEVAANTPQEAPGLRAPAVRLPITQGHPQRVAQDVPTQRLAKAGAAPIAPSVLQDSQSEEDLRSTNSPGEAASSATDRPSTPQHMSNLTRLRREGLSGSPDASRSRSRPLERGDQRGHTRRVSSVRAIREGPVSPYLAASGSTIATKAPAPSIKDFEIIKPISRGAFGSVYLAKKVATGDYYAIKALKKSDMIAKNQITNVKAERTILMNQASSPYVVKLYFSFQSKEYLYLVMEYLNGGDCATLVKTLGALPLDWARNYIGELVLGLEYLHGRNVAHRDIKPDNMLIDSHGHLKLTDFGLSKMGLLNRQIGGPRPPYLRGTSLRTVVTTRSSMSSNDSPLLSPETIPVPSASQSGVSYFPQLADSPSADDSSGSESNGPIPRHMRHRSSAKGSSDAGTNSGAEPPRFVGTPDYLAPESILGGSTDDRMVDWWAVGVVLYEFLYGVPPFHAESPEKVFDNVVSRRINWHEDEVDIPPDAHDLMDRLMCSNPAQRLGARGADEVKAHCFFEGIDFATLTSTEAVFVPNAADPESTDYFDPRGANTLPDQEHSAVLPPLATPPAVDPPLNSDPALATDQPEQADDFGAFNFKNLPVLKQANDDVIRRIRSDSIAALGQPAEVKDRLRGHHVGRKASTRGRGPPSPSTSTSSAASTPSRAELNALERVKLMDHDSLRHHPSNRFRAGSGSSASDWSSNMEAWTHPRRPNTEEGQLVPAANPSHPAGKSLVVLVAEDNPISQMTLLSRLGCRCVCVQDGPEALAAAMGSISGENVAFNDQHQPEHTHLLCDTTQTVLKGRAPSVPRQSRLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUB2</accession>
    <name>K1VUB2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_01566</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUB2"/>
    <dbReference type="FunCoup" id="K1VUB2">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUB2"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="K1VUB2"/>
    <dbReference type="OMA" id="WDITEFI"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="132"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="244"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKD04091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="630" mass="67476" checksum="CEFA47A9FC50B04C" modified="2012-11-28" version="1">MRYPAVGPVRHSAVPMDRVTPTRHSLRYYVLPRVFGRPLLTIQHHVQSRADTTTPPRRAAGPPRSATALLPTHPAELRHRRRPLVIVQNAGQGQARRAPLLRCSLGGGIYVASRPPSRPTPPLHPNSSKGGKKLIPLSEVAKHNQPGDLWIVINGRVLDLSNYAGQHPGGTAILQTWAGKDASALFNAIHSPGIVEERLLSQQPGAYIGDIDPSTLPTPSHSGSSVSAGSSATAGSAPVADHEITLDEIIGLPDLDAAAEQRMSPKGWAYISAGATDMSSLAANRQAFNEIWFRPRVLVDVKDVDTSTSFLGSPSSVPFFIAPTGMSKLAGPEGEPGLATVAGKEGLVQFISTNSSAPLDKILEGRSADDQVQFFQLYVDKNRDNSEKLLKRCNEHPGVRAVFVTVDCPAPGKREADERVRTTAVLESGTSGGVVQADKRGGGVGRTTGQYIDPKLNWDDLRWLRSQTPMPIGVKGVQSVEDAIRCADAGVDAIYLSNHGGRALDGSPPALYTLLELRKLRPDVFDKCEVYIDGGVRRGTDIVKALCLGARGVGLGRPFLYALSFGQDGVHHAVDILKDEVETTMRLLGVNKLSELGPHLVNTKALEGKIATELAYGPNEEKSTSAPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUC7</accession>
    <name>K1VUC7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">STE/STE11/cdc15 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_05332</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUC7"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238947_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUC7"/>
    <dbReference type="OMA" id="SQRIFAN"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="538"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1157"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="1524"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="658"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1589"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1628"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1668"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1682"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1703"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1732"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD00363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1766" mass="190486" checksum="BD1BD4218A8242C6" modified="2012-11-28" version="1">MLAASTQPQPPHLLVTPSSTTDSREQQQMSTNTADAGVRPPPIPPRRMKSLWRKPSKLMNDDQPVASSSTSDLPLPNVKAASSSNLLSAFSSSSVDLPQTSTLVNPSATSSAASTQSARSKLKNFITEPASQAVRALGGGPGKRSSVPQPTRSIPNLREQHDQHKNYAARANTIARSSTTNVSATPSKVPRSSIPVRTSSITTPTAPLPPTVSTPSPSPPRKTDLGRSLLKASRSTPSLPRRAKKGKGKDLLDDDDEDEKPATVGKKKKGGRHSLAMLFHKNRSTSAVSPHSSETPSPSDIDLTSPEDELKPIEKLPPSILSQPKRSTLSPPITPTSSYFLNNSRPSSGSNSAAGSVGLPDLSPATTRGLSRPSSSSLSRPPSQSALRGSNGEPSSLRGSAQTLQNTVYRHNPSASSLSPAGYSLSSSSFQHSRSSLINGSHTSLSLSQTSLILPDGPRHSLLSQEHYHLRFACTYITYLLTPALRHANFSTSERNLEIKRISEDRLGHLARMERSWGSSWAEASGEILSGKQSGVSLEVKEAKLRACNITATAKAHERKVFVSAVRDGILLCFLFNRLFPSQPAHIQRVKVPRDEARIRANIDRFLSACSEIGVSENDSFTMADLDEHSPAGLARVARTILVLARMSGSAVVLPAKKSKRNLRGEGSVNKSSIPKVRSRPHSEQTPAPSNNATPMASRTALERTLKNSSSDLRLRREGVATNGVLPTPAAMNGSTMSLTASTESDHASAASGSNLKSVYAPPSRLSQQFFSPTPPLSPARAASTPNASSRSNAAIQNGTPPTARPPMRTIHNSKVSFANDSSSPRASGHDWSSSISSTQSSYHLAPLQERERTPSLISTNSQVASSYSRSSMMAIPIVPGEDQRAIDATDVEPIDIPLGSSPSVRPELPPNVRRMSEQTLQEARRKIIGTLLTSTDDLHAQHGMTPNGRLSSSLEEARGFALSASLAALEGSGIGGPTTLSLRSDSPRLRPISRAARTQSIELQHDSFIEEDEVGSRSPARAPGELPPRPRIRRSSVTGKIYVPKRAPSPGVGMQSTLSSSSIPIPIDPNLAAEAYGTRRALTKQERRRSEDFPLRPMSISNANRVMNMRNNHSMVNLPSTTRRTSTLSFTSRDSAVYPSLQILEFSMAGQPAMRYQLGNRIGTGQFGAVYRSLNLTNGQMVAIKRIRVAGMQQKEIDDVMREVELLARLSHPGIVKYEGMSCDNEFLNIVLEFVENGSLQHTLKAFGNFNERLVASYVAKILEGLIYLHSQGVVHCDLKAANILSTKNGNIKLSDFGVSLNMRAVETFAERASIGKAESSEVAGTPNWMAPEIIKLAGASPASDIWSLGCTIIELLTGKPPYHNVGNSMTVLFRIVEDPMPPLPPTSPELEDFLKLCFIKEPGDRPSATLLFEHEWVRAARGDIDLSPQDSLPFLRRVSQDQRTDSQRIFANPIDIPKVSDSVRIKEANGIFPTRSASTSLVDLSTTPKENDVQKYAQMSMVSLHSQASQSRECLQSSSARAHGLVKTTFAKAITCHVCLENVKKSAYLCQNCGLITHAKCAARASPRCDVREQLALLAHQQEFAAAVTTPPESRATSPYLADTSPTTSNGLSGFPGRFFGRGNRSKSSLLAPSTTSLVEPDRRARWSTGAGSNHSRSHLDAVPTPASNGHETISSVRSRLSEGSEECVRDPRGASTTLLRIDEDGPSHEKESAGPPPVMRHAPIEGGKPVRKPSMRLRMKREKRDKNGVMDDDDVAPKDCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUD5</accession>
    <name>K1VUD5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUD5"/>
    <dbReference type="FunCoup" id="K1VUD5">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUD5"/>
    <dbReference type="ESTHER" id="trias-j6f7u1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="K1VUD5"/>
    <dbReference type="OMA" id="IIQYWSS"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005137291" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="91"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="612" mass="67335" checksum="7C142F5A4D2D136A" modified="2012-11-28" version="1">MRYLGAILLLSAVVSAGLITDLIDDLRDTFGPIAQEVVRGALFAGGGLLSVLWRQVSNVFADLLNLAIRINAFANPLGDVDAYITPASAAGRRIRITGHHFPDFDSFLGIPYANPLTGRKRFDHPTAFNYTEDVQAFTHAKACLQTLPLLDGVTGQSEDCLYLNVVTPTNSVGTDAKHPVMIWLFGGGFFGGAGSYYSTLAPLMVKKSQELGQPVIHVAMNYRLGIHGFGMGREMASEKLANNAIRDQRLAIDWVRENIANFGGDPKKLTLYGESAGAISTSIHLLNPANKDVFKGAIMQSGHASTIPVPKTEDYQRPYDDFVQLAGCADREDTLDCLRDLSEDEILSVTAQHSRLKQYELGVVSVTWRPTIDGDIIPDSPFRLQAEGKFANIPMITGTNKDEGTLFVNWLAHSEEDNKRLINNILPSPISEDLFAKLFSVYTNDPAIGSPYGTGRNTFLLSPYYKQAAAIATDALFVSKARYYLQQANAHGNPNVWTYAFEAATPIIPPFLGCMHATELLFTYGIVSKWLPVGWTSKSERVSQAMMAYWIAFAHNQNPNTNGQPNWPAHSGPNDRQAQLFSDKGVYPIPNTYRDNMMELFQDPALYGAFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVE0</accession>
    <name>K1VVE0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVE0"/>
    <dbReference type="HOGENOM" id="CLU_329050_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVE0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="914" mass="100484" checksum="53A2C4CFDD5462F7" modified="2012-11-28" version="1">MNLPSPHIARFQRPTVLDSWSPVPVPVKPVTSGNHDNDSCCNSMLLNRWRELGQERNGESSTDTSSSRVTPKAPTFFPVVGYDSDMDIIDSNSDEVPSENPRLSVNKSNGHISIVPGSTSTLSRRPIENGDGVSSDRPHASVTFDQPPQNVLPSPVVTEQGEEADDELPLVFLGLTFGIIPSQWYPKSLSKWHSGALGGRFITPPTESVPDLVLLPLSDERSDLATPVEADVPEHWQCPIAVTSWITQCVMAGKLFELDNPEVPILGLDPLTVRVLERNANSNANLLQGLSAQIARMGESMASQSAAVNAFADGQGALHSQMRQMAAAINTLTEQLHRSHQATTLRIDHLSGLIQHRGRQSQARDFHESSSKIYAAVTDEARRASHSYRREAFVPSASDRVGAAQRPSLHFSSPMAVPQSFVSPVNGVGVRTSTLTSRAGPLPSPPDHDTVVSLPDTPSNGHHPPSSQRKDLVQPSANGANHMSVSCSSRSGDESSSRDTGRSERATAAYLNVAGVAASNPPAANTRDSSEAATVSQLGPLATISPSELQSLLRNVFSEAPQKDHEVFWRRARSIYIEHLGQRAPPRVSITHVSQAQAVLPNRYLYDKIIFVSTVPGEDALAILFDMQEKEVVIYDTIDRYRNNLFTFGKEKTLRSQRCRVLVAQTEREDSFPLVCLATKIFASRDRKSFRDLFPPHVVVAKKNIKNPIPPRRQAKADYYWRLVRPRVVQHLVKELSAVLLTRYRHEETYWVNVPKCSEWVEGLTRFEDSEEAKELPDGRFKVEDGSRPLSRDKKEGGPSAMPSDSTPQNGRVEEPATSESQSCVRRAADEPEQPERHGRDAPARSGHPESAPPSEDNQAREIDSDRQQQKRPAEVEPVEDPATKKQRTVGSAQGMPSEQGAQLHASHSLSDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVS1</accession>
    <name>K1VVS1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVS1"/>
    <dbReference type="HOGENOM" id="CLU_877692_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVS1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="35514" checksum="63459247FB5C163F" modified="2012-11-28" version="1">MAPASSSPDGGAVPMKKRWTKADKAAYRAKRDAPALRITASDFPAELLRVPRQDWSTVPGYQRRPHAYPNAPKLHVEILQAARRASVAWAAGRWREIDDEGFALVVLDKVMQLNEYMRTRTSSETSPTGKATTPDLPFAFVTYFENWKRRLAMLTDWMYDKHGASVRANAQAIIAAAPPATIPTLEFVQELVLHFCEAFHDPTDSVVAGRCWTTLQGVLSVKPLGKWYKPYCKSRAKPQRQPQPQPGSRVLVQHVQDMQDTPHRPRHKRKIAGRVHRVGDLSPLASHLAELARRSLESKSRSVMAPAQHVQGAQDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVS2</accession>
    <name>K1VVS2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVS2"/>
    <dbReference type="FunCoup" id="K1VVS2">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVS2"/>
    <dbReference type="eggNOG" id="KOG2188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008720_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVS2"/>
    <dbReference type="OMA" id="CNSYGSH"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="748" mass="82413" checksum="88E3679D43DBEDF8" modified="2012-11-28" version="1">MPKEQIRKRGKRKPKTEQEAPVPAPTAEFDAPPAPAAEPESIGGIHPSRLAILKRTGGASQQAVTTQTEKQTAELDHRPDEEHPEEGAANWTRVYDPEFPFGVLDPDVKAYFRNLEDQIKDWEGAGAAGEEREDVPEQRAAGIARTRAAGRHGPRGRHSFGEKWETLLTHRFGSHVVQTWMTLAASTLDREKKQEKNPEEGVLPTMAELITSLTTTLIPSFPSLLTNTHASPPLRLLLLVLTPNRALPSLDASEGDGGLVRSKRSGKFRKGQGVQGKSILGDEEQKPTDRQVPESVAALRKKVRDEVMQRISPVEWHGMGVNKVGSAAVQLFLEAEAEDGDSEKEGSLLDIITEGLASNPKDREQKPYLYSLLVSPTGTRLFEAVLSVAPKKIFKALWKTYFRTKLGKFASHPYANFVVAKGVSRLSADGLSEAIAEVQSVGGGKALIKTARTSVLVAFAERATALGKGGDEVMGLVKSATELPEGNNDLVPALMALKTVPTYEAIKNGEDVPEDGDDAEREKDEDAEAAFEAAQRRSAWENRRNAKPRGALDPNMQGCLLLQALVDMPDSTPVLESLFAQPVDALLAYASSPIASRLLDRVLLSANVPPKYKRKLPLAFVGHYLELASDRLGSRVADTIWATADGFLREKIARSLIPSATQLAADAYGRFMAKKLELHLLQRRPDEWREKQLGLKHHFAHQKEARQAADQQEEEQPEEEEPKKKEKKRKGDEIDEVFGKLEKKRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVZ8</accession>
    <name>K1VVZ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVZ8"/>
    <dbReference type="HOGENOM" id="CLU_575132_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVZ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="475" mass="52662" checksum="3C253312CF001C48" modified="2012-11-28" version="1">MRKPDTSPVAAGVTHALRGGYEYDGDGDAVINHYGPARHARHDIEFHTDKKSDARASDQMTTHRSGIAGAGRHFNSTHSTMTEIDSMATAANGDANTKKRKLDTTETQGGEAQNAAGISSNAATSNGNSSSSEAPETEIKRLEGALRKADESIRQMQASREAIAGRLNELGRNVVIKPWTQEHLKTVVEHHLDEFQAEYALCDGVESLPDDAKEDAIRILKMRRAIYTGYQSDGTGYRDADGSWIDFEPTEEDLRSFRWEDADTLWTHQLRRHVLTEEGSIFLGISTSPIHSQLSTQSMTDDQVTKKRKVDVIDVLDSDVEEVQASTSSGSTGSATPNEGSETREDEVKRLRAALKKADDTIATMEKSRRTIAARLQALGEVVLLEPRTAEWLREKIAELEDDFYSNVSEIGCDEDATEEERFDSTYIQRLKDALEGGFPCDKNGYINAEGRYIAFAPTDEELEDFRWSDVGFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWC1</accession>
    <name>K1VWC1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWC1"/>
    <dbReference type="HOGENOM" id="CLU_746365_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWC1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="371" mass="39366" checksum="B6729FBBCBD18D74" modified="2012-11-28" version="1">MRSRSSCPTAAVGVEQSEPSPAPPSAASNSACPKPTADLEGTIDVQGESSECNTLNIFWRDISIPSSLYIISAGSEYQKAWRWVLDGKSGKLEWDLALPVGNRFLVTVAGRQYAGFEGPRTVMASNNQSCLSTRAKEISHQRTAQSEPRSGLSQGAVIGTAIGAATLVLMAAAVAWLLIRKRRALAVRPGEINLHDEWQSASHEHHHVLPFLHKMKTVGNAATSAVPPHHSPAARAPEPQQEIDADAPMRINGPAPPSYNHVLWVTQPPDAETTRTTRNSALMEAKSAILTATAMSISGSSTASQPREDREERGGRGGGGGDGRESSCTALINQGDSRPPADVPGSTSPSLETLPDAHAQPPTRPLPSRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWH0</accession>
    <name>K1VWH0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_01805</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWH0"/>
    <dbReference type="FunCoup" id="K1VWH0">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWH0"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="InParanoid" id="K1VWH0"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="96"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKD03792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="314" mass="34508" checksum="8A466D486F5F81F0" modified="2012-11-28" version="1">MLSSAFPRIATRASRAQFGKARFASSMPQPQAPFWASKTALAGATAVTVGTTAWYMHLYGNPFLTEASANTAAEVGLHPAEYPWPNKGWLDTFDHASIRRGYQVYREVCAACHSLDRIAWRNLVGTSYTADEAKAMAAEFEYKDGPNDEGEYFDRPGKLADYMPAPYPNEEAARAANNGGLPPDLSLIVKARHGGADYIYSLLTGYVEPPAGVTVAEGMNYNPYFPGGMIAMARTLFDGLVEYDDGTPATTSQMAKDVTQFLNWAAEPEHDERKKMGLQAVIVLSSLTLLSLVVKRQKWASLKSRKIFYNPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXB4</accession>
    <name>K1VXB4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXB4"/>
    <dbReference type="FunCoup" id="K1VXB4">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXB4"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009330_0_1_1"/>
    <dbReference type="InParanoid" id="K1VXB4"/>
    <dbReference type="OMA" id="WIQDRAN"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="100"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="271"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="386"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="636" mass="68676" checksum="A445F3389BE68A37" modified="2012-11-28" version="1">MPSPHGTTWGNHRHPGTHPPSLVGPNRARPFSQQTRWAVHVHHTPACLALSSSHAAAFNHTPIPLPFLLSHPPLLSIALSIDPVEAMSVVEVKTTPFQGQKPGTSGLRKKVKVFQQPNYTENFVQATLTAMPGGSEGSTLVVGGDGRYYSPEVVQIILRLAAGNGVKHVIVGQNGILSTPAVSALIRSSKADGGILLTASHNPGGPDNDFGIKFNISNGGPAPEEVTNKIYKITEDISSYKQVELPNLDLSKLGEYTHGPLKVTIVDSVENYVNLLKEIFDFDMIKKYLHESNPKPSVLFDALNGVTGPYGKAIFVKELGLPESSVQNCTPLPDFGGLHPDPNLTYAHTLVEAVEKNNILFGAASDGDGDRNMIYGKGAFVTPSDSVAIIADWAEKAIPYFKNGVKGLARSMPTSGAIDLVAKAQGVECFEVPTGWKFFGNLMDAGRLSICGEESFGTGSDHIPWLSILAKASEEKPGTTINDILLAHYKKYGRSFFSRYDYEEVESEGAEAMMAHLRELFDSPDFVGKTLKATSSDTSFTVESAADFAYTDPIDGSVSTKQGLYIKFTDGSRIIFRLSGTGSSGATVRLYVEKYSKNADEFAEDAQVGLKPLIEVALDLSKLKEYTKREKPSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXG1</accession>
    <name>K1VXG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXG1"/>
    <dbReference type="HOGENOM" id="CLU_083702_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXG1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30604" checksum="75232B25A45496AB" modified="2012-11-28" version="1">MSPSLDPLWFPHILADILHNTDWQTLLSSRLVSTSMLRLVDPMLCGPTLHLQNNTAGTIEAISWGGDLGGDYLSARRVPYFYRNGSKDSRAAAIRKVRDLKLHTDAATEHVNLLLQLLPPHAKIWIEHDKEVFPDRSTATLNTTISLPPCRSLSVAVGSACKCQGAAFNHVAPSVTFYPYDWHYEEEETSGTRSQCALVDGVLNRGVYELHVGADEGYLPKLFKDVNLQVNPELRVVLLGCEDYRVDDLVKTRSATAKCFNIPESQVTIRGVDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXS3</accession>
    <name>K1VXS3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXS3"/>
    <dbReference type="FunCoup" id="K1VXS3">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636448_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXS3"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47599" checksum="A285599040705447" modified="2012-11-28" version="1">MEQVAGAAGSNPLNHEELSVIYCAADSEENAEDGAEATDDGEVELGRKSPISRQPQPLSLSDYLRRVERAPGYRLVPSAMHDRAQSGGKSPCGGWAVEQEASPSFLGIPGSDEHGGHSSCKRYLEILGSDQQPVVVLSTMGYASCSLSRTSPTCALSRVSQLPLPPETQLTFRSPQIWENYMLKSGEGLSLGFILLWMAGDVTNLVGGLMAGLLPTMIILALYLTKQYTVCDLILLFQMYYYRALARRREKALAERQPLLEVEAPKQLKPLLPAYVMYPLLIAFVAMFGILAWVYEADETRNPKIPEKGPEGPGGVELEWRSQLLGYISAILYFASRVPQISHNYKTRCEGLSLAMFFFSISGNVTYIASILFKSLEWKYLVTNASWIAGSVVTIFLDFIILGQFGYFSWQDKQAARAAVFIDEELDAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYF2</accession>
    <name>K1VYF2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit (RpnI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYF2"/>
    <dbReference type="FunCoup" id="K1VYF2">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYF2"/>
    <dbReference type="eggNOG" id="KOG2908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYF2"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="203"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="45931" checksum="E6D4F6B7A6A8B990" modified="2012-11-28" version="1">MSSSMDVDPSSSGSNPLLFLEKQEAAASPQLKPYWTKIRTAYEKKLWHNLTVALIEFVSQPGSGPFQIELFENRFITTIENKINALKLVEIARRVGREYSEPDATLKFLESVHSRLQSPYPVEATAESPAVPAPPRPAPEAYALSLSSIAYAQLLLGDLEGCKKSLTECEKLLSEQDTVEPVVNAGYYGVAGDYHKVKADYGPYYKNALLYLACVDADRELSAEDKRQRAHDLCIAALLGENIYNFGELLQHPILQTLTGTEWAWIKDLIGAFNAGAIGRFDSLANQFASEPILAESMAFLRQKICLMALIEAAFSRPRDGATRLMTFEQIAEATRLPVNEVEHLIMKALSLGLIRGSLDQVASTVDITWIQPRVLEGAQLDTLAEQFGHWTDGVGQTANGVQGLESGAIQNLIQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYH4</accession>
    <name>K1VYH4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYH4"/>
    <dbReference type="FunCoup" id="K1VYH4">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYH4"/>
    <dbReference type="eggNOG" id="KOG3117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031901_3_0_1"/>
    <dbReference type="InParanoid" id="K1VYH4"/>
    <dbReference type="OMA" id="RHTKSER"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="376" mass="40384" checksum="184B86524D4CB28C" modified="2012-11-28" version="1">MSHSNESTPEPPSSEEILKLLGTLQTAVDATESSAAPLLKKAKKADPSLDFEKGISLLLVRPQLLLASLQHLVQLVGLRLTCAKSDTPNAGASAALSTPFNAGTIRERTGEVEAELAGELALCHDVMDKVRSMEGKLEYQVKKAAEVAEDDMLSFRPNAAAMLASARSEAAEAAKPRKSRKESDDESEADGGVYKPPRVAAMPYNEEGEKRVRERRAPALLSEFAQSLAGAPAVQTTSGLSTRPVQAGAHTNSASARRAAELQRIAEFEEENMTRLVTSKREAKRRREDEEALALGFGVGGARNRRRNGLEAELEGVLGDGGSSAWDGAGDKFGKREGITKRAKTAGGRERNGKAKKSRFEKDVKKKRKAIGLPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ95</accession>
    <name>K1VZ95_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ95"/>
    <dbReference type="FunCoup" id="K1VZ95">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZ95"/>
    <dbReference type="eggNOG" id="KOG1531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="InParanoid" id="K1VZ95"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="301" mass="32562" checksum="3B6243147422A9AB" modified="2012-11-28" version="1">MFARSVRPALTAARTANQQQKAGMATLKEIDQRLKSVRNIEKITKSMKVVASTKLTRAEKAMREAKKYGGASNEVYEQTKEGDDAAAAAPAGEAVEKKPIYLVMSSDGGLCGGIHSSLSRYVRKIAAQDPSIQVAIVGDKPKAQLTRMINNDNIRISFSGVGKDVPTFGEAVAIADELMKHGGDFNEVRIVSNHYISALSYEAQTVTVKSAEELRQAAGFQRYEMEEDVSKDLAEFSLANAIYALLVEGHAAEISARRTAMENASNNANDMMGSLQLQFNRGRQAVITTELIDIITGASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZC4</accession>
    <name>K1VZC4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_00788</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000186">
        <property type="protein sequence ID" value="EKD04927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZC4"/>
    <dbReference type="FunCoup" id="K1VZC4">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZC4"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_4_1_1"/>
    <dbReference type="InParanoid" id="K1VZC4"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000501">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.172, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="13">
        <location>
            <begin position="109"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD04927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="454" mass="51274" checksum="3DD02AD77595122D" modified="2012-11-28" version="1">MTSQDVRSILNLPQAGPSSAPAPKKLAKVARKPDGISRELYALIGDNAPSLAEVQASTAAVRYRDRPKLKGKKVKWSVSLYPYGEQGAPRLGHWVRVTDDEPHARVDYFGAFNLHGPSVMEYSQYEYDQHLVDPNWSADETRYLFDLLRQYDLRFVVAGDRYEYRGARGQDPVKKRSIEVGEQSLISLTRQEMKDRYYTICRRLVRTRTASDPQVQQQQIAQYSFDKAAEIAEEEALYLEVKRMEQNERRYRADRDDLMRSIIGLDSGLVSLDQANREGVPGLDPKSKKKRRPDEETPSRPASPGPPAKKPRDQAAWDAQQCIYRLPPPTVAANSSHLASKHPVHQPVHLRSTKMPMPKANSAIRITELLGEMGLSTHRLVMPTRTNLEAYDGVLGAAASLIDMKRQVDRVEQEIRTLKAQKEGFIPPVEQSRKRSESVLSTDTSGTGTRRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZH3</accession>
    <name>K1VZH3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000177">
        <property type="protein sequence ID" value="EKD04977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZH3"/>
    <dbReference type="HOGENOM" id="CLU_662553_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZH3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="366" mass="40215" checksum="ACF7C23839562370" modified="2012-11-28" version="1">MAQAHRALHTGRLLIEVEGSFIDRRSLSPEYEADYPHYPASWAPKTPAVVMRSGRGALPFRSEEEWTWACARSSAVEIDSAALAASSCVAPHATRGFAVREFDNPDEFGLEARKASSVFPSRPVPSTPDSVGMQASLLRALGHVPRSAVVTIDHSGRNGAQGTPAWLPPVDSLVFLLNPRCNCLLFEGGAGPNGLLPPTHSAKHITLRVPPERKYSDSEGTTGSGNESSGVDSDESEDMRGSLCESWGDSDSDSDFKTCQLTCTLVRLSLERLTFSVDLYIEDLRLIKYDYVLTDLMCFRGSAKALRTFDIELRQRSVPDHPAPDAERKQELAERMLRTECAAFFAFDAGMVNISYSDEAGLRRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZJ9</accession>
    <name>K1VZJ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_00696</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD04997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZJ9"/>
    <dbReference type="STRING" id="1220162.K1VZJ9"/>
    <dbReference type="eggNOG" id="KOG4686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030987_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZJ9"/>
    <dbReference type="OMA" id="TWTLWGG"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="518"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKD04997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="612" mass="67546" checksum="C2DF339C6DDAA647" modified="2012-11-28" version="1">MNGVVLPLAGDPEDSDALCDDASFDRAQIPQRYRICAFLMIILFSTGSSYAENVITPLKTRILKELKITNAQFGAVASASSLVNSILPIIGGIGMDYWGATYAAILSSVFILIGAVVSGCSAQTNNYGLLVGGQIVMGLGSTIIESTQNKLYAHWFSGSTLAFVYGIDIAWNRIVSIVCRATAVPLSEINGFWGWALWIPAILCALNLAICILYWTYERSLPREYRPVLGKDARVKEGALKKRISPKFFWILCGTQMFQNSAISVYTSNLSDMQVKTRRTKTLAAGYNSSLQGVIPIVLTPLAGLFFDRVGWRMVFVSWTAMLYIIVFALIGLTKVHPLGPILLSSFALSTNALTFTASIPVLVGTDRLIGTAFGVWKSFQNTNTLILEVAAGAIQDRTPGQAYDNVIYILIGIKSIEMCLGPVYDFLDGRWLGHSLRAPEKRRLEIYRNAVINHLDYKGWRINKITMVIVATQLTCMIITGWAYDGLEAEATGSTADEWCRKASVSVKNTRRVSADHSVHFYTAPPPETETNLVHPEVSLQAFTKVYQLSPGESRRVEVEMDKHAISHWDEYADTWKAEVGAWTAKIGIDAQMMVAAAKFQVDHAMEWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZM4</accession>
    <name>K1VZM4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000295">
        <property type="protein sequence ID" value="EKD02243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZM4"/>
    <dbReference type="HOGENOM" id="CLU_855780_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZM4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="37554" checksum="2D8F688C5A053E87" modified="2012-11-28" version="1">MTTIDIAYFPHIFDAILESADLEALLALRLTCRDIYERISDEWSYVQWNVGEEHRKHLLKEPDVAYNKRGVEVPCNSPCLRLAQAVDLIDENYVPPQDDIPSFLRPEIVRCFGIWPSTVLARAKTLIFYEAWEVCQLNHTLSKPVHDRINMIYHLHFPPEDGYYSRYFDGLANCHHSTDVYILLTGVDPSPGCEVIETLFESMVCSLADEVKAKETRTNFYLVDVPSWFDGSYTSCLEDDLRRLDHTLTSHVIFETYLFSGWDTQGEDGCFYSTTQYLAEERAAACERLSQVRCITRSEMRQQVGDKAYDLTFAPRDLRALRAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZZ4</accession>
    <name>K1VZZ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZZ4"/>
    <dbReference type="HOGENOM" id="CLU_903693_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZZ4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="308" mass="34635" checksum="1FD618F44C5093E3" modified="2012-11-28" version="1">MVDLQALGSSFPHIVDSIILFSDDKTQRTLRLTSHFLRQHVDLTLHRALQGSIWYIENASGVFVRGLDIDSIRRVVSRWDEHPHFPGLKAAKAVFFCDTPADTAEQVASQVSPDVVPYVCHFSSPAHYPLSSASRAVLEVSLLDCHCDDDRPEYDYGLNTPDVLVTLWWQSAGWYDPVTGVLTPGLPNGVFYPPGKEPRITFPTSCRLLKKVLHPNLKTLRLLCPLVLLRPETPSFIFPKPSSDLTLSDDFKMTIEINSLEDAESEEAREAQKAFATYLGVTEAQVEIEREGKQARPSWWPPVYSVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1W154</accession>
    <name>K1W154_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W154"/>
    <dbReference type="STRING" id="1220162.K1W154"/>
    <dbReference type="eggNOG" id="KOG0753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="K1W154"/>
    <dbReference type="OMA" id="HARRYCS"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="216"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD05532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="307" mass="32917" checksum="3C16F3B144ABE14E" modified="2012-11-28" version="1">MSTTASPVPALQVKKDLHPAQELGLKCLLAGISNSVSASITNPADLVKVRQQLYIKQGSGLSPGFFSTLVNMIRSEGFLSIYNGVSASILREMSYSGIRFGAYDLFKSGILSLSPGLDPHSVFVKLGAGMGSGMLGSAIANPADVLKVRLQAIGGSQLGLIGQAKAVYAEHGIPGFYRAVGPTIIRAGILTASQLGSYDVAKHFVRTHHSHILPEGKFTTHLACAAFAGFACSVTSAPIDTIKVRMMNDKVDQYKGALDCCWKLLRNEGPLALYKGFFGCWIRLWPHTVISVTLFERLRAYMGLNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2U3</accession>
    <name>K1W2U3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_02496</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000262">
        <property type="protein sequence ID" value="EKD03213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2U3"/>
    <dbReference type="FunCoup" id="K1W2U3">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W2U3"/>
    <dbReference type="eggNOG" id="KOG0327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="K1W2U3"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD03213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="398" mass="45020" checksum="38C9E9C9EDB3664E" modified="2012-11-28" version="1">MLTFNRTNLELAGEQIESNWDKVTDNFDDMELKPELLRGVYAYGFERPSAIQQRAIMPIITGRDVIAQAQSGTGKTATFSISILQRIDTTVKKTQALILAPTRELAQQIQKVVIALGDYLNIDCHACVGGTAIREDIAKLNEGPHVVVGTPGRVFDMINRGALRADSVKMFCLDEADEMLSTGFKDAIYDIFQLLPAETQVVLLSATMPQDVLEVTKKFMRDPIRILVKRDELTLEGIRQFFVAVEKEEWKLDTLCDLYETVTITQAVIFCSTRRKVDWLTQKLHEREFTVSAMHGDMDQNQREVIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPASKENYIHRIGRGGRFGRKGVAINFVTTEDVKMMREIETFYNTQIDEMPLNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2U8</accession>
    <name>K1W2U8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2U8"/>
    <dbReference type="HOGENOM" id="CLU_2308030_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2U8"/>
    <dbReference type="OrthoDB" id="4505683at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852234" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="9940" checksum="D41E9E026797163C" modified="2012-11-28" version="1">MKTVFALAAIAAAAGVSAQVDASQINGCVKDCVFQTAKNVGCYNEADPTGSVNCICGDKRGDFTGQAAGCISGGCADQLAGAPALLDKLCNEGLKDGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3M1</accession>
    <name>K1W3M1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3M1"/>
    <dbReference type="eggNOG" id="ENOG502SCB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161533_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3M1"/>
    <dbReference type="OMA" id="PSKMDIM"/>
    <dbReference type="OrthoDB" id="10008801at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="127" mass="14035" checksum="5FC88C18DFFB4806" modified="2012-11-28" version="1">MFSVLRSTRLVARPLVQRAPRAVASLHASARVRAAADPFNDPQIIEMRAKIQNHEGTKAAIQKLGELMQAKGVDISKPPSAMQMMKLGMDPEIREAGQNMQEAGVNLTPEVFSKIREQEEGNDNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W493</accession>
    <name>K1W493_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin containing amine oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W493"/>
    <dbReference type="STRING" id="1220162.K1W493"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_10_3_1"/>
    <dbReference type="InParanoid" id="K1W493"/>
    <dbReference type="OMA" id="CWDQDEC"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="463" mass="49288" checksum="98BD0F086B5E1F4D" modified="2012-11-28" version="1">MPQVFDTIIIGAGWAGAVAARDLAHAGRSVLVLEARDRIGGRARTWANGDARIDLGCSWIHGYNEGNPARWIAKDMGVQTTHLPKPTPSAIYGPSGPLETPVAAQLGSALGAAQAAFRTPHPAPGPRESLADALFSSASPLGKVEDKSLAEGFARTLEVPLGLKLERASLRWAGWEGATNFAGSDAAPEGGYEALVGKVFQDAEKHGAVVKTGEPVTGVRDMESGVAVQTDKGSYQARTVLCTIPVAVLRQQLGIFHPPLPERYQDIVRGVNVGVLEKMLLNYDKPWWPRANEVASYIFLPTKAPGGQSLMDVLESSTIITANLAGPALPGATPTLLSYLSDTPARAALSVSPAEVAQTFHAFLKKRLDVPDAPEPRASEITNWLTDPLSLGATTTPTPVSDGERSPMDFKELSRPTWDGKLGFAGEHTEMENRGSVAGAVVSGMREADRVKRYLSKHDAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5A6</accession>
    <name>K1W5A6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5A6"/>
    <dbReference type="STRING" id="1220162.K1W5A6"/>
    <dbReference type="eggNOG" id="ENOG502QVFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275730_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5A6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1157" mass="125222" checksum="475EA98896967792" modified="2012-11-28" version="1">MFSNNRDYIDSIDVEESMGDLYGSRGRHGHMHGSSVSSLGSLASPVKESSSGGPPPLYCTLFLFDDKLLIAKRQSTSVNGRKVTGLEDVSKLVRSGGGVAVKEKDGAKNWKLSYRGTVNILDVIAVDLGDGDFQLFLEKPLMDQSDRWSGRPLRTYTAVNPPTPIGLDPATARSDKLRFIQNLWALQAMARTKVLPSQLKEIPRVLTSHNDVSMDSEHMRVKLYWNLWTRKGWESEHTKAKVAMQVSDENEERSQSDLTCLGPPNLVFRLVAIEGDLVRIAYSGPNTMLQTTVCHLEDINMRLVSIISDQGCLKFDTSNIVQPHLLSTPGKRASRLNFLTGTASSRSNFGGSSYGSSINSHISTNEAKSISSAGRSPLSPRSPRSPTTPQRKASGAIDIPPPPVREEEEEAPLGTVFQRAPQPHSPGQIPSPGSRISRVQMMREQIELRQHNSLESPSTPPKDLPIRNGRSPVRSGIATFAQSIAGNESRVLSPSPSKPKRMDEPLVFNTAASNLKRTDTLLSRTNTMSPRGPRRNPSVRKKAEDQHPPSRGTRSRSASPTKIPSPTRVLSPGPTATIPSPSRVLSPGPMSSIPSPSRVRSPPPTSIPSPSRVLSPGPPSRALSPSLPRPPSRTMSAGLMNAGLMSPQRARSPGLASPARSPARSVSPAEGVRTPTKTGYIPPLPPPTPTVEEEVLLDEEPMVASPVMSPMRAQSPAPPVSRPMSPHGRALPQPPGPAGNAMSFNLNSIPLGTSPMRLPMLGPDGVLVPPQGPPSALARSPVPSAVCTTGHSLNVPSPQPSRQPSPQTSPKASPRQPPRQVTDENSPSGYADDSPVLSTKRQHKAEYSSPRKRVPSDTMRVASNGSEKYGSVGLGKGPRPRNTTPKGRKTSGTLTPTRRVSAMSNVSVVGAGTRSVSAKSDATMQTTDIDDVVMSDHADLPTAADSARQRIADARKLARRLRQDTGHVRKHTAMRGAGVLRSPRVRGLADGNDELDDVTRALAHSSDKLESTLVSALADAERVRMLVRSYDAHATRTASLESAIEEARERTSQLEAQIQQGKEAHELLRSQLAAKELEVEEMYNAFNAELDGMYNDATLELLPQTEAMRADLQQTKTRRNALEVENSKLRLEREEMELRIRQMAEVLARNGLTLGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W617</accession>
    <name>K1W617_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein HET-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W617"/>
    <dbReference type="STRING" id="1220162.K1W617"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010063_0_1_1"/>
    <dbReference type="InParanoid" id="K1W617"/>
    <dbReference type="OMA" id="AWDDTSM"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852284" evidence="2">
        <location>
            <begin position="25"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="635" mass="69537" checksum="20F01EC6FDF50D0A" modified="2012-11-28" version="1">MARNTLFFIAIAIVALSFAPKAYAFGAGNIPSYSYMEDKAFRHGDIEDVIAKMIKITGGGFLSRGVKFSGLDAHLLWKLAQRLLPAHGYATGEFEVTKERLGTYLPTEHIDNPKGYGEGEDPRKYDPRLRPPVDPRELEIDPQSGMKNYIANAHSNYCELVLISLGYQNVFPHVGRNTQIRSPQGRPVYPLVTGSFGGADFIHSLMGEAGDKLSSDPSTMSPQELYQTLWKILSFRDSVMKKIENTLDKIPLLGALVEKISNSVSVFIMTTLEPYVKPLLGTATTALGDSSQALLDAHKDDQFEVWNNPNSTDPTHSFLSKDHFALILNEPAGQIAKIIVQYSVERIVQCWSDSNINPNQAITDILGCLHHPDFRNPNSQIQTQMFEHMRNWIEQTGRDKNEIINRLGSDNVRNGKNKRIGDNSADTGHVHAAGLPDGGLQAVLAQHNVHVDLASGKMQGFGQGGQHAWRGMDDGAQQSYGGNNSYNQQSQQSYGGNNSYGQQHQPQHQQHQQSYGAPPGPPPQQSYGQSNYGQDQSYGQHGHGHHQQGGYNQPPQQQYGGQQGGWNQPPPQQYGGGGGYGQPPPPPPGQYGGGGYGQPPPPPGQGQWGQQQNQYGGNNQYGQHGHHGPSGAGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7A0</accession>
    <name>K1W7A0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7A0"/>
    <dbReference type="STRING" id="1220162.K1W7A0"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125101_2_0_1"/>
    <dbReference type="InParanoid" id="K1W7A0"/>
    <dbReference type="OMA" id="EHMGSKD"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="115" mass="13043" checksum="BD695BF8CFAEA803" modified="2012-11-28" version="1">MAANSQGIQTLLEAEKEAAKVVQKARQYRVQKLKDARSEAAKEIEQYKAQKEADFKKFESDTSTSQTTIDTDKDEQLKKLDAEVKKNGPDVVEKIVSRVLKVNPELHRNLKKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W817</accession>
    <name>K1W817_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000161">
        <property type="protein sequence ID" value="EKD05013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W817"/>
    <dbReference type="HOGENOM" id="CLU_1240902_0_0_1"/>
    <dbReference type="InParanoid" id="K1W817"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="223" mass="23396" checksum="73A2AE3033FFB15E" modified="2012-11-28" version="1">MAPDATIKAASLASLAAQPPRHDRVAELSGQQALSPKSSPTLSQNSGLEDKIDGGYVHVSEIAPLRSMLENATTVRECQVLVDALLTQLGVPRDSMTVNDQQDRVAEWLANERSVPTGDNVSELQTPNGSPKLKVKSHRSSLSAGSGKRIVSRKSSKGTTVGSLSPEITMKNLPALPIPEASPEPPSASSDPTSTSSTTTTASVTAQQQQQDGPPHTLVETKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8T0</accession>
    <name>K1W8T0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8T0"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256441_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8T0"/>
    <dbReference type="OMA" id="FMASEDD"/>
    <dbReference type="OrthoDB" id="2596920at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852339" evidence="5">
        <location>
            <begin position="18"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="818"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="819"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1369" mass="140333" checksum="51DBCD9716E0E53B" modified="2012-11-28" version="1">MPSRALLMLAMLRVATAADPPPRWGAAVAVVPSPPTLVVQGGKVQSEGQTYNSAPNSADTYMVPLNDSFPANDPPYQKLTPRTQGPAYSWHCLAPLYTEDDKWTLLSFGGDSGWSEPRPGGEDSAWLVNVNPNDGFIDFDHKPAGWAKEPSRRKEHSCAAPAGGGKVYITGGQADDGSADHNETWVFDPDPMEFSQLPSLPNKLYGHSSVLLDNGTLLVLGGVDAESQELRPLNTIQAFDTTAQQPQWNSVNIPGDVPGGRRSASATLINGDNVLLFGGANENRSTVFGDAWVFNPSTLQWDMVMNDENGPGARYDAAVAYVGNGQVTIMGGYGADGPASGDFHVLNVITAGSSAGGGAGGGGAGAGGGEGGASGTAAAVSSFFPGGQGAGGAAGAGPTGQGGAGAAGSTQSGTLPAATQASSFTTGSGGEIATSINTRPKPGETGKPTPHPQANSSSSNAGRNAAIIGSIVGCACLVFLALILFFWCRRRKRDEKYQKEVAQRRLTKEGDAEAWAAHTTPPASPGGRFAGMAALGAGAGAVAATLRKISGGRNPEYQAVATDEPTGGTGIAPKRRSTRYVGQKMRLVGHSEGHDPFSDTYSEDLPFEGTSTGQTSAFGPGIASTAVGMRQRQVSNEHSPILEEDEEIPIGGRWATANLILNDSNSDTTPAPTSPTRMSRASFMASEDDFNLLAPIPRRPLTEGALLAEVPSRGSGVSGASTSGTSMADLANASVEQGNRVPLQSDAPMLWDMANKAPVPGNPSDFTPFSPTMSDLSGSDLVPPAMLLRLGDHSGSESSSVNSKHRMVARAIAEPRGIGSEHGEIDETSFRDSRSSRASAGLDGQYGATSRHTFGSMEPKSPYYFPEEDPDATPVARHTERFGSETGLSDLIPDFGSTPSSLIRLNVPSVLERGGSDSSGTYSASTWGSNVASNVGSSFSGKSGGSTAGTWATAASEVRSDSSEVGGSEVSTASTVGTWTTAPPQAPPELEEELAALRDATPVATPRLSRVDTNPDLACVATPRVVSSATIVAPTGLGMHNVSLGDSPSAAGSSSLQRSSSGSSTMAVVGSQPSARERALNRSLEGIDPPQGLGEFKSPPPSLAPSLPPSPREMQPWPETEFAPTCRPSPSASIFTVPTLADAPDPFQDPPSRRGSAGSGVGGTPGVGPTSAGTAIGAAVPVAVTAGGMASVPLGGTEGVESDVSDAVENLASPVLSPAPSPKPQRTLAGMAGLGGGLIAGRGMGRLRPVREAIDSINRRGAGLPSRFASGGSRDFTPTPPKNKDKDKAGSGSPAAAVVASPAKPEPKSEPKDESKGTDRTASPLLKKQGLSEFHLRPTHRYASPASFRTATESTSHHSHSHSNSSSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9M9</accession>
    <name>K1W9M9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9M9"/>
    <dbReference type="FunCoup" id="K1W9M9">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9M9"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280458_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9M9"/>
    <dbReference type="OMA" id="LKWRARV"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="384"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116110" checksum="7788AD29B0B614BE" modified="2012-11-28" version="1">MTSSLAQRPIKEYDNDPGVDHILADLLSTASVKSESSGSNGAPRSNKVRRGGRPPFPPGPSQLTPRFAKEKRHYSYPQGTDDKAKWQFWPKTMWLGSLTGPEFTRVNQDRRGHGHSLLAFDFERELLVMRTVFQLPQEKLPPAFKPLDAQLRFNDISRRGIHIVEEKRGTLWRVVVTVSLRRPPKFDAPLDGVHYMADGKRLYKRRATLMDFVLCEVAESRAGVLRAIPEGPAANPTFWDTYRWEFLLNNDEYRKFCHCSDRFRTLAQEDPETDLVSLNKREWTRTRRLHSEWTVPDLRSLDFSSRALVEGLIGHGIVRPIDVAELLRALDEFAKALPFRQRLLTNLFAEERVRNVYTVVKPAALRRGEFPVSRHIVMIRTVTVTPTRVLVGPPQPETSNSVTRRYSDKLDAIIRVHFTDEGERLNVQKFTKPADDACPEKGLMARVRRALQYGIEVAGCRYYPVASSGSQQKDHNMWFIDHTVIDRPELSRWMGQVKEQVVAKHAARLGLPFSASRAVALKVTVSDLADVFRNDHCFTDGCGVAGIDVMRQAARSMNNKRKTGEAPSALQFRLGGAKGVLAYWPGMAGNDEILMRPSQTKFESRLKELNVVRIAKYQAAFLNRQFINIMSACGVPDALFEQLFVEATQAIEGLPDRAVLRDLTKDDLVLFQQYTEFPMVQVIDAGFARNPMIQDLARLVEARALQDLKWRARVKLDMGVYLIGVADETGLLKEGEVFVQYQVTENDEPVVVTGAVVVCRAPALHPGDVRTARAVDHPQLRHLKNVVVFSIKGARPLPNILHSHLGPAFLRYNLANCRRLDFAKTELTTELRPEKWPDFMGKTYKSKKVLGVLFRRVQADPKFEPSDIRRSAYDPEHWLWGHPQYHDIYTRLMAVKAGYECDMHYAMRRFSATELEIVSGIVTYHKQRKTSRDITEVSESLKDHYEHITNLCREQARKCLEAFSLPAGYTAMQIVAVHAYFLTYGKQFIQQWEKQGPQMLWGPQAPQAPYDQDLLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9S7</accession>
    <name>K1W9S7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Benzodiazapine receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9S7"/>
    <dbReference type="FunCoup" id="K1W9S7">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9S7"/>
    <dbReference type="eggNOG" id="KOG3797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091805_0_1_1"/>
    <dbReference type="InParanoid" id="K1W9S7"/>
    <dbReference type="OMA" id="WSWLFFG"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20663" checksum="2814D7D0E0452EBE" modified="2012-11-28" version="1">MAPVPEILLNVARNPFLAVGLPIGLGIASGFSVDPQSIWAKSLKQPPGAPPDAAFGPVWTALYGMMGYASYLCSTAIDMGATFETKALAENALGEYYVQLGLNLLWMPTMYGLKNPILALGNIGILAGLVWDMTGKMSKLDTNPNTKYLLVPYALWVSYAAYLNAGIVYLNWNNTTAQTLAKKLHQPEHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9Z1</accession>
    <name>K1W9Z1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Purine nucleotide biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_07225</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9Z1"/>
    <dbReference type="FunCoup" id="K1W9Z1">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9Z1"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_3_1_1"/>
    <dbReference type="InParanoid" id="K1W9Z1"/>
    <dbReference type="OMA" id="IKHNNPC"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="221"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC98488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="829" mass="90168" checksum="F3B7A3EDC036793A" modified="2012-11-28" version="1">MLTQRLPRTVRRITKTDQIVEHIRILLIIRQLCTVPLPSTVTSARMAPPATPNSADFPNPVRASAATLKLLEDLHAKSLEQEAGTDLMTVPKEQFKQAGTSYGVSTIYLALAVLDNTGGEGTVIATEHEPEKAAQARKYWAQCEEDIEKVIDLREGDLLETLKTLPGEVDLLLLDNGADSVEKTSAHVIRLLTANTMSVWAPMAFPTLKLVEPNFRPGSVIILDNSIKSAKPLLSVYDKTNLLPFAKELKALGFRLLGSGGTAKLIRENGIEIDDVSSITNAPEILGGRVKTLHPAVHGGILSRNIDSDLKDLADNKIDQISIVVCNLYPFVLQTQKPDCTIAGAVEEIDIGGVTLLRAAAKNHDRTSIVCSPDDYDAVIKEIKAEGQVSAATRRGLALKAFEQTTAYDGAISDYFRKQYASVDSEPELKAAAGVGYQRLPLRYGANPHQKPAQAFVTEGELPIKILSGSPGYINLLDALNSWALVKELAAGLNLPAAASFKHVSPAGAAVGVPLSDVEAKVFGVDDLKELSPLANAYARARGADRMSSFGDFLALSHKVDVPTAKIISREVSDGVIAPDYEPEALEILKKKKGGKYCVLQMDADYVPADIETRQVYGVSLQQRRNDVTIDKSLFTNLVTKAKDLPESAVTDLIVATLALKYTQSNSVCYALNGAVIGLGAGQQSRIHCTRLAGDKADNWWLRHHPRVLALPFKKGTKRADKSNAIDLFVTGEAFRASPSERAQWESLFEEVPEPLSEQEREEHMAKLKGVACASDAFFPFPDNVHRARRSGVQYIGAPSGSIMDEECVKVADEYGMTYAHTNLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA26</accession>
    <name>K1WA26_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA26"/>
    <dbReference type="HOGENOM" id="CLU_1983131_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA26"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="126" mass="14214" checksum="FF831459F1E05A2B" modified="2012-11-28" version="1">MSVFSMNDFKSLEEAREALITDYDRQRAELRQRSMAIKRELLRKTGQAKALRALRKHTKEVTRRLKKDLKEKLAAADLWAFEDPNYPAAASGSSPAEKEVTEASNDDVEVKSEPQNSGKNTVAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA91</accession>
    <name>K1WA91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000017">
        <property type="protein sequence ID" value="EKD05678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA91"/>
    <dbReference type="HOGENOM" id="CLU_1428926_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA91"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="190" mass="18741" checksum="8D2D1B144E9ED229" modified="2012-11-28" version="1">MLPVPEGDNEIPAVPAMPPHLAAMGRVPSTTDTPSSSSNLPLAAAAAGAGALGAGAAALGLRSADGSGLPTRSSMGMPTSPGAPVTGLPSAGVATSPEVPTSGLPASSSMSYMTRGMRTSAGPPMRRPSPPDITVPKPFATMGIPTSPGAPNARHTSAGPPAGYFQPTDPATPTTPLTPRESDSLLNRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAL5</accession>
    <name>K1WAL5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAL5"/>
    <dbReference type="STRING" id="1220162.K1WAL5"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_3_2_1"/>
    <dbReference type="InParanoid" id="K1WAL5"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="24354" checksum="6205B4F0CDFEF17D" modified="2012-11-28" version="1">MLNVVPLLLGRVLVLHELDKGAALGRQRADDVGTAVLHEARRGGFVGGKFVHDTDAEMALVQKYALEHGADYAVPANHWAKGGEGPVELANAVVEACKDESQFKFLYDTELPLEEKMAIIAREMYGADGVELSPEAKAEVERYTKQGYGNLPICMAKTALSLSDDPSKKGVPTGFTLPIRNVRLSAGASFVYPLVGDMSTMPGLTTRPGFYDIDLDPETGDIVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAT1</accession>
    <name>K1WAT1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl-CoA thioesterase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAT1"/>
    <dbReference type="STRING" id="1220162.K1WAT1"/>
    <dbReference type="eggNOG" id="ENOG502RSBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1586411_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAT1"/>
    <dbReference type="OrthoDB" id="2592105at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="189" mass="20282" checksum="26C8736A33BC1632" modified="2012-11-28" version="1">MSSPKKELIPATDADTEHLRYFLGAMPFAGDTFAPHCKAVAYEPLPPVNARGGRDCEGWTCVYEAVVQDNWLNGGQGLHGAAAAWLLDMFTGTSLHRLGTDNWSPWGPSINFEINFYNPAPAGTVLRCETIIDRAGGAVSTVLCLMSDKKTGRRILTGVHTTQRPKGGAFGKVGAKFNMKAAQTATAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDI7</accession>
    <name>K1WDI7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDI7"/>
    <dbReference type="HOGENOM" id="CLU_1225530_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDI7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="24458" checksum="C543A23AAC0F69B2" modified="2012-11-28" version="1">MSREDIGLRLIKAFKPCGVIEAVKVFLKPLPINDTKGIMACARGDSGLGAVDASEFASDIVLYYNAMERDAVDVYEQSFAGKWLEEEAEAKAAAARLDPATHSLVARLTFADAAAAARARQLCLVPSNKEALEEVRVHCARVNALEFPSWKAAIDAPSDTDLDMPLSKPPNDIKPVSTLSDGRSLSVWDGTAAPTVAPLKSKKWVYFGPADLLLFEDPRKPLLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDT8</accession>
    <name>K1WDT8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDT8"/>
    <dbReference type="HOGENOM" id="CLU_790333_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDT8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="351" mass="38066" checksum="67752E0A4C31AF80" modified="2012-11-28" version="1">MTRSWRGSGSTSQASSRTLAAQLVSAPPRSTPTHAAQRARSLVFLPLRLVSTFSHARARDELPTNILFLDWFLSLTEKRQYMNIDNLYYEHQDRTNNRFRSKRRSRAADAQTPALTADVTSPATLAAPSPSHPYANASNPASPTPNFAPPVFAGPSHPPLFAAPPTTTSSNSHLPGYLRCRNSQGEDEWTGTILACDRSGATTRLSSPSTPTRSGGSRSEGIADACQPTGARTCQRERADGGSVGRLAEIWTHTRLGGGVVFRIDDALALAYKPRYTCPGPVRPTLATLDTSPPSDLRTFKQSLARPIDVFTHRITATVIARLGPLVMNKHHTDMITITTHITTTTTSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEH1</accession>
    <name>K1WEH1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEH1"/>
    <dbReference type="HOGENOM" id="CLU_027594_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEH1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="619" mass="68646" checksum="9F71154B0722EC7E" modified="2012-11-28" version="1">MHLEQGLGTIFPYLSQIIAEARLSSGTCKLSDSYSWPFDLLNSDRALWWVINRLREASTLEGLPAHASSANFPSRSSAVPTHESERASTHFGPFNDIGISLALQSCDMPPVNVARLTVVQRAKWLHYIHRRSGPLPLSDFPSLTHVVATMVEHYDFTDEIAMVVYGVFESCNINIVVHHDRIPSFTGAPSTHLHDVSSVRNGVTLEGINGTTVLFLACLVLQEAKAIQKLLDMEVTGPVILRDMANCGLGWVIQPRDAQDIISNWLERDEIPRDTTAPCPRLSLFLTAWVTRPGGPFDTPMPSGAPTVLYEHALDWCPQNILEPEGARDCSAEDSPEEAHAQVPRQRGLFFGCALGTAIALYLDCLDTQDRVRDCSPARDHRARDWVWDLIRDTFGYLPGSSSTLQALEAADAFLTEKMEQYPPDVLDNIKLLTNQAMERMERMQTRQASSSSSVGAATQKDLYRAMVFSLSGHRLRDVGANVLAWCPVPYLKEVSDRRLWLLGVQPAEPRQPAAPRSRNRGRLLRALDILIIGYLSLAAVIHVPFLIQSLASLRHNAKVVVPNVDVGLATMKTCVYVGTERFAEEGEIVTLLSGGAKDWCKVENIRRMILVSNPILQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFC9</accession>
    <name>K1WFC9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein required for the maturation of the 18S rRNA and 40S ribosome production, Emg1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFC9"/>
    <dbReference type="FunCoup" id="K1WFC9">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WFC9"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFC9"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="339" mass="36630" checksum="10889A42EAE59D1C" modified="2012-11-28" version="1">MSTRNFSQPKRRGSNSMLPPPKTSKMSAEAPVFQPRPKMEEEDPAVAASAASAPNPSVTTGEGGQIHGGAKEIDSDTREKLNAAVAASRVTRPLPGSRRPAAAANMVPQAATTVKTGEEKENRRRLIVVLSQACLEAYKINSSSSKGKDAKYALLNCDDHQGILAKTGRDIADARPDITHQCLLTLLDSPLNKAGLLQVYIHTAKGVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRGVQGSEKLLRVIKNPITDHLPTNTIKLTLSGDAPTVRLSQFLPTLPETHSICVFVGAMARGPDNFADHYVDQKISISDYSLSASVACGKFCCAMEELWDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGF2</accession>
    <name>K1WGF2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000339">
        <property type="protein sequence ID" value="EKD00574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGF2"/>
    <dbReference type="HOGENOM" id="CLU_950576_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGF2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="305" mass="33762" checksum="05114DF4958C5B1A" modified="2012-11-28" version="1">MRDNKGSTPGDKLDIRTTPPSIKRSRDWQQAIAFCAKVAPSAHVPYRMTAPPKYVAAMTVAHVLLPPGSVKRGIFKVKPYFFTSFSYEARDDGKCSSCGALLTETTTCTREELVKAFTTLEADLEALVTAAAGLDALALLPFTGDAVASGPMIRFEPSTRPRILALQARAEEAAQRMRWGIKYFARYLAYLSRKEEDDLHPGFWVAYPGKLDAETVRFPPEPLGWRSIPVLDDYAFRAARIVNASPESPREVTELRMEIVAFAMEMVTGKGYEAGVVWEFLPRHGLSHEDDGPEALMDAPPPYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH07</accession>
    <name>K1WH07_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH07"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577707_0_0_1"/>
    <dbReference type="InParanoid" id="K1WH07"/>
    <dbReference type="OMA" id="SPMIMAN"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="386" mass="42401" checksum="71D9C8AE1D035198" modified="2012-11-28" version="1">MFRFLLPESLSSESRLQLSKKAKLAAERRRERDQEQMHWERMGPRRMGSVSPGPESSPGDSGWSRVRAATSRHRTVRRSIGSLRRLVRRSLWFLEPLKVLIPEKIDGKRDWNLPIVAFMLFLGSWIMGVLQIKFMYAFYAFGWGTAQFGPYLSFIALCRGTVLLGIMPAAMYFVKPWFTAPSVAEPVTVEPATEATPLLRETEGAGAPANTSEATDRAEPQGQPKRSLSLDLTVTRLCLFIEVVGFLVLGLNAGNSAVIFVVASAYLTLGSPGSAACNSLALGFLRNQRDAGALFGALAVLSAIGSALLSPMIMANLFSATVGIYAPAIFLCAAGILTVALLSSFALRIGRHPDEESARGRETQRGKSRSRSRRRHRAERERARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIW8</accession>
    <name>K1WIW8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000318">
        <property type="protein sequence ID" value="EKD01369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIW8"/>
    <dbReference type="HOGENOM" id="CLU_1090660_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIW8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="255" mass="21618" checksum="9D21414A325550D1" modified="2012-11-28" version="1">MGTGTSGGSVSGGSSSSGGGSSGGSISGGSSTSGGSSSGGSSSGGSSSGGSSSGGGSISGGSSSGGSGSIGGSSGGGSGSATVSGGSSTSSGSSSGGGLLGGLGGLGNIISGGGSSGGSVSGGSSTSGGGSSGGSVSGGSSTSGGSSSGGSTPAAALALALAPPPSRADLPAPPRARLVALEAARLAAAAPFLAAAALLVAPAPPAAAPLAAAAPRAAAEAALSPGALARRAATRATTRTATASKRSSVLALSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKB3</accession>
    <name>K1WKB3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKB3"/>
    <dbReference type="STRING" id="1220162.K1WKB3"/>
    <dbReference type="eggNOG" id="ENOG502SBAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_662547_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKB3"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="415" mass="42731" checksum="D8430F4A7DCA1484" modified="2012-11-28" version="1">MERELGRGRGHAEHARRSRDSTLPSARPEPAEKGDKQPAPEWGWPAADQSVRGGLGRGGRHWRTQAPRLDGRRGGKARSRGDGEADRGAVLRLSELVIAPTRQHTSIGKFLRAVEKMLTVTTAYAPPSYVYVPPAQFDLGAGPTSPSSVISEMDADSTVPPASMTPMFSPIPFLAGDELGEPMLDQEGNPGDGLMSPLMLSGESNGVFAPQQPQNGSGGAGASGRSPTPEPEEEGGAGGAEAGAAGAAAAGGDGAGAGNSETSETSETTNPGNEPYLGRVDELDAGPLAHTNGADEGDLATGRGEAGNMTPHGMHSRPEPISSTTVIKDDEREIAPLPARAEGVDGGDAVMADAELKEEDKAEKEENPGDKEEAVEAKPADPAETSETKDGSETVAEKAEEKPADAAAEAAEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM71</accession>
    <name>K1WM71_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM71"/>
    <dbReference type="FunCoup" id="K1WM71">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WM71"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_1_2_1"/>
    <dbReference type="InParanoid" id="K1WM71"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="90"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="380"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="464" mass="51453" checksum="9C789796C849F4F0" modified="2012-11-28" version="1">MLPRRPNPLHPFLYNFARVSPRPHALPLVNTAAAATPVTALRVVRQPLVAQSLYFSTSPAAYAKRNKKMPPKKKVVEDKKVILGRPGNNLKCGIVGLPNVGKSSFFNTLSKTDLGKAANFPYATIDPEEARIPVPDDRFTWLCDLYKPASKVPAFLTCIDIAGLTKGASTGEGLGNAFLSHVRAVDGIFQVVRAFDDAEVIHVEGDVDPIRDMEIISNELRLKDIEWVEKEIEKLQKQVRSCGNVSLADKAKKEELATVEKILKTLKEDNKDVRKGQWSNKEVEIINGLTLLTAKPITYLVNLSERDFVRRKNKWLPKIKAWIDENNPGDALIPFSVALEERLVGLSEEEAEAEGEQLGLGKKNPSILGKITTAGYQVLDLIRYFTCGPDEVRAWTVRKGIKAPQAAGVIHSDFENKFVCGEIMAFEDLKQYGSEAATKAAGKLRQQGKPYEIVDGDICYWKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNC5</accession>
    <name>K1WNC5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNC5"/>
    <dbReference type="STRING" id="1220162.K1WNC5"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799710_0_0_1"/>
    <dbReference type="InParanoid" id="K1WNC5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="347" mass="37132" checksum="127F65CFF89D2DBB" modified="2012-11-28" version="1">MLSVASSRTTPSATDQTPMPSAAAVKRVILSTRTHAHAAALDSNSRSVGMWAIGGDGNACYSKEAGQQPAPWSGWRLAMTSGWPISSEKAGQQPQPAVVDFGKRPRPSPDPVTFSCRGYKAGALRPPQSSQPTSRRRVAHIFNICLPRLATHATHYTSSMIDLKGKRALVTGGSRGLGAEISKQLADRGCKVAVNYAASKDRAEETVKSLKGDGHVLVQGDVFSRAGVEAVAKEAKEKLGGVDIVISNAGWTKIAPWSDIPVSKAGSIHLVRGLAKSLGPNIRVNAVAPGLILTEWADRFPEEVKENWKEATALKHVPYTEDIAQTYSEYGDWLRGQSDEEQGSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQV2</accession>
    <name>K1WQV2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000249">
        <property type="protein sequence ID" value="EKD03429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQV2"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005017_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQV2"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="199"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1417" mass="153241" checksum="E27CF594BA20C7F1" modified="2012-11-28" version="1">MSGNSLEDRLRPAPTRPPFLSSQSSPALDASTGSKASASTFGSVKSSISRKKPLGLDISKSIPKPTRSASSLFGGPAVENSGDSNWIPEADRLRDEIARLQLSSKSSSSSYASGPDSPPLESPAPPSSAGAPPPRPPRRVHSGQTTPTTSTKQPITQDGGSKSSHSSHSSHATSSSRKHSKTNGKRKKNDDDLVKDEDLEVLADLGAGNGGTVTKVWNKKRKCIMAKKLILVDAKPSVRKQILRELQIVSECNSPHIVAYYGCFPSDVHVGIVMEFMDLGSLDHIYRRTGAIPIDIVGKVAEAVLRGLVYLYDVHRIIHRDIKPSNILANTAGQIKICDFGVAGELINSIANTFVGTSTYMSPERIQGAPYSIKSDVWSLGISLVELAQGRFPFADPPESGEESEEEYDPDPTLPVSAQRPNIPSEKRHRKRGVSLGGGGMTMSILDLLQHIVNEPAPRLSTAKKTFPAAAEDFIDGCLDKDPMLRRSPQELLESEWIRKSTVTSDQMQAWAESVRAPFPHTGIGRISEYALPLSLALLDLQRTVLPAASPWQSQLSPFLSDRFDVHDYANAVIQGRAYRPDDAEASATKTEKGDLGVEVARLNYAIDDVTRQLRQEVSVCPRLPELPSATPRYGVPTPAPIAADHSCELTSDHDIVPVTPEPPDDVTCAVIAAGADQVIPHVAVWKHRPIAQQDPRPARAARAVTSRFVLLARRLEAQMEAVRAAPKDAQGEGEKERELAKAALSVAELDALLAPGVSENEGEDGEGGEDGEEGSSGPIPLQTLDFVQAYAPLVDKARDAIITEMEAMVVSGLGSLNQPLLSSSLQTAHNLGLLPELVSNLVADLNDAVGQRVRRAFDSAAIGREVSGKDGGGIRFTTKRAQTEPSSGAAAQWQAVLWTRLEKVMDDVANCCIKVSFFCCAVELTKQVYTLEKVLKVKRDNVTQRSFLDEVLMRLDETPSFTFWTTLARAFEKQAKDAQKANGWLLQALSSGYPRLLRLFHGFFAQIAVATDTAYTQDSQSPSAVLVLRSVSAFEAAYLSRSSGRMDDAVKSAMAQYSSARQTAPGAAEGVAVARAVANELDAARFDPLLVRTVAGNAAKVLASLRSKVDANVVRDFTATSLIGPTATPAQIINASFASCMYHCALQLSKLSISSTVDALLAPAVSSLEASWRRITDALDAAIRKEFASILGRMHRIDWSKSLDPAQSMQGSAYMTDLVTKLSFLRGELLGRLALGSELRSWVLRLAQTLSAQFLSHASLLKASESGKLRLTSNMTELEMALQNFVNVGRIPGQRASASTRLEAIGDEYAALRAFRQLLFADLAGLKDEHLTHPLPVDTLCHCILARSEPPLTLSLPHQVHGWSEGEYVLWLSRHGDAEKRELIRKAVQGQSDGSEPAARMVLDVLKRAEDEHEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSL1</accession>
    <name>K1WSL1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01739</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSL1"/>
    <dbReference type="FunCoup" id="K1WSL1">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSL1"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_1"/>
    <dbReference type="InParanoid" id="K1WSL1"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000097">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="10">
        <location>
            <begin position="76"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="865"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114054" checksum="DC1FD187A2DC39AB" modified="2012-11-28" version="1">MSLAHLSRRAIRAPLRVQSAIRSRPFTAGAILLRPSASQPVNHSTTATQPHPFPPSKSYTPETTSIFTPLDTFLPRHVGPRDSDREEMLKALGYKDMDEFIRATIPDDVRIKEFTSSDIKPYSELELRRRQEEIASMNKPMKSYIGMGYHNAIVPPVIQRNVFENPGWYTSYTPYSAEQSQGRLESLVNFQTVAIQLTGLPIANASLLDEATAAAEGMAMCAAQVPKNKFQKGKNVFLVSPTIAPQTLAVLETRAPGFGIELKIAESNDAVAAEVDKLGDKLIGALLPYPDVNGEITNWEDVTKKVKSHGAKVVVASDLLALTMLKPPGEWGADIVCGNTQRFGVPLGYGGPHAAFFACADDLKRKIPGRIVGLSKDASGAPAYRLALQTREQHIRREKATSNVCTAQALLANMAAMYAVYHGPEGLRRIAGKVHGLTRVLAEALTQLGFTIKNKQFFDTLTIDTKSAGVTADQVHKASVEAGINFRPIDENTIGITLDESVGPLDLTDIVNVFFRVKGEKTVDPSFVDELSRKLDLSAEAALKTPIKSDLARSTPFLQQAVFNSHHSETDMLRYMMSLQEKDYSLVHGMIPLGSCTMKLNSTTSMVPLSWKEFGGIHPFAPVEQAEGYQTMLKEIEHDLSLVTGYDATSFQPNSGASGEYAGLKVIEAYHNSRGEGHRDVCLIPLSAHGTNPASAAMIGYKVVPIKALDDGSLDLKDLKEKADKHKDNLAAFMVTYPSTFGTFDEGIEEACKIVHDNGGQVYVDGANCNSLVGLTSLGRVGGDVSHTNLHKTFSIPHGGGGPGVGPISVKKHLAPFLPGHPIVPTGGDKAISAVSAAPWGSASINLISWSYIKMLGGAGLTEVSKMALLNANYIAERLKPYYNIRFTNKNGRVAHECLLDLQEFESKAGLRVPDFSKRLQDYSFHPPTAQWPINTCFLIEPTESEPKHELDRLVDALISIRKEVDEIVDGKQPKDDNVFKNAPHPLSVITAEEWTRPYTRTKAAYPVATLKRSKFWPAVGRVDDAAGDLNLICECGDVQSFVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0Q3</accession>
    <name>K1V0Q3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0Q3"/>
    <dbReference type="STRING" id="1220162.K1V0Q3"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="K1V0Q3"/>
    <dbReference type="OMA" id="CCCAFAN"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF36">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="531" mass="58114" checksum="2488F2FBA0E0A799" modified="2012-11-28" version="1">MADIEQKYDLDHNDDGTRSPTKLDYSHGDEPQFTMMPSEMPRWSKDSWILYLSVFCACCCAFANGYDGSLMTGMLATFGLKKTTGPVVSVIFSLYTVGSMLAAPFAAIMSDRYGRRKAMFVGAVVICIGMIVMVTSKHVAQFVVGRFILGAAISLMTVAAPAYSMEVAPPSWRSRATGLYNCGWFGGSVPAAAITFGCSYMGSNLQWQIPVILQAVCAVIVMFLVFIVPESPRYLMANGRDEEALAFLIRFHGNGNPDSPLVKFEYEEMKNAISLDGIDKRWWDYRPLFLTRGGRWRMAQVLMISFSGNGLGYFNTVIFEMLGVNTAAGQLGYNLLNQCISAFCAISAATVADRVPRRAILPLGTFICAVFLGINGGLAEVMGKQTARGEAVGDPTRYVSKAVGQGALAMYFLFNCAFSTTYTPLQGIVPVESLSTTMRAKGLAASGFIVSGMGFINQFCMPISLENIGYRTIFIFVGWDCVEAVCWYLFGVESQGKTLEELDYIYEQPNPVKASKKLRKITVTDQGVIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4S6</accession>
    <name>K1V4S6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4S6"/>
    <dbReference type="eggNOG" id="ENOG502SBFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035170_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4S6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851831" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="35"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="582" mass="60111" checksum="9A4316C2CA90169E" modified="2012-11-28" version="1">MKFLAGASLLVAAANAMPTSLGERGSDQVCNAARSVSIVVDSSASNKGTDPNNLRLVASTDVINGRNFQQDRVSVVSFNDQSTLRYALGNDKNAALQAIQQIDAKGNTKISEGLAQGLEQIINLGQDARDHAGVVVFTDGLDYTKPQQLKLLQKAKEAGIRVSWGHLSADEVHPKNGKRDVIGPDGQLEERTFGMLKNVMSSVISMFCGIGGGGSTGGSTGGSTHTGSGTVNQGGGSNIVVRPSSPLDQEISAACLSTGGTVSIIGNANAQQSFIQQVIKNGVTNNDGRCSGLDIEESGGLLKNNVTSLGLCSNNAHAEFTYTPEKTKEKLAFTVSLVSTANKVSLKAVFENTANGARNEILVNSQNPSLMLTGEANVGEKVKVSIQPNGASADTCQYSVGLIAVADELVQSASSSLVIEGTLIEQGTIVGEHTGNVEEHVSQTVSQGQETGSYSETISSATASQTATSETVSKTASSYTEGSSTVSSVTGTFPTDIISTSHTASSETVSSFTSSATSETISSQTISSATQSLECPTPSAQTVTQTETKTVSVTGSAQPTEAICLCKCDVKGAKPFPKVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V586</accession>
    <name>K1V586_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">A1Q2_06513</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V586"/>
    <dbReference type="STRING" id="1220162.K1V586"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_267477_0_0_1"/>
    <dbReference type="InParanoid" id="K1V586"/>
    <dbReference type="OMA" id="WHETIKA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="23">
        <location>
            <begin position="620"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="865"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="909"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EKC99109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137367" checksum="B810EB9D9F7BCCA4" modified="2012-11-28" version="1">MPDEGTVDAYKNITKLTGPENVRTWMQGIEGFARRKNVTRILNGSYVEPYRRHVPKGHPSYDAVYPEGGHAGDQPPTGMELQDDVEGGELNEEQMAKWEKWEEKENTARAAIIETSAKTLRAFIDEHWSAHEAYVALQEKFKTDTMDHKRSSKHKVTSMRLSEEATPATMRTHYDEFCDNVAESEATGLKWNDFDKCDTFLSTLPYDTQQYVQLMWRSRATLEEATFESLSACYLSVVESRRLQWQQEETVNATGMFASAKEQMNATRAGVKRGGAPALSSRGKKQRNDNDKENAGAKVGKCDYCGKYHPIGPKKCWTELAGLPSVTEAKQKINAIKKAMTEKKANDATSDTHSSDDGHIAAGVTAMALDSKDEGDFEYGVVTHVTGDDAEHIAQVTQTPQELISAIEGDTSTIEFENFLLDSGASVHIVNKLELLNNTRPLSRRFGQAGPGGIFATHVGNLTIALPNDEKVDVSPVYYCPDASLSLLSAYKLLDKGWKVKLEAAGGLVSYNDNKYRIEVKRYTSYMHVRVRRYHSKKDAKQRRKKHTSRTIGVFTVNYDLDTPLFRLHKRLAHLSRSALRRLAREGRVEMSEKEVIDDTFQVEQCWACMQTGFKKLPHKDESPRGTKLAREYVHADLYGKRDPTYDGKQYALVMTADFTKIRHIALLKSKDEAYTEVTNFINLLETQTGATVAVVRTDFGKEFVNQDFKRACERRGIIHQYTGGYMPEHNGVAERVIGTIKARMRAMLASTTLGPAAWGHAMLEAVNVLNMVTPSGVEGQTAWELLTGRTPNLAKIRTFGEFVFVHVPHGKAKSKADVTQPTARAARILGRHYARPGWVVRYEDNGEIGMSADIRTAAGVPIDQPLDHIPEMPPKAGPGRRPLPPRRILIHPSQRSCELKLPLWPWDNMGNSRGPAPSPTPSPSPRATPNPSQAPTRETTREPTAAAGDRGEDSGEPTPGARHEMQDPPTIEIQPPTPPPQPAPAQHQPAAQPEAPAPAEPGVQTRKSPRQPAPRTVPSSYEAATSSTAAEASDNICLLVTEEDSPQLTEELLVAAALEDGETLPEEPKSYAQAMKSPLAEQWEQAWQKEMETLTRKGTWREAKLPPGAKLLGTKEVFRYKFNAEGQVQLLKARCVVRGDWQRPGEHFNETHQPTSRASTLRLLCNLAATYGLELHQADFEAAYLNAKLDMPLYIKFPPGYKQKDPDCDCLELLMGLYGLKQSGHLWWKTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5G0</accession>
    <name>K1V5G0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5G0"/>
    <dbReference type="HOGENOM" id="CLU_738080_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5G0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="375" mass="40621" checksum="B4E3C08253E22EE7" modified="2012-11-28" version="1">MSQSPDLQECLAEAKQAAALRAQQASSSIPPIAIPLSLLVTEPHPVLVELQATHGGVPVPVSAAHFAACIEMARSIERACPSTHSATVSPTKPDLDSRVSRASPPPRLTGPVRRIVPLSDPPSHAKRFSTPATPSKVKPAGPTAEKIPPPPKDPRKSAKTACEVAAKFVEELTSVHPSTPTPKPDQIQQLQQRNTELEEELRALHSDMDLVDNKQKSQQDRLNELEDGVNAAHADIDELHGRLDTLNMTQKSSSSAQNLASLEAKIASLEGSLAAHKTTFDQFQAQISGQVSASCCSIESLTAEVTDLFENVYDAEGNNLVDVFAKLNEDFAEKQKAWAEWKESLSRRVSKLELGEEDDWVDAELKQPVDAELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V621</accession>
    <name>K1V621_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V621"/>
    <dbReference type="HOGENOM" id="CLU_1300463_0_0_1"/>
    <dbReference type="InParanoid" id="K1V621"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="212" mass="23109" checksum="37B612B6D40EAE1D" modified="2012-11-28" version="1">MARRPSITMGRRPMSALIASGVALIGCTLFFISVLSAPIKKTVCFVNVRSAEGDKVVDFGLFGACWWAHRGRYGHRHTPWQLGNSRTRADAQISVHVHFARVGMEAGPGPVGRARLPRPRAVQAAEALARPDLRRRRARLRGAEFESLDHAVDHQHARVPHRKFTPPSDLALSPLPPATTGVATADLPTVELAVGPITPKEVFQLDGTPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8E4</accession>
    <name>K1V8E4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8E4"/>
    <dbReference type="STRING" id="1220162.K1V8E4"/>
    <dbReference type="eggNOG" id="ENOG502SGYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1240087_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8E4"/>
    <dbReference type="OMA" id="GMYSAGW"/>
    <dbReference type="OrthoDB" id="2595773at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="227" mass="24201" checksum="D9C371F89E21C811" modified="2012-11-28" version="1">MAERIELRSIGKNAGASASRTTLPPAYTEQEPEPGSLGRNYRSAEERAKAAARPHEGAPDAASVYGMYSAGWFVVLAVPLLLMPRLVLFMAQGSDAPVKAGPLGVVGSGPIPSYGGNQHDTLTPLESFTLKMLGFGLLALAAISIFVVVPNYSPQAMPYRMPAVCVFAVLGCVTAFVGWNAPLGFMSIVLGLGNGALGAWGFWTVFFGEEKQKFGKYLKPNSRLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA10</accession>
    <name>K1VA10_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA10"/>
    <dbReference type="HOGENOM" id="CLU_2623751_0_0_1"/>
    <dbReference type="InParanoid" id="K1VA10"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851980" evidence="1">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="78" mass="8057" checksum="C3E867ABD58F20A3" modified="2012-11-28" version="1">MLLSLTTGLAILGAVSAHTGCGGHEIGARNLGGRVISKRQVADNVEGESRYRFSDLGRQASQAAATSSASYHISQQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAQ6</accession>
    <name>K1VAQ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAQ6"/>
    <dbReference type="HOGENOM" id="CLU_464756_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAQ6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="588" mass="65590" checksum="926F12744A2A24E4" modified="2012-11-28" version="1">MDSRLYPSTPLSSVATISRYPSPDTCETETDADSGPSSERSGNMRSRLTKRYLQRLARLDTRDPSVVTTRLKLLDDIGLERFQRLGPGVRFKASSLLPAGKSSARLKAIDSLPSPEKELAKIAFLARTRFGQALLPPVYDKQREYGTLLSAVNWLGIDRFKELAEEEYDLDNVPDLQRQHPDRQIVAIRASPIPVEEQQNAVAQVLKSTALGQHVLEFGSIPPLSEEAWEEAILAYIGGPERFLDTYKRPAFDVHTIPGIYDRPFAALVAQVQRLGLSMSDEERAYVALLSYSVIGKKLLDGAGLPQPPQSVRGRPLRPSKTHRTGAQQPLQSHVDLLNHIGRERFLELVEEPLFDLESIPGWETTGTAVPSRRRLIEQSSLSPAEKERALVALLAIRPTPFINEHELYREIIRRTPQYKRGTSGRASEYYFPKLLAEVGASRFVKLAQEPLYDLTAILTAKDTGKWGLNRKFERVRRSNLSDEEKERAFVSILARSRVGKRYLQEAGREKTKSGPRSLSKASAGASVQPESAGVTRFAVARLPFVDCDRRIRAMASCIALPLPAKPNFIQAAALFGFFVQATMSGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBE6</accession>
    <name>K1VBE6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBE6"/>
    <dbReference type="HOGENOM" id="CLU_1644909_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBE6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="161" mass="17429" checksum="BFBA18565670FDE8" modified="2012-11-28" version="1">MTGKQQPSQVGASLFLRVACHQAEFVVPRGLSSVRGSKQTRLWTSGRLLQSYAAGYAATGGPRKAEDEVYVDREFGPDEVDAGIWSSTDILEILEAQSRWKSVQCAALQDAGGRSVTLGGREAWSRENGEDASDMTVEDRDPVGRAGAARPWFSRAPDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBK2</accession>
    <name>K1VBK2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBK2"/>
    <dbReference type="FunCoup" id="K1VBK2">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBK2"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="InParanoid" id="K1VBK2"/>
    <dbReference type="OMA" id="RSAWDLC"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="427" mass="46274" checksum="D4AFB179D2FD8D47" modified="2012-11-28" version="1">MAPVATSTEPAAGKAKYSTQNIMELDHNYHPLPVCIARGKGATVWDPEGKEYLDFLAAYSVTATPTSQASTLTLSSRAFYSTGLGPFAKKVTEMFGFEQMLPMNTGAEAVETAIKLARKWGYQVKKIPEGKARVLSVEGNFHGRTIGIISMSTDQEARNEFGPFLEKVGPNVDGKVIRYNHVEDLEAALEAYGSEVAAFLVEPIQGEAGIFVPDDGYLKKVSELCKKHNVLLICDEIQTGLCRTGKMLCYEHDGIKPDMVILGKALSGGMYPVSCVLSSKEVMGCLKPGEHGSTYGGNPLGCAVASTALDVLVREDLAARSERLGKIFREGVAALNSPYVKQIRGRGLFNGVIIDPTVSKKGRGAWELCLVLADLGILCKPTHRDIIRFAPPLVISEEEIRRAIEIIGKGLATFDELDVIPLADRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBM7</accession>
    <name>K1VBM7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07512</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="13"/>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBM7"/>
    <dbReference type="FunCoup" id="K1VBM7">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBM7"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_1_0_1"/>
    <dbReference type="InParanoid" id="K1VBM7"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13" id="KW-0288">FMN</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="14">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="515" mass="56190" checksum="8056585D1A8A4B19" modified="2012-11-28" version="1">MLSSRPVSRSVRLGASAARIAKPLTSARTFASSAACNLATPADSTATPVRHYGGLKDQDRIFTNLYLRHDPGIKGAEKRGDWYRTKDILLKGDTWIINTIKESGLRGRGGAGFPSGLKWSFMNKPGWEKDPRPRYLVVNADEGEPGTCKDREIMRGDPHKLVEGCLVAGRAMNANAAYIYIRGEFIEEANAVQKAIDEAYAAGYLGKDACGSGYPFDVYVHRGAGAYICGEETALIESLEGKQGKPRLKPPFPADVGVFGCPSTVANVETVAVAPTICRRGGSWFASFGRERNSGTKLFCVSGHVNNPCVVEEEMSIPLKELLEKHCGGIRGGWDNLKGIIPGGCSVPVIKPDICSTVLMDYDDLKDNGTSLGTGAVIVMDQSTDMINAIARFSKFYKHESCGQCTPCREGTTWMQNMMNRMVEGNAQEREIDMLLELTKQVEGHTICALGDAAAWPIQGLFKNFRPEVEARLRQYHEKNGGVFFGGELEKNGDWQHAIPDSRGGYVNPQVNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBP5</accession>
    <name>K1VBP5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBP5"/>
    <dbReference type="FunCoup" id="K1VBP5">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBP5"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBP5"/>
    <dbReference type="OMA" id="GRICKVP"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000158">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="695" mass="76250" checksum="145459E8AEA4FC47" modified="2012-11-28" version="1">MPPYGGGWPAALTGVPGAWLAARQQASAWVASTQQPSISQIHLGRSLLPFLFLSTYHSGFAPPRLVLLTPSFVTTARDEYAAAMDEEYDVVVLGTGLTECILSGLLSVDGKKVLHMDRNDYYGGESASLNLTQLYQKFRNSPPPENLQLGRDRDYAVDLTPKFIMASGELTKILVHTDVTRYLEFKQIAGSHVYRDGRIAKVPSNESEAIRSSLMGLFEKRRARNFFLYIQGWKEDDPSTHQGFDASTQTMKELYTKFGLEAGTQDFIGHAMALWLDDDYLNRPAKPTMDRISLYAQSMARYGKSPYLYPLYGLGELPQAFARLSAIYGGTYMLDKKIDSINVDPETGKFTGVTSDGETVKAKQVIGDPSYFGAGQEPGAEGRIRVVETGKVVRAICILKHPIPGTDNADSCQIIIPQNQVGRKNDIYIAAVSSAHNVAAKDVYIAIVSTIVETSVPEREILPGLQLLGNVVDKFVSIIPIYEPTSTGQDDNIFITRSMDATTHFETLCDDVAQVYERAKQVIGDPSYFGAGQEPGAEGRIRVVETGKVVRAICILKHPIPGTDNADSCQIIIPQNQVGRKNDIYIAAVSSAHNVAAKDVYIAIVSTIVETSVPEREILPGLQLLGNVVDKFVSIIPIYEPTSTGQDDNIFITRSMDATTHFETLCDDVAQVYERVTGRPLELKKKEPAAEEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCX2</accession>
    <name>K1VCX2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCX2"/>
    <dbReference type="HOGENOM" id="CLU_103060_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCX2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="26103" checksum="F4F201F198C59DC0" modified="2012-11-28" version="1">MWWTNTADIREYETHTLVLVRQRLYHKKVTAHYAGVPSVPDSTGPPFQISPQLCCCEKKHILFKLELGHHLAVALANATCPLESAFQTVNSSYNWTLANEKYSQYNIDADKQDDLEVLLLVNANPGVDWGYTPGCYFLGTLDEKKVKQCEELGGMAIVNSRTKQVVDADVWFCGLPGNGYEHRGPQPNSTMVDRLASRISDSVITCTAPTSAAYRTSWSWVPMAFVALTSAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDC2</accession>
    <name>K1VDC2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDC2"/>
    <dbReference type="STRING" id="1220162.K1VDC2"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="K1VDC2"/>
    <dbReference type="OMA" id="RPKWYIS"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="501" mass="55416" checksum="920995D312D92A3F" modified="2012-11-28" version="1">MSQRPEPELAVTTLEPSWPEDEKAGHGSFSTESKGDAGDVVAQPRDDAELQRALRKVDRRLIPPLAILYLFSYLDRGSLANASIFGFKEDLGITTQQYNLIATVFFFTYGGMEVPGGIILSYVRPSLWIACICLAWGIVMTLSGLVQNFGGAIAVRLMLGVTEASFFPSALVLVGNWYPRMQVQTRISAFYVIGVFSGAFSGLLAYAIHYMDGVGNLASWRWIFILEGIATVLLSSLIFIFLPDDPTRSKWLTASERDAILANRAAEGQASKQHFEWKYLRQVVCDYKVWMCTWLAGSVNIVVFGFSYTLPTILVQMGYKAANAQLLTIPVYCAACICTFIAGLYSDRRQRRSDMIVVGFSVALAGLIMLYCLPKDRIPGVRYFACCVLMSGIYMAFPGSLAWNSNNAETAGKRNISMAFQLTLASLATAAGTNSYLAHEAPQYTTGFGFSMAMCASSILVALGLVWLLKRENRKLDEREREIVASGEPFDEAQVRFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDJ7</accession>
    <name>K1VDJ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDJ7"/>
    <dbReference type="HOGENOM" id="CLU_566427_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDJ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="515" mass="55493" checksum="5019D0095F9518FB" modified="2012-11-28" version="1">MPMHGQILNASRRRVRLLFTTNSSPFNKPLNQRMREDTPAQAVTAAVNDDLISRPAHAKLLARLVSDCNARLDASVAIAVAAAMAKCHEEVDNRLSHALATAEERHETHTATLVKQLANTQSIVNAQTAQIETLSALLKVAHPRLEGASLPADATALVDAAEARFSMALNAAESRFNEALTAVKVDTAQQLQAVRNFSSVSLQELQDSIQQTAQSAATTTFLSDVTPQARVATAVDGMKQVRQGPEACSRNNEESERDQQEVSDRLLANELACNKAIKEYQQLSKRVQALGTNAGRNNVSIMKAQQTLGERLRLLEETVSASNSERVGAVNGLRTEIQELRCAMEELASSPPTDQYAPSRTASTDSPIALVLDKVLELVGKHEAFFEFYGDRLIAVTLALAGGKISRLSPTGIKGVQATLRQVKHLSPLKIGDVAQHYIDRLERKRNAAARGKGEFVTTARNAGSDAKQTVAEQANEADEDGAENILLVEQDRGAADQVAEEGGSIGKSGCEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDN8</accession>
    <name>K1VDN8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDN8"/>
    <dbReference type="FunCoup" id="K1VDN8">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VDN8"/>
    <dbReference type="eggNOG" id="KOG4603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1422361_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDN8"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21235" checksum="541E8706DD6E5474" modified="2012-11-28" version="1">MKPYGKQTIFVYKQHDVLDSGELDDMDGKIKTIQASLDEKRKELKRLTQEQQELESSPPTADLQGAITRLNAENQAARASLEPPSESSAAPVSRAEADQIDKSWVKWRKEWTARRKIYTQLIGALEDGGANRAQLEEEKGIEHDDDDAKEVEESELCKPAMTQRPRPARQARTSQVLGKRPHGSVAAGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDY5</accession>
    <name>K1VDY5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDY5"/>
    <dbReference type="STRING" id="1220162.K1VDY5"/>
    <dbReference type="eggNOG" id="ENOG502S7AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101461_1_0_1"/>
    <dbReference type="InParanoid" id="K1VDY5"/>
    <dbReference type="OMA" id="TRTHRMT"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="17278" checksum="0D76A02600F47E0C" modified="2012-11-28" version="1">MAAAGKQAARNARHKPDAVAEASSGGGRSRSKVTSQLGMSLEEAHLILNTKKTDNMETIMANYERIFKANSPPEAPKPPPAAKEAVGAAAQAAAAQAARAAKKAPKGPTHSHYLQSKVYRALERIKAEAAAEGAAAEGAAAEAAAAEGAAAEAAAEGAAKAEAKAAEGAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE74</accession>
    <name>K1VE74_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE74"/>
    <dbReference type="STRING" id="1220162.K1VE74"/>
    <dbReference type="eggNOG" id="ENOG502RB8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478970_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE74"/>
    <dbReference type="OMA" id="QMNANAL"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="561" mass="60437" checksum="D09E09FD6D8B6E58" modified="2012-11-28" version="1">MSALNNTAPRFRNQQAAPQLPPVLPPGFTPTLDVPPRLANIVTPVATPLATPLAPPPPPPLHASPSNGNLHLAFRNSGSHTLGPTFSDEEDGDDSDFIAAKMAALGIDRGGRRSHSFHYTSQRGRTLSTQSSSTDLQRKVQAQQQLLQLQILKQQQQQAAAAQQAAAIQAVLLQNAASDPQQLREAMALLDLQRAQMNANALAQSNAAAALQQRAAAINAQSYQQALQQQILALQAQYAAVTGGHVVGHPSQRHTIASQLEAGTLRRERERERERSRSRPMSPLNDQQLRAAFENAPNAPMISPPIDSATGVGWTSSSRKGSMSAGEWSWNAPPRTSSTSTIASSRASSPVTATYPQQPLGRFARTRQDLAAAQAAAPGAPPLTALLSRYRQIDDDNESALSLSETLANSPTSEHPSQVNRFSSGSSSTQSSQNTRKWSVESRFSTMSTASERKWSVESRKVSSESDHTIKEPATYFDWGYHAPAPRSHSFSSPQLSPNKFASRVPVVEPTPVSAVMRQPYGPPHSADELSDKNFASSVRKKVSLNLGMLSRRTSGIETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE96</accession>
    <name>K1VE96_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE96"/>
    <dbReference type="HOGENOM" id="CLU_1679201_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE96"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="157" mass="16927" checksum="24A51436F27899FA" modified="2012-11-28" version="1">MPTDAMARPSALTLGPNSSFASPGFGGRSLRSPLDRPRTSPLRSSSLRSEISSDSDAEEEDQSATSSTSSNDSNDSAESEDRRPFALPQRTPRVRFSPMTPANPSANKSQPLARALLNRALTPNNAQPKKTTKIIVPTKTIRTTFELGLTSNELARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEF6</accession>
    <name>K1VEF6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">DNA repair protein REV1</fullName>
            <ecNumber evidence="13">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_03282</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="13"/>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEF6"/>
    <dbReference type="FunCoup" id="K1VEF6">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEF6"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_0_3_1"/>
    <dbReference type="InParanoid" id="K1VEF6"/>
    <dbReference type="OMA" id="IKNGMWM"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="17">
        <location>
            <begin position="490"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="226"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="880"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="963"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1110"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD02390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1238" mass="135243" checksum="9947C433CCB7F39B" modified="2012-11-28" version="1">MASSSQSFWEEALEIAETIDPPPAKRPRYELSPDTPDAGHEKEGQRHEPSSPLGFGGTELTFIPTHLRTHGATDGLEAHSYLQRAEYAANSFGDIASYMKNKDKKVQTQNRELAAASNLPQVFKGLTFYINGNTKPSMEDLRKMIVQRGGTVVPFLRRKRELDYVVAPVLTIAKFKELENYRVVREGFVLESVEREKVVDWRKWRLRAGNEQGLAGFVAPARSEVKKPLSVEQEPPQSCEPTPRPEPSPVTVAPLKVGGSLLRPLRKPSASQRPAPPPVKASPAPGPRSSVPAPATDTIKVVPVEPRTTLSRPLKTAALPPSTARSGPVPTPLQSVVLPDSSSFSPAKSKVTPARDAAPEVLVVPPTAEQLSQRDNASPVLRHSSPTPHVSPSRPRHGIQAPEGLPYDISYRSKEANRFAGRLMQDDDFRAMHTAERGNEAGFIDSYYQNSRLHLLSTWKTELRLLVAEARSSAEHVPTVLPSQGSEKVIFHVDFDAFFVSVGLAKRPDLKGKPVVVCHSSGGGRASTSEIASASYEARAKGVKNGMSLGRARELCGDDLATIPYEFDTYRKHSTAFYRILLGYADELEAVSIDEALLEVTGAVTARQMAPDEAEAISPDPAVCVAEQIRSDIRDATGCEVSIGISHNILLARLATRKAKPGGVYRLTTDNCDELLSELDVKSLPSVGHSMQAKLQDAFGTTKCGDLLAYSKQRLRGVLGPKTGDTIFNFLRGIDDRKLTPDKERKSVSAEMNYGIRFKNQDQALNYLQDLAVEVSKRLKAINVKGRHLTLKIMHRHPEAPVEAPKFLGHGWCETYNRSVGIERRGQATDEAIIIGEEAVKLLKAMRLDPTELRGVGIQITKLDHGPKQAEVEKGQGRLSFAKPDRKGKGKEVAIDDGDDAGESVGISSEPSPIPVPGEASPQPVTEAVSPAPEPREVVPVLPTQLDPDFLAALPDEIRQEIQEEHTKRHGSRSGSRSASRSGSHSPLPSPGPSRKSTLNPAAHITKQLRPKHKTQLDAAMIAQGALYGAWSRADAQTLQPGSAGPSRGDRSRSVSLAPSDDGEMVGKYRAAELRALGIDVDVFSALPEDVQAEVILQERQKARNLRLRTHSASPAKVRPPRQRSPQPVPTISIPVRSKPALFGAREADDVAAVLAKWVESREEGPNEKDTDRVLKYLCKCLGGFSGLDHVSQLLRDMKGVIRDVCAEDSAWWDTWHSLFHSIDERVREMHGTGLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEL2</accession>
    <name>K1VEL2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEL2"/>
    <dbReference type="HOGENOM" id="CLU_1116424_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEL2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="25509" checksum="9DFD9E1064BB4B12" modified="2012-11-28" version="1">MKELPTTRVPLAELPLSDYVRDPNLPLSPVSLPLKRPATPKAATATPKRVVVELDADELGTGRSPARRLFDATPRASKIARAPFGGNTAGGDGIASSSSSSGSSGSSLSGSGISGNTSVGGLAPSPPLRSRRGSDALPTPVSSTSSSTSSNTPSNGRVHDPGFVIFSDDDVLARPVSQLFVPVSDTDEENIPPEVEVEVEATPRRKRFEPSKLSTVTTSSSSSVVEEKEQPAMSGKQGMIDEADEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VET6</accession>
    <name>K1VET6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VET6"/>
    <dbReference type="HOGENOM" id="CLU_2016826_0_0_1"/>
    <dbReference type="InParanoid" id="K1VET6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="123" mass="12947" checksum="C123B5E009A859EC" modified="2012-11-28" version="1">MIRTTMLRHATRPVTACTGRQSSRRAPYPDVNSGTRSASDVLLMAAATFMAGYTGAGALVAVLGIPKIGGYGEPAGQTPSYSVEVAMSANRELGCHVESTDGISRTCTKPGVNQRQRVLYAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF16</accession>
    <name>K1VF16_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF16"/>
    <dbReference type="HOGENOM" id="CLU_824356_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF16"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="36683" checksum="A08FE2C36213A00E" modified="2012-11-28" version="1">MDDECDWESLGDVPLAFLEAYSYPAAVFTKRPSVPGAPYQAPEPIWWNEAWATITAEQRLTDCVNDGALAAFAEWLDSEGPGSFELCIEADGYPQSPLQLAQTPMPNATVVTSITTSMPPPIASPNLPTTSLPSRKSKHVLDDFSEFGPNLTHRSSKNPTPTPSRKRSPGLRTPKPPKSSATATQQGPNTEHVNGTPGDETESSSTPTNPMVARTGVPAAEPPDSEPATNGKAAKSRTEKRHQQGAAEKKPEIPRPKNHAPEDNFTRQELDIAMTGVAAEYHRLVDTTEWEKTRLGPYSEWSSALKSMMGICFASATQDSIWFRPMDSTDIDDIHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHF2</accession>
    <name>K1VHF2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHF2"/>
    <dbReference type="HOGENOM" id="CLU_266890_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHF2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1239" mass="131640" checksum="9E234AC44585216F" modified="2012-11-28" version="1">MPAAQRPPASDRFGPAIAGAFAPPSSDRFGAVGETVASDGFPKGLELRRIKPVHAPSSWKPSNDEELPGSHSATRGSAANSRRRQARTSTQSDVIKRPQPEDVPPVPSLTVTGPSSSTSAMALEAPRPIMRHRSSKVRFSSPLRQELKDLDDDEKNSPTATENKGTAELGLTSRPKRSASLAHRNRTTTVRGGGKVIWAKSVHCAPGPSEAGPSRTSARCASSPSTTATSVRRARSTGSMLTPPSGVPRRSPSQRQNAPRRQQSVRKAPPGLWGDLPATGTAPVRSASMGGRPAPQAVNDEPGGVDMSHAPKFSRAGLKRSSVIMPTPKGQRPPTIAIPSKADMDQIRDMNMNSPKEGRPPSCGPSRVGRTPSTRIGGLVRKLSKRGSPGVQRSASTGSRPVISTPVLNDITHMDVPGRPGFKVSLQHTSRGLQLQPVAADPKAPPSSYRPLSTTPTPRTPSEPSFRATSTTPTPRTAPTPPPLADTGFSGFQPLRAGPDEEPLEVASATPRRPPAMQMPVPVPTPPKPVPAINAINAVSPDSMQLRAGRVPVHTVPAPRAVPVRGPRPSSHLSTVSGVSGVSRRVSIHDMGEFGTLPNSSTASFVPSVGFMPPSPTRPSTFYASVPTRESIVPGYKTAAPEWEDPALLPSVPQRGSSLLARSVPGSPALKHIDDRAEAHRRSLSGSPRTRSFSSPTQAYFSSPSPTFSPPPLPQAPRVAGTPPAPIGFSAARSNFQSRPRSSLSARRSLTASVPAMLALDEVDEPLPGPESAPLPHTRGDAPHLPPLPQMGPLNMPFSRAAATVGPAGSRQRTSWQRRGHQASASFGTLYDAQRSRTSIRNHRASFHTAHSGMTAESFFTDEASTASTAHPLSTPDLLLADITADDGTAVGLPDLPATIPQSWSLPQMARLSLNHGPPTEPLPDLPPRFERERAERGDSGRSSEDESTPSLSNDHSQSGQSEEPFGVPLTPPFTPTPLPPEKEVLAEPAGSTESASASVTEHVLASCDEEPRKATRTPVIGYESTASAASAARVTPSGLELPVRRKVTITRRGAEKISSFPLSTPLVLGDVYQPTLAPATQRHRQDDEWSIASLATSDTHTTHASFRTFATFDTGRPSFDHRPPSWDARGPHGPPSFDTHGRSSFDQTRPSLDTCRPSFDTARPSFEYSADTHATYSQDHGSEDIHDGLEEPIPAFRKRGHRKQSSITSAMSVSSMGHEAAIVEVTRAKTAMAMELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHF4</accession>
    <name>K1VHF4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_02118</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHF4"/>
    <dbReference type="STRING" id="1220162.K1VHF4"/>
    <dbReference type="eggNOG" id="KOG0285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382259_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHF4"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12 13" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854153" description="Pre-mRNA-splicing factor PRP46" evidence="16">
        <location>
            <begin position="18"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="159"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="495"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="537"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="579"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="640"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="363"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD03535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="724" mass="78113" checksum="CA02F6D6D672D5AA" modified="2012-11-28" version="1">MATGVILSCVCIPSALSTAARHGQLADNYDEDLKQLLSSLRSKLDEIKGLQGEPRKASLKSVTDDLDESEEIVSYSAGLPAYSPLQIAQMEVEIPSMPVSIRSTFQTRLAQSKSEVEKVKKSVRDARAESNRAELLSGSGYRGDDPYQDDDTAFSTRTRLLAGTESLTDSSRRLENAQRVALETEDVGTGILHTLRGQREQLENSRNHLLQADSSIDRASGTLKKMIRKMYQQKIVTGAIIGILVLLIILILWSKLSSAARRDFNIDEVRTPPHNFGSTSTLLLIHPSPVMSAEVASGTPSEEKNLPPLSELVRRSTKRTRAVYNNDLVTPEDGLDRANKIKLATRLAGEYKDVQVLPPILQTQAPAGPKRPEAAGPAAGPVGPSAGPKLITGGSAAAGAGTEAGPSAGPVAPKSLVKFRHQQGFGAEGGQASSRLSQALMRKKEARELSRVISGHMGWVRAVAVDPGNQWFATGAGDRVIKIWDLASGELKLSLTGHISTVRALAVSDRHPYLFSAGEDKMVKCWDLETNKVIRQYHGHHSGVYTLDVHPTLDVLATGGRDASVRIWDMRSRANIFTLSGHTSTVASVKCQAAEPQIISGSMDSTIRLWDLAAGKSMTTLTHHKKAKWKCPEGTFVTNFVGHESIVNTLSVNEEGVLFSGADDGTLTMWDYATGLPFQHLKDIPQPGSLDAEAGVFCSAFDQTGTRLITGGADKTIKIYSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIL5</accession>
    <name>K1VIL5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIL5"/>
    <dbReference type="HOGENOM" id="CLU_727997_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIL5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="446" mass="47940" checksum="24581367539D916F" modified="2012-11-28" version="1">MRRQGVRVVELDPAVRALNYASGIKDACDVVSMSRSRPGSVESNCTDGGDEAGSELVISAASTVSSEKPTDRQTYLELAYGLKSFKARAGHLVYCRRRAACRRVRKTLSGKVEKLEQLALPVPEAWLEKHPALDGRTLYLYPRQAHRRPRAFSTALFTPRSLGPVACWRATREGSSEPAQAQRTDGAYGDHGEPVDSHALVAAPDDQDDHGKPLTESALALADAELAEWAPSAPTLLCEQETPLSYEGDLIDCGDADTRTDGAYGDHGEPVDSHALVAAPDDQDDHGKPLTESALALADAELAEWAPSAPTLLCEQETPLSYEGDLIDCGDADDPLRAIVGSGVGQGTESANDSARPESAISAPSSFGTVINPEADEDQENRKLREEVAESYAPRKSNSPRSTSNSSQSMISCASTSSNHRRGFCRWRTKYRIFPQSLTAPLGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIQ1</accession>
    <name>K1VIQ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_05109</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIQ1"/>
    <dbReference type="FunCoup" id="K1VIQ1">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIQ1"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="InParanoid" id="K1VIQ1"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="212"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="425"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="491"/>
            <end position="492"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD00621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="504" mass="55347" checksum="CABD7DBF9B3F041F" modified="2012-11-28" version="1">MPALPTWPPELSDVQRETLLRESSVWALAHGFTLLPPSPSDPPTSTIAAPLSLLPSPFPRAEYEKARRIQTAYNALYARVALDTAFLDKVMQDVAPVDAFQAELWSRWKEIRDDLAQPLQLGLFRSDYLLHTEGDRAEIKQVEFNTIAASFGALSQKAGEMHRFLAQKTEGFFQPPRSLLEDKSAYPLNRSAEGLAGGLLGGWAAYGRDKAAVLFVVQPGERNVFDQRGLEYILSSKGVRVIRMTFAELGANARVGPEGRLFVRDLEGAQDKQFEIAVVYYRAAYTPDDYKSAKDWDTRVLLEKSTAIKCPSMALQLAGAKKVQQELAQPGVLEDFLLGKDRPAVGLQQSLTQQDVDALRDTWTGLWPMDDSELGKEAARLAQEEPERFVLKPQREGGGNNIYRKDIPGHLAKLGPGEKNGYILMELIEPPQGVHNWLVRGGEGIARYADIVSELGVYGVALFGGDDSAAVNAEVGTLLRTKGRESDEGGVAIGISSIDSPILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJN1</accession>
    <name>K1VJN1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJN1"/>
    <dbReference type="eggNOG" id="ENOG502SCUA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548823_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJN1"/>
    <dbReference type="OMA" id="GSCHIAV"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="497" mass="54654" checksum="38D2AC6083173BCD" modified="2012-11-28" version="1">MPLYLSQHRVRYTSLTPPADKWRPKDLFNLQARIQRNLKDHKMHAVQVGQTWNRRCLPVISLDSDRLIIGAGGDILVHHLVPPSSTSSYSPSTSPQFPPLRSLPPSPTHQKKGKRDRTTYAPKAVASAHVYPLSNRSDSDIVGLHPLPSGEVIAAQFDGTLQRLNLSGQLRSTAHYQHPKEHIYALSGYDDHFLALSYGVGSLYSARSPWLPPIEFEFEERPWSGLLTSDKAFVGIRGEVAIFNLRPDGVEYAQSLRADGSSTPGTESDDGVIVIDSLDALDSALGRTARRSTPYSIALGNDPYTVLSAWHDGFARLHDLRTGSCEMELSDPWQDAPLYCASFLGENSVATGGSQHGIVSVFDIRTAKGYSVFTPEGKGSPVYGMVAEGGRVWGVSERRAFVCAWDESGDARGGLRAQDDLQEVYEEPNGHYGYGRGRGGGRARGRGRDGKDIPTAYRRRGGKWGWTVGYGEHAKETCMGYRHEDNGTTLFETKVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJP2</accession>
    <name>K1VJP2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJP2"/>
    <dbReference type="HOGENOM" id="CLU_1016319_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJP2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="274" mass="30757" checksum="2DD31D59E7F279D4" modified="2012-11-28" version="1">MPFTTSRTSANPPQLRISSDSSGSSSVKGSEYWEGGKESSQSSAISPPPPSHSVRPSVTGEQTFPSSQKYRPFWPLPRHPLHIAQWGARVGTRKWEAAEKVQDFETMVAVFAPAVLDAVLERMLKARDVRGEEIKRKVDGPTFVPHDGPPTFQEWLVMTNDFVCETYDVAPSLARVGTHCRAVLNAAWYPSFDSRYPPARYDMRRAIPLEELGICDPMSEANFSDVSHWAMEAYGLDSPPPLERERAPTPVEEIDEEEWEERLAELKEAGLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJU4</accession>
    <name>K1VJU4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJU4"/>
    <dbReference type="STRING" id="1220162.K1VJU4"/>
    <dbReference type="eggNOG" id="ENOG502S3QU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043701_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJU4"/>
    <dbReference type="OMA" id="KPGFDWD"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="297" mass="31101" checksum="13CACB807A262C13" modified="2012-11-28" version="1">MDTPLTGERLGEEKAFARRYLDQLSHRPVNYAADYSPPLSTRPRKVGVVHTEVRPPPEAMDVDAPRGEISGFRPALKLNVEASLSDSVADLKKQINAAGGPPADAQRLLLKGKVLADSKLLKEYDLTDGATIMLMAKPGGASPPAAAPAPSPSETLAAGAGAGAAAGAAAGSAGAKRDHPTLSPLQTPDPTTPDAKHARNKPPTPQLTVTTDGGEPGDLYENRGPPSPVQSTKFHSVVSDPTFWQKIHALCHDEFQHARDADDVFDTFLTSMKNRLTANEAAKIRDVVGVSGMGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKN4</accession>
    <name>K1VKN4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKN4"/>
    <dbReference type="HOGENOM" id="CLU_090088_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKN4"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29529" checksum="37DE96D5CE1ED821" modified="2012-11-28" version="1">MAEHPDPADPDTLTQHSVWHQGDFTLISSDNVVFKAPSRILLCVSDVLSDAAETSTGDKCVHFADPDIETSEVIERFLEFACQSDLKPEAKGNLDYCTDIGRFIAFLHKYECPRLLSYLELAVLKLLTRGVITVMDAFAIGSAADAPFLCVSALERGVYELKNDLHPPLVFGKMRPGRLLGSLSDGCPLDPATMSLAAGRITQSQHLWALNRVWSLCHDIPQTDEPQTDDEGYQCRPEATRLLQTIPEAFSLLLGTMVSASRSAGSSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKN7</accession>
    <name>K1VKN7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKN7"/>
    <dbReference type="STRING" id="1220162.K1VKN7"/>
    <dbReference type="eggNOG" id="ENOG502S8NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061417_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKN7"/>
    <dbReference type="OMA" id="VSQGWEG"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31373" checksum="920B71353A96A112" modified="2012-11-28" version="1">MGRFDAHDHLVKQGWKGKGTALKNGHLTRPIPVVQKKTLSGIGKDRDESIPFWDHIFASTAASIASSANGTPSASGASTPQAAPKPKPVSSMSIAARSSKEIAKRKLYSGFFRGKTFSEDNSEAETSEPEPKVTVTKTTIETVQVQPAASSSSTSSSSEKKEKSDKKEKKDKKNKSEKKDKESKKRKRSSEDKSKTVEDKEARRLRRRLRKEEKELSAARRALRKAEKEERAALKVERKALKAERAAMKAELASEKEKEKEAKARRKAEKAARKVGKVEKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKR7</accession>
    <name>K1VKR7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Restin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKR7"/>
    <dbReference type="SMR" id="K1VKR7"/>
    <dbReference type="eggNOG" id="ENOG502SBFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035170_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKR7"/>
    <dbReference type="OMA" id="ASNDECE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852207" evidence="2">
        <location>
            <begin position="17"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="507" mass="52746" checksum="04DEFF37B07DC56B" modified="2012-11-28" version="1">MKFFAVFTALAAVASAHPFEAIFGRDTCVNPNRVVTFVIDNSASNGYAKENIKGSDPNGLRFDGARKLIAAMTPGKDQASVVTFTTRSKVLVGNTDVGNIHFSNPDIGGLTTMEEGVKGGADQLHAAGNIRDRSAMIFYSDGRDSDSILRPKLVPGKLQALANEGVRIHWAQLNVDGEKRQPPGVAEVAFHSGGIYAEVNDAASLTKFIDQVLGKGITNGDCHNNGGNPGGPIEEGVITHGICSNNVQAVYTYTPQRKEKIDIDLALLTTKNKVNLNVVLENKATGEKKEGNVNSGNAKQTISVSADKGQQITVTVSPSNASNDECEYTVSLRTTADSTPEPSSSSTQPEPTPSSSSTQPEPTPSSSSTQPEPTPSSSSTQPEPTPSSSSSKEPEPTPSSSSTQPEPTPSSSSTQPEPTPSSSTSKEPEPTPSSSSTQPEPTPSSSSTSPEPTTSATSCPAPPEPTTQTVTSTVVTTVTAPAPSSTASVCICKCDAPGAKPMPKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKU8</accession>
    <name>K1VKU8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKU8"/>
    <dbReference type="STRING" id="1220162.K1VKU8"/>
    <dbReference type="eggNOG" id="ENOG502RB93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_950006_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKU8"/>
    <dbReference type="OMA" id="WFIPRQH"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="32974" checksum="2E1F14DB55A0A0F4" modified="2012-11-28" version="1">MSLSSGTLNLKFMQRAKARQQATPSTPGSAASTPAPTTPSAPSAPTPAQAAEAAAEAEKWTLPSRFKGTRPNAAAGPSRPKVSFVGSYLPFVEEAEVSGGRRTFGAVKTKAADEDDEEEDDEEDLAEAGVHGKADESMDEDEKPEDRTFRRPAGFGTKDKGAKEKEKDDVVRGLKRVSLKRESSPASSDDESVPKKRVKTEPQLVKKDKKKAHTPSASKHATPSTSKHATPSASKHTTPAGSKHATPATSKESTPAPGERKKKKAAKTDAGDIPPPPKAKGKTKEEPKNALDERERALKAAKKAAKKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKU9</accession>
    <name>K1VKU9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000318">
        <property type="protein sequence ID" value="EKD01381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKU9"/>
    <dbReference type="FunCoup" id="K1VKU9">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKU9"/>
    <dbReference type="eggNOG" id="ENOG502QVZ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302063_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKU9"/>
    <dbReference type="OMA" id="HVQCFIL"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="688"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="920" mass="98928" checksum="9F3CDEA936AAFAFA" modified="2012-11-28" version="1">MDAARFAAPGANAAGPSQPPQRQPAKKRARNSPDGPGRTATGTTGAGDLSKVRAFAACRACRQKKVKCLPGPSSGVNGNAACQQCIMSGAECEYQPTRDRAAYSRAYVQDLSGRVQQLEALQSRLLPLLNAFEGGKLENLVTAKTEPRSMSDDERDMNGDSRPHSPRGDDDDDEGRRYTQDDRGNFRWIGPSNTLSLLDSFDQEVKAQPSRVTYRPVHDSTRASSPADSAHPYFGPVAGAGVIRALPGVEEVTFPPRAEAEAMVDAYFAEVHPVLPVLLEPDFRRRLNRALDCAEAGDFGSIRAGFLAVVFAVFALGERVLVTSRAWQRERTKQRNNEPEGETIQPGDAEAGVIWFERSQVLHFSSYREVDLYQVQCLTLQSAFQSAVNDMPMSWLLASQALRVAQDIGLHVSLQVKQLGARVWWSVYGLERMISITLGRPVCVDDQDMDISYPLAVDDETLFNLGEALTEEAGNLPEEPADCTMSGFVALTKLAKIAGRVAQLLYRPNHSRSVSDQQWAENQQKTIDKLDRLLRDWLQNEVYKDASSSRPISLMSAALSNGYFAVLLTLHRNLLPSNPAFARPRPSPSSQSLAHCVDAARSVIHVATQSRVLVPVSHHLAVFCQYLWSSAVILLLCETRAREQIVIDAVGAHVESCHQALRALEPVWPGCRKLRQLLTEVEAQAKQVRAAAARPKKRPSSKDRSNSAKKATGAAPNAPQAQNWQQPQQAPPLTANQVYSLSHGGVNNPALAPGLDGTFNLFDVGDMNFDGLEMLNAFTSDAWAVPATQSPLEVGSNTGQTPTSTGPAAPGQTQSGSMPAPSAPVNGSGLGSMLNPSPGTASGPRSRVLGSVSSDSSAPLAGLPSPSAAATATANWFTAGLGQNAAPSPGPAPNELAEMWAQIAGNSFDWGADPNVPFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLD3</accession>
    <name>K1VLD3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLD3"/>
    <dbReference type="FunCoup" id="K1VLD3">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLD3"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="InParanoid" id="K1VLD3"/>
    <dbReference type="OMA" id="LCWYSDR"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="428" mass="47276" checksum="CC383877402A2A40" modified="2012-11-28" version="1">MPNIKPPKPVLIVGGGEFGSTTALELAKTTYKGQAHLITVLDRSATPPATDAASYDFNKIIRQEYSDPLYARLAHDAMDLWRQDWKEYYHECGVVVSVSSNTPQAKSGYIARALAANAAPGMQTPGLGAKVLHGLKEVEGFYPDIELGDFAGQDVYINHAGGWANARGATEAAVARARALGVKFVGGTASSLIKEGNRVVGVETDRGSYRADIVILTMGSWTPTLLPELSSTCLPTGQVVGVIELSEYEAARYRDAPVTRLIDNGFYVFPPALTASGWVMKFAIHQKGFLNPQPGYPSLPRTQLSRGYEFQQIPVAARQQLRKGLSRVYPEMAKKEWKASRLCWYSDRPTGDFLLDWHPVLEGLFVAAGCCGHAFKFLPIMGRLITDAMEGKLSEELREIWSWNGKQGRRDESRDFSEYHRLDQESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLD5</accession>
    <name>K1VLD5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLD5"/>
    <dbReference type="STRING" id="1220162.K1VLD5"/>
    <dbReference type="eggNOG" id="ENOG502RB82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442266_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLD5"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="71155" checksum="C7A212D329E76D76" modified="2012-11-28" version="1">MTADNVPADTPPPPPFRFITDLSRRPSNSSQTSAFSFGSDFSQSNAAPAHKDRWRTGVTPWSINVAPTVDGSSSSSDSPSSNGCRETPRPNVAQAKPEPISVARATPFLPGISGGIWSTTLSSSPHMSYSPTSTPSGGDDIRKLQERVDHLQIEKNMAIADNTRLSSEVHHLTTLSTGNFDMGVSPTESTFPPGSFGPSDSLPAGCEPGAVLSSAEASTYRPSQMIVDLILSGKLDYLRMDPRSEYDLIRPLVWTIAHQEPRSNSQAATLKMAANALGSRSTHITQHLINVILEWAKALCFTSNGNYLCQQLLEKGTTEDRISFIKVIQDDVVSIANNKFGAHVLVKAVGIKELEGLISDALIKYGIFESMQTGARKVWRPVSEDGHSTANPQYLGKCRSSNESDIFNKIKEDMCGRWADLSVSNEDACFKEVRVAFDFYDLDLHRRFLMISQLSPIVNTASEYLCVRQCLTPSFVVNKLLNLHEPMIKGVSHAILTAYPPLATNHHGVQFVEFVLSSSRILQRNNIVKYIEGLCSQKEGRTPALVAVANSSVGRGHLRASRRAQLDEPRSQYLPSVPDHSAQLTEWQRAPPQPVSNFGLVASSHHPEASSTLLLVAPEQQHPSTPLKPRLSSTFKRSLAIQLSILQHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLF4</accession>
    <name>K1VLF4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLF4"/>
    <dbReference type="STRING" id="1220162.K1VLF4"/>
    <dbReference type="eggNOG" id="ENOG502S0RX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008847_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLF4"/>
    <dbReference type="OMA" id="SETPEYQ"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1096" mass="118642" checksum="8FF02A9443475466" modified="2012-11-28" version="1">MSPPPSKAVIEPTTPSQRDASSSSADNDDDSPQRPFDIAARLGLDVFGQPDSPSASLMLTRTAETLHGLSQQLAELNLDEPASIVRCCCGSKAECPSSAARERWEAKLKLSGEIGHALLQRYEALERKYKRLEHNYELQRKALADSLRHVANLERANNTHMSKFADLTHSYEALEKRYVQATHSQSLTQQSLSHVRSELAKCRQTASAQTIALAASGGIEQRLAEAERRYEDTRDLQHAESRKLKEQLKWRTMAEDRIEIDEIKTARQRDAQELLANAKERLESLHSETSSPSETPEYQRTLEDLVATNTLLKHDTSELAHTLSQTMDENRALREELEELRSSRPPRSRPLSMEIRPMLASNKGHMRTGSIPATSSERAHARVSSAIVSEANWGHFRRGSVAPSFTSTSTTDGPSISSPGNGIEYSSFSSPMNAERPMSPDMRVSPSVRHRSSISSTGGIPYISNGVAKSKGPRPLSLRSNSDRRNLTKRSMGVSEAINEWPADDENGASNDPTSGEEPPSPDTDTFRHTASRKRTSVLLPRMTSPMGHYDSNSSGNGASPSEKTSETTDLDHKRVNRRTLLLLSRSTGVQTDPTDAEETPKPQRRPSHNSEPSVALSETPAGHSETSSLLGMSTSDRKGGVPQLTDLLEYLSKMLTQLRGVDIPTLNRRLKKQHLPGDVGHLSRSTIANLQTEVAELRHRFRSLLEVSDVSRREMTLLLKLLKDVFSDVLELQNVVNAVTIDPKLAKKLRREAFADPDAPPETTSGLGWIAAPLTSLFTAAQKPAEAPVVPATPSRDRIITPPAPPTRAAPKQQASTSATTTHISVEFGSSGPVRRALPALSQSVSDTSSVASRSVSAPITAGSARVRSRASRSDLMGIFAGAQPSGVSPAVRARVRHASSQYFGPSDRRIFSEPRERLSTIVDAVLDPGEGEEDVIPGDYEPPLLERTLRPRGLSDSSIRSSTLVEQPETSFLGSGIGFLSKGLYKIGEAALSSSAVDTTPATASAQTKSTQHLGLGQPRRPPLSSKGSDSTPALSIPTTAPSTAVSLGTSPGTLKRDFDDEDEIVIGGVLLSGGVGTPIVGTIPKASQWGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLP6</accession>
    <name>K1VLP6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLP6"/>
    <dbReference type="FunCoup" id="K1VLP6">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLP6"/>
    <dbReference type="eggNOG" id="KOG3282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_0_1_1"/>
    <dbReference type="InParanoid" id="K1VLP6"/>
    <dbReference type="OMA" id="RMDLGMT"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="202" mass="21174" checksum="CCFB1EED9931E965" modified="2012-11-28" version="1">MSTLRENVTAALAPIPLALALAAFVAGYGAHKALAPQTVVLAKPKTPRRERSDSVTSEGGTDTDSDFEDEAAANAADLGALKPGSDEIKLVLVVNDSLKMSKGKIGAQCGHATLACYETLAKSNARLVNRWKMYGQPKICLKAATTEDIDAMARHARSLNLCARTIQDAGRTQVAPGSKTVLGIGPGPARLINQVTGKLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM21</accession>
    <name>K1VM21_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM21"/>
    <dbReference type="STRING" id="1220162.K1VM21"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="InParanoid" id="K1VM21"/>
    <dbReference type="OMA" id="ETTVWRL"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="640"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="812" mass="89505" checksum="251642487068C7DE" modified="2012-11-28" version="1">MEAEEVLGPSRSRSKPKSKKREREPSPVAGPSTPGTPASQASQDEEGEEPADEHYNGLVGAGEYVMLRRQPQNPYDSNAVQVGHVPRNTAARIAPLMDARLITVEGRMIGQNLDGKHRFKLPMDMCVYCRPAHRPHLEPEFEWITPMGQSFEMLRRKGQDPNQSAFYDYGTRGGQASNSNDKHVEKLLKGLKQVSADEKAADDVMLPLLESPPGVASGELNVDLLPHQSQAIRWMIDHEHPKLPKIGEPAVQFWSKQKGKGKNSGYWLNAATKTPQEADPELGRGGIIADGMGLGKTLSTLGLVLATMDEEPICPLSVLSNWQKQIEDHVAPGKLTYYTYHGAGAKGVKGKDLVEYDAGIATPVKGSKQAKSSTKKGPLMKVHWKRVVADEGHILKNPKAKSKFEGRSRTNSLPVTKAFANLQAERRWIATGTPIVNSPTDLGTLLACTRVCTPLDKPEFFKSLVLRPLRSGSAEAGRLLQGIVGQVLLRRTKDTVDAEGRKIVELPPIEFYQCEVQLDPDTRKTYDEPGANVLSMLTRMRQLCLSSDLVPENYLEELQRPSPKGSAVKAVKLSKEEQDRLIDKLRQAVADQEECSRQGLCPMDRHELSMASLLELPPDLDLVPDDVTVKPAARSAKIAELVKYLRAFDAGDKTLVFSQFTSFLDRVAGVLEDEGISYCRFDGSMPAAKRREVIANFQTQDKSSPHVMLISLKSGAVGLNLTAASNVFLSAIEAQAIDRVHRRKTVRVFQLIAADTVEAKVLDIRAFRCAYIYLTITEKRKDALVAKSGTKADAAAKKKARFEDLKEIFGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMK0</accession>
    <name>K1VMK0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxymethylenebutenolidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMK0"/>
    <dbReference type="STRING" id="1220162.K1VMK0"/>
    <dbReference type="eggNOG" id="ENOG502QWD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032662_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMK0"/>
    <dbReference type="OMA" id="PSNQMFE"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44210" checksum="8BA7DC8F587BE609" modified="2012-11-28" version="1">MTIQYDPQAESERPVRLPDAPIQELGPGIKLQPPLSRRGHGPGVIAVLPSRLSLRPHAKCGLKTPLDPDPVQKWAEEGFAVVGVQLSANSDITETLAVAIAGLESCPDVDNKGRYAVLVYDPSAVESIVASMPSQPALVALIVHGSSPSWAPVPVLAHLPGDVDAEQESDSADMKICSYGNAESSYFVVPSAGPKAYSPTDAAIAHTRSLVFLRERLGGPYFDLEQIWEEHTHYEFVDRSVSKTMGTMVAEPYVNHIPTMTGGVGREALFEFYRDHFIFSNPDSAELTTVLRTIGADRVVDEFIYSCTHDRMIDWLLPGVPPSGSKLRIPMIAVVNIRGDRLYHEHIWWDQATALQQAGFLPTYVPTPQGKLRLPVGGNASADMLLDETAHESNEMFGPDWGVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMK6</accession>
    <name>K1VMK6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMK6"/>
    <dbReference type="HOGENOM" id="CLU_1031300_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMK6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="24803" checksum="1CAB64C11716D0FB" modified="2012-11-28" version="1">MPAPGPYNSKNLPPIPQTNPPYGGSDHSRTYFWNSSLPSSDIVCSVDYKNVTDSCCPFSFGIRDDYTTGCRMHNDTQFTQWFEKCTHQIWGEVTGRPQDAEPNCVSWDEKMQFTRDREMESTSAPKSGKGELECTTLGSYPGINFTQQCCGQVGGQLANGKDDRGNELCTVKNEMEGKWNECMSALHTYPLCHGEDGGGGMSGSGGEGSGAGPIGAAGSLVFVAAALAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMV9</accession>
    <name>K1VMV9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMV9"/>
    <dbReference type="FunCoup" id="K1VMV9">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMV9"/>
    <dbReference type="eggNOG" id="KOG1533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_1_1"/>
    <dbReference type="InParanoid" id="K1VMV9"/>
    <dbReference type="OMA" id="MWFGQLI"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="401" mass="44788" checksum="0F6D2610A8508E4B" modified="2012-11-28" version="1">MSSTTEDQPMTSSLPEHHASAFGQLVTGPPGAGKSTYCHGMYQVSIEAFDGANRQFLTALGRPVKVINLDPAVTDPPYPCAVSITELITLQEVMDEYGLGPNGAMLYCMEYLEENFDWLLNRLDEVLAGEGGNGYIIIDTPGQAELWTNHDSLKHIIQKLQKLDYRLAAVHLTDAHAITDPSKYIAAVLLALRAMLQLEMPHINVLSKIDTIGGFGELPFNLEYYTQVQDLGYLLQTLQDQPRAGGKKMKKLNEAMVELIEDFSLVGFETLAVEDKQSMMHLVRVIDKATGYIFVPLDGSTTDDNMHALFSTAARPMDYDVNDVQERYSAENKEAYDKFQEEQWEKEWAARHQAEAIKKAMLGQQAPQEGDAAEHDNADAQENPRSGRVQIRPRDFSDEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNI2</accession>
    <name>K1VNI2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_04709</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="13"/>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNI2"/>
    <dbReference type="FunCoup" id="K1VNI2">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNI2"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="InParanoid" id="K1VNI2"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="40"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="273"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="586"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="616"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD01022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="716" mass="81025" checksum="F0E2445D2D83F12A" modified="2012-11-28" version="1">MPQPPGAAWDSLKPGLTDWIAEVIAQQGWERMTPVQAGSIPRALKNQDCVVEAVTGSGKTLAFVIPVLERLVRNEHKYKKGEVAALVIAPTRELASQIYDVFNLFLSSIQPPEPEVEEGETPPPVEPAPYSLPTLVTSGTEKPYDTFLERSSNIIIGTPGRLANFLLAPRGLSAVKVSNLDVLVLDEADRLVSSPDHRRDVERIIKHLPKQRRTHLFSATMTDAIEDLIGLGLRNPVRIVVNLKDKRAKKEGEERRIPLGLQNTYTVCEPADKTLQLVRNLKREAEKHQNAKFIVYFSTGAAVDYFYRVLSKIPQLENFSLTSLHGDLPPRVRDQALSAFTSHPSSHLSPAVLLCTDLASRGVDFSDIDCVVQYDTPTDPKTFSHRVGRTARAGRSGKAILLLTKGREEEYIELLRVRKIPLVGVEPLGADLEPRTVSEEASVEAERVDPASLELMEEIRSLALQDRDLFDRGARAFVSSVKAYSKHEAGFIFRVADLDFNAMAIAFGLLRLPAMPEVRDWKKRDAKLKEKYEAAVAKDAEPSEPAEKKEGQEEEEKELPKYTPPVPFAEAEVDWDTYAYASRQREAARQAELVTKAANREKDAEEREKRAKKRKIEKELRSAWSNQKERKVARMDRREKRDLKKKREWERKQIEAGEEVERADVQLSKKKRKEQAEEDEDWEGDYKALRREVDEERTSRKGNKKDNIGGMFDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNV0</accession>
    <name>K1VNV0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNV0"/>
    <dbReference type="FunCoup" id="K1VNV0">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNV0"/>
    <dbReference type="eggNOG" id="ENOG502S38G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048121_2_0_1"/>
    <dbReference type="InParanoid" id="K1VNV0"/>
    <dbReference type="OMA" id="WFRFLWD"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38136" checksum="CC8D35165A3A33FD" modified="2012-11-28" version="1">MEKFSKWRPFLPIQAPSGSPALAALLPLSWLFGVARGLLLALLGLLYFLIVQLILTPLGAVGRPLASLLTAMLARLALGVLGYFWIRTETVSAKRGMRGVKQAIPAVKRGDLIIANWTSPVDVLYYAFRYNPTFLLPVFSSPALVDSAFGRGSGTGSASILPPSSDSRCVGYVSLSPLSLIARSGELPPVAADVGGQKVYKTLAEARRAASGPVVLFPEGTTSNGRALLRFGEGVINEEVGKDGMVWCKYIRHPAPTALTPSAAVSVPGPSSLFRLIAGLPLPREMAVRTLHPSAAPSSPSFLPSEVLNGLQGVKEDAAWRDACAVALAETGKVRRVPGMGWAEKASFLAYYNARRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP09</accession>
    <name>K1VP09_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP09"/>
    <dbReference type="FunCoup" id="K1VP09">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP09"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP09"/>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="257" mass="27582" checksum="CCC0D88F7BF49085" modified="2012-11-28" version="1">MALPALSGVEAAKRLAAYAAVDRHVLKGSKLVGIGSGSTVPYVVDRIVQQGVEANKDRLFFPTGFQSKQLIIDAGLQLGDVDQYTRLDVCIDGADEVDAQLNSIKGGGACQLREKVLADMSDVWVTVADFRKNSEILGQNWKQGIPVEVVPFAYVQVMDRLQKAGGAPVLRMGKAKAGPVVSDNGNFIVDCPFPEEMMRDPFKLLTNLKLITGVVEVGLFCGLAKGAYFGNEDGTVTIRTLTGTEQIKEVPAEAPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ10</accession>
    <name>K1VQ10_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ10"/>
    <dbReference type="STRING" id="1220162.K1VQ10"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351673_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ10"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000044">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="278"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="606"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="651"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="776"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="836" mass="84820" checksum="29A1A9C28FC481CD" modified="2012-11-28" version="1">MLTSLIAHQAPSPPPSHIIHARSLSSSYPEHEPQHRWADHWFAMARPAGRTSSPHAHGHGAASPPTRPSALPGVTPTSPRSSFLGSFMRTRSRAQSVTNAVAGAVRGHRVGSPTVEHPNPLSVDGGEVSRSVSSPQAGNGPSTSNGQDPVVIPPVDPSLRRTHRIRLVPVLETNRSFTFAPVLRKMGVMHVPPGILPSIAAASVSDTGPLVNGRPPPLILKIGRFTERSNTGANGANGAVTGGSPGVVGAAGDAAAGGGAAANGAANGTSPQPQPASVPGGGGGDIVSARAAFKSKVVSRAHAEIWCEPGGKFYIRDTASSSGTFLNHIRLSSPNVQSRPQLLKDGDVLQLGVDYQGGTEEMYRCVKMRVEIGRDWQQRGNNEFNPCSHVFHYKCIRPLLVQHHPGFSCPLCRTFANLEEDVETEDAWEIASRRASIISRRNSNHSIRLPPAGDSPNAAPREAPGDPSTSVGFGENNASIDELLAASSSQPSEDGRDGEQPPLARQTTAVGAAGAPGAPSAAPAGADLIDLRSTLGAEPEDDDMAAAVNAAADSVAADTSTTSSASPMSIAGGGSNHLTTPSRDREFTLNATTPLNDVFLSTLVLQPGGQGSESSLSHAEVRESPILEEDEPPLSPDSRGSRTDFESPMHSRPTSQRPSRPSSASFPPSRSSSNPPAPRTAASAVSAVSAGASGLSGLSGASSAAANGDSRAGSIATGSNASLSTPARDASGQLQIPSGPVSALSGPSHGVLGGSLGGGALGLAGTGTGAVGGLGSPLSLNSLNPSLNPSSGSSISESPFSTPLLVPGGGSERKEQGAVSAVSSLPAGPASPPQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQD2</accession>
    <name>K1VQD2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cation efflux protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_02867</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000275">
        <property type="protein sequence ID" value="EKD02831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQD2"/>
    <dbReference type="FunCoup" id="K1VQD2">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQD2"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_4_3_1"/>
    <dbReference type="InParanoid" id="K1VQD2"/>
    <dbReference type="OMA" id="FQDCASW"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005353078" description="Cation efflux protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="346"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="425"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59060" checksum="0B8352BA388EC286" modified="2012-11-28" version="1">MGLSRQARIITLLVIDTAFFFLGRTPRLEPSTSSPESLALTNPRSSSWAMLSARSPSSRTRSTCSTLYTIKLATSPASSANSYGWQRAEVLGALINGVFLIALCVTIGLEAIGRCISPPEITNPKLIVLVGSLGLASNIVGLFLFHEHGHSHGGHSHGPIALPEDDEEDEQTTTTGPKRARADSRSSLYQHPAETRAQIIEAARLGQSIDNDSFLGRSPPVHARMPSMSRRRTRNRVSRLSGVPGSNETFAPSSASAVEVPAAPSNTDGVAAASPASSPADLTSPRASQRPVDSTDSPRHSHDISTAERGGVDAHGHSHDDGHAHDHDDAHDHGDDNGHSHGKELGGHGHSHGNMNMHGVFLHVLGDALGNVGVIATGLVIWFCKGKWTLYFDPGVSFLICIIIFNTAIPLVKSASIILLQGVPNHVSLEAVRESIKIIPGVVSVHELHVWQLSETTTVASVHVLIRPEADYMEVANQIREALHAQGIHSVTIQPEFTDHDEPEEIAEQSCMIRCPPELCNTNTCCPPQLENVSENDGSEAASANGNGSSHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQH2</accession>
    <name>K1VQH2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQH2"/>
    <dbReference type="FunCoup" id="K1VQH2">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQH2"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039566_1_1_1"/>
    <dbReference type="InParanoid" id="K1VQH2"/>
    <dbReference type="OMA" id="HKFFDIE"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000104">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="298" mass="33722" checksum="6B94CC7BB6290304" modified="2012-11-28" version="1">MHMLTIAEGSPVSVTTFPTASSSADSTMAASNSQNPNHQPNQFTTDEYVLAYHGPLLYEARILLAENWNESNTLLGTTGPHYFIHYKGWKQTWDEWVPEMRLLKLNEAGFAKRRALLEAQTKKNRPVAAAAAEALAPLGKGKDAKGKKGESSRKRTRDAGLDTRPEVKIVIPQVLKLQLVDDWENVTKNNQLVTLPRKPNVRNLLDEYRARSTALLDEIIAGINLYFDKALGNNLLYRFERAQYVEQKRSAGDRPMSEIYGAEHLLRLFVNFGPFIAYTNIDTESLNILREYINDIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQN0</accession>
    <name>K1VQN0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="10" type="ORF">A1Q2_02777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQN0"/>
    <dbReference type="FunCoup" id="K1VQN0">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQN0"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_2_0_1"/>
    <dbReference type="InParanoid" id="K1VQN0"/>
    <dbReference type="OMA" id="INCCSVF"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="250"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="535"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="337"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="397"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="624" mass="68374" checksum="90BD350168A1A509" modified="2012-11-28" version="1">MAAPARSAAIQIVRPTESHKSEQPEKVKKGTYGRTTHVGPLCDPTPVSERLNLRILPFPGPGTWYGPLGAPTHLDTGSLYSECQIYVVSCSRHSEDSAQVNFPFLSTFADPSPAAGVFTTPTQTPEPKTLSVANLSAPVFVPKSSVDSPSASSTPAPQEWANAAPFTPPVSAAPAADAQPYAQQLRPPASQPGLVPPPMGFDESGGMGFDHADGVFLGTAAPPQRRVARHEATYANPGVSAGLPAEVHVYHNLVPLGNPNPPVSRVFHHPAPVYRANSTVDGHAYCLRRIEGYKLSNEAAFQAVETWRQIRHANIVGLREAFTTKAFNDNSLVMVYEFHPDSTTVADEWLNPDAINRRRQTGQPIPERIIWSYVIQIANALKAVHTAGLAVRCLDATKILITGKNRIRVNGVGILDVLAFDNQTPMPLFQQEDLLNFGQLILALCSDYVQPGQHIASSLEIIGRTYSPDLKNLVAYLLGKPTALKTIDEVLRLAGPRILNELDALQSYNDVLESDLGAEIENGRIARMLIKLGFINERPEFDMDPQWSESGDRYVLKLFRDYVFHQVGPDRKPVLDLSHVLTTLNKLDAGARSREKVMLVSRDSQSCLVVEYRDIYKCIESAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQU1</accession>
    <name>K1VQU1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQU1"/>
    <dbReference type="STRING" id="1220162.K1VQU1"/>
    <dbReference type="eggNOG" id="ENOG502RPVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015421_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQU1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="86630" checksum="EA2651F22CED2B35" modified="2012-11-28" version="1">MQSSYPLDGRYLGGRGDDGSPASPSGGSGKEKQERRPGINRTNLSGIQNTLTDLVQTLRQGMLSGGFNSSTLPSSSSANTLSYGHSPSASIAPRRGTEVGSSPSFNTRGTVNPYIGGPMDAAQRHSHATPGHSWAPSLATTKDRRRDKGGTDSLPPSRSGSEAPDDILGTEEIINPLGSMSKLAEAAVERAREEETRSEEDLGVTPLKRTHSRDHLGTKKARHGAQRTIVEAQGLPQTVTDVPKSKSKKAHTHSLLDVVDEGIVSEEEARELMAIYYQGSSHFIPCYDQQYDTWDSLKKRSPFSITTIVMVGARVRDGGNPTSTVQKLARLQAQKFATDTMFNPVARVEAVQAMAILSAFSDNGWLPGGHAVRMALDMGINRSFIKLLRGGMGKGKSPEELEEERPLVVQSRVWFCMAYGMGRPAILREDETIAHCRRLLEHPLSITSDARLISTVELTALRAPLHIELTAAPDVPIDHSTLHRLKQANADFDSWERYWDHVLAERFGKGKADFYRESLVVQRQYAELFVNSQLLRGIVNPADVANMPEEKRVLALRAMRNAQACLEICLHGENYRNGLRYAVHYTHVCAAFAATFLIRIARLFPAELDLRKTARDVEDLARTLSEIPAGRYARSLRLILRRARKQKVIPAKSARGSPKQTTAPLPEAHHPGAPAPAPSETAGSVGSEHTPFVPNLLMGASQILDESPSGSENREISEFDLLFAQENLQRSGLSLGEGESLPLFLDGHSLGGTFEEGDLAPFVGLEQFFLPVDIDSRLTDAAAAAAAGQNVLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRF1</accession>
    <name>K1VRF1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000299">
        <property type="protein sequence ID" value="EKD02057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRF1"/>
    <dbReference type="HOGENOM" id="CLU_829459_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRF1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="36747" checksum="E49D990715929E11" modified="2012-11-28" version="1">MHSFSMRLWSADGQLWELSLTKVCTQQQAPSASNADLISVDSQAHISEELDEEEDEVKSMDDNEEQMEGQDLGEDVQAEESEEDGSADDGQDQAEEEMEEEGDIESEDVEMEEEADEEDITMCDEESSPKPTTALDSDLSDDLSDGEEIQVVEQVKATPKPVTPKTVTPKPVTPKPVTTKPVTTKPVTTKAAKPVKTATTKAAKPTKQPVTTTTKAVNTTKQPVTTTTKPVTTTTTKAVTGKQKKTVTAKELKDRVKAAEKELEEVKKKKAECRKKKDMEQLAILQKEHDRLRKVISRGSNKNTLAGNPGITLDQLGSEGVTLKDFPINDDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT21</accession>
    <name>K1VT21_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT21"/>
    <dbReference type="STRING" id="1220162.K1VT21"/>
    <dbReference type="HOGENOM" id="CLU_957093_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT21"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="31721" checksum="BC541D6A2FF594B1" modified="2012-11-28" version="1">MTFRHPARGGVFYTVPLRMRARHHESFDVHVDTGSGKLWLYSSHCASPACKGMKGYSPGGPAFNTGEKKTTHFADGTRIAGTWATDYVEAAGKRMEFLLADRGSATLPPGVVGGLGLGLPKQGKAHRVLWAHNQRRVCALCFGTHGLGAMLALPPVANDGSHLTIGDYRWEVRLSAIEHAGRVLMLNRRVLLDSGTVASVAPPPDVEAFFSFFYQNVAEATAGEWTLVFAGGARVHLPELFSFRRHGHHERSLHASPSGFNSTWIFGLDVLTHLHTVFDADKRMVGLASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTW5</accession>
    <name>K1VTW5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD03002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTW5"/>
    <dbReference type="STRING" id="1220162.K1VTW5"/>
    <dbReference type="HOGENOM" id="CLU_2428625_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTW5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="91" mass="10063" checksum="FA2C69AC31E3438A" modified="2012-11-28" version="1">MSYDWSAKLIKKHQQKYGDKLDVNRIPQGEVQKEDIADALADAGRVCVLVCLPPKLMGPFCGPLTPTLEQGPLTGTLKELGLNSKQVWKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTZ4</accession>
    <name>K1VTZ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000347">
        <property type="protein sequence ID" value="EKD00138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTZ4"/>
    <dbReference type="HOGENOM" id="CLU_1074376_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTZ4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="259" mass="27264" checksum="BEAF777AA034700F" modified="2012-11-28" version="1">MSGRLFCAISKILAKHYTLRLENLEQDKYLDLASARFYTLDPANAVQPESVTEQPQSHGLSAGAIAGIAIGSVLGAMLIGGLIGFLIWRRRNTHRYNITRWRPRDRAVAPSAAAPCRLAGFESVPLSPSGSGRNSFSRNGSGLLVPPPESELATYASGSTASNSHGTNVGPSHGGGGSYGVGRRPRAPLIDYVNAQDAGPVPTTVTQVEMPPSYNPEWAESGSLASNGTGQGQLQQEGGEERNAPGRMNSIVRAAKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUL9</accession>
    <name>K1VUL9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUL9"/>
    <dbReference type="HOGENOM" id="CLU_2160191_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUL9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="11780" checksum="0B9D77B399149B09" modified="2012-11-28" version="1">MPCYEERCWFSGASDTTRGGVRSARKRMAAEAPIPSACPTADSGELKQSRLLRTLHESQAQGAAFEKGLSTTDSPFEQIGGFGAMDGQAHSGEGAVTMPCTSSDRLPDLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUW3</accession>
    <name>K1VUW3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_02412</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUW3"/>
    <dbReference type="FunCoup" id="K1VUW3">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUW3"/>
    <dbReference type="eggNOG" id="KOG0415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018791_2_1_1"/>
    <dbReference type="InParanoid" id="K1VUW3"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="245"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD03302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="56941" checksum="D41422FC6A7F36B7" modified="2012-11-28" version="1">MSVLLETSLGELVIDLEVERCPRICENFLKLCKVKYYGLNAFFNVSKDFICQTGDPTATGTGGESFESYAWLQNHEGPKPPRYIEPEITTKLKHKERGTVSMAVAPVEPPGCGSQFFITLADNIDYLDGKHCVFGHVIEGLDTLDKINDAFLDQEGRPLQDIRIRHVEILEDPFEDPPNMIPVPDSPLRAPDSGFARIADDEDPFKEMSEEQAEEERRKTAANSSALTLEMIGDLPFAAVRPPENILFVCKLNPVTQDDDLELIFSRFGKILSCEIVRDKKSGDSLQYAFIEFDLKESAEQAYFKMQNVLVDDRRIHVDFSQSVAKMNRAQLMGLNSGRGGRGGGRGGMRGGHRGGFDAPRQRDTGYGDRYERKRSRSPRRDDDRRDRDRDRDHRDRRDDRRDYDRRDRDRDRDRDRDRDRDRDRDRRDRDRDNDRDRRDRDRDRDRDRDDRRDRRDRDDRRDGDRRDDRDRRDRDRRDDRYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVF5</accession>
    <name>K1VVF5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVF5"/>
    <dbReference type="HOGENOM" id="CLU_564042_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVF5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="484" mass="53530" checksum="6DE06269193C6792" modified="2012-11-28" version="1">MLPHYHPSSPTPRPEGVVEALAASPPIARRRRLNSCSSGAGQITGIAGWRRAPRTRHGSTSSLGMGMQSTPAKRAKSIDTIPWDSKATRRTEKEAQDGLLEGQINSIEGSDAQEFPLSDNTPEQQRSVDPQTPIAQWQDPLETTSETLYEIYHDHEEPLKLGTSSAPVTPRSSTGGKRKRSNVEQTPRGRMSPPTALSFNTHNDDIVSPNDNEQRTPTVPERQALGRVASPRLTPRPKLDLPPSDPPWSSTPSVFHDESFPKPRYRDTSSPSPPEIPRRRYSSVPPWELPLKSSPPSPLQLAALLDDDFSFPSSVPLPEYDYNAEREERALRPDPFGFSRIAAMVAGELPMCRSSLMTGRTPQVFLPSSEGEELPVRAYTPPRFSSPPTSPADGLISTEADSVRQSSPLRDRGAAPRKKKHYWLGERIYKRMERASRSESESETDEPVAKRVRKSESSKNSKKTVLTSRATPEPDPVSGTRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVX4</accession>
    <name>K1VVX4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">COPII-coated vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVX4"/>
    <dbReference type="FunCoup" id="K1VVX4">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVX4"/>
    <dbReference type="eggNOG" id="KOG1692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="InParanoid" id="K1VVX4"/>
    <dbReference type="OMA" id="AESQTWY"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852129" evidence="9">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="190" mass="21313" checksum="2C6026359E74067F" modified="2012-11-28" version="1">MLQLLVAVLAFLSLSLAHRIDIEPGTKACFYETLNPEDRVGHGGQMDIDFYADDQVTAPNGNTIATQSKQAQGTFSTTATSTGRYTYCFSNEMSSYATKTVSFNVHGVLYSDTDEMGPVEEEIRDLASGLQLVKDEQAYLVVRERVHRNTCESTNSRVKWWAVAQIGLLLAMCAWNVHYLKSWFEVKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVZ0</accession>
    <name>K1VVZ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVZ0"/>
    <dbReference type="STRING" id="1220162.K1VVZ0"/>
    <dbReference type="eggNOG" id="ENOG502S13M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095018_1_1_1"/>
    <dbReference type="InParanoid" id="K1VVZ0"/>
    <dbReference type="OMA" id="GWRIDLM"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="161" mass="17683" checksum="F37F2B7BEF6C17F6" modified="2012-11-28" version="1">MTAIKPETSGYGNSYQGGAASSDPTVSSQALSNDPEADIYGYGNSEIPEGRVNAWESRFGWRIDLMAAAAYIGGPITALIFLILETQNDYSALLTTPLVLFMIITNLLIPLPAFLRTLIIIVGVGATLFAAYRAWKDAQEGLSRYWLPYIGERAERWVNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW56</accession>
    <name>K1VW56_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00912</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW56"/>
    <dbReference type="FunCoup" id="K1VW56">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VW56"/>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_1_1"/>
    <dbReference type="InParanoid" id="K1VW56"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="275" mass="29889" checksum="E0F55E3D4C24A84B" modified="2012-11-28" version="1">MDTLVAQLSGTQQREKAESGYGNLDARGGVAGMEVPGVPDPLAFLSLHTDSMSTNPAAKIKLAHGTTTLAFRFKGGIIVAVDSRATAGSYIASGTVKKVIEINPYLLGTMAGGAADCQYWETYLGMQCRLHELRNKERISVAAASKILSNIVYQYKGMGLSMGPALFYVDSDGQRLKGDLFSVGSGSTYAYGVLDQWDLSDEDAQELGRRSICAAGHRDAYSGNTINLYHVRENGWEFIDNYDLSELWYKYDEEKKNNAKAKKAQGSQGEPIAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW74</accession>
    <name>K1VW74_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW74"/>
    <dbReference type="STRING" id="1220162.K1VW74"/>
    <dbReference type="eggNOG" id="ENOG502S1B4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022491_4_0_1"/>
    <dbReference type="InParanoid" id="K1VW74"/>
    <dbReference type="OMA" id="MIQKTNA"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="99"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="572" mass="61627" checksum="56DD7581A62B8F7F" modified="2012-11-28" version="1">MSPRIGGGESDSGPIAPSGRSLRTREIGAGPSARGSSSRKPSLTKGATSTDRTGAGGDDDDGSEDSSDDSDDSSEHDELDENDRHRELSSSVAVENIAREDLVYRLEVIQQPQRARACGFGDKDRRPLSPPPIIQLRIFDKSGNPVSPNAIDCHRLILMIDLWNGDQTQQRSIVMHPGARQDQYALFTHTSSRQPSVSHGYSENQTSPFSRGPSARAGSTASQPPAAWQGGPHGDWNAYPTRPPHYGHASSSSYPPLAYGGHPPPPWQQSPGHTRPPSASHPPYGPPEEWHDARSASMSAPPPPPPPAHHDSRGWTPEGTPIQTPGDVNYPPERAGSGYPVGYPPPPGAEGPWRKDSGFGRDERAMVPGAPGAPPPGPGYAEWDRHYGAPVRPWGASGDDHWSRQHRYSQSAQGQSTTGMPFVTSPTPAPATMYPEGYTERVTSSTTPSASSHYSRVLVGSMGAVCQRLKDLDGNTGLFFFAHDLGIRTEGTFSLRFTLADLTSLTVQSVVKDQSAPILAREFSSSFTVYSAKRFPGVLPTTRLTQCFADQSVRLPTRQKRTSPTSASKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWG1</accession>
    <name>K1VWG1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWG1"/>
    <dbReference type="STRING" id="1220162.K1VWG1"/>
    <dbReference type="eggNOG" id="ENOG502QS8J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712100_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWG1"/>
    <dbReference type="OrthoDB" id="449091at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="43060" checksum="6DDCEFE811111FAA" modified="2012-11-28" version="1">MREHPLTHSPVLHQVRQNTDTAQPAVSFARETKYGDPFTTQLRASGAVWKRLPGTAPVQIAFPEVDWMLLRSDHGWAALQYEILMRSHVDVPEDMEVRIDSEQVVEYAIIPSNDPEPMVRWYVGDIYGFGSTPTGRHLSEEGPSNFARSVHLKKGRHALLVRGLYEIRMFGDPKDQPPKIKIDFKLWPRKQQSGLVLEPGVDMFPDILQGQYAGDVFAVGVRLPPNVEPVTIDIESEHAKAALPRYQLLPGQTRAIPDGRRTLRSVRRAWGLSDKTKAAGPAAETSGETNSGVGNPASKARGPDEIAFNPQGRAGLSKARRGTTRIPLYGPRPQSVLTLEARGMSSMLYDLHTDLPLCRAMHEVGWPAGRLGSTEQEQGAEMEFIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWW0</accession>
    <name>K1VWW0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD05006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWW0"/>
    <dbReference type="HOGENOM" id="CLU_2575556_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWW0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="81" mass="8834" checksum="E4F481972A14A897" modified="2012-11-28" version="1">MSLPNSHIEEAQAGVNIPGDDMVPEPVRIAFPPIPESYEVVPELGAWSDPPTVNPIARARRRNPPQPRRLPLRPPVLLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXF6</accession>
    <name>K1VXF6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXF6"/>
    <dbReference type="STRING" id="1220162.K1VXF6"/>
    <dbReference type="eggNOG" id="ENOG502S10Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026509_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXF6"/>
    <dbReference type="OMA" id="FATPDWA"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013130539" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="265"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="465" mass="52139" checksum="A68FB02E75EB5C48" modified="2012-11-28" version="1">MRLTVLATLATVASARPFLPDLTSADWAQIQSGFSVENLGSLASGIASGIVDKINGAQKAVEEYSGDDTQKTIWQQINDDSDNYSKLIKVLNFEEDHKKVIDKRQDGYRITFFAPNNDALKCPHHKDDDLEAAFINEQDIGLAQVSAAIDSLETMGGDDKDKKRKKEIFKKIAHYVLQYHVLAQDFDEQALAQNSTIATTLRGPAGGSAGHKLRLHIEKHLVPPSLKLNFHSTIKSTHNAQNGVWHEIDHPLYPPVSIFAEALMITEYLSTTAAGIQAAHGRHFIEWEYDHEKSRKNRPVFAGTPAATFVAPSNKAWDAVPEGLRRFLFSPMGRRALAKTFAYHYLPRQILFSETYHKAKDIWSEDEDEGVWEVDSFGDDPSFKRTIDAPTGLKGHKIKFEIEKKKLLPVEGAVKVSIKVEGKDLQVIDVPASNGAWHIIDEVLCPPHDDKHKHLAPRTWDNWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXM2</accession>
    <name>K1VXM2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXM2"/>
    <dbReference type="STRING" id="1220162.K1VXM2"/>
    <dbReference type="eggNOG" id="ENOG502SGY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322938_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXM2"/>
    <dbReference type="OMA" id="TMEIREL"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="896" mass="100874" checksum="EAD8B7D0EDF09FE5" modified="2012-11-28" version="1">MPPRTRISASTPNDVTAAITQGWTAHLESMDFAALDLSMKKATEGQLSRNTLTSYESYLRQADIFIEAYANARFSQCHDYLDYRESFERVTPYSKQMILTFLTIKCLGTSQPDPKTDPPQKRARVTRSKKAKPSTPEQDDKADEEAGQEEADEVEEFFAEEKDESSNDLHILPPEVNQSIQGLPALPALPASELPELQNDVAPGGGPSVARTIQASLRWRFYAKWGLDGNDNPGSHKEVHALVRTINKIYNRSGQVGQKRCLPLAYEHLACCVDFMDKEIARTHLATKGKDRKTFIEMLFMRAYMPLAWCLMARTMEIRELRNHMLYRHVPHKELKDRPDVLHTEVRLTFRKNNQANPHKANLYEIHDNPDEPAAHVLRPLDNWLSFVKSCSFQQMADDPEALVFPEFDAAESPKFDTYWNDRSFQRIFKTVIIGSGILVQRWGTGTFSSHSLRRGCAQHRAMHPNPRKRWTLAAVRWWGGWNPSESNDVLMRYIIEAHDRQQNYYGDSMDPYRAITSLNHPVNAPNGPDPENTARLGDIHLLEQQTQLSILELRQSVEKQIGMLANLVQGLAISLTSGNVRFGLQAPLPRDAPPPTPPSPSSSPEVPDEPESAGPVASGAPPPDDVPPPIPPIQLPYRPQVPGKPPPIPKANNVREAIRQCEVADPPFHPFPLKDWPTLNREWPKYRAVAVKWKNRMSLYQAFKEYANSDWFEFARLFGTATNPALERIRQRRGARSRLRRQQIEGTLEDDNDEDSSPTAQLPITQLPIPTVSSAVPASPPSDDISDYEAPLSPRTVQAQIQAAEAAEHQASSQEPATERPPSTPMEPEDPIIAGLREIREMSPDTLYNTQQAAISRTTRSSHGSVLATHPTPHVPSLPTTVQPTRRSKRKRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY29</accession>
    <name>K1VY29_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY29"/>
    <dbReference type="HOGENOM" id="CLU_967055_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY29"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="354" mass="39755" checksum="23AA53E4DCB65072" modified="2012-11-28" version="1">MDLQRARSRQYQRPPDVGAGSPLLSHTLRPSHAHLVQRADSRQRGLLDLLACGRLVSCYDSQYPAFMAAEDPGSTKEARAADDWSHLPAPSERWRESLGLVSRLTIQGPLLAKTLLLLWSVCRSNTALFPNVTERRICDSAQGRAIGRRLDDYEQCDIDPRHGVLLFNSPGCCSGGLSSDPALLHLPSAGFKDITLHSGVPFVSTLPKAWDSCTVYETRPDEVLDALRRDSRSDQPTDLETAAERLRGLDLCGSAREGGLDIGGVPELLYWGEVRYCIPDRLYESNEEDWEEYSEEFGEELRERFQILIKDWRRIAELVQCDDDLELVWDGKERDRAACVTVMSNGPGYQQVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYB3</accession>
    <name>K1VYB3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYB3"/>
    <dbReference type="HOGENOM" id="CLU_180254_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYB3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7842" checksum="B8D0FA6F3580444C" modified="2012-11-28" version="1">MGKPKRKHESDSDGEVKPNIRDDPPTKARKWTGDEYQLLLKLVVEKGTSEAFKSVPGRTYNQTRLAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYQ9</accession>
    <name>K1VYQ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYQ9"/>
    <dbReference type="HOGENOM" id="CLU_947283_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYQ9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="31134" checksum="83FA38B8BDC1E921" modified="2012-11-28" version="1">MMRRSTRKTSIVKREASLSPSLSEVPATSSSTIKQEFTELEVDVKAEPSPTKSRKRKRRDENDSKEPPPPKREARYRKSCVTTLVPGADMQMPQDGGGQESSTTAELTKVHGPPLWRGFLVWEHPRDVQHARFDWQHLRQFTLQAHPLHLPDELASIYASAPTSTDAIASEAVQRAFRKATSGADHDEEPTAQPDDRKVVAEGELVDETGPGGRRLTTIGDDCPMGTSSTCVWCRAPWAAPAPQTKGGVAHTRSGYTYHHHFVKGGKGKTWADVYAEGDELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W047</accession>
    <name>K1W047_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00543</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000142">
        <property type="protein sequence ID" value="EKD05157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W047"/>
    <dbReference type="FunCoup" id="K1W047">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W047"/>
    <dbReference type="eggNOG" id="KOG2927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_1_0_1"/>
    <dbReference type="InParanoid" id="K1W047"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="222"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="293" mass="32128" checksum="E4315B49DC38FAC0" modified="2012-11-28" version="1">MPPPPDATSVVDAQKRAAPELKAVADFLRGKNGPKVRRGVLNGKRVDFFKGKTAVRVLLGPQYQKLKKVPAVTNEQEAHELMTKVLPFGFFLRVDRPNVDPPPPSGVPKPLQLAQQQSFAPDVYYAWFYDGSPFWNIVGGIAMVAVMLAGVMFPLWPTKLRVGVWYLSVAALCMVGMFIVIAIIRLILWCITKVAMPKAIWIFPNLFEDVGFWDEPKKKKLRKVGEKRRKEKREKRAAAAANNAPVAPAGNDSPAPSASPAPGGSTATATGAEAPITHAHRRQATVEDVEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W065</accession>
    <name>K1W065_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W065"/>
    <dbReference type="HOGENOM" id="CLU_083702_0_0_1"/>
    <dbReference type="InParanoid" id="K1W065"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="285" mass="31670" checksum="7FA493D9D3FFC642" modified="2012-11-28" version="1">MRGLSSQAAPSLDPRFFPHITESILFFADYASLLSARGVCVSMCTLADKALSGDTIILKTGLRGRLLCEGPLGNLPFFHPRSKRALQLKAMASTQRVVITKTVSVTERLNSLLKALPATCHVRIEHGEVRDQGFCLPEIASLTITSLPVSSIPSDNCNCSRLWSRDWRHKAKQVLVECLAQKGTYYWDTPAFGRCQLIARALNAHVQLLELHSYEAHGFVADALSSRWRASFSHYDRVHHRNPGLAIVVRLKGPHNGGNSIADDFARSFEIDSSQVRVYSTQEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0E9</accession>
    <name>K1W0E9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_00512</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0E9"/>
    <dbReference type="FunCoup" id="K1W0E9">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W0E9"/>
    <dbReference type="eggNOG" id="KOG2263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0E9"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="15">
        <location>
            <begin position="7"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="14">
        <location>
            <begin position="437"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD05282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="770" mass="86548" checksum="F143F809162FE455" modified="2012-11-28" version="1">MAGAIKSAILGYPRVGTNRAAKKAIEGYWAGKISEQELQDAAKAIRKERWESIKNAGVDYIPSGDWTLYDSLLDHSFNFNVVPERFVKQGLSPLDTYFAMGRGRQDREKGIDVAANEMGKFFDSNYHIVKVDHSPNTEFKLARNQWLDEYKEAKDLGIETRPVAFGPITYLALVRKSRDAPADFKPLDLLDKLIPVYVELLKSLKEAGAKEVQLDEPILVTDAAEQWGDLYKKAYSALAEVGLPITLTTAYGRVGKSIDFINDLPISAFHIDVNREPGQVDEVISKIKDSKIILELGLISGRNIWKNDLKASKEIADKAVSELGADRVRISTSSSLLHTPLTLKVETKLTPEQVSWLSFADEKCAEVAALAAALNGEETEIYKQNGKDIESRREFERKSDPAVRDRVAAIKEEDLKRKNPFPVRREAQQKKLNLPKFPTTTIGSFPQTKEIRVARAKFGKGDLTKEQYETAMENEIKNVVDIQERLDLDLLVHGEPERNDMVQYFGEQLNGFIFTQLGWVQSYGSRYVRPPIVVSDVSRPEPMTVRWSSYAQSVSKKPMKGMLTGPVTILNWSFPRADISKEVQAKQLALALRDEVVDLANAGISAIQVDEPAIREGLPLRKEDWDNYLKWAVDSFRLSTSGVEDETQIHSHFCYSDFGDIFPHIQRLDADVISIEASKADLKLLQTFAEHGYSNEIGPGVYDIHSPRVPSQQEIQDRLVEFAKVINPDLLVVNPDCGLKTRAWKETEESLTNLVAAAKWARENIKAQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W183</accession>
    <name>K1W183_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/metabolite permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000089">
        <property type="protein sequence ID" value="EKD05557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W183"/>
    <dbReference type="STRING" id="1220162.K1W183"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366893_0_0_1"/>
    <dbReference type="InParanoid" id="K1W183"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="760" mass="84719" checksum="E0382B30D9DAF131" modified="2012-11-28" version="1">MLSHPNEHYVQLQSGGSASRSQQSPPPPMALMELTKPQYDVDEEKIKGGETQAERDAERLRTLGYDAVLGRPLGFWGNMFLSLTCMNPMFDVVVSTTIWAYQGPELFLLTGLYHAVRGCTSTYITLADVPAVSGEAPNWAVMEPLDPKLWWNPVFQIIIVSVVAIILMTRLSRRPSFWVVVGVFNIAVVIMFMGMYAAGAARAPQRRKLGFPTRNEWTKNFAYMIFMGMPTKFIPFDAAAHMSEETRNPAKNVPRSLYVSAAIHFTLVYATVACFIFALGVPLGEGIFTGSESSCVVALIGILGLPIKTVAGLAIIALALSASQFLATLVICSRFIFAVARDHGLPFSKYLKMTDRHREPWVANIVLVFIAYLSLTCWLYESKHYYQLSQAVSTYIPLVCYFIPMTLYLFSHLDLQYEGRSQFTLRKWGKPSAAISAFWMLLAIVQGFFPLCIWTTMYHKGIDVVSNKTPSYFPWAFIGMIVVMAVSWFLYGRRHFVGPVRAMTKWTAGVEISPEEERPNSRSNVLKAYLSGPDKDKDSGSKKDSGSGTPIKKSKRSSYGSDRAPATPVQQLAYSQASSNSEPAQAESQLLPDGQEGKRLSWYQRRDSRQPVKRRLDAVEEVEMSRAGTSGAQQESAIFPKSFAQEESGIFPSATQTQTQMSIAQQESGIFPATAADTQTQTQFSIAQQESGIFPTNTTRFSVAQQESQLMPSQVQTRYDPEATYLSMAQEESQILPDELSYPPPPTHRPYPAPPRRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1J1</accession>
    <name>K1W1J1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00065</name>
        <name evidence="4" type="ORF">A1Q2_00067</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000061">
        <property type="protein sequence ID" value="EKD05632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AMBO01000061">
        <property type="protein sequence ID" value="EKD05634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1J1"/>
    <dbReference type="STRING" id="1220162.K1W1J1"/>
    <dbReference type="eggNOG" id="ENOG502S2KW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987610_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1J1"/>
    <dbReference type="OMA" id="ITRYKYV"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="31040" checksum="99CC89FBE0D5F641" modified="2012-11-28" version="1">MAIETSPPLYTVKIVFHRAYSLPIADLPSRSSDPFISAEIRPAPPTSQEAEEDSSFSLSKLSLSSSSRRKSFTPDLAPPSSSPRRASFGRELAPPSAPSPRRASFTRDLFRTTSAESDGVEGMTEGDPPLRFRTCTVQRSLNPEWESEWIVAGVPSNALIEARVYDEDSWKEKDDLLGTAFIPLILNDHSSSEWVSYKLSKSGADPVALGIKAVVGAFDREARQGASLAVSVRVLGRTKRNIGRMYTINSHWWIHYSPLVGSITNTKTPGQLGDASEREHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2W4</accession>
    <name>K1W2W4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2W4"/>
    <dbReference type="STRING" id="1220162.K1W2W4"/>
    <dbReference type="eggNOG" id="ENOG502SJZ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422219_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2W4"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="649" mass="70237" checksum="849387E80B431F96" modified="2012-11-28" version="1">MATDDAVAATHRRSQAPNHPLTVAVYHVSAEVPVNDFALASDRTFPSSPSLTAEPRSIVTVEPRPVRPPPFRSRLSAKDSGKSVVVLEAKDVASCASGRNGGHIAPRSWNVLNTMTKPLSEGGAGLKASDAVDVYHFEMENLDYVEDVVKREKLDADFWRGHRLEVFTSEEGAKRNEETLDKFMRAQEEGRHKGKAMQCKVLKGDEAKRRARMQTATAVTTVPAGSWHPHRGVTGLMRRAMEQGVKLFSWTPVMSLHQQGGEGWIVDCGDRGKIKAKNVVLATNGYTRSVVPYRGHCGIVVPPTSYAGTGALDATYGVEDGPYLIQTPHAGLVLGPYNATVISQHLSKASELYGVDDDSVVLPKLKDWIANWCKDNYEGWGEEKSGEGLARVWSGVMGHSVDWVPLYGRVPGKDGLWAAVGYNAHADGTVARGPAPLLRDHGGEAPQCSQRDEPLGLLKSTRPQPTPPKALPVRREKSEVNDVTIQCPNAAHTDYSVVERFEAILAFAIRREVDGVVVAFRFQVVVVVVLAPDRSAIRVTWRWERGDLEAAARRPTASAPPADAVVSKRSSDSDSDSDSDSDSDSDSDPVSMPASSSVEASPSPNDPRPVSRCSPSPAPSPPAHFPFFSISLASHCEAASSIRVRLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4G4</accession>
    <name>K1W4G4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4G4"/>
    <dbReference type="FunCoup" id="K1W4G4">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4G4"/>
    <dbReference type="eggNOG" id="ENOG502SC9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077732_1_1_1"/>
    <dbReference type="InParanoid" id="K1W4G4"/>
    <dbReference type="OMA" id="SVHIDHE"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18961" checksum="7D660DFB1D43742A" modified="2012-11-28" version="1">MPPRRSTKQSSGLTQPTLSFQTRRPTRGSAKSAAKKAASPPVARRTSSSVSSAEPVTPAEAVVDLTSNKEPERPDLHPNSKQWDGLYKAAKQEMGGLPPIHAGPEVTKVHHILRVFDLTSKYGPCAGMTRLERWNRAKKWGLNPPEGIKDILETKQGEDDVSFRDPVSRDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4K7</accession>
    <name>K1W4K7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4K7"/>
    <dbReference type="HOGENOM" id="CLU_781155_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4K7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="355" mass="36902" checksum="0221F1706F64F006" modified="2012-11-28" version="1">MDIDTRAPSPASDTIEEIADPPWTDGSVPQANSNPTASPQSSSERDQSDVTCNLAALAGLAGSHGSGTSGRSAGAVTKVPASAHAPGPPTMPAPASLPPPLLNPQAAATAVPTPAQQPAPTGVHVCSNCNVAQPASTSMTIHPSQPSGSPSLLASIGRRSAGPAQTHSMSPSLLPAVPQRSTPSPPPSGDLEKEVRYLRTRLKEAEALSARLHGQLESSQQRLSKERQHHESITEMWANRVGVLEVDNQKLRARLGLGDKVPDMASGIMGEGRLSFGASKGHTRRTSKDVNAGKKRSPSSDPRRGTPPRHIDIDPPSLSSLSAGTTTTPKATTPRCQDVCPIQCSQQLVVGQEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W638</accession>
    <name>K1W638_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W638"/>
    <dbReference type="STRING" id="1220162.K1W638"/>
    <dbReference type="eggNOG" id="ENOG502QU6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517949_0_0_1"/>
    <dbReference type="InParanoid" id="K1W638"/>
    <dbReference type="OMA" id="SWIVTYV"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50212" checksum="AD1F1F051F692FA2" modified="2012-11-28" version="1">MSSVPVRTLSRSAHGACGTPYDVHRFKPLSLFKYHGSVAPGGDDLDSKETMAEEKITAVRMGPEVTDVEDKISGPVPGIVEPQETLNEKVIQQEPELAQRQPDEYTGHHHYVLKRLRRRLPPLSSRRKLAISVGPLFPTLQEYYGINYLVNRIGFGLVTPLGALSTAICFLLAGTGAPFGVFLVAFFFNGFGLSIQDAQVNNLTTRLPNPAVLMSFVQASFSGGATIAPFLSTAFAQHLPKRSYLYFFVAMGVAVIAMVIMLVAFRGMTEEQIVGTGDASGASTPTPTAAVETKEREEGVERTRSRTPPAIEDGQVAPADATVGALGEAAQLENSSGAKLKRILKRPAIYILMAWSFLYIAVEVGTSSWLTTFLIRERGASAAAGYAVTGFWGAMTIGRILLIPVTHKLGPQTAIFAYSIIALALEFVIWFVDSVAGNAVCYAFIGFFLGPIYPICELFSREEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8P4</accession>
    <name>K1W8P4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8P4"/>
    <dbReference type="HOGENOM" id="CLU_417485_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8P4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="657" mass="71862" checksum="5D8E7B7CCC3D78D9" modified="2012-11-28" version="1">MPTTPDALESYRAFEKTHFRTIDEYVKTAPENCDQMRQSQSTLISASSRSRSTSSTSLTTLVDSVGASSSSAQGTKMGGPSSSAASFKSFILGSRPRKAERPPDKAEVSINAAIYGASIHSQSSSLIFPVNNEHHSEPTPAPAPAPPPPSQHRRSVSMFSTRTRKTSSVSFSIGDKIETPSKPSASSSSTSLFHPGYSLLPATRSAPRFGGTVCESPMSSTLEVDRINRTSRKTSFKDNRRGSCPPVAFPASMAEEASETASIRSVPAPRSILKRSSDTASLRSFRAGDPTPSFDEARRTLEVYAEAAEEDEDDRSDVATTSSSLPAESIRKASPPASIMSTASRLSKMPKRAQTWVVDAGKGVTKSAAAMGTAILDTANPMRVQKRITLDEAVRPSRSQSQFAIADHILREKTKLPENQRDAASDYHMWNAERLNLNWKMKNKERVNVKEEIVEAEEEELSRPASVISLGGEPLYMTDSSAWLEHCDRVWDFTPQAVDLVNPHRPTLTKRSATLPNPPTQERITFTRRAQSEPTASQAAQTTADLKHLRTTSPEDIRASEDSGLPDTRFFKEDGKEINESPKSSLLLTPVSSNDPDAPGATWSQESLTSTASSSTEDLEFKEAKTELDWEKYPRLCDTDELDDELYNAVLNMTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9P0</accession>
    <name>K1W9P0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9P0"/>
    <dbReference type="STRING" id="1220162.K1W9P0"/>
    <dbReference type="eggNOG" id="ENOG502QPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_0_1_1"/>
    <dbReference type="InParanoid" id="K1W9P0"/>
    <dbReference type="OMA" id="FAGQNSC"/>
    <dbReference type="OrthoDB" id="2594565at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852804" evidence="2">
        <location>
            <begin position="17"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="119"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="540" mass="56421" checksum="93369C3B244C535C" modified="2012-11-28" version="1">MKAAVLLPVLALLVSAHPGEDHRIEALERRAALEFVGKRSLAHCAGALAERGINARNQMRRRAFLEAAAEHQKLRKRSFDDVLNKNHKSNLTGISKDTDPAELFKGEHLCTLHPETTEGPYFVKGELIRQDVRDNEPGVPLYVDIQLIDTNTCSPLSGAALDFWHCNSTGVYSGVSASGNGNSDGDDTNLDATFNRGIQETSSDGVAQFITTFPGHYTGRATHIHIMSHSPGKWTKLANNTITGNVQNSHVGQLFFDDSLIAEVEKLAPYNTNTQPLTTNKEDFIMAEESADVDPVVEYVLLGDSLEDGILAWVSVAVNASASYTARPAVNYTEDGGVVNPGGGMGGGPGGGGPGCGGGPPPGMNLTGGPPMGMGNGSASGPGGNGTMGGFGGMKCDNSTDNSTDAGATGSAPPTFPGSSSSGFLVSPSATPSAAPDVSSEAIPSPTSSAGTESEGQTQCTGRPGNGTHGHAGNHSNHGNGGHRLPAPGQKMRPNRHQAHWEYKEQSKWRQQQAEDDEGSDSDSDSDSDSDSDSDSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9T5</accession>
    <name>K1W9T5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9T5"/>
    <dbReference type="FunCoup" id="K1W9T5">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9T5"/>
    <dbReference type="eggNOG" id="KOG0624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015935_0_1_1"/>
    <dbReference type="InParanoid" id="K1W9T5"/>
    <dbReference type="OMA" id="PFAHFQH"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852730" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="409"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="531" mass="57327" checksum="3594E6BFC743619F" modified="2012-11-28" version="1">MKVLYGLTLLALLSPLPVSADAGAGGKSAAELSTEGNRLLAAGKYSDAARAFGQAIESDPSSYLNYYKRATAYLSQGKQAAALDDFNSIIEMNPKFAQAYFQKAKVLAKEGDLDDAASAMKQFSKLKPGDEAGTKLSSDISSAKSALKAAQNAAKKKNWDDCVAEATKAIHVSPNNKGVRELRVRCETERGDAETVFADMTRLAALDPSNLESHVQLAQLAYYLIDPASALNELKKCLHSDPDNKACKKLHRAWRAQGKALQQAHNFVNGGKPRKAINLLRGTQDEPGLIPSFEAALDEAVRDGLIAPQFAAKEKSAPRRELLALGCRATVDAQDFGSRAGKQWCEALLALEPENESALVFEGERLLKAEEWEGAVRALQKAFEKNRSQAILQKLQKAERLLKVSKQKDYYKVLDVPRDADERTIKKAFRKKAKENHPDKNGGSEKEMQAINEAYEVLSDPELRARYDNGDDPNDPTGGQGGNPFGHHGGGGMPFFFQQGGGFPGGGGFPGGGFPGGGGGGGQKFHFQWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDJ7</accession>
    <name>K1WDJ7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDJ7"/>
    <dbReference type="FunCoup" id="K1WDJ7">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WDJ7"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963740_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDJ7"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="128"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="279" mass="30131" checksum="3E76CE4DCA8111FD" modified="2012-11-28" version="1">MEDLSKARVAIGSIGISEEKRTPFPIATDLPGSLLAETGLHLPPPRKPGCPMPSPAEGGIRWEMGTHRVSRLRPQLSQRYRFTFKANPSVSAIRSAHHVLPRSPRLPLDVYVTDNYEADTPAYSSAPIAKGAKLPSVPVRIKDMGTEIDLSTQPGKNIIVTVPGAFTPTCHSQVPGYIALADKFKQKGVDGIYVVSVNDQFVMNAWKKDLGGEGVEFTSDSQAKLADALGLGWDVPPLGGTRFQRAVIVVQDGKVVDIKVEPESGKSTVTQAEELLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE01</accession>
    <name>K1WE01_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE01"/>
    <dbReference type="HOGENOM" id="CLU_1289758_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE01"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="214" mass="22970" checksum="ECE6F79737BB290C" modified="2012-11-28" version="1">MSPATQDTAPTPSAPPFATSASTSGERPAAVSSAASLPLPLPTTNTIPGLSHDAVVARNGRGMNSPIELMVFGLPHHHMTTAKEVLYRALQSINLPNIDPTTLKLTAGPAGAEDGGRPSSVRISWSGNAWYESLERPIDLMAEMENVRTQLSKRFCAQWASAPGVDQRCHGRFQLDAQEEGIQINANDAMEWARIFELCPTLPSSVGSLLKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE19</accession>
    <name>K1WE19_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE19"/>
    <dbReference type="HOGENOM" id="CLU_1826655_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE19"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852451" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15292" checksum="CBABF97283214D7F" modified="2012-11-28" version="1">MVAITSLFTATMGLLATAASAAPATPASDHRLEARYGLTPELFLAITRYVQENPGAYIFGINGWRDYWWFEENMKGFAGGNCHKSPDGSVMSGTLRPARTMWVCHGGGWFPNYQQAEKEGLNRVCPDANGCGVNDGGLWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE38</accession>
    <name>K1WE38_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid aminotransferase, Bat1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE38"/>
    <dbReference type="STRING" id="1220162.K1WE38"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE38"/>
    <dbReference type="OMA" id="RGWIIEI"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="409" mass="44967" checksum="CEBA4358B3CD4611" modified="2012-11-28" version="1">MSTQQAPFKASPLYFSPVSPSHQPAPGKEAYGRLLSGTAYVFCRPQEFPVLTSQTSGWGQPKIVPRAELSLDPLAGVLQYAVTCFEGMKCYKDEEDKLRLFRPMKNFDRLKRSAARLGLPYDWDNEELLELLSKLVALENPIVPKGDGDNLYIRPTIIETSESFGIKEDAYASSALLYIVTSANLGKGLYSSAEGPGLKLDACDKFIRAWPGGHGSYKLGANYGTVSVAKKPGFQMSLWLHSDGKQHYISEAGAMNVWIIKKAADGFLEFTTMGLDNGIVLPGVTRASIIELLQDHADGKAEFPLPGMPKNIRVVERDIPMAEIVEGSQDGSLVGMFGCGTGVVVTMISLIRYQDKDYEIPSNPLIKLIRDAMTGIQRGKVERGDWSYVVPEWDGTAREHDTDGQKVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG98</accession>
    <name>K1WG98_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG98"/>
    <dbReference type="STRING" id="1220162.K1WG98"/>
    <dbReference type="eggNOG" id="KOG0670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_5_1"/>
    <dbReference type="InParanoid" id="K1WG98"/>
    <dbReference type="OMA" id="GKINHRM"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="390"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="722" mass="81392" checksum="CA241462F2B7FF22" modified="2012-11-28" version="1">MPSSGTKRPAPPHLDERNERRDRPRDWRDAHFADRDGDRESSRNGHRRDERDRHDRHAHGHRDRERRDVGYDRRRNHRRDDRRHDRTPQRSHEREEGEIESPPRDARRLSPHRSPIKSPVRSPARQPVSIPSDPRVKEKESGRTHDPVKIAVPPPAPAADEPEPEPEEEMDEEKRIEERRKKREALLAKFRAGEGPKPSIPGSPARHSAAQSPASNGPGTGTNTETGATPLMQNLATSSHAPSPNTVNPSQAPTPFAGEDLAKPAGAEKSDRDGVSAAEYNERAKGGDKEMPADVEKKEDEWEEVEIEVSDDDDEEMDMFAAFGDEETPKKKRKVKVRRRKGANGTEAIEYIEKKPKSAAAAALEVVDNVDDVEGYYRITPGEILDDGRYQITVTLGKGMFSAVVKAKVLKAVGQERHQDVVGREVAIKLMRSQESMYVAGRKEAQVLKLLNHADPGDKKHIVRMDRTFEHRGHFCIVTESMSMNLRDVIKRFGKDVGLNMKAVRAYGHQMLLALSLMRRCNIVHADIKPDNVLVSENKAVLKVCDLGTAAEVSAGEITPYLVSRFYRAPEIILGLPYDTAIDMWAIGCTLYELYTGKILFPGRSNNHMLLCMMETKGKIPNRLIKKASLGHDHFDENMNFISVERDRITGADVVKTVVINKPSRDLRSRLMPSSSAQMKMPEAELRQIQQFIDLLDKCLALDPLRRITPREALNHPFITGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGH2</accession>
    <name>K1WGH2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGH2"/>
    <dbReference type="STRING" id="1220162.K1WGH2"/>
    <dbReference type="eggNOG" id="ENOG502T6JY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214700_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGH2"/>
    <dbReference type="OMA" id="WARRECG"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="255" mass="27609" checksum="87D3C2C39D796292" modified="2012-11-28" version="1">MSASTSTKLDRSSPEYKRSLTEALRWDHDRREPYLLLPTGDRIVPFRPGIASDIAALFNSPEIGRRLYRLPWPMSVAWAEDWVQGEIEKQEGYLAELVESLPSAPEPLSEDGGLGSGITQGEGLHKAPGTRALSGMPFKSIRDASGKIVGDIGLTPSDADPDTYTADMWHLGYVLAEGATGRGLMIAAVGAVLAWAKEWMGVKAIEAIVENDNPGSIGVLLATGFERVGDTVTDWPEEKGGGKRYGGRWIWKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIP0</accession>
    <name>K1WIP0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIP0"/>
    <dbReference type="STRING" id="1220162.K1WIP0"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="K1WIP0"/>
    <dbReference type="OMA" id="PADHIYM"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="565" mass="61448" checksum="1EB9FE915767B0FD" modified="2012-11-28" version="1">MTRAGYGLADTGRGNFVDASRSRSRRLILSQKDMVNLRIVEDRPTPKQVYGWRPYFCASIACWASVLIGYDGEFGLDKSRSDFLSANIVSCYQAGCFFGALSGYVLGHYLGRRWGMLAACVIFIVGGVLQTVASASTGLGIMYAGRAIAGLGVGICSNLSPIYLAEISPPAIRGRLIGIYELGWQIGAVIGFWVPYGVALNIAPSMKQWRVPFGVQIIPGGVLALGTFILTESPRWLASRGHGVKALKNLAWLRNLPRDHPYVVEELAEIEAAIRSDEANAGPGIAGPMKTLFTSKKYMYRLFLSVMLFAMQNGTGINAINYYHVPDLHQSLQLTTDAPTVFKSIGVSGTNTGLLTTGIFGLVKFAGAVVWLLWLVDHVGRKPLLIGGSVGGAFCMYWIAIYIAVADPIAHPSTTLSPGGTSALVAFFVWTIFYSPTWNGSPWVFGAEVMPTFIRAATQAFISASNWLFAFLISRFTPQMFSAMGYGVYLFFASLMVCSIPIVYFIIPETSGIPLEGMDELFALPARKAHGIVKKQLIALHAERSAVQQVEKDNFDDLFLKEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJ31</accession>
    <name>K1WJ31_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WJ31"/>
    <dbReference type="eggNOG" id="ENOG502SAX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255948_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJ31"/>
    <dbReference type="OMA" id="EQPWAIF"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="3">
        <location>
            <begin position="520"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="758"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1376" mass="150059" checksum="9D347597EAD9AEBC" modified="2012-11-28" version="1">MSNFGQAFQNAGFDPSILYQLPNNGGNVNPAALSGMTGGVDQSQQQQGMQGFNLSNAAISNALGGNTNNVGGAAAGGGGALPTNWLNSFNSLQSHASQQLDQRARQQQAMGQQQQNPGQTPNLMGSAPSQFDLAVRAGVTNAGGQTPNPAVLAQQIQHAQQQLQQQRFQQAQQQQVQQQIRPGVQPQQPMQQQNATQLQQNAAQKAAEALFNAKDVSGLPPQTINQYAALIQKGGMSTPEMRAAMQRLQQVQAAQQAANKNAAGGSGLGGVDPNNNNAPLMTTNPLQPQAQVPGLPQSAQTLTEAQRRELFANRIKQSGLTQAQLLALAQQQRAAQAQGQRLSAGSLAQLQQAGLFGLNGNQPLPPHLQQHLINQLKQSQMGNQNQQQQQPQQQQPGQPQQPQQPGQQQQPQQPQQPQQPQQQQPQQPQQQVPQQQTPQQQPQQLQQPPQPQQQQPQQQTPQQQPQQLQQQPQQVPNMQNQGMPNMGQSVPMANQLSQNAQQPGAGGVGGAGGPWNMQQTAPTQNFPPEEDWLRVLRSLHQRPDLQYPLVNGKPVNLYRLFAYVFAYGGYRKFDSQPIDKLWTTAAQAIGFLPSNQPGADPSTIARQISEVYHQFLSRLEELWMQNLQAGQRNQQQQQQQQQNPGVQQNAVRPQGLMPQQNPGQQSTPQQPPQQLPQQQQQPQQPQQPQQPQQQQQPQQQQQMNVPPNPQQPGQIRPNMTNGLTQEFMNAVAQNQGMTLTEEQQRIMRARVAHAQSMQQQAQQNQQNQQNQQNQQNQQQQNQQNQPTPQNQQNQPTPQNQQQPTPQNQQPTPQQNQPPQPNPHPVSFQEVVANLRHKEAQLEAAFLNTRKQTVQIPPEQQAEYRSVLESVVRLATEAKQRSPLFSVVAQTAEDRTRCHGLVQLTAICSAAVNKTKSNQPCLTLKELEGVRNRLKLVIDEASVHLQQAMTDPNIRKRMQSLTNHNQTEAMRAAAAAANQQNQAAQQAAQQQAQQQQQAQQQQQQQQQQAQQQQQQQMNAAAAIAASNNNAANNNAPASTSASANANTPQQAAHALSPEMLNNLIKRPLKQEDLKPPPLPKSRKGKVSESPKPAPADEKTPRTPAAATTPQAEASTPSTAAPKRPAKRKSSVAQTPKSAKRAKADEDAQSEKAPTPAAPTAPTPQNVESAPTPGSTSGATPAAAGFSGNAINVSRATHADYFAQQQKGAQQEREQNAAFFAQRQAVGAFDGDVNAALNMWTSAQMMPPQGPAPPPALGDGPGGVTLMAQTDDALADQSWHDFINEQNFDPDEPTPLLTRCRSLDTDPECSPRDGDILGRSPLTAMHAHAVGMHPGAFDPNDKFATRRIPLMSPSAQLYNGMLFVNTEVEHPGAMEPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WK70</accession>
    <name>K1WK70_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WK70"/>
    <dbReference type="STRING" id="1220162.K1WK70"/>
    <dbReference type="HOGENOM" id="CLU_756908_0_0_1"/>
    <dbReference type="InParanoid" id="K1WK70"/>
    <dbReference type="OMA" id="RENCSAF"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="366" mass="36610" checksum="DFE06D152A858F1D" modified="2012-11-28" version="1">MAQRMDNTCWAAGGKHIQADRQVCKWIRLDESASTPFPEDDFDDSEPPTASATPARGVTDTPRPMEDDEPTPAETPAVTGTPAVGETPETPALDTPAGGETPVTETPAEPATEIPTATETPAEPLTAAEPSPAPEPSVAPSEPAAVADVPSEPTADDVQGEKKEPSPAEGTPAEAAQTELVAAVEPAIVDAVMTETLIEEEKPAASELAATEAVSSAPVVVETALAESVPAAPATEPSAEPSAAQSTETPAEPTPPAAEVSSVPVTTEPDVQPAAVAPEEEKQADAPVSSEPAAEVATEASAEAAAPAEPSAAPSASAEAEVAAPETAAEPATAAGAEEPAPTAVETTAETSTEAPKEDEAMAVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKC4</accession>
    <name>K1WKC4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKC4"/>
    <dbReference type="FunCoup" id="K1WKC4">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WKC4"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002197_1_0_1"/>
    <dbReference type="InParanoid" id="K1WKC4"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="965"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1233" mass="134444" checksum="B4E3BB035A700E61" modified="2012-11-28" version="1">MVAEPNKRRVSYIIPPPEGETPLLNLPSFGTVASDDRYYPLLERKPTAPVTNGISNGTRGPLASRNPFLQSPPPPRVDPIQSQPPRPRHPRHRLGVSSLALDTSTVLSGCDSPGGILYTGGRDGLVASWELHVPHSKRRGRRYRPVGRGQRVRWERLGDGGEDWNEDDEDGDQDHGSFESSDDDDDELNSRIPYEDKWEIDRSAIARQPPSPTTFRQSVQTHTDWVNAMTLCNMNQTVITASSDRTIRAWSPHAEGEPAVPALIGYHTDYVRSLAFARHPGILFSGALDRDIAIWDIASPRPNEPVLKVRLSDKDDGCVGLEGEWGSIYALGVDPMGHTLAAGTPERVVRLWDPRAGDNSVTKLVGHTECVRSIVISDDGRYMLTGSSDTTVKLWSIGENRCLHTFNHHTSSVWALHSTHPNLERFYSGSRDGYLCAVDVEQCGDMSEGECVVLAREGDIDRPGDYESKTGDEAIRSIVAMDDEYVWTATSSSDVHRWRDVGRRVCRMDEDLDLDDPVYIAPDESQPLVNQPEVEPQPIIDNSPMRNRRFEGGESLNRVDSQDSRQVAFAPASVTAASPTAPSGIPSSIHGRLNHGHTSSIMSEASVLPPDETRNGIPYESLVCLGLPDSPYHFGFSGATHSQASINSANRARSPDDSPEAPFNEPRRGDARRAFEDRDVASEALPLRREADATIDGSPGLIRSLILNDRLHVLTLDTHGEVAIWHLIRGECLGRFSQADVAEALELERGVEDARMEIKLHPHEVLELVQRRIEGKNAVLPWCQVDTKVGQITVHLEGDRVFAAEILAEEMGVDERSLPKDINSINIGKVALSSLFRGLIKAEEAEVHSIASSSPQSHPSSLPSVSRSPVQPMSIAIPAGAPRHRARAMSSASSTGLTPAINIAGLATPAAVPAVRPEPTTPFGQSAPAASGWLAAKREGFGASPTTPISGSLAKSSETKDYFSLGRQASSGGGEPKSPAAVTSPPPKTKKTWFGKKKAAEPMAPLAEERKEVDSGPQLSDRDRAQLMFLDQLRSKQFHPPGPETPFLPLPASTNVIVSEQAHADGAYMVTYRSQVGGTERDLEPLEMNSPYWLLDFLFTNSIPDRVIPKIPIILLPEGLSVSSGRGLKVQASRTARVRGVIEHLAGILAKEEEQAPGTVPRALGALVRDRSSSTASNMSGIARPRPEELMELVCGEHVALPEMKVGALKQFYWRGGPDMVLHYRPRGVPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMH8</accession>
    <name>K1WMH8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">A1Q2_03385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMH8"/>
    <dbReference type="FunCoup" id="K1WMH8">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMH8"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="InParanoid" id="K1WMH8"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="383"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD02329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="800" mass="89327" checksum="7A2B4ED8C0A1AD73" modified="2012-11-28" version="1">MSATVGVLPVASIPVNYEEETQKITDFLTRFVAEPRRGRAIPEDDDDGAEESSDEEIEDFASLDLEDEGEGEGRSKAKYMRIMRKVANRQTTEVVVDLNDLQQFDQDRSLLTNIMNNTRRYVQLFAEVLDQLKPQPDHELDYTADVLDLIMQQRQNLNAETAEQAQEQQVDVAASFPPELMRRFNVYFRPPKNKKEVLAVRSVGAHHIGHLITVRGIVTRVSEVKPLLLVNAYTCESCGNEIFQEVAQKQFTPLATCPSDTCKTNQTNGRLYMQTRASRFQPFQEVKIQEMADQVPVGHIPRSMTVHMYGALTRSVNPGDVVNISGIFLPTPYTGFRAMRAGLLQDTFLEAMHVHQLKKQYSAMEITPEIQAAIDELKEDPNLYSRLANSIAPEIYGHEDVKKALLLLLVGGVTKTVGDGMKIRGDINVCLMGDPGVAKSQLLKYITKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLYGRYNPKVSPVENINLPAALLSRFDILFLILDTPSRDDDERLAQHVTYVHMHSAAPELDFDAVEPTLMRHFIAECRKVRPTVPAAMSEYIVSSYVQMRKQQKEDEAEDKNYTYVSARTLLGVLRLAQALARLRMDTTVNQTDVDEALRLMDVSKASLYEHQTRSGEDHSDTSKIFRIIKDMASGRGAAARRRAAGEETDSDDDGSLQDMSVVELRNRVIAKGFTENQFIDTLTEYENMGVLVRSTNGQRVRFVNADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNA4</accession>
    <name>K1WNA4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNA4"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="InParanoid" id="K1WNA4"/>
    <dbReference type="OMA" id="AWWLWAT"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51343" checksum="55172054D4FCD917" modified="2012-11-28" version="1">MSEKERSKTSLHQGLDHVESAHSGDDTAANIPTQHKSKRSFWRSPLCAAWILGVCNFCAPGLWGAMNSLGAGGTASPWIINAANALTFCLMIITAFLASTIMDLVGVNFALFLGGIGFAPYCAGLYCNVVYGTEWFVLLGAAFCGLSAGLFWAIEAAVAMSYPEQFRMGKFLGIWLSFRVAGQIVGGAINLGMNADGDYAGAINPNVYIVFIVLTSLGPFSIALTSKIAFLLPRPHQIRRLDGVEPKLYTHTPILTNIKETLRVLLTKEYLLIIPLIAQAVFPESYTNTYMASFFSVRVRALGSFVAAWACIIVGNIVGFFLDRHNVPLKTRARAGFIFMMTTRGAWWIWSTVLMAHWPTPDTIDWTNSKYFGRTFALYVFLGASFQTHYLYLYFLVKHSVKSSSDSSRAAGLLRAVESAAQAVAYGTSSVASFAHLGSSCLNFALWGVAIVPAWLVVRRIGIDLNGPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQ87</accession>
    <name>K1WQ87_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000264">
        <property type="protein sequence ID" value="EKD03194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQ87"/>
    <dbReference type="HOGENOM" id="CLU_1074378_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQ87"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="259" mass="29445" checksum="03470454FC9C5293" modified="2012-11-28" version="1">MSGSTSIPSWADLKDNVPKLTSTTDFERWEHAVRVYCLGKDVLEHIIDHTLDPYRVAPMPHTNVDAYPEGYIAGVSSPKGRDIAAHIIREIVIDELDEDATNAQINAAVQQWGANRTLTDDLLTKWSVWARRERLARTILLSTITEDVVIDYERLPTARFIFSAVESRFKTLNPERASLLQRELHSQYLPRGATADDAVTFYEKFVHIYAQLSRLQVAVNDEDKVAIILGALPTEWAVLLRSQWSTETSKTWSLLWVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQM3</accession>
    <name>K1WQM3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prefoldin subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQM3"/>
    <dbReference type="FunCoup" id="K1WQM3">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQM3"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113004_2_0_1"/>
    <dbReference type="InParanoid" id="K1WQM3"/>
    <dbReference type="OMA" id="DRYERKM"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="212" mass="23447" checksum="E749928A3C39A907" modified="2012-11-28" version="1">MATTASSSAAGAASGSKQLDPQQIQVQFQRYRTELQSLAQKIGELESEMEEHARSKDWRSGGLPQMAFLHFWMATLTPTAHPNLFSGRSSLRQANSSLVLSTLKPLVTSDPERKCFRLIGGVLVQRTVKDVVPALETNYAGIKEVLETLVKTYKGKEEEFASFQREHKIVPLRILHTGSGSLPAVGLEWNSALEGEALKIEQRANEQMPGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1WW18</accession>
    <name>K1WW18_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD04999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WW18"/>
    <dbReference type="HOGENOM" id="CLU_1636613_0_0_1"/>
    <dbReference type="InParanoid" id="K1WW18"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="162" mass="17992" checksum="CCA1299AC1AB9559" modified="2012-11-28" version="1">MGASSLWQRACLSRSALTTIQLLRNIDDVSLTVADVDIPAATAHVVHGHSSTIETHPNHVRNSNSDISNTSSPTALQIKRCVDQYRQPVTTLPPHMKSEAAGPYVLARQIQGWRIRDMWSTLYWQVLLSAVWIEYQSDGRLQYAPHCRLQGITGFAASSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWA7</accession>
    <name>K1WWA7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWA7"/>
    <dbReference type="HOGENOM" id="CLU_349908_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWA7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853184" evidence="3">
        <location>
            <begin position="19"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="803" mass="85040" checksum="F05E08992F0C43C7" modified="2012-11-28" version="1">MRLRLPVWLAAAAAVAVAQEQREHNYPAILTPGDGVLLFSPASAASAWMLSNNSDTNSSAVASTSQFVASANATNASASFAFYGSSFEVLGSGNGELVVSVLGFTDAERDPRRSPDWDSPHHDANASHANRTREISTQRYAFNATAGGVLYSDNSTSAEWKNVTVQLASGAVAIEQVQVTHRVNVSANRAEEAPLLTVPAVWWGNGSLNGGREIQFYGPWESKNITSDAEPRFTSSLTGSGSLSLRTPLNASFVRLNGHFDQNCAPYNVGVTAVGGRVPNARYRPLCTGKDGVVYEAALDPTLQYNVVLRSAAEDGQVFGFTSAQFLSSTLDLPRYTVDNVTENTDEDESDGVAVTQQNKGNNHVGAIVGGVVGGGVGLALLGLLLWCCCRRRQKSRPSSIVTTEEGHEKPYKRNVPYNDGAVSPPTVPAVGYGPCHGGWWSRLSRKPTIAEKRGRLSSAPPQLSPIKTGTVTRLNGIASLGASTATGSLAAGPSEALVEPSPYPDPGPASSKRSKFSATSWSLLSLGSRGSKSRDVLSVRDPKKEQRASKQTALTHLSWSSWDILDMAPPQSAKRAAFSKFSNSSWSFITPPNAPGLGSHAGSVPPSPRVPGTPSTPDSPVPPPPPLSPLPAFNPPAFDAYANRSESEISTLPKNSFDASRSTFARTSLDSGQGPALAMLRRDDTGRPSTEAASSFSNLSSFNISRTSFKINPLRMPPSAGGPGPSALGRSRSPRSPTSPTRPHPPQGPRAPGNNFMRSVSSRIALAGFSKSKANLPDVRLSEENGNTLERLEKEIKRASQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXT8</accession>
    <name>K1WXT8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXT8"/>
    <dbReference type="FunCoup" id="K1WXT8">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WXT8"/>
    <dbReference type="eggNOG" id="KOG2135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017928_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXT8"/>
    <dbReference type="OMA" id="PSAKCAF"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="571" mass="61625" checksum="A4EA487EBF17D59B" modified="2012-11-28" version="1">MSFNEACESPDFKKWLVVTLEPLEAETLSLSQLTARCDADPDVLADYIIALLKHDSNQDEASWKTYMKTELEEFLGAQTEPFVNACFDVIQTKAYMPGAAPAAPAEAPMAAEPQPGPSRDTEMTDVSNGLPQPPQQQQQRRPRCRDYHGALSVSCSYEHSDDVIIPTPEMMFAQMAPMMGMQPGQFGGRGGRGGRGGRGRGRGGMGMPFFPGGPNMHAAMPPPDFMGTSRPPSDRNGTTLLISDIPPQHLTMGALTEYFGQFGDVTNVAIEGKSKRALVSFATNREAYQAWKSDEAVFGNRHVKVLWHRPRAGHGEAGQKMLEQSAKLIENMKKLEQGGVNPQGDVVAKLEGPESRLRKTLVELEAKERRGKRETLIAEQKVLFARAASASQEDKVAIPGPDQGDREGDGRAGEAEPAACRADAKGQAGRRARRARHGDGPVGPGRAAASERSAERTPRKGEHDGHSRNAIAGEALGSEQGQQAIKEWYESTGGSLAPTDDGVLVTYPSREMAEKALALGTKDIPNLSAPINVQWHAVPSNGHGQAHEGDGEVEMGGGEDGEVHEQRDRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY40</accession>
    <name>K1WY40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000066">
        <property type="protein sequence ID" value="EKD05579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WY40"/>
    <dbReference type="STRING" id="1220162.K1WY40"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485007_0_0_1"/>
    <dbReference type="InParanoid" id="K1WY40"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="562" mass="60415" checksum="446C1ED41BA049C0" modified="2012-11-28" version="1">MSPLPYNTPVMTRLWIDLEATHETCGSTGESVTASRDGSSVPSSRNTPQPATGAPAGHALSIFNDKTSNEVAAEVQTIVGPSAGRVLRERERNTTPSSSRGRDGLERSGVSASGRGRRVGGSARVANKGTQQQNNSGKGKGKAAPASENFVNQDFCSVCRGIGRFLCCDGCPRSFHFMCLEPPLRIDELPKEEVWYCRKCKADRAGTKGVDVIRAKDKPITTIFKTMAAKLDQDNPQQFRLPQEIRQYFNGVGTGAKGEYLDTESARNKYDRRVRGEAKERDPARGHGHQPAMAGHDINYLAVSGVLSMLGRAGDKPHPPTNILGDFAGGGAVLFQGILLALLSRGVSGKGQVVEANMVDGASYLSSMPRMGQKTPLGAGPRGTNMLDGGCPFYDTYETRDGKYVAVGSLEPQFFREMIKGTGLDPSWAKRQQNLDEWDTLRQQMTEAFKSKTRAEWEKIFDGTDACVTPVLEYSELEGKPEGDQRPIVTLRNTPLLAVTPGANGDPAKGQGPGVKGAGYSGNSLTPGEGGPAAINSWLGWDKGTQWEEVNGGYQVKQGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WYH3</accession>
    <name>K1WYH3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000034">
        <property type="protein sequence ID" value="EKD05669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WYH3"/>
    <dbReference type="eggNOG" id="ENOG502RBDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1769398_0_0_1"/>
    <dbReference type="InParanoid" id="K1WYH3"/>
    <dbReference type="OMA" id="MMVSCLE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="147" mass="14541" checksum="3D5863806E682F0E" modified="2012-11-28" version="1">MGNCFSSKKQGQVLGSGPPSAGASAGASAPSVGGTPVSPSGNTIGGSGNPDDPRAAALRAAEARAQAAGNRGVSPTNAKAGQLSQKLAMERRTSSTANVKGNPNERMMVSCLECEIGADIRMPASGTSLSGGFVLISLVLFGKAPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1I3</accession>
    <name>K1V1I3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1I3"/>
    <dbReference type="STRING" id="1220162.K1V1I3"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408433_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1I3"/>
    <dbReference type="OMA" id="CAYGNNC"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="2" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="661" mass="64143" checksum="98D2F1DD76590A88" modified="2012-11-28" version="1">MRRLRPGNQGGRFGSISSSNATPLGTRAPSHAATRYQFNEDSVKHELGAERPLWVISCFGASKYEPNVLQGDMSPEELRWKAVQALKTGGGAVDQYVAEENKLVGEAKSKLDEALSNIPQVVQTAQRLHDLRFKNGAVPGSDRPADFNEDVALAAAKSGGPAPVASGSAFGQSSFGSSNNTAGSAFGKSSFGSTTAGSTFGQSAFGQKGASNGGSAFGQSSFGAKPTTGGAAFGQSAFGTGSSSGAFGSSSTAGSAFGSNTASTGTTGGSAFGQSSFGQKPAGSAFGQSAFGSTATSTPATGAPATAGSAFGQSAFGAKPAGSSAFGQSSFGQSSTTTSTTAPPAGSAFGQSAFGAKPSAFGSTSSTTTPTQGSAFGQSAFGQNSAPATTSAFGTGASATPATTAATGGSAFGKAGFGAFSSGGTGAFGQQSAPATGSAFGQTSTPAAGSAFGNTSITSAPAATSAFGKTTAPATGSAFGQTSTPATGSAFGQTSTPGTGSAFGQSAFGNPAAPATGSAFGQTSTPASGSAFGQSSTPTAGSAFGQTSTPASGSAFGSTSAFGKPATSAFSAFSASSTPAAPASSAFSKGGGFGQPSTNAFGKATFGADVEVPDGWSYEDPWSCFLPKPEELEEEVRKAFEAVQFQPDKIPLLPPPVALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2H6</accession>
    <name>K1V2H6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP-dependent permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_07650</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2H6"/>
    <dbReference type="STRING" id="1220162.K1V2H6"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_1_1"/>
    <dbReference type="InParanoid" id="K1V2H6"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851815" evidence="14">
        <location>
            <begin position="17"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="395"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="660"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC98104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="839" mass="90506" checksum="9080C32B676C4EA9" modified="2012-11-28" version="1">MRVTAALLLLAGPALAGSYRPPPSLELLDLRGQVSFNPTPVNASLIPPRNPGGRPKDCPPCFNLQVSCGLWRTGLSDTLTAMSGTPAPTASCASARKVGAVSTAKNDKACKGFKLRNPVDDMLFGQDKHKDKDGDKDGDGGDDEIPDMVCYQGGVAIERNFQMCDVTNRKIRDTIPDNKPPQVTFSCEAGGHHANGSDIMSLYDPTAIGNEKGTCGFQFWVDRIESFYCKLTECTWELDQTVSANETHYKCENIECACVPGRFLCGENGSVNIDDFLTEEVRGPGSFNCISGKGCTFEEPAMNKLINDIFGDSSITLDCESGECVHYSQVPGYVPPAQPDNTKFIALMGALSVSLFLAAFFWYMGRNNDASGFSGIKLPEDEAARLMAEHVPATLHFSNISYTLPSGKHILEHVTGTCRPGEVLAIMGASGAGKSTLLDILARKSKTGKVSGEMYVNGRTIDNSTFRRIEGFVDQEDTLLPTLTVYETVLFSALLRLPREMSYEAKVYRTLETMNELGILGIRDARIGESGKRSISGGEKRRVSIACELVTGPSILFLDEPTSGLDSYNAYNVIDALKTLAKQYNRTVIFTIHQPQSNIVALFDRLLILAKGQLVFSGKQSNAQAHFESNGYPCPPGYNIADYVIDVTVDAAGDARKMTGGNGLPTAHSGGNGGIQDPEAGFSRRAAQSSSTSTDDEASVSQSGIKMKAAKLLGAFTSTSGTTTPAESVTPIPEALASLVLACRGSDDMKIVEAEVHRIETGETPNGGEQRDIAEETAMLKGYDKAGFWTQFKVLSGRAFRNLYRNPMLMAAHYAVAICAGFLCGFFFYHVTNDIPGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2X3</accession>
    <name>K1V2X3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2X3"/>
    <dbReference type="STRING" id="1220162.K1V2X3"/>
    <dbReference type="eggNOG" id="ENOG502RB8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602946_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2X3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="454" mass="50888" checksum="6A53F3912FE719B9" modified="2012-11-28" version="1">MLRSKAPESVVSKARIPYGFRADAAQRPILRPTPAPYWNGKRQSPACFSTLPDPMCSRLPHTLGYRQQDQHCPRDRFGALAPPARGSTLSDHAALSINILISRHPSLPLRRGHGGMGVPKPRQVRFATLLVLLLLALLLVVNDCRSGWGWAWRTRDRLAALIFLRPTEPGARSQLLQHLLIAQPPAAFRTPSLKEAPLLALYVFSTSNVAGYMRRQLIRRQSPLKRLPEEYQPLVQLRFVIGQPVTPTKLLWTLPEDLSAEQDEHEDLVFIDEDVDGGKSLAWMRAVGQGEPAQWVFKAGDDLYFTGSLYGFSWPVVAAVGAARLTEDEVRLPRQEDVRTGDVMLSLPSAPGSDLKAEFPCLPSCSDEALDKLAQDQVNRHDARVGTNPRTGLRYVNVLSRIGVWHDGVWWPAGRKALAWQGLEKDTDFIAASNDARTDWRPPRWIRKRLNLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5G2</accession>
    <name>K1V5G2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5G2"/>
    <dbReference type="STRING" id="1220162.K1V5G2"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="K1V5G2"/>
    <dbReference type="OMA" id="TWHAWQK"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G09140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="23588" checksum="2EEFE58C6D45C75D" modified="2012-11-28" version="1">MSSSGQQRVAIVTGAGSGFGAGIAKRFQKDNVAVIVADIRGDWENVVKVAQDTYGGLNYVINNAGATYKSKPVLTTTEADFDLCIDVNLKSIFHSVHVAVPVLQKTTAAGQPAAVINIASTAGIMGRPGLTWYCGSKAAVISCTKNLSIEFGKQQIRFNAICPVFGNTGLKSAFLGETTEDQMLASIPLGRISQPSDIANATVFLCSDEASFLTGVALPVDGGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5Y5</accession>
    <name>K1V5Y5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5Y5"/>
    <dbReference type="STRING" id="1220162.K1V5Y5"/>
    <dbReference type="HOGENOM" id="CLU_090088_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5Y5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28372" checksum="C5D1843570BEF8C8" modified="2012-11-28" version="1">MPPSKLDPASQKPSRAPSPIRDNWDEGDFLLVSSDEREFRVDSNVLFWASSVFQDAGSGPVNSPREIRFCDPDFEHAGVLCSFLRLCVRGTFVNGSFNWSECEAGVALIAFLRKYDCVRPLRVLKLCISEALFERRLYPLHAFVLGANMDDVSLCCTAFRERVQFVSPTQLDDGLALVLSPAQALMDGAWPYPVWQHTPLPYIYAATKAANVFEKEPHVPYHGITRSGTPIFRKKDLADEFEKAIRKVKATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6S6</accession>
    <name>K1V6S6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6S6"/>
    <dbReference type="STRING" id="1220162.K1V6S6"/>
    <dbReference type="eggNOG" id="ENOG502S73V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_2_0_1"/>
    <dbReference type="InParanoid" id="K1V6S6"/>
    <dbReference type="OMA" id="QMAGRNI"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="52"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="157" mass="17499" checksum="532A165480F38E4A" modified="2012-11-28" version="1">MRLPQHAHDLSAQLGPLAPERRWIIAGGAVLTLLFLGYFMFGNESSVAAMSVFHIVAFKLARPSDLPDLTARFLQLQASCQLDGRPYIRSLRGGKQTSPEKLDGGMQVVFLAEFANQQELEYYVFRDPVHEAFKKGLEDLGVESVTVLDFTDGSWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8C4</accession>
    <name>K1V8C4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4187 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8C4"/>
    <dbReference type="STRING" id="1220162.K1V8C4"/>
    <dbReference type="eggNOG" id="KOG1994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660588_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8C4"/>
    <dbReference type="OMA" id="MRMMLAM"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4187" evidence="2">
        <location>
            <begin position="414"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="470" mass="51627" checksum="F6DDD7EB3B6488D0" modified="2012-11-28" version="1">MSDSEDDFMSDKFLVDAPSASEQTYSARRAAAQRKSAAKVAAHTAQQRPLREIEAERRKAGLARNLLADSDDEDEDEGEGRRKLAPKPTRTQGQSKAVGLMKAMGAAAQRKSAAKVAAHTAQQRPLREIEAERRKAGLARNLLADSDDEDEDEGEGRRKLAPKPTRTQGQSKAVGLMKAMGWTPGEALGRRRSASPPSKSRATEPSDPTNASSSSGPCGESGARGRERAEPIRISMWAGRRGLAARTPSPPPLHKKESNLESLAADVERFRGRRGAEEEQRANERKAHKARELLVEFDTEKGVVFHPLHADPLNPGALPTPLRARLWPDATPPPSPPLDPATTRADPTAEPLKFRNEAERVRAQMRRDMLTTLGPNADDEDIRFSISLPERDEEKEALKQEAADEKAMDWDEVVSGTKRVLAMNAADNLAFLVSQLRNEHLFCFWCASKYASFEEMDAPGGCPGEEEDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8Z1</accession>
    <name>K1V8Z1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-end rule aminoacyl transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8Z1"/>
    <dbReference type="FunCoup" id="K1V8Z1">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8Z1"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020349_2_1_1"/>
    <dbReference type="InParanoid" id="K1V8Z1"/>
    <dbReference type="OMA" id="GYWIANC"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="405" mass="44980" checksum="66103957BF75225F" modified="2012-11-28" version="1">MARTCCPQYTIRLDTSAFKPNRHQRSALNRWNRYLETGLKPGEEAADDPMSDKPTAGKKGKGKGKAAPFDLDAELQAFVGNKGKHKFELDFRPAKATTETFELYRRYQMAVHHDPPHKATRRGFENFLCDSPLGCIEYTGDSEGLPKTYGSYHLLYRIDGDLVGISVIDVLPHCVSSVYFIWDPDWAWAALGKLSALYELGLVRRMAVAGAPGMRWLYMGEAAFRNETKLTAGYWIANCQKMAYKGEYAPSFLLDSGTYDWHSLTPKLSAYLASHRGYTPFSEVEGMDDGLVAEWKAAAKPLPTTSAEAAAHEEEEDDDDEADWPSPPPPGFLDPDKLPKSVVNGAMVAMKQRGKLFALPFKQFGEFLTPAGRRCVPELLAAMGPDMFAMEGKGEEGTKAMLCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9E4</accession>
    <name>K1V9E4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9E4"/>
    <dbReference type="HOGENOM" id="CLU_593374_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9E4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="461" mass="49735" checksum="70B25B85BE3E5146" modified="2012-11-28" version="1">MNGGDSGWSRDEVMSQSRPQSRNESGPHDDARSISQSIGLTSGISIRREGQGPTRRKGAEPPERRNGADSAKEDRADRPPWPVWAWSRTSRRNKATSAFTEELCLDQGVLDEANISGLPRTCHAQRGVQRGWGNRTEEPIASGRHGTEKTGKGHEGCEGQEREKDKGQEVGGGGWAAWAGWERRGDGAGGFGKERFKDQRGGPGTEQGAYSVDQPFRHPSRLLTEPESQPCAAPGDVPNHPANHADSGHPRAASPHALPDEGHPARSTTNTPPSPSSIASHFTSSSSCSPASDMPGGRQSPPADPPERVSHIAVDSDFFAPPPPAYSTQPPLPPLASTTTTSSSFDTKGTAATTSSLRLDSKLSSISEIEKGVYQSLSKHDWIDNEQNSTTNSSEHSIRSVIHKNVLNPILTFLSPKFKDKEIERKFRREVSASPPDRDLLSSVSITISGIRIYDVSDIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9K8</accession>
    <name>K1V9K8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9K8"/>
    <dbReference type="HOGENOM" id="CLU_2741846_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9K8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012090621" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="71" mass="7491" checksum="76536C9FA9517AE9" modified="2012-11-28" version="1">MKLSILLTLLPLALAHGGGHGGRPRDCPTKTVEVCAEETKAKWGKPIFVTTTVADTQCTATTVTEVVCILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA75</accession>
    <name>K1VA75_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA75"/>
    <dbReference type="HOGENOM" id="CLU_2122798_0_0_1"/>
    <dbReference type="InParanoid" id="K1VA75"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="114" mass="12632" checksum="56C14030AB6271FE" modified="2012-11-28" version="1">MCDLTPLPLHSMSASEKRGQHDQHLRILEKRIEVPGIVLTEADDDYDVSCSPTPTGRKQVVLLNPCTVYGPRVRPTAPTARSLVILILVLLAAYHLWTHLDLLHVQVPQAAVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAC0</accession>
    <name>K1VAC0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000329">
        <property type="protein sequence ID" value="EKD00980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAC0"/>
    <dbReference type="STRING" id="1220162.K1VAC0"/>
    <dbReference type="eggNOG" id="KOG0540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_1"/>
    <dbReference type="InParanoid" id="K1VAC0"/>
    <dbReference type="OMA" id="GATTHCE"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="321"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="585" mass="62467" checksum="260C5CA8FCA80BBE" modified="2012-11-28" version="1">MMLRARTRVAPTVARAGNLNLARTLIAQPPTLPNNAPPSPLPTKLKPNDPETKEAKANMTNLVENLKALRAKAREGGGKKTLEKWKAKGQGKLSARERVQALLDPDSAFLELSPLAAHEVYPDDLPGAGIITGIGTVSGTRCMIIANDPTVKGGAYYPLTVKKHLRAQQVALENRLPCVYLVESGGAALPYQSNVFPDHDHFGRIFYNMARMSGLGIPQISVTHGISVAGGAYMPAMSDVVIIVKNQGRIFLAGPPLVKAATGEVVDDETLGGGDMHTSVSGVADYLAQNDAHAIRLAREAVLDLGKATVPSAKAPRETREPAYPAEELNSIVPADSRKSFDMKEVIARITDGSEFREFKKEYGKTVITGFAEIHGHTVGIVANNGVLLSPSALKATHFIELCNQRGIPLVFLVNVSGYMVGQAAERGGIAKDGAKMVRAVARAKVPKFTVVVNGSYGAGNYGMCGRAYSPRFLFMWPNAKVCVMGPDQLSSVMQTVSGNRNAADAEKKFAELRARIEKESEALYSTARLWDDGIIQPSDTRDVLGLALEVAADEKASRPQGGNGGSRGEIGADGDSGDWGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAU8</accession>
    <name>K1VAU8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAU8"/>
    <dbReference type="STRING" id="1220162.K1VAU8"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019520_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAU8"/>
    <dbReference type="OMA" id="WVEALCR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="435"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="750" mass="81384" checksum="22B386583DDF41E6" modified="2012-11-28" version="1">MPFRARLNPSTLARRVAAVRPVRPLPGVSGAPSLAATSASASAGPGPRTLELRSNRTYKTSAPAQAFSFFRRKPAPIKPADAVMATLGPGLSDPLAAAYDNLIKWIEYDGNTRRLTGEEMERLMAAISGRRSAAAAELMQRLWNDLALHGLQPEDRYLRQLIYSLARNGKADEALALLLDGHAAAIEAREWIELVRCAAKSGNTDAVLSLAENGIKDERLYAALLNALNGKDGVDSAQLQALLDRMERNGVKPGLWTESALVPIYIMLGDVASAKSMADAWPSVEDEMLRSSLLSAKCEVEIARRDVPAAVEVIRTMAGTDDEVPPRASSFVINAYRASPTVRDTVDAVHRFRGETGVRLSKEGWKRLILGMDVDNALALLEEARLEAAVLDEPLAKALIGQLCDAGRIDDAMGLYDELVIASDADPTNESRQPSMDIFRRLLAACAREGDTDTALSVLAAIKEKGFVLRTPKLGEQLTALIAAAPDHVIALDLYKAFRAVSGRWSAATFSFAISAFVRLRTKSSAVPPPDFVIEMMHDMRKAGYQPGAEILTSVLASYASLAKRIAKLPPTAETEFKRSALLSATRDVRTLTSLDPLIVVDLNLLNTLMNALSCCGASAEALRVWDEILPRLSSEDKRAGEVSVAIVIDACSYGGQFARAKKIWGWATRHGLNSGLGARSAWIECLCRYGKYEDAIAAIKDFSDPPADKDLAAIVLKYGFRSDSPQVVFDALQEAFPDWWPDLSKLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAW0</accession>
    <name>K1VAW0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAW0"/>
    <dbReference type="STRING" id="1220162.K1VAW0"/>
    <dbReference type="HOGENOM" id="CLU_413992_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAW0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="71196" checksum="3B5F360764073125" modified="2012-11-28" version="1">MCDFDGASKAAFDGEPFTLDSETGYRTSAGRSSGASGCWFVGTGVTIEGRGIWKPNTPEPHDPPDPVHAFLYQTNQEFRTVLDTENFFNVSADNTALLDTRGRELRSYELRFTITPDSQLEFHNMTVDVPVRTQAPNRDSLEKQAVYVPVIQDGSVNPTMSLGFTTKSDQFRDMWAKRTNSTTAPSPYDSTVPRFVQPGGAQQSASQAAQSPQTPDQLQESTTAGENQAPQTSEQAQPNDSSNQPNRSEQPASSSTQAATSVAQSQSSRQGSPAAEQQPTQNRQHQTPKSEGQQTPQSSAGQSPSRSAAQAASSSHAPPQADKDGMAIDWTQAGRRHLPHSPHTKRLDIPHEIVDNALMLKNGTELSYKVPISTTLIRVYGPVGMNETAYGSQCYADLDPVPSCNYTLSDLVATNATAANKTAPPTIVQSSDLPIGTGARSSSASSGGNKTGMIVGVVVGVVGGLILLALLAWFCLRRRKSNEPDDIDPYLISEKDLYRNASWAPEGNDHPPPAPVSSGGENRPRGPRVVQEEDADDVVEYLPPRYRERTLPTTPEPASTPPLSTPDLGSSHENATFLPVPEGAGGPTLKEEYMKNMGIAPGALESPSDKRALTHSSSESEQGTPLLKRAYGRLFGSGPPSEAGPSKTKDWKDDVKDREGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAY3</accession>
    <name>K1VAY3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC98000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAY3"/>
    <dbReference type="STRING" id="1220162.K1VAY3"/>
    <dbReference type="HOGENOM" id="CLU_746368_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAY3"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="371" mass="41372" checksum="3BC13D2CF76643AF" modified="2012-11-28" version="1">MRRPQPSRAPSHCPRASWSTLAPELQLHVLSFLPYPELVTLSAVSPSVRSLVLTPALHRTLRVELPVRRPGLLLRMLPHVRHLTIRQRTQFSFRFLLPSGPSSPSSDSSDSRDEMRDSEGSREGDMEIGRIWGGLGRTGRQAPSASLATHQEVVRYISKCEALEVLDMSGVRLAWSGVWPLLKPPLRQLTARGCGICAPTLPSSMEVFDAAFNSIVCLDTLGAERLRRVDLAWNNCLTFEDLAMISSRELEWVNLRGIDAITREDVRRLERRWNGLKDGAGIELDTEHRGRGREVTPPPGLISPPHTPDSSMDTDTEPKTPPPQQRPWMPPSPQSPPSPVRIMHTALLESDDEQGYRQFIHQVTSGTVVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC12</accession>
    <name>K1VC12_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC12"/>
    <dbReference type="STRING" id="1220162.K1VC12"/>
    <dbReference type="eggNOG" id="KOG3904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC12"/>
    <dbReference type="OMA" id="IIMFPPQ"/>
    <dbReference type="OrthoDB" id="2592539at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="382" mass="41327" checksum="5F9A650FA6D9BB0B" modified="2012-11-28" version="1">MLSLFAAVRRARPPPTIIAMSRPNSTAPPAAKKVPMVPKPSSSIMVLSPTNQLLLLHRVQTSTSFPSAHVFPGGNLSKFHEAVPAEDAQDRHRDSEAYRLGAIRETFEEAGILLAKKKGGNGNGDLVELSPGEVEEARKKIHGNKVRFGDWVESVGGTPDVDGLIPFTRWVTPPNVPKRFTTQMYVYMLPLGSSIAAERDASTVVHTPTHDGGIEHTAAAFDDVSDWLARQARGEIILFPPQLYLLTLLGQFLTGPGDYAAQREALLDFLKKTPTGPGGHPTASIPWGEKVISPVGLGIKRADGRNVLSLEGPGKEVKTQDPTRAGDHSRVVLVKPTKRGPSEVEIIWRSELGDEANSAKVDYEVVVSKHPSRDPKPVAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDG9</accession>
    <name>K1VDG9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDG9"/>
    <dbReference type="STRING" id="1220162.K1VDG9"/>
    <dbReference type="eggNOG" id="ENOG502RXWW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_1_1"/>
    <dbReference type="InParanoid" id="K1VDG9"/>
    <dbReference type="OMA" id="IMADNFA"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01014">
        <property type="entry name" value="nicotinamidase_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF15">
        <property type="entry name" value="BLR5631 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="195" mass="20830" checksum="1F2F9625880F67CB" modified="2012-11-28" version="1">MSEAKSFRQLAGVPPSTASTKDSVLVIIDAQNEYAQGALKIKNVEASRKNIKDLLEKYRKDGGQVIHVVHQVPEGTPVFTPGTELAEEFAELKPTGNEAVVKKIHPGSFAETNLDSLLQKGGIKRLVLVGYMSHVCVSTTARQAAQRGYDVLVVEDAIGDRDVPGASAEQLVQTVCAELGDAFGTIIKTAEVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF17</accession>
    <name>K1VF17_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF17"/>
    <dbReference type="STRING" id="1220162.K1VF17"/>
    <dbReference type="eggNOG" id="ENOG502SBV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087987_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF17"/>
    <dbReference type="OMA" id="AGHKNGA"/>
    <dbReference type="OrthoDB" id="2562681at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="162" mass="17923" checksum="93967140F981D7C6" modified="2012-11-28" version="1">MFHAHTTTSTQQRRTSPAAIMRDKHSRNGQVKGEHDRKMGAGAHNWGSLNHEETNIYQGNLDAEQEGMFDADNMDMGDASVSPQNSVSSVDSEPRPTGRRMSAVSDEDRERATRYREGGYKKGEPTLIEIARSAVGVQDPNAEDKEMLSTSPLRSKAGFSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFD5</accession>
    <name>K1VFD5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFD5"/>
    <dbReference type="STRING" id="1220162.K1VFD5"/>
    <dbReference type="eggNOG" id="ENOG502SEG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353430_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFD5"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="88011" checksum="8FC29A858FF12DF4" modified="2012-11-28" version="1">MSSSDEVREALIDMGVDPAKSHAASTMFGSVDAAINWVFGEGENPPAHAPPPPDYVTAPQPRKLRQWLCPANMTASSPANDRPAFGSNNPFAQQMGQLPAIPPPPPRRPDDDTRHVRASAPPPSPGVEQPDPLDGVPFFGPTNKDDPDNKLAVALPNAASNPNKEEEDFQRAIQESMMTASFHSTGSAAAEELPPAGEREDGHTVQMIQALAAIPQLRQVLAAIDWKTDDPSGELRKTEGHELEIIQELFKLQDTEKVTYEVIDPALDLFQPNYTNPNTSTVYANITGEWLPGLLKVLGQVGRNREQLIDFKTDVRLVATSLHINPDEPHPYVMFERGFNQPTNLHAALSSLIWGTSPGGGGGEGVEALGDVQFVHLHRSPGFPAPQWELDETIVLDRYLHHNRSWVTRVRAEQNFAEAELARLREKVESLSNYKVGVAFRTFADEPGEQHLRCYSNPFLGPGAEGVKSGAESEGKLSSSTAKLTAQLEKIAEKLNEKTTRLQEEIKEKEKQTSGALFETDDPEKTQHRHLYSYIKEGDQWWKVEAVEATKEISSDSTGQFTDGGPYLLIYSRDGLRPAAPPRSPEATRNVGVWGGMEGPGVHPADWSSSNLIDIDEDSECRQTPLEPEHETLKDDLLAPGTTITAVPVRSRRNTMDSEALSRETTREERREGDKRPSTISYAPPSPVAPSRQATHDSAVLSPPSRKSSLSGGVLSPSARKATLSPSASRKSTLESTRSPSRKASGREGTPGRKMSTSGDTSAGVLSPSRKNTHDGIRSPSRRSTTDTDATARDKKREPDGDLIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGH9</accession>
    <name>K1VGH9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000262">
        <property type="protein sequence ID" value="EKD03205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGH9"/>
    <dbReference type="STRING" id="1220162.K1VGH9"/>
    <dbReference type="eggNOG" id="KOG4573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276077_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGH9"/>
    <dbReference type="OMA" id="FHQVGPT"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="630"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="688"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="873"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="958" mass="100316" checksum="82E5EB8DE28B1960" modified="2012-11-28" version="1">MSRPPAPDSASSSVMSSGPGPLGGLGGGGSAAYGSSSSNTPSRADQITYRFYIKTVSVLVDGRVTHFGKGERKKDRWFNLTVPDTDVHKADLTIYRQISSYTEVPPLMIAFILDTTDIPAGQGIIWNPRPAGDGSGASVRVPIDVGKRKGIVLEQWTFKCSRGRNLQGVTEGKTSINLHATQPTPMTMTSEAPFNESTRTIAHSNRAPGYAVADLTERQHAAISTSDMAPPTAYRVGIVHFRALYSFIRLLPAYRLFRRLRRQNNGLRLGIKLWAPDGYPADAFGEAWDVIERDLAGIKAPLDNLSSATGSETEHYDFAPLQLFGSTYELGVTYRPNVDFEVEDLESVLSERFVDMDEEWFTPTVARHRLESERSGAGSGSNTTSRSASRAGHQTPSRRTSIVVSGTPGATPGSLGAGKWSAMAEGLPFAIRAGAGAGDEPPSPQATIPAYRRLSAHSLQPFQSISASPTASVLRGQTPNLPSSAGAAARAIPSSAGSQPMARTSSFLSQSGRSHSHAQMASMQPSTSHETPMHQGTPPLGPPIGVSPPTPFPASPSVSKRASIALASSSPFVGGSLERDSPLRRGSLGRSPNSPMLRRTYTRESRRSLDEPSGDSDDIHAFLRALDSWTPPASVGQGSGNVAGSSGSGQGSSGAADSPARSVQRDRVPLTRTHVDDMLKRMAGSFQSPTPGSNSGPSSASNTGSRRSSLSGPSLTRRPQRLERPGLLSASRPVSTASSPAPTRGISTLAHDPEPEPEVDSSERGLTRTSTVPVQAAQAKPKLGSGEARSLPSETPLRPPRGPMVVRGGFGALKVGKPCSPSHSPVRDRGERKLERELPKGVGGITDRSGGAAGVGGVPSSRESSGDKPREGSLASQATASATATSTEPGAAATASAASGETRPGIQRIRSSVASGGRGSLSRSAGSGSQQSPVFEGLMAKLAQSKLDAQERERKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGN8</accession>
    <name>K1VGN8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGN8"/>
    <dbReference type="HOGENOM" id="CLU_027594_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGN8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="79094" checksum="FB1F0A7B728D99D4" modified="2012-11-28" version="1">MFVRRSQSLAPLQTDRTWYYVSKNIEDFLREHDAVTLHSDQTNVNELFNLLSVHLGPKQMRISVAATNLPSPYGADLPPSKWSETSSTVQPKKRSPLPRGTCKLSGVYRWPFDVDESEEAVPWALRRLIESSTLQGFKRRRGLAHFPDDFQENRYNVLFGPFNRSGLVLSLRQCKALPCDVAVLAIDTREKWLHYIERGHGRFLITHFPPLSHVVGTMVDEAAFTDEVAMDVYGIFDDCTVGLAVQGSALPALIATKPSSDELDSISIAELPMEARGINGVTVLFLACLVLRAGAAASKLLNMQKAGAVILADMADKGLGWVMQPADLSAVVQGWIGDALHARLAKFPLPRVALLLEAWAVRPSGLYISVSNRSIPDYERLAGDIRRLAPTNCLDANSSLRDVGAHLAFAAVFAGCSAGTALAVISRATTQGSFPSAVSTSPENAGNIWPEEHLLDSSFITENSCLRFQARLQRLLGGLKKPNRQDVLDQIDKSFTQLARGVTGDLRRELRLLFYRSCLVSMTGGHLVDDGRRPLTWHSKSLRQSARVTTAVHRAQPEPVPIEWPPLPVGNGRSWSFTVVAVCVIGMLVLVTVSTRLPTSPTAHSSSSQRQGVSLLRQKPMYLGMGRLEGTYLAGDEMIVSAGDHVYVLEELWEDWYKIKSLEGHTGVRQLAYVLFNANHSWFLNPSCTLCCVIFSPLGDAVSSGHAGAIGLYSTVDLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGX9</accession>
    <name>K1VGX9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000255">
        <property type="protein sequence ID" value="EKD03380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGX9"/>
    <dbReference type="STRING" id="1220162.K1VGX9"/>
    <dbReference type="eggNOG" id="KOG1780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2470668_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGX9"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="88" mass="9464" checksum="065664CD7D9A7A6B" modified="2012-11-28" version="1">MFLNLVVDQAYEELGGGERKPAGMVVIRGNSVASMELLDSMRQSDRGKKARNAKGQSARQRVAGKAGEFDIVQAVNFELLVASPLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH43</accession>
    <name>K1VH43_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000347">
        <property type="protein sequence ID" value="EKD00126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH43"/>
    <dbReference type="FunCoup" id="K1VH43">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH43"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_51_2_1"/>
    <dbReference type="InParanoid" id="K1VH43"/>
    <dbReference type="OMA" id="KTIAWRE"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="148"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="663" mass="70957" checksum="545D16CFBD49C19A" modified="2012-11-28" version="1">MSANQPAQADPPPGPGASGPTGTSGVAPLGLDTPTTTIDGYEVKPDSLPEGEGEKTIAWREEKLEKLEELEPTIPSSSDGKSDGKLDATGASHTGLSGHGGKSSDGDEKNPGHSGFVAFGKKMGELFGVFTPKGRPPGLKWRSASWFITAVVAVGVTMDVLAYAIIVPVLPYRLQALGHTGIAGKMTWLLFAYSAGIFICTFPVAFFFHRYPFRRGPLIVAVLVMEGSFVMFMLANPYWCMIVSRFLQGACSCVVWSVGLALICENIPEADMGKHLGMAVSGMSIGATIAPPIGGALYKHLGWHAPFIFCIIVCGVDLAARILVVERKDLPKWGVKLDAEGNVIDWGRGEETAETKTTFSGDTKVAHPPPSEPIGAEPHVKPTDPEDIDVIARGGALETAIAREHVEENAMLPEKPVELGPIQVLITLAKIPRGTVAFLLVFIFGFIIGAYDATLTLRVEQVWNKDSDFVGLIYLAAAAPAFFCGPISGYLADRIGPEVVLIPCLILVLPWMPLMILKTSLPGFMVFFAVLNCVATVLNVIASIEMAIASKYRPGISEIHEFAALNLAFAVSSAIGAIVGGQIYDAASNGWAIVCWICFAVFAVAAVPPFIWTGSRPFLYRMLRRPAPLHCFPPSERDAIAEKRRLKAMGKEPEADAVVVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH54</accession>
    <name>K1VH54_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH54"/>
    <dbReference type="HOGENOM" id="CLU_1403342_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH54"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21400" checksum="63401ECF3F3D2AFB" modified="2012-11-28" version="1">MTPGTRVSPEEHRPSGFVLERGVRHHARGSQPDELEEPSRHALDEQGGMQDCHVPYAPCRSSSSATDYCAPTSYLPPLHPPASLHAFPAHPWITLCTLGSQRALRIKDKSGSWIARIQGIKDRILQRRLSARKESRGLLVGNQDSRGSGKNDPDEDIDQPATGYSSFSQLFCHASPPAELNAWTATLKKVERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHI7</accession>
    <name>K1VHI7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHI7"/>
    <dbReference type="FunCoup" id="K1VHI7">
        <property type="interactions" value="326"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
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    <sequence length="408" mass="44907" checksum="F71C5635B92DFC82" modified="2012-11-28" version="1">MTSAASEAPPGYELAVSEEIFRASTSSDDSLRDNPAKPVNVKSGDSDSDDDDLVVHEHSGLQSAGSGSSPYQHQLGAASRTHLASVGEKKALFISSALIFVLFFAFLFHLEKYSLRLVLVIGMISFGVFLMVFNTTAVSLPGIIMVFTASALGGLRWALTELIMHKRAMGLSNPFATIFWLSPLMAVGLFFVSALAEDWAGMFRQFFHGIEALKNIGVIALPGFIAFGMVASEYFVLQRAGIVPLSVAGIFKEVSTISFSAWIFGDELTPINIVGVVVTVCGIALFSYHKYQKSISQTVEIDETGRAITHDGLDDERTPLAHGNYETEERSMRTGSTPASRPESVRLHTLAPSTDDDDEDRVNRMRDDFEGWDHPGSEDEYEPDDDLVEAMRENRGRSKWAEWWDKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHY5</accession>
    <name>K1VHY5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">A1Q2_05283</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="EKD00446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
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            <end position="1256"/>
        </location>
    </feature>
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    </feature>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EKD00446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1930" mass="214085" checksum="68D88914F20EF9EE" modified="2012-11-28" version="1">MDHDAAGQAGPSAAGPSRGRALRNRPSDVSYTDKRSARPSGRAVSQEEMERAIWKLGPEGMAARREELIHEKEALLRTVVEEHDMAVKEKFHLERYVSILEGWDPEDAKNDNSPVFLEYKNKDYDLLSLIPNSIIPGVQPAQAFGRARTTRRQLQQKSNMVGNVTAIAKPTPKGKGKAKAVPEPEPEPAAPAATASVKGKGRKSAPSATAEPESEAESSRAPTPALKTTAKGKGKKGRRATMHVEPETELTTEPEEQPVQKGKKRGRQSMPNLPAKKVRALRKSEPSATASPRSSSPAQTPAKSPTPEPEPEPVALPSLAHLPFPPPPERPKWRRSGPSRIIYTDPNQRPLTKQQHDGDISKILESYIHIEDTGPPTTMQFLEQAALRAGWLRNRVNWLQHQGRLLRLLDEEDEGPETKVRDRSHQKKAPVGPPPRATDFQDSLMSHMVQVRNAMIYEAKMKPQVCKRIARGIQLYWEHIQNKDERERQAQEKERKRKAKDMVKGLRKRWGLAVKIAAQEKLEQDRLGKEHLQNMLQRSTGLLEGQRDHMMGGGEEYESDSDDSDATDDVSAAEESDDEEAGDVDMEAKETDAGPTAAESEVADDLSEEESGEEGSGSEEEDEEDDESRHEALRLLVGTAGEEPETPADITAPPSDEAEPEAAGDLTLGDTSLVLVEDVLASQPSTAPANGTRPVPAVDTDDVEKAPLTQGPDMDGPTENDALASAQTEEILASSPGPNEEQAEEELPPPRPRSKRIQRRSLAAAASTPDPDANDAEFHGSDSERDAQDAAFDVEMGENAASDADSEDEGLLKDAEMPIEELLKRYGYPMPGMEAEAEEAVDAEGDESEAGAPTGEDPKAEDVQEVAKVSVETVKETIAETEVEVDVDTEAGVQELSASVQAQTSATATVRAVAPEEAPLANGSQESSAQPNGHTDASGLGPADTDSMTDQHHAAGVEPTVDKSLTDEALAHRGSSPPGLIIEGKRQRRARQVWTPPDTPQALISNKPKKPKVQIIPDPAPDTTEEADAKEESDVEMESTPEPTPSLTSSEEVTDDEEEVEEGEPEPEDPNAPKLKPPFLLRGTLRPYQQAGMEWLASLYGNNMNANSRKTIQTIALLGHLACDKGVWGPHLIIVPTSVILNWEMEFKKFLPGMKVLTYYGNQKERKEKRVGWNTENHWQVCITSYQIVLADQHIFRRKNWCYMILDEAHNIKNFRSQRWQTLLGFKTQHRLLLTGTPLQNNLMELWSLLYFLMPNGITADATAVVGFANHKEFMEWFSNPMDKAVESGEAMDEDTIEMVNRLHTLLRPFILRRLKSEVETQLPGKFEHVVYCRLSKRQRFLYDEFMSRASTKEALTSGGYLGVVNTLMQLRKVCNHPDLFEVRPVRTSFAMDRGVATDFSPLDVLVRKRLLEANDELDIGALNLSVTGHEAESGWVAGMRARLDASDQLPFADDAKPTKAPKFDTRTPSGWAKYREWKQQQQSMERWRALRDINRRRCQSGPIYGRTTLKMLSDLPNYLLPASQPHGISDQYGEHPPPAAPLVRSYAEREQLVTPLLNKFAVIPPNAVARDVANLALPGVDPEHSSLTDPEFDTLHDATVRLQIAFPDASLLQYDCGKLQKLAEMLRDLKAGGHRCLIFTQMTRVLDILEIFLNFNGHRYLRLDGSTKIEDRQVLTERFNSDPRIFCFIASSRSGGVGINLTGADTVFFYDSDWNPAMDKQCMDRAHRIGQTREVHIYRFVSTATVEDAIWKRQCQKRELDRMVIQDGDFTTDFFAKTNWKDVLQDEAAVEDDDRIEDIEVEAAPEAEDATVAEPRLGQQREFVEALAEVEDEEDAAAARVAQGEGEMDFAEFTDKRPERPVARQAPSQSLAPSASVPASGSATPAPGAAVAEGEDDEYEYDEDEPGGVDEYMLAWVEHDWDYFINYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIN0</accession>
    <name>K1VIN0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIN0"/>
    <dbReference type="FunCoup" id="K1VIN0">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIN0"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="InParanoid" id="K1VIN0"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="535" mass="59081" checksum="1052AF1CC18B8E51" modified="2012-11-28" version="1">MEPRNLDHRRANFKGRTQFSAQELRRRREEAQVEIRRQKREESIAKRRNFQPVSDDLDSDDDVEDLADAQLGDQLPQMIQAIYSNDQETQLEATTKFRKLLSKEKNPPIDRVIEVGVVPRFVEFLSSTNTMLQFEAAWALTNIASGTSDHTQVVIAAGAVPLFIQLLSSSVLDVREQAVWALGNIAGDSAKCRDYVLNQGALQPLLQLLSENHKLSMLRNATWTLSNFCRGKSPQPNWELISPALPVLSKLIYSLDDEVLIDACWAISYLSDGTNDKIQAVIESGVCRRLVDLLMHPSTAVQTPALRSVGNIVTGDDLQTQVVIMSGALPALLSLLSSPKDGIRKEACWTISNITAGSPQQIQAIIDANIIPPLINILQNADFKTKKEACWAISNATSGGLSEPTQIRYLVNQGCIKPMCDLLQSMDNKIIQVALDGLENILKVGEIDKENAGPGAVNQYAQYVEEAGGMVAIHNLQHHENLEIYKKCFYIMDKFFPEDEDEEEGDAAPAVDSTGQYAFQSNVAAPQGGFNFGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJB1</accession>
    <name>K1VJB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000332">
        <property type="protein sequence ID" value="EKD00866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJB1"/>
    <dbReference type="HOGENOM" id="CLU_2689557_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJB1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="74" mass="8612" checksum="A211807E5AA95FD5" modified="2012-11-28" version="1">MKPQRVVYPYYSYVPQVEYSLPREYRPREMGLGHGHPAHPQHVAMPAPQQPEEQEDQKPIIMPQPSKPNVLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJE6</accession>
    <name>K1VJE6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJE6"/>
    <dbReference type="STRING" id="1220162.K1VJE6"/>
    <dbReference type="eggNOG" id="ENOG502RBF4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438865_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJE6"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="623" mass="68088" checksum="F84C3971651A2687" modified="2012-11-28" version="1">MTGPGIFALDLKTSVGVILGFNAVMCIFPAYVATNGPKTGMRQMIQARYGMGYFGAMVIGLANVLTLVFQQPPAFMPPIHQQMAQIPTAVYEAQKDPRRRARQAQTAIASPVPSAAALKPICSAQGCFPDQRNVVRPLAVNLLAGATKNPHGHYLLSKLPELSKLPDRQEQGPPQFTAMDCRCIDLLLNQGGSISEWCMAGPSANNSTEQVAVWNFAAGYMAARGKLFVASDELVPTWPINTRDFIMFCEASRVDVSKLQGSVQPQKNQILALVLSIPLNSHPVRSLPNPVRPDFTVGEIKSTVPPELPFRPQNLADSYGIDGDGLGKLKGSIQVYPSVRNELYRDTLANIKKAGLKPPPGSEAGSNILLFNAHWGQIVRSGSVAKGMEDNSKFYIAGPDLTLPADQWLLHPIWETGGLVTFSPTLILSDPVKFKETLDFIANVKGWVAYVHPSTVMWCQESWGNKARCPNPSVAFETFVSSLFTEDKVRKLAGTLPPDAGGLAVSHAPPSLPRKGDCNKWLSWLRKVFESSNYEELVPLCKEAHTAQQAMMYPNLGENDAMRLSTVEEIGLRDLIAMRERPDLLPYRRYIYVGGLSKSPPDLIRSVQHVQVDNFAAVLSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJF9</accession>
    <name>K1VJF9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJF9"/>
    <dbReference type="STRING" id="1220162.K1VJF9"/>
    <dbReference type="eggNOG" id="KOG0884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_38_1_1"/>
    <dbReference type="InParanoid" id="K1VJF9"/>
    <dbReference type="OMA" id="XHSVRGV"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="115" mass="12365" checksum="4700E4665FFE6072" modified="2012-11-28" version="1">MVQTGDPTGTGKGGQSIWGQPFPDEVRSTLKFNARGIVAMANAGPDTNKSQFFITYAKQSSLDGKYTIFGKVIDGADSTLDAIEKVPVNAKNRPLEEIRLESVTIHANPIAEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJL2</accession>
    <name>K1VJL2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06318</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6 8">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJL2"/>
    <dbReference type="FunCoup" id="K1VJL2">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJL2"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010374_2_1_1"/>
    <dbReference type="InParanoid" id="K1VJL2"/>
    <dbReference type="OMA" id="SIANCDV"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="635" mass="70092" checksum="E4C59F6416E81C39" modified="2012-11-28" version="1">MRILTWNVNVLRTVLDYHPMPKKNVEGLLDTLEADVFCFQGQVSFLTPLTSEHKTRRELLDKATACPGRYDGFWTFPRHKSGYSGVCTYVNSDYCVPLKAEEGITGLLLTSKGGTMKPPWTPDEQIGCYPELDDVPLLEETEGIPFDPARLDVEGRAVVCDFGLFVLFNLYVPNRGSEARGPYKLNFLTVLRARVEALMAAGREVILAGDMNVIRQPIDFGEGTIVPGTHYLDHPDRLLFESWCHPKGPLIDVVRESFPDREGMYTCWNTKIDARPANYGSRIDYILCTPGLRKWIKGGDIQSKVFGSDHCPVYIDLHDEIEENGRTIRLKDVLNPANRPQSTAPKFPSDVPRTAPEPPRFATKFFDEFSGKQRTLKSLWANAKPKGSSSQATEQQPLVPSPSKTPTPTPDPTTPTPAEVAQTSSTLGVARAAFSSLDSPSSSAQPAVQAQTAAAVKTANGAPKRPATIDLTGDDGPRKRATVERSKSSTMKKSSNGQMKLASFFSQPAPKAKAASPVPISERAQESTLAAVQGDIPDTDRDALIAIAMAEEDEEREKQRDAQKQKNAPAWSEIFAKKVPPKCKVHGRPCKDFIVKQGSNKGKRFWLCSLPVGPGYDMGRSKRPREQVNPEYRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJW6</accession>
    <name>K1VJW6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000327">
        <property type="protein sequence ID" value="EKD01046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJW6"/>
    <dbReference type="eggNOG" id="ENOG502S672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251355_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJW6"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1534" mass="165343" checksum="EE907B31A777ECE2" modified="2012-11-28" version="1">MAGLMKNIFRFSRKDPEPAYIEPSPPPEDATFSSHHEYPEYSEEFTPYPFFPTPGDKELNAAGAGFGVDAGPHSGQRGVPLDVPQPPVQPVQQQQQRQAGFESYPYSQYPLSPPGDPQNYPQAQEQFAQNVFPPSGLQNGHAQPTGRDFSPDKFAKTTLKSASGIAIDFIPEESEPDSDTNPTRRRGYELGTRPPPVPPKSPLAQAVPAVPAVPKPPLSQITQASENSAALIERHRDAIQKVAARKETDEAEAATPPKTQHAKPTKHQQSMSFSALATGQQPQAPSSGGKDSVLSRGAHNRHSSWGGSARSGGVFSEDEPLPEPQPVRHPAAPVTVANEQLTVENLSLFSQQSPKPLAFLPPNKRPKAKGKAKDKTGKKDKEKGKGKGNEKEKAKEGKSDKPVMLDKVDKGKGKATNEELDALFDNSKFDLLQALENVDRFRAEGPGADNIAHMRTLAMLSAATGGALNNFNVPEQKDANTSGENSGDAGEAGGDADTLGETGDKRRMHNSFHTTTTESFGHIYHRDGRPVPPPNAGPSGRFSHHRHHSSGGALADISEATESRDAKHQVTTVEDVPDVPLGARAPGAPVSAAPPAAPALPVVTAPVHPASPEELEPKIPDLEREILQAGAPPPPTTPESEASSSFTKLQGLLDRSSFHDEVLCQLLDAIHNRLIGEEAQKALIRAAKARVIELKDMKARGGEIMLSPPRGSTKPLKINKRSKPAKGEEDNKQKVEEFKAEREKTRLEPPPMTREPSQDLPSVLHTPTDELASSGPASSSRSATDGYMPRTETDMTQDWTKKNGLKSWAFKPARKKTAATTDSTGLPSLHGTPFTTGPNPTPMHRDPTPPNSYDAHLQNTYTYTSPRKSNPSPWTGGSYGATGVPSHGPSTSFGGHPGQDFGGPLPQQNFNSFGRGHTPAASWRGPDGAYTTPAFTQPPRDARDTDQTYTSPEMARAGPSFGGLPGPFAGMNPIPLAGPSAGFDAPYRVERFSMPVSDEELRTTADIINGTRTFVVPIGSLSGPGAFDFLDGPFPLGFALPHPHPEQDPWDKSASIHTLYSELPKESTPPTKKDGDAGSDTSRAPTVPPKDTPKISQKTVPATHPDTPKTAPVEEKANTSKPASPGKTPRMADLHLPSDPGAAPAIRLQAPTTTDPTAVTASKSTSTPATDVTAHSAANSSFERPKWDAAPRESFRTAQTQPQLPAYQSQPSSPQKPTGQPFFPPNNRSAPSSPKKTSAQKTSNGGPNGTPVSEKARKEKQAKEPKRHSGGDNRQPQSAAPSYSTTHTLRGIESVMSPETMTTNISRELKQPDHITERLYAWAREKSEVDFVETLERLSGGDEELMADPRVPAHNIHTPDVEAAKLERGAECDRLLVPPELCDAINRAVQAEYNDAANYLLQAWAPFGRERAPRLIISLHRHGVQQDAWFANRYDLPALKMLSYHVSASSDESPDPRPHLWWNAIARAWPDLTLPDAESEPGAFRVTSTNVLEGKREDASTRAAVVARNLLLSYEPTYEHDLGKLRELIVTETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJX5</accession>
    <name>K1VJX5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJX5"/>
    <dbReference type="FunCoup" id="K1VJX5">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJX5"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_6_1_1"/>
    <dbReference type="InParanoid" id="K1VJX5"/>
    <dbReference type="OMA" id="RCLMGYF"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="7">
        <location>
            <begin position="162"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="636" mass="69954" checksum="0DC9D7536E899859" modified="2012-11-28" version="1">MSQPPVPPPPASAPPELVDKALEAIASGEVDERPSVKRNPSGGTPEPGTLADAISKIDSLRLSRAPSISSNNTTPPTRSGASSPGHRNSMSADISGPPSQPGKSPAQTPHFGATTGLLQTLDESTKVIRQNAVGLNRAPSVSGIGTVVEKPDYSEAKIVVAMWLEYKVEVFNVGQLRRSKARAVQEAGGEKTDHSANYFSANNADAKASREQLAEESLESLIAWLKKEGNVGIMDATNSTYERRAKIRDRIAKEPGLQLLFLESYCDDPDVINANVALKARSGDPDYAGMSTEEAMADFRKRIAQYEKVYQTIDEPDISFCRILNVGKRVTINRIEGYLQSRIAFYLMNLHLKPRSIYLSRVSFEMCLANCSQHGESMYNVEGKIGGDAELSPRGQQYAAALPDMVKKHIGDGPLEVWTSTLTRTIQTASKLPFPKKTWKSLDELDAGVCDGMTYEEIEREYPEDYDARDEDKFNYRYRGGESYRDVVVRLEPVIMELERQQNILIVGHQAIIRCLYAYFMELPQEELPYINVPLHTLIRISPRAYGCEEERYPLGIAAVDTHRPKPAKFRKPESERVDHTKRDYFGSNVNSAAMSTQASETGTATSTETGSKAPDSAPKPADPAASHAPVPEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK91</accession>
    <name>K1VK91_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01157</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK91"/>
    <dbReference type="FunCoup" id="K1VK91">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VK91"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="InParanoid" id="K1VK91"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="181"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD04585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="491" mass="53775" checksum="8362E8F924F00489" modified="2012-11-28" version="1">MSEAVADIGLIGLAVMGQNLILNMNDKGFTVACYNRTVSKVDHFLANEAKGTHIIGCHSVEELCKVLKRPRRVMLLVKAGAAVDSFIDQLLPYLEKGDIIIDGGNSHYPDSIRRCKELEAKGINFVGMGVSGGEEGARNGPSLMPGGSEAAWPHIKDIMQKTAAQVEGEPCCDWVGGTGSGHYVKMVHNGIEYGDMQLIAEAYDILKRGLGLDEDEIADIFAKWEEGVLKSFLIEITRDILRFKDTDGKPIVPKILDKAGQKGTGKWTAIDALDRGIPVTLIGEAVFARCLSALKDERVRASKIISGPKPEPFQGDKQQFINDLEQALYASKIISYTQGFMLMRQAAKDNDWDLNNAGIAAMWRGGCIIKSVFLKDITAAYRQNPNLESLIFAPFFAKALEQAQAGWRRVNAQASLWGIPIPAHGTALSFFDGYRTAVLPANLIQAQRDYFGAHTFRVMPGQENDHLKDGEDIHLKWTANSGDVSSSTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKU0</accession>
    <name>K1VKU0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKU0"/>
    <dbReference type="STRING" id="1220162.K1VKU0"/>
    <dbReference type="eggNOG" id="ENOG502S8KV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888996_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKU0"/>
    <dbReference type="OMA" id="KEYHNEN"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="313" mass="34649" checksum="EC74C1BA1E865346" modified="2012-11-28" version="1">MSKYSAASASQIPTIIPPQAAESKRDRKRRETVNKIEMLHNGSWNNRDEKFSQQYKEYHNENKAVNTQPPTSSKYMLRLYPKTVERDAFLQAAQTHYEYKVSQAQKMYESERDNIEGMYWEARDQIRQRLLGAIEERRRKLREEKEGGDVVTGMLAATPNHHNLQSGADSGSASPKDGSKSNDLLLHNMLAPALAVINTDDILYTDSSSLIVKALPNGYNVQSGKRGPRGKAAELEKEGPAPGTSAALAIASGQAPAPTTNGKRGAGAQSGWVLGKALNDMKRMEEATLLERDSDWARIQGSQHGRGRRGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKU6</accession>
    <name>K1VKU6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKU6"/>
    <dbReference type="HOGENOM" id="CLU_1769399_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKU6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="147" mass="15833" checksum="9F7FA593A0FD0677" modified="2012-11-28" version="1">MAHEYYPYYTPMPVHLSPAPMPVPVSAPISVPAYPSPYVYAYPAPASPYAGSPQSAHSAPSVHSVPSSYSSQSSHSSLSSHSALNPITPPYSPYSPPSPYADVPFPHCHSPESYHKYAAQLHYASLTELEACIEAQDIGRSLDCLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKW0</accession>
    <name>K1VKW0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKW0"/>
    <dbReference type="STRING" id="1220162.K1VKW0"/>
    <dbReference type="eggNOG" id="KOG2149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013988_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKW0"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="654" mass="70570" checksum="5C9FE49B2A722E0C" modified="2012-11-28" version="1">MPKATKKKKEKVEDFKLKLGKGKKQASNATDTSFKARCLTLDDVLIQMRHVNAGVRKESLNHLREVLQAGVRLGINFGDRHGEVSKVVRAIGGMVTDDALHGFIEWYIARLPRTTLVPYLPLLELQIASALSHIYPAVRLDACKVVEILLDTHPAEVIGSWPAPSVSSSVAGSGSGSTIFEGLRLAAGLGGEKGASTQGGFRLTAGSKLVILRAIRTFIAKALEPLLAAPELSHPEPKLGEFTLQKLEVLSAAGPWSLGEYDWATQWEEPDTSSAGDIASPEALNEISRTYLSLHSLLVATFMEAAPSAFSVSSTATTDQVALDLCSVCVDLVTVCARALLGQADFASLDSAKELRSAFSEFLKRMAAYFPFGRGEGAASAASDAVFGMSLNYAKLAVALAPVPPAIAPQPVWKRRVRAIDTAWRGVSNKSDPALAAAADWVASCLEPSTDALAPQLSPTSYAELLPVVRSLLLRPSTAELGTQFVHAVLRQQSASAKRRASDAFLASLFHTHEDRWGTLPFFVPLGSGLRAGFAKWLQSVPKTLWELGNKDQEATEQLLRFLLDLGRRAPNGLEKPYSLVEAGELEGLAAKLAPFFWVAQRSMLGPWGRLDDGTQRLALDVARVWAPMDERLGAAVAEAVESRPWATEYWARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKX9</accession>
    <name>K1VKX9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKX9"/>
    <dbReference type="FunCoup" id="K1VKX9">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKX9"/>
    <dbReference type="eggNOG" id="KOG0903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002446_2_0_1"/>
    <dbReference type="InParanoid" id="K1VKX9"/>
    <dbReference type="OMA" id="ANYFRCE"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854202" description="1-phosphatidylinositol 4-kinase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="775"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1080" mass="119205" checksum="D8262849032007BC" modified="2012-11-28" version="1">MSHALLLRLFLSPYFSVSVALHYLKTYPESIGISHYLCWRMKSMPFEEVEFYWPQICNPRPFNICQRVLHRCHEILFGDPPEPSRNPYRSLPTSPHASSPSVGHIARPSSAAPFMGREPSLPPDERLKPPVRVNANLGAALVGMGLMAAGAPAMPQFTELAGEWAVTQGRRPLDDAAASRARIEVDTSGGADGPRGDAWNRKPKQISGQESDTDDDASSVSNIDGVTRSDTKINRRPTPPMRSATTQPEASSSPSRPPLVNHVSTTALNLLSQEEDERGRDPFMQNTSTPPLSSVFRKQTTHQPFHSVPDMSLNRSLGPRVGAHRPPSAESLLAAYSLAAQRQLLKSHYTRSEIRFLLLLEDICNRLLVIPKPARISALRAELTSLNHNLPAEVCMPLWCNADHHRNEEPSPTSFLGKPKQPKRAHSRVVRISPGDSVVLNSAERAPYLLHVEILVDDLDFDPMKRENRELLKKIVVAEDLKRRKKEEGFDHHVPEGFGSAMPAPLSAAALGGDSATESPAHSRSQSHSRAETGDATGTPIEEIPEGPEEPEEMDLVEQLFGNKLSVRDNMVDLSDSMPLPAAPKNKQLDLEVWNKEDHSRRSSLGSGGVPGTPNGELQPEGLGARPITPVPLEPTISPRAKPVITMEDYSERMRTAAVMLAQLNASLVPPNPEHSQSGSSGVRKWIPGTGWITGSNKESTEPAGPAGGAAGGKLRLAAAEAARIRERIMEEMMALEEERVSRMAAIPEGVHVEQADGNQTVEDEGIVRREINKADPSAAVFKESWAAKKSRIRASSPWGHLANWDVISVIVKTGADLRQEQLATQLIERFTKIWKDEGCECWARFFRILITGETSGLVETVTDAVSVHSIKKSEYSRRVAEGTPIGHVSLMDHFMNTYGKPDSGQFARARRNFIKSLAGYSVITYLLQIKDRHNGNILIDRDGHIIHIDFGFMLSNSPGGNIGFEAAPFKLPLEYIDIMGGFDSPGFELFRKLFKQGFEAARKHSDSLITMVELMQKDSKLDCFVLFGENTVNHFRDRFCLGLTTAAVDQYLDRLIVSSAGSNYTRLYDTFQYYSQGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKZ9</accession>
    <name>K1VKZ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKZ9"/>
    <dbReference type="HOGENOM" id="CLU_1176134_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKZ9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26393" checksum="DEC56B7ED6DA16C9" modified="2012-11-28" version="1">MSDIKWHPNWPKQDNAEGKVTVIGSDGTHFMVDDRPLFTEILRRTENGHTMIDLSGDPLATSDSVNMFLKLDPDPRKGEDVDDWSKLNDPAVCAKIAGMLAFVHAYDYPIPQPGMGPRHLLEGIGRRVELFAAARSIPLGWAYAFAGAMGDPRVACAVHKESVYPGRWDVKADPLKPNHIPSAGLPAMNVKYMAVLALAAERRDSTEAMRNALEDYDDLAAKRGPIGAAERLLQESGKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM54</accession>
    <name>K1VM54_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM54"/>
    <dbReference type="HOGENOM" id="CLU_483280_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM54"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="564" mass="62204" checksum="F62770820AD8FC8E" modified="2012-11-28" version="1">MSSFSDLSNQVVLLPVDRLYLRLALGLKYDFSLETVPIEHSAQCVEVELNLDALFLEHWLVLPAFIGPSTRCLHVRCYGDTWFDIPEEEDLIHAGPPFDSLDIFTLFTGTEYGFGSPGHRAREDVKAALRGSMVVAMPRATRWSTGLETWPAKVLIMTAVTKEVSTLQPRALKTADLKPKMTTQEFLEDLHTTHLSQKEHSEAAAKSAALEDDTGDAPIPNGSSAVGETDRTTSDGGQSSQASSSSDPGIDYACAFSLVISFLDWSTLLALRGVCHLIKDAVDDYLTVPEMMFEIRPPKRPNAFLVYACIGGFDRLLPFFANASGSARQMTALRQAKAISLSGRMHPIVNFMFTQLTASATVFIDLVTGTSKCPIDLPPIRRLIIGEDQVAAWSGLALGLHVRHAAQEVEVRIPLGGSWLDWALGPLLCQTAFSSLLRPRTQRLTLRADGRVAAFLDTVKLLFPVSAHPNLNIAVALRTDEWWERVQPSGIVARRIAAVFGVRVQQVSAQVQDAGALMRWIQAAAIEERRREIARQLAAVEEETPQEELEDWEIDGDWFGKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM95</accession>
    <name>K1VM95_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peripheral protein, Mdv1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM95"/>
    <dbReference type="FunCoup" id="K1VM95">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM95"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012350_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM95"/>
    <dbReference type="OMA" id="ERLRYMD"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="593"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="624" mass="68734" checksum="EA6227781122D686" modified="2012-11-28" version="1">MGPVQPTSSTGIQILERADALTRLSLDDEAPTVSLIRGFKATIPTSELSKQRRRLIRGGLVDEDLGGKLGLKALGDRARGLLTDGSDEIEAQHEAKRKDKRSRRKKLRERRSTMAHLEGKLHLEDLLQQADEIAQDKDNLAVRQSLINAEINEVSSKIEQLAEIRKRLEASLLKLQEEGLELDDELEGIQELMASPSVTSAAGVKALPPSAQQTVSSSSRRRKGPAFLPSEHDELPSGVAFLTLEGHTAPLTALDYDEPYGTLVTAGQDDAVKVWDLCDGEVLGELRGHKGAVKAVQVEDTLCVTGGEDGDVRLWDLRLVEDYEEKLAKAAESRNPLDRIAEEKEGSIRQGGEEEEERNPCVRTLEGHSKSITALYYEDSTLVTGSADKTIRQWDVTTGQCVQTMDILWAISNPPVIPLSPRKSRRKYSSSSYASAGYDDLLPSLDSPGAVEEPISLSGPFSVPTPPFSDGSWDMYTDFVGGLQFWGYALASGSGDGAVRMWDMRTGQAHRTLNGHTAPVTSLQFDEHNIISGSLDKTIRIWDMRMGQTVELHKYEYPVTCVQFDSRKVVACTGENGIEVYNRTTHEHSRLIVNGHTKPAERMRFIDKYLVSGGKDGTAKVWAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMV1</accession>
    <name>K1VMV1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMV1"/>
    <dbReference type="HOGENOM" id="CLU_421615_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMV1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="650" mass="71392" checksum="9A1435F9274444ED" modified="2012-11-28" version="1">MSANSPIRGVPQQVAEPNYFIQRFLRSVQPFYYQHAQYGQEYFERSRRTGDKLLNEDWELAAQWSPESTNSALPQYLQADPIVAPSLPSSSLLGTTQPVARQHSTSPGLGPVDNSSGRGKHSRPRTGNALRTAPYARRPKEAAAPVYYSHHASPASPGSADDLGESRRHAGAGQERRVVSADDNVHIALLKQQYNERRRRSSEEQEQVLASVTTPVENNEKRSRAACPPDLDFGHTNTKPRTIQAEAGRLTLHPVAAPPADVQHPRGIFLRGVASHPVTVSQHPPVPDANARAGTGGFDQLRFLGVSEEARQQQAPPSQQLAYPSTLATSDQPLPQASMRTTPSDIQLPPLRTLDTDALAPRYRETADQSYSWREGRTTPPHEAVGYAGFPSYAGVGRGESALPSVTVTPETTPESYWGSAYPTAARQSHVMDYQRQQQQYQQFNTQQVHSPYYPPPPVPTNDYAAYPYASWASTAYPAETTQPRESGTADRAVSADPRRYDDSRSWDRPYSAPPPLGRETSHLLNAMRGEPTTTRPRPVPAQWSVAADVQGSQGSPPRDPRRQWTPVGPETSQPVAAATAEWPEPITVPGSTPTWDPSPTSSHFQVPYTPQPYATPLFSAPTATSGMPPMIEKQLPPIDMYHTTATPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN21</accession>
    <name>K1VN21_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000301">
        <property type="protein sequence ID" value="EKD02051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN21"/>
    <dbReference type="FunCoup" id="K1VN21">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN21"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="K1VN21"/>
    <dbReference type="OMA" id="PNSSFWY"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="426"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="517" mass="56551" checksum="0F561C4CF002439A" modified="2012-11-28" version="1">MIYTSHHPVPPLPKTSVFHYLFPERPGDSPIHVHPPSTPAFIDGPTGRVLTRGELEDGALRIATGLRDLGIQGTALLIGPNSLDWVLAAYGLQAAGVTPSEIAYQYDNSGSSILIADPVLLPAIEEARKLFKNPLKQVLVLRRAPGYKSIHDIKGPRGKAERIDDVHQTAWLCYSSGTTGLPKGVMTSHYNMTCELQAVTVAYPKLTEKDRILGVLPLSHMYGLALLLQQPLIIGVPVVLYPKFEERPVLAGIERYRVSYAMFVPPIVLVLYHSAIAKEYDLTSLTRVNCGAAPMSDELCYAFEAKFPHCEISQGWGLTESSVAIGYNGAETGPKSCVGRLLPTWEARLVKDGKDVAPGEEGEIWARSPALMEGYHDNPKATADCMDGDWFKTGDVGRIDEDGFIYIVDRVKELIKYKGYQVAPAELEALLLQCPGVKDAGVVGVYSEAQATELPRAYVVADASPDFIAEWVKERVSNPKRLRGGVVLVNSIPKSPSGKILRKDLRTRAAQEMKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNB5</accession>
    <name>K1VNB5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNB5"/>
    <dbReference type="STRING" id="1220162.K1VNB5"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_7_1"/>
    <dbReference type="InParanoid" id="K1VNB5"/>
    <dbReference type="OMA" id="YITKAVH"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF185">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="38"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="494" mass="54967" checksum="536AFBEFB8CDF3B1" modified="2012-11-28" version="1">MPTHVEEVQPVVAGKGRDPTLPANHPINAFSPMRKMGIVLSLAYAGCLANFAIAICNVSFGWVTDRVLADNSEVGKSLGVGPGDIANALGYNLLGCGVGSLFWNPLSRSWGRRPVYLIGSFLFMPVCVWEALSKNYACFVVARIMAGIVTSWSQTIPPSSIAEIYVPQMRGSKMSIFGVAVVIGPVIVPIFAAAIVEHHSWRNLFWFNLGLAALQFLLILFFVPETMWNWEENTDIVEVDDKKDIVVEHKRSGYVGPAFLPHTDWKRFWPLCWSPIYMIHYIVITVPSFYYGICLGFLSVAPTVIFPQIFDKPPYSFAVVPLGCAFLGFGVGGVLGKWSGGHVSDMIVAYMERKHGRRIPEDRLWAGIPLLPLMFIGQLLCGVCVQYELHWMCFIVGAAINFFALSGITTVILTYVLETYISKGMDTQAVFNFWKYLWGFAVPFFTMKWGETRGWMACFCGMGAVLTGFGALMVAGLIWKGHAIRKWQNMPMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNV4</accession>
    <name>K1VNV4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNV4"/>
    <dbReference type="HOGENOM" id="CLU_1760075_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNV4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16299" checksum="E8A8E7AC4A9C1C96" modified="2012-11-28" version="1">MQRRQRNAYVTALCPLVSTALNRKLHNDDLVARTVHTTHTTTMVFDNKESTEPLLPAPATQPVQPVRARHALITFLDDSGEAVDGVAEQRRVVIFEGADAQIGPMQQPKSILSVLPQIVIMMVVLFVTGAALMTGLVWLLSYFDAFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPM9</accession>
    <name>K1VPM9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPM9"/>
    <dbReference type="STRING" id="1220162.K1VPM9"/>
    <dbReference type="eggNOG" id="ENOG502RYN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPM9"/>
    <dbReference type="OMA" id="AGTICRW"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852016" description="Extracellular protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="36821" checksum="A03636731B31F8AB" modified="2012-11-28" version="1">MIALSIASLAAVASLVVPANAHMEMTYPAPFRSKSNPHATEIEYSMTSPLNADGSNYPCKGFLSDLNGPGGAVTAEWTAGQNYHFTLQGGANHAGGSCQASLSYDGGKTFTVIQSIVGNCPSTVAPTDYPVTVPGDAPSGDAIFAWTWFNNLGNREMYMNCAHIKINGGSGGSGFSSRPTIFEANIGNGCSTLEGSDVEFPNPGPDLINQSSKTAPPQGNCAAGPGSGGNQPQSSAAAPSPSSTEGGAPASSGAASSDAAPAPSSTASYDDGQWHPSSSAAAPSSTDGNNGEWQPTSSAGSSEAQPTPTDGNSQSQGQSSATGINPPTESGKNRKKKCVRRQKRNGVHGHRRAGPHGGRSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPT0</accession>
    <name>K1VPT0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sedlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPT0"/>
    <dbReference type="FunCoup" id="K1VPT0">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPT0"/>
    <dbReference type="eggNOG" id="KOG3444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101893_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPT0"/>
    <dbReference type="OMA" id="CMEDMAF"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26625" checksum="BA3220DEE309D3D5" modified="2012-11-28" version="1">MGDRPPSVPLHLTSVAILGPDNAPLYVHAFTGPEDEMRAYHLAHAAVDVIEERIVMMSTPSRPADSYLGLLFCMEDMAFTLPSFVELHQLTPSYGFQTTTKLRLVLSVALVDAAIKDSDIVSVFRALHNLLLRVISNPFLSLPRSFHATPARAVRHTEESLAGLPPKESAGSAESAPADSAPSPDSPAKDDAKEVKNGKALRNEPIPQNRLFRADPADIRPEWFESERFKLGVAQLGQLLNGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ40</accession>
    <name>K1VQ40_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Siderochrome-iron (Ferrioxamine) uptake transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ40"/>
    <dbReference type="STRING" id="1220162.K1VQ40"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_1_1"/>
    <dbReference type="InParanoid" id="K1VQ40"/>
    <dbReference type="OMA" id="VMLNTAW"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="100"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="664" mass="72108" checksum="2B0276A216224D37" modified="2012-11-28" version="1">MSAAAPPVYEQANIAEKADLPSGTGPTPTMPPTSTAVPGLSSPESDGSSPMMERSVSLSKVRTNPNLDEKTAKVVYEKSPGILRIEAITSMFTRWHLAWLFFAIFLVSYCYGLDGTLRYTYQVFALAEWAASAQISTITVVRSIVAAAAQPAFARISDYFGRISILFISTVFYVIGTIVQACATNLATFSGGAVLYQFGYTGVQLLVMVIIADVTSTRNRLLVSFIPATPFIINAWASGPIGDRVSPGVNADGSARPPSISWQWGIGMWGIIFPVVALSLVIVFILAKRRAKKQGLLAGLPRGNPLSLSLWKDFFWTADVMGIILLAGALTMILLPFTLAGGVHSEWKKAKNIAVLIVGFVVVLPLFLFWEFRFATHPVFPFYLLKDRQIVAGLGVAFLINTAWYCQGDYLYYTTLVAFGKSIQQTIWTQNIYSFVSVIVGLIMGLAARYLRRLKCIVVIGAAIILIAFGILIRFRGGHSTSDYAGLVAGEVLLGIAGGMLSYPTQALTQAAVKHERVAVITASYLASYYVGSSVGNTIAGGIWTNTMPGHLATNLAKVTDNSTIATVVYGNPLAALEYPMGTPIREAIDLAYRDVQRYLCITGICLAAVLFLLTLTLRDIRLTDKQTNDEAEEWVAEDAVHDVSWRGMFKDPLGIIGLGKHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ69</accession>
    <name>K1VQ69_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ69"/>
    <dbReference type="STRING" id="1220162.K1VQ69"/>
    <dbReference type="eggNOG" id="ENOG502RB94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1129759_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ69"/>
    <dbReference type="OrthoDB" id="10605051at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="26634" checksum="A2C837AA98C86C2D" modified="2012-11-28" version="1">MPDPTVPTSESLTLSATLFHADVDSWLPANFGVSQPESSKAAEWESALRSSADRAQRLGLGHAALEDAALGAKFKNQRAGLSVLEQKLKKRKNAEESTAAGAGRDEEDSEEEAESRTRSIKTNKKSKDPFAGKGKVHPALAKKETKVHPALLKKSGAEEKVHPAILAKMAAASADSTDTSAEEKSEEKDEPSPPTSLGKRPRDDSDDETEEKKDDEPVLSKAERKREKKRRQKLRKAAEAEAAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQH1</accession>
    <name>K1VQH1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pumilio domain-containing protein c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQH1"/>
    <dbReference type="STRING" id="1220162.K1VQH1"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005652_1_0_1"/>
    <dbReference type="InParanoid" id="K1VQH1"/>
    <dbReference type="OMA" id="WLANPGQ"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000486">
        <property type="entry name" value="Pumilio domain-containing protein c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000842">
        <property type="entry name" value="Pumilio domain-containing protein c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000475">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="368"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="502"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="668"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="768"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1089"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1177" mass="125991" checksum="BD6D5BC5FD3D99F3" modified="2012-11-28" version="1">MASSLHAAEAKREGRTPPPAPSAAYAKRAREIIEDETGFSLDSATRGRPRAGTLPSSFQERELADNSKQSSPQRTSALQPAYLPQRPSLRHATSSAPALEHEHPRQRSGSTSEVNTAFASSAFSNAWLANPGQAGAKSPLGRGGDDYMETPVSNDLNFSTLDYLGLADTNASDDMGPASISELRSQHRRAIDAQGPASRIRASTVSNVNRPFRPSVTTAFDDAPNSLANAFEQVSIYDQLLPSAQIGGGGFPSGSLLHPKVAAARGEASRPRATTIGSLDNISGRGGLRGFLSSIPQSPLQGEYAANSAFGDASRFGYPPRSRSDRDLTRSREGSRDLRGHRLSISSQNSRTGTPDNAGSSTPQMPTRSLWIGNLDVNATSEALLRVFSSYGAIESLRMLPEKTCAFVNFMDKADAVRARDDVLNRLGGQVPELSETAPVRIGFGKIDSAPTGPTTSTVAPAPPGLVFTNGQITITQTQPSAGGATAPGPDAAGDQSALPTRALWIGSIPSTTSSATLLQIFSPFGPVESARVLTHKSCGFVNFERLDSAISARNALNGRDILGSDIGPIRIGFARVPTKSPQIGGPEPEEGSSPAKLGEGLNTVRGATAVTTEQQLSTEGGGVENYRSQLVLDLVKQGVHEQVLERGLAPDGAVSEQQMIMQVLSGSREEEEDDVRAAAEVRPPVTYYTTIPIIGDRQSMRRFDVSRLRELRKRLDSGSASQEDVDTITRDLMEDSADLSSDYIGNTVIQKLYERASPDLRRQMLERIAPHLAMIGIHKNGTWAAQKIIECATTDEEKDLITMNLRPFAPPLMCDSLGNYVCAGTLRFGAPYSDYVYDAMIDRMWDIAQNRFGARCMRTCLESPHTTLYQKKRIATSVILNSIPLATNPNGALLLTWLVEQSNLPGRYGLLANRFAPHVAHLCTHKLASLTVLRIINQTTEPAAATTLLQTIFHSPNDQILTEILGDASNGSQVIGKILAVSSISKEEKPKLLEAVRRVLPSIKAASTPPYRRLLEEVGLPIPQSSYQRSNSTGPASTQAVPMAAAGWQQGYQAQLGFAPVMNPGFPQPLAQTISPLLIPQNMALGQAMRAGSPPNGSAQPHTPRQGQRGRMSPISQMLSPGSDPFNPSPGMALPVRGNQSLSFDSQTNVGGLGILPNQPYYQQGGPGMYAQTGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR02</accession>
    <name>K1VR02_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR02"/>
    <dbReference type="STRING" id="1220162.K1VR02"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_678235_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR02"/>
    <dbReference type="OMA" id="ERVCATC"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="406" mass="43194" checksum="D8924A3D60AA9F8A" modified="2012-11-28" version="1">MPTESPAAPLQGSGGNGAGPSLPTPSSLKCTWCGAASSGQADGIIFLGQQMERVCATCMRTDQFELGGITTGLGLDLAGSSNLVAASPSSAFDFSRLRDAIRARGAASESKNEDGAASSSSPASPQEPTPAASVTPLVIPGSARAPASPTEETAAESPTLHSKSLPAARTAPWATANPTRNAHAVAPMTPAKRDTVEERASNPLLEVGSRGVPSTARGCLYPGSVFRGTQSSGRNSYDVQIQIADVNLNEYTLCGYLTIWKLTEAHPELTTYFDAEIIGPKYGFVTGPRYGAKEHDDMRHWGRFEEFRRPSTRADIVRPEQLLRDPLPDTSSGEIRPKEREFVFLRIKEKFLVPNHHDRDISGASFAANARLLLRYGGSVAYARASDAYLASAKIATLARPPPQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR84</accession>
    <name>K1VR84_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_03687</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR84"/>
    <dbReference type="FunCoup" id="K1VR84">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VR84"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_1"/>
    <dbReference type="InParanoid" id="K1VR84"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="130"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="253"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD01987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="396" mass="43506" checksum="82C6DCE507F72824" modified="2012-11-28" version="1">MTATTNGNGPNHHLAPGHFLFTSESVGEGHPDKICDQVSDAILDACLAEDPNSKVACETAAKTGMIMVFGEITTKAKIDYQKVIRDTIQKIGYDDSEKGFDYKTCNVLVAIEQQSPDIAQGLDHGDLENHGAGDQGIMFGYATDETPEYMPLTIMLAHKLNKAMADARRDGSMGWLRPDSKTQVTVEYKKDDNGHLHPLRVDTIVISTQHAEEITTEDLRQQIEEKIIKKVIPKDLLDENVVLHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYTARWIAKSLVAAGLAKRCLVQLSYAIGVAEPLSIFVDTYGTGKKTDLELVDIIRNNWDLRPGVIVKELDLQKPIYRQTAAYGHFGNPEYNWEKPKQLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRI9</accession>
    <name>K1VRI9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_02625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRI9"/>
    <dbReference type="eggNOG" id="ENOG502RE1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_4_0_1"/>
    <dbReference type="InParanoid" id="K1VRI9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="34574" checksum="D8A9E7A4FA673CD8" modified="2012-11-28" version="1">MAVKNLDTAADRSIAAVLGSAAGDALAIPYASSPDLLSKAPADQPLQVTSGGQWSQGEWASSTAMSIPVLQALSKDFSLGPGAPVEVPNFVAQEWLEWQKSGGKGGDDRLSKLFQATADEQSKSGGGVFPYGTAMTKLARQQGKSGNSDNNRAPARMTSLALGFLAPGQETALVKAAIALTDLTEPDQDAQEASALVALGIRNAILTGKLDLEKMTDFLPENRRETWKERIADGYKVDPEDFAKVNHSAIGAFKAAVAANAGADDVATAIDKATRGGGQSDRVAAIAGAWAGARFGSKSVPQWSSKLHGWPCKANDLQTLVSTVMNRYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRS6</accession>
    <name>K1VRS6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRS6"/>
    <dbReference type="STRING" id="1220162.K1VRS6"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306782_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRS6"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="570"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="895"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="833"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="953" mass="102453" checksum="69A7698529FD0A9E" modified="2012-11-28" version="1">MSSPSKIDRLDAAGSDAGTPKTSLDRSAKTPSPKPNASKVKGMAARWETKPDTAPAAKAKAQPKRLNARRPTISTASPRSGSPNALGSRPGPGLSSPGGKLSKSPISTSPNSFKSVDPKSFKPKNGNRLSGGSLSAKTNGTAMTRSGSTGATASDALAPSDADPASKSDTESFVSTLSPSNANTKLEPSPSIKSETPDTPTEFDSVPLNEDDLPGPERKPSNGSISPVKMSPSIVAATPVVEPAEVPSPDVELRAAATSGTDTDRLSSVASNGDSASPTTSLAPEPSPVKSAFNSLFGRVSPSISATSPTTTTTSEVKGKGKASEETVEETANGATTPKDAATKSESPVNENATGEGKPDTLKVETPKVSTFFASASKTFGGFSLPSVTLPTVARTSESAPDSASSDKASTPPVTSSVSSDNLTPADPLQHQPGHQKTGSHSAANWRTTMSNTMSSLLRGQSNVTPPPPIRTGSSSAAFILKQIDSPTSIRDRRISREAGGNTALREGFERVRNEMEGAARELRRDRAARGSSPGEEDEVDWTFWGAVVQDYEEVARTRPKELSRAIQQGIPPVIRGSIWQLMSSAKDTELEETYKALLKLTSPHEKAIHKDLARTFPNHQFFQGTGTGQESLFMVVKAYSLYDREMPDEEAFCVLVRLMDSYNLRSHYLAEMPGLQLRLYQFDRLVEDCLPLLHNHIVRKGIKSSMFATDVRFPLALVYRVFDIVLAEGTEAMFRFSLALLRRSEDELLKLNEFEDILHYLSGDLFEVYRAKEGEHVVDETEGQPTAAQGEWRTNDFVRDAYDARITPLMLDAYESEWTEKCRAQTAHLREVEALRSANRHLSAQVKSLEASVAAMNTEHVDLVKELVMAKIAREEMETELVKYKAMCAQLAQAQPGEITPPSRRSSDIPPPLPRKQSPRGSPLLSGMGSAMPNIKRVASALSQRSNTSNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRU7</accession>
    <name>K1VRU7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRU7"/>
    <dbReference type="HOGENOM" id="CLU_091800_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRU7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23186" checksum="7230EF1C9D247A32" modified="2012-11-28" version="1">MAPLNLLPAVPLQHPFSGTFAYPAEDFIALAEANMKPHPTFFNADDRRRIIYCVNAFTGRARLWYFEWARRKAGDHQRPADWYSVFKEDFLEQFCIPKIKTHDWLLRQLVHETSVGSYAEMFRKTALACREDVDSQYNRLWWVYGLRGPLQAKILDVFPLLDTYAELVEAAADHERFMLAGGDAPRTGRNGSLPVITTSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS73</accession>
    <name>K1VS73_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS73"/>
    <dbReference type="STRING" id="1220162.K1VS73"/>
    <dbReference type="eggNOG" id="ENOG502QVN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008537_1_0_1"/>
    <dbReference type="InParanoid" id="K1VS73"/>
    <dbReference type="OMA" id="GFDPSYH"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="882"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108809" checksum="62BBA450EFE61986" modified="2012-11-28" version="1">MSSSLKMLANLDPLPSDVRKWRILLLVSAVNSLTQRMQTYLADMGCTRVSTELALSDETMVSAVLAHSPHVIICPFLTKKVPDVVYSNIVTLIVHPGPPGDAGPAAIDWAIMGDRGFEPDSAAALAEMALPIDRALPLDQRQRTHWGLTVLQADHTFDGGPVWAWDQFPLPDISTVTKSNIYQGPITAAALRAVHVALCRISKAYAGLSDPSHRGQRVAVRPDPRYSKECVSNGQSFLGGPLNARPQIRPGQRRPDLTRHTAADVSRLINCGDSQPGGTIKTTRSFMFVYDAHIHMSVATLPKNLVQTRGFRSFDEVPAGTALATRQGAVLFKTAPCGHGPMCSHGCGIAVWLTHGRLPKPTPESALSAKVPMADALRAAGEGARLDGVPEWAVTDFTEVPGTWQQVFVRTVTEGDALIQLVYWDFYNGAFSTTGCDYLVEALMWATDPARGNVKILALMGGGYFSNGVALNIIESADHPGRETWANINAIDDVVEVLAGDVTSAPRSEFLGNRPSLTERGILTVACLRGNAAAGGVALAAACDVVVSAGSVVLNPAYRAMGLHGSEFHLYSYVERCGRSIATHLVKDMLPLSAARARELGLVDVVVSGRDQPAAESEAAILKFLRNVAAAPASAYGSLEFPSAPWTKFATNTPSRATTLVERFCENKRGRYESNLHVPLVNYRHEELSQMLLDSFHPHRSQRYHSRRIKFVRKVKAEKTPTRFAHHRVHMERDEEETAAFDNAPGWVRGEEWSWVGHQTPTSMTTSQGLLIDFAAPVPPLSRPPSRRSSRSNKSFHSLRSHKSQPSIRSHKSQPSIRSHASKGSISSAAPSVQGSPSQQHTATFAGPETVETLDDSVPPVPALPEVTTPEGVKRRPSLLASVSSGSIGRSSTWGRSTKNEPVAPEPTPAPYIPSHLAVKAPKRRASSFLGRLAGAFRSKQDLHVDVPPTPRTPLSATRIPSGATTPTYARPTLVNEGNTDSPCLFNITGDDALLPKIDTRPQVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSA3</accession>
    <name>K1VSA3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent RNA helicase fal1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_06163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSA3"/>
    <dbReference type="FunCoup" id="K1VSA3">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSA3"/>
    <dbReference type="eggNOG" id="KOG0328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="K1VSA3"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="49"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="230"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="402"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="458" mass="51791" checksum="D9440DE834D78CC6" modified="2012-11-28" version="1">MALTSRGDDKLVFESSETVQVAPTFEALKLREDLLRDFEKPSAIQQRAILPIIRGRDVIAQAQSGTGKTATFSISALQSLDLNNRDTQALILSPTRELAVQIQTVALALGDYMNVSCHACIGGTSVGEDIRKLEAGQQIVTGTPGRVFDMIRRRNLRTKDIKMLILDEADELLNKGFKDQIYDIYRYLPPATQVVVVSATLPHDVLEMTTKFMTEPVRILVKRDELTLEGIKQFFVAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTEKMREANFTVSSMHGEMVQKERDAIMAEFRSGQSRVLITTDVWARGIDVQQVSLVINYDLPNNRENYLHRIGRSGRFGRKGVAINFVTVEDVHILRDIEVYYATQIDEMPMNIQAGVDVRVQTIKRDSIRSPAGHCHPTDSRMTPASKLRAQPQPEAYGRSFKPLRPLPHANQSKEEIRSAVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT98</accession>
    <name>K1VT98_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT98"/>
    <dbReference type="HOGENOM" id="CLU_2962548_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT98"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="59" mass="6427" checksum="DD08258FDD41B06A" modified="2012-11-28" version="1">MVRQVGIGEVYLRIMHEASQGGGSAEPAMPDLPDIPETPVEEKPKPEQPQAKETKKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTG9</accession>
    <name>K1VTG9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTG9"/>
    <dbReference type="HOGENOM" id="CLU_888997_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTG9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="313" mass="33179" checksum="853781E323F28982" modified="2012-11-28" version="1">MVDYTPAPVHNQNNTSNSAATQVPRLRDNLEFLNEDVIATTSDGVPLHPRDARFMVKTEPNTPPRPVQAAPIEPNIKMEPDLDGQVRFAHLHPVAGAPDVALPRVRGHVTALAEPDLDGQVGFAHLHPVAGAPDVALHRAATPLAAHAEPALAGEPGIPQLDHAAAAARAAVPRVATPLADHAEPALAGEPGIPQLDPAGAAARPAVPRIPAHVGALATLGAPGRLASPALLPVNFQEPGNHIDNPIVLDSAPSSRAPSPVQPANVQEQLAQLHERNLQLQAELAQERHWSTVADRRIQRDRRIIRNVRKALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU44</accession>
    <name>K1VU44_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000235">
        <property type="protein sequence ID" value="EKD04056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU44"/>
    <dbReference type="HOGENOM" id="CLU_159503_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU44"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="102" mass="11234" checksum="39216A8C51DBEF16" modified="2012-11-28" version="1">MHAPLGVPERQQVEVVPFHRHVQRREAGAQPVSEEGGESTGRPAGAAGELKVTSIGPPPAWVDERLVRGSRNAVQRPTPRQEVRKHMRKDWEMAASGGKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUQ0</accession>
    <name>K1VUQ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUQ0"/>
    <dbReference type="HOGENOM" id="CLU_2028343_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUQ0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="122" mass="13448" checksum="26FD23DAA7AA0B83" modified="2012-11-28" version="1">MSTTAHSYRPISSSTLSSLPVDLTPSTSPKPKVAPPRKPTLAQRWESFIRVRQEYSLNMVRPSFFAPVPDARDARKSSTTSNGERGTKTQAQGQLPRSDMTMTTEARKLTKAKGKSKARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUV0</accession>
    <name>K1VUV0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUV0"/>
    <dbReference type="STRING" id="1220162.K1VUV0"/>
    <dbReference type="eggNOG" id="ENOG502S7VN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010591_6_1_1"/>
    <dbReference type="InParanoid" id="K1VUV0"/>
    <dbReference type="OMA" id="ADCSRTY"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854377" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="18048" checksum="AA69CD85F2C92138" modified="2012-11-28" version="1">MLAFVFSALPLLALVAADDVAPVDERCARTVIVEAGDTCDFISTKYGASTFQLSHVNPLSIDEACEQLQIGSELCLGFEGSDCSKIHTVVEGDTCGHLIDVYGMDDATLRQNNPQINDECTNIYIGEVLCVDTQAFEYPEFDQEKFEIVAETYLPFCDQVGEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVR6</accession>
    <name>K1VVR6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVR6"/>
    <dbReference type="HOGENOM" id="CLU_1653384_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVR6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="160" mass="17184" checksum="C067368D5D34950A" modified="2012-11-28" version="1">MLSASAHAAHAVRSSSPLNPRSSSPPPSSPTPGGYSSPARLPLFGRSNTTPLSARYRTTPSSSLASRRPGPGGRMPSSPGDFFSGDTTPTESAMWRDKFARRLADSQRRRSARDAEIARRRGTEPPPDLDDPDAEQRAMQEDEEVSTRGWPAGQPEAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVX0</accession>
    <name>K1VVX0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVX0"/>
    <dbReference type="STRING" id="1220162.K1VVX0"/>
    <dbReference type="eggNOG" id="ENOG502QQEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912739_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVX0"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="305" mass="32685" checksum="BAE7772D44571581" modified="2012-11-28" version="1">MTTQQLQQRDLLVLVWVHGLSGAHCAHSRGSPSGTERGVARLPGVPDKRRAVSRIVQSTREKDPLWPNVVATIAYDTPHQLSQAASYAETARSVAGNLAMLSPLALGWGFGKAKQAEDRAAEAESAKERSPAADPNAPATPAEKAGGWWSAKTAMGIGALAMGAAAAAGAYYREDLQNTFFTCLPPKPPLHPDERTFTILPPTSDPLRAFWRPQYNSKAKDEIGAHMGMFNPSSNDGFYDLGLQVSRLIARRLLDPEAADVPRTPPLEKSPAPEPAGPAKRARKTKAKANGAPDEKDIIDLTGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX35</accession>
    <name>K1VX35_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX35"/>
    <dbReference type="FunCoup" id="K1VX35">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX35"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010480_3_0_1"/>
    <dbReference type="InParanoid" id="K1VX35"/>
    <dbReference type="OMA" id="FKFEVAY"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="571"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="859"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="961" mass="106280" checksum="A42177B176B8B106" modified="2012-11-28" version="1">MEDGGGGGYGGGSSPYAQRAEGGGQQAAPADTYVQQSQPSQAQQQQQAYAAYAAATASGSGSGGNSEAQGSSNTGNQESTTGFVFPVHKGPIPTAAPIPQTAPPPARPAPASEPAALQSPFGGAANAHVHYPPQKMNINQHKGFQSVPLNDDPERGYAEELAQPQPHTYARKSKLGFIPLGPSRNNSVGSFGTSINEKESTAASPQQKQKRRLSSADWETFNSSTSKHKNLQFADGDFGKGAFAKFWLWALNRSFVFRWAIFIIPILAIFWIPGIIWAAGRRDAEVWNVKLLWWSIWLTIAWLGFWAAKLVCMAIPHIYKQTIVVIAPAAGKYTDVVRNLGKYFKYVLWSLAIWIAWNPIIINHCQRYVDGRLETYQDAAKANASLANATLLDNWGDAPETSGWSNISLAGKIIFGVWLCTLIQLAEKLIVQLIAFKFHEDSYADRIDEQKFQVKALTQLYMNSHDIPGRSDTLKDHDTIKTERSQAPKKAVRKALREVKKFAQNTSNAIGTVASEMTGSTTLQTNSPTNKVKAALQSANKSKALARRLFYSYRKPGSDHLVIDDIARFFPDLETAERAFGIFDRDGNGDATRDEIDASLLEIHTERLSLEASMRDLDGAVRRLDDILMCIVTVIWVLIFATMITQKISSLVSSASAALLSLSWVLGPTFQEVLGACIFLFVKHPYDVGDRVDIDTNQYTVVKMELMSSSFRRLDGKFVWIGHDVLRTKVIENIRRSGATSETFTFDVDFQTPFDKLQELRAVMLRFVKDNPRDYLPIFDVMVDDYNGQSKMTLKADIRYKSNWQQGALKVQRRNKWVCELKQALHNLEIWGPLGMGNPDRLLTDRVTMVPYDEYKESLLEQQAPSSPPPSFRAATAGKGLSGRHNEDTNLWGEVTYEDESRGPSRAPSPGPNSAFHIGTPPRVTSPGPSSTFRIGTPPIRGSSHQMPSAPGPAPYTQRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX72</accession>
    <name>K1VX72_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX72"/>
    <dbReference type="HOGENOM" id="CLU_1185757_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX72"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="234" mass="25681" checksum="16F616F46F09CEF3" modified="2012-11-28" version="1">MTLFQPPGSASCFMSQDATSQHNRVASPICTAHVSTIPCLTNGLYLEFGLVDESRVEQEQLAACQHYSPVDLLDILEPALARPSTALDAGDGPRAPPDHHIVPLAQLADLATAFEPFSILVEESTLNAHAVQNRDTSRKRLREYVAERGDVEREQEAETAHREAEHGRALALPEQRGGVQNRAVAAERQDEVRVWEQFVGCRPLVCALAPPRSTEPTNNDYVKVGMVADRVPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY70</accession>
    <name>K1VY70_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY70"/>
    <dbReference type="HOGENOM" id="CLU_1723623_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY70"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854109" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="162" mass="18178" checksum="75E3B05E70757078" modified="2012-11-28" version="1">MRTSIIAVLAGFASVHAELTGAYIQRKYGGMVRFLSPDGEPEEGTPVTLTDRDSAVTWRWDENDPGLLFPRVDGSDLCLSTTDEIVETGRQIVLAKCPSLPWEFSYFVSKAFRIKSRGLLYCVDVSGPNRTVVLKVCAGKYSDKTKYQDFIWQCPDDVEPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZC8</accession>
    <name>K1VZC8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine-uridine preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZC8"/>
    <dbReference type="FunCoup" id="K1VZC8">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZC8"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_2_0_1"/>
    <dbReference type="InParanoid" id="K1VZC8"/>
    <dbReference type="OMA" id="PNIKPFC"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="33290" checksum="32F940B9C9921129" modified="2012-11-28" version="1">MTTKTPIIIDCDPGHDDALAILLAAGTPSLDVLAITTVAGNQTLDNVTRNASSVATLGGLTCPIARGASCPLVRDPIVADVHGLTGLDGPEPGDMPAPREAIETPACDLIADLVLSRPGEITICALGPLTNIAMALRRRPELIKAIKAIYLMGGSVGSGNVTPAAEFNIFVDPEAARVVFRSGVPVVMVPLEVTHRALATDQVITDIAALNTRLSNALVKILGFFKEAYLRTQGFGSPPIHDPCAVMALIHPEIIKVTRAHIDIETTGGLTTGQTVVDRRAPAPEDCTTAFASDIDVDAFWAKMLEALKRIGEPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZH1</accession>
    <name>K1VZH1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcium activated cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZH1"/>
    <dbReference type="STRING" id="1220162.K1VZH1"/>
    <dbReference type="eggNOG" id="ENOG502QTER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014123_1_0_1"/>
    <dbReference type="InParanoid" id="K1VZH1"/>
    <dbReference type="OMA" id="YQKCIKY"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="2">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="250"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="608" mass="68860" checksum="6C2958A81CE65164" modified="2012-11-28" version="1">MLAQTPSTRLRALTLRLLPQEVEDEEITSASSSIVSPEVVEIFEEAGGDFREAIPFCLLRARKMFVEDANANPTDYGENMCRATACEVLARRSVHRMPPHRLQSVMSTRYRYRERDGDASAPTCALETAIDQHCTIFLSSSEAQMVVTMLWTGKWVQHNNENDDIDYVEYVPPHDNPHSFWAHMDPSRLGVPRYQTWFRIIVWIFFLYVYSQTVQSPVDSVDPLRQFDAWEIILYTMTFAFFLEEIVKITKNFWNIVNFITAALLLTSLGLRIAGINQPADSKQRAHLHLLSFQFLACAAPPIWLRLLVVLEGFKVVGVLQVVVFRMLRESAIFFILLAIMGVGFAQSLYALDAADGDTGDDGSSMWLIINSLIQSLLGGADFDTASQRFGYPFGLIIFYFWNFFAIIILVNVLIALFGTAYSEVYDNAVDEFITFFSGKTVDMIRAPDSFVYPAPFNLIEAFLVAPWEFCLTKSQYVALNRFVMRIVFCVPLTMIALFESQIMHSHGGVGGMIHDYFAEPIPEDDEDPDVLDPKGDDEGEISTVKFEDLAKRLPNYFLNERQLTSSTTVSNSSLILGELKKMKGNLDTFEKQVRSGNLDVKVEEVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZU9</accession>
    <name>K1VZU9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZU9"/>
    <dbReference type="eggNOG" id="ENOG502RB5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_667631_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZU9"/>
    <dbReference type="OMA" id="MNTTHSH"/>
    <dbReference type="OrthoDB" id="2576031at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="416" mass="45563" checksum="0DF409867120CA2B" modified="2012-11-28" version="1">MSDHEDLVDYGLEDESPDQDMESVSGMAEQVSTSTIGTIALPTETEVLLAERVAELERERDALTARVKELERPNSSAADENVPISIPPALVPVLALLRQHIRELTRENSALRYTFLGSHTPARQEVISLSVGATPPTTGDVSPATPLEPMSAGRTPLMDHKAVSTAPDVDLEAVLTRVKTLMLENDELGDLVAETGQASSDEWLKALEDSRAVIASLDSDLNENLTVVEKLRAELDGYKARFGSLDAHGHPHGQGQSQSHGQSHHDGRQRGGRGGGGARGDTRDVDRRNNGRRDGRDGYRPNHDDAHARDTRDGGRERNDRNDRNDRGDRDRGQARDGRDGQGRDGHRDGRDGPTANHRGGDRGDRSDRGERSDRSDRRWKDGPNANHRGGGDAGLQILGRATQDAKDDRAYKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0Q3</accession>
    <name>K1W0Q3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000092">
        <property type="protein sequence ID" value="EKD05402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0Q3"/>
    <dbReference type="STRING" id="1220162.K1W0Q3"/>
    <dbReference type="eggNOG" id="ENOG502RB54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018729_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0Q3"/>
    <dbReference type="OMA" id="EWTYSER"/>
    <dbReference type="OrthoDB" id="2564751at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="474" mass="50741" checksum="439807082FAA8529" modified="2012-11-28" version="1">MPGHDYTDSEPEIDPDELIRDIDNDNDDAEHGVATPTTQASAASPTKEPKSKDSNQSLKITLRPGRASSSAAADEGSSSPAPQSIKLKLGMKHSIASYSSSEDEGNGDKERSPPAKKQRTSKKSRASPSKDSKDGKETSTGPSLPAPHRKAYDWLPSSAAGASHHGPEGRNHLKDDDVISDAGTDTPAPEKEVKPKKGGRKRAPDAPPGPGKNWRKGMRKGDPIPWKDGATFLGGEGRPKSSPLSTPNRPSLSRDVSPESIDDTILAVATGSTKRKAHVDDRARSPSPPFVLADAAKLGFPVFSKPIHQPKIALSSFPKVTNSFAQFDNKPFRKEKVREWTYSERTLPGIGGGTLKFKTWSRGPQSEFGVIAAQMKEAELLAKQRKKEAKEAENREGSAVAAERPLFGHSQSSESVPQVGDDSEIVSEAGDADESVVSIASASSTPTPTMRGRGKKAKPRKSKLAQEIVPDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1W145</accession>
    <name>K1W145_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_02933</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W145"/>
    <dbReference type="FunCoup" id="K1W145">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W145"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="InParanoid" id="K1W145"/>
    <dbReference type="OMA" id="KVCIETM"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="105"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="320"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD02703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="427" mass="47799" checksum="18E30E12A5318F69" modified="2012-11-28" version="1">MSTQVAKTPAGLEKIKAKNPVVEMDGDEMTRIIWEKIRNELILPYVDVDLKYYDLGMENRDATDDKVTVESAEATLKYKVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIILKDLPKPVPGWTKPIIIGRHAFGDQYRSTDMVVPGAGTLTLKFQPENGGEPIELNVFDFKGKGVAMSMYNTDESIEGFAHASFKMAIEKKMPLYMSTKNTILKAYDGRFKDIFAEIYEKDYKQTFEKLGIWYEHRLIDDMVAQAIKSDGGFVWACKNYDGDVMSDVLAQGFGSLGMMTSELITPDGGILEAEAAHGTVTRHYRQHQKGEETSTNPVASIFAWTRGLAFRAKLDNTPELAAFAKDLEDACVEVINGGVMTKDLALAMKGKAMKREDWVTTTVYMDKVNELLQKKLLARAPKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1F8</accession>
    <name>K1W1F8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000275">
        <property type="protein sequence ID" value="EKD02833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1F8"/>
    <dbReference type="FunCoup" id="K1W1F8">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W1F8"/>
    <dbReference type="eggNOG" id="ENOG502RDGX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_0_1_1"/>
    <dbReference type="InParanoid" id="K1W1F8"/>
    <dbReference type="OMA" id="GAKTHYL"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="99" mass="10916" checksum="6778B7524305DABE" modified="2012-11-28" version="1">MFPTLARMNAAAPGAKTHYLIRLVRSPIGLPARSKANLEALGLYRLHQKVLQKHDVTAAGKILKVKELVVVENVEYEEGLKALARRRPEGSGVEVIGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1K8</accession>
    <name>K1W1K8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000048">
        <property type="protein sequence ID" value="EKD05642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1K8"/>
    <dbReference type="STRING" id="1220162.K1W1K8"/>
    <dbReference type="HOGENOM" id="CLU_912730_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1K8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="305" mass="32971" checksum="36FEE44AD73ECD64" modified="2012-11-28" version="1">MQRFHSAPGMPMNHSWSNPDPFKCSTPGFEQRPPQQQPPSVQPRRSEDANSTQWDENADGQTMSRENSANGNDDASSSKDANEPAQQSKVEWGQAPSYPNVSGVVPRGSIRMSSAASTASTTSSLMNVTQTPQGLPPISIFPLGGQAGQFNNLSFPMGHQWQQPLQKPEAMTPTVIGKPMFGNPHMEEQLDEQTITLGSPVQHKDPSQRDRQVSGVSAVGLGIANVTFDESGLDVKEEQWAPSEIGTDGEDELESEEDDEDNDSDDDFMPGANGKKRGATTTGAKRGRGRSVLGRPALKQRRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3I1</accession>
    <name>K1W3I1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3I1"/>
    <dbReference type="FunCoup" id="K1W3I1">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W3I1"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_12_2_1"/>
    <dbReference type="InParanoid" id="K1W3I1"/>
    <dbReference type="OMA" id="FNQDMQM"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="88"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="25708" checksum="0DE8F363C0E7CD88" modified="2012-11-28" version="1">MSKKTFPASPGARRSSLECWKATAWALGRLRVPKPRYGFVPKAAGDLCVRASGVLPGRAKHRAARPESSGPHFPGSSILTICDCTNPSSNQPSGRITFKLFDDVVPKTAANFRALCTGEKGFGYAGSGFHRVIPDFMLQGGDFTRHNGTGGKSIYGEKFADENFKLRHDRPFLLSMANAGPNTNGSQFFITTVPTSWLDGKHVVFGEVTSGQDLVKKIESLGSQSGKPKADIKIAASGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3P8</accession>
    <name>K1W3P8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_02236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W3P8"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="InParanoid" id="K1W3P8"/>
    <dbReference type="OMA" id="CMVPDGL"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="846"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="933"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="225"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="505"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="808"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="485"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1384" mass="153359" checksum="089AFED887352191" modified="2012-11-28" version="1">MTAGATEKVELKALDTGDKPAEPHTTNTKPSGVQDEKGPGDDKSDSDSDTAQEDEVAFRLRELANEEEDRFKGLKREHWWQIWRSKHGPPPPRKSLDEAPDLPLATANIFSVLSFHATDLWKMDPSRESDHLSNRFLGYLHQSQTKADEWNRAHPDPRPKRRSRLGWKIKAATKRRLPPQYAKFGPDKSYRERVRTQAAHWKAHSRKHGNLALALFKTFPTYWYAGLFKVLADMTQLMSPLVIKALIRFSQQVYAANHGDGIKPNIGRGVGMAIGLFCLTLMQSVCQHQFFFRSMETGALARAALISATYKQGLKLSVGARSQHPNGKLMAYLSSDIGPSALVGFAVFVLLAPVQTNFMKTSFREMKGIRIIHLVRTANQAVATSVPAIAAVLAFVTYTSYHDSLDPALIFTSLAYFNYLRQPLMMFPRALSSLTDAQTAIERLTDFFEAETMDVSNPIDHNLDVAVRANDATFQWATVRAPDELSEKAAGKPGKGKKGRKGVKEEKEDASPSSTEKKPEEEPFKIANLNMEIPRGRLVAIVGPVGSGKSSILQGMRKLGGSVTFGGVLGYCQQSAWIQNATLRDNIVFGQKWNEARYWQCIRSASLITDLEILPDGDLTEIGEKGVNLSGGQKQRVNIARALYFDADIVLFDDPLSAVDAHVGKALFNDAILGLKRAGKTVVLVTHALHFLPQVDYVYTVEHGKIVEEGTYDALVARGGAFSALMADFGGSAAVKEEKEDAAEEKAIEEAADMETDEQKLARLAAEDVKKAAGTGKLEGRLMVSEVRKTGSVERKVYAAYLKAGKGWITLPLLLIAATLMQASQVLSTVWITYWEVDKFHRSMGFYQGIYAMFGCSQAIFTFAMGSALGMLCYYASNTLFRSALRRVFFAPMSFFDTQPLGRIMGVFGKDIDTVDTTLAEALRMQTMTLAMLLGSVIIITVYFHYFIAIIFGVGCGYWYFAQFYRTSAREVKRLDSMLRSLLYAHFSESLSGLATIRAYGETKRFIHDNAYYMDLEDRAYVLTYSNQRWLAIRLDLLGALLVFAVAIMCAAGGGGLQPSEIALCLTYMTQITQMFGMVTRQSAEVENAMNAVERLAYYSDGSLPQEAEYEVKETEPPAEWPQAGSIELDKVVMSYRPGLPPVLKGLSAQFKHGEKVGIIGRTGAGKTSITVALFRLAELTSGRILVDGVDISTLGLKTLRSHVAIIPQDPVLFSGTLRSNLDPFDEHDDAALYDALQRASLIDSAEGHGRWTLDMAIDEEGANLSVGERSLVSLARALVKDARIVVLDEATAAVDLGTDAKIQRTIRREFGGKTLLCIAHRLRTIISWDRILVMNAGEIEDFDTPLNLFDREGLFRSMCDRSNITREEIVHARQEERFDGEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3R3</accession>
    <name>K1W3R3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RB6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006330_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3R3"/>
    <dbReference type="OMA" id="EMRRIEW"/>
    <dbReference type="OrthoDB" id="2596830at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1363" mass="149215" checksum="98ADDB9262BB2EED" modified="2012-11-28" version="1">MPSTVRSPEDGSAAQPAASLHATTLAKLNGNGQAGAVNGSPHSGGQGVSGPEFPELKAPRPKYATAAPPNIFVPRLNRPYDEQHEASTRESTPQSSPLESKFSPPASGRPSTSSSPSTTSRRDRVAQLGGSPSGSPLARNDGFPSDNVRMPARRSTTSDRNRPSTLAPIQPCRHTSLQYGRRPTLVTGGYESSTDEDDPAQALGTGARSPTRRLTITPTRSNSTASSAHAAHGHGAYVPSPPQNSRTVSGTLSLPHQQLASSSSRRRAQSLISPALADQSAPPTPRRQSRLRSSVGLGSPMSTRGAGTGSSPRLDGGAFAPRVDGPTLRDTRSGSLRGFRDAVQEEPERERSPATSNTEKRRSKRHSHHGNPLTASLGLGQSPQQQILSPDQLQDLLGNADLASALQLMSPPAPAPATRGIPAVFPTAHEPPQPAHDSESELPEDATVTSPLKPFLVSAPPALTNGEWPGRPRAPSTASSFMGPSSFGTHGPGRFAGPRHRTVSASTSVDSDGFPQAPSSQLQSDDNIDECREEEEQQDDSVYVVPEADEAPHHQQPPTHDRTAAHMPASAEEGVSETTRTVRPTHSKERNRISSFFGLRKKDKVPSSPPASAGAQPATLPGPSSNPPQQFEAAAVQRRIDPEEEMRRAEQQRREEELAQERRYKALMQIHAHPAASRRAQKVSTHLDAYYSLIYDGINNPPKMNPLAVLRWKKRNNDQKEARAKWEAENLKPPSVGTSASPSRPGHISRNSFSSSYNRALSPRPSGGIAEEEARVAPGWYYSLNDVVAYNACGGRVDFFIPPAPPAEEPKRDDGVRSADLSMSVKSSQSHDGRSHRPSFGSDDRGRDLPYIPNMVSEPPRPSSSSLILGPDNHYLSQEDLTQPPTPDRSRGGSVDHGTHQQVQQHQHQQQHQRHRHAHSMSGAAQPSTLQALRAFPKHLGNTALAKLSSAVDGPDEYGSKRLASESPGLSSKGHNRSQSLAHNHPRTRDRIRNKFGNMRSTNDNNATTGTSEDEPHHLRKLIARGQRRVEEWAQRPNSADNGDQIYLEQRNLEETLRRERENRERQMKRRPTIVEQEAEKRLGELDEALFVQKDDELKMARQRLIQLDDGEEQMETSVAHYLAQLGQVTAMFASAADVDVRFDNLPPAPKLSPLDDDEDEDETADELYPLRSDSETGYRHPFRPRRQGTLPPNNLPVFAMGMQAAWPKRSVVDPVLCEPLDPIKRLELSCDKARAVQKDMANSRVNATKALDQMVETVNQLIRQKDIIRNWVKNQLDVIQGLKDEKANVQLKIRGGIKPRLWTWRFQDVAIDAGARTVMSFLSYLIRTYNFGRKIMSAGWLGWAVIVAGIAMVGFFYYVGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4H0</accession>
    <name>K1W4H0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4H0"/>
    <dbReference type="STRING" id="1220162.K1W4H0"/>
    <dbReference type="eggNOG" id="KOG4776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915325_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4H0"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="190"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="270" mass="29280" checksum="4938E7AB92FA18C0" modified="2012-11-28" version="1">MSTLATADLGPSDDEADTDFVPEGPKKKAPRVAGQAAGSDDDSGDDSDDEGGAEEVSDELKKLRQEREEQEALDRKQRAAEAFRAMLEEEKLGGPLGGVPRVQVEMVEIQRPRRFAGETIYETVCLPSDDPEVIRYLQQQEQKRLASEMSPSGSGSVTPTHNGNGHTEAAAAIAATESPSKPPLRKGPMRKRPRQSLEAMAAAIDKGKKMTTLEKMDWKSLTSSDKHLADELQANRRSGGYLEKQAFLERVSERKESSAPGSASSGSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4J2</accession>
    <name>K1W4J2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_01801</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4J2"/>
    <dbReference type="FunCoup" id="K1W4J2">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4J2"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033366_5_1_1"/>
    <dbReference type="InParanoid" id="K1W4J2"/>
    <dbReference type="OMA" id="QPWKENI"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="192"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD03788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="423" mass="46830" checksum="387B82D99621AC7E" modified="2012-11-28" version="1">MPLPKGPAPVLPATGLHSFHNDSPPFAGTANAEHPHPPALSLEEAAYLQTSALDDDAELSSRRSRRLVTGYRLGNPPDSPNNARVAGGLDDDAVSRDSDSPPLTVNSELEDDLITPGVPRGAVPTQGRRRSERASGFDLAGLHDGEADADHRAPRAPVESAAYLRGESDYSFPRHRLRRTMKDEGKIPLVIVACGSFSPPTYLHLRMFEMAKDEIVESQTYEIMAGYYSPVSSYYKKSGLAPALDRVRMCELAVEHTSTWLMVDPWEAGQGEYQRTAVVLDHFDEMLNGPNGEGGVEMADGTRRKYKIMLLAGGDLIESFGEPGVWAEPDLHHILGGYGCLIVERTGSDVWSFLLSHDILYHHRRNVIVVKQLIYNDISSSKVRLFVRRGMSIKYLLPNSVIQYIHDKKLYRESDARATLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6A7</accession>
    <name>K1W6A7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6A7"/>
    <dbReference type="HOGENOM" id="CLU_577709_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6A7"/>
    <dbReference type="OrthoDB" id="10684093at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="442" mass="49870" checksum="BC9C265F97A93391" modified="2012-11-28" version="1">MPTPQPPRTRRQQEREAESLAHLRKDFRYAPQRLYSPFTAGCSHTFPIADFTEAHYKQDDTSLNKTLWSLWPVAPPDGYKKVLAHQEAKRDELTFDGEKDPSEPGWFDHTRLPAVLPHAERFRIASMVRLIQELHVRLNGAGWLQFDTLADGVSPMSLLQTRQMMLDVAPLSKAVDTAKKIKKEAHDLLKVDHDYENEDVLALFGAGIGKQCSALFALWPWTASGLLMTPDVAFGTGIAQLQLWLDISYACFFLKGHAKRESGRLPNGTPYEDTEGYYFVILGRLANFIPIHTRYVPFGVLQQAIHHISVFPLMISTLQELWGPEMMEALILSVRCSTGAGLTPNAWAHADCDASHRGCMGIGYSQETRLESVASIVKLRDERVTRKEQLLEECRLAEAKDSDGESEGDESKGESEWTYDKKGRKKFGPKEEYSIRGCVNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8S9</accession>
    <name>K1W8S9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8S9"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250515_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8S9"/>
    <dbReference type="OMA" id="HHESRVE"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1465" mass="155958" checksum="88D0A56EDE5AE479" modified="2012-11-28" version="1">MEMDMDISWCLACSRRTRDPSNPYCSESCRLSDAEPSTPLNERQLITSPLPPNFVPLPPSPNVSRKSSDRRPSRRAAPNSDVRPSLSPLVNRQAPSTGAIHDLNQQEQRKARDRRALSFPAECEPCPEEEETNRALAFVRKTKPVNGVSRSFKRRSLQMSPEISRLTMTTGQVTPSTPTTPAVETSTFYSTSDSEDGSANGQRSPALTSTQLHPAPPMPLTRMNGSSNTSSHRDNGVNVASSLSAKLPGRPTLEARNRSNPVTRMSSSSSRSREDIISWARGVDARHRTDDGTPVDTATIRRSRGRRPEAFANLVPPSTEPLDEPVTSTTPKNAGPLSALSMTFGPVMNAFRSVSGGTAPSPTAPAQNPIPQTSALGLQAVPAPAEVSIVDVVVGTKSDCQSAMDPSTPSLSTMSLSDAVDPSTTTDMCDTATDDFSIVSSISRPPIYTAPSTHNPLPQQFRRANKAALPLRPTIQSTASALWNFSTYIRSLTPFAAPTTPKPSSAEPTPQLTEDTPASESVLLTPDSAVQATSPVPTTVGRPESPDFTMQPEQLVRSVPMDIAIAPGSKALEVIQERQREREMLENMPRSRSRTRIMASRSPSVEAQIGRKHHTRQVSYDADCSEVGGGDDRGRRGRSRGRAPRGERRARTQPVTPPEPVAKAAAVEEEPERGRRRDRGAESRDPPTPAFQEAVDRTKARSPITRSERRHHESRVEMMAQEVGSGASDPQQAASGQKKKEVGGDSHEEREPRESASRDGAVMSAATAQASPSRLNLEPAPQPSKASESGESAGGAERQGCQEAAVVGLAGPDTGDAGILPQLPSGMSRQEGQGHSAKIASSSTDEVVTRPPPLSILAAPTEDSGGAEAAATHAAHAARATLAAQHSDAGDEGHEGHEGLGASAADEEKFEVVGGLGAAADSEFEEHKGNGGNGGNEVSTPALIHPHQVSGSDHPASAVPDEGRDTQNGQVAVTANPAKDEMDVDDDPVATKEAGKTKPAMFAYANTGAPPSAPRAPRGLASLPARPSAPSFRTRAPLPSQNDSYATVFGAPAPTRNRRDNHSSHNDSGKEGPRGVDRSALSSLIFSISTTPSAASELLQLPLPSRRQTRRATGAGVLIPVERLPLLPLPPLPPILDKKLEKVVFSHQSLFPRDAGVFEYPVKVIGEGGMGEWEGGVPHYEKLEHVGDAILGGVVTTWLHRCWPGLTCGTATKLKAHLVSNNTLSHLSGMYHLPARLACAPLLRVQTDIRAALVEAYIAGVYFSHPPGAGIGIVTEWLEEMYAPLADFFLQHMRGEYAVLRATVGTSEGRVVTHRGHTSSIPANPSLAVPDTVPDTVPAESSSEDKGGDRSGADDGSPSQLKINAKPGRRGTVSQPDALEAADERLRPALTALSAYCKETRTTLEFREKRFRLSSGTLWKISVVVGGAERGEGMRVTKYRARWVAAAQACAELGIGWEPEEVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8X2</accession>
    <name>K1W8X2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8X2"/>
    <dbReference type="HOGENOM" id="CLU_891947_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8X2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="35837" checksum="C2CA4EAFB3DDC204" modified="2012-11-28" version="1">MPVITPPDAELNLSQDGWKMVINLPPGAAVSVTRDAASSSVGSPAAARESSRIAKRTFDELYGTPVPTQQLVGLHHGVHYGVAALQKNLEAMWPTEGDGHRDDDGDVDVCLCHCAKEVDFAAVLPGERDEASDAEPDDYADESDMDDDEVAAEAPLLWTENVTPRPAVLHPSTLSCFYSERELGVLKEAFEILNGDVGEPDLVTTQGNTWAIEAREKEEGEREAKRCRTEGAAERINVEAADSQDVDMKDAKTSQETPEGTKPQSTVSKCSQYTPWSFVSDEEPVEVRTPLPPSPHPDYEDCVFDPAQSPTGGNRSENDSDGSRGIWIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9F9</accession>
    <name>K1W9F9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9F9"/>
    <dbReference type="HOGENOM" id="CLU_631913_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9F9"/>
    <dbReference type="OrthoDB" id="10685437at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="434" mass="48281" checksum="0130BEB44812EBEA" modified="2012-11-28" version="1">MTIQTSFSYDNFPNLWDEILSHASTEAKRDVRTVSRALRSAIDRRVRHLILTAGPPPQSEEDLDVADGAEAAAYDWRTGLTMPTFPVLQRIGAWGSEDDSFNCWGSNFDIVVPPWREQRALTRLTGIVDFFGYIHQWLHLGRISHLFTHLEVLRLTQDADGTFLFYLPFGADTVVLFPSPKGLEANMANPICKGLSGGRNRAEEPSILDAFWPEPPQPSELLVSMLPEAEPEMNPPLDVPRGIPFGVHRLVVNLDGHIGNPATSFHFLYDIPEHVAEIVFVLPHLTSLSGTGSVKGASAVDLVEVMRSSTARHTVVGCECVGVANFADEVREALKALTVHEPHLDVDYSIDDELTCGMSGWQRKSVASRAHALSHDIVFWGDHLTVPVPQEKTLSLKQKVDDRLSRLEFVTVEEYRRRVGEEAAALHLIQYPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9I4</accession>
    <name>K1W9I4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9I4"/>
    <dbReference type="FunCoup" id="K1W9I4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9I4"/>
    <dbReference type="eggNOG" id="ENOG502QU0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010459_1_0_1"/>
    <dbReference type="InParanoid" id="K1W9I4"/>
    <dbReference type="OMA" id="AQYMSPT"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="95"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="187"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="567"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="655"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="808"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="953" mass="110158" checksum="01918514F91738F3" modified="2012-11-28" version="1">MTPLSKEAPAALLSLSPPPSVVPERRQGRGRKDDDSESEGEALDAKYGGHSEDDLSASFTAHRERLDKSLTKSKRTGAGAGRHSVATGNAGNQMTLREQEQKENFNLQLENHFLKERLASMAPDHIESALKENVKLKIEILNLGKELKKSKKLLVQQDRDLAAAARERDGHKVKARDAESRELEAMWREEKERRIAAEDELDKLKDDQFDRAQELEDRVRNLEEELERAKDDLDTARAGLDDQNEEIARLRDEADRAVDELEKLQSERDLGESVGLGKGREARLVSKLEEEVETLKVELEDARAATADIEELEEQINQLRDKYAASQIDLERRDEEILDLNNEMDLRVREHEREINQVEAEWRDEVLETRGQVDELKDVMQEREAEIEDLRKGLLEREDELAGAREQIMVLEAAQGETHDRLEETLRGIQIDNEEKEADLLEANREVESLGQRVYELEELVDELRAREGELAAELQRMDDEKENYDELVTALKEARRKIQDERDDYASRLARAEEAFHSEREAWEKSRQREAEHHERVLATKDQVTERLTTELEAARDRVAMRDRDLVSVQNALRSLEAERRKLGDELSSDQRSLELEIERLRRDLARAEDDLDRAREEARERESSLAKRDMQLAELMDKHRSVERQLTDERQGRLQLSDKLDAVTKTARQHEREAETLRSRIEDIEPLLTESRNSRALLQRQNDQQRQERTDLLLRVFKDVNRFLAVEDSTTPANFTLFKDTLLSRLRSISGVRTDFDKRIRETEARMESKMASLKRQLEGKWRALDGFEASVKKLELARAQWRARLASKDGELESARGQISDLKRQLSSASSSRSPSDETIKLLTDRASMAEKRATQAAQSLESLERKFEELQKRTGSADTKWEARVKEYENRLRIAGEKVKAEKQGGKERAQQLETQVKELERQLELTRRHNRRAEGVVANAAHLLKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAA6</accession>
    <name>K1WAA6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000005">
        <property type="protein sequence ID" value="EKD05693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAA6"/>
    <dbReference type="STRING" id="1220162.K1WAA6"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_3_0_1"/>
    <dbReference type="InParanoid" id="K1WAA6"/>
    <dbReference type="OMA" id="ATETHHN"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="7"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="451" mass="51664" checksum="F7DAC3AF7D89318C" modified="2012-11-28" version="1">MGYEGRTISNVPVLDEILKIRRQIADLMGFETYADFILDVKMAKNSKTALDFLYDLKDKLTPIGEAEKKVFLQMKKEEHAKRGLDFDNELYLWDYRYYDRLWTEQKLGLDDEKVKEYFPVNKVVPTILDIYRKLLSVNFYPIPKDSPEGKFWHDDVQGYAVWDHQDGKDGDFLGFMYLDLFPRENKYGHAAVWGLIPGFTKEDGERSYPVVCMVANLAKPTPNRPALMKHSDVVTFFHEMGHAFHGLCSKTQIPRFHGTSVARDFVEAPSQMLENWCFIPEQLKEMSEHYETGEHLPDDLIEGIVKSKNANLGLFNLRQLFLGIFDMTMHTSKEDLDLSKLWCETREKVSLVSTDGEVVGGQSAFGHIAGGYEAGYYGYLYSQVFAADMFETVFRADPMSPASGMKYRDSILKPGGSREEMDSLKEFLGREPNNEAFLKQLLSGAEPEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBB1</accession>
    <name>K1WBB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Ras-related protein Rab-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBB1"/>
    <dbReference type="STRING" id="1220162.K1WBB1"/>
    <dbReference type="eggNOG" id="KOG0080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_7_1"/>
    <dbReference type="InParanoid" id="K1WBB1"/>
    <dbReference type="OMA" id="VYDVSCQ"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001312">
        <property type="entry name" value="Ras-related protein Rab-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="222" mass="24951" checksum="AA56FA09F80FD7E8" modified="2012-11-28" version="1">MSADPSPQPPSNLKLLLIGNSSVGKSSLLLRFTDDDFLSEEETAATIGVDFKVKSVEVDGRRYKLSIWDTAGQERFRTLTSSYYRGAQGVILVYDVSQRNTFDELIKWFREIETYCAEDVVKIIVGNKVDKVTLVAMRRADESQEFTRQVTTEEGQAFADRMGTLFMECSAKTRVGVNDAFQELVRRILETPSLWTRGPQPVRTPNVQLQEDAPGYLSGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFB2</accession>
    <name>K1WFB2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase zeta catalytic subunit</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">A1Q2_05426</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 26">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFB2"/>
    <dbReference type="STRING" id="1220162.K1WFB2"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_4_1_1"/>
    <dbReference type="InParanoid" id="K1WFB2"/>
    <dbReference type="OMA" id="NAQYYIT"/>
    <dbReference type="OrthoDB" id="2590015at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="10"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="465"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EKD00249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="564" mass="62618" checksum="B151C11E3AA64FED" modified="2012-11-28" version="1">MVTPSKQQVGLQNAPFAVPLIHEPESKYYNHPIIVLDFQSLYPSVMIAYNICYSTCLGRVEQFKGTNKFGFTELKVPDGLLELLKDYLTVTPNGMIFVKPAVRKSLLAKMLGEILDTRVMVKQAMKGYRDNKSLTQMLNARQLGLKLMANVTYGYTSATYSGRMPCIEIADSIVQTGRETLEKAQELINSEAKWGATVVYGDTDSLFVALPGRSKDEAFKIGHDIADAVTAMNPKPVKLKFEKVYMGSVLMAKKRYVGFKYEHPDDVDPVFDAKGIETIRRDGFPAQQKIEEIALKMLFKNQDLSEIKAFVQDEWRKVLTGRVSLQDFIVAKEVRLGTYSEKGVPPPGAAVAYRRILKDPRDEVEYGERVPYIISDSSTGGKRLIDKARTPEEMLSSNLGIDKEYYIRNLLIPPLSRIFNLVGADVEQWYDSMPRSKRVSTYGANGGGGSARTTRIDAHFRSRHCLVCGAESGDALCAACRDEPAATAHALLSRQHAAHSRLAELQRICASCAGTGPAERVLCDSIDCSALYARARAEKDVTDVADVPALVAELDQQDTLDLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHK6</accession>
    <name>K1WHK6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WHK6"/>
    <dbReference type="eggNOG" id="KOG1992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253988_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHK6"/>
    <dbReference type="OMA" id="CIREMAT"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-2 central" evidence="2">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="3">
        <location>
            <begin position="829"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1406" mass="158273" checksum="74A6488348BEA8AC" modified="2012-11-28" version="1">MANFETEVTSIVQGYITTFLGQYAQNPQANWKSKDTAIYLLTSIASRGSTVQADLAPTPTRKTPARGRKRANVDLLSAPSTPIDTPTKRPRRGRSAKEPEPEPPAESQLPAPAEVQQTSESVAAEAAPEEAMEELAAPVEASEPTPAPSTSETPGPRKTWAVGNPPEPEEPMAPEPEAHATPLSQGDSQIDEIMTEDSRQATVDFEDEDEPLVAIEEKKPYTRSRGPRVDVSVFRRTNEIFQCLSDMGGISTDQRLHHEIGPWAQKWAGTDHPNAPAVASGMDRKVFKRILNRLIEDGRAKMRVATMPTSTGRWVRQSVVYLADTPEDTVQDFVRKLMAAPLPGVTQVSAGRNKPAIEYSAFKRRPPTHVKKSESEDPGRPLSMRERLLTDSTVVGSMYNYQFGRCVRTRTLHQSLVEAFAAHPEADSVVSTSPRVFALPFLFEYIRIKDFFHIVQHREYDEVLYEWLQDPANLELRINELPEDIAARCNVGSKTSTSSKQLIRTLLGTLDFLNIVMPLQVTDKASATLKLDGASRDHPQYFKHHDDINATTYFMLYDVAPVWHIADPSLSLVGFMPAATTEDMKPLWDAIQSASVDSIQPHVQRMPKMPSFPFAPQVHGVLMGTYKEIDMCKTLRSRVHWKDDVRVNIEQARALRAERVKGKTHTDEELNQLAYDLCLRKNDLVNLLVRKERARLPPRGAPPRERRGKETYRNEDERDAIREELAQRIKAAREVFEERLATAAERANVELTDEVRKYVAANRPMSHLGAMVSEEDLMAVIYSYQRHKQGVLPSRRNKLTARSARPSVPRPDRARKSSSLRDSSSSKIRRHRHNWSRDEEELFFDAEAVIRARCKGTTNRGRLAMNQLFPDLGDQVMRNKLKKLLDIPGRSAYFDRLVDAFHDLWVEHRGTAALPDPNPTSHIEFDLKRHVTFMRQHVNKHLLRLPTSAQTAVKEQPIQDLPKNVSEITEKYSWEYLKHTNTSFDLVLDTAALAEETRLHNIALGSIVEGAQEDVKPDLTISSGRRSGVIRSMIVGSPSETYDMSHASRILSWPREEYELIMSSMVNDGILLKSSVGQRTPGRMYGFHASWLAASEGSLPSDIDAEVTKAIKRFDEAEDRTITWPLLGNSGDLAAVMSLVSNHELDFDLDDCDFPTLKQSRLMYNTRALNDDAFEFDFTATRLEETPRKWSPPPAMAPREAPKPRPWGGDLSAKPWVVERIVKATEVAGANGIQRGDLQAQTELSLEDVDASLAALALEDTPRIFWAGYDNARLVSSQHWDQWSVDLADRSHDDKESQADAVRVAPRRWVDIWGNNIPSEWERAVKLVVAHLITRPGITEHSLMARVSSALDRLETCDVLQFLIDSQLATRAYSTDVDRPLPPVHATDVNETKGVVWQATDDLWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WID8</accession>
    <name>K1WID8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WID8"/>
    <dbReference type="HOGENOM" id="CLU_1180927_0_0_1"/>
    <dbReference type="InParanoid" id="K1WID8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="26002" checksum="F7FA4134C1E2D499" modified="2012-11-28" version="1">MSLGFSSKLRQFRDMFRGRKEIYPPRFSANDTGVIQYEKRKRGVTYRLEEGHIMLRNMTELSYTAPPNTTLIQIFGPVGQLNRSSAGSMCYADLANASLPKSRCGRGRRQRHGPRAPQLPAEIDRAPTYRACEPPSSSPIPEIPPAVSRAPSYREREDVPGPSTMPAPAYRRNDPGPTSIVVPQPSRAASRAPSYRERDAAPPQYQSEWRGSASSLSSSSSMRSERSVALDKGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMI7</accession>
    <name>K1WMI7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMI7"/>
    <dbReference type="eggNOG" id="ENOG502S9MF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261462_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMI7"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="939"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="615"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1301" mass="145061" checksum="18886A8999ADB4C5" modified="2012-11-28" version="1">MRRCVCDSPGYSEGYGGDDEPVDSDEEKPLASPARGSSSTPLLPRPKKKRAPTTPSRARGNRQAPATTPGGNFNDLLLAAEMATRPGTPTRGQPATVSAARTTHYVPSTFESPSKKPRRAREAPATVEWSSRRMWNSDVSPRASSSRHEEGASALDLLAQASQDVATGGPSRLEGSSRGHTPLGPAIKLDQTPTPGRGFPSADDPFDTFASPTAGAAVPGLGKYVHLSSAMPARRVRSPYLKWTKEEDELLTRAVMEHGEKWDLVSKCVPTRSYHQSLAGSRGDDRGEKTATEPRIRVNNFLDVNTQQGDALTPPSPPNNTRKVSSKPNTPPPWPYPRTEVERSVSRSTRSARRRQGLPSPAIDTSKDLPDKRKSSSAKRRDGHETETGDQQEPEQQAGDEMSTQHDDHDTGGQPTGESMPGGMHSAPTGGGPPTEQVHDAPQQTTGLDFENMTEQQKSTAMLNLLLQQSKTLELQGKEIAAMKSRQDRLEQEKSSKATQRAKGSITAIDRELQDNVKTWRREVSHGAPSAGEPKGPQGKTVERRDTGDDPTQKPRSVRRHDARGDEANVQTPKPADATKTDREQPHLVQTQHPSPRYAAGMMKDGRGSTTSTFLERLAAQQTELDEQRQQFAREQQELRMMREDLQRQLDLLEKRQQEPARVHYQEQAVTPQPQQQQQLPSSSHMTKHGHMTPPDETFEYRRQSREDDDPFVARASRSDPRQQRVEQDPRKRLTYDGKFTYQAKDIPKFSGWGAGGKDLLSFIRAMDKRLTHCPDEEITLRPAVMFEGSALEWYDLLDDDVVNRITTWDEWKTLLKTSFLSCEHMYLVQTAAINKILKREDDVREYATTKQSLLRTAFPEMSEGNIGSLILTGTPAEWRAGIGYKPGVHSLPDLYLMMQQHAPQLSGMWWNEQLDRRDGDGRPTAEFYKKLEDLDSSSFTLAPKKKGKEKMSTPGSNQSTPSPPSRGQPPKNAEYWRRGQERVLGRPPTHPTPPKVPCPKCNRGYHYKEDCFQEDEQPQPQSNPKPSAPAQQNANNQPPKGDVEFNYVEDPCDLNYRPNNTFWINSQREARTREEHVQNSLALIVHKSSENKKQQETLNNMCNTTPKTFEHQPRANERRQATPVGRPSDAPTDAPVMGNRAQGTRDPDKTSTPANVSGSAPKGPARQVTTPPLTATVEEIEDDESPKIKTHQRLPTPPTQSQSESTPSEPKRRKSRSPPRKKPGSKKSNRPARSRSPSRQRAKENAAKLRMEPARVFERGDTVSTGWPLGQVRGRSHPTQRRCNGGQRPKSTPRDPGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMR9</accession>
    <name>K1WMR9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Poly(A)+ RNA transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000285">
        <property type="protein sequence ID" value="EKD02424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMR9"/>
    <dbReference type="FunCoup" id="K1WMR9">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMR9"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_4_2_1"/>
    <dbReference type="InParanoid" id="K1WMR9"/>
    <dbReference type="OMA" id="RPAKLTY"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="153"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="155"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="218"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="345"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="398"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="593"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="651" mass="69763" checksum="BF9248691846ADFE" modified="2012-11-28" version="1">MPFDPASLGPAASKPASKTSSTKSKTSKPASKPKSGTKSKTTSKASSKAEKEDKPAAKSKTTSKASSKASSKTAEKPAAKAKPASKEKPAAKPAGKPKSAENKEEPKPKATTNGTKRARAEEPKEPPKKKEVKRRRTGPQINPLPEAPPARGLALFVWGTGDMGQFGTGPDDLDEKPRPQIHKWIEEHREDGELGAGTGGIESIAAGGMHTLAVDEAGHTRSWGINDNAALGRNTANQPDPENPGSTLPAEDFETWPFVVKALEDEGFRAVKVAAGDSVSVALSAEGGLRAWGSFRSNEGILGFDGVPGHPKFQFTPMELPALARVEIVDVACGADHVLALTSDGYVYVWGNGQQNQLGRRILARRAAAGLEPERLGLRNVVHVAAGMFHSFAVDKNGDVWAWGLNTYGQTGLDSSEEMIIRPQKVTALSPKEHGGARVVQIEGGDAHSLFLFDNGEVWGVGRQDGNELGLAQDHPAQEGLKERRKEIQEEREAKVKEAEEALEKASEDDKEDKQMKLLEAQAALRVPMGEYVPEPVRLSFTSDRADRQIAFPPIPEAYEIVPDMPPWSEPATNPIARISAGTRHNLAVSKSGHVYAWGLGNQGQLGLGSVEEASVPTLVRSKQLRPYDAVDCSAGGQHCVLIAKKRDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WN78</accession>
    <name>K1WN78_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WN78"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1005391_0_0_1"/>
    <dbReference type="InParanoid" id="K1WN78"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="28944" checksum="84C3B2FEAAFA1D9B" modified="2012-11-28" version="1">MASVSARPARTAATLSTTSIASRASASAAPSVHTPPAASTTSLPVPGSRASVATTGEDIELSDLPTQTEPIVAIDDVQAPTRSRQLAISIASFFVIFTSCGMLFSFGVYQEIYQAMSLEPNTPFTGASAAAIDIIGTLTATFQTMGAPITTAFIRRFSPRVAIFTSAVLFIASSLLASYSQHLWQFVLTQGVLMGLATCFAYMTPCTGADLVRGAARPRHGPHPERDGHRGTSVGAGDPGAQCQLGVQEHAPRLGRDHDGPDSRVGVHHRLGSIAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPS9</accession>
    <name>K1WPS9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPS9"/>
    <dbReference type="HOGENOM" id="CLU_1090658_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPS9"/>
    <dbReference type="OrthoDB" id="3222594at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="255" mass="28458" checksum="1E8A2227FC561199" modified="2012-11-28" version="1">MMAYYSGLPSVNEAHRSLEDVQFDAIKADVGHLLAHFGDSFGMCLVHHHFDLLDGEVMAEGEDGVCKPRLTASGDKFYPKRFDRHGKAYEFSTVPQEPVPEVLFQAFRTLVPETVHLGLYSRQGDDEDADVVEVTEANDSERAHRMVPRGPEHDLSLAMFTSWFNEKGGRKCNGPCLESEGIDVGEGHPAMKEGAPCFPWIHVQKRGEEPAMKEGAPCFPWIHVQKKGEEPAMKEGAPCFPWIHVQKNAELGPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPV0</accession>
    <name>K1WPV0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPV0"/>
    <dbReference type="HOGENOM" id="CLU_960389_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPV0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35202" checksum="0EE0AA33790A4AA6" modified="2012-11-28" version="1">MAQLCSRVQSPPASPTSSGTSKPTEPEASAGRASAPPAKGLATHRPRVTLDHRYLPHIIDIIFDVADPSTQIKMSQVCHSWRHRILRRYYHLLNPTGNDEEVTFRHSSDGGQQTLRWPEHQLLLACRVIDITSSGCALDYTWVTTMTDTIRFTNPSSFCCSPPLPRVPFKRVICQNFWPPIVTSQWANITNLIVIYGDDFRPSPANKLMALPHVLPSLRSIVIICRERPTEQQTAQEKEFWMELNGALELWRARAPSRYPRVYIVSANGDRPALPLLMFPTVAWSLEQYKRIIGEKEYEIETEFGKILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTT8</accession>
    <name>K1WTT8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTT8"/>
    <dbReference type="STRING" id="1220162.K1WTT8"/>
    <dbReference type="eggNOG" id="ENOG502QQGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006358_1_0_1"/>
    <dbReference type="InParanoid" id="K1WTT8"/>
    <dbReference type="OMA" id="ACWLTRW"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="280"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1121" mass="120964" checksum="1F920ADD99B94C48" modified="2012-11-28" version="1">MSQHPSRSSTPNRIYSSSRLSSSRTSLHLPKAFHSSPQPKVLPFPDLPVRPVMSRDPSRGPSPVTSPGLSSPGSGTDSFPFGTSVDTATAAASGSSSGSNIRFGHTLSPTVSASRLNAGHSTPRPLRPRAQTASAITPARPEGFQVISSSSSRPDTPSSPPPQLTHAAPPPVSTVPAPVPIPAGAAPPTAPIPILTTSQPMPPRPFAAHPAVASPPTRAASIPHDPTPPLAPRESVRIPPTKKASLPPDPLPASIPVTPPAPSGALIDHLYRSLKTGACADVRLWVRKWGVGWLVHKMVLVQAGFFHSLFMGGFSETRQQNKSQIPGDEWTGEDIELTFDDPNITRAAFEICLQRLYSSYPQLHFPVSLLPTAAQPLTPSFPPPPEGKFPSLQSASQGLPEHTQLVTPRLLLSLLATATYLGQQYLLREVLAIVLRTVCPQTVNRYLYFAIGHGIGEEEWINQDEEGARGMESVAKTVASGFVNSSADDWSSMEGSDESRPGRVPRLSTDSNSSSYSDDGPSVMKVEGDSSVKSVTRSDSVRSTATVRPGQSGLAALSTPTVEEEGPEDYVMPHFYGFVSDRIGEACVCWLARWGMDVLRIEEQLAEVDPQHDGPLVWAQGGVPANFVAAVLSSDALFVPNEIERYRMTRRVLELRRASWQAMIEEEQSRAPSVVSEPESIEGWDEDERELAKVFVEGIYYSHMAAHWSAADLKTRITFEKDEDQDAGELGLTLTSNNILQQRRRLGPRVRAGSSPYAIHNTLSFSSLSSTLSSFTPAATDPLYHPVPSDDTTRIGAGRLVFLNPTTSNPITGLTNMPNLGPDWNGQTGNGSSKDTETPPQNEKTFFGILRGARRASEIEAKIKQTHVPLVAIPEGKPKEEKWSKLEPFRFSVEFWGVDKLSEKERLYSATHFYAGSYFNVYVTTTRKKDKGVQLGIYLHRQSTAEAFPPVCTPAGITDSPTSPEPTQANLPAEGRAASPIALHPMPSTATLHQPPTRLGLYRTMSTSPPTTGSPPMGTSPLPEMVGDRDPGNYLDPRRVTKAYFSISCASALGTALVRFSSAPDKFALSQSWGWKSSALRSEEYLSVPSPIEKEGESSLGWVGDCPEGGSLRATVVVGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU39</accession>
    <name>K1WU39_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Frataxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU39"/>
    <dbReference type="STRING" id="1220162.K1WU39"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1611969_0_0_1"/>
    <dbReference type="InParanoid" id="K1WU39"/>
    <dbReference type="OMA" id="GEWEVEY"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18490" checksum="3810460A24801CD6" modified="2012-11-28" version="1">MSFRLGARYLAQVPRLAGSAVTRVAFTAPRARRTALPALAAHARFVSSTPHGDPGVDPSIAVRDMTDEEYHDVADEDMDQLHEALEDLVENFSKDWEVEYSQPPNHQIWVSSPVSGPSRYSMSPDGIWVHHRRKGIQLGALLEKELREFLKETGAGEEWDGVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUC4</accession>
    <name>K1WUC4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000223">
        <property type="protein sequence ID" value="EKD04504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUC4"/>
    <dbReference type="HOGENOM" id="CLU_2575564_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUC4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="87" mass="9411" checksum="661B47A90E74BC3F" modified="2012-11-28" version="1">MPKLTPAGVLSGLYIWKQPLTQYTEEQKNKNKPLVPPGDISPKVSEEIKAAATAPSTDAKVAFDSARQAHSEHGQGDVPSKAWTNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUK3</accession>
    <name>K1WUK3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUK3"/>
    <dbReference type="STRING" id="1220162.K1WUK3"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528938_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUK3"/>
    <dbReference type="OMA" id="IRAKLYT"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="321"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="461" mass="48796" checksum="5A948EA1B4EC10A2" modified="2012-11-28" version="1">MSNADDKANAPASPSTPAATAPASNETPPRESISLKRGREGSVDPQAAPVAPIPPKKNRLEGDVLTRSDTKDSDLVADVAETPGRDNEAHSDEDSNGSAKGDGEPAAANKKEGQTVKEVRRKVEEMNWKEGEKPNAAAAAPSEEKEEEPEKKSEEGKDDDWVQVDKSEAKDDEESTLKRKAEVDAEGDKKRKSTSPAPPEPAAAEPPKKPQATFGAFSSKSSPFAAASGSKSSPFAAAAASSSPFGAAAAKPNALDSGSSTPNALDTAAKKPSAFGSSGFGSFASTSSPFAKKPSTTEEKKTETSTSFGDILKEKGDAVEEKKIQLDKQDIPTGEEEEDTIYQTRCKLYALDDQGGWRERGVGNLKLNKHKATEAARLVMRSEGVLRVILNASLYVGMTCLEDGKHVRTTVFEGKDRTFITIRVAAELASAIHEHTPLQSKANTKSPSPQKTTTTSAEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUN7</accession>
    <name>K1WUN7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_01151</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUN7"/>
    <dbReference type="FunCoup" id="K1WUN7">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WUN7"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="InParanoid" id="K1WUN7"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="200"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="472"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD04579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="912" mass="101793" checksum="D45E90F07A39B28C" modified="2012-11-28" version="1">MVQVQEPSAKRRKVDGGAGEDSYPSDFQDLLEAENDQGETDDAWPRPPLPKVNPATDTLVAESSLPQFGPTLRLFGVTKGGNSMLAHVHGFRPYFYVAAPSGFLQSDLTPLKDTLNTGSLAVADCEIANRKSLWGYRGDDNVPFIKIVCTEPKALPKVKDRSPASGLVQPGDDDVRKQHSVSSSLHDRHQGTRVLDAAADVQLVGMNWVEVPAGKYSVLRGSEKRSRCQLEFTMHYSDLVSHAPEGDWLTIAPLRVLSFDIECAGRKGIFPEANIDPVIQIAAMVTRHGEKKPFVRNVFTLNTCAHIVGAQVKQFMDERQLLLAWRDFVQEVDPDLVIGYNISNFDLPYLLDRAKALKIPDFSYLGRLEDTHFSSKAFGQRDSKAVNLDGRLQMDILQVIQRDYKLRSYTLNAVCAQFLGEQKEDVHHSIITELQNGTADSRRRLAVYCLKRLLDRLMCLVNYTELARVTGIPFNDVLTRGQQIRVISQLYRNAKDKGYLIPAMRSEGTDEQYEGATVIEPSKGYYDTPIATLDFASLYPSIMMAHNLCYTTLVDKATIQRLGLVENEDYVQTPNNDFFMTEKRRKGLLPHVLENLLGARKRAKADLKVEKDPFKRAVLDGRQLALKISANSVYGFTGATIGKLPCLAISTSVTAYGRQMIDMTKREVEAQYSIQNGYDHDAQVIYGDTDSVMVKFGCPDLPTAMRLGAEAADLVSAKFKKPIKLEFEKVYFPYLLISKKRYAGLYWTRPDKYDKMDTKGIEQTIADLLQNKIDMSQLVITKALAKLERMKKRDAGSAPALGDRVAYVIVKGIKGAAAYEKSEDPLYVLENNVPIDTRYYLENQLSKPLMRIFEPILGSRANSLLSGEHTRSIQIATPTVGGLMKFAVKTATCLGCRTPLKGSKGAFPYGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WV21</accession>
    <name>K1WV21_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000216">
        <property type="protein sequence ID" value="EKD04654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WV21"/>
    <dbReference type="HOGENOM" id="CLU_013968_0_0_1"/>
    <dbReference type="InParanoid" id="K1WV21"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="745" mass="81518" checksum="D783179AEDC07C08" modified="2012-11-28" version="1">MAVPDAQQVKRPPISLSFIEPQRHPIHHPVYNGPSKRSTISSPADTSNIRTNSISYERRPPIPSRDFQPPRPDLNRVWVFPTSSTASVVSSNVTSAPASPMPLSPMTLSPTTLPFSALGAFRPRRPTVTRRPSDESDPEFPDIDTFDLDEPAGHSSLRDLMLSPGKVMDAQLYQVLNSSWSEAELEFALCIAVARWEAFVPRTPSGTGYSRPVWPIDALVPRHYARHANKWDEFSPYDPASFRVPVRDTRALLREVLRRASGQDPANAVGVPRRTASSATVPRAKHYQRSSMFSHRSSMTVASRSPSPDAVAVAPNPAKFLTEHLKLFPDLHEAATDGSNSQNEQYRETLLRGQKDHLRSASSKRREEYLAMLERTRQQRAVATAQAKRRSMFSPPPVTEVDERGLRRLSLMSSQPSERMSISSYVPPPAQRYSLVSTHTSFSLNEGQSTPETSFTMPSSPEKHEAVQTPKSAQEYHDATMGRLEGRTSVSEKQPEDDDVDLVLRLAEMGRKGMAGSLPPGVVESARAKRQASLGRDVSVLGSPLTPTSTTPKVRRSYRESITSVSSRGSRYPKSPRSPLTHSHSPSVPNGVGLKQVRMNVPESVLGDMDGEAHDPHALAADSPVESDANVVSSAWHEGPLDGIGSGLGSSLGNFGSDFGVGEASGRRRRSGAAAPRWRRATPSGSRDSRASALSTISIPESLELEGDFEYGNKYRESHIEAPASSNKVWNTVGNWLCPLPDDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1V2</accession>
    <name>K1V1V2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1V2"/>
    <dbReference type="STRING" id="1220162.K1V1V2"/>
    <dbReference type="eggNOG" id="ENOG502QSHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_1_1_1"/>
    <dbReference type="InParanoid" id="K1V1V2"/>
    <dbReference type="OMA" id="YYWGDRH"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="144"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="569" mass="62597" checksum="DE0C1E7665F02613" modified="2012-11-28" version="1">MSQRSQLRQRNTRHAGRYAPKDRPGAPPTRAKPNRSVHIAISLIVLAAMLVFAQKQGNPQRPWSVDSGSRPLPKTYAVCSSEKRIYTVPPAGGLGATECVVVADKRVKDVGSLAHVRRTYGDRSAKIKAPDGKTGIKVIQIPAGYSLTPGWTDSHAHPLHYGEFRSLSLVGSKSVQEIVDKVEEHVRTKGVKSGEWVTGMGWDQTLWDVKEFPTADVPIVLSRIDVHAVWVSPAVLEQIGEIPLEDVDGGKVVRDAEGKPTGVFVDNAIRAYVTPVQPEKTDTERENFLRIVSDDALRLGMTGIHDAGLLPVEVEFFRRMADEGKLPLRYYTMLLCKNQTEYCGANVERAEGAGDGRWTLRSVKLYGDGALGSRGAALIEDYSDQPGWKGFLLTPEESWAPTIKKWYDEGWQVNVHAIGDKANRVVIDAMEAAIGDDPAKGRESRLRIEHAQIMTPADLERAAKLGIIASYQPTHATSDMHYAEERLGPERLHGAYAWQSYLKAGGRTTLGSDFPVEEPSPLKGFFAAVARTDEKGDSPHGPGGWVPEEKLSREQALRGFTADRELCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2V8</accession>
    <name>K1V2V8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2V8"/>
    <dbReference type="STRING" id="1220162.K1V2V8"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054227_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2V8"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF351">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE PVG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="408"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="463" mass="51478" checksum="4489FB120811FE43" modified="2012-11-28" version="1">MTLSAYDLFTFKARPRLAVVLASAVLAALIIFVAQLSLPDRPPGLQTATTYAAALDEEGVGTSHEKQWLLEPEGVQRSFEEPDYSLLSARQPHEIGCDIPLEGANSGKLAFIGIFSSSLNGKGRRDLYRKHILPEWPDEVEIKFILAHPPAVKYPLDSLKRLKILDGLKQEAEEHKDMVILDIDDNIDFGKTFEFFKWVAQHYAGDGQVRGRPRFVMKADDDTYLVMPNVVRTLQSLNCKKNVYWGTSAGSSGHFRQYFRGLGYGLSWPLVSWIGSADLPYAHKIKIEDARTGQWLRLLDPVLDPVQRIDYGWAMGDWNQLNYTTETVALPSDRDYTPEFGSDVLDIIDFGKVMPPNAKSPKYNKLSAMGQKDLEEASKVEKAPLPGVRAEFGSDVLDIIDFGKVMPPNAKSPKYNKLSAMGQKDLEEASKVEKAPLPGVITDLPDERAGPLDEPTPQPASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2W3</accession>
    <name>K1V2W3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000392">
        <property type="protein sequence ID" value="EKC98234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2W3"/>
    <dbReference type="eggNOG" id="ENOG502S9QE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826881_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2W3"/>
    <dbReference type="OMA" id="RWPRKDE"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046466">
        <property type="entry name" value="Borealin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10512">
        <property type="entry name" value="Borealin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Borealin C-terminal" evidence="12">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="336" mass="37656" checksum="E61A3A82D4622E9C" modified="2012-11-28" version="1">MSTKSRRPLATPMGMQTPKRKSVKSKSAQQAILDNFDLEVADRTRMMRQQLELALSTFLAQVDADMLKIPRSMRGMTLGELDACWAGSFVATSRAIAQKQFAEQHPERDQAETLELAKRKRESPLESPRNSKNPRTTTPAVKRRTTKSLKKRKPDLPSATGASTLPQDHVFAPRIPQTPRAPRRNESFFSQNGSPVDPTVVPDDDLPDPDEMERQAEAEAEAESIRSGRSGHSRSQSTRSVASGRSGRTMQRKPSLLFRRNVDEDDDEPDEGASVIPLSDGRSIAFNPMNLTPGRIEAELSQGGFLNEDEKRRVRDQVQQEAVKALQRQMDRWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3M3</accession>
    <name>K1V3M3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3M3"/>
    <dbReference type="HOGENOM" id="CLU_998153_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3M3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="261" mass="28221" checksum="1E188C42C6291384" modified="2012-11-28" version="1">MRRSAGVMKQSVARLLRRSGEEAGGGETLRRLERLRLRQERHTQAGWPQMNKNRSVAVRMHEQGSKGAPEHRNTATRGVDVTARSRFETSHLGGARKVYGEAVSLVSNVMSGQSALASPCDSVARPSQSLSWSWRDDGKIDCGETLGVGTGKAAPLPPPLLPLAGLWSDAQLTLRTAPAPRAPLDLTSLDIVSLLLSPVRRLMSTPLFLFSPPHLILLAFSSLSISAPHSSPSPPSQSPLRLSIPRPRHPSPTPRRDALPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6G2</accession>
    <name>K1V6G2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6G2"/>
    <dbReference type="HOGENOM" id="CLU_1628225_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6G2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="163" mass="17961" checksum="DE89F5F17EB7C22B" modified="2012-11-28" version="1">MAPTTRSQAKIAKAKDDLDALLNHLTSLETDAEAMKKSALARLLATGDSDSVINKAISSRSIILATCWSMVRTPGGKVTRVVAKLEAALDEYAQRLEHPPLRVDMSQYSQIDNQRMESSCASIRGHMENIQEALEIMKSLMEILGTEGVSFLTRPAEMRVNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6Y5</accession>
    <name>K1V6Y5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_05948</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6Y5"/>
    <dbReference type="FunCoup" id="K1V6Y5">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V6Y5"/>
    <dbReference type="eggNOG" id="KOG1357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="InParanoid" id="K1V6Y5"/>
    <dbReference type="OMA" id="QPRANGC"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="20">
        <location>
            <begin position="263"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="20">
        <location>
            <begin position="536"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKC99764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="714" mass="78756" checksum="51CB46784F1A46EF" modified="2012-11-28" version="1">MSRKGTPRSTRSKGSPAATNGTPSPSRSPSKPSARSALLNVISQPKHSHPAVTFDSSPFEDANEKGSKNAAGANGHAHPEEEIYSDQSTVSSYASSTGSPVRTPTDQEIHDMYDGYLTKPNIKVKTDYKHSEFGHCNNQNYRWTSQYNPAEPVTPEIEPQPPYYILLTTYITYTIIIILGHIRDFFGKRFYPSHYAHLLPRNGYAALNSDFDSFYVRRLKVRLDDCFSRPVTGVPGRTIQLLDRYSNDSYESFHLSGTQTRALNVSSYNYLGFASSSGGCADAVEEGIRRYGVAGGGPRHDAATTDLHHQAEKLAADFVGAEDAVIVSMGFATNSTTLPAFVDKGCLVISDEFNHASIRFGVRLSGASVRPFKHNDMNALEELLRDSIAQGQPRTHRPWKKIIVVVEGLFSMEGTLVNLPAILDLKQRYKFYLYVDEAHSVGAMGPNGRGVCDYFGIDPREVDILMGTFTKSFGAAGGYIAGNKEVIRCLRMRSHAMCYAEAMSPPVLTQIIASMSAIMGISPPLPPPVERDDSDAASALSLWSRNQSFGPAVAAELPTWLSLPRELSDGSEGRERLRRLAFNSRYLASGLRKLGFIVYGHRDSPIIPLLLYNPGKMGMFSRMMLNRLGPDKTPIAVVIVAYPATPLITSRVRFCLSASHTKTDIDLLLRACDEVGEYLNLKLTDEHWPVDQVIARAEELVAATDLDAVKIWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1V944</accession>
    <name>K1V944_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V944"/>
    <dbReference type="STRING" id="1220162.K1V944"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="K1V944"/>
    <dbReference type="OMA" id="KPECTGQ"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="371" mass="41031" checksum="F78AE9441A3BFE92" modified="2012-11-28" version="1">MSGSSGREIPCPPYPARISRPAESLISSTSDLLFTQVTPQHNHQHDRASQGIPHGYIASWITLYLLEAGYRVRGTTRNAAKGQWMQEMYASRGLKDFEYVIVSDLENANAFDEAVKGVDAIMHTASPFHWNVAKPDDFIKPAVAGTESVLRAASKEPRVKRLVITSSYASILENRDPGTATFTEDDWNQQSIDAVEKEGTEAWRMHWYRASKTLAERAAWKYVEENKPSWDLVTVCPPTSREVALTSAVANWYSYLTGEKTTEDAIAPAGILCDVRDVARVHVKAMMLPEAGGQRFGIATLHEHSELIAEFPKTVKGQPGAPVPTINWFDCSRSLKTLDMTPTSEVSTAVDMTKSLAERKAGWAEAKAMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAG1</accession>
    <name>K1VAG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_07939</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAG1"/>
    <dbReference type="STRING" id="1220162.K1VAG1"/>
    <dbReference type="eggNOG" id="ENOG502S7CC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108081_1_1_1"/>
    <dbReference type="InParanoid" id="K1VAG1"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC97740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="108" mass="12988" checksum="1DA2D12D7E8D4BD7" modified="2012-11-28" version="1">MSATPATAFSHAHKAYVKSLYRRYLANELDWYIRRDAWRQRAMEIRAEFERNRNVSDPRALAIILEKAEENLRKNQHPDPYHPPMFPDGTKWERNIPPRMFTEEEAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBP9</accession>
    <name>K1VBP9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBP9"/>
    <dbReference type="HOGENOM" id="CLU_2251935_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBP9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="104" mass="11029" checksum="54DADC6CBDCF03C6" modified="2012-11-28" version="1">MSAKEKEDPKRAEEAEEPRKAGAEEAANPAEEPKKKKVETSADVAAEKADDGGDEDVQLGKRKADEDEAPANGEEPPAKREETEADVAEEKKVDGEAPSAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC38</accession>
    <name>K1VC38_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps52 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC38"/>
    <dbReference type="FunCoup" id="K1VC38">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VC38"/>
    <dbReference type="eggNOG" id="KOG1961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029212_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC38"/>
    <dbReference type="OMA" id="PIRTSMT"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps52 C-terminal" evidence="3">
        <location>
            <begin position="217"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="3">
        <location>
            <begin position="381"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="572" mass="63173" checksum="D0A2683CCE1651B5" modified="2012-11-28" version="1">MQKEVSFTDDHSADSQGALETPGAGPSRPPSPPALPEPLLDEADEDADRELCKRSTLIWRARSSAELLTSLGSYLETFQDNLSEVSGQIADLQQRSDEIERQLKGRRNPQLWLQAVQELEEKLVSVKARGAKVKAARELEGVLEALALKAMHALPPFLLTLIRPLRSASKGLSTNLAVMQTSLLLKYQPFYSFLLRQSPRHAKQVERGYVNAARSYYETAMRRYARALSTIRARTPEKSELIGVVPAEEAAAPVDRTPPSAKQTYGKLKIAELNMEDDEGAVVLAYTMDNKETTAPVEQLFRSLGLVLLDNGSAEFTFIVRFFARAGLGSGSSTPKPPNVRSPNSTPLDSPVLGPMSDAGKSRGGRRRGNAAAASAESLKDAERIWNEVFGSALEYTTQFFQTIVTTPPSAASLLTIIRLNDELIKTTESRGALPLIPYLTGWKLALWPVYRKAMDAHIDSIKALADQAEGKGLTSWVSKAVKDSQVRHVALRYAVLFSMLRMRNELIRLIKIQGDKIKDVPARQSFLSSTYEIVMRELVAGPGAPTNAHLQSELSFFRTREEEARRRISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCK3</accession>
    <name>K1VCK3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCK3"/>
    <dbReference type="STRING" id="1220162.K1VCK3"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400711_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCK3"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="273"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="692" mass="75828" checksum="C456429F344FD5E5" modified="2012-11-28" version="1">MSNPHQQPHDYARYPYGVPIPASSSSHGNASVPVENMKGDLDRQLAQSEAARNERHAKTASWGSYNQFVGVEAGPSTPGTQYMGNPYDAPLTPQRSYDHTPAGSPSPSPSPAPGTAYHYRPTRQASREADIADGIRREPSPEGERMSWHAKGGNKLRRVKERIQYDEEGKPRREKKDKYGVKEIPEGWTAEDEEAEREFLASSMFNWQELMTWRFWIRKEWWCKLERALLEADLRLIVKWLTPAANWMKNLPAGWVIPIAVMFIISYPPLFGHEIVAILCGVVWGLWVGFGIVAAGTMLGEIGNFYAFKYVCQSRAEKYEKKNINYACLAHVIRHGGFMIIVAARLSAIPGHLTTAIFATCGQNIFIFSLAAFVTLPKQLVVVYLGVLFNAEAKSKTSQAISYTVLGIGAVITVGSAWYIYHEMNKARIVIWRRHRMALAQKGVALNELVYDANDVEVGGTGLRDNAGRPMLPAYATQGYNDSREEIMSEATPGSTPVRPARPGDRASYATPYDIAYDHDGEMSIYHVDGLSERLETEKRVSQQLLDRRSSRGSSSAHAAPQIRVDHAGPPPSAFPPSFPQAHPAPGGLQRAPSDASTYSVHPVAPANFPAPVPSQTSHSHEQSEHTAHTAYSAPSAYSQPSAPTHVTHPSEGSIGVALGGPGHAVHAGHAVHASLGGQAEARPERQHGGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE61</accession>
    <name>K1VE61_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxal phosphate phosphatase phospho2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE61"/>
    <dbReference type="STRING" id="1220162.K1VE61"/>
    <dbReference type="eggNOG" id="KOG3120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068983_1_0_1"/>
    <dbReference type="InParanoid" id="K1VE61"/>
    <dbReference type="OMA" id="HNLADCF"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32017" checksum="6EAEFD076BB302AF" modified="2012-11-28" version="1">MVKNLVVFDFDWSFVDQDTDRWVFEVLDTKLRRKLQDRKSAGSQCMPDVVSAGNALSERGRRRRQEREHLGTTHPLPLTARPVSQRADHSDETMEDLFNAGYKKDQVLDALRQLPVHPAMKRAVTNLKNRGETTFLCLSNSNEVYIGTILEKHGLTDLFDQVITNPAKWVGDRLHIGRRLPADGPQHGCTVGCLPNMCKGDELDAWLEAHGGKGSFDKIVYVGDGGNDFCPLLRMREGDLGLVRKNFELEKRIEREGKEKGCKIDVTLWDQAWIVDEVFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEA9</accession>
    <name>K1VEA9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEA9"/>
    <dbReference type="STRING" id="1220162.K1VEA9"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_7_1"/>
    <dbReference type="InParanoid" id="K1VEA9"/>
    <dbReference type="OMA" id="NLMGAGC"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="202"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="410"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="619" mass="66258" checksum="4DDB4913EF417BAB" modified="2012-11-28" version="1">MARADAFGSLSGGGYGPGRSRRGFKVGNRTQLEPSSFLALPSLRRQALTSGHLASNAWGSTSSIPHAIGRPPQPAHTLCTQEQYKFTATTSSSPSLPSPLPTLPSTMVAAAARANAVRLMSLTASQGCRGCGRSHAAAHSCTPGSHDHGHSHSRGLATPVDVPGPGNSKGDYAFEMAASTLRFGTGATREVGMDLVNMIKRLPAAEQKNAKIAVFTDRNIAKLPVMETVARSLQDNNLNYEVFDRVSVEPTDKSWTEAIDWARNAGVTHFLAVGGGSTMDTAKAANLLSCYPEADMMDFINAPVGKGTPINKQLKPLIAIPTTAGTGSETTGTAILDIPSMRFKTGIASRALKPTLGIVDTLNTATCPREVAIAAGLDVLFHSLESYTAVPYYERTPRPTNPINRPAYQGSNPVSDIFSKWALEQTVKYLPRIFKDPTGDEEARTQMLLASSTAGIGFGNAGVHLCHAGSYPISSLNKARAPEKQYFHPSYNKDVPLIPHGIAVSLTSPSVFDFTAPSDPERHRTAAAIFMGDRAEELRNVSDADIGKVLREEIQKFLDSIAVPRGLSQVGYTSSDIETLAKGMLPQRRVLDLAPVLVKDNQNEELDQLQGILEGAMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VED6</accession>
    <name>K1VED6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VED6"/>
    <dbReference type="STRING" id="1220162.K1VED6"/>
    <dbReference type="eggNOG" id="KOG2634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027654_1_1_1"/>
    <dbReference type="InParanoid" id="K1VED6"/>
    <dbReference type="OMA" id="WDENIYL"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="337"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="379" mass="42134" checksum="32123D1F15BFEC7F" modified="2012-11-28" version="1">MSDLKAVKKHAAQHDLFNRIHSIASDEQFVRNVAERWFNNRFKVVAQTSSSVYAYFKSTDGHTLVGWHIGRILTCAELGLQLEKVKPAAGRMGREERWRMPDGLSKTVPIWCSVVNRAIALRRDLDDWDENIYLPAIVSPSERSQIEAKLDDWAEKLEGLKPALYHRHKKDLLSASRDELPPLVDNLVQDESVCAPLQALDLSEDSWARATQVDEAIALDLGKTTGKLAFEPPQVWVTVWVAEVRKPYSGPTIVPLSNGDAFFAVPCPRAEPKAYVVALRQLHSHVATSDRGVLLAPAMQGDLEGLPKPPTAKLDPAALSQARKVIIPVAVTLMCRDDSVVDKSVIADRLHRLVALWPDGNPPRAALKRVNDFFMSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFG1</accession>
    <name>K1VFG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 14">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_07819</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 14"/>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFG1"/>
    <dbReference type="STRING" id="1220162.K1VFG1"/>
    <dbReference type="eggNOG" id="KOG3924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027287_1_0_1"/>
    <dbReference type="InParanoid" id="K1VFG1"/>
    <dbReference type="OMA" id="PIMCLES"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021162">
        <property type="entry name" value="Dot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017570">
        <property type="entry name" value="Histone_H3-K79_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 14 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="17">
        <location>
            <begin position="259"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="397"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="483"/>
            <end position="484"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR017570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017570-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC97816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="598" mass="66093" checksum="2C9562B383AA4FC6" modified="2012-11-28" version="1">MQSFFGNSKPSSKPGVSTVTVKKVVHRPAAVAKPSPTVTLQKKPPSSSSYDRKPASSSSKSSFSRNSPAHAAVSKSKTASPAPRKRRQSPQRVLPPSDSESDSDDALAPKRRRVGLSASTPDIGGADTPVDRKLFCPQLVDARGEWGRGWAGFVECEEALRGRVTGWAGGDKESKEQRDKYQAYFPQPGFENAEPLPSVELRYPSGATEKFILLTPMSQREYNPVSELRNALRLILKRELYSSSTKLMLDYIPLSHSHIFGTLESSGDFESTVPSRLHTPTPGASPAGEGSPMPTHETIGDALRRALAPNRRDGPGLVKAVKRFNKALAEIQADGTLATYLNSSEYRITRREWSELVDFVHDQAYSRVVGPFSDQLEHHPKHPDEVAAAIHEKEDAYGELRHNFMSKVIEQTELGPDSVFVDLGSGVGNCVVQAALQAGCKSSGFELLPVPSRCARMQLAECKRRWAMWSLKGNTDAITYEGDFTRHPEVARQLAKADVVLVNNEVFPSSLNIALTHSFLDLKDGAKIISLKPFVPEGFRINEMNCDSFASILKCEPYSYYSGWVSWKADSGKYYVQTVDRSLRLKYEEQMNGRRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFW9</accession>
    <name>K1VFW9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFW9"/>
    <dbReference type="HOGENOM" id="CLU_674710_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFW9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="408" mass="45482" checksum="4AA08D81BACE2D62" modified="2012-11-28" version="1">MFCTRCPPTSTCASTLFADFPQVASSELAVSRGDEHDPIRQFPLTTHTEMWSQVLELLDPFRSEAAPSPVDTQSAARPSFPPIQPTLPKKGVEVQVYPSPSKPMSPRRLLSRLPLVQTPTRFTSLFWRHYNESPRYYPDLPLVQSPIQVADLERPVTPLSLESPSSLWTDSDTLCPSQSSGAVASSKFQTLKRWKNKKKGRRGGSLKTILLSGKRTSSPPGPRWVKSLRKAAHWMSSRERRKSSSQSRAVRASPQRRDAIWRSASTRDYSVYFPRPLSLERAQEVPAPPSSPSSVYSQETFHSLFDEDPSDDCPADDEMDILLDTVSEMPTPLVPSPSTPPKSRLVGWLDAAFRAMWWENVAYGLGRLAFCSTRLALRITLLAVPPLAAWAAFRVSDAALRTTFPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG31</accession>
    <name>K1VG31_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG31"/>
    <dbReference type="FunCoup" id="K1VG31">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG31"/>
    <dbReference type="eggNOG" id="KOG2165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007149_4_2_1"/>
    <dbReference type="InParanoid" id="K1VG31"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="392"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="637" mass="71756" checksum="0C50A9E465EBF6AA" modified="2012-11-28" version="1">MALASALAAWDVPSTSAQGSHQAEILKVSTFGTACVTPSVTAAFSLLKTEGKLTELYQDFTDSVQNRFYLVKNDLDTYLSALQKLPRIIRRSKPSWRACLTESQPGSGLGAPHCDSWKTFFQHLLYASLPATFPAYLLDFLAQSLAALSITPGDEYQLQERRRVPAPSPHLHRLNVLPRFATSLMRVAYDEIEKIAQEAAALGWEERRLQTARKTVSDSVVAWMSSVFESECALVAKADLSDYENPQAMLRPVYSRFDYYLCKAFFDIRTDELFDIIVDFPDSMAALEDLRRLLHPGAETKDVITQYISTIRCLRILDPLGVLLHKVAEPIRRHLRDRPDTIPQIVAALVEGEELQDENDPASVEPLAFTNDNTVEKFWDPKTGKTVDIVGTLVSIYDSRDAIVKELQSYLAGRLLDIDDYDAVKEVRTIELLKVRFGEDALHVCDVMLKDMADSKRINDHIQQDITSIVEPLIISRMFWPEVEQSSLHLTPKLKEVEEQYGAAFNKFKPDKHLRWVQELGKVTLKLEMADRVVEAEVTPLQACVAELFETQDRWAPADLAERLGVDEPVVLSALGVWEGYGLLREAGDVWETVEYEDGSGSAMQQERPQGRLAFDYARADISRGLCADEPERGRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGY4</accession>
    <name>K1VGY4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGY4"/>
    <dbReference type="FunCoup" id="K1VGY4">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGY4"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="InParanoid" id="K1VGY4"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="70"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="357"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="480" mass="52200" checksum="B25E6677469756B7" modified="2012-11-28" version="1">MAPVTKGVILVGGPSKGTRMRPLTLDCECPSVRHHHPLRITPSTPTHINVNIIDPEPDLLFNVRRADITGPKPLLPIAGKPMVWHPLAALAQVPGLTDVFLIGFYEDSVMAPFVKEAQREFPKIKISYLREYKALGTAGGLYHFRDAILRAPVPDHIFICNIDICSTFPFEKLLDVHTKHRGVGTIMGVPVKKENASKYGCIVYDPDTSVVLHYVEKPESYISNTVNGGVYPPRVHICATPSPAPAALRPWSQLTSVFDKAVFDSIKVAMDEKTARASLNPLAPSDEKLQLEENVIAPLSAARKMTVFVCTEPWRQIKTAASALAASALYLDSYKAQHPELLYHQQQQKDQSSCPTIVEPVYIDPSASIDASAKIGPNVAIGPGVQVGDGVRICNAMVMEGSELASHAVVSQAIVGERCSLGLWARVDGEPEREDEEGKRDISVSVLASEVALMPEVHVRSCIVLPNKTLGKSAAKLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH07</accession>
    <name>K1VH07_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH07"/>
    <dbReference type="STRING" id="1220162.K1VH07"/>
    <dbReference type="eggNOG" id="ENOG502QVMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534406_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH07"/>
    <dbReference type="OMA" id="IWEAVSA"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="510" mass="56568" checksum="BEE6A91579DD346D" modified="2012-11-28" version="1">MVSFQTGVDADEQTADNESTVHLRIRIQPAAKAPLTIEPIQIMGISSVVAPNTTALLFYNERLDDGALFDSLQHFLTVYPFLGGKFIFASELGDDKPADAAAYTLRHLRTWIKWGTETDPGMPFTVVQRKDSMAAHQPRFVQNGVTDLTPFHGNALTPPTKGLLADRDTPCGMIQVTHFTDGTSVALSVSHMLADATTAAQMLKDWAAIHRSLAAGKLEIPSRPFHYADVDGQAAGDLNSEFEDPVQTEIESKQDMFRYDGWASGMPIPDHLKAADERQGSPRGKPLPPNSLVFAQDVAYHAVHFSAADLERIHARVQGQAEGFVSIHDAFAAHLWRLMTRARQQTGTLDLNVACDARRRFPRPLPSNTLGMFNTCLGFQGEADVLLGEKGEAWAAQRLRQAIGSFTPETIAAFLHRRAHDLHPMREQICACHPENTIMTTWARAGLEDVDFGTGKPVYTHFHVQAFPGYVCIMRECGEGEKWYEPGLHADLWLETEAMERFLADPELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH51</accession>
    <name>K1VH51_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_02257</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH51"/>
    <dbReference type="FunCoup" id="K1VH51">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH51"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="InParanoid" id="K1VH51"/>
    <dbReference type="OMA" id="CEIACIL"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="14">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="14">
        <location>
            <begin position="192"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="15">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD03450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="469" mass="50435" checksum="857D8DA114660789" modified="2012-11-28" version="1">MAAPKTADTFVVGTRKSNLALTQTQFVADALALRNSAQFPVRHMTTVGDRNQTTPLHLLQPYQSGQPAKSLWTDELEAALLDGRFDVLVHSCKDVPTLLRDGCEIACLLERHDPRDALVVKKGLEYKSLKDLPKGAVIGTGSVRRIAQLSRAYPDLKFADMSSASAKGLGEMPSAAMVPSGWLSLQLPSPGHRGNLNTRLAKLDAPDSPFAALILAISGLDRLGAGERITCPIEFPDMMHSVGQGALAVESRSGDAATRDVLRTVGHWPTEWRVGAERGLLRVLEGGCSVPVGVETHLTELEGADAESAQLQYTPGTFPAPTASSPLLHFSGILPADAPFPQPGEEPKLLQRRAKLNLKASVTSTDGSRQVVYEPGDVVVTNYQEAVAWGEECARQMRVVGAGEILDEIEAERRAREEEMLEKSRAELAARAAIDDTEGQECTRPGKENETVPPPECPHDAGQGQRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHD7</accession>
    <name>K1VHD7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHD7"/>
    <dbReference type="eggNOG" id="ENOG502RV8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_829460_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHD7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37941" checksum="9375C826015C97C7" modified="2012-11-28" version="1">MSPADSVLTVFPIEVLQHIAVELDRPDLARLLRVNSFFHQAFVTSLYTRVPSVVIQNLDPGSAHRRPPLRLPAYARHVRCLSVPVWPASCCRLPSKLPHLPSLGVIILEAALPHGHGIVRLPTEEETLCPLPPTLKPKTVVMRYPFIYDGGAQFPAGLLTESTELVAFLNLSGGIDDQPGALSFGTLLDIVDFEIPESVYNMTIVLDPSTRSDWKFFNVATLIRLCDHYTEGSIFPFENLLSLTFVLGDGSFASSSRDAILENVRSELRENVHKAAADPDFEPRARPFEINIMLLHEFLASKKYSHVLSKEETAQYLLAPSSLKHVDTGGDVQDVIGRARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHM5</accession>
    <name>K1VHM5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHM5"/>
    <dbReference type="HOGENOM" id="CLU_440883_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHM5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="620" mass="65850" checksum="1E3A4616B8527404" modified="2012-11-28" version="1">MLPPQPTGSHSPAYYYHRDRINRRYHVLGQQTISAGHEFYPQSALDPWAAESVRIGLSDSLARLEYHRKLELDELLAAEFGDPAPSSLVNGAHQSMPMPVYSPIPLHHTGMMWGPSGRSIVPGTLSEPFMEVHAPVIGQYHYGAPASGSGPDNTSTHPDNGPQTPVEYLYSASNLSNSNRSAPPNSDRESTSRATLDGTTLVGHGRPESSTAPPAPVQTSPSKRSSRYSSKRSASKASRSATSSAKSSGTGSARRAAVSDLRPSSSSSTSSLTATWVGEASSSQSSADVRHGDETTVGGLATKQAPYVDAYPLSTSSFTATSSGHPLSVLTSNISPDDSISQHGTSTSSRASTIPIPTMPPTSRIKSQTNAARQAFSTCSRPSQTRGSTLSPIAEASSSSSRSQTQSVPSSQGRTTARSTSGANEHSEETNSNGGCGKPIHIKSSPSSTRSRSQLPANVSPSRSSRSSGTPSSGPSAKSNPTSSSSGHLTTPYMAYAGTTMETEELKATSPERWRAVARANAFDGLLLVAVTAAFGNPDLLGRLKRHEGRFHFYNALEAEADFDGRKFTPEERRIGRGRHFDSVRIVALTRRGGSDELPKEIAEKVQRFHNLNEPSDDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHQ1</accession>
    <name>K1VHQ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000244">
        <property type="protein sequence ID" value="EKD03630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHQ1"/>
    <dbReference type="STRING" id="1220162.K1VHQ1"/>
    <dbReference type="eggNOG" id="ENOG502RV66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033167_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHQ1"/>
    <dbReference type="OMA" id="LFFGFWR"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="8">
        <location>
            <begin position="379"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="557" mass="62772" checksum="2FD2C546990F0D1B" modified="2012-11-28" version="1">MSWHPKRRDVLLILTCLVVVGLFLQLDFSGSSHSRSSSIFKIGGLSRRPAFEKGGQRVNYAPTRNTVSQPKLKWGDRGAPHTKIVSHAPGWTIFEDVYLFNGTWFIVTDNPSDVPLIRLMASTGAEIWNDEGSIKNREPTDKDMRIIFPSEAKKLWGSSASRVSGTSFVCNDPPQFLDHYYHFAAEFFFGMWRTYSSLDPGINAAGETSLPAPSRLIFPHTAAGRWNDYAKMNSFILRAVFPALSYEYDGDFADRKDTARAYIYDRVVFADRAAAFRGPEFGKTWRTSSEAVTLGGSRYWWSPIRRNLIEFVGGKSGSALNLQEFGVDLDQEYLDNDALQEMGIEIESPSTKTPDRRSIDAAVERRAIGASDEAPQKESRKYAPSNPVITYVSRQDWGRRMLKPEDHDTLVKELGELEKKYGWEVNIVAMDKLSRDEQIRLAARTTIMMGVHGNGLTHLLWMNNLNPRATVMEFFIPGGFAEDYEYTARALGIRHYGWWGDHSFTYPNIPPVEYPDGFQGNSIPLDGKAVAQLCEQRLVVDRVADKAKDKRTGEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI17</accession>
    <name>K1VI17_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI17"/>
    <dbReference type="HOGENOM" id="CLU_452834_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI17"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="527" mass="55933" checksum="69BFEE29D5FC846F" modified="2012-11-28" version="1">MNVTGWSPMFAYLEGWDLNFEDGSVTSLPPTGLDARAWLHFIGTSAVPYGSANRRTRTTDTVFGNFTLKERTSLTANFGPTDPGEVLADLGTFRLGSYTIRIVPSGSGLINVQYVLFELPIVTEASTAITTPTTDGDRVNSAFSIRRFESDDYILDGGEQSPAELSPTPPSQHEIVNGSVLLGGLTEMTFSVPPNTSLVNVTGPVYGDNSPSRSYCYAILNPEPWWWNPRALPKADAQKQGYRPDQTLLMLPLDPTVEYRLVIGALGRTRTCSISGITTYSYVKSGPSGPSAAVTKGGSIRTTKIGGPTTTVSGKPSESADVVQSNSRKVDAGVIAGPVVGVIVGLVLVGLLAALVLRRRRQRSQSTAIQPVDNEEDSDRFELTEDVQVVVPFIAPSRSSASNDKNATEERHKGEGSESQTAYSSKLEKHQESSIQGVAPSSAATAAVMVSHPPHHAEDMEDAGQDALLPPVYKAAWGQRYVSGAVGGEGAVAAPREHEGDAAAVGTDPSNFASNTKGEACGRLGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI46</accession>
    <name>K1VI46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI46"/>
    <dbReference type="HOGENOM" id="CLU_1262304_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI46"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851881" evidence="2">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="219" mass="20688" checksum="BB2DABFB4944A0AB" modified="2012-11-28" version="1">MLFRVLLSLAIVAAGVAADSPMESSSSDPLLASGTQTGPQIDPTENPASESAIDPTESLSAAPSQVTEVGVGKNGEGQDDTAPSQVTEVGVGKNGASETAAPSQVTEVGVGKNGGSESAAPSQNTEVGVGKNAGSASATPTSGASKGGASADPSGGNVKPASSISKAASAIDSGTTGQKASASKSGAHASASASGKSSANTLEYSFALGVGAALAAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIR8</accession>
    <name>K1VIR8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIR8"/>
    <dbReference type="HOGENOM" id="CLU_1367102_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIR8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="21949" checksum="D729B7BFA2EFECF7" modified="2012-11-28" version="1">MLWRDSLTVPNSNGLLSASSSSEALIGGAAIPTLSPTGEQIQAVRQHAVLRKKRREVSTEWRRRAELQGRPYDTAEPHRTAGPRSGSFSASETQARQRRASLVQLVVPRRPGKSATTSSPSDSSEESEPNCPARPLRRSDNANPFEQDDTDEEETDEHGRRVVSFPLTVNVGAPEAELATGVEPKPKRRLSDIWKGLGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ75</accession>
    <name>K1VJ75_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ75"/>
    <dbReference type="HOGENOM" id="CLU_390875_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ75"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="706" mass="77740" checksum="262363625F3441FA" modified="2012-11-28" version="1">MLSPRPPQVALPTSTITIKPHDDETAPNLPNLRIQVFPQGLVVNSPPLSSRPDTKALAHALKVFVPLNGKLHIKISLDLCSLVVSVTVGLERITRCPEPRISASEEDDVDLHYRVLPKAALPEHEWFKQQMVASQEPYIHLKEIRLRMSWSKAPNGAPRGSAAIDHPGSYLDAVHRQLRCGMRRTLRLQFIHLRSFVSLAAQHDTPLLTATRDLLDDIEETQDMMLRRQVEASVKVAPKRGPKKRKVEWSTSDAGDDGHMDIVANHLRRLGRRDDALAESSISRALMTIGVSEWSCVRRGQSKAGAGRIILENTPVPNTNPYDDIRNHTGESRVPSPLHDNKYKPALIPTHAFGLTVPTYQHQNHPSDRYESAMCEPQRNTYPFSDLLPLSPVSRASLPPPAPRSRCVQLPVLDDDLDFEYDSPEAECASSMGHIYIEDWSSSLSSHDETEELSAGLSAVELDFETSSVSNALCLDLHAGSSTFAFDSASDDFSDIGSGSGQPYVSVPVALPMQPFSPTPTHLLGDSELSDDLSQLTVDSDAPESSRRRRGRDGSAVPRVMSGPCISVMDEYRIKQPLETTPAFPAPFQRSLSDGHSTDEWASDWDIDMSPAPFEDDLADESDATERDELSPPGLDEDSDLESDGPSIDSPQESGVLMSGVDPRSKHQGSEPSQFTQIVDDLDFDDEVLVTPMEEDTPYSLTPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJC9</accession>
    <name>K1VJC9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJC9"/>
    <dbReference type="STRING" id="1220162.K1VJC9"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_1_1"/>
    <dbReference type="InParanoid" id="K1VJC9"/>
    <dbReference type="OMA" id="GRVEHHT"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="33759" checksum="644222ADC635F292" modified="2012-11-28" version="1">MTIKILALCGFTQNATIYSKQVSTFKRPAAMADGIGSGLAHWVSEFERWLGDAAFHIALVSSNFQNELGAIRKTCKNAEFVFLEPPVIVQKADMPWNQRLDDFASSATTEEAEQTPETTPRAWWLSPGDRSVYKHFDETVSYVYDFMQKNGPFDGIMGFSQGACMAAVLGALPGLHPNFPEGLPKPKFIIAVGGFKPEPKNPDFSNYFPLSESLPVLHVLGDNDVVVTPERSQSLIDATLNGRVEHHTGGHFTPSKASWRHFLNAYINTMAEGGDQNEIPAVSSFGPSGANTPATGNGTPRTQTPTPGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJF6</accession>
    <name>K1VJF6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor iia small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJF6"/>
    <dbReference type="STRING" id="1220162.K1VJF6"/>
    <dbReference type="eggNOG" id="KOG3463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2960669_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJF6"/>
    <dbReference type="OMA" id="PQFRMEG"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="53" mass="6048" checksum="E40FAC7590CF6A6D" modified="2012-11-28" version="1">MRVLQQSLTECLQKGVKQKTSVKGHLSTYRLCDDVWTFVVKDPQFRMEGTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJV4</accession>
    <name>K1VJV4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJV4"/>
    <dbReference type="FunCoup" id="K1VJV4">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJV4"/>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="InParanoid" id="K1VJV4"/>
    <dbReference type="OMA" id="MAIMIYA"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="118" mass="12900" checksum="39BD133085FE36A2" modified="2012-11-28" version="1">MSTQPLLQRTAKKRIALPVRVEPKVRTFLSWLHFAVVLGGLAVGLLNFGDKAGRISAALYTMIAIGVMLYALTVYQARAKAIRERSGAPYDDRLGPTILCIALLAAIVTNFILRAVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK17</accession>
    <name>K1VK17_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK17"/>
    <dbReference type="HOGENOM" id="CLU_947284_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK17"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="294" mass="32776" checksum="4BD427406D2AAC14" modified="2012-11-28" version="1">MRVTVSPESTILSPAPTDSTPSARESLLPSRKVSDASTSRASKSSAEVTSPPALGKRRRITAKAHLAPSPDSSDIVLSIRDLPAWTIGFPPHRRVKEALRVSLSCGGIEVDSEKDIDGLRHDSGLDFGKDPRLSDLMPARGCHFTFNFCAAHELREEQRIARQNDPERIRKQRLLMRLNPMKQTETFNALTIMSREGLPDGFGGVYTRQDLEYIRDKLIKFAPLEWRTQEWYRDGLREMGIDPDASAAKPLETNEHSPAVSSRRDSDNTSSQAHHDDRGEGLKPRPAISTRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKA3</accession>
    <name>K1VKA3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DExH box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000220">
        <property type="protein sequence ID" value="EKD04595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKA3"/>
    <dbReference type="STRING" id="1220162.K1VKA3"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_4_0_1"/>
    <dbReference type="InParanoid" id="K1VKA3"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000094">
        <property type="entry name" value="ATP-dependent RNA helicase A, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="450"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="652"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="945" mass="103203" checksum="20C726740DB8A078" modified="2012-11-28" version="1">MPPKRRPVNVVRSGNAGNSSKAKPKDDAKDAKGGGKGGKGKDDTEDKPARPPPLFPVGYKSPVTILNEKCQKMGWERPVIETRANAKSSPETFSGVVTLRKRVSKNVYDLDTVRMMPHPPLKVESAAMCKHYLATYALFRFCSHLPLALTLPPTIRPYWSELLAEKSAAPAHRDWEFNPDPFAAKHEVEARQAKREEKTATASKGAVGSAPGSQRGSGRNTPANAPEDGRRGGKHWEDAPEVRMAPAIREMMMRRFPSAVMDATREMGGGSGSSTPNTGASTPALNTDSIQTQLTTLGFRPAHIASCLSALTAANERLHTSGAANNDPLVLSLSILSPLEAAIEWLLLHLPEDDLPVRYRPTSSSQDMVTGAAKGGQNQLVRGWLVDKLVRKAGFPRAAVEAAVAVEERESLALEYLGRRLCGWDEDAGWGLDTLTPADAGEERDILRDEEVLALEALLGERFREEAGKEGARELVISVASAPDDLTLHVVFDSASPYPSAQYPTRPPAFYLTSNTLPAYMRLALHADMLRQFRGDRHDLVGMLEAGSGGVVLSMVEHLETSLPDVVANPPNVADVTKHLVPRPDDDEPEEVRTAPQKEKKTRGKRKHRAATAEQHEAARQQQKRMMADPAYEEMMRVRRSLPAWKERENICRALESNRVLVVVGETGCGKSTQLPQFLLDHEIEAGRGADTNIIVTQPRRVAAMGVAARVAQERLEDVDKTPGTVGYAIRGERRASPDTRVLFCTTGVVLRRLATADADLAGVSHVVVDEAHERGVDTDLLICLLRDLLARNSTIKVVLMSATINEQIFIDYFGGCPSLTIPGFTHPVTDHYLEDLVPEIKYRPTASRFGPKLSEDQKAAMRRDYEKLGLEHEDMRALEILSQNDRIDYGLVAATVKLIVDTSTSGAVLIFMPGVMEIRACVAELNSAGLGAVDILPESGDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKA5</accession>
    <name>K1VKA5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKA5"/>
    <dbReference type="HOGENOM" id="CLU_1428936_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKA5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="20168" checksum="0D410ACB73E05C49" modified="2012-11-28" version="1">MENADRYDDPAVDPRASGPGSGLGVQEGDRAARTDAKIAQNAARGLQSDSAQSQAASATGTAGTAAGSGQGYTSSGLSSGQSTQQGQGQQGQYSQGQQGQQRQGGVGGVGGASSGNNANNEQLVAEGQPFDSSRGQTGAGGRDPYDRPPVEGQFNMNNADRYDDPSVDPRATGPGSGFGLSEGQQARQTDARMAGQGQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKC6</accession>
    <name>K1VKC6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKC6"/>
    <dbReference type="STRING" id="1220162.K1VKC6"/>
    <dbReference type="eggNOG" id="ENOG502QTJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050424_0_1_1"/>
    <dbReference type="InParanoid" id="K1VKC6"/>
    <dbReference type="OMA" id="VWAFWSS"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="37013" checksum="52792D9A844BF252" modified="2012-11-28" version="1">MPDPFGSFGWICQHTALPQCNLLFNQIWQNATDLEVLFPANSTFYHNYTITPSTSPDEPKAAAARRDAGSGLGNDCVIPRVTTQNSLGDIGKLSAWWYELMAATVVVSFVSLLMVFALLFLSKRRRAAVGRSELQIFLIVSSESLLRTDKQGFGFMSALQAVTMSSMLEQASQPLVILSAIHCAAIAAVAWMLVYNGIIATQVLDMGLISAAFFGGTCYVALAVGFNYNDAFFVGAEHPEQLKTNVRAVVIYLLIMIYVTFLKLKEAKPAIILIAGSVLFAGGQVVQFLASQPLCRASHSKVNGSFLMSFAMDLAVGLVFFAWLTITEEDWDDHMWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKG0</accession>
    <name>K1VKG0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VKG0">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKG0"/>
    <dbReference type="eggNOG" id="KOG1791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001591_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKG0"/>
    <dbReference type="OMA" id="MHIATEA"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="663"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1444"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1780" mass="191578" checksum="1B0AEBBC91C85FB6" modified="2012-11-28" version="1">MAPKRKRDEQQADLVHRPEPGTKSFATGKALTAAIVSFHQQIVTPFSQLPLPITHQTVLILQQYLELSPTVDEIFHTWNVAQENERLAESTALLLSQVIRILTPLPFFHAQLVGIVSKLVSATEPYPDLLSRLLQSGRRDQILAGLAVASAAANVEAPDPAQPHTTGRLAGKVWQVIAEGGSAKTLGKALGMRKRNKDGEVHYGQRDPMDRPDIRHLALDLILPLLPMSTLHTHAKTILPQIYSGLSLDPPQTVYRVLKSMWGAISSPPPGIGRRTALVLLDEAAVDSIARLLERPESAFGTPIADVAESFLINTTATPGRGICFPDQGWYLRQDDTDKHDKRKGLHNRILSNVVRKLGNRVVDDEGRVGSWAIKMFTACPELVAGYWAHSALSLEPRLDARWLATMAYVGRIVSLPLPPIETFHEPAPKGSKEAMPPRSLPPAVSTVVESVLPSPLTKSHLSKGLQHQVALVQHVTALTLARGLQKLQKVQAIFSEIASELGEGPDGPWTARARDLEVECRLRVPEVPVIVAFAQKAATLGRPKDEDDEVEPAVAARSAMLTEAALRLFGLYHATLPSLAGEARFDVGKLLVSASSANAERRARREAREGSVVSDSGSVGSVGTLGTVGMGGGFGHARGDVEGFEALSQLHVLRLLASVPGWNWTNKAAGSQYTYLYHILQLHLSTHNLVTRTMTTTLLERLLHPSLLFEHDPTELNIWLDALPVIAEGYGAMFTAQQVYLLSFVDECVRRCTKTAHRYIEEAAAVAPLTPRETASPLLMTMVEQLRAKLLGMHIATEAAAVVANYLRRVLIGLLSKQSNTGFVEAITQRLIEAVDEAKGRGQPRHGLSEVLSQITADLGVINGEKRPALDPETPKLVDEKEYAERSFTRRVLTGAEVGAFDRSLVFSINRANAEENALHAQFLVHCLPKHSVLPLLAATLRTPGQRLLSAIFNAPAVRALSPTPVELVSALSSTSKFDKAIAETYVDGLKSDLVVLAPWIRFLTPAQTAEHLHKVVKKGNVAEVEALSELVRAAPPSAVYPLIPRLLKLGAYAPISALLSDAARSLAPPSVELGADVVSTLLKGGDDALSLLQQVVALSPAAAEALASTDKLDDARLLPALAELETAPEGTASLALAALSTPASDAVHASARAVLLKSAEITLGEIQFSLAFARLAAAISNPNHSYALSALIAKGLQWATRRLSSSAELAGEELVTLSSLADAVRNAGALRVEPEQNDAEPLLLAVSTRLAVDEACELGAIVASRAMLKAGFVRQCLSTLTSSRLSSLSQIRLLHALFNASLYVSAQPNFVEPLLPLYAGTQSAKDRLLLSMFAAFEGQRRLSAASILKHWHAAGGISTRALDAVLSLDSGKVFGTAARFPLRRRVLEPVDRYASSTSPSVVEAEGEKDDYDPVFVLSLLLAALQEPLSGLDWVELLRSNVLGLAVCALASRDGDMRSLAGFVLSVAEKRVSQVAFHEQLQLLHTLQLVRHACTPCTPCTPCTPCTPAASGPSGAEEKEEEGKQPRLPSLTALFVAHALRSLASPSSFLYPLSSRFLLQRPTLDVADVPLLYSSLYSSSENARRERSWLLRLLRDGTRSAADIRILKRRHVPSLLATLIHASSDAGFRRSALGVLEQIASVPDGRRRGLRSLRAWLQDEYDAASLRPEADEVRSALLRILAQTGASAQFVVRIAGTAAPDDLPSLVRIGYKLAKEGAAASVIGALALRIAEMDDSAAGLLFRASLLAPPPVSAARTIAARVATLDTDVGRWARSVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLJ5</accession>
    <name>K1VLJ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal transducer</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_08135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLJ5"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_1_1_1"/>
    <dbReference type="InParanoid" id="K1VLJ5"/>
    <dbReference type="OMA" id="EPRIHIC"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="646"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="869"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1276"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1787"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1787"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1824"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1841"/>
            <end position="1859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1859" mass="204680" checksum="F02F88CE456ABD12" modified="2012-11-28" version="1">MERPTSGGYESLFRDSGWSSSPPPDLNFHLNMDPPPHAAPGARHDSSQHRLPPPPPPRPALDEHGSYVSDLPQGNGSAYHMSSMRRALPTPPAAGAPPAHAGSPASSSFSTHDSHLNNPGRSSTYEQYSLNAPRNRHSRALPALPTPPLRNTASFPAAPPGHQVPSTPGYSSTASDHHGHGAVPQTPPRPLPRPASGLPAHMEAHAFDRSSPYPAQVVNDQSPISIESPAASLSTHPSTIRSNGDQDYFHRGPTTVTPQTSVSSSAHDWKSNQSNHRQQASEVQSCGHDETSAASVLDHYYASESPSYNANDLPNAPSIGVDSSNSTVRTRPTSHISQGNVSDASYPAAESSRAARPTHAAFGSVSFPNARQYADNNERPASGSNPLGDDQPMSAAPSQATSRPGDLAPSWSEQSQEPSRWVQTKLLLHEAGGYYEDEEGGIYDEYASQEEEEEIEVNEIQFFNRAFLSEVAVQLRDRVPRGDHVKAGVTWVGTFTGKDLVNTIRSFLPEFTRETDGDRRFALATARSLQSQLWVVEVDWDDKPVRDSENVVFKFMSEMEDIDVSGELPSGVLTNATKCYSPSCTGEPGCYAPRCPFKTPVNSFISMPEGDAGPSGTAVAVVKSDTDWTEDVDPVILASLTEQQRNRQTAIRRAILLEENYEKDLAAVEKTFITPLMTANPPILSPYHHLEEVVLTLFGNIQEIRRESRRIIDNFAVRLREQSPLIQTVGDIMLEASTDFRNLYPVYSENLPRAEALLAETIQDSPRFASWIKEVATSGDHRLRYLLNLPANHLKEYPKALQGILEFTSPDDPDFDFLTESLSSIESIANLTSLKLWHATLTQPPGGPLAWWNIVPEAVQKSMSKDEIKRQNAIWELIQGEMEYVADLEAIETVFINPLREAEQPIIDRSRLDNFIHDVFHNYRSLLEVHRQLARDLQELQVQQHPKLGVIAEPVLNAALNWHEAYMEYVPNEPIANAKIDEERANNPAFAKFMDVDVFKNPANTGRHGLKHFVNRPTARLLRYDLLLKAILKETTKTELPDHPDISTIPQILDLVATLAKAIDKATAINDAKVKLWQLKTSLDGGKFGPHAVKELDLLNPMRELIHQGRVYRQSEGRGSMSSGSELQLFLFDNYFVIAKQTKASSRNKEGPLRWTIKGKPTPLELLTLGEFDAPPQTRSVGLLKGIRSAGGGETEDKTVYPFTYMIEGQLSGQYALWTDSAKAREEWHEKLQHAKVLRAAVNEGIKIFEFTPLSLDTFYEATRYGATPANSEDYTGPVTCSTPFTTIDGRRLIAVGCDQGVWIGIRHETSSLRKVLHVRGVTQIAVLEEFGIFLVLADKSLLAYNLEALVPTAPSANPARSAAPQRLSVREIVFFAVGQISGRTLVLYMKRKGLDSVFRVLEPVVNRNLDDHQRPQRRAFGNLLSRNSDWFRIYKDFFIPTEASSVHFLKSKLAIVCTKGFEIMDLGDLKGGTIPIFDPIKMRDRPALQELSKKCESAKPLAMFRSKEGEFLLCYDSFGIYVDRHGEPNRDLQAIEWEGRPLETKDIVFHPPYLLIISRSFIEVRHIDTAKLVQIYTGKDLRCTWDGTGGQANALTRGPGADGWGEEFTSQEPRIHICRRGGVATRAGARGMSQHIFELTPTLLLNNPLLNPANTSDPNYFPPAPLDYSSVAAPDPYEAGPSYAPYMGATPGLTPGYQANNMYADRRSVSSSSTHTFANVPQSPAFPTSPAMNMPTAAPMPPMPQNPAYVPPQMNMNGGPYPAPSTGLGAGLGSIGAAHGSAYGSQYAQHAQQSQQGQHAQHAQQGLGYPNLNSAEQSHGHAGHAGHGAHGGSGGLDQAFHQQQQVYNYRQSRSNGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLR8</accession>
    <name>K1VLR8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Structural constituent of nuclear pore</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VLR8">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLR8"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001071_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLR8"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1820" mass="199952" checksum="B44E43D699FF8BDF" modified="2012-11-28" version="1">MSRLPLAQWDPSLFTELQHLLALVASQPTTSLVRRLFASLDTARPWILALTALPGPNEADKKAIAESPITTSEGVEVRVKDELLVTTNTIADNLNVSHLFAAVLALTAVQERPRFPERSDAEIAVYILHEAQTALLDFVSELLRLTEGPDAEVGQPFDDLRIWVEDLLDEKGPNGYIADVAIDEVDAIHTRLDNLVRTQASGPALELVNFRVGSLRYEQNRLAGIVGQLAQAGFLKASQVVKVVKWLKKCTRPDAVAATMLATFMASTPPIDTLSESDPRYETVAAYIQSPKQGIADPSAANKLLRVIVHQVWAVPPLQEAARLHWSLFYLSAVRDNPALPPSVNLDTDGAERKLQEAVAGGAFQFLTGLVVNLDNTPEDPTYALAQRSDPANNQFLYQQLDSLTFTLGTKRNFLRNLKNREEDVSLRRSQAPVANYQAYLALVAVVFKNLPPDSAEQFWDEPMFTGVVLDTRNPYPGVAFWDMLNAIANGPTCASKCYEKLKDTPYSYSHLIRMVDHYIKMMPHLYETIKRTDQISLDPMAEDEFNLMDGWMRLLGTIVKGSALARAAILQHKPSPFTSLFDLVNCDINTELKATVMDTITALVSSRGDTADEAVAKTAVDNYDRVTFADPTLDVRENSRVPAPIGWMQRMEINEEEAGSYPLTRAYIRFLTALVPSTNATVNNALRRGAMYVIDRVMLSKGRKYSQDGEHWELLDAVFAFIEKTLVTFDLTELLSPVRGTASLLAEQPGFLVLLRILSDPNCFTPMADVIDHVVNMSPPRSAVVNSVLLHVLRIYYRILDIQLVFSDVLLLTLASTSGFKRPLSFQSLDHYLLNRLSNIVSIALFVGDNDLAISLVSLKIISSLAESPLLSTTDIFRGEYSRAVNRLAGIIESSDESLRIAQAFYTRLEAEGEDLAPSEIDQEVKDVLSAKSDEVHPIVIRSNILDLLVTGTADSSGPNLAHFLLGFDFRARELGLQDPRAPNSRLSCLGVTLEQLSDQPPMIQLHPVLASKSAQLLYQLFANSITGPPTMAYAESYEAFPARQLATLPRTCPQVMRDVPGLGIASTYTDEVETSADVLVAFLDYEKFILSMTALQTFAFDARGSTSKFIAENLLSDDKEDEDDQRPPLLIDLVSAVDVKFTEADAGDATQNKVLEFFSGFNFDQYKRPGSEWYDVDLLGRALRAQGRHLARQSNLVPSSAQAMGREIDYILRRLSIKNRETEIDIAKGTFLTSWLEVLKVSLVMLFHNVPEDRQEVLLFELLDAILDRLNNDLAPGVLEVLCEAVLVAFTTLANVLSVFDSTNLPIDRLGATLLKVIDAAVKPGTTENARGNLYAAVSQYLQLVPDDPDHPLHKKTVFVLSARKDRFVAVICRDAMDMRDVWKTECYSLLASIVSLGSQSLMTPLTQGGFLLQFVRSIKDREMALQECLSPEPENLHAYWVYESKIAFLTAYAATSKGADDLVEAGIFEVLATCGFIAAQPFSDDVYSEVSAFETVERQHSALITALQLLVRILANPTRSGVQHALSFLHAHCESLVVLLREDAAYITVPGIEESRLIIALLTAVVPKVSQEDLANPTAFGAYHYAVLGLAAKFFDNSWADNLHGETEGSAAAALGLNQIILQYLVKTTSGLKAGQGVPVLVTGVARAPAHGMSAASAPSVGETVELVAELAEAAQDVGAAYDDVAEKLASGDDAPRVDIPGIEGETVQELHDAFAVRLSMINNMIEEALLLIWRHMLYYASETSPVRPEGLSASLAYSKALNATAGGTSGKALQRAAASLRGVLDRLDVVMERDGEDAYGKMLVRRLRELCAGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLW1</accession>
    <name>K1VLW1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03943</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VLW1">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLW1"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001999_1_0_1"/>
    <dbReference type="InParanoid" id="K1VLW1"/>
    <dbReference type="OMA" id="PPCVDEN"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1403"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1526"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1403"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1469"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1535"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1589" mass="177642" checksum="05BC72A5CB0A1748" modified="2012-11-28" version="1">MSDQLPPHNSALPVADEPSMTATKPRRKVRMMGHGPSTPDESEPIVTLGDDHIPGHTRSSSLTGTTAQPRHSSTSQPKLTRSNTYGRSSTASSSYNNWKSKYRDGTNSTPPNTVRHQRSSSVRRTRPVRELAIDMADADGYARALDDWRSDDDDDDELESHPVKALVAEAVRQAATGDGESTPGPHHHGADIAHMGVGQPKSLILATPPPDAAGPDTDEGRERMEWQSMLASVLGGDILRGESSRIGVELPSGKTYRKALGQSLWWQIRARLRNRTEEEERRRVEQRRNRVVDTVLEEIDNFTIKHDGDVSPLDQVAYILEKLAIVESLYPHTHAFRLDKPLYNSEEFQAKVDALSAWYSIVTQLQTQLRTLQLWTGTEDLDITKPNTTKEEPLVGGGGNRIHPLDSKALAHAKDQTDDSTFVDRILKEDSLRRTFEKRIFLDQIAILQNAKQTVIAHLPMFEQLNLPDFQYELLKIVSFPGRLIIEALKTRLRAAERLSDPDLMVIDDMASSFRNSIALAIVIRRQYEEITSVDPESRWALPESFPDSYQDVILKCIKMFFKLLHWKLKSGSKAVYFRETEVLEGEWTFLFDAAEAVEGVDLVVAESLCSLTNKLMVRVINYFENSLHVPIPTDDDGRSSVPAGSPNDTSRQYRDQQPMTTEQMLVWYGKILDAIKMRFRKLQRFARRLYQQFDNSAEYLLEDEDTELFVEQLQESGHFLVYTNVYEEHGTYIFADGSLWERPADVKQLLTRASSLNISPGAMKARASVGLSEYDDESDEEDAQYILLVSPRQSFAWKGAVMTLDVGTKIDYALEDSRIRLVADGPLTRLEYCKMLFTRSFIDPDTETTIFQPQCIVDAQSHLPKVNRELKKIARSALRLSECIIESAAHVRRTLRGAPGTQDLIENWYLFASDHGHRVALHMDNSAWARFSRLLMRLAISWVSFICDNCDPTDRKTFRWTVNALEYAMLMTRGNNILHLTKHEFALLRAKVASCMTLLISHFDILGARSSIEAKKEAERLETLRRMAKMYQRDDDDDCLLPRVPSPTSASKMQMQVDRSLRIPRQERLELINALDQHLAGQSHEQHLIGRVLDEEVSEDRALVFLAASSSNISLRWQQGGFIGGGANGSVYLGFNLDSGGIMAVKEIRVQDITNSPALYKQIKDEADMLSHPNIVDYYGIEVHRDRVYIFEEYCPGGSLANLLEHGRIEDEEVVMVYAWQMLQGLQYLHSKGVEHRDVKPDNILLGANSVLKYVDFGAAKVIIKGNRTMAKTRAIKGGGGGDAGPAVMNSLAGTPMYLAPEVIKGGAGALGAADIWSMGCVVLEITTGRKPWSNLDNEWAIMFHIGIATQHPPLPDPGQMSDLGIDFIQQCLTIDPNARPTASELMHHPWLSLMMELTMQPDQSPTASSVPSLMTTTTGDLQSLDSATTYDLTPQSERLPSGELSHSSLAVSQATSSYHTPESSSSNVHLSGTAPSSESPLKLHMEEIAPEQQPLVHPQQEAFPHQAQQQQQAEYAQLAEHAQLAEQAQHVSPPMPSHLPPPNAINGIDSRLEQLMLSDPQAEHSAGGTPTQCATPVAQRTERAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMF2</accession>
    <name>K1VMF2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMF2"/>
    <dbReference type="STRING" id="1220162.K1VMF2"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_977228_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMF2"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30981" checksum="5EFA022A4A39CB07" modified="2012-11-28" version="1">MRVAIVGSGFSGLSALWYSPHEVNIYERDWRPGGQFQCAELRPDGKAPCWVDVSQLGYDPKTAPNFDFFLRLLGLATQTSTVKLDDALRRAGSFSWDLAFEVARFTLLAPTAPDVTLETYLKQQGYSAAFFEEYLLKWMVPDDLTALSLPVSQVIELHAPTETIEGGAYVQLVFAVAKLTFSKAVVDTICSIVPPENLHLNTEISAVEALPNGVALTESGGRRHIYDHVILARRSAGDAQARWTRDAVRGAGAVADGPQADQRGAAAGELWEDISEADAAVHNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VML5</accession>
    <name>K1VML5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VML5"/>
    <dbReference type="eggNOG" id="KOG1730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_2_1_1"/>
    <dbReference type="InParanoid" id="K1VML5"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="22090" checksum="CCF6C5D1AB99C745" modified="2012-11-28" version="1">MSCADDLTVDDLNANVTSEVLERVSAGEGSNSNLWGSIDRDKVRPESDKDVGRPLGRGALILHIPFITSVRLRTLLLHLPSPGHPHRPHRLRIFCNLPNAPDFNDVESMNPIMDLDVSDSPIRRDSAGRREVDEWALKVQKMANVFSVTLLFVYYVGFKGDAKQLNMDMSKLGQVPASNAAEHNVDAVAEKKGAGYTTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNC5</accession>
    <name>K1VNC5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major allergen Asp F2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000004">
        <property type="protein sequence ID" value="EKD05695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNC5"/>
    <dbReference type="STRING" id="1220162.K1VNC5"/>
    <dbReference type="eggNOG" id="ENOG502RTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1571729_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNC5"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851984" evidence="1">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="170" mass="18780" checksum="543118637EEA9D55" modified="2012-11-28" version="1">MLTSLLLTLGAAASASAGPILIPRELKEYSADVELHSSCNATQQRMLKQALGEMNEVTSFAIEYLEHNGAQDQVFTTYFGTEPEAYPTVIGAYKALLSANKKGVLIRCDDPDGNCHQDGWRGHYRGENATTETVICDSSYTDRLFNSAFCMFGFQLAKDKPSTYWSIDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNF6</accession>
    <name>K1VNF6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">3-dehydroquinate synthase</fullName>
                <shortName evidence="19">DHQS</shortName>
                <ecNumber evidence="19">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="19">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="19">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="19">EPSP synthase</shortName>
                <shortName evidence="19">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Shikimate kinase</fullName>
                <shortName evidence="19">SK</shortName>
                <ecNumber evidence="19">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="19">3-dehydroquinase</shortName>
                <ecNumber evidence="19">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="19">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="27" type="ORF">A1Q2_03503</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19 20">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19 20">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19 20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="19 20">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="19 20">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="19 20">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="19 20">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 19 20">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 19 20">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19 20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19 20">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19 20">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19 20">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19 20">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19 20">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="19"/>
    <dbReference type="EC" id="2.5.1.19" evidence="19"/>
    <dbReference type="EC" id="2.7.1.71" evidence="19"/>
    <dbReference type="EC" id="4.2.1.10" evidence="19"/>
    <dbReference type="EC" id="1.1.1.25" evidence="19"/>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VNF6">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNF6"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_1_2_1"/>
    <dbReference type="InParanoid" id="K1VNF6"/>
    <dbReference type="OMA" id="SWANMSW"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 19 20" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 19 20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="19 20" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 19 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14 19" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 19 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19 20" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="23">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="26">
        <location>
            <begin position="63"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="21">
        <location>
            <begin position="286"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="24">
        <location>
            <begin position="1200"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="22">
        <location>
            <begin position="1312"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="25">
        <location>
            <begin position="1438"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="19">
        <location>
            <begin position="1195"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="19">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="19">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="19">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="19">
        <location>
            <position position="1084"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="19">
        <location>
            <position position="1112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="761"/>
            <end position="768"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EKD02141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1474" mass="158075" checksum="FB32FA1BD48F0124" modified="2012-11-28" version="1">MRGVKFVQIPTTLLAMVDSAVGGKTAIDTPHGKNLIGAFWQPSYIFVDLSFLSTLPMREFSNGMAEVVKTAAIWKADDFASLESRAAEITSAISTKAEGQAGRFEKDRSVPQSLLLQVVTGSIYVKAHIVTIDERETGLRNLVNFGHTIGHAIEAVLTPTILHGECVSIGMILEAEVARQLGILSQVAVGRLTRCLSAYNLPVSMSDRRIASLPAASQLGVDRLLDIMRIDKKNSGPAKKIVLLDRIGKTYEEKATVVADEVIRKVLCESATVISGVPKKSPVVMSTPGSKSISNRALVLAALGKGTCRIRNLLHSDDTAVMMNALAELKGAVFSWEDGGETIVVKGGEGKLTPPPKGKELYLGNAGTAARFLTTVCTIVQPTADAKSTKITGNARMKQRPIGPLVDALREDGAQVEYLEGQGCLPLDIGADGLAGGHIKLAATVSSQYVSSILLCAPYAREQVTLELIGGQVISQLYIDMTIAMMAQFGVQVERQKDASGKLLDVYVIPKTTYKNPAEYNVESDASSATYPLAIAAITGTTCTISNIGSSSLQGDARFAKDVLEPMGCTVEQTATSTTVTGPPIGELRALGNVDMEPMTDAFLTAAVLAAVATKPCLPGREVQGLGPNASRIYGIANQRVKECNRIKAMRDELAKFGVETDEFDDGIIVFGKPYNQLKKGVQVHTYDDHRVAMAHAVLATVVPETVLEEKRCVEKTWPNFWDDLQNKVGIEFDGVELDQSRQASTSGTSGVRDTPVLLIGMRGAGKSYIGSLAAEVLGSEHVDADEVFVQQAGMKVSDFVAQNGWPAFRETETKILASFLKEKSGSHVISLGGGIVETEEARKMLAAYVADGGVVVHIHRDLEDLEAFLDNIGGTAQRPKWGEDFADVYRRREPWYEQCSSHEFINILEPIASQSEKDHHRAMRAECERFFNFVTGRNANRPIVSGLNAQPTAFLSLTFPDITPALANLSTLTEGADAIELRVDLLSPDGQAPLTPKLPPASYVSKQLASLRMASNLPVVFSVRSKNQGGWAPSDDVAGYAALVKLGLRSAAEYVDVELAWPGDVLAAIHAAKRETALIASWHDWTGNMKWDGPEVAGKYAEGSKLGDIVKIVGTATSTADNAQLALFAERTKEDPTAKPLLAINMGAVGQLSRVLNPVLTPVTHADMPSRAAPGQLTAKEVMEARTLVGLCQPKKFFLFGSPIAASVSPTLHNTGFQALGFPHHYDRCEASEVNATVRRVLADEAFGGASVTIPLKLEIMQELSAVSEHAKVIGAVNTVIVRQGAKGRELHGDNTDWAAIHEAALRNLTPSGELTTLVIGAGGTCRAAIYAMHKLGAARILLFNRTRENADKVAASFPKEYNIEVVTSLDTLPAQPAVIVSTVPGASLSMTPGEGIVLPPSLMQHPNGVAIDMAYKPYKTALLEAAEAANWTPVTGIEILCLQGFRQFTLWTGKAAPEQKMRKAAMDKYFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNV3</accession>
    <name>K1VNV3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxyphosphonoenolpyruvate phosphonomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNV3"/>
    <dbReference type="STRING" id="1220162.K1VNV3"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_0_1"/>
    <dbReference type="InParanoid" id="K1VNV3"/>
    <dbReference type="OMA" id="DRIGYHA"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33862" checksum="0CB78E0ED93A44BD" modified="2012-11-28" version="1">MANTNTPLSAAARFRAMLREDRTIVSPGVYDGLGARVCLQNGFDTLYMTGAGTAISTLGMPDLGLATADDMVRNAAMLASLDRNVPVIADADTGYGGPVMVARTRYILAGVAGLHLEDQVIAKRCGHLGGKELVDEATFLARIRAADAARKKVGDIVIIARTDALQSLGFDAAIDRLKKAVVAGADMAFLEGMTSKEQMERAAKELVSSPAENAYAEDQAPTPCLLNMVNGGVTPLIDAKEAQRMGYKFVIWPIFALMSAFNAYDAAAKELKKTGFLKDQGDESGVRGGVREVFELCGMSECVRFDEEMGGKTYSNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP39</accession>
    <name>K1VP39_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP39"/>
    <dbReference type="eggNOG" id="ENOG502TKPR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012618_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP39"/>
    <dbReference type="OMA" id="AQYWAGY"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="287" mass="30736" checksum="C6C81C9CCBC67404" modified="2012-11-28" version="1">MGNQRSPAATEPNDNNRRAGLDEISAASGEQLTSSTPATAMTNVLSFDKGAWDDRELINAYDASLLEFHIHNPGPGSWLDKATAALAKGQPLPGATAYGSSWYTASKPPEKETRIKKRKKNPYANGSEASPAPNPYSASASASTSTPHVERASSPTYRPASPEPADELIEAEDEEPEVTAEGDEEAEDEGGYDEQEWPGYEGAEQEWEAPESAVTAPQTEAPSADAGLAYPPPRGHWDASPVSRETALGYALNAQYWAGYWMGVARYAPAEGAEGEPATKKQKPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPT8</accession>
    <name>K1VPT8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fermentation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPT8"/>
    <dbReference type="eggNOG" id="KOG3596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000463_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPT8"/>
    <dbReference type="OMA" id="YGLEWFI"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2462"/>
            <end position="2481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3175"/>
            <end position="3242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2462"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3190"/>
            <end position="3205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="3206"/>
            <end position="3215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="3242" mass="357740" checksum="DD46B6CC85C0E864" modified="2012-11-28" version="1">MTVLNSPVNWLFIVELVVIVIVTTAFLFYWNRILGLTLGAIIRLGIWNTYNAYLDIGSLQISPLAGRIAFRNVDYRSSNLSGHVVDGNLTFRFWIFRVRQGDSSDNNAKRGFELFVYNRTPAYENIVERMRKHEGSDGVTFTVGGETEGLRQRKTPMSRETTNSSSRRKEETTTEGTATTAEPQLKDSDAANEGFMSRAFGAGLSWAASVLPIEVRVHQGSVTLGSDATPMVVILDTKHANGTIEMSEPRSPYDWYRLSFNFHLQEMNILMRTNHDYTGTLLAHGKRVYDDLLEQDSAIKEEPPSEVASRSGFRGLLKKFPALLDSRFAARPIAVQQPTGQWKGLARYRLEDDGVPVVKVTREERQYAKVTTLLTTSLFDLSYYYDVGGPAPKVSEAVRIDPMDNIGNVDLPPEYGIDLAIHGGSINYGPWTDRQRDALLKAFTPSIFFDTEPKARLSPGESRVPISMVVKIAMKEKMTLRIPTREPSKDWMYDGAHGDVERKYGWLDVVVGANSVIHYDQGQIATKEGYHSYIALYLDELDIASSVNLQSFAVARTCNRNWGIDLTLDTPDLLLMREHINLFTDLAKDWSSGPPSDFHHFVPMHYSFHVSLINYKVHLFINDFNIVDAPRSMDSNAFLDIHGPRIETYAAVASTRYRPEFSSVPFTVDAKDVLVDVRLPSWDTHRTFNPEPSLEVGRVGDITVSGSYRYYATHSPDHQEKLKLTLDAENVAFKALGWVVRRIFCVKDNYFGTFTQFSTMQEFLEKFDHSPDAVGDPIVEKYRPGRSDSFAVNLTVNVRDSMVVMSDEIYGCDKGIVIPVPQLQLDLRNNEYQMDMSVDLAPTYVVACNDLEQCYLSGVPPLARDQDVVFVEGLDIKANRLFGPQPKGTTYVCLWELSIGHISAFLSPEFKDTLAAVGSAVGYNYTDRDNAPSAVYIAKTPPDATFVKLSIQRVTALLTAGTAGVAIELPQGVFIDTSSVASQACRSVQGLGVPCASIHVLRKRDGHKTWQPVGSVSTGLAMDTYKVPPGWKEDAEKQQEFLREQDAATKRVPYLYGEKDDPAYGRHENEIYVPRPRPMEPSWDDETSLYTYEEANDDSSSAGEVDEIDDQAIPRVSRRRRAMSRARAAEVESLYHGGNSSIGDESDTCSSFSSSSASSSNTSLEEDVDPTTILENKLLTFKKIHERARRLFAHEPSTPSPFVQEPQDLFEPLCITEGAVQRISLMKTTVEITPATIEAAAYLAVGLQATSPRPEVQLDQLLTYQVDSLLKNGLPRNPKLFVINAPLAELRLVAGPSYSHPDSVTRVSINSSSSRVLSTPIVDSTKSILEATVGVGALTLTAYRNGAPAGSLALSDIPDVPVPAEPKHNKLLPYTCARALDLGVTVHQEPESLTIQSKVTALEVHSATPGVPVISNILDIWMPVIKSLPKSPEKNTAEALLYDILTQAITTSTSLSLPSFMYEASYGLHLDDQRNIRRDVGWGAIQRLRYWMRQMDQQGQFQPNVIRPSGPSMAKTIVMDLAKVDDGFGQTVETVANIPFLTKVLSKDLQAAGCAPPPTPNQIGVYVRLERGEVRHYGRQLQTDNIAWSMIKIEAASVAYANLKTYVENLPLSNVRSVISVRNIEFDLKDSSFAANEAIIRHIDAHRKEIKELKVVEAVEGASTVVIDVHLDRFKSGLTFGGMRGETSLDHGQVAVTLERRCSNANNCTLELEQRTCIFNCAALESVLAKCPDDPRDESAPVPIITAALRGIKAGMATNFNSQDHLLSFQRVLVGLESLDFDSRPQLKHFYEFVQDWRKRFWPLYEPYWKKFEAMIKKQKARLAASNSPGLPSPPPSGKKPERKPVGDKMIDGFIGKARLQLRGSEKLWLRWDMNRIYGAFRGTPESSKFGGRIDPQTIGGYSQYECIRDKQASIISLPEITGTGNYHQEDDKRHLGMNIGIGMFTGIIKPIVLDRLLSLHQKVGKDVTSIIREMKATWGDKSPKSGSSRFLKAPDSAPPKPALQWSFDAQTSIAGVRVGLRAENVPTTLMFEALDLQASASNVGRPSVEWMAKANHVGLSLRRLREKDRHAMRSAAKPLDGPRSAYMVFDFSAEEIPGNPSKLNIEFKTVHTVMHIAALSEVSDLIKSWSADLTVLREVHKDEVDDVKEEATKVFKKIEGSHMSTVSTGTQESNATAIESWLKSRVLKLGVHGFGIAIPLDEDATIDLSKRYSTNVPALLFSIRAMDLKTSRTETARFKVLNTELQFVNSFDPGQSEQFVGDFHSTDNKMKLPNIEAEAQLTSNASALLVTAHCQATDFHLCLTPEIADGIGKLVDLYELGKGQLEALEREYRAEWGKNSAAESQPESLQSKYDAQVQTTPKAVTVRMSFRFHSGLVELHRPTVAKSKRIHRDKKPEHDLVVLPSVSLWMEYMGPTSPDESARTLLFNAAVHESKNVLRPTILPFFIELVNRIERRAKSRVATNPSSTVTPAPSQIANRSPEMPLLDVGERTDRAMAKVEDAPTGKVRLRVTLRIDKSELRLSCKEDSSAYLDLKWESGGFVAATMLGGKHTTTLAGSVSGVTVFLSHEFASMGQPCVEGGAKDLAFSLALCSEEGNRERGLSIVVDTGVSAELQFATLSAWFEFACVWIENAPKFDLGNKDAPASSMTSTSAQITSTGSTSTVQTSAPCSTAVRSKLGVAALIRFRSIDFNAKLGVTNAHLKLAPVVLRTVTDGEETELDLTVGETTIQAEGEVSGNLISESLKFHTIRRSSRSGASFEADPTVLKMSIDGGDLRGAAFIGDNNIVRFRLEPSRVTLVDNWKEHAHNSKQPVALDFIVDAGQFTGVLKLPSIPRLLEKAYTVLDQISSTKATAAHRSKTFRLKQQQKRSENNNSVMVLNSSTPNTPTAEQKLNPPKVVGTAQLMKFELKGLDVGLFVNDYDDGTVADFLRFYVGKVGADLTRSRDDEQRPVRNLHLHVDFVEWQTCDGRRAAKVERHDQLAGELISAAMKHGYKVVVMLPRMTLDMGSTQEGKTVLYDFDVVWGDSDGDVKVVPKFLGFALKSFRKLHSDIQKLQLDRAKKRGDVRAQSAAALRKARKIDPNVKDPEEEATEGLTFKSRSAHSADYPLPKLRALGETTGDAAAFLDWASSQHIKNAVRMLPEYSHKFVTLPLEEGMDLLLKLYQKQLPDIEDDAASTGPARTGSIAESDAGASKGSAAGSVGRSAGGSVGGSAAGSLGRSAGGSVSGSVKGDVGGEQTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQK7</accession>
    <name>K1VQK7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_06781</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQK7"/>
    <dbReference type="STRING" id="1220162.K1VQK7"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702456_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQK7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RuvB-like AAA-lid" evidence="18">
        <location>
            <begin position="283"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC99027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="393" mass="43211" checksum="F6C3A698B64722C7" modified="2012-11-28" version="1">MGKPSKKALGKRKAPPAPEKSVSSVKRHSSADNQSNKKAKAQPEREVGPTGKPKRRPDQPKKVKLRDQKFIPVPKTEFASDDDEDLMDLGEDDELDIGQAGGFASGLDRNALTTKETKRIHANEKARETFPEKKKKREPSPVSASDISDYDFDSDISLSSDEEGIDQPVASGSDLDDSDLGSDLDSDDDDEEGSDDGSLGSDDEDAFAAEYDALSEDSDDESEDEQPKPKKKKRKDEEAEYETAGRARWAEPESDEDKDHAEVGRLPIKLPTGEYSEEEIKEIVKIRADEEDVKVHPDALELLATMGGQTSLRYALNLIAPSSLIATRRKSPQIEVDDIRLAYKYFLDVDRSAAYAKETSGMLFGEEEVVLVDADKAEAQPAKADGEKMDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQZ7</accession>
    <name>K1VQZ7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_02638</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQZ7"/>
    <dbReference type="FunCoup" id="K1VQZ7">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQZ7"/>
    <dbReference type="eggNOG" id="KOG2457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQZ7"/>
    <dbReference type="OMA" id="CRPGDFN"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="128"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="465"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD03036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="510" mass="55019" checksum="7F53E19D1F723479" modified="2012-11-28" version="1">MPPRKRTRASVSAKREPSLLSDSEISVISVASSDFKPGSASSAASEPESAYESTPEPEPKPKKRKATGPAREKKPTIPVGDIEDGPVVARPHGKSYHDIGDVVANQDALLEWFESVRPEAKGQRAYETQVATVIAYWERWMERWPTIADLAMADIEDVNAAWRGLGYYRRAKSLLDGAKAVMANPGFKGVGRYTAGAIASMAYGVRTPIVDGNVHRVLTRLLALHAPQTAPATIRSLWDKAEALVDALPKGLGKGIAGDWNQGLMELGATVCRPTGPDCSGCPLQTACHAYAEEGEECDLCAPIPGSGDTIPSVTVFPMRKEKKASRVEHEAVCITEWAGPERRWLFIKRPEKGLLAGLFEPPTIPINPAADKLAAALEGLDGLLGTPTRELGTLSHTEVAAVPHIFSHIDMTYHVQHLVLECEAQPPTPERGVWLTADEVEKANVGTGVKKVWAAAYGAWGKTERTGKAATKAKPKPKAKAAPKRKAPEVKGENGKVVRKVMMPIMPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR40</accession>
    <name>K1VR40_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR40"/>
    <dbReference type="STRING" id="1220162.K1VR40"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_1"/>
    <dbReference type="InParanoid" id="K1VR40"/>
    <dbReference type="OMA" id="FKPDEHQ"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26255" checksum="EE7EC5A5DDBFF01E" modified="2012-11-28" version="1">MSGKSKLTPDTLCTPRLPVPEQYAAEAQALGLNVTPAAVKAAFKPDEHQVPSVWQAQRPAAISRELVGGDHYAVYATRGHLKEKGGQLIPNLLERFESEKGYRLFPDTLDTLNGLRDLDIKITCVSNSDPRILRTLSALHILPLLTCPPVLSWDIEAAKPDRRIYEAACKIAGEEMGDGVIMVGDELEAGAIDAGLEARLLRRDGEYSDGAIRHDGEDLKGVHTVKSLTEVLEEARRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRJ8</accession>
    <name>K1VRJ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000265">
        <property type="protein sequence ID" value="EKD03191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRJ8"/>
    <dbReference type="HOGENOM" id="CLU_512090_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRJ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="532" mass="58240" checksum="0115702849AC1FEF" modified="2012-11-28" version="1">MTTASKPAIYDGPRTTSPAPSFLPAACQPTRRSCLPNTSAARRPAVITSSAELLMSLPHHYQPSLYLVQPLLVPQFLSSHTTTMSTERNRESKRSRAQSLPPSSSPPSSPPSDLYDRTVGLLNDWNNALNTDDVSKEASAQAFRSVFRRLTGAARTGEPTASYALARPGNLTETSESSADEEPPADPIEIGLRAQNVSSRSHSSIFNAFEQGTRVVSVDTTTFFNPFIQHETTLYRVAAYLDDEDAVLKRVAVPFPREKALVHRDEDGDIILSPKMIDRTQDRLRESTFNPKNLVLRAAVAPPAKKACAQMVAAASAAIAQSTNDIARATKIIEENTAIFVKMASSAEPANPQFDPLPPFAPAPPASQAGEAGSSPTPMSTWAIETVASIHMLTRKPNAEYDKILKSFLDGRRKGTFIRFVSGGSATRRVAFLGDQRLEDVIDISVPLPEGELDKRKKFRGVHSGYRLLHVHELPDGSVVCDPDFVKMLVSTEGGRERFVYGVEALEPDNARRWRNLIRWLSLTSYDNATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRX6</accession>
    <name>K1VRX6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000295">
        <property type="protein sequence ID" value="EKD02247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRX6"/>
    <dbReference type="HOGENOM" id="CLU_967054_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRX6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="32505" checksum="1E9DF1A75D915EF9" modified="2012-11-28" version="1">MEHGSSWKVRDRVTGDSMSASSVLNECRSTDAAAWLHLESRYPNSERTVRVLGDHLGRLPKLQRIDAGTVVFFGGSVIPGPAEQPHIVNNAEPSLEVERIVLNVPIHGQRFYSDDGHDSLQIGRGAGMYLREVVYVFQPVDEEGNLLEARSEFASKDKSKRGEIPDFSDDGDWIPICDNLTDLLDHGYAPQRITFVGLPPRFYLGEELVDPAACLRTHIEDLAHEHAMWDYVENHVRFVSLPEYLKGPNAKLETSMPGWPKRLPRAIKDASRIVRNPIFGDSEQLYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS56</accession>
    <name>K1VS56_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000249">
        <property type="protein sequence ID" value="EKD03431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS56"/>
    <dbReference type="HOGENOM" id="CLU_485870_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS56"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="561" mass="60708" checksum="A80385A04212B4FF" modified="2012-11-28" version="1">MPFFRRPTNQSNSTAYGGSTSTVPHYNVYSNRRYASSNYPMSSASSSCSDAESQLSDLAYLQPMKKFNGRNDSDSGCSSASSVKSGRSLKQKLSRAFSGGRRPSVSVPTRTETIPPVPKLSAEYLRAMASRSPSPLSPAATTVYEENENNSTPRRCQTSMSNRLPSSKSNNSIFSYARAVHGQPSQPSLHPQLTIQHALPRHVPLASPTQQTPKAGDRRSTSSRAGARISHQRHGSMPAASELSRLSAEQKFVFTPKRYGGIGRQQPPRSRSSSFDPSVQHMQRIPSPSLASAMGSRPSSPESAVSTPFRIRRKPVPSFQPVPKDKGVAGEDTDASSMASPLLKNVKVEPPIEEMLDLDLEDKAEEAASPEAEKSFRRELDVLFEELLDACQSLGADTAPSSPTPRTLGSGSVTAPVTPKKALAMPTLTPPSRRVGLGRGSPSPHRAHSPAQSTQNTDGPVSPLDRAKSAVCRKSDDHHFFGGRVEQVTPRKTPKSKSSKPTTPSRVRHQIRQIERIMSEQASPESSSRIGTPLKSKPTLHDAADNRPRGDFEPPLHRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSB9</accession>
    <name>K1VSB9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSB9"/>
    <dbReference type="SMR" id="K1VSB9"/>
    <dbReference type="STRING" id="1220162.K1VSB9"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1031294_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSB9"/>
    <dbReference type="OMA" id="NANCDLC"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="270" mass="30797" checksum="4F77350BC571BE4F" modified="2012-11-28" version="1">MSTARQTAPSRDGAGSTATAANVQEKTTRGSQANGQRRVRFNVGAYGVVVSAIHRPTNSKVAIKKIAPFDHSMFALRTLRELKLLKYFAEEGVSENTSSPPRPMMRSTKELLETDLHRVIRTQDLTDDHCQYFIYQTCRAIKALHSAESACLKQRATLTPVIHRDLKPSNLLLNANCDLKVCDFGLARSTQTAYPKEQGFMTEFDPRKRYTVDQCLEHPYLEAYHDPEDEPTAKPLDPHFFEFDLMKDDMDRQQLKQLLYEEVVSFKRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSH7</accession>
    <name>K1VSH7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSH7"/>
    <dbReference type="FunCoup" id="K1VSH7">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSH7"/>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSH7"/>
    <dbReference type="OMA" id="AYDHKES"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="365" mass="42116" checksum="DA12F4D15851A9FA" modified="2012-11-28" version="1">MNFFNRNRQRSPVDSVRVLKDYIQRLDAGSVDQRKKVSLDVPARAATVEHSWNTTEECSRLIGTIKACLCGEGDGDHSPETVTLVANEIYNQDLLSLFVARLPKLEFEISVGSFQCSIHLDIASAEMHGTIRETAANSYQARKDVGHIYNTLLRRSIGSRLPTVELIVNKPEIIFATLRGYADAEVALNTGMILKEMLRYEPLAKILLYSDHTSRTQHLASRETLTRHKPMVAAYLDHNYDRFFNMYNTLIVSNNYVTKRQSLKLLGEILLDRANYTIMTRYIASEANLKLMMNFLRDRSRNIQFEAFHVFKVFVANPNKPPEIARILRRNKDRLLVFLKDFHNDKDDDQFNDEKQFLIAQIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSJ4</accession>
    <name>K1VSJ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSJ4"/>
    <dbReference type="FunCoup" id="K1VSJ4">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSJ4"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018152_1_0_1"/>
    <dbReference type="InParanoid" id="K1VSJ4"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="687" mass="78485" checksum="255A67FC3E83E85E" modified="2012-11-28" version="1">MAMPGTETIRFRRPTNVAGPTKVEEKDQFGNAAPSGWKRRHQGLLQDQVGRQRNGPVVPSLSFAFRLLMLVRFTGAMYAIISDCDEVFNFWEPLHYFQHNSGWQTWEVSAQYAVRSWAYIVAHWPFAFLGPKFLGLGERQQFFALRICLAAICSFAEAKFFRTVVTEVNERVGRYMFFMMLFSAGMWNASTAFIPSSFVMYTTMLAASYWFHPATSTPTGKRRAFLATFFTALGAILGWPFAAALGLPFVFEYLFVAGGEIVAPSNRIVWGSGRMNTLIRAVSWSACLAIPVAAFDSWAYGRNTFPTLNIILYNLFSKGGPDLYGTEPWYWYIANLFVNFNFLTLAALVALPALLFTYKFDFRRLGKTQMKPKEGESSPYLLLAIRLAPFYLWFIFMSLQPHKEERFMSPIYPFLCFNAAVTIYLVKGWQETLFINLTHSPYRASQTSMFSNFALAAVLLPCLISLGRIAATLKFYQAPFNVAYYFQYTTLPNVLSDMGYEPLPLREGRSGEDVQHEWDLTPLQNMTHPINLCYGTEWHRFPSSFLVPEGVNTQWIQTNGEGMMPRHWNPSGPAGAWPREETRVVHFGRFNDMNEPSAEPGAYLPVEQCHYLVAVSLPSQQFSEKEPDYVHDDAWNREFCTTFLDAASSRPWSRFLWFPWGVGEKGRVYGEYCLLRQKGVEINTEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT48</accession>
    <name>K1VT48_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT48"/>
    <dbReference type="STRING" id="1220162.K1VT48"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="InParanoid" id="K1VT48"/>
    <dbReference type="OMA" id="AYTYVFA"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="571" mass="61051" checksum="C2027708614CAE3C" modified="2012-11-28" version="1">MPTLHQYDYIFAIGLLFAALDAYNIGANDVANSFATSVASRALTMRQATVLAAICEFLGAVLVGAKVSDTIKNGIIDLTLFKGNAGIEMLGFTCALVASATWLMIATKNSWPVSTTYSLVSALAGVGVATGGGEAVNWGWNGGKGLATIFAGFGVAPAMSGGFAVAVYLITKFAVLDRANSVIKGLYLSPFYFFTVIAVLTMSIVYKGSPSLNLDDLPEVTVALAIVLTALVCAILAAVFWLPYVYRMVVKKDHTLRWWHFVYGPLLWKRPDPEPLPEGEAGNTLVKDYRVVGRDSPQATPEGQVEDPEKGGADDKNATTPEIEDTHVCTCRPVVGLAEVDQKEETIGHKLHPRNVWIWIKALPRRILSGASVDIHERQAQSGESERLKKIHAIAHQYDNDTEHLYTYLQVLTACVNSFAHGANDVSNAVGPFSAIYYIWSTGNNLGKNVPTPTWVLVFGAAFIVIGLATYGYKIMAALGNRLTLHSPSRGFSMQFGASITVLLASQYGIPVSSTMCLAGATAGVGLASGGPKAVNWKAFGWIVLGWILTVPVAGTAAGCLMGLFINAPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT77</accession>
    <name>K1VT77_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT77"/>
    <dbReference type="STRING" id="1220162.K1VT77"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366812_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT77"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="82801" checksum="BE09FF4A02A5801F" modified="2012-11-28" version="1">MPLGPFLARSKTEMTYLDRVFDCHHSTKTLPRPMLRRLSSSVHTAVAAGRRPIRAEAFPNEPSLSFLKARLVAALNPPSTSTHDRRPEASEVLAAAVPLLDPSKRNVLDPYLRLIAVELSQHYKMTPIPLEEIPNLSAALAACCLSPHGISKQRGISNDKVATINERYTHWLLFESRSGDVERINAVLDSFESQVTLLEVPRLTVPLAAAWAALRSAAGRAGEPTLSVQAPHSSTVKGYLSKKEVLTEENEAMVMQMFPELNSLTTLPSSVDTLQTVLLGFRERDKIQSIADMWKMWCDNPPKDLSRGEVLAKFLHAVRWRPTAVTSPEDREILKQLGKEIMARVPTPTPLPVLQVLLSTAGDYEHDRPKDKRNVLPAAMKTWREAKTEKVPIDLKTYMTYLGMLGKYHADVPLFKTWEELVADERCKKLHEKELAEGNKPGKAVDTESWPPVAALNQVLSAAYMIGGDATARADALFEAAVEGNLTTKPDIITINTALRFAAHVADVQKMNAVIASAGKLGLKPDIVTYTTLVQGLLRANEHDLASKTLDAMKASGIEPNERMAATLISDLAADGTRDGLRAAEDTLRDMRRRGVKMTVFIWTALITGYFRGNWVLDGFSAMERMNKQGIRFNIIGYNALLRVVSDGERSARNDYRRSTSQDLENAQVPLALKLFRQMLSEGIVPNADTYAIVLGGFLRTRRDAEALEILQDMDSRGFKTNKRALQQLVRQARAIKRRARHTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTK1</accession>
    <name>K1VTK1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LAC2 isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01909</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTK1"/>
    <dbReference type="STRING" id="1220162.K1VTK1"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304653_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTK1"/>
    <dbReference type="OMA" id="CANYPSI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13904">
        <property type="entry name" value="CuRO_3_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852406" evidence="8">
        <location>
            <begin position="17"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="222"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="345"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="619"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="861" mass="91004" checksum="117F0CE48CD27ED0" modified="2012-11-28" version="1">MLARLLALLLAGPVLAQSDSPSASNTEVTTPVTTGPIASFVSEVLTEPTLAPSPSLTATPANGSAGSASDINEGGSDGDGGASGEVDITRTDITTPVTAGPIATFVSSVLAGAPTSVPSGALRLQTVSVSASAATSASATRASSATASDSPAPASEPIASLNGSVSPSSSIASSAAASPTFSYPQPPLPKVTVRTPPQAFALNSLTQRPRERRYTLRLSYAAGSPDGFLRRMSVINGQFPGPLIQATLGDTLAITVINDLDTPQSVHWHGIRQEGTGYYDGPPGITQCPIASGGRFTYRFKCTSYGTYWYHSHYGNTLADGLYGALIVYSPDDPIKRWRDFDNEKVLFVSDWYDDQSDTIVNGLHNLSAGYRGQPFATMPDSVLINGVGQTDCATAQAGVKCTRTRPATVHARLGSRLKLRLVNPGSESLIRVSVDQHVLQLVEVDDTPVRPVYMHEVSLAVGQRVSVILHLNQGGVRDAFWIRARAAAGCIFRGFEMETRAVLRYTDRFGLTWSRRPPTSAPWPDRAATLAPCLDSDQEHTLVPVEKEPLGPVSARGRLDSMAGRFVDPVTGADFLGFGIGANGGQRVTYTNYINDPVLKQVMDGRALNSSHFAHLSLNGSRNQTADILLNQLDRALTHPFHLHGRPFTILARGEGSTTLEELGKVEMNPPNPLRRDTILMPNGTWVLLRVPLDDPGVWPIHCHLGWHLANGKLGVVVGLLNNGSGVPDTADMGSTSTTSPSANSTVAAPLNLSASALPSSSNSKGGKEKGTDKSKGDGHVKPANGKGPKDKDDSHGHGDAKPAKGDREHGQKGTKVIEVTEDTCTHKNTASLYILRYDVNDLVAQTSLDGGACLDESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU05</accession>
    <name>K1VU05_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU05"/>
    <dbReference type="HOGENOM" id="CLU_1074373_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU05"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="259" mass="29581" checksum="3113CB265687E4C4" modified="2012-11-28" version="1">MGDSKDTHGFDNPRPIKQRQLKLEDLENYPIWSFLFQDEELAIAVIRRGERLYLHNLFLADHGIEAAGQCYVRRRLVCQGDADSDAPGLSFAVPADASSLDYVFSQAHNIYLSAMTLASRVAWCQLLREVQLPRSCTINTYHQCIMPDVINTPAVDTHRVHFLNPCVCEFAPIIGSGCRRLVLSMLIGHRDEIVQFEPATAQMYKTGLWAQSFIRDEFEEIVFEHFEPSQFFYLCGYYGAQMLSATEARRGTQKFTLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU57</accession>
    <name>K1VU57_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU57"/>
    <dbReference type="STRING" id="1220162.K1VU57"/>
    <dbReference type="HOGENOM" id="CLU_1040814_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU57"/>
    <dbReference type="OMA" id="RMTWDIT"/>
    <dbReference type="OrthoDB" id="4935642at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852416" description="Alginate lyase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28144" checksum="B6F02A46F4107FF2" modified="2012-11-28" version="1">MLTAILSSLVFTGPALASSPLSFWKAPARDGGYEKISAKFYVDPSSTWKTGYYASTQASFAGHDVQYFGIQPREGQYSGHLTYSVFGKGSSVGDPARCSGGADGGAGVSCSLDGINLNKGEWYEIVSAVVEHGDKGRRWNGTLIDSQGKQTYIASFWTDDSYGPLSGDGAQWLEWYYFNGIYETTTPEQRDCQPPFTVKYERPTLYVGDQQVKAKDTGKDSKWTIDDKCAVKANDPNYSVEHHDAYVQINGGIHSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUJ3</accession>
    <name>K1VUJ3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_02626</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUJ3"/>
    <dbReference type="eggNOG" id="ENOG502RE1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_4_0_1"/>
    <dbReference type="InParanoid" id="K1VUJ3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD03177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="334" mass="35702" checksum="DA1A5F7269546CD0" modified="2012-11-28" version="1">MSEAMTLNITGSQAIDRALGAVIGSAAGDALAIPYASSPALLQKLQADKPVPLASAGQWQEGEWASSTAMDLPVLEALVKKMDPASDDGQTFIAERWINWSGKGMDDRLKALFADTAERDVNKPDEGKTATGPNMANAARKQDIKKWGKSDLNRAPARISALALGYLGDGQEKALVDAAQKLTDLTQPDEDAREASALVALGIRNTILTGDPKWSEAIEFLGPIRKNVWTRRITDAEKSKVEDFNDNKTSHGAFQAAIAALNGAKDVQAVLDRAVRGGGESDRVAAIAGALAGAKSGASKLPAWWQKLYGWPTKVDAIPDQVNSVMTRYEFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUM6</accession>
    <name>K1VUM6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Telomere length regulating RNA binding protein, Pbp2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUM6"/>
    <dbReference type="STRING" id="1220162.K1VUM6"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354191_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUM6"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="169"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="284"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="793" mass="85384" checksum="6EB7CDF0B65F026F" modified="2012-11-28" version="1">MTDSSSATAKRPASPSPLSDNTAKRAREASSASPTKSDTKKEKMDESSTRESGSGSEPGPSTGATISAPPTSIPATPAKPSEPPAQQISMRALIVTQDASVIIGRAGAHVNEIREKSGARVTISESIPGNPERILNVFGALDAVSKAFGLIVRRINDEPFDVASVPGSRAVTIKFIIPNSRMGSVIGRGGSKIKEIQDASGARLNASEVMLPGSTERILSVSGVADAIHIAVYYIGTILLEYQERNPGPHSGIGTYRQQPQGMAAAQPSFTGVAPGAGGASAPGSQTQQIFIPNSLVGAIIGKAGSKINEIRAQSQCQIRVTEPGTAPGPGQPANPDERLVTITGQPVNINIAVQMLYHRLEAEKAKAAGMGGGQPAVATVNVNEIPCAKRASQPSASTGHGDLCELVKEAVFLFLFLPITLTLPRQSTMSKAPPLLPFHADVLTEVFFFLDRKSMARCARVNSAFYTLAVPQLYRSITIDLESDTETLVNYMRANREEIMAGTVSMADAPWVLVPTLVELAKPRLGIDLKSLVRHVDLDTHQISTCEGTGNILPSLSGLKSVRLTLHQSSILQDVQYYSLHPWDFAACCVLEEISIPKLVVRNVPLLYARASQNLAPKRALRDTEETVFSLFPDQAVVGTNMKFESASCGLSGILRAMPPSTKRLTLIFWTDPTNAEHGPGSVWKPSPRPLKDGEGSVIETSWVGRFFAQLGRFAKVYHTTFTIVNVGNVDPTAILEDGDEDHSTEHVQEVVEDFVRRSVGEDKVEFRQMRGYMRSREAEGVFDDEEFRLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVU2</accession>
    <name>K1VVU2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000201">
        <property type="protein sequence ID" value="EKD04666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVU2"/>
    <dbReference type="STRING" id="1220162.K1VVU2"/>
    <dbReference type="HOGENOM" id="CLU_419314_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVU2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="71841" checksum="FC9E9CAA258D3B08" modified="2012-11-28" version="1">MVTAPLTGVGVSQGFVPHQMFHLVKRRTHAFRDTVDLVHQVFADPVTGVPSPVAFHHPDQCARQPHWYDQAKGGGYGRVRELVVSSAYLLQQGDDNDLVVKLLDAAHYRNTIDLVHQVFVDPATLSTYPVHRAYCNSANLSSVEKLTTIDMAQTIEDALAGDQEALDSALNSAPVLDTSIASMIRRYPPAPDEDAQVDELKLHTPDCLRVARQYEYGAEEELSGGPLSDLAAQGSLWAGRHLHKAAFRYWRQSAFPPCVYHRGTSAPSFAVSPRIRSQIFQRSGPYHLSDALSASEKAQVIGKVSVFEEAMKGDKAALQEVIDGAAVLPSSLASMIDRYSPVPGEDGAIDELVANSAGFLRVVEQYEQVWNSLRARAVADFTGRITEKSATEREIWRLCVRALHRAESQCDRAFGHQPENSPMGVLFLMLVHWSRHGVVDMFTGVPFDIGGSPHSPRGFTMMAHQVHNAPFNLGFDRPYPTDLSQYDGARFLPPPVVIEIIRSARTFVGPLLQNLGLAVSTTEFTFGDSLWSELEHNGLADFEIEHFYDVPAERGLAIRDPKSQYLVNATHSDLPEGSARDLVMTNSEHELQDLLRAIGPVSGGRKTDLAIRIQQLSVLEDELLDPGGVGKSSRMSADQEGSSSKVASTTWSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVW0</accession>
    <name>K1VVW0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVW0"/>
    <dbReference type="STRING" id="1220162.K1VVW0"/>
    <dbReference type="HOGENOM" id="CLU_2225038_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVW0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="106" mass="11706" checksum="9679CD0EA0CA5665" modified="2012-11-28" version="1">MDLCSLSIDITIQNPNNLKARMLEDYDYRKNEKKVGGMLRYLMSILTPDDDLADDPLKGINVDAAGGASKVLKMLAEKPSAESTPPPQKEKEGVVAKRQEEQLACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW25</accession>
    <name>K1VW25_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW25"/>
    <dbReference type="HOGENOM" id="CLU_1332764_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW25"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="22432" checksum="70E59F3A9524D2ED" modified="2012-11-28" version="1">MAAVAPQAQYTNVHVPSPHSSMPGRTPQSSPVPSFRSVRIKSPAPSGRSRPPSVSSMSSMVPTPRIPASPGLSPHTISRASPCPSLRSSPRLRSPEEHYELLERKSAEVSRSLLEAMEDLDAKDSIIADLHHTIGDLTQKLVDVRRENVQIVKAATPFTDAARCAGADAENDGEKEALKRRVAQLEVENETLKRRMDKVSVVRATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW64</accession>
    <name>K1VW64_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW64"/>
    <dbReference type="HOGENOM" id="CLU_1129758_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW64"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="27232" checksum="04C743C18A86FE25" modified="2012-11-28" version="1">MKQPLLHAHAVPGTPLLRVFLCSSNGGPLLQGKESLSRDPEALKLIARALPLPLSLERAPRAEGKHPTHHHPSDHRASASDTAVTTKLTQPSSKLDPFLARSFAWPVHSHSVSRLSSSILSSKPRSLLDTRLRVHHRRITHNSTLLRLDRLVRLPSYRLVHEADRPPHPPSLSPADVSPSSINRHLISHTYHHQNTHRHPSSISTLLSPSPKHRIPYARPSARASTLDSLALSLSCITTLTHVYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWQ8</accession>
    <name>K1VWQ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWQ8"/>
    <dbReference type="STRING" id="1220162.K1VWQ8"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_17_0_1"/>
    <dbReference type="InParanoid" id="K1VWQ8"/>
    <dbReference type="OMA" id="GNAMPPN"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="98"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="210" mass="23162" checksum="38ABBE068C625775" modified="2012-11-28" version="1">MEGRKGSCGRLIPTYEARLVQEDGSDAPEGGRGELWVRGPSVMTRGYHRNPEATAKTMNGDWFMTGDVAVRDPEGWYTIVDRVKELIKYKGFQVPPAELEALLLTHPDVVDAGVVGVWVEEQATELPRAYIVARPGLIPEQGREEARSKFGKEIAAWVAGRVAQHKKLRGGVKVIDAIPKSPSGKILRKDLRVVAQEEIKREGLGARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX28</accession>
    <name>K1VX28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX28"/>
    <dbReference type="STRING" id="1220162.K1VX28"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604366_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX28"/>
    <dbReference type="OMA" id="MSEGSDM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="46"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="474" mass="55315" checksum="B5F72C6A249D1C0D" modified="2012-11-28" version="1">MNATGVLHTIHHAEPAHLLRPYGQRQAPGARCGKLNDPLCSADDSSNSLPMSNSSFRALCVGHQGPDGLQGYKGSPIHRVIDGFMIQGGDYTKRNGTGGASIYGGMFKDERLEGPGTEVDKEGVFGRVVSGMEYIATIGKLDTDERDRPLSPVIVSHCGELELRRRARTPSPTPSEDSEEEYRRRKRERRERKEKEREERRRERKERRRDRSRSPSRRDTEDREDRDRSDRRDRKDRKDKKERRSGRRRSDSRDSRDSRSRSPFETLSELDARLLREETERLEAERKAREEEKRARIAAERERAKESGGIVYKGRGTMRYRDPDARWDTWGRPENYNARGQDTRSRFRRRDGGGDRWERGMDVRADRFERERGDRGGRDSRERFDRWDHGRRGRDERDDKRDDRREEEERKKLDQDLDKSLAERISLNYEEKPAEPAEGKEQRASAWNAARRASPSPDRGARSPSSDMVMDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXR2</accession>
    <name>K1VXR2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXR2"/>
    <dbReference type="STRING" id="1220162.K1VXR2"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_343608_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXR2"/>
    <dbReference type="OMA" id="STACTTH"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="236"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="537"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="824" mass="90248" checksum="560CA085D780F994" modified="2012-11-28" version="1">MVCPFARSSDRRRRAIRVDHTGRAVRLEAPLMLRLFHELKFESIWHMHELGGRTRAGTDRAVHVLEQAGCTLRMGDELIAEGSHKPSSLSSILLITDGYIPSVDTHCPYHPPPLLDINPPALLDVMKTAALIAVLAALGSVDAAVHRMKLQKRDPASLLDHDVAKEVEFLMQKHAGAFMQDTAQKVLGGFGGAGRPLRTNKGDGERLWAQMIEEENENALKGGHGVPLSNYMNAQYYAPITIGTPPQEFGVVLDTGSSNLWVPSVQCSSIACFKYDNSQSSTYKANGSEFAIRYGSGSLEGFVSEDTLEIAGLKVKDQLFAEATKEPGMAFVFGKFDGILGLGYNTISVNQIPPPFYNMIDQNLLDEKVFSFRLGSSEDDGGECIFGGYDKKWSDEKPIYVPVRRKGYWEVELEGIKFGDEELPLENTGAAIDTGTSLIALPTDIAEILNKEIGAEKSWNGQYTVDCSKVPSLPDLTFNFGGKKFPIKGEDYVLGRPLRTNKGDGERLWAQMIEEENENALKGGHGVPLSNYMNAQYYAPITIGTPPQEFGVVLDTGSSNLWVPSVQCSSIACFKYDNSQSSTYKANGSEFAIRYGSGSLEGFVSEDTLEIAGLKVKDQLFAEATKEPGMAFVFGKFTVSFGLGYNTISVNQIPPPFYNMIDQNLLDEKVFSFRLGSSEDDGGECIFGGYDKKWSDEKPIYVPVRRKGYWEVELEGIKFGDEELPLENTGAAIDTGTSLIALPTDIAEILNKEIGAEKSWNGQYTVDCSKVPSLPDLTFNFGGKKFPIKGEDYVLNAGGTCISAFMGMDIPPPMGPIWIIGDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY44</accession>
    <name>K1VY44_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY44"/>
    <dbReference type="HOGENOM" id="CLU_577709_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY44"/>
    <dbReference type="OrthoDB" id="10684093at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="473" mass="52187" checksum="1872A7F6AA492E56" modified="2012-11-28" version="1">MPPSDSEARANEKVAKDWHTAPHPLTTPFTAGSDQAFTAAAFGPAHYAQEDTSLNETLWSLWPISSPEELEEVLKDAEEKRDELVLILVGADTRRLPAVSKNGSFDKDKLRAGLPQAERVRMATMVRLIGSLHAALNTVGRLEYGTLVDGQSPYILLKTRQTLLDVPPLDRAIESARRFKKEGDVSLEHMMAKATMLQYGDLETVMQMAAQHFSAEVNELAGAAVGKYCSALLALWPWTASGLIMSPEVAFSSGIAELENELWWDIGLTCYRQFRIGPDCKAGDDTFNATFVFAMYGRLANLIPVHTRYVPYKTLHRALGCEHLPRRLAGNGELTPGASLNGLVFSQFKSDQWLSELQDGDRLNDLCIPGAANAPDAWAHGSCDTKHKGCLGIGFSLHEKLGAGDRVTRLNEEREANSDLLAEESSSYYESLKAKSEVKGRWSYDKEGKKTYGPKTADKRKAFYLPDGSVEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYB9</accession>
    <name>K1VYB9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_04064</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYB9"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261916_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYB9"/>
    <dbReference type="OMA" id="RVWCTYR"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="14">
        <location>
            <begin position="466"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="768"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="842"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="983"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1271"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1001"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1220"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD01693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1295" mass="140441" checksum="1AFC523E8F9A033D" modified="2012-11-28" version="1">MPDSPHDGPAQLAPPSHSTSMPPSSYQEAGTRSRKKEKLGLFRKRSTPTPDPIPPTPPVDDNDEWLVEGESRNGHVNATVSVGREASTLSRSAELLPADDAQTSASTQSSASTHLSSAAAIERRPEKRLSKSRTLAKKTSRLFQRTSNGSHKHHSEDDAAVIRHHQQSGRQSSFSSTASETGSSRNKHWSLSRASTNSSPRASPETHQPSSWHPSTTFTLRRSSSVSYHSHSKPPSEHSEPTAPQTTPQGLRHRDSAQFHNSATGGGTIRGSNGSTLQRADTVSSRMSSWLTNIMPTSNGSEAAAASPAPAPVPPVEQGTPSQPQQVSTSSPLRRPQSIAASIFSAARNKAASGMRYLLDSDAQPDHCQDTMWVMGVGHPGWTPRLEDTPIPESEVLATPPRVDQRTIKGKENVQSTPPQARGLGNIFGSSMNIGAQANAPATPPSDSGVTRLKKDRPKEILTWPDQFYDDFKSRVWCTYREQYAPILTMPHDQLIPNADAYFGAFAQNEGLSHSQTMMPSRQSGGGAWGWVKGGERGLTSDAGWGCMLRTGQSMLANALIHLHLGRGWRVPTQKPSVHPRTPLELAELEAYSTYVRVLSWFMDDPSPLCPFSVHRFALIGKELGKEVGEWFGPSTAAGALKTLANSFPPCGLSVVSAADGSVFRSEVYQASNLPTDWTTGAKPSRPNSYHRMSWGGKAVLIVIPTRLGLDGVNPMYYDDIKSVGIAGGRPSSSYYFVASQANSLFYLDPHFTRPAVPLRVPPASAGLPPVQVPRSAQRTPCTSAPHSEVSADILEEREEEEHEDDVDSISDDGLGDDPSIPRPRVDVVDVDHAARFETRHPLRRDRRFNPSQPLRVPSTPPPRGSVDLDEPTTPTLSAPHGSPQQSPFAPPATHTRYSSTDSSIQSSPSRAASALPVDPQTSWYASAYSETALKTFHCDRVKKLPLSGLDPSMLLGFLCTNEAEFEDFCERVSRLPHKFFNVQDEPPTWSDAESGLESVSEPDPDSDGEFNDDEFEDDGDMEFGRMGHRYVSNATVVPRYSNRHSQHSHTFSTSTTSSHGGNASHDAIGALSCNSSEDFDSGSVETPMEHGSRPLPSIATIQLDDDESFEQQQHELPPRLPSSQTLRAFPRLSADGDSPQHHIIPPPRKRSLTALSSKGPAGVPSKPLPVIMQHADPDTTPKQTHQKSSYNFPKDETVRDLASTARGDSPEPKGEESEASISAQRHVTAQSGAIPFSATVPSLSDEGGEEEEDSLVIIDKDLDEELECTRNSAGGVLDRTELESVPELSPVPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYF0</accession>
    <name>K1VYF0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYF0"/>
    <dbReference type="FunCoup" id="K1VYF0">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYF0"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="InParanoid" id="K1VYF0"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000010">
        <property type="entry name" value="Heat shock protein DnaJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="398" mass="43294" checksum="579908854241E61A" modified="2012-11-28" version="1">MVRETDLLGVAPSAGPDEIKKAYRKKALKHHPDKGGDPELFKELTHAYEVLSDDNKRAVYDQAGKEGLENGGGMGGMDPQDLFSQLFGGGGGGFFGGGGRPQGPRRGKDLVHRIGVSLEDLFKGKVQKLALSKSVLCPGCDGQGGKKGSVKTCTACRGQGVKVMFRQLGPMMQQIQQPCTECDGTGEIMDPKDRCKQCHGKKVVSERKVLEVHIDKGMKSGQQIKFQGESDQAPGIVPGDVVIVVEEKPHERFQRKGDDLYTDANIDLLTALAGGEFYIPHLDNDALKVIIAPGEIIKPGSLKCISGHGMPSYRHHEMGDLFVRMNVQFPESLPESAMPLLEKALPARPPQPKLDPKLHIDDVTLEEPNDRQRRSAASNGDDMDEDDDDRPGVQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYK4</accession>
    <name>K1VYK4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYK4"/>
    <dbReference type="STRING" id="1220162.K1VYK4"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312648_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYK4"/>
    <dbReference type="OMA" id="NTHTGMS"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="344"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="800"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="861"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="935" mass="97252" checksum="839AAD8628D5FA8C" modified="2012-11-28" version="1">MSCALISNLATPDLLMKGEYDLAGKPQPEGHGASSTGAGAGHEPTSTGLANLLSTAAPAVQAGSQVPSASPSITSASLHTSTPVSSSMSVASAPPGTAVSTASSSYTMNGDSKSMLATGTPILGHSGSAFSGSANGVNASGTSSPIKTPQPRWVGAPNVHSHSSSMGTAESLELPTSKFQYGSTMLPGIPQQPLFDYSHLPQQQPQSQVHRPWDTTMATGPLHGSHAQQASLGMPGRPGGGLGGPSASGAGGALRAFGTTSDFFTPRGLDPSSGMLGGAPGVMPGVPGAGPSTMAGATSSSLLHPLPQQMAQVDPYCYPALQQPLPPPVRMPKKGKNHKKADGKQPTFLTKLYDLLDRQEYHHIIRWDDTGEMIIIERPDELAEKILPMVYRQSRFASFSRQLNIYGWMRKVSLRHVESGIHDPDASTWSHPFLRRSSTKEDILGFKRRVPPRPSQAQKNAQRIAAEMNSSDSDSFVGPPSAVDPYAGLLGGLDENKPVFQFGHGPENIKLPKYIPTRAPFETITRTNYGPEPTPATQGPPLPEAYPLAFAIDRKDSSSSRRYSMPTNLSRSGIPEGRPILKDLKDISMTNSFAPSSAPATAGTFSMHSVSSFGPGSRAGSDASVGSVASFASTTFSPNASMANLGIEDQYAIEEDDFLRGSAEQPQYRVDDVSSWSRRGMGLLGQGMRPSPPMQFYGFVDPKMTNNVGPVNFGAGSVPGMLPTGMQMPGGMPGTVNPSTGNMMGASVPMSINVGVMGEKGQPATPPSTVSPGVYQKGFNLPWSSPKEGVVTGGVGVAGVGRSSPALSSKKERRQSLTSPYSTNSPPRGHTGVVRGVGGNNKRDSLPNIPIGSVPGLGQSPAQQHVQPGAGQAGQQPASGHTGAGHSAGHSAAHSGTTTDDEGLPSASLDRPPLFQGQLEMDAASVHTKEISATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYQ1</accession>
    <name>K1VYQ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYQ1"/>
    <dbReference type="STRING" id="1220162.K1VYQ1"/>
    <dbReference type="eggNOG" id="ENOG502QTFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035354_4_1_1"/>
    <dbReference type="InParanoid" id="K1VYQ1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007402">
        <property type="entry name" value="DUF455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782">
        <property type="entry name" value="SI:CH73-314G15.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04305">
        <property type="entry name" value="DUF455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="80"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="503" mass="56366" checksum="34577129DE2F316F" modified="2012-11-28" version="1">MTAVRARVRACRLADTYSHTRFHLALRTKTQPSTYHRLLLFRVNNVYDSNKSESDTPDAKEATEKEAPCPTLATVQNPGSDKPELYCMEETCPHLGAPLSHAEIEIDDIEDTRAVGELEDEFHRADLPVCPWHQYDFATGLKTCTYNVEVIGKGDDAEVWVDAPHNDGGHEWEVVEFRGVSEEFADPPIPSLKDLNLGDGPIPSTVPGQPQLELPSELPTSLLGFAHLVLATADPDLKCILTKEGVQRMRAGKLKSIRPTKGEIKRIRETVGLLDEPPRFATIVPLNKRGKLGRGGTEKSRIKMLHALANIEQYAIDLAWDIIARFAEFEIEGERLPVEYFLDWAKVAEDEAKHFSLLNKRLREMGSYFGSQTVHAGLWKSAMETADSLLSRIAIIHLVAEARGVDMNPLTLAKLRLAKDEESAAVLEVIHADEITHVTTGHRWFSWICAKQGLNPVQQFRDEVSSHFHGDLKGPFNVEDRAKAVSDIARLMGERQDERKHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZN6</accession>
    <name>K1VZN6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000159">
        <property type="protein sequence ID" value="EKD05022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZN6"/>
    <dbReference type="eggNOG" id="ENOG502QURF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485872_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZN6"/>
    <dbReference type="OrthoDB" id="2594386at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="245"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="561" mass="64714" checksum="F3C08473A77E12C8" modified="2012-11-28" version="1">MSLDFLERPRLTYLNPATPSAELSDQDLIDYQRLLHLEITPIVSWLESEPEDRDYTLLGDFIGIAEDVLEAWHQLFGAIPRGKFSQVYILLENFYKTLASRQGFLDDQPEPSSVSLGRLPSQPGLQGAPRLDIDLVQLCSLLSIRDLTYEEIGHLAGCSGKTVQRRAKEMGVNRRNFSEITQEELDRAVIAAYLRGSGDQGYRAIHTYLELEGIKVTRDQVQATCRRLNPNGTWDRWIRARLRRVYRVPWINSLWHIDGHHKLNPWKIVIHGGVDGFSRRVVFLRASNNNLAMTVESCFMEATRLHGWPSRVRVDYGGENLGVKKRLEEVRGTVDSKGRWRGTFIQGPSTRNQRIERLWVDLQKTCTSRHRSIFIYLENIGYLSPDNDIDLWALHYVYLPVVNEALKCFVSYWDKHRIRTAGNQSPAKMWAMNEAKAKKLKIRTIQYLEGVHGQEDEGIMDLPDDRTQQYFEDYGVDDYGRRPMAQLPSQDPQVEVPSPDEGLPTVHREFLYDPAFLRALQDSVGPVWPVDDACAMPQYLKCREMVYARLGFQPPMPHWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W650</accession>
    <name>K1W650_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W650"/>
    <dbReference type="HOGENOM" id="CLU_065431_0_0_1"/>
    <dbReference type="InParanoid" id="K1W650"/>
    <dbReference type="OrthoDB" id="10676419at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="340" mass="38181" checksum="123F4615E8EB9373" modified="2012-11-28" version="1">MPLPLPALVDGQASSPPAQGVTIDHRFFPHIIDTIVSYMPYLSLVVAAMVCKSWNEDAKRRLFRLGHVTVMESNNGAYDIEIRSRNTAWPGYSSLLAAVRENHVSRFGNDIRIIDLVPNPARHPFDPVRHPDALEKLQCYQSRIHIPAGVKASHFHHLFAGQTICFLDYSENYRLSVADRICGGSSVTVTLDCYSDPTTPMAPLHEEPWYLIFCTATEHLEDFTVILNNRVGNTAPPPVNTSPRVVTDHLEGIEDWYLERGDPTLGAVYDVLRLTLRVPDIVQIRVVGVEQFRSDEELTKYSVAVQDELDHEADIHRDSPQHGKLQATTSNSTLMRSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W719</accession>
    <name>K1W719_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W719"/>
    <dbReference type="STRING" id="1220162.K1W719"/>
    <dbReference type="eggNOG" id="ENOG502SDD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754766_0_0_1"/>
    <dbReference type="InParanoid" id="K1W719"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="367" mass="39454" checksum="F55FA095850F3495" modified="2012-11-28" version="1">MSWLPPLPTESTLPTAPGAAAIMADTTTEPQSVVDRYRQPIAYNASQLRETHTWTDPPKAVVDKLPQPTSSFQSLLHTYAATEKEPSVALRQTDGRRQAADMFRLAIGNPEVFSPVDTMAVPVPPPHVSPIVPSHHESLPPRLLPVNPNKDGIITSLIHQIRTPYLRRPLLERLTSLRPPQPQSNDQGPILYGEAVRGADDASLAKARGKAIEDETESWFHATWDSGPKGAERARGRLPTGRKVVKSVEGAVAPRTAGDVKPLRVKLSQQQPQTPAAEAASPAPTSSLGIKLRLGGPKTPEPGTEDRGNAGSMPAWSSDSRGRLGSESAPVKRSGSATSMRSKSRSMSRSASPVKRVSLSPVKQEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8A7</accession>
    <name>K1W8A7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8A7"/>
    <dbReference type="FunCoup" id="K1W8A7">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8A7"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8A7"/>
    <dbReference type="OMA" id="TWESMER"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="326" mass="35996" checksum="4E07D10D726C71B0" modified="2012-11-28" version="1">MANDVPTSFKLNTGASIPAVGLGTWKSEPGKVAAAVSHALKNGYRSLDCALVYGNENEVGQGIKDSGVPRKDIFLTSKLWCTYHDRVEECLEKTLAALQTDYLDLYLVHWPVRTVENGTNEMFPVKEDGSRNIDRQWDQADTWRAMEKVLASGKVKAIGVSNFSKLYLERLSKTWKTVPAVNQVELHPYNPQHGLKAYCDEKGIVLEAYSPLGSNDSPLHEDPVVQAVAKKHDVSPATVLISYQVNRGVVVLPKSVTPSRIDANAKVIKLDADDMKQLDGLAADGKQRRFVSPPWGTDFGYDDWFGPDNKDAPEGTVFESRGETFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W953</accession>
    <name>K1W953_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000107">
        <property type="protein sequence ID" value="EKD05353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W953"/>
    <dbReference type="HOGENOM" id="CLU_1157091_0_0_1"/>
    <dbReference type="InParanoid" id="K1W953"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="25382" checksum="3275B8F06C249EA9" modified="2012-11-28" version="1">MSEPGLPVGQPRKLRKSRSASDVGSGSLSKRFGKFVSKVLDKAPTSPGKTDLTPASASSTSPTQSLALESLRASVGSSGSQRASLRIRTGLPFDTENPPLETLPEVESTPAKSRLPSKPPRISIPPTGSDDLGAVETLFQQYSSRETSSAPARSQSLGQLQLHVNPEFTTDPVYSTFPRSPRPDTIPPVSSDNDPSPPKSTLSESSQETERADESSKPLPTLSSSIGENRSLISSSLPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9E3</accession>
    <name>K1W9E3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9E3"/>
    <dbReference type="STRING" id="1220162.K1W9E3"/>
    <dbReference type="HOGENOM" id="CLU_041051_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9E3"/>
    <dbReference type="OrthoDB" id="10685437at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="410" mass="47712" checksum="9AFDAA73A7713C67" modified="2012-11-28" version="1">MTVTFSYANFPNLWDMILAAAEHETQLALRLVCKSLRFKVDCLQARHLVISSEGAKQLLITGPNHHIAHFRDIYHLDKEPRFWSFHATRARTRHTRILDIQGYCPPGNDPDLFTYMQFPHLNVLRMTPSVDDDPDNFTPYIPGHFEAQTLVLFSNSEGCAAMDDHWWFDLYAPSDDDEELPLVPPVNRSRIPQSVTKMVLNLRGQNMELHDMYPFVTRLPAHVKDVVISAPAYRSLLNTAGVRNEVSPHLTKLRLVDVVLLPIKTKFTLVDFNWLGPSFEKEFLDELRYRYRSFFFKDVDYTVDDDMTRVMQRKTRDECIKRSTTVEVTRKPLISLQEQIDKLLSRIEFLSKEAYIERVGAETAALDLLEHLDLENSDCVEGEYDWRSKRACYGTQSQPDYWHQMRTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9I9</accession>
    <name>K1W9I9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9I9"/>
    <dbReference type="HOGENOM" id="CLU_1653385_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9I9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="160" mass="17179" checksum="1776E6EABE903DE2" modified="2012-11-28" version="1">MASSIIAGQHFQHLVFGRKQPKTPLANASWVAWGMKLGPLVDASQLVTADSAWGETQPVLGHDALSKVEMAVVEIADLILSNVLGRLRSCNSHNIRIVDIVVAKVMAVRMQTRLRAPRELQVEDTGAPIGVSGFWTASQLTSSQGRGGGTEVTFYPTTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC91</accession>
    <name>K1WC91_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC91"/>
    <dbReference type="STRING" id="1220162.K1WC91"/>
    <dbReference type="eggNOG" id="ENOG502QYUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029217_0_0_1"/>
    <dbReference type="InParanoid" id="K1WC91"/>
    <dbReference type="OMA" id="DADPMEN"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="74546" checksum="95AB4DAEBD7EB261" modified="2012-11-28" version="1">MQDPLTVLGEDIFVEVLSNLGVNDLCSSERVTKSWLACARAHSSGLWRHASLVDGVEPFDLQTCNNLAKNGIWGIDEYDRRPIAFNVYRLLETPATAMRELPEWDWSDVAHDADPMENKGNVDGKRRTRVNWRYVCEAHRSLQNAWSLARCRLRWVTPPTNTVWRIKSILEQDILLCTSRQTHRNGLITVDQHTSRPIFCIEGLDGYAHLEAGRGYVVFNRPGIIDPALGFNVDDDNALEVWRTGEARARDSLPKVGQSPLSATAVSFTHPKVFCPNRPDGPLPRGHLEHYQTLQPPSRCLAFRLHVDKADTPDAKAVVAACGSNAIYIWHLEEDKPMQRIERDWANIGRPNMHVYSRRTNKHVLAFPPTRSAARDTACFAYSLSLADDFKAVPDDERKRAQTSTLTSGVPAPIGRAIVPGYAEGESGFDEAVARGVAMHGLRVKIDKPEDIEYSFSACHYTSTDLVCTTKTGAIFIVRHYRDVFRAAAELPDGQRAAFVKKHTVLIGLGTVIRQLTTYRDHIVLCTVRCSCTDQADCQSFNVILINGKKIPEIPEEDALYSRILQPLKEDLKELEKGMPMRARGNEEPSLDAQRPMLRAHVLLGNHPQAMKFSSCVQADARSIYLTYWAGGEVEATGGADSGHVSYPPAEAVDGFGMCVKVWTFGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE58</accession>
    <name>K1WE58_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein l30-1 (L32)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000356">
        <property type="protein sequence ID" value="EKC99903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE58"/>
    <dbReference type="FunCoup" id="K1WE58">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WE58"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="InParanoid" id="K1WE58"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="12187" checksum="DD2BBD78CF849C67" modified="2012-11-28" version="1">MAPKKSKSAKSSENINSRLQLVVKSGKYTLGYKQALKQLRNGKSKLILISKNCPPLRKSELEYYAMLSKTSVHHYEGSNVDLGTAAGRLFRVGVMSIQDAGDSDLLQVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE99</accession>
    <name>K1WE99_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE99"/>
    <dbReference type="HOGENOM" id="CLU_370139_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE99"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="752" mass="79336" checksum="9AFAA1D32719A0A6" modified="2012-11-28" version="1">MKRPCRPNRAPPLPGLGCLASLRAFSSLPGCVLSAEADVMHGPGDSGFKNNYDKRRMESSAARSGAATTTATATATATATATATATATATATATATATATATATATATATASETTGWTPRGRLPLELVQFVVDELSAQQARGTLASLAATSGPMHALVLPVLYRRLVLTRANAERVLGLPRCPPGASTADAEDAEDAEDEEAYDPRCPRWHDALASNVGAHLARLEADEVYSQRFALPVDLAPTGAETDDELCRPCSPRSPGSRLNPGFAFTTHLVLAQWPQSHLVRSVCAHHPSILFPNVSHFPISARAVARCPKLHEASGPDDVSAFLTTLARAEDVCVAMPGSEAASTTGRTEWVLGCLMRKDYAPRSVTVHLGRHSPPGEVSGGYVAPAPRVEGVFQLAGAFGWFPRPSGAGGASGASGASGAGASRTSKASKASKGSSSPNPTLSAPELHSYLTATPTQETRVTETGGEEGDEEATARVTLLYPASTPYARDDIHSWVYATSPSPRRTIALSLRTAMQSANEQSFLEDGWNEVDAWANDVGSWAFSSSDSDPQLLATLERAQAYASALTRRAARLRKSLDEPPDAGSVEEAESALSAAHEALKTATAALDATDAKTPRLELSRLREERHAAAVAVGMASRALKAAHAEGERRRSIRQHDAGLRYVLTELHAAEDAAGRARDAFEKDRREKRSKRLEGIDVPKGRISFRATGCAVCGSETAGRRTLRQIVDEAWRGPAPEIRSADSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF14</accession>
    <name>K1WF14_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000347">
        <property type="protein sequence ID" value="EKD00134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF14"/>
    <dbReference type="HOGENOM" id="CLU_947286_0_0_1"/>
    <dbReference type="InParanoid" id="K1WF14"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013266076" evidence="2">
        <location>
            <begin position="16"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="294" mass="31619" checksum="AE6688D55400F615" modified="2012-11-28" version="1">MRLLLALYLASPALGAAFTSLQLSGSDGPWCVQTKGDSTEIGTPLEYGKCGPAPTQRWSYVENQLRLSGEVDRCIGLKQGAEAPEAVLASCIPTDDPTVETSWTWDTTKRSQICTYHEKTTTPQQTWCLSAIGGQEPPRLFLSWRQRAGRFEPQRTPGGPVTDEEGKCGAASGDEANAVTSGAVMVCAMPVPNGMQGRNARAVSRSPAQRMAVPGRYLTYTDRLGPTDPEPPTRSITTSTYHENMFDPKRPQIFGTVPPVVAGEPKHSPAAPSITRPAPTTSWLSMMLSGQPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGJ7</accession>
    <name>K1WGJ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGJ7"/>
    <dbReference type="STRING" id="1220162.K1WGJ7"/>
    <dbReference type="eggNOG" id="ENOG502QUGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024117_6_0_1"/>
    <dbReference type="InParanoid" id="K1WGJ7"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="387" mass="42072" checksum="9C082ECBE9136B2E" modified="2012-11-28" version="1">MSIRIKTPSNIKVTSAAVEEEMVSPGGTNNNVTTYDLSVLGPRGGDPQLTVKYEANGQSGVVNVPLAPMPGDRNRGWQQLPGITGVLIYQICTNDENSNTLVFLNEASPTDYMKDLDDNLGLNEIALAGTHESCALHGMPDVRTAGAAQGRPYHGMRPEYGTLKEWTDAFYAFLKDHPTETLVFSLKQEQENDPEFANAIYNCLMQYDNGERWCWSEGVPRLGDVRGKGVLFTRYGSQYPKGQGIHPTSWPNDNPDGFTADLLNGAGKIKIHDWYGLDSPSQIGEKANKIFTLLDTTTGAVPKDELTLVYTNGSKFPGAPPQWIAKGVGAPTFGLGIGGMNPRLANYILNKIKDGQRVKAGIMVDYYQYTGSGENGLPALINASNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGU1</accession>
    <name>K1WGU1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">A1Q2_05066</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000337">
        <property type="protein sequence ID" value="EKD00639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGU1"/>
    <dbReference type="FunCoup" id="K1WGU1">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WGU1"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_2_0_1"/>
    <dbReference type="InParanoid" id="K1WGU1"/>
    <dbReference type="OMA" id="QYQRHGY"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="21">
        <location>
            <begin position="256"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="99"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EKD00639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="539" mass="60032" checksum="F3DC0ED20E6F2F5F" modified="2012-11-28" version="1">MAGTPSSKAGRAGSDPPPPKVAAPGTYTLSDVVPGVKIFVAKPLGNGQEEHRKAEILSTRPKPVSAFAPKPGPNDPKPDPRDDVEYYVHYVEFNKRLDEWVGGSRLLTDKELEWPQPKEESNKKKTGKATPKASGAASPSRPSKGGAPKSLLKKAATKAASQVGKVPSKGKASKSKAGKGSGATTGDETDDTDDADGEDDTDAEGDVSMSSADGDNEVEDMKPSDPRAGPAVFSKKDEIEKLRTSGSMTQSHSEISRVKNLNKLQIGKSEVESWYFSPYPAEYAYLPKLYICEFCLLYYPSLTQLTRHRTKCTLQHPPGNEIYRKDNISFFEIDGRRQRTWCRNLCLLSKCFLDHKTLYYDVDPFMYYCMTVKDEYGDHLIGYFSKEKESAEGYNVACILTLPQHQRKGYGKVLIEFSYELSKVEGKLGSPEKPLSDLGLLSYRAYWQEKIVDLLTESEDEISLDEIAQRTSITHGDIMHTCQALQMIKYYKGQHIIHLTDAVLEQHQKTKAKTRNAIDPTCLKWKPPVFTRSQLSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIH9</accession>
    <name>K1WIH9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIH9"/>
    <dbReference type="HOGENOM" id="CLU_027450_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIH9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="456" mass="49121" checksum="78E9EB3DD51F00B1" modified="2012-11-28" version="1">MGDTSKSGVTPLVPPPDLSSTCTGSPPTCTGDCTCNNPASATSMPVAPPEQMAAGHHPWQAVFIALREVELRAPPKRPKSHDRTAKNTTKGKTRDRGAAGKEWGWDELHGTTFKRLDPASWQRKRQRLWDILPHLPGCPTGALPTTQLDDGTSQTTASGIDRAQVDAVQSAMSRSGPIEVYSENDAVSKWLTSYNKTYEVILQQLARHILGEDANVATHYDVTGESVGIEGATCRPDLFSEVKLELPRENGASQEGDSVDMDVDDDGDSSGAENGDSEWDESDGEENRDEDSSHDVVESSGTTISSGKPSHSNGSSSDCTTQSSCKPESSRGKAAGLPRRCHLTMTEAKAVEVLPDSIFDKLDEDYIPNDNEPHIQAIVYEKETIDKAVKDVRACTRAARRGRQPNLAKTTATSTSSRTTKKTKQKAIKFIRLDNETRSSARIAEKAAAAATATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKX7</accession>
    <name>K1WKX7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKX7"/>
    <dbReference type="STRING" id="1220162.K1WKX7"/>
    <dbReference type="eggNOG" id="ENOG502SFEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642805_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKX7"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="427" mass="45143" checksum="9E2ABCEB39791E9F" modified="2012-11-28" version="1">MAQPYPSAPYAVPLSNPNQQPPRNMYRLNTAQANAGAGYAYSYNTPQSGHFQHQDMQFGLVTPPTTTPAQFGSPLIANGNYSPMPGSAPHTPWGMNALSLSPLPSDGGFSYAPSPMMPSDCGGTEYLATPLSAHSQPGMEMGYGYVGTPGLYRRDQFGMDIGLGVKPVIIGADGQPAPEIKKRSRTAQACERCRIRKARCFGGNPCNRCQKRGFVCEFSQQVRQRGPNNKPASQLIAAAIARGEASPRVVSASAAAAGTAMPASATAATGPKPLLTTDPVKVVRRHSMPDNGPIASVPPPPSKTYSTNDVQTLSVQTNVVDANGTVSMPNSAVPSLPTPTAEYLAVPGQYSRRDAELFSDPQRSPAYSYTPESADTNGGEYPYTPISPGAATFSPTLNMQPSSGPVYAQHLVSEEPQQTQQWYSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WL61</accession>
    <name>K1WL61_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WL61"/>
    <dbReference type="HOGENOM" id="CLU_1220442_0_0_1"/>
    <dbReference type="InParanoid" id="K1WL61"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="227" mass="25051" checksum="3859FF622169E6F9" modified="2012-11-28" version="1">MPTAAAEIEVDAQLYQTFAAQLGLETKTNLLLREWYRHEVGCEPSTPMPYTEGVTSADTCPSVEASDDLKSKLYDKVQSLWHLQVERNRLDAEGFVHRFGYEPRTPLPYTEAGVGENVEAKDAVALLTGVHTALASSWFLQVEKNRLLREAFVVQFAADPASPMPYTDNGTVDENAPTTSEEDAVAALHDAIGQRLGLLVRLHDEWGALFSETFAMQNGQQLPPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMG9</accession>
    <name>K1WMG9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMG9"/>
    <dbReference type="STRING" id="1220162.K1WMG9"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="InParanoid" id="K1WMG9"/>
    <dbReference type="OMA" id="CALYACI"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="94"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="573" mass="62457" checksum="8A673BFAEA06698C" modified="2012-11-28" version="1">MAAISEKEYVKTDGLPADTTVQPAAGQAETYRRESSPPTSLKGKAAGNADTESLNSDITLAAQEEGIDPAFYAKVQVLNRALSEIGMGRYQWELFFSGGFGWFADNIWLQAVAILMPWIGYEWIDPVHVKFATLALYAGLIVGASFWGASCDLIGRKLAWNCTLFIGGMWGVVAGAAPNFVALCCFIAFMGFGVGGNLPVDGTMYLEFLPGSHQWVLTLLSLWWAVGQVVASLISWGFIARYSSDCRDYTYDANKNIIGYCSRESNMGWRYAYFTLGAMMLFLWGLRFFVLPVYESPKYLCSKGQDEKAVEVVHKVAKRNGKVVHLTVEDLDRAAAPYLTPEEKAKGELHKGYTNWQLLKMSVSQGTQMKTLFKTKRLAFSTTLIVLIYGIIGLAYPLFNQSLGVFLRQKQAEIAGAAPSVDDSFKSYTYQAACGIPGSMLAAFLVTVSRFGRKLAMAAFTLCSGIFLFGLTAAKNNPTVDALTSIAAFFQNAMYGVMFGYAPELFPTPVRGTGDALCAAAMRVFGLMAPIIAIYSDANKSPNGPVYASAALYLFSGLIMLLLPVETQGRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPH4</accession>
    <name>K1WPH4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPH4"/>
    <dbReference type="eggNOG" id="ENOG502RB8T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2497843_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPH4"/>
    <dbReference type="OrthoDB" id="2573188at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="90" mass="10179" checksum="8FE32C56509E2997" modified="2012-11-28" version="1">MLLTNIRKLAIAGAVIVVPLSFYGGLAIKEHFLSKEMEVTPEADHKVKERANRARIVQLEEQRKDLLKEGDDIDKKIAQLKAKMEGRNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPS1</accession>
    <name>K1WPS1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPS1"/>
    <dbReference type="HOGENOM" id="CLU_861033_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPS1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="303" mass="33689" checksum="2952A789CFD965AA" modified="2012-11-28" version="1">MVASIDYAAFPHIFMQVLRHCDLATQKTLRLLSSSAKADIDREHCHSLSIFVKGRKLSLLSLLVGTDRVIIIPPLLTLWDGHISAQSPQDERVVFALNNARSLLTRDNELVRLYRVETVESSDDTGGTEPLVSNLLNMHLRPDCTVSLFHDPVFAEPNCTVSLLHDPASADRNSYSERRIQLPPVAAVNVQASRSSLPCPCEPTQTTHVMHSARQLRLTAAGQNASLCGFILNMVTPTVEDLTLVVDHPDNAASFFEATKHKPRNPNLKVTVRCRPVVPQPIMVKCSEEWTGMFHCVVHVQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPU3</accession>
    <name>K1WPU3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPU3"/>
    <dbReference type="HOGENOM" id="CLU_1046571_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPU3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="29838" checksum="2882D7E2AD498290" modified="2012-11-28" version="1">MAIGSTIPNFFRRFGRSRKAPPTPPPPPPPPEPVTIADRLLKLFIKHGETIEEEQRQRRAEALLQLRQQRTHSDALFASLDNLIAKVGDGVSDPDLAAAIYDFRETAEVLFTAAEEEVHEAHHQISQAKGTGDAVIMMLVAEKTGVSSEELIKCLGDAVKADDSYGACQRYMYLSRELMKERDSHREDSRTWAQQKRLLKTEMRRYRAEATVLSEMIDGDMSHVVAAVLDVKRLQEQAETVDSAELRCALTALVDSAARVKEQRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQ55</accession>
    <name>K1WQ55_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQ55"/>
    <dbReference type="HOGENOM" id="CLU_1185761_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQ55"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="203" mass="21719" checksum="B0382D2069A02430" modified="2012-11-28" version="1">MNTSSKCPKTTTTDPAVDAAKERLRHVISSGAGSKHHLQVALRLLNSDEGRQYSDKCDRCQAEGVLCWAKEDASGELEGRHELTCSAAPQPPKSKNQRDASSTAPEQRVALTAAQLELLRQVVRNSEGMLDMLAPTVSDTLLPRMGFRMAQNTVEGAKGGIDELAKQMNEGGGGRVEVDGEAGFKAGEVDDEADEADVEGQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQ62</accession>
    <name>K1WQ62_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_02608</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQ62"/>
    <dbReference type="FunCoup" id="K1WQ62">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQ62"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQ62"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="237"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD03159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="329" mass="35869" checksum="A12A478A7A698A41" modified="2012-11-28" version="1">MAPTKQDINKTSSESSDFPILHVRSASTLLRLTTGLGPNPYVRMEMGQECKICNRPFTVFRWNPGQGGRFKKTEVCTTCSKIKGVCQTCLLDLEYGLPVQVRDAALQRKNEAPTGDINKQYYIQQMERQMEESGDGMAYDSQAANAQAREMLKNLARNDPHYKRNRPHVCSFFAKGECKRGDACPFRHEAAESSASGNSQQSIKDRYYGTNDAGAQKILRAAGEAKGLKTPEDKSITTLLFLGLPSVGEDAVRTALHTAVPSVKPTDVRSISLVTANNVAFVNFADRASAEKAAGALGLQDGIEIDGKKCKVVWGRARAGKSKAAKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTM9</accession>
    <name>K1WTM9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTM9"/>
    <dbReference type="eggNOG" id="ENOG502SF37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819373_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTM9"/>
    <dbReference type="OMA" id="CEISAWG"/>
    <dbReference type="OrthoDB" id="2576477at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="339" mass="37589" checksum="0568C485EB918D8A" modified="2012-11-28" version="1">MTRRQPQSSSGGSEASYVVDVEAARTEGSGFTRSQPHRDVSHPLGSSPPVPSPISPQVDPLLSEAGATPSVDHDQEFIFVNGQLFPKPATPTDAPPPYAPYPAGRARAQTFTAGSPLVALPPLPQYRRESAPGGTETTPLLASDPLERARYRSPFEYIIKGDERGYWSTLCDGAAWKSLFHTLVINFPFNLALWPLLLTGTLVGTALLVTLPLGAVFWFATLILARAAAAVETRLQVFFQGVEVRTVQPIFYRQRVREDGELVWDRRFLSCSWAMFTDQYSYSALVYLLLIKPVIVLVSFVALLVLFILSFVFFPFLPIFLRFARAFGRWQAHIALDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU98</accession>
    <name>K1WU98_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU98"/>
    <dbReference type="FunCoup" id="K1WU98">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WU98"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517947_0_0_1"/>
    <dbReference type="InParanoid" id="K1WU98"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853080" description="AB hydrolase-1 domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="271"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="526" mass="57234" checksum="B7DA2BEDBDF6ACEF" modified="2012-11-28" version="1">MRSNLLYFLLSTILLVLALAAPAEYDHGLEARGELDIDNRGAVSLNRRDESAEDATDAADVADDESVTDAEAAKRDPTGRCPAGKVPRTKGTSPTTLFQSGDLGLHSVLDSLQLGQEPPPHADNVWASSVNLSGRGLVESGGPVEVLFASAVRRDRGDFLSGTRKADRRHVGGPKNGRGDYRFPTLSQLSTILPTKARTPSTLRGAVPTMIRTLRPLARLPSSVGAGPSRPIAFARSFQTGYQKPSSGPVDLAYDVIEPKHPSGLHGDQCLVICHGLFGSKQNWRSLSKRFAQELGMPVYCLDLRNHGASPHVEPHTSEAMAEDIALFLQKQGIKSGLNLMGHSMGGKAVMTFALNPELNGPLRSLISVDMAPYKGKLSKEFTQYADSMLEIERAGVATRGEADKILQKVEPDIGTRQFLLTNTKNEDGKIAFRIPLELLKKYLDAIGDFPYTPGQSDSPHWDGPALFLQGTKARYINERNIPVAKQFFPNMQLVPMDTGHWVHSEKPNETVQLVESFIKTGKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WV92</accession>
    <name>K1WV92_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WV92"/>
    <dbReference type="STRING" id="1220162.K1WV92"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324910_0_0_1"/>
    <dbReference type="InParanoid" id="K1WV92"/>
    <dbReference type="OMA" id="WPTPQVA"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="608"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="698"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="762"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="805" mass="84045" checksum="F85D58F6DC7E7F4A" modified="2012-11-28" version="1">MSPSTQSKSTSVFHALGSYADRTKDATGKTITPNGSALHSPAAVSSSLSSPTPATTPMPSTSTSKAAPAAPAAAPVDDDDESWETVRSSRQKPRVERNTEEKRGSNSRNWREREEKPKASTEEKEESRSRPSKKESRPSSTTSSAQASASTSRAASVAPSKPAWGGSAPGQSAVAPPTAASTSNATPSAANSVNGAARPAAAKNGEASTSSESTIKGNASDEGSWRARPKAEEKPAAPVPKQAAAPPAVNAWDLRKKQAPTPNHGTRPSSSTPLQFGSVAASGSTPTENKSASESASTETTKPKKKKKESAPPPVSDVNMWPDVNAAKSDEKKSKQDKKTGNAAEAAAPVEEPTSGNVAGKKAKWTPIPAAELQEAADKAAESSRQRKAKRGPKDDSESKGQRGKKGNSDKKGGSRAQRSGSHSEPHNARMNGNAFRFNGSETGDAPNGAEFANGAGSTPMSRTGSALDKRSPGGTQLPLSPEQAGRDEHSRPTGGNASQQGYGANATLPRAPRGRDREGRGYGGRGRGGYRSVSQATGGGRYDLSPLQGNAELAHAYTRGYGMGYSYYPMPPAGFVMPVDPSHATYPGMPMYARGTLPPPPLPVTQVPNLDPLRYWVLGQVEYYFSMQNLAMDFFLRQQMDLEGWIDISMIASFNRIKSLTPDVAIVREVMEMSSLLEVKGDKVRLGGGEAKRWVLPDAKPSSLEGSGSTLTSPKKSSEATEISHGLPPSVDTGVSALGIENMIPVSPPTKFDVENALMKSSGSANVSSTASVLASDDAKTMTPATSIAGDTNASDNDDASKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVC6</accession>
    <name>K1WVC6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60s ribosomal protein l33-b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVC6"/>
    <dbReference type="FunCoup" id="K1WVC6">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WVC6"/>
    <dbReference type="eggNOG" id="KOG0887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_2_0_1"/>
    <dbReference type="InParanoid" id="K1WVC6"/>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="106" mass="11871" checksum="9D223D432F2ADBC1" modified="2012-11-28" version="1">MGATRLYQKGRILGHKRGKRNSRPNQSLVQIDGVDSKEAARSYLGKRIAYVYKAKREINGSRVRVIWGRVTRPHGNSGVVKSKFTSNLPAHIFGASCRVMLYPSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WW87</accession>
    <name>K1WW87_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Map kinase kinase kinase mkh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000150">
        <property type="protein sequence ID" value="EKD05034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WW87"/>
    <dbReference type="STRING" id="1220162.K1WW87"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="K1WW87"/>
    <dbReference type="OMA" id="MDGEDWI"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="285" mass="31938" checksum="411382490B75BE4F" modified="2012-11-28" version="1">MVEALRKEQGLLQNLYHPNVVAYLGFEEGTKYLSIFLEYVPGGTIGSIYRTPDHGRFEENLIKFFTGQILQGLEYLHSNNVQHRDLKSDNILVDANGVCKISDFGISKRTSENAYESNLNTSMQGSVFWMAPEVMMKDQSRDASRGSGRSSSGSGREDNTYSAKADIWSLGCVVVEMWTGQRPWGTMQMLPVMYASTLGHDTPSIPPEILETMSPTAVQFLYSKCLCWESKGRPTAAELLSDPFVTERDSTWTWHNSRIGRSVAQKGLETYRNASYSTNGRAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0B2</accession>
    <name>K1V0B2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COP9 signalosome complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0B2"/>
    <dbReference type="FunCoup" id="K1V0B2">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V0B2"/>
    <dbReference type="eggNOG" id="KOG1464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028981_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0B2"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="209"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="35928" checksum="336994B68F2A3FE5" modified="2012-11-28" version="1">MSDDGDDFMMDTALKEDDPQGALKAFRSIVDEQGEKGECLLQYASRSPDVPLDTLEEFYEVTRVACEEAKNECKLKLAKLWLDRKEYARLTPVLEALHATCEPGSTSASEDQTKGSLRTEAWDKASTDLFESFRQYDECGSSQRIQVLKYLVLAYMLMGSEINPFDSQETQPNDPQIVAMTSLVSAYQAQEKLTTVNASTITADPFIRYFIEDLLRSLRKQYIVDIVKPYTRMKIDFLAQEVENLVVSLILDGRIPGKIDQIQGIIVLNRFRAEQKDRYVQVSQLSKELATLSNRVVRDKVARDARSAWMGGLESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0V2</accession>
    <name>K1V0V2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spliceosome-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0V2"/>
    <dbReference type="STRING" id="1220162.K1V0V2"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006308_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0V2"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="407"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1139" mass="129119" checksum="B93E9510EE4B9909" modified="2012-11-28" version="1">MPRSTSRSPSVDSRSPSPETSKRKRSPSASPRARSPSPPARRRRDRSPDEEPPRRSEVKDAGENGNGTVAAPSADARAEFARLLGSRSGGAYIPPARLRAMQEQASKDKTSPEYQRMSWDALRKSINGMINKVNITNIKHVVPELFGENLIRGKGLFARSVMRAQAASLPFTPIFAALVAIVNTKLPQVGELVLTRLIAQFRRAYKRNDKNVCNATSTFIAHLVNQYVAHEIVALQILLLCLERPTDDSVEVAVSFMREVGLFLSENSPRANTMVFERFRAVLHEGAISKRCQYMIEVLFQVRKDKYKDNPMIPEGLDLVEEEEQITHRISLDDELKVQEGLNLFKVDPNFLENEERYNEIKREILGDSDDEDSGSGSDYDSDSESEDDVAPEKEGITDMTETNLINLRRTIYLTIMNSLNFEEAVHKLLKVNIPEGREVELVNMIIECCSQERTYKAFFGSIGERFAKLNRIWTDLFQDAFQRYYDTIHRYETNKLRNIARFFGHMLASDAISWAVLHVVHMNEEETTSSSRIFVKIAFTEVKEELGLKKLVERLKFPDLQPAFAGMFPTDNPRNTRFSINYFTQIGLGAVTEDMREWLQNAPKLLAEQRAAAQDSSDSDSSSVLSSSESDLSSSDYSSDDSRYRRRRRYSSDSRSPPRRRRYSSDDSRSPSPRRRRYSSDDSRSPSPRRRRYSSDDSRSPPPRRRYSDASDRSPPRRRRYSDSLTPSPDRRRKDSTPPRRRDDSPPRRRDSVTPPRRRRDSPSPRRRDDSPPPRRRNDSPPPRRRDDSPPHRRRYDDDTPPRRRSPWLADHAGAPQVGCIRFMCAFPLSALPAALSSLHPLSAITTSMSGVREASHAGSWYTNNSSRLTAELSGYLDKVHPLNNPPFSPPVKEAKAIIAPHAGFSYSGPAAAWAYAAVPVDKIKRVVLLGPSHHVYLSGIALSKFASYGTPIGDIPLDLEAIADLRKSRLFSDMKSSVDEDEHSLEMHLPYIRQVFGKRDIKLVPLLVGHPSEDKRKAISAALSKYWNDDETFFIISSDFCHWGSRFSCTPYYPHAPDPPNPVPPVPANSTPQNTPTPELVKRYAGQSSGDVPIWKSIQYMDHEGMDLLRSPARDGAVEEWESYLARTKASNKHPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1R0</accession>
    <name>K1V1R0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1R0"/>
    <dbReference type="STRING" id="1220162.K1V1R0"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_2_1_1"/>
    <dbReference type="InParanoid" id="K1V1R0"/>
    <dbReference type="OMA" id="WDWLAHI"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="593"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1077" mass="115492" checksum="8C90455ACFDA205B" modified="2012-11-28" version="1">MVAPVFHARSLTELVALRAGTSLPARVQLTNVETQADEPFVHTGAPEFGDTLLTLTYSDVQRAVDRLAAHYASLALQPEVEEGEEPPERVIAVLVSTAVDESLLEIALAKLGLTSLLLSVNNSAEAVAHLCAETGATHLIHGPKYASVAAEAARILNGDREDPGTGSLAPTTLAQPIQNGSKARTTAPRLQLVEDRRFPLWGPGGVRSAKICAFPPRLSPEQESRRTCVILHSSGSTGFPKPVFVTHYGMVANAAVSVPKTGFSALPLYHGFGHFSIRGGAALLTPSFRCLYHGKAFTLLPPHWPITAANIVRCIASSPTPPVQHFAVPYVLKLLAESPAGVQSLASMEAVSFAGAAVPDELGDRLVSAGVPLYSQYGTTETGALLTSRRDYTADKAWNWLRVEGLIASYLDLVPRGSGTYEAVVRDGWPGKVMSNREDGAYCTKDLFVKHPEHDDWVKYVGRLDDTLTLTLGEKTNPVPIELDIECIVFGDGRPQVGALLLPSETGAELSRNRAAYVEAVWPVIAAANARAPSHSRLLPEMVEILAPGTEVPVATKMSILRPACYRKFAPIIDEVYRRFEGGSGAVEKRRIDGENEAETYLLELLGRTLGSRAEGITRETDLFAFGVDSLQATRVRNTAQKELDLGGATLGQNVVYEYPSVSKLAEHILAVASHSVHANGTRSAYDEMEAMASKWAARVVPATPGNRASGNPVILVTGATGSLGAHAVACLLRRPDVRIICLSRAASHADSRDRLAHSFALRRLEPDWSRISSYAGDLTLPDLGLGDALADVRDSITGVLHLAWPVNFAAALGSFEPSVAGTVNLLNLTQGSPLAPKPRFFFASSVGAVQAADAPTIMEDFSDQPADAGATGYARSKWVVERVLAQTRGTVLRIGQLVGDSTHGVWNETEAWPLMFRSAVSTGSLPALEEEVGWLPVDQAGEAVAEAALSPSGDGVLHILNRHTAPFASILAGLRRAGVVFETVPRREWLRRLAESDPDVAANPTRKLLPFYEGRIGGDVEKARPAFDARKAEERCQVMRGLGPIDDGLVSKWAEVWRESGFFPPSSPVQPVQNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1S5</accession>
    <name>K1V1S5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V1S5"/>
    <dbReference type="eggNOG" id="KOG4820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001302_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1S5"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="674"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1792" mass="198000" checksum="4443B7D7E3DB5244" modified="2012-11-28" version="1">MLTDTVPALTYDMPSAVPTGTPALPAGAAGPSFNQPFAQPSHGRHISIDEPPKPKRPPQLRITTDFSSKTLESDPGSSKTSASPEVEPARKPRRVPHHRKSSLGLAQSRGLHETQKMLNLLLDRLEARSAAPDVLDRAVIKARKEAGHITRRRRFGARLGEVAVAAVTAAQKKKINIEDDGDDSDDIDDILILDEDDWDTDATTDLVEQMRDLLVLSERQVLDLFGASQIAAFDKRNAAKDKRKSSRFSSMTASLSKVASNDSHAGPGGEISGPRLLQRLAAILRSLILIDCMYTTYRFRPLKPPYFLQSMCLDIAAVLYSKGDMKTKLHVFESVTDALYGWGHPMRERICEWLEGRLNELLVRLAEERSDGMEEDQPRVVFNDPFSPATSSPPQVTADIPTFAFSVETDDGDRSTEPKGKGWIEHSSPASSTGSRPWNRHLSGVLSTHSTAISSLALQISALIPRLLIAIASIDMNSARLTTLFRVHRLVSLVLNAKPDVGSDLLEIIAQGSSDASQRGFDMLTTYFPLCTGHNTIARRPPLCTYLAQRMKWETGQERELGEDDMESHHYLPWRGSESGDNLCQTCERPCEGFCVRCTLCQDIKHVDCLLLYGDELVEWATTVVGGSSSKPTMPRHENVTVKYSKCVPRLDEKVHDGGPTQNGPEATVRTVGQHTFHLVNLFTLTLCGDCREPLWGTTKQAYVCLGQCQRFFHPACIDKMKDRGSTLCRPGTEAFVNTSDPDYKRDPFTTSVQVVQESFARSASEVCREPSRLAKLSFDETALLYAHLWIQHEIYLNGVRAGSIRFSGEAPTDPAIIPGTTSLLEHYKQHLGQRELQASAALQDYSRTTGEPIRDAKDLLWRPRYLEYCSALLKAPFDPSDHLSGSHQLLTPGQLGSYEPDPPTTAFEALGMTSVRQSMASDLNIRDRLAAAILLERMRGFGLCAVPHCRKIGPKQVQDTQLLVTFPIPLLLDSSPSVELLVLAIEQLLDVVDLTANEQAFNLLCNRAWPSPMCSSYALERLGGAVLSWVMDGDDVLHYVVKNYASKAKRPPGVRVGRGASKGTTAVATYRDDRARMFERYAKPWLEALHALDSSLYASLAYDRSKMTDNKYQVQELSKDSSAASQIAGMALERMVTLADVGASFSIVLDLVVAWLEDLGAVSKQHANSQKGVLGEDLWELAKATSQEGPEGVRRVCQWLRVLSCSGAEVPWETVTDMVELVAGADVASEARLDLISTINSNTTQTDSKAFAQLCNRQLVRLGGALSFRPTDLELQMLRTNLLSILRAYGTSATDISETSLKMPVVEQPTLNTTMRNKQLPTPPTSTPTLIALDPSVLHVVASLLRRKDYPAEILLDFLWLLFMRAPAVENADGFLFQHCATLYEARVFLKLVMVNSVPIEEMVRKELEQVDQASLRERMLTLVLELADDVVTADLECFRSNAVGLVMLFFTEVVQPLNPIPDILSTSSRAAMRRRRSSLLSFSSSERYSLLGQQIINEQQAASIHFGNSDTPQAAAALEDARLIHATTLCLGLNMLAAGVPCEWAMLQEFQRCVAATCAPPWQHPKETVTGLLLPGLKNVLDSTARIMVENESHDDKDRKTITVGSLFVPIVVEFANDLEMEEVLVQRYILDILLVVYYKHNVQPVELQALSTLQTLATFAANRLQSIENRLLAVQILNTAENHMTKDRFSRVLPALFVLVADIIAKESSGGDSALVDASRGFLEASIESYGDAGLFLQVLKQDGQKSKGDNSSEALGKALQIASREQTEDGSWRYTWIEKVVTDLYVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1Y2</accession>
    <name>K1V1Y2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 12">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_07746</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 12"/>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1Y2"/>
    <dbReference type="FunCoup" id="K1V1Y2">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V1Y2"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1Y2"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="14">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="15">
        <location>
            <begin position="213"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="545" mass="58511" checksum="5DB7CCFFDA9D67E9" modified="2012-11-28" version="1">MSSTAELDETEVLVIGGGIAGCAIAYGLSQAGRKVTMIERDLSEPDRIVGELLQPGGVAALEALGMADTLEGLDATPVEGYCVISGERQVEIPYPKIGEEVDAMLDLGEKEGHENGHADGVACRANGNGTNGTTNGESKAAAYWPVSSKSGKKEGRSFHHGRFIQSLRRKVATSSTTILEATVRDLIYCPHSKQVIGVKCTAKGSAEEVKLYAPLTIIADGCFSKFRSAPGAALPTPQLRSYFVGLVLKDTQLPIQNHGTVCLTPAGPVLLYQIGNEARETRMLVDVKPVEGKLPSVADGSLKRHILDDFVPHLPPTLQAGVKHALETDRLRSMPNSFLPPSMQGLSSGMSGAIMLGDAWNMRHPLTGGGMTVAFNDAVLLTRILAPSEALPAGRAGLEKWDVISGRLQDWFWARKDLAGTVNVLSIALYDLFGGADGDLEVLREGCFRYFELGGECVAGPVGLLSGLRPEPFTLFWHFFKVAFYSIAILFKFGKPGAKSKPGAAEWPALVAYSFKVFWTACVVFLPVMLSELKSNTHRQKKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2B1</accession>
    <name>K1V2B1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD/DEAH box helicase involved in nucleotide-excision repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2B1"/>
    <dbReference type="FunCoup" id="K1V2B1">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2B1"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302104_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2B1"/>
    <dbReference type="OMA" id="ANTCAKL"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="632"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="829"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="988" mass="108865" checksum="C16B24A6EBEA8FB0" modified="2012-11-28" version="1">MSQSSQFSQRQRPRRALDYDLDSLIDLSQPTPSKPRSKDPIDLTDSPEPTISSPAPGRRGKGGLYPVMPTAPLSPSTRPNNARARPLSSQPSLSSSSVSSQREVSLYDDFDSGFGSSISKPKKTSAPTPAPARSSAPRMANDYGAYIRPATAFKSAPRKSAFDQPGYRDGWPEWVSAPASKVPSPQSAPEPEEKDKEPEEVEMNGEDFDLNQAKFTAEDFERFHGDPEEQMRNLLAGAVGEGEGEGEEDEEGADTVEGFADGMRLMPHQVRGVKWMRERETGRKYGGILADTVQTLARVVEGRHTPSEKKAYKGGTLKLAWIQLKLTVGGKELEKFDVVITTFQVLASEFKARGQRAAPSDSDDSDDGLRKKLKRKKKVMAALYDVKWLHEAQNIKNHKTQTAKAAVALKAKYRWCLTGTPIQNNVEELFSLFQFLRARPLDNWQVFKARISSEVKNGRTGMAMKRLHIILKAIMLRRTKDATIIVQCEFDNDEREFYDALEKKTQLTFNKFVNAGTAMANYTSVLTMLLRLRQACDHPLLVSRSAVDSDTLGRDGENFNREMSADAVEFDDGEDLADLLSGLTVAGPKKCELCSAPLPGVGGKHCLDCVRITRRAGSEARGLPPSSAKIRMLLKLLREVDSRSKNTEKTIVFSQFTSFLDLIEPYFRAEDDGSLAADKRQNVLQTIRTSAKHRVILISFKAGSTGLNLTCCNNVVLMDLWWNPALEDQAFDRAHRLGQTRAVNIWKLTVEETVEDRILANQKRELAKAVLSGEGAKNLKLTMADIMKTPSTMSWYETLTSAPVLLAIAVGISAILYVLQANPQPREHWVKQQQEAARAAAGGTSGAGSGKQATETKDPKAKLAESISVMSAPAADLAPPKDDPISVAELRQYDGSDPSKPIYVAIKGKVYDVSNKKEMYGPGAGYNVFAGKDASKGLGMSSLDPKDAIADYSTLNETQMKTLDQWDSFFAKFQADDQRYNIVGKVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4H4</accession>
    <name>K1V4H4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4H4"/>
    <dbReference type="FunCoup" id="K1V4H4">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V4H4"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="InParanoid" id="K1V4H4"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="860"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="877"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="896" mass="98994" checksum="76418BD5630BAFFB" modified="2012-11-28" version="1">MSTLLAATSEYKGSVLALPSGRWPCVAAPKQLPEVVVSLSSQILTATPQAAAPPPLLRQAVYATLGEGRGRESVLSSDVASVYATSVAGTSHLEARPDCSLADLRKPPNSDCGFTFLIRFLNMASTECSIVVGIDFGNLSSKIGVARHRGIDIITNEVSNRSTPSLISFTPKQRFIGEAAKTAETSNFKNTVGSLTRMIGRTLDDPDVQSEEKKYINAKLVDVGGQAGTQVQYLGDATDFSYTQLVGAFLGKLRDTASTELKQAVSDVVIAIPGWYTDVQRRAMIDAAKIAGLNPLRLINSNTAVALGYGITKADLPEDPENPRYVVFVDVGHATYSVSVVAFSKGQLVVKGTAHDRNFGGRDIDYALVQYFAKEFQSKYKIDVLSNPKAIFRLAAGCERLKKVLSANTEAPLNVESIMNDVDASSSMKREQLEGLIENLLNRFDGPLEAALTQAGISKEQVHSIELVGGSTRIPAIKDKISNFFGKPLSYTLNQDEAVARGATFACASLSPVFRVREFAVQDIINYPIKVQWQKEPGNPDEETELTVFPEKNAMPSTKILTFYRKAPFELESEYVQEPPLPVGTNPRIGQFSINGVKPTDSGDLACVKVKARVNLNGITNFEQAYGVQEVEKEEVTITGEGDDKKEETRIVKKLERTGDYPTAAQYNTWSDKVVDDWLEAEGKMHADDKLVQETEERKNALEEYVYDMRGKLDDRYKAYVQASEKEQLLSGLQQAEDWLYTDEGEDAPKSAYVKRIDELKKVGDKVVLRWRENDERPRAAAQLREVINNFLSAAQNGEEKYAHISDEDKQKVIEKCANTQHWLEDKLARQMEKPKNVDPIITSAEILKNKDDVQYTCASIMNRPKPKTTETPGTETPKEAPKEEPKQPEEDMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4K5</accession>
    <name>K1V4K5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4K5"/>
    <dbReference type="HOGENOM" id="CLU_602945_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4K5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50967" checksum="110FA0167FD7F4FC" modified="2012-11-28" version="1">MDDLSQAVSDKLNLSKENIAPASPKAAKAEQLSASSTKQHTHDPSSIPSIVPWQPELWCHQFPRDRKMMVGTITATSPLPTASDTKLTYATHPHIIEQLLDYVDTDTLFAFRSTCRRLRDEVDLVFESHIELHMEGLQLVFETPARRVIKAQRIPRFFNPALHNIRLDVRPSLEGFSYHSENRFDHHITNFAVHHTVADWFAKFLSNIKILDFHGGILMNILPGAPPRKGPDALGEVAVKSVKVPKLRFFPDGQSDCGFAAAVPFYADVVEYHGNLHLTHQRIDGSWLFWPKWVPQCEGVVHHVMLGINQKFSISPERVKPFVYPPSVKKVVVLLCVVKPPNLTTLTIPGCTAEERCIPIVTLLLILQRICGALQPGITWEMYGFTGTKLATSQAPGGILTADRVPNTVMLYLVRLQAAIDKEELKTDEDYQRKAAEMWGRVIFHGQTIGPQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5C7</accession>
    <name>K1V5C7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5C7"/>
    <dbReference type="STRING" id="1220162.K1V5C7"/>
    <dbReference type="eggNOG" id="KOG0506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027932_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5C7"/>
    <dbReference type="OMA" id="RPRNPFI"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000005">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002134">
        <property type="entry name" value="PRK00971.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="378"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="56064" checksum="C8795B35471A57EC" modified="2012-11-28" version="1">MSPPVTDVRTVDGIGRKIDGCGPSRSNVAFKGAKMQTPVSDYLKSVMEFCSVDNPGQNASYIPELANADPDRIAVCISTVDGFVYSSGDADVEFSIQSISKAFVYALALEDHGLQYVTQRVGVEPSGEAFNELSLESDTRRPLNPMINAGAILTHTLVGPPDISEPERLELIRKGLSAFAGRELQIDEKIYASEMKESYRNRAIANMLRNYHVISGEPLEVVDGYTRQCAISVTCRDLALMAATLANGGIQPITGERVCRPDVVRQVLSVMMTCGMYNGAGDWVSQIGFPAKSGVAGGILGALPGQLGIATFSPRLDTHGNSVRGVRMCKKLSDDMGLHIMHAPEPSRSVVRRHYILESPECADALASGGKAQHTAGVLSLQGTITFTSAERVLRILSRRSALSNSSVDAVVVDLRQVYSIDGVARKMIREAIKRLSKAGFKVLVVDPENLLDLVDDHNNPDAECPCDAVIDDLSRFADWHRVALPDVSDEIKDITGHEGTGASNGKSKPKDIPKQSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1V699</accession>
    <name>K1V699_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V699"/>
    <dbReference type="FunCoup" id="K1V699">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V699"/>
    <dbReference type="eggNOG" id="KOG2902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041558_0_0_1"/>
    <dbReference type="InParanoid" id="K1V699"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000071">
        <property type="entry name" value="Dihydroorotase, homodimeric type, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="319" mass="34870" checksum="34FDBF47B6EDB9E1" modified="2012-11-28" version="1">MYASKLTDQPNLVPPLTKTERVLEYKAELERIDPSVEWLMTLYLHPEVTPEEIRKAAAAGIRGVKSYPRGVTTNSSSGIEDYSVYYPVFAAMEECGMVLNLHGEVPSDAEKNISILNAEKHFLAHLEKLAADFPNLKIVLEHATTAEAVETVKKLGPNVGCSITAHHLYLTVDEVAPQPHHFCKPLAKEPRDRKALQDAVRSGNPKFFLGSDSAPHPSASKAPKISESGELHACAAGCYTSPYLVPLVATLLESFGALDQLENYVSKHGRAFYGDEAKTGQEVTLKRAAGSKVPPRITAEGIEIVPFWAGKELAWEIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V781</accession>
    <name>K1V781_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V781"/>
    <dbReference type="eggNOG" id="ENOG502S5ZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021058_0_0_1"/>
    <dbReference type="InParanoid" id="K1V781"/>
    <dbReference type="OMA" id="REDIGWE"/>
    <dbReference type="OrthoDB" id="2586454at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="66833" checksum="1EE6A07DE5D66191" modified="2012-11-28" version="1">MSKLPLPDHHPSRILFTEYDDAPSSSSSSASSTPMSVLRYLSQPKAASSRTARGTSDTPTLTLRVPNYGILFVPVPEQPSGEFEEAKPREDHVLAGELEVQLRDARRVKRIRVGLKTVMIADFGGKKLDEDVLFERKVEMIGGNSEGLWLPSGSQKFKFSIIVPANHPVHDWHPNAKITHHLYAELEGLPNAAAAPPRVGSSSSLFSFMGGKRSSPPHSSRPSRSGSPAPGSAGPRVGSPPRSGTSTPVSATSAAAGPMAIEAALAGLQVATGRSGISTAPTSPVGSPGAEVDDPIHKMQASSMSITRQEVFPQAPAYESKGEPEWLTGTVHTKRSIMLMYNPDPQGGVTEYDDCANGYAPGLGIWNARFSSDVWTVCAVMKFRFSLDSIPPTATIFTVRLALEQTHTIVSPRDAGGEAKKVITTRHFALHESGRRPPQGTIYPGKDYIAAWRGPAAGGKEVCGPDGGKFSIDTNVRLPKDDVARPTTPEGVVTPITVTHKLLLEVFFSVYGEDDRGKPLKSPGPGGLRMLRVSRPAMIPSCSMIPPILNLPTYEAHVHDPLASDDPVEAAREDIGWEWCACGQKLEDMEARMRSHGIMDECSRNRISADDKIWAERGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7A1</accession>
    <name>K1V7A1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_05849</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7A1"/>
    <dbReference type="FunCoup" id="K1V7A1">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V7A1"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="InParanoid" id="K1V7A1"/>
    <dbReference type="OMA" id="STRDIML"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="41"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="290"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="441"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKC99884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="573" mass="62300" checksum="839F4FA1573A88B9" modified="2012-11-28" version="1">MSGNGEVRMLGVTPPISLDPPKEADVKASEVRVGAGAQSPLLSNIAQLVTKFVHDVSIKNGLSEKVATEAGGRIYTSAFRLGVHGPGSDIDTICVCPKHVYREHFFGEFQQMLRDWPACTEISSAFVPVMKTVISGVEVDLLFARVNLPEAGDKLDIEKDEILRGVDDASQRSLNVTDMILNLVPDVATFRTALRTIRLWAKSFPGGVAWALLTARICQLYPNAAPSTIVSKFFPIYYQWMPVITPAYPSMCSTHNITQSTMTIIKNEMLRDKIVNNPGSSWVELFTPVDFFSLYRTYVQVVASASSAQDLKDWLRTLVQDLEMTDNVLLAHPQVNGISKTYICLTEEEQAQASQGELPPEAMMRKEEDYADKEHTKVYTKNFFIGLDIEKKPKDGQQPRQLNLYYASKRFCFACQSWDKYNEQDMSVILRPCKRSELPAFCFPDGQPPKKKKGKRAQQEKVGDAALATEAEGGQTGSQQAGESAGEITDEQGPSKRSKAEPDPNGAVPVPSATGADPAPNDASAVADVKPPPGLEGVPAPSDAAKAAYASAANGVASDPSHNADGKVVLNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7J2</accession>
    <name>K1V7J2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000354">
        <property type="protein sequence ID" value="EKC99969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7J2"/>
    <dbReference type="STRING" id="1220162.K1V7J2"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="K1V7J2"/>
    <dbReference type="OMA" id="GHTMARW"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="54133" checksum="7005D2BB37F1BCD0" modified="2012-11-28" version="1">MTTTPTLQRTTSPDRRSSIEKYEDDKVENVDVAVLEAAEEDKRAGDYSGFTQKTDPAEIKLQPSLWGMYWLNYLDRNAIALAKLSSIEKDLGLSDVQYQTAVSILFVGYVFVGVPSNMLITRLHPGYYLCAIMLTWAVLSVCTAFARNYVGLLMTRFFLGALEAPYYPGALLIISNFYTRTEVATRIAILYTGNILATAFAGMIAAGIFQLDGKRGYAGWQWLFIIQGAVTGLVAMMCFPFLPNKPHNTRWLSPEERVLATDRLLRDKVDEGPKGSPWQGLKQAVSDYRVWIFIFAFNMHLSANGFKNFMPSVVNTLGFSQIITLCLICPPYLLAGAFTLYISWSSGKHNERTWHITVCKIIAIIGFALAPATLNTGVRYFAMVVFSVGTYGVNSILLGWAATVCSQTQEKKAVVMALMASIGTGSFIYTPYLFRDDDKPRYTIAMSAMAVFSLMTIIATWALRFILKRQNKRIAETGSPTKYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9A8</accession>
    <name>K1V9A8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9A8"/>
    <dbReference type="FunCoup" id="K1V9A8">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9A8"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="K1V9A8"/>
    <dbReference type="OMA" id="LCEIICD"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000111">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="293" mass="33708" checksum="CF0196214F43DC3A" modified="2012-11-28" version="1">MSLSSDLDKQIEQLKRCEIIPEASVKELCLKAKEILMDEGNIQYVDSPVTFFDLMELFKIGGHCPETNYIFMDRGFYSVETFLLLLILKVRYPDRITLIRGNHESRQITQVYGFYDECQRKYGSSNVWRYCTDVFDFLSLAAIVDGRILCVHGGLSPQLGRLDQIRAIDRKQEVPHEGVFCDLLWSDPDGWGMSPRGAGFLFGGDVVETFCHNNDIDLIARAHQLVMEGYKLMFGQKIVTVWSAPNYCYRCGNVASILELNEDLRQEYKVFEAAQPDVKSVPQKRPHMLEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9S7</accession>
    <name>K1V9S7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9S7"/>
    <dbReference type="HOGENOM" id="CLU_2943467_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9S7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="60" mass="6670" checksum="4B6CC61E03F6E530" modified="2012-11-28" version="1">MFKVSRIAPPPEYEPKMVEEDENGMELDGPAGSSVVTPGEGIASSKEYMRDTFELVDLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAC6</accession>
    <name>K1VAC6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAC6"/>
    <dbReference type="FunCoup" id="K1VAC6">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAC6"/>
    <dbReference type="eggNOG" id="ENOG502QQD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="InParanoid" id="K1VAC6"/>
    <dbReference type="OMA" id="NVSAYCR"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="574" mass="60792" checksum="8CA890CD85AB5E8E" modified="2012-11-28" version="1">MSHTPESKLDTDTYSTKEISTVDVSPVESIPSSSLGHIPKRRFSPKSIAKSLVSKQAWFGDYDYAALFTPNIPFLCKSGQLPFYGVEDELPHLLTFILGLQHALAMVGGLVVPPLLLGGPAGANLGSSAQMYLVSACLIWCSIGTAVQISRHRIRGTKYYFGTGIISVVGTSFTFANIALKYFSQCYENGTCPTAPDGTKLPCPREFGAVLGTGALTGLFAILLAFVPPKAIQRAFPPLIIGTMILFIGASLVTSGITNWAGGSGACKTDHTLLCSSGSQSHHWGSAQYLGLGFSCFSVIVICEIFGSAFMKSASVFIGFVTGMIIAAATGYFDGQVIQKAPGGTFLFVHTFPLGLRGQLVLPMLASYAVIVAESIGNITASIQASNMPLEGPEFLSRIQGGMLADAVSAALANLCTITPLTTFAQNSAVIALTRNASRRSGYMCAALLFLMGIIGKFGAIFVAAPPAVIGGFTTFLFGSVAVSGIRIMAFAKWTRRDRFIATTSCALGLASLVSPHWFNYIFTYNGPNTSLRGFLDAIILIVEEPYLISSIIGVFLNLVLPAEIEENTPAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAN5</accession>
    <name>K1VAN5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General APC amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAN5"/>
    <dbReference type="STRING" id="1220162.K1VAN5"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="K1VAN5"/>
    <dbReference type="OMA" id="AICCASV"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="58"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="563" mass="62830" checksum="60D8E9D4478B7C7A" modified="2012-11-28" version="1">MNEPVKDVIDDKGVTDVYPITSLRDAEAGDDYDAEKDVKVDVHTQLYDGVQRKMEQRHMQMIALAGTIGTGLFLNSGRIIAHGGPVGALLAFITTGTIAYGTLMCLGEMAVYAPISGGYIHFAERWVNPAVGFAVGWQVTVQYCISMPSEMIAANILCSYWDTGFAVSHQAAYITTFIVCGSLVNYFGARWFGESEFWTDGRFATMKIILVIILIITSLVIDLGGGPKKDRIGFRYWKDPGPFAPFYGDDNLGYFLGWFTDLVQAAGSYMGIEMVIVAAAEVRNPRVALKKAVKRLFWRILIFYILLIFLVSLIVRYDDPELLQSKGTAASSPFVLAMKRAGIQGLPHFVNACVLLSAFSSGSSLMYSASRMLYGMALRGYAPKFFAFTTRRGLPLYALMFTTCFYPLAYMSLSSGASTVFNWFSNLTALSGYVVWATIGVTYLRFKAGLAAHGIDRKTLHYANRFQPFIAYYVIFWAVVILTFNGWQVFTKGNWDPSDFVIAYIPVPIFLTLVTGYTLVKRPKWQKPSELDMYSNIPTDEQVAYEEPKPKNAFQKVVQFVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB78</accession>
    <name>K1VB78_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB78"/>
    <dbReference type="STRING" id="1220162.K1VB78"/>
    <dbReference type="eggNOG" id="KOG2883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053393_0_1_1"/>
    <dbReference type="InParanoid" id="K1VB78"/>
    <dbReference type="OMA" id="NESSWFR"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="214"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="32245" checksum="C4E1FBD2BCD3F63D" modified="2012-11-28" version="1">MLRRAAINSPASALRSLVSPSTRSFHATVIARDPPNKPTSSEAAATAKDEEPTPSSSGRSLLGSIIYGSESAKAEGDVRLPPGQHSKIVGRGKYVHEKITHAVKPGHRDAYIKACEEYFATLMRDSKDLGGVKLCGSWETIIGSVGNFVHILEHEGYAGYDETRRQAQKNETLQAHLNAMLPHLESRQHQMVSEFSFWPSSPPKDHGAPDGGIYELRTYQLRPGKLLEWETAWRRGIEARRRYVVGQLHEVHHIWFYPDMSTRKQLREAAWSVSGWGETVQQVRVDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBS0</accession>
    <name>K1VBS0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBS0"/>
    <dbReference type="STRING" id="1220162.K1VBS0"/>
    <dbReference type="HOGENOM" id="CLU_1929078_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBS0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="131" mass="13971" checksum="CF56B1B4DF6EEBEF" modified="2012-11-28" version="1">MASKLAQLLTTARALPPTPFRASGPQLTDAIEGMASRAFNMPAKSDVRDVEAKTLSSYEEERVERAIAALGRLRQGEALRERLWPSRRLLDVGVVPATCNGEGGGQDLAANHVGSESHGWLGLPPPTTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDW9</accession>
    <name>K1VDW9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDW9"/>
    <dbReference type="HOGENOM" id="CLU_872059_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDW9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="319" mass="35560" checksum="F4C9A8E7FA04422A" modified="2012-11-28" version="1">MDYPAVVACAKSSRLWGERAMDYVPHVALIEFEDGSVVLRSRDLEWPEASAILFRPCSFLGSVSKVLGGFEVVDIFFNTDDGFKTAFKSNEWPLNYLRYTTYDVWPPFHDFPTPDENEPEEVRSATVFMEYRNGHFFYDTVLAVVPCNITSLTLTVHCYSNPTMSSPLVTTGHVNTLISLFPGLEAVKTFTVILTGSEASDPSIEPDEQGCGCCDIDCAETVLTLASTSLVADCGALCELALLAILMPKLKALYIVGTELFRDVTGGYGYLYWGPFDAALDQEASFNDRPSVSAKIDPMTHKAYEEYVEERRYRLQTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDZ1</accession>
    <name>K1VDZ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDZ1"/>
    <dbReference type="STRING" id="1220162.K1VDZ1"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005231_0_1_1"/>
    <dbReference type="InParanoid" id="K1VDZ1"/>
    <dbReference type="OMA" id="TPHVHDI"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="3">
        <location>
            <begin position="214"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="877" mass="95199" checksum="0B083B2C658C1856" modified="2012-11-28" version="1">MIRSLSRPTSRVVQLHSGYRGLSSSAAALATLGMRREDPRRVWERRAPLTPDAIKSLVKNKDNKVEVESCERRCFTDEQYEAIVPKLSNAVDVVLGIKEPRVQDVEELIARDDKKRTWMMFSHTHKGQPYNTGLLATFLPPTKGQTLIDHELLTAPTKDGKLKRVAAFGWYAGGLSLTGLALLKRGIAHPLLHLPRPYTFGSMEEYKAALKATGEAAKAGKPLDKEGPVVIGLTGAGNVSTGAKDMLDALGVEWVEAKDLPNLPNTSTIPPSAYFERKEGGGYDRSEYYAKPELYKSTFDEKIAPYITTLIHGAGWSAGYPRIMTNAQTDAFIKSHGGAQKLIGLQDVSCDIEFMNKSTTIDEPYFDGPGGMLIGSTDILPTELPADASAHFSKHLYPYVERSLQHYDGKGRMGDEIDKTLARAMIVEDGELQKPHDWLEKNVRSWKKAAPGGGCQKKRVLLLGSGLVAGPAVDVFLARPDVSPVIGKLVTNVTTAMLDVSDERALSEAVSAADVVVSLLPAPMHPQVAKHCIAHGKHLVTASYVSPEMKALAKEAAMRIMERVQREGKRVTSFISWCGGLPEPSASNVPLAYKFSWSPRAVLTASQNDAHYKLDGIEHTVPGDQLLAKHFPNVDLWKGLKLESLANRDSMPYAAKYGLGPVEGLQDLYRGTLRYQGFSKLMDAFRRLGLISQDALSAPVESWPALLAASMSKATGEKVAEKDLVPAIRSLLGKDADSALDALKYFSLLPESVSNAPALPRAQAPIDYFASLLSNKLAYKPGEHDTCLLYHGFRVVPEGAPEGTPEQTVSASLLCTGNEKASSMATTVGCTLAFAALRVADGKVDARGVQGPYSKDVWSGVLDELANIGVEVKETWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEL3</accession>
    <name>K1VEL3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEL3"/>
    <dbReference type="FunCoup" id="K1VEL3">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEL3"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_3_1_1"/>
    <dbReference type="InParanoid" id="K1VEL3"/>
    <dbReference type="OMA" id="SITKYHE"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="341" mass="37719" checksum="E92579D4748172F6" modified="2012-11-28" version="1">MTAPTPLYTVPIDRRPPGYGPLFSKILFPVVFNLGILGLNSLQFLCLLFKLIPGDTGKRLYRSSIDWTKDGFGRLLIAITTLCAPTSFVITADSPLQLEKIVQRDADGQVTRLNLPDHLIVMANHQAYTDWMFLWILACYSGTAEGITILLKASLKHVPFVGWGMVHLFEALMGGGPPESHSFLKTDCTGYIRAGQAAPADDFVGVLHPRSTGLLFCLRTLLPAVPDLQLLDVTIGYPGVPFGKYPQEWYSLTSVFFRSVPPPTVRIHLHLHTNLGKTGGDVPALNDLRAGEAATPEETREFELWLRGIWAKKEAMLEQWSHEPPVPDAPPAFEIVPVQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1VES7</accession>
    <name>K1VES7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VES7"/>
    <dbReference type="FunCoup" id="K1VES7">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VES7"/>
    <dbReference type="eggNOG" id="ENOG502QSCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005117_0_0_1"/>
    <dbReference type="InParanoid" id="K1VES7"/>
    <dbReference type="OMA" id="CRRTINI"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="910"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111857" checksum="7962B2EE2C9654B5" modified="2012-11-28" version="1">MQRDFDERDRHDSRFPLPPERPSHRSAFLHGLPPPMPPSPRGYYPPSPGKREAPSPGGGMTDPNGWSSGPPMNGSRSAMERDMSSAGSARSRWSPPPMHMRNMSPRMGDRLPPLADYPPMMRHHWDSTPHVLKPSSHPPHDPNRSPHSHPSSYRNQGTPGPEQQRESAYYRPPTAPSRGNTRSPESRVPNGNVIATPEAINGNATNPSNNPSAPANGTKHPAPAASSTDPPSEPPKKKKRRQAFSCAECAKRKQKCNRETPCQHCVNRKVPHLCIPSSRLNSPPSRAKPAAKTDGDKSAATGKTDERTTTTPMPALGGRVSRIERMLNAVLNRIDGLDSTALADWRLLHARAESPPPQHGADVKRPPLQINGSSNGSLGSVVSMQSSITGSVGGALAGNDTLANQVVDSGPWSVLQRTSQTDLPPHEEANALIAFFFSDINDLHYPIDKRAFLRAYDALYTSNLEEQTSPATLTALPLVYAVLAFAYRLAPDHLVPGGERDRLKRSQQLVWNAKCTIPLASSISEADATQLVEARLIEARIILGLYQLQVERALEDAWVTFRTAIAMGTAINLHRDGSQLGLDALATEYRRRLWSYLCHADATTSAIVSHPMTINPTSYDADTPSNVNLEELTVHAVKPKPMDEPTTATFIVLRSQLAHIVGRITSQFQRLRGSMHYDEVLSIDRELQDFTDSLPPQFRIMETDTSKDKGELRTSSRGTDHSDLPHLTVQRLFIQSEILHYGIVLHRPWALRDFSKSPEKHAHSRNRLIEAAILTLKVRGGYADAKVPEVLEPLLSGSTYDFNAAFIAGLGLHADPSCPRCPDLWDIMEKYTRQHPYDPDNKETVIVYTFYRRALQDKENRCRGGSDSARPTMANLLVNGKQGNDDPQQLIDQFLSANAGFIESRRPRDLTALGFGAPPDPSPSSVKNEQEEKNPSLSIGAVPARLIKVQDGQTAEEVNTPEFFNRLIDGEYMIEITRRLVAFKPPGEGLFFIPAETPECLLMTAIHQYRAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF50</accession>
    <name>K1VF50_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_08003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF50"/>
    <dbReference type="STRING" id="1220162.K1VF50"/>
    <dbReference type="HOGENOM" id="CLU_1918547_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF50"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="132" mass="14571" checksum="E890A72B341C7755" modified="2012-11-28" version="1">MTRHGSCLCVRPGQRHQGRHRLLLLQLPEDGHGWVSPDDVKVTKGTPKVYQDNSTRSGKPMARSFCGDCGTPLWSDPSATPGVRYLKVGTLEDPHSVDLKMELFVDKAIPSTVHPQKGQTQLDSQMQPVKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFN7</accession>
    <name>K1VFN7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFN7"/>
    <dbReference type="STRING" id="1220162.K1VFN7"/>
    <dbReference type="eggNOG" id="ENOG502RH7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1332761_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFN7"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="21848" checksum="7F3CC47C30B69754" modified="2012-11-28" version="1">MASSSSSSSQANRPPTAGKPDRLYVGNLSQTVDEYTLLQVFGKYGKITRLDVMYHKTGPQKGKPRGYAFVEFSNKDLHDRLLRGKKLIVTYASAAPAEDFLGPKVRRIDAPKPTALSLLKTSKKPQSAADRGDGGEIGPASETTWPLAISAETNHRNGGGGCGECARGRDPAGAAGWRRRDVRVLDAGKGGADISLGLAAKALRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFW5</accession>
    <name>K1VFW5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD02990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFW5"/>
    <dbReference type="STRING" id="1220162.K1VFW5"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778870_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFW5"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="382" mass="41955" checksum="BBA706C6B6A3AC13" modified="2012-11-28" version="1">MPPLPTYGKRPVVLLTTPATCTNIALHNLYPGEIDLVISGPNHGRNSSAAFAMSSGTIGAALAGALSVPIEGPPSQASLHVHNMPSIAVSYGVVTRPVPEGCMEMAADIAVEVCRRLFEDWGWEDAEHKRPVQLYSVNIPLVPEHLAPENRRVCFTTLYRNTYGKLFEETDKITNDVYNPTQHRGPQPERHDGQLRFEFKPSFQKILNPDPKDVPKGTDAWAFQNGYTSVTPLRAAYGEVGAEGSGFGDKSDIGLFWDLLCLVDGVQDVTLEHEDEVEPEREQGQAELSGVGPNTSGLAIDEHGLDDELEEREHASGKVAEDGADAEPARVLDEEVQRHLRQVFQDRDDELDAGDIVQEIEELDAAEMQRGQLPERTNCNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG62</accession>
    <name>K1VG62_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG62"/>
    <dbReference type="STRING" id="1220162.K1VG62"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="K1VG62"/>
    <dbReference type="OMA" id="VAITHRF"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="503" mass="56743" checksum="B06B8D929D1DAE27" modified="2012-11-28" version="1">MSVAYAVAGVFVAWLLYIFFPAVKSRQWFAHQLNGPPSPSFLTGRFFIDFWQKDHAPHMGHVQRYGKIFKYPFALGIPMIFIADPYIVSDAYSHPDTYKKTKGMITMLDNLFGRGLLSADDDFHKQLRRIIAPAFTPSIIRSLFSEFLEEAYRLQERLQDKVKENNEVDILNELSRTTLDIFGTTGLGQDQLGDPLNRLGQAYTSLIGALTADMGKLGMLQVIITQLQIFPSAMMRMIKTSRAIIESKGKQMIAQAGQKRDKDLLSLLVKSNSNESASKQLSEQQIIEQITTILFAGHETVSTSLSWTLYHLADNPSLQTRLHDELSELPEEPTFEQLDACPLLGKVVREILRVYPPVPSTQRELAVDQDIPLSEPVALKDGRVITSLPLKKGEVLNLSVVCANRDKDVWGPDAEEFNPDRFDRPNTPAKQIPSAWGNVLSFSHGSRNCIGFRFALAEMKALLFVIMRNWRVERVCPVEHRNGITSRPYVDDKPSCPLRLHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG83</accession>
    <name>K1VG83_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide riboside kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG83"/>
    <dbReference type="FunCoup" id="K1VG83">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG83"/>
    <dbReference type="eggNOG" id="KOG3308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058668_1_1_1"/>
    <dbReference type="InParanoid" id="K1VG83"/>
    <dbReference type="OMA" id="FMSIPYE"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28984" checksum="8DFF883F5581DD29" modified="2012-11-28" version="1">MKNRVIMVGVGCSGKSLLTTHLHRLAPSFAVHQDDFAPAQEDIPIHPVHKVQDWDDPPTAIDWARMRSVLRHVRSNGRFEDGYKSYQHLNDAVEVGVDEDATIRLRREFAKIQKHAAQKGERLTYVLVDGFMLYYDTEVQDNLDVKLLLRVPRETLKKRREGRHFPCVVAELTSDAKDAETGATWVDPPEYFDNVVWPAYIKAHETVFDPSPDGPLKDKSITLLEPGEGQDEVTRIVDEACAAILGAYERGLGNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG97</accession>
    <name>K1VG97_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_05805</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG97"/>
    <dbReference type="FunCoup" id="K1VG97">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG97"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007267_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG97"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="896"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="968"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1039"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1072"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="119"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="439"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="686"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC99840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1149" mass="124316" checksum="D8EA0B5808FE4205" modified="2012-11-28" version="1">MALAFRAAAPGRVGLGSASATMAHRPGFMTLRTLSTTPFARPSPPLSRISVFTLGKRFESTTTSDSEKRKNAKDSKAEVDVLLASTVTPPPVKVDAKPDTASLWKLLSLAKPQKKLLTLGVSALIVSTGVSLSVPYIIGKIIDYFAPGSKETLLFGLPLEQAAVALAGFLVIGAVANSIRSISLRLAGQRTVAQIRNKTYKQYLALPPSHIETAGVGDALSRIGQDSSIVGQSLSENLGEGLKAVMGAAVGVGAMYMISPKLCAVMLILFPPISIGSYYYGRYIRKLSLKTQEALGNMSKLAEERLSAHRTVTASNTQPSERALFAGKVASVFNLQKKETYANGIFQGGNEVAGDLAMIGLLIYGGMLVQRGEVTVGDMTTSLIYVNWIEWSLNTLATFFTGLMRGVGASQRIISLHSLPSPVPLSVGAPVEEKDGGAIELRDVAFAYPSRPDVRVLDGVNLRIDQGEQVALVGGSGSGKSSIQLLLLRFYDPTDGQIKFGNKDIRDFEPESWRGRIGYVPQDPILFAGTIKDNIKYGHPKATDEDIIKAAGIAHCDFIERLPEGYDTVITKASLSGGQRQRIAIARALVGNPSVLLMDEATSALDSESERAVNAALDALFNDTDITVILIAHRLSSIAQADRVVYLEGGHIMEDGSYDDLITRPQGRFRKMVQGQMAKIADPIQEETGAAHEPEEPAKPKNEDEQPGITMRAAPASPFAGQKRFAHTSATRPEAEQEPEIPQPPKYRTVYGAANAPASPLPEVDLPIPSAPAAPLSSYKPLPEQTPKRLINLYSQLSKRNLSILMTLTATTGFALSPLPLSMPVLLALTAGTFLTSAAANTFNQVLEGPIDAQTPRTRVRPLVSRRVTPFHATAFGTTCMTLGGAILWYGCNPTTALLGIGNLILYSAVYTPMKRYSVWNTWVGAVVGAITPLMGWTATGGSLWPTAEQPLLLHWPFSNLPDLPNPLAAWTLALLLFSWQFPHFNALSYMIRPFYALSGYPMLSVLSPRLNALVSLRHAVLLAPICAVLAPLSGAVDWSFALTSAVPNAMFIASAYRFYKNINEVTAKKCFFVSLWYLPVVLGLMLLHKNLRKWWTQESDWENSDAGKNYIHEREHARGRILSERHLPEHTHRVDVTKQPPAAPTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGT2</accession>
    <name>K1VGT2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGT2"/>
    <dbReference type="STRING" id="1220162.K1VGT2"/>
    <dbReference type="eggNOG" id="ENOG502RAA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172736_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGT2"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="90" mass="9502" checksum="FD45A7924FC0F404" modified="2012-11-28" version="1">MSYTIAGRAIKSFPRRPAPSPVIKLIRSALGTIFSTIGIALASSGGDKKEQAAPPAAKDDTSINTGNKEEDDFIRQFVAAAEEKGDDGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGZ5</accession>
    <name>K1VGZ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGZ5"/>
    <dbReference type="HOGENOM" id="CLU_1316229_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGZ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851863" evidence="2">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="209" mass="23629" checksum="E214BF55E9209E91" modified="2012-11-28" version="1">MSFDFIFFQLIPMALPTILASPLSDVSLELGLLNGAVGLVGFVYANFFGLNSSTTRFEINITRALYHCSLSCIGICLMSVPTWQFLESAETLYHIILYFASALVVIPTLSAYNGHGFNMTFDYIRRGLFWMCMAHFIITRMFTTLVAYVVWRSEGLLEDPARRNLFYNNTCKAYLPVLYAFPAYAVFGYIPPMNAAQHANKIASWFCAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHB9</accession>
    <name>K1VHB9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Xenobiotic-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33503"/>
            <dbReference type="ChEBI" id="CHEBI:6076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33504"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VHB9">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHB9"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="K1VHB9"/>
    <dbReference type="OMA" id="FNIFAAC"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1286"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1368"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1490"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="177"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="876"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1576"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1576"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1628" mass="183007" checksum="B7317694FC8BB710" modified="2012-11-28" version="1">MSVVGNFNYGSYDRQEQHAGASPQRKMSFSQDWGFGQSNQGHDDVEEFIPTQEQRHAEVVQLARQISRQSQRSVTRPSLSHDHQHDIQEGGSGGTTTQADSEANDGDIFNYEPGSDLDPYAEHFNIHKWTRAMTSHMAAANDSRVSGIAYHNLSVHGFGSDADYQKTVGNLPLYVLGQIRDLIGHRKHKVEILNEFDGIIEPGELLVVLGPPGSGCTTLLKTIAGEMNGIYLGEGSEINYRGIDPKTMNKRFRGEAIYTAEVDVHFPKLVVGETLEFAARARAPRHPPAGISEKEFAYHMRDVVMSVFGISHTVNTVVGNDFIRGVSGGERKRVTIAEATLSSAPLQCWDNSTRGLDSANAIEFVKNLRLGAEHFGTAAAVAIYQAPQHAYDMFDKVSVLYEGEQIFFGRTTEAKAFFERQGWFCPQQQTVPDFLTSLTSPSERRAAEGYEDKVPRTPAEFAKRWRESPEYAKLQADIVAYNKKYPVGGQYYQDFLASRRAQQSKHTRAASPYTLSYWGQVKLCLRRGFWRLKADPSLTLTQLFGNSVMALIISSIFYNLQPTTASFYSRGGLLFFAILMNAFGSALEILTLYAQRPIVEKHSRYAFYHPSAEAFASMLCDMPYKIVNAILFNLIIYFMTNLRREPGPFFFFFFVSFILTLTMSMFFRSIASLSRSLTQALAPAAVAILGLVIYTGFAIPVNYMHGWSRWINWINPIAFGFESLMINEFHDRDFACAQFVPTGPGYPTGGDNVVCSSVGSKPGLSYVNGDDYINIAYEYYHSHKWRNVGIIFGFMFFLMFVYLAATELISAKRSKGEVLVFPRGKIPKELKDANNAYVIEDEETQMSVGTRPGLEKSEKTGLDAADGLIQRQTSVFSWRDVCYDIKIKKEDRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDVLATRVTMGVVTGEMLVDGRQRDASFQRKTGYVQQQDLHLETSTVREALRFSAVLRQPKHVSREEKYAYVEEVLKLLEMNDYADAVVGVPGEGLNVEQRKRLTIGVELVAKPELLLFLDEPTSGLDSQTSWNILQLLRKLTHENGQAILCTIHQPSAMLFEQFDRLLFLAKGGRTVYYGEVGAGSKTLIDYFVRNGAPPCDPSENPAEWMFSAIGAAPGSETNIDWHKTWLESPEYQGVRQELHRLKYEGRAKPQPDKKDKSAYAQFAAPFGVQMFEVLRRVFQQYWRTPSYIWSKIALVVSTGLFIGFSFFKADNSQQGLQNQLFSVFMSFTIFGQICQQIMPNFVIQRSLYEVRERPSKTYSWVVFILSNIIVEIPWSILVGTMFFFEWYYPIGYYRNAIPTDTVTLRGAMAWLFMQMFFLFTSTFATMVVAGMDLAETAGNIANLMFSLCLVFCGVLVPRQQLPGFWVFMNRVSPFTYITEGFLSVCVANTNVVCSDAELLRFVPEGGQTCGSYMANYMKAAGGYLVDPNATDSCRFCAMNSTNTFLSMFNIYWSNAWRDFGLLWVYVIFNIFAAIFLYWLIRVPKHKKAVEDDNDGLDRATTVGSNMTRQQTNLSRQQTGLSTATNEKASVYSPGHPTIVEQSNENFASTTTLPTSTPDLLSNVNQLPASKEVQEPIDPGLKTVETTKVESPDNYDSKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHL2</accession>
    <name>K1VHL2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHL2"/>
    <dbReference type="HOGENOM" id="CLU_2198837_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHL2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="108" mass="12375" checksum="991211A529C886FF" modified="2012-11-28" version="1">MNISSPDSEPDTLESQLQAQAAAFQQAFQQLVTRYAEDCSVIVQYYSELPSEPPSENSLRLNAALRQIHQRQEAFDKDLQSLHKGFKHNVDLICGDHFQRIVRDSQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHX2</accession>
    <name>K1VHX2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHX2"/>
    <dbReference type="STRING" id="1220162.K1VHX2"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074885_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHX2"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="244" mass="27136" checksum="864C04521324BDE1" modified="2012-11-28" version="1">MSDEKPDKPCTLTLADGTHFDLNPLSSAKQDYVANSGSNDTVYKLNVCRSVVSELWNVDDPDKVGGVVKREGGEHHGQHESDPRTHDSAADDVPRERVQVPAERERACLDGHQVAIVSWFAGQTLYNRLKLGRRGMDQFPIPHFHKPSVQLPSFRGHGEEGGAPRPRWGVFKRRSQRNGYNHLRQDPDEEDRLAASRFSLDDDEEADVGAEVNAWRTPDVSGRASDENQRPSGSVGVHQGLVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI88</accession>
    <name>K1VI88_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI88"/>
    <dbReference type="FunCoup" id="K1VI88">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VI88"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="K1VI88"/>
    <dbReference type="OMA" id="KIGGYPP"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="310" mass="35197" checksum="33C11A6EF42CFB21" modified="2012-11-28" version="1">MAPFDLDACIERLKDKQLLGEALLREICEKTKEVLMRESNVVHVSSPVTVVGDIHGQFHDLIEIFRIGGPAPSTNYLFLGDYVDRGLHSVETISLLTCLKLRYPERIQLIRGNHESRAVTQTYGFYLECTRKYGSPTVWQYFTDMFDFLTLSVVIDDAIFCVHGGLSPSIHHIDQIKVIDRFREIPHEGPMADLVWSDPDPEKEDFAISPRGAGYTFGASIVKKFLHLNDMNHVLRAHQLCMEGFTRLYDDTLSTVWSAPNYCYRCGNMASILEVSPGGHRFFNVFDAAPENERDGPTQQQAAKAIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI90</accession>
    <name>K1VI90_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI90"/>
    <dbReference type="STRING" id="1220162.K1VI90"/>
    <dbReference type="eggNOG" id="ENOG502QUQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006242_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI90"/>
    <dbReference type="OMA" id="DCIRRWE"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="697" mass="77625" checksum="6ECB07A408220A32" modified="2012-11-28" version="1">MTPEYYNHWAGSGVGRPVAQTLPGVGTPQATPPSYRPIYSPAGAPPPVAEGTSPTGSDPKKKRRRRADGSPGAEEKRTKTGRACDACRSKKIRCDILPSDGSDAQPICAHCKQYNIECTFFLPITETRFKKRRAANDDQNSAKTNGQTPPSAGPGRPPGPGSILSLVHPTAPTRSFEAYDIANHQNWEVSKDDEGKIKVRAFATGDEENSEKRRRLANHGLDENIMTNLINSYYEYDHQFLPIIPRDEFIASGKPHPFLLYCMCAVASCKSDFPRSVFTRMRGMVNGLLRANEIMSNPTIEHIQGLLIISPVGDLHAQPAAGTATAAAMRLGCAVRMAQELGLHRETKPPSNPTAADIAQLELKRRIWAACVYMDKWYAAHLGTMQQVDVHDCDVLVPSPYKIDPSVESSKWEIDPPLAHIGESMKLALLVGRVLKLVYGPAGMHHCTDEQLKALNTDLRQWAIDLPQVLRFKGRESSALAGLLHFQYLSAMFLFWRPFLRVVHPPPAHIKTILDLRSWHELVRGSKTALEWLDSHTHALDTIYFYAYSATSCALIQYHRWARKREQEALDTLKLVRDLVRRWEEAFNPDQMSMRRKSCETMNLLYEAALKTNPVENDTRSEASGTGSSGAVTTTSVERPAFGHRRGTSNINPNIEDLGNVEGEGPTQVSYRAAAERASVFDDAGDFDFFLPRRYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIE8</accession>
    <name>K1VIE8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIE8"/>
    <dbReference type="STRING" id="1220162.K1VIE8"/>
    <dbReference type="eggNOG" id="ENOG502RXTC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061244_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIE8"/>
    <dbReference type="OMA" id="HTIIPNG"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="28739" checksum="730A79B059B073F9" modified="2012-11-28" version="1">MTLHNDMGSLTLSSLPPLPSETDGATVEGAVTHVEVVDGRGFRNPVEGGGSMITRWLNPESLGEPLNLIVSGASDAEILVDQKLKGGFRNYMLSGYMSDEAFGLHLGDPQLADLGDGRGALKQVRELRHNYGEVLLGTLTETLIGGNHLRYWKQGGSNAYFLAASAEKNVQEHHDIVPDGYDLGRDQFVGKLVGYEIKGKPKAGDRFKGESHALGWTYETSVEYVDGLLAVDQATINHHDTVSVDGKTTDGLVALLTVRIKKRGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIJ7</accession>
    <name>K1VIJ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIJ7"/>
    <dbReference type="STRING" id="1220162.K1VIJ7"/>
    <dbReference type="eggNOG" id="KOG2053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372631_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIJ7"/>
    <dbReference type="OMA" id="RIFMIRI"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="774" mass="83833" checksum="EF845CF5BA8F9085" modified="2012-11-28" version="1">MALAEKTRRAGYADAVLELWAKVQETGWLTDRSIWLATVTLRSIDRLLEMHKKRWEERPRDATLGDPLFLAASTMGDYETMAAVSRKLFNQTKLSIWARMAAYSTYCQALSSNPTPSSSTSSSSSTPSFAGEGAASTAEAAFPLCPEKSLVAASLFLKTLPAVEESVDVFWLRLAVLIGGREFGEARALLKKEGHCGALARRWVSMQAAAAIAAYDESLRASVWEDEFATAAAVLKADPEAQSNYAFYRHAVDAVILGGVDAAKARTLFEDLRGSVKDRSPALALLELDGRLRASGKGESMSEPEWRKALESYLDRWGAKWTAGSEVAGVSVGFERAADEIMAERAARFATHASEADFVALSVAELFALKSRKDGSLEEAQRLWTLYESGLQYGANLPKTDVQPADPLGLAAVEHLLRVHHASPPSDVPLQDAAVLLETIVANSPSAAGARLALVCVYRRLGAPGVAAAHVEKLKLSEVQLDALGWVFERADDLRVAREAYWNDFAGKAEAMYARSRADLPQYITHALEHESYSKIRGIQQLVSNLDRSVGQVSLDTELLLRDLVSGASLDSSMVKRLVKAGSATLVDNRVYDLTPSSLSGQTPDEAQALARALTPIASWVADDEAALDAPIENVEGAGLVAGLTQLAQALRAAVKEEGDAVPLSSVFPSSLSRTEVATLVGVSDRLVARMTEVLPTGKKKKNKNGQLRKARLFELRDALRSVREHIPAQDSEKMSEWSPTMGDEERRKDVGDRVAEGRQALSAAIEAALKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK11</accession>
    <name>K1VK11_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK11"/>
    <dbReference type="STRING" id="1220162.K1VK11"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_4_1_1"/>
    <dbReference type="InParanoid" id="K1VK11"/>
    <dbReference type="OMA" id="WWYSTHH"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854179" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="345"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="804" mass="89843" checksum="F6B0BFA5700FE9EA" modified="2012-11-28" version="1">MMLKLLLLAVGALASQVPLGDAGSAPGAGAGASTPRSVQLDLSPYLNAKATSVNGENDGKGFRNGSTFPSEYLPIDRWSDSGVDFVLPDWSGTKDCVKADKQVIHLPDPTEVRSIHILGAGEDAGGFLFMETHETLTLTFEDGGKVHAPFEVKHWWSHHWTNKSPIRAPFHYLDEGVKSYNASHLFHIPVTIPPAAAGRTLTSVRLPGPAEKNALKVFAMSYVPVTSEVMAVQWARGTRRWENGHQIVEVLLTNPRSVSEHGDESSWIRDVGVKLQGETFKGLNERRVNRLMPGDEVLLEFEVEPRAGSSEAFDGAHLQVRYGDRIEEIPVEVSGVRLLRSPDYTEDEIEEHSRPGWYDGAKFGIFIHWGLFSVPAFAAPPQYAEWYDFWLHDGEKPTENHHRSTFGAEFNYDDFIPMFTADKYNASEWMDVIAASGAKYFVFTTKHHDGFAMFDTKETSDRNSLLLGPKRDILKELMTAAKEEHPELKRGTYFSLPEWFNPLYAPHGRLSFPGGPALNPFTREEEPFTGQRESATDFIEDIQRPQMEILVDDYDVDLLWCDIGLDNHSSAVFSRWYADAARQGREVAINNRCGVGGDFDTPEMTRFATVQPRKWETCASMDPHSFGYNKDTKDEEYRSAEDVVHSLVDIVAKGGNFLLNIGPRADGSIPKAQSEPLREAGEWLKLNGRAIYDTTPFEPYPEHNAAGVHVEFTRKPDAFYIISLKKPGRTLAISAPLPVLAGDRIVAIAPDGDKVVQWLYEDGTLVLDTRGIEFSDDGIAWVFEVQYADPRESIDESEPVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK97</accession>
    <name>K1VK97_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK97"/>
    <dbReference type="eggNOG" id="ENOG502S7T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105491_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK97"/>
    <dbReference type="OMA" id="DRISQYM"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16581" checksum="1013A6A3392F9496" modified="2012-11-28" version="1">MDRETTPTPASARSERYRGAVVELPPAFCVDYKAPLSIALEKAYEREFDQLPRPIGYLAVPALKQKFERKEVNPSDPIASYMTHFPVSSKSHPYTVITPDTALENLEDFFNQKGTDFALVTDAERRWVLAVATRSDLETFVKRRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKJ7</accession>
    <name>K1VKJ7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKJ7"/>
    <dbReference type="STRING" id="1220162.K1VKJ7"/>
    <dbReference type="eggNOG" id="ENOG502RBH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090088_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKJ7"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29426" checksum="6804D321F0741EA4" modified="2012-11-28" version="1">MSQSSHKAASDEEDGPIEVKDDSKWTEGDFSLISSDGWKLKIWSYHLISASSVLRDAHNCATPGSSMEITFTDTELETREVLDLFLRFATEPDGPNEKSNLGAYTNLVLFLRKYDCPRVLETLSIYLKRELLEGLWPLVDTFVLGSILDNPQLCAAAIDRYSELKRLEAEPDFDVSSIPAPTLDRLPREHIVALSEAIPTHEYSCPNCAHVDHDSLSEAAETFRASLRRLERERKAALEKKRPNNDEQTDTALDSKKQKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKL9</accession>
    <name>K1VKL9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 19">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">A1Q2_00925</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18 19">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="EKD04695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_001935_1_1_1"/>
    <dbReference type="InParanoid" id="K1VKL9"/>
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    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sister chromatid segregation"/>
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        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TOP4c"/>
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        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
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    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
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    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
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        <property type="entry name" value="TOPRIM_C"/>
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        <property type="entry name" value="TOPRIM_TopoII"/>
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    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15 18 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16 18 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 18 19" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="22">
        <location>
            <begin position="579"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="23">
        <location>
            <begin position="815"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1184"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1284"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1227"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1203"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1318"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1333"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1385"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1413"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1446"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1473"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="18">
        <location>
            <position position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00019635"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
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            <dbReference type="PROSITE" id="PS52040"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EKD04695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1525" mass="170156" checksum="DCB374F14A066A37" modified="2012-11-28" version="1">MPTALPQAARGTLTTATTALRRGHLLLSSLSTPRSLQPFTAAPFRPAPHPPHSSISLHHRRLLSGMSDSEGSDFNMVSDGESDGYVEAPTPKKAPAKKAAAAPKAKKAAATKKTPLATKKNLPNDSLSEDDDYNIFTSPARPKVNGAEDDDAPKSAKKKTASEMYQKRPDTYIGSVEPHTQPMWVFDSENKAMVNRTITYVPGFFKIFDEILVNAADNKINDPTMDTIKVNIDRENNSISVWNNGKGIPVEMHSKEGIMIPELIFGNLNYDDDQKKLTGGRNGYGAKLANIYSLEFTVETADKSNMKKYKQVFSQNMGKKTTPKITENKKGEEWTQITFKPDLARFSMTNIDDDTYALLMKRVYDVAGTVKDIKVNLNGERLKVKNFKQYVDMYVAANSAAHTAEGAAVTKPTVVYENAGKRWEVAFALSDGEFNQVSFANSIATTKGGTHVDMIATQLANKLQAFIVKKNKTAKVKPFQIKSHMWIFVNALIENPSFDSQTKETLTLKSSAFGSKCELSEEFIKKVAKSGIVENVLAFAKFKQDQAMKKTDGAKRSRIGGIAKLDDANWAGGRNASQCTLILTEGDSAKSMAVSGVGAIQGRDRFGIFPLRGKLLNVREANHDQIMKNQEIQNIKQILGLKHNHNYTSTDSLRYGHLMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPNFLNEFITPIVKVTKGKQERMFFTMPEYEEWKEANNNGHGWFAKYLKYFNDIQRHRLRFGTLEDEDKTLIDLAFNKKKADDRKEWLRQFKPGTFLQTDDIDEIPISDFVNKELILFSMADNIRSIPSVADGLKPGQRKVIFGCFKKKIKNQIKVQQIVGYILENTAYHHGETSLYSTIVGLAQNFIGSNNVNLLAPHGQFGTRLQGGKDAASARYIHTSVSRITRTIFHPADEPILNNLFEEGLHIEPEYYMPVVPLVLINGADGIGTGWSTSIPNYNPKDVVENIRRMMRGEEPEPMVPWFRGFKGTIERLDKDKFKVSGVAEKIDDKTIEITELPVRKWTQDFKEMIEQMTSGSDTPKVVSVIKDYEENHTDTTVHFRLHMKEEGMKKAEADGFDKFFKLSTTLSTSNMVCFDLEGKIRKYSSPEEILGDFYPKRLEYYALRKQYLADDLNKQFDRLSNQARFVQMIIKKELSVSNKKKAVIVQELRDHDFRPFPKGGPKPVTAGESAPTLEEEEEEEDQGSDADYDYLLGMAIWNLTEEKVKKLLEQRDAKEQELIELLKLTPQDIWSKDLDEFEAEWEACLEEDEAIRRATKPKTAAAVKKAVKARKRAKGEDTDDSEDDFKPTKKVTKPRAPAKPRAQKAATPRVASAAASTNASPAKASAASSTNTSPQKRDSASLSDDEEIKPPPKKATTSRAKTPSASIVELDSDEDEKPVVKKTAAKAKPKPKPKTVDIDDSDDDNKPKAATKKAPAKAPTKAAAKKAAPVHDSDSDAEVLPKPKGKAAAKGKKKDASDFEDSDEDVPPPPRTTARRGRAAAVKKPTYVDLSDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKV4</accession>
    <name>K1VKV4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maintenance of ploidy protein mob2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKV4"/>
    <dbReference type="FunCoup" id="K1VKV4">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKV4"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_2_0_1"/>
    <dbReference type="InParanoid" id="K1VKV4"/>
    <dbReference type="OMA" id="CNHSSER"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="287" mass="31837" checksum="1BDF818EB04C290E" modified="2012-11-28" version="1">MSGFLNSIGSLPAQPDKAAAVSHGPSTFRAAPAIAASRSGHDTGRRLRAPKRSPVLTMPGGQQYDAPLASPGAEFSGQPASPTGPKPLFLCQPFVKAALVKGSFKTIVAPPKYVDVNEWVAINLFDFYHNLNHFYSALTEFCTIHNCPTMSAGPTLNFLWPDQNQRLVSLPAPTYIDFVMSWLQKLLEDENVFPTKSGRDFPTSFAYTAKHIYKHLFRVFAHLYHAHFEQVVHLSIEAHFNSLFAHFLAFGKEFDLLVMKDLMTPQGMGQGVAELAERWREMGILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL76</accession>
    <name>K1VL76_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL76"/>
    <dbReference type="STRING" id="1220162.K1VL76"/>
    <dbReference type="HOGENOM" id="CLU_334386_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL76"/>
    <dbReference type="OMA" id="TSEIANW"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="854" mass="92496" checksum="02C7F073635CBB78" modified="2012-11-28" version="1">MPTPPTAPTPAGRRDHQHPFDLETPFGKIQPVFEGFSLATPGWMHEDSTLPSMDAEPSVRRSPRRQSRIHDAEQPQPIVQPTPRRSPRRSAWIPDDTEVEQPTPRRSARRRTTVARLGFPSMGDSTKESLAASMARSRSISAGPSEGSPSKPAKMRAEGSTEPEMEMEPRERETRTPAVAARAIRQTRASTSTPSSSNDLYERRLLDSARRRTLLPLPGHDWAEEGLASSTPAPVRSRRQSFRLSPEHELVSPLPLATTAAPELAQSTVTPPIESAPTEPPRPQTPQPPPSRTAPQQSTPENKFVLPPCVSTRKKRRMASPDKPLFRTSIESAPEAPAESSKPAQPKFLGELSQVLHARASTPDDAAALVPKPASRLSSSSSKEGSHSSSTSGKSKVKRTVIKVGAGGKIRTSAHAAELVAEQEESLRVEASMSLDRSRDKSIDKTSEIANWSRNVGSILPTDLGLRRSESLQSSSSRLTRHGNSSESREGTPVSLASLSSLSSRDSLPARPQNPTPRTASPHRDHFDLSTSLPPRPSAPALSDSSFSTSAPKRPSNPTPTHAHTIRASESPAPTKTKLSKSASDAEPAKPKQPLTSSIDRPIKRFPARKAVPAPVPAKPARSLPQPVAAAPKVKALARKRQSSDPPRPQTFPARVRNGPPVLTPAKKTSKLAPKTRLPVPAPTAPTAPDSTEPSAKRAKVTPVEPEEPAGSTTPPHVVEALATPRRHSVTVRRTPRGTTPRRTPAPISDWPELGLNKEQTAFTFEHRLRQAAEESPAVDPPSISYPSYPSYPAQSARRESYATDTDSDDDEMEIEEEEEEGADLLNPMEEFDIIRPHGQELSAVLEVTEVQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLD9</accession>
    <name>K1VLD9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-CoA hydratase/isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLD9"/>
    <dbReference type="STRING" id="1220162.K1VLD9"/>
    <dbReference type="eggNOG" id="ENOG502S297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_3_1_1"/>
    <dbReference type="InParanoid" id="K1VLD9"/>
    <dbReference type="OMA" id="EMGIVHS"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31290" checksum="CD92ED9034FC1676" modified="2012-11-28" version="1">MTTEQRYWKLDKFGPTNWVLTLSNPPDNRLPPNVIVDLLQRLDEVEAAWRSAWDKAPDDKKPGGSVVFASDSKKFWSNGLDPTILTSPAFMQHVLYPLQSRVMTFPLITIAAINGHCFAGGMLLALCCDYRLMTTGRGWMSMNEVSHPGKLSPALSGADGQLLIGEPIPSDVSNVLKARISPTYWTKVILAHRWTAQEALAAGIIDETVDNDGPNAGNLLKRAKEMALAKGPVVHSGVWGAIKAGTSVPVTDKPIRQRIAYRPEEERIMFKKKLATAKFRASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLM1</accession>
    <name>K1VLM1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear membrane protein,putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLM1"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040960_1_1_1"/>
    <dbReference type="InParanoid" id="K1VLM1"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="213"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="45611" checksum="EAC91C2DB97B46E2" modified="2012-11-28" version="1">MFRRDTSGPMDVDSMDPMARLAEFAEPPRKRPHADLSAPQSSGSSSFRFGPNTPFLFHATAPMPPTRKWEPYDPQRWAGTDFGMGSATSGVVDVDMDGEAAPAAPAAPAGVSGVGETAGAHSEFAGSVNGGGGEEGPASPKPKPKGKPKQRKKVTVEDDEDGEERHIATGAITRVRRRRKEWARRGAGDEVGPTYNLHLGPNGTQHRDIPGILLGQFIFNLSLVLFFLYLALQFIIAIRRDVSERIDEYSVEILQEIAQCTQAYVTNRCEPATRVPAMEQACSAWETCMNRDPKVVGRARVGAETFADIINSFVDSISLKTMLFSTLMIGLLVVLTNSALFNLRAKQELVHQRELHQHKLAQVGMPQYPYYHLPPGAQQYGGQPGLPPPASPSGQPLGLAPPPGQQPEEPKKSKWLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM53</accession>
    <name>K1VM53_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM53"/>
    <dbReference type="HOGENOM" id="CLU_1595724_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM53"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="167" mass="16812" checksum="C2A59F880EC607C6" modified="2012-11-28" version="1">MIHSNIAVLSGRDLSARDRWHPDVPPCVKDCCHKYGGKYQDQDNNITCGWDKAPPGAMDGYATCRDACWPGPHKRQATDHASSAVSAKASASAGHSASHKANGGGSVGNAPSTSAAQTKPQASGSHSASGSAKPSASGKKKSAAGKTASMNVGALLLLSAAVAALTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN14</accession>
    <name>K1VN14_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN14"/>
    <dbReference type="STRING" id="1220162.K1VN14"/>
    <dbReference type="eggNOG" id="KOG1324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_2_1_1"/>
    <dbReference type="InParanoid" id="K1VN14"/>
    <dbReference type="OMA" id="QYEFQMW"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="194" mass="21497" checksum="58951DCAC02BF7A2" modified="2012-11-28" version="1">MTNPAKRSLTAIVAATVDGGIGRDGGLPWRLPGEMKYFARVTTGEASMMAGKRNAVLMGRKTWDGIPTKFRPLKERHNLVISRAGVDVSGEQSTSAHGSLVDAIDSIPADTHRAFLIGGAQLYNQALPAHVDRVLLTRVLGHIPCDVFLDEFTASPEWRQATHQELCDWVGWDVPEGEVEEKGIQYRYEMWVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP33</accession>
    <name>K1VP33_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP33"/>
    <dbReference type="HOGENOM" id="CLU_093257_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP33"/>
    <dbReference type="OMA" id="TIPASCK"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854273" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="24277" checksum="270FFEB411F01AE6" modified="2012-11-28" version="1">MLQSLVLVSALALTASAQSFPGLGTIPASCKSQCAEVSSFANSCASMDETCLEKVCANAGKFKSCLDCAKMSSIYEQFESSCSMLGYDVAGGSSSGSSGSSDSSGSSGSSGSSGSSDSSGSYGSNSGSDSDVISDVGTTRKPTIGAIMPTLTTPDLSTVTGSGLAFPAPEESASAGSGGAGAGGLSGSNADNGGAGAGSAGTGSTGSGTGSGSAAGPNAGSSGSPGITVDEASKQMGNSGAASLGASAFAVVAGIAAAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPG4</accession>
    <name>K1VPG4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPG4"/>
    <dbReference type="STRING" id="1220162.K1VPG4"/>
    <dbReference type="HOGENOM" id="CLU_2308030_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPG4"/>
    <dbReference type="OrthoDB" id="4505683at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852317" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10172" checksum="0CB0849F434DA7F8" modified="2012-11-28" version="1">MKVIALALTLFAAAGSVSAQVDASTVDPCLKGCVIQAAKEIGCWNEGDIPGSIKCGCGDKRGEATSHGVACLQGKCPEQIGGAWGLFDKMCKEGVTGNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPT7</accession>
    <name>K1VPT7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPT7"/>
    <dbReference type="FunCoup" id="K1VPT7">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPT7"/>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_1_0_1"/>
    <dbReference type="InParanoid" id="K1VPT7"/>
    <dbReference type="OMA" id="RALPECW"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="352" mass="39229" checksum="CB8C37AF794CD5C2" modified="2012-11-28" version="1">MADSPVRAVKDIQVWGHRGASAFLPENTLASFRAAIKEGADAIESDVHVTSDGVILMFHDPTLDRTTNGSGTIKSQPNVRTTKEPVQPVPRFDQLIDLIMEPENKHVKLNVSMRMDRGGLTADRLQDPKRPRGSLRESPAVPWSVDKYENWEQELAPRIILGLWHPLFIRPAYKYLPSCTRYHIGISPSIARQYFWDACAGFSINFSMLVGSEGQKFIADCRAAGKEVCVWTVNDPNEMRTAMTWGVQAILTDKVGLLTELKKEVVEDPSKVDIPGLAAYWFPWSHWRYYAFTHVCGHYLARAYLRSHGSFATDHFVEHTSAPNSPASTPPGTPLECATESSSPALARAHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ93</accession>
    <name>K1VQ93_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_04143</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ93"/>
    <dbReference type="STRING" id="1220162.K1VQ93"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="InParanoid" id="K1VQ93"/>
    <dbReference type="OMA" id="AHAQYMV"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="292"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="517"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD01582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="700" mass="77778" checksum="783453134ED4907A" modified="2012-11-28" version="1">MPRQPPPPEWVQKLQPSSPQGADLLAAERAGSGVNVDRLAELLHTREVLDKRAAIEKIVAAEPVFDKTELLSMGRVERMQRSLARGKKLKQLQKQHNWSFEDYKVANTIAGEPTTYGLHDSMWLVTLREQGTPEQHKLFLEPALANKYIGCYAQTELGHGSNVRGLETTATWDPTDKTFVLNSPYLTASKWWIGSLGKVANHAIVMAQLFVNGKNHGPHPFVLQIRDLKTHEPLPNIYVGDQGPKFGYNSMDNGFMLLNKVKIPHINMLARFNVVDPETSEYRRVGSPSLIYGTLTWVRSTIVLEAGAALARGVTVATRYCAVRRQFQDRDAEEAGLKTGETAVLNYKMVQQRLLPLLAATYALHFTGRGMMAMYNANQEAMNKNLAAGAKDARGAGPEELNPGAELLADLHATSCGLKALGSTIAVEGLEVTRRACGGHGFSSYSGIGPWYADYLPTATWEGDNYMLTQQVARYLLKTARQVIDGVAPKNETAEILQFYISRKDTGVANDVLNNDADIVRAFAWRTAFLTLEALKLRDKEKKSWNSLLVAFWRLSTAHSQYLVVRNFYDAVFKDPARLAGNVGDVTADVLQDLFRLFALNTIENHAAEFVTSGAITNNQLTLARVKGVSNLLDRIRPHAVKLVDAWSFSDFLLASSLGRYDGKVYQDLFERARNNPVNELIFDPYPDSDVLIKRTGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRD2</accession>
    <name>K1VRD2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRD2"/>
    <dbReference type="HOGENOM" id="CLU_973824_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRD2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="31427" checksum="CC2ECABCF5BA9352" modified="2012-11-28" version="1">MATSNGSLATTSLFPLRRQSPTPWTAGVATTGIVAPGSHSRRPAARTAYDHDSALNARPTTKRQDRRGETLTLPKPPHGEHLRSAWGEPHPLTGLPTCCGGDVKEIKHQHQANVKLTSSQHQVTSRHFKKIKRRLKTQYRRMEENMATPSSPLPTGLQVAAPTVLAPSVRPQVAPDGGDSKWSSRCPKWCRLACKSGPQVAPAIKTSRLQDLKTATRQDFKTSTSRHQPQDSTPQGVPHSIGRRDREGLNLKPSRSASQHREAGQGGSQPQAIKSWQARFDLQHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRN1</accession>
    <name>K1VRN1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRN1"/>
    <dbReference type="HOGENOM" id="CLU_2039713_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRN1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="121" mass="13085" checksum="D0DD52ED8C497D51" modified="2012-11-28" version="1">MEARPNSQETAPLLGNSPRSPSASFRPPLLRHRTISSLSLSSTQQTAEEQTRSSFHGLLILLGLIVISGIVIVAWNRYSGRTGGLSLPNSEAPVEPLECSLPPETVGEGELPEFVPYPYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRR5</accession>
    <name>K1VRR5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRR5"/>
    <dbReference type="STRING" id="1220162.K1VRR5"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052539_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRR5"/>
    <dbReference type="OMA" id="WRPKIGQ"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="6">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="356" mass="39293" checksum="23202E82443CDE2D" modified="2012-11-28" version="1">MSNAEASSSKHKDRRSKKDKKEKKEKRKHKHAVEVAPVTGGAEGPFEHRVQRMRLSVPPKFSADWMEGVRESLDGMLMRYVGQMGGVLLAHWDHQFCDDSIKLINECPFGVTEVTFRSIVWAPRLGQVLQGTHSLSSPSHLSLLFGKTFNVSIPLQHIPQDKYEFEHTGEAAESDSEDEDEPLGAVEEVGRWKVKSTGQTLGASGERVPFTVTNNMLSITGSLLDDPSNPPALPAVSRRTPSLSPELPEPPAKRPYRPRASVGKPAAATPSKSQHTTFDEEPAAAAESAEAEPEVDTSKMNPRELKKYRKEQEKAKRDARKARKEGAAAEAAEAETGTKRKADEEDGGERKKRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS13</accession>
    <name>K1VS13_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS13"/>
    <dbReference type="HOGENOM" id="CLU_1972023_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS13"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="127" mass="13186" checksum="53C40F05ED824BA5" modified="2012-11-28" version="1">MMINQNNEKSIAKLSQGGVPSYAGLTGNALLAAVVATGTVGFALFGYGECLFLYATGQQSAIPRIVAAPAEFSASIQAFSPLPHCTSIDPGPLTIDSFADATIAFSEFSGLHLVLSGNRHSRRLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS29</accession>
    <name>K1VS29_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cleavage and polyadenylation specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VS29">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS29"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002414_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS29"/>
    <dbReference type="OMA" id="GQVTQGW"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="161"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="525"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1339" mass="146701" checksum="B2969FDFECA36932" modified="2012-11-28" version="1">MHAYHSTLLPSSAIHHSLYLAHFTPSTIYPLPKPHAALEVPDVKVVGNLVVAGGQDLRVFEIREESTPLPDDESAVPKQEDMDVGDSFFDSAPIERAPVRYKTTRRLHLLTRHTLHGVVTGLAGLRTIDSSVDGLDRLLVSFEHAKMINGNFQGYVPMLRSDPLSRLAILTLPEDALAVLPIVQEQSELDAMQDSVSSPEIKNIKDFLFLPGFHSPTIALLFAPMNTWAGRYKSVKDTFRLEIRTIDTSAGGTYPLITSVTGLPSDSQYLVACPSEVGGVVVVTASGIIHIDQSGRLVSTSVNGWWNYTTNMKSDSSYESQKLALDNSHAQFVTENDMLLVLETGEVHQIRFEMDGRAVGAIKVDEQSSTVPPPSTLVPAGSDGIFVGSVEGDSLLAMVEKARDQSAQEEPETKQQEMDVDDWDEEVATGPVTVSVKAQDVLSGIGRIADMEFGIAVTDLGTRTYPQLVCIGGGSQGSTMNVFRRGIPITKRRLFEQLRTAVATWFLPVERANAPKFKDIPESEQSTIAIAATQEGSTQIFALSTRKVQERIAEFPEPAIATGTWLRRTRIVLVLPSQVLLLDSNANPVGTICEMSDAPPIVAASIADPYVLIRRADGSVSVFVGDTVEGKWSEAPMPEGLALPVCQAAEVFTDTTGIYRTFEATQGVKEEPVKPVPTKQGQKAKIHLTGEQLKRLQDSKPAISADVATTESAFNAARGTQWIALLAQSGELQIRSLPDFDLVLQSNGVYDSEPSFTDDQTGELPELEEGDEVSQMLFCPIGTRTLRPHVIVLHRSGRLNIYEAQPRFTVDARDQSRRSLAVRFRKVHTQLLSVTPSSTVKPAAIPFTDIEGLTGAFITGERPHWIISSDSHPIRAFGLKQAAYAFCKTTHQGGHGEYFLRIEDGSFICYMPPTLNTDFAMPCDRYKMERTYTHVAFDPPSCHYVAAAAMSVPFQAYDEEGEILLGPEGPDLLPPKNERSSIELFSAGSEPFRVLDGYDFDQNEEVLCVESVTLESSSSPTGFRDFIAVGTGKNFGEDRATSGAVYVFEVVEVVGTKPGVSNWRLKYRCKDPTRNPVSAIANINGYIVHSNGPKILAKGLDYDDRLMGLAFLDVSMYVTSIRVFKNLILVGDFVKSLIFASLQENPYKFVTIGRDLADLSLTAADFLVHEGQVTFITNDQHGNMRLVDFDPANPDSLNGEKLLTQTEFGTGCPVTASCMIARRKTAEEEFAPQSQLIYATADGAITSVVAVKEARFKRLQLVQDQLVRNAQHVAGLNPRAFRTVRNDLVPRPLARGVLDGGLLAHFALQPLRRQREMMRQIGTDAVTVGSDLYTLGGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTC1</accession>
    <name>K1VTC1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_02892</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTC1"/>
    <dbReference type="FunCoup" id="K1VTC1">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTC1"/>
    <dbReference type="eggNOG" id="KOG0711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="InParanoid" id="K1VTC1"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD02817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="354" mass="40336" checksum="E27DEBF5AFF75819" modified="2012-11-28" version="1">MADKAAAKAAARAKFEGVFDTIADELLAYLKGEGMPADAIEWYKKNLYHNVPGGKLNRGLSVVDTLEILKGSALTDDEYFQAALLGWCIELGFFLVSDDLMDASITRRGQPCWYRMPGIGNIAINDSFMLEAAIYYLLKKHFRQQPYYVDLLELFLETTFQTELGQLIDLITAPEDDVDLSKFSLEKHHLIVVYKTAYYSFYLPVALAMRVHGIKDKAAYKAALDILLPMGEYFQVQDDYLDAYAPPEVLGKIGTDILDNKCSWNVNTALKHATPEQRQILDKYYGNKKDKEAEAEVKKIFSSDNVDIPGRFEKYEAESYDKLNKLIDQIDEDKTGLKKQVFTSFLEKVYKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTX7</accession>
    <name>K1VTX7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VTX7">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTX7"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002330_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTX7"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
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        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
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        <property type="term" value="P:protein import into nucleus"/>
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        <property type="term" value="P:telomere tethering at nuclear periphery"/>
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        <property type="entry name" value="Nucleoporin SONB, putative"/>
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        <property type="entry name" value="Nup98_C"/>
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        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
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        <property type="match status" value="4"/>
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    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <begin position="930"/>
            <end position="1072"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51434"/>
        </source>
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    <sequence length="1926" mass="203784" checksum="01CA6A7F6DCF05D2" modified="2012-11-28" version="1">MFGSTWGQNNQQKPGGLFGSGTSGGFGQSSGELLGRLNACADNSGGFGQQQNTGGFGQQQQQQNTGGGLFGSTSNQTSGFGSGGFGQQNNQQTNSFGARPTFGATGSSPFGGAATNTGGGLFGSNNNTSTFGSNTGATSSFGNNNASSGGLFGSKPATGFGSTTSSGGLFGQPQTSTFGSTQNAAGPSNQVHNYTPGPLPPCPQTGTAAPPYQPTWQRDPSGPLNKDPLPPHLFHVITAMDAYKGGSFEELRMLDYQQNRKEPTAQPAAATGGFGQTTSTTGGFGSTGSTFGQPAQQNTGFGAKPAGGLFGSTSGTTSGFGNTSGGFGSTSGGFGQQNNTGSVFGQQQNANTGGFGQAANTNTGGGLFGQQQNNTSSGGLFGSANNNTTSGFGQNNQQQGTTTGFGGFGAKPAFGSTSTTSTGFGQTNNATGFGQTNTGSTGFGFGQQNQQQQQQPQQSTGGLFGSTTNNAFGQNNAQQNNTLGGGTSLFGQNNQQQTNTTGGLFGNTANKPAGGLFGSTPAATTGTTGGFGGFGQNNTTTTTQPATGGLFGNNAATTTGTTGGGLFGNTTNTTTTQPAATGGLFGNTTNTASTGGGLFGAKPATTTGGLFGSTTTTQPATTGTGFGGFGQQQNNATTGGGLFGNTAANNQAQAKPAGSLFGGGGSSLFGAQNNQQTTQPAAGGSLFGGLNQSQPAATGGLFGSTASTTQPAAGQTGGLFGSTLGQSTAQQPSLTASVDQNPYGKNELFAYSGQKLEVGSTNKKPALPPLTASSYRVTPSKGRVVKLRGFASPLNASQSSGRASSPSLASPSRSVIGSPAPSDRYNGLTDAALSPNAFIPRPNVKKITVTPKANAVNSEDPLESVLGKSQLRGSVNGNGTPATPDQGSKSPTLSINNGRALTGDDTPTRRSQPIAQESIRAVTAERPLKRGDYWCRPKLEKLRSLSHQELSKLENFTVGRKGYGEVTFLQPVDLTDLPSLQDLFGKTVIVEDLELTVYPDDSNKPPRGQGLNVPAQISLENCFARDKATRQPITDPNDPRYRRQIKRVKAVQGTEFVDFSDDGIWTFTVEHFSRYGLADSDEESDEGMNDSPSTGKGKQLSPDSTIEGETESEEDDFLPPTKSMHDRDVDMDHDSGLEETGDSYDEADEEEDDESFVSERRWENPVTNNLDSPGIRRVRLMQSNFFANQEVAAPAVSAAEAQRTRALEAARALQRGRAEAGFGEAEEDMNELDDRAVKRASFGELASPPPRQPRKYAKVPLAESSVNGNEGVRPDTGLALGRSFRCSWGPNGELVHFGKICAPKAEYKSPSDATVFVQQVDLLADSPEIERPKADRLLSLLLDNSQIEQVDGTPMAMTSTEIRFKEFARLFDEGDRSHEATIWRLGKALFDEIDLRLPPDTPDDVRERVFQVRRKLALSKWLEDAVAPAVDGDLAAAGDNRPAKLFSLLTGNQTDRAVQSALDGKDMRLATLVSQAGGPEVFRSEVLRQLDDWTKFKANSVIGYDYRRLYALLAGITDVSKGDSSRGADAAPDVLVAEGLDWKRAFGLYLWHGRPFEETIGQVFGAYTHALDDAHPPAKPIPPYLEKPDGEREWNMATKPTDVLYNLIRMFVDLTVPLEEVLSARGCSPSPTDLRLPWHLYLLLTQALEARDFSDREEPNAEGIAFSASANELTRSYAAQLEEEGQWTWAAFVLLHLELPEARRNAVRELLFRHPNPNNSERMFLVNTLRIPPAWLHEVKAAEFATENDPYREYFELIRAGLADRAQRLLITKLAPEAILRDSQSLLRRLCEALEPLHPTGWEYGGKLFLDYLNIINDTKPLLASVLRAGLHPDPVEDAELNRLCKSVPRVIQLLPALFPNKDDVQQVASLSEMLSNLQNLGAVLHMNNRIERPPISDLLVDKDRLHLLQGAATESFERSLSAIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU15</accession>
    <name>K1VU15_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU15"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002116_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU15"/>
    <dbReference type="OMA" id="EEVWERD"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7783"/>
    </dbReference>
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        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="824"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="958"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1291" mass="141723" checksum="1F66310A2065B28E" modified="2012-11-28" version="1">MYLSFKAGEVIRVHGRDPSGWWDGEVAFEEDGIRKSRRGWFPSNYVRELEWDEVSHKTLRVADEQQLLRRPERPAAEPAGILRSRRGSVASHESPTTSHQSHSSSSRLTTPLLDGSLPPALQALLQPVMQTLSLLHSSVSADRRRHITPSAAQVIAAIRQTLLRMDCLSKDSATLAAHPALGQQRRDVLAELSKLVSAAKQAGSEETRPDDDASLEATSRAADRVFNSIRGFLQCAGEMGVSVLPLATDGDRQGSDPAGPSSSRRLSRARAPSGSGSRGSRIPASESMRLKSASVSDLRGSARRQASNSSPPPPMPNASMSAGPPSASRFSGRSPSTTSGRSSPGRARRTSRVRHHRSQSFDFEQDNTETDIESASQSTHGTHSTHQTHVTPMVNPAARATEGEALYKQYSTGRAVHEAITAAEDALLSIIASFIGHIHSHHFDSHPSTHAYLIELTRETVDRVRDLLTIVEVAGQQASLLGMHQREIPTLRSARESLYEAAEQLVESAESVSRTFNQHLGEEAYEAEKAQLLVRTTKTLKAGTECSEVVKRIVPEDNTEPDFDSPDLNMAGVGYSPRKGYAAIGLGIRSGPGSLQSLTRRATSLGQLHRRYNHDGAGRVSMPPAKGDEDEEGEEEIVEDASSSDEEADESTETASTGRRGMRPISHPSQPAVGHVQRRSMDSGHPRSRSSNIRSSQVLGDRRSMDTTYTGELKTEESETTAISHRDSVHASVRTSTTSHVASSLLQSASSTGLSEITTTPSLSESGTTQVDSPKDADGKAVTRHTPPTPRTGQSIDGNDPAGGDVRFWVVSHDYDPVEVAYNSDGILVGGTLRVLVEKLTPHDGPTDHNFMSTFWYTFRLFSNPTEFLNALIARYDLKPPPALQGVGHEQYHMWVERKLKPVRIRVCNVLKVWLDQHWRPDSDNAVLDTMEEFFLKRANDQVTPSLAAPGGRVAELVRKRKEPSATSSDSASNAPGTKQTSFDRIRNSAFPGRFTTPAVSTMPNSNISKALMNTLMKNPAPTAVSLTDFDTLELARQFCIMESKLFQAIAPEDLLMSGRKQVPALKALSTVSNQIIGWVTDGILNEQDAKHRAALLKFYIKLADKCLSLNNFSTMFAVLGGLNSATILRLKKTWDALNVKYRNVMEKLRAVIDHTKNHRAYREALRAATAKDEPVLPFLGLILTDITFTQEGNPNTRPSTLSPELQLINTDKYAKLGRIANEFKNYQRSFEYREIECVQTFLQRALTERGSGSLDALYRKSLLLEPRQNSERLNNMVEKPGWLGARLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU28</accession>
    <name>K1VU28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU28"/>
    <dbReference type="FunCoup" id="K1VU28">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU28"/>
    <dbReference type="eggNOG" id="ENOG502QS8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010934_1_1_1"/>
    <dbReference type="InParanoid" id="K1VU28"/>
    <dbReference type="OMA" id="WDRRQPN"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="4">
        <location>
            <begin position="101"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="4">
        <location>
            <begin position="441"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="613" mass="63746" checksum="B836832541908746" modified="2012-11-28" version="1">MRSDDEEEHDFEEDEEDDDAALSPCPPAPCPPCQHQHIPTPSLPPGSAPPSADAPPEAEKDTTTSVDIIAPQLARRSLFVPQATRQGISIEAIVGIPIPSPDGYVRAYDFWPSVNGAQIMTAQQRGVVGLGEGVNKAGVGRGWWAVEVPEAQVNASGSGTATGNGGAAAGTTGSKKQEPVFSLACDPDGLWSAAGTQSGDINLYSLRHSPGTQITSLRGHNNVVSCLQLVDDTSLLSGSWDGVVRTTRTYPGHGAQISAVSVRPPVVAAPAPISVNVGEDFFKKDREANGTNGTTDGANGGDGDVEMKDASDKPVEPPAEPAAADGDDNKSNASYDPLFDDDAEGEEDVTMDPAPGLGLALPGAKPAASPALPTLSTPTPAPPSQSSQTGPALPGQPSQNQPSTLSAPGLFSAASTRAAATTTSNAKATPSLSPATYHSMSPDILLTSSMDGQITLIDRRSPSLVGRLGGSKAPPWCMSAVWQGEQVLAGRRNGTIDIWDVRRASPSAPSLIKTLKTPAESGPISCLVAFPDGKHVASASNDNIRLWNTLEYFDEQQETKRKGVPFRIIAGHHGGIISAMNLDPTGNFLVTASGDRGWQGESTKVVLVHEVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUM0</accession>
    <name>K1VUM0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000262">
        <property type="protein sequence ID" value="EKD03212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUM0"/>
    <dbReference type="STRING" id="1220162.K1VUM0"/>
    <dbReference type="eggNOG" id="ENOG502S8YE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_804572_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUM0"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="345" mass="37835" checksum="69CD1993FA70CC52" modified="2012-11-28" version="1">MPAVHRYKFPVRPGNTERQPTSVRGAYLQNLVDCVHICILRGLYDKARRAWAILVRCPDIDWKQRWGWGLFLLTRDAEGRQPTTEGGESLSRRGQDSATDYLTKLRLQKPAVLEELAQHLVYTGRYEPALNELETFWLAQPESKRREARGGPSSDAGLETSRRRGSSSSSSDIEDSEPSAVHPKLTTDEPPDESKLQKARYHFGNALQVDPSHTVAKGFIDLERCPVPGVNRADSPPDQDTARSFGAMSLDAVDDLGSGLNLGRAGMGLGNLARLTGLSELTSTSRNASVADLADVRGEESDDSRDSMDSLDLVSDGGDESQTSDTEARGTSPDSQGMDVDMDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV29</accession>
    <name>K1VV29_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV29"/>
    <dbReference type="HOGENOM" id="CLU_1349746_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV29"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="203" mass="22777" checksum="CD0440D9184AD887" modified="2012-11-28" version="1">MTLAQPQPFRLTIRSKWTVDMVEKLLAIADASAEHATVSVLGRPVELRETREVFYALPEAEVDGMAQPWSFTMIDMRTGIGRLFVIADDPSDHRYSLRPPRRTRAQGHSNAFEVTLLPSELGALPPPMAICAVLIWLTRGHAGTRLAAIDRLRINEALVVPELNALLRGEEWAGKSVYIEGVPKRALNTDTNRRCSKRLRTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVF7</accession>
    <name>K1VVF7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endo-beta-N-acetylglucosaminidase EndoS/F2-like TIM-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVF7"/>
    <dbReference type="eggNOG" id="ENOG502SP93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055072_1_0_1"/>
    <dbReference type="InParanoid" id="K1VVF7"/>
    <dbReference type="OMA" id="MAGYFRS"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057016">
        <property type="entry name" value="EndoS_F2-like_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23916">
        <property type="entry name" value="TIM-barrel_EndoS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852493" description="Endo-beta-N-acetylglucosaminidase EndoS/F2-like TIM-barrel domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-N-acetylglucosaminidase EndoS/F2-like TIM-barrel" evidence="5">
        <location>
            <begin position="45"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="34070" checksum="4C7005BFA30CFED1" modified="2012-11-28" version="1">MLVSLLPALALLASPALGAPTPRGSSNSSGPVGPQSSCGTEIYGAYWRTWNDAATGFQGKEARMDSLPKGTDVALVFEAEGAEDTPYYSVLRDEYVPKLHAQGTLLARSIGTEGLRAIQAPADGNYDKIAQDLIAKFVTPWGLDGLDFDIEERIDGEEAEHFSKIFHALSKYLGPKGKEGTLLIYDTNQDADRFFPLIADVVSFVFLQAYGRDVGRLQSTWDTFSPYIDSCRFVPGFSFYEEQGTNGWHDTERPLNTSRALAYAEWQPEGGKKGGVFGYAADRDWKADGDDTISAPTYEVAHAIFHVQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVP2</accession>
    <name>K1VVP2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVP2"/>
    <dbReference type="STRING" id="1220162.K1VVP2"/>
    <dbReference type="eggNOG" id="KOG3172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2322007_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVP2"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="99" mass="10848" checksum="7285B9B0E8C84E56" modified="2012-11-28" version="1">MALKDITVTARDGRVSQLEQVYIRGSMEWASCIEIRAIDTLRWARRVRLETQIKPSRLLSFRISSPFSSRCLVGWAGAGSSAPSPPPVASPGEAMPQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVT0</accession>
    <name>K1VVT0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000217">
        <property type="protein sequence ID" value="EKD04646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVT0"/>
    <dbReference type="HOGENOM" id="CLU_2575558_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVT0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="81" mass="8545" checksum="02C6CF5BAAE815E6" modified="2012-11-28" version="1">MSTLDALVAEARVSYVASDPLDLVKAAPSLGEEHLAELGAVLGRISALLATMPDPAGETKRRRELRDIFECGARNVPVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWS4</accession>
    <name>K1VWS4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWS4"/>
    <dbReference type="HOGENOM" id="CLU_2544219_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWS4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="83" mass="9953" checksum="EC67BC638E2F6335" modified="2012-11-28" version="1">MEQSRLLRSQIDDLKMVARELRDIVRTKEQTHVAAIVELEIQRRDNEALRLELENQRRENGALRLELERIQRAAKTDNVEREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX34</accession>
    <name>K1VX34_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX34"/>
    <dbReference type="STRING" id="1220162.K1VX34"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368888_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX34"/>
    <dbReference type="OMA" id="HEMIGSK"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="205"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="755" mass="81933" checksum="F66E05739A1948F6" modified="2012-11-28" version="1">MLQGSTPRRVSSPAANFFAQINGTASSAPSVASDDTNDVASAASEDVNAQHQYAGLGPAFANAHVRRTQSLRSPMRPHDHAGLSSFATASNNLSSQHDSPSSSHYTPPAAASHPLFSHHAIPLSHRQSFSTPQHAPITRTFSPAMTVMSDPGPNDIPEVVVPSPPSSVASGPFSPASAFLSSFSSRGSVSGDVAPDAQGARVLNYTLGKILGRGGFSTVRQAIHVDTGDVLACKIVKRDDLSDMSGSLERFEDEVRIWKDLPHHPALLPLLEMHRTSFATFLLMPFLPGGSLLEVIRREGHGEKTARKWFPGVVAAVAALHEGFEGFEGHMMHGDLKLDNFIVDSHGVVRLGDFGMAQKIEKTDPSSRGSTTPRHLGVTPTHRRMASRSPSRRRETVAASLVNEEGTQVCPSASLPYAPPELLLPPPAPPALSRDVWAVGVILYALLAGKLPFVDAFDPRLQMKILRGQFDEPDGLGHEWCEALHNTMHRYPERRWTIGQVRASDAVTGWREVKSRSRSRSRARGNVHPAHIRGTSHSGSVLDSPIDIWDRGRARGMHLGGDRSRSQSGNRSRQSSRPGRDPNHPRTREASRTRDPQPHDFVREVPGSGGRTGLARTPDEKVLMDLDAMHITRGRSRGRNAPGTSSSSPASQRNSLIMPDMTEISPTGRGASTPRRPHSMHEAGTPENRARSKTRFDPGTQSRGSRKGSPAEPHPPTYGSELYLVEEEERGRRGRSPATRGRLAANRSKSRGRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXR7</accession>
    <name>K1VXR7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellulase like glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXR7"/>
    <dbReference type="STRING" id="1220162.K1VXR7"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="InParanoid" id="K1VXR7"/>
    <dbReference type="OMA" id="AACRYFA"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="654"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="809" mass="91083" checksum="2DEAEAF2865EF475" modified="2012-11-28" version="1">MVPPPKVSPVTGRQVPPYYLHASSVHFQDTQGRSVLLRGVNLSGSAKNPVKTPSWSQNGFWEDAEAATTDWIGSTLDLEDGSADIHLARLRAWGFNMLRFCFTWEALEPKPGKYDYEYMKYVVKCLYKIKEYGFRVYMDPHQDVWSRFSGGSGAPIWTIYACGVDPHNITPTYSALVHSDYPSREDPHPEELPCMIWSSNYYRAFGHLVWTLFFAGKTFAPKCIIDGKNIQDWLNDHYCDAVMELGKVIGEAPGLLDETVIGWDSINEPSEGLIGIENLNETPKNQTVFLGPVPTPFENMQLANGQVVEVPNYKFGPLGPAKDGTVVLDPKGKRLWLTPEADAERGAGKWGFVRGPEWQVGECIWAMHNVWDPARNKLLNPGYFHTLPEDPRHKVEFVHDFWRLHWMSYATAVRTWHPEAVHFMNTTVFKPLPELPESFLQHRACASPHYYDGLTLMTRHWGWFNADALGVMRGKYWSVIQALRIGEQNIRKCIQEQLGQLKADTTESLGRSYPTLIGEIGCPYDMDGKAAYGYANNGKGKGDYSQQQRAWDASVNACDGPNALNYTLWCYVPRNSHQWGDNWNGEDLSLWSQDDTRAIEDNGAGYDSFVSGGSRASSVTLTSRRPSPKGIELGTEVTAKLLLDGSRAVGAFCRPYPVATVGYPEDISFDINSTLCRIKVRVAPTDMPGVTQIYVPFVHYASDLEWRLDEAGRPTGASRSSSQQSLLEADPSSKTGRSTGNLELDIDVRASIGSWTTEGQYLYWTYDVPRTETTYTIEIRRNGGPLRVNYNAKRDQGLWADIKEYFGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY53</accession>
    <name>K1VY53_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY53"/>
    <dbReference type="FunCoup" id="K1VY53">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VY53"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378122_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY53"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="532"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="681" mass="74025" checksum="243450F10B02DEDD" modified="2012-11-28" version="1">MELYIPPPTHYLPRMVVPPRPVVPTVPVVPCPPLPEELIAPEGTYHLAKGWFPDVEVPGPLPTEQRPQQMPLASAALIGAGGFSMGTPAYMPLPPLASPNIFAVSSGSTLVNGQWQPGHPTKMSFADVWFPSRETGKESSFGALVRRGLGKRTESTPAPPKDEGPPPDEYEFSDTESESSFQSPAPVAQHQALTPEVSAPAAKGKFGSKAPKTRKEEKRLSANRGGFITRVSPNLNLGSIMDDKGKNGGERVRWAFWNMGRLFCWAEEGGAVLENLATVVFQNAPTTHALSTLTTTPGRQDIVVGFETGDLVYLDFINDRTERFNVGGKLIKSAVTAIHFDPRGGDRFLASFADNTVAVFHLFAEDPSEAGMAVINSVPRPWDSVFEEAELLAAAKASANPAAAGERSAFQDRVIEWKNTEWAVPADQRDKRGEKYPWAGKNPLSVARLGTDSTLTGMAYSPDGRYLALITRDGLLRLLDTEETRVTDVFQSYFGGLRCVAWSPDSRFVAVGGQDDLITIYSPRESRVVARCQGHTANVTGIAFDPTMRSAGRGYRFGSVGEDGKLLLWDFSAAALRKPRHHHHPGGHGGHHRHGSIGIGSSVSLEKTAEDDGRPNFHPPPSKADVAMLQPVLARQVEGNLMSSLYMGPKTICTVSRAGSMKFWIRPPRQPRKKSTKKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ85</accession>
    <name>K1VZ85_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ85"/>
    <dbReference type="HOGENOM" id="CLU_2529073_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ85"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="84" mass="8527" checksum="D08C5F6288D13398" modified="2012-11-28" version="1">MSTLAPRASSASAAAVRSFTVATSSREGPARTGTGPPVQEGGAPLGSRFRMLPSARFTTSGQPPTLVGGQPPGHYRGLLFSVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZP6</accession>
    <name>K1VZP6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000159">
        <property type="protein sequence ID" value="EKD05032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZP6"/>
    <dbReference type="HOGENOM" id="CLU_834673_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZP6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="333" mass="35741" checksum="C20D7A1A717D8FEB" modified="2012-11-28" version="1">MTKLPHLDTPAQLKVLAKLGGLKIDPQSASFVPQFLRDEAMYRRCVSRGVDCYGPPPSFSPGHDEAGAPLILVTRRACYPCTFSGCSRMCASSANGKVSKFHLRGNGKNSEQAVQVATKRRRVVIGDSTSPSRSTLTLSPQRNNSPSVHGGIPSITSMSEGFSAATLGDTLVERDQETTRLQQELIGAERSLATMTLSAAGHATEKKGMEEQLEETRREAMDATDQLKVAIGIVVQLEKEKDVDAEIIKKLPNIAVILLSRACADGVLVAYSAVIFFSAPVIVVVVFTVLISFDVLITGEAVVLGGEDLFRTLLFIASVFGVDVTRACPSAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W161</accession>
    <name>K1W161_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W161"/>
    <dbReference type="STRING" id="1220162.K1W161"/>
    <dbReference type="eggNOG" id="KOG4031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069856_1_0_1"/>
    <dbReference type="InParanoid" id="K1W161"/>
    <dbReference type="OMA" id="FYENYNT"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="163"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="30545" checksum="E562510A57D3136C" modified="2012-11-28" version="1">MSDDPTADFLAREKAILGDDAHLFASGDVPSQPSGIDAFPDISDSPALSNPASPEKKPSGIDAFPALEEETKTEVRVTGTQGLGEDPERENFEAQFPDISTEVPSAAPVFNALSPQPYGQSPYPPTEKPRTPVSILPAPQFQNTLPETEEDSEPIKEWKKRQAEEIAKRNEEDKKKRDEMANKAEKAIDQFYEDYNKEKEKNIRENKENEAKFVEKLKDDIAKGTAWERIAELIGLENSQSKTIRPTSAGSDLARMREILLSLKRDGDKAPGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1B2</accession>
    <name>K1W1B2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division control protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1B2"/>
    <dbReference type="FunCoup" id="K1W1B2">
        <property type="interactions" value="677"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W1B2"/>
    <dbReference type="eggNOG" id="KOG1173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011751_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1B2"/>
    <dbReference type="OMA" id="WAVTHAN"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="652" mass="71722" checksum="19D70E73FB005ADA" modified="2012-11-28" version="1">MPTHTPPPATFTPQGPARRRLPGSAARISTSFSFNPNDSSYSDVSIMSPSRGRAAFISSAEQGNMSMSQVSPARTPLRRGTANSILGRWSRAQPPGTGTSSRSRLCDTSVEASDELEDLEGDARDNMIASMRVWRGDAAIHNLYETAAFWADKILSLTGQEKYEEALEMIGETNPFRKESIAEVGPLDGIRLHSTMCFLRGILYLRLSSMALAKESFIEALVIDVKNYDAFREIVEEWEFVNNLSYRSQLGPEEATFVRLMYLSKLRKDAHVSEIAAVRRELIDNYGLGDNPDVLVGLAEELFARYKWEDCYSVTSKILARIPGHPSALPLHLACMHYIPRLRSSLFMLAHDLVQQDPDAATTWYAVGLWYFTGKRWAEARRHFSKANLIDPRFAPAWIAFAHSFAWEGEHDHAITAYSTAARLFPGSHLTLLFIGMEHLQLSSSQLAEEFFLASAALHPSDPLLLNELGVTAYDRGDMGAAIKYFERAIAGAGEMQGRTAAWAVTHANLGHAYRISGRYAEARAAYAGCIALDPTNATAYASQAMLAQLEGDVRTAIALYHRALALVPQEPVATVLLEMALKEQVECLDPTTLPGLPAAIARSDLDPFNVSKGNPAFGPLPVEADPKSLEEAGGESLMSDLVEESMEIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1N0</accession>
    <name>K1W1N0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000028">
        <property type="protein sequence ID" value="EKD05672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1N0"/>
    <dbReference type="HOGENOM" id="CLU_1714611_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1N0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="153" mass="16702" checksum="9525A4CC1A239CE3" modified="2012-11-28" version="1">MRSKVLDIQSAAQEIYLMPVQFNSVHHEAPMRLAETSMPGKTSMSSNGRLACLRIKPTTLRSDRSSLGAYCYANAGSSSLHPDVQSGQSMVNATQRCGVENHSFRHMRLALGRREPRGKTPSLCRNILPQGVGAVEREEDSALTGETSEGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4Q4</accession>
    <name>K1W4Q4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3 11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_01871</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3 11"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4Q4"/>
    <dbReference type="FunCoup" id="K1W4Q4">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4Q4"/>
    <dbReference type="eggNOG" id="KOG1112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_1_0_1"/>
    <dbReference type="InParanoid" id="K1W4Q4"/>
    <dbReference type="OMA" id="IELPQHM"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000010">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="762"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD03858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="863" mass="96842" checksum="8305B68B42BDA1E3" modified="2012-11-28" version="1">MVMWIYKRDGRKEPVAFDKVTARINKLSYGLDTNFVEPAIITQKVVQGIHPYITTVELDNLAAETAAALSPMHPDWAILAARIAISNLHKETKKQFSQVIEDLYQWHNPKTGKHAPMVSEEVYNIVSKNKEALDAAIIYDRDFAYNYFGFKTLERSYLLRIDGKIAERPQHMLMRVSVGIHGDDIEKVIETYNLMSERYFTHASPTLFNSGTPHAQMSSCFLVAMKEDSIDGIYDTLKTCAQISKTAGGIGLHIHNIRAKGSYIAGTNGYSNGIVPMLRAYDATARYVDQGGNKRPGAFAIYLEPWHADIFDFLDLRKNHGKEEVRARDLFYALWISDLFMKRVESDGDWTLMCPAECPGLADVHSEEFEKLYESYERAGKGRKTIKAQKLWFAILEAQTETGGPFMLYKDAANRKSNQQHLGTIKSSNLCTEIIEYSSPDEVAVCNLASIALPAFVNFETKTYDFKKLHEITKVVTRNLDQVITRNYYPVPEARNSNMRHRPVGLGVQGLADTFMALRMPFDSREARQLNLQIFETIYHAALEASCEMAQKLGKYPSYEGSPMSQGKIQPDLWGVEPTDLWDWTELRANIAQHGVRNSLLVAPMPTASTSQILGWNECFEPYTSMLYSRRVLSGDFAVVCPWLLRDLINLGIWDEEMKNLIIASGGSIQHIPNIPDDIKAIYKTVWEISQKAVIDLAADRGAFIDQSQSLNIHLANPSFSQLTSMHFYGWKRGLKTGAYYLRTRPAANAIQFTIDAKTLKQAKANESQGSRPSSRNTASKPAPSVNELTEPMRKIKIETTAPSQVHPAVTAASRARGGSESPNPSENEEVSYEEAKRRADERAAAALQCSIDNKDACVMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4U4</accession>
    <name>K1W4U4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4U4"/>
    <dbReference type="STRING" id="1220162.K1W4U4"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318893_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4U4"/>
    <dbReference type="OMA" id="ECTREYF"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001104">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.234, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="222"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="868"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="780"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="912" mass="97581" checksum="3515F3FAE7E7A3CA" modified="2012-11-28" version="1">MPSPSSQAPALTTDSTAQTSPTTPATTQPKSAPSTAGRPSLLLPPGGPPATIVSPPTPVTPVDNPLQLGGSAVPSEVLILEEPEEYESPGEDVETASTASSSFVHTPAQQSMNVPPQFSVSRGNSSSSSAPAPFSTPYDSMSPGVTGKNLSSLVANPAPTPSSPRVYMPRIPSPSAGTQDSRPQVTGKERRHRRESSTHRVRETIYGETRSTVDGQRMVNQYRLGKTLGKGSYASVEHAIDVGTGIEYAVKEFSKSRLKQQALQERQAKAFRERRRRPRPGAPMPRKQGDGPAMDYVYGGDDDMEKKLRDDPLFLIRKEIAVMKKLEGKTDPQVVHLFEAISVQNADSLFLVLEYLPGGVLMNVKLGQDDKDAKPPFSQECTREYFRQICLGLEYLHANGVAHRDPDNLLFNSDRTMVKLADFGVSEIFATTDDDRIKTTGGSPAYLSPESFTVSSMDIHGKAVDIWALGVTLYCMLTGRLPFNASNTIELFTLVRETDPVIPDDWNPALKSLVTGMLCKDPERRATMEDIRRNNFVTAWGEQPMMSEEENLFHYGKVFEEPTDEEINSAITSLKRVFTVIRAVQKMRRLGLNRLSMSRSASMNTGSMDSYALSEEGEEREPPRILSGRLVGDSHSPELVESPGSSMDVALDPMDKAAVASPEMVASPEMVASPQMVDSPVMAASPEMVASPVAASPEMVATPIECASPVECASPLECASPLAASPIQLHSDLAPGSPERISPSKRASSTGQGQAPAAIPAISSPKRNKLADYVRRVNISPSSPGASNVSSSPGAASRTSVKSNLSSTATPAAENEGEAEGKDSAGGSERPTPVRGKRETLSINTTDIPSTGPTKLVEVVDVEVAPQSGAPASPVEFESPVQVQSPEMASPVQVESPVECESPVECESPGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4V5</accession>
    <name>K1W4V5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4V5"/>
    <dbReference type="HOGENOM" id="CLU_1397230_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4V5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="198" mass="21478" checksum="B5BB51330A3B3C7E" modified="2012-11-28" version="1">MSISETTATLLKRRDVQGQIITWNLDDDAPGARQIAHGPGPDVGEELIDAVIEALEDYIMEDTMVQSLAMSTDWATIVIDDFRGMFGSHTLKMMANEDKAGRPLSQPSDRETLDDSESTGPPDDPPQANPNELKGYIATYNVSPGAPGPHSRGIEVDNLWNLRALVAELKNVKDKGVIVSVMYNCETAIITVDAPNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4Z3</accession>
    <name>K1W4Z3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4Z3"/>
    <dbReference type="FunCoup" id="K1W4Z3">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4Z3"/>
    <dbReference type="eggNOG" id="KOG2963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026936_2_1_1"/>
    <dbReference type="InParanoid" id="K1W4Z3"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="25"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="454" mass="50704" checksum="0275FF77249817EF" modified="2012-11-28" version="1">MGKRRRKNRTHLKGPQPGEEADKVPKSFVIKSGNVTKSVGALVRDVRKVMEPNTATRLKERPGARLRDYLTIAPTLGVTHLMAFTLTDAANVHLRVARLPQGPTLTFRVLRYSLMKDIVNAAHVMRNLGGKSPGGEYRNPPLLVLNGFQQPADGQPMPQLKLMSTMFQGLFPPIQVEKSALPTFRRVLLISYNHSTGLISMRHFTITRAPDLANQDDIADYLLRRADRAGSASTDGYDSMSESEASEAESDTNAVELPEDYVGRGNKKGERKAVRLVETGPRLELKLVKIVEGLVGSKRGEGQTVYHAIETRTKEQESKLQRAHDERKKLKEKRKAEQAANVARKKAEKAARKGGKAEEDEEDDESEPDVDGLSDYGSDEDPEAALQRRRARFAEEKDEEDDDEFDYEDRAADEDEDLDNWDEDVAAGDVSDEEESDDESEDEAPPPKKRAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W585</accession>
    <name>K1W585_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid particle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W585"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027968_0_0_1"/>
    <dbReference type="InParanoid" id="K1W585"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852271" evidence="2">
        <location>
            <begin position="17"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="567" mass="61692" checksum="7697F8760FB19106" modified="2012-11-28" version="1">MATDVHLCLLLHGLYGSPSNLWCLEEEVERAHNSAGSHLELAVLNATSYSGPKTWDGVDVIAHGVAQEPDRKRREAGRLLECGLIARTLIGQLYARPGFFARHGPAYFSTIATPHLGVLRYGSWRSAWMHAVGQHMFSRTGQQLFCLDSDHGDPFLVVLADPSRIYYRALAQFTRVLFIANGVGDLTVPYCTAAAERHDPFVDYEAGRLGLVVHDHIVRNVFSPQEEDEVDAIVGETLVPAAPTRPWLPPVFYLPYRPVRYVSAGNVRTSLEGWRALPYDLSAPANDRSSSLSSPSSSPWPSRFAAAAMAVHSYHSSRRIRALAVHHDHHHRIFGLESSDYDVSGDTPAITRPGSPSLGGSTIRGSVMKELYKMSAGETDDRDTREGTADPCEVCEDAEETGDADGGEGGPILAETGDVDAGQPAGPALVPPSQPILTSQQEAMVTTLSALPQLERVVAWFPGVFNAHAVIVARNARIPRWSWQGIGRFVISEWAQKCVSAVQAAAGRPEPDFSTLASEFSREASEAMDVDTPTESRRGSREPTAIEISVSEMRPSPSDSERSHSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W601</accession>
    <name>K1W601_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W601"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842478_0_0_1"/>
    <dbReference type="InParanoid" id="K1W601"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="35019" checksum="6E0AEBA78F34F368" modified="2012-11-28" version="1">MLSRIRNQFSSQCHDDYEPVQSDDGPNLPPLEIHRQRPQRGEMQSRSGGLVVACFWALGAGILLSWNDDTDETAAMVTDPDACDHDRDGLPSAVQHPSLHVDLGLSAAASDAPAHRAGALPVHIETLAVMSGQGGVACIVSLAQVFLAMAESKNAGIPENGHGSTKAAQALWFIGAIGTIACIAALRYLVSHPDYVIVLAPLAQREVSVDVTSKDMTKRVFAKNITLEFAQLTTGYLPSHHNDDHVREPQPAMDSAACHLHRDSLLHLQLAVGSICMIFASSPELNPVIGEEEKDLAGTLAAFSLVAGLAFGSLCSFAVNYAINGNPFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6B4</accession>
    <name>K1W6B4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6B4"/>
    <dbReference type="HOGENOM" id="CLU_1027399_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6B4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="262" mass="28267" checksum="E8879A160FE860F0" modified="2012-11-28" version="1">MIFTCSFPKNNTVEAECCKYGPKPEQLSSFTLKQDQATYCAVDKLDYLIGCLADHSITVDECRVDGINTATAAKKSYASASSPPTRLGMLCLTLLGLSLLAGVSAAPASNSTVCKTFKVNSESKSDWDVNARTSLSPLYQGAADCRGSSRCSLKADDEMRPTWKAEWFAPPGVEVHADFKAIVSKANELDHKVYGEAVEFPKVPEHEQWAVPPGAVVNVKGQASATRIPGTFSDCDNEQAYPGSVLLPRADQFWYKAVQGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6K7</accession>
    <name>K1W6K7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MMS2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6K7"/>
    <dbReference type="FunCoup" id="K1W6K7">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6K7"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007931_0_1_1"/>
    <dbReference type="InParanoid" id="K1W6K7"/>
    <dbReference type="OMA" id="MDLQARK"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005686838" evidence="3">
        <location>
            <begin position="21"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="778" mass="85954" checksum="5E8D793053768641" modified="2012-11-28" version="1">MRRHLIHLIAALLLVLLVFADERARNQDEGRKATLVKGQVEEQQQVLDVDVPPEIGPDVGRERQANAERALDLIDDAVENGCLEALALRAEVNMFPPRGIAQNLTAAYEDYESYLDGYTSDPKAQFMLGFFYATGLGGAPRDQARALLYYTFSALQGYKAAQMAMGYRYWSGIAVKEDCDLALDYYESAARNAFYAFNSGPPGGKTLLLSPSRLSDRYGGIFGPHASWASTGVMAHRAAVKASQAKERGENEAEILEFYQYRSDRGSLSYTYQLGLLFYLGSVYGHGVGVSSGAEVVGEVPRDYAKAQRYLYHVVRQLWPADFDAEGKIMPKKKMSKESEDAIRKYAMSAASLLGRMALRGEGMQQDYRAAYLWYKRAAELGDPEAHNGLGIIYRDGLGVNVDAKQAMKYFKSAATAQLPEAQVNLGKLMSASGQDAIKVFEAGIRSGSPFEALYHVAEHHAARSRKIADEGIQDHLSVCGIATIYYKIVSEVGSWGEDFVGDADRAWARGETNNALVGWWLAAEAGSEIGQNNVAFLLSRGLGKDVDAPADSELTLWMRSAAQDNADAMVKVGDYYYAGLGPNENATAPELPTGEHGEPDYAKALAYYQTAADKQSAMAYWNLGYMYENGLGVPRDWHIAKRQYDLSYSQTPDAAYLPWLLSMCKLYLRSWWVSFRTGGAVPGLGLYDEDQAPQSLWEGLKGLVWPKYDGYVPEQDEEVEDYSGAGWAQQQGGGQAGDDEEFDEVDDIIESLVIIVLTGVIMVLFWIRGRMVNRNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6V3</accession>
    <name>K1W6V3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6V3"/>
    <dbReference type="HOGENOM" id="CLU_1817157_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6V3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="142" mass="15423" checksum="EDA520E7B2AD28CA" modified="2012-11-28" version="1">MVAVLHSSAPTPPDLAEGIQILGSLAHGALFVLEVIVNLAPLALLAALVVCIIGISPPSTDPTSSYTNEDEVSETFAERRRRRWRRRRQRAAEERMAKYHQCQGSLPRPLPPFSSDGWSSDEERAPLGAGARVLTYGSIGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7S2</accession>
    <name>K1W7S2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7S2"/>
    <dbReference type="HOGENOM" id="CLU_1240900_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7S2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="223" mass="25032" checksum="8A083649055ED718" modified="2012-11-28" version="1">MTAAPTILEARCDVWTCGGSIPDVPLEEVEYILNHPGMNGYTGQPERIVSMARFMVTIANEFLMCYLTALGCLDLAVHIDPNAADAVTHCLAYVSPCQWGPAKFVIDGCIQNLPQDRIRLRAAVTRGLVPRTELAEFDTWHARAKAAKATFDWVLKRLERCGRRVTPGVGFDGEALDRLTEGRIVATMLNLDLDQKRCLERMEEAWSKNIEREEARQHQCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8X8</accession>
    <name>K1W8X8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8X8"/>
    <dbReference type="HOGENOM" id="CLU_794976_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8X8"/>
    <dbReference type="OrthoDB" id="2595522at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="349" mass="39058" checksum="68B3467E2602B13E" modified="2012-11-28" version="1">MATTTITVEEDDSTSISADGYPHIIDEIFGYAPRSTLLALRGVCKAWRDRVDLLMAGHIVLAVYSPVEISGRGGVRIPGLKNRRNYARVLSGTRVVDLLGPQSLSPDRVKALRSQLNDVSVVRHRHHPAGRLPNNALVGARTLVTFTTVTEKYEGGTFTGAAAVGPLPEACERFVLNVKFDPGRSWLSTASVQPFQTPAQLKSVTLILTPIATHKEDENDHWVGNFVDSSRTKVMGMLNSFVLNMTLNIPRLRYTIVDAEQLRPAWLGFAPEDMQALEEAWLDNFGVIPAREEVLVAEIRRQVKQGLKKWNQVDDETAEKQVEEHVRFLTRDQYRDEVGEEEYLLETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA25</accession>
    <name>K1WA25_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA25"/>
    <dbReference type="HOGENOM" id="CLU_1332767_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA25"/>
    <dbReference type="OMA" id="ASLWMAM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="22170" checksum="6A336BE192602CA6" modified="2012-11-28" version="1">MWTQRRAVEMRRRKRLKAAKSDPPKPPQADPPKEAPKADPPKPKEGAKGDIGKPPAPPKFGGLKKAPPKAKEKPPPKPPRQFKMKKDDAPKPPKPPKEKKEKPPKPPKDNSAKAEAAAKKKADAEAAKARKKSDAEAAKQAKADAKAVKKAAADSKKAEAAAAKKKAAEDKAKAKEAKKSKAWAKKQADAAVRRGSKLYKPPPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEE6</accession>
    <name>K1WEE6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEE6"/>
    <dbReference type="HOGENOM" id="CLU_1235805_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEE6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="224" mass="25849" checksum="C7C834E16F11734D" modified="2012-11-28" version="1">MVRHDANFYLHIETPASPAKEQLQIVKHRSDATVERVIKRYGNRRSFMKMLDDEDMGNLAVVFAFRDECPCECPYTTKQHADGCPLSLRPAYWLFKRGGFLSPKEQDELWHAYISLIERFPDILKKPRPVHSASKAAARALEGPSQHHPAARSAKHKPLHLGYWRRRSGQIHLTADTLQGGDYDRQLAIFGFMATLDRILYRNRWKAKQVDKDALHLDAKVMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFV4</accession>
    <name>K1WFV4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFV4"/>
    <dbReference type="STRING" id="1220162.K1WFV4"/>
    <dbReference type="eggNOG" id="ENOG502S6XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877700_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFV4"/>
    <dbReference type="OMA" id="RIMIEEM"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="35425" checksum="7FC3BCE0E17A7B02" modified="2012-11-28" version="1">MQSSTRTPKPSEPTALEKQRDWFRSSSLLENRDARPGSVLARKEQQKGEFRLLKQRFLDSEAKRQFLFAITGESPSLAPGENERLERENKEKKAVLKEKKAEVERLRVEIGEMAKDNEQKHAELSEKVAQVSKLQKEIDSMELELARLNAAHPPDSRMTMAEASETLDKQTERLEELTSALGTADGRIAELSEALIARRARVAQLSKDRQREEARAAEVTKLRSMGDNHALQLADWFGRMNAQYRALLGIRGMSVENGRTTVEYEEGVTLTMDFAPKLVAADVTGTNADMTEAINAAISANDPAGLVADILVRIRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH48</accession>
    <name>K1WH48_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="4">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH48"/>
    <dbReference type="FunCoup" id="K1WH48">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WH48"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="InParanoid" id="K1WH48"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000082">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="264" mass="29332" checksum="F40738EE8EDBB65C" modified="2012-11-28" version="1">MSEHRIIDMSTATTTGEDKYSVILPTYNERKNLPVIVWLLAKMFEENNLQWEIIVVDDASPDGTQDIARQLGRIYGEDKIPRAGKLGLGTAYVHGLNFCTGNFVIIMDADFSHHPKFIPEFIKQQKMHNLDIVTGTRYASSPSPASNGRVGLGPGGVYGWDLKRKLVSRGANYLADTVLQPGISDLTGSFRLYRLPVIRDIIGRCTSKGYVFQMEIVVRARSLGYSIGEVPITFVDRIFGESKLSGNEIVGYAKGVANLWWGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIE2</accession>
    <name>K1WIE2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIE2"/>
    <dbReference type="HOGENOM" id="CLU_1027400_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIE2"/>
    <dbReference type="OMA" id="YREEWAE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="271" mass="28988" checksum="4768E06F99689CBC" modified="2012-11-28" version="1">MTVLGRASLVRRDTLPASKIGLIAGVVGGVTVVCFALAVLVWKLLYVPNQHQFDEVSIERASTDSLSSEHRGYAGMLHRLRRASSPGIERTLAEHTLKEKEKKSTGPSLPPGAMAPAMPGIPEQQPATPPMTPPGRPRMPRRLTSPTPPTLGTPIAPISEASSAPSTPVAPITPLAPTAPDSAPMTPIMRPTSPEPPETPPRFPIKIRHADDSEDLSIELLPPLYREEWAERRSLHLEEAASEVVRIDSILVTSALTLAADAGPPLRSQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM32</accession>
    <name>K1WM32_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM32"/>
    <dbReference type="HOGENOM" id="CLU_1807586_0_0_1"/>
    <dbReference type="InParanoid" id="K1WM32"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854845" evidence="1">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="149" mass="17163" checksum="B1D10040D22FA1CF" modified="2012-11-28" version="1">MLYSSLLLIALSSSTQAKLWGWPEDDFSIHKQELQANFKPQSLGSESVFCPGWGKWCKGDKGNDPSCETLNKFVYSGRMPVGNFYIEKPNSAQIDLWRIEGTETYNIFERGGDGTIHGQCQLHKSFREACQYTGFTELWIRPMLHCWQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WML5</accession>
    <name>K1WML5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000289">
        <property type="protein sequence ID" value="EKD02369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WML5"/>
    <dbReference type="STRING" id="1220162.K1WML5"/>
    <dbReference type="eggNOG" id="KOG1710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351319_0_0_1"/>
    <dbReference type="InParanoid" id="K1WML5"/>
    <dbReference type="OMA" id="GGAWKRW"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="820" mass="88673" checksum="1875C6BE7875FDEA" modified="2012-11-28" version="1">MTVAWKLAMGKSDKDKPKEVPAKPTKKSKTINKVARNGTATAKKVANDNGNSTANNSTNGKEQPTSKVETTDGNAAPGPTPTNANSPKVEPPKIAPLQKVCMVDAPGKAVAVITTKQEPTTEASKDDTASYNASTVNDGPSLPNANQAPKNVASKGSTSFSKRGHFMRRLSRSVGRNVSENKGNTNNGNISGAYLIEPLTEDRANNEHVKTVSDTPADPGTDGAKNTAPTSEPQPETVAKAVLLLGTPSSNGDAEPATKPTNAEVGSSRDIKRGSAEVCPSNTTTTPTQPIRSLATTRDILLAASLSRQGSILPIASYPKLSMSTPLTEEKLKLDERSHVKRLFRAVGNEDVTTIVSLLASGLVSPDVVSAGGITPLVYAAARGLFDSTEALIMHSADLNRMSEASFAAFKPTQVASASKLEDGMQTSEPRTALMTAAEHGRLRVAELLLLAGADDGIIAPDGQIALRLAALNGHHDIAEMLPERNDGAAERIAYKLAPARSHMRNAVLCIQIVWFITVFISAWVWGLMLKACKLEESWARFCASVKADLILIQDGWKWTKDKFMAGIEWFLAYWPLLIAYGEDVVYWLWHQAKDMPGKMKLFCHNVPGVARRCLRAAEEIASEAVEWLSAGLDSLGPRYNYAKTVVSAQSQKVLYNLHLVARQLKPVIDDTVLRFKALPSAIQLYAVWAFYTLCHSSIALVGALLQFISLAHSTSLAIITWFKDVTAEDLRNGLVQLGNALVDLFIILHVQLIRLVHTCSIVVFRTMNWTGAAVYWAGYAVLELVGFIPMCILKALWAVLRTVLFAVHEGRVWFNPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMX0</accession>
    <name>K1WMX0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MUTL-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMX0"/>
    <dbReference type="FunCoup" id="K1WMX0">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMX0"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="InParanoid" id="K1WMX0"/>
    <dbReference type="OMA" id="MCLIQHE"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="2">
        <location>
            <begin position="54"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="478" mass="52489" checksum="4875E4CB3EAAF797" modified="2012-11-28" version="1">MPLRKRAFRSTSDEYGRILDVVTKYAIHNPHVSWHGIAAADLSTNANSTAKANISHLISSTLAQELIQIPDTTFDAKLGTRCHGWISDGNWAPKKGGFILFINSEACTDVTNTRSPGGQHKAEKGSRGRIRDGTGEGRVAVHLSEVGRHPTPSDASLRIDPAKIDVNVHPTKSEVHFLNEDEIVVAVVGAVEQALANANTSRTFAVQTVSTSKSDTPARRAAAPNYKVRMDPANRTLHSMVAVVNPSQIAGPEDTSRTVDATECDFTSIQELRQAVADNSSSGLSEMLATHAFVGGECFAGPADPRDEHFYQLGLQQFGGIGRLKLEPPPPLSELIKVAAEAEPDIAKAGLSVDQVVQMLDEYFSITVSADGHLEAIPLLLKGYTPDLDRLPHFLLSLAHRVVWDDEKECFDTILREIGFFYSPRPFGSPPEDGAHRQWQLEHVLFPSFRRTQWPRRLKPSAKQVANLPDLFRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WN17</accession>
    <name>K1WN17_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Muconate cycloisomerase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WN17"/>
    <dbReference type="STRING" id="1220162.K1WN17"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402899_0_0_1"/>
    <dbReference type="InParanoid" id="K1WN17"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="34"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="683" mass="72828" checksum="9C2FBDEF98DFACB0" modified="2012-11-28" version="1">MASFEAQTLSFGDGRRIHCLVSRGTRPQDGLTPVVALHGLGGSSAFWTPVFTASPELAKRDIYVYDMDGHGLSPFSGRSDGGIAAYVADLKSVLEALGLQKVVLVAHSMNALCVLSDEHWAQGSGSWKGWEVVSSGTGRPADDTQTVTSIFAQENPSFVERLVLLHPVRNLPPAAKEGMSARASAASSSEGLAGIANAVASAGVASASRSNSSITSFIRDLVSTTSPEGYAAACKALATAPDVDAAKTPVPVYLIGGAEDYLAGPAPVQAWAKETQNGHSVILPRVGHWGGIEAPHAVANAVQSALAPESYELFVGTFRSPKLYTIRFEPGSKKLSLQTTNDALSGHNWLDVSRDGKTLYATCWGTGAARVTCYDIVPPGKVGYHTAKQATTAPSKYMSGYVVANAKAIYSACGPQVDVFELDDKGKLKTGEAVQSFALVSENGRHKGDSVLDFGGLRHGGHSADLSPDGSKLYVADIGRNCVWMYHVDPATGHLKEASKNIAKRGHDGPRHAWPHPNGRIVYSLQEHSSYVDVLRLSDDDQSLEWVEGGNILPPSDDCGLYWADEVRLSPDARTLFGSTRGLKPETKGWVSAWSLDENGRLKTADEQPQHRFQTRTSGGWANAIAVAPNAGPRGESYIALTDSEEGFVQMLSYTEKDGFEVLDELKLGEKGEEHPVSVVAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1WR56</accession>
    <name>K1WR56_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_02237</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WR56"/>
    <dbReference type="FunCoup" id="K1WR56">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WR56"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010975_1_1_1"/>
    <dbReference type="InParanoid" id="K1WR56"/>
    <dbReference type="OMA" id="DMDPKMG"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="19">
        <location>
            <begin position="9"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKD03519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="798" mass="88763" checksum="326F485EA7AA323C" modified="2012-11-28" version="1">MAGRGGYCVVAYCVDVSPSMGEAMADPDGTGIKRPKLAWVKEYVAREFEPKSGRKTDCIGLVTFGGNAPYQNVSVDVAIQTAKPAALETLMNTEQGDAEGNPILCALDAIQMHKHTKMWTLEIVLITDGESGFDQGEYEEAMETLDRLGVKLTVLGVGFDDPEDNVDKSKPKPKRLSEKFWRVFIRNLEEQISKSSTEEQFRPELKVFEPQLSQIRMPRPDVVNGTQVGTCLYIGAEPIDAEQAICIPLKYTKATAKARPPTLSKAWKTAVDLQQPAGTIPTHSEASQLLNTLQSQSQSQGGQANNLAALVSAEVKQHSTYFLKKPEPIKESGAGEAEGDDLPTIEEDEGEREYIPKEELVKAWRYGSSWIPVEDDTFEPLKTQKGVEVLGFIPQKNYMLIGEVRYLWPDLKSSKAQIQFSSFVSALVTTGMVAITRWVTKDGSPPEIGVCIPKQEFGDEKRLDLMYWIRLPFADDDHRFFFPSLTNYKSVSGNEITEHPYIPTQEQSDLMDELVKGLDLDSVTPEGATQQDDEDEDEDGEPILHSPWYDPAFSYNPAIHRTKQAILHASLTADTKADPLGPPHPELTKYFYTPEKLVEQTEKITERLKDALDIKKVTRVQRKKRQIDIDELFDNPGPGKTETVSPAKPKVAADVDKKPDFADDPDFILPPSADAKPKPGRLISNLRPLEDFKRVTASGDVFKKAIQDMGVVVEENVAASFSKQAFPDAIACLEEARSTALMYEETETYNEIVKNLGKAVTDPSFKHKDFWKTFKAAGKKVAPISEEEAAAALEEEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSQ8</accession>
    <name>K1WSQ8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSQ8"/>
    <dbReference type="STRING" id="1220162.K1WSQ8"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282450_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSQ8"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="443"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120799" checksum="642DACC239F78937" modified="2012-11-28" version="1">MKLEAQGWDFPIDLDGHGWSSDDGDSPDPPPVPVKDTVYPPLPDVGAMTANLDYPAWAAQKLRQQQSSFELLKAKLTATPSQPLLYTGAKTPRSIPSAGTYTPVPSTPKKESITPPRDEAKPSRAKTPQTGITPQFSRVSVKQPPSAPTPVRLPKLAPKPTANWSLNSPLNAVPAGSEYLEVVPRNPYQAYLNNNVSYYVQWELERQLLLAGLTWDNVRFEDFEVLRGEAVTAMSSVPLVVHKIGTREGKLVEPDTSTVPARTLIEIDQEERSIMDQDLRGVQNDSRDWSYGGKLMLAVNLEYDIHPTSPPCPPDSFADGNPFAPVWPFNMQLQPIEMPGRSNRLARRFGSRRLLYLRFGSVPRQQRDLVFGLFRGHGLVLFGRVFRVLYIPADSDTAIAIQVDEEAPGAPALKEPKVFSFLQLLGLIPDIVCLTATNPSDPEACEILSDGCGLMSQKILHHPFFADLRWPPCSVQMRLGGSKGVLSLMSREQEEEYDADVVLRPSMIKSKSAAGFSDDPSVLTLDVLKVDGLKVGCNLSSEAIIIMEDRGVPPDVLIAKAELEFEKIRESLLPVPHPGENEDDVRQRLLHAVYTLGGVGSEREKRRCRQLGKSTKVAGLSLESTQQDEYEEDTSVAEKSLTDRAVSDFKLPVDQSLSALIVPDTLGVLKPNEIYIAPSSAALVNPSTMRPMSCVEGDVLIFRSPCKLPTDVRKMRAVYHSKLKHLQDCIVMSADSAMCTASPASLLAGGDYDGDTATVIWDEDLVKPFRNAPEPDLDEKKFQAENFNKEVVAVIDFLHAVRGRSHGKEEEARMIINLQHFLLGGIMDQQLTGRYSAMHDYAVYTLGPSHPVTVRLANMFCLVLDSRKSGLTVKPEVLRADLQRYGSQEVFWRKFKKGQLDGEYNISYAKRSKDLPEFISAQLHVLQAFETRETPDDFSSLLDEYTTFRESMEDEETNLQLSVLNKHVTACVELLPLVYFSGEDLGDAYMKRLKNGRFYQRQAWPQESAADDASIASSLSSSRTNSSKPTSTEIFRRMNALRQLWTSLPKPSKISRLASLGSARLEELKILCCIDICARSRRAVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVB5</accession>
    <name>K1WVB5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVB5"/>
    <dbReference type="HOGENOM" id="CLU_336838_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVB5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="846" mass="92404" checksum="AB72597E0A135DF0" modified="2012-11-28" version="1">MSAAKKRRRSLNSKYDGLLKSGHSLVTNSHSLVLTPSLIPDKSRVQASSTRVRRDRLRNRQKLWDDLGFGPVDVETQAAPAAPTLDLAWPARADTFAIPPSSPPTDNLGTHSQLQPSPRRADGSTFTSEWPFEPQLEPTPEPRASAVDLEESARRLSCPPQPAPIQLLWTPHGIISCNGEPVELYYPPNMNSSTLATSWPSHIEQEVPQNVNILHPDSGRPHPEPWAHPTSVHDETSVSDGSAMRDTDIPQAMMRSRRFLQPPQQDDPPPRHIPRDDLSDSLHSLTFDEPDPSAVGNVSQLALDLDEKPGYHDDIEEGLVPVFDGRSAHSKQPDSHSAAEGDVLDAKLLSDSATQINVNESTAINECPISGAVQRPELDYGRHRSSLRLPDKYESSQHPAEVVVEEGGITSSKQSRVRLEPLLSRLVQARSQLTMESPRASSQSGTLSPPPRASRTPYAPRKMTPKHTLRSQAPAPHTPTLRLRKPPVNHRLRAPDRHDQESVQLLQIAPSPPPPNANTDSSPLQKSTSPQPLELSQQNISDGKETVDYGSEDELLLQPDAPAERLAMATEIMSSIGGFGSRQTSVGPSRVTPTLPPGATTTPYHKPGLHTLSQTIFKRRPEAWANLTYLQQPGTNSLDPKTPAPPTPTIAPVDVWLSVGGVDEGDKRLESIGEVPELEEIEVDEEESESDEKAPDTDVAESIRSFTPSQEKPRKRKKKQVRFNLDHEEFFYEPEPDARRILGLLKPRLDDEHDVGLATAVYQIGGGTKSSQQQQNSEAAKVAKEREASLSPASPESPASPAPCASSPPPAPVSPAPASPVSQAGTQTVPEDNKNDIGFTIYRDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1WW08</accession>
    <name>K1WW08_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD04994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WW08"/>
    <dbReference type="HOGENOM" id="CLU_1147878_0_0_1"/>
    <dbReference type="InParanoid" id="K1WW08"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="242" mass="26745" checksum="8B8B910670354139" modified="2012-11-28" version="1">MNRQHVRPLFADIQGGDCQLPAMMGYIRQLVDSQDSRAVAHNAATAYLALIMAFSDRGLLEVAWAPRLLIEVDNQEFEIILDDPEMVETAITTRSSDQVSHSLAIMKKHNRPRPLAPVKGRLDAFLTTIATGDWSLLANPVSATFVENEQHGEDTVPGKDRALQTVVNRLLALEALDRKELSLSVATNIAYWKLGEAYSLFAESKGPLLGGQRNSRAEQKAIFDLLCSERDFQAASNSLRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY25</accession>
    <name>K1WY25_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000089">
        <property type="protein sequence ID" value="EKD05564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WY25"/>
    <dbReference type="STRING" id="1220162.K1WY25"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="K1WY25"/>
    <dbReference type="OMA" id="WITIGEI"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52469" checksum="D1430B55A037ED8A" modified="2012-11-28" version="1">MTIDDKYDLDEKEIVECVEESRLRSNYAELSPHQARRKFWRLYFMAMSLCIGGMYVGYAVVAPGNVVANPGFIQVDPVTGATELDAVHVSLWSGFTIVGQVCGMLIAPLGDHVGRKPTLWLMTALMIGAIVMEMLANDWKVFLGGKILTGVSTGLAMAAIPALCAELTMPQFSGDVMGAFALGFSFGQLPCAVGLEVLFKTDPHEFRRIFYAQFVVVGLWLIPLFIVPESPLWLASKGHHDKGKKALRRLVGNVEGYDLDHEYAVIAAQHEASARASKHSWITLLRGHNLKRTLITCIVPTLIYCSGQPLIYGQTAYFFQTAGLEDPFVGNLIITVLTIIFVAIGNWIVLPRVPRRKATLTFLVCSVPLLSIIGGLGCLPVSRPVASGLIAVCSVWVSLFCATVAVIYWITIGEIPTASIRQMTITFALIFMSAWGAMWTYVVPILLSPQKADLGTKTCFVFAGVTVPFIPREYARLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0K4</accession>
    <name>K1V0K4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0K4"/>
    <dbReference type="HOGENOM" id="CLU_700551_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0K4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="393" mass="45172" checksum="AD614B105E799903" modified="2012-11-28" version="1">MADQPAAEERKLAETTGLTLSEYCELCEFATYDVDVLHVHYNRVHFSDDHEGDELFAISPPGTPKTHASPASPATPRTPDESEWLSRRRPAYTFSDTLPERLHIDFGEALMLLSFLLFGNVDCGMVWRFSPKTTEEEIHAFERNNQLDPAKRTRANFENLLRMQPALERVCDEIGSMSYYKMRFRPWAQQRPQPPVDYSDEDDGYFIEEYESPGLTSDEDEGVGKDEEVHSPPSSVPDSQGLQLPSDSKEDQASSDGSAPASPASLASPDSPMPEYTYLTDAEYAKLRHDHLLREYEDEFERSLRFAFGEDQGQGYSILRTFLNDVKKANARTMREWEVQEEKRRERGWLYLDTREWGDAYRPEVDYEPVLKEENDESEDDEDLIDGLYVRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2T6</accession>
    <name>K1V2T6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2T6"/>
    <dbReference type="STRING" id="1220162.K1V2T6"/>
    <dbReference type="eggNOG" id="ENOG502RZQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068101_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2T6"/>
    <dbReference type="OMA" id="HHEMASQ"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="326" mass="36537" checksum="7C7215FED894A806" modified="2012-11-28" version="1">MVRKIPTQVPQQMSRMLESKLVQQPPTWWGAVLANPPPVLPPRQVTPRNRPDATLKQYPDLEEAHFAQHHGRPHSKNHKQKHLKEIKPKPVQISYAIDKIRRQFFADFPFEALRPTSISEGIDIADENPVQGKNWTKLVQRGRYPTVEDTIQFAQKLHAEDGMALQLAYDEAVSQFCQLRAHHEMASQAAETEARHYGAHFKRDESDLQTRTFDKERSALARTAIEQSDDPNAAAGNTGLKWIRKPKVWASDVPAGTIPVGEFTGAKTYVAKWSLPAPARWAGANTEEPKGELLKLLGRKARAPPPPKADGEMDDAQLLAAITGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4D3</accession>
    <name>K1V4D3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4D3"/>
    <dbReference type="FunCoup" id="K1V4D3">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V4D3"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="InParanoid" id="K1V4D3"/>
    <dbReference type="OMA" id="GEFACIC"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="11">
        <location>
            <begin position="124"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="11">
        <location>
            <begin position="239"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="312" mass="34209" checksum="F40F5B1883640B69" modified="2012-11-28" version="1">MLEARVKQASVLKKLLDAIKELVTDGNLDCSDEGIAMDNSHVALVSLKLVADQFESYRCDRNIPLGVNLTSLTKILKCAKDNDVVTLKAADDADSLGLVFESPKEDRVGEYEMKLMDIDQEHLGIPDTQYDATITMSSQEFARICRDLTALGESVKIEASKEGVRFSSEGEVGSGSVLLKQTAGSDRRTRAKTDPDEEEEEEDEKPDVSEGDGEDEIDDEDRPKKRKANGTSKTASKKGKAAASDEDVGVSIILEKQVSLTFSLKYLSNFAKSAPLAREVSLNMSNDVPLLVQFDFEQGTLQFFLAPKISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4Y1</accession>
    <name>K1V4Y1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 8">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 8"/>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4Y1"/>
    <dbReference type="STRING" id="1220162.K1V4Y1"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_89_1_1"/>
    <dbReference type="InParanoid" id="K1V4Y1"/>
    <dbReference type="OMA" id="EGTTHEG"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="216"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="760"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="803" mass="86282" checksum="DA361C2C08AC01D4" modified="2012-11-28" version="1">MPTAISPPASPAPPSTSPIKAVLPRRAKAVAAADGIAAALPSARPQSAATIPATTASLTTGSTAASSEVPSPAELESGGGPSNTSASGSGEARDAGPGELRPSGNSDLAVPNVPLSPASVAAGSNTPASGAGSQHVASAVPTPFGDDAAGTATSTTASGRVTPATTHGASMLAQAARRGMVEEDKDEHPLSDRKLAERGYHTIHAMNHLFHVPDRWRLLRPLGQGAYGLVVSVQDTVSGEPVAIKCITRVFDKPILARRALREITLLRHFGEHENLTGLIDLDNVWDGYNEIYLYMEPMEADLHQIVRSGQPLSNLHIQFFLYQLLRGVKYIHSANVIHRDLKPGNLLVNSDCELKICDFGLARGYQPVTGEAPQNEELRMTEYVATRWYRAPEIMLSNKRYTSAIDVWSIGCILGELLGLKPLFKGKDYVDQLNLILNVLGTPDDETLQRMSSEKARMYMATLPHSEKRDLAEVLPGADPAALDLLAQLLSFDPSKRIDVVQALEHPYVGAYHDPSDEPTCEPFNQWEQVEGLETTEELKAALTKEIIEYRAEVRGMAEQDMLDELEQQRQQQSQHLAVQPSADVNMSQGKRVADEDLYVDAAKRQVVEDSDDEDSPVVIKSKLGLAAQAGRSPRIGGRKRLESDASVRSVASVASAVSSSSGASVVPGSQIVAGPRHRRSSSRSSVRRSMSLFGTVGGMAALAMTAATPKKEEEDTASEGIYSSMVERRNRAASNTTVDSLRPLIRHLSTTSLADLGIKSPDALTDDEPLIRHSPHHSPRPSGLRRGRSRSKFEVGEPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V511</accession>
    <name>K1V511_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_06610</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V511"/>
    <dbReference type="FunCoup" id="K1V511">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V511"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015120_0_0_1"/>
    <dbReference type="InParanoid" id="K1V511"/>
    <dbReference type="OMA" id="WNNTIGA"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="124"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="17">
        <location>
            <begin position="380"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC99069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="828" mass="91791" checksum="8599D370650E75C0" modified="2012-11-28" version="1">MALAPPHRHRPSLPLLRPPLLPPRAPAPCPSEEIVMRHVQALENCGYRTVGTEEAVLGEQYVEKQVREIADRCHKNGVLDCEVWVQKGSGYHSFSIMSHDVLKLYAGIANIVLKISAKEPPSGKPEGRQDAVLLNAHIDSTLPSPGAADDGIGVGVMLDLARVLVDRNQPFDNAIIFLWNGAEETLQDGSHLYSTQQETAPEVRAMINLEAAGTTGGALLFQATSKEMIEAFSHSPYPRGTVIAADVFSSGIILSDTDFGQFEEYLGVSGLDMAIVGHSYYYHTRKDITANIERGSGQHFSSNVMAIVDYLLSPASPLHSDKPFSPPDVVYMSLYDRLFFSWTMKSADFAYVAIATAVVTLAAACVRRDRLQAFGLSLLAAPLSLLHGFITTNVAAAAMQASGNRSAWFSHEGLAVALYFPAGLWGYCFTQFGLDTFVPPEEADYLQTAHYYAQLLALTAYMLILQALRVRSAYLFAGLSCILLLGATATEAYKYFGGRSVRTSFAIAYIVPLSLLVILGMEAFTTTLDIFIPLAGRMGKEAPTEFLVATIASGCGLLFFPLASPLYARLTRFGQFKVLMLLMLTVVSIGTYFSLPTWKAYDAQHPKRMGVQYTYNHTSDEHTAHFAFMDMRGNTEVIETFHKRYGGQTKLEHTQVDDYNSDWDTLYPVSSFLDTYKFPLPYVGFDWPKLHHTSERERTPDGNLHIRIKMDHEGLVWPALAFEADLVDWSYDFAPPHGRQRHHIKAATSVDEHTIELELVVRIPDEEKIQLHWSAIDLNQMVPGTASKRGPNMPASKWLTEMDKWSKKKYDGSLDICMNGVVCGVIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5E5</accession>
    <name>K1V5E5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5E5"/>
    <dbReference type="STRING" id="1220162.K1V5E5"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="InParanoid" id="K1V5E5"/>
    <dbReference type="OMA" id="CLNREFM"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="206"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40146" checksum="FBE231B7FF84EC18" modified="2012-11-28" version="1">MTIGSMPETMRAVAFVEPNKVEVVERPTPKIEAESDIILKTITAGLCGSDLHFYRGHLPLKPGSTVGHEVVGQVIQVGKDVTKFKVGDKVVVPFSTNCGKDTCFYCSKGQTSRCPEGLVFGVGQGLEGCQAEYVRVPQADGFVFPHPNVPSTTALLLADILPTGYFVAAGGKRLMLEGEGRASTGDLVKDVEGKKEGVCVVVGCGPVGLCAISSAVRMFDKVFATDLAPSRLEQAKQHGAIALPLEELKVELEKATDGRGADVALEVVGHSDPLTTAIDLVRPFGIVSSCGVHSEMFTTHAYMLYKKNLRFQFGQCSVPTYFKGAVGVIEDNNELFSKFIQHKIKLDDAPEYYTQFAANKIGKTAFVFDEATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8E1</accession>
    <name>K1V8E1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8E1"/>
    <dbReference type="HOGENOM" id="CLU_909695_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8E1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="306" mass="34188" checksum="EE72002503713B61" modified="2012-11-28" version="1">MKDRERKRAKLSTLEIRGDGGAVLSQRVRSDLRVRELLASWAAYLERHDSNIAIDVQRIECNGQALDADERLFNVPGCQHGHIALQAARKPQQEQTATEIRTHVTVTVETVRRAYAQRLGVKPESFWRVPTYMQVGQLIEDDPEKLFFETQYTTDRCNAHPVSSGCVGQPAGRELQAHEVVEKLTGFSEPVELTASRKAPSSISASPRLSLPSGARCKLIPDVLGSTPVPSHGQSRPVLIKARSCTTAGQLKMCLAEQLQLKSLDFRLWHDTDVWWSGSLGNLLGPYDYEEDEDVIIELKPEQYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8K4</accession>
    <name>K1V8K4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247308_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8K4"/>
    <dbReference type="OrthoDB" id="10688251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1530" mass="167183" checksum="6A603EC35D4FD638" modified="2012-11-28" version="1">MERFRARFPAPKVEVIIAEALECERPEDPAYLRYAGMAGSSTPGQRARDDEQTEEASTPRAQAATTARALICMRPSARSLPSSPTTSPTVATMPSYPADGSIALNDATGQVLLTRVRRLNTLRQKAAAKMLQEESSFYSFINGLRNAQGDRAVHDGDLGLALDLGKLALAPLHAPLPAWATPDNDADLSDAAGSFVQHYVRQLTWSTCSLFVADMKRFRCRYPAPKVAVLIEEAQEHPQLPVHLRYFGTTGMSTPGGRAHDDEQGGNDTFWLNLLRETGKAADVFRLNGEQTLRRSARSLPRLRPYAATRRAAVTAMNPTSSPSTTASLEKLNADIETLLRDDKDYWEGERGVEPMSKAAFESVLTSARVTRLVAGGVSHLRVAKDVTEEAFRSDDGRLGYFGQHAGPGPVVSRAVVRAMYNGDGADEDQTAENQGHSAGPAPLPSPDRVAAVTALAAAHPSISARYPADGSIELDDAVGQKLLERVRRLDTARKATATKQLKGDRNFEAFVNVLRAEQGDRRVGAGDLHLQQASDLLCLALAPLHAPLPSWAVRTDEAELNKDVGTTARHYVRQAFWPSSAEFIADMERFMRLFPAPKLLVMIDKANERPTLPVHMRYFGTTVMNTPDGRADADEKKSGSFWTNVLSTTKRPVEVFLLQDYRTRSDLHATERALIAAVAPLCGNSARGGFHHEPELAHFGTVKLPAFDDPNDPATIQALQRINADAEKISQAAFQCALDSARVTQLVAGGVAHVHVGKDVTQEAFRNEDPRLGYFGQHAGPGPTVSRAVVAGLIDEPRDEPRDAELLGMGAFFDLWIWLIHWLIRLGLVLAMRHLSILEPLVVVAESREVTDRLLLAGPFLGDLPVPGAWPTEEELGAVVDATLPFGGLPWSMCQGRPFIARCGIGKFCLLVPVGHGGRVKYDPVVESELVRVLALSNKAALMAVSVAMEFTRERGRPDSGNLACWQELLELIKNELVVMAIQGELEDAQEQLRETGDWVWSRRRASALQRKSAKARRGAAKEPMTVDEIMTTWTRATRTTSISTAPTPTPLRSQPHQGCEPELSSASKGPSGTPSAAPVRPLRRLAGRLDDLRARGVDEDLFPNMLSPPTATTREAWHDVFLGGRPFQRVRVSMGRRSKGVPEQRRKIEKPRQGVGAYDDYGSRVCPSMVSASLTPAILADSSIVPDDPKRWRCIVNACPRIVQLGTEASLDARGVKLGGCVVCLEFAVVKLNPKQTVGQDDHDFDDFDDYDAGDVDHLDVEESGAGVEEPLQPELRTRTVIKYEGPKGDSPLRKQFGHLSSWLDDLRARGIDERLFPNAGRVGLAGAQPPTAPRRASSPWLLRSLRPLPRESDRRSLYHNWGHFCNGKPPGQVAGVEYREGCWVSRLFFASESYRFPALQDEVDEAVEYHDLEDVLETVFDESSPLNWLAELVPPGFVVPSDAPPVMVAKDSTAEWLALNGVALANRFTLGAFSELEETRTDNKGSSKAIAKAVRTARTGRLTLASTRATFPAATMPYSTASPAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAM8</accession>
    <name>K1VAM8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAM8"/>
    <dbReference type="STRING" id="1220162.K1VAM8"/>
    <dbReference type="eggNOG" id="ENOG502SGEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012804_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAM8"/>
    <dbReference type="OMA" id="GEVAFYF"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="561"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="635" mass="68096" checksum="94DAB2CA5A7BB654" modified="2012-11-28" version="1">MGKKKSKKDAKDAPPAPEPLDYPLLDPSLIFAILLDYDPSELGRNEQAIRDQLGVLEATSVPDNDDSNGRVETDTPTYSESSSALLSQTQTTSITDNTETFDDEDPQDEIDFLKAFFPNLMGHWPDEPSSESDGGAFRPALSRRSSRSPTKKAAVLPPTGKKKKKPTVTIPVVDTMQRRSASGRSTPVTPANSAGVIPATSTDVWTAYASLTETLAEIVPRATPGYFKSYLHSGDYDSAHEATLAALNALAASNARLGEDLADEAWQIFEDVYGVSRDDGNNDISDALHACIGAAEGDVMSVMDLMNVVHDLRFWPDYEARREAEQDPFATLSALERQLPKSAGTTSPPKTTRVLNGNRLTRPVSEPPQQRTKQTEQRVGNGNIREAKVRAVPGSKAPAGSASTSTSTSTSTSVSGASTPVRTSPPRARNMPATYTQGFAPSPVAWTTVNSKKPKRGPHPLSANIPAYARGAPAPSLAAKDPEELTPAECYARGAAARRAREDAMRAAGRHFRSGQKHIQASVAGHYAAQAREAATAAREWELRGARLLVDEQLESRPATIDLHYMSVEQAVTIAKETASRHHSGGDGGTLIIITGKGIHSAGNRGVLGPAVQRALTAEGYRVTRQEGYLAVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB40</accession>
    <name>K1VB40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB40"/>
    <dbReference type="FunCoup" id="K1VB40">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VB40"/>
    <dbReference type="eggNOG" id="ENOG502QT50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079101_1_0_1"/>
    <dbReference type="InParanoid" id="K1VB40"/>
    <dbReference type="OMA" id="NEGSHAY"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="118"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="29283" checksum="EE080F885AD8942C" modified="2012-11-28" version="1">MPAPVANPESETRYLDSRPASILSRTSADIQAGRQQDAYMKEVVTEAVKGALVGAAAFVPANWALKRRFPYYRNLPLQGKAFLGLLFVVPCGTVFAEKAGEHFIARNQWQGAGKDELDKEARLAEQRWQGLSTTDKLKDWAARHQYSIIGGSWVASMALAFGIVARDRYQTFPQKIVQARMWAQGLTVAVLVASAVAAGVNAKGEKPKKPVDHSWQDMLDMNGSLTKAERIQLHAARKAGEKMQKEEQKEEHEHASSASSDKAHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBV4</accession>
    <name>K1VBV4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07299</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBV4"/>
    <dbReference type="FunCoup" id="K1VBV4">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBV4"/>
    <dbReference type="eggNOG" id="KOG1962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087648_0_1_1"/>
    <dbReference type="InParanoid" id="K1VBV4"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="181"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="25534" checksum="903DB345AC01E35B" modified="2012-11-28" version="1">MFHFLAENPAVAKVQYALKITFIFVAVLFIDALQRMVRIAQEGAVAKRNPEVAADVRTETTYVTVSSVTWGGSDLVTDQRTAIATGVAVPAVVFLRGAAEDRGVTIRSPTRGPAITPLPFCEVPADIPVYLTGTTLFLSLVLSRVFYILLDFIQTQEELTTLKGSTAKGSTNAGENAELRKKIKVLQAELETVQSDADRDLSTLKKQANQQAAEYNRLADEHNASTGAVSDKKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCI9</accession>
    <name>K1VCI9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCI9"/>
    <dbReference type="STRING" id="1220162.K1VCI9"/>
    <dbReference type="HOGENOM" id="CLU_536583_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCI9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55144" checksum="0A9B0F0A04C22C9C" modified="2012-11-28" version="1">MSSSVVLAGGQVHVHLACSECSSTAWSHQQIATLAEQIAQRVASLPGRSATPIQLKPEVPGPSMRETPTPSLGKNGPRTRTGCFTCRGKRVKCDEAKLNVRPTKPGARARSDRVLAKLWEAQMFVSASGEFNPAAAGRQATGHAALANALVSATRSLGAVKRAFSQMKPTAVHAEMFAASRQLASDAASVIVGAIRGTALNDPETMCILFELFLMRDVSEALCIETDAQCASGDPEWNKTHQLLREYLIHTGGPQRLLENDRAALLGNSILEDHLVYLTVYDTFAALTTNVEPLMLAPGHTRWIEDVTCAQQVVHADFGFSLKILSTVAQLATLLAHKPYGTPGSIASDAESDGAYVRACRALNEELETDTLATIYSTTAPTRVQFGDLLIRHALICHLRRIALGRSRDDERIQASAAAIVELLVEVSVRTGSMINLNYPIIVAAGLIPPEERERMQTIIDFVRLTSCLQEVYRMEEVRSIWFTRNLADEARLCTTAGGGWRMARTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDD2</accession>
    <name>K1VDD2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDD2"/>
    <dbReference type="STRING" id="1220162.K1VDD2"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_1_1_1"/>
    <dbReference type="InParanoid" id="K1VDD2"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="23368" checksum="B67565308AE22988" modified="2012-11-28" version="1">MLPRLHCLRLAYPSARRYLSATLAQPAPAPRFARSLTEDQKNRLEKWRMSLTPSYRYINADANPTGNGREYAVVDVRDSDFAVSPLGPPPSTFSLHLATSVHAALPDGRDPAMGGNIVGCLHYPSDEFMGNITEIVDRVKSGKLDWRNVRGPKAARRYIEARDMLLKEDAPKDQEVLVLREGFEGFHPRYRDDPVLVEKFNKFYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDM4</accession>
    <name>K1VDM4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDM4"/>
    <dbReference type="STRING" id="1220162.K1VDM4"/>
    <dbReference type="eggNOG" id="KOG0652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336217_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDM4"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="223"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="848" mass="93760" checksum="628374C7FF59AB56" modified="2012-11-28" version="1">MSAPAGEPPVPPNQPSNNDRKEESPSSPGQATEQAAAGEDVKMKEAKPEKPEETWDDIPEHVLKGDAQEIRMQTRMIDNEVKMLRAENLRLSHEREQMVEKIQDNMTKIKQNKVLPYLVSKVVEILDVDAEAQEGAAHNEQNAKKSKCAVIKTSTRQLTPGDLIGVNKDSYLVLDKLPAEYDARVKAMEVDERPTETYTDIGGLDKQIEELQAEKFKTLGIKPPKGCLMYGPPGTGKTLLARACAAQTNACYLKLAGPSLVQMYIGDGAKLVRDAFELAKQKAPAIIFIDELDAVGTKRFDSNKAGDREVQRTMLELLNQLDGFSSDERIKVIAATNRIDILDPALLRSGRLDRKIEFPLPNESARERILQIHARKLNHKGVNFEELARSTEDMNGAQLKAVCVEAGMNATQLSHEHFMGGILEVQARKAKEHHTAFRPGASSTLHCPLVCTSAIRTSSRLHTADFREQGFSGQELKSRVEAGGWEPWVSYWTDSTAPPATGTDVFELEGPLEDLYNRLEGVSDPFEDDGTDKAAVKALLDEVWANSKAKNREAPEPQSAKTLAGMLSKRIRHPITYMPALLGMMGPELITVYKASLAGQRISHTDAYDMFIDMSDVLSVLGDIDVRSLDKFQSPPPILQCQPEVGKKPSTRVVTYSFADLGLYRSLVLLDQSPRGVRATTVGFTATNRSGGMWLVVFELLESMWHLCVGVCDFALGRGRVGIQLEDSEDARLLRDADVHSLLDNYDDEDDNAVSTEPDDGSIPDDTARRGRLILDQFHHNAYHLYARLISVSAGSWELTPAQLKELTGRWTGGNEEERQWLALARNWNVEPAIGSENTEGGASVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE40</accession>
    <name>K1VE40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE40"/>
    <dbReference type="STRING" id="1220162.K1VE40"/>
    <dbReference type="eggNOG" id="ENOG502SHBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008244_1_0_1"/>
    <dbReference type="InParanoid" id="K1VE40"/>
    <dbReference type="OMA" id="GNNTAHV"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="266"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="692" mass="74638" checksum="FC009D4AC64CB39A" modified="2012-11-28" version="1">MEQPSELDPLGAQNMLFAQTQPPPPSALLSSPGRLFPLLNDNNASANLATDPLASSSSTSSIDTARKQARRKAAPYSNAGPRPGVERATTATSSASNADGTEEDSNDPPTSNPRKSRGGGVAQTLTTCRKGKRRCEPSPLVPPDHPDVAKLPCARCRRFALDCVRMRVSRRKGPAPVAISDAAHGYTQAAASVLEPTIIDPTKTATSSTVQASPLNFDVNSLAATGLPSPSYPLLAGSSPSTWTDNAAIPTSLDQVVAPAVMDNIIGLFFDYVYPLTPALHRPSFMADLAARRDKSDPVFFALALVVLASTLVQVPRVLISLDKEEVEQLARRCVRVARAKTAFIWDDSVPMRAEFVVIFYLEGIVHLLLGNNTAHVISTAQANQCALALRLNEESNLNPIESEVRRRIYWLLFQADKSTACLRARTICLRLEDAQGLRLPSEVDDEQITAAGILPQPVGQTPLITGFNVVTNLFRILNDALLLQRRKAPPNVDSILADLQNVNQLRDRTVNATTEVASPLKSRSAFDSRAASPAKGWEANLQARFMDFFQTASDSSHVNSFMVMQGNILVTQQVVRLVLLQTREALLTQLAALTQMPLQGVGGLAGVQNSEVAEDIACDLLDGLNSLPEECLATNGPSLVQKVRFVAIQLMECSTSSRPQAVRAQSLLMQFLSVLGVIEGMYTFGRDVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEK1</accession>
    <name>K1VEK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEK1"/>
    <dbReference type="STRING" id="1220162.K1VEK1"/>
    <dbReference type="eggNOG" id="ENOG502SFU2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826882_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEK1"/>
    <dbReference type="OMA" id="TESAPIN"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="36416" checksum="CF9A93AD6867B5C9" modified="2012-11-28" version="1">MLRRRLSAGALRATAQLHTAAPVAAAPKRNSNSVTPAAAAARANIQPATQSKSLASAVLLNTQRNWKNEKVVTLKAELKRRNLSQQGNKATLVARLHSADTTGMLPPVPPVKTPGAKQSRRSVSTSRPAFEEPKPGDVAHTSGDAPEVAASHPGLPIKEKTESAPINIKIPKHQDPKEDPQVIPYTPDNFQKPRSDAPQNQNQKSLHEQVYTPASTATHPGGGPLHSQKQASDTQLEPEMVWDESGKPVSKADRESLLTAAEVTELGGVPVSLPVWNTKDQIYEPINRPLDEGEKQGLWVLGLGFAGIVGLGYLDNKWSQKRKAEHKADADKKKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF79</accession>
    <name>K1VF79_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF79"/>
    <dbReference type="STRING" id="1220162.K1VF79"/>
    <dbReference type="eggNOG" id="KOG4595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1157087_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF79"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26313" checksum="5AD418CAF0E17605" modified="2012-11-28" version="1">MKDHPHPHLQPEDMGIEHPDAAEEDFMEHAVNLESRYQNPQTAEPGIQRTGTLRVQAPSQSADSRFYNEGYAAGHAHGKLHGLFEGRQLGLEKAWEIWEEVGFYEGFAAVAERKLATSGGSGRKDAKGRVGRTPSRREKFRADPRTQLHIKTLRELISQFPTTNPTPAGGEPVPEDEGPDLAALMSQIRARYRLLCTSVGARPRLVAVSKDGTDGALPSAGVVEGIEGPMKGVDTRQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFI0</accession>
    <name>K1VFI0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFI0"/>
    <dbReference type="eggNOG" id="ENOG502SEPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1046581_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFI0"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="29047" checksum="4F5845194BE34D50" modified="2012-11-28" version="1">MSFSSLLNLLKQADGDGPDPGSGSKPPGTAPSASTSASLPSRPSQPNSALSDLLAQLDDEPREPTRSAFDGPRKGLMEPFGPVAAMAAASQQRRASSSSAPDAQDKGKRKLDDTVSKADWSFSRCLPVLTDLLRDDEFVKELKKAEQDSLERRLWARMEKIKADHEAKTKPEREVARITRKPITQEKQNLTQALDEFYKGHVMTSVDGLAARHRSRLVELGVPGLGEGKAYVKGAIKTREDKEAALKEKERVKRIMGVLEGALEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFS8</accession>
    <name>K1VFS8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFS8"/>
    <dbReference type="FunCoup" id="K1VFS8">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFS8"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFS8"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000010">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="36134" checksum="6FB58F9AC160A4D3" modified="2012-11-28" version="1">MATNDAHANILTPSEAIPENAVHVKGPDLSNRIDLTSLLKAYETIGFQATGLARAIEVVDEMRENSEQPLTLFLGYTSNLISSGLREIILFLAKHKLVDALVTTAGGVEEDFVKCLGSTILGDFHLAGADLRKKGLNRIGNLLVPNSNYCSFEDWIMPILDQMVKEQEGEEKVKWTPSKVINRLGKEINNEESVYYWCWKADPAPLNVDIVGDIRRLNDMSVKAKQAGMIILGGGVCKHQIANAMLFVSSICKWTETNAQRNGADYAVYINTGQEYDGSDSGARPDEAVSWGKIRANAQSVKVYADATLVFPLIVASTFGKAHWEATGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFX8</accession>
    <name>K1VFX8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFX8"/>
    <dbReference type="HOGENOM" id="CLU_940694_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFX8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="32230" checksum="64EE2EEAA00451F0" modified="2012-11-28" version="1">MRDHPVKTPAEWPGVLKTPGATDWPGSLNPFEGEFALYDMLKFRSSVDYTASRKSSGVVPEEVASAVESLSNSGPSSSPSAQSDSTYRTPSTHRSTSTHHVSFASAGSSPTMETPTASSVLSAAPAKPFYKHPFAVPDPRGDPKVHERMELDRPHPFSLAEGIARSLSAPPPPAPPPPTRAPSIVSSIRSGRSRLGSRDDTDIHMEHMEQRRKAERDEFGKHHHHLDALLKAKRMSGRPPSGALWSGWEWVALLAIVEERFEHTLGARRSDNAVNELRSGQSDTVPQASAVQIQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGC8</accession>
    <name>K1VGC8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGC8"/>
    <dbReference type="FunCoup" id="K1VGC8">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGC8"/>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035888_1_1_1"/>
    <dbReference type="InParanoid" id="K1VGC8"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="466" mass="51950" checksum="C71B439BFDF42AE3" modified="2012-11-28" version="1">MPSTSKTAAKSKAGKTAKPYDRPAKGKGKEKAAPKLEDIGAPAQLSQTSRKGKKAWRKNVDIRPVEQALEAQRAEERLTGGSYSKKTDGDLFTIDTTGDVEVRRRQRVKKPLRSLAVLNEKSAMPSLTSRAVAPKKKPDVTAKEKARIRKIARRTVDDKTSADVRKTDLSTLRDAWGEEEEEEVELPADGFGVEGMVKPRVKAPQTIEEQRQQRLEIAAAQLAADLPVAGVSYNPAVEAHTKLIEAAAEEERKRLAAEEREAERLRLLGEVVASRRAIDTEISDTHVDGMTVGRGDGVDSDEDEESEDDEPALVKKPTKRKTQAQRNKAKRAKEAAQAQKDEARRKKLERAIPGAKSLGKSVEARQKAIEEAKRLRKLAKEKRERAGYAGGEKVGKFRVPEQAVPVQLGEDLAESLRQVKPEGNLFKDRFLALQRRALVEPRVPHLPKKRTLKVKEYEKHAYKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGP9</accession>
    <name>K1VGP9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGP9"/>
    <dbReference type="HOGENOM" id="CLU_064796_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGP9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="365" mass="39349" checksum="3A2B0D95F330F112" modified="2012-11-28" version="1">MQAVYLLESECTAGSAFFPKVRGRRPGQPDTGGAHVRAGSNLWTLARAPGHFHIINRATFDVATAGAVVAAFLAIVYLLLVVSKKATAQPEKKPIAVPVSARKSTPVVAEKVVVEEVKEVKPDSRPRTPLQAVGRSSATESKRHNVRIRRPRIAPAPQAPSLLPGFIPRTPRPFNAQRAESADAVPLPTPRSPTTSPTRSPDGKRSATNGETQRGRNGLCEPRFLPVHEGVRLGKPASPPRTVAPAKRPPVMRKHERPRFSFARPQKEGDKGGGGTYLRQLRHAGADTDGAPPRPTDTAAERASRNAGFDGDTFAPRVSALMGMPVTREHAGKHAGRELGVEQLLRMDLTGARGVRKRRRLTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGR9</accession>
    <name>K1VGR9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGR9"/>
    <dbReference type="FunCoup" id="K1VGR9">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGR9"/>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_1_0_1"/>
    <dbReference type="InParanoid" id="K1VGR9"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="162" mass="18027" checksum="E94EFB0762943337" modified="2012-11-28" version="1">MGRMYSKGKGISASALPYSRAPPSWLKTTPEEVADQIFKLARRGLSPSQIGVVLRDSQGIPQVKTVTGNKILRILKTNAFLVGTIADSPGLAPTIPEDLYHLVKKAVSVRKHLERNRGDKDAKFRMILIESRIHRLARYYIKKQQLPPTFKYEAATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGS0</accession>
    <name>K1VGS0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGS0"/>
    <dbReference type="STRING" id="1220162.K1VGS0"/>
    <dbReference type="HOGENOM" id="CLU_166320_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGS0"/>
    <dbReference type="OMA" id="NITRPHE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="75" mass="7675" checksum="C0523287AC4DEFC1" modified="2012-11-28" version="1">MTYVEVKTLPAFSPLISVEALPTIALVALLAAFALTFFVTTLSKAPAQELGVALLAAFLAGAGTVALFCTVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI44</accession>
    <name>K1VI44_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI44"/>
    <dbReference type="HOGENOM" id="CLU_345877_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI44"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="817" mass="89413" checksum="A10DE6793A7526D7" modified="2012-11-28" version="1">MPNVETLRLFVQYTDSGPTVHGPNEGQLCPTLCGFAPSAVVLRGMSLVFDDIPLEIWIPRVLDRMNRLILVLDPGPTGEQWRRHARTSQPTEMANAGIVSVLRALPNLDLTIVFNARPGEIWDSDCNPVIINALGHLLSSFAGTATIVNLESVTSHPKLDRQRQIQNLNYLQEVRYGLNRTIFERSSFSNAPQYLSMRAWLRRCRLSSKAVDSTENEWDTQSAWAIFPRYDRRFFEEERERLAMEARHQPHPPMAWVPPPVVEAQWAGSVWNTGQPTDGPPPGLIADPNRTGETSTLVLRPRPQDRVEPDDGPAPLFGLDAATLEALGFNPATVAAMDSQRRSLVEAIARGEAANLVRAARAARAEATDAAGRAGPSTSSGGGSSSRLNVDIEAYEATFAAMDPVTREMIQALVLEEPSSPRPRPHPPRNADQARGAPPDDDFSIDAAPDFGHVPQLEALHVETRKVIEALVRREAAEAGRERLAGSAERALPSRTRTDRPGPSTQGCGDDNRTEEADALASAGISSATLAAMDPSTAMLVTESALDEWRLPEEQRVRDAELAVQLSAPGVRTREEASEPSAALRPPAQAPSPTRPIGIPTAPAVEPRPTLVLRGFQVPAERPSQTEGDAPQVAAVSREPAAVDRVSARLAAASAALERWQAPRPRLSDARSRVRFVERSDPRHPGHGEWVYVSGSSRSKYWDVKPLVADDDPRHPLNDPNTSPLAVRWPAYVYATGSADSEEYTIGQAPLWDNYEVQEPDCNPDDPESIAKLEAEGLRVTSDPSPEVPVDEVQRFVVDGTWRPVRDYSHLDQATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI78</accession>
    <name>K1VI78_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI78"/>
    <dbReference type="HOGENOM" id="CLU_2308032_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI78"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="100" mass="11043" checksum="F3DCB4C83EF895BA" modified="2012-11-28" version="1">MPVIRAAEPRITPREGYNLASPQHPSSQYPELVSEHTLLPPVQSCVDRGTCQTEDNSGMDIVTDTRYRSGTAAARETPADRSREEHRADSLAPGGPRRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJD2</accession>
    <name>K1VJD2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional MarR family transcriptional regulator, N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJD2"/>
    <dbReference type="STRING" id="1220162.K1VJD2"/>
    <dbReference type="eggNOG" id="ENOG502S4C3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065219_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJD2"/>
    <dbReference type="OrthoDB" id="2583774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="179"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="340" mass="37749" checksum="0B335DAB4AE1FE54" modified="2012-11-28" version="1">MAIPNDMEEIHALRHFNRYYTQRISVLSPLHDADLTLADNRVLYELANPPGESTASAIGKRLDMDAGYLSRVLRKLESKGYARREQSPRDGRTTLLSLTDEGWTEYRALQERTNAEIGNMLAPLCAERREQLMQAMKTIESILDPVTAPVPATASAPTSPPAKRAKLSGTNGTEPKPEVELRDLRTGAGDLGWILSAHSELYWKEKGWNEEFERIVAKIVADFRPSDRERAWIATVNGERAGCIFLVASPGDRNFAKIRVLLVTPQARGCGLASRLVDACVSFARERGYAGIELETEAGLGPARRLYGSRGFNKVGEERSVAPNAFGVDEFVSEKWELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJL8</accession>
    <name>K1VJL8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJL8"/>
    <dbReference type="HOGENOM" id="CLU_1994212_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJL8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="125" mass="13969" checksum="8604CDE8DBC9D1A8" modified="2012-11-28" version="1">MTVPRLSTLTALDTLTQRQNQHTQPAMSQSNGTSANTPAEPGPRYTWIGFRFSRALTLRERRLLHIVIEDRHMLPVPDPAVKNAQAELWFYLGDTGGFDADQVCRGAMAWAAINVPDADCQYNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJW1</accession>
    <name>K1VJW1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heparinase II/III-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000327">
        <property type="protein sequence ID" value="EKD01041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJW1"/>
    <dbReference type="STRING" id="1220162.K1VJW1"/>
    <dbReference type="eggNOG" id="ENOG502QUTC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008982_1_0_1"/>
    <dbReference type="InParanoid" id="K1VJW1"/>
    <dbReference type="OMA" id="YWGYGTS"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="4">
        <location>
            <begin position="605"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="863" mass="92740" checksum="A8744713717F3740" modified="2012-11-28" version="1">MASTTNNNYYDSPYDTPGGSDVGTSLLPPHDKDPMSSSNPYAATGSEPAYAPKKRKSRKGWYILAAIIAICVIVGAVLGGVLGSRAANKNDDKNSSSASRANDNTNAAKDPSTNNGNSGSNDKTNNAGTANQGGDKGQAPAPDAGNTALPGMIQILTDDRLPHETVTGPNGEVYLPAQTDVYMLPVYATGTGTAGYAAPTNVAGKDDSWPSDNEQPSSGNLRSHPRLIAPQYKWDALKNGLKDKDPYFSFWDTVLMGNASTILNKGSVKYEMDGGPTGSGVLDIAREIKVRIKILGYAWKMTGDKKYADRAWKELSEGISNAADAGYSADPWNANGHFLDTAEYTAAYAIGYDWFSDAFLDDQKSQIRGWIVDHGLTPGQQAFAGQGQVQNWWKNDNIKGNWNCVCNSGLILGALAIKGEDNGISDSIIDSATKSAQAACFQAPHTDGTWAETNDYWYFGTTGAAEMLSALNTATGASVESLLGDNKDRWLNTALFHMHGQGMTSLFNYGDHGPNKFSATANVLVFLASTFNEPRYALYQRDHYDAADPWNMFWYDPTTDGAFWNGLEIDHHFSDPAGEWAAARSSWSDNSGTYWGIKGGSLLEHQTHGDLDMGDFVFDAMGQRWAGEYGSGQYLSPGYFSSEAPDSQRWLYFRKRTEGQNTIVIGGENQFSGAAAPTVKWGSSGTQQGAAPYLEVGSDDTAFWTMDMSAAYNGTSSVKRGIRFLNGRRQMLLQDEIGGAAGTIEWHVQTNASVELNGAEASLSLGGQKLTVKIINANPAGLQFSTKDAVSAVTPPAPDSAKGEKDGDPDNSPAKILVISAGDGVKDASFQTLWQPQWPDKKDGDDKEPANVPLDQWSVDSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK52</accession>
    <name>K1VK52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK52"/>
    <dbReference type="eggNOG" id="ENOG502S1EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="InParanoid" id="K1VK52"/>
    <dbReference type="OMA" id="IFRDVMA"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30017" checksum="ACA96E93B8E126DA" modified="2012-11-28" version="1">MASYESLAPASTDARDAKLVIREVLPGMVTFSLPFVSFEAARQANGQERFGWIPIGGRSTAIKLPEGLFVYVSHPLTTATQEALQKLGGPVKWLVTPDGEHGMNIKAWSEAFPDAKPIGVERFAREKPDVKWAGLFGAGGENKTYGFENEISLHNVSAHRNDELVAIHHPTGTLLEADLLFNLPPTEQYSRSHIPGWFRVLLGSGSSMSPGGTLHQKLAGGLFEDKEKAKREMAPIFEAKWDRIIPCHGDVIESGGKAKWNEIWGKYAPSVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK81</accession>
    <name>K1VK81_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK81"/>
    <dbReference type="HOGENOM" id="CLU_1961135_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK81"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="128" mass="14606" checksum="0420106CE6CF0157" modified="2012-11-28" version="1">MRATNTYLYRRNSRLVSLETLLSFLEIRKAIILEYLHQAAADCEAHLRQLQEDAHYTGCIPAVMQGVAGTIVVCGEALTSFGTPHGAERRVARACIDHIRDIESMLEELEDLRLELWAYVIDIYAQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKJ8</accession>
    <name>K1VKJ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Streptomycin biosynthesis protein StrI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000202">
        <property type="protein sequence ID" value="EKD04665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKJ8"/>
    <dbReference type="STRING" id="1220162.K1VKJ8"/>
    <dbReference type="eggNOG" id="ENOG502QQXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_4_2_1"/>
    <dbReference type="InParanoid" id="K1VKJ8"/>
    <dbReference type="OMA" id="LICERQT"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="439" mass="48198" checksum="21C05A3810F28038" modified="2012-11-28" version="1">MTIDTKPVTMIILGGGQRGVVYAKYAIDHPDRAKVVAVADPREARRKIFQRQHHLEDDMLFDDWKPIAERPKFADAVVVSVLDQLHAELVEVFSKLGYHILCEKPMATSIPDCVKMVKDVEQAPEPIIFGVGHVLRYSPYNRLVKEVLDSGAIGDIVNIQHMEPVGNQHFAHSFVRGNWNKEHETTFALMSKCCHDLDILSFYVSGLKPSRVQSFGSIGLFKKSRKPREAGAATRCLECPAEKDCIWSAKKIYVDPFEPGSTGRKGWAAVMLDNTDLTLENAKEALKTSPYGVCVYEAGNDVVDHQTVNIEYEGGITATMTMSAFTEAECARSTIIQGTKGELIGDMRSFTVFDFLTRTKKTYTPQSGIGSHGGGDGGLSAAFVDAILAGDQAPLGITPQDVLNSHLIVFAAEKARRDGTVVDFDSFKEQALSGKIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKS2</accession>
    <name>K1VKS2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKS2"/>
    <dbReference type="STRING" id="1220162.K1VKS2"/>
    <dbReference type="eggNOG" id="ENOG502S4G4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364844_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKS2"/>
    <dbReference type="OMA" id="QMMDELM"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="36"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="807" mass="87379" checksum="9AFA52EBF316F313" modified="2012-11-28" version="1">MSEGIPSTLLRHFDVSAPYPRAEDISTRRPTYPQGQLFFDRLLALADTNTPSTDWASLYPPTSPSAQRKLLQAIHELPVDRLKRDCFIYYLLKDLDNNSALDMDVDGSRAASPSTPSSKAAQWARRRCIPRAWRTLMDGYWALDHGEWALAVEALTDPAIFDVNFLPDIVAALVTLVSAPQALELVHTLLSVRPPSSQDAADAALLAAANFGMLTAFTRIRAQAPGERARSREAVWCWALGAPRSPAGAGAHTAQPRALKELLHLVLSDEEHAHLVHFLAHPPRDIPAPARSLLHDLVTLRLIHAGKYEETLALDKELSESGADRQRRREMVREFIDILPAAQRRILLGDQGEKDWVVVEAEDSEPQQSQQEAPKALPAPAQEPAKPAESSTPAPIAAPTPVRPSLATRVLGTPQRPGSGFGGPPRFAESPRLAPPSTAASVVGGSAAPPSVSGSQRSASMRSPSPPASPPRRTSPTMVASPFHPPVTSRPAPAKKQPKRILDDEGPSRRSARASATPARSTPLRASRRSPSPTPTASEMDVDEHSGDETEKEGTPQPLLIEDEPEPLLIKDAPTPKLIEDGDEDMSDVEDEKPRLRRSTRRSEPPEERPSGRYNLRARARAEAPVAPCRQARRAAEALHARFLACFHRRARRARGGGDAPAAHPGAFEPEPKKTTKAKSAKKATVTKTTKAKTSKAAAAKDADEKESKEDKETASARRSAAKAALDDPEDKGATRGKARPKRTTRAQSVASSVADEDEEATPRRTRRTAASERGSPTPSVASSTASPTRRRTRAAAPTTRVTRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL04</accession>
    <name>K1VL04_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL04"/>
    <dbReference type="HOGENOM" id="CLU_1760076_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL04"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852220" evidence="1">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="148" mass="15006" checksum="6BDE9678F801C897" modified="2012-11-28" version="1">MLAATLFSVLSAVAAATPTLLTRAPFPVDAIPDVCSTPCETYKSVFSPDASADARATACQGGVFEQFNICMNCTSIEGVPNGMTSEQVQLLSLAVQQMGQECIESHYTSQYAGEIPAPTSLPKSSSAGSAGASLSAALVAVGALALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN32</accession>
    <name>K1VN32_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN32"/>
    <dbReference type="STRING" id="1220162.K1VN32"/>
    <dbReference type="eggNOG" id="ENOG502R0U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037789_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN32"/>
    <dbReference type="OMA" id="TKHESHT"/>
    <dbReference type="OrthoDB" id="3251871at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="539" mass="58900" checksum="E094C03659289506" modified="2012-11-28" version="1">MADISVNFIWTCIAINLMLTVVFQINPIILKLERWYIGLSTAIGFFIPIIPAALGHFGWDPLIDVWLVLDIYLWQLLSCVVATVCVGAGRATSRAMFGGDSINHLSLSDPHSEEETKTTRHHFSLVRLISKRRRSDHERAFGHLEDRFIRIALRVSLYPLAMIVVNTLIAAGDLFITVNGVTTTPGYALYCVYYWFYGGRGMVFCCLALFVDPCLSKGVYAAWQAKFPTKHESHTPEAKEPWGSECAAPGPVNTLDNAPVATVLDSFGGDGVAAPQNSLQRQESGGSMDMLQALFASEPPHVIEEQRRAEAKAVRDAARAARRQSRRSSVVTFWRRGSRDVEIPPITPSQPAPPSLPKSSPPTESPGEMEFAGVDAAFLPAEFADLTDVVAPEALAAAAEEERERREQEEREAAERAAAAAAAERAKELDRISEHSGASTPNLVTTLAYMARGRRASRVSAPAESIEGSGARSPNQGHGSPAFASYRSSAAQEWASGYGASRQSRTSAEGPRTPADGRSRRQRALEIAEKLYEEMEQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP46</accession>
    <name>K1VP46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP46"/>
    <dbReference type="HOGENOM" id="CLU_1171331_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP46"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="237" mass="24122" checksum="BDC3D4CA249A574B" modified="2012-11-28" version="1">MSPFPLIFGSGNVARNEPAAPRGLFGAAQINMVPRQDSAASADSAATAVPTESLASKGDSAEGGPETYWECDDPENPPDWAKGPDGQVTKRPVQCPSRTTVAVAADKTESVVPNDGKHYDPQHRTGTSTYVEATGSKSTTVPEDATAKDPLHRTGTSTVIDATGSKSTAVPEDATAVDPLHRTGTSTFAQATAATSQAAAASADAQKQDEKTTGSAAARKVGVAGVLAAVALSVVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPC7</accession>
    <name>K1VPC7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPC7"/>
    <dbReference type="FunCoup" id="K1VPC7">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPC7"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018004_1_0_1"/>
    <dbReference type="InParanoid" id="K1VPC7"/>
    <dbReference type="OMA" id="HHMIMTR"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="343" mass="37518" checksum="76A5462575522EFE" modified="2012-11-28" version="1">MSYVPVHERVNPPEYPTYADSMSDSERSVPEGPSKKRRREEHTPEVDGRHAAPTPPPASGSGSGSRTDHGAPEPAPPPPATSGISPSIFGIAPRNEVTRVVGDFIMRFGKGKPNLEIEVKLGTVCNPGPEKRRVRLPALSETLLPPDYPSTFSSTMSKQQHASINNLLNSAVQDSRGAVRFSREQHVDSLYPPPPGLLESIGHHGSHNDKVRVSTDRGGNVVGTIVKTRLADLNVYSPGECFDWRVSLSTETPVQFEPNSQPVNVREKDRAVYRADTCRVDLTVVTSRQGNKQPSLSYELEIEVLDAPGLIAEGEKEERGEPNVFDEVLQSVLDTARLIIRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPP7</accession>
    <name>K1VPP7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPP7"/>
    <dbReference type="STRING" id="1220162.K1VPP7"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005843_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPP7"/>
    <dbReference type="OMA" id="RTKAACW"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="2">
        <location>
            <begin position="483"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="909" mass="97946" checksum="E4A77D5424CB636C" modified="2012-11-28" version="1">MSDPKRLLAADPLSAGLGGKTHFAVAGQSSSGAPGDVRMYQWDSGTDTLSIVGLQSDVGGSIKALAWCPHPAQRRLLSLGLGTGRTQLFTLPQSSLNLTPGVSTSPVAVLSVKHQRAVTALDFSTHDPSLLAIGYERHRSDYSLLIWDIADAIAALPPDPSGESTYVRPSERLEAHVISRTDRCRHIQQYCASEAVHSVAWIPGSSFQLLASANNKAIRTYDLRTPSRDAGGSGAVTQWATKAVFHLAPRPGTCTVASAEMGTVRLWDTRQPGLEVTSIDVKDSGPVTGMSWVDGRLGVGTRDAGVRLWDMVGDEPQVAGMRHVVKPRQPLQSFAFVPSKKAKDIAFVVRDGTIGIGPIGSPTGVALSARSDLAICASGLQILDPETGGTGAWTPATSVPPSPVRETETRRNRFQLAPERVSALLSAQRKSRSGWSTPASLGRAATHEEALDELAHSLAVDFDEAQGMEGFARVLRHDGSFIMRRRVEEGYGLENLHLNAAIATRFPDADRIAGCWEFIDHFVRATGPSVSVRGSYDLTYQGLWAVWSGELGNESSAGWTGSMRSVSSSSEKGGPPAHDAEYNAAVAKLNALRSDAGSVGAPGSHRLPHGSRAPQRRMMLAICGENSGYDAMKEVDRLVADAQRTKAACWAFFAGEEEPAVTLLMRSSDERHRLMAATIAGFMTQAKAERGSLFWQEHWRSLVDKVDDPYVRAVLSKIAGENWDNILYDESLPLLDRVAIAVCNLTHAVPAQPAEPMRAAGLSPWPGPDGLHALGPRAATTFRRQNVRHSDGSPALRLLQPLAPVRLGRSPRPEMAGRLPLPSGQLAGVGRAVLLRRGSQGRAARARRGVADRRADHRHLPRVPQPDCARVQRTPQYQEGTLAWHRQAAERAHDAMPILPECAAEVLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPS8</accession>
    <name>K1VPS8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPS8"/>
    <dbReference type="STRING" id="1220162.K1VPS8"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_4_0_1"/>
    <dbReference type="InParanoid" id="K1VPS8"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="153" mass="16584" checksum="B26271B1F4518104" modified="2012-11-28" version="1">MSNSLDALKASGTTVVSDSGDFESIAAYKPQDATTNPSLILQAAKLPQYAPLIDSAIEYGNKASGDIDQKTDAALDALLVNFGTEILKIVPGRVSTEVDARFSFDTKATIDKARHLIELYKERGVDKERVLIKIASTWEGIQAARQLEQEGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQF9</accession>
    <name>K1VQF9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQF9"/>
    <dbReference type="HOGENOM" id="CLU_1961132_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQF9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="128" mass="13380" checksum="C0A0F96DA08F9D67" modified="2012-11-28" version="1">MPHRGKEQARAGMTCMTACQANVSSLPASRAWPNEVQPTRGVNGASERPNTPSAEFSAEFISKTLDAQPPPRTQVAQVQVGHGAASTSAIVSGWPSLSELPSRGDQAQAGPPGPPQPFGDPHTSRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQU9</accession>
    <name>K1VQU9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD03001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQU9"/>
    <dbReference type="STRING" id="1220162.K1VQU9"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1225522_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQU9"/>
    <dbReference type="OMA" id="CTPGEVE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="24610" checksum="B212F75A2B8EE3D4" modified="2012-11-28" version="1">MGYAKRAHLMNAMVPGLSGGKMSSSDAKSKIDFLDTPAEIKSKLKAALCTPGEVEGNGVLAFLKTVLIPVQELREEQARARGEERYKGEGSFAKADSPVGTLFSIPRPEKYGGDMHFSSYQALEDAYAKEELHPGDLKAGVTEALTSLLGPIRKVFDASPEWQEAEKLGYPNASVAAGAAPTKKEPKAKKPQKSNKPPTEEELIKLRAEKNQLYLKRHDLDTIPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRE7</accession>
    <name>K1VRE7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRE7"/>
    <dbReference type="HOGENOM" id="CLU_009687_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRE7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="731" mass="83322" checksum="E6D01268985D36B7" modified="2012-11-28" version="1">MVDLSAYGLGQFDLTPEDIFYVESPNCRGPLRHLKAGNPKPPRQRIWYPDNPPDHVFLAQVPCKQPVSVERIAAYPNNNILSGVAWDFTSRFVGDYRLRRNFHRVICTLVLKESHEASDFVSYTEQAQIDEDIWQFFGDRHLQTSLLLRNHFSLRMINTSHGTSFEEAFFSKLYQGIFDRDYRRWRKTHLRYREGPRRPSFLLVARSRLQSTSVLAECPVQMVAWPNVDINNLYAPYDKALWDSLKGQEKVDACDILLRDEADDEELDEYRRRWMEEGEIPPNTFFHLRPAEAEQVRRDAHMPYLRQKARKAFAAACANLLNLYDMCGSVYGTVIADRKFSRMYVLSRGRIAVELSNPRELVDLGLPVQGRFGLPYSQLRDMDLYEALSQRLTDDEPRPPPSPGRLFRWRFRGDQNVEPPEQNPTPSEEWGERRVTPDYGGLQSFIDFMAAGTTRLGALRADVPVTEKLPTPIQDRWDAEIDHCLMLRGLPLELATRIRTESTFPDGLESYLNFTNEEQARRPESKGLWRRAVRRWKAGMNPGWDPESSVEGSSEAESDDTGSDAGSSANGDEPLSDPENSAASHGTGSTESDVGEDGGSGDDVDGGHEDDSASVASTVYTARTKQWILETGSIKGTNARYSDWDVFDPDDLGLNEMNDRDDVAASEAGYSMCSAEADYYEEYHRVENDTCFVLSIAEQVLQEMCHVVPVTKEEMDELVQTQYALDLERYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRM8</accession>
    <name>K1VRM8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRM8"/>
    <dbReference type="STRING" id="1220162.K1VRM8"/>
    <dbReference type="eggNOG" id="ENOG502QW0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_2_1_1"/>
    <dbReference type="InParanoid" id="K1VRM8"/>
    <dbReference type="OMA" id="RKVTWWG"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="665" mass="72835" checksum="F63094EE80334146" modified="2012-11-28" version="1">MSASPPSPPRKRSNISQACRNCRHRKKKCDGQKPVCRTCQAYKADWRKNISRSEANALRARIAELESQLRQSRSRSPPSLSSSTFPGQADTTMWDSLVDVAITAGVQPVASHDAAPLPPPSVSSVPPQRSAPLPPSANPPPAPPEIGVPPSDLRNGIAASILPARRSPSADDLEGYIGRLRVHAPMSAFRHDSLPEPAQDATTPYEQTDDRTWARFLPDSLFFTRAQHDQAVDRFFRYAASWGQRATPHLFFRDMEIALSTPQESELPVVAPNYSPLLHNMILAVGLGFVDDEHLRALVTRRVFMQEGDRHLNRECANPSVATVQALAIRGSFMSTMGDYSIGWVNHGLANRLCYAPKGKLKPEAAVQRNVTFWSCYCQELPSGAHASLPSPRPDPATDDVMWIWPPGKYQSLPPQKSYLSLTFVHTTHLMQIASQISRTVYTGRAEKLSLVESGTVQRFCALPAPLTLDVNRSEPVLPHILSLHMGWAWVVALLYQPFSQVMPLHSHDGYQSIGTVALTLATLWDEQHSLRFTPPTTTAIIYCAGTCFLLAAAQAASPAQSTAAFQKVYAALAFLDKIGSTWGSGRRQAGILRDMLNECAKASMELPAVVGDLSRGWESSPTASFQCNTVQGDEEFDAFIQSLLSQSTAPLGEGDFMTGLEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRW0</accession>
    <name>K1VRW0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatase activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRW0"/>
    <dbReference type="FunCoup" id="K1VRW0">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRW0"/>
    <dbReference type="eggNOG" id="ENOG502RXS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028899_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRW0"/>
    <dbReference type="OMA" id="HKLLLFW"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36289" checksum="E30414071DE1C16E" modified="2012-11-28" version="1">MSAADASNPITSVASNPITSVAPGYAAPGIYSNQALLSRLNLDLRGRIFPVERETLMLLPESVLLGLFPQGLILSKPASWDGGDDGVFTVDFDPDCFQYILDFWADAQASFYGTPTSPGLFHAQQNMPPSPTSDPHADVSQNPLLTKQAIIVLREELEYFSITTPGAPERVDEHGLANEELRALKRAAGEALASKRQIFTALQRNVNKENNQAEQHLIDMLCMSGFNRDDEWGFRACEPNRNVISSMALVLLKTGIIHPGMEGAPADLTVPIIDDKQMGTAQKLLLFWRKPARKCWWDGVEVDVPVSDGSLRSVKCWARRVWTLELSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRZ2</accession>
    <name>K1VRZ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">rRNA processing-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRZ2"/>
    <dbReference type="eggNOG" id="KOG2321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254299_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRZ2"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1189"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="406"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="888"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1273"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="604"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1415" mass="154140" checksum="5CEFFE19D2F623E4" modified="2012-11-28" version="1">MSFPKVYTVNGPSSTSSASLPSWVTIKARPTRTSSGHKKRVKTQRELGQLELIQDFSFPSAAIKIRTTADGQHALGTGTYKPMIKCWDLGELTEKFTRVTDAENVDFVMLSTDWTKSLHLRRDRSLQLHTQGGLHHTVRLPIYGRALGYHSPSADALVACTGTEVFRFNLEEGRYMTPLNVASGWGNGMEDTVEGVNALDVNPVHGLWSFGLDGGGGVVEFWDPRSRTALTRLNLPATALLPAESDHNALYSAGTRLSVTSLKSHPTDGLSIAVGTSTGHTLLYDLRSPSPFAVKDQGYGESVRCVDWLRGGGQHEDSGRVISADSKVIKVWDKNEPARNHLSLHPPNPLVDLHCVPDSGLLFAACDASPINTYYIPDFGPAPRWASFLDNVTEEMADDPTSSTAYQDYKFVDRAELETLGLTHLIGTPALRPYMHGFFLALKLYQTARLIANPQSYAEHREKIVEERLAKKAESRIRAKREQPKVNKALAERLRKEQERLDAVEARKAAKRAERAAANGEAVEEEAAEGEGEGEGEGKKEKSRKDAVLLDPRFAEMFSNPDFEIDEGSKTFQLLNPATSHNARLRTAVEEEEDDSDRSSAGLSDEESEPESEPEQESEPEESDEDMDEDEEDEEQEDSGDGEEYSDASASEDEHEAKPKSAFPLARGARPKLQGATVSKPQTFGQRLHASRKPEKDEKPEGVLAMRRSADGGMEMSFIPKSGGSKGKLEDEDDEYGGGGYRRRSRVETFGAGLEKGGHEEEDEMQGRNGRTKRRHIERSASKNAFRRSSSSPSPEPPSLRNTPRSAFAPLPPVSNGHGNARDKKRSSSRSSHRRQSTSNGAPQRPPLRPDGPGWMSHYLGSASSAGGWMPESVDGDGFVFVKADDTEVEHQQKRRGSSSPNEARPASANGTHVRTGPPKKLPPDVTAHPVQARVTLLPSTVLGIRLNRKRCEDIILLSAVVFAIYKLAYGWGEWAVAGGELAACQKADFRTAHATHHQRRVRHPPRAHDSARRGRACPTKISGYRNGHPGQGEPALGAVCQRSVLCVPAQPGRQPELDHERCVDPGRRGSRERRVPRLRLWHRGEGIQPDTAVPPGWVIEQPLVNPSTPIRHITGVASSVSDATKALSALAISRRNAVQLFTLCSFVLLVQLSWSLRHELKRAKASVAAGEESSGTYWLKRGELRRNLAVIGFAFFVTACCLVVKAVTARIGHGVWSDMSPSDIVIATLFYQFCIYVCVRLARRGFTLGEMGIVTHAGTALFMETVNMTRTKTDPSLPHRVHQDVPPADATPHLPALAHPRLTSNRLPPVAPALPVPAAGAAAGPPPPLPARKGAAPPPPGARFLRRRGSDRNGCRGVVGVVVSRPPRPVAVDAAVPSPGPARVDPPRADQLLGAARALLGGGVAAPTQPRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSN1</accession>
    <name>K1VSN1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSN1"/>
    <dbReference type="eggNOG" id="ENOG502S1JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567639_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSN1"/>
    <dbReference type="OMA" id="QDAWING"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852426" description="Chitinase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="47856" checksum="F45016084BB62D1B" modified="2012-11-28" version="1">MISTLVSLLALSASGAAIDVSAPHYSLYLYDDVSAGSWPSADKVQPYNRLLLAFWESGGPTAASSSWASLPDDKRQSILNDYHDKGIAVMVSAFGAGDSVIGKKKDPVKLAQDLAGWVNQHGLDGVDVDLEDFDSLQNDKDYALDWLSKFYTELSNSLGGKPISSTPTAWMYGSAFGSADSVYCKLNSAVGDKISWYNMQLYNGAQGTWNNCDNTVKHSDNGAFLALGDISGMCGIPMNKMAVGKLWDKGELAHAGTEDQIMDPTALGQCLAGAGTGGVMVWSASLGSWDKPLNYLKDTLGAESSAPAAPAGNNLAVSASPAPSSVAVPALVSPSATSSDTPSAAPATDASSSVGSSSGAAAVSPSSAPGSASNVGGSSSASASAGSSSAVAGSSSAGASSSDAPQSASDASTSSGSNQAADPKAGQSDSKTAGSSTPDASKSSASGAAGASAAANKENSSASALSASFLVAAGAVLATLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSW4</accession>
    <name>K1VSW4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSW4"/>
    <dbReference type="STRING" id="1220162.K1VSW4"/>
    <dbReference type="HOGENOM" id="CLU_649220_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSW4"/>
    <dbReference type="OMA" id="PANPWPE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="423" mass="45810" checksum="195BE1D5E9D79C49" modified="2012-11-28" version="1">MTSGDRSPSPTWQFWPPYPKGGLQSTARTPSPPPAAPKSSSPCPECKSKKKAEEDNGFPDGWNGYGWEGDHVGRRPKPPPKAESEPEEKPEEPEEPEEEKKEQGIPAWAATDAPSPWPVPGPWMQPVAPLQMPNPTGFPVAYVQPPQWATPSYLTSSSYAPPQTPATPAYQQPPANPWPEPYQWMSDPRFAGVLAAMGQQPPPSQPMSPPPPGFMMGPHGMMPTMPFPPPAPSYPPHFFPPQHACNNPACVVHSPMAQATAPLLHPTPGPPPKAPTPSPAPTRTPSPPPWVPPWVKDPNWMWPNRFKPSPPPTPPRPPTPPPPPTPSPPPPPPPPPPQAHPRHAWLTPHLHDMWMALPPGGRPSRTLMGVMAEQGHVFPQGGAVHYEGYGGQAALGNGVQWVYAGPPAAPIDWTPYNVPMFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT15</accession>
    <name>K1VT15_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT15"/>
    <dbReference type="FunCoup" id="K1VT15">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT15"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_1_1"/>
    <dbReference type="InParanoid" id="K1VT15"/>
    <dbReference type="OMA" id="SQTRCVG"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8 9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="253"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="375"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="498" mass="53172" checksum="BA17689F3687912A" modified="2012-11-28" version="1">MAGQNPAYSAILNDLNRDVSREQPTDIIQFCADWFQDKLREERSGSTQAASPSSRKGPPGKLGPFGRPDIDSHPATLSPFSEHGPTDGPFGGPRRATIAAGAFGGSSSMFSSPFGGGGDRSVPPPANDSSPFSENAPSGPFGSNSPFGTGSPFGASAQTPSAPVGMPPPPQPEEDEDDDIHRDDEPVIPQYALGRRTSVSAESLVPAHARPFQPGVDAFIPEEEDEAPASMPVIPKSPEQLARIRAAIKPNFLFRNLDEEQEADVLAAMKKVKVGPGEIVIEQGAAGDYFYVVESGELEVYVKRDGEPGDGPRPDLGKKVAQYKEGGSAPRAASIVSITPCTLWALDRVSFRTILLDHTSRKRRLYESFLSTVPILSSLQPAERAKIADVLESRTFNAGEDVIREGEAGDEFFLIEAGSATALKTIDGKPTAVKDLRQGDYFGELALLNRQTRAATIRAAEKLVVAALGEQAFTRLLGPVKEIMARSAGERYGFAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU00</accession>
    <name>K1VU00_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_05491</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU00"/>
    <dbReference type="FunCoup" id="K1VU00">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU00"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_706342_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU00"/>
    <dbReference type="OMA" id="WFYHQLH"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012791050" description="Inactive metallocarboxypeptidase ECM14" evidence="14">
        <location>
            <begin position="16"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="154"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD00148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="391" mass="43928" checksum="BFA3650B942555F1" modified="2012-11-28" version="1">MRAFLLAFALPSVLAGFASDAGQGGQVPFVAGDTHNYRPTTQERYDGQSVKRFNLQGMSRDRRDMLVHVLNSFDLDIWRVGNATVDVRVPFALWNAVLSALPGNWDVSTMIPDVQELVEQTRPRPSLLAEPDEPGDPKHPPWDMNDILTPFHDEYHSFDDMLLFGNALVQAFPDLVTQTDLGTTEEGRPVRSWSIRAGQKKGEDDLPRYEFVVQSGQHAREWVGPSSALYLLHAIALDASHDPKGKWKELLRSYTFTVVPMINPDGYVYSHEHSRMWKKNRQEVGGLVCKEPFEAKETRIMGNYLQNGTADGERELPIKAFVDVHSYGQLCKHRGPDAILTIVMFPYAYSCEDFPADAENLMEAGLGAAKAMRMSEGQSYQTGQACDLTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUP0</accession>
    <name>K1VUP0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUP0"/>
    <dbReference type="HOGENOM" id="CLU_1112001_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUP0"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27765" checksum="C6E68E27BC903AD9" modified="2012-11-28" version="1">MPDAQSIVDDDHWKTGDVRITTAIHRLTNSPVFADMLSLPGMQSKSFEFADPTIEDAATVRSFLHLMRDLKLDMTICEVPSNRGTANARPWKHRLPRLVSFLDKYDSKFGLKALKHWSTYAELVEDWNPETTFVFGALTDNIHLCAKALVHPRSNCNWQDHPRDPLNCRAFHLFHMHGPPYEFVCSIPPQFYFALCRASADFVPGTVEFQKKFVEVVSAAMASTDPHHQVASAAFATHLHHDHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUQ8</accession>
    <name>K1VUQ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUQ8"/>
    <dbReference type="STRING" id="1220162.K1VUQ8"/>
    <dbReference type="eggNOG" id="ENOG502S4S4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1246124_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUQ8"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="222" mass="25261" checksum="6C0CC4DD4E552415" modified="2012-11-28" version="1">MSLVGTLRRFIGTRAASTVTAAQATPAAPPAPEAAPSIEELRQRAKRVYKEVSRLATDPSVWKASLLAVQATLLHRDASSTSCTSITITDHQLHRLGRDYPDENYNFNMRLRRAFEMVKPTQRSRSFCNARATVRPPTLVLSECVRNARSTSLTQLIRNRANGPENKNIDDPVKLKQQLELAEHIKKEILAMYSIRKYRGIRSRYYSHEAPRELPDHFHQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVK9</accession>
    <name>K1VVK9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVK9"/>
    <dbReference type="FunCoup" id="K1VVK9">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVK9"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010458_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVK9"/>
    <dbReference type="OMA" id="VYEWQSE"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000602">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000938">
        <property type="entry name" value="Probable periodic tryptophan protein PWP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="349"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="754"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="880" mass="96055" checksum="61DB287B2D6D9932" modified="2012-11-28" version="1">MKANYQFQNLCGTVYRQGNVVFTADGNSVLSPVGNRVSVFDLVNNKSRTLPFENRKNIACIALSPDGQVLLSVDLDGRAQLVHFRKGTVLHWMNFQRPVSCVQFSPDGKFFAVGLGNKIQVWRTPSHLAREFAPFVLHRDYVGHQDDVLSITWSKTGKYFLTTSRDMSARLWTLDPLEGFKPKSFGGHRDAVLGAWFSADEKTIYTVSRDGAVFVWGAKKAVGEDSDEEEEDILDLPSTSASAATVAEFEAAYTRWGIRSRHFFNQAGTKVACATFHQGTSLLIVGFSSGVFGLWEMPDFTPVHTLSISNEKISSVAVNPSGEWLAFGAAKLGQLLVWEWQSESYVLKQQGHYFDMNTLSFSPDGQHVATGGEDGKVKLWNAASGFCFVTFSEHSASVSSVQFAKSGSVLFSASLDGTVRAFDMVRYRNFRTFTSPTPVQFSSLAVDPSGEVVCAGSSDSFAIYMWSVQTGKLLDILEGHTAPVSGLSFSPNGDRLASCSWDRTLRLWGVYGRDRSTEPITLSGEATDVAYSPDGKELVASTLDGHLAFVDAGSGEIRSVIEGRRDLSGGRRAEDKMSAANNAASKYFTTVCWSADGRCVLAAGKSKYVLLYAAVDGVMLRKFTISDNLSLDGTQELLDSRKMTEAGNLDALDDAAADASDLEDRLDETLPGASRGDLSKRKYRRAVGANCVRFSATGRSWAAATTEGLLVYSLDESAAFDPFDLALDVTPESVLTSLAAGEHLVALILALRLNEAPLLMRVFEAVPPGDVPLLARQLPPVHLPRLLRFLAQHAEQGPHVEFDLVWSAALLTAHGRELKQRKAEFAPAMRALHKALMDFEGSVAKLSDQNSFALQYVIDQNRRAAGSQELGERENGDVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVW5</accession>
    <name>K1VVW5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVW5"/>
    <dbReference type="HOGENOM" id="CLU_438179_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVW5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049249">
        <property type="entry name" value="DUF6882"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21813">
        <property type="entry name" value="DUF6882"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="624" mass="67132" checksum="B8A388889890926A" modified="2012-11-28" version="1">MGCTSSKEAQVTTTTRTEKTEEGYKHITEKRTKHPGFFGGETVETITATIGGNPTLVGMIENGVQYDFSDGQALHDFAKGSCVRNSLQKFIIREACGVATGSFDMNTRTFTLGSYTFTCMLVGVLTVPSLNSARFTWGWAHPDWNEKVDAPVKRLQLMGEALNNKDLKSDAIIIDSPNDILPRAEQLGLDAANAAAQVLGHAMWVAFPMPDGQNLVAIADAEAAKPPLPADAFRKPNLGDLHTYFGEIWDSQPPATFNAGIVGLASSSGWVYETMSDGWSLSEPCTPPRRLVFKWDGSTNAAGKPQYEHTLYGVSPVTIDGVSYNLDLAYTIKANDVAEGQADTPAAAAAPGSTDCRQLIDFARDTFTYTVVRSDSWLKDASHYVGANDDQDLILAMDRPDLCRIAHVSKSGPNLLVPREVVATVNLNTRVLEWCWSDPATASPAANQIRSAGVDEWNSDLSTAKLTVAPGIDMEDVATAVSMAAAKATGLHVTASSTGSNGVVSIGLLRVHEVQAVPVEEVRLADVFHGFDSLWSMRSLFDLQGGANALAAKLGWTLTPLQAPLPGWILTEPASGSTFTFQDDHIKRETGDDYKIALDTKVAVSVNDGQLLNLNIHVDNSPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWB2</accession>
    <name>K1VWB2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWB2"/>
    <dbReference type="HOGENOM" id="CLU_1176134_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWB2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="26703" checksum="7E5E7D7BF3AD0D0A" modified="2012-11-28" version="1">MSDIKWHSNWPKQDNADGKVTVIANDGTHFMCDDFFLFEKNEKLKNLRKKADSGSVIEFDSADPLATPDNVHQLLTMEKTHRADLRDWYNLSPATLLGKLTSLVAFVQLIDFPESSYDDKRFYGRVSQRLSASLMVLLHGNYVPAGWVYALIGALDDPAEAVKIWMHKLGNGDKKSEPLSVNDLPAVMIPFIHRKYIAILLAYAQERQDPETAFFTMLKEYDDIASKGSVLLRVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWN6</accession>
    <name>K1VWN6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LAC2 isoform 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_00746</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Laccase that catalyzes the oxidation of certain aromatic compounds, including L-dopa, to quinones, which then polymerize to melanin. Able to oxidize a wide variety of aromatic diphenol and diamino groups in the ortho, meta, and para positions but not monophenolic groups such as in phenol, tyramine, or tyrosine. Plays an important role in virulence. Plays a role in dissemination to extrapulmonary sites but is not involved in pulmonary growth or in elicitation of cellular immune responses in the lung.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWN6"/>
    <dbReference type="STRING" id="1220162.K1VWN6"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_1_1"/>
    <dbReference type="InParanoid" id="K1VWN6"/>
    <dbReference type="OMA" id="CHFEAHI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13883">
        <property type="entry name" value="CuRO_2_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13904">
        <property type="entry name" value="CuRO_3_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="195"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="317"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="602"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD04946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="744" mass="80649" checksum="DBF75FF71B74426A" modified="2012-11-28" version="1">MRLSLIAFVGVVNALPQLMQSDASTGAPTISASIDSYSPSSSASGTVSPPPAPASSNVNAPSATGSPSLSLPDSVESSSLRAAASSLGALGASRATAAPTGYPTLTGGAPPTHPNTAPLPEVTGSQFYSMPLPVPFKGPAFPAWGAFFSYSQAPIPTQTIQVNPSIFTASLGTQEAINQPPQVREYEFNLTYAAGWPSGYLRRMAVINNHFPGPLIEANQGDLVRIRVRNGLDHPQAIHWHGIRQNGTNHMDGVPGISQCPIPPGGEFTYEWTTVNEVGTYWYHSHYGNTLADGLVGGIVIHSRDDPLKHGVDYDEDRVVYLSDWMNDQSEVIIAEEENMLKPYRGIPFVAEPDAALINGIGQCNCAGAQRGVPCGINEPAEIRMERGKRYRFRLINHGGQGLIRFSVDRHMLRVIEADDLPVKPLELTEIPVGSGQRYSVVVTADKGAPGDAFWMRARVGTYCINPLATVNGHGILRYTDSSGNVPVGMEGRQPETQQWSNLKIPNIALCRDLDEEEDLQPLVPNEVPGNARQSWVLDALFGVFVHPTKRTPMIGFGMNGIMYKNYINNPLLRRVMEGFSIGGRNEVAAVSFTADGGSADIVLNVLDPPPIGHPFHLHGHPFYIVARGPGRVSRFTLPFVRKKTRNAIKRDTLMVGQWSYAIIRIPLNTPGVWPLHCHIGWHLASGKMAAVAVGPEKIRGFKRPEEWEELCRGTDPGVIGPGRRSNVYEGWEKWAAVVNGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWV4</accession>
    <name>K1VWV4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWV4"/>
    <dbReference type="STRING" id="1220162.K1VWV4"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023733_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWV4"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="29403" checksum="94E3A6A114BB9C41" modified="2012-11-28" version="1">MGGVVARLAIRLAPDLPVDAIVSIATPHQLPPANLEFDMERLYQKVNTPAAIDPILISICGGVADTQIISDTCALPDFVGPDNGFTVFSSGVPAAWTNVEHQAIVWCDQVRWRIARILLDMSAATTRDEKLSSAKKWLREAPTLSITERHQVVETLPPVANENVTCIVRLRNPTPTLVAEPPLSLLSCDSSMICEQIAASAQVIPYPRDTRLPFPLPGEGIRNEESAFAISVYHADKDKTIAIASDEQLEILATGAHLQIRGTQGSWIGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXR1</accession>
    <name>K1VXR1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000136">
        <property type="protein sequence ID" value="EKD05336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXR1"/>
    <dbReference type="STRING" id="1220162.K1VXR1"/>
    <dbReference type="HOGENOM" id="CLU_1611976_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXR1"/>
    <dbReference type="OrthoDB" id="514292at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18754" checksum="8107D3135302F3A7" modified="2012-11-28" version="1">MKRRTSLALDAYASGSNPSNRHEASGTATPRPNSDAYAAGSSGTTGSSAADPAARGPDGGGGGSLGGPVEIVLNNPCAGEKYYQCVLAPVDEAEGRGRDLERLRAAFCNAFEESQPFYFPHLSLIYGDMDEDTRWKLADEAVAGGNWPSKTDFAEVVVVDINGYADQWKIVERYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXU2</accession>
    <name>K1VXU2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXU2"/>
    <dbReference type="STRING" id="1220162.K1VXU2"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_1_1"/>
    <dbReference type="InParanoid" id="K1VXU2"/>
    <dbReference type="OMA" id="NYERYTI"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06563">
        <property type="entry name" value="GH20_chitobiase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF57">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="6">
        <location>
            <begin position="13"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="406" mass="45503" checksum="91E932A6ADFF1393" modified="2012-11-28" version="1">MTACLLKPDGGAYAWRGVHLDPSRHFLPLDDVKRMIEALALLRMNVLHFHLSDDQGWRFESKKWPRLTSVASQRKQTVVGRPGNYGRGDLHPENYLNKYDGKQHGGFYTQDELRDLNTFAKSKGVTIVPEIDMPGHMKAARAAYPELGYNGTLLNVGDSWGVYPEVLRVDDPGLQFAKDVLTEICDVFDSPYIHIGGDECPKVEWAEAPTARKQVKKLGLDPDNLNSYHELQAAFTRELAKFLASKGRKLVGWDEILDGGKLDGVAVMAWRDWNDAARRATDAGVPVIQTPNLLYFDYAQGDEKSEPLSIGRGASLKDVYAFNPLKGVDKDKAGLVLGAQAQLWSEYIPDAKQLWYMAFPRLIALADVTYYGEKRVSYDEFLKKLPERVKELEKLGIVGHPLPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXY0</accession>
    <name>K1VXY0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXY0"/>
    <dbReference type="STRING" id="1220162.K1VXY0"/>
    <dbReference type="eggNOG" id="ENOG502QS8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012617_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXY0"/>
    <dbReference type="OMA" id="EMNIAWR"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="495"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="65652" checksum="127BF02BE0AFBAE3" modified="2012-11-28" version="1">MGTIDKGPCKIAAFSGYTGDRFDALKTQAESSGAPILFGDYLAEMNIAWRALEIKDDPKLGYERPFLAHLQIAAQAIAKNKCKVLTNAGALNPKGLAEAVVQLLASQNINLKVAWVEGDNIIDRLEELEGKGEKFTHLEGDGRALSGWGEKPLTANAYIGARGVHAALEAGADIVISGRCTDASPIVAAAAWWHGWKWDNYDALAGALVAGHCIECGAYVTGGNTSGFKSFKDNYHHFAMGIAEIASDGTFIITKQPNSNGFNGMVTDVTVRSQILYEIQGNGILDDITVTNVGPDRVEVTGIRGAAPPSTTKVAICAVAGYQAETMYFATGLDVTEKFDTIRLQIKKNLGDKVLSQFSTFDITQYGVAKENPENEALGTAMLYIFAQAKNKEAFGPVGSLTALVHREGLGHYPGMHTFMDSRIAQPKPYIEYWPGTVSQSHLPMTVRFVGSDEVIDVAPVGAQNETIAVIPQKDYDPSIKLRPGEYGSTTRTAIGHIVHARSGDKGGNANVGFFVPRNASGEYDWLRALLSKQTLIEMLGEEYKDNRIERVEFPGMLAVHFVIHDYLGKGVSSTARLDSLAKSVAEYLRAKWVDVPDKFLLRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXZ5</accession>
    <name>K1VXZ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXZ5"/>
    <dbReference type="STRING" id="1220162.K1VXZ5"/>
    <dbReference type="HOGENOM" id="CLU_1367103_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXZ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="19964" checksum="28B5360467B7E32F" modified="2012-11-28" version="1">MSSPSPSGVGSPSASPTTPLQTLAGLASRRSSAASVRGLGPLSPTLTLSPSTGPTRSFSQASPSSTATLTSPPQQAGLSPGGSSPGVSPRPALGRRMSRTAGMTLTAAGAALGSSYQAPLPVNASVASQLSLMGSTFLPDDEFGEGATVSINQPVGSLSISPSSRDVCLASRKGLYILDLANLEKAPRFIPQGGTWQIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY52</accession>
    <name>K1VY52_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY52"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_850430_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY52"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="327" mass="36660" checksum="70B52570584288AC" modified="2012-11-28" version="1">MSQAPTCPGELISHSLQSSEFEFEQEQDCHRLLSTEIRGREGRMFRSVGDSGITELGPSISRSVPSITLISGPTLMNVKKDAARFNHYGLHITQHYSAISSGHAVTNVVNFANATRVWIRNTGSCGRNESTLAECYDTSDGSPAAEKRKSDTLRDTWRPWIWQQCTEFGYFFGPAKEGGVLSKYLTYDVHHRVCRQSFPAGSKYQIPERPDTEKVNCHGGREINVERVLFTAGEQDPWRPAMPNAEGVNRPNTTSQAQYLMPGGGHCWDSQGYDAIDSGGGKDGNEPEPDLIRNTHNFQMGIVKAWLNDWKKPGRRSIEKRQRIRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY62</accession>
    <name>K1VY62_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY62"/>
    <dbReference type="STRING" id="1220162.K1VY62"/>
    <dbReference type="eggNOG" id="ENOG502QTIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_2_1_1"/>
    <dbReference type="InParanoid" id="K1VY62"/>
    <dbReference type="OMA" id="NDSHFAY"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF2">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="519" mass="57141" checksum="85F414218B5AA613" modified="2012-11-28" version="1">MAPVEDSPVLVEHPSYESTSSLAKAVPPGSDTKDVRLIESTEPQHQPVSQKLLKRYNIAYAVTTFGIQTIAFMAVGHHPGQPKGTGCPDTGAPCRVPFGKGDVNLTSLLLYLNAIAYGVSGVLTLLISGWGDHFSLCLPAAGLTAYNYANYTALIALYTIFSITGYLAMAWMNIFIPYTMYAAAPIDELSTQAKVDALAKTDDVEGETLRAKREREGLKMSVWGGVSMNVATVIFYCITIGISYAGATAARNAGMYMSTVAGGICIICALLGWRFLPSPGGKPYNGNFWMLPIRTFVELWHGLSRYRNAMLFLISYVIYNDSHFAYGSVIGTLFNLNARPSMTEFTAYSITGTATSIVGSLIFMYIFPYSRLSLRHWAMIAYSLTIFTTFWCCLGMSPSSKVGYKHRAEFYVFQVIMNLAGSIISPLFRVLFSEMFPRGNEIQYFGFQLVLSCGTTWIPQIANAPIVSATNNVRLPAVISLVFFIISFVLVWLVNDKEGVAIIRREEVAEAERHPEARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYP8</accession>
    <name>K1VYP8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein ureG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYP8"/>
    <dbReference type="FunCoup" id="K1VYP8">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYP8"/>
    <dbReference type="eggNOG" id="ENOG502QR6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072144_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYP8"/>
    <dbReference type="OMA" id="KMRGDKP"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="74"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="33839" checksum="B7B78F0069969274" modified="2012-11-28" version="1">MAQVCDFQNKLNTGNGDAAAAAHTHDGSGASHSHSHDAAAEHGHTHEHLENAGKYAERDMPDYSGRDWKERTFTVGIGGPVGSGKTALLLALCRALRDDYNIAAVTNDIFTREDQEFLIRNEALPKERIRAIETGGCPHAAIREDISANMHALEELQAEFDTELLFVESGGDNLAANYSRELADYIIYVVSRPMRGSLQYCATLEGGGEGSANVQIDVAGGDKVPRKGGPGISQSDLFIINKLDSSCHLADSQTDLAPHVGASLDVMRRDSAIMREKGPTLFTSVRKGEGVQDVVDAILGAWAASGAKGKNTPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYY1</accession>
    <name>K1VYY1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYY1"/>
    <dbReference type="FunCoup" id="K1VYY1">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYY1"/>
    <dbReference type="eggNOG" id="KOG1895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008962_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYY1"/>
    <dbReference type="OMA" id="NVRYGIM"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="120"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="849"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="685"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="116319" checksum="C49E113E8BDBB0DB" modified="2012-11-28" version="1">MSLYADDEDLYPSLPGSTVSAAPTDPLQALAAAVQATPETPEQADALQAAGTRFEDHPDKLPEVIEKLLPMVVEGPDSLLRAWTLDMLALTVGRAGLRTEVKMDELSSQSSRRFIPCSSGISKLYDVFQTSKARILSLVLDPGARPQNVGIKAAAWKYIQRVLLVGVRAGGDPRLQARSNDVSVALIQPGSLLNPAKIEEEANLLRTQLVTQLYGLDDPAILAPIINTFPPLVKQRPALAPLIVQSMAAWTPSAMEAARRPPMQIRSVEKTMRAVMAHIARHPPLVGFSAQLHDALGRQKQRMEMAYAADADARRQRRANMAAARAGKHPLESEAESSGSAAKRARMEVLLGSGDGKGSVMFDVSQLALEPVIDAVVAALGAASDDFLTRACEAGRQAILDDHPDAVQALAPALLRAEDREDAVVNPLEMLDDDDDELLLEPMEDELEQQVTIADFRLPPPEPLPETEKEEVVDFAVRRIWDTGADLSHLADLKISDAPRSAVQPREIWMLLLARISSRGGEDKRKLIGEFVAKDFSSRSKFATVWLNEEWLAKRRGRDNQYDAGLMAILTAYIPTLDAKDASLSQFLLGLPELPESAIDAIEPLCEDPERMIVGFRALKELAEARPPLRPRAVQTLLQFCTHPERKVRVMAITTVRSWVPNFPMSEAVVKYALGVLKRLATAKVREPPKPEPEEGEDGEKKPETEGEAAEETKPDVEMDTEAEPEPEPEQPEDPDAVQSKYLGEVDQDTVSQYVELPFALSRRDQDLLDDIFALYPKLAPSVQKSVETMLIPLIRSLGPTKKLLEILRTFPNGAERLAFRVVTVLSAEGSGQLLAPVVRQLMAERQVDPRFVIPIINVLDKAEIEAQIPRIVALLDSPEAEDEVRGAFAAALQKMTPADLLVTLHNEQAGLNATKAAIRICFTMTTVFRSDVLANAMQRIVDLHPEQGADALPKVFIRTIIQALKPYKSLVPFVANNIIPKLIGRKIWENPELWEGFSLLIRMLGQASFGALLQMPIEQIRQIIEKQPALKAPLKTFLANKPAARNSLAAIFEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ02</accession>
    <name>K1VZ02_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ02"/>
    <dbReference type="eggNOG" id="ENOG502S6ZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210536_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ02"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="229" mass="25081" checksum="ABA4B318D9964059" modified="2012-11-28" version="1">MDRIQQNPEELMRFANILASMGSMGSWQLGSWANGQMGVHGYSHLLATWPVRALYRQLSNQPSLASPPTAHGPNDHSSLTQAERGVGSIINLSFSSIIIGVYELMREASRAECQGRSLAPFLRSVADDSFGAGLIALELVPSADHYSAQIARYASFLHSFLGRGVFYLFLGVLMLNYYVILYVCGTAVAVVGLVYIALHFWAPFDPPSTMKPPSMDPEAQPVWQAPTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ63</accession>
    <name>K1VZ63_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000299">
        <property type="protein sequence ID" value="EKD02058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ63"/>
    <dbReference type="eggNOG" id="ENOG502RB9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298125_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ63"/>
    <dbReference type="OrthoDB" id="2564822at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34863">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34863:SF1">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1009" mass="109561" checksum="D9C6770EBCAD4154" modified="2012-11-28" version="1">MRTCAYQQQMNRFQAKYWQTAQVQQVMVSGVSPGSSPARSTTTSDLTSLSGDLSDPNDPSDPSDPSDPSDPSDPSDPSDLSDLSDLSDLSDLSDLMEEPSHSPSETGDSIVRASDCEIVCDSSSSCDSDIPATSDIEMVTQSDSESECATTTITVERASHSPSDNGDSIGRDRDCQKHSDSSSSCDSDNPASSDTEMLPQSGFEFQSDLDSGPEASQDSSNLGDANGSDSGSDSDSDSDSDSDSDSDSDSDSDFEPQSPSSGEELDYDERGSEMDHQTTSSSASASEVETGGPSPLLPFMTCFKAWSSLSQDERNNHLAGVRPQELDCDKWEVFMTPAEYLAQFNGPINTLTLASRVPKSNRVRKAVTSHRDDGLSDVTENSDSDAEGERAKILSSFFLLAKNGHLLWIDLQFKADFFKKLKVWRSVTPANNNLVGSYGALTVAVTQFVQALVAIGCDTIWLKGYGAKKPVTSFNDDCGGGHTLSHLNQWDFGVTYKSPSIWLFAPAEVSKVVTGYPMVIPGSLDFGSVKCDLPWDGHNYRVKVYPRLVHCIKSHNSRIQGERPRTFAGVRKRHQACDKVVHALSSDQSSDLGGFRIEVTVTAPTFMDACDKIQYFPFMRPSWWLSPKGPEGTEPGESLNCFKLDVKLVTKQGLLENARWVSQRASDKGLMAGNNSTAVTAQMRRVTCDILCSFGWNAGQGHITKSLSPSAWWLDSPVTEADQGVTVSLPSMSETSRASTTLSQLTSLFTGSPGVKRLRDLIKKLNNNVIPCPKGSVQDGHKLHSKGTSPVRFICALPPCKSHMNQAQAVKWFAELCDKGIISREGLGLPPLPQQHLATSNQQVTIRPTMRQDVLQPSPSPNVHPSPIPAGSSPRPHSQRAVTVTAPVCDRPLPKSTLRGVPVQYTIALANEPRAVTGGQKLYYSTWHPDDGNSMFAAFAKGLLLQGQQAHLVTRRAAVTTMRANPGVYRPWFLVNSMSQYLAVMSRPGTRGDNITLKALWENEVVTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZT8</accession>
    <name>K1VZT8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZT8"/>
    <dbReference type="STRING" id="1220162.K1VZT8"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636447_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZT8"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="367"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="431" mass="48552" checksum="AB41F01854B649B2" modified="2012-11-28" version="1">MVTSALLFFAGDSIAQFGIEGRSLPFTTKRDPAAIEEQAAVNELRQHEGVRAGLQGSGGVTAAAVIGEDGDDTKWDPYRAARLIFYGGTIFAPLAHNWLNLLQKVQLSTKFRTIATRVFLDQALWGPFVVGLFWSTNGILEGRSPADVYEKVKYAFLPVYSKSVMVFGPTAIISFTFVPLQHRLLVGQTVGLGWNTYISYLNHVNNKKLAAASRELESAHREEDGRETHTRTDEAERALKVARERREKLLSSQGGGSTGVGTQRYSRYYDAHRKSPPNFKVGDFVFLNRCNIVTTRPSLSLDQRMIGPIRIMRATRSPNAFVLDLPAALSHLHPVFNVELLEPVREGHPGQYQEPAPVVKLPEEAEYPVEEILRTRVNPDMNPTQGAAWEFLVKWEGYSSDDNTWEPYENVKLLKDHLRRFVEKQYMARFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W014</accession>
    <name>K1W014_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W014"/>
    <dbReference type="HOGENOM" id="CLU_477505_0_0_1"/>
    <dbReference type="InParanoid" id="K1W014"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="581" mass="64154" checksum="1690F994E65F2678" modified="2012-11-28" version="1">MKSCDALSDDSSEFHTAPSTPIDERSCPILESPAKIDPQVSATQTPADHPAGDNLSRSAAIESNFRGDYSCLFWLGGNFFTAEPEQIESESEPETLFDSDSEECAELNRRQRIAYLNAQSAAGTAYGPYHPNGIRGHRERIEHHGRWSPQLPPHLHRNGYSSDSGDENGSDSDDSGSGIIVCGDSHNPGAWGEVGDGLGNGRGRVGELWDGLGLDAPGLEPVERLGIRGQPGVRGGRARDGSGDAVYRGELPGADGRQAEARLGQGGAAAPSHGRGHERPRQGYSPMRWTDVHGTPAGYERQPTPGPSRQPYHPDDCDISRPIVVAPTPRDLVPSYHLTDGGASRAWERDQQQYSQSDVNLMYGLGLFPPTPPTRYPPAETEAPAPPRPRRHRVHRILNAVRRHVRRLDPHPPPTSFSASIDAHSRDILPAGAELQYKQDILTRMMKRVTLDAYRPHDTSPQTVQHVEKEYWDKVARGEMGITRPECVRNRADMAEFAHYLNRVENRIDMYVERGRYDPPPGGSRYEPPFEGRRDPPPARTRAPPRAPVQHPAFIPRHLRAQQVGTDSEDSDLEASCYARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0W2</accession>
    <name>K1W0W2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0W2"/>
    <dbReference type="eggNOG" id="ENOG502RY6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109157_0_1_1"/>
    <dbReference type="InParanoid" id="K1W0W2"/>
    <dbReference type="OrthoDB" id="2580091at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08357">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39434">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39434:SF1">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="140" mass="16126" checksum="0F7702F54495F7E8" modified="2012-11-28" version="1">MAAPRSLFHLAYHVRDLNVSRQFYKSVLGCREGRSTDTWVDFDFFGHQISLHLGEPFKMTNTGKVGDHMVPMPHLGVILEYPEWRSLADRLIDAKTEFVMEPQIRFEGQPGEQYTMFFRDPSGNPIEVKGFKDLATVYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W137</accession>
    <name>K1W137_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W137"/>
    <dbReference type="HOGENOM" id="CLU_685476_0_0_1"/>
    <dbReference type="InParanoid" id="K1W137"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854492" evidence="1">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="402" mass="45537" checksum="82E788E413B721E7" modified="2012-11-28" version="1">MVLLSLLTAVIAIAHPAVAEMMCCGELSKWDEKKAWAQREIFCNNPRGAFNNGEAQESYWSGKNEFGREKEYDRRKSGPLKPAFFYGRIDEKGRNFDNCWRATQELIEQCARQGKAFGSWKDEGEAYGMTLTGELDTRQKVTVEHFDVSRRSAVAPLRRRLAKRSVDELSSISSHHHLRRLVKDGQYFDVDGEDIHVSFRDTVADLPKRDLPSGSERGADGLWRRSEGLQTTDGMAHHWEETYHADVNVATMLREGLAKIKREEARVGGPWNTTLFVGPELGKRQLEGPTSSMQCWNQYLQDNGAGYTWTVIESGTFLSGSVPTTCVGNEYLNTGGRSDPLKLQKEEELCESFSIPFSVKQLQHLVRQFAHSRGLEWKACYKQSDLPDSARCADKWRATKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W179</accession>
    <name>K1W179_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W179"/>
    <dbReference type="HOGENOM" id="CLU_1760082_0_0_1"/>
    <dbReference type="InParanoid" id="K1W179"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852609" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16401" checksum="825708329329291C" modified="2012-11-28" version="1">MLTDFILALGVFAGSAAAKGAFLVWSGGGEAPYFTSPGDYIKSGNRFDYFGAKTWTWDQTGVPSRFELSGDTGLCLAVRGEAKVDAGFEIIKCDQAPKWSLVKVDEHGSRIKLDGTDLCVERTGLHDAVLRTCYPADHADVINQDFQAQCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1A4</accession>
    <name>K1W1A4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1A4"/>
    <dbReference type="HOGENOM" id="CLU_750455_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1A4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="369" mass="40060" checksum="276D83A7546692B5" modified="2012-11-28" version="1">MPTENSTTLSPDSLETPSCEHSHRSLAHGSTDGLLRTSESSDESFNETTESPPPRTPATPQESQTGTLPATATVAPPVNGPTRPTAAHLRAKRKPVPSVIDLLGYDPGPMPPPPMTPATPGTPGTPFTAGHNGGNRFTIGPLAGIDLPDLDGDQRSSGHSSKYSGITLQSGNPSVLSLPMRVLEVDRPSLESTRRTPVRRSTFDCYSTYTCNYNNSKPDLSLARSATEGNGESIVPPPRRQSLYKSRSGKKPSAATELEELRRMTHYASMDFDTIKRQNRANQSSFLVGDNDSDQGSINSSPDGLVTKRLKKLSLKKKNTTNYTKASAKLSSTIEEKQREQPKGWLEWVCDVVPCLHREKVSLWGSRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4Z5</accession>
    <name>K1W4Z5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4Z5"/>
    <dbReference type="STRING" id="1220162.K1W4Z5"/>
    <dbReference type="eggNOG" id="ENOG502RDQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358297_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4Z5"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="357"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="765" mass="84716" checksum="F8E490AF305B32D5" modified="2012-11-28" version="1">MSATSTPSQSGPPGADPSSSGQATPAKRKFNWKNGPPSCKECVRLKLKVSLAAIAPWKKLTSSVLAILAVLELRSSRMREDLSRRNIGWKVRYEVPDALPHFLHSLTHRPSKDQATIARLQKEIDELKSRLELVAKHSPVEPLGISHPSVDTQASSIIPSANDEDYTPFTAVSPAAAQAHHLQPDQRDENRLDPASGPGSGVIELGREGIRFFGRGAGSLFIVEDDSFPFMMADKTILTALHEFLPDAPEAFRLAKLYENDTVSKVLELIYSGPPVREQIHRVPPHRLASVMMVFALALCYEGHRPESAKYFNAASALLCVPERHFMVRHSVAAVETLHLMVSYTFNNSHPDGAKAAWPILGLCIRLANSIGLHRDQGEWGLSEAQKEHHAVLWWESMTYEILQSLNFGRPYSTPMQLSDCAMPPMPPDGGAQPNDAIFHLYKYRLGQVFVPVANYLALSKLPNYSTVLKMDSEIRKVEAVAPAWLKWQEFGTAGFAGLSDKQIVQQHSATIFFHMGLLLLHRPWFFKAVTAGSEPLLGPYAASFTTCVTSARKHTRLVASCFKAVPRAACGWRYFTFHLYTAAIIFFSVLRRVPTSMMADDVRSDFLAAHQTLTEMAEMSDIARLALPMLDELKRRIEHPEPINDSKDDGGLDDLLGSTITQWQGGDPAQLPQDPNQFSYWTTNGELNAVNSAPTPLDPNMLGGSGIDFTQPFSAPDQMTMADPLIQTLLYWNVIPQADAQQQQQPQQSAQPAQQPPQPHYPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5G4</accession>
    <name>K1W5G4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5G4"/>
    <dbReference type="STRING" id="1220162.K1W5G4"/>
    <dbReference type="eggNOG" id="KOG4582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268865_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5G4"/>
    <dbReference type="OMA" id="CEQCADY"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="398"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="473"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="540"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="924"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1190"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="926"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134617" checksum="1409D0DA998219C2" modified="2012-11-28" version="1">MFVIKATLRDETRRISFDVNGFPNYSEIQDKLRAAFSLPATAHPFWHNVLFYPDDAKNSRIKFKQHVCDADDAGQQPFKSVSGYPSPMLVFNVLTTSDPRLNAIRDYHKASKMQAKANELDVAIAAIDEDLLHRHQLLVSLEDKLQQCRREGDALGVSFWSDRVEEKRRSLPQLNEKLRSLRTERRAIVEELDRMRPSSPGLSLRQWADSQELDEIRQMRDTDQELAAWQIENADATFPPLESVLNGSSRFPTSRWSSGPWGNMPLPPNSFRRPLPDPPAAGGIGAIRDIFASSAANAIPAREIGAVLDRFLEHFQGQLCDTLDTFASRISPNPPQEAAAPAEVPEMKAESSEPHIPGAFVSSTPAAPAVPEAGTATDEKKKDKTKKHCHGHKGAYRHKHITCDGCLTGIRGMRYKCEQCADYDLCGSCLAYLHTSDLHPVTHTFRAMLHRGLEERIKFGGTEPTRATHQASRHPATCDLCSENIVGVRWKCLNCPDWDCCSSCARSVSLTHPGHSFVKLHKPTDYVGNAAWDAKSNVHHPFVVCDGCNTSIRGPRYKCMHPSCLDYDLCEKCESQPVPIHPEDHPMLKTKTPLHVKVQSSFDPINEVYDDHHRRYRVSPRKERKARKPEAEAESSSQAQKAAEEKPEVKAEAVQVDSTSEAEPSLIDMSETPVQPPIDRATTPKPAKPENSRAFTRGEEYAKALDSLFQTPLRVPGGTVSFKKDFDTSRLAQSVVSNVQNIAERVSQSVASTIAQGAVASADLGAEPERARTPTPVGAFPQQGYTVPPPVKTPPRSHLDAQQKAAAEADKVAASIKKAEEAAQAERQKAMAESNRVSREAERAVDESKKATNEDFVSSLKQAEEEIRQAMREIRADRARREAEKAKAKGKAKAVEVPAPSQMEETEREDPIVKIIADAAKQHAAAFEKAREEEKSKEAEKEVPKEESKKTEETPEPERVDPISSIIAAAAAPKNAGQEPVGPHDIFTWVRHVTIPAGTVLPAGAEFTKTWRVRHYASGSEYNFDKLRLVHTTEGKLGPACKTAQVVFPSDIVNGGDVEVSIAGLIVPEEPGKEITEQWRWEDAQGVVYGQPLRVRINVEAVSSGESSMHASSFVLPQQKLATPGTGDSFYLPTPRELRMAHRPALDADELSEELHSVASASDAHSELHVVDDDASSTFSFSDIERDSAVVKGAQTVTSESDEDYDFVDTTDEDTESEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5K7</accession>
    <name>K1W5K7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000231">
        <property type="protein sequence ID" value="EKD04208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5K7"/>
    <dbReference type="HOGENOM" id="CLU_1526235_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5K7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="176" mass="19416" checksum="4ECF5AD04F088208" modified="2012-11-28" version="1">MLIPLVCHQSRREKLRPEPVLLVGATPRFTALPQPGPALIHSEPADLEQRWGAHGSPTSTVESVNMTLNFPRARAHLAAPPTLGAPARLASPAILAVNFEEPGSHVDNPIVLDSAPSSRAPSPLQPVDMHQQLARIHQENQQLQAQLAQERHWSAIADRRIQRDSRILRTIRKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W632</accession>
    <name>K1W632_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000418">
        <property type="protein sequence ID" value="EKC97228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W632"/>
    <dbReference type="STRING" id="1220162.K1W632"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="K1W632"/>
    <dbReference type="OMA" id="NNAAWIS"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="152"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="589" mass="64759" checksum="F09148E68C0C8D4E" modified="2012-11-28" version="1">MSVNSRQSFDDKKDHDYAVEAVDPARMWDPEAATGGLQRGLKNRHIQMIALGGVIGTALFIGTASALSDGGPLGMFLGFLSIASLCYAVMACLGEMLVHTPIPGGHIASEVPPRTSPDLHNPPGPRYRFSDPGVADSHSSTPYHTSDQALTFPSLAGRYFSDSMSFALGWFYWYLWTILFPTECSAVAILFGYWLPDVNAAAWIVLSLVVCTILNSFSVRVYGESEFWFASIKILLIVGLIITSIVVTSGGNPKHEVIGFKFWTGVNGPFQQYLGIPGALGRFLGYWATLTRAAFGMVGVENIGLTTGETKNPKSTMAKAIRRVWIRIVFFFCVTVFVLTLIMPSSDPRLKIKTGTAASSPFVLAFTRVGIRGLPHVINAGVLTSAFSAGSAHMYLGSRALWALSFNGRAPKIFQRTNRYGTPYLCVAVAFAFGLLAFTSAGATSSAQVFDYFANMTSQVGLISWAGIAATYLRFYQATKKQGFNRKELGYRGWFQPFVGWYTLIFTCIVTLFNAWTVFLKGHWDTADFICGYLPVPLFFIAYFGHKFWTKSHMVPVMEVDLVSDSEPDEGEEVKPKGNIFARIWEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7S5</accession>
    <name>K1W7S5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">A1Q2_08000</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W7S5">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7S5"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_4_2_1"/>
    <dbReference type="InParanoid" id="K1W7S5"/>
    <dbReference type="OMA" id="FIGTMEW"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="642"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1221"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1247"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1300"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1341"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1366"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1405"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="212"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1186"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
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    <sequence length="1664" mass="185586" checksum="995D24C7E3EBD707" modified="2012-11-28" version="1">MSRPGQDPYSSSSSPPHGSYNYAYDNYGHPFDNNYASGSMPSQQPPLYREESEYSKYTQYPEDDIEPFDINQIDPALRLRTTKTAHSVIAESIRSEGERVQRRRSRLLKHLKRHGTTRLRSAKSRRGRKHHGDDQDGGHDGLPSIVDSDAGEPPSKPPQASGDDGSGGSGSAVDHAAEGLGLKKKKKPLTRRSIYVNMPLPADQLNAKGEPTVSYARNKVRTSKYTLVTFLPRNLFEQFHRVANIYFLALVILQLFSIFGATTPEIAMLPLVAILGMTAIKDGIEDWRRAKLDEEVNTSAATKLGNWKNYNQPTDPRNWFERLFHLGPGVRKLREKEAKEGKQVVFERHAEESEQAAMEHLYGNGVDPNETADTSHLQPPNASPPFHALKGSDSIMGVNPSRGRAISNASSAPSTWSRRSTGVIDYSKSAPGTAQWERTLWKKLEVGDIVLLRGDEQVPADLMVLSTSDPDNLCFVETKNLDGETNLKVRKAVKATSSIGSEEDIEHARFVLDSEPPHANLYSYNGVLKYRPAAGSTKVDVAEEIEAVTINEILLRGCTLRNTKWVIGLVVFTGADTKIMMNGGDTPSKRSKIEKETNFNVIMNFIILLLLCLVTALLHGYYRSLDNESANSYEQHAQASDNIYLDSVVIFVSSLIVFQNIVPISLYITVEIVKTIQAYFIYQDIEMYYAPYDTPCVPKTWNISDDLGQIEYVFSDKTGTLTQNVMEFKKCSIGGITFGEGITEASLGAMKREGKDVSHTMEDQEEELKQKKEVMVDQMKRLYKNRYLRDDKLTLIAPELPKHLGDKGDPLRAQVISFFRALALCHTVLSDKPEPEDKPFVLDYKAESPDEEALVAAARDVGFPFVTRNSNKVDIEVLGQPERWIPLRVLEFNSTRKRMSTVMRSPDGQVVLFCKGADSVIYERLAKDHDEALKQATLKDLETFANGGLRTLCIAYRNMSEEEFNTWSKQYDAACAAVEDREGKIDEACEIVEHSLQILGATALEDKLQQGVPDAIEMLHKAGIKLWILTGDKLQTAIEIGYSCNLLTNDMEVMIISTDLPEGARAQIEAGLNKIASIQGPPATKGGGKVAGMDPSATFAVVIDGESLRYALSPELKPLFLSLGTQCSAVICCRVSPAQKAQTVKLVKDGCNAMTLSIGDGANDVAMIQEANIGVGLFGLEGSQAAMSADYAFGQFRFLTRLLLVHGRWSYVRIADMHANFFYKNVVWTITMFWFLIYSSFDATYMFQYTFIMLYNLVFTSLPVGILGAFDQDTNARASMAFPQLYKRGILGLEYTRFRFWLYMLDGLYQSAVVFFIPLLVYWDGATWSANGWDTNDMYDLSSTIAAAAVITANLYVGINTRYWTIIPGIIIPLSTITVFVWIALYSVWAPQDYYGVVNIVVPTFNFWFTILITVALAVGPHWLLRAFRQSYLYIDKDIVREAWVGGTLKDELGIPHRKNRKHRKHRDLEEARYHKRTEGLDTYQPTALEMTQVSSAVDPLLDSNSGSLRSPTEVPSLPNSPEPRRTGPVRPPRAPVHDPPDVHAPPYEYNYTGADSPYSRGGGSPDFFANGAVQEPRPTRAPPSSFPQQYGWNSTSPAPTTRQRKNHQQREDLSEVMDDGNSHQQPGPDYRPPSTAAGDFTKDTQWANRPPSEADPAFAGYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1W945</accession>
    <name>K1W945_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245629_0_0_1"/>
    <dbReference type="InParanoid" id="K1W945"/>
    <dbReference type="OMA" id="NSERHAM"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="971"/>
            <end position="1159"/>
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    </feature>
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    </feature>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50190"/>
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    </evidence>
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            <dbReference type="EMBL" id="EKC98118.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1449" mass="156615" checksum="6F4CFE90EDE8DAC8" modified="2012-11-28" version="1">MSSSPTPFAVSPSPSAEIRSQAIAKLKRAASLPRNPDGRRALQLQTPPRPSPAHAVQPGLGPDDSFNGSSTGHSVAATPTSIRFEDYSESEELLDQADPFDAYAYGNGTMMQRSASDSSGFIPQVTYSTTSTPFYSAQPSPVSGPGPDWAAYQLAQSYLPSISPIPTSTPPSAFPGNLTASGAGRNTPSPLPTLGELRNLSRSNSAAARANAMNKLTGGTYTPTPSRSLASSTPVSSEEDVTLGLPGARPSLHRAGTIGIPRMFGLAVDEPVDDDVVTPPSAEAPIPDTAFDVPRPRLQRSFTVSSSNMGEERRSAVGRRMVERLAERRAARQKEEQEVRVLWEERRRTKQLSMMSGSRDSGASTNTNATEQQRTPLYSPQAVTANSISPLASIALLGRGPAPTAADRNSEPSEEGAFEFESHLNRSVSTRTARSARGEVIEPKVPSPLSENGDVYDDGNRDTKDYSEQSHSYHEDHEILETPQDLPSRPFAGATRHATQASTSSQGTVVPPVPPKGDVFGGGEHLGRPNGSTPSEPRQAPRVPENGGFDKNVLGASVRSDTGHGGYFDDASSNGHSSARAISPMSPREPAHSHGDHRQHKQTPSMSKQIGRNMLAVLRKRSGSRTSNNHDGPVSPGISRQVSDESVQNNPNDRARHQGTNGTATPSTSDHLASSTASSVQHHSNHSGAASPSFLPRAAPNDPRVHNSKLSPFPGIQALEQQKNRSASEPVRERSQATPAGRTSNDDGTSSSHGHGSSSHGHGQTMHTRGVSDDRSADHHSTSNHQTYSQSGHSHTPSATYSQNTHNSQSTHGTNGSADLAPNLMRSSSRSRPEIPAFMTNRRRAPPPPIELGTSNVDSIDDDSDQTTMPLSIKSQAVISRMNALMALPPDDPSRPDFLDDPPRKLLLAQQVLQVVNSQTVKDRYLFLFNDILVIAKPLITQGAMATLDMQFMVKSIVSLSSVVVSGITDEPTQEPPRHPVVRKFITSFADDPQSAVHNLMERSQPKIDTVTLGSLLFRTYELDKGQLGLLLANDQPLLSTFLDRFHFEHMDIDNALRVFILAVRLPSDVQTAEALLRGFAIGYHRANEGLLPYDLAVAQELVVAIVSLNDMLYSTFGFAFPNHAVSRDRFIHSFRNRDLHHQVPDETLENLYYSIRNNRLVQALGPQDAHRVRDIQLEPSRPPSKLTFNDWSDPITVSIPKPDSAFGIRLLGSGLEFDPPFLDFSNTAECTFRVRGTSLGPKSMLFGRVGSNAERYPGLGNSRAFHVERAFMKHTFQVAFMSTSGAKRKYCFSVPDAAARQRWGSLLSRQIWLTTETKIGAGAPPTPAFKVRRAAEAVGLQVLRDALIPKDGEDAARSSHGHTPRKASISAAYSEGEKDTVSGMAGLQTGKELVLLARQNSLLPGVLELLQSGQERSRYQQPALNGGSVSSGSLRSHDLKAMMDARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9B3</accession>
    <name>K1W9B3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_07530</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heteropentamer composed of five different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9B3"/>
    <dbReference type="STRING" id="1220162.K1W9B3"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="InParanoid" id="K1W9B3"/>
    <dbReference type="OMA" id="SINKRFA"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000018">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="140"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="280"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="485"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKC98198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="707" mass="77945" checksum="CB98E823185025DD" modified="2012-11-28" version="1">MAFPRPKPTTERANPPFNVRKLAATMQGSEKSLKLKEKFMAEIARHPAFRNNDIHDLTKDEVRERTAEKFASMVYFFTSESIEAFQERMALISIADPAFWTRFGVHFGLFLGALRSNATPNQLSYWIEKGALGLNGVIGCFAMTELAHGSNVAGLETEAVYDHNSDEFVIHTPHLGATKWWIGGAASTCTHAAVFAQLIIDGKKHGVKTFVVQLRDTETFRLLPGVTIGDIGKKMGRDGIDNGYIQFTYVRVPRAHMLMKYTQVSRKGEVTEPPLAQLTYGALLGGRTSMVADSSNTAKKALTIAVRYAAVRRQFASEGKAVETQLLDYPIHQRRLLPFVAQAIAIGFTGQKLNAMYTDMTESLERLEPGDPSLMETIEKLKETHATSAGLKAFCTWACLDTIEKSRQTLGGHGYSAYSNLPAMYADFAVQCTWEGDNTILALQAGRALVSAYSAAVSGKKVAPGVAYLADPKTLSAKSDGSFSLADIQKAWECVAANAVKRAAAEYALFRKEGMNKHDAMERCSQARFIAAKLHTTGYIFKMFRAAVEEMEASPETDVLRTIAHLYGLWQIEELQGPFLKYGYLTGEQIDSISLKVNDLCLEVRQYAVPLIDSFALSDHIINSPLGKWDGAIYEAYFAQVQASNPLPKEHPYFTRLIKPLLDRQPGDLEDAGEEMGLDDEITSLAEASKQAIKAAKAAKAAKKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB23</accession>
    <name>K1WB23_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB23"/>
    <dbReference type="HOGENOM" id="CLU_1497260_0_0_1"/>
    <dbReference type="InParanoid" id="K1WB23"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="180" mass="19429" checksum="A0BE115378386F6B" modified="2012-11-28" version="1">MEGVLVCYEVCAEADSHRFDRSWGVSGGPTASELHQGMLELAALNIICNRHRLPHTSTKVPHTSTNQWARRSWGAGLVSAKIVDPSEFRIEGLSRVTDHMWTPGGWAGTLFTVLHLSRLLYGDRTSALEIWTCGKCAMGKQWVGGLHMVNVGAGDDAALGGTYSHLLATGFRDSGTLGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDN2</accession>
    <name>K1WDN2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDN2"/>
    <dbReference type="STRING" id="1220162.K1WDN2"/>
    <dbReference type="eggNOG" id="ENOG502RY6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_297203_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDN2"/>
    <dbReference type="OMA" id="RIYFHTP"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1025" mass="108988" checksum="57D9B9118164530F" modified="2012-11-28" version="1">MGLPPKPGGQPPLPAGPAPNYGGGQDPQAAHAAAWAAYYQAQGYNTAGYNAGAAQPSAGAGGTPPNPYANYGYGAGASHAQNPGYNAAAGYQQPYSGQQQGQSYRPPPPQQQGYNNYNQANQQGYNNYQGGPGGGQGYNNYNGQGAGYTPQPNQPYFPQQAQSGSYMSGGGSGSGGGGGGGGGDRGRGGNRPYQPQSRNVSGASNPPRPPSGGFPPAKRPRFDGPGGGGGQNGSPQGASGGNLPPRPPGGRPQQNYSGMARPMSNNRGGGPIPRIGFGGPGGRGGGGGGQGGGMRGGGGMRGGGPMRGGMQRPGQRRDNFRQPGPHTQGQGKRVDQSPRMDRKRKEKTEAKTTMTDFRIVGIEVKSLDWSWGLIGEHVFEEDEKEKEPEKTEVKEERKEEPAAKDEKKEEDEEEPKEPPSEAKEEEAKEEKPDAKPEVKEEMKEGAEADEAAEPTVGAKRKAKPSSIDGDESPKKRSSSFVSHKDSGSGGERNVLSSPESNQNRFRIYFESPPELDRVPKSARRNPNKRWRRESSSVAPSRLGEVEEHDEENAEDHGDHAEHSEAQPEGEAKPADAEAESKEGKESEAKPQPEAEPKAETEAQPEPSESKDEEKKEDGGEEAGDVSMVSASGDAAEDTAAAVEAALAESAQNTASAYGNRTTKSRSRRWSTSSLESHQSDAHALGAEDPNVPQPSVNRVSVLYEESSRRLVFDASVVSKIRIFRGEGRIEVDLLPQPAEAKPDAKADEKVEEKPDAKPEGEGEEKPTDESEEKKTEAADEAKPEEKDDLPKGVLRFISVTRDKLASLSDDGSLPPLHRVNPGQGVTLTVYLNKKKPLSEPKWCRTNQADEWLWEQFGRRSESGWRGKLEIMDPDAPPTLATILDAWKTSSSSGTAADRGAFTASLLASPNDLLEILLRLTRGERNPTASIGTGPTSANGPLATAIRADSPYASHQTHVSLAILAMYRLTTEYAAQAGQSDVLNEKIADIIKSLPTHMIHKSLDGLYKEWQKAGNSGNAASEAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF33</accession>
    <name>K1WF33_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF33"/>
    <dbReference type="HOGENOM" id="CLU_2198845_0_0_1"/>
    <dbReference type="InParanoid" id="K1WF33"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="108" mass="11999" checksum="D902BCC263337C71" modified="2012-11-28" version="1">MLALTVRVSARPFTRSWIRLMSSNQTDSQADVAADRAASDFPARPNAEMQADTVKFLKVEDQLRSNPPKDAEQAAADFAKLQEVGTTSWLSLTSRPRSPSRLEENGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WI85</accession>
    <name>K1WI85_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WI85"/>
    <dbReference type="HOGENOM" id="CLU_912731_0_0_1"/>
    <dbReference type="InParanoid" id="K1WI85"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="274" mass="29917" checksum="756BB4534814CE9D" modified="2012-11-28" version="1">MSSSVPSLPSTTVSAVPSASASPLPTDVAPRPSSGPQPPTGRPFFFNPTHSDEAQVCYFLVEAPNEKEPYYLPPPELRKIGESYCSDIGIWNKDLFACRTETANSTAVFETRAKGNQTSKNKTKCRPYGEYEESIRSAFWAEPQWPEHYDNSTHSIAIAYGTFNGTSTGARCCMIVNGDPVESTGKDLPYSANSPNPSNFSDYRNHALSPCLVIKDKGDKYKECILSTDYNALPMVESFRYYEVKSDSGQAATHKTALSFTLLAVATALFASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIA2</accession>
    <name>K1WIA2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIA2"/>
    <dbReference type="HOGENOM" id="CLU_829460_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIA2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44490" checksum="F1B7CDE13E5E066D" modified="2012-11-28" version="1">MASTTSPPISILPEEILLLIAELLPVSSLLNLLRVNLTFHRVGLAVLLRPERSVNFLSTRTSNSHLPFNPCFSNKDYASEVRSVTVNPHAHHWCSQFDVPDMPKVDVIRLQLAEQLPDEHHWRILHSDVPTPTPFFGGPYEEPRCPLLNVPFASMLVVAETISYKKGIKILLPSTTVSSLRSTVLFLKAHQGYDPRAIDDADMFSGPETGLSWECLSRFMPDNIRSFTLVFESPQLDSYSWIGQKNDSAYGQHMMAPADELLTAIFDMCDDLGRSDKTRSMLPKGFETFTVVLPDGVLDSVCQKYFQDQVDLHLEQFRQKGICTVRIFSMTQLMGSKEYAGVMTEKEQEMWSERAHLSHYEMSIGEVQECINLSACRTTMPCFPAGDLLLSFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIJ5</accession>
    <name>K1WIJ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIJ5"/>
    <dbReference type="STRING" id="1220162.K1WIJ5"/>
    <dbReference type="HOGENOM" id="CLU_1385054_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIJ5"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="197" mass="21627" checksum="BA7B13FA8E3AD4E6" modified="2012-11-28" version="1">MTDPALLSLCYPTLLVFTGAALIGVVQTRKAENKEPPVSSETANNILLAGLAAQTAFFTLFLSLLGTAIARIGRIPTQYNLRRNALTILLVDLAAALLILLRTVYRLAVECQGYFGSANSSQVLYTCLEYLPVILAMAVFCAFPIYRFMPSEEQRRSLETDIDPAELDGINGGEEIKDTYSAQLEARRSKESARPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJ09</accession>
    <name>K1WJ09_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJ09"/>
    <dbReference type="HOGENOM" id="CLU_055175_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJ09"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="447" mass="49302" checksum="5841D5F7AF6B75F1" modified="2012-11-28" version="1">MLQLPVELKLVIVRQLPSEDLFTLLSVSKQFKALVHPVFYERLAFTKAGFAFAHAPNPYPFLSIPNLKGQLSVSDEEREAIMKGIRQITVAPHDHAWCTGWQTIQTSHLPARAEVLKIELAYPYRDGMACCHKPDICGGCPEDDDDDEDHIHPHLLCGFIAALANVRAKKIVIKNYPALLNGASRLVSLPKLAEDASEMVIVLRPHTLEDKSYREVPYFADLCSDGDKYLGASALMNMVSAGVKHLTLVFYTPYSSAEWAPCCKHYEYDWYQDGCVTPCPCGGGCYGESMPSGEDMVQQSCWQSAFWIDLASGMAASKAHITIVNYSAIIPDGLDRYEALRALDKGKRSTVRKTILRQLRKAHASQEEYEARAADIAFVSMESWICSGAWEEVFGRKEINPWLARIEKLKSKAKSSPATTNAVPTTVPAVELTGTATASLSAAPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKM8</accession>
    <name>K1WKM8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKM8"/>
    <dbReference type="STRING" id="1220162.K1WKM8"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388304_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKM8"/>
    <dbReference type="OMA" id="PQMMSFP"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="620"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="775" mass="84556" checksum="FDD3D885977CCC7B" modified="2012-11-28" version="1">MSLLAARPPAPEERASVVLPTVKCSTCAVEIPLNYLGEHICGSAPAPRANNFGPSPFRHGGPNQGSRSHLNAQTGGTIKRPGAPTMLRPSGPSRFDDELVAPSRFGDYTADVPMSAVSANMKDGQWPSHEQKGMLPPRPLADDMPPPSPTLPDTRSGGNAGMAGVGRRAFAAAAWSVRAGVALAHGAGKDFAHDHGSGGMHDPSDASPNPSPMNERPPPNQMRDGRAATPRQMPVAMPMPRASPSQQSPVDYRPPVNRSASSTSSRSVREPVILPKVPLSGRAPSRNQSRNGDWRAPSRAGDHRGDEFLPARPQDIPNRSATSQSRYSPETERAHNNGPNSPFFDRYRQMVETQSDQTHDVSRSKYSPVEERSRRHHPRHSSYDAGSSIGGEESSLPWARSETEEERYDHRRYPTDGSIPSTSSSASGDHNRGGDSSSHEAEMVMTPSHSWEGLVERTANVAIHDDKLKANNSPYAFPGLNFGESIADSLHDIHDEDDGEHFVVGAPLPDRRANGHLRSSSQSTVKFDELRGAVQKKKTSPLPSPNLSRDLDPPRIPLQISNSAKRSPDLRSANVTPSPTSSRPRRQCANCGEAVGGSKRFVERDGIVLCEADWKKLYLPACRRCRQPIEKSAVSSSDGQLKGKWHRACFTCTRCDKPFTGNDFYVYDGRPWCQYHYAEEANTLCSAPECRQPIEGPCILAPAGANSKEQRYHPGHLKCKVCGDQNMFEYYEIPVEGGTTDKYCELHYKNLVSSGGAGGRGEKRRTRLVDLASFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM29</accession>
    <name>K1WM29_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_03531</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM29"/>
    <dbReference type="FunCoup" id="K1WM29">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WM29"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="InParanoid" id="K1WM29"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="399"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD02169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="553" mass="62785" checksum="209A4E968ABD2162" modified="2012-11-28" version="1">MIAQNSQAELHLLAVSAIVRELIETHEAASSSTDPVKAPDLFSLRNKYSRKYKLSATPRLTDVLAAVPDEWKDRLRGWLRAKPVRTASGVAVVAVMCKPHRCPHVAMTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRGRYDPYDQARGRVDQLRSLGHSVDKVEIIIMGGTFMSMPEDYRHRFIAGLHNALSGATAEDVDEAVRFSEQGRTKCVGITIETRPDYCLKPHLSQMLRYGCTRLEIGVQSVYEDVARDTNRGHTVRAVSESFHMSKDAGYKIVAHMMPDLPNCGVERDIWQFQEFFENPAFRSDGLKLYPTLVIRGTGLYELWRTGKYKNYPPNQLVDIVARIMALVPPWTRVYRVQRDIPMPLVSSGVENGNLRELALARMRDFGAECRDVRYREVGLHEIHNRIRPQDLELLRRDYTANGGWETFLSYEDPEQDILVGLLRLRKCSEEGTFRKELVGMPGGCSLVRELHVYGTAAPVHSRDPKKFQHQGIGTLLMEEAERIARDEHGSTRIAVISGVGTRDYYRRFGYWLDGPYMVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQS7</accession>
    <name>K1WQS7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000252">
        <property type="protein sequence ID" value="EKD03404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQS7"/>
    <dbReference type="STRING" id="1220162.K1WQS7"/>
    <dbReference type="eggNOG" id="ENOG502TH7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490183_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQS7"/>
    <dbReference type="OrthoDB" id="2585427at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="556" mass="59047" checksum="025F0363A79EC99D" modified="2012-11-28" version="1">MGLGIFNRNRKSLIVPLVPSAQPLELRVLVDAGPAARDAFTISVPAEGTVDSIREAAAAHIGRTGIALFKWPGPGAAIVAVGQHSWIAGSLSEPRGIPFVRGTGTVVLTVQAVLRSLNLTFADQSQVSIPWQAQYQASAYAESYGIVPSLLTQFPAYNLDDATQMHASGGLPLPAYRNGSGSLRLKRSSYYKGPAPTVAQWFPHIEEGTINILARSRETLSAIDWVQPRVPLTLCARFSGKGERAQLVIVDVDQDASIRDLKVALLRAAGRPTHAHLMEGLTLWRVDMTEAELSAIDARGGLAGGQRPRPCASFSTPLLMADCVGARVGEFFSPGVNVSRVNPAQVSISVYVHQGAEYELAPVVPAPKFTYPMPTALQAPKRSLGPLAASQPACIETEAGEPVAVQVCLDSPSPTPSTSSEGSGDTVLPQPPCAAVRAWARSGSVSSCLRSPAARATTRPAPRTRSAPRGPRRPWSPRSRTGGARRTLGSTTLHSRAARSPPPNRQATPRSQSSIAGGHSSRTSSSRPRRSSEPLLDSHPTFDPPRTPLRPVRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSS7</accession>
    <name>K1WSS7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSS7"/>
    <dbReference type="HOGENOM" id="CLU_356469_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSS7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="787" mass="83183" checksum="8B4993AB31B44791" modified="2012-11-28" version="1">MTASERGRQPKRVREAGRLEDEWIAAGGAEEEGLECTLGAAARRKRRAAALQRMQRAAGVAGVMSVSESKGEGAVTHPVCCRQSRTDPGTPGHTNYNNITNYYLSNGHVPVTVTGCCCSRSVVLSCAIPIVGSEGPQDQPFLGFVRADLQSVARNLQPQPRAPPSLISQLTAEQEPKQKCEKRDGSPRHPGGPGDPLPPVQIPTERGEATCLRQLLPCMHLSLALQLYGCVGPCCTLPRPERRASREAEHEPGPHRIAHHADLTIRHGRTWDRPGEPGVDLNDGSACAACSTTLSRSRAESQRQQAAQAAEACEACLFPNQARAQKVEPASQFPGNGSARHERRARHSVSTGVPALPVCELPAPFGFAARTGGTSLMDSSARMDVSLRLAAYVPVLLSQHWLDSSAAPVGLASGTGALMCHPPATPSQVSGHGTRATQGFGSGGTGLNFVQTAARSAVRAGALRCAACTGHARGADFDEPWSSHLFLAVTVHQSDREAKNSSGLQQLYRQTLSPFSPRGTLSVPLRPSRTRFVGLTSSAQAPQDAYVYSCRHMNHGCERVYQAGAANPIRATTDPNMTTLAKTAVRSRHPFAQKAHPALPPLSASCKATAYVHAHMRMLPTLTRMPDKRPSVKVRFGSELVPRSRRGTCAPPPLFHSAPPMIYVGACVAPTVGHSSGTTGTASVEGESVNLPGPDHASPSSARRQIYGGIDWSTAAEESITLTDDALRSKRRRGRVGAAAGGEAGGAGGACGGLAECPLPKPGFLISTPILSPAQSSECATSDRHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTN4</accession>
    <name>K1WTN4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTN4"/>
    <dbReference type="FunCoup" id="K1WTN4">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WTN4"/>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_3_1_1"/>
    <dbReference type="InParanoid" id="K1WTN4"/>
    <dbReference type="OMA" id="EIKAFWV"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="58"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="312" mass="33293" checksum="50D011DD770877CE" modified="2012-11-28" version="1">MATAATAQSNDAGPSTSTSPATQAAVFKRLHPDQYLQRFLAQGYRPDGRKVSAWRDVSINVAEGSALVRMGDTTIVCGIKAEIAEPSGAAPDEGFVVPNIDLPALSSPKFKPGPPVDEAQTMSNWLNDMLVSSRTLPPKSLIIAPGKAAWVIYIDVVCINYDGNAYDAAVLAVMAALRNTRLPSAKYDETTFQTVCNWDDKHPLPLGRMPLCASFGVFESAGTVLDSSSHPAAKILVADSRTYLLPDPTAFEQPLLPTTITIALDENNRAATVRQEGLGGVVGKSGSELLDEAWSAAEGHIQELRQILEQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUA4</accession>
    <name>K1WUA4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUA4"/>
    <dbReference type="FunCoup" id="K1WUA4">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WUA4"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="InParanoid" id="K1WUA4"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="243"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="413" mass="47097" checksum="E0E38776C19A71E4" modified="2012-11-28" version="1">MLSTTVRSFTTTSSTLLPRIAHSSLCAVRNFSTRANNTNTTNTTRPLANSNSLPTQTLRTLSSTSNKMGLTDWASKDGSFKRQVSSFRDHIEPNGKFPAEKGRYHLYVSYACPWAHRTLIVRKLKGLDDFFDFSVVHPHLLEGGWHFETPEDAAKPPAPWSEHSNKTFPGATADKLYGKTHIAELYKKAEPEYSARFTVPIVWDKQTETIVSNESSEIIRDFNSAFNGLLPEGSAERELDLYPESLRGEIDALNEWVYDGINNGVYKCGFATTQEAYDDAMDNLIKSLDRVEEILSDGREFLVGGRLTEADVRLYTTIVRYDPVYYVHFKTNWGQIRHDYPALNRWLKNLYWNYPAFKDTTHFDHIREHYFYSHTQINPRRIVPKGPKLDIEPLGAEKRKAEDVAGSNKAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUI6</accession>
    <name>K1WUI6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUI6"/>
    <dbReference type="STRING" id="1220162.K1WUI6"/>
    <dbReference type="eggNOG" id="ENOG502QRPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306291_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUI6"/>
    <dbReference type="OMA" id="PIQSCFQ"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="908"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="922"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="988" mass="109672" checksum="7407818DC51D9FBE" modified="2012-11-28" version="1">MSQPPPNRYPPGNKGVPPLPPFPQLLHLKDSSPATQQRSRSFSGTDIADDDSTHQTMSPEEEEVDDTPQKPDIKKEKKPHATRRRVVQSCSECRRRKIKCDKKFPCGPCILRQDQARCHEVGTAEKQLVASSNYATTQDLANLAHRVDALEAALVKSGAIVPSDLEQFLKQIQSKLPPPGSGGQNPAMGNPQDADDVSDTEGAALTLEHLAFGRARVDGAHSIPHFNGISRKVSSVSKQAPGHGYHLARQTQQTGDSPSMFSPSNVKSEFRFLGNTEERGARISALAEQLTPVEVFDMYTRKTDLVLNALTRCLPSRELGELMVNAYLNRVDWLHRCELSFCRDLWALPPDRVVYEISTPFLAVYFVVITLGLYFMDSDEAAKHFSSREEVQSLCDQWYAAARACQWSSDFIANHTLENLQATILMSVLMNNRDRADAAWALLGAAIKMAQGLGLSRLGAEQQSVDGRPLPMWKGRWESLIQREVGRRIWWNLVFLDWSLAPSYNFACSIHPDQIKCALPANIEDEDLIDGQPIRPQPESVRTRMSFQLAKLNVDRELRKAMLELPAFFQPDNSNGPTSNDPKALVEYYEKITLSLAIHSRMLRLHRPWLSRGYEDERFAYSKEQCIRAARASLRMMSDNNGVAPFLEKWWIPLFYVTVSGMVVIIDLLKTAKREMKSKVTEEKIAEVKGAVDQMRKVAQSSIPAQSAIKVMDFLMAEVEERRRPGQHGVKRKSMHEADGDDEEHNLQRAVKRLIRQAQLEADSPTGSQPGNSAFVSPAADPGVITQSPSGNDSTPTNEKPVFGAYPMPPPNLTPTQSVAGDNPAQQQQLMNQQGGFNFAGLDPANLAQFARFDNRALQPSQPQLDPAVESMLSAYFPPPQNPTNGTSELGPAAQSQVPDDFLSRVFSFSWDNNGNGGGGNQQQNQNQNQNQNNNAPGSNNPSNTNTPQNETPNVPQNVNGPRPPQRQDSVTVPGYGAFDWSGHSWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVG6</accession>
    <name>K1WVG6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000188">
        <property type="protein sequence ID" value="EKD04839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVG6"/>
    <dbReference type="HOGENOM" id="CLU_1205518_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVG6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="230" mass="24606" checksum="D15D8DD923A85C6B" modified="2012-11-28" version="1">MSPITILLTQPSGDTFALPPPNTTSYKRMTPVLQPSPDASLLHAPQVLMVRTPRSRPKRRESLPAHVPRTDEERGRTPRTPDTPRVPRVSRSPRSFDLAGTEDSGAKLTPPPLPPQPRPNAEPKTSAYVLDLVLDNLKATHEASLAREGAEKRAAENHEPAKRERPRGRQRPSAVDAGTPALATVVECARDAAGAGDAPYAPTPATPIPVIGPRHSAYSGCSGTGSRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVH9</accession>
    <name>K1WVH9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">A1Q2_00805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVH9"/>
    <dbReference type="STRING" id="1220162.K1WVH9"/>
    <dbReference type="eggNOG" id="ENOG502S7J1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305920_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVH9"/>
    <dbReference type="OMA" id="RANAHAM"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="969" mass="103628" checksum="00131509566347EE" modified="2012-11-28" version="1">MSELGPREITGRAASRALSSKKLVSDWASKQDNSETATRTITVCFCSGACPTTRSCRQAVELPSEFQIPTAIDDKEVLLLLVIHVADAREEEPGDGVLFSCSNPTGLNETLPSPVVLSDVPDVGTSASAEPEEVPALVLLLPLLRQCASAPAPAPLHALAARLTTLIPPIPAPPFEAGLEAAQISSLLPEDVAKPLRECLAGLMADLPLPQAPAPDVMFGNGMGDVGVGMPMGQMGVQMPVSAMPLRQAAAFLIEYGARAHTWERNPEYASVPRLPHPHHRHIIQLGRALTTDSQAFIVALFDAAADRVLTSWSHSPSAAVRPYVFFTEALPVMLRWWRDNADPKWPYPADLQGALQGVITTHSQQLSNWFQAVNSIYTAKFSQSEPDEEGYVQPDGWSLLSLEATAVRRYVSLGLLEEEAATELIGSPVKPASSCESLMERLATTSPSHLPALETFITYASGATSSTASLGAEVASKPAPENLFVRLAGSPSLMVLIAAYISPSSLLDIITENLLDRVEDPAVRQEDPQSSLIRFGAANVQLPLPHLLWNARRVSNLEDLSEDERGHLNGWVKALFGSDGIDDEILLKTSPQGLCRLASTLVQQSIVAASSGQIDLDTLHSGLSYFAQPLLSWCLGSVVGWLCAEIERLGQLSGVHLNVLQTLVLDSAFPEPLLRANAHAMNRLLEPTSGLEPVIQSSGFDAIAVRARLQAVGGPDGSALLPDPPYLSPLPTLRSEIQAVRHIDIATQGWESRLLDAVQAALRAEGSLRVLDALLPDIVYPSVVDVEDPITQVVALICALHLQGIPLSVALVNGLVPSLFAPRSPFVPASIQPHLIGSSANGVNNATPPLPYAAHTLHRLLRSTILAVATSDDTLADQLAQYLAEEIAYQSTRPVNQPKTKRMPKGLGPGAAPDPGLVDEQKALLDELISKFEADDEFKGRFPTFVNTMAPKAINGEVANGDGDVQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WX34</accession>
    <name>K1WX34_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAD57 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WX34"/>
    <dbReference type="FunCoup" id="K1WX34">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WX34"/>
    <dbReference type="eggNOG" id="KOG1564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463808_0_0_1"/>
    <dbReference type="InParanoid" id="K1WX34"/>
    <dbReference type="OMA" id="NDEADHE"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51-like C-terminal" evidence="2">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="479" mass="51252" checksum="4CB7089496968AB3" modified="2012-11-28" version="1">MSFASFPVEQLGLTAEQERQCSRARISTASDILLVSKSDLARKFGRGIDAEKTAQGLIDAANKALMPKARKASEMPKPDEARGADPSAAGKSHLTLSLALSAQLPALSTSPGSVLVLTSERPLATTRLMEMGEAMLARHPDPANPTLDEMLDNVETSPVADADSLEHCLSFFLPPLLASRRTTEGSALLGEDIKPKEDIPEASAIDGVNGVNGASTRKKAKPPVRLLILDSLAALLRSETSLSGGGLVQRSRRLCSLSDRLKALALEYHLAIVVVNQVSDVFIGEQPKAGPEMLYAAQARHFNGQSAGGRKEAALGIVWANCVNTRIMLARTGRRKVITLSDLNPDAQDSRKRKRVDTPAEPQQQGRERQHEAEGVGVQLGEEPSLIRRIHQVFSAYGPPGSADFILAKSGVHVLPGSYRVVDLGPALRRRAARNAPPIEGGTPEDTQGTPEGTQAGEYELGDLPEDFWDDELAVGVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY05</accession>
    <name>K1WY05_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WY05"/>
    <dbReference type="HOGENOM" id="CLU_1526239_0_0_1"/>
    <dbReference type="InParanoid" id="K1WY05"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852801" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="174" mass="19524" checksum="A7433E9A9208229B" modified="2012-11-28" version="1">MRLTTVFASAIALIGISAFAASVAPPASVDQRDDSLSRRTVADTDMGTLITRAESPTLKDAINAIHHPESDYFHRDQWLKRIVDGLRDKWPNHNVFAFHRFGGDFKWGVTDKKSMEAEAAFFDFNSKTEYFQVVVFKSAGILERVGGDGGWANWGYSGWYDEDGDKVTFRNPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY18</accession>
    <name>K1WY18_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000089">
        <property type="protein sequence ID" value="EKD05559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WY18"/>
    <dbReference type="STRING" id="1220162.K1WY18"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="K1WY18"/>
    <dbReference type="OMA" id="FASCWFI"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD05559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="525" mass="56481" checksum="A43B3558CA0E8F3F" modified="2012-11-28" version="1">MTSSSENERETNSTLTNPVAPTKSRLSTATTGLSNAASKSALVLCLFQSMAGVIFGWGNSSGGVLFAMDAYKNRFGSCDAAGVCALSTTRQSAVTGLLSLGATIGAVCSGYISNKLGLRMTCILFICIHMIGSAIETSAINYKQVYCARVLLGLGIGATSGLVPVFQAEAAPPKWRGLVTGSFQLCVTLGIWGVSMCGWGMSHYKGNVSWELTVGLAMVFDVGLLIGFLLSPEAPSFLAKKGKWDQCRKSMARLRSVKLDDPRLDVEMEKVRKKAEQEKELGSVSYKECFTVENRNLWRLMIGVCVQIGQQITGINFFFSYGPQFAQVAGMSNAYIFQIILASVNVGMSFPGIYAVDHSGRRPVLLIGGFIMFVGQIVTGSVSKAYPDAKGAGKVLIAFCTFFVGAFASSWGPVAWVVCGETFPLRISARCVTIGTGANWLFNLIIAFAAPQIQQRIGTGICFVWAGCLALDIIFAFFCVPETKGMSIEDIDAMYHAHIPAWKSSKFRKQAVSDEKNDELAAVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1WYI3</accession>
    <name>K1WYI3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Putative retrotransposon nucleocapsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_00008</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000005">
        <property type="protein sequence ID" value="EKD05684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1WYI3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WYI3"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_38_1_1"/>
    <dbReference type="InParanoid" id="K1WYI3"/>
    <dbReference type="OMA" id="HYHEYLA"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000003">
        <property type="entry name" value="Transposon Tf2-6 polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="19">
        <location>
            <begin position="394"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="957"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="18">
        <location>
            <begin position="1267"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1331"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1341"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1356"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKD05684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1367" mass="157479" checksum="B44806066323C839" modified="2012-11-28" version="1">MALFSTGVPLDPEEHLCIPITIRYGQHEYDTYAMIDSGATNSFINTRFLASTAIRKRLKDIPQEIQVIDGRPIASGQVTHHTGPLELEINGHYETLALDITTLGDYPVIIGLPWLARHNPLINWTQQTLVFNSGYCKRNCSKRKYRSKNNRVPTMTTTMKMTSQPIMNGNLPGTEATDTPTNQNNKRCCGSRMSRPDNRVPCKGADHGAATTTTSLDVNSQDARPTSHSIKAVEVRKTIKTTRPTTTRPVPVTPPSSPARLAMARKIALMKTRREKSKPITVALVNGKSFKFSLKDAKVYGITMFNDKGLIDPKPAQDDDGQDLAKDELRKAVPPEFHEYLNVFSKKNAEKLPESGRYDHAIELEDNQQPKFGPIYGLSEVELRVLDEYLKDNLKTGFIRPSTSPAGSPILFVKKKDGSLRLCVDYRALNKITRKNRYPLPLIQESLDRLKTAKYFTKIDLRAAYNLIRIKPGDEWKTAFRTRYGLYEYLVMPFGLTNAPASFQYLINDVLRDYLDNFVIVYLDDILIFSKTHEEHVTHVKQVLKRLEDNSLWAKAEKCEFFQDSVDFLGYIVSDKGISMDPKKVEAIVDWPVPKNVHDIQVFLGFANFYRRFIKSYSKVTSPLTRLLRKGINFEWTTKEQEAFDDLKKRFTTAPILQHFQPDLPLVLETDASDFAIAGVLSHSIDGKLYPIAFYSRKLNNSELNYEIYDKEMLAIVEAFKHWRAYLEGSPNITVYTDHKNLEYFTTSKVLNRRQARWAELLAQYDFKIVYRPGSKMGKPDALTRRQDLRGGSRAAEAPPRTLLKPGQYISATTNLTTNDLNYDNMTETIKTTQQTDPELQDIIKHLRQPSLLRSSEIDVKLAQPYTYDMNTNLLYYDNRLYIPNNHALKLQVVQHAHNHPTSGHMGQQKTLDLVERYYYFPGMRQFVKTYVNGCHTCARNKPTRHKPFGPLQPLPIPQRPWKSISIDAIVKLPTSNGYDSIMVIVDRRTKQAHFVPFTEEGFDSPKLAQLYRKHIFRLHGLPDDITSDRGSIFVSNFTKELNKSLGITSNTSTAFHPQTDGQTERVNQVLEQYLRHYCNDLQNDWTSYLDLAEFAYNNSVHTSTKFTPFEANYGYHPRHPLAPPAVCDVPAVTDYLSRLHNIQNNLTTNIEIAQRNQAKYYDRTTKNKPHDKDGEPKFKVGSWVFLNRRYIESKRPSKKLDQRLLGPFQIIKETKSPMAYVLDLPPSMSQLHPVFHVSLLEPMREGHNDQYQDPPPAIEVEGEPEYAVEHILDSRINPDDDGFDYLVHWKDYTNDHDSWEPWEEIHDTTAYKTFARQNKYNNRHVFPTTYHKRKQHQKQDSYQPISTTTEPNQLRRSKRIRHHKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WYJ1</accession>
    <name>K1WYJ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000004">
        <property type="protein sequence ID" value="EKD05694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WYJ1"/>
    <dbReference type="STRING" id="1220162.K1WYJ1"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_5_0_1"/>
    <dbReference type="InParanoid" id="K1WYJ1"/>
    <dbReference type="OMA" id="CTWHETH"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852809" evidence="7">
        <location>
            <begin position="19"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="532" mass="55963" checksum="A0C00E29720D5D56" modified="2012-11-28" version="1">MKWAALQTALLLAAPALAQTTAAQTSTAPLAPSPTESIGCHAHGDHWHCDGPATATGTAAATVTPAVHDEHDHEHEEEAHAEEGHAHEEGHDHAEEEHDHEHEGGVAAAPSPTESTGCHQHGDHWHCDGPATSTAAASPDATPTGRGKCTWHETHWDCEKAAAPGSAEAAHDAQYEDSGECIIHVGHTHGDCSDAQLACGRVLLEDYNMSLHIGAIFIILVGSALGVLIPIVAGWARSGSQPLDAASWGRQLGFWPNVFFLARHFGTGIILSTAFVHLLYHGFVMFQNECVGEMSYEATAPAIAMAAAVVTAVLDFIGTRAADRKASRSSGMHLHTSPNLGSSDASSEPDVEKNTVPQPMVADACVHADALFQEEQGWQVIMLEAGIIFHSIMIGITLGAGSGAGWVTLLIVIVFHQFFEGAALGARMALLTWVSKLKIALMGLAFILITPIGIAIGIGIRQSFSQNGKASLLSVGILNSISAGILLYTAFKLVAGDFVDGPLRRAKWSKVIAAFSAVIAGLICMSVLAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1UZW6</accession>
    <name>K1UZW6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LAGLIDADG endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_08511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="6"/>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial DNA endonuclease involved in intron homing.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1UZW6"/>
    <dbReference type="STRING" id="1220162.K1UZW6"/>
    <dbReference type="eggNOG" id="ENOG502S3XQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_850433_0_0_1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051289">
        <property type="entry name" value="LAGLIDADG_Endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181">
        <property type="entry name" value="INTRON-ENCODED ENDONUCLEASE AI3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181:SF4">
        <property type="entry name" value="LAGLIDADG ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b/b6 N-terminal region profile" evidence="4">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="5">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38700" checksum="561D5D8231CBC41C" modified="2012-11-28" version="1">MYVLPYGQMSLWGATVITNMLSAIPWIGQDFVQLTILLLVQSLFIYLINYKNPIESLPTIGKVNTKALRGQKAREENDKLTFKKITSSFIAMFRGVVDGDGYIKLTKTIKGFISIELVISLDIRDKKLLEYLKSVLEVGRIYYHKNTVKYIIGRVDLQEVVFPLLLHYNIQFLTDTRREQFRQALNVLIKNIVLFEDLDKLSNTLVGLELPSTPAGYLNLPYFKNWVVGFTMTEGSFSIKASGELFFNLTQRSHDVLFEALKLLFNTTRKIDNSYRGYSKLSLSSVKDLRNVVNFFSYSDLHPLVGYKKLQYDKWLETMRGLPRFKNVKLPENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1U7</accession>
    <name>K1V1U7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L-serine ammonia-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07716</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1U7"/>
    <dbReference type="STRING" id="1220162.K1V1U7"/>
    <dbReference type="eggNOG" id="ENOG502QVSV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1U7"/>
    <dbReference type="OMA" id="SAAMGGC"/>
    <dbReference type="OrthoDB" id="192663at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="11">
        <location>
            <begin position="63"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="10">
        <location>
            <begin position="300"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC97919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="65550" checksum="541F5320421F76D2" modified="2012-11-28" version="1">MRPPASTATRGVKSSARQSDPASTIVPAPLHWGSGEDMPTELEIPPSKRAENAKPREGHAVISTFDLFSIGVGPSSSHTVGPMRAAKIFTYSLPPAMHDKIAHLKVSLHGSLAATGMGHMTPHAVLLGMMGEDPETVEVGRLSRVMDEVRAVGQIDLGLDGGHKRVKFDLEKDLTWHLNPLPSHPNGMVFTVFDDEGNMLATNEYFSIGGGFVVNRETQMDENMYYMQTRPKDAKDSRRHVDDEGDAEGGAGVLPSPSAEATDVLQKTDADVPESKGQPRDHKPRLLFASAEELYAICKEHNLTIAQVVWENERAFRSDAEIASGLLQLWQVMDECIRNGVTSTDKTLPGGLEVRRRAPGLYKRLQQGFYPAMAIPKPGGSDETALTKGEQRIGRTDHPLQLIPRHTRPVFPGIEYLSCMAIAVNEVNASGGRVVTAPTNGAAGVIPATLKYLVEYHSQQPERDVMTFLLTAAAIGMLFKRGATISAAEGGCMAEVGVACSMAAAGLAATLGAEPAVILQAAEIGIEHNLGLTCDPLGGLVQIPCIERNSLGAVKAVTAAQLAMAGGGEHTVSLDDAIEACRTTALDMHSHYKETSLGGLATATGVTKIPVSSPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V269</accession>
    <name>K1V269_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000399">
        <property type="protein sequence ID" value="EKC98019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V269"/>
    <dbReference type="FunCoup" id="K1V269">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V269"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="InParanoid" id="K1V269"/>
    <dbReference type="OMA" id="GWYHIPQ"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="45"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="702" mass="76488" checksum="9E03C3CCA6681B84" modified="2012-11-28" version="1">MPAARPRPSNNPERASKKAKPAPAINFPDAAARTALRQSYDASTPFKHTIVNNLLSDELLESVVEEAGSYGMRGEDSALPGWGWEQKQTDIYTIQQTPDLSSLDPNHLPEETLNGLPNITRLKNALYSDEFRQFVQDVTGCGPLSAKKNDGSVALYTKGSHLLLHDDSISTRVISYILYLPNSPNDAPPSEFSKPSECGKFQKGWDPKWGGSLELFPVENGEERGLPSAKAIARVPASWGQIVFFQVKPGRSYHSVEEVIVGDGRMRLGVSGWFHRPEKGEPGYGEFDEEKEMQALSSLAQITSAPMFPLVPYTTEPPLGLKPVHINFLKKFLKDSYLSREMLEKLAGQFVASSEAVLHHFLNPELAAKIKKECEEADKRDYPDRLIPKQECGEGDGWTLQGPSSKHRYASLTGNSEHMPALQSVLRDLIPSEAFRAWLSVVSSLMPMAYRSEARRFRRGLDYTLAAGEASAGEVRLDASLALTPWADVPPGSDEEEAILETGGWECYLPAPDADEDPAVYQSALAKKAKEALPNLEADMAVAEDKKAAEKAAEKPAEEKAAAAEPEAEAKTNGANGKTNGANGAEADGDAKMAAAAADDDKPKPSISMGGVELEFDPDQFSDSDFDSVGDDDEGPLLTMGPGFNRLSLVLRDPGVMRFVKYLSANAPGSRWDIDAEWEVGMMEEDEEEIVVVEGQGDECPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5H4</accession>
    <name>K1V5H4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inositolphosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5H4"/>
    <dbReference type="FunCoup" id="K1V5H4">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V5H4"/>
    <dbReference type="eggNOG" id="KOG3322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307212_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5H4"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="6">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="7">
        <location>
            <begin position="384"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="8">
        <location>
            <begin position="691"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="963" mass="107500" checksum="3DAC65A9DDD3D813" modified="2012-11-28" version="1">MKPRPRPGKPISKTVEMLRSNEQLKRAGKGKEKAVLRGLSDVVQALEVAALQTAAKVAANTSRAFQSLPRHLRRRAASHNPRRVPKYLKERAAAERRKAKLRARGNSKGQSRTQQLRLRQRGKAWLATHMFHAKRFHMTNVWGYRLPQTPTLKSFRSSYRAARRRVCLRDTSYFGVIELEAARESVVCAAAERVRFEDGSRSAHVNVYGRGQFPRGLIGPAELLWVPSETAPAAVWIRVHPSIFRETWDALASPSVRLRDLRTELESFDLMGPLSGSTILRSLPFSPSEPEENRQAIIDALTCDAAALPDGLTLNFTAVDPRLSACRLQLSKPAFKKAELDERRRQSGLPGKRLAPTDKDDYIPIMIIKRQVGTNEERNAMFHGFSIVFPKGWSMALLPSFAYCGAKLTGIFEAQVQHREAGVPSFPEHYGAVCQAATEYEDAQAKDAERRWIRKPPGKRIDFTALNVDHPFKPDWNAIVRRLSRSNDPAASLLSALNTIRNRRGMDPVPEESAASLFQTCVCHMEVDVLGRGSPLDMAMIYKVGAEQIIAAPIAQLVRRRSFPKSASSTGFVTPIKLALTAGVQRLDLSRDPREVWARVRSWQATPARLAQLGIMLAVWIYAIWIMTTPTFLWSLLIPAVFILACSFPITNQLIWPAAPIFTWVLLFFSARYIPTDSRPAIHVALLPALESVLYGANISDLQTRLTHPLLDVLAWLPYGVLHFALPFVVAVLLWLFGPKGSVQYWGKAFGFMNLFGVITQIPGYEIIHGLTPADYAMKGSPGGLLRIDRVFHSSGYTNAFGSAPLVFGAFPSLHSGSAVMEALFLAHFFPFLKPVYWTYVGILWWATMYLSHHYLVDLTGGACLSVLVFYLFMPAEFKDSDNIKWPNSAEYEMLNNGGGGANDVDFDEEIRRLEESEGIPPGDEESRIEVPESNLGPPSGAPRTKRSVSWGETQVLGEERPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7L6</accession>
    <name>K1V7L6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7L6"/>
    <dbReference type="HOGENOM" id="CLU_1116418_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7L6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="244" mass="26982" checksum="9828CB276EDD4071" modified="2012-11-28" version="1">MRLVQEQYCPNCGTRSVVESNIKVYRRTTPSCACSTTLVVSDTLFNVPETLPAHLDLQEVMLRTPEPTPWYPWGSNTFRRSRRAEASLASLPLTPKPFALDVPDAALPDLMAFHARYTDDPDWASSRLNLELVTMLFPFAHNAHEGHSDSLMVTESGAQWQGKSIGSHRLLTATSPPTALDPASCILSVVEGVVRPHTRASLLALRIVSTYPLPIELAPLHLYPHLWQAQAAWDFVQGSVTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V803</accession>
    <name>K1V803_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V803"/>
    <dbReference type="HOGENOM" id="CLU_377757_0_0_1"/>
    <dbReference type="InParanoid" id="K1V803"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="673" mass="76267" checksum="277F3001D93CD7CF" modified="2012-11-28" version="1">MDRLRSRPQLPLTFLRLSNDSAIPVFAGLCFLGTLFVLGTVGKLAFELVRGTRDPHRHLFGKTGVKPLFDEDLVFDIGISVFAHKPIDENKWPECSALGEVQWYRQLFREDGGHDSESEEELRLWMAYGEMSSVAYRRKGGMGGLSSCQILHVPETEELWSGVVAHSLTIRNSTVKATVDLDIPEKYLVLQAAQTAIGVMPEQNRRKDQGGDIPVESADNARKVFLESLSIRVPLLEMGSYFADVVKMVLLKRTSHMDYTGFTEWGERVLSDSEQTYDSMGHWYAGYAFGKPLFKEGSEDEYEWADWDRRRYPPFFTVPKPTPQEYTAIRHDSALRHSVHFSLSLIDEVRLGVLLAMEQPRDPWERKKYIQQAQDRLKLSHAMLGIGPRLGVGLGITISTLSEGARYAATILTVLYWATRRTATGISLSGLTFVVSGSILRDIVGTWDYYRYTLRDGIFWLAIWPILFFPAVLQLRLLLPFVAEKERENGPGEPTAFRIVQVPLTARERRSARLSPTWREIACCTALLACATYAAYFFPIRLIGSSHGEYWHDNYNAIFPGTRAWHKGNYGPYFLFRKRKLLPLALALVSAGQIAQLVMNYRSGTFAGNYALSCYLRAFSLLGLISPFLTGSSYFEGLYLSAVAQAGLVFAEAWQAWKYPRVEQEIEEEEMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V892</accession>
    <name>K1V892_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">porphobilinogen synthase</fullName>
            <ecNumber evidence="3">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_05498</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V892"/>
    <dbReference type="FunCoup" id="K1V892">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V892"/>
    <dbReference type="eggNOG" id="KOG2794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_1_1"/>
    <dbReference type="InParanoid" id="K1V892"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="10">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD00155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="35095" checksum="E8D29CE19D102DEC" modified="2012-11-28" version="1">MSNTDATHAGAYSRSVLHGGYHHPLARKYQNQGRNVTKDMFMYPIFISDDPDAEEVISSLPGQKRWGVNKLEGFLGPLVKSGLRSVILFGVPMKMKKLFLACDVCLCEYTSHGHCGIMSSLPNPVHSDQPTLDAEASAQRIAEVALAYAKAGAHCVAPSDMMDGRIRAIKTALMENGYGNRVTLMSYSAKFASSLYGPFREAAGSAPSSGNRKCYQLPPNARGLARRAIRDAAEGADILMVKPTLPYLDIVSDCAQLEPDHPVAVYQVSGEYAMIVAGAEKGIYDLKQMAFETVESFVRAGASIILSYFTPDFLVWLDEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8L2</accession>
    <name>K1V8L2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8L2"/>
    <dbReference type="FunCoup" id="K1V8L2">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8L2"/>
    <dbReference type="eggNOG" id="KOG0688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="InParanoid" id="K1V8L2"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000002">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="439" mass="49039" checksum="8EE18FAF2ABC9E45" modified="2012-11-28" version="1">MSTAEETDQAIEIWRYRKMLNMLAASRGAGTSCITLILPPRSQISQASNMLTTEYGTASNIKSRVNRLSVLSAITSTQQKLKLYNRVPDNGLCVFVGTVLNEEGKEKKISFALEPFKPINTSLYMCDSRFHVEALEELLETDSKWGFIIMDGNGSLFGTLSGNTREVLYKFNVDLPKKHGRGGQSALRFSRLREEARRNYVRKVAELAVQHFITNDKVNVAGLVLAGSAELKTDLSSSDLFDGRLLAKVVKVVDVSYGGENGFNQAIELAADSLANVKFVQEKKLIQKYFDEIALDTGKYCFGISDTLKALDMGAVETLIVWEQLDTIRNTLRNAAGEEVVVFSKPDDKDREQFIDKSTGNEMEMVKDPQPLLEWFAEEYKNFGATLEFVTNKSQEGSQFVKGFGGIGGLLRYKVAFEDMGDFEDFDDEFYGSDEDSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9C3</accession>
    <name>K1V9C3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9C3"/>
    <dbReference type="STRING" id="1220162.K1V9C3"/>
    <dbReference type="eggNOG" id="ENOG502QURC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871589_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9C3"/>
    <dbReference type="OMA" id="HVIQHDG"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="344" mass="38641" checksum="4BAE1AE98B8B92E5" modified="2012-11-28" version="1">MGLFSKLDKAFKDIQQQAQQQAQQSQAAFRPPPPGGGSRNCPVLASSYLTNADPSNGRPALHPCQHPYRGAIPPGSLCYTLEHPDPQYDAATRFFLTCVPDPIGLAYHALNFARLKLVDPQYPTNWAWKHITIEITDEKGPGLAWTASGKCTICISWITSQMNDYNAGKKTLEACAFEFKGVIMHELVHVIQHDGRGSSPSWLTESVADYIRMQTDLGPPHWRKPGQGKRDEGWKDGYDAGANFLAWLTGETKDDLVHIAQTASVQQPTPTGPPGAHQSQYPPNEQYPPRVPCRPGKQRRGPFPNLVRHMDYRLANERYNEGWWQEMAGAPLPQLWREYLDYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9T1</accession>
    <name>K1V9T1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9T1"/>
    <dbReference type="STRING" id="1220162.K1V9T1"/>
    <dbReference type="eggNOG" id="ENOG502QSJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016583_0_1_1"/>
    <dbReference type="InParanoid" id="K1V9T1"/>
    <dbReference type="OMA" id="LESHTGM"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="406"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="568" mass="60081" checksum="82D033C6E2B180F7" modified="2012-11-28" version="1">MASSNGVMSAPQPPRSAGTHHPRVILAGSSARILCVADIRGDYHELNRLIREHEATAVIHTGDFGFLNADSLERMGDNSSIHFPLSQFPHLLSGAITFPVPVFTVWGLIEDVRIVEKFRTGEYEVNNLTVIDEASSALIEASGIKLRLFGLGGAVAMHKLFRYPASLNDYAIYGDFDSYRQKLVLARDNFVSVGDAELTGSEQQHALLKKVLGMVQKIPTSEDNAWTNTWHWVLTDAMCGHLLLEINDGRVSAETRSNGLNFAHRANQAQQPPTAPVASGAAAPLAQSRPEKPIVGAAGAKSVPPKPIGTNAAPSTSAAKSSGAGPKMTGSPTQAATRGLRPVKDAKSEKGELKPTDRSSCAAGKAKASPSSTPVPLPKEKKEKTNGEKPVDGGEESEGKATPKRFSLYLKGLPTPTSEAEVKAFMGPAGEKAIGIKLVYDHMRRQKNFAYVDYANEQEMQDALKLAPVGVSFKHREIANSSQQNIRDSPVTVELSNPPVRGLAAERGRGSRAGSRRAGRGGSAGSKEAFKEGKDGGKSETPKPEGGKEASGAGSGAGAAAGGKSEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA97</accession>
    <name>K1VA97_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maleylacetate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_08089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA97"/>
    <dbReference type="FunCoup" id="K1VA97">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VA97"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_1_1"/>
    <dbReference type="InParanoid" id="K1VA97"/>
    <dbReference type="OMA" id="HAMSHQV"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF102">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="4">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="184"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="373" mass="39690" checksum="42B539933EAC5C43" modified="2012-11-28" version="1">MKPFTFEAHIPRTVFGSGTLDKIPEEIERLGAQRVLLVTENTDRQRALADKVKGLLGDKVVGIWTIALAAIGLQLHEGSCTDAVMHTPEEVTLKALEQAKSVNADCYVSLGGGSTIGLGKALTIRTGGKHLAVPTTYAGSEATPVLGETVNKVKTTRSDPKILPNTIVYDVDLTLSLPQQLTYTSGINAMAHCVEALWSVGNNPVIDGIACSGIQDLASALRKLKDTPNDMDARGKATSGAFVAGVCLAHVPMAIHHKLCHTLGGSFGLPHSETHTVILPHAIAYNAKAAPEAMEKIKRALGTDKDAATGVYDLEKELGTVTSLKELGMKKEDLEKAAEIACKAQYPNPEPLEKGKLLQLLENAWEGKPPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAK5</accession>
    <name>K1VAK5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAK5"/>
    <dbReference type="STRING" id="1220162.K1VAK5"/>
    <dbReference type="eggNOG" id="ENOG502S0PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_1_3_1"/>
    <dbReference type="InParanoid" id="K1VAK5"/>
    <dbReference type="OMA" id="ELRPQYW"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="278" mass="31849" checksum="DCF48AAD6FFB5277" modified="2012-11-28" version="1">MTQLSPEALNELARRDVATPITGDELQTALASPPFVDGGLINLRDLGLVPNCPIPAGKFFRCGQIVESDQANQWIRDHVKVIVDLRKAGERKRSPDPEIEGVDNIWYDPEQDGWKAQKLLIEDFERENGSAIGWAEQYVLVLRYYHRTFRAALEHIRDHPEDPMLFHCSAGRDRTGIFAWILEYLAGTPEKDRTFDYLLTRIGIEPARLMFENHFKTSWGITDLTNKGYLNAMTLSPDCFTLVTEEVTKEYGGWDEYLEKKLGFSKEDLDKIRANLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBZ1</accession>
    <name>K1VBZ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_07349</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBZ1"/>
    <dbReference type="STRING" id="1220162.K1VBZ1"/>
    <dbReference type="eggNOG" id="ENOG502SCC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663953_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBZ1"/>
    <dbReference type="OMA" id="DQDWKGT"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="28"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="254"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKC98335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="362" mass="38572" checksum="E816FBBE16C4ADFA" modified="2012-11-28" version="1">MDSPFLTNKPLDDEDGTLVLADLSIADEESFDIPAPPRGLPRGAAASTSASSSIASSSSRQPPVAPPSAARPPSKPRFSLFAPGMAEVTPAHTSTLRPAARPPLDPPSERSERSQPSTSQAPERPSESERRPPTFAWDETVQEVEEVDEEERREDAEPERREDPQTAEARDESLRTSLAELKRINTVFDTLMGALEEGRAHNTTSALLDDYVKLLGQAEHTRQLVMNEKWTGAEDDAAALQEEADRAAERAAAEEARRAAEAEEAARRERERQAAAEREAAAKARSAAATRGRPGVRPTRGGLRGRGSSIPAPSRSRPTSAAGTAAGTTAGGGHARTTSGFRRPASGLGGRYANVPSSGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCG3</accession>
    <name>K1VCG3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCG3"/>
    <dbReference type="STRING" id="1220162.K1VCG3"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074424_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCG3"/>
    <dbReference type="OMA" id="WPMLALP"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="324" mass="36059" checksum="A966F930B7A8D3AA" modified="2012-11-28" version="1">MEEDQHTPTTRAPPPNPPPTTVNTVFSTPTPEEQEAPIPPFLAKIRAAHAARSPTSPVAVEDGAPPNALYLPPPAAPDVQEDLVPPENFGAVTQGVYRCGFPKKRNFKFLETLQLKTVLTLVLEDYPEANLEWCQQQDIQFMQFGIPGNKEPFDNIPEDVIASALVAILDRRNHPILIHCNKGKHRTGCLIGCIRRLQSWSLTSIFDDRYRRFSAPKSRAVDQQFIDLFDLAPVWEGVLTFGGGLANLPDWPMLALPLPLQALREQERSQKARKGTREHKEHHKEHKERENGNSNGVNGTGRIEHVPRAGLITAPNDAVEIAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD75</accession>
    <name>K1VD75_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD75"/>
    <dbReference type="STRING" id="1220162.K1VD75"/>
    <dbReference type="HOGENOM" id="CLU_943946_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD75"/>
    <dbReference type="OMA" id="IHAMEIN"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="295" mass="32942" checksum="92F6389B72E7D237" modified="2012-11-28" version="1">MFGDDGLERLNKTLRQQLSDRGEHARCALLTTDARLSVLEGEVRKQETALAEARRRADDERQEREQIEEKYTRTEGERNELKQGSNLAAQLSAEKEATTRLEKETRRLEYELESNALAGNCATQSGEAKLTARIRALESEVKSKEAECARAWAEVKASALAASTSTATPPRPTPPQSRRTSTSADELELANLRQMLDSKSTELSKAQEQVANLRRQCDKAVNEKMALEKRSAREIEELQSQNEDMGYEIQALRGDKPSPEVEKLKTKLAEATEKVAIEIGLLHPKALPSAIVAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDC6</accession>
    <name>K1VDC6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U3 small nucleolar RNA-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDC6"/>
    <dbReference type="FunCoup" id="K1VDC6">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VDC6"/>
    <dbReference type="eggNOG" id="KOG2048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002392_2_0_1"/>
    <dbReference type="InParanoid" id="K1VDC6"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="76897" checksum="5222B2F323A74879" modified="2012-11-28" version="1">MPAPTQAPTVPLHRIRFFDHTPSPITALSFAPIPLPPARDPSAAPTSTKGKAREDGNPELGVLVVARENGEVEIWQYVPADEGGMGNWVLSKNFHEKSYSVPRVEDLRLFTAGSDSNELTERCLETGRVLQTYPIPSPPLWSLSVSPTHQLLCLTTNSPNLHFVSIPPPLLGNTATPLEPAPAHLLRSDALPSRTRTVSVAWGIPKLVEGEDGWTWRDSYLITGNSDSSFRRWDLPPPSAAGTPSGRVTLKSRAVVEKVSKGKKAGQKGTIVWGVGVLPDGTIVTSDSLGSVTFWDPSSMAQRQSFRSHKADGMCLVIGPGGRTVFTSGPDQRVCQFTAVPQQKGGVQWALTSTKRVHSHDVRALAIFPPYVPLAANTKIPPTPINPGLAPILASGGWDMAPVLTSAAPADIMADKLKNPLAKNKNRQRVTFEEAYSRKLSAFGGERGASRISVAREARLVLGRKDRSVGVWRVLEDEGGWEKVLEMELKLRTNLISSSISEDGQWLAVSDLYETKLFRLLDTGSAVRPHRIRSFATDLASAPELKELKLGQKGCGASALLFTPDSGRLVMALAASANVVVLELPEVDEGDEVEVARVFPPQHKLEGGRSIRRRRRQKAAHRLDMDVEMDSSSGSESEEEDKAPETQPWVTGLSCSLDGQYLATSDTGGKVHETNVSSLPASSSGSLSSFRVSGLRILSPTRSRVEDQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDP4</accession>
    <name>K1VDP4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pirin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDP4"/>
    <dbReference type="STRING" id="1220162.K1VDP4"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_772052_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDP4"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053186">
        <property type="entry name" value="QDO-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43594">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43594:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE PA2418-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin C-terminal" evidence="1">
        <location>
            <begin position="218"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="359" mass="39683" checksum="C9DEB667D001332B" modified="2012-11-28" version="1">MALRPTRLLRNKLGTVAPLEAKWKGVGPFLYVNHHVDHYPAGTETLGPDPKLLKGHNPGWDFENDFGWRTYMATGPVPGFPALVVHVEWRLTSGTRIAASKPCRSCAKASWTTATALVPVHGMGTATSKPERVGDVSVLRKPKADSRYQLWLNLPKKNKFAPPEFRMLWAEEIPKIEKDNGRVRISVMAGEYEGHVPPSAPKNSWANEPGSDLAIWLFDLKAGGKVTIPPPKGADTLRTLYVHGKGARVRLGDQEVKENEAFEASPGNSAEHAIPVTAETDSTILLLQARDIGEPVVVKGPFVMNTEDEIKQAYADYKKSHFGWEEKWDTSAPVYPKDAGRFAYFGDKKVYPPGKTPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDX3</accession>
    <name>K1VDX3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDX3"/>
    <dbReference type="HOGENOM" id="CLU_3070364_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDX3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="53" mass="5533" checksum="1D7FDC8EEB3C0AE0" modified="2012-11-28" version="1">MPLLETISVVAVLIAVTGTVGTVTISFVWLDPSLGHPLPAGAGYADRDWSPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDX6</accession>
    <name>K1VDX6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDX6"/>
    <dbReference type="eggNOG" id="ENOG502SBFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035170_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDX6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23202:SF124">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23202">
        <property type="entry name" value="WASP INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854100" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="54908" checksum="6F42B38F23642D1B" modified="2012-11-28" version="1">MKLSAAITALAAFAATATAVPTSISARGGDNGGGTCENPGRTVWIVTETNDPVGDYYGWGTAALQDIRHRLTSESEATASNKADRIAVTSLGDVDATQFYELMPLSDPENPQFDIAMENRTNLIHKGWSIEFAYDHAWKSMNDKFHVHKGLGCFIAVTDCILRDESVEKFLQQITEARQQGYRTHLLAVRGERSHPVRYSMEHPDNFLAQIGQGFNNWFAKAFPDKAAVSHDETTKRIMDAVRAAGGTVVRMESEQNAKDWVNELFKNGLTDLDGKCVDTGDNENTDTGGGELVPDQVSHGLCSKNAETVFTYSPKKDEHVEVTVTLTSTESPVNIEATLLNTVSGETKFVTINKGNIKGILEGSGKQGESVKVTLKTSNADSNKCEYSVSLKTSVPQPPPTSSATASSASAPPPTSSATASSVLAPPPTSSATASSASAPPPTSSATASSASAPPPSSATPSPSATPSECPVPEVPTTTITSTVVETVTGSAAPQPTNSYCVCKCDVKGAKPWPKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF27</accession>
    <name>K1VF27_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF27"/>
    <dbReference type="HOGENOM" id="CLU_1696751_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF27"/>
    <dbReference type="OrthoDB" id="10545321at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="182" mass="20804" checksum="2968AFC94B66C838" modified="2012-11-28" version="1">MLHTAHRGAIHYARFKGRPTPYPSPSSLRSHPAQPHMSPPTQVTYRSTFEPFTTDGELAALSLKLKAEYMYPEAESWRLSNNVSSDVWSQAEPRLNPTLMGSSQHFWFTTFLPRIAFLTHRRVTSEEVDGRLGQLITNMLYMFHVHVTDPQTGSRYAVGQEILEAVRAIRDTRAIPWSDEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFF9</accession>
    <name>K1VFF9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFF9"/>
    <dbReference type="STRING" id="1220162.K1VFF9"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1240904_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFF9"/>
    <dbReference type="OMA" id="RLWNARY"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="223" mass="24326" checksum="0CD1AFD74763DF2B" modified="2012-11-28" version="1">MPSRPLPLNRPLDEDPVSRSATPVTNTPPRAHGTPGTPTHQHTDSAGGGPSSNDVEKISTIESITLEYSYLLSSQLEAMRQHYEAQMAEQASQIAQLREETARAKSVQDQVSAAEQQRAAAEAAREKAERKAEKALEISRALQQNLGSERAMSQGLSHKITKLTSDLENVRAQRDAKSKEVEELNDTVRDLMFTLEAGMKLQAEGEEGGDLVVKGGKGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFI6</accession>
    <name>K1VFI6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000275">
        <property type="protein sequence ID" value="EKD02835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFI6"/>
    <dbReference type="STRING" id="1220162.K1VFI6"/>
    <dbReference type="eggNOG" id="ENOG502SBJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1732785_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFI6"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16807" checksum="6CDF9DC2C1EF976B" modified="2012-11-28" version="1">MPNILTGVVTKTGAMAKTITVTIGSKRPHPKLLKMMFKTHKMLVHDEEEKLRPFISPVTADVPSSTADTLPEGRVGDHVTIIHGRPISKRKHFTLRSIDFRPELEHIPAAPEIERISRRANGIMEQMRREKAKLDAAKAAEAEAEAKTTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFR9</accession>
    <name>K1VFR9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFR9"/>
    <dbReference type="STRING" id="1220162.K1VFR9"/>
    <dbReference type="HOGENOM" id="CLU_1797811_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFR9"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="144" mass="15690" checksum="5F8C90E4B347999C" modified="2012-11-28" version="1">MRLAHIPAGPEAIPALKKDHIHMSLLNPRHDQLVHLHLDQIHASGRRSKILDVGTGTGSWAISLARRQPYSDVIGIDIAWDQFEGTRLPHGNADFHTVDVTLPLPWGDETFEHADGGAELRGHGAQPDASAQATRAACPRRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG02</accession>
    <name>K1VG02_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG02"/>
    <dbReference type="STRING" id="1220162.K1VG02"/>
    <dbReference type="eggNOG" id="ENOG502S45T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067862_2_0_1"/>
    <dbReference type="InParanoid" id="K1VG02"/>
    <dbReference type="OMA" id="MLYRANT"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="201" mass="21953" checksum="31AD88EB15E983AF" modified="2012-11-28" version="1">MAYEPEDPYYETVVDEHGRTKRTKRDVPPGLSKRDAKALRKIRRRAHYLDKGINLCGFRVGWTFFIVKPARKLDIPDSLVTHMLFNNAVSAGVGLVPLVGDVALAVWKANWRNAALLEEFLVKRGAQNLADSLSNDPAHGHQVAHAALAPSAHATPASSNPQLASDVLATGGHPAHMHEQTPLNQPAQPAPAAKKGWFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG50</accession>
    <name>K1VG50_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG50"/>
    <dbReference type="HOGENOM" id="CLU_861033_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG50"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="312" mass="35330" checksum="9136A05FD221F78E" modified="2012-11-28" version="1">MTVSIDYFGFPHIFGLVITHCDFDTQNTLRLLSSDAKAVVDRVQCRHLSAYLIEGRWSLIRSWWDLPGGDCRGASAPPLLTTWNGILPTSASLDKALAFALDNTCYIRIDDEKILQMYCEASMRANGLGSDRVLGPPHFLKRLQPDSVLALSHSTSTETPSPRFFPHSPHEPYYSKPFIRLPPVKEVHVKYVHAHLECPCNPPKRILHSAQKLRMSVTEDAGSMAFCGYVRNLFTPTVERLELFVSHLSTAVTLLEHIVSETRHRDLHVLVICRNSNAQEALEQLAVQWTERLGCEVTAQWYEGSRYEGTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGA9</accession>
    <name>K1VGA9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGA9"/>
    <dbReference type="STRING" id="1220162.K1VGA9"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_1_1"/>
    <dbReference type="InParanoid" id="K1VGA9"/>
    <dbReference type="OMA" id="MEQPMAL"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="220" mass="24131" checksum="34E07FC5AFC279EE" modified="2012-11-28" version="1">MSAYGAIQVKPLDADLPTYSYTLPNGELLTTHAVHNGNAPAALIAYLHDVFSEELEEGKTYPQEGPMTLDEFKNYFFGATTIIGVLSPAGTDPKAVQTLEDAHAGRDWKECVAGCYYIKPNYPGRSSHQNCNAGFLVPNSQRGKKIGNALAESYTHYAPALGYRGSVFNLVYENNVASLRLWEKLGFTKVGVIPGAGRLKTGNGDEEKYYDAHIIYKSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGD1</accession>
    <name>K1VGD1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Meiotic recombination-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGD1"/>
    <dbReference type="STRING" id="1220162.K1VGD1"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352733_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGD1"/>
    <dbReference type="OMA" id="ETHASIH"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="6">
        <location>
            <begin position="271"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="594"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="838" mass="93312" checksum="52F07DCFBFD9864F" modified="2012-11-28" version="1">MDRKGKRPARELDGVGSPGPSTLARRRVEPPATPESMVAGPSRFQGALRESSSPTGSQRVQPPTRSSRDDATEPLRPVPEQPDDDEDERPADDSYTVLEDTKDTWAWDLAVLLLEQFRPQEVVLSTGAPDKLTNAVEEFSYPATKLVLLPAKKFQHAAALYNVSAIRLPREQRAVSDWSGSQGDPALLDEESVDFAHEELDHGMGKMRLSLLKMGCRVNVHAPFAVGFVARADELGEDALAFNLTSVVSMDISLAIFDIEAHAYMHSKQHMAGLSLYSLLNTTVTPLGRKLLHTWLLRPLISIPRIKERHDAVEAFSATEHGQLRKLVKKELKGVKNPVKFLHMIKSGRASYRHWKDLVDTLNAAEAISEALVVVGLQTYLKVIKQLAGGLTEAVKLFHLDTIDWDSSRDEGRVCIRSQIDEELDQWREDYAGELSCSSAKLMRRSGATARLVPRVSPDFCTTINVIYLPQLGCMVTAHDVKDLDAVSPDWEQQFSTDEVIYYKTPEMHRLDEHFDREIEWVQKLAERIDQVEENILGIGDTLAELDCLLAFADASDRLDLRRPVMKEEPILRIRKGIHPLYAVNCHTGYIDNDTQMIVTGANGSGKSAYGKQVALITYMAHIGCFVPAQSAEIGLCDKSCLGVHDRPKPGIASSAWRYKPFSHRTRRVRERSASWRPDASAKGDSPKNSRPDSLSFLDESLPTIYCHMKSVLVEGAKQLTYLYNECLSKFQITKLIDDGLSERDLQELEDAEDLAKRFLRWDLGASDGTGVLADLRELLGDMELDVESEAEAEIGMGSGTTLLEHRLSTTRSELSSVRAETLVNDENAGFPMDAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGH5</accession>
    <name>K1VGH5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000262">
        <property type="protein sequence ID" value="EKD03200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGH5"/>
    <dbReference type="STRING" id="1220162.K1VGH5"/>
    <dbReference type="eggNOG" id="ENOG502RG69">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_2_1"/>
    <dbReference type="InParanoid" id="K1VGH5"/>
    <dbReference type="OMA" id="PHEMFTA"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="302" mass="34142" checksum="658ADF50FC488CF3" modified="2012-11-28" version="1">MAAPKKVVVFGVTGNQGASVARALLEHKDKWEVWGVTRNPDSGSSKRKLLKLIKGDLDDPQSYAKGLEGAYASFVNANFWIAYKGNNSDEAAEIEFTQSSSAVEASAKAGVKHVVYSTLESYKPRQDLPHFDAKARVTEYMKKNNIPGTQLYTSFFFQNLGMAKWDEGKDGKRILHLELPDDAQMPGFSVDDVGYWVRAALEDPQKWIGKDMEACTEVVSPKRICEVLTQLSGKQWDTQHWSRDAFMEHKNKMDGELWLNYFAFANGEMKRDVEASRKIAPQAKDFTQWLKDSPKVQEHFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH36</accession>
    <name>K1VH36_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH36"/>
    <dbReference type="STRING" id="1220162.K1VH36"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309535_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH36"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="105136" checksum="72B50D472DD5A249" modified="2012-11-28" version="1">MPRTTVPRSTACPSTACTADTAADTEQALGGGMGSVPREAGYGEDTAWLSGATARGSAKGAASPCEGVSEELRARPSSTKGAEPNCGQAQGGLDPSQPSQPSQPSQRRYSGCAAWPDCALQPPPNLAQHAQPTHTQTLQSSIPPPSSRQHPPPPTPFPTQHHPPSFATAHLLTHLFLKRNTSHLVRRASTSDLATFLPSQGLGTHPMRLHQPGGLNGVEVEGSCPPSPGQASSPSSSSRINSSQHSASTTRRRLSLTVPRPRTGSPADSPTSARVPWSPVHRTAADSPVPRRGSTLPPPPAEHNFKQNKSDGEDDYDPKRTRRSLHHSSRSRPHLWQNNSHVWHSVSPNISPVPPSPDPNNILPLASVASQSDGQDSTGESSPRTSSSSGQFGWSGDSEDYSEEDDILREKAAANSWWGSHFDDTTRHLLPRSLGFSIPFAPRTPRRLFRSVRSVFPPYGNTPQHPGLSRRKSRRRSDSQGPIWKRVSSFAHNEPWGLALFVVAFIVFAVVMTGTIKYILDPDKRALPWRDYCQEDYPTLFSLQDPNSPLFPADQTHRSLAGSDLVLAPITPGSAQWPWPGSSHNPYTTDFAGEALDSIEPTTVFLGVFTVDHSVDRRNVIRETYGSHPKSLKPGSEGVRLRFIMGRPSPEWAERVAAENKKHGDIVILDIDENMNNGKTYHYFSWAAEHATVPAYEYPTVGQAIYKGEKRPAYVAKADDDAFIVLSELERHLRASPRKLTHWGYLVNNWFMAGECYAVSLDLAEYISTSPEVAQHVNGKEDKRMSQWLHAHPEREKITWVSEKTWIYDHPRAPTVYSHGFLFPSEVAMTRKRKAEGWKPPHSAWQWSNGPASYSTVSRFGDTYAPPAPFTPEQQVEALVEGSELSLLRDAPRPRTAAQRKEQKLQIDAAMARRPTRRERFLGDERERGGTVIVHFIKKNEWFWETAAALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHI4</accession>
    <name>K1VHI4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHI4"/>
    <dbReference type="FunCoup" id="K1VHI4">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHI4"/>
    <dbReference type="eggNOG" id="KOG0923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_7_0_1"/>
    <dbReference type="InParanoid" id="K1VHI4"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="451"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="640"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1092" mass="123979" checksum="025B9875EF5318D5" modified="2012-11-28" version="1">MADLRQFIGDNLVRVSGAPSTSHSKLTSQLLGSADSAVTDFVHSAGKNKQAESSADMVALSARTPGDLYNQLLAAGLSESPDTQAFATQVHGLVPRKTKTKKPKVAPTVNTQKFTFVTEEEERTSKKKKSKSKDKDREVASHKLERSSRKRDTEGNWDSDPEDLEPEPPKRARFDSPVRDEEPPEPEETEEERLERERLEDLAERDAFAERMKNKDQDRTKKIVQDRSNEGTEEAARRQLFAEDAEARREVMPDLRERSRQSYLQKREEQRLDLLKLEVEDEKILFRGQKLSKREIEEHERKIELIKILEERKKIDDGTDGYMLPEDYITEQGRLDSKKKKNALYQRYEERDKNKEAFATDVDTWEESQRYRTDFVTGALDKEVVDENDGYDYVFDESQGIQFLQEGGLDGTLNPEAEALLAQVEEAEKKHQSIQDTRKSLPVYEFRDELLEAIAEHQVLIVVAETGSGKTTQLPQYLHEAGYTAGGMKVGCTQPRRVAAMSVAARVAEEVGCRLGQEVGYSIRFEDMTSDKTVLKYMTDGMLLREFLTDPELSTYSALVIDEAHERTLSTDILFGLIKDIARFRPELKLLISSATLNAQKFSQFFDDAPIFDIPGRRFPVDMFYTQQPEANYIHAAVTTILQIHTTQPKGDILLFLTGQDEIEACEENLKETMYALGDKVPELIIAPIYANLPSEMQTKIFEPTPEGARKVVLATNIAETSITIDGVVYVIDPGFVKQNNYNPKTGMSSLVVEPISRASANQRAGRAGRVGPGKAFRLYTKWAYKNELLEDTIPEIQRTNLGMVVLMLKSLGINDILNFEFLDKPPAETIIRSFEMLYALGALNHKGELTRLGRRMAEFPVDPMLSKAIINSENFKCTHEVLIIISMLQESGSLLYRPKDKRVHADKAHKNFQKPGGDHFTLLNIFEQWAEAGYGQQFCYENFVQYKSLCRVRDIRDQLASLCDRVEVVIESCPNDVVPVQKAITAGYFYNTARLDKGGGYKTTKNNHTVYMHPSSGLIGMQPPPRFILYYELVLTSKEYMRQCMPIEGEWLYELAPHYFNRGDVQKMMGSASSVKMPKQIKPAPGPQDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI80</accession>
    <name>K1VI80_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI80"/>
    <dbReference type="STRING" id="1220162.K1VI80"/>
    <dbReference type="eggNOG" id="KOG4388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003590_2_0_1"/>
    <dbReference type="InParanoid" id="K1VI80"/>
    <dbReference type="OMA" id="WVQMRII"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="297"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="552"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="939" mass="104042" checksum="FAD7B093E9AE2A4D" modified="2012-11-28" version="1">MIGQLLGRPSPALRRGQVFLILFFWIWRLYKGDGSYMRSTPTGYNRSMPSHRVRPVAHLAPTIAVPAKVWWRRVWSFLVARRTGTRWMTNINERLKYFTPYQLILGTMTLVYALRHADDLLGIGPPEPHANMYSRSYYRATYINTALDAGFSTAMSIRPKWLRDISSLLFAGYYLIYSNEADEVLRKYRALCSVEMLRTTWEKTFINPYLRFAMKMMLPKLPIVKYVMIPRPPGSRENLPAVKAMFFFDGTEEELAKATELVIDYPGGGFISMGPECHEERLRCWAKRTGKPVEGIDAYVTINQTGGECLGIKSGKLRIVLTGDSAGGNICTTITNRILEHGAHVPRPVAIILSYPALDFNFTSFMSPDNLKVLKTEQSETHIPGLLAGKDHMRHAAPLSVVDDVKPRRPTHRSSKSWANKLGMSMAMTPSAESPSHRRSRSTSRSRATSPHPKRSLTTRNSGWFANREGRTSFTKEEDSEDSDGESWASADSRRDADKSLRDRVKTPGPHMDERFKGGILEAAGEELVVDPLRPKRAPLGTRLTMTSRVGYFQDRVITPSMMRAMAILYVGPQQCPDFGSDYYISPILTPPHLLAHFPPVYMICGERDPFVDDTVLFAGKLREAKRARRATAQKAAATSKDGVPDPILRESDDDWVQMRIIEGWGHGFMQMSALMKEVAPVLIEMADWIDESFQRADLIDKDEASAAENGNAQDLPSPVRSRLVKPGTHYPKIPANERLGDADLGGLDFAESGEDEGMISFTPKTKSKKRTPPPSQFISMPRRSSKETLIPRNNSAPRFDDDVTSIASAETAEVQTPKTFTFDAPQPRGSGAFALFGRSSNSTPRAAPTGASALYGAGTFPRRSDSVGSSGSRASVSLNGGPAALQRAAAAAARAASPALQAAGIVPQKVSNLSGAELMRRRRAEAVLGMEDEKDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ50</accession>
    <name>K1VJ50_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ50"/>
    <dbReference type="HOGENOM" id="CLU_2016820_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ50"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852158" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="123" mass="13504" checksum="3C5F499791254538" modified="2012-11-28" version="1">MLQLTYLSVLFATLAMADFKLVPFPTRVLIHPAGQPNYCINYVTTKNTPPYEFKLRMAARTGTATSTPPKNGDLASITECSDGVNEWQKFYHLTTDGRGSLTVGPTETRKLPLHSALTSSDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ67</accession>
    <name>K1VJ67_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ67"/>
    <dbReference type="FunCoup" id="K1VJ67">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ67"/>
    <dbReference type="eggNOG" id="KOG3440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115154_1_0_1"/>
    <dbReference type="InParanoid" id="K1VJ67"/>
    <dbReference type="OMA" id="PLAQWYT"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="157" mass="18657" checksum="4FFEFD18CEE5BB3F" modified="2012-11-28" version="1">MPSLYKALIPISKAYVNAAGYRKVGLKYDDLIIEERRDVEKVRRNRRFGQGKNRGSAKWSTHSECERRRMGMRTQRHHLAQLPARKAISRLPAIEGYDRAYRFRVAFQQDLMRRPLPKEQWLKPEDDVRYLTPYIKQVAKEDKERADWDSVTVKDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ95</accession>
    <name>K1VJ95_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ95"/>
    <dbReference type="STRING" id="1220162.K1VJ95"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="InParanoid" id="K1VJ95"/>
    <dbReference type="OMA" id="IWHSYER"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="147"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="729" mass="79716" checksum="18CA27F1225E850D" modified="2012-11-28" version="1">MTMTPFPDNLDLNRQGEAIPGTESADASAFYKNSIWGPKELRVAPDGTTQPGSLYQIFEQSVARHPNQAMFRSRILNPATKPGEAPSYSTKTQDTTYGQVQQRRNAVGSALLNLERLGRLRDPNVPADLPSPPEIKQDGIPSYGDRLNAGARRGWAVGIWSGNREEWQIADLACQAYGLISVSLYETLGPDTAEYITNHCPLPLIFSSSNHLADLLRIAPRCPSLRVIVTMDTLAPAERDVLTQWAGSLGILLLDQVEMEQWGVQPGNFITPGPPKGEEQLDIDRIVTISYTSGTTGNPKGVILTNWNMTSATVSNSLGVSPFFEKEGWKFFSYLPLSHVYERFLQVLVIYGNGIICLTTGNTLQLLEDAQIFKPNFFPGVPRVWNRINAAVMIQMKEPGLKGALLRKAVQTKLANFRATGAITHRLYDTLVFRKLRALTGGEVVYMSSGAAPLSASVHEMLKICFSCDVIQGYGLTETVGTATKGIPEDPNAIGTTGQIQPCNEIKLVDVAEMGYTHKDSPNPRGEVCIRGTNIFKGYLHDPENTAKTIDPDGWMHTGDIGEIDAAGRLKIVDRVKNVVKLSQGEYVALEKVEGVYALNPIYATLVVHGDSLRSSLVAIAVLEPALASKLVSDVLGEKIDPTDVDALDRAVKDKKVRAKLVEGFARVAKQNKLNGFEFIKGVFPTVQPFPEHLLTPTQKVKRNVAAKHFGAEIDALYDEIEGSGHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJE8</accession>
    <name>K1VJE8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJE8"/>
    <dbReference type="FunCoup" id="K1VJE8">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJE8"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="InParanoid" id="K1VJE8"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="249"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="313"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="560" mass="62337" checksum="23E6A13A36235494" modified="2012-11-28" version="1">MEYEPDAAGQESYILCADCGTVISSANGSGLCVGCLRNSVDITDGIPKESVVNFCKGCERFLSPPNTWVACQPESRELLAICLKKIAKPLLKVRLIDAQFIWTEPHSRRIKLKITIQKEVLANTVLQQTFVLTLVVQTGQCPACTRLAAKNTWKASVQVRQKVTHKRTFLFLEQLILKHNAHKDCTNINEKRDGLDFFYTERNNAIKMVEFLASVVPVRVKGSEQLISQDTHNGTANYKFTYSVEIVPICKDDLVCIPKNLARQWGNISQLTICSRVGNTLHLLDPLTLQQTDVTAPVYWRQPFESLAQTSDLVEFVVLDIEPTGVQRGRWVLADAQITRASGSGQAADADGMGDDGIYHVRTHLGAILQPGDTVLGYDLTHTNFNNDAFEGIDPHRIPHVILVKKTYPNRRKKNRPRNWKLKSIAKEAEEDTTVGRGALGRRGGVDQKNVERDYELFLRDLEEDKEMRAAVNLYRADDAQDMEDDDGDVAMGGQKGSGMRGGKRRGGAAAQAAAAMEVEDGNIADEDDDGTEEEDFPEIELDELLENFDDMAIEGEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJG8</accession>
    <name>K1VJG8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJG8"/>
    <dbReference type="FunCoup" id="K1VJG8">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJG8"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="InParanoid" id="K1VJG8"/>
    <dbReference type="OMA" id="WTYFTST"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="290" mass="33251" checksum="027D949DEB99C53D" modified="2012-11-28" version="1">MVSLPSPGHGPLITAIRSTWNTLDLPKPPSELVEWIRGATPLSTNKEVVVAIATYFIVIFGGRELMRNREPFKLKIPFQIHNLILTTGSGLLLALILEEIVPLYIKHGFYWCICNHGSFTKTLISYYMINYYIKYVELIDTVFLVLKKKPLAFLHVFHHSATAVLCYTQLNGETSVQWVVISLNLLVHVLMYYYYWATAGGRKIWWKKYLTTMQITQFIIDLFIVYFATTNHFFTKWGINLPWVRDCAGAESAATFGCAILTSYLFLFISFYRKTYKGGAKKVNGAKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKB1</accession>
    <name>K1VKB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKB1"/>
    <dbReference type="eggNOG" id="ENOG502SSGG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090072_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKB1"/>
    <dbReference type="OMA" id="RCVYAIT"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852235" evidence="1">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="187" mass="19988" checksum="F1766B1BA591561C" modified="2012-11-28" version="1">MKFTSLLVTATALFGLASARPAKRELEATAADLADPKANFNFSPLESALNTVFSQIEQIPDSVLESGDEATAAWLKENPFQKRDYVDVRVPLNERSDVSVFEERGIDWGKVAKCVATVTSAIATNVIPAAKLLKIKKYIAELGGVKTAIQLLIGATTTAEKLKAGGQALVELSKLFLGVTAIESACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKF1</accession>
    <name>K1VKF1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKF1"/>
    <dbReference type="HOGENOM" id="CLU_1435386_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKF1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="189" mass="20169" checksum="72A6DAE17A0957B7" modified="2012-11-28" version="1">MSTVGETEHTVPAPKLGHAHGTAANPGSQHAHLQLHLACGIDAAAVDAHRALDEGLEGLSRRARVYRRAEERLDVCEALELAPTPLQSRDVDVHIGQVRVALSVLLAGDGSGGAGGEVGRRGRGLRHLERGLGGQRGGRLRVSRRQGGRGRRRVETFDRGRRRRARDGARPALGGTEEIVPRAAEDVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLB9</accession>
    <name>K1VLB9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000168">
        <property type="protein sequence ID" value="EKD04985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLB9"/>
    <dbReference type="STRING" id="1220162.K1VLB9"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="K1VLB9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="518" mass="57071" checksum="94A2FF8EF73ED0B1" modified="2012-11-28" version="1">MSNASNPVAHLRNNAAEWWFKDRGLRQLALGIAVGFSSSVTTGYDGSVMTGLQANPLFMSAIENPSSVILGTIVAAQSMGSLPALFPGAFLSDKYGRRVVLGLGYVLIIVGALVQTFTTGPWKMFGGRFIVGFGGSFAAVAGGPYTTEIAHPRNRAQTTALIQTCFYIGGIVAAWVTFGAVYMEGTNWSWRMCCLFQIIIPAMAICTLPFTPESPRWLVSKDRLEEAHNMLAKYHANGDKEDELVLYELEEIKEAIELERSAAKTTSYMTFFQTKGNLWRFSILVSVGFTSQWIGNGVISYYLVSILKSVGITNAAQQTGYNGGLQVFNWLAAICGSLVSERFGRRKMWLTSAIGMFFSYVVITACSAAYANGHDAAGKAVLAFLFIYFAFYDIGYTPLTLSYPLEILPFSLRSKGVAILMTCLMGSGMFNTYVNPIALEAISWKFYFCFLAVQIYAIVIIYFTFPETKGRMLEEIAVLFDGESARLPAETHLQEEHEIKNETSHVEHNVAYDNEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLV4</accession>
    <name>K1VLV4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLV4"/>
    <dbReference type="HOGENOM" id="CLU_1157098_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLV4"/>
    <dbReference type="OrthoDB" id="10495366at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="26889" checksum="C716898319EE19FD" modified="2012-11-28" version="1">MLRYNNYEPVLTEHFPRTEYRKLDFYAGPKHSETSRILWAARDARREWIRAVDARNWDAIDYQTFRLAVLDRAHELGASAAARRRQEVWQDETDKPIYFAYFLAGRSLARLGREEQVPEPVEVMNFCRAAMDKLAVPVVDMKPARPAWPWNPDELGRYDPRIMHRELLEEEAERFVATFRYDPSIGASVLVEDDTPSLASDSTETSPSRPPGRGCRTPGAPPSSSSSTGRAQSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM44</accession>
    <name>K1VM44_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000402">
        <property type="protein sequence ID" value="EKC97797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM44"/>
    <dbReference type="eggNOG" id="KOG0971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002523_2_0_1"/>
    <dbReference type="InParanoid" id="K1VM44"/>
    <dbReference type="OMA" id="THEREVW"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1386" mass="149265" checksum="6B96A8F3A7BE8478" modified="2012-11-28" version="1">MTTPAPEIPLGARVAVQAGSGYTPLIADPSDTPTGKNNGSVQGEVYFECRANYGVFVRPSQVKVINPNPPKTRPGTLAKAGSGSSASRMSSGTASRSSTPGSKPAASTPTRATPTRTAPRQSVIAPTPPRTGSAASASSTTGAAKRTVAAGGIARPRASISGPSIRPPGAAGAASRRQSTIGAAGSGLAAPTAGDRSRRTSVSDPTRRQSVASTTPSSGAATPASGLAQPSPRNPALGLPSPQPRAQNLSPRPPSARSASSIPSPVHKGSTSLPAPIAHRPPIARQNSSEAMPPPPLPAQVAPVPVHADGGPPSLSHLTAPLPIVQSPAQSPTVEEYDLASPPPEPEPSPPAPRSIPASPNATTSPLLSPRQARKLSVRSSSPDREAAAAVFAQKRELEELRIKVRLLETRRHEDQERINHLEKVSNDADQLHAIRAKLQSKFTRADLKLTTAKFQEQQQALGNAQRQARDLQSENAHMETKVAEFVDQLEMATLDREVAEEKAEAAEAEVSRLNEKVQELELEVAVLKEENAEYERPIEGLEGERTSLAFVQPENHNQRLKEALIRLRDLSQDTEREHKTKITELEKELGAQQDVSAQLELAEAKLANSEAQVEDLKQQLDDALGAEDLLEELTERNLQIAVARATDGAAVDTHVSAVRRLEAADERQRGRLARPIGSDEGEELPSFNAEGYLAHRDELSLGAILLPVPTLVEDLGQVLHDERVAAPGANAGCLGGHIGRHARRRNPLDGLGAGVVPEPRTPAVDPHEQEEGKHTLRRHVHQRGAVELHVAVGDVGPMSAPIAEEAEEVEADHDGSHDTRVGREPRRAQVSEVQVLVCLVALVGAEDDFFFGMCPSCSEPAEAFSVISPRSTCSISFWTLTAVARSLSSFRDALPFFFLPAPEVPKLIGFEDPAPGVSNAEWKSDMVPHALITADLFLGSRHPAILNLIGESTLEEALYEPVQSILNQVRAVKAPAGKLVAIVEDIVANKSSLVTEFTAALGDQVVSVSNAVDIAVQLAQRIGAHVTATRSSKEPLKLADIEKFCATVVAENVGASDLSPWEVIGSFVTRLGTDLGDMLPKFRNAAKAGQTISLDVEAPWLARVQAIKEAASHNAEAERKLSRLQEDLKDTLREVKLREQSLEESGIKIETLERRLEASKRQSDQIAELEEDLQKARKQEKMYEEALEQLQTEQDHLEAENARLRKHGVPEKDGEKGETVKAVEARGMIEQIEALRSAIRFLRNENSLLKSKDLYEDVRMLPPLRSLPDVPAVPELVEDGGSDVESEGPVTPKPRTPKTPKSPLVKNANTRQALDTETKLLYRELAKFSAAPRIVDLSGFDGKGPAWRSRKNSPEAQAWRWTMERVGLEKKVEDLAGRVKALRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM84</accession>
    <name>K1VM84_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase (Alddh)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM84"/>
    <dbReference type="FunCoup" id="K1VM84">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM84"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_1"/>
    <dbReference type="InParanoid" id="K1VM84"/>
    <dbReference type="OMA" id="WSNTFNK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="518" mass="56198" checksum="EEA28CB0D855684E" modified="2012-11-28" version="1">MSNAVFKHTFNHAGYKGDVEVPIGLFINGQWTNSVDKNAKTIPVVNPTTGEKIVDLPEGTEADVDVAIDAARKAYNTTWGLNTPGFERGKLLIKLAELVERDADILASLEALDNGKTFGAARGFDVPESAGCFRYYGGWADKVHGKVIEQSADKVVFTRHEPVGVCGQIIPWNFPLLMFAWKLGPALATGCSIVIKPSELTPLTACYMTKLIKEAGFPDGVVNVVTGYGQTVGNALSSSQKVDKVAFTGSTAVGRKVLEAAAKSNLKKVTLELGGKGANIIFDDCVLDDAVRYAAQGIFFNHGQTCCAGSRIYVQEGIYDEFVKKFEAVSKKITVGDPFDATTFQGPQVSQTQYDRIMNYVECGKQEGANVLTGGVRHGKTGYFIEPTVFTDVKPNMKIVQEEIFGPVVVVAKFKTEEEVIEAANDSIYGLASGIFTQNLARANRVGNALHAGTVWVNCYNELHSQVPFGGFKSSSYHRVHIAKFATQSTAERSALSSEELEDVGEEVEEVGRMVRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN64</accession>
    <name>K1VN64_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_00115</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN64"/>
    <dbReference type="STRING" id="1220162.K1VN64"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_1_1_1"/>
    <dbReference type="InParanoid" id="K1VN64"/>
    <dbReference type="OMA" id="YDGWTRH"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="273"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD05625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="584" mass="65750" checksum="10161764F811012E" modified="2012-11-28" version="1">MGFARQLDLHNLFGWCMYALLAVMTAIGLGNRLLAYAARRGTVTWTGNLLEPWPRLYAWYRRYIGTPAMMGYRNAQPWGILTIPTRLQAILVAIYVTLNVVMGCYGYDTFENNMFWLGRQDLQLARYVADRTGIMSFYNMVLLWLLAGRNDIILWLTGWSYPSLNLFHRWTARVAVVQGLVHSAGYSYLKWGKFWPMMRERYWWSGVYGMLAMGALIPLSILPLRRYAYEAFLLLHIGLSAAFLALMCIHTDMFGYDPFVWLCVGIWLFDRVLRLLRVVVLSYRTLGARNAVGVVTAIEPGLMRLSVDTSVPITPRPGDYYFLYSPHSLTPWENHPFTLASWEKRRDRTTLHFLIAPQAGWTGRLRKRIEAATIKGGESAPLVTAPEARLRVLLEGPYGTRDPIGEYDHILLLAGGSGIAAILPYVYSLGQSSDGKAKKRRISVVWTVRNAAYAADVLSNELAPERTSHISLDLYLTQEEPASARVFLAGLEATLDSGYGAVNPSEVGDRERRDVVFSKGRPPIRELLAAQIEALNGKEGSRLAVLACGPGAMMDDLRADIADAYGCPLLQADASRLEYWLEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN73</accession>
    <name>K1VN73_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN73"/>
    <dbReference type="FunCoup" id="K1VN73">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN73"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002227_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN73"/>
    <dbReference type="OMA" id="QSRHNME"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="256"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="748"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="958" mass="103444" checksum="1BD9056F9B8D5766" modified="2012-11-28" version="1">MITLTPLSSSATSVSPDEPVSYFLELDDARILLDMGQRDYRASAQQTSWEYEEKIRDPTQYLGLYAYARAHWGLKCPVYATQPTVEMGRVVSLAEAESWRAECPVSDEEGEFKGPFVPTTEEIHEAFDHIKAIRYNQPLHLGGELSHLLLTPFPSGHVLGGTLFKIRSPTSGTVLYAVGINHTGERHLDGMVTGQGGLQGYAEDIRRPDLLIVEGGRSNAVNAKRRERETAILDLVTATLAGGRSVLMPCDASPRLLELLVLLDQHWSFKRTAAPGGPAAQWNHPLCLVSRTAQDMVSFARSLLEWMGGVVRESGADDVVAALDRRKGRKRKALVNLGSEYGALDFSHVQFFATPEELLEKYPANRPKLVLAIPPTMSHGPSRTLFASMASVTGNVVLLTGHGEDRTLARELYARWEAHQDEGAHYGHGKIGHATPMEGRLELELDAKEPLSGEELEAYETAEREKREREAAHQAALERNNRMLEADDLESDSDSDSEAGDLAGLHQEGANAFAGDGEDARTMSFDIFVKGQSVLRGTRFRMFPYIAKGRKVDSFGEGLDVGQWIRKGREIEEDGETEEVRAAKRRKAAEEEKAKQAPEPPSKFVSSIVGVDLHASIAYIDMAGEHDGQAIRTIVTDLAPRKLVVVKSTTPASEALKAYFAQTPKITHDAFYPGPYQPIQIGEHVQSYSLQLGDSMGRLLAGRLSRFEGYEIAMVQGKLAYATGSTVPILESADVVLPPLQAEVKVEDEADAATGKEKGTAHGGDTETDAEAKAEAAAEAVGPAGEAVEEKAEAEEDSREAVTDAPATAATAETNADDEAAAEQTAVEAAADIEAAVKTEPIEVEENADEHIIDPAHSLAAREAQAPPSGPLTLPSSLFIGDLRLLALKNRLGTLGIPAQFAGEGVLVCGPGVEPGAKGSIVAVRKLEEGRVVLEGPVSGTYFAVRRELYGSYAQVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNR4</accession>
    <name>K1VNR4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNR4"/>
    <dbReference type="FunCoup" id="K1VNR4">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNR4"/>
    <dbReference type="eggNOG" id="KOG4090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093520_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNR4"/>
    <dbReference type="OMA" id="CDADARN"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15605" checksum="C85C56FC8ADEC347" modified="2012-11-28" version="1">MPRSSRGSVRPSSSHSAPSGSRQAHTASYPQQHAPAPAQHYPAAQPVPAAVPQKQPGLMAQAASTMGGAVAGSVVGHGISNMLFGSSRPAEAAPPPPAEYAQQQQQPMNGASCDIQAKDFTRCLEATNGDMTSCNYYLEALKACQAAAKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP01</accession>
    <name>K1VP01_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000290">
        <property type="protein sequence ID" value="EKD02361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP01"/>
    <dbReference type="STRING" id="1220162.K1VP01"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_20_1_1"/>
    <dbReference type="InParanoid" id="K1VP01"/>
    <dbReference type="OMA" id="WEEGASW"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="229" mass="24534" checksum="7E528416B71D5DC3" modified="2012-11-28" version="1">MSTTPTQDELADFLLSCRFDEGEEVRAFLKTYGAEGLKAAKDERGNTALHMACGNGHLGEVERERAVESRSDDKVAEVDITDVLNALLEVAPAELLQQTNEAGSPPVHWAVMNNHVACVQALVDVPEERGGGLPLLKVSPAPAKLMPQKNAAGRDAFDEAVFAGEGKEEVAGWIEGYVWKAEGGKDDGKESTEQTEEVTLKMGDTSGEGAVTEEVDLSAHTEALKVEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP36</accession>
    <name>K1VP36_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP36"/>
    <dbReference type="HOGENOM" id="CLU_950573_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP36"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852340" evidence="1">
        <location>
            <begin position="33"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="293" mass="32103" checksum="12AD1880274C72BB" modified="2012-11-28" version="1">MRFGPTGRLPPAWDTALRLLVLVLTLFPLAVGRDVHTPGDLRNSQRYIDQTPCSEERWSGKWGNFPDEGVCSFASAPSPADTCPANPLCTTFIPDARSTWIDQYMPFVPLPLETNVTASSANETFCRMRIRAADSNGNSIILRTIWETDDTSVAPRQVTGDFVHLQARGLGAFTLGFPSEESPKYWDAVVIPTGTVASGKSNGWPEGHALPLDRYEEVFGGAGIVMQFPSGVPSHIVVSTRGARIPGTFYCRDGLERRGNATIPGLEHLAYFVLPKGEMPLTRYGPMFSKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP67</accession>
    <name>K1VP67_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosine-purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP67"/>
    <dbReference type="STRING" id="1220162.K1VP67"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413424_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP67"/>
    <dbReference type="OMA" id="MAVCANV"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="73961" checksum="6947785BA25C24D1" modified="2012-11-28" version="1">MSWNDRDPYANHAGYGAHGYDNGAHSFNTAAGSGARGHPIQHPAASQEELYEHPDMNFSQPRVGYDPNDPRSVHSEYYECDPLEGHGPDGPPAGPSYVPYEQPRRLPPTPQQTAQPGMYADSRLSHSVESHGVYHDAPGWDGDSDEKHYAYTPSPRDYVDEKKNSTYSYAPYAVVENYMNPSVASLPLGSKVDIDSGRDLLEPPPPKKKKGFWGRLFSNHVEEKGIERIPESERSSRHLPGLLLLWFSVNLVVSTFPIGLLAQAYFGLSFRMAVCANVVFTAVGAACCAYIATLGPQTGLRTIVLSRYSVGFVGGTLFAILNILTQLGFSCTAVILGGQTLTNVSSQKIPLEASIVIVGFLALLLCFVGYQAVHYWERCAWVVQLAFFCCLWALGGKEGYHLRAQEAVQPTGKAFAAGFLSYGGIVFSSAAGWAPVAADFNCRLPTRTSKTLVFALTWFGLMLPLVFVETLSAALMTVPAYSSAFEEGDAGGVLARAFQPWRAGGKVIMGIMAFSIVANVAPNTYSAALSAQILLPWFQRIPRAFWCVFMFCAYTAAAIGGREHFSEVLSNFLSILGYWVAFFVVVLLEEFLIFRRRIGIDLEAYDNWRELPIGAAGIFACCCGAAGAVVSMAQVWYVGPIAALFSKEGGDLGFEMSAAVTAIIYPPLRWLEIKYTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQG9</accession>
    <name>K1VQG9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQG9"/>
    <dbReference type="STRING" id="1220162.K1VQG9"/>
    <dbReference type="HOGENOM" id="CLU_1284089_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQG9"/>
    <dbReference type="OMA" id="FGVEHKR"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="215" mass="26431" checksum="48D30B6F1435C9AF" modified="2012-11-28" version="1">MGDSRSPSPRRERESDRKDRDRSDRHRRDDRDRDRDRHRDRDRDRERRRSRSRDRDHKDRDRHRDRDRDRRDRDRDRERRETSEERRERKRARREKEDRRERERKEKKERKRAEEDEWVEKGPDDDKPVEVEEQGERAAGGSGRDWMGGDDLFTGFGVEHKRKAEVVSNSERSKADNKEPPKPQHSKYELNTQLLEGKTVDEYATEGEQQSYPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR01</accession>
    <name>K1VR01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR01"/>
    <dbReference type="FunCoup" id="K1VR01">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VR01"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_1_1_1"/>
    <dbReference type="InParanoid" id="K1VR01"/>
    <dbReference type="OMA" id="ADVKFQM"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="484" mass="52410" checksum="AE4A6E199942D11D" modified="2012-11-28" version="1">MPNKSQEGWCSQGWTMRRATKADVVTVRPPLRQTSTRLKSNAYHTVTCTSPHLLKIMTPRAGGGVEVVPKVELCAHVDAVQHRYSTLETMFKFDFDVEAEEPQASGSTVPAPLQRGEVKPSHDISLKDLIATLPADISYTPLTHPVSSYDTPLLKRDLYDARFQLAQDDNAKGEEAQYVDAETDLIPGEYEGGLKSWEGGLDLVEVMHRALGTESALGEWCTGARVLEVGCGTGLPSAYLLRSILASQAEGSKGKGKEGETEKKEERRKTVLHLQDYNLPVLSLVTLPNLILATLPFLPDSARGCAKAQIVGDEEDIPFSPKLPGTLELSPAVLDAFQSALEDAGVELRFTHGDWSGMAAEVAKDSPYNLILTAETIYAEGSVGALLDLLKAAARDGDVKVVKEIKATNDESVEQALDGLALDDWTKKPLREQSVILLAAKVLYFGVGGGLESFLGQVRAAGGWSSRVRDWVKGVGRSVVRIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR74</accession>
    <name>K1VR74_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR74"/>
    <dbReference type="HOGENOM" id="CLU_1176136_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR74"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="25227" checksum="0507C5B5CBFEED85" modified="2012-11-28" version="1">MSVEGRLRSLDLRYERAFKTTSALQARVDALEKASTAAQRLTDAKIRALQKEAALVHAPVDAAARARRARVIVGTLSGRNLWAAETTEVRTAAAGILEALGAPEQAGTALATSALHQLQVSGMHVERLERAVRSCLTDLDVESPSALSDVVIKDAQTLLEWELATLLRRPGAEQGRAVAGTDVLLACTALAPWNADTIDAKKELDDIAALLPPEQQAEAGRRAVHNPAQPPPLYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSB1</accession>
    <name>K1VSB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSB1"/>
    <dbReference type="HOGENOM" id="CLU_781156_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSB1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="355" mass="38846" checksum="8A3C2010B3931C03" modified="2012-11-28" version="1">MPLACTCNTSALSSENGGNDATLPFDVIPPLPFSSFDMSNNTTRNEDSPRRAMDGGSRTDTPRTSQSRRRRETTVASKEAEPSSINPHSDASSRSHDHDHGSSPINRSQNDLASHPDGSSNGSGEPSQSQQAKQRPSAPTSGSELSDDRRRMARNLLRLPGMRQTIGYATRGIAKKKVRRVVARGKAKLKQAFMRAGDDKSSGGARGWRKAKRRTSKAYSSCSSRGDRAAKWVHNQSYRSAGQHNSPRSPDSSGRYRYSFQLSSPSVGDDSREHDRSLSLSFGSPTLDFSAPDSQSTPTKRGRRVRAPSITESLAYEESQEQWRQSEQSLGILVLQDNSPTSAKQPGSLNYRVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSU7</accession>
    <name>K1VSU7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000365">
        <property type="protein sequence ID" value="EKC99717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSU7"/>
    <dbReference type="STRING" id="1220162.K1VSU7"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424003_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSU7"/>
    <dbReference type="OMA" id="KHFERRD"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="11">
        <location>
            <begin position="412"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="646" mass="69617" checksum="1FC967FBC25F263D" modified="2012-11-28" version="1">MAAFSSSPLVESFTINQLHSPSLSPSVSPGPSPTKTEVDFPADVDQSFNSSMTFTVADSPPLPSPDDLNSGKFSKAMLPPPPPFALAPPRRPMAKSGAGLKPTASASDAFSTRPFATTRTFGRELSLNARPLATAGIKGKSPMSSSKHEISPSAPHLESPMPKVRGAEAMDVDTPASKRIGQSPMSVEESPGLGSFFCESPAAPMLAAAKRKALVGSCSSSPSSSPSASRRSRDGKVASTSTLLFGAGNRRSAPYAKRPPLNPLTSVEGPRPGQANSAYPILCGGTKRSGMPSIRRAFSVCDQQQPGLDLSEDESEIEGSPSVQAVNKRHARMASVGIRATNGSPCKPMRLSYVESRDKTAVRPETQPGGFLSRSEELQGKILPCHLTKGDGLARITPQVMKDVIDGKYAAKMKKYYVFDCRFDYEFEAGHIDGAVHVPNLSAIDELLLSADKGISDGPLPTPARSGEGDTTQQTVLIFHCEFSLCRGPEYAKFLRQNDRNMNTQNFPKVHYPEVYILEGGYCDFFKQFPNQCEPRAYVAMDDPHYQDRCEVEYGRFRKWSRSRSYSGQTAKQASSTRVLAEPLSFAPAGRRFGNAIAEENEPDSSPLARGVLQAPAQIFGSTKVRTFKRTGLQRFASCADAQLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT60</accession>
    <name>K1VT60_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol glycan, class C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT60"/>
    <dbReference type="FunCoup" id="K1VT60">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT60"/>
    <dbReference type="eggNOG" id="KOG3059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024002_2_0_1"/>
    <dbReference type="InParanoid" id="K1VT60"/>
    <dbReference type="OMA" id="STSYHAF"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32757" checksum="7599E85B4B3446FF" modified="2012-11-28" version="1">MVECGSSAKEEPGAGQVANHVQPPPASTISSSEPPVPDEPPQWERVLWRRQPFPDNYVPPSFLAELTARLYYGMLEGTLSPTGVGWSCAMIGLVAYALWRIGWETKGKDEHPSGPDSAIRPLLLPPLLLSLLSPVLGTLTSATTSDTIWPLAGMLRRRRKRANSGVSGMVAVAEEQNTLTSALSASVVLASRLPSTAHVFSLVMLAAGLFAGWPTLAKGVRESGKRFSIALTSSMIWLGCSMLPSFGTIVTFLSILAVVNLGGPLMLWYAWRWKRQLGGDWDVAVMNRLISDWCPEKDSVGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT91</accession>
    <name>K1VT91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000356">
        <property type="protein sequence ID" value="EKC99907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT91"/>
    <dbReference type="HOGENOM" id="CLU_829464_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT91"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="34595" checksum="A181A46A2C47F628" modified="2012-11-28" version="1">MTFAPRRPYILLAPAALDLLLLTQPGPTYLRLLCLARASVLIGLTFAARWRKRTLALVVPLASVLACVWETCKSTLYKYPSAPGDGDGDGSGGGKGDWDEWYGPEASATYLAETPSPLPADRGFLFGSLRSAAALRKPSPLGPGRSCSAPAPPSGLRPSVSGATLGEDLAPSASSASLSSASDAGSLGTSPSPVTGPSPERLSPHSQRVVSGSSSGSAALRAKELRNDERSESADLVGPLRVSPRTLYADLPPHTTVDIEAGTYDDGYESSNSESSIIDMPRRRVAPLDAESIGEVAENASASVISVVAGIGGIVRRSASRGLLGTSPGYGTFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTK6</accession>
    <name>K1VTK6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTK6"/>
    <dbReference type="eggNOG" id="ENOG502S8B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_2_1_1"/>
    <dbReference type="InParanoid" id="K1VTK6"/>
    <dbReference type="OMA" id="CWARVKE"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14969" checksum="FDDB6F34D7C27248" modified="2012-11-28" version="1">MPLFLAYCPDRIGPDVLETRLRVRSEHFQGFKQTVQEGHAEFGRGFRPHPDSHLFAPENLALLPEGVEPMAGSVMLLRYDTLEEAWDRVRRDVYWTANVWDHNRLILEQFCEPPPAGTVPGVEDAAGVGTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUL8</accession>
    <name>K1VUL8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VUL8">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUL8"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUL8"/>
    <dbReference type="OMA" id="SGWRPIR"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="6">
        <location>
            <begin position="2043"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="7">
        <location>
            <begin position="3158"/>
            <end position="3263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="931"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1468"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1799"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="978"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1468"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1800"/>
            <end position="1823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3290" mass="368700" checksum="BC783E5081AC1FE9" modified="2012-11-28" version="1">MQVVKDIALRMLNAYVSPYVDNLNPNDLQLSVLSGKADLKHLKLKKSVLERFGLPVEIVAGEIGNLSITIPWSAIKNQPAQIEIDDIYVLARARPQGKVDPEEDERAEQAAKQNKLQQAEMIDSTANRVDENAENHDNKESYFGAIFTRIINNVQIHVKNVHLRYEDDTNTPEHPFAAGVAISEFKMVSTDENWVEAFLQNNVQDVHKQAILEELSVYFDTDAGSVDKGADHQEDTILALKDMLKNKKAEHQYILKPVSGEARLIIHRTMTKTTPKYEGQVFFDEIGVVLDRSQYRDALSVIDVFHFYHRTHQYYKFRPPEEEFEQNPAKARWKFALNAIRSEVHERQRKWSWDYLKERRDKRKQYVDLYIKKLTLPHGQTLQPEDQKALDDLEKELSYEDIRFFRSIARMTARKDAATRKRLEAEEKKNQPKAQTWGQWLWGSSEPSHEEESADQPMTEEQQKEIDDIIDYDAWSAQDPGANAAKDLMKMQIKATLQKGSFTLRTDPHGTPKDVIALVFDSFSAEMTELTESMLAKAALGGFRVYDGTTPNSIYPQVVRVKAIGASQAPFIDQQEPLQDDKDDKDKKEGSTDLAKAKPEATADPFFLAEFEAKPLDGRADNALTVKMRHLEIIYHKQYVEAVYAFFKPPASQLESINALLDAAGETLDGIRSQTRAGLEYALEQHKTLDLHVDMNAPIIIVPMDVTTKKSQVLVLDAGHIAVDSKPADKDAVQDVQNKRGQQYSDDDYKRLENLMYDRMSLTLDSTQLLMGDDIDECMKAIDSPSDGDKDLHIVERINMSFAVQNAIVNTPTLTKFKIAGDLPELQVNFSDRKYHTLMKFIDVAVPHFDSDDEEEDKTLNPEDLEILKSPVATTMKLGRKPVPEYNLDDHHDTRSLKSVSSHDKSKDDEDQFYEVLDGMTEVCCSNERELTARRSRGSSDSDDEEEDKTLNPEDLEILKSPVATTMKLGRKPVPRYNLDDHHDTRSLKSVSSHDKSKDDEDQFYEVLDGMTERKQTQQVTFEFSFAVGKLRTTLYRSTSATTEKPLADAALEGFGLLLKQRKYDMSVDVWLQNVILAMCDGDKEQPPLLSSGAVQDGKDSEHKLVQVNYFQVDKESPDFMSKYEGIDKTVDTQLSTFNITLAPEPILSLYDFIMTTFASDDEGASIEEVGDDGESIKSAAQPQTNDKMRIKVKLTSAQVALENNGERFAILRLPSADVGILMRGGTMRVAARLGNISLEDTSNRTVAAPSFKQLLTIEGQELADFSYETFNPDDETFPGYNSSVHLRAGSLKFTYMQKPTHELYMFLLKFSKLKAYYDAASEAAVQRASEVTRMRYDVVVKTPIIVLPRDGANSPDSLILKLGEITAKNQYLQDPHDTSTIEASLSGINATSEIEYQGKMNTLQLVDDVNINANIRQVGSTEHKDPHHADTEITTDMSDVKMNLTQTQYVLIMGLLQSIPQALSTFNEDEEEGEDDDSTIDSPATESVPPTPVGYDTDTETVLEPELALSPTAKDPSVWTTLDFVFTIKTIGIEVYGAGAHTEDDLAKNSIARFKLIGPHLALKNLSNNAMEAEFALKTLAFHNTRSEANSCFRDLIPELKNEGNQIMVQYAKQADNSALAVVTIDSPTFILAVAPLAALLEFAFAPFKGSEAETPVVEEPEEGQVAEVTDDSTGQLSFRVDIVNSTVIVLADDTNPKTQAIQLSIKEILVSQNNVLALKVDKVGMSFGRMDQPNDRVSFLDDVNVRMSLDTRRRGSKQTTTIDIDVPMPIIFRASFTDMQLILDIVNKATTAAAKAMGTHEDENKEGGAKIKEIKDNDDAKTVATTAPSTLAPPKTGPTARRPSVSRRRASSVTPKTHIMVSKEHLQLHVNGFQFVLVGDVHEMPMVHLSTKEFVCVVNDWSGDLQMGTSLTTEIRYFNLSNSYFEPLLDPWKCDIQMSRTSSTPGATNPLAVKISAAQRLELSITSSFIETGITAMTVLSKEGDRQQKDRSPTAPFRMRNRTGMTIAVWPESDDSSSIPWEKRKLLDNNADVPWFFEDRQALRDNVSAFRHNSFGLELPDSAIKWDPVRGISVDREGEHVLNLRPKIDKVTHQLMCDIELVDNIKIITIRSTLTIDNQTSLPVEMVVVDAQGKANSGIMKIDPGECFPVPFEAVYDKRFRLRPLRGFGFDYAWSAPLFWRQLMTRPIRPISCKHMTPKEPAFYFQAQANFNAKDPTARLYPRMSLRLRAPVELENLLPYDFKFRIHDKATSLSSSNFLVKGGTSPIHTVELSHLLLLSVAPEDTPFKQSDYAIINTDDPELPIENNFTLQDPKGLKLQLKLHYYTYPDSGGAFKVQVYSPYIFLNKTGMPFDLAMKGSMGSQKPVAGSAYFAQDYKKDTPTPFMFSFPNDDRRDRLLLRVDDSRWSQPLSFEPSSADMQIVMPSQNGKREYYVGLSYAEGLGKYKLSKVITIAPRFLFKNMCTAGLLVRQTGEAQPLCSVPPDERRPLLYLAPQPNNQEVVRPQIRIAFDTPNTGLKWSAPFYINDIGKTHVRLSRTTSRGATKEYLMRIETHLEGSCIFLYVSRETDPWPIIIKNETNVPFKFKQTPEDGVEPNALPERPIPGQTTVEYTWDWPTATGKRLLLSTGGRVLSRPIDVMAIGEQPPIKIPRPNGQSPITITIDVRADGSSQSVVIAPYNEERNVYKLAKRGPLNHSQSSLSVNSSSDTISAVGAEAEHTNDPPNLKLNVSLEGIGISVVTKRPDELMYLTLRGLEIGYTDYPTYYDAFVNCKWIQIDNQLFGGLFPIILYPTVVPKDGKDLESHPTLQTAFAVLKDQSHGVIFVKYASVLLQAMTIELDEDFVMALIDFTKFKDATWRDPVKDVLIEYPSKEIQEPDISHQQSDIFFESLQLQPVSLEVSFMRTDRVNVDEKVSTRNPFYYALNALTMTLGNVNAAPINFRALFLDNVRLSAHDLQERIILHYQEQAVAQIYRVLGSADFLGNPVGLFNNISSGFADFFYEPWQGFVMHGNRDIGLGIARGATSLAMKTVFGITDSMSKFTSSIGKGLSAATLDSEYQTKRRMTQKRNKPKHALYGVAAGASAFADSVTSAFEGVASMPMEGAERGGAAGFAKGVGKGFVGLFTKPVVGMMDFISASTEGIRNTTTVFDSNDIDRVRLPRFIASDGVLRPYSSREALGQSWLKDLDAGAYFNETYVAHLDIPGDDAVAILSNARLLYVQLRKMRVIWQVPFDELQSLSLEQSGIALVLRGGTPGPFLPIAEQTGREWFFRKIAKVVENYNKSHQAGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUM5</accession>
    <name>K1VUM5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUM5"/>
    <dbReference type="HOGENOM" id="CLU_1455372_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUM5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="186" mass="19731" checksum="CBD785E12CAE3AF3" modified="2012-11-28" version="1">MSTSTASSPAPSTTSSVGPLSFRASVEDVALVWDSLAQLHAHDVTFDIVTSTLHIDGLAEEDLDPVIDSIHALIGHAEPVCEPASPPQRAWLRQPGTAHKEPRLPTMPFAVAISMAASSNSVGCMHRSACDSPYEQPPWQCWPLESLTSAMTNEHDHPCIAETSPPTAPVDLVRHACLGARPLSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV00</accession>
    <name>K1VV00_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV00"/>
    <dbReference type="HOGENOM" id="CLU_2147628_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV00"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="112" mass="12151" checksum="F1A3447F04FB9120" modified="2012-11-28" version="1">MPHDLHDLSMDLDACEPTELSFSTDDTPLDVPTSIHDLSERYPFDVEGIPLPPSPDLSELSDLSEVSASLDDIDVDIAFEPDETSLNHAFFKALLFLAAGAVSHSMDNSTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV38</accession>
    <name>K1VV38_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV38"/>
    <dbReference type="HOGENOM" id="CLU_1644911_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV38"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854379" evidence="2">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="161" mass="17757" checksum="8235916AF7841ABF" modified="2012-11-28" version="1">MKLQLSILALLSTLAFAAPVPEPLDCSKTPEVAACSGPLRWDKREPEPLDCSKTPEVAACSGPLRWDKREPEPLDCSKTPEIPACSGPLRWDKREPLDCSKTPEIPACSGPLRWDKREPLDCSKTPEIPACSGPLRWDKREPLDCSKTPEVPACSGPLRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVD4</accession>
    <name>K1VVD4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVD4"/>
    <dbReference type="HOGENOM" id="CLU_2428628_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVD4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="91" mass="9933" checksum="C7E9D2628F3069CB" modified="2012-11-28" version="1">MSTIPKSLKHLDVSFNRISGSLPNIDIDLTGLFVQGNYLTDLGRLPESLQNANFSLNPLTNTGELCSRKLVTCELKKTKLNATTCGTCLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVS7</accession>
    <name>K1VVS7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Importin-alpha export receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVS7"/>
    <dbReference type="STRING" id="1220162.K1VVS7"/>
    <dbReference type="eggNOG" id="KOG1992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009614_1_1_1"/>
    <dbReference type="InParanoid" id="K1VVS7"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="351" mass="38835" checksum="215F18FA498857FB" modified="2012-11-28" version="1">MQANPETLSAVSKCLANTVSPDAAARRAAEEQLRQGEAQAGFLPLILQLVRSEEADMLVRQAAGLYFKNTVKRLWDDEEEVQIPEADKAAVKSELVPLMIALGTPKTQRLQAQIGEGLSTIASSDFPEKWEGLIDELVNSLTPDNFVVNNGVLATAHSIFKRWRSQFRSDRLFSEINYVLDRFCKPHFELFKHVDSLLDTPAGQPLPPNASLPLLAQALLLLIQIFHDLSSQDLPPFIEDNMGAFMGDGDQQGWLHKYLSWERPELKGDDDDEAPGPLQKIRASICEIAELYAQKYSDVFPQLGNFVSAVWQMLTTIGPQTRDDVVSLGPCLLAALTSACFAGSSLPVRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWI8</accession>
    <name>K1VWI8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWI8"/>
    <dbReference type="STRING" id="1220162.K1VWI8"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040839_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWI8"/>
    <dbReference type="OMA" id="CNVTLGT"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852515" evidence="3">
        <location>
            <begin position="17"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="94"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="438" mass="47534" checksum="F5BBCED2DA2CF0A3" modified="2012-11-28" version="1">MYVLIVLTILTTLSVAASETSGGVTLPLRRHARPRPQTLSSHHALLEAHIRTSHGLERRHLESELESYLSRSSSTLAKRNGTTSTDAKNWGYVYTVPVSLGTRPQLHEVIFDTGSDALWVWGAPPFCNTSACTAVPGYDASKSSTTAKAEYERELSVAYSDASEAEGEFVRDVVGIGSISFPYDFGLAKTANMQYWVNTTTVGIMGAQRVAVKNGDKPWEVVTDEKAEVWWVEGWKKGHLAENLIGVEMSNPDHDGLEVQRNHSSPGGKLTIGGVDKAAFEGELHWVPVVPWSPQQWKVKLDGVAGPNGTVHKLENCTTLIDTGNTNVILPQVVLDPAILSIPGAKHVANGKKYGIPCNTTESISLVYGGKPFRLEPSKFLGKKLTGVGVEGLCLAKIDPNPEVQTAGVVGEWFFHNVYHAYRIEPAAVGFAPYKPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXT4</accession>
    <name>K1VXT4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXT4"/>
    <dbReference type="FunCoup" id="K1VXT4">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXT4"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="InParanoid" id="K1VXT4"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="554" mass="59761" checksum="DEC0520DE9A7678B" modified="2012-11-28" version="1">MSLKVPKASGPDLFKPGYKHLSGLEESVLRNIAAAGELSEIVRTSFGPNGRNKLIINHLGRLFVTNDAATIIREIEVAHPAAKLLVMAAQAQEAEMGDATNLVLIFAGELLKRAEHLLTMGLHPSEVIQGYEMALEKGREELETELVTSTMPNQPLPTVDQLAAAIAPSLASKQPGSERFLSHLVAEAALTVMPKNPRDFNVDSVRVVKIMGGSLDKSRVVRGMVFGREPEGTVKSAKKAKVAVYTCGLDISQTETKGTVLLKNANDLLDFTRGEERQLEGYISEIADSDVKLVIAGSGVGDLALHYFNRFGIAVVKCLSKFDLRRLCRVFGATPLARLGAPTPEEAGFIDVFETIEIGGDRVTVFRQEQGEKTRTATIVLRGATSNHLDDLERSIDDGVNNVRILLRDGRLVPGAGASEIELARRVQDYGAKTPGLAQHAIRRWGESMEVVPRTLAENAGLAAEDVVAALYGAHSNDEVDAGVDIDAENPPAIRRVTDTNDPRGTVLDAYAAKDWAIKLATEAAISVLRVDSIIVAKQAGIAPPKQQGHWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXV6</accession>
    <name>K1VXV6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXV6"/>
    <dbReference type="STRING" id="1220162.K1VXV6"/>
    <dbReference type="eggNOG" id="KOG4275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1200538_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXV6"/>
    <dbReference type="OMA" id="HLAMCAP"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="25316" checksum="28317E62B7BE9A12" modified="2012-11-28" version="1">MSLVPLPRSYLSSLSIGTLKAILYENHVHVDFSQVLEKSELVARVAELVEDERKRLERQRWEEEREEREARGEMSPGPSGLDGDLIDLMGDAEPIDIPTAGDGVRSDNGSGSEPRGARSPRSPPTGPQAEDRGLCVVCQDEEATLAVVDCGHLAMCAPDSRLLRPRHGDDEGLSHVSDEDRDAATAYQDLPGVSAVGQSGTHHGRQGPVLPRVWRVEHRGWSSEAWKRCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYA7</accession>
    <name>K1VYA7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRT1</name>
        <name evidence="10" type="ORF">A1Q2_04044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYA7"/>
    <dbReference type="FunCoup" id="K1VYA7">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYA7"/>
    <dbReference type="eggNOG" id="KOG2314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011152_4_0_1"/>
    <dbReference type="InParanoid" id="K1VYA7"/>
    <dbReference type="OMA" id="LWGGPQF"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="756" mass="86555" checksum="A4CF2FFD9A6580B0" modified="2012-11-28" version="1">MVDADLAGFSEEERRDIQAELDEGYAEIEQQFAPDTQQGFENVLVVDNLPTVDEAKRARLLDRLRQVIAKAGAPIEEDRINMPWENGSNKGFVFLTYPTPQEAEHALRALDGVNFGSKNQLHVNRFGDIEKFANMPIGEGELPTGWREKPYVEKDHLRSWLGDAAGRDQYLTFRDQDVNLWWNSRNGTADPVKDSDGKNIKNPKWAELYLQWSPNGTYLASLHRVGVALWSGPKLDGPIGVNVLRFTHPGVRMVQFSPCENYLVTWSDEPLVVENHPAPAVRETFGPEDEGAQFVIWDVKSARPLRSFRADAPPSDPDAPRPQQAWPVFRFSPDDQYVARCQIGNAIQVYELPGMGLLDKKSIKIEGVQDFDWCPMSEKDWAARKEGKGKECMLVYWTPEAQNQPARVNLMAIPSRKILRSKNLFNVTDCKFYWQNQGDYLCVKVDRHARKAKSKKATFCNLELFRLREKDYPVEVIEHKDYVPSFAWEPNGNRFAIVSTNDPNFGQNVPGAVVKYTVSFYQPDPKKGDFTPIKHLEGKVANTLMWSPRGRHIVLATMGSPTKFDIEFWDLDFTLDDSAAKRESAEPGANVQLLATGEHYGITDMAWDPSGRYLASSASSWRSTPEPGYNLWSFSGQLLNHSAQDKFKQFLWRPRPKTLLSREQQKKIRRELKEYSRQFDEDDAAEENRGSAEKLAQRQREIAEWDAWRQRNNARLAAARKQLGKELKKAQPKEEDEEKIEEWTEELLGEEEEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYF5</accession>
    <name>K1VYF5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYF5"/>
    <dbReference type="FunCoup" id="K1VYF5">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYF5"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_8_1"/>
    <dbReference type="InParanoid" id="K1VYF5"/>
    <dbReference type="OMA" id="ECQQSRS"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="379" mass="42552" checksum="65CA102D2093C593" modified="2012-11-28" version="1">MFRVLASSTIGSLRATHTLRLSHSLRLYASTSPKWLTDEEAANAKLLEAVKSRVDQFQTAQDSILEIEPHLSDPDETIREMFAAEKEELLASLDEALEPLPELLLPTPEVAELPVMISINAGVGGSESALFAMEMVRAYTRYANQRGWKVETISETKGPDDIGVRETTVKIEPAPYSEENNEVYGSFQWEKGVHRVQRVPATESQGRVHTSTITVIVNPIYPDKPEAPLVDPKDVRTDVMRAGGAGGQHVNKTESAIRLTHLPTGITVSMQDSRSQHQNRAWAWEILRARLSERKHQEEVEARRAARQSQVKSANRSDKVRTYNFPQDRVTDHRIGQSFNGIRDIVEGERLEIVIAALREDFNSRRLESILQGEGDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYN7</accession>
    <name>K1VYN7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYN7"/>
    <dbReference type="STRING" id="1220162.K1VYN7"/>
    <dbReference type="eggNOG" id="KOG2148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002075_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYN7"/>
    <dbReference type="OMA" id="SFMRVFP"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1238" mass="136399" checksum="67043F3FBFE5485E" modified="2012-11-28" version="1">MSSRDEQQAMTRSLFSRRDEDGNLEENLLSYIKVFEEDGGHGKTRYLMLALNKHGRPLLHKGKKNSNGTFSKGKTWQLDDMRMLEQIGPIEFALAMTVRTYRWRTERPDALQQFLGSLVTSFQDFTGHLPELVNFSVPASQSYQGASSAHGHSPAPEGPPPAPSTRLRGAPAMSSQASSSSSATAGGRRPSVQTLDDRGRRTDDHGRRPSAQTLDDHGRRPSVQTLDKRGRRPSAQTMDDSRSMDSHHHHQPSGVGIGEVFDQSAFKQGNGTSAAYDAMGLSRPPTQRQNSNDTPPSSVVGYSGNGINPGAMAALGASSGRRPSAGSATSPLAPAQEDIDDPYGGMEEESLATPQNGSFSHDDQPMIPPPPSSAPAVPALPTVTESPAQHERTPSTPAMAKSPSGSSQATSSVPDALAPPTLRERRAPSPMYDDEQEPPEQMNRRVSFHPAPPSFTTAYSRDVLLTSRSGLSGADVVIEGEDDESGDAIMANVEEMIEGFDWTASTSATAGESGRKGPDAIEQRLLDELAALESANIHAFLESDDRVEQVLQHIDDTLAELEDIDLHLTGYRMQLNAVQDDIDYIEGQNRGLQVQISNQHALLKEVQQLLAITDVPKEDLQALSQASPSTQRGVQELEQAATALYKALQAARDNEATGAHIQEYEKIAVQFATRVLEYLDITFKHKSSETLAKYKKTSQLKLEPHNELCESLMLYEGLVLWVKDMDDERYKKLCLLHEDEMKKLLVMLVQNLSKSIEGVVDVSFAKASQGAQQPAGIGGALREGVARSKTLRQKAPGADHAALRDRKADGSTRKVAELYSRGMGEIVSQIVTEDSFINAFLHLADNETTFADYMDLDTYFRRQAGRHSAAKLGKNPALAQIARTVMDLMFGFVDGEWKNWIEAAIGLSGGTLGSQKNTVAIVGVIAETETLLQGAEQEGGNLFLVQLFEKQLGRQRQIFDSFIKEQIRTIDGAKNTIKKRRGVFYFVRHFPVFVERIESQLGTAEGLDIRKRVNDAYEQVVASVLGSLQYVSKLVGSEISSGEGKDQLYFHVVMIENLNVFVDETQKLKIPALAVFVQRARGLYDENMKAYIKMMLRRGFARLMDFFDGVERLSRTTPANEISVHSNYNRSALKKVIKEQTAKDMRKAVEAMARRVDKHFSDDDSAPGVPGANHHRDHQNDKATQDLINYVWREITSTLVGEISRANEYLSKSYSDSGLSFDFNGRDVEQACQRAKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYR8</accession>
    <name>K1VYR8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000213">
        <property type="protein sequence ID" value="EKD04657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYR8"/>
    <dbReference type="HOGENOM" id="CLU_1628227_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYR8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="163" mass="18043" checksum="6A85DB9D0C3705AF" modified="2012-11-28" version="1">MRVSSLVRGCAPVKAECPESWRTNIVIGIVVVAAVEVDPFTKGWVPVVSKDDHNEVLWVTDARSQGEASCKRSVLEDVVDDMKVGYVVMMPWHCRNDEGMLRGGMLYIFVRRLENTIAGLDLVQWSGEGLPSTTGFEDDNLGFLYWGAQRLTGLDLPGLSDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W141</accession>
    <name>K1W141_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_02928</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W141"/>
    <dbReference type="FunCoup" id="K1W141">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W141"/>
    <dbReference type="eggNOG" id="KOG2831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_2_1"/>
    <dbReference type="InParanoid" id="K1W141"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="15">
        <location>
            <begin position="102"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="16">
        <location>
            <begin position="272"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD02698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="349" mass="36975" checksum="C80D89ECE3425354" modified="2012-11-28" version="1">MSGAQTPVNDAASTISVTPAAPQQASSGNDRASKSSFGYESAMSLLVDSLKDRLLFAIPKKGRLYEKTIELLKGADIKYNRAHRLDVALVQNHPIALVFLPAADIPRFVALGSVSLGITGQDVIAESTHANMIQEILPLGFGKCKLQVQVPVTGPIQSIEQLRGGRVATSFEVLARELFNEVDAKAGGDKKTSIEYVGGSVEAACALGMADGIVDLVESGDTMRAAGLHAIHTLMSSEAVLIGPKQKHASLTPELEPLVGLIKSRIAGVLAAKKYVYMSYNVSRQNLPAAVKLTPGRRAPTVTPLDEDGWVAVSSMVERSQMAQVMDALEKTGAADILVFALDNCRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1G9</accession>
    <name>K1W1G9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02787</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1G9"/>
    <dbReference type="STRING" id="1220162.K1W1G9"/>
    <dbReference type="eggNOG" id="ENOG502S794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1200536_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1G9"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="135"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="25461" checksum="754E97DCFE0029D9" modified="2012-11-28" version="1">MQAPAPGPAFGEVPSPAPLEAVSKTSSTAGSKRGRADDDEPTRPGPTPLPHHRGSSNSRQYRVVPRAPAWDPNLPPRVITNAEIEAAKSALQFIDAQAVAEEGQDKEMSAFQDMLNEYLKLEGSSGIKNVNDDDDEYVYDLYYRDISGATAEGANIGALLGYEDLSPPSTPPDSEPEDEADEDSNDEDFYRNDYPEDEDADEDMVGFDDAYSDGEWSKEDSEEERDVWDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5I7</accession>
    <name>K1W5I7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_01529</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5I7"/>
    <dbReference type="FunCoup" id="K1W5I7">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W5I7"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_6_1_1"/>
    <dbReference type="InParanoid" id="K1W5I7"/>
    <dbReference type="OMA" id="NIYHRWV"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD04183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="691" mass="74234" checksum="31A3E09A1C4126D8" modified="2012-11-28" version="1">MEFLVARQEAEGAGGAGGRSAGQKVTDAVTSAVKSAAAAATEAATGKSGKGESSGKGESSAKGASSGKSSGGGLVNGMDKATRKALLKAKIYRANYIMWWVTTGVIGAIAILYLLRMWRAHQIRKRVAAKRAAGAAATNGKRGSALGAAHAGWANLAYVRTWPLWIYGSTSAAEWFWTAAYTGICLGVGFWGCISPIDGKLDYANPIGVVAFAQMPLIVGLASRNNVISYMTGISYEKLNYLHRASGRVCVLTTWLHTLGWFHKGLGKHGPGTKIFLSGMLGSVAVLVLWLTSFQIVRKTVYELFLFFHITMGIMFIVASYYHWPRMAEWTWIALLLWGIDRFVAFARLFFHNKTWLMWSSARHAEHSGSVVELIDDDVVRVTVNRPLFRWSPGQHAFLTMPGVAMLRYEQHPFTIVNIPDESGDVVFIFRALQGFTRRLVNRLDSTTTTDINAYIEGPYGGEGFGHGIGHGPLQQHDAVILIAGGTGISASCSQFLNTIKCSREGTTAVASCRLVWNVRSPRALSWIAPLLNAEFAKGAGSTKFHIDVYLTRSAVSDDPTVEGQKDPAQFASLEDSPEGSPAGSTENVNEKTSSTGSMGGADEKWIAAAGISPTVAQIVQFHKGRSPLETIIRDDTLNATGEGDGVGVAVCGPTSLSMAARDAVVAVNRPSAIAAGHQQEIHFHSEVFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6J8</accession>
    <name>K1W6J8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6J8"/>
    <dbReference type="STRING" id="1220162.K1W6J8"/>
    <dbReference type="eggNOG" id="ENOG502SHNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053163_1_0_1"/>
    <dbReference type="InParanoid" id="K1W6J8"/>
    <dbReference type="OMA" id="CDNWEGC"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="31001" checksum="F5EE5ED256EF380F" modified="2012-11-28" version="1">MDLPSSLPTTAAGYTPCLPHPKLSFLKGDLTDLSFVDTLYANKFEFDGVIHLGAIPNPRDDLDDRKLHMINTCSSYNILRTSTDHGIKRLVQASSVNAHGLSYSPPGHAHFDRFPITEQVEKRPEDAYAISKAECELQATAICRWAPGTRVASLRFHMVRESYDHAWPDCTARDIFSWVSYESCARACLLALEKGEWRGHEVFNIVAPETCWEGSVEVQRKKGEGAGERAGTVELLTKYWPDGELDMAYFEKNPRAAAWTSAKAERMLGWKHDPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7J8</accession>
    <name>K1W7J8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7J8"/>
    <dbReference type="STRING" id="1220162.K1W7J8"/>
    <dbReference type="eggNOG" id="ENOG502S9PG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1138692_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7J8"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF15">
        <property type="entry name" value="VELVET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="38"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="244" mass="27214" checksum="14CDC033A51F295F" modified="2012-11-28" version="1">MDADDSESAQPTQYGEEPTSSPRAQSSPPTPVPPPTIQPTERYGWRVTPIQEPNTGAAFMFQELARIQLMPLLVVQIDCWDPETQQFIVPPPEELATLVVMVSVQTIDGEDASLVRLREDDTVAHSTLYGGRVQMTHLLPSVNDPNLTGCYAFFPDLSIRVPGEFRLRFWLQRVSMDPDHQQPSVGSYLDVYHTGGFRVVPLHQFVAPPRIKLTSAATTELTTHFASLGIDLHLQDANWDLDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7K2</accession>
    <name>K1W7K2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7K2"/>
    <dbReference type="HOGENOM" id="CLU_336222_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7K2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="842" mass="95631" checksum="874F4BEAC426307D" modified="2012-11-28" version="1">MPASHAEAQNHIISVVEGIRNGRQIDLANGRWDNSPIELIVYGFKESQNIVQTLRSALCDVAQPHQGIEPFAFHTDQLLVRELEHVAGQQTSARICWDPGMWTSGLDLVKEMGTVKSHLQERGYEVFWASTAGQDHRSTVRFVPVPVNNRHYQSSRPDYAPGRTSWIQTACSEELYEDIAASRVIYGNNREPDAAVEIDFRHPSSVDNLVALFDSSERRQWFETTFGITQFRRIRSQILIAHPAMIASPDRGHYGREGLLAALDEWVAEYNAVFQAEERLLPWEDGSRGKFVFETNFVVIPSSVGLAQFIAEQKPRHGYPFELLYDLNGRCLVPASQAAAKLELERLQEGRYIDRRLKRIERQLRNIKQHTDLYWNVGERIQISSQGWRNPEFTSAVLEDLKARISRGHGLSHLYSFGNSSEPEESSEEEQLGELDDNRNERKQLDVDLYYGEQSKKTILIPDDPTPFGASATRSLAQCAPPSESSADSPVQLIIADLPFDVREPKLAVISEVLQQLQHNYEFQPSIDWRRLILSEEPGPGYISTRIRLSWSEDKLMDDANLVDEMNAVRQALQDSGYRVFWANAPIDLRNVSDVEMSDDSGSAQPALECRSFKWLYDQCVRAGVEPVDASGGRSCPRYHKYRLTFRTHSDPDTLEAYLRSEKLLYRGEPVLFHRPQIAVSYPTNIGSPGRGNMSTSYLLAEIEGWVTAYNSKRSTRECLLHMEGGKSWEMVQGVFIVKPSSMHLAEFLARQIPRCGPKYELLYRLNSRIHKAADASPSFKRQLEKISKDLSHVQNTVCRVIPNFWAGGEASDNSWDLEFGHHHGTEAESSWSSEAEHLLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7V1</accession>
    <name>K1W7V1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7V1"/>
    <dbReference type="STRING" id="1220162.K1W7V1"/>
    <dbReference type="HOGENOM" id="CLU_515046_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7V1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="529" mass="56981" checksum="57E08E8F101791CD" modified="2012-11-28" version="1">MPGAKPSVTFSSVEEPRHKALIAADIASVLCGLGLSLALDAIGLVVGLLVAVASMVLGIALLISANSIGALSVGQVFYSIGYTANALVLSVLLRDTCTLRARGVAIAFLNTPLLFSTYVSPFIYTASTSSHLSFETILGIMCGIIGLLGAAALLFLSWLVLDGLALKAASESLIDFLAYQLKRLHVKIVCCFGVAACTVFLLAYSELIAWYTTLPAFFSLSVYLCAMVICQQLEPCLKRWLVRTTHWLPTKLAELVHQWNNRPAPSPDKKHSTVYSAYVVSFAWNAGAWNQNLPTHSKLAYDLNDAYYLTTLDSTITLFFSFIIGLYIYYKGRFKSLMPFAVALHFLGAVLAFIAPSASHSIPLLLAGDTLMSIAHMTYSTAAEVSSLFVNDAHDTTIMLGLIDSWEKLGSVVGGTFSDLMWTTFAIPKVSPFYLSADVFLEPSETPSRLDMYLEMSKDHPLRVEASLLSDKVQRTLLLIGSAAIALAAITIVAVAEGNVIETNLQPEADELSSNSADVRSSSAALPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8C7</accession>
    <name>K1W8C7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Succinate:fumarate antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8C7"/>
    <dbReference type="STRING" id="1220162.K1W8C7"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="InParanoid" id="K1W8C7"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="72"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="176"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC97908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="281" mass="30614" checksum="49B1485544728760" modified="2012-11-28" version="1">MQLAKSNKASGAKPLGFLATGKQIVARETPLGLYKGLGAVVTGIVPKMAIRFASFEVYKSWLADETGKLTGSSIFIAGLGAGATEAVLVVNPMEVVKIRLQAQHHSLADPTDVPRYRNAAHALYTIVREEGFSTLYRGVALTALRQATNQGVNFTAYQYFKKWATQFQPQYKDSGLPSYQTLVLGLVSGAMGPFSNAPIDTIKTRIQKASKVPGETAFGRFMKVAGDMFKNEGVSAFYKGITPRVMRVAPGQAIVFTVYERVKRMLDALKADETKKDDYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8S3</accession>
    <name>K1W8S3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8S3"/>
    <dbReference type="HOGENOM" id="CLU_1628219_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8S3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="163" mass="17721" checksum="C605387230F07C84" modified="2012-11-28" version="1">MAAELQALDGRIDEGRRPARAAVAFTVGDEEHEMGDLRQAERLVAPGVVELDVTSGRKVHEELAEAWGAGNVLGDRDVLSALHRLLLPRHAAARVEERQLAPGTSEGEAAVLLAHDCKFGSISQENPVRQATHVLADLPDRNQGVVVELSEDLLDDVWEAIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W941</accession>
    <name>K1W941_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000119">
        <property type="protein sequence ID" value="EKD05343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W941"/>
    <dbReference type="STRING" id="1220162.K1W941"/>
    <dbReference type="eggNOG" id="ENOG502SDCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783438_0_0_1"/>
    <dbReference type="InParanoid" id="K1W941"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="354" mass="38188" checksum="AF0F92821D5BFBC7" modified="2012-11-28" version="1">MVPEVLPNPPPLEPTEEEYAEPSSNRSSPVRPTRPLDQTSPHFRPVFASAFPPASCPTSPIPRNLPISPEKIGRRPSKTWMPAPPNHVPTPGSPNMKTVALPTLTPTMSPNESHRELHPGFRLEENLHQMSLLHSHEAAHAGDPVSPLSGPPLQSPPEITSALHPGSPLTSPPVTSSASPGGSEDDIEKAKVNRKIADLEISNSSLLSINKTLEKTKALQRAEIVKLRRRLREQELPPLRDPEGGSGLGLTHQDSDEDDDLGNLTDPELESRWDRLIDMVTVMRRAGEEAIMAKKSGRAVLPWLDLDGEKTESVAGSTAETIVTEQTESVTEVGTDAGTDNGTETGTEAGTDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9L1</accession>
    <name>K1W9L1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9L1"/>
    <dbReference type="STRING" id="1220162.K1W9L1"/>
    <dbReference type="eggNOG" id="ENOG502QT5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303075_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9L1"/>
    <dbReference type="OMA" id="WERICTH"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="702"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="983" mass="107582" checksum="AB63846C9437A1EA" modified="2012-11-28" version="1">MSIIAPSAQTAFIAFLLAYDSVTKSYGSIKPDPICRRIAELWEAAHSEDPPQLLRPTGTGGWRTWEGGNPQGNRRLAGFYQIRITLLETQLQPNSGRAWSHAWLLPVILPRDPTSFPPKSRRLSVGGTHPTARPRQVVTVTQPPPVHATVHRDRIRLLAMSDMPPNIPLRPPRHHSVARGSSTASVASVASVASSSSSASSPKRAPPIPPKTSRVIDQYHADRNPAQWASSRSSLIPAPQRAILAQPPQAPRSRAQPRTQAFSTHQAQQRQENQLGLITRRPPGRVAAMVTSAQQRSNTATSTGSTQSFTSLARSVLSAAGAAGSAVANTVVGSEKTRGPGKETIFLVPGWGVKRPTKDGNELGLCVFERDPGNVSRTQRAMMSLVRRFAALPAIPTLPPKGKGALMDDKLTDSPTSDPADDKDLPEVEDMIDLDSPPGTPKKGRPPPPPKPKPEALRGNTVSRKGALNSTDTTPTATPPPSTRRRSPSPPSRIPSTDQVFLDNEQLRLAHEYLDTRLRPFWSTALPNRRVALSLYTVKLIDSKPVPEPGPELFDKEPLMRTTFTTNSQGVFIHHFAIPWERICTHPESIGLAFSEDPQNSDPHKDWGLVFRAQLLSEEGPDGLQRATTSDSMNSTDSSRSSRYKSRLARAEGAATSFFSRSEIPNRNDGDGDQEMGLMGLGEASAEAINVANIQRPGGVRIISDLHSDILSGPREVFRNVFCRRLEDILVHGMNTLYQDLTRIGLSGVHFVSNSPVSIYPLVSQFLQLHKFPSFYSLKLKMYSSRSIVTSLFEGAGDRKRPPIEDIMNEFGDSKFLMFGDSGEQDLELYVSLARERPKQVLAIFIRDVTSSRAEEARKVAEKAGLMSHSELAENESAKQRQEEHGVYASGNTYDRSPSPTSSGASTPTSTISRQPTDQDMKQTIADLQSLSAEEQKVLKRAAQWETRVNQALDAVPPGVKLIFFKEPEEIESVAQALVEANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC05</accession>
    <name>K1WC05_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC05"/>
    <dbReference type="STRING" id="1220162.K1WC05"/>
    <dbReference type="eggNOG" id="ENOG502SB3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387417_0_0_1"/>
    <dbReference type="InParanoid" id="K1WC05"/>
    <dbReference type="OMA" id="YLATMEY"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="713" mass="77837" checksum="672681E7639BD3CC" modified="2012-11-28" version="1">MDLVALIVEDAGDQAGKGKARAGPVHTIVELWRMSGSKVWEVNITGRVLGLAWSRDGELSSLEPWPDHELSGMNKSTVQHLSVHTGKVTKAVLVPPKVIKQVSRADWASAADRSARPEWWPLEWVDGGTDWEKPLVSCFIVATCHVRRLLRAEADDSINPFAPPPPTAKDLGPHKKVETFPSLLPSNPRAPPDVLTLLPPARETGREGSRLLTGTFRLPEGTPSPTPPSVLGLSERSDRLASLINILFRGIESIEAALRDGDKQTMIWREELETCGQQQGRSVDGFVMELTPDRFEMGDNIVPALERIILILDELLSWAGEEAESDLSIDSEATQRAIDIAKAFALLSEHLRQEAELEEAASAEWCKWLRFEMTRITASADDALPIPTHDVKLVWSFMKNGFLHPRFAVNFPRDPDAAEDVLPSSIPPKAPAMSSALDAVLRQTLSRLGATPAPEGLSSPPPFGDQSLDSAAASPLPVSPGLVPSSPDTAGGDAELTEDKPIERYPEVEPLTWANTLLVLCSDIVTAVKPRHPQEDAANDELLRALPQETLLSERTIDGVRWLVFMQSGSTASDAEGALRGVRLCVPEGDIVQAGFFDDEELAVVFQLRGERYLATTTVEALSEQLVDLPTVKENLGSLDLNPQELAVARCRVIGPARSSTDSWLLALNGRKGRRTCCVLTKGGTEVEVLDMDMNEDDEEEEAEEVEADVDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCR1</accession>
    <name>K1WCR1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCR1"/>
    <dbReference type="STRING" id="1220162.K1WCR1"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="K1WCR1"/>
    <dbReference type="OMA" id="LNHHDLW"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="359" mass="38262" checksum="51B1C4D422CEFD47" modified="2012-11-28" version="1">MPRELLVKKIDGKPGQVYYPLYIRDTPIPKPGPNQVLVRLKAAALNHRDLFIRQHLYPGIGFDHALLADGVGVVTEVGSGAPQDLKGRNVLVMPFRNWEDDEQGPGSDFHVAGGTAASDSGTGRDYMVIDASDVVPAPPHLSAVEAAALPLAGLTGWRAFVTKSGAAQKGKNVLITGIGGGVALQVLQFAVAMGVNAYVTSGSEEKLQKAKELGAKGGVNYKTQGWEKELKKQLPKDRPYLDAIVDGAGGDVVSKGVKLLRTGGVIAQYGMTVGPKMDWTMNAVLANLELKGSTMGSKKEFNDMVKFVAEHKIRPVISTTGSLDDMNSVEELFTIMKEGRNFGKLVIKIDDGAASPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFI1</accession>
    <name>K1WFI1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFI1"/>
    <dbReference type="STRING" id="1220162.K1WFI1"/>
    <dbReference type="eggNOG" id="KOG2412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422733_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFI1"/>
    <dbReference type="OMA" id="DVYTWIL"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="655" mass="73161" checksum="79E84AD8C6EEA48D" modified="2012-11-28" version="1">MRFAIPDPAEEELDYVVDMDLYSSSDDDLSGWVPDLSRRRRTKLGQSIRDMLLSSDSEDDSFVYPDLDSEDEVGDLLVASSSLPWREPLRTPQNKRKGKAKAPSSPPKPSSTQRTQPSSSTSPSKSKSKSHTPSKSKSRPRLPPLRSSYRWEPTMRDLIKDDTPSEFASWMKSTEEEAFREGHRNAALQKKRLQEIDRNVRHEMEMAAQGKRSREADELQRMMEGLALRQTQEEQDTSKRFHEREQKLWAEAERQLAEKLAAAAAEARRFKEEEAARIAAEEKAALARKAEAEKAAKEKAEKEAAEAAAKEKAAKEEEERKAAEAKDAQSKAAEQAAGTRAVDEWKKWVNVQRTMKEQVINVVKGDRAMKSSLRQGMRLITRGVGQVINTQESIVRVTKDINDILVSQLPSAPSAAQPTVLENLPSPQYGYLLSHLSKSLIKQAENEVSAKADAAFPLARIVVGLIMRGHGALADVLTARLVKKSPWVIPYFPQRTEGQPREEYEKSTGRGADESITDYIARQGGICTLYFAILAVPYQTIAPTLTVQPNPKQLCDLVPPILRQPAAWTWIASLLRGNTSALPPSAHLLCVLLDTAGFTLLKYYRQTDKLKEAIRTTSDNGRIPGDSEASRARLKLLLEGWDKKSLTEPSGLKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH86</accession>
    <name>K1WH86_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidylinositol glycan, class S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04849</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH86"/>
    <dbReference type="FunCoup" id="K1WH86">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WH86"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521940_0_0_1"/>
    <dbReference type="InParanoid" id="K1WH86"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57562" checksum="68875C516DE20A7A" modified="2012-11-28" version="1">MLSPLLPSRPAVLVGYDIDRAAAATEREDIGRRSTGGKLWGSNPQLTSGLPYPHKGLVHCRRGGHPEPARRHGADRRQARSDREEGHDAPLRVHIAVDESTKPEFPLEPYIQTDYGHLDVPAGTLVIPLTSRQTKDGMLGTHLKIAAINSIHNLLPANLPTVPNRALAYQPNVTLSFVVLNEDASEGSYVEGWDVEAAIRDHFKPTLEPLAPLFNFSIESQVLYHAPLTFEPTQQEDGSWAVDDEQIKVFVSEHWNLDSKSTNNPVLRFMLFVPSAKHRPMSLPGTDASDTFLLPQFGSVVILNPPSSLKEDASYHLTESALDQPFSQFTSDFYKLLAIPTLPEKLHPCPEKKATKTRASRGVSEPFSPWQLDTALRMRHLENAREARKTLGGIVRLIDKIEEMEIHAAVREKILGAIAKLEQLPAAAKEGVLASALLSRDAVGLANEAFFDPSMMGLLYFPDQHKFAVYAPLFAPIGVSLVAGLVKEIRAWKARKKAKKAQTEPAAASVTVEKDMPVQKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIH0</accession>
    <name>K1WIH0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="7">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIH0"/>
    <dbReference type="FunCoup" id="K1WIH0">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WIH0"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011302_1_0_1"/>
    <dbReference type="InParanoid" id="K1WIH0"/>
    <dbReference type="OMA" id="KVAKRCR"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000094">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="628" mass="68916" checksum="A4EB3719253FE661" modified="2012-11-28" version="1">MAASKTPQQIPLGSSVPALTNHAISVSLPLWEDNIGYEEGDPRVVGRMVTGYPRFFIHRSIQKLQALLLSKFGHEGEACMLFPSPRIASEARDFLASRSPPVASRTVEYVVTPGAKSLPSARQSDIDCIELQILFFAKDDFPAAKQFWQHTGDGITSRQAERALAFLGEAPAGASAPAACQTGKPVTGRNRHYARDSRYSTPQTPTTPTSPNPEEEKTISVPEEVAAADLGTYLEERYGRNLPLFNAPLAKQALRRRIAGGLLPNDADFDGDAHIKRGEVTPDDVYLYPGGMSAIWHAHDVARRARRNEGKPEGISACFGFPYTDTLKILSKWGPGCEFFGIGDDSELDKLEQLLDQQDPSEPLLALFCEFPSNPLVRSPDLKRIRQLADQHGFLVVVDETIGNFINVDVMPYADVVVSSLTKIFSGDSNVMGGSLVLNPKSTAYASLKKVMAESYEDNYWPEDAVYMERNSRDYRGRIARVNDNAYAITDYLHSRSLASGPGDNKVIKKVYYPRWETPENYAACKREPTAGKGGFGGLFSITFTDPAASRAFYDSLPCAKGPSLGTSFTLASPYTILAHYAELDWAASFGVEPDLVRISVGQEDEATLRAWFETSVRAAEDAVMAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WII4</accession>
    <name>K1WII4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WII4"/>
    <dbReference type="HOGENOM" id="CLU_1027399_0_0_1"/>
    <dbReference type="InParanoid" id="K1WII4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="35721" checksum="595F9FD4A81223FC" modified="2012-11-28" version="1">MGMWYNYTFARNNAANARCCPEGNNTNIGEWSFCSVVVGNGSDIFHSTSTTVNKCFVEKQNVTDLRLYLQDYPEHPPKASSSSRIAPKPLGVLACIVVALSLASLSLAQHQTIWKSDRPMVAVRADSSRPDAGTNTTDQNQDLNVYLGYIDRWKDDMMMKYGPSADHPMCTHFEPDDPSSWELDGEMPPIVVGPSGWGLEGGASGMEEGPSKGEHWYLNVTWRAEVPVTGNWTALQEKMRTAIPDDRMKRLRKEVYVPFVGDMFAFAGLPRSNYGQPAVSSSAVMIPGTFSECISQTAPTHRGNVSVPYWDRLFYFTALDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIN4</accession>
    <name>K1WIN4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIN4"/>
    <dbReference type="STRING" id="1220162.K1WIN4"/>
    <dbReference type="eggNOG" id="ENOG502SDFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1116417_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIN4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="28576" checksum="02019B8238FA60BF" modified="2012-11-28" version="1">MLPAGYLTPVEQRPNPDQERYKVFHALRNADLPCVVFFEDAIAFHGVPTCLFDLYLLVNDIQAAAEVLAKDAAWVHTEERKNKIGNSTVDVPQIRLGPPSDSSETATLFRVTHVVLLRAADWFYDLHDAEATLFPPLVPLLNAFYRVLFEGTQKQRRWTSLQLSYLHGHTLNWRNWKDQPRISLKELAEPARPVHQDYRDGYSFAEAMRRQTLVRDGKAEPGRLGTDFPPNPDYESRYGVLPGPWSWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIU8</accession>
    <name>K1WIU8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIU8"/>
    <dbReference type="STRING" id="1220162.K1WIU8"/>
    <dbReference type="eggNOG" id="ENOG502QPHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681621_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIU8"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="444" mass="47945" checksum="EF6914476C4BEB90" modified="2012-11-28" version="1">MAFRQLRAYRGDPRPQSYPQTPSDTFPSLPSVLLSNSSSEDRDGRSKSGSSSGRSRTEASKKKHDALKLSKGQSRETTSKKGSRHADVIDRWDPTGLGHAMWHHSGPYDAAAPSRNLHGPQTKAPMHAFSGPPVAPVAAPARQASAISIGTTPNPREDNGEQAVVGGRRPSGAAARRRSSGGLSNPYSSSLPASGGFFPDTHHEEAEEGDYARRERERQREEKYRAMKAAWGIDTPLRGLWFFATRRAGVPRSPGGKKIGFGGARSPPINEDSAEDFVGSHQSRGSFSRPGGGVKRTKSLMQRLKGMRGDRSHSPNKYGNNVPPLPASPGSGHERAPSAGRSLSRGSNGGARDSPTKGYGDELEPIQYGAVEGADAREELESELPARPAFPQHRSSSGHPVMPVMPEFDDLHQTRSNSYYEPPSGGDMKRKTSIVKRFKDKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIX9</accession>
    <name>K1WIX9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000318">
        <property type="protein sequence ID" value="EKD01384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIX9"/>
    <dbReference type="eggNOG" id="ENOG502QZ63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIX9"/>
    <dbReference type="OMA" id="YEWLESW"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37884" checksum="FE1A333425354EC2" modified="2012-11-28" version="1">MPVPTTTATTTTEQPTLKLRGAKTQASTAVFPDLEAKGNVIPRERAEAYVSEMYAWLESFGRGFDRNDRSTWKPEHLPIFERGGLYHRYGVGHEQFAWDIRSEPGVIDAFAKIWGTDELLVSFDSANISLPFGSSLRAELAKPWPHCDQSPARPWLHCVQGIVNLHENGAQDGGLMVLEGSTPLFEQFFAEHQDLMPEGGWSDKDWWDHKNDASLQWFYDRGCKWHKVEAGPGDLILWDSRTVHYGDVARGSEPRIATYVCYKPAADISAQMLREKQEAFENCWGSTHDPIDFRITAHHSPTRGWKLEEGERTMPRQRPVLSDRALQLAGVKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJ87</accession>
    <name>K1WJ87_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000315">
        <property type="protein sequence ID" value="EKD01484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJ87"/>
    <dbReference type="STRING" id="1220162.K1WJ87"/>
    <dbReference type="HOGENOM" id="CLU_442267_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJ87"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852919" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="67227" checksum="68BBA749D828BC9D" modified="2012-11-28" version="1">MLSMSLGAALTLGLLSSAAAQAPVLPNVNLDFNLTLPPGSILGTTRAWIIEYANTTTFDNNATLGSGPTRMVWNHSFDYDDVFGQAKILLEGVVRNAYVYGDMGHNEQPQNVTFWETDTTEVKNQVTPPEDGKGLLGKVEGLDAFRRSKIDPYGSYNWLWAVIDQDWGKRPGKPIIDEVIVTTAIESGAKSIDELNKTTLPFATAGKLSDHPAFYFRTWDADSNDTWVTTSTYAQRQRDGSSPIFAALSRECEAAASPLGGEAGGAVWVDVPANTSFIVVNGSRGPDFGFMNVGGTPIDGYVPIQTDTEQATYSADQMIWWRSLSPQVKYNISLGCNGTPQRPLFLTSVTFYKDMPPEPKKNHTGAIVGGVVGGVGGLLLILGVLAWWLRRKKRREHQKMQNEEDKFEIDGPVTPFEDPRPPPLRKVEGDPAAEAVRRQAEERQAREAREIREVERERERQISSTSGGSGSATPPSLKQQTLQALDTYDRYSPSSPHGPATPITGPNTPLTGYPSFMLGTPITGQSHANLLPTPPANGALLAIPETPVDGTLMASPTTPTRTRPRAIDVGAVDDGSDEDAMDPPAYNPEWTRPRTRPQRPRIVVPQNKTPSSTMTPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJS4</accession>
    <name>K1WJS4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJS4"/>
    <dbReference type="STRING" id="1220162.K1WJS4"/>
    <dbReference type="HOGENOM" id="CLU_1679203_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJS4"/>
    <dbReference type="OMA" id="AEGAWNT"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013243484" evidence="1">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="157" mass="14453" checksum="CCFB1A1463AA545C" modified="2012-11-28" version="1">MKFSAALVLVPLVAAGEIIVARQDNQNGAESVGSKVGNGAEGAWNTATSGAGGVWGTVTSGAEGVFGTVTSGGAGAWETATSGAKGAWDGLTSGVKGGWDGLTSGVAGGGEKATSAAGSAGNAAASGVKDAGAAAHNSVAMGAAVAGVAAGMAAVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMM4</accession>
    <name>K1WMM4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fatty acid synthase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000287">
        <property type="protein sequence ID" value="EKD02379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1WMM4">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMM4"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_6_0_1"/>
    <dbReference type="InParanoid" id="K1WMM4"/>
    <dbReference type="OMA" id="HFMDNYG"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2202"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2159"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2496" mass="275325" checksum="DDF76A50CA0D3895" modified="2012-11-28" version="1">MASLFSGPPPTRPLVLHSPAARVHILVPASPLSAWVASEVAAQEFHDSRIADDDVPAPVDEDDEDAVAAEPTNEPQVKLLARFLSFVADKVASEPSDELVQVLLATYERFNELFLSSENVLSLVQDYQPEVRAEVLTAYFKAFAALRKALGDSAVKIAHPAALLEAAKQGEAELYALFGGQGVNETYFDELQSLFNVYRPFVEEYLEKLTEQVLVPLAQKADADGFPYYSQGLDLIGWLRGTAARPTTEYLASIPLFARSSAVRTGHSQGLVSAIAVAASDSWESLEANIAKAVRLLFFIGLRGQEAFPIVAIEPEIIADTTANNEGTPTPMLAVNGLSRKALEGHIEKVNAFLPENAKVGISLFNAATMFIVTGPPKSLYGLATALRKVMAPAGLDQGRIPFSKRKAVFNIRFLPINVPYHSDYLQGCTERLLKNDFSDDWSASELAIPVYNTEDGSDMRKTAGSIAESALDQIFTKHIHWAKACNFPSTATHAVDFGPGGNSGVGFLVSRVTEGRGVRTIVIGEKGAAAAEFYDANKVRSEPAWQREYHPRLVKTLDGKINIDTPFSRLLGKPPIMVPGMTPTTVGANLVSATLNAGYHIELAGGGHFAPFILRAKVDELMRRNKPGLGITVNALYINQPQFTFQYPLLQEMRREGLPIEGFCIAAGIPSSDKATEIITNIKNAGLKHIAFKPGSTEGIRQVVNIARANPDFPIILQWTGGRAGGHHSAEDFHQPIISTYSSIRKCPNISLIAGSGFGGAEDVWPYICGDWSTKFGLQPMPFDGVLYGSRVMVAKEADTAPQVKKLIVEAPGVDDSEWEGTYDKPTGGILTVRSELGEPIHKIATRGVKLWREFDDTVFNLPRNKRKAWLESKKDYVIERLNADFNKPWFPMKKGGVAVDDLAKMTYEEVTRRMIQLMYVESDKRWVDISLRNLTGDWLRRVEERFAGVDGIRTKESLLQSFSALDDPIPTVDAFFNHYTKGKEQLIGAEDKAYFLSIAGRPFQKPVPFIPVFDDNFEFWFKKDSLWVAEDIEAVFDKDAQRVCILQGPMAVKHSKVVDEPIADLLGNIEGLLTKYILERYYDNDESKVPTLDYIGARPSQAHTMYAKESVEGGARYLSLTDKLPRVEDWLQRIAGPKLSWLRAALTTPNVVQGKKYATNPFRRIFAPRKNQTVRITPAEGEPEKVEVFGAIRSAGNSPKDFKAVELSFDRKTRVITMQLNEERLGSSVPLTFTFEYKPEQGYAPIHEVMEGRNKAIKDFYWRLWFGDNEKLPSLPLDNTFTCGATTVDPATIQRFCDVVGNQGEKFKAARNNEILAPMDYAIVLGWQSIMKTIFPEAIDGDLINLVHLSNGFRFIEGVAPLKAGDVCTTEARVTSVTNSDSGKTVKVKGYVLRDGEAVIEVNSAFLYRGKFTDYENTFETIEEPDYVVKLDKPTSVGVLQSKPWFEWDDDSVPLDIGTELTFKVKTKLTFKDKSTYQAVKVTGAAFIRSQTKQLVQVATVDYEAHNSKGNPVVEYLKRHGKAVGLPVPLESGGYSLITDPATATYRTPSSNENYSKISGDFNPIHINPYFSDFANLPGTITHGMWSSAATRKYVESVAADNHPERVLSYDVNFVGMVLPGDEINVKLTHTAMRDGKKVIKVEAFNQDGQKVIDGQTEVLQPPTTYVFTGQGSQEVGMGMELYNNSEVARAVWDAADAHLTSTYGFSIIDIVKNNPKELTIHFGGVKGQAIRQRYMELTYDSIDENGQVKTQPLFGDIDLYTTSYTFSHPQGLLFATQYTQIALVVTEKAAFDDMKAKGLIDQNAPFAGHSLGEYSALASIADVLPISALSDVVFFRGITMQRAVKRDAEGKSQYAMMAVNPSRVGKSFSEPALREIVDQISKQKEVLLQIVNLNVADQQYVTAGELRGLATLTNVLNMLKHQKIDLEKLSKTMSVEQLKEHLTEIINGCWDMMEEKKKKDGGQVNLERGYATIPLPGIDVPFHSRYLWPGVLSFRNYLIKKIDPEHLNPDRLVDKYIPNLIAEPFEVTKEYVQKIYDETNSPRMESVLKGWESESWASPQNRQRLAYNILTECLAYQFASPVRWIETQDVLFQKAKFERFIEVGPGPVLSGMATRTLKAKYEAQDGARSLKRAILCHAKNQKEVYYAFEDEAAEEAPAAGGDEAPKEAAPAPTAAPVAAPVAAPAASAGPAQQVEDAPPKAVDTVRVIVAQKLKKQAGDIPLSKSLKELSGGKSTLQNEILGDLQTEFASAPEKGEDLPLDELGAALSVGYGNLGKHSMGLTNRMIASKFPGGFNISAARNHLNKTWGLGPQRADAALFFGILSEPPKRLGSEAEAKAFLDSIAQSYASYSGITLSTGGGAAGGGGGGGGAVMNSEEFDKFVAKQAEHVEREIELLHRYLDRDGRAGEKKAENHKAEAEALQAKLDAIKLEHGDAYIDGIAPVFSPLKARTFDSSWNWARQSSLQLWYDIIHGRLDPSTIFESEPRYRPTERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WN85</accession>
    <name>K1WN85_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WN85"/>
    <dbReference type="eggNOG" id="ENOG502TIZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692647_0_0_1"/>
    <dbReference type="InParanoid" id="K1WN85"/>
    <dbReference type="OMA" id="PCLAVID"/>
    <dbReference type="OrthoDB" id="2563736at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="37035" checksum="FC8A33B153D494B5" modified="2012-11-28" version="1">MDFLPAVPRDVPKQLYKAELTLSVGGGSRRGSTSSDGGQPTGRRMSLAALGLGGGGGHQAAQSNGKQPETHTEGVWYWPCQVGVTDCDGSTSERDSIELLRKSGTQCIQPAPRSIPSLGAAKRSLGGSRANRHSADMSHLQSNQQSNQHLSASPPKDSAMGGKFMSGVRRLSTSFGGSKPAHTQTQTQTTTQPDDSAAGMGASHPTSTTAGATGMVNEARRDSSAGVSGGLGGGPGEEDARETGWPGVVDGEALQAIVVPLSSVGKASLDASSKEGSVVHVGVKSAVNGKSGTPAFSFGNDWIGGKGEAEVLYRRIEGGVEKAKPMFGGDMFKLGSSRTHGADKQYNDQWRADVRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPD6</accession>
    <name>K1WPD6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_02760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPD6"/>
    <dbReference type="STRING" id="1220162.K1WPD6"/>
    <dbReference type="eggNOG" id="ENOG502S4YG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495390_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPD6"/>
    <dbReference type="OMA" id="EYDINRP"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="120"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="370"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD02929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="535" mass="54377" checksum="04C3EFEAD98B1B31" modified="2012-11-28" version="1">MGFGRLLRRAHNALAEGTDRLAQSSPPSVSQSEQEFEHDLNERILTTRFTTPGGVPSSTSSQTRRPVLVFFDVSQITASPGFPENERLIGQESFKMPDNSALDADALLLLLPTLLPRSTSSPLPHPTDSVAALVHTIHTQLGFRLLPSPGTAATDAGSSSAGGPAEPESSGNNEDDDMSETTTAVDPNEDTGSGVANVLPAGWNARGEDNYTFEYRHEQSSMTFRVRVGRMGSRITVDGMAEDSAPHSFSLPVGDIVNAGLFPIPSAATAATAAGDEQDAARALGFVSRDAVNRFTSSYDSSVVSRLVPGLSKEGYTAAAPSSAPRGPDERRRPRPTPDNPTGPEPARPGVPSPLIDPLRGPGAVPAASVGHRDLDPLGSMRGPDSSGGMVVDFNHPLFAGRRGQGSGEVPDPSHPSGARWDPVGPHGPTGPRFPGGSGGSNPLGGVGVTDPEWRNRFGDEMPPPGEFGPDMGLGPFGGPNAGPGGGRFGGAGGGRFGPGGPGGLGGGFGGGLGGGGGGGGFGGGGFGGGGGMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPI3</accession>
    <name>K1WPI3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD02974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPI3"/>
    <dbReference type="HOGENOM" id="CLU_515047_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPI3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="489" mass="53763" checksum="2BC7BE47297F56EB" modified="2012-11-28" version="1">MAIQRLSSRAAAQRLVANFTIDGVSPFHNIDPQWTYEWSDDEALFHRTTPLQPSDSTSFRINFVGSSFRLIGRISGSNASGSVNGGNPSTFVTHDGMTELLSDVAANNTLVQVEVNYGPETFIEYNSLQYNMTIVTEAGSSEVPTLLNGELNPSIQVSTFSSGDIFQDVQSELPSEPDYDLRNGETVFLKRMTELHYTVPTNVSLLQVQGPVMTERQNLSVCTAVLDPLPAWWNASTGPPMAWQAAPLNISFKNLFLFPLDPTVSYTMKILPRYDGKECGVNMIRTYPFFYNPRNEHQTNSPTIPSGDGSESGHQGSNHASIIVGAVIGGVSFIVIVTSLIVWLIRRYLRRQRESALPDLFLVDEGDPILNPFIANGITRTCPEETGPRKREPPTGRTSGTNQLPPVHALLVQEEDAEDVGDENHPVEVLPPRYRSGRRNPITRGSDAPVIPSGKQALRTRNPDPPSRPSSPASTVYTFYPARSTLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQT2</accession>
    <name>K1WQT2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymethylenebutenolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000252">
        <property type="protein sequence ID" value="EKD03409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQT2"/>
    <dbReference type="STRING" id="1220162.K1WQT2"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="InParanoid" id="K1WQT2"/>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="250" mass="27747" checksum="4CB6DF8B2F5178C9" modified="2012-11-28" version="1">MLIKTSYRDVETKADGCPGKMRIFVIEPNVPEYPEAKFPGCVVFSEIYQVTGPVERFASNIASEGYVVALPSSFHEFEGPEPIPYDTEGTDRGNRYKVSYISRSEADCQIEKTVEAYDEQCAFDPRVLSTFCYFATDVHSATLGKGKKDDTLVRVKKGDLTGKGEVTLVFGKQDTHVDRAGRTLIRDTLDDAGVTLSAQHAFIRDESSKGRWDAALSRSLFAMMMESFTRCVARDLGKRVPTGGKVEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRC6</accession>
    <name>K1WRC6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRC6"/>
    <dbReference type="STRING" id="1220162.K1WRC6"/>
    <dbReference type="eggNOG" id="KOG2731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1005400_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRC6"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="302" mass="33143" checksum="7F0667EF2BE6F242" modified="2012-11-28" version="1">MVSTEGTHPAFRLAEKHFKNRTTNALPALRNLPEYTQAVLDLSGPPDQSSDPVWQAGWWGAEYTEPTPQRRRRKGKERAVGERGERPVMDLDGVPCLHLKDGRTAYLVAEGELQRRVLAENRLCSDPPIPRCRGAAPAPRIGAVRVYPPAQPLVARYALRPPPEPVRALRHRARHARAAKTPRPRSGGESPPRGRDTAYPPGTDRDSPSVANRLRRGEAAQRDVDGRRAEPESRVEDGGPARKGGAVGEPRLGVSVVHEELRFLDRRADPLPRPASCALSQGRAGHAVERCVSQRVVPSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSC8</accession>
    <name>K1WSC8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSC8"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="K1WSC8"/>
    <dbReference type="OMA" id="DTHGPRI"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="460" mass="49511" checksum="7E53ADF8E997BE37" modified="2012-11-28" version="1">MNPSDLEKGHSSPPSTAGYHADTEFPPKHEHPHEHPHAPRDGELALAETSPASHPPPGVGPAPDGGFWAWTTVAGGYLAVFVQFGLINTFGVFQSYYEVNQLRDYSESEIAWIGSVQQLILFFVGLFVGRVFDAHGAHVLLIPGGIIFVLSLMMTSLCKEYYQFFLAQGLLFGLGSGLIFYPAIAVPGHWFARKRALAMAIVGSSSGLGGTLWPIALKRLFDEIGFEWAIRTVAFISLFLFALSWCMVRTRLPRKKPTPWRAFWHPLKESPFLLMTACVSLVFFGMYTPFFFASNRALELGASDSLAFYTIAFINAGSTIGRLVAAVGDQWGAFNVLIVSALGSTLSLLAFWIPSVKLGALIACTPTYGFFVGMFISIIPACVALTGPASEIGLRVGLLWTIVAVFAFTGPPIGGAIVGEHPGELGYQLAGVFSGIVTFAGLICGMGSKIKIGGSLWGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSN8</accession>
    <name>K1WSN8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Longevity-assurance protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSN8"/>
    <dbReference type="FunCoup" id="K1WSN8">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSN8"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_2_1_1"/>
    <dbReference type="InParanoid" id="K1WSN8"/>
    <dbReference type="OMA" id="GYPHIPL"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="99"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="392" mass="44027" checksum="B6F82541D70F9B94" modified="2012-11-28" version="1">MSLTRESVVDFVRPFVELSYPVKGFENGVPTTLYSKGRLDVRYVIFWAVVFSVLRHVSMKYILSPLARRVIPTPPLDHKPTSPAMERHLKRVAAKKKEHNSVRFAEQAWAMAYCTVFWTIGMIILHRIPNPTSPEQLWGTYPYTPLPALTKFYYLAQLGWWFHQLYVINTEKPRKDHWQMFGHHLLSIALIGSSYLANYTRIGVVVHSLMDFCDILLPLLRYMAFSQACDAAFVVFLVSWIVTRQVGLFLVIKSAAVEAPKYIAFKWDPANGHYLTKGMYYGFIILLSILLVLCTVWFYMAIMVAVRVVRGQGAEDTRSDSEDTDDDAISLEDEDDGVIPNGHTNGVNGHANGHANGNGVTNGITNGNGVNGVNGHSSAVNGHANGLKNRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWZ3</accession>
    <name>K1WWZ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWZ3"/>
    <dbReference type="STRING" id="1220162.K1WWZ3"/>
    <dbReference type="HOGENOM" id="CLU_2185781_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWZ3"/>
    <dbReference type="OrthoDB" id="88410at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="109" mass="11776" checksum="8639C76173FAC57C" modified="2012-11-28" version="1">MTGSRPGGDAVSTNADTRKRLQSTPLLPFLLPSPSQRLGRLDLSSPKLLEWCGADRPGHHVESVLKDVPVADRCDCPHVPIVDLPGLRLMKTVKKDPNYAGGASKKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2S7</accession>
    <name>K1V2S7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_07506</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2S7"/>
    <dbReference type="FunCoup" id="K1V2S7">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2S7"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_6_1"/>
    <dbReference type="InParanoid" id="K1V2S7"/>
    <dbReference type="OMA" id="FHDEGRV"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="206"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="285"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="334"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC98174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="474" mass="53103" checksum="6736FA9D7F4B9B10" modified="2012-11-28" version="1">MSQLPQMMDSLSLSSSSQLQPPLLPNSAKANRLPPLMKKYMNPGLVRPPNTGLAQHQSAALLSMANASAGTMPSGIPKPSPKKAGSASVTSSPARPRQFTANTGSIKVVKPLRPSHTVASNYAKDGRVERERERDGKEHKEHKEPKGDKGDKEKEREKERDAIGTYDGGLERDAAQKGEVTGEAASLLAMSSTSPSSSVHLSLHSFQIGRPLGKGKFGRVYMARTKAAPHFIVALKCLHKSEIVAGRVEKQVRREIEIQQNLRHPNILRLYGYFHDSKRIFLVLEYAAHGELYRQLSKCGRFDEKRSSRYIAQMADALQYLHRKHVIHRDIKPENLLIGLKGELKIADFGWSVHAPSDRRHTLCGTLDYLPPEMVEGKEHNAKVDLWALGVLAYEFLVGSPPFEDLSGPQATYRRIRKVDLKIPPHVSEDAADLIRGLLKYNPQDRMPLSDVLEHPWIKRYEKRSRASRPDREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1V355</accession>
    <name>K1V355_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33503"/>
            <dbReference type="ChEBI" id="CHEBI:6076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33504"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V355"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="K1V355"/>
    <dbReference type="OMA" id="QILWGEK"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1194"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="130"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="834"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1457" mass="161355" checksum="C85B3C3CE5D54E17" modified="2012-11-28" version="1">MSEQTPPEAGPATAPAQDGQNSRHDGHNEDEHSNKTSATTLPKFNDEEWTYEKQLKADQAALESRGLDAGSGLSLIWDHLSLRGVGGAEDVRFASDFGSMLMPWLAWSARKRSKALNRVSNSHDRSMHWNKGDPVPKRGEPGLRKGERYLLKDFSGALLPGEMMLVLGRPGSGCSAFLKTLAGQTAAYAGVEGAVHYGDVVPGSAEARRMAAEIIYVGEEEDHDPNLLVGQTMDFAARMNVPAKAARPLDAAGEPVPAADFEEDNKQHLLRALRVQQTHDTKVGNQYVRGVSGGERKRITLLEAMTGPTQMMFWDNPTRGLDANTAVLFTKLCREASDVANRINVMTLYQAGNGIYEQFDKVCVIAEGQVIYFGPRAQARAYFESMGFVHAEGANTADYLTAVTALNERQVAPGFEGKVPNTAAEFATAYRASDTYRAMRGQVDALLADQETRRTETEAVERTVAAQKARHAFQALPQRRSYLAQARATVIKDWQQRWGDQWSFWARMVTTFVQAWIVGSVYYNVPDTTSGLYLRGGVLFVTIFYPVVLGLSELHAAFQDRGVLAKHKSYNLYRASTVILAKAIVDAPIYAVQNIVYVAICYWMAGLRANAGFFFTCFLFTWLVTMVFSTLFRSVGYAFNEFNDSSKVAGTIFIFFVVYGGFVIYVPSMKPWFGWIRWINPLYYTFEAVISNELTNMDLACAPPELAPYGPPYAGMPQGCSVVGNVPGSTTVSGTAYLRTALHMNRDHVWRNFGIIIALWIAIAALGMFFLEILPASGSKQNVNLYKRSGGPYASKKTPPADEEAGVVEKAPSKASQVSSTAGQLGAEGKQTTFTWSDVCYSVKTRSGSDLQLLDHVSGYCRAGTITALMGSSGAGKTTLMDVLAARKSDGVIEGTVKLNGQSLPVSFQRTTGYCEQLDVHLPQATVREALEFSALLRQPRRFTNAEKLAYVDVIVDLLELGDIADAIIGEPGKGLGVEERRRLSIGVELVSRPSLLFLDEPTSGLDGQSAFVVVGFLKKLAAAGQAILCTIHQPSAVLFREFDQLLLMIRGGRTVYFGDVAKLPDYFRSKGVAWPEAKNPAEEMIDIVSGDESMGRDWAAVWLQSEERQKMLADIEEINATVRPAGDEEDGYEFAATTWTQLRVVTRRACIQIYRNTDYTRNKMVLHGATGLISGFSWFKIGNSLADLQNRMFSLLMFVFIAPGVMVQTQPKFIKNRDIFEARERKSKSYCWQVFCFAEIFAEIPYLLLCAFIYFVCWYFPSGLDLSAGVAGPVYLQMTFYEFLYTGMGQFIAAYAPNPTFAAEVLPLFFGILIAFTGILVPYPMLPAFWRYWMYYLDPFQYLMQGLLTFPLWNAPVECKPHEFGLFDPPPGLTCGKYLAPFLTYATGYVNNPDATAACEYCAYAKGSEYLGNMNIKRKIDGWKGILITLLFCFSSYGLVFLLLKLRSRKTKTAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V367</accession>
    <name>K1V367_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V367"/>
    <dbReference type="HOGENOM" id="CLU_1579623_0_0_1"/>
    <dbReference type="InParanoid" id="K1V367"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="180" mass="19407" checksum="93B2EA6AD431781C" modified="2012-11-28" version="1">MSATATAAEPAPPLYLTPPVLLAALQTAIEQLNAQLEAERDVLFDLWDNLSITLYAKRGTGPGVAAALDTILQLALQGLQLRFAVRVSAIAELYLETESVLEACHDEGYHEAGERYLAHVLETFAAQQGIWMAVLAAATPEEGTDPVVAWGEFVSSLALPDDELEDESSRDEELEGQVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4G7</accession>
    <name>K1V4G7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4G7"/>
    <dbReference type="STRING" id="1220162.K1V4G7"/>
    <dbReference type="eggNOG" id="KOG0002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556373_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4G7"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="172" mass="19381" checksum="EF82580C369BAF53" modified="2012-11-28" version="1">MPSQKSFIVKQKLAKKARQNRPIPQWFRLKTDRLYTTRGRVVWLAPGESLSAGLGRLRGRSFDTLMRVKILSLHSSPQYSLQPLARALSLISSIRFSTSIQLYDHLHLHKSARHAIFLSTLPTARALLVRMNERNHVRMFIAVSSRVAVAVPVSRPQAKPSSPSYQVPSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4N3</accession>
    <name>K1V4N3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4N3"/>
    <dbReference type="STRING" id="1220162.K1V4N3"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="InParanoid" id="K1V4N3"/>
    <dbReference type="OMA" id="FPMESIT"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF393">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="245"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="700"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="802" mass="87211" checksum="726F647813AA14A9" modified="2012-11-28" version="1">MSSTTSSSTSRKGCRPEFSRPLEWLSGSNGHDRTCRVPSDPRGVGPGELAIAHSYLQLTGRSPQGTERPKAGLTTAGAHPPGAMVCTLLDISTDSANSLTPLSSVTCALCTPYKPSLYTSDGRRIRVIERIMAPTPSYDEVDAALCRPGTIFEIEEKMIRGCKIKTWKRAPVHFRQFFEERMTKWSDRVMLSTPRAESLSEENREVLTYGEVWERSVRLAAWLRDRELDDFVWKRAPVHFRQFFEERMTKWSDRVMLSTPRAESLSEENREVLTYGEVWERSVRLAAWLRDREVRAGTRVAIGGRNCAGWMISFIAVCLLGAVPVLLNSTLIVDAQLHCLGLTKPVLVLCDPENASVLGSVASELTARGVGPIHCWSSLSHVDPAVRSNVSELVPGFAVSSKSLDEVRSGKGFGLEDVTPESDCMVLFTSGTTSMPKGVLETQRACLTHVISSSIPAARAIMRMGGTVEMALAAHDPPEQQGAMLLAVPLFHVTGLLGWMSRGVHMGMKMVFMKRWSTSAAVKLCVAEKIGVIGGVPAIATAILQSPELPSDHVMEGITYGGAPPPARLAADIQKKWPAAMATHAYGMTETAGLHTGFMGPDYHANPACVGPAMPVDEQRIVDPETRKVLGPNQPGIVECYGPNIMKEYIDNPAATADALRDGWVHTGDLALIDDNGFLRITDRYKDVIIRGGENIASAEVENAVYADTRIAECAAVPVPNNVLGELVAVGVSLRPGATATARDIMAQAAARLRAPARPVFVHVYDDALPRNANGKIVKTDIKTLVQELYLKDIAENGRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4S0</accession>
    <name>K1V4S0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4S0"/>
    <dbReference type="FunCoup" id="K1V4S0">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V4S0"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_0_2_1"/>
    <dbReference type="InParanoid" id="K1V4S0"/>
    <dbReference type="OMA" id="KSDLHAR"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="178" mass="19505" checksum="043CC10B256ECFD2" modified="2012-11-28" version="1">MCQLIPQPLVICGPSGTGKSTLLKSLFAKYPDAFGFSVSHTTRSPRAGEVDGREYHFTTKEDFMTRVEREEFLEWAQFGGNWTPPLNPVFLFLAPPSIAHLKSRLRGRGTETDDSMGKRLAAAKAEIEHAISGAHDLVIVNDDLERAGRMLEAVAIGAPGWEEVGDELPALDVTELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V684</accession>
    <name>K1V684_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V684"/>
    <dbReference type="STRING" id="1220162.K1V684"/>
    <dbReference type="eggNOG" id="ENOG502RYE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_343939_0_0_1"/>
    <dbReference type="InParanoid" id="K1V684"/>
    <dbReference type="OMA" id="ASPINCH"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="436"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="823" mass="91432" checksum="E87EFF14F7083D5F" modified="2012-11-28" version="1">MSGQSLPPLDLLFPFPSPSSDSFLTLSTPPDTVLASPINCHLSLDTLDALDKLDQQDKLFTPQPQPTINPNLTHAHLPSIHNDIFTTDKPRPKPIESVKQQSPEVKPDTSKTTPSPSPPKRKAKELKDKDSKDSKDSKDNKKAAKKDMDDSHQQPPIRPRPIAAAANSSTAPAIASSSTVLIERRKRGRKRYSCAECRRERVDKEAREREAQAAAAEKAAAEDPKPTQSPRVATSPLRKLAHSFEKCVVDTTPGQLRMDEDGQTRYVGSLAGSVYLREDQDADRRPSLNGASDPGAGDVLQAMGTPTLRRDPVADARSKLPPWKEGRRMVEQYWEHVNWIHQVIPKITFDKYLIMAYDPSAQPQSAQLACVLLVMALGVMFDLTLPPFHPRCHELFFAAQDLLSATRSEKPSVTRIQALSLFGTFVLNDQNGAEAFWPIIGSTLKSALTVGLHRDGEAFGLPEDEVQERRKVFWELMEYDRVQAMTFGRPCGLSNRHMDTKMPIPDNRLFFDDSGYHHAKHCVVQMLERVNDTQVQPTPVPYTTVLEIDAELQEFRKSLPESLMCSIAITDLPMNAHPQTVLQRLGIRLFISEARLHLNRGAFVQALKENSTAPSRGTFGESFIALYESAQEIVQVVKALVLFSPALAERWWFFWFHAFSAAVCLAAISLEAPASGFATPAYSGLSIVCDLSAAARDGSRVRDGLNTLLQLRKRAQERLKEGVRSPGSEDDEVRRLLLAEQREAQPRRRVSPPGARDQQLLQQPQFDMSAQQGQGQEEMQGMEEPIVSTGPIMPLWPDAASALEYGLALDALGLNVFDWDQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6I5</accession>
    <name>K1V6I5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6I5"/>
    <dbReference type="FunCoup" id="K1V6I5">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V6I5"/>
    <dbReference type="eggNOG" id="KOG2409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009647_2_0_1"/>
    <dbReference type="InParanoid" id="K1V6I5"/>
    <dbReference type="OMA" id="WDNYDPR"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="542"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="745" mass="81588" checksum="31861ED323AB5C28" modified="2012-11-28" version="1">MVKAEAAPAKREPSPAPSSSSSSASDVSDSESDYSTTDTEEDDDGAQLTPAMDAAILRTLAKIKKGGEELYAGQNVLQSELETARKAAEARGLKVASEKKTEEQPFLLKDLHRQNLLEGVAADSDDEGEPLTFVEETRRARDDAVNAFKAFAGSDDESEDDLLVKREKDADEAEEDDEAYRRFLLEMGGGEEEVRAALGMGPAPMTNYREDSDDEEDFFRAESSTADAEKKDKKEKKKSKKEKKSAEAKAAARAKADDHYILNRGWIEKKADKSHVPTYEEIVGHERPEGEASDDENAPWGALSEDEEFEDRAEEFETQYNFRFEEPGAAEIISHPRQIESLARRDDDKRKLKREARAERKAAEKVEREAETKRQKGEKRREMEKQLAALKEEVGDADVDWTAVEKVLEGEYDEGEWDRVVGEMLAKAAESDDEKPTWDDDDDGDYPMDEEDAGWVEPQAWEETEDWAAGAGEDEEDDGPINMDADFMDDEPAPKKKLSKKEKKKAKKAAAAAAAAAAGAGGAAGEEEDDEKLSVAERAARVKAAADSLRSLDHEDSIGDLKTRFKYVKSAPSTFGLTPAEILLATDAELNELVSVKALAPYRRGGLGRAGYGLGRRVRDLKARLQGRKWGEEPEPESKKKAAKKAGGGEGGGANAIPLGKGKSAEGRPGKRLGRKEREKLRAAAGGEEGEGAEAVAGEKRKRQEEPEPEPAVEARTEVVAEGGAGDGEKKKKRRKKKKAAVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8H4</accession>
    <name>K1V8H4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8H4"/>
    <dbReference type="STRING" id="1220162.K1V8H4"/>
    <dbReference type="eggNOG" id="ENOG502R512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322627_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8H4"/>
    <dbReference type="OMA" id="FRYRMTF"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="893" mass="97731" checksum="E0E923F004013884" modified="2012-11-28" version="1">MSTAGEGIMSPITDPRPDASKNDAPPNPPPKKTPGGTGPKKVDVSHFPHYGLKRGMACTFCRRRKLKCSGDRPMCTNCTKYNKVCEYGPPVKAPKPPKNPPPQALYDVNGNQHIPGMVHPQPDNAAANGMSVGMLYTGEPPSSFDFIGQGIPDPGPMNSMPMPNMPPASLGNDLNGMNSFSANLSTPSPFVADQAQPIIGMPPYVPSTGPEVYYDPAMWVPTSADGVPQQVFDISQMSGAPEPMQAQFQSPMEAQGSQQAQQTQPFASNMNTDYQQPMFESPAPSAQSRQQSVLTTSSGGSRVGSAANYITTVSDPPTPDGLGAVSGSTPNSEDNASGTERPKASRMYRQTASIYVADAGTNVDGLTERLGEFLFSPNSSAVKDDEQIRRRKKGSGNVLLKPDGTSVKRMRAEYDGLLDSFRSILLDCFLAHVTLFFEMSVPRFRYRMTFADRRRPSLALLNTMYLWATRISNAPQMSNMEKQFFEQACTHLDISTSTVDRLIDGVRAAMLLSAYSYASGRHHEGWCLGGLAVRVAVSCGLHRISSMTLRPPPPRNPFLRNQHFLLPPPEDAVELGERIHAFWAAFSIDRAGALATGYPSGMHDDDIKTPFHRPLADISAGMVSEIDDITVKDLFLGNVGDTQRDNHYIRWLKVVIILERASKLAYLEPDDDSPYSQAWNKYHLTLHRDPDQPKPPAYLDQPKYRNPGRFRGCLLAIEQFTNCLGEDGVFPVTRRAHAEQDGQPEPEITPATLMLHHMIAAVHMVLHDINSLEVENTEAVMAARRSVTLFRAVPPIPFTEVDAFVVLVWSMIAKVLIKEAHRLTLVGDSENANITAGDADTAIAEIRRIALTMHLARTQANALDELKQAALSAGPQPGLSSMSLEQFMFPTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8J2</accession>
    <name>K1V8J2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8J2"/>
    <dbReference type="FunCoup" id="K1V8J2">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8J2"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="InParanoid" id="K1V8J2"/>
    <dbReference type="OMA" id="VCIPLAP"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.420">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="7"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="24873" checksum="6BDB1989057888B1" modified="2012-11-28" version="1">MDAMRTAETPVPSELTEQWSQPLGLPAAPLSFQDLFSLDPEFLAFIPQPVRAVLLLFPQRGALAQAREEEEKSDEHKFDGDVWWVKQTVNLQRVRLDRTPARPPEPARGQPGAGKQAGPVQAMARAKLLETSPFFESAHESASQGGQSAVPENVDVDTHFIAFIEAKNKEGDNRVVELDGGRTGPFDRGHCDDLLSDVAKIVKEKYIDRADGDINFNMIVLAGQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8L8</accession>
    <name>K1V8L8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">F-type H+-transporting ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8L8"/>
    <dbReference type="STRING" id="1220162.K1V8L8"/>
    <dbReference type="eggNOG" id="KOG4103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118199_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8L8"/>
    <dbReference type="OMA" id="NMTPPNL"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20533" checksum="8FEBEEE51C2458CC" modified="2012-11-28" version="1">MFRPQVARSARTLGRRANSTTAQQAQQKAQQAAQDAKQAAGDVAAKAKDALNSPKAQEVSQKANELFESGAQAVRKVTGPIGDKVGNALGSYKQPLQYNWQVFKSLVKQVYQAEKLAPPTHLSQWTSAYSEIFHKAASKQWWSQVLSSGSWAKLAVGGLEAYGLYKIGEILGRRHLIGYNVPANAVGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1V947</accession>
    <name>K1V947_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Retrotransposon nucleocapsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_08482</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1V947">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V947"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238385_0_0_1"/>
    <dbReference type="InParanoid" id="K1V947"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chromo" evidence="17">
        <location>
            <begin position="611"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="857"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="1401"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="17">
        <location>
            <begin position="1698"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="212"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1769"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1779"/>
            <end position="1790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKC97200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1790" mass="202415" checksum="AB21A8CD6BF395E3" modified="2012-11-28" version="1">MPTPTDNPDSAHEQQFSRDEPPHLPHLDHNSRVHRAEEESMHRTDQQGRTRAASRALSNAPHEPMAPQTTNPASDEQNPSNDNYLGSARITTIQELEFANEDHNTRTNNTPDNTENHNETRNNTPSQGTTGQHPSLTNTTRAHEAPMNREPHEFENTPAGSVIERDRSPTAVHSNVPNAAGHDQSQLNHKILESLQTMGQLLSHLSKDIRSLRPDTSSAGDIGLPPTHPHLQGARHSSTFSRPLSNSAAGYSFSPAPATDSRTEERRHASERLASALPYPSPWGGTTDDPHKLRSPSVPNPEKFSGDSRKVRGFVNDMSTYFRFHERFFDTNERKVEFATLNLTDDAKAWYLAETGQTAADSVRVDRIAERWPCRERRHGLVGLPGRVILPLPTDVPLSLAADHTAAEDADRLRPVIRQVRGNRPRRTTNRRLYCSFAQTDWDELLSYAEFSYNSAPQSAIRCSPYEALTSHSPRTSLSVPPTPYTGDVPAAGRHAIRMAQRHRQIREFIVQANQRYADLHNKGRRDLHFSRGDYVYLRNTNIKGLRPSRKLGDKYIGPLEVLEQVGRASYRLRLPPSAAIHSVFHVSLLKQAAVRGSPRPVPADLADDGPQPVRILSSRVVRGQRQWHVGWQGEDDPSWETDQTMSPFPAWPTLRDSYKPQRGKRESRARSQWLGWESQLHITFFTTCTSSPPIPRPSHSSSPAASNLRLREEVTATILVGQGFEPYKGNFEIHKIASPFCVLGVPFFQTTGTILDGRTMTIKPRPNSSISALTTNGTNDRNTRTAEEDAVCAVLPTQYHDFVDVFLKSSAESLPAFSKFDHAIDFIPGRSPKFGPLYATSPLKARAIKAYLDDMLAKGLIRVSDSPTSSPVLFVPKKNGESRFCVDYRATNAITVKNRYPIPLIQDLLDRLSSAKVFTKIDLRGAYHLVRIRAGDEWKTAFRTQFGLYEYLVMPFGLCNAPATFQRLVNHVFHDLLESCVVVYLDDILIFSEDNASHELHVREVLQRLRDNALFAKAEKCEFSTTSTSFLGYVISSKGVTMDPSKTNTIASWPYPRNAKDVQRFLGLANFYRHFIPLFAETCVPLYALLKKGTRFALTPDVKSAWDDLKKKIAGDAVLAHFDPQSQCVVETDASDYAVGAVLSQEWEGFLRPLAFASRKMSPAELNYPTHDKEFLAIVYAFEQWRHYLECASVDVQVYTDHRSLEYFARDKMLNRRQARWADFMTDFHFTITYRPGRLAIKPDALSRRPDYRPFDTDATSTSEELNPFYRQRVLHPGQFLNALVIAAESDLRGALLRESDAVTAAFAKQHNLRRRNRLWHHGTKIYVPDSLRDRILGEYHDAITAGHPGVRRTASAVSATYWWPRWREYVQSYVDSCDACQRTKIPPRKPLGLLRPLPVAERPWQHISCDFVGALPKSNGFNSILVFVDRFTKMAVFVPTTTSLTAEGFAKLFIRYVFCRFGLPSSLVTDRGSLFTSRFWMELARLLGVDHRLSTAAHPQTDGQTEIVNKALEQFLRLYCSFAQTDWDELLSYAEFSYNSAPQSAIRCSPYEALTSHSPRTSLSVPPTPYTGDVPAAGRHAIRMAQRHRQIRDFIVQANQRYADLHNKGRRDLHFSRGDYVYLRNTNIKGLRPSRKLGDKYIGPLEVLEQVGRASYRLRLPPSAAIHSVFHVSLLKQAAVRGSPRPVPADLADDGPQPVRILSSRVVRGQRQWHVGWQGEDDPSWETDQTMSPFPAWPTLRDSYKPQRGKRESRARSQWLGWEVRCRSPSPVDFTPRTLSSRTRSGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAA4</accession>
    <name>K1VAA4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAA4"/>
    <dbReference type="HOGENOM" id="CLU_1483014_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAA4"/>
    <dbReference type="OrthoDB" id="10522598at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="182" mass="20084" checksum="EEF8E27B7634E7B5" modified="2012-11-28" version="1">MATIEASRLFPTADKEQDSAIASSPENEGGFRNFVRRVSHSFTQKADPAAVEQLVQMGFPRGLSERQLNACNGNVKQAAEYMVHAAHPPGPKEDRWNHPDCPICVREANNVRIANARAPSLGNVLERIRSRDSSGKEHEPTHERRGSVGAMLRRPSISAALARMTSRDVQHPTNPDHISPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAM2</accession>
    <name>K1VAM2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAM2"/>
    <dbReference type="STRING" id="1220162.K1VAM2"/>
    <dbReference type="eggNOG" id="ENOG502S92G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073399_1_0_1"/>
    <dbReference type="InParanoid" id="K1VAM2"/>
    <dbReference type="OMA" id="DVWIEVK"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24228" checksum="EDE7172C816F1404" modified="2012-11-28" version="1">MLLPAGFALPTSGEPVLISDTTAASSNFALYHLIQLAQERAVPTTLVDLRQEGAASHTAVLRKLGIKPPSFLSPSPLPSASTPLFTSSGPSLHATFAALPKSGLVILDGLSELESIGFSALDISRFVRAVRDSGVLLAFTLRADLTGEEDKDVEQPELLRRLLRVSGQWWRIQGLQSGRSADVTGEISRHKLNGQGEDVGRQNPLQYRLEIAGVKTFAKGTGRGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB26</accession>
    <name>K1VB26_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB26"/>
    <dbReference type="STRING" id="1220162.K1VB26"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_1"/>
    <dbReference type="InParanoid" id="K1VB26"/>
    <dbReference type="OMA" id="DFRHEEP"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005485">
        <property type="entry name" value="PRK07092.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF133">
        <property type="entry name" value="BENZOYLFORMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="8">
        <location>
            <begin position="195"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="9">
        <location>
            <begin position="385"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="523" mass="56035" checksum="E8535A8D3C5E48C3" modified="2012-11-28" version="1">MTTKELTVLDRTYEILRAHGLTTIFGNPGSNELPFLASLPDDFSYVLGLQEAVVTGMAEGYSRATGQPALVSLHAASGTGNAMGALTNAVYAHVPLVLLAGQQVRRTVGQEVMLANVDAGMLTKPLVKWAGEPLAAEDVPRAMSQAILEAITQRGPTYLSVPWDDWAHMALESDALLPSRRVKVCGALSREDKDELLQRIANWKRPVLVLGPDADGAQKSSVQLAERLGAAVWIAPSAPRCPYPTTHAHYRGLLPPGVESVRSRLEDYDGILIIGAPLMRYHRWEPAAYTNGQDVVHITQDNSEATRAPYGDSYVANVHQAIAALAADVPDRGERLERRSTPPAATSEKGMTGEQVLAVLDKHVGDSITYVNEATTLDVTFLERMRVSRENQYHFPASGGLGFGLPCAVGLALGRPDWTVVGVIGDGSANYALPALYAARTHNTRTIFVIVNNASYGALRKFAVALQAESSPGLDIPGIDFVSLAKGYGVPASTVSTPEELDKAYTDALEAQGPVLIDARVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB45</accession>
    <name>K1VB45_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB45"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="K1VB45"/>
    <dbReference type="OrthoDB" id="2581982at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="281"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="472" mass="49855" checksum="B40196D1AE1DDF4A" modified="2012-11-28" version="1">MKDSSGDTTPVTTVTEKDAKDVAVLDYAEHAEPTLAVDENAVAAPVDPPETPPTALDIGPPPDGGTLAWMTVAGSFCATLATFGITNAYGVFQAYYAQNQLKGYSASTISWIGALQQFLLFFNGLLAGRLFDAFGCEAVFITGTVLCTFSLMMTSCKCVPVTKLTSVCTQYYQLMLSQGLLFGLGSSLIFTPAVAAPSHWFARKRALATSLGMTGSGIGGAVWPIAINRMIDAIGFGWAIRTCGFIVLFLLCLATLLIHRRLPRKRFQPLTHVWHQFSDTNFAIFTLGIGLSGLGMFTPFFYLTTNALRLGAAPTLAASMISFLNAGSTLGRLGAFVGDFAGHLNMMVLGDVGIMLTLFAMWVPLNSVSVLIAFSVLYGMLAGFVISLCPTCVAHISPPTEIGARVGLMYAAVALFALAGPPINGALISNKGGGREGYRDSGLFSGAAVALSLSCVVLARMRIAKGKLRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBB2</accession>
    <name>K1VBB2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBB2"/>
    <dbReference type="HOGENOM" id="CLU_1442027_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBB2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="188" mass="21051" checksum="BAC9E5BA9FB61DF4" modified="2012-11-28" version="1">MELPITDALANHPYFRQCLALTESRENKSVAGPDVLVEAGELMEAVDKDSNATAQQKRDAKALLNFVAPNKNWDEDTVSKYFQTAILRYYDRRTSDQKSFEEAIIRFTEMVGRQHPSTSAVAGAMGAGARAAAATVKNETPEEAEKRKAKNKKKALQKKNKAKERKELGLPPKVKEPREDPKLYDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCA4</accession>
    <name>K1VCA4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCA4"/>
    <dbReference type="STRING" id="1220162.K1VCA4"/>
    <dbReference type="eggNOG" id="ENOG502RXXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_1_0_1"/>
    <dbReference type="InParanoid" id="K1VCA4"/>
    <dbReference type="OMA" id="GRRVNWA"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20216" checksum="B854A042EB7757A2" modified="2012-11-28" version="1">MPHADSSLVPEEIKTKQQFYEHVHEQLRALLSDSTFWVSNLAQASALLYHSYAGTSLYGLNGTSPVVNWVGFYIQQNGEGDLIVGPYQGRPACAVIKAKAGRGVCADAFVGDKGVVVTNVDEYPGHIACDGETKAEVVLPLRLKTPEGDKTVGVLDLDSTVLATFDEVDLNGLQTVVDILRETSHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCW7</accession>
    <name>K1VCW7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCW7"/>
    <dbReference type="HOGENOM" id="CLU_765455_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCW7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="363" mass="40953" checksum="8AFEFE8317DCED1A" modified="2012-11-28" version="1">MASARQKGKQRANTEPQQAPAQPRPITPTWNPRYVSFCPYNKKAHSPYPYEPALDSLQTSLKRKCIPDPDPIDTYHLMLLVLEDLRDYVRPLLYTDIPDDARHFARTQWGLLNLIQEFDSLPNRVTGEEREVEKIMAEFKPAIAYEGLVRTFALDVIRAGMKYFDLLAERGQAGVAIPSGSSSLQAVHSRNRNRTAGRVSTAAASSSAAPSPGRKLELELALKVFQTGADAAVQTFRFSFFLHFDNARAMWANRIRVYDHLMMVMWEVKRQILQPNEGEKGKESENVEKPEEYPDDEDGSSDSWENVWFREDEGEANADHDASGDPSSAAESSRDAEPKTQVKKKGKKIKNAKLLKARARMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD94</accession>
    <name>K1VD94_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AflYb/ hxtA/ putative hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD94"/>
    <dbReference type="HOGENOM" id="CLU_3015881_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD94"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="56" mass="6302" checksum="A1242AEBC16E9972" modified="2012-11-28" version="1">MIVIVTIVIYFYYPETQGHSLEEIAVIFDGPAAKTTADDDDDFVAPEERRGTLDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDD8</accession>
    <name>K1VDD8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDD8"/>
    <dbReference type="HOGENOM" id="CLU_723988_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDD8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43061" checksum="DEE2458EB9F38F63" modified="2012-11-28" version="1">MPDLSETDPRVQIDASYYPHIMDQILGLALPSSPLTLRKVCRYWRALVDVQEAHHVVLDMGLPPFEPEWPEVTEASEDAESDAGAAASVHDAQPDEDGDVPMPPSPPPPPMRLVRKPAQNVTYVWQFSAKRLPITYMHRTLAGTERRTLPWVDVRRNVRAIDIRSSAQWVRDAVPLDDFKLHTVRLSKGAGWDSVTMLPHAYRVVFANGPYARNLAAIPDNVQACTCERTHTRRVVLNVRNPVLDAIDERVPPTIPSGLRELVVIFHGWPVIPQYNPIDDADADGGLNGDPRNDARQFIVAAAAAGVRVTVVNVELLDLKKGIKTCNWESYQEELEEFCAMDVEEMGMDPEQVMQRVRFVSAEKYRKRVGEKEFRFEAMLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE34</accession>
    <name>K1VE34_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE34"/>
    <dbReference type="STRING" id="1220162.K1VE34"/>
    <dbReference type="eggNOG" id="ENOG502RSB3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336221_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE34"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="162"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="162"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="803"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="843" mass="90423" checksum="059C25377C25E6F6" modified="2012-11-28" version="1">MPPATRPILAHRPHTYPHPSSSSTQAATLSSSESSSSLPPAPVIDPSLLAAPIPPPLVNGGINLAMVAPAYSPQVTSSSSAGDHRENDQDYFGPIAGSSAAGPSNQYKDDKAPIQQWDGFTVPPPATLPDWQQQPPTAGEPSRPTQDPDAPYDLARKKDGKIARPPNAWILYRSEMLKHLSEGKPVEGLEAALEELDNPTEDPKDGKKSKKSNKKAPAKGSQELIGQLGGGKGGRGLPQAEISRVISVLWKREDPERRRHYENLAAQAKEEHKKLYPGYKFQPMRKDEKAAHKAARQRERDVCRRTKAGDKAATKITRRRNSRHKRSPSNEFGSTHMDRTDSCSSLSSEQGGYFHGVPFDTLGPHPFPQALGGFAVDIPASIAGRGLLGCNADASTLEFLSAADVLADGYAPYMPAAQPHSTPLMGHLMSTQFPSSSRSGSIALSLPGTSSSPEHHHDFGVERSVPMFASQSDMSYDTLQQSIEFNDAHPMMGYSTMANGYGNSAYVPGRPLPYGQPITAGGRLNHNIPAATPYQFTPMKVPTEYLSHVQGTNEYTDDTITDLAAVWCDIEEPPVPSPAPAATVIPATIGGQTGQTWAEHQRVESANMPRIPMAPPGAGPEAGYSVPQFVNQYENGSGGVMTPQPGHLEVPRMAASVHSSPLSQPIFFDPSKQTQNGVKAEHTPSPSMQHAMTQRAQGGDTLGQGLMPSPVDQSFPQNVILRPVQQGPVASPQPASTYYDANSPSNMLVPRHFSNSIFPLSPTGTQLPSWAQDRSFSSSSQQAQIMPSMSMTPGQLLGDDWEDVPKPPANLASPVPLSQSAPAGTMMQPSQRRVVTGYENPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEJ2</accession>
    <name>K1VEJ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative zinc-binding alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000283">
        <property type="protein sequence ID" value="EKD02435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEJ2"/>
    <dbReference type="STRING" id="1220162.K1VEJ2"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="InParanoid" id="K1VEJ2"/>
    <dbReference type="OMA" id="AMGHEMS"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF26">
        <property type="entry name" value="GALACTITOL 1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="64"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="405" mass="43333" checksum="43C498329D6AB1F1" modified="2012-11-28" version="1">MLSRLSQLAPISRRVPTYLAPISRATTASPSVARSPARPARSHATMTNDTLAADGKMQAARYYGRGDIRVERVPVPQVKPGTVAIDVAYCGICGSDLHEYLDGPIFCPIHRHPWSKEQIPVTMGHEFSGRVAEVGEGVTDLAVGDNVCVEPYILDPAVDTSPANNTYHLSKGMGFIGLSGGGGGLSERIVVPRRWVHPVGDIKLNEAALIEPLCVAHHAFRRSGAQPGDTALITGAGPIGLLTAAICKAKGVRAVMSEPSELRRKKALETGVAEAVFDPRQVDVAAELQKTGGADVGFECTSVQVAFDTLVDALKPAGTIVIVSIWGHKAQLDMQKIVLKELSLKGTIAYANDHPEVIRLVQEGKIDLKPFITKVIGLNELVTDGFDTLINRNDTAVKILVDPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGE5</accession>
    <name>K1VGE5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000356">
        <property type="protein sequence ID" value="EKC99905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGE5"/>
    <dbReference type="FunCoup" id="K1VGE5">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGE5"/>
    <dbReference type="eggNOG" id="KOG4186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049216_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGE5"/>
    <dbReference type="OMA" id="AYHPTVA"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29533" checksum="8D9D97BE01BDD405" modified="2012-11-28" version="1">MTIAQKVLYSPQISTFLAVLATTIGRDKTYRLIQYISRILAWSYGRRGLVEAAARFNALKGGLGMGRKMMRIFKPLENLRSALNISEQPLAGIPRTQRIAQTTQFARQLCYAVFLSTDTLVWLQSIKFLQFDKEKAAKVSRISNKAWISGLTLSIISSLASLANLRAQARRFAVRADAGRAASSEKAPEDAAADEAERRKQGRALLAQRQQIMSQLIGDSLDIFIPANNLGYTHMSEGFVGLCGTITSYMALQKVWAKQAAGVRAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGU5</accession>
    <name>K1VGU5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGU5"/>
    <dbReference type="HOGENOM" id="CLU_1817162_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGU5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="142" mass="15092" checksum="FFE90CDA455BCBCB" modified="2012-11-28" version="1">MPTFVRQLLQLHPVFTLSLGFDTRHQHPLNQTPQLLSVLLAVSGPAVSSSVSVSLIFNQPSASHRSNSATLPRVLLAVSEPAIWILAASDPIVPNPAVLRASLVGALLQSLRSRRLAHPPPVPTLFEGLVPITPPPNAKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHV7</accession>
    <name>K1VHV7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHV7"/>
    <dbReference type="STRING" id="1220162.K1VHV7"/>
    <dbReference type="eggNOG" id="ENOG502T6IS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371801_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHV7"/>
    <dbReference type="OrthoDB" id="2623028at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="474"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="712"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="748" mass="81054" checksum="955A09A5AA1B8E8C" modified="2012-11-28" version="1">METSLWKLGNPLLAVSPWHSKTWFLALAPLGHGAQVASMIGLLIASTQLETLDERGRVQKQIAVAPSYVRYCAINIVRLSIHVLLESWLVYRHSRRYRPQPWLLANAEEEGVQPEVGDGVDMALEYLRPREEVGRVPTPHPDPSPSYTVPPRTGETESTSGGDGREKVDEVAVKSMEGQFEKLDQLEVRIDQLEEMLGKMEKKPKSREEAKEEEKVEDDKSSSSAPASSSSTNAVPVLNTSSADSASLPRATTSSSTSSSPLSRSRRARCLAARSDSPKDSDAATAEQILADPPAQIAAFIPSAAAEAAKRRAERLQRYDSAASNADLWVCCWGFIMWVVGMIVAFPPEPARSRAPLVFAATMVSMASNWFTALGFTACFLLWSLGYIIVLVAWLLWHLGIIRGAQPVLFPRASAMKLPKEELDKCPLVIYCADPEEETPEWEDLPGRPLALGEIDREKLPHPLRVLGVNKATCGICHTEFLPPCIVEEQEAYEVEVLRELPCLHTFHRECVDEWLLNHADTCPYCTQSVPAMLKDPGKAKAAEQAEARGEESGELAELRRTMSRRRSQRSIRTIRSDRSAVSIASARSNTSTSAKGAVRSIEASSDPADASASGSSSSSSSSSGSSSSSGSLRPGQGVAERKEKTDTASISSEDSASTQQFHDSREASTPTPVPASPASHSMSRNASLSTAYETAASSLALASMRTATPSTPIDVAWSDTPARVDTPGTPGTPGMLEAKKNENVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIQ3</accession>
    <name>K1VIQ3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIQ3"/>
    <dbReference type="STRING" id="1220162.K1VIQ3"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009770_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIQ3"/>
    <dbReference type="OMA" id="CEHAVNP"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="511"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="639" mass="67329" checksum="5E54111F6744A095" modified="2012-11-28" version="1">MNPFARVLDADLAKLDDRHRLTLRSTLPTTTGLTPMAPRSAQAGPSRSQKSAAQAPPPSPSVSGFNPSRTHFALALPVLGSADKVQVWDVAADAVVAEWEVPGAAQVSALCWASVASSGAAKKRRRRKSLPGDGGDEDVLLIATNKGTTSNLLSYIPLKGEVIRSSPLPGKATAAWSDEHGVIVATDDELLVLGPDASSISNTFDLPSSSNSPSAVAILPTSTPEVLHVIVGTMSVTAVHLSLSSSSVSHTSSPIPASTTAITSLQPLPLSQQGASFLVVSEGDRTVSQYTFPSPTATAKLSYRYASPTLSPAHSLAVSPELLSVLHFSGEISLFNLPSEVDFARPKSDSKPKVVKLVEGKEERTAHLVRAEFAPVEQGAPGALWCGRMAGGGRVKWYKAVFEQPEGGLRQTTVVKCDAQDLVNNTSAADGPSLQRFKAPANIIQAADEDESEPAAALPTDVDMADASLGERLLALPNGAQANGESQAALDGPVNAASLTRLLVQALHTSDPALLTLCLSHRDPVLIRNTVRKLPSQMALPLLKACVERLGQGKGANRRGGGRGNMQNEQQGRGTVEWVKGVLVERGNILMTLPSLPQQLSQLQRILDQRIELYQPLLSLSGKLDLALSQINSSSVAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK29</accession>
    <name>K1VK29_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK29"/>
    <dbReference type="HOGENOM" id="CLU_963739_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK29"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="289" mass="32943" checksum="2BA3F6C4A87179AC" modified="2012-11-28" version="1">MFCTELAAEQFPFPAPAGTRFCEKEVPSHSETTPLYTTEPDGRPEVLVAECVFTGCKSWMSFLPGCSDMHKQCVYVSFQYLEFDFAFREAVCTRNDLISAFNTLLSDRKALEDALIATRMVLSGLEVMPGTQQASKAKILHEKNAQIHFRERLRILRCQCEEAFRRLDNGIHNFGQYLYFLSLCEDYGIPQLGWSCWGGWLSEENVRFPEKREHMFRNGWMCDDYAFRAAKVINASEAPEEVKQLHVDLDGLTREYLAFKGYALTPTAAVMHRPPTPHGADDLPPPYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKD0</accession>
    <name>K1VKD0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_01080</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKD0"/>
    <dbReference type="FunCoup" id="K1VKD0">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKD0"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="InParanoid" id="K1VKD0"/>
    <dbReference type="OMA" id="CYRSWVR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853862" description="RNA helicase" evidence="15">
        <location>
            <begin position="30"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="331"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="549"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="171"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD04620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="705" mass="76844" checksum="AE17E0A4B9A9D89C" modified="2012-11-28" version="1">MPHRPSPTPPSQISFTAFQFHFLFLLSSSTPPLPPLLHPSSQKHRETSSFGSYSTLLHWLSIHDTTCTLFSLCTTTIDREDSEEPTNFFPHPPTPKPNPSTRPLVAPIHGRDKPSLNPSGQVMTATVNDNTNGNAAGATGLENKFAGVSLNTNNATKSAYVPPYLRARQAQQAKAPFNGAAPTPAHASGNGYRPSPTGLPTPAPTPVQNSGAYHPPRGGNDGGWGPRGGGRGGDRFERGTAPGAGAWRDGKHITGARNQRLEKELYGEEGDGTHQSTGINFDKYADIPVEATGSGVPEPVTEFKAPIDPVLLENIQYARYTTPTPVQKYSIPIVALGRDLMACAQTGSGKTGGFLFPILSAMYTYGPSAPPPDNNSYGYSRRKAYPTALVLAPTRELVSQIHEEARKFAYRSWVRPAVVYGGADIGQQIRQLDRGCDLLSATPGRLVDLIERGRISLANVKYLVLDEADRMLDMGFEPQIRRIVEGEDMPDVQNRQTLMFSATFPKEIQMLARSFLKDYIFLSVGRVGSTSENITQRIEYVDEHDKRSLLLDLLLAEQSGGLILVFVETKRMADSLCDFLCSQQHNATSIHGDRTQREREAALYAFRTGRAPILVATAVAARGLDIPNVTHVILYDLPTDVAEYTHRIGRTGRAGNTGTSTAFFNRSNLAIGRDLIDLLKEANQEKIWVLSLLSEVGTDAAVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL72</accession>
    <name>K1VL72_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metabolism-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL72"/>
    <dbReference type="STRING" id="1220162.K1VL72"/>
    <dbReference type="eggNOG" id="ENOG502S5QH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL72"/>
    <dbReference type="OMA" id="ICAHAAP"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="290" mass="32294" checksum="27BB7289C5EC36A6" modified="2012-11-28" version="1">MSAKGRAYLTARANWQPDGWQKAPTDLIRDHPLAAHGLNQSDDLAVFLTTPREYPVPEKIVASPWYRCVQTAAPLALKLKKQIHLDHGPAEWYSHAAPETGLHPRPIEEGAASMSKHFPPGLINEEYTSTVYPSRRGESLREVHDRLDLFAKTFVRRMDEEGVRSVVIFAHAATVIALGRALTGDPKREVTAACACTSLYKRIGMGDHFEQIWNGRTDYLPLGLERDWSVGLPLISTHADEQFDAVELENGEVVDDEGDMEEHSPEDELPVGLGPGMEKFAPKTRVVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLT2</accession>
    <name>K1VLT2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLT2"/>
    <dbReference type="STRING" id="1220162.K1VLT2"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256368_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLT2"/>
    <dbReference type="OMA" id="YFAPFID"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="468"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="684"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="906"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1152"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1170"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131170" checksum="C5A4FD386568AD26" modified="2012-11-28" version="1">MRRSSQLHSPSTVNSPTTSPNRVSSPVSVFSATTTSTHPPPSANYPPSHLAPPTPAITPPPVLQQPPPSRLSPYLDKIKALIDKYKREPWFFSCILVGVGVIVKMLGFKGTVVALLMIASGLFARFILPPPHNHVRVAEPHPPPGAMADSVNHALRALFPLISTDVLTPFVDLLEDALIQQVPPVVTSVRLTSLSLGREPILLTSMRPITDDEWFRGLAQQPKKKKGEPDDLEPGTYVVHSAYKPPPSDDQATPKKSRHSRSHSSASKASIMSRRSTAQNSTADFELTDAAAAEKEQMRKRDKLKRRLRKIRAKHDAQANGEVYVDDLDDEDDDDEDIDEDAGQYVNYEVGFVYRRTQRTTGRGNAIHALAYFGWGVKGLGGSEIPVYIDVGELKGTVRVRVLLSASPPFARTATFSFVKMPEFDISARPLRAGSFNAMDIPLIKSYVMKSVAQVAGAFVAPKSYTMDIDRLLLGHEAMTRTLSVGVLHVAIHSAQDLPKVDSLGSCDAYVTASYSKFNKPLFSTRTIVNSANPIWEEHAFLLVNEETIESGEKLRLRVCDSDRFSADDALGIIEVDVAEIVDQSTRASGEQLFYRRSDLQPEHPGMRVQGSVDWSVRFFPLHKISQQELERRIEENKDKRGEGSTPAPWWLEWLDKWCERPEWEKEREVRRKEMVQYFSGERVREEIEAAGKPGPNHPSGILQFHIHQAVDLELASVSGTFSGTGGKHRSAASGKPALGDAIDRAPWENPDPPNPYVEVHLNDKYVYRTRTKQVNPMPYFNAMSERFIRDWRLAKIVFVIKDERDREHDPIIGIVSLPLKDILKDGCQVTRWFPIVGGLGWGMLRISLLFKPLEMHLPEGASSYDAATFDLLSLSASDLAPIVGKPPHLLVETEYDRVVLDPPGGVLADDSDDDTPPTTDATGSLMSAPGPTGGIDVNYPITSPIRLAVRYRTSCSILFSFHTRGRLRKAKIFAIGTMRLINTPDNEKTERIIPVFLTKSTRAAFRAARIYEEYTQAAQSGSSNLPSIGDAKLIGFIKISFVLHPGVSRAHRKLAKRDPKFKSVYKAWEATRLLESAAARSNDSDSDYDTAASDEEDVVGQRAADKMVEDDSEAMLAGNAHGKALHQQNRGIFQLKLARTGKFVKDKLENKVKNSRVAGHGGNLAGRPHGHDVEVEHEGQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM05</accession>
    <name>K1VM05_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM05"/>
    <dbReference type="STRING" id="1220162.K1VM05"/>
    <dbReference type="eggNOG" id="KOG1689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068704_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM05"/>
    <dbReference type="OMA" id="NDEWEIG"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26748" checksum="8F5C9B8354F56352" modified="2012-11-28" version="1">MTIELKDPADTVAPQPIDLHPVQNYTFLNTSVQPEEDSSVAERMRRLQDQYDETGMRRSVDAVIVCHDHGVPCIFTFQIANDFFKLPGGYLDPSEDDVEGISRLLEEFLGTGSKQWRSDQPNWTVRSLLAVWYRPNFDGFFPAHVSMPKECRKIFLVTMAPEQMLGVPLNMKLLAIPIHEFYDNTQRYGPQLSAIPHLLSRRGQCGDKGTSTVASTVRPIVPAYAVDQVVRGPSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM98</accession>
    <name>K1VM98_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fork head-like protein XFD-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM98"/>
    <dbReference type="STRING" id="1220162.K1VM98"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399117_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM98"/>
    <dbReference type="OMA" id="QRDANTH"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="190"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="190"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="690" mass="74938" checksum="557AA30787831091" modified="2012-11-28" version="1">MAPDIPQLPAGQSYAGVNYLSLQQPSQLHSAPMVAGDVFTSNTGSTMLLNTPNGFDYALHELQPFATPNGESTPTHGPHKPSIMPSSASSSVDDSSSAERPRRKMIADTSDDEDNDSPTKRVRDRIPTFDSAQQGEPRALGARKIQLTVNRPPRTLAKPGAGGRTSAKFTKVAEDPGVEGIPPGPRSTERPSQSFACIIGQAILKSSAGGLSLEHIYRYVETAYPYFKTVDQWRNSVRHNLSIHKIFVTIPRTEKHPPGKGGIWVIDDDEKIHWPSEDKFIKTFPVSHPHHAVCRQTLHEQATEKRNREKAAAEGRVYVPKHKGKKGRAKALKSELASTALPLPPPPPVPQMAFAQQSQVSLAQQPQARMAAALLPSSPPRSADRQSLDFEDDSDFVPVAPRKQRGAELGPPAPLPPPRFTIASARTASSDRDDDENVFSSGPKRVRLSQAEPLSPIMEQQPMTSSFLHDDDDMFLTPARERPQSSNLPSSSRHFTSSAMKTPALVQTSSSPTSSPLPPTITRSSHHPSSLQQAWTQDDMARGSLASSPPIKQLDAAFDLKPMPTKRDRDREDEGLTLSLAPHVERAHPKTPVTRSSAAADRTPRLGGYRTPGLIHKTPLSYGSPARAPPSASALLSTPMWEISGVLERMNAAESPTRTPRTDVPPTSPTHYSLSDCGDSPVAKRRKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMJ4</accession>
    <name>K1VMJ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMJ4"/>
    <dbReference type="HOGENOM" id="CLU_2759601_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMJ4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="70" mass="7814" checksum="3CC5E5A978D166F3" modified="2012-11-28" version="1">MHPNQLNVLSIRPRLQYNQNRTPPEPTSPDPRVRDSLDPCPSPSSVPYSPEPSSHDPQSRSICMLGRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VML6</accession>
    <name>K1VML6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VML6"/>
    <dbReference type="STRING" id="1220162.K1VML6"/>
    <dbReference type="HOGENOM" id="CLU_041051_0_0_1"/>
    <dbReference type="InParanoid" id="K1VML6"/>
    <dbReference type="OrthoDB" id="10658735at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="409" mass="47121" checksum="A85A498580A7519A" modified="2012-11-28" version="1">MLALLPTGTACEKLDALETEFAVETVPEYRKRWGVYAMKLETLEFFDPDDYDNHTLRRVDAQLRAAVDQYQARHLVLIPEGLYSLKVTGPEGKIAAFMERPQFWKDQRLLDLLPYTRVVDVRGFCPPTIDLPHLATGFRNLEVVRMSPDDTGASTPYVPWPARTLVLFASFAGFWVNDRHWWWDKETKLDPNWEAKNLTVPHGRRPMVPPGVDQYALFDTFERIVLNFNGDLSSLEEILPLFRNLPRTVKEVLLVLPRNKSLDDSGTLFSFYAGLEMSFHALTRAQHAKYTFVGFDLAKPGYNDELRDKLRQWKKTELFIDVDYGISCADTADLRKRERYVAASEQARANGVLEGKPVEVPTQLVDLTTKVDQLMADMEFITQAQYRKCVDSEVASLETLEFFREDEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VML7</accession>
    <name>K1VML7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VML7"/>
    <dbReference type="FunCoup" id="K1VML7">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VML7"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_1_3_1"/>
    <dbReference type="InParanoid" id="K1VML7"/>
    <dbReference type="OMA" id="KQARGMT"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="247" mass="26494" checksum="257BB4105C36E948" modified="2012-11-28" version="1">MGNNKFIVFGGGGHVGQAFARQAIAMGAEVTSVVRDDSHNKELDAIGAKPYILSLEDCTVDDIEHLVTSISPRAVIFSAGAGGKGAPERTRAVDLEGLKKVAQALQKTPCKRLLIVSAIDVRDRTQGYPAHYNEDSKKGSDEVWSRIGRYMQAKYEADAYLHQSGLDFTILRPGRLTHEPAGGCDLGLTQMGHTSRALVGEVLLACALTDGTIGLTLDVLDGTKSVKEEVDRCARLKVDAWGKTGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMX9</accession>
    <name>K1VMX9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMX9"/>
    <dbReference type="STRING" id="1220162.K1VMX9"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="K1VMX9"/>
    <dbReference type="OMA" id="KERRWHI"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="476" mass="52486" checksum="0749B9B40C4F89D0" modified="2012-11-28" version="1">MVDVLDVKYDPEAAINEEEIKKCDISHKETASVAPYIYVPNTPEEAKLIRKIDAHLFPMLWLMFLMNYLDRTNIGNAKVGGMEKDLKLSSSDYSLVLSIFFVGYLLWEVPSNMMLTRSTPRIFIPTLMLVWGAISIAVVGVHNLGGMVAFRFVLGLVEAGFFPGIMLVISCWYKPQEMAKRVAILYSSTMMAGAFGGLLAGGIIEGLEGVRGIRGWRWLFIIEGIMTCVIALAAYFVLPNYPQTTKWLSQDEKRLALARLLAADSDVDVDAEVEHMGHWDAFKLAVKDPKTWVFLVIYNCLSSVGTISYFFPSLLETMGYSGRTLQFMTVPIYAVSMFVGCSAGFFADRTGMKAYTICGGAVLSVISFIICVTVGEPKVRYAFICFGAAGIWTNIPIFLSWMATMFDGKEKRAISIALVNGFGNLASVYGSFFWPKSSAPQFVPGFAVTTALCGFGGIICALAKWKYGDKGVERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMY7</accession>
    <name>K1VMY7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMY7"/>
    <dbReference type="FunCoup" id="K1VMY7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMY7"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_3_1"/>
    <dbReference type="InParanoid" id="K1VMY7"/>
    <dbReference type="OMA" id="GPNCQLY"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="25911" checksum="7A153C9D3F0B5C74" modified="2012-11-28" version="1">MATGISTPITGTSTPARKISHPLHDQPLAEPQVTPAKEDDTSALEAMRAGKPYIAGDAYLDKLRNHALALLQKGNMELDMGRRMAMWNGFLDLRYQDRKRIFIAAPFLCEYGFNVSIGDDVFIGPNATFLDVCPIRIGNRTMIGANAQFYTPQHPIMPEERDGLDGAEWASPITIGDDVWVGGGVIILGGVTIGDGCTIGAGSVVTKDVPPRSVVVGNPGRVVKTLPLPEKKDEKKEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNA9</accession>
    <name>K1VNA9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000397">
        <property type="protein sequence ID" value="EKC98132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNA9"/>
    <dbReference type="HOGENOM" id="CLU_940692_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNA9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="32341" checksum="67488AB92E9350F4" modified="2012-11-28" version="1">MASLLDVLLTPPFSQLAATALCSQTSARSARLGVEGRDDGGNASPPPTAVQGLPPLLVDNLAHRVPEPGIGIRGGAEADDVLVRAGEAEALWRISVGVLDADLPALVGLDRELGDDDVDGGDPRSTQRLEERKGEEAAEGRRAQVVAGQQAAHHDHERETGAAQRHARHHARRREEAHGVLQLVRREEDAERLAHIRWKAVRRDDRAVHDDARRHVDDAQDQRTDQDREAARHLDVLRVRLLAPDQAAADEQDRDGRVVHVDRQLTLVQTVPSLQALRAEERVVDADKARSDAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNB1</accession>
    <name>K1VNB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nicotinamide mononucleotide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNB1"/>
    <dbReference type="STRING" id="1220162.K1VNB1"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="K1VNB1"/>
    <dbReference type="OMA" id="LINAVCN"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="495" mass="53950" checksum="A8561C2EC703DB9D" modified="2012-11-28" version="1">MSDEKESIHRDSLSVSKGPALEVDDQFAVRLPESLANLTEAEREAVAKSGTRKVDIMLIPGHLSSAKVAGLAADLGLTTQQYNTCVSVLFAGYVALQIPSNMIVGKITRPGIYICCNAALWGVVSACTGAVQSYEGLAVCRVMLGVVEAAFFPGAIFLVSLFYPRRQMALRAAAFYTGSQVGNAFGGLFAIGILKLDGKHGLEGWRWLFIVEGAMTFGVAVICAFILPNRPDTVRWLTPVERDMLMWRLEVDRGTKDENDTVPIGRALKMALADVSPSHLFSLTSQPKTWLLCLTLQFAFIAATVTNFFPIVSEGLGFDRTTTLAITAPPYIICAIGLLIDGFSSDRFKNRSYHIVVPMCFTLVGNIIAVSTTAIAPRYFAMCLLPVGFYCASTIILSWVGDNLTGPSSKRAIVYAILNAFAQIPNIWSSYLYYSPPRFVTAFIVDLAASAAAIAMAFVTRWYLKRENRKMDEGEDLGPSGPSEVQLEAGFRYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNG1</accession>
    <name>K1VNG1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flavin-adenine dinucleotide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNG1"/>
    <dbReference type="FunCoup" id="K1VNG1">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNG1"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="InParanoid" id="K1VNG1"/>
    <dbReference type="OMA" id="IVNPFWV"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="129"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="229" mass="25658" checksum="8E58CDBDB88F5E8F" modified="2012-11-28" version="1">MIKKQMQGGDPAYRTSAGQHLLAAAEASTITALMTNPIWVVKTRIFATPKNDPQAYSGLWNSLTRIYKTEGIRGLYRGSLLALVGVSNGSIQFATYEELKRRRVEAKRKRFAAIGRQWQPEDEKLTNTEYILTSGGSKFVAIALTYPYQVVRARIQNAAPSEGLTIPKVIRNTYQKEGLRAFYKGLGTNAIRILPGTCTTFVVYENLVWLFRKAAVAKQKRESVKEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNJ5</accession>
    <name>K1VNJ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNJ5"/>
    <dbReference type="HOGENOM" id="CLU_1180924_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNJ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="26395" checksum="5CB6D7CFD68D220E" modified="2012-11-28" version="1">MARGELKTSYPSPVPARVKHVVLLFQVQRPWLFSRTSLWFVLACTTPVLHDLRAWQTLSIVIQDGDASLPEHNASPSDFDFDPEQEEAYRDVARVADIVNSAFLAHSYVKAIMDPHRDAFTPYNSPQGSGSNTPPTPPEWQPGRDEQFRCQGFDPDLLPTRRQLASCLNVCGPWRNLTMWDHPINFAGRLAAFDPHVRFMTMTDLSRMIGSQMMPYVLDLGGDVVFAPILGPASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNN6</accession>
    <name>K1VNN6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chloride channel, nucleotide-sensitive, 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNN6"/>
    <dbReference type="STRING" id="1220162.K1VNN6"/>
    <dbReference type="eggNOG" id="KOG3238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077804_3_0_1"/>
    <dbReference type="InParanoid" id="K1VNN6"/>
    <dbReference type="OMA" id="ENAEGWQ"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25321" checksum="92237DD9733A6B8E" modified="2012-11-28" version="1">MLERTRTPPPSVSQLEHDDLTSVTPQNFSDIPPVLHWQGPAEVEMNVPSWTSWSKTTGTLFVTEHTIEGDAGQGWTLPYQDLTLHALTPAGATPAHIYCQVDDSPPANGAPAEEEEFMTLAEMRIYVAEDQLQPLFSALSRCSALHESLLPDGTPNNFFGLADDSEGDDEDEEEEQDGDDGEIGRAEDGEDEGQDPVEAFLDKVDWGNVPPPEGWNAAQFDDAEEPEADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNT1</accession>
    <name>K1VNT1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNT1"/>
    <dbReference type="FunCoup" id="K1VNT1">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNT1"/>
    <dbReference type="eggNOG" id="KOG0973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004372_3_0_1"/>
    <dbReference type="InParanoid" id="K1VNT1"/>
    <dbReference type="OMA" id="GHENCVA"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="14">
        <location>
            <begin position="63"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="13">
        <location>
            <begin position="611"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="421"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="864" mass="93840" checksum="AE24D61D1FA7EA4C" modified="2012-11-28" version="1">MRVIKPNWVEHAAGELIDDFQADVQARRRRRVPSTPSPCIPMGRDWRLVAKIWSTLPILDAEAAENEANHKLLCTMSAHTGPVLTVRWAHHGRYLASGSDDAVLLVWDLDPSGGGRVFGSEEVNVENWKALRRLVGHVADVVDCAWSRDDSMLASVGLDSKIIIWDGFTFGTWSPWMLANSTERIKTIDTHQGFVKGVTWDPVGNYLATQSDDKTVRIWNTETWQEVQVISKPFELSPHWSPDGAFIAASNAMNGPVFVAAVIEREGWQSNISFVGHQNTIQVAAFNPRLFFQKGETPSRVNASCMLALGADDYNISIWRNTMHKPLVVIRDVFMRQLLDLDWANDGLTLYGCSADGTICTIKFEEGEFPELAEADMTSKILDEYGYKSTRKRIAPSKPLSVSSSFTAPPPGATEHVNVIIPRKSNKPKGRRINLSGTMTGGASSSNGPPRPSMGGRAPLARPAASPPRSGAQDAFSRAAEEPLSFGSGSAATASMFAGMDDSRVGDKRKFGFEDDNRAAKGRTMGASRPMARIEEIRAPRVVLGGQASGSGGHVLPIPSVQSALRVQQTDGHGVLTAENASDDSGSNTVSLSINNQDVWTDFIPSPALAVVSTASFSAVASEDGSVRVYSAAGRHDARRGNVVVTPTSMAHLLDVASTSGGSPTTLQVMAASVCPNGCPVVITSEPAGWAFDSGVGAWTQVASPWWAGSPLNETRTRGGRAPAAGWILAEIEAKFPADPPQIRNKPKWWDEALSLGHYETRLNATRLLGSKDEYLHWLKQYAKYLGDENFRERAEELIADLMGPIYYLSGKPNWTPNVMAGLVKRDAAIGALQAMRHTSALGGFANEQLNILRRMQGSEQEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP85</accession>
    <name>K1VP85_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP85"/>
    <dbReference type="HOGENOM" id="CLU_067898_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP85"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32262" checksum="72F7B96C1C03DE69" modified="2012-11-28" version="1">MSDDLSLRLIPASVIWFGPLTPERSLVSRLFHRPDEAVVRDLMSRGATREEARRAAKAMKTPEGAAGYLAAHRELCDLTHPCESPDQCWEYHGKPRRSASVATPSASGYAAGSGVASGSRSRRQTTGGLEEKDEAVLYLASHGFSERTAASALAFCAGDRDAALSALEHTRHTRVVPECSHCIAHPPAQDLDAGPYAGANVPNAANAVTDEPAPPEQDADELPQYSSAREYNRERRREQREEERIEALIRQHHQRGKKNRENWGKTCPSSQIVAARARLMFNPRARWDDLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPK2</accession>
    <name>K1VPK2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPK2"/>
    <dbReference type="STRING" id="1220162.K1VPK2"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375607_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPK2"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="739" mass="82690" checksum="960618509B304845" modified="2012-11-28" version="1">MSTPGSEASPRPKGSPAYRKDNTLELKPQVQRVSQSDLAAEAEAKRRKVLRACDVCRRKKIRCEGPMNSQSNAKCANCQEYNLDCTYVEAAKRRGPPKGYIDTLEQRCARLERLVNQLNPAIDISETIGPMPDRDEFELSAYQETLRSLGVPPFPAMKNIAELAATPPNGVGGGHSSPRVLGPAPWKTYERDPHRPPEDEDEAREQARIAHAMVKLNIRDHDAFRFHGKASGAHLVRIVNELKYNEADATFFDRLTAVKRPEYWMVPEWEKVIATESVKPVDYSVWPDEDLAGRLIDGYFDHTNTHMPLLNRVIFQRQYQSGLWRTNAEFAKMCLLVFANGARYVDDERVYWPTEVATTPEGQDRLRNDRDGTLKYSAGWNYLRAVIKMGRSWLQGPSLLDLQTTVLVCLFMNGSAVPHLAWLVAGSGLRMAQEIGIHVRSTMLLTNPIDRALYNRAFWCLYHFDRLSCSAIGRSVAIQDSDFDADYPIPVDDEYWDTGDPEKDFRQPPGLTPDPAVTAFTHLLKLEEHLTKPFRLDEAAAMQAWDIRYGQRPPSMAPDTQQAVLPPGWIQSSGTSRQFNAPREPHDQGWPGCLRLQWRRAEWEGKTAQNVASLMNPNLGAPPTNAAGETIFPEFFDADNLHSMGFAVANFDMIAGNPGEQAPAPDFWTSLLRGAGPQGLGTFGGIGSNSLYAGLPSERERQQPWNFMPWLGHQGDVNMQAQAQANGQAGQGMGGQQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPR9</accession>
    <name>K1VPR9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="AMBO01000315">
        <property type="protein sequence ID" value="EKD01467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPR9"/>
    <dbReference type="STRING" id="1220162.K1VPR9"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="InParanoid" id="K1VPR9"/>
    <dbReference type="OMA" id="LYAGGWY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF91">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="278"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="720" mass="80506" checksum="0F29C2BAFDAB1CD7" modified="2012-11-28" version="1">MSKSASLSAATAGLSISGAGGPQAARSTQGYHPLDPLSKDEVRAATHAIKQYVDAQEKGEHRFWFKSIQLIDPPKAVLAPWLDRWHQGLPVQRLPRRAECLAGVKRPDSTSWYEFYVSLDGEAKVERAVQCPTDLHVPPDMAEMLAAEEALLKHPEFLAAIEKLGLPKHWKVVADGWIYGADDFERKNRYTPFMVYANTNGNPDSCHYSAPLPLVPVMSSDDFSLVRIDWTPIFGTGEKTFLDLKEPFPWHLYESNEYDPELLVASGTQLRQDLRPYRVIQPEGASFSLEGRVLRWQKWSMHIGFNYREGLVLSDIRYDGRKTFYRLSVSDMTVPYGDPRAPFHRKQAFDLGDVGAGLTANELKLGCDCLGEIHYLDFDHLDVKGDTQTLQGVVCIHEQDDGIGWKHTNYRTGRPAVTRSRILILQTILTVANYEYIFNWRFDQAAAVHLEIRATGILSTAAILPGELSPYGNVVSPGVLGTNHQHLFSIRIDPAIDGHNNTVVQEDSVPMPFDAKNPPENNKWGVGYTVEKTPITRSGGADAAPHKNRVFKIVNPNVKNPISGKPVGYKLVPAASQLMLAHPDSVQYARAEFGEHHVYVTKYKDGEYYAAGKYTNQSYGNAKGMRTYVGRDDKTDNEDIVVWHTLGLTHNPRVEDYPVMPVETHMISLKPFDFFGRSPAIDVPPSTQAFNQSTLFKVASEEIEDNAPVNEGKDKACCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ58</accession>
    <name>K1VQ58_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04118</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ58"/>
    <dbReference type="STRING" id="1220162.K1VQ58"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_0_1"/>
    <dbReference type="InParanoid" id="K1VQ58"/>
    <dbReference type="OMA" id="EMTKMRY"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF44">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113215" checksum="0B289C33D168D2E4" modified="2012-11-28" version="1">MYPFNHPYHAQGSSPTRPAQTPQPRTRSPYGGTSPNARGRSSPLEPREPHTQSRQSEWSTVPAVNYSSTYRSSPSPRASPRPQYHTQHSNLSASSFVDYYTGTPASAMDTSPLIRGPTSTNYNNQSYDAQRQGYDQYDNYGPPPPNPYDNHNHNSSPASPAYNHNQLAPVHSNDGSYYNNDLTSYYSGDHDDKSYSSHTALNSSNSHMDGSPKSFGVGEVVPTMSYSSPPPPSPNMGYSYPPAPSQLPATPGFSGTSHWQKVRNNMMARRVVKKIPLTNGNFVIDVPVPKEVIRHGHLGIGAEIGEMEKMRYTAATCDPDDFMRCKFNLRPYLYGRRTELFIVMTMYNETADLLLRTLNSVIKNIANLCGRDRSKVWGAGAWQKVVVCIVADGRNVVDHRVLKVLQVMGIYAEGVMQDTVAGKDVTAHIFEGTSQVMVSESESGEVGPAPAPVQYIFCLKEKNAKKLNSHRWFFNAFGSLLKPNVCVLLDVGTKPSGNSIYELYKVFQKHDNVGGACGEIIADKGPWGRYLLNPIVAGQNFEYKMSNILDKPFESIFGFIAVLPGAFSAYRYAAVCNHPDGTGPLASYFHGEMMNLPGAQAKIFERNMFLAEDRILAFEIVTKKKAKWRLQYVKSAKASTDVPAKVPEFISQRRRWLNGSMFASIHALAHFWKVWTSGHNFIRKFALMFLTLYNLVNLLFNIVSISSYYLAFYFLINSSVASPDTDPFFGAGEEIFQVVSKLYIAVLFVVLICSLGNRPQGSKWMYTICILFLAVCQGVMLYVAGWTVYQTVPHDAAGWRDVKGLFENETFRDLALALLATYGLYFISSLIYMEPWHMFTSFIQYLLLLPSYVNILLIYAFCNLHDVSWGTKGDNGSAKDLGQVKITTKNGEKVAEVKSTRQEDIEDLYRQAKAELRIPMEHVKEKRSQETKRADADRNFRTHVVLWFLGVNMIIILVLTSHTVTEWLNTKFNPNPEETNFNPYLVSASWAAELPSAARSVGQSASGLQGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQM9</accession>
    <name>K1VQM9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQM9"/>
    <dbReference type="STRING" id="1220162.K1VQM9"/>
    <dbReference type="eggNOG" id="KOG2992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046015_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQM9"/>
    <dbReference type="OMA" id="ENNSGME"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="323"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="401" mass="40874" checksum="A149C0CE58EA3663" modified="2012-11-28" version="1">MSAQNKDLDAAVLAYLISRGLTRSVKAFEKEASATQGTEGELERVWAKGTEGAKEDVEMKSSDSDSDSDSDSDSDSSSSSSSSSSSSSSKASSKSSSKSKETVEGIISVKDAAKIPLPESDSDSSSDSGSDSDDESSSSSDSSDSDSDSDSDDEESGSSGSSTLPPPKSDKEASSSSSSSSDSDSDSDSDSGDESDSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSDSDSSSDSDSSSESEEEEPKKAGIGAKRARSPSSSSSSASSDEPAKKRVKEASTSASSSSAPSSTSTPAFTPSGTSTPQGGKKPRGGQGQRFERIKQENVTFHDARLMDNSFDAHIRNGANPNDFGARASRDLIVTRGDGFRKEKNKKKRGSYGGGLITLESHSIKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQP1</accession>
    <name>K1VQP1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQP1"/>
    <dbReference type="FunCoup" id="K1VQP1">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQP1"/>
    <dbReference type="eggNOG" id="KOG1678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQP1"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="201" mass="23516" checksum="2F11B141FC2B6863" modified="2012-11-28" version="1">MGAYKYLTELYTKKQSDVLQFVSRVRCWEYRQLAVVHRASRPSRPDKARRLGYKAKQGYVIYRIRVRRGNRKKHAPKGATYGKPVRQGVNHLKPQRGLKALAEERVGRRCGNLRVLNSYWVNADGVYAYYEVILVDPSHKAIRRDPRINWIVNPVHKHREARGLTAEGRKNRGIGKGSKYNHTPVSATWRKHNTLSLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRH5</accession>
    <name>K1VRH5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sphingosine-1-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRH5"/>
    <dbReference type="STRING" id="1220162.K1VRH5"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019266_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRH5"/>
    <dbReference type="OMA" id="ADDCPCY"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="513" mass="56591" checksum="56CDAC614E7761F8" modified="2012-11-28" version="1">MAIELVDPAMTNGANGNGISNGVHANGKRAAGNGDLNEKQPLHDDLNPLPLRATATATNTIVQPTPVKAGSKDVEEGKRSPSPPPKIEAGRHPDAVYAESLAPWRDSFRRWCVRRLGPESERIARWQAKVRTPARDTFFFYSAIFGTRTRDLLASHPLTAAHTFFTAFLPVLFWLGYPVEGRITHHREYGFPSSHSTNAISIALFMGQMMWERREWFGMPTVLLGWAVLFLYYASVAGGLDVIGGTLLGIFCWVGQIAGKAILDWVETGSLWSIYLGFPLTLALIHFHPRTPDDCPCFEDAVAIISVIFGCTVGHLLEHYFPLPKGSGVWSLGIFWGLFFNLVKITVGLAAIVVWRLIAKPTCLRVFPVIFRAVSKALDTELPHRPFYAPATTYKGGADAPIRPVPSFGELAHVDSDVNLDVKASSRRSPSPLNVEDSVQMRHRHQKGADMATLKRRFDPVAGNSHRGRRASLRKRYDAEVLTKFVVYTGIGLVAGTVTPFVARELELAYGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRI6</accession>
    <name>K1VRI6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRI6"/>
    <dbReference type="STRING" id="1220162.K1VRI6"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040397_0_1_1"/>
    <dbReference type="InParanoid" id="K1VRI6"/>
    <dbReference type="OMA" id="FWWKPGK"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="357" mass="38373" checksum="47D1C5A8F962C219" modified="2012-11-28" version="1">MTHSPPPPKPAPPPAPAAPAAKHGPVTVHRDLRTYLPPILSRFLGYKQQPLRPLPFPPFSWLSKIPLKYEVWGLGLLASFVGIMLVELVMATAFADQDIILIVASFGASAVLIYGTIESPLAQPRHLLGGHVIAAILGVAITRLFRKASNYELHDTTHTGELRHIVWLNGALSMSVALTVMQITGTVHPPAGATALIASVQPAAVHMSWHFIYIVLISALLMLGWAMIINNVGRRRYPTYWLSGSTVFVKPPQKLDPEAGLTPSSAANGGPSEVSTAGSTVNGGVGGVQGGERLQRTTTDEVMMAAIEGRNDGMERMVRSLSREGPVESKDAAEMAAIEGRNDGMQRLVRSLSRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRL4</accession>
    <name>K1VRL4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRL4"/>
    <dbReference type="STRING" id="1220162.K1VRL4"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_6_2_1"/>
    <dbReference type="InParanoid" id="K1VRL4"/>
    <dbReference type="OMA" id="SWATDAH"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="52834" checksum="7ED9A2D9F71E47CF" modified="2012-11-28" version="1">MITATWLASSEKRLPSSPRLRHNVDNIDSTMSAEDFASLLAGVTSHIAARDASLSSLPTFPSPDEVAVAVAALPSSLPDTGLGTQASLSVIQQVLNGCTVGQAGPRYFGFVTGGVTPAAQLADMLLSSHDENVQVSLPTTAAVRTEQKALQLVSELLGLEGFEGRTITTGATASNVLGMACARDAVASPTSVLALHPHFSIVKACSLVGLGRKIVTVPPSPDNELAFDLEALKAQLKKDKNEGKGSIVVIGLGEVNTGGFPGNVPQVAELCKEYGAWLHVDAAFGGFAAAVPEVAHLTEGMCLADSITLDGHKWLNVPYDCGLFFTRKMKSLTDVLGPGEDAPAYLASNSETPSPLYVNIENSRRFRALPLLASLVSLGREGYVDSRQGLTSDIFRRNCAFARQVAEYLDRHPNYELLNRQEGNHIVPLNIVLFAEKQPQEQPLADRINNTRKVYVSGTAWRGQKAVRLAVSNWRTGDADLEIVKQVLDEVVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSP5</accession>
    <name>K1VSP5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">20 kDa protein having G-X-X-X-Q-X-W-motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSP5"/>
    <dbReference type="STRING" id="1220162.K1VSP5"/>
    <dbReference type="HOGENOM" id="CLU_095794_3_1_1"/>
    <dbReference type="InParanoid" id="K1VSP5"/>
    <dbReference type="OMA" id="WHCIDSI"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854009" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="173" mass="18448" checksum="51813F10E0F3680C" modified="2012-11-28" version="1">MLSLLAKLALLAVVATAASPPKPLPSGALTPKFVAQIHAAGSRRKCIHVAGNIENGTPLQVGDCVGGGFGNPPFEINGGLTEIRVAGSNYCVDVGNAPLNNGNQVKIWNCHGGYQQQFDYTRDGRIRVHGQNICLDVTDGKLENGNPIQIYSCGDLDNDNQWFPAENVVQPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSZ9</accession>
    <name>K1VSZ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSZ9"/>
    <dbReference type="HOGENOM" id="CLU_1611967_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSZ9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="17786" checksum="6D20A4D4D8E5945E" modified="2012-11-28" version="1">MRRLQRVITEMLAQNERFNAPMLPPPTPLSASSSLAGQHSLPQTQATASQHPGLSSPASTTSALRSPAPRALQRAAPQPLNLRHSWDTNSNWSPAPSSARSEDVPPSVRAIIRKLVVLKAEINDKLWDLRRNMTAEGVEAVQTATADGIAALIADLRVLSTQFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTP2</accession>
    <name>K1VTP2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTP2"/>
    <dbReference type="HOGENOM" id="CLU_1180923_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTP2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="23801" checksum="C02D9866A25219EF" modified="2012-11-28" version="1">MFYCRWDFCPHTFASTAALAEHVREHIAREQPVYVPPSARHLGPDGVWTVDDSWSLSMSVDSTGPSLSMPSTSAPGPSGSAVADVGDLSSSGVSGLSSDVASGLAPALAPGLQVGGGLGAGLGQANLGAALTGSGYGLGAAFFAPISSLGGFDDMPPPPPPEANDTMFADFLRSPSPRRAAQHQALAPQQMQSLSQASLHFSQQMQSTPADAAASQSSAAAVSPPTDGPPQTQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTX0</accession>
    <name>K1VTX0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000347">
        <property type="protein sequence ID" value="EKD00128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTX0"/>
    <dbReference type="HOGENOM" id="CLU_1750998_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTX0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="149" mass="16509" checksum="45A00C39F5438B51" modified="2012-11-28" version="1">MSIQSKRIFRDHQRRQTNGWSSRTRSKFHHPPPRVIQTGLGTVDYFRALFEGLIPHGVDRMSPDFVIGLLVLIFATVPPPSHVVAWTLPPPAKVHQLVESLLPRFHPAARPSSSNSPSSPILPSSPVSPDLVTQTAVVDSVLRALIFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU37</accession>
    <name>K1VU37_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU37"/>
    <dbReference type="HOGENOM" id="CLU_460923_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU37"/>
    <dbReference type="OMA" id="KHNSHES"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="596" mass="64891" checksum="3EB2D1B23C03D301" modified="2012-11-28" version="1">MPPPPAPMEEKLAVGKPREDIMSRWPVMTRRLGGKNSRGLPSWLFEDPSVEQQAQLEQIRVFGLDVVRERAQAQAAASQSGSGDRSQASHKSAESQQSQQQSLTPPLDDAGPIEPIEVHIPPVESQPPPTPPMSSSPAPQQTPMLARQPSPQHLTPLPRHRTLHHPDPSSDDEIAVRPLRQRQRPHDSSSGSETPAPDLPSLPPHHTSLPAQTPTAEEGEAGDTSESELSEYERSRRRAMKRRADPPLNPSQDSQSLSQSQDSREFDLARYELPLSMPVDMPVDTPSRPGTRSMPPLSRSSPISASERSERPNERLWDKAGERVGERRRRGYEVDDSMGPPPAQRPRTEEPSGPSGRWRELPFASEWGEMGPPSAQPRTPRTPVKSEFVSYPSQAISTPSAAPTAKQEPREASEPREPRESHGPQPAGPAPTPAESQAAVEDGAEAEAEGEGEAEVKAETTDESTSLPQGRFKHNSHESLAPRPSPRRVPVQMRAHPFVSVSVSGSVSVSGSVSVSGSGSGSGSGELDAEAESKPDLDADEPSIESIEESAGSERELLGGWKPNLAVRGLNADWVRKVTKAAEDVRDRRRVKREKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU83</accession>
    <name>K1VU83_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU83"/>
    <dbReference type="HOGENOM" id="CLU_1157089_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU83"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26381" checksum="7131189C844AC830" modified="2012-11-28" version="1">MPTSRETSSSDSSTVSDDPSTHNAQEMLSDLMQLPFADFHHSDSSSDSEYDPATDLFSVFSRHTLLVEVTRPRPIDNPEPMREKMEAVVRNLDGVEGWTALIPSRLVGSYWEESVGLPVPGKKLLENRAVARGKSGDKDVCRENDDAELPASISTPESETTSNSRAKGRISHLDPVDESQPGVTFTFEIKGLSIVIGIMLGRLLARWGENQMGDCILSWYSNACVVYESDGECEGRVSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVZ5</accession>
    <name>K1VVZ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVZ5"/>
    <dbReference type="STRING" id="1220162.K1VVZ5"/>
    <dbReference type="eggNOG" id="KOG4774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091047_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVZ5"/>
    <dbReference type="OMA" id="TEEAGWA"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="180" mass="20023" checksum="94D27EEAB29C8CDC" modified="2012-11-28" version="1">MDEDDFFGGPTQGGAQDPLADAEYARIEQKYSDAGYREGITDGKMSTLQAGFDQSFATCVPLSRRMGQMRGAANALLSLATQAKADEQLIAELRALISKLSTVKRDDVLPIDHERIEHEKEHQQDDNGFEFAQIEQRELESLEDMMGNMGQKRAEPAVRGEELLDALEKELTEVQAKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWX8</accession>
    <name>K1VWX8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1783-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWX8"/>
    <dbReference type="eggNOG" id="ENOG502RZQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082491_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWX8"/>
    <dbReference type="OMA" id="FGEPWID"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28824" checksum="C85F17E925DE3137" modified="2012-11-28" version="1">MITRLLLPSARLRVVRPYATVSFPSASGSLNAGSSEPPRRPPPRAPVEPTVFDGKAAPREIHLRPSMRGMPPSDRKPKARVVAPKKVEEGQSFTGPSRPRAVYTRPSRELPRVKNRIPLYVALAALGVGAWGLFVLYATNNERLSSSVVRQVTFQLRNSPDVQAILGDHIRLADNWWGFGEPWIDGGINLMQGRIDLKFRMHGDKGDGTVYFTSIRPQQSAPWRIVRYKLIADNGEQLRLEDKFTKNPSPEPASAPASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX51</accession>
    <name>K1VX51_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX51"/>
    <dbReference type="HOGENOM" id="CLU_110378_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX51"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="179" mass="19095" checksum="CC6EDEE7AE034FEF" modified="2012-11-28" version="1">MDPTRSPEASSGPRPHLVLNTRDLTPRQLPLPPLPISLKDAFHAFQPPPKPQPRLDTEPLNHSLTARPVSAPSSHSSGSGSGSSLVTPAHTPHTTPGHPSTGHSTGHSTGHSTAPTPGQYGVMGSQGGPGHGGQQYSAGQYYAPHYYYGYYDYSHYYYSYPHARERAASPPTPKPEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX80</accession>
    <name>K1VX80_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX80"/>
    <dbReference type="HOGENOM" id="CLU_619922_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX80"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="442" mass="46431" checksum="FD6DF8883F377E8D" modified="2012-11-28" version="1">MAANKDSSADWWKRHPEAYGSIAAVLGVILICCVYVLWRGPNRRLWWWKKNDPDMPEGIEGGNKKLHPSQETFYSEPGTIRTTSDKPMATTTPQDTFSRDGSAVLPIRKSSLFTIKQARKVAAAVNQNTPPVPTYRPTSSGPVSPNPRHTKDFRDSSIPAGPLPPGAAPPSPSGGARAPSRGSQSLNAPGQRSSSVPSRRSVTSPVSGISDFGAMPGSPSYQTYPPPLPSPPPAFAPMMTKTPPPGATSPPLRASATMPPPGAAAYPVGSSPPVSPHLSARPLSHQRVVSPSGSSVYSNGMLSPAPPSPQSSVSGHAASQRLSGQQLPYSHPQTLNALAGNTLSPHLATGTAASRHANRLSSRSAKSATSITPSPLAQSMTGKDLGQDDDVYASEFGAAIDSRRNQHRSVTYVPHPEQAARVPTTYPSSSPPRPLMRGGEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXC7</accession>
    <name>K1VXC7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXC7"/>
    <dbReference type="HOGENOM" id="CLU_1769397_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXC7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="147" mass="16456" checksum="CF92F3B616AA54B8" modified="2012-11-28" version="1">MPVFAMQRSISAHPEARNGVKEVVFVYLPEDELKPPRHHYLEAAVPVAREALKLGARVTLVRPSDEAAGPQDYVKNGLTHEEQFLKGLLGSSWLGHPPGGDEESDNDDDPERLTRKQASDFRIISEEEYAMEVGQEAFKLETWWGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXU4</accession>
    <name>K1VXU4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXU4"/>
    <dbReference type="STRING" id="1220162.K1VXU4"/>
    <dbReference type="HOGENOM" id="CLU_689267_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXU4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="400" mass="42948" checksum="DCC5311DE5F55E83" modified="2012-11-28" version="1">MLPCASCRDLPCSHRLYPVPGINPALQVQIYRLQSCDSCTAIGSLCSNAEQLVYFDCSDTDCGIRSNADGGIRGGRMGGRGALRYLLHPSLNDERQRLEWEFTPTRVTLGECGSEKELPSLPSPRSSSIGGSSAYRRSLCVSPTALDTIFEDDEIDDPCKSELPTELETPVEDPTSGHHTEQPPPLEPSEENSYTKPSTPVDTKIPGSPPPSPPHTPKSLTPLSPVPRPPTPTSPLIPDSPRSPFPRPSIVPSVHPPGSPCSFISDTSDTSTSSDVAVTGHESHAGHSASSSSPPSSPPSPSPSPPHGGPARQGKLSRRMSGYSAEKLVPQPFHPHKSVAEVEAQIEGATRLGALIKAVEEWKQAAVRVKAGLETGDGNEVERFRMEALWQEIERCRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXZ4</accession>
    <name>K1VXZ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01276</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXZ4"/>
    <dbReference type="FunCoup" id="K1VXZ4">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXZ4"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_1_1_1"/>
    <dbReference type="InParanoid" id="K1VXZ4"/>
    <dbReference type="OMA" id="DSIHHQR"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="257"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="570" mass="60444" checksum="A59F5DC72812CB78" modified="2012-11-28" version="1">MPAQYGATDSQPQPPPPPSSTLTFSSPARDRDAERGRTMRQSYEGRAPRPSLERRRSRLETHQPGASVLSSVSNLANTIIGSGALAFPAAFASMGMVSGIVSCLFSASTATFGLWLLSRCALLVGQRPGDEGRMASFNEVARLAFGKGWVMRLFDLTTVRHRDQVLRRVGLVLDHLQDAAAASVRDVCAPAAHGAVAGELAALAAFLAPVHHPRHRPPVLHADARQSQDNVADCSVLRVLGPSPDRGEIVPFRFDSSTLASFPVQVFAFTCAQNLFPIYNELKDRSQAKMNTIITSSIFGAASVYEILGIVGYLTFGSKVSSNVIAMYPANSLVVAIGRLGIVFLVGLSYPLQALPCRSCIYLLQSGIIKGKKVPATIASARLVAGGAAEVGHETEGLNSSGNGTGGGHGEGWDQLPRRSTEGAPLLTQRGVDSPRGSTDEDLFSDDDSEMGNEEELLVPKVGDAGHGGAAAAEMPRKKFVGFTVLIVGLGYLIASLVDEMGTVLAFVGSTGSTIISFILPGFFYWRLYRGEPGVTKYLALALGIYGFAVMGFCLSMNIWALGRGKAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY28</accession>
    <name>K1VY28_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY28"/>
    <dbReference type="STRING" id="1220162.K1VY28"/>
    <dbReference type="eggNOG" id="ENOG502SJRQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059781_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY28"/>
    <dbReference type="OMA" id="TTCYLSQ"/>
    <dbReference type="OrthoDB" id="3356102at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852508" evidence="1">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="408" mass="43276" checksum="FD4F8376FB439F47" modified="2012-11-28" version="1">MLALSALVTLLPALASAATCVQFDSDKNLYAFGGEQDVAFGTADTWASPSPRTLQATGRPPFTGKNMQCMLSQNANALYVLGADESDQSAIYIYDFAGDAWSKQESSSPPEAIGNSRSSAILDHDTNVIFTLTPQGQLWQADMSSIKNVAGGSVPWENVRTPKWFKEGYKVTAAQAANHINYFGVPDTPDATAEVFVIHYAYFQNQTQLYPTQNNGVSFPNRAGQATNFMSPDDSAPFQMLYVPDDFSQTYVVTHWTNPGDYLNTTGAPMGAALINSTQLLPPPELKDVDAAYAASVSDVVQINNKGEIYYIQNAVTKYNVDSDAKWQKLNYEYKVAEEAKQKAENDSKADASSASAISSQTSASAAASASASQAAAAGNKDAGGAIGVQASVGLTLTALAAGLASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ35</accession>
    <name>K1VZ35_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ35"/>
    <dbReference type="STRING" id="1220162.K1VZ35"/>
    <dbReference type="eggNOG" id="ENOG502S56A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1065658_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ35"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="31493" checksum="36A10157B5D50344" modified="2012-11-28" version="1">MVQALAERAEDFILQSYKIRDVPLRLRPIKQEGVTGVSSSSSAFVTVVTVPIVISDSGRREEGKCLGSHRRLARNLDPDARRAGSSPIAGAAVERQGAAFLRGKLSIWSRADGQTDGVRELPDVFRARGAGRVWYIRRAPLLLTLFMAFFVGGVISEIVQGLLPTFQWGDIAANLLGATLFTYIAHLMSVRARRRSEIRELYQPLQASSYRDAQGRVHLFDRDVEAGEGGFSDDEAGGARGGVWDDTVSEHELRLSGDNTAAAFALGDEDEEDEPPRKKSPALGLQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZY0</accession>
    <name>K1VZY0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000145">
        <property type="protein sequence ID" value="EKD05102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZY0"/>
    <dbReference type="HOGENOM" id="CLU_1442030_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZY0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="188" mass="20685" checksum="7DBFCD95F79B54BF" modified="2012-11-28" version="1">MPDPAPPKRDRNIASLRLARATSIDTTGFPAPRRPASPTTSQAGSINELTRAVSHQPSAGPSTRRASTSKPNTSRRTERWVEAASEFELPDTPRRLTSGMRKSFAIDEGDDDESKEEMDEEDGVDRLGGRTVTFADEDTVELLPDDGMRLEEFERPRGREMFAIVTSCTVLAVLSLTAGFATVFDWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZY7</accession>
    <name>K1VZY7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeats containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZY7"/>
    <dbReference type="FunCoup" id="K1VZY7">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZY7"/>
    <dbReference type="eggNOG" id="KOG0310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021102_2_0_1"/>
    <dbReference type="InParanoid" id="K1VZY7"/>
    <dbReference type="OMA" id="TSENIWW"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="345" mass="37579" checksum="F71116C39AC3A452" modified="2012-11-28" version="1">MDFHPLQALPTAPRATSSINPHSRHFHSFRHPLFIKQNAPVTHIHFSPARPHRYAVTSSTRVLVYAPKTGKVVKTVSRFKDTARCGEFRKDGKLMVAGSDDAIVQVFDVGSRAVLRTFKGHNHHLPQVLSGSDDTTVRLWDVSTQECLTTLEGHTDYVRAAVFTAPHLILSSSYDSTIKLWDVRAPAQSNCTMTMRHGGAPVEDVLAFPSGGVAMSAGGPILRVWDLAMGRCVRALSNHQKTITTLAFDGSKGRVLTGSLDTMVKAYDVEEWKVVHTMRYPAPVLSLAVSPDDTHIAAGMSDGTLSVRRRDAKANEVVAVLKEPLVNEGPGVARLVPVAALPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1E5</accession>
    <name>K1W1E5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1E5"/>
    <dbReference type="STRING" id="1220162.K1W1E5"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="InParanoid" id="K1W1E5"/>
    <dbReference type="OMA" id="MPNTWQT"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="119"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="727" mass="80341" checksum="D11E40B322481E63" modified="2012-11-28" version="1">MATDPELLWQPAHPEKAQASLFRDHINKKYNLNLGSYEELWKWSCNNRGDYWSEVWDWEGVVGDKGAAPPSVHGVPCANNNNIRERTTDAQYVDEKALPVDNPKWFPNAKLNWAENQLRHVKEHPDDVAIIDTTEHCPGHEPAARRVTQKELYDLVSKVQQAMKAAGVQKGHRVAYWGVSVKTNNRSLGAIFSSAAADFGVDGVIERLEQIKPHVLLVSNGCVYNAKSHALLPLLPKLLGSLTHPPKTTVLINHLPDELNSQANIADFIDGGNDGWTSLVRWDDWVGQYKPQEISFERIGFNEPIWILFSSGTTGKPKAIVHRQGGMLIDSLREHHIQGDITRGSVFFYYTTPGWMMWQYLISGLGTGATVLLYDGSPLKDPGSLWRMVDEYGITQFGTSAKYIEQLSKHYPDVGAKHDLSTLRQIMSTGSPLPPHLFDYVYENIKKDVLLGSVSGGTDICSVFAGRCTALPVYRGEIQARMLGFALDSTAAVEHGEGELMVRQAFPIEPVGFWPLPAASLPDGDLIAPADCDAAAQRFKDSYFRDDGLWYHGDFVQITRSRSGNGGGLVFLGRSDGVLNPGGIRFGPTDIYSVLENPAFAAKGVEETLVVGLLVDGGADEKVILFVKMHEGKTLDDELVKLIKTSIRAARSARHVPAKILQVSDIPMTLTGKKIEVPIRKVINGAPTSSINPATLRNPECLEEYAKLGYEMRKEEGMLDHKDGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1Z5</accession>
    <name>K1W1Z5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1Z5"/>
    <dbReference type="HOGENOM" id="CLU_1176141_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1Z5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852225" evidence="2">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="25205" checksum="941A7B205AFF8C81" modified="2012-11-28" version="1">MGLRTTMGGSVIVYLLLATAALNQVSTPACSCVRAFSSHSGISLHSLGSNALTPFPPSRYRIAASAASDLARNLSPSSRVDPTLTYFLRFSLHTNRFDVLQRSIHLILQAPTSSASDTSHLSIGIPQPGSHTVSNSDPPKPRTLPRPTPDHPTPPRASLRSNSLTLTNHRLTRVPLLRCSALTPTHAPTPGSPFRPSACVSFTNHSTKSQSEPRSTAGPLSSLLLLLAFDSLPFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2C0</accession>
    <name>K1W2C0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2C0"/>
    <dbReference type="HOGENOM" id="CLU_2401233_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2C0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="93" mass="10413" checksum="0072944A25FE7A3B" modified="2012-11-28" version="1">MFTPLVKVEWDLDWDHPYIELVGNPAYRLTPYRRTTSDESVLSRGPEMGTQPPIPVSVLELAKSRLTNEASRHNMPAPASRGHCDTLNPPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2C7</accession>
    <name>K1W2C7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2C7"/>
    <dbReference type="HOGENOM" id="CLU_863782_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2C7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="34515" checksum="80A0D04D11A85DFB" modified="2012-11-28" version="1">MERECLGTKSQHRREPGGSEQQHQSRSRDPSLAWSIRRRRTRRPRARTGTAAHRAAAHADTAVAALVVRILRVVAHDPRVLRYAGVERRLLVIVGHQAVYCRPVVPSAAQGTPLVRSALDLLTACRRVVPLLAEPNRPAGDGLDGATPAQLDGSVVLHVCQEVFQRPASRLDRKCTAADRTRALVPVVLILTRVLEATVGPRLGVGNTNGGGAAAPPRRPVARATDNVVGAEAAIVEVDRAFGRAAVWCVGRRHGHRRIDDEASVVVGGVGPGTAGDFDGDRHGARDVVVRLNAAQPLIYIPTSRGTDKIRRDLMPTVANSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2G0</accession>
    <name>K1W2G0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2G0"/>
    <dbReference type="HOGENOM" id="CLU_1023731_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2G0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36062" checksum="E869DDA6AEC11F4A" modified="2012-11-28" version="1">MLSIHHQYFLHVVDAIFKHASSVPPSLAIMAQTCREWRRRSLSLFHTIRGYQILEEHPKPTVVVWDQFDNVLFFRGRSQLALLADCHVLDIRDISHAKPEPATFLPNLKTVRYQAHLDPERVTSGTEPLGASQIVCQNHVYSFDCPSPAVNTIVIHCAEPHANLRIWGADLVSEGRVNLSGLSELTRLIIIFEKPLHDAIHDGKSIINIVIAKDSNLSRKGWHSKGEPCQQLRLIRRLMQAAVHVGAAVVLVGTEAFSDDDVAEIHRFDFEGRIHAGADEPKGWYSFVTLDAYRRDVGEEEWAIQTCWDRPLFPHRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W306</accession>
    <name>K1W306_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_02393</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W306"/>
    <dbReference type="FunCoup" id="K1W306">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W306"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_0_1"/>
    <dbReference type="InParanoid" id="K1W306"/>
    <dbReference type="OMA" id="VRPCRYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="42"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD03283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="38438" checksum="147135DB758B77EC" modified="2012-11-28" version="1">MFAARRATRSVIPTLRAFQASRGYAATADVTSAYAGKKDANISEAVKKIYTAAGAPIVWEEVDVTPILKDGKTTLPADAVASVKKNTVALKGPLATPIGKGHVSMNLTLRRAFHLFANVRPCVSIKGYKTLYDDVNTVLIRENTEGEYSGIEHVIVDGVVQSIKLITYEASERVARYAFHYAQESGRNKVLAVHKANIMKMSDGMFLTACRAVAKEYPNVQYNEDLLDRVCLRITQDPAPFSQEVMVMPNLYGDILSDLSAGLIGGLGLTPSGNIGKDASIFEAVHGSAPDIAGKGLANPTALLLSSLMMLRHMGLNDYANKIETAALSTIAEGKTVTRDLGGNASTQQYTDAIIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3V0</accession>
    <name>K1W3V0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3V0"/>
    <dbReference type="STRING" id="1220162.K1W3V0"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428404_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3V0"/>
    <dbReference type="OrthoDB" id="2560219at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="220"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="645" mass="70932" checksum="DC1404D5DC6CF5FE" modified="2012-11-28" version="1">MRSARPPPGESTFPALRDASRNGTSATLLWLSQPPGVPWSGTMSSYQPNYTAVAKGRNPGIYASFEEALKQTEGFPGAYFRSFPDHFEASEWLKSESRKPANNYYNKFNRSKKKKAKLGPSRSLVTLSDDEPEPTMTDGKWSRSAKNQVEDYLRAMKETPLLPPQPSQSQPSISLVSDDEDGDEPVMKDGKWTPSAEVEVPEELASLSPQQKEVLDRILRGENIFFTGAAGTGKSHLFRAIIKALRGSIGGARQVAVTASTGMAALGSTEAWRKTDVLLVDEISMISGELLDKLDQIGRVVRRRSTPFGGLQVIFCGDFFQLPPVADHDGPKPKYAFDADVWDRAFPRSNRITLQQVFRQSEESLVTALEHIRRGRMTKEASALLTRCNRPVQCPEGTRPVQLYSRRYQVEQVNNQNLASLPGSPQVYRAIDIGGQTTNGYEVSQEQATRTLNSHTRWPESIALKVGAQNWAPGLVNGSTGKVVGFSTMADFGVDDDGAKKLPKADRDADGADRGPLYPVVDFEAKNGLKRPPVLVPTMEVSVENARNKMEAKRIQVPLILACRVKVDLQGTFDDGQAYVALSRATSLDGLELRGFNLKHIMVSKRVLAWAEEADEDDEFDAFFAANAEELDALTSSQAAPMGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6A9</accession>
    <name>K1W6A9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W6A9">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6A9"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005863_1_0_1"/>
    <dbReference type="InParanoid" id="K1W6A9"/>
    <dbReference type="OMA" id="NMYTPGC"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852291" description="SH3 domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1415"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1372"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1380"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1475" mass="155706" checksum="24834EFAFA6AF5DA" modified="2012-11-28" version="1">MRRNPPARRLGVFAAAATLAMASSSAPDSFPMVDFARMGTVNLGGAFSGLDWFSEQSPFAAASSSSSGTTFSSTGDTLVARSPDGSYTVVASANAGGTINALCYSSKDDTLYAAGNFSSLASTSTSNIVAYSLSKKEFSALQSGIPGTVDTLYCDDDHHEVWAGGTFAAPQGGSGANVARWDTESKQWTEVPFGGLNGHVDAIAPNQDGSSLYFGGEFTTQYADTTNTTYQLLRSIPSAPNNTVTTGKSGYLTPFTIPEQASQWSGLQINAGPASTNSQYNDQKALVCPESGTWMARDGSPAKIEILSHAYLTGAGIRISNGHVGQSTSKTFTVISLPDNHKLALTYTDPETGRDATCTDDCPLSTDPNVGAQDFLFADGSLSITGFDVHITSWDGDAAALNYIELLSDGAYSSAVEAENHSLCGRSNNRVNAAGNWEAGESPSEIAGTVGGYLKADVPKSGNSDSSLTLYPWVGSSAFYDIYLVIPGCNNLGDCATRTSVDVSVFPAQDTGAYLSNVQERVEDYTRVKIYSGWVEASTDAFSPTINVKLAQNPTGVDGDNYVLVASGVELVLTGVEANGQMPFPGSTTTRGQVTVANGQGISTPAVQFTGTAYTTRTDGVVMSGTMTMTAPPTLITTNTTRVNQTRTEIRNSYGVFEWPRSSNVKTDSLMPNSTETTLTHIGIALAMAKNASADGNQFKINTINELKDYIFVGGRFTSRTGSISNVLTIKKDEASPAALANDGLNGLVNTATVADNSIYFGGEFTGTAQGKTDLKYIAKYDPEAKSWSPVGGGVDGPVKSIRAIDGGLLVGGDFNNVMSNGSSSASTGGFAVYNFSTSDWNDSGIIYGNGSACLDAKDGFVAGRFTGFSRNSAQGIASIKSSNGKPASIEPVKGATFTPGSGSGKASNATNQKSRRGFISHFRPRMLSARADAPAINDPPAIAPATLTGAYWENGKSHVVVLGGNFTAQDNTVRGVAFQEGEKLTGPSPPVDGVVRALEVHADTLYVGGEALRVDGLSDSGVYVYDLKGKEWRKNYIPPLATKTGDPTVNYIRNRPKTDDVIVAGDFATAGSLSCAGICMWQNNRWQSLGSGLQNGEVKSFGFAEEKASSLFVGGSFTLDNKPTYAALFSFNNQTWTPLNGLPGPVLSIAVDDNKASNVFASGYGEGDNKPYLQRWDGSSWSEQNSSALLPGTNINNLAFVPLSEGHKHEARGAIEDNRLLMATGQVHLAQTGNVSSALFDGAKWIPYMVGSTAAGTLGAASGLFYSDRFFNFEVHHYLDRGIVVLVAMAIATALILLLILLILLAAYCMRRYERRHRPQEIYEKAPSEVSSTHQIMLNSVQTALEQSLLTPGGVARAGAAGGVGSLAAAGAAKRRSSHRDSDHSHYTDEEEHHRPDADEFLAAGAGSDADSDDGGRETVMRYDFGGPDLETGELSMRAGQRVIILDDEQSEEWWYARDPATGREGVVPATYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W723</accession>
    <name>K1W723_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000198">
        <property type="protein sequence ID" value="EKD04668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W723"/>
    <dbReference type="HOGENOM" id="CLU_2147627_0_0_1"/>
    <dbReference type="InParanoid" id="K1W723"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="112" mass="11534" checksum="F3081DFE423F0FCA" modified="2012-11-28" version="1">MPVTISTAALSRDRASGTTSAWSSGGRLSPDRLPVHAHLAAVTRQHAPGTGVVSHRAAMTTSRRFGPLGWVGVNGRIGSGIECSCLVAATLQCKTNTPEEAGSRLRKAPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W962</accession>
    <name>K1W962_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Structural constituent of ribosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W962"/>
    <dbReference type="FunCoup" id="K1W962">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W962"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_3_0_1"/>
    <dbReference type="InParanoid" id="K1W962"/>
    <dbReference type="OMA" id="RRDYKIC"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="98" mass="11048" checksum="06D42C79DFBF1001" modified="2012-11-28" version="1">MSSPLSKELRGEHGVRSIPVRKDDEVLIVRGKYKGREGKVTQVYRKKWVIHVDRVHVEKSNAATAPIGIHPSNVVITTLKLDKDRKAILERKGRKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9Q6</accession>
    <name>K1W9Q6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9Q6"/>
    <dbReference type="STRING" id="1220162.K1W9Q6"/>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400190_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9Q6"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="151"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="688" mass="74571" checksum="B7121BE7BB839941" modified="2012-11-28" version="1">MPSTRPPPAPARGRVAYPSADAYTAGDAGAQPTLGESSTTQAQAIQAAGQSYENDKPISSGGAVGLLRRRTTTKRKPQPSGDSPDARAEMSEREKSTQGLKTWWKAFSSNPKSSAPTRTPVTMNTRLQFGVPLHVVLQYAGMSISTQAPDGSLNMWGEVPIAVARCGAYLKGKTDIEGVFRVSGSAKRMRDLQLTFDTGPDYGLHLDWSETMYTPHDVATIFRRFLTQMPEPVIPCSFYNRRIREYKRLIRRMPAENQFLLLYVLDLLGIFAKESDKNLMTAATGHPPPPRPRHAASGERRLEGRRQVPDRSRGVVRLWHDYGELYERFGADRQRIASRQNSGVIPTVGSSNDPGARPPSRQEASRQDNREAPAAPPSPTPLGRRGSGQDMRTDSPTRGASRPPVIRRESGDSYKTALEYPAGGAGGISIPTAVPEHAVASNHAVAQPRPIPSSSKRENVGASSSSLAVSGLSPRTSSLAARASLKSPASPRTQSPHTARTPTSSRVQSPSFTSPSRPQPRRADTDFMLPSDSDDEAPKGGYYIVEKPRSPQPPTAPAKTLPKATVTDLLPEQPKPRRRGTSRQQTRSADPVSPSPSRRRAGVAATGMYPSDSDDDAPAGGYIIYENKKVSPSTTTLPRRGALWNGDGRTNSPKPTAGGATGLLRRKTLPTKRVSDFTNRMRRVVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9W5</accession>
    <name>K1W9W5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Siderophore iron transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000089">
        <property type="protein sequence ID" value="EKD05563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9W5"/>
    <dbReference type="STRING" id="1220162.K1W9W5"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272270_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9W5"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="887"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD05563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1187" mass="130106" checksum="B792FC183B9B3A40" modified="2012-11-28" version="1">MDKTCPDCGRVFTKAAHLTRHRLTHDQQRPFSCTACGKAFARPDALQRHMRTLHGKRQRTGSEAQSDAVTPPSSGFDLSATDPLGSLGFPPLFPLPVFANTSTPTTQSLDEMVAGWLSQDGGALATENALAAAFSDQVNWEPDLTGTFYTEPQETYREPRRRMMNADTWESGMSNPQHQDISRPASPPPREITSPEEVVAELHINHTFLEACLHLYFRDFHPSFPIIHRPTFERDRTPPLLLLSMCSIGCMFVGTQAARDSGVWIYERLHHVIVVTRDAKMATEESRVAVMLSALLGQCFSFLYGQPKQMLTAESFHGSLSTKARRSGLAKLQRNPIPDLDVESDKLKKRWREWAKQETLRRLTLGLTIHAAESTIYSGRARFMVGQVCDPDGFSDALFEAKDAETWRSIALGGVAQTPEHFLPSALLAQTIVNIHKARELAQTPFGQELPLPEFYKHMMQLAGDHGIVAVLESPRNAAPDHLRSLTALWHYTCVVRVAPQDLIQEAAGRGGNPTSDAVAKTEQWANTPAARLAALHCGHVLHYAADLHDRGFLLPSNAATLVLPSLLAAVRRVVRRPRAERFVAEGNCSIQVAGFCDGKEKALDIVMWQPPPSSLHPVGHRRDAQRRPGKSLDLKRPQVGKGYDWIRIVWDGVGRCGTVQNQCGAVWATTAMAPSLNEDEKAGFDHQEDVAEVDLVYAEENEEPVFHRRTYIALLALFILNYVQIVALNGPPGICRQSLVPLLYVLPLPALTSQAFASDTFQARKTLLIVTCTISFIGAAIAPGANDIYRVIVAQILVGFGFAAVPLAYAIPSEWLQMGLWGAAVIGILLGYSPPKRHTRLDHLSFWQKIGKLDLPGMGLLAVGLSLLLTGLTLGDNPWEWTNVRVLTTLIIGIVFLILFGLYEWKGTKTGVLHHELFTLRTFPLCIALMFIEGVMLFSIVVIYPAVKLFETDALLAALRAAPFWIGAALGTVFFGIWSSKMRTIRSPMFVGFLIFTAGLVGMATVQPGQSANPIVFDGLAGLGYGSPLILIVAGVQLATPHHLIATATAVLTSTRAVAASTFTAIYTAAYTTQAKTKLPRAVSSAASAAGLSQHLDAFVEYAIADNTTAMEAVPGVTASIMNAGLEGLKQGQADSYRIVWIIAAPFGILACVFVYFLDDMRTLMTYRVDAPVEELHSKREEREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA18</accession>
    <name>K1WA18_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA18"/>
    <dbReference type="eggNOG" id="ENOG502RBDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1455378_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA18"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="186" mass="18382" checksum="4C739F2689480294" modified="2012-11-28" version="1">MGNCFSSKKQGQVLGSGPPSAGHSAGASAPSVGGTPVSPTGNTIGGSGNPDDPRAAALRAAEARAQAVSVKACCSLGREGAWSAAGRGGTDAICAGLQAQAGVHGAAPSPPNTDPAMRTPSLRSGVQGCPGMIQKHQAVANAQAGNRGVSPTNAKAGQLSQKLAMERRTSSSANVKGNPNERMMWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC75</accession>
    <name>K1WC75_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC75"/>
    <dbReference type="STRING" id="1220162.K1WC75"/>
    <dbReference type="eggNOG" id="KOG2342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526969_0_0_1"/>
    <dbReference type="InParanoid" id="K1WC75"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="504" mass="55800" checksum="65408CD4BAD5B4BB" modified="2012-11-28" version="1">MATSRVTLQQASDHSSWESKLEAAEVSKSDLNALVFDYLVVEGFSDAAVEFARETGIPTTIDQDMIQERMEIRQAVEDGRVEEAVRRVNELDPEILDTNPPLLFHLFLLRLIELIREDKVDEALQFATLELAPRGAQNPEFLADLEKTMALLAFPHLARDDHPADPAFASITQLMKRTQRVKVAKELNAAILESQGQGMETKLGGLVRLMLWGEERLNKAGIGVNDDRGRQWADIVLNEAILAANRDEFLDRPTAPAEWHDFDGAAPASQVLSGRDLGTAEKGTTNIRYPIVATPPDPPSRGMLLKSFLSAAPDAKVSVSDFLKDIPAKDYVGFNLLLFDLQSSPAEVGYLSNRPEPTQLTPNNDSCQGISNSPWDQPYPKVTEGEERMAKTLEAWAMEGRNEEDLVTRMMDLLSPAPPVTSAKDLFRATRVQPVIIGPDPNAPPADRPTEGGRWYGTRVSTVIIVRDDGHVLFVERDIALLDHSGQVQQGHKERRVAFKGDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCS5</accession>
    <name>K1WCS5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCS5"/>
    <dbReference type="HOGENOM" id="CLU_2361232_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCS5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="96" mass="10127" checksum="C3A940E0AD824BD1" modified="2012-11-28" version="1">MPATRKVSKSIKQEDVKPYDRPKSPPASSSKNKARTQLPDGSKAALARAVVAAGVKALTNEEAAQISGLSLAQVKKQLEAGRGVRRALLEFADTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEB6</accession>
    <name>K1WEB6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CinY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000354">
        <property type="protein sequence ID" value="EKC99963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEB6"/>
    <dbReference type="STRING" id="1220162.K1WEB6"/>
    <dbReference type="eggNOG" id="ENOG502S0GM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375070_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEB6"/>
    <dbReference type="OMA" id="CEHERIT"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056862">
        <property type="entry name" value="VWA7_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25107">
        <property type="entry name" value="VWA7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWA7 N-terminal" evidence="2">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="703" mass="75137" checksum="827F379A06B1FFCA" modified="2012-11-28" version="1">MALRLRTIPAPLTRSVPSFASEIPVFASPGCWGEPGPLPGDRCNVQRARARTTDPPKKQIQKVHLASPPPPHHISQHLAAPMVAALLLLAPCVAAFGTINTGGQQAEHERITRIALQCPDGVYHDDGSCFEPISMLSFAGGNGTFGAVGAPDGGADTLKSQAHCDDADYIDYAKWGLNGTYPQSKAERNRKLRECYEHLKGHWDEGIKGASELVDDYGALVEKEAKLADENGKGIPCVYSGSLSGRAKCDAFEGLGRSLHGLQDFYSHSNWVDYAQITPTQNTPPGLGMTDLAPFLSMINGTGPSDTNVPSDFSTGCFNLFGHDTVEGAAACEKDGRYITHVVLNKDKGEIIVKPLANITIDAGTTLTGEARTPRGNISDNFERAVHGAVLESRRQWADFRQKLIDTYGPTRGRLMICALTRDQPQRDCGGGRSVALVLDGSSAAGVGDALKNKTQSTDRVGVFDGRGAFSAFGSDAKLESLQGGSLAKGLRLAVDTLNGTKTDHIVLVSSEDSADVIEHVQAAKKKGIRVSYGLLTEKSKSRRSLRFWRRADPPQTAVAAAVLSTGGTYAVLADSGQKDTFAQHVFAWDEGSKTNLHRGLIVFDDGDRDWSHQVEDKRNVNVTVTAYNGSATAVLREDDKERARGKGSTVSLQAQGDDSTVEARVEPDGLYSIALDYTSAAIKATSSLVGPVAAVSLAYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEK5</accession>
    <name>K1WEK5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05697</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEK5"/>
    <dbReference type="SMR" id="K1WEK5"/>
    <dbReference type="STRING" id="1220162.K1WEK5"/>
    <dbReference type="eggNOG" id="ENOG502S3AW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="InParanoid" id="K1WEK5"/>
    <dbReference type="OMA" id="KIFCLPT"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005137333" description="Cutinase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="221" mass="23049" checksum="7A9557895F3D3648" modified="2012-11-28" version="1">MKFLALFATALSLVAAAPTPVEIDERQLLSSTRNDLENGNSNNCPDVIFIFARASTEIGNMGASAGPSVASGLDSRFGDVWVQGVGGPYTAGLAENFLPAGTSQAAIDEAKRLFTMANTKCPNTPIVAGGYSQGTAVMSNAVSELSATIKNQVKGVVLFGYTKNLQNGGGIPNFPSSKTKVYCAATDAVCFGTLFILPAHFLYTTDASISAPIWLARQINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGX2</accession>
    <name>K1WGX2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGX2"/>
    <dbReference type="FunCoup" id="K1WGX2">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WGX2"/>
    <dbReference type="eggNOG" id="KOG2976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597436_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGX2"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="169"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="266"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="550" mass="60697" checksum="7FB597203440430B" modified="2012-11-28" version="1">MATATVQSSTNLFRQLAWNASVPIEVRLADGEAPGAAVDKYYVQAPRYTYLPLLLPQIKENLVSLALDDEQLAKTNEAQWWFEEDAEEPGLGGLGACRWLDLDLGAALLTATEILADRRHWPVDLLDLNATISRPVRRDATDPDARPLKLILHLSSPPTDKLTLPAGVESCKAAFTSQVKEADFVRWGNTKRVTGMRRQDLEAGWDGVMGGDYDLHSRMGSRLVPMPIPLGSSSTPSNVPSRPPSTEPGQTSSVPKLESAYAARSLPIKIYLPDAPAMQHVVPPLTDGRPTTLLSFLRQHYPLLFPTSGEPYALAVPYVLGIVVPPDAEVAWLASCMCGADGWVRIGLGLVGDISVWNVAGNASEASSDRARDRERRWAMLDQLDHLVLVNFGPGPRTRESEGGEDTKAGTMNVSWSKGTAGTLDFYAWTQRPVLRRPRSHQFFRNEGQVVKQSLGSAVALGETEVGYCAPVVNGTLLRAESRECLADVPPRRPTDQREEHESARAYERMSVKAMQGAELAEGEQRRSWRRRDERRSQLSFVRQRSLFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKN8</accession>
    <name>K1WKN8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7alpha-cephem-methoxylase P8 chain related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKN8"/>
    <dbReference type="STRING" id="1220162.K1WKN8"/>
    <dbReference type="eggNOG" id="ENOG502RZAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_3_1_1"/>
    <dbReference type="InParanoid" id="K1WKN8"/>
    <dbReference type="OMA" id="YYEESIA"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF4">
        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33671" checksum="863A36C41BCFED95" modified="2012-11-28" version="1">MSTSISTGETKGVFNYLDPASLSSGEKPWSKADTQAFKSFSELPVSYAVHDIRASPELSNPDLAGFSFHSSPSSVPVDEVLSSGLAEGTQTRKDYYAEIEAAIKQQLGAKDVVIWDHTMRVRDPSSARQPVQSVHVDQTPSAALRRMKQHAPQFAADVENGRRFQLVNVWRPLGPALDHPLGLLDARSVAPEDLIAVDLLYPKVYERGKEVLPSPESLRSREGYEPRGETYRVVPKEGHKWWYVKDMKSDEVVFIKCYDSEGETEPNGRKGVATSSPHSAFEDPAVQNPPPRKSVEVRCLVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM05</accession>
    <name>K1WM05_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM05"/>
    <dbReference type="STRING" id="1220162.K1WM05"/>
    <dbReference type="eggNOG" id="ENOG502SBJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794978_0_0_1"/>
    <dbReference type="InParanoid" id="K1WM05"/>
    <dbReference type="OMA" id="RPTTKCG"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="230"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="301" mass="33110" checksum="5FE9DAB9DE036C0D" modified="2012-11-28" version="1">MSDSDSDSDDEFFTAKARTGLARPPIRDDSPIEVGDSEPSDDEGPHSDVELVETTTSSKTTNGKGKGKAKEVRRRVELTPPPETIRDPEKEARMRQSLLVRVRKPSITMRSRGFSTSQGRIVVALAETLNKPTSDIVLVHNGHRIFATNQSPIELGIGDQGQLKGYEKAIWRKVQDEEERKRRERIAAEMSPAPDADDGEAGSPAPVPASDDDGTAPLVEPPTEDTVEKIKFTVRGEEGNLRLQVRLSTTAGSICRHYCNKYGITGARADNMRLHFDGESFDPETEISEMDLEPGDLVDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMK1</accession>
    <name>K1WMK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_03358</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMK1"/>
    <dbReference type="FunCoup" id="K1WMK1">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMK1"/>
    <dbReference type="eggNOG" id="KOG0434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_1"/>
    <dbReference type="InParanoid" id="K1WMK1"/>
    <dbReference type="OMA" id="EIIVIHK"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000176">
        <property type="entry name" value="Isoleucine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="21"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="707"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD02354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1094" mass="124984" checksum="FB1D3149DEE2D98B" modified="2012-11-28" version="1">MSFQKHDPSKPIHIPTAEHNVLNFWNEIDAFHTSQKLSEGRPEYSFFDGPPFATGLPHYGHLLAGTIKDIVTRHAHSTGHHVERRFGWDTHGLPVEHEIDKKLGIKGKDDVMAMGIDKYNAACREIVMRYSSEWKSTVERMGRWIDFDTGYKTLDTTFMESVWWVFGQLWEKGQVYRGLRVMPYSTGCTTPLSNFEAGEDYRMKSDPTVTVMFPLVDDPNTSLLAWTTTPYTLPSNLALCVHPDFTYVKIHDIERNHNYILLESLLGTVYKEYANGKKPDPKKEPKFKKIGSFLGKDMVGWRYTPMFDYFTEQYEDRAFRVVSDTYVTDSSGTGIVHQAPAWGEDDHRIAVANGIVREDEIPPCPIDEVGRFTDEVPDWKGVYVKDADTSIIKTLQSKGRLVARGDIMHSYPFCWRSGTPLIYRAIPAWFVRVAKLSDDLVANNEKTRWVPQHVGDGRFGGWLKNARDWNISRNRYWGTPIPLWASDDMQEIVCISSIEQLEKLSGVTGIKDLHRESVDGITIPSQQGKGTLKRIEEVFDCWFESGSMPYAQSHYPFENQDNFKARYPADFVSEGIDQTRGWFYTLLVLGTHLFNTAPWKNLIVTGLVLASDGKKMSKKLKNYPDPMEVVEKYGADSVRLFLINSPVVRGDNLRFREEGVRDVLSNVILKWINSLNFYLNQVELFNQAQGTKFMYDHDAPKSTNVFDRWILARCQTLIQTVHHEMDNYRLYTVIPRLLELISDLTNWYIRFNRRRLKGENGVEDTKAALNSLYEALYTLSLTMSSFTPFTSEMVYQSLLATTPAPKDGSDVRSVHFLLFPSAREEYFDPVIERQVQRLKSVIELGRAIRDKRTLKVKMPLKELVLFHHDQEYLDDVKSLEGYVMGELNVHEIVYTRDEAAIGIKYKANADWPVLGRKLRKDLGKVKSHLPKMTSEECKGYLSQGKVSVNGVELVEGDLVVTRYVELEGERAEVYETATDGDATILIDVRRHDALEHVALVRALTSRVNKLRKAAGLVPTDRVDVFYAYDEGEEDALAPAIAGSKDALLGTIYAVPLEIAQMPADRKVIQTEVRAKDIDDADRAERFVLTLAERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP16</accession>
    <name>K1WP16_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP16"/>
    <dbReference type="HOGENOM" id="CLU_1866526_0_0_1"/>
    <dbReference type="InParanoid" id="K1WP16"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="137" mass="15181" checksum="A0E8BDFA4ABCF067" modified="2012-11-28" version="1">MGQPSCSSAHLTTSDVWTPATTFSPLVPDQADGGTSGEPPSHRTRTPKAAMLTTTKPTLRQQQEQQLRLLYGLDEHQASKMLDHILGGCDRIEEERRHLARVSRRGGVADEAELKTQPTRVRHCNRLRVVPPVLIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRQ8</accession>
    <name>K1WRQ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02008</name>
        <name evidence="3" type="ORF">A1Q2_02009</name>
        <name evidence="4" type="ORF">A1Q2_02010</name>
        <name evidence="5" type="ORF">A1Q2_02011</name>
        <name evidence="6" type="ORF">A1Q2_02012</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRQ8"/>
    <dbReference type="STRING" id="1220162.K1WRQ8"/>
    <dbReference type="HOGENOM" id="CLU_2074792_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRQ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="118" mass="11945" checksum="EFAF233B733BD52C" modified="2012-11-28" version="1">MPPRRATGQPEGQPSAKKPAMDLEAIKAKVAAQKQALQARLASAKSTSSSPKPELGPAAPPPSAAPAAAKNDDIAARMAEVRARINAKKGLLAGAAAGPSRPDSRDSRDSRDSRGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU28</accession>
    <name>K1WU28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_01293</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU28"/>
    <dbReference type="FunCoup" id="K1WU28">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WU28"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="InParanoid" id="K1WU28"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000013">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001752">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021934">
        <property type="entry name" value="Sox_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51516">
        <property type="entry name" value="SOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sox C-terminal" evidence="13">
        <location>
            <begin position="58"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="727"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD04409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1161" mass="127929" checksum="E77DFD25B0E08F56" modified="2012-11-28" version="1">MVKAAADVKKATKQTTLAAFFGAPKPKPAAPSPATQATPKATPKVKTTPASKPKTPKAAPTPAAASTSPPSSSLRTPPSDPIEPEEVSANVQIARKPQPERSASLSPPPEIVSKPRSKPKAPPSPAAEAMDVDEEEEEVFVPGRRKRKAVKYVQSDNDVSEAGVTSEEPSSPSVASVVSEASPVKKPKKAPPKKAPLKASPSLSRPPLSHASSSGAADMFLTAAERKKIQAKDDKRNAETCFEFLVDIKDKDGNRPGDPEYDPRTIYIPKKSWGSFTPFERQFWEIKQNHYDTVLFFQKGKFYELYENDAAIGHQEFDLKLTDRVKMKMVGVPEQSFEFWAAKFLAAGYKVGKVEQAETAIGMEMRTTKGGGAKEIVRRELAQVFTNGTIVDGTYLTTDEANHCVSIKESSLGPNLPSSFGICVMDASTGSFSLTAFEDDICCTRLETMFRQIRPKELVFAKGNLSVVTMRLLRNILPPSTLWQSFKEGKEFLDVDDTIAALKEYFPEGELPEAITAMTENHLAVEAVGGLLYYLRTLNLDKDLISQKNFSVYDPIRDGKALVLDGQTLGHMEVLMNNEGSEEGTLLSLLQQCHSPFGKRLFRYWLTAPLRDAAAINARLDAVDDLMHAPSFMSQFKELCKGMPDLERLVSRIHAGSIRQLDFVNVMNHFRRIQSSVNRLLEIAEGFESSSVAGLLRSAPDLGPHLQHIQNMFTQVTDEKTIAILPTEGADEACDEADAAVAEIEEELNAAMEQTRQELKLKTGEIRFWHSAQGNKEIFHLEIPAKTKVPPKWTKCGSLKQVARYITPVTQPLIRRMQEARETQSIAKKNFFRHLLSEFDKDRDVWLKMVKVIAELDCLNSLARASFNLDAPKCRPTFVESDQAFIDFEDLRHPSMCLKRDFIANNVQLGGEVPRTTLLTGPNMAGKSTLLRMTAAAVIMAQMGCYVPAASARLSPLDKIQTRMGAYDNMFASASTFKVELDECSKILREAGPRSLVILDELGRGTSTYDGMAIAGAVLHHLSTHTLPLGFFATHYGSLTDDFAYHPNIRNMHMAVHVDDTAGVVFLYKLIKGHAESSHGTHVAKLAGVPDAVVARADEVSGEFFEQFQQKLESRRQSSLSIPAQADFAWLVHLAQGKEEATTATVAEQLDVVRKAVAAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUJ6</accession>
    <name>K1WUJ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUJ6"/>
    <dbReference type="FunCoup" id="K1WUJ6">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WUJ6"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="InParanoid" id="K1WUJ6"/>
    <dbReference type="OMA" id="SYKGVRH"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="204" mass="23759" checksum="265A9A6BE062D5DF" modified="2012-11-28" version="1">MSFQPPAQHEQFQHILRLLNTNVKGTGKAMYALTEIRGVGRRYANLVGWDEEDMKRTTESREYDVGRLDVDIVVRWIDARISVWEDQVGLSRAFCKKADIDMSKRAGELNSDELERIVTIMQNPTQFKIPTWFLNRQRDLTDGKDSHVLSNQIDQKLRDDLERLKKIRSHRGLRHHWGLRVRGQHTKTTGRRVGARTIATKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUV0</accession>
    <name>K1WUV0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUV0"/>
    <dbReference type="eggNOG" id="ENOG502TM73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375058_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUV0"/>
    <dbReference type="OrthoDB" id="2591431at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="758" mass="82018" checksum="EFB5551AE358A81E" modified="2012-11-28" version="1">MSSVQWKGDDGPFHLLLTPTTFEQYGYNVWVPSIPNGTNKYDLPINLPAGLQFVVTVWGQSGVEYAGTTDVLTVLPSHNKTTSCFLNNNQINDLYTFAFNISDSHDSRPPQCSNLTISWPTSLESEIDNGSDTNTRTESWMLDRRDEAATEPLVELDMELEDVEARGDNDDFSSGANRTTGTWNTTTPPTIFGIIPLGNSFSIPVTYDKDREKQFGLPDQYLSHNPTTWTEKGVTSLNWTVNLAKGTRFILVAGIGSQEQWASGGSSEMMTVGQGPSTCFNVGGSKPSVTLSGTSTGALEPTETIPDPEPDNGSDNQTSSRWTGVILACIFSVLGTALLCVLFWCCCRVRRERRQAVKAGRPKPSFVNLASFGKLDRKYKPPDTQLDLMGPEHRDDASDGTPTHTVFGQRPYSTVTSHGYDRGSMGSESFADYNGYPYSPPPVGTRNSLYDAAVPYRSSMYDRTSAYDRTSGYDRTSGYDRGSMYDDGVQPYYYPTTGSPTTTSPPAAAGSSLPRRNQSYDHMGDFMGRQPSMDGISYPPMAHSLPPLKRQILLGEGPEEHNDSTEQLVQLKRDTIAALDRPGESSRGSSTTSVPGMLTVDTNIDPAMGGVSPSPISGLEEDNDPQGAYVVHRDAGRIPNSPTAASSRVVELPPRYEELNWDREASGDVIEEAEANLGTVLASPSSPAGVRHPLPLPPGARSPPQSRSPGPTRSSPGPMSPRTRSSGPGSPLSGVSGSPLGSPRTAQEPRQREQHGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVF0</accession>
    <name>K1WVF0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">A1Q2_00873</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVF0"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="reaction ID" value="UER00071"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:L-leucine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF00694">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
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        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LeuD/IlvD-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="11"/>
            <end position="472"/>
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        <location>
            <begin position="534"/>
            <end position="657"/>
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    </feature>
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            <begin position="509"/>
            <end position="535"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EKD04819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="756" mass="81833" checksum="9C1E1DFC87902795" modified="2012-11-28" version="1">MTSSAPRTLYDKVFDDHVVKSGNGDTLIYIDRHLVHEVTSPQAFEGLRNAGRKVRRTDCTLATVDHNIPTTSRKTFKDVSSFINEADSRAQVEALEQNVKEFGLTYFGMSDKRQGIVHIIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPQAKSKNMRINVEGKLPEGVASKDIVLHIIGVIGTAGGTGCVIEFSGSAIRALSMEARMSICNMAIEAGARAGMIAPDEITFEYLKGRPLSPAGEEWDKAEAYWRSLKSDEGAKYDIEIELKAEDIIPTVTWGTSPQDVVPITGNVPVPSEMPANKRQDAEKALKYMGLEAGQPMESVKVDKVFFGSCTNGRIEDMRSAARVIVASGKNGGPTQVAEGVYAMVVPGSGLVKRQAEAEGLDVIFKKAGFDWREAGCSMCLGMNPDQLKPGERCASTSNRNFEGRQGAGGRTHLVSPAMATAAALTGHLTDVRKLMGEHVSDDGGIKISKYADFLEPLIPAQAAPAGEEREDPDEEAKAEPAPSGEGQPKFTVVKGIAAPMWEANIDTDKIIPKQFLKTLLRTGLGSALFWPARYDVKTGEPIADFVLNREPFTKSKLLVCTGPNFGCGSSREHAPWALNDFGIRCVMAPSFGDIFKNNCFKNGMLPLELPQDALEQLYKDAETGAEIAVDLENECVVRPKGEKIPFKIDAFRRHCLVNGLDDIGLTLQNAKDIDTFEAKRSANWPWLDGAGYAKGNRVVPLRQKAGKNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWT5</accession>
    <name>K1WWT5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000142">
        <property type="protein sequence ID" value="EKD05154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWT5"/>
    <dbReference type="HOGENOM" id="CLU_1225527_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWT5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="23748" checksum="25658D3EF9875A81" modified="2012-11-28" version="1">MFPMFNSPPPAPAHPSADSSVYKSCSCSCTSKKTVADQPTSFPQTRGRLDADYAAYLTGKGGAIVNCPEPPRAIIAQPVVRCPAPERLSRPTSPVRTERRDEQPKPAPCSYPPQAPAKWYDDTVTPTASRPPSPRKRQCEDSPALLAKRMCMKKKAASAASANSSRAASRVTSPVAEAKDEKPAVVKSETPAAATAATAVQNGGPGEKAAEPAETQTADTKVNTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWV2</accession>
    <name>K1WWV2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWV2"/>
    <dbReference type="STRING" id="1220162.K1WWV2"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWV2"/>
    <dbReference type="OMA" id="VTLQMAC"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="4">
        <location>
            <begin position="219"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="54343" checksum="3FEE3D22F3DC0B9A" modified="2012-11-28" version="1">MFRGSNSSEHRIPAQQGMPNATSVATPTTGTPAAGTPPTGAAAANGQQDPHNLASMFLNAVAQQAAGNGGNIPGLQNGGASSSSAPKAPQAPAGPALQLVTSSSTFDQLLKTSKALVANFTNTAGCPPCRMIKPAYESIAEAHYPEFGPRGARFVEIELDRGDGQNLASRYGVRATPTFMFFKDGKKVDEMAGADKRGLENKIEAFLDDCFPQHAHKRLYLPATERIKTNPITATATPNFTALFGKLEGFAGAAGKQHVDVLKNEVVPFLEGKGGDAVGVVDKWTAASGALLQSLKPAEVFPIVDLWRLGLLNDGVVRVLTPRVGGPSDPIAPILALTAKELKQGVAATPRPLLLTTLRLETNLLAPLPLATAALARPDDLLSVLVEALLHPDVGVRKAAADVAVNAAAWRHRVREATPQTPDAPEIGGEDWETELLSALVEAIAREEDSDTGHRLLVAAALVMYLNPGWDEGIQPLLEVLGARDTIDKAARRWNNKDIRKLADEITLKMLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXH0</accession>
    <name>K1WXH0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000092">
        <property type="protein sequence ID" value="EKD05404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WXH0"/>
    <dbReference type="eggNOG" id="KOG1739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002853_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXH0"/>
    <dbReference type="OMA" id="WLTITHD"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF54">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1582"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="3">
        <location>
            <begin position="31"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="3">
        <location>
            <begin position="481"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1652" mass="179627" checksum="3B129C02D76D7FB3" modified="2012-11-28" version="1">MPVDSLDDGIRLETAWIEALNNSVSYFRALLSSSGSSAWKRVSSNPATPGSPVRETSGSAKGKATSLGSITTKDVVVHRRNGKGGEVFRAVVEVDCGSDVNVDTFRGCLATPETRAVWDRMVEDAQLLDLLDTNTRVTRTNYRLGWPSRYLMAALLPADMHSPRDAVTISKSLVDQHTLIDVSTSIPRSRHEPAYLRPAPPHVRANVSLMAWCIQLPSNSSRSADPPLPEGKARITCFWSWNPKGTWAVGGAVPQHLPTVLVGLVNYIRDGSEKVPVLLSYGNDVSITGLHYDPGRVTLSANYAVVRSDDAKDGTKRQLEFGVSSTQGWDVQVLVKSQNGEESPSLSWTSFVGQSPPSISGSAPPKRLVLRLLHSQLQPGEELVRVKVTIEQTVASAEAAAQVKVNGIPVPVLPMTTTPLKELLGGSPGDSAMSLPTVDTASSLRTGSDDSTERQRLARNGRSSAVERGINSLIKRNYIYFTSLLQEPEQKWRPVAESKGVSVHQLDSIDRTLVVFRAEAVFVGVSLWDLFATITTPGARYWWDKTYDEALLLEDVNEVTDVWHFKSKASWPVSARDSIMVRSTYKSPTSVHIFGFSTEDESLFPVPPSIDPNVIRTQIDLQGWSIEALSPNTTQVTLLEQSHPGGWSNKSSIPQAMMTTLAGLGEFAIKHGAPPVATRLGGAKAVSSNYDLDKETYRFEYEPAATRRSFSSSTNTAFSPPGTPDLRGDGISTFSFDTSDSGRSIECGLRIDADTWANSVSVLVDPPPKNVSALKRHRLSPNCGGLWITVEHDAASLTDRTVTITVRRGPQSATGKVSLTVNGSKLKIDNEDMTQADVQQLKKQKRSRPSRSALDQPPALSPMRKRQSTASLRGAAQNGQPQGPPNGFKPFYAPFARLYNAAAESTRSIVPLAAPSPVPESGTSPVDAALTALRQICRINADRDGESTDPFGWQPVSDRDGLKVEKRIVSHVSDSIPVFRAGRIIEGFTAEEVSSAVSSFRKDDYFEKPVRLQSYGYGITTTMATAHTSFPFRDRLALVATVVARVGDSPPTSPSVASHSPLSTIYHASTSSFDPSTLGLDAAKYNPSQLSPVNVIIEGWILETIDPYSHEQYAIPSTRCMYVGAMDYSGNIPISVNNMLNAGLPRSLLNIENLLKTHGPPSRSRWPPMCVLVPETSARGPWGLEGTESYKVPVDQVNDGDDYVITVTVQPPTCRDRPHPSLRHADSRGSMGSTMRSQGVNLTEDVRRGRRDLIVAEIDVASDFIKGGCEIAIRAVSLPEAYYGTGTESNMLPLTFPGDKLSLPFRCTVISLQPSVLQAASLDPKTQTRHLLRITLPTSGYEAPVNDPLTGSTSPLPRPRWLLDLINDGAVVQVRLQGRKKEPPAYMFEGAELQIEDERKLMPTQQLKEPSKLRPPQLVPASSAVCTTKLDKPLAASKEYLPDKPLVTPAVVEEEEDAESESTKTPTNEPAEPEKKLEVDTKPIPSNGASEPEPKTAPPAPYSRYNFWRYGALRFSYSAPVSQDASPVKSAAPLPSEKASVATAVPGPSSASVATATATNGEQAERATRDRIPLTRQNVVSVPLPAVIILCVVCLLLGSLLRSLITESDFVIYSKPGTEPPAGEMWRELKRLGEWRIGWNRDLIVALAQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V156</accession>
    <name>K1V156_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase (NADP+)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V156"/>
    <dbReference type="STRING" id="1220162.K1V156"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="K1V156"/>
    <dbReference type="OMA" id="CDDYIAT"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="363" mass="38877" checksum="FA272B8235B47D03" modified="2012-11-28" version="1">MGEPFTQIDAWYSNDPQKPLQFGKLDAKPIEDYDIDVKVLYCGLCSSDVRVLSGAYGPVHEEVCGHEIIGTVTRVGPEVKHLRVGDHVGIGGQCDCCTHCAACERGDEHMCPGLTFTIGMIQGPYKRGKAKGRLGQGGFAKQWRGNARFAFKIPDGVELASAGPLFCAGTTVFTPLRRFGAGKERNRVGVIGLGGLGHLGIQLAAALGADVTAISRGNSKEEDARKLGAKHYIATGSDLKKDFEKHQGSLDLIICTINPPDLDVDAYFTLLSAGGLFVPLGIPHKPLVIDPIGLILGQKGVVGSALGAPQDIKALLELCAKTGVKPWVQLWEFSDINKAIEAFNRGEPRYRFVLVNTDNGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2B9</accession>
    <name>K1V2B9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="6">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">A1Q2_07605</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2B9"/>
    <dbReference type="FunCoup" id="K1V2B9">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2B9"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_1"/>
    <dbReference type="InParanoid" id="K1V2B9"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="26">
        <location>
            <begin position="316"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="26">
        <location>
            <begin position="852"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="27">
        <location>
            <begin position="1117"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EKC98059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1273" mass="139275" checksum="84EA9A8C0E6F6A4A" modified="2012-11-28" version="1">MLRSFSLASRAAAARRSVPSSTRVAFGGARRGYAVAAPAVGSYHQVDGQPTLNSPSELARRISAKVLPKLEKPDVKKVLVVGSGGLSIGQAGEFDYSGSQAIKALRESNVETILINPNIATIQTSHHLASEIYFLPVTADYVAMLRSFSLASRAAAARRSVDGQPTLNSPSELARRISAKVLPKLEKPDVKKVLVVGSGGLSIGQAGEFDYSGSQAIKALRESNVETILINPNIATIQTSHHLASEIYFLPVTADYVAYVLEKERPDGILLTFGGQSALNVGIQLDKMGVLERLGVQVLGTPIRTLEVSEDRDLFVQALNEIDIPAAQSTAVSTIQDALDAAATIGYPIILRSAFSLGGLGSGFAHNEEELRNLAAKSLSLSPQVLIEKSLKGWKEVEYEVVRDAADNTIICCNMENFDPLGTHTGDSIVVAPSQTLTDDEYHMLRSAAIKIVRHVGVVGECNVQYALDPVSRDYRVIEMNARLSRSSALASKATGYPLAYTAAKIALGHTLPELPNAVTKSTTACFEPSLDYIVTKIPKWDLAKFQHVERNVGSAMKSVGEVMAIGRTFEESLQKAIRQVDPNFAGFEAYWKPEDMVTALTNNNDRRLFAIAHAMLNLDYTVDYLHDLTKIDKWFLYKLENIVNVYKQLKNTPFEKLDKELVMTAKKTGFSDLHMAQLLGKKEGDVRALRKQFGVTPFVKRIDTLAAEFPAYTNYLYTSYNATTHDVEFDEHGTMVLGSGVYRIGSSVEFDWCAVTCSRAIRGMGKKTIMVNYNPETVSTDFDEADRLYFEELGFERVMDIYEAEGAQGVVVSVGGQLPQNIALRLKNSGVDVLGTDPEQIDNAEDRHKFSSILDSIGVDQPAWTEAASLDAAKEFANRVGYPVLIRPSYVLSGAAMNVVWDESQLQHNLSAAANVSPDHPVVITQFIDNAQEIDVDAVAHKGKLLCHAISEHVENAGVHSGDATLVLPPFSLSQEDMARLKVIAEKVAKAWDISGPFNMQIIRKPPTEGEEAELKVIECNLRASRSFPFVSKVLGHNFIDTASAAIMDHNVPEPVDLMAQKRDYVAIKVPQFSWTRLPGADPFLGVEMASTGEVASFGKDVYDAYWAALMSVNGFKLPKEGSGILLGGDVSRPEMAAVAKNLIDLGFSLYTYDPKVEQHINSQPYLSIKKILVPVKDKKKLREILEEHEIQTVINMARSRAATTLDEDYASRRAAVDFGIPLINNPKLAVLFTETLAKKFGKATNPIPYQEGFKPSEVGSWRDFVGPASDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V328</accession>
    <name>K1V328_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V328"/>
    <dbReference type="FunCoup" id="K1V328">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V328"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="InParanoid" id="K1V328"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002806">
        <property type="entry name" value="PRK02948.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="77"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="482" mass="51830" checksum="BC80676374FD18BE" modified="2012-11-28" version="1">MHAVRAARQPLRLALATPLRASVARAASVPAVRGLATPTSKVGANVSDAPVAEAEQAELPGFKLAPAKSTAMTGRPIYLDMQATTPMDPRVLDKMMPLFTEMYGNPHSRTHAYGWEAEGLVEEAREHVANLIGAGPKDVVFTSGATESNNMIVKGIANFHKGKKKHIITTQTEHKCVLDSCRFLQTQGFEVTYLPVGPTGLISLEDLKAALRPDTSLVSIMAVNNEIGVIQPLAEISQVLKDYAKENKVTKALFHTDAAQAVGKIPIDVEAMGIDAMSISGHKIYGPKGVGAAYVRRRPRVRLEPLIHGGGQERGLRSGTVPAPIVVGLGEAARLCSQEMSADHAHISKLSQRLIDGITKDVEHVVRNGDPKHGYPGCVNLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRALGASDDMAHSSLRFGIGRFTTEAEIDMVVNRIVQVVTKLRDMSPLWEMVQEGIDLNSVKWSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4A5</accession>
    <name>K1V4A5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4A5"/>
    <dbReference type="FunCoup" id="K1V4A5">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V4A5"/>
    <dbReference type="eggNOG" id="KOG2973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037769_2_0_1"/>
    <dbReference type="InParanoid" id="K1V4A5"/>
    <dbReference type="OMA" id="NCNFLAS"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="143"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="360"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="461" mass="50949" checksum="FAA997AD4C0A862F" modified="2012-11-28" version="1">MSELTQLFEFLSSPNPAARQIALKNLIGHTPKNDPQRDIFIPSSFAPAPGEKGGADGGGLLPNKRKEGSEQDEVKIKAIQDLANLCRDQAAIAHDALSALINLTDNLAVSRQLMQPEFLVWLVSYTAIANLQIPVVSMPKSKNYPPYYLPACASSSSTIHPDFRDPAFVPPNAEVGQEPERDIEGLRALVAAFEDGASEGVKEGKGKRKGDVNFLASVFANISMLPATRDLLLTPQPAFPAPSSERTDDDEPLLAKIVVYTEHPDTIRRGGALGTIKNCAMERGTHPWLLATEDERVKLPTSDKTVRGVDVLPYVLAPLMGPEEYDMDEMEQLPDTLQFLGADKKREQDPVLRMMCVEILLLLATSYTGRETLRQRGAYYVVREAHKAESDQNIKEAIERLVSLIQGEEGRETRQDTIDDIVKKVQEPTGAVPPTEAAEDLRKEEREERKEDDDDMDVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6Q2</accession>
    <name>K1V6Q2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6Q2"/>
    <dbReference type="STRING" id="1220162.K1V6Q2"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340154_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6Q2"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="835" mass="90301" checksum="4BF9026130ACA4F2" modified="2012-11-28" version="1">MPIHTIAEKLSHVDTKKLSTAVAVGVGALALKVYSGGKKSVWEREWGGKLIIIALAASGNPLAQLNCEPLPPTPEAVRDFVKKWTSTPAGTTGEGGRRVDAIVLGGNWECGIYDQWSAWDPSTHPGVSWTPQQMHFHLITSLLPHLMKAPAERNIRIIELVSPGWSSALPGVEATMKGKRPEPDEGVLADAGKRAIVSLLAQERLALVLNTLASAEYSKREVVPDPNAPSTKKRDTSVQSNILALSVIMPWARDEVVHPIWGEDSLFKWFALYPLVLLFTPSPAQSVQPILFALNAPVAYINDASADYTGNTDKSASDNLGNEEVDGSQRPKDLSKKDAPLPESQRSVRQGSVIRDCQTIELPPVLRDEKLSRATYDRIEEEVMKGVTETEAKEGNRGQASKPKGAKGATAEKQASTPLKTGAAPPKRKEETVTLDVAGGVPGQQPSQAEKAAVDGMKAQAKAQEIGDKIDVAASREEQHVAQPEASAKEKADEIANDTTSTADKISQKVDDVKEQADKKAAEVKQQVDQKAGELKQQVDQKAGDAKQKAGQTDKAVKNDAADKKAKAENDEKNLEKKVQEKAKELDVPPPETKEQTKERVEKIKENEPKKGESFADAIKEGTHEDHHKQQQQKSAQPTQAQQGTATQHTGTHDAHVHKGESFADAIREHTGAAHPAQQAQAKSGTQHTGTHDAHVHKGESFADAIKEHAGQHQNASAQHAPAQHQQAPQHAQQKPAAAHDAHVHKGESFADAIKEHNAHAGAQHNGSQHTQQHQAQHPQQTHAQPQHQAQHKQQVQHESEPPVVNPPVQTHVPQGQGKVHAGESFAAALKEHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8N7</accession>
    <name>K1V8N7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8N7"/>
    <dbReference type="eggNOG" id="ENOG502T2A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2110667_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8N7"/>
    <dbReference type="OrthoDB" id="2553859at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12485" checksum="68E2BDD47032BEB0" modified="2012-11-28" version="1">MPSISFSYAVAPPEGITCSTPATKSESVDFTPGKSDRSATNAYYEAATPALREAQLRLNELLTEWKDAVGDAEKQKEDRGKVAYGKGKAARLMEMAKKDEASDDSEDEDDEDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA46</accession>
    <name>K1VA46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AT hook motif family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA46"/>
    <dbReference type="STRING" id="1220162.K1VA46"/>
    <dbReference type="eggNOG" id="ENOG502SITF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1112004_0_0_1"/>
    <dbReference type="InParanoid" id="K1VA46"/>
    <dbReference type="OrthoDB" id="4630416at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="256" mass="28153" checksum="7EDB6D51F7CDDC9D" modified="2012-11-28" version="1">MPVEHDFEDDVFSASDDDDSDVEDSVMKERSAKHAEYCARVKKSTTIAGTYVIDCPEIENGWDDVSDLQLSIASTPLAGFYQATFNFGIYEGVMMLSADRKALSYFSEEKLRDLETADEVAKADQKQSVNGHHERKDNDGISLGTKRKADDAEDRRPSKAAKTESAPESSASAPLSLYLCMRTCETGTGEIDPDPSMGRITFNDALTTFTGTADIGCVGRNVPLRGRKISDNVENQARWEDYGHAAAEAACNSRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBE0</accession>
    <name>K1VBE0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBE0"/>
    <dbReference type="STRING" id="1220162.K1VBE0"/>
    <dbReference type="eggNOG" id="KOG4182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006044_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBE0"/>
    <dbReference type="OMA" id="LKYYHNC"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="932"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="932"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="956" mass="105273" checksum="E34423BBFEC13FCC" modified="2012-11-28" version="1">MALPATLAHTTWTEARWHDDDRAAAGDHKSLHYTKTPARRVNSLNMAETGAKGGANDNHLKVDTRTPPDLTPDVELDEVVDPLSSLPALASALDSAYDDVPGFINSLLSDYVPPALPSPAPQQPPNLPPIEKQLNELMTRLSLLNQDTSSALEQSISDISRTVPRLTYDLQFMRESAVSLQSSLRRVQDKAARQQLGNDSEEARTQRHLDKLTHLDKLKTRMEAARDILAEAESWSTLESEITTFIAEREWTKAGERLAEASKSLVVFQSTEGEYESKRSLLVSLQNELETALSAALRDAIAQVDTATTAQFHEIFRMMEREHEFRNYYFAARRAPILEAWTNVVLLDAGSEGAGEGAEEGTEPVKFSSFLPKFYETIIQTLNSERTQIPLVFQTDSAANILSSFFETTLDALSPSFHNRLSAVADHYGPEALPEVIRAFTATEELGVQIQGLMDKLAFNTQGGHVSGASLSQSPSTATNTPVSPSMRSRRSTNPNRMSMSHRFSRSVSFLEAAPASPTAWETTIYEPFLDLQSSYPALEKRYLRHLLKHDPALTRPANRDNPARTLNERAAVVFGFAEDAIGRCVAFTHGYGTRGLIDALNDLVRAFLENNGDILDSAKRVSNGTGDGKDDLGLEGLDYSTEDWGAFQVALHVLEACRGIRDKLSQFETKLYQALTDVAPRLIISAADPASFTLKDTTLGALTLLQQSTLNSVELHSLIGSLPGKEPPAVELTKARDAVSNFTRSAQVFLQSIILSPLRSQLDTYPSLSVWEKPDKEKKRGDLHVPTFSLSPTDTMARVAEGLLNLLRVFEEYAADESLAFSIETLPFVDVDSLRELLAKPSDVLDPQAEKEEPTLGAEAVLSTWVSSLALSLLSSLTKTTLHKIPALSNSGSAQLASDLAYLSNAVRALDVEWEDLEKWREAAEATPEEWREKVGNDRKGPWGTVGRLRGFTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBP3</accession>
    <name>K1VBP3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxisomal 3,2-trans-enoyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBP3"/>
    <dbReference type="STRING" id="1220162.K1VBP3"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="InParanoid" id="K1VBP3"/>
    <dbReference type="OMA" id="IKWAAND"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="30007" checksum="2BA4AEDCB668C28F" modified="2012-11-28" version="1">MAPLPELTEVVPVVHPHGVLELRLNTPKNLNAFGGEKYLELIEGFNWARDNDDIKAVVVTSTGRFFSAGAAIGAGGMGGDGPKTPRTESPATKYIAMLIDFPKLAVCALQGPAYGIAVTTLPLFDLVYAVENVTLTTPFSRLGISLEGCSSVTFPPLFGNSLTTRLLYLAETVPMDDLRHTGLFAGILDPNAFQETVIKKVQDYLEDLAFGSIVVSKAQIRTPEQRKYLHKVNIDEMAAVDERHRSQEHKDAIKRFQEKAKAKAAAKKAGQAQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBZ8</accession>
    <name>K1VBZ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBZ8"/>
    <dbReference type="eggNOG" id="ENOG502S33V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242744_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBZ8"/>
    <dbReference type="OMA" id="PRDHHIS"/>
    <dbReference type="OrthoDB" id="3013446at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1643" mass="173769" checksum="0C9984EB189F59D6" modified="2012-11-28" version="1">MNGAGELARASRASAAVHTDAATSPAQPPSSIPLPHHPPDQVTPTHIPPPPRDHHISTSTLPDTAASATSISSPSADTPADVDVPSASVPASLASVALPDDSPTLVTSASAPVPLAVPSVPPVPSPSVPSLLASQDTGTSSSNSPTTSTTTQPRQSAFQYPTFHLDSFKSLSYESFTNQSSASASTGPSTSDIATPPTSASLIPPRLPIRSPSPTSSSALKQPQATDVPRPSKSGQDISDHRESQHDAQERAPEDSAPTTATNTPLLSTPGLLDSLPIRRTSLVGPPSPSWPSVQEPVQRQSVSSATAPPPSDLGYLVDAVPDIEQKEQQSSLTTSPSTTTRPLTIVTDADKTPVVPSSPASRASGASGGASAFTDSHLAWPQVPRPPSAALSARDSLSAGASGSVRDVHADSPLTPTNAQFEFPPPRLVESPTVPRRRTLIAASPTPSAVQLELQQSPTAPPPTTLPTSPPAPDLRLQPQSPPPQQHLHPERRSSLLPPAKRASFCSTTSSALEAAAADASSLAPPIDLSSPSNSTPKRTSTSTISAGDARPGSLTPRGRALLPTSPQSPNSSSDPSRKSVQMTMPMPMPMPVPTSDPSRRSSTHHPTSPSKNGAGLGIQSYEPAAIRQVRTRSPDRSSARYQTSPVPSGKQFDMPTPNVRKSVSVPPPSGFQPSHQPAKSASNLPAIAGLADAGPYPTPVNNNAPLAKGSGGGGFALPGDVSGQPAPQKPIKPNEEICLECMMRDRDLADVDVSGPGCWDRESNAAFEVLKERETEVLRTMAQEDALSRASFEASTCTGESASTPRSHASAPAPDDTSRSADEKRKQLKEARRARRAERDAQVARVGWRGFKWEEGPNGEGFPKGFAGTRPGALTEKGIKNVMQMILQNYLRGQYRLILEVRQEAQRIGHYTEPEDPHYPNSQETHESSLDPSSTISRHKMRNQSIDQGAPSIKAPSVSTARSVPILSSQVPMLRQSPSTPAGLSNVSVQARRPRTQYVPDREPGINGASLSAQTSRQTLSINTPTQRPSSHFKAPSSTSVPKARGSQYYTDDWSDTEDLWAPSSPASGNLRPFSFAVRAGAGGGQGSDGGHSRKSFFGRFGGSVTSLFTGAGSHGGSGSMMDMHLGLESDRRNRTSSYQAHEQPRVLPGMAPGRPSFQGGRNSVATSMYLGNGGARSSDDVMLRERRAHSTSASRLTQVSMYGDDFDRSSATTEKKKGFKGLIQKMKKGKKDPSRRGTEELAPPPPMGFLVNRQDGKHNRNRSGSSSSFVEAPSPVPQQQMQMPRGSINGPMTAPSSGSDVSPTSSRFGPDGRQRTNPVPELPPGAESAGYPGATMEMLAHLPGNSPVQATHSQQQLEAPTFTDEPQAMNRDPFARSAETASDGNRSPSLYTVQGGSRKSMQPSVSSRLSTSTTMQGLETPDGQPYMNGSYSQQPPSQQSLSPNRHKNLPPLPPGMATPEMYSSHQDDGASISIRTSLFDPKRMSSMDQGRALCPPSSDYFPTASPRYHQAPMPNGAVQSSPSSTGSSVMPPQANLPLPRRPIQPRASFDVLSDARARIRRSTAESGRLPMEDMGGRNAQSMYIQQPAAASTGSFGRFISREAPLGPKGGLVVPTLREPYGEERKERRRGIKSIFSSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDJ0</accession>
    <name>K1VDJ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000301">
        <property type="protein sequence ID" value="EKD02050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDJ0"/>
    <dbReference type="eggNOG" id="ENOG502RJJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014655_1_0_1"/>
    <dbReference type="InParanoid" id="K1VDJ0"/>
    <dbReference type="OMA" id="ENAGWRN"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:linear primary-alkylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.30:FF:000001">
        <property type="entry name" value="Alkyl/aryl-sulfatase BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="entry name" value="Alkyl sulfatase, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.30">
        <property type="entry name" value="Metallo-beta-lactamase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052195">
        <property type="entry name" value="Bact_Alkyl/Aryl-Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223">
        <property type="entry name" value="ALKYL/ARYL-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223:SF1">
        <property type="entry name" value="ALKYL_ARYL-SULFATASE BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="612" mass="67447" checksum="A6D420759E7DE8E6" modified="2012-11-28" version="1">MAKPATDIIVKQQEEAKRSLPFADTQDFADATRNLIAPLKPVDARVWDVNWYDFLNGDAPDTANPSLWRQCQLANIGGLFQVAEGIYQVRGLDISNTTFIEGDEGVIVIDPLKSRETGAAALQLYRDHRGPRQIKAVIYTHPHVDHFGGVKGMVTQEDVDAGLPIIAPVGFLEHAVSENVFAGTAMGRRAAYMYGAIPRGPQGQIGCGLGQAVSRGEVTLIAPTDSIETTGETRTIDGVTMEFQMAPDTEAPCELLIYFPRQRALCAAEDATHTFHNLGTLRGALVRDAHGWAKYLTEAIDLFANRTDVVFASHHWPTWGATSVRRFLSVQRDLYAYVHDQTLRMLNQGYTGPEIAEKMRLPPALETWSTRGYYGSLSHNVKAIYQRYMGWFDGNPAHLWEHTPEERSKRYVDLIGVDKAVAAGEAAFKEGDYRWAAEILNHVVFADPSNPARELLADTYEQLGYGAENATWRNFYLSGAAELRSGKFGAATAASPDVISQLTPEMLFDALAIQINGPAAWDVQFSMDVVTDTTYRVWLSNGALLYTKAPQTNDADVRITATNRSLTAVAIYGLDPEQLEKAGIVLEGDIGALRRLRALLDPGDRNFNIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDW6</accession>
    <name>K1VDW6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03512</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDW6"/>
    <dbReference type="STRING" id="1220162.K1VDW6"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263756_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDW6"/>
    <dbReference type="OMA" id="WDERPRE"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AreA_GATA"/>
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        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
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        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
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            <end position="231"/>
        </location>
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            <end position="272"/>
        </location>
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            <end position="491"/>
        </location>
    </feature>
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        <location>
            <begin position="516"/>
            <end position="622"/>
        </location>
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        <location>
            <begin position="663"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="840"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="959"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1059"/>
            <end position="1096"/>
        </location>
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        <location>
            <begin position="1108"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1193"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="184"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="262"/>
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        </location>
    </feature>
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        <location>
            <begin position="316"/>
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    </feature>
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        <location>
            <begin position="378"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="435"/>
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        </location>
    </feature>
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        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="518"/>
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        <location>
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        </location>
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        <location>
            <begin position="603"/>
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        </location>
    </feature>
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        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
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        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1273" mass="136691" checksum="C5CE01B7114B28A6" modified="2012-11-28" version="1">MTVKPWRTSSGGGSKKGRFTVDGGGTMSPQATAIPTNINGNRSNNSSQFAASPSQSQQQGWPLQQQQRYDSFASADSFLADMTSPSDVASVLGTSANSFTPNAQSFAAQYAAARQHRGSVPNNDTPQSPWPLNGDQQPQFEVPGLDQNWNTQQRQTENLNPTSNASSYDGDHNLLANLAELLNQQQQQQHQHQQQQQQRQQQQQNQRRLQQQAQQQQQQQQANNLAGNSPLPMNLVAALTMAMQATQQQQNHPSPQQPSAPSPMQQPMLQAAASQSLAQLLIQAQQTQQQQQQQAKQAQEQAQQAQQLIMQLLQGQLAPPAQSPQSSSSQQQQQQQQATSLLTRRLQQQAGDSQQQRQSRDSAGFAVPPPRTTGPMPAQNQFSSRKQSNVGHSWQDRETPAGTPAGSSDAASPAADSSSVSSKFRPIKPRRAEAPQPPAPPTPSPRTADKYSASTQMPASRQTSKDSETPWSPAPHVDLASLPPLPPGLTMDHLSQYGDNALEMAIRMGMGIGMSLGQQQQQAQSPQVQQPLLMSGSSGKPVTPKASGPSSPDTTGSRQRSNDVVTEILADDFFSSRSPLSTSPQSAGLPFLSPGLGGRRPSGDPSGPASPSALDLLAPEQMAQKDPLATQVWKAYARAKYTLPHASRMENLTWRMMHLTMKKPDDKSDTKDKQQAQGDAQFATAPTHQQPPPLQLSQASEREPGLPQPPGSAEEESERGRRKGKSRVVGFSAANRDSSLLASGGPASNASASMNPSPASLLPFARSMPNNYPPWAAPGAEMAMSQPLSKDYNMEQFANGKDPKNTIAFSAANSIPEVNEDVLSSSAPDVEFARQLHNHLSAQQQQQLHQQLSDAGSTGESKDQYIAQLPGISGPGLYQPTPDNFHPQYGFLPRRPARKTSFDHTVRPNLDGSGTITSRKRPAEGSPRDGSHLPLPDGTSAAFPSTDFTFNYDGYNNFFDLNNGPPENGGEPSGPPQLTTTEWPATENSEGSDPAANAFDMSTLFPNTIQPQLAVQQNSEAPFDFQQLMHIYLGEGNATPFTHINPSDVLGSVPASTAVSEYTPAQSPQAPQQQQQNGEHMQQRISGPPLRSNSSPNLAALRMQPITPAAPAGTSRGHSRQSSSAAKGGKRSGNATPVEGDGENPTMCTNCQTTNTPLWRRDPEGQPLCNACGLFYKLHGVVRPLSLKTDVIKKRNRAAPTKESSSGRKGRGRNSKASSPQAQRTAGPSAAIPKRQRRADDSDDEDDEPDSGTASLSSSYAGGGGMLSMTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDZ7</accession>
    <name>K1VDZ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paternally expressed 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDZ7"/>
    <dbReference type="STRING" id="1220162.K1VDZ7"/>
    <dbReference type="eggNOG" id="ENOG502SC07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594731_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDZ7"/>
    <dbReference type="OrthoDB" id="5599419at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="460" mass="50380" checksum="FA7216DEA7354DB1" modified="2012-11-28" version="1">MWLDNQVAGHFGKVVSRIDIESPDSVTLQPLSTHPLSISDSEPEFDSEHVHYSLSTITEKPTSDKPISPTPTVHISRPKPSVTATRTTGRELVEKQLKPRTFLVTLDVTVFAPPIKPDGQLDHDGPHEVIEAVALIDSGCTDNLISRRLVDSRSIPIRPMGQPKYPKLADGTRSSTPINEETAALRVRIGDHEEPLAFNVAPLPDYDIFLGAPWLSLHNPTINWTEGRITFDSEFCTEQCVPDKRMTQLPTSVQPQILKSCVAKLHFPSKSPDGKPLPRLKKMKPPKEVAQEIMALCATFLTSSDSPDSGQPDSSPLSPSTTATTTMPPSSTCCPDPVPPSESPPVKTPTYTVSPGTDMGDTCIGPSGEQSSFNVLFDDEDDMTPTQYLLHLAEVVDEAETIFDALSGDLDPLFYSYVDPAYPPEPPDKDVLKTQVPAEFHDFLDVFSKTLSTKLPDHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEU1</accession>
    <name>K1VEU1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEU1"/>
    <dbReference type="STRING" id="1220162.K1VEU1"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="K1VEU1"/>
    <dbReference type="OMA" id="IYLFMVI"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="73"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="506" mass="54990" checksum="F7641406D0FE4731" modified="2012-11-28" version="1">MSAPQAPLNAAPLTTSPAPSHDDIDKASVKHLDTAPEHAFEGEDERAVALRLARAADPGPPLFSPRGMQFVLCALVVCACSGDTGFDGTIMGAVNSMDQFHTFFGFDPQTGADKTGIVFGIYTVGQVCAFFPCVYFPDKIGRRYTMFGANLLLIAGALIAGFSRNMSMFLFGRFLVGVGCTTAGLAAKTYLSEVTSPWNRGRWMGLLNSFYYSKLSFPPREQADATVGQILASGVSIPLGRLTSNYSWRIPLILQCALGVINVAFVLFPPESPRWLYAKGNGQEAVRLLAHLHSRDNDVDSPLVRLELAEIEESISLQGADKRWWDFRPVFKTRAARYRFGLGLIVAVWGQLSGNGLITYFLPMLLKAAGITSPDRQRVLNFVNSVTSFAGALLGTSMVDYMGRRFLMLFAEISCACGMFIVAGLLSDAGPQNQTRANAGISFISYLIFGCFDVIGVVVIWLFVVETKQLSLEELDDVFASGSPKAMAAALHRRAKKAAKERQHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEZ3</accession>
    <name>K1VEZ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GFO/IDH/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEZ3"/>
    <dbReference type="FunCoup" id="K1VEZ3">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEZ3"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_19_1_1"/>
    <dbReference type="InParanoid" id="K1VEZ3"/>
    <dbReference type="OMA" id="RFERWRP"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="133"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="356" mass="39299" checksum="41DD5F06B4B5027C" modified="2012-11-28" version="1">MAPIRVSILGTGLSLQAFHFPLIDALPDKYILHSVMERTDRGKARAVCGPDTKVVNTIDQVVNDPDVDLAALEAGKNGELTTPGRPLTPVMVEKPVTPTVKEAEELAALAKSKNLVFCAYQNRRWDADFLTLKDLLKSGKLGPIHEMTSRFDRYRPLPPGHKSSSWKETPGQHNEGIYNLGSHVIDQALNLFGVPEKVWCRNYDERGVGLDECFEMELLYPPQPGATGPLAVHLGANMLNSVPVQLRYLVKGLKGSFLKNGLDPQEPFLRAGKKVRDEGFGIESEDAWGTVSTVPSKNGWYPAIYENVYDAITSKDPSKLVVQPEQAIWTMKIIELGNKSSKEGRVIDVKAEADKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF25</accession>
    <name>K1VF25_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosducin thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF25"/>
    <dbReference type="HOGENOM" id="CLU_883352_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF25"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34926" checksum="534E8810A089B75F" modified="2012-11-28" version="1">MFQPSASLLSLGKAKSSSSPYSSNTGPKGVLSDSRQANAEERDARQAAVRRTRAEQEARAITALGPDEGTLRIREGPIGMYPTSAASWTMSPYHGRGFRSGSPASSSKLYTPQPQQFWALLRAMMGRENRGAARPSSELYPRQQGADEVFDLDLSKLDLSRLDLSALDLSEDELALLLQLRDEQAASKAGGREEDVERDELREWRERRRAEIAEGRVRDIDTEEFLDIIEEHAAILIYEEASSILRRHPDTPPLVKITATALQFMTTEEGPDEAVLPAVLVYRRGDLMAKHIRFEGDLETLLRSNLAAVEGADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF63</accession>
    <name>K1VF63_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF63"/>
    <dbReference type="STRING" id="1220162.K1VF63"/>
    <dbReference type="eggNOG" id="ENOG502S9NZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516989_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF63"/>
    <dbReference type="OMA" id="ANQQYQP"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="417"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="528" mass="51925" checksum="5678417D80385844" modified="2012-11-28" version="1">MAAPPSSSGMGTGLTADGAGTEGSSAPSLTSQQGSGSDAVDVSTTSQSTVEPSSSSVQPTSSNDPTTSSAEPTTSAQPTSSSTTSSSAAPSSSSTQPPSSNEPEPTSSSTSSAAPPSSTSSAEPSSSAEPSSSAEPSSSAAPSSTESSAAPSSSSSSSAADSSSSTNSVPSSVDGGPLTSTTLVDVPGLQSASPRPNTSATGAAGLQSNNGGGSSGLSGGAIAGIVIGCVAGVALIALIATSFLRRRSRQRRTLNAQSMFEPWQTAPAVDDMPYEKSFPMQEQPSFPPDTGADTTGAYYNGGADPNYANYGQFDASGSPYPQFPYTDNAVAGGMAGAGAGGMAGAGAGAAYAGYNADGTPMGEVPHQQPLMDNGVGAAGVGAAALGGAAAAGAAGAAAAGGNQRQSMVGVPAPAGLHDNMQVNVKVGFVRSLEDELAITQGQNLFLHQTYDDGWCLCEDEAGNRGVVPLSCLEPAEGAAPQAHLWVAARRAQRAQWWHLDRDQTAGCQLISGMSFGAGRTDTTLNLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFB5</accession>
    <name>K1VFB5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFB5"/>
    <dbReference type="HOGENOM" id="CLU_576446_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFB5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="433" mass="47280" checksum="BBFCE5FB08D9985B" modified="2012-11-28" version="1">MNAPGSSATASAASLGQSATGAEEESLRLLLNLTSLSVDTFTSIVHSQADTSLNFFARYILGDATRVARILKGNPSPVNDQLVQTISNELETPRANGLNDIPDTLPLLWPVVAEKVGSVKSCLSSTLGRETTDDAILALIYGEPLTTRTTQLDAIRAQQGWANAPDEEISAASRLARLALLTTLGLCDQTHVQSEAGPLATLANLIDQPICERKHVLDNEAPGPLRMVHVFFSARFRCTDWEQGKGQPPFNCTAPCAHNKALHAWYKYDIDLAQKLFAAECKKRDLTEEEGWRVVRLSYLPWLRINERVVDPRPVGKSPEVITMDFMLSLVSALRRAGRGLGEAEAIWEELVQVLDGSSTLTVFQIDGEGETEETLGDIGTNSWADEFSDELQKLIKGKEASGGLLNPVEVDAFFPHHCLKAIIDRVNAHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFG0</accession>
    <name>K1VFG0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFG0"/>
    <dbReference type="FunCoup" id="K1VFG0">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFG0"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014293_1_1_1"/>
    <dbReference type="InParanoid" id="K1VFG0"/>
    <dbReference type="OMA" id="GPHIFMC"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="220"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="528"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="634" mass="69602" checksum="FA9ED61C70A7E2B8" modified="2012-11-28" version="1">MAATNVLSRPISVYSIPPPLLDALTVRSIQAQTLSQQTHNDAQQIEPVPEQEPTTTASTGLGCQTCPGASFDTPDDQRAHFKSDWHRYNAKAKVGGQKIVTADEWENMVEGDISGSASSASTSSSRSRITKLLKKTQIKDNDKNDVDSDEEAEIAELQRRAQLRTAVIWFTAPDAPPSLSVPTNTQFGVHRALLPSFQTAGDYLSELKRLQLAPPTPDEEERRITLLMVAGGHFAGMVISLRPKGKNEPQAVKGAGEVRVLKHKTFHRYTSGSQGLNDNAKSKAVSAGAMLRRYGEQALQDEIRELLSEWEEDLNLSERIFIRASTHGKKSFWGYDGAVLDKSDDRIRSFPFPTRRPTQQELLRCWHELTKLKISHLSEEALQAQDDAYMASLQPKKQAVAAKPAAPAPAPVPAAPKLSPEEEAKLDRQRRLADMIKKGRLDALRSFVEKYRSEITPAALGQAAADGQEDIVRYLLTDGKLDPAAPIDGNKRAYDMAQTKGVRNVFRRVAYDNPTMWDWQGAHVPSGLSEEAAAEQGAKKAERRRGLRDKMREKEKARAEAAAEEEEREKAEAAAQAAAQPKGAFGGLGLPSAGPQKLGGRGAEGGLAGLSPEMRMQIERERRARAAEARFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFT3</accession>
    <name>K1VFT3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFT3"/>
    <dbReference type="HOGENOM" id="CLU_804566_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFT3"/>
    <dbReference type="OrthoDB" id="2597004at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="36982" checksum="87054C3A3FDB7191" modified="2012-11-28" version="1">MVISVERHKLITERFGEQRPSAAGRLPASVASKLTAAKIPYSSYPHVIETILAFSDYPTLLLFRATSSDIKAKADRALCDGKLKVELRRTSRDSHVQQATSNGSSRSSDLEVVLRSGHGVLPFLGQEERKLAFSLSHTVDIDGACFSFPATAGLLSPPELDSLFHPLQASLRRAMQSLPRSAKVIIAHEPDHGPPLFLPPADHLIFTCDAHCECRQFYRGPSHSASHITLRMTAELQPSSSRPRLANYCQLIVLALEPSVQRLTMSADLGDDIVSALVFHRGERMDFTQSDRNKPNENLDLEIRLKQPGNFPAWASHFGFAPNQVHGMLVSDDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGG4</accession>
    <name>K1VGG4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGG4"/>
    <dbReference type="FunCoup" id="K1VGG4">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGG4"/>
    <dbReference type="eggNOG" id="KOG3566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007442_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGG4"/>
    <dbReference type="OMA" id="NIEYNMV"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="515" mass="56738" checksum="9708011A888F6DED" modified="2012-11-28" version="1">MEVEERESVRLEYTAGQAAAAKKRRRQDLVIDFLWNNLGYVRLVLLVVALAWIAAIPHPRLWKGIFVDEHALIPAGQRSYYDWGNVHKADNYLAQLEELQARNASWDERRDYLMHEFRAAGADAYNTSHSVYGRIVPPRAEGTEAILLTANWDSRDGGPNLRGVASLLSLVDFFRGQNHWAFEIIPVVGDGYLYGLEDFLKNYKLRANVWNALNLDYPGHSFERLGFFYEGVNGRLPNLDVLSTVSTVARWKGGCPVTLHDAPAYPARIYTNGLKHLWRHFSYAALGRPSAAGGLLARHRIDALTLYGPPAEGPHGFHTLGMVVESTFRSFNTLLERLHASFFFYLIPHPENFIPVGHYLPAAVLLGASITLGGFVCPAPLAGTFWALVPIALGVIGWILQTPYVALAAPLLPRPRGAARRSFNSLAHLAYGAMVPTLAMVNFPQAILLGLLSVVALAPVSRFIKIALVPVAIGALAGLKAAGIDLRGEWELYGNLAWPALFAVIIPLIAVSVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGG5</accession>
    <name>K1VGG5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGG5"/>
    <dbReference type="STRING" id="1220162.K1VGG5"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877699_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGG5"/>
    <dbReference type="OMA" id="WPLEDEF"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36354" checksum="74D2BA26A9094347" modified="2012-11-28" version="1">MDAIPNGVAASLSSGRSTPSHIGTGVHILAGPSQPPSNLASGASSLNESYDYDYDLRPIPSSILDSLPAESRQLTSRYPGARQAAVLIALYQREGEDGLRVLLTTRAAHLRRNPGQTRREAHEEIGLPPRSEDVYNVAVLEPIVTVMPVGAMWKHHIIVTRESVLSPPSALPQRNGQLPDNPPRANIPAVVAYIADPQILEDLTPNPDEVECIFDHPFGAIHRGSVAGDAVSDLVPLGSDWWPLEDEFHGFTSDVLISATTVAYSREPEYGHMAAEQLSFAETIREVLLRLASEGEEPEREIEWKATQRQQSEMARVKARVKQEAEGRCEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGK6</accession>
    <name>K1VGK6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lon domain protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGK6"/>
    <dbReference type="STRING" id="1220162.K1VGK6"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057571_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGK6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000010">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="5">
        <location>
            <begin position="117"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="352" mass="37550" checksum="CA6A2A600678A1B2" modified="2012-11-28" version="1">MVILGSAVVGPCSLRRTETDESEVEDPGRSVMGATLAQHRSLSSSNSSAVEEVVEEVKESEKRGDESKAKSTTAAPTDSSSKDAASGSSGSSSGPSSPGPKGKEIAKPSIPESYPQVLALPITRRPLFPGFYKAVTITSPPVIKAIRELIAHGQPYIGAFLLKDSESDSDVITDLDQVHPVGVFAQITSVFSSADQKHQQPAEGEEGEPRPETLTAVLYPHRRIRIDELVSPMTDQPPAPEPAVAPETATETAAEEKKDEPSAAETIEPSKSEDDVASFEKEIPSVEETREALADAKETKETKEDETETVEAEKPSGSQIGFLHPLLPEISLTNVSNLNLQPFKKDSQVGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGP3</accession>
    <name>K1VGP3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGP3"/>
    <dbReference type="STRING" id="1220162.K1VGP3"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002125_3_0_1"/>
    <dbReference type="InParanoid" id="K1VGP3"/>
    <dbReference type="OMA" id="WDSDRNT"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="557"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="751"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="785"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1159"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1159"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1185" mass="131722" checksum="0A98D19D826E211B" modified="2012-11-28" version="1">MSTTTNGTPTVTKTTKASPSKSGKRDTDFPALPPAPAPHVFGTGYSGKHKVPKAQDWQQINERHQQQADEYARIMEMREQAQQDEDRLAEEGPTSEEEGEPAYVQVDGDGDPVNPQDSPTTAGNKVSNDGTQSRKKADPKNAANEKQRLMNQMTSFTGKLSSPGQADSVQRNRPTASRRLRRESAEFVTPSRAESSWSRTQTRKTQAQAASGEDHCLPHAPPRALARGARAGSARAPQARRWSPSRPALLWLLPSSGLPLVLTTDFEPSRTRISGGNVTYYPFPPPAPSSVNDLLKRCQQLQYLIIGSCLVLWFFVAFGNGIMTALWRTFLLMLVGIGLYAATGLLLKNLEKEVDAIRLDLTRARGQAFSPPYPESAEWLNGLIELVWGGRNPMKLSSVRALPDQPGDDGYPKTNWIDEGTDTPSKDMDGDVLKEDQAGDYYNFEVAFQYSAQPGQNDRDKNIHLLIEFFLGTHDWFHIPFPIWIQIEQIYGIARVRLQFIPEPPFVRNCTFALCGVPSVEVSAIPMSRHLPNVLDLPVISGFVKEAIAAGTSELCVPKSMTINLKDMLSGAAVGDTRAIGVFIITVHYCEGLSAQDNNGKSDPYIVLAYAKYGRPLYSTRIIIEDLNPVYEETAALQLTEDEIRSDEDLASRTDASDLVGRVQIPVKDLIKHPNKMFDRTDGLMGFEDGNDMPGTITWSIGFFDKVPLKKANERLPTAKEAKSDPGQKSAARSEMLPGDKGPNPARDYPPPPPPDVSKTRPDDAWPSGVLSIILHQVNNLERQQLEGKSGQDREGEAGQDTDDPSEQTKNLPCGYGEFIVNDELCYKTRVKQYTTNPYFDAGTEIFIRDYTTTEVRVVIRDSRLRESDPIMGVVSVNLNDVFCEASSVTATYPIQEGVGFGKANISFAFRSMRTKLPVNMRGWNTGTVAVQDIVLRADPSKKDKFEAERMALTVSTHEWTEKLSKRHSEADGQCVKWNTDQPEYFPVYNRYQSHIVFEFGASGIGKLIGQGKPEAIAVLWLQDLTDDIEGEVEIPVITGPNMQVLRQNVINDQTLKHHEFELVGSVTAKMTFSAGLDIQHEKLRLSQSRRHAFEAWMATEGESEISEMQKHFEDDGVIDKHEQKEIDKAHKRQLESRGRGMAQVGAYRSAKWIGRGIKDRLPGRKKTRERESIVQTEGEAAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHE8</accession>
    <name>K1VHE8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHE8"/>
    <dbReference type="FunCoup" id="K1VHE8">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHE8"/>
    <dbReference type="eggNOG" id="KOG3421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082438_3_1_1"/>
    <dbReference type="InParanoid" id="K1VHE8"/>
    <dbReference type="OMA" id="KLCFVVD"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="154" mass="17069" checksum="79580C3A447F0A8E" modified="2012-11-28" version="1">MQSQQQPSTFKRFVEVGRVVLVNDGPSAGKLAVIAEIIDHNRALIDGPATGVPRQQFPYRHLILTPYTLAKLPRAAGSGAVKKAFEKSGVEDKWASSAWAKKLAAREARKLSFRTMVADSQATTDFDRFQIMIAKKQRRGLARKAYAKERKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHZ8</accession>
    <name>K1VHZ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHZ8"/>
    <dbReference type="STRING" id="1220162.K1VHZ8"/>
    <dbReference type="eggNOG" id="ENOG502SY45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478181_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHZ8"/>
    <dbReference type="OMA" id="TYLWADS"/>
    <dbReference type="OrthoDB" id="2565097at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="478" mass="50884" checksum="939370127CCC4263" modified="2012-11-28" version="1">MSTTLLVHPTSLSLTTLPRVGPSTALQFPTRFPKGAEPRTAMSPAGHTYLWADSLPVVWEYDSKGRRVGEIKLTSSRERVKAVGCGEGVVIASTAGTGIWKRVEGKWTRTTELEQPLPFLALTKAGLLYPSPEGLTLHPLDSSTPTTFSLPSPATHISASKTGRVAICSGTDLHFLTLSTGDVSTVSLPEPVDSSTWIDGSNVAVRASGRLYLVTSEGDVSETSLDPVLNIHVLPPKRRPGSRASISTIGGGNVLGESSAPNRPDRRVSDIAHSAVSGEKGDKRRLVSAPALPAIERLRSENGTAKERTPKATPKNTRSSPQSVRTGGTVRIQPLDPQATRMGAVIEETVSIASSPAGSVASRRVSGDWATPTSHPAPGHSPHPSLSAPTQAAQLESPVSITDSPSNGYPEGSGGISVVAFEEMRREIANLQLDMLRMGRGLKNEIRAAVSPLVEEIRANREVIAKQREEIERLRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI59</accession>
    <name>K1VI59_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI59"/>
    <dbReference type="HOGENOM" id="CLU_321373_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI59"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="987" mass="105684" checksum="C21C7775B6B77A41" modified="2012-11-28" version="1">MLRYLYQRGAVSAKTSPTGLTPLGTPDGRMQLKTHAEAAYNNGAFMARTYKASSPRSTASTTSTTKLADRHYPPIQISTMSSSLPPLESGKVQLPDGLQLHVTSYTDMDMNDDDPQHIRDDHVDIIIGIVVAFVVVLIAIIAFFCSVRPFPDCTARVAIGVRTSHHFPKFVALPHHAVHAQSLLSQHLFARSLPFFRSLLSSLAFLPATCAHLSVRSKAAMGVRRIRRAQLGGAGETSSFADSRRSRTTTTHNSASGSLPAFASTSVSDPVSSGPTLHIRHHDDKDESRTTKIVAGTAAGAGMLLLGGLVLIWYMVWKQRRRRNRERARQQARCKADSSDPLTVEQPVIITPFPMSEPANSPPRSPPTSMRTHLSDPGPGAHHAKPFAYLQTDRTGKLGYPSSPAATRPQPKRASTELVTRDELKQAQRHSTIDSTPYNGRRRGHLPPPVIVFTETEEASEPRAKADSSDPLTVEQPVIITPFPMSEPANSPPRSPPTSMRTHLSDPGPGAHHAKPFAYLQTDRTGKLGYPSSPAATRPQPKRASTELVTRDELKQAQQRETASLATLRETVAGTGRACFAADGPGFDQQYAVADASLVHWPTASVLTGWYATGRHADSHAPFVNWPAAASTLAACSASAPPRRAQTAAHAAATASARISAPYPPPESRRLNAAILLPAQCSELHSSELARSQSTCAPRPQSSLPLSRHQSLLRSARRWPSPPRQLSLPAPLGVLPPSAYPNKRYSVDQLPARGTQSTTVQSLPFGARPARTPSPGRLSDRHKRGSEEILVRRASEQDLLAAARMGRSTPSPSGLRLVTARTPSPGGSSISSSSWPLPTPLNDPANTPPVRGRPLPGTPTSAPATPTGTPTATPGTPTLIPATTGQSTGSISRPLPVPPPLSSPTQPKSPLPQIPDPVVQEQRVVKDKSPVSPTSMPSDQPPPYSYSPGEALPEKTRGPNVLSRTASGSRQACVYKPSARPGQQYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIZ0</accession>
    <name>K1VIZ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosome complex exonuclease rrp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIZ0"/>
    <dbReference type="FunCoup" id="K1VIZ0">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIZ0"/>
    <dbReference type="eggNOG" id="KOG3013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034114_3_0_1"/>
    <dbReference type="InParanoid" id="K1VIZ0"/>
    <dbReference type="OMA" id="GVNGFIW"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="277" mass="30103" checksum="7C5A0B0A49810035" modified="2012-11-28" version="1">MPARLAVPLPTGKLTNRGHGTYVENDTITSSVAGTLERVNKLISVRPLSTRYVPEVGDLVIGRIVEVAGQRWKVEANARQDAVLMLSSVNLPGGVQRRKVESDSLKMREFLAEGDLLVAEVQAFFSDGAMSLHTRSLKYGKLRNGMLLSLSPRLIRRLKSHFVHLPAPCGPHGVDVILGLNGYVWVSLGSKQSREGAEGLESEGVYRNDNDEMDAEDRAAITDVANVISMLAAHDVPLSDTLIAEGYAWLREVGVTPGSPASKELGDRLVRELALTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJA3</accession>
    <name>K1VJA3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJA3"/>
    <dbReference type="STRING" id="1220162.K1VJA3"/>
    <dbReference type="eggNOG" id="ENOG502SYU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383648_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJA3"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="168"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="721" mass="77708" checksum="F97A5C4B50F04117" modified="2012-11-28" version="1">MQSELLAAAVRAAEVYPFKSTVTGGGGGRKQIDHNYKHPDARDMSGILSEDVLCFAEDQFSGDELELLTDLAESLGATVENTQTSNAILITQPYSSSYTVPDVPSASYHWLGACAAEKVRVNPNELDLPFFVSQPSEGNPDSRPLRFWVSINVKRDRAEPAEIAQACIQAKLRRHGGLIVSKRSQADVLVVNRETEFYRTVKKEIADKGRHWQTTAEKEWVDACIAGRELLSATDVDLGLKTQRSPSVESVTSEEDVRIGKGPGRPVGRPRNEYTPHDDDFLCRFLAAYYPHGSHGSRKTYQDLGAELFTTAAHHTAQSWHERFKKNKAIMSRRIARFQADGIGLDLKTDVERERDKETKRRLAQQKMQAQTQPSTSSQASPKNARRAFVELDDSDDADRPATKRQKASTQTATQLALGRGRAAVLGARPSLGQAGPSQQARRSTTPERPQPSTSPSRLQPTGETAAISQGSKQSTSASGREPPEPARGQPDTEESTQDSAFSRANVSADIALAPPEEEDGSDGDEQPAASAAVARVEVGEIEATTQQVPSAGQDPASSGDNAGQKAVQNVTASVSQPPSAQHTPRTAPASRPHSPAAIVPSPSSKQPGPSQPGPSSTPASPRSHDLLNAPRTSTPGSSRNGSRNASPASTPSQRVARGAALVTTARETFKRNIMAYSEKYGCTPTELYTIVNGLGRKGAGKGGQMYWDDVERGLRDKFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJL1</accession>
    <name>K1VJL1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJL1"/>
    <dbReference type="HOGENOM" id="CLU_2374269_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJL1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="95" mass="11372" checksum="CB9749E40704831A" modified="2012-11-28" version="1">MPNYNFNFRFFAHTTDVAEYIHKRREDEEEGETQLNQIKERKLRERAKLEEEFRTAKAERDKINPNLLEEQLEIAEYTADRTGVGYPVPQEGREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJS3</accession>
    <name>K1VJS3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJS3"/>
    <dbReference type="FunCoup" id="K1VJS3">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJS3"/>
    <dbReference type="eggNOG" id="KOG1723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089419_2_0_1"/>
    <dbReference type="InParanoid" id="K1VJS3"/>
    <dbReference type="OMA" id="STQWRIA"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="273" mass="31491" checksum="EA3F6690A3478275" modified="2012-11-28" version="1">MRIEKCYFCSVNVYPGHGTMFVRNDAKTFRFCSSKCHKNFKMKRNPRKVRWTKAFRRANGKEMVVVRIKFDGSRCWKRKSGEGSTQWRIASMATAASTVPAAMALRSHRSAMLWLPNEAFMAVAGYREPRCCNPVAFLSSKLTPQDSTYEFEKRRNVPVRYDRELVATTLEAMKRVQEIRTKRERAFWKNRMSGNKSKNLREAAADVEKHIELVEPRTKTVDVEDKSAEREKIKIRAAKRKIMAEQEIAGAKKKKRESRLVPAEGGGMGMNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJY6</accession>
    <name>K1VJY6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJY6"/>
    <dbReference type="STRING" id="1220162.K1VJY6"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_2_4_1"/>
    <dbReference type="InParanoid" id="K1VJY6"/>
    <dbReference type="OMA" id="FRTEEKW"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="7">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="27814" checksum="4B74F4FDC1960154" modified="2012-11-28" version="1">MSKADLSGNIVFGFIMGAVNVILVELITHDGSDTKAFHLVPLICVCVAWGEYTIRAHTLFQLGSDQRQSQADTTVVKFLLFLYCYAIRSSSSQVQVLWEDHRNDLFTNGFSILSNAGGAKLKWWIDPVGAMVLAIIVIGLWARTVYEQFTFLAGIAAPREFVSMVTYKAMTFSEEIKQVDTVRVYHSGPDYVVEVDIVLDPEMPLWKAHDISQDLQDQIEALPNVDRCFVHVDHEVDHKPEHRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKH3</accession>
    <name>K1VKH3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="8" type="ORF">A1Q2_06011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKH3"/>
    <dbReference type="FunCoup" id="K1VKH3">
        <property type="interactions" value="772"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKH3"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKH3"/>
    <dbReference type="OMA" id="NCPWILR"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="238"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="498" mass="55720" checksum="00F6C36E841FBFA3" modified="2012-11-28" version="1">MSADAATQADLAKYDLTQKLIPQLDRHLAIPLIDHLSETKVFPAAQVTKAQYDLVKGTNMVDYVEQLYEQAKAEGVAVEQTDFQKLRDEATARYKSLQDAAQPIMKVIEDPEAVAKLKGGMDKEKNVELLRTDYNISLEQINALYHFGQYQYSLGAYGDAANFLYHFLIFSPTQELNISAHWGKLASNILTGEWEAALVEVKDLRDLIDNPQTAAQAKPLNQLQARTWLLHWSLFVFFNLGDAQGCQGLLDMFLSPAYLNTIQTSCPHLLRYLVAAAIISRRAPKPAGSRSNRDHVKDLTRIVQMEEYQYSDPVTAFLKDLFCDFDFERAQQRLAVAEQVVQKDFFLSGFAADFVENARWLISEIFCRIHQRIDISDLSKTLNLSYEEGEKWIVNLIRDSRMGVDAKIDLKSNMLYISRPQSTPTTTLIEATRGLAFRSQAVQVAMQNTAEQRSGERGGRGQGGERRGRGGRTGGQTRPNAGQQGAAPATQTEGDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKQ1</accession>
    <name>K1VKQ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKQ1"/>
    <dbReference type="FunCoup" id="K1VKQ1">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKQ1"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKQ1"/>
    <dbReference type="OMA" id="SSYWTEH"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="393" mass="43745" checksum="54C445D47EE8C933" modified="2012-11-28" version="1">MGLLKQKHNRQQHDHAHHHDHPNAVARKPSVDANGSSGADVPPEQKAGWTSFIKQLAHMTGDLSSMTAPPFILSPTSLTEFPAYWCEHPELFAAISEGKDAEDRAERVLKWFIATLKGQYTMGSEKKPLNPVLGELFYGSWPDVNMRGETELVVEQVSHHPPITAYWIQNKEAGVTLQGHSGQKTSFSGTAIHVKPKNGDAEESYLITLPKLRIDGIIWGSPYIELTETSAIQGSTGYASHIEYKGKGYFSGKAHSFKAELSKNGKKIQTYEGQWTGVSNVGSAKGPVFYDASAPKQEVTVKPIDQQGEWESRRLWQQVANGIRTGDYETAGREKTRIENEQRQRRKDEQAAGTPWQLVRFEHVDSDPEFQKLAAMMSDKAVPATEDAYVFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKX1</accession>
    <name>K1VKX1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKX1"/>
    <dbReference type="eggNOG" id="ENOG502RXE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499845_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKX1"/>
    <dbReference type="OMA" id="CPTPFVQ"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="95"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="545" mass="59547" checksum="113F24CD7069109F" modified="2012-11-28" version="1">MSRQTAMPPPPLPVLSSSPNRSGMPSPGMLAPNKYSQRGSMPPPKLPPPSCRSSTSSRPSFALSDGSDNNSVYGNPNSSNERIKTPLQDSKQDNISTMDDVEAQFANLMDTLEVPSSVRLKFGTVGRDVKQSILMSSQTSNPAILGALGLPAPIQGKAAPQKPKMKKNSSAPFLRKSRSSASLDGEPTQVGGTYNYGGDQFTIVASPSARPAGHSRGQSVDVGRASTPLGRQRGSVPPSPRKVPPSPARSDRSFRGSTGPAELPESYVQWLKSSKATDLNMDVGKAKKLRMLLRHEATGWVASFIDAGGYDRLLDRIQDLLDVEWREEQHDDKMLYELLRCVKALSTSEVGKAALRARHPRPFPALSQLLFSEKKPGELACRQIIVEMWLFHFELFPPQSEVQRSGSIRFETANQVDVVDFVRSLLLPQKEDKAKDYHDFITQAHRPRIFKAWVQEMADLCRDYFWIMCHGSNTLWRLSEVDVNAVERPVAPGGATGGVEFEAMGYAVSVSQRTHLTTDHSLPPPEHAGASDGRAEHGQGSSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLI0</accession>
    <name>K1VLI0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLI0"/>
    <dbReference type="HOGENOM" id="CLU_2185775_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLI0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="109" mass="11835" checksum="24A101B8A112E9B3" modified="2012-11-28" version="1">MSGAMEEGSYTAQTTHSHSPGLVAKTRLATDAPYADLHARDEASGRGTRLLRNVRRVPEHPENPEDPEDPEDGDADHPGAMPTLDCDTASPLARWLVLRSPQRRSPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLX5</accession>
    <name>K1VLX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLX5"/>
    <dbReference type="HOGENOM" id="CLU_1066295_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLX5"/>
    <dbReference type="OrthoDB" id="10549540at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851953" evidence="2">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="220" mass="21985" checksum="BB8D8D2EFC810246" modified="2012-11-28" version="1">MRVTSVLLSLAALAPFAFAQDNAGGEAAPAPAAEGGDAGAQAGSGGEAAHKTGSAVGAHSSNTGHGGGTGNQDWVLSTFDVPNRNYYWVNEVNNTATWTPVNVTTNLAIYNSNSSVLDGNKEIAAGIPAGVGSWTGLVSGFAPGNNYIMILTLGDQPDRKIAQTEGFWIKSKGTIPEASVTGAGNSIAGTLAVGSATNRSLATAANDAAVILSLLNLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMI5</accession>
    <name>K1VMI5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMI5"/>
    <dbReference type="FunCoup" id="K1VMI5">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMI5"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMI5"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="43945" checksum="72CD8DCEDED8B2C7" modified="2012-11-28" version="1">MDPHRDENLPLVVDNGTGCGWAGSNFPEYVFPSVVGRPILRAEERLGSSKLSDLMVGDEAAENRSFLQMSHPMEHGIIKNWEDMENLWDYTFNNKLQVDTHGRKILLTEPPMNPKANREKMAEVMFEKYGFGGVYVAIQAVLTLYAQGLQTGVVVDSGDGVTHIVPVYDGFALPHLTRRLDVAGRDVTRYLIKLLLMRGYAFERTADFETVRDIKEKLSFVSYDLDLDKKLADETTVLVENYTVGSERYEAPECMFQPHLIDVEQPGVAELLFQTIQAAAVDTRAELYKHIVLSGGSSMYPGFPSRLEKEMKQLYLTRVLGGDAERLKNFKIRIEDPPRRKHMVFLGGAVLADIMKDKDAFWVTKEEWDEQGVRALDKLGRGDKVCYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMP7</accession>
    <name>K1VMP7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMP7"/>
    <dbReference type="HOGENOM" id="CLU_1807586_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMP7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854247" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="139" mass="16024" checksum="3CA84A45C42D664C" modified="2012-11-28" version="1">MVSFKSAALLFLAATPASAKLWGWPESWIMKAETTKSLWGEPVWQVCDGFSPCNDKCTGVEEFTSNGFRDMRNFSWAILKRKKSAWIDMWQVNSVTYHLYESGKGENGPQGQCEIADAVWWQRKCGSKKITIKMRCWQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMR3</accession>
    <name>K1VMR3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC98007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMR3"/>
    <dbReference type="FunCoup" id="K1VMR3">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMR3"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="InParanoid" id="K1VMR3"/>
    <dbReference type="OMA" id="MLCLNSQ"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="164" mass="17938" checksum="DD95E21527A8BDA9" modified="2012-11-28" version="1">MPPTRPSTATATPPYPSSRPGSSRPDSPAKSATANSSLILRKQLMADDRPTDTLWEGAILKARLIFPPLTPVYNTGARKGEVCVSILHAPGEDQWGYEDAGERWLPVHTVETVLISVISLLSADVPDLNSPANVDAAKEVREDYPAYKKRVKRLARRSAEEAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN25</accession>
    <name>K1VN25_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_00080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN25"/>
    <dbReference type="STRING" id="1220162.K1VN25"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN25"/>
    <dbReference type="OMA" id="KYLVNCM"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1092"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD05590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125316" checksum="7F3058DA2510EEFD" modified="2012-11-28" version="1">MARYDDAPLPYSSSGPMPTRNPTLRRGNTRGGTVKRSKTLTRPERHVAPEPLINPGTSAQTTPAEGGNWNWWVLTSWIATFYAPPALLRACGIKDKQTQQAWREKVTLCTIAVIMGAIVGFATMGLQSALCPGGETNKAYQLLGSQNRYAFDISESATPEHVNFYQLANNMSGQDITMLFQRNNDDYPECQGKNAKYATSPLCPTKDPSGTSTDPICSLPQLNKQTVETLKLKNLTLWEGYSWEQVAKLDDYLVLDGYVLNMGPYLAANPNSIENDPVDQVIRRALDKQRSSGKDVTNQFYHTQELRDAIPCMKSRYLAGHIDKMTPGCFVAALFLYCSLGVILGVVLIRFFMALIFNWFIAHRLVEKQDVHGRAIAPTVMPEGANVSVNNQNGTAPWASGQNGQKSAPAPIMDMAQIGQDLFTVCLITCYSEGEEGIRGTLDSIASTTFPDQRKLLWIVCDGMITGAGEKMSTPDICVSMLDADPRFGNPQPMGYIAVGSGAKKENRAMVYAGHYLTKNGHRTPAVIVVKCGMPSEANDAKPGNRGKRDSQLILMNFFSRCTYNDRMTPLDYDLFRKVQTLMGVTPDFFELCLMVDADTKVYPDSLTHLVHCMANDSRVMGVCGETRIANKRQSWVTAIQVFEYYISHHHIKAFESVFGGVTCLPGCFSMYRIKARKDDDDDWVPILVKPEIVREYSQSDVVTLHQKNLLLLGEDRFLSTIMLRTFPHRRNVFLPQARCRTIAPDEFKVLLSQRRRWINSTIHNLMELVLVRDLCGTFCFSMQFVVFMDLVGTIVLPIAICLTGALIINSIIKPPTDFVEAIPLMLLACILGLPAVLITLTTRKMIYVAWMLVYLCALPVWNFVLPVYSFWHFDDFSWGETRKVEGEVVDKAGHGGDKAIFDGTTIPLRRWEDWERSRLRKLRREEKRRKQMERAHGQGFYNDDPDALTIPRNVSRAALSDDSGSIMSSEEDVWGAEIGGYNENHPAYPPPPMALAPNAVAARPGTQVLGMDEMAALLDQGFDEPPAAAWRPERNESSPLHRHPAQPADYTRTPKASPPNEYSPLSPRSSGGGSPMPSASASMGVQLQDHGATSTSVESGQHQGQHARQRSKTYGPLGPLDDYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN91</accession>
    <name>K1VN91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_04805</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN91"/>
    <dbReference type="FunCoup" id="K1VN91">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN91"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="InParanoid" id="K1VN91"/>
    <dbReference type="OMA" id="IHGPEQR"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="240"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="452"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD00932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="618" mass="68112" checksum="DDAD78FC7ECEA502" modified="2012-11-28" version="1">MGRDIELAEYIVERLKQAGVKQVFGVPGDYNLEFLDYFERDPVLEWVGNANELNAAYAADGYARIKNNLAVLVTTFGVGELSALCGVAGSLAERVPVLHIVGAPNTKMQSEHALLHHTLNTPGTFTTFSDMSKPLSCATATLNDVQPETRRTYADVFDDAVRACLTQCRPAYVELPMDVLHVKVSDEGLKHPLPRPSDPPPYGALRRTTLAGAQEPTNVLFQAERAPAYATSEEVTKTVVKEITKRFAAAKKPIVLVDACAARFGVGPHLKKLVDECGLRFFTTPMGKCVLDESSELYGGCYAGQNLLPEVIKDVESADFVLYVGALKSDFNSGSFSVKIPEDYAIRLHSYTTEIGYASYPTTDIRHVVPALIPAFKEVVDKQGKPKSKRDTVAEKIDAGLCEKLYDAPLDPKGKITQAWLWGRMGSWIRENDIVICETGTSSFGLLSVPLPKGVTYVAQVLWGAIGWSVGAALGCVLASDEQKQDRRTVLFVGDGSLQLTVQEIGTMVRRGQKPYLFVLNNDGYEIERQIHGKHAKYNDIQPYDHQLLLPFLSGPKREQTESFKVKSQEELDRLLKDKDFSEPTKIRLIELDMPRDDAPEALIKQAQLTAKANAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNI7</accession>
    <name>K1VNI7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNI7"/>
    <dbReference type="STRING" id="1220162.K1VNI7"/>
    <dbReference type="eggNOG" id="KOG4462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547473_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNI7"/>
    <dbReference type="OMA" id="NAFGHSQ"/>
    <dbReference type="OrthoDB" id="2596981at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005404">
        <property type="entry name" value="K_chnl_volt-dep_Kv3.3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01582">
        <property type="entry name" value="KV33CHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="554" mass="54055" checksum="0C17FD070BADA876" modified="2012-11-28" version="1">MNAALLQQIQAGKGLKKTQTNDRSAPAVAGSVGGGGGGGGGGGGGGGGGAGGAAARPPPAPNPMTADNPAQQLAGLFAGGMPKLKKTGGPAGHSAPTGLAKPPSIPGRAPPKPPSAAPPPPPTPSAPGRAPPAPPAPPAPPAPSAPSRHVPAPPKPPPAPPVPGGAPKRAPPAPPPIPSHGRAAPPAPPAPSRHVPTPPAPPAPPAPPAPPPQPPRAPPAPPRPVSSAPAIPKREPPSLPGRAPPAPPRPSAGGRSVPPPPPRPSGSPARVPPPPPRPNQSTPSPPPLPNRAPPLPNRPGGGGRSRAPPPPPRPTGPPTLPARTPPTLPGRSVPPPPRRSDSPEPPAPPLPRRPSGGASRTVSASSTPPPPPPPPPGPAGRSASQRFAPPPTRTAPPPSRAAPPSPPAVDDDEDDAPPPPVGRSPAARALAAAGRLRSSSNASTPEISAPPSRATPPPPSHPSPARASPSTRPMSMMPPSHPGMGAGKARPASVALTGANGRDGDSDDEPEPPAVVGSWTFAMKGMFPPPRPWHGGHKTYASGATTGGGIGYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNM3</accession>
    <name>K1VNM3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNM3"/>
    <dbReference type="FunCoup" id="K1VNM3">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNM3"/>
    <dbReference type="eggNOG" id="KOG0171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1284087_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNM3"/>
    <dbReference type="OMA" id="IWEYVIS"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="75"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="215" mass="22810" checksum="A5DFC745050BA6D7" modified="2012-11-28" version="1">MLSRVRPLVRQAPTQFRHASTRTTGRVTATSPSSSSPSASSSSSSSSSSSSSSPPPGGKRRWPGLRYSAKVTLYAAQVACFAHLVLAYVGEVSGTSGTSMLPTLPADGSILVVSALAYWRPKWMGGNRRPERGDLVTFPSPSNPEYAVCKRVVGLPGDIVEVEPRRSDDDPGWLAGHVVERRGQGVFIKVSIHTPATSFLQASRAIGSLAASQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNP5</accession>
    <name>K1VNP5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNP5"/>
    <dbReference type="HOGENOM" id="CLU_1116423_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNP5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="27104" checksum="4CEB0397DE9038A9" modified="2012-11-28" version="1">MGSDLSQNRVKPKPANRSSKRRAAPNMPAAKTTSAGSRPITAPVVKRPRQRRERDDRSITRMSSGTPDTPISLPRPYRSPSPDHHSGNSASAESNTKATNLGAEIEILRTQLRAAKAEAKTYQDENADLNYRIMEAERRAEKAETDAAAAKKRAKDAGRTLGQISKLKEAAKRRWQELEVELKLAEDEAELATKGKEEAEKLVEAYKLVLKNHGLLAGGMVGAASAGRDGASTEVTEPSYGDVEPIIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNZ3</accession>
    <name>K1VNZ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ER to transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNZ3"/>
    <dbReference type="FunCoup" id="K1VNZ3">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNZ3"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="InParanoid" id="K1VNZ3"/>
    <dbReference type="OMA" id="YYICISC"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854269" evidence="10">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="211" mass="23757" checksum="AA8162165CC22E53" modified="2012-11-28" version="1">MKLTTLLLAAQVIGLAQALHFYFDSSEKRCFVEELPSDTVVEGKYGALVWDDGKQSWEADPGLQVRVNVEDLSSAQVVVNTKGPHTGTFTFSSHEAADHQICLSTEGVGSGHKHVKMYLDVNVGPSKHDKESDQRHIGTLAGKLNELNKKVADIQREQRYMREVEEQFRDLSEATNARAVWYCIAQIVVLVAAGVWQMRHLKVYFEDKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP82</accession>
    <name>K1VP82_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000283">
        <property type="protein sequence ID" value="EKD02436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP82"/>
    <dbReference type="FunCoup" id="K1VP82">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP82"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="InParanoid" id="K1VP82"/>
    <dbReference type="OMA" id="SFWPRTW"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012700529" description="Glutathione hydrolase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="469"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="647" mass="69106" checksum="29207B8F2AAC4B00" modified="2012-11-28" version="1">MTRLWALFLAATALATPFDPRNNWGNDNDNDKPGKGDGHGYGHDKDHHNDHDHGHGHGHGHGDGDGEPQGNGTSPYQVMAEPMIGIPALGLPAPSNKTRIPGYLLGPGKSGVASEEKTCSELGVSIMKDKGGNAIDAAISTTLCIGMLNAFSSGIGGGGFMVVRVPGQKAKHKAQVTSIDFRETAPAAANETMYKDTGRNGSQIGGLAVGVPGELRGLEAAHKLGGSLPWNELVEPVAQIGLNGWQVSAELAGRLNKSAWITDSPRFRDIYFVNGKMAVEGDTIKREKYGNALMKIAKEGPGAFYEGSIADDIINAVHEAGGILTHEDLKNYTVRQKKAISSTFRGKTVHTMDAPSSGLVMLGMLNIYEPLFPGREKCWKEEDIHNRLEAMKFAFGARSGVSDPAFNANASEFPKFYSKEWAKEQRDKITYQVHDASYYGLNKYDAPDHGTTHIATLDEDGYSASITTTVNLLFGAHLATPEWGIFLNDEMDDFAVPGESDAFGLPPMAVNFPQPGKRPLSSTAPSIVEAPGGKSVYAVVGGSGGSRIFPSVAQVILNAECGDDISAAIERVRWHNQLSPNITSVEVGTGKDAADPEVIYGLLRRGEIIGEYDINAPQGQVQGILVNKKGELYAASDSRKHGVAAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPD4</accession>
    <name>K1VPD4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPD4"/>
    <dbReference type="STRING" id="1220162.K1VPD4"/>
    <dbReference type="HOGENOM" id="CLU_333228_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPD4"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="714"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="858" mass="94091" checksum="EE741E5ABF30221D" modified="2012-11-28" version="1">MPLSPYGPLPPPVARYRPFPSDSYEVVSSAPTPRRRSPSHDLMSPITTPGSIGLRRRGRQATACTECNRRKQRCDGVQPCHHCAKRNVPEACRFPESSAPRPATAISLPPHAAHHHPYFSPPSDTEKKRRLSDDPHLTPKPVLLPPITPIAMGRTASMHSVHSVHSAHSLQSLSQMSSGRSVPTLSPMPAASPDRGGDDDMRPSPGYRAYRPWSRPHLPTPGGSFDGHGPPAPYRRDQYFAVQQPLSSERHEIRTPPPAPDTRRASDGSDSSGNWRPPPPQGPQADGDVLMQEGGAQGFGSLAHEGAGEEHSPTADDQGDGTTLLNGASAEELVSPLEEGAPEALLEQIRHVDSQLPRRSLCERFVKAFFDLNNSWMDILYEPDFSGKYADLWRIRGEFEDLGRIDLRWLALFQVVLAFGALLSASTPEEEKEFAAMSSRFFDCARRALSEAPTYRGESMDTVRAYALIPCRRASVEPAAEGGRTPASSLGSPPACDPRREFHNAHAGQPLRRGTDAARLAPHHGDDQVHLPDSALPPRADHRHHPHAVLRPDSTPPRRGDALRVPPARVGGCAPARLPVPEPRHVSRRHAPVAPATAPDPREQVPPGAYLPAPAVSATRRLSAEPHGDDKDPFDRFKWMVVASGFAPACVLGLLLARKQRDCEYNYREIRKLFVAYLDAEKATQRRLDRHLRSELMVLDQMLRQANEIDRFLQRTSPVKSEPSRQLPDPAQLDSESSDEDAGPASVGATGDRPDPLVSRAVSRAHSPFLTLGQEFSLPPPALPLQYPALQGENSDTPTLAPMFDEWPAPWALRPPSDPTATFPAANDKASWDRLLEIIGPPPEPEPWYDEQVVVADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPQ5</accession>
    <name>K1VPQ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPQ5"/>
    <dbReference type="FunCoup" id="K1VPQ5">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPQ5"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119276_0_3_1"/>
    <dbReference type="InParanoid" id="K1VPQ5"/>
    <dbReference type="OMA" id="YISQRET"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="95" mass="10934" checksum="8A99FCC1B312C8FB" modified="2012-11-28" version="1">MVRSKFKDEHPFDKRKAEAERIRQKYSDRIPVEKSDIPTIDKKKYLVPARIKLSPEKAIFIFVDDILPPTAALMSAIYEEHKDEDGKLAPAHVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQK6</accession>
    <name>K1VQK6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQK6"/>
    <dbReference type="STRING" id="1220162.K1VQK6"/>
    <dbReference type="eggNOG" id="ENOG502SAS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331204_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQK6"/>
    <dbReference type="OMA" id="WERQTRN"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="881" mass="94611" checksum="5928840C0B0094A4" modified="2012-11-28" version="1">MSHATTADETPASQPSTGEPTDPDPSTSSRSPSRASSRTQSKNTPLLTLAPTGRQTPQDEDIPAIWNVISRAQDVVKDAERLENLTWRHWGRPQRRRRSSSIDTASSASVHTPQEPGPIRDKSAERRSFAGTLKLLVEDDSSFKDWVGSAKSQQQQSSNSLSPSRSIAESHGTSDSQRTPHPHQFGLALPPETPTAGSLQSQHSPHAAGALTPVPDLEIRLVEPTPVPSRVGSLGGVASDRITATRPATQPQVAEVEEEDAARAADGQKQPRTRKGKGGGFFIQSSPGKASESESPKSQPSPVVAPVTSTKAPPGGTAGPSRPTPPSGESESSNAIVMNKKKDPRRAISMATMHGRFQGEKRRAAQAIAARNAEDDSTTAAEDDNDDEWEDDDDEDDDDGWEDETPSDPKPVQAQPMVRQTSRGLQLPPIQLPVSAATKKQRQAEKARLEAEREAQRQREMFAKQQIFGHPQGGEGLLTRQFKTGKSMVDLTKAGEESSAPPGLRRAPTHANFSTMGQSPTAGPPNLMRSKSTAAMPVQTGVSVTSRRSHNSGHSDEKRGPEGVEMESSDESDEDDYLASTAVERKLNQLAAKRAAKDSGANSVPIVPNGNASGQALDENGVVRPLSPTTRRRTIIMREMSESLRRNIILEREKSSGGVGPHTRPPPSTHMSRLPTSNSAVNLAQYRDGRHGPPLSRHNSNFQLSTGGEELRGPELERHNSHPDLIQTRGHYEYPRNPASSSGGSRSTSPLQPTASISPETSRKRANVLGGGFLRPLTRATDEATSHALGRTQSSLSINGSHGGHGSGSGSERAGPGVHGTQQRSVTLNGPPGRRGSDRSIASATAMVRSSTEGDQKEMERARVRRELARRDDTSYRSHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQL5</accession>
    <name>K1VQL5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQL5"/>
    <dbReference type="STRING" id="1220162.K1VQL5"/>
    <dbReference type="eggNOG" id="KOG2288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467838_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQL5"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="583" mass="62568" checksum="A039095C55CC122B" modified="2012-11-28" version="1">MSFEARPRSFSGGAAILPDLPYATEPTTITPTPQQQQQQQAQQVQQVHQALLLQQAQQLQQQQQQQQQQHMTHQRKLSAPSPRQSPRLRQHALPAFTSISGAQDGPHPPVLSSIKLAQLGDGRNSKSAPSSPMGKPQTAGLSPLTTIQPLDIGLQAHTGLPASPSQQLPPQSQSHLPNGHGPLHSNTFPPPLQQQQRFVDPRLLHAPNQVAGNVNVSPEIALRGLAAGQPVVPPNAQPGGVMRFPMGAHGGAGANGAGGGRGMSHPQPSVPSVQARRPVAPMAPRISSQASNASSDDTEVDSDSTFVPGRIRAQQNRSRSQPDLQALRSKAVERWATQQDQERRREAARTEGNVVRRRSQGRKTPPIRAQTLTTPLNAYSSARYSPRQPAPHLSPLTTWTPGSGTGGSSSQESSDAESPVLHSPPGGMTGSEDADDDLDGDSPSSGSISFSPRARRRQRSLPIGPPRSAAALGLVFDSTHSEEDSPRIVDIRAASIEARFQRSSLIGLRLLAVVPALWGCAVLAHALCTGYLWEDPWPWGVDFSREQLDRLVQGNITEGVKRPVHRGDMLLAMIWVSSLFCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQM5</accession>
    <name>K1VQM5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein scd2/ral3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQM5"/>
    <dbReference type="FunCoup" id="K1VQM5">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQM5"/>
    <dbReference type="eggNOG" id="KOG4773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014957_1_0_1"/>
    <dbReference type="InParanoid" id="K1VQM5"/>
    <dbReference type="OMA" id="EYWFRID"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="346"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="693" mass="74775" checksum="5130558A0E4E8FAC" modified="2012-11-28" version="1">MKSLRRSLNNNGHSHPHGGQGAPNVPPPPHIAHGAMSPPGSAGGGAPVASFANPLSRPTEKVAPPQKVIKALKSHRSTNPQELSYNKGHFWYVTGEHPLTGSRGLVPKEDFEEFSKGGRPQGGGHQATPSGDHSRSMSQGGQARHGDRSSPTTPIGAPNSAPTTPGKKPTQPLYAIVQYDFHAERPDELEAKAGEPIVVIAQSNHEWFVAKPIGRLGGPGLIPVTFVEIRDPLTGRALDQFPSTIPQVEEWKKATAEYKAAAIPLGRLDLPANHHVPNSPYAPPPNSAGSQKSNARTSSPTPAAAAVASAPRSSGSREHQRNASQANSVGQGSAQRGYKPEQDQMLPPGELVQLGVPSFHNESGNYWFRLHASFVPDERTHPAYTLSLYRTYEDFYDFQITLLDTFPSEAGRPQPGDDQDNPPPRILPFMPGPVDEQIDDELTEYRRDELDAYVRALLDLRNKGAGYILRHELIRTFFAVKYGDYCEETPRQAAIDELEERLGDMGFESSASNNYARARTGSQQSSGLGHVRAPSNDAPVVHLGHTRNQSSGVHGGPITQSPSAMASPFPGAMHQSNHSQGGSGTGGRQHPAAQNSTGSTSSGPVPFVKIKIYDGTTDDLIALRVQRNVTYLELMDKVHQRLGPDISTLQYKVGGGPVGPNGAGGQNRRINNDRDLADWMNTEDQRLILYAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQV3</accession>
    <name>K1VQV3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQV3"/>
    <dbReference type="FunCoup" id="K1VQV3">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQV3"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_0_1"/>
    <dbReference type="InParanoid" id="K1VQV3"/>
    <dbReference type="OMA" id="MSMLQFF"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="116"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="567" mass="59185" checksum="F228804B5A0A04E2" modified="2012-11-28" version="1">MRSPFSRPRPASPRPTQDVTIPPPETGIETLGVVTIDSDDVDSHCTAYTHSTHDSKAASAASTPDSEKTLGTEKTIAATTTSDTEAEYGVPTLSTGDAESALLAEPHLSTVRQVILAGVMMLSVFLSTLSSQSVIVTVPRLASALHVSAVQAQWVASSYTLAYGCALLPAGRLSDVFGRRLPFLLGLGFSTLFNAVSGPVRSLIPLCILRALAGLGLAIATPAAFGIIGVNFRGRARTTAYACMSLGNPVGAALAMLLGGIMAQRDAFYLFYVLAGISALPLALGFVIPRDRATDADRRIDIPGSVMITAAMALLTFSLAQSAIAGWKSYVPGTLVLSVVLLVAFGFWEHRLEKRGGRPIVKLSMLAAQHGKMALVALCGFLTFVAVSGWVLLVSLYYQDLKGLSPFDSAVHTLPASVVGVFAAGAVLYLVPRFPASWIITIGGLSSGLSCFLYVVKPANLTYWAIEFVSAVLLPFGADFTVGTGSILMSNLARDEDQSTAGGVFQTAVQLGNAIGVCCASLLAEGKPGMAGLKDAFGFCAAFPWAVAIIAAVGFRGMGRAGDVRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQZ8</accession>
    <name>K1VQZ8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQZ8"/>
    <dbReference type="STRING" id="1220162.K1VQZ8"/>
    <dbReference type="eggNOG" id="ENOG502SSVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906695_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQZ8"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="307" mass="33189" checksum="3372374BE3E563CF" modified="2012-11-28" version="1">MSASLRADDSGTEHRPPAPARLYDPRPEGVWTPIKKIKSGIFAGRFMSDIEVGNLVCAAELCDPRGDPPRVAPRTIAKAARDPSSSPTTRAAEPTVMSPTSSSNIEGDEERIGARAGSQRAASPANLPRASTSRHPETPGQGTSARNRDNAPKTPPQAQTSRSSSKGSDRSRSARGGSRGRSRGDDKRVIVGRNLYGSLHVAGIRVAAMDGEAGLWFLFTFRCYDMSAIDPELGPIPHLVDTQSDDFRVYSPRNFPGLPKPTELAEHFALQGYKLNTRKVRRCDIQNAMADIQNERQQASPNPSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRA2</accession>
    <name>K1VRA2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRA2"/>
    <dbReference type="STRING" id="1220162.K1VRA2"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_0_2_1"/>
    <dbReference type="InParanoid" id="K1VRA2"/>
    <dbReference type="OMA" id="HNAQRIL"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="285" mass="30757" checksum="916068CFF9156426" modified="2012-11-28" version="1">MPASVGLCAVRRVGLGVGRLAPLARPGLAAFNCRAPSLPPRCLNLNRAFSVSSFLRSAPSPAPPTPSTPPPPPEKEKKEETELHESPYTLPNALTVARIIACPFLGWAIVKGDFAAATGILAASGFTDWLDGYLARKWNQKSVLGSIIDPMADKMLMTTLVVALTYDGLLPLPLAGLIFGRDLALSLWAFYLRYKSLPPPKTWARYWDPSMPSAEVRPTQISKVNTALQLLLMGVTTVSPLLHTDISTGLQALQLIVATTTIWSGLSYVGNSGFKILKQPLKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRL3</accession>
    <name>K1VRL3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRL3"/>
    <dbReference type="STRING" id="1220162.K1VRL3"/>
    <dbReference type="eggNOG" id="KOG2522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012487_1_1_1"/>
    <dbReference type="InParanoid" id="K1VRL3"/>
    <dbReference type="OMA" id="LCIIDDH"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="365"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="454" mass="48875" checksum="27ABBAC18F2AF236" modified="2012-11-28" version="1">MATPWKLPDVGEGDVVGLVSDTEGDGRVSFVGVARVVARGGLRDQLERLLRHRAEGVDRDEGKFADILCIIDDHGSKPALPSFPLPAPAKPLMPPPESEAPAKEDAADEAAEAVAELTVEDKGEPLTASEVSTLLSAALMQTLALLSPSQLPLPSSQLYSAHILPNRPAYIPPERRDDVVIARSEWKKLAKWMKELNKDGIIKTKETKGEVVVTSFDPAHPAIQAHRPFKTIAEDDTKAAKKAAREAATAEVAGTTVNKRGARELAVEEMWKPTGSGVAFWEACGFDHPANALKPAFDAYVTKHGLVGRDFRTITIDEPLAAALGKSMSPGDKVNRDEILRRLRNGVGWSVSVGGVVKKGNLQPVTMCVKTRQGRKQVTLVSGLEGFGVDIDEFADELRRLCAGSASVQPLSGASPKLNLKEVLVQGNQTKLVSEALVARGIPKRWIKDEGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRW1</accession>
    <name>K1VRW1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRW1"/>
    <dbReference type="HOGENOM" id="CLU_1397225_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRW1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20693" checksum="8D59B7E7FC649F6D" modified="2012-11-28" version="1">MSPIDLAALNPAPTATAYVLVPGQGIPGLTPPPDPALVAALNATLPALLDEAAQRNSAWSDWGIFFTILGVLAFFALICSGLALVYTTYVAEIQALQYHFDRLHRRLDADIERCAGQTAAVPERENAGSTPTSEAQYEPVKVPENPPVDAARESPKEAKKEVRFKEESDSSDGSDGSGGSESSEDENDPLLGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRY6</accession>
    <name>K1VRY6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">A1Q2_03409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRY6"/>
    <dbReference type="FunCoup" id="K1VRY6">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRY6"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_1_0_1"/>
    <dbReference type="InParanoid" id="K1VRY6"/>
    <dbReference type="OMA" id="NEVRHFN"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="349" mass="38592" checksum="16C59DFC49C88D88" modified="2012-11-28" version="1">MSVRTLRTLRSLRSASRLSSVRNAVARPTVSAPVLAPLARRHLNTINADEVAHFSKLSEHWWDEQGEFGLLHRMNPERVEFIRQKVALDPDNEPEWTFEGRHQDAEREAAKGTGQWLKGKRCLDVGCGGGLLAETLARLGGDVLAIDATAPNIAIARTHASADPLLPYVDEEGKQANTSAPGRLEYRHTSAEALLAAGEQFDIVCSMEVLEHVDSPGEFLKCLGAMVKPGGHLLLSTISRTPLAQLLTLTMAEDVLRLVTPGTHHYHKFVRPEELRRYVGTEMGGLDVWEANRDASDLREGEVGSTQGIIYDPLAGRWKLASAAEGTWFKPLGELVNYMYHAKKRPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS51</accession>
    <name>K1VS51_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000289">
        <property type="protein sequence ID" value="EKD02367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS51"/>
    <dbReference type="HOGENOM" id="CLU_412881_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS51"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="665" mass="70702" checksum="185956BA030B0A0A" modified="2012-11-28" version="1">MALALDLTPQPLSTGASSSRSRTADASVQAHLLPALPSAPHVPLPSLSSPLPTPSSLASPSTPFPSGSAPSAVSAPLAAASRLCPSQPTTSRSEPSLPTPPASATNSWPSTPPPSSAHLTPGLLLCPPVDLTRCSSFSSFATDDSDAMDMSDFDIRELCGGDWQRYPPLKATEPPAQAPSPVPSSFDTHESYSSRASLDEDSLPEHPYVDGFSTYIHPSLRKQSKHTKSSSGGAYPERTSSRRPSHIRRSRSASNFASMFQSDEAPPPVPPLPIHSPTITTQRSPIVPALMMRGPYPVTNPDKALPTDACAVSPPPLPPKTPDLPKSSSAELVSINEAAAMAVRRRTRSGPQPMPLFTSYHGNLSRSVDTPPRLHTTNKLYASPRQPHRRAHSVQHSIRDSKLIPDFTLPSRSSSRQSLKESISGPAPVLPDKLMPSSYNTPYPTRSAPSPPQQPVRRPIGSHRPAPPPPDLSAVFSSQRPLPPLPDVPASPVAAVSPVSPLPRSITLPVILTPPTVKPVPVKRRISILKNPLKVDASEPTSPGSLAKQQAQAWRKAVHDEAIAALREAETWDWPVPPMVPALERSLSISSASVSSPTKSLAELAADWDAAMTESPKRNVSSTFSSDTPLTPDLELEKNPFDTAAAKIVVTESSPRSVGSYGVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS68</accession>
    <name>K1VS68_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_03289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS68"/>
    <dbReference type="FunCoup" id="K1VS68">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS68"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="InParanoid" id="K1VS68"/>
    <dbReference type="OMA" id="EQNCIDR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="207"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="293"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="439" mass="47738" checksum="D588D0326FDBC423" modified="2012-11-28" version="1">MASKAKAKAKPNAPKTKIAIPPPRLDYARLLSDPEATARNVRERAMPLPSDVVAELGRLREQALSLETQLNRTRHEQGLASASLRDTKDKDGKAAAVARARELKEAVQALEREHREVEDTLLRVAGSLPNFSNPAAPIGAEENATTLETFGPERLPASPLRDHVDVADRFGWLDNAASAIATGTSWPFLLGALAQLEHALVGYAVDMAAREGFTPVSPPDVVAVDIAARCGFQPRDGPGEDAPRQTYTIESEGERQLCLTGTAEVPLAALWANRTLGADQMPARVVGVGKAFRAEAGARGADTRGLYRVHQFTKVELFAVTTAEQNRVLDMPTQELGASAARKYDMEAWMPGRGKWGEITSTSNCTDYQARRLHIRYKDAEGTHFAHTLNGTAAAVPRLIVALLENGAKIEDGEVTGVQLPRVLERYWVGNLPEHVEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSK7</accession>
    <name>K1VSK7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSK7"/>
    <dbReference type="STRING" id="1220162.K1VSK7"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="K1VSK7"/>
    <dbReference type="OMA" id="DIEARCK"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF25">
        <property type="entry name" value="NMRA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="30"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="399" mass="44141" checksum="983753FDE1E56786" modified="2012-11-28" version="1">MSSTGNDKSSTGNQQSSSGNQQQQTSSGNDKPIMVTGATGKQGGAVVDALLALNDPTITILAVTRNPESEASQKLMAKSKQIRLIRGDLNNTSLTYENAKFESPNGKIWGVFSVQTMSMGVKVEDTETAEETKQGMGLIDGALANDVKMFVYTSVDRGGAEKSWDNPTSVPHFRTKYLIERYLRSEATGRMNWTILRPVIFMDNIENNLPSKIVMTAIKSSIGNKSMPWIATKDIGFFAAQAFADTDKYNGVAISLAGDELTFDQLNEKFKNFTGHDVPTTFSFVGSALNWLSNEMGQMCNWFRDEGYFTPNLPELRSIDPHLLDFDTWLRQDSDWSPQVMAAKDGTTTTTDVVVEERTTTDAPPKSMDYVSPNYQYTDEQKQIYEQGQQAAVDQHQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSR8</accession>
    <name>K1VSR8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSR8"/>
    <dbReference type="HOGENOM" id="CLU_1305662_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSR8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="211" mass="23408" checksum="A87CD18CDADF9224" modified="2012-11-28" version="1">MTTHRNPAQSLNWHPDWSSGGDLTLLSSDEVAFSVPSRPILAVSPALRPGAGGLLPLPLSSRLVLYFLDLALYGQLDFLGPSDNYLTDVLSLAGWLDSLGATSLINLLLVSGRAQRWPLAVEFLLGARLRRTDLCREALNRFNDDGRWRDTQWQPPGTVSDFATLCPRALPLDLWSSVDRRFMWAWSVADVPDTPPSFGLGDKFLEIYQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSS6</accession>
    <name>K1VSS6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSS6"/>
    <dbReference type="HOGENOM" id="CLU_159502_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSS6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="95" mass="10544" checksum="CC1D49A1C88482D8" modified="2012-11-28" version="1">MAPILDEKDVVNLAIRWEDAKNKLTPNHTQVYVGGGLCLHMLTFRVTLSVAAVYALVILIPLGRAEEGWLEKWRSIAEKEGIARNRSDGIANTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VST0</accession>
    <name>K1VST0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VST0"/>
    <dbReference type="eggNOG" id="ENOG502QWKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248524_0_0_1"/>
    <dbReference type="InParanoid" id="K1VST0"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="378"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="801"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1504" mass="168354" checksum="95119B0228BCAB7D" modified="2012-11-28" version="1">MASVLAMSEAHRFRHPGNGTHGALRKGPDLGLGAGIGTSNARMPRPTVDHSSVNAHNHKPHPSPQPAKHTTHTSHTTYSKANPKDRPGFPGTLSNRPFTAGTTSAQSSLASSSNTSPSRLPTLAAKRDRRDLYPSANGDSASSSQATLRPPNSASTSAQKQLNGDYRLLSDVSLNGYRSNASSTYSSPASRNNSPDPTTLSRSQLASPFQPSAGPSKLTAGSWRTGLDRLQDLDLDFSHQQQRPSYGLAGLSEDDDRQDDTGYREREQHKRDSDRFTAVPRPSRSRSKPRNRDRRSKIDVRALASPPPLERRQTAPTEDSHDSSAASAGTSGTNGTHMTTMDLSALSHSTGSTAPTTVTNGTSSRPHTYLDNDEMHLALLAGQAAVDCDKLPISTWDEVELWKKELSHLSSRLDTLQARHQREVKILTAARTLQKLNTANKRISRHTMESLEQSERRVAAAEKEVLVLRDREAALRRRLMEHWAGVMAWEVRRLERAAAGRQEKQDLFLLESRRREEALHDHIASLEAERSMSRGMDDSLDSSDQVSEMLSRLELSQQNQQELEHQREQLQVERDILHREKEALRQERDALHGEKENLSRELVTLQSSQESQRADADTQKKTVERYQKRIADLEEMVVELSRRERALEEQIAEAPKADELAALSAEREQWEAERARFDSEREQHAAAREQFEAERSTWAAERGEWNDERAALDLKLSKHAHLISEFADARKSWDVERERHQAERTAWESERSQWDNERNQWHADRGVAADNQSLFDTERARWAAEREALAAERENDRAAWLADQRAERAAWEQQRDAWERERAQLEQQLNKLELERDMANSDRELSVSRHDALAARHDELRSRHEALQDEHTALRSTHDQVLGDHTALRSTHTKLQSDHARALDDAAAASNVSKTMAKKTTMALAAILGKLVPEDELGDAAVEVRQLFERQSKDLADLRDAMDEVNKGLEEEVRRVTADRDRWRDKADELVKAHDTNVSSSREAQGEMTELVRKIRAQNEKIAELQSQLESQPRALSPSLLSPDQASLSQAWALLPSPKARAEAGLTEANVVSPSSHVNFGALQHAYSVQSNDGYPGTKGLVERIRGVVDDGRVMAERMARMEQDKERHKANAARAAKLVEESQRSLATYQKQVKDLQDRLQQATGSPVSSPIVSPVRVPDLETRYALDDARAEIATMRSEAAKRAEELAKLQESNQALSTRTLTLAEEAEAAKMAAVGKLQREQTLLQAELDTLRSKIKKQEADTDNERARQTAQNMTLLEESGSGTPNSSSALGDRGERERSERERQLEREQGKRAGLSEREQRERERVQHEKEIREMKARAEVAERQRLEKEQLEHEREGRGENDVRREGRGSWRESWKKVVAMGLVYPVHTLSPATAGHDATDPAAQLFSDAEYTHAVSVLYLDESEDGINGVTTRQPEVDDAVSAEVGFDAAEPVVSLPLLTTASSPLTLARSRSTPTLILSACWAACSPRPLCSRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT70</accession>
    <name>K1VT70_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pyruvate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT70"/>
    <dbReference type="STRING" id="1220162.K1VT70"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002162_0_1_1"/>
    <dbReference type="InParanoid" id="K1VT70"/>
    <dbReference type="OMA" id="TLQMWNR"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="17"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="136"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1232" mass="134666" checksum="4D6C8A0D615DE184" modified="2012-11-28" version="1">MPAPPSSSTSNPAMTVVKHKILITNRGEIALRIQRTADKLGIPTVAIYTLADAGTPHVFAAQEAYCIGDGTDPRGYLDMDAIMDIAKKSGATMVAPGYGFLSENATFAKMVEDAGLVFLGPTPHQISSMGLKHEAREVAIKAGVPIVPGSDGVVEDVEEAVKIAAQIGYPVIVKASGGGGGMGMTVCRDEKEMRANFDATREKGQILFKESAVFIEKYIERARHVEVQVFGNGEGHVIHAGERECSVQRRHQKIIEEAPCALFASARGQEVRKRMCQAAVDLCKLMNYRSAGTVEFVLDDTSPELSFYFLELNARIQVEHPVTEVIHPGLDLIELMIRQGMSPTGSLPAEELKQDPLLNIDGHAIEVRVYCENPNAGFQPSPGQLMEVSWGDVGERGRVETWVKSGTTVTPYYDPMIAKLIVWAPTRAECIDKAIKMLDETRVVGPPNNIDYCRQILDTKDFSDSTVTTTWCSRFAYHPPAIEVLTPGISTSVQDMPGRHIGLGFPRAGPADQLSFQAANLLVGNPTTTEGLEVTMSGPKLLFHVDSVIAVTGADMKVTIDKKEVPMWTTLPIKAGQTLAVGMVRHDLGMRGYIAVAGGFRNVAEFMGSKSTFAAAGLGGYQGRTLLMGDLLEIGKAEVKETLTVPENARIPLTNSWTVPVLANAQWDLEYLSKEGMETLLTAEWKVSTLSNRSGLRLDGPRIQWARADGGDGGAHPSNVIDQGYAFASLNINGDTPVLFTVDSPDMGGFSNVLAIANGAAWKTGQMRPGDSIRFVLVSPDEAAQINADDEAWLKACTTSSAKPLHQLTESKDIKDSTKSSVLYRVEATDTTPERIFRQCSDEYVIYEVGDMVLDVQNRVRVELWERAMKEANIPGVLYMNACVRSSIVHFDPSVISMQDLVERMVEIDAGLGSGEDVELPITVHHMPCVPDDKWTHEAIEYYMKTAREEAVYLPSNTEYIARNNGMTLKDVHDTLTCTPWLVLAHGFFVMLPFIIPLDPTRRILGQKYNPSRTKTPEGAIGLAGVIGAIYPIASAGGYQLLGRTLSTWQPWSESHSLLTNFDSVQFYPVSEDEFESIERQFKAGAWKPKSEKSTFKMKDYLAMIESKADATKKFRAQQRACSSKVGEEEEKMFADFLKKKAEDEAAGVKPKTTADFPGEPVTSPLSASVWKVLVKEGDIIEDDEQHVVELEAMKTSVFVAAGDDTKGKKVTGIAVQHADPVNPGMPLIYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTV4</accession>
    <name>K1VTV4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01660</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTV4"/>
    <dbReference type="STRING" id="1220162.K1VTV4"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_1"/>
    <dbReference type="InParanoid" id="K1VTV4"/>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="16" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="15">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="354"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="821"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD03986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="854" mass="93184" checksum="4300515F384C9305" modified="2012-11-28" version="1">MDDEGSNNQEHKALLRKPFPPRRCHKDGVIVRAVQPSSHGSLIAAPAAQTTTSQPPLARHASPARGPPLHPPGQRLWYASSTSPHTPTRPRAEEDSPLLRDWLLRRVALQLLHPSTSRVSCTDIAGRLFSTTPRRCNDVTLTIDGKEVTVPAGTALIQACEKAGANVPRFCYHDRLAIAGNCRMCLVEIERAPKPIASCAQPVMPGQKVFTNTEKVHKAREGVMEFLLSNHPLDCPICDQGGECDLQDQSMRYGSDRSRFNEIAGKRAVSNKEFGPIVKTSMNRCIQCTRCVRFANDVAGVEDLGTSGRGNDLQIGMYIEKSLNSEMSGNIIDLCPVGALTSKPYQYNARPWELKKTESIDALDAVGSNIRVDSRGVQVMRIQPKLNDDVNEEWINDKTRYAYDGLRVQRLTTPLVREGDRFVPATWEHALETINHGLAKSGAKGDEIKAIAGHLADTESLVALKDFVNRLGSENTTLDVTNPDAPIASGVDVRSNYLFNTGIPNVEEADAILLIGTNPRHEAAIINTRFRKMWLRNGANFGVIGEDFPSTFEYESVGKSAADVEKFLKGDAGKGFAKTFAEAKKPLIVVGSAVTEGKDAAAVLKTVSEFVLSKADKFLTPEWNGFSTLQRAASRAAAYDIGFQPSAESSKTSPKFVYLLNADEIDPSSIPENAFVVYQGHHGDVGAQYADVCLPGAAYTEKAVTWVNTEGRTQLGRTAVPPPGASREDWKIIRALSEVVGSPLPYDDVYQLRDRMWDVSPTLVRHDEVDAPSPETLRAGLEALAKADAPSPSNEAFRKPIQDFYRTDPISRASVTMANCSKAFAGGQSPTPENEAREDDKRAAQEDAAKRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTX6</accession>
    <name>K1VTX6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD03012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTX6"/>
    <dbReference type="HOGENOM" id="CLU_804566_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTX6"/>
    <dbReference type="OrthoDB" id="2597004at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37529" checksum="52355FCBAF65F7AC" modified="2012-11-28" version="1">MSPPTPAATTADHPSTAMKIPYDSYPHVIESIVAYSDYETLLSFRATCSALKTTAHKTLCDGELFVSIKDHPGGLDGWVQDIETDLQAKREPVWREVVLRSDKGVLPFRTEADWAFACSHSTFVSIDGGCLAPSLGAARFTMPSPEEVYALRSHTDIDEYNKLVASLPKRSSLAGLHRSLSQITSPLLIQHAWQNPAPVFLPSSETMTLMLDPNCDCGNSEAGLDTTLEHTATEVQVRVTELWDPGFDVPECAVTRAALAPSVKRLVLSARDVQSFAIPLQAILAAREKHNNSPLEIRIELAEDLGEEPARYLGAAYADQFGVPHDKLTIVHEPSAGKAPGMGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU35</accession>
    <name>K1VU35_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU35"/>
    <dbReference type="HOGENOM" id="CLU_1125207_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU35"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852461" evidence="3">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="247" mass="25410" checksum="CB05FB5F9E772504" modified="2012-11-28" version="1">MLVAAFVAIYLLNGAVSAPLDDVLPIGPVQMTVWEVLIGVKRQTGRNCPLGYKLCDDGCAPVVSTCCGDGDGSYCRLVEYCTLGGCCPMLRQCGGYNTETSTHYGSSEPTRSARHPNTEPTSDLPSGTDTFSPAPTSSSSNALPVSGVSEPTSAARSSSSTGQLPESGTSSASKPSPPWAETAPDTTITVVLDPPALVSASKTADYVVPNDLNQPFPGSSGSTSLTVSVVLVTVSLSLTIGFLVHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUK2</accession>
    <name>K1VUK2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PAAF1/RPN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUK2"/>
    <dbReference type="STRING" id="1220162.K1VUK2"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037051_3_0_1"/>
    <dbReference type="InParanoid" id="K1VUK2"/>
    <dbReference type="OMA" id="TYTAACH"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF19">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT RPN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="424" mass="45023" checksum="11FC2F6FE30EB6D3" modified="2012-11-28" version="1">MVDKVKALAYVDMQHDALAVFDDVEQGTVTKEDVWVSVVSYLRQNVSLSQYKLGSPSVHGKVRVESGDGGAHLESLNGVNVERVSKELNVASRPVRFPRQSVKPPYTKKSNVSLSINSIDFAEKSGKMVIGGPDGYCVVLSPQKPEEVLELKGHVGDVLNVKWFPSGEVVLTASSDLSLRIFSGVDGINPRTLKGHTRAVTSTHIIGVGKQVLSGSKDSTVRLWNVGQGAEEKKWTVPDGKFVDGIVVVDDAEGVKTLGGAEGDSIALAASPEGSLTAFSLASESGAEPAFVVQPDIYSNLISIDYSPKLQAIVTGHQNGTIAVRQLKTLRAAEGSIEDVSPTLVMRNESPIYSVVFDDRDDGILVGTGSGLPCRLSLQVDGSGITVDTKEEYGGWEAVGIETWAVAPDGVWCAGGEGGVITRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUL1</accession>
    <name>K1VUL1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUL1"/>
    <dbReference type="STRING" id="1220162.K1VUL1"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="InParanoid" id="K1VUL1"/>
    <dbReference type="OMA" id="AKYEVVT"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38488" checksum="01028520F0DF96E9" modified="2012-11-28" version="1">MTVSNLAQLSDELKKTDFDSIPVIDATAPEFEKRKALAEEIRKACLTAGFFYVKNHGVPESVVENTFKESSAFFKTPDAVKKSVAIANSDNFRGYMGLLSENVSSENKGDYHEAFNLGLDPEVSPESFKKEGNEGLRHSENQWPEKKDWDGAEEFKGTVLSYYKELLGLGQRLFPLFALALDLPETFFDDKTRHPAAIMRLLFYPGLDGREVDELMPGIGDHTGESTLPLHPPFRDSCPRALQVKSASGWIDATPIPNTFVINIGDQFARWTNGVFVSTRHRVLPTLERDRYSIPFFFGCDHDVLMEPIPTCVTEDRPNRFEVMKAGDYVHMRLSETYSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUU5</accession>
    <name>K1VUU5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000228">
        <property type="protein sequence ID" value="EKD04281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUU5"/>
    <dbReference type="FunCoup" id="K1VUU5">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUU5"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_8_1_1"/>
    <dbReference type="InParanoid" id="K1VUU5"/>
    <dbReference type="OMA" id="RSNPMGS"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="80"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="457" mass="52300" checksum="5DEE42B27E7F43C1" modified="2012-11-28" version="1">MAEQYGYEPTNGATPEPVDVPSAEPSPDHHEVAYLNGNGSAGADISTNGIPTPVVVRKTLSSWVGFSNLPNQVHRRSVRRGFQFVAMVVGESGLGKSTLINTLFETKLYQPKVIPEPGTDRGKTVNIESISAEIEENGVRLKLTVVDTPGFGDFVNNDECWKPIVDNIEARYDAYLEQENRVNRLKMTDNRIHACIYFIQPTGHALKPIDIEFMKRLHTKVNLIPVIAKADTLTEEEVELFKRRVLSDIHHHGIRIFEPPQYERDDEETQQENQEIISKIPFAVVGSDQVVQAPDGRSVRGRSYPWGVIEVDNETHCDFVKLRQMLVRTHMEELREHTNDVLYENYRTEKLRAMGVTQDESVFKETNPAAKQAEERAMHEAKLAKMEAEMKMVFQQKVQEKEQKLKQSEEELYARHREMKEALEKQRLELEDKKRRLESGRPLTPEKGTKKRFGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUV5</accession>
    <name>K1VUV5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUV5"/>
    <dbReference type="STRING" id="1220162.K1VUV5"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_0_1"/>
    <dbReference type="InParanoid" id="K1VUV5"/>
    <dbReference type="OMA" id="YSETGHC"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="637" mass="69511" checksum="47A9CFA3837FFB72" modified="2012-11-28" version="1">MLRHAPARATRSARSALRGIRGLQSTPAESTFSLQSQLPRLPIPTLEETATRYLKSLEPLLSAEEFKASQKAVAEFIAPNGLGPVLQQRLQAVDKAAPYSWLEDIWLTKAYLEWRDPSYINVNWAALIGDNGVAILPNSAVKRGQLSDIQVSRAARVISNMLEANEQINTETFPVDKARGAPLDMAQFKRQFGTTRIPKAGCDEIRSEWPCTARHILLMYRDVAVEVPVYNSAGERASTSQIEAQLRDAAKAVDAQIEAKGAQPSVANLTAAHRDHWTKAREHLIRDKHNVESLDKVERALFGVCLDVDVDPSTLDNIEANWAQYAHGNYTAENRWFDKAIELIFLQNGRMGACCEHTPVDALTTGRLLFESLAKEHGEHSSAGASDLAAPQPINFNLDAEDVKSIDEARDGANKLASDLRCLFDLQPAFGAKWIKALGVSPDAFFQVALQAAYYRQHGGTAATYESSNQRKFLHGRTETIRSCTSEALAFSQLLDDSSADAKRKIDSFKHAAGVQNALTLAAGNGQGVDRHLLGLRCQMKPDEAAAATLFNDPAYAKSTTFILSTSNTGAGDLFRGGFAPVTGAGYGVNYAVDPKNIKITISDWKSSNATDAPAFKSTVLQTLADVQKLGEQVMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV34</accession>
    <name>K1VV34_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VV34"/>
    <dbReference type="eggNOG" id="ENOG502SBGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259212_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV34"/>
    <dbReference type="OMA" id="IHKKRFR"/>
    <dbReference type="OrthoDB" id="6288785at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22673">
        <property type="entry name" value="FHA_Ki67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1329" mass="143473" checksum="6A959C07D157D218" modified="2012-11-28" version="1">MAPRQSVAPMPAPAILGHLELIARKTGVKLNGFPIDAERVTFGRDEDCDVRIYVPDVSKLHAEIEFDLETGQAALTVHGTNGLVHTPSGGKPTKHRSGAIIALGDGDQLLFAKKLFRFTYGAGSTSSGYDSPAPSPVKLPHVPGSPGPSEVPSTPVRRRASHRLSIVPQGRRFVPLQPRRSTLGLELPVTADEEEEEEEPVQLAGDEGDTLFVEKRGDEPKIFENAFMTPQVKRKVEPRNTSVVPRRIRFAEDTKRVEEEPAEEPEAAEPPAETNVAEPPSPEALEDAEEEHESPRTPRFVPLPASETTHETPSRTGPQITAQVAYSTPRGDASLRKLLLRSAGSHMTTRERRDRRGSDGDEAEAVEEEDEEEEEEDEADEEHWELSVESSASEADISGDVDDAVPEKTSPGTEPIQLTPPKAPTPQRSPRRGPRVSHTGLSEIGGPAVRFTPAEKPRPVTTGLLTPSRRGLGHPVREMGPDEGESLLWSPLRPAQPEFKAPEVKSNLPDFLMDDDDMPSMTPLKATSLFPPSSDVQTSTPKKSRKSMPETPRGLTPAQRQALGTPRRLGLPEGSFTRAQPATPSATPLKGPELAPRHILTPGTPMDEIKRRLSTLALKTATPAKERRKTLDFAVPSTPLGATARKKRLSNIFDVVEELPSPTPEGTVGEDALADAEEEPEREQPEASPTYALRRTPRRIQQPVHSTPKTTPSKTPKSKTASPVVAGDMYDAATAEADEAEHAPSPGRKTRTKKRPSNAHQLPPMTPDLTGIKHMYAATSAATPALSGIKEMYAAPKEAETPKLAGIREMYAAPKEQATPDLNTKSLYPSLPQATPVMSGIKEMYAVPKEQATPDLTGVKQLYPKLPPPTPAMDGVKHLYAKTASTPALSGVRELYAQPKEAATPALDGVKHMYAQKGASTPSLSGMRELYAQPKEAATPALDGVKHMYAQREAATPALDGVKHLYGKQAPTPKLSGMKEMFAQKREKAYRASVGDFFPELPEREAEAAAAVPTALERKEAVEETEAGVEAEPEAEAEQAADTEAEAEAEAEAEAEAEAEEQPEAEPEVEEQPEPEAEEQHEAEAEGEPKEQKRPPSALSLSSSTGSTARSRLPRKVSAPRPATTAPSPPKSRSGRTEVEVVSKPTRSTRAKSREPAEPTSTATRRSTRQTSQAPSEPPVSAASTASRRSTRSTTAPEERVVRRTRSRQVLGEAEQPRAPSPEPASAPSKPTRSRAKSSADEKPSTRAKPATEASKPTRSTRTRKAEPEPESKPTRSTRSVSGTAGSARGKGKEEGKEEKPTGLRKPVVRTKENEAPAVAVAGRTRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV81</accession>
    <name>K1VV81_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000336">
        <property type="protein sequence ID" value="EKD00653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV81"/>
    <dbReference type="HOGENOM" id="CLU_1526238_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV81"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="176" mass="18768" checksum="2116BB8B7DDD369E" modified="2012-11-28" version="1">MKKPQRNQAHDLAKYPSLPQVPALEFGRGAIAAGPPLAASCLRPTHCPWALFAHGASDTLTSPYNLQALPPPVPSTTHRPIVGPNAFASSEGLRPFFPNVANANPRAVCPSKAEDMTKVRKVLFARSGRGLVGLRSTAPSLRNRLKCLRAHDQRNALVSNQVSSNRSPEVGAGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVN0</accession>
    <name>K1VVN0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVN0"/>
    <dbReference type="HOGENOM" id="CLU_934426_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVN0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="298" mass="34628" checksum="A7D970A7D0A3ABA5" modified="2012-11-28" version="1">MRNWHNVIDNVWTPWDTFPNWHSAYSFGERPSPYTGPSVLYIDSSPCLTRGVVRYQADPEAPPPAPLPGVLSRLFGRRWTPSHPIYFTSFIWYDKGGYTCECTREELCRAFHRLVGDWQELFTLACAAWSAWEAPFLTYWGQELDVNCPQVRGRKNQLYHQIIRDAKRWSACATELWREVELFAQYLSRFARMESSGEMPHAFSRYPGKVGCKLSARFSRPVRMKKTNDIDDWVFRFTKIINQYESSWDKLHGIHSMKAVLVKIRTDILNAKGYGPREGAKHLNAVTGVRHVPPPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW18</accession>
    <name>K1VW18_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW18"/>
    <dbReference type="HOGENOM" id="CLU_1180926_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW18"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="26269" checksum="9DEA8670D3412CBC" modified="2012-11-28" version="1">MSHYSRPSQPQSVPAFAYFAHSPRAMTELKNQDPRVSSLYKIPSSAPRHLRWKKILRTSNPTTPSIDELFTELPEQTAQLARSGPNASPSSSNSKRKRLLEAEEDGLASAHRKVHIMHEMLSHSSSSSTRDDGLDPGAEALARLLTFKHDAEDKLALAAAEKNILQRRKDALQAEVRQLKSALLASQVQVAEKEKHIKALKTYLDDSPNEKIKELEDKVDTLERQNAQHVLAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXI0</accession>
    <name>K1VXI0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXI0"/>
    <dbReference type="FunCoup" id="K1VXI0">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXI0"/>
    <dbReference type="eggNOG" id="KOG3095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824354_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXI0"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="37857" checksum="4C7DCAA6B9E7F119" modified="2012-11-28" version="1">MRFPLRLLRTPTRPADPQPQCNGSMSNLLKRKSPYSAAGSPAPNSRGATAGVSVKTEDRKPRAMPVAGIIELVRSPCRRDVGEIGGRHFLAKRYYKELTPGIGGTPSGSHYGFQDPRTVSLELRDYLKDRSTLRWQDAYLHVEDKSPGVDPNQVLEMLKGLDRVKFNEHNQVFTYEGLTYKSIREAMPGPELVAYMEELEKDGSILILRSLTGKLKDAPLPALGKENAWGDKLNGGGPERWRTVFWDELKERGRAADRVDDEFVFAWDDVKIQETDDVAKLLEGQDLKASSVDKVDNKPKNEDQGKKKKKRSRALKITNTHMKAFGIDFSQDYEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYM8</accession>
    <name>K1VYM8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYM8"/>
    <dbReference type="HOGENOM" id="CLU_2063126_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYM8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854458" evidence="3">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="119" mass="12842" checksum="B57843C9327C36D6" modified="2012-11-28" version="1">MFALLIPTALAILPLARAEWEWTAGQTAWVVVVSVIGSFIILSIIGTCIRSAYLANKMAEQFQQYRPPPPLQQNVYSTDPYNPNTTFAYTAQPNAAYPPPPPPAAGVPGKTGPPIYSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZR3</accession>
    <name>K1VZR3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZR3"/>
    <dbReference type="STRING" id="1220162.K1VZR3"/>
    <dbReference type="eggNOG" id="KOG4406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842473_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZR3"/>
    <dbReference type="OMA" id="ELWIREY"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="88"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="34382" checksum="393B0D191314D91F" modified="2012-11-28" version="1">MSPKAYAKLFVVPSLAALTAHGVSLRGMDLSITTLLEEAAATRDPPASPSTIQWGFSALTSAVGAATSYLQGTQAKAPTEPSDPYWGQDIDDIVADARGVPRVIEELGRAIYKECTGTEGIFRRTGNSPVLAGLRSVLNAPLGLQPKVDWALVAAHDPLLPPTLLKRLLSHLGAPIIPASVYPTIKSVRTPAEIRSVFLPALSSGRATLLSHIMHVAHHLLPSEPTTRMTAHALAVTLAPTLINGPDPREDAALCLAPGQSLPGLGVKADEQTLVGLLEISIEKWAEVNGESPGEVCECGLGGKEAPPSPIALGARGGQTRSSIAEPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1C5</accession>
    <name>K1W1C5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1C5"/>
    <dbReference type="eggNOG" id="ENOG502RB7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855772_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1C5"/>
    <dbReference type="OMA" id="DEMWPED"/>
    <dbReference type="OrthoDB" id="2596726at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="36288" checksum="6E1F1419A6584657" modified="2012-11-28" version="1">MMSDEMWPEDEEADMKRRQDEQPMSAFVVIRELAEYLELTSVYVVFFYLVWQILTRSDENEILSHLPSTSPLRGQQGLAVEHSASQQQPYQFPYALPHIPSPIRDMEAAAASASSSTWRTVLQSILYPFYFLLTLAVIPLPFLNQALTLIMSVVGTIIYPLTSTTRLLSRTFIVAPLQVVQGLFQALYPVYVFVGGVLGLGCFLGMSAGWIGQYSLDLLLTRKSPKRKTRRHKTKKHHSHSHSSTSSPESIDASAAVERSVAAAGSPRQPRSPEIRTFHGRYVPVADIYDDRDFELAGSAVKAGRSSAREPVVVGIRRRGMRSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2E5</accession>
    <name>K1W2E5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2E5"/>
    <dbReference type="STRING" id="1220162.K1W2E5"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424002_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2E5"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="448"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="646" mass="71277" checksum="8251A5673986641E" modified="2012-11-28" version="1">MSDPKEEVATAAAGTSVDVKPGITSPAIDGDNKTVTKHGLEDTQVAQDSPSKKPRVEEASGNNKVLPTPPNEASDAIAKDPGAKALKPRIKEVYEVPLGRRWVKYVRPPAPKVNGTWRVLVAHHRAADGDLLEKFLEIDTFLEIKHAGLREWLKQRYPSCLKLYDYPPGIRRAWEGLEKDPSPAAPGDNKEEAPATETSADMTEDDDCEDDSDSDDKIDAESDSSDESAEPTGLQTALGVLVKYLDDKAGSHRVPSAVVDLHSGPGSVHDRQDDRLAYRLPLISDLEVSPLTPEGKVALADRGRVYASKYASIVHASYTGSMYVMNPSTGRYHARPGSGRVIVDVGTHRQDYPYEDNYGEQRRSAPKVTLNDKYLHLLPPSIKGFHLKHKIWGQFVITRLQDIEWNDMAFKHLVISDTYRNIVQSLCDVHTGTLGAGLVKDIVPGKGEGVIMAFHGRPGTGKTLTAEAVAEHLKTPLYMVSAGELGTHALERNLQNVLRLATAWKAVLLIDEADIFLQRRSSTDLERNTVVGTFLRLLEYYNGVLIITTNRMHDMDEAFASRFSLILPFEDLPPASRRQIWAGRCRSELEKPEAEFDLDELAAANINGRVIKQVVRTAQALAVAAGGSLQMEHLRQVLRLTDCQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3H6</accession>
    <name>K1W3H6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3H6"/>
    <dbReference type="FunCoup" id="K1W3H6">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W3H6"/>
    <dbReference type="eggNOG" id="KOG3438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_1_0_1"/>
    <dbReference type="InParanoid" id="K1W3H6"/>
    <dbReference type="OMA" id="IHLRVQM"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="8">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="162" mass="18594" checksum="54D7906EB7E1F8AF" modified="2012-11-28" version="1">MSSEEQRQKEEAASRRHAKLDNAGVLHMSTQAEIPDKITILPGHEPDYSACTFCLWEEDHTLGNALRWMIMKDPDVEYCGYSAPHPSEPKIHLRVQMYEGLSAVDCLRRALSNLRDLYETIGAQYDRSLKTDKYVKEKDVDVHRVVAETLRERLGEDMDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4N4</accession>
    <name>K1W4N4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4N4"/>
    <dbReference type="HOGENOM" id="CLU_1200549_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4N4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="entry name" value="SO1590-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SO1590-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="269" mass="28276" checksum="F7872B5532A8D027" modified="2012-11-28" version="1">MSEKADDPTPSKPSDIGLADEPEPPIPPTSAASSGPSTSNPSQPAPSTSTASAAADVPEPEVEEETTPTATNPAPPSVEVEQVDITEDPEDTVSGNGQQVKASFRSASWKSVTPEFTAPLPFQSMIIIEEFDVEGAQWSGKAWQMVTTCSLIPLSAKNGELASREAGTLDLPLTPAATRMLANARSTATDPTSWFYSGELVFQGTIRGRKGKCIFRSTGSVSTADGLDGTLELIPETASDELAGLRATSTCKEKEVAPHLPIRYTLTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W506</accession>
    <name>K1W506_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W506"/>
    <dbReference type="STRING" id="1220162.K1W506"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_1_0_1"/>
    <dbReference type="InParanoid" id="K1W506"/>
    <dbReference type="OMA" id="LKKGWVM"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="30815" checksum="46BEA798C88743A7" modified="2012-11-28" version="1">MAFATPSPTLFVGNLETKTKKPELRQQLYALFTPYGRVGDMETNGCTRWADYSFGSTAIKLTGRIDIVAKKHDGGRGQAFIVFEEQAAATAALRGLNDTQFYNRDMHIAYAKNPSNATLAREDPSKSKEARAIEAARVTISKAQGEYEQLEREKAGGINSKRAPDADVEDRASKKAKTEDDDDMEIEMEDDDDVNVSVLCSNLPAECNEAIMGALFSHRYPGFTRAVEINAATPLPPSHPKPNAGAKTFRATFASRAQAEAVIKPLSGYVMQPGWDMAVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W663</accession>
    <name>K1W663_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W663"/>
    <dbReference type="STRING" id="1220162.K1W663"/>
    <dbReference type="eggNOG" id="KOG3834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025095_3_0_1"/>
    <dbReference type="InParanoid" id="K1W663"/>
    <dbReference type="OMA" id="RVNITIW"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="182" mass="19943" checksum="0487230B013554C7" modified="2012-11-28" version="1">MGQTASSTPTALPEIALHVLKVSENSPADGLLEPFFDYLVGIQDGSGKQPGQEVPTPRELQNILERNQGREISLFVYNAKTQRVREVSLTPTSDWEPTDKAKASLLGTSVRVCNPALALENVWHILEVLESSPAEMAGLVPFGDWICGWAGGPLHGENSFYDLVEAHIDKPLRLYVYSADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6C8</accession>
    <name>K1W6C8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6C8"/>
    <dbReference type="HOGENOM" id="CLU_602948_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6C8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="311"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="407" mass="43821" checksum="7B2625AA416FC9CA" modified="2012-11-28" version="1">MSNRVPWQEPAMLNQAGARPSERTEQCASRSQNDERRSSAHTAGVEGSFLPSTLSTLESTASQHTPAVSGPPSVSITESRARSSQLKPAVSHPGRRQCKLELRPAGRCHSKSHDNHPNEDERCNIPDGVESEEDSVYRRGPALQALSRRLAAPPKEDNVSDAEKLSARAAARLLAVFDEYFNPGPISFPPQKTGRDGSVLLAPVGFVIRPHGKPEDGFPLGPKAVRAILEREVWQSLAIDTPNIPETLTFKPGGVTHPFSVQHANRTLRRLPSLFAQTPTHLLQDTVEAVADSASAVLLSRGNIPTRASSVEAGLRASPGVGEAVVIAVPDAAGQAVVAYFSSTKSSDTFSITELVDELKFVLEQHSNATVNAAVLDSLPQPDDGNSDRRQLRKNIKEFGDRKPTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W983</accession>
    <name>K1W983_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FmHP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W983"/>
    <dbReference type="STRING" id="1220162.K1W983"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341690_0_0_1"/>
    <dbReference type="InParanoid" id="K1W983"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="830" mass="90240" checksum="7D111FAD3723B781" modified="2012-11-28" version="1">MADGGTTAHHGSSESSGSVALDPAMIELVEKLSVTPEPLTPLTDCQLADIYASKRRSSVPPFPPQLELQHLSSTSSSTASSQGELTTPVTMLFPLPPTTAAGAAGRPPPLNLSHGSSKESQPAASGDMGAFEGSTGSGGLLTLEIGDQFLSPTAHSFDFDRLTPTSTSSPTVSSLDKLTVRQQKSSSSLSALSAKSYPNGLLSPICVDTTAAAQQSEWSASAHSSAGDHTTVGDCTTSSFGHSPTSPLSPLSPPPPLPEKDSKYRSMVMFGRQSFGVHGGKDQEQAITSVLDDLVEEETNESDPETSLATHFPEKRRSIKDVEEIMADDLNDLRDAFLPPETRSRSRTVTSRSATRTKSVGTFKLLGTNKPVPGHGTPSTYTVKSGRKMGRRSSSINGTDEKLLEIWSAPPLLAVVEAETSIVRDENGRAVHFGDLLPKGVAARQGAGSNDSPKVVVIFMRHFWCPLGQDYIVRSISQLDPSTLRSHNTQVVLIAPGSYKLIKKYRKLCQCPYPIYSDSTRHLYKLMGLSDFLGDDKRYHQQRQNTSSQTLKSLRNGFLKLPGDPGSARQLGGEFIFGADNVCEFAHRMTTPSDHLEASAVLRTAGVEMPSPLFRSGSTLSSIGNGIVCIDKERKGSWETSRMSDVGSASDMKRPTKLERESATWDEDTEEYVESLGPMSSTSSSHQHSTSAHGHQHHAPRRSVDSPSPVQEVQMEPNSPTRPVKSPLRASMYQQQLQQLQQLQQQQTQNVQTINNHYNSFAEKRERDKPMSTWSSSSSSETGIVTTPQQQNLPPIHPLDATSSEQKDKEYEELVRKYRAQKWGLAYEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAX3</accession>
    <name>K1WAX3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAX3"/>
    <dbReference type="STRING" id="1220162.K1WAX3"/>
    <dbReference type="eggNOG" id="ENOG502QQGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="InParanoid" id="K1WAX3"/>
    <dbReference type="OMA" id="NLAWWID"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="412" mass="44969" checksum="48189687C87A5B58" modified="2012-11-28" version="1">MTINATPKLSEEARAALDAVLAKHLMTTPAVAFGVTTKDGIIYTGYRGDRVYSKPEEGQVDETTTYQIYSMTKLVTSLAVLQQVEAGVLSYDDPAIVQKYAPELVKQRILISYDEETKEAKFADLERPPTVRDLVTHTSGQVYFFFDPKLYAYDRDHGLLAMFGSETGQFAQPFLFSPGTRLAYGTGLDWAGIILERATGQDLESYFRQHIFDPLGLSQNTTFHNTPEVVAKRQHTVFRQPDGSLVLGKPQRPIDVEVKGQLSGGAGLWSTMDDYLLLLRGVLRAKQPGGIVSPFGFELLFKDALPADTPGGPQCHAELSAFLEVLASFSSLEHPASVGHSIACVVNLSDTKGRKAGSGAWGGAANTQWCIDPTTGIGIERALVSGLATEMGTEPFAECWKELEQVLFQHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAX7</accession>
    <name>K1WAX7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1WAX7">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WAX7"/>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001222_2_0_1"/>
    <dbReference type="InParanoid" id="K1WAX7"/>
    <dbReference type="OMA" id="IKRYHIT"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="192"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="512"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="619"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="518"/>
            <end position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1440" mass="161312" checksum="825F3249D918C39F" modified="2012-11-28" version="1">MGHGRRAWVVGGGATRNARRPDQREAARSHGQGEPPGSQSQLTALEISRPCPSAVADRADEAEREPYADPHEARSGQGQVARWCTYDLRQNHIPLPKPGEPEPTLMEEMAQREEAQRAAEIAQAEAERERKRAQALEQERLLKERIQLDATRKEERARKVQQAEEKKERDEQLSGLADGELEDRELVLDQPISIDGYVGSWSNWALFGGRREGLWTSYIAEPARSGRDFVKSSTPSVTVLIVDFSRQYYHTSPGKKRIEVMVTEIKRLQSVHSAHVAKVYAVHWCKSPKGWERLAVVIERIPDGGKLPDSQDYITQVLTGLSDLHRQHATQRHLILVSPGAGGDATLKLSGTSYARRIIEYHRSNPFLKLSPEEIDSPYSYTGKRDVWYAGLILLQLLFGRNCLWIYPNLQTLLAHGGVSPFMMELLTGLLNPSHKRRFTVDDALTKLRSPEEETTRRPGRPIPRELAQSSCRANVHQFDLLGKSPVFGKGLAQYFPTTPTGAHPSRYRQDFEEVEFLGKGGFGEVVKARNKLDGRPYAIKKIKLRPEDNVNRVLREVNSLSRVSHQYIVRYYSCWLEEVGPPEPQMFDDMTASTTTSSHVSSEEDIFAVNFDDLSVSRRDQSRSASFPRIRFTAGSSDSDDSDDDDDSNDDEDDDDTDSDDSDGTIPDPSASGQRARGKSGSKAVSVPSRPSGSYTGTTTDDASFQRILYIQMEFVEKPSNILLDTNGNVKIADFGLSTSDPTAGDGIGVMPSSNDIDKTSNIGTSLYIAPEVLVSKSYNEKTGMERVQTLTALRGPEVPFPTSWPVDLKPKQREIISLLLRHDPTMRPQAAQLLAGPLVPSPDKEQKLYDNVITEITNPRSEKYPELIDALFQSHKHQFNIDTRLDDFTYDNDHDDGHHIWLTVVIKRVVDLFQRHGAVDDYLPLLVPETTLLKAFPDLKPVRLLDQNGKFVQLPWSNLLGMARSASRRQLERIKRYVVGRPDTSFDIVSPLRSSVAEAELLEVLDKMVTECQGTSGGAQFDYEFHVSHESVLATILADVPAQCRPRLLKAFRGSPASVSFEARSTLQNIPGLPKSLLADLQNISGAGEFEQVRRTVENSFTSSRRKLAAALDEINTIIKFARACGITRKILFRPTMAKHAEYFRGGFMFELVKRGKHGDVLAFGGRYDSLLEHFKEPARQSLKVYGAGMSIAVDNLTRTVRKQESLVSHRLMTKNREEERSFGLWSPAARLALVGELWKAGIRADLQYDDGRSQDEVIEECKEQNILELSDYLRSAITEQRRIDSSYADGLPLNQKDVLSKAPVEAASKPDAEIKLVLPPEPLTSRPVKGKPVRKHRHVTKAVYYDKAADFAVNVKSSLPVIGVDLSAEMLSAMTLDTAWVRDDDAWRAITHPQLPTSERRYADQVRDAVREHSSSTGGPVWLFSVREARGFLLQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBU6</accession>
    <name>K1WBU6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBU6"/>
    <dbReference type="FunCoup" id="K1WBU6">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WBU6"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004190_2_0_1"/>
    <dbReference type="InParanoid" id="K1WBU6"/>
    <dbReference type="OMA" id="EDMRIGP"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated" evidence="6">
        <location>
            <begin position="597"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="707"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated zinc finger" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="878"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="883"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112546" checksum="262FE8E647547EDB" modified="2012-11-28" version="1">MGSHALHPLITGTKTRITALHQHGDQLYAGCADGSLRVYSLAELEDESPKLLETHQVGRRQIDQIGVLPEAKQLVVLTARTPHAIATTTYFAPGSAKEDGGTPGKVSKDLLVIGCRKKVLVYGAGKHLGEAWELSLPHSPRTVIFPAPFYADLPDTVHLLYSPQSSVLLHISNGPAAASRLSVTELPTTGYPPTAGPSDAKPGHEAGGGFGSAFTGFGGMLSKAAIPAGTRTVGGEVLLARDEGRFTRGESLQWPATPDLLAFGNPYIYSVLPAAASVGSGSTPPLPSVRVHLAPTLTLRNVVAFPTPSAGGLTVSAISVSSKAGPQGPSLAEPKVLLVSTPTDKTLLNSEGSTVWEMRTGDVGDAVDELVKEGRVADAIGLVEASGDAKLAPLSHLRVLQAVSQFARGEYQPAIETFIAQNVHPAKVVALYPQQAVSGNLYVPREDWMSLFGAVEGARLEPPEPPEPAPEPGTSVPKSLFNAHLSLSRKKSNETIRSVASTAKDDRSPTPDAPIVGKDVPGNSTEISRAAIDELIYFLSDRRQKLAGAIPALGKPLPSETDMVPLSDMPAKEVHELPDVPMTELNAEQLLRTAQVVYTSLLKVYLVARPTLVGSLCRIENWCDVAEVEPLLREKGVSSSEVKNMHDKALSMLYEQAQPEDDPLDRYPPTIRYLEKLGPSHLDLIFASAKWIFREDPQRALQIFTADEPEVDALPRAKVTAFLELEHWPSAVKYLEHVIALGEQSPDLHDKLAELLLRSVREAQKEQKTEVEGKALGKLLEFLSTSTRYRAYRILSQLRGDGKFSKCDLQLTSEMPRARALLQGRLGNHDAALRIYVYDLGDYQAAEAYCSKVYAKDPDPKGIYLHLLKLYLAPTPGRRSSMSGRTFSPPPSSRGTSRPGSPPVTSPPAGLSAEPLVKPALELITRHGLRIDSDAVISLLPPMISVSDVQTYLSKQLKATHSALAAHRIQKELVKSRNVQVKGMVLNLEVRRVKVDDQRVCPQCHKRLGQSAIAVHAPRGQVTHLHCKDQFSAWLNRQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCU4</accession>
    <name>K1WCU4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCU4"/>
    <dbReference type="eggNOG" id="ENOG502RB5M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330990_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCU4"/>
    <dbReference type="OrthoDB" id="2591172at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="866" mass="92032" checksum="1927A67EBE71ADE5" modified="2012-11-28" version="1">MHRTEPSGDPSDQRDDLSSQGSGTASTPAQRGYLAPFFPPQTGSPSHRSGASTAPPPVVPRVPSLPSMRPTQLASRHVSGAQYARAYPQYAMTPGFSSVFPTNANNLYQQPAPRVVPTVPSAISPLSGHPMSAFAHSLEQTAAVAAQHAQQVPLFPFSSVPQIAQQLAPDVYSLSSGSEPSSHGASALPSASSMPTAIEVSVPPVGDFAVDTALLTGNQQRSVSMPSLRAHPEFAMSQVMASPQGQQYPVSPTGSDIRRVSNSLRPSGAPVFKPYYPSSPPPPRSAGYASFPAAAPSGSAGVSPVAISGPKHMVQGAETWSTSSTDSPPSGHLSSKRLRFAGQHDREARAVSSKISRDFEYDYTPTPTPPMRSPHSAAEPFAVVESDEDRPVTDDGRDSDFVPPSNLSPRKRGRAPPRSLQPPPKRMCADNALVALFEKYPSLPGRFPLFCFALEHNLSFHEPSVPMIKSLSQALSPLQKCEELKKLWHKGRRILAQLDAFVARCERKVIRPGDEKLPELDYATRRCNPPGAQEDCRTLHIGKNKWEPIETGMIEWFEGMANNDPANDLGNFRPPSPRNLAPGSSSDPPAAPSHAGAPGSPDAQSEVTRKAYHHSQALAPQIPQLSHQRSQPSDPDTSYATREYGHLHPFARDFSNQNHSNVAPDSAPYRGASSGSTLRTSAVPQSGTSSLSANVSPKTPLSPTALSGPSGVEGNSVPMSNSVVVGSLDGFPAGTGPVAANHSAFNAETGGLDSSFVDGPTFTNQRALSAQDIFFGSESSNYSRPASNHSQYRADESLQDLQDCGGSPGHPGPQLDNVVRVENSAVVNPPPRSPLEPEDAHEWPGMPDMAFTSDYSLFGLPNYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIL9</accession>
    <name>K1WIL9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">19 kDa protein having G-X-X-X-Q-X-W motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIL9"/>
    <dbReference type="STRING" id="1220162.K1WIL9"/>
    <dbReference type="HOGENOM" id="CLU_1732781_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIL9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852900" evidence="2">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="19682" checksum="257301965103DF09" modified="2012-11-28" version="1">MLALLTSTLLLLSAVHADKASIKWSNVQKGSYGLLVMPKPNGYFDFPSSLSNGMRPHIVSIYWLPVWDFNTAGEITKLKSDPKFGDFCLDVEPDAKNGTPLQIWECSASRPSQDWIWKDGHLKHVCSGLCVDVKDGQTGQTAQLWECFDGNKNQQFEIPADPWLPQGDPPRPSPTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJF9</accession>
    <name>K1WJF9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJF9"/>
    <dbReference type="HOGENOM" id="CLU_2559926_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJF9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="84" mass="9135" checksum="2AD59BAB9B65FE60" modified="2012-11-28" version="1">MARSAQVSQAKAGVAEAVAAGQQGTQAASTNRASDRSITAIESQNDPRQRTVVEMKRSMRQKRAALEWAFSRGWSEASRADCHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKB6</accession>
    <name>K1WKB6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKB6"/>
    <dbReference type="HOGENOM" id="CLU_1403343_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKB6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="194" mass="21414" checksum="3F978251E9589159" modified="2012-11-28" version="1">MMSRRRVSGAKVSKPVMLYNTVDPVGPEFVPRHAPKVPSTPSSISSVPSTPDPPSLSSFENPLPLDECEELLDDYDPIYEKRREEAYLASLSSLQGSRQRSRATSHTSSHCQSGTASTTDSLSRRLSTISTASKLSKRRTLRLSKSVPTLAAPPVISHPMPLGAARRIRKVPSLQQVERKGRLSALPRMFAWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP42</accession>
    <name>K1WP42_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM32A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP42"/>
    <dbReference type="FunCoup" id="K1WP42">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WP42"/>
    <dbReference type="eggNOG" id="KOG3410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098435_1_1_1"/>
    <dbReference type="InParanoid" id="K1WP42"/>
    <dbReference type="OMA" id="RMEVMER"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19410" checksum="2C466D7857A832A9" modified="2012-11-28" version="1">MSDYTVHRPGGALKFKGDDGKKKKKKKSHSSSSLAAEGAAIETKREHSSKKDSARDREVREDSKDRDSRRSSAAPTSASASPAPPPSGPRKTAAELRYEEVQRKRERARKTAHQTHKDRLNDYNSKLERLSEHHDMPRYGGLAKRPQAGALIVVTPLSTISSSNWQRKSVVILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WR26</accession>
    <name>K1WR26_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WR26"/>
    <dbReference type="HOGENOM" id="CLU_931225_0_0_1"/>
    <dbReference type="InParanoid" id="K1WR26"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="299" mass="32671" checksum="14798019586AC5C7" modified="2012-11-28" version="1">MPSRDFQAPRNEISPDTPSPNADPFLSAVQDLHHSDESNQITSARGLSQWERMERDLPEGLSDGHAPQSATMGDAVQRGASRPSPESSSMIRKANAPFTSSMSTSGTGAVDALLNPDVPKMTINTPQEPRTFVSYTPGPPSDTSEDVTDTEALEDLLNPDVPKMTINTPQGPRTFVSVRPRPPRNAPRGSTPARGTAPLRALIMRRPPGGFQPIVARRVWPSQNSPYSYEPVDERWNEYIESPSRSVPDGVRVALSPSSSSDPLAGQHAAPGCRNQTNLLQHWRDALFPREVLNERPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRW4</accession>
    <name>K1WRW4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRW4"/>
    <dbReference type="STRING" id="1220162.K1WRW4"/>
    <dbReference type="eggNOG" id="KOG3458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081931_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRW4"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32809" checksum="974CBA6A2A7DEA29" modified="2012-11-28" version="1">MSTHREAVRNDQPYSDPNPMPKSVPHVDELGTTSAPLKSASFFIGDYCKEYNGKCQRKPLRRGREKEGKGTAERDGTTAKAASTTETPVGIDRISICAIVHERSYARTLVGLSWESDAAVCQGSVACTSALSGVLVLGVPSDRRGPECLVSRLPNLARSGFNSNAVGAVRSASPFPRLSVAQQPGRWNVANPTEDFMLCKNENRDPEHCLAEGRKVTRCAQAVITKLRENCLQEFDNHWKCLENNNQYLHACRKDEKKFNDCVFAKLGWKKNIPGSPEGEPQVFEKKNPIYTRVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WV60</accession>
    <name>K1WV60_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exoribonuclease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WV60"/>
    <dbReference type="STRING" id="1220162.K1WV60"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002512_2_0_1"/>
    <dbReference type="InParanoid" id="K1WV60"/>
    <dbReference type="OMA" id="IMDVRFN"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="474"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="955" mass="104117" checksum="B9736C68E629C29F" modified="2012-11-28" version="1">MRPAILRRVAVASQRRLKSTAASQRSAGSLLADFDALQAKRPGAKAKKSKSKAAVVPESAPEPAVRTAKSARPEIKYKNSMVTKSQERLAFFAGDEVDFAGGDIEAAEDVPGIEVGRVVELRRSYMTTIGVVLATIMLDGRRRLLVMRATGEIWPAVESDVTFVMPPSLIPKEVSAGCWSPQLLQLWATGQDVGMASASEQSDLLGRKEAEAMADCRRQASAFLRKVQRETERMERHLLAYGVGGAEGIWERYADDVERRTVSAHEVAMTLLNLKRPIGKNTLPTFAAHCLLMRKPECFVADERGVWASGRYLVRSRRERELRQRVRDRVFSDAPEMRAFAKHAEEVRASLAADQPAMEWEDADREFLHVLTLPMVETRSTQALPAGPVANSTLKSLGPTFREAGKKEQDTIDQADYVATLESVGMIPASDSLRASIVRESAERAAAIDGIQLPVNPAGRDGPTESDRLLDGLREDMSSPAFVIDDAGAKELDDGIALERVGDDYWIHVHVADPTRFLARGDALATQAAYMGSTLYLPEGTVPLLPHEMGKGAMSLGSGDGKGQPTLVMSALVTADGDVKDTRVRLGWLRTPRITTYSAVNEVLGVQPPERRYPFGRNPALSGSEERDVAPLSESDAADLRTLQSLACKLRAKRTASAGLEWDQPYSTFFVRSAPPLTNIFNPASIPSQPTAPQPFEYEYAVDQLGMSLPSAQMTVAELMILANGIAAQFLSDRGVHALFRGSLPPRVTSRSRSTVEDLLAKRLPGTAVLPPGEVEKAALLWSQATVTPEAREAWLMGLPAYLRATSPLRRYDDLLAHWQIKGALAADAGIADASLKPLEKKEVERELFRATHADRRAKRSNQDAVDYWRALAVRDELRDPALMDNERGRVDLTKPITVRVRDGGGMTHAAAFSPDLGGGVSVETDHALPIGEEVQVKISGGLTWPKAVVTAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WW44</accession>
    <name>K1WW44_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000160">
        <property type="protein sequence ID" value="EKD05014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WW44"/>
    <dbReference type="HOGENOM" id="CLU_1961136_0_0_1"/>
    <dbReference type="InParanoid" id="K1WW44"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="128" mass="14289" checksum="DFDA5A15D2ABA401" modified="2012-11-28" version="1">MSEGFSAATLGDTLVERDQETTRLQQELIGAERSLATMTLSAAGHATEKKGMEEQLEETRREAMDATDQLKVAIGIVVQLEKEKDVDAEIIKKLRMELMLLRCHLRESESQLAALRGEVKSSDDDIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WX07</accession>
    <name>K1WX07_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WX07"/>
    <dbReference type="HOGENOM" id="CLU_641212_0_0_1"/>
    <dbReference type="InParanoid" id="K1WX07"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853139" evidence="2">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="428" mass="46887" checksum="80C9ABC85D612B81" modified="2012-11-28" version="1">MLLKTVFLTALAALAVAAPNPNPEPEETTLEERNNWGWIPAIYARRQLHPNCGIAGVNCGKSGPFWFCAPFRAECCKASIVLSTRDNDGGDGGDGGDEKPADGGESTALIWPPPIHRKTYCPSGVAAGASLTGVAARRPTRLVQAGRWTARRSEDMKLSSQCGATLERRDQVITSNIPSSLAAAVTPRSAGVGGARLYNGAPAAARHRPFLLRRTSLFLAARSSSTPTKQLPLLPIVMFTLCKWLPALLLACAFLGVASAQSQNPNQKAKLHTIANPNLCVALGDGTYNRDIVLRPCSHELATWAINKNEGKTFIRHINQCLNGAYFALDWGFNVQNGNPAYGQLCQDEALRYAYDLWQEGGHDPWRWERLSTGQFRLFGFPLNPCLDIKDGRVQEGTKLQIWDCHPQGHPDYNNQKFNIEWLGPEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0L1</accession>
    <name>K1V0L1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0L1"/>
    <dbReference type="FunCoup" id="K1V0L1">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V0L1"/>
    <dbReference type="eggNOG" id="KOG1662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0L1"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="26851" checksum="F58AA6454453A49F" modified="2012-11-28" version="1">MASIARNVLRRGYATASSVKRLGWSFGRKLLPDLGTVDGDEKRMHGREVDTSALGCHAARLQPPLQLNSLAGTYASSAYVAAAKQGKKELDQLAEDVTSFSKTLRDDAQLKAKIDNPTLSARERSEVLKQVVPSGSSPILFNLLNVLSENGRLGSASKVFEDFEKLMSAHRGELLVTVTSAEPLDNKSMSRLEKALKGSQVGQDKTLKFVNRVNPSVQGGLLVDLGDKTIDATAATRVNRFNQALAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2Q5</accession>
    <name>K1V2Q5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory subunit of acetolactate synthase, Ilv6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2Q5"/>
    <dbReference type="FunCoup" id="K1V2Q5">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2Q5"/>
    <dbReference type="eggNOG" id="KOG2663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2Q5"/>
    <dbReference type="OMA" id="CARSGMM"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="84"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="327" mass="35502" checksum="7B28004A83DA19BF" modified="2012-11-28" version="1">MLSLRTAASRAAGVRALSTSAARMGAPKPIDDSTSALDYKMHRPSARLPHLVRAHPRAPSAEEAVTNILYNTPPPSLEPFKRHLLNCLVQNEPGVLSRVSGILAGRGFNIDSLVVCQTEIRDLSRMSIVLRGQDAVIEQARRQLEDLVPVWAVLDYTNTPVVERELLLAKISILGPEFADAQLNPSAGEELAAREENLVRHFEAKGSNPSGLPEGVKEPELYPSRRREVTASEALIAKNLHLSAIKTLADQFGGRVVDVAEESCIVELTAKSSRVESFLGLMRPFGVLEASRSGVMVLPRTPVARLTEDEEVVVQTDSPDMSSLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2U3</accession>
    <name>K1V2U3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_07531</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2U3"/>
    <dbReference type="STRING" id="1220162.K1V2U3"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288722_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2U3"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15526">
        <property type="entry name" value="PHD1_MOZ_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="574"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="802"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="876"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1025"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKC98199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116818" checksum="DF8281F0AF25EDEE" modified="2012-11-28" version="1">MQSAAGIGFVQVHRRPTLAAQYRARVNQLSCASPTQQCHPWWFVLGNPRSNPIASTSKALMATPTRRASSRSAPSTARSSKSQPRNAPPSSPLAHAGGDIVIDPALLAEDEALQDDLDAEGEVDDGVGYYLPTDDYFYEQQTADAYSASPMAGVTTPMYSDQPTASSSSYSLPPVDYDLVPALPAPSPLSTISNGHGNAKKKRVRRKANGSSTPKPKPKTENSTPVPTTPVNGAPVVIPPGTCPMCLGTEKRNRDGKPEKLISCVSCGNSGHPSCLGHTNAAMIKKMRSYDWCCIECKSCEICKIKADDLKGPPQGQWFCPLEPEPSVPEASNLASPPKTKTPSQSSRKGKAKDSKDGDATPRPKARGRPSAAASRQASREVTPADVVPKIKIKAHALTNGRKRERSEVEADKGSGVVLRLKVPPLEPDPPPPEEEEEEEEEDPVDPYGGVLEGEDADTSRTRIIPADKQLFEKTRKAAETRLGGPPEPMWDPQAMIASPGPSSRPSTPGPSRTSIGFPNQPPATPTPTKDLSGIATPTARSLRDRVLLHQTASLSGLPNGAATPTAPSSTPAGHPERINKIRFGIYDIDTWYQAPYPEEYAQVPDGRLWLCEFCLKYMKSGFVAGRHRMKCKQRHPPGDEIYREGNISVFEVDGRKNKIYCQNLCLLAKMFLDHKTLYYDVEPFLFYVMTEVDEMGARFVGYFSKEKRSPVNNVSCIMTLPVRQRKGWGYLLSKKEGRVGSPEKPLSGLGALSYKSYWKLSVFQYLRDAPPNVTLEDISAATSMTLEDIYVTLRDQDMIDVPEHMTPVTPVPQKRKRGRPPRNPTRQAEPESKSIEVPKRYKIVPDHYLIEDVLRRHEAKGYLKLRPDRLKYTPFLTTLEPPPVPQIAQHVTRKDESDSEEGTPAKTEADDETPAEPTPEEEAALVAAGQDKETLELVAALSGSPVRSLRKRSSTNPSPENPQKRLRASASPVRRRTVTPNPKPKSTRASSKSAESRARSTSRTPKAKTVSPKKRPTPKKEPPGDEGFEEPEEPEDEFEDGDDGDEEWGEEDAEGEDDEEYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V409</accession>
    <name>K1V409_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V409"/>
    <dbReference type="HOGENOM" id="CLU_517945_0_0_1"/>
    <dbReference type="InParanoid" id="K1V409"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="526" mass="56933" checksum="1737D847AF3E0592" modified="2012-11-28" version="1">MSCPPSPTLSATSAEFVHIPDDNPVNIPENLRAYIQTEIAKGIAEGLASARSELKSDLMAELRTYIDEEFEDASDASETSSTTTTSSSSSSETPDSSTSEELAELQDRLERLDTDLTRECEIRAELGVSLSDFQHTTKAQMLRLLTMERFNELREEVLREVRVTLAAGRETQRLYHARTRVDLLALIEAQRKHFSEEMARAGEKQLEAYRDEFGPNVTARLEELEHASSTATRRISRLRRTQRRLSAAAESMVRGTEQEEVWKAAWAKTIVREGDQEEGAWKWLDAKREEKASPIPGAWPVLPDTESPETTNETATKTEDESATEGAMKPAIEAVSKSMSEVKIESTGESKPADDETTKSAQSAPSSILSSAPKTKGTFNFTTPSTIDTTPAYPDNTSGTSPPAVSPVSSTADARDSSEAPTVAGSGASTGPSAPSNLRPGMSLYPANVVEFKDGVTFRIPLEAAGGRRSRGWRGSRGSRDGSAPTSSCGCRGCRKPKPASAVPPPSVNAVELKGDAERKEGEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4R0</accession>
    <name>K1V4R0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4R0"/>
    <dbReference type="STRING" id="1220162.K1V4R0"/>
    <dbReference type="eggNOG" id="ENOG502RX8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285315_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4R0"/>
    <dbReference type="OMA" id="SHCQPAY"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1086" mass="117489" checksum="2241A166B3798E97" modified="2012-11-28" version="1">MSSQFSRPGQPSPSPGLSAPSTPPRHPTQDTSPADINDGNASNVSTVDPNSAGDDYAVLPSETNTGSTPSNPANPTRRDSMEDLEFSIGPPGQTEEDDSNIGPQATAFMTPTPGQRRASEDQPPPVTVKDFARPSSPTPHFQEPTDSPRLRSDDAPKRAASTKRSPSIKGSVGGRRGSHGHSSRPHRPSILTNTPRTPWSTQTQAAAPSTPQPPILTLTPAVASDQPEFAELLTPAQLRKRRKQRVPPSQLGTGLGVLAGRPILAGPSRLGFATPDGDLYRGATDNPVAPTEPTAVDDDAITVASSASSDSSASGIGARATDLVHRVGEAIGMRRGSSSSGSDTSSSSSSSASTSGFSIGRFGRALTRTMSRATNDSAAEERPKRVYVPRRREFTLLLPPGEKLPQKPNEATVITTPMLPPILEAIRSVRATNGIAGALDVRPPLSSRKHHHHSDLAVRRGGSAPGRKRAQFVNPPIPRMPRVEALRGAGPVRPKSASDLLGLAAGPGRNHSSPDLASVRSSSGSSTDSTAPPLSPTPTLRPQPKPAWWLDVSCPTWKDLRDIGELLALHPLTLEDVLHQDPREKLDTFHKLGYYFIVIRALDEQYFKYTPGTSGPPGTELEITNPNHTGSREGDGGTKERRRRGWGFGRATGRAATKIGEKVEIVENDPGKEGLEGVGVGGINLYLVVFADGIVSHVTRVRDRVLQVQESVPSPDWIAHGLIDSIVDAFFPLMGYVDGAVDDMDSLTIDPTRDPRIQTVQPSQNIEAPNPSDDPYSQFGEEHAWIDMEKDPQKLDEKMASSTGVSLSEKTGLRQRRVSTSMFEAAKAASEKAAAAAKSVRKSAAVAVPKKTRLLDHTWTRPLLYLYLYMLPTTSAVEHVREEGGEDVFDRSTMLRSIANMRRLVTGLSRMLGGKHTVVAALLKRTRDSADDVEAYLSDVHDHILLLQTSLYHYEYILSHCQPAYLSYLQVSGTLSRGGTDKLILALSTVTIGILPMQFVLALFSMNVHVPHNGMSDPPDGIDEHREPDDTLAPFNWFIVIVFVITVIALGVLGIIRYWRWLARKKWTIRRGGQLPGEWDGFWGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4T9</accession>
    <name>K1V4T9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4T9"/>
    <dbReference type="HOGENOM" id="CLU_1541202_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4T9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851834" evidence="1">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="189" mass="20890" checksum="8F338016556C22CA" modified="2012-11-28" version="1">MLCLSVLTFVMAALVSAAPPPKKDKNQFTIRPIAQQDKCLDVEPASGESVGYALPCRKERGRAVASQTFEWETQAPDADPLDFTAELLRTSYQVNGAPGCLWTEAPEDTPYPGVVPSVAACPAKDSEEYDNFRWRKTDNQGLQIYRPRGLRPGLRMISLAREDNNQTNTVAALKSFSDTDDMKCVFIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5E3</accession>
    <name>K1V5E3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5E3"/>
    <dbReference type="STRING" id="1220162.K1V5E3"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5E3"/>
    <dbReference type="OMA" id="WKLKGVA"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="610" mass="66096" checksum="F94A338094C81DF1" modified="2012-11-28" version="1">MSSEKLSSDSKSANYAASVHAASVNDPVHEVLYTDSGVVIGEKGENGAGVTYQSASGAPVEARSPLGYSVGTWTALFLNVSMIVGTGIFSTRGDRHETGKIVSSETFLCAGQSYEGKVPSILQSTGSIGLSLVYWAIGFVLTLAGLSVYLELLSYFPSRSGSEVVYLEQAFPRPRFFFPVAFAVQTIILSFTSGNAIVLATWIFRLCGHTGSEWALKGTAIGAFAAISLVPILSTRFSLFAVNVFGTIKLLTLVFIAIAGFVVLGGKTSIQNPKQNFHNAFAGTRSDGYAQANALVSIIYSYQGFQNTFNVANEVRNPVPTLKKASNAAVIVVAILYTLVNIAYFAAIPKAELASSAQVTATLFFERLFGARTAQGLTILPVLSAIGNILAVIVGQARIIREIGRQGVLPWNRWWVNIRPFGTPIGPVITIWLVTTVMILAPPAGDAFNFVIALQNYPESAFFALMTVGLFVIRRKRAKLGLPRGEYRAWTASVLLFLASKIYLLIMPWVPPSEGINASSFHFFYATPSIVGLAIIAISGGYFWVWGQLLPRWRSYAIRRRVTTWPDGAVGHELVRVPLDELQEWDDKHDPAGRSIHSETTTVVDDPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5K3</accession>
    <name>K1V5K3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253781_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5K3"/>
    <dbReference type="OMA" id="WYSPWAW"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="858"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1340" mass="142534" checksum="0B652DA628C7C0AB" modified="2012-11-28" version="1">MRRPPPALRTPGLGPRKAKPAVTLVFAAGDAVPPNVPLGLRRAVSGASPSEEALSRQLDQDMAGERLGLRSRRSSAATLASLRTFSADAGNTVQEEEGECDDQQAGPSRPRENTDTLQVPSCAVSTSTPSVMSDVEPTKPEPPSTPPRKVNPKHSGAWLRWNSPTPTFPKRGEKGKGREVESLAEPDHNTDTAPGQRSDAPTPTRNVGTTSAHTGDTQPGTSASARGPSPSHAHEDADINDVSGLLGRNSLNSSTTTNPVSSLTSSTASKPAESTMLAAPAEVTEKEVEAPTQSDPQSDPPPSPQPEAQSQAQPEPPKGWLEYVFGPSRPRAPAPAAKTPSTSRASAPVSTPSRTSTPTVHPAPSTQAAIATKNKAESVVSTSSTSRPPATAHSSHGPVMNGNGNEPNAKRCKLDPEIASLAPSTTPTKAPPTVSSTSAAKLMARESPAAASLKATSIRNGRPGHVPSTTTQPTPNMPSEPSSKASSAAGSAPHTPVRRSMDSTREPDSPADDPDLTPKAEPMHVAEVQGWGAYFTSFVFSSTVSTPAKPQEQPERPKNTTGHSKDSDATIVEATDPAADQKPLPTEELPGQPDERTSTPPPAHLPAPPQPVAQGSTPSPGSKNKLASSTSSTAGWLNYLAFRASQKKITGSTVGSSEPRVSGETAREEVMDFENDPNFPTAESPTKAAAEKALVKKEQKEQPAATQRARDKNLTHKRSQNLSQAQSLALEARRQSSTSSTRSGVLANERPLAAANKPKSSLPPPPQPPAKQPSLLIPSFETTFDRPPRSFLPRTTAGGVATVTGVAWRALGAMSSYVYGEKEDANKDMRGRKAGRDVGADLPRRIGLGSGTPDDGWKNVRRVVVVGVHGWFPVKMLTSVIGEPTGTSVRFANMMGEAVKKFFREKGIDDSEIRLTLIPLEGEGTIENRVDKLYKAYLSNPAWINDLRRADAIFFAAHSQGCIVTTHLISRMIAQGHIRTPHNRDAVARCEWAFGPIAIVPSEDSKKGKQKLAHLTGAEGGRQKVAMLAMCGVHLGPFLHISTSSVIGPYLQWFENAAARELFEFQDTESPVSQAYQRALAMILENEVRILLLSSINDQVVPIYGASFSTATHPLLLRALFVDGASYLAEDFMTNLMCFAFMLRNAGIDDQGLVEHLSEATAGSLTGVGHSSPYDDLACYSLLVHYLLHAGPAASPLPPLKIEPFSAKDTKNDFELPWIMRALVDSPEINDLFPSEVRQLKESIADWKPNTKALKEIKKRLEPMAGRKRRVASGLSGLNTVNSSTSSLPGLVNEAGAETGKKQPSKPQSKLLSRATEQRQTIRSECAADAATLTVPPITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6C3</accession>
    <name>K1V6C3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_06095</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6C3"/>
    <dbReference type="FunCoup" id="K1V6C3">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V6C3"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011361_2_0_1"/>
    <dbReference type="InParanoid" id="K1V6C3"/>
    <dbReference type="OMA" id="HSCLDFF"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="202"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="636" mass="70531" checksum="66F4043699220DDF" modified="2012-11-28" version="1">MTTPTPVPAPSRNNPISLRIYKAISTNFDDAASREALEIASGFYAKRDKGKSKADSSPSVSNTYHDDDEDFVPRRRTLKGQSAAAARRNLKRDVEARMAGGSQRFLDAFGEVDKGELDQANSGTKFLLERADGLRSQRASAQLRTSLVQLFLARFTLSPTEEAALSSREVEVGPEVFAALEHVERIRDDCRALLGGDEGKMQAGLDIMAATGAAMEAGYAKVSRWCELQFRQMTRESQLDVSSSLKAGVRRLGSRPQMLKDALSVLASTRQAAILQAFLDALTRGGPNGLPRPIEIHAHDPTRYVGDMLAWVHQMTASEHEFLEQLFEVRTGRRMVGAERAAASNDAQRLVAEVLDRNLEGLGRPLKLRIEQTVKTQEGVVMTYKIVNLVQFYLVTMRKTIGADALLSRTLQELYDYADAAFFETLQAQGRSLLRFLHILREIIAVYDTSLVDAEERETDFAKLLDAAVDPAVEMCERMADLRKNTGNTGSTWDRDVFLVNCLEYLQHTLESYAFTAPRVRKLQASVQEHVDSMTFEHGAGQPSPRATAHSEGTLFCSRAILLLPHQPRPAHVAPPRAARQPRLAETIHGAALRHIADAYGEIADRVLDKNEGYEFPETLLRRGKEEVQVALGITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V748</accession>
    <name>K1V748_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V748"/>
    <dbReference type="HOGENOM" id="CLU_1595722_0_0_1"/>
    <dbReference type="InParanoid" id="K1V748"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="167" mass="17495" checksum="153BA4AF1EA152F9" modified="2012-11-28" version="1">MSAHSNANDVSNKSSNAANSLADGVSGAWNEIKDQVQLYVAWMPASSEGSMTSPKARTAFGVAADRPMPQTKVHPSSHGNLFDADTTGAGDEARGSFNQFADSLGDKIAGRDHPLPSGNDNTGTIEQGEKEREQGRNQWNRASAEHQANKSSSTATGTAPSATTGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9S3</accession>
    <name>K1V9S3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9S3"/>
    <dbReference type="FunCoup" id="K1V9S3">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9S3"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_1_2_1"/>
    <dbReference type="InParanoid" id="K1V9S3"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="165"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="340" mass="38295" checksum="F08D14501DDCF388" modified="2012-11-28" version="1">MAAPTTPANGDKPSAGNMTSADYYADSYAHFGIHEEMLKDQVRTLSYRNAIIQNKHLFKDKVVLDVGCGTGILSMFAATAGAKQVIGIDMSNILDTAQKIIDANGFTDKITLLKGKLEDVELPVKQVDIIISEWMGYFLLYESMLDTVLLARDKYLAPDGLLFPDEATIYLAAIEDQDYKEEKINFWDDVYGFDYSCIKEIALKEPLVDCVELKSVVTQPCAIKHIDIRTVKKEDLDFTVPFELKATRNDYIHAFLGWFDISFSCCHKPVQFSTGPHAKYTHWKQTVFYTPDTLTVSEGDVVKGTLKCSPNARNNRDLDIEIDYEVEGAEAVKNKMVYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAQ5</accession>
    <name>K1VAQ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mediator complex subunit Med25 PTOV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAQ5"/>
    <dbReference type="eggNOG" id="ENOG502QR8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283312_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAQ5"/>
    <dbReference type="OMA" id="ANMKHED"/>
    <dbReference type="OrthoDB" id="2574970at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021394">
        <property type="entry name" value="Med25_PTOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11232">
        <property type="entry name" value="Med25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit Med25 PTOV" evidence="2">
        <location>
            <begin position="580"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1100" mass="117193" checksum="7D208F5C47D24205" modified="2012-11-28" version="1">MDHQPEASSSTGAPPIVHTATLVFDSGLSRERFSDLIGPNGSVPKVVQRLTEKYGGEQAVRIGLVITAQDAPYHNPRALHSLIPAYRQDFRRPSSFITSLPSLLGRFTPQAALARPKPGSLLSDVWDIEDGAGLSITSSEPGPSDHFLSGIVGGIELLDHQAHLNFVPPPNALRQVSPDSALPMLSMMYRAQGGAEERQQHLLVFTEKASLQATESDARQPHAWARTDTSADYDDFNWDNIGEKCKEKDIACSAIIVGSPEASQTVSTPGRDGSQSVERLRKMCQASSSEPPSDPWFPLPPDSVAVLTGMTIVKPTSPPAGLATNGAPVPQKQGSQDPSTPQTPSEAQIKYQQAQKQALAYKMAVAAAQAGGGGGPALQALASLIQSGRLDPTVMAQLIANMKHEDPATRHKAMQQLSSLVQSRNLNNGNMNAATQALNTMNGNQGPSNGPSLQQQQFLAAMQARQQQQQQQQNAQAGNNQNNASQASTQPQPPQQQQQQPQQQQQQQQPSQQQPQMPGPRPPGDNKPTPQQQQQQLLQQQQQMLALQNLASQQNAGSSSGNVTNNPAGPGTAVPPRPNRVWQGSISWTMKGSDNKPQKWVIPVDCTLLSPQVNPNDLHVNTWPSTLEMSGMSGMNMAELQSYVKAHQAPCVLFTVNQAADAQARGKIQYLTMMLGAKNLCAFIRFGAPGCGILLISSNGSQQQPNPSGEKIYRLLGVVCLKVPFLPGNNMLNPMANQVQLGGQQNQQNPQAAQQAAAQAQAAVNGARPGQVPINGPPGQFSISPQFLQQAQLQAAQLQQQQQQGTPQTQARTPQNLSTPQPQQTTPQQQSTPRVPNPALGNALGNNALNANALQQFANQPNVNTIQQLQLRQLQAQAQAQAQGQGAQNLQNMARPALQFTPQQRAGIIKIMRDAGLNVSDSFDPASIPKEQLAAFINSARERGKAAQAQQAQAAHQAAASKLQGQQGNLPINGQGLGSNVNMGNLGGLNLGNVGNVGGNVGNLNLGSNVGVSGLQLGNMPFNMLPNTGNDGQQGQQGQQGQQGLQLGQFAGLQQFQQQQGQQQNQNNPQNSALGLFAQGQQGMQGGVNPQLPLGLFQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB17</accession>
    <name>K1VB17_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB17"/>
    <dbReference type="FunCoup" id="K1VB17">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VB17"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="K1VB17"/>
    <dbReference type="OMA" id="GLMQDWP"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="454"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="553" mass="59723" checksum="8514E2F42BAEB3D8" modified="2012-11-28" version="1">MPPNIIRPQLPPPFLPTLSAWEYVFPSGPGISPGAGPWPGQTTAFIDGLTGRSMTRAEVHDTALKLKGGLNARGVKRGDTAAIFGSNSIEWALAAWGCLAAGVVVTPCSSAFGTSELTYQLNDSGATVLFISPELLPVFEKCRSELKFSFPSDRVILLTPPDAPNQKYPSLWSSLGPLSEPEPFNGVDAHETAWLCYSSGTTGLPKGVQTTHHNLTTQFETTTLIRPLPKHGQDVILGFLPFSHMYGILAVVTTPVLAGVPAIILPKYDELAALKLIQKYKVTKFSAVPAVLLGLVHSPHVPRHDVSSLVEIRCGAAPMGPELAALFRARFPNCVISQGYGMTEASPAITLPTPEDDRAGRPGVGRLVPSYEARIVTESGEDAQPGQPGEIWVRGPNVMRGYHGKPDANAKSFAPGHWFKTGDVLYQDEEGGFHVVDRLKELIKYKGFQVPPAEMESLLLSHPDIVDSGVVGVYDAAQATELPRAYVVLESGKQVAPQEIAQWVANRVAQYKKLRGGVVVVEGIPRGATGKIMRNKLRERAKEEWEAEGRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBB6</accession>
    <name>K1VBB6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAC3/GANP domain protein associated with nuclear localization of protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000320">
        <property type="protein sequence ID" value="EKD01335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBB6"/>
    <dbReference type="FunCoup" id="K1VBB6">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBB6"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015513_0_1_1"/>
    <dbReference type="InParanoid" id="K1VBB6"/>
    <dbReference type="OMA" id="WPPQLKE"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="221"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="411" mass="46455" checksum="ADE0AADFC844A1DC" modified="2012-11-28" version="1">MSSSWPPQLKEWVQQCLAKATSANKTAVNNELKQAHKDGTVNTTDWSKVELKTDNPTTPSFPSAYTFDTTEQDEAKARRAARFQKEAEVFKNGGNEQSGPHYTPDADADLGSRIAGIGPLPSQVGRKKLKGKGGAGFGYAEPEPEVDPNVINWDKYTIKGTSTKLEKSYLRLTSEPSPADIRPLPVLKQTLQLLKQKWKQNHNYAYALDQFKSMRQDLTKDLGEYNQCQSMLRQLYELGLSGHPKEFLSYRIMYLLHTKNMSDMTSLLAALTPEEKEDPGVHHALQVHAALVTSNYVRFFRLFLEAPNMSGYIMDHFVERERAQALAIMSKAYMTLPLPYLTKTLAFEDDEETDQFLSAHNAAVYTYTRDPKDPWKPIALSERVWDCKKAHGACVHATQQYRVVDLKGQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBR5</accession>
    <name>K1VBR5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-binding cassette transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_04297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBR5"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="InParanoid" id="K1VBR5"/>
    <dbReference type="OMA" id="HCQALWH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="958"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="411"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="565"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="927"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1240"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD01455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1533" mass="168864" checksum="D95E2FC4476448DB" modified="2012-11-28" version="1">MPTGEQQSFLSRQAGYGATQSAPAAPERDRDDIDIDVPVHLTQFRDNIRQCKAALVLTLSAALGTGIWHLTRLPVPHKLGSSIGGWYPAAVWGCDLTALVFTHWPAGHDADQTPLPAPPASSLARQAAQHGHPSRCTKRGAPSTGLPSWLHVASLLASVLAAGLMRRGPLLCAEIAVSTFGLSGVEARQNADQNGNHANSKDDDLWDEKRKPEVIDYGNSSMIKFLALGYVAGKSITQTELQQKDLPLLEEWVRTSGDEYLRTLGPRGDHFKPYTTFILETLNTVIAYVQIAALRELIASFKHPSDDYSYSYLMCWGLFFGQVVEVLLSAYLWVRENYILHNPVRMTLSAIILRSTDAKAMEAQNMSEEDTKAGKGRAQVMNLLTIDTNTVASMATYVWGISNGLIRLCDKAWARARDARIGAIKEFLMGIKVIKLNAFEEYEIERIGKLRDIETKWQRWRYTLGTLFNIVADEMPNVAVLVTFVFYTKVLGNRLEPETAFITTTIFYRVREGLEVLPRIVDILLSTKIALDRLKGYLNQDEVVLNPADVSEGQIVLNDATMTWPRVEDVTGDMQTTDSSERLFEIKDVSLTLPRGKMTLVCGPLGSGKTLLLRSLLGETKLVSGRIVTPRSAPDMTPLDASMVKFRWTNELWLDNSVAYAPQMPYIRHGTVKDNITFGQPFWQDRYNEVLRQCSLESDIELLVDGDRTEVGENGVNLSGGQKARINLARCVYSRARTIYLDDILSAVDAHTARFIVDECFKGSLLKGRTVVLVSHHVDLCLPASEYVVALSNGKIEQSCPSKRAHVGSLIALASPKHEAKEEEPPARPAGHGRSDSLVAETQDILHTLEGESRRAPGAPPRSPSGRSADLQLYEDTRLVDDEAFEEAEVREARHLYKAEDQKSGHVAGSHYWMMIKAAGGFGYWTIFAICYILAKGSSMVVSYVLEIWTDDPDQSHLDYYLSLYIGVNVIYVLFGSIRWVWLYGVGNVGWYSAGTKKIHRKLFKTIAQAPLSFFESVPSGRLLNVFAQDMRRLDAQSADDFGRTVQQVITVVGAAGIVVFKVPSLFFVMVLFGIPLFMIANGLGKLRSTLRRLAAVADSPLISLYHDSIDGVVMLRAFGLPNLMAHTMVGLINKSRTAETWNWIVYNWVRGVVLSGSSVFITATAIVLVGKDISAAQAGFILSFAAQISTNLFGLLEQLISMEQTFVSAERVNHYLEEIPQEPEKGLEPPPSWPVNGKIEIKDMSLRYAPDLPDVLHGINLVIEPGQRVGIVGATGSGKSTLALSLFRANEPNEGLIKIDGLDISTLSLQALRSRLNMVVQEGSLPSGTLRNALDVSGQRSAEEILSALRRVHLIPKTQATAIGSATSTPVSPFANLDTGAKNLKAGDPFANLDTFVAVEGSNFSHGQRQLLCLARALLKPSKVLIMDEATSSCDYETDALITETLKEDFAGITMLVIAHRLRTIIEFDKIVVLDQGRIVEEGAPEDLLDMPDKKGRFKALCAAQGREEFDRLVAMARGRKAPSPGTDSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC26</accession>
    <name>K1VC26_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC26"/>
    <dbReference type="STRING" id="1220162.K1VC26"/>
    <dbReference type="eggNOG" id="ENOG502QWA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_5_0_1"/>
    <dbReference type="InParanoid" id="K1VC26"/>
    <dbReference type="OMA" id="HPRDDHR"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="58"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="524" mass="57305" checksum="FCF926BF73997C50" modified="2012-11-28" version="1">MGVKILKNGKIFTSTDNKQCEALVVDGERITFVGSSADAAKHAGALGGALTKVDCLGKNIQQVQEAIKKRRAEQPNAKMVLGCQFQYDALGCMPHKKYLDEVAPDFPVIIDSSSLHTSWVNSAALKAMGIDNSTPNPQGGEWVRDENGELTGYVKETPVMETVWPYLVRETSDAERVTMLKSVFDAYLATGVTGAVDLATVPEDLTALEGAVRDYGGRLPIRIACHWLMRPGGTREQRLEQVRTAAAHRERLAHLAPWLTIAGIKIVSDGVIDSCTAYLSEPYPNGATPGPIWPSDELAEVVQLADELGMQVACHAIGDAAVAQALDVFEAAAEKNGPKERRHRIEHLELVSEDSIKRLAKAGVIASMQPVHADPVKVVNWCDVLNHDHRCDRMFPWREFEDENANVAFGSDAPTAPYHPLPNMYTATTHKSAIDPNRPDPTTEREKNLARLCVSLETSIKYYTAGAAFAMRTDDQAGTLAPGKSADFCVLDIDPWVQGLDSLRKAQRGVAETWVAGERVWKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE04</accession>
    <name>K1VE04_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE04"/>
    <dbReference type="HOGENOM" id="CLU_1020103_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE04"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853721" evidence="2">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="318" mass="32638" checksum="633B534B055CDB7D" modified="2012-11-28" version="1">MFGSGLLALASAQASLASSSVSAQANASEAAPPMVGGTLATPTWAPPNVPCDPKQVTWFYQATFTYAHKCSEACNKWYGLLYKYGTYTGPLSAGQREPDGKYVIEPEVSCPQVDWLVDCMTCTLVNATKPAPNSTIELGARNVVTACRQGGYTIPASMYRNINPHVDPLGSVAINDLCHTKIVGCFGDVDCSNLTDPTGKWFYNSTTGAYNNRSPGGDSVDVSAKNINPVPLSEGQGRTSGAPGATGSSTNNAASGGASSTESHPSSSISGTLSEPEATSGASAAAASQVQSADSSATVGSVSLVLGLGMMTVLTLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE37</accession>
    <name>K1VE37_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE37"/>
    <dbReference type="STRING" id="1220162.K1VE37"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448479_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE37"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="63426" checksum="10F236D0B256EADA" modified="2012-11-28" version="1">MADDDDWVKELKEHQERQAKIDAQFEADVAAIKRGELTFETLAAQAFAGWDSASDSTASPLKSAFGAGSVFDSAAKEKRGLDEPAETGRSNLTGFGAFSGAASPFAKKEGTGLGAFGSMPSAKPGLPAWGGFGSTGLDLKAAIKFIHGNATAPPSDKTADGNSFNKPAGGSLFGQASTSTPAASTGTGFGGFGQQAQQSTTQPAASSGGLFGGFGQQNNAATTNTASTGGLFGQKPAAPATGGLFGQQQQSTTQPATGGLFGQQNQQQPAATGGLFGQQSQAKPAGGLFGQQSTTTPATGGLFGQQTQQQPATGGLFGQQSQAAKPAGGLFGQQSTTTPATGGLFGQPQQQQQQQQGGLFASQQPQQNSLFNKPAGGLLGNSTSFQQPQQQSGISKTAKFSDLPEGAQKVIEQMDAFFKDQRHVGQTIDAEPIGRAIWQTSSDIKVAHDEAAAIAQGLDALKHSLERLAAKVQAQAADLQKLLETWEAAKPADARHPGVRPVAHRDFPQEYFARVAAEEAERVTRYKRNIQLLSRAVVSLASDVESMTPQVVVQTIQNNQSAILALAAQLEGLEMRMNTLRANFTEHTNSMRDPFQVAREEKGLPLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEQ1</accession>
    <name>K1VEQ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEQ1"/>
    <dbReference type="STRING" id="1220162.K1VEQ1"/>
    <dbReference type="eggNOG" id="KOG2844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_8_0_1"/>
    <dbReference type="InParanoid" id="K1VEQ1"/>
    <dbReference type="OMA" id="VAHPYTF"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF193">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="416" mass="44773" checksum="F97CFF90C7FAFFF6" modified="2012-11-28" version="1">MSDQQYDVIVVGAGIAGSLLSRNLSPHVRTLLLDRSLSFPGSTGHAPGFVGELNTIPTLTQLARRSIALYRSIPGGFNSVGGLEVLQGPNWPGKTAADTAQTLMDREKLAREQGVEAEVLLPKEAARQCPALVRPDNGGGIKFPNDGTANARRISLWGREQAQSEGAKIVEAEVSSIDGSGDDWTVKTSNGTFKAKRVVLATGIWASQLAPETQVTALPVAHPYAYTKVRAEREQTGPFVRFPGPHVYARDHGDRDGVGSYAHDPIHVLHTSKLASAYGAWDPNFNRVLNRALSILPKDTADAFDPIKPLPESYHGDVPKGAYAFNGLFTVTPDGLPLFGQSKTGLWLAVGAWVTNAGGACDVLAKEIRASLGQKVEQESELAKEMDPRRFEGRDPEEVSKQALATYNDIYNKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF65</accession>
    <name>K1VF65_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rrp15p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF65"/>
    <dbReference type="STRING" id="1220162.K1VF65"/>
    <dbReference type="eggNOG" id="ENOG502S6W0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088030_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF65"/>
    <dbReference type="OMA" id="DFFNMIR"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28177" checksum="247AAF4C48E43CFC" modified="2012-11-28" version="1">MSSKTAPKSILKKPAVAGPSKLTGSKGKAKATVAVKTAKVKAPSPEPESSDDNDFPDDDEYELDTEDEIELAQAGSEKKQPKRKRPTTASEFGSTLTSLLAEPTSKKAKKVKKEDDKKPKSQPILALSAKPLPPSQAAERLERRAARVLKAERMERLDRARVRDVVEGWVPAPGAEMGSQEFERALRKTAQRGVIKLFNAILVASKNAEAAAKTLSDKAGLKPEAPKSRKEKDNILGRGGKDDVLTKESFLDLVRRGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFD7</accession>
    <name>K1VFD7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFD7"/>
    <dbReference type="STRING" id="1220162.K1VFD7"/>
    <dbReference type="eggNOG" id="ENOG502S09X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045028_1_0_1"/>
    <dbReference type="InParanoid" id="K1VFD7"/>
    <dbReference type="OMA" id="DVPMMLK"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="351" mass="38424" checksum="216B2328C7FF670A" modified="2012-11-28" version="1">MFIYNVHAPNKTFALKAKETEDCDALLSRILAKAKLNDDDENAVRSNRDGAGVVYEFDGDRWALEDNDDLSIVTERFKTEDRQGKAMPSVTLHIVQPNANKSNNGYLAPPPPAYGSSSQQQQYAGKSQRKKSNSRLNANGSQAGGRPSSRAGSRAGSRASVAPSTHSTIVIRSGTDPLTASTSLCIPNRDKNRARSVRSMRSTTSRKSKWGDDDAEPLGDVKRRQFEDVGIICGVRMLLKQGYRGVYVSRSFAVRHGLISRKERPGFGGYGGLVMLGNVPITVGEKTALHPVMLSEEQHFDVVLGRSWIEKMNIKVDPLDPTALTYMDTGETIPCDLVVLRDAKGNIITIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFE5</accession>
    <name>K1VFE5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFE5"/>
    <dbReference type="HOGENOM" id="CLU_1476158_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFE5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="183" mass="19943" checksum="AF2615C752AD6596" modified="2012-11-28" version="1">MLSKIKSMATPTKSHRTHKRRPAISAPIPIPTCLQPQPVTQEDAWATLRAAYEAKAARSPASSISSAPSSCYSGDSHDSRHSRESSGSSLEPSTSCRRPHRHRPSVRRVQTAEKEGKDADIEAIPTPTAQHARSTSATSWQVLHELIDDSCEDDAASIVSHTSIVTDYEEGQYSIKRAEVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFK0</accession>
    <name>K1VFK0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFK0"/>
    <dbReference type="eggNOG" id="ENOG502TM1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1090663_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFK0"/>
    <dbReference type="OMA" id="RQPAECT"/>
    <dbReference type="OrthoDB" id="10674855at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="255" mass="27061" checksum="674E463DFDDDD2A5" modified="2012-11-28" version="1">MAITLAKDRSSTTLSLPFGSATILADALPPVLDPALLSGPATDKLCAARVRLLNSLPQVSIAWSLWCVKCGTLRDGYRPPRGNKRKAAPVDAADELEAELHAALAQMDADDRRRRSAQCSTCGNQFRRPKPTPSFYASARSVARTRRASRLAAEVKPDEPPTPKEPTKTEQALAVPEGQRGKAALTRTPSLAHIPTSDPGFPTYPPPSASSGSSPAPSSPPPAKKRKTKKSGLAKLLAQNKAREAEKSSGNWGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFX5</accession>
    <name>K1VFX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260694_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFX5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1311" mass="144196" checksum="A9A061C1E014CE62" modified="2012-11-28" version="1">MASQPKPADTLLSAPLIRILAASSALPNMIWDGQNHSNDTYLSIVFNSRKARPLHLDSNKLQHFPTATFRFLPAQESKLQPPYPSTMATNGQSNDNCDGTKGSDDASVPATPHTVHNTTSRPARQRSIALMDETGSLSPEQPATSLCSNALYCVEVPVRETSNVRSFSSSNASQDSNTPSFPSTSVDRYTRVPPPVGWTRRSARDARTSSEKSPPHHCSTASSKTKSEPPTLTLTKATASKLPTISDPAPVSFDIATSGLYTRVSSSVTFENDHTRRTSSEPKSQRLAEREQQETALIKSSSPSLTAREAEGACPNPSELEHITTSQELTSASRPTSKRLRFYATDSESEFDVVPPKLPKTETPSEEVESGSADVEEWLETESSECTHDNDSTIYDNECVLLQRDINAVIEKAVESIGNLKPLHQRLDDCRKADDDLDQRLGRPKLVNRARVEDLRSSGNVEVDYSNLSAERLRCKVLRLANGVDAFGWSSDLIVDNSSPIPKPIQRVMNFVDRCRALHPSPDKHHQLGPDGPARHDPDNVTRTTFIDNMAKFGALRLSRDVVDLLLYIRAGDEDYDVSRPAAFLNNLADLNAASVFRKAVPQQRYQAYFQKHNDVLAFLDGRLPDYEWQTPLPMPNIVRQLASYPTPKPELVAQLAGTLLESSTRERLREIEANVRLWRPDAPAPIYNKDGACTLYFPGTTSTRLLARYVCAVFERVVLQCDRVWSINAKEAEAPALSPLKVYMHLFESLVEQAYVRIWSEDGTPELLGTADPLSGIPIDHSGTPGSPSKATYVAHEHHGLWISAFADDDGGDKYGNHCQESWAVNLTRGSWRFPTIAAHLRSRQRPLQVLANKLAAVGVIEPIRLRPFVPSAKMTALWTHNKVETVEAVARSSRLVDQVQAAFDAVQAATTADAARRSAAQSEVDQEAGHRAARLPSQLCTKCRTRVTSAGLCAACQQGTRRLQTYQRQLDKLHAASSTLQTLPALSPSSPIKRASRDKAIARLPPSGPDIVNAGYGIGLQPPPAVTFFAYTCSRYGREREKGWTGDAAQPVCKTCADAERRSSSAYMESHTCYECGTGSSSSWRKGNLPGSMLCSTCSDDKSPGLCIYPECPEVLDRWRWWPERPETGKVCGRHTMSLLRNEDDKSRLTGALDVVLEKAPKDCGPLDLKLRLAQHVSKYNIETAASSAKRSYTKAQPDPEVDSRLVRSAYPFDPACLYPLCPQEGVKGFPGLTQVGQLCQRHISTLARKARAQEKMELSRCLVRVCQRPSDCSLKEALAAAVKEEGIQLSATGPPQRPRATTATTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGQ9</accession>
    <name>K1VGQ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGQ9"/>
    <dbReference type="HOGENOM" id="CLU_1385058_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGQ9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="197" mass="21905" checksum="60142B4E0CB2EAF5" modified="2012-11-28" version="1">MPGNTSLRLTSSDTQASSSKHHRMSTKKPYAAPELPVEVENQTPPQAAVATQSNDIDMADSDEIDEYPLRFYSDEEDTDPEDLDYDPESRPTSPMSLTESERGDFAGVLKDLHEYDTDPIVPPPPEQIQGALALYTEKELEVLRNAYEMVYGRPARWFKEQSEEPMEESAAGDSDDADESAVLVDKAEASGEEWVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGX2</accession>
    <name>K1VGX2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome regulatory subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGX2"/>
    <dbReference type="FunCoup" id="K1VGX2">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGX2"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="InParanoid" id="K1VGX2"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="17"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="348" mass="38519" checksum="137B6BB15B884EEC" modified="2012-11-28" version="1">MPGLTTAQVNELSATNVVIHPLVLLSVVDHAARVPLPNKKRVLGVLLGQDDGNTINVANSFAVPFEEDDKDPKTFFLDLDYVEEMWRMFRKVNAKERPIGFYHTGPRLRSSDLEITELFKRFCPRPVMVIVDVRAHGGRGDTGIPTDAYFAVEEIRDDGTATQRTFTHVPTSIEAEEAEEIGVEHLLRDISSSSAAASSSLLTTQSLSNRVSAQLDSLRGLHARLKEISEYLNDVRKGKMPVNHQIIYQVQEIVGLLPQLGGDVDLGKAFRVQVNDQNVMVYLGLLIRTVQALHDLIDNRIANAQQEIDDSKSAEEKKTEAAAEAAGVKAEDVKRAKQENADDKDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH76</accession>
    <name>K1VH76_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH76"/>
    <dbReference type="FunCoup" id="K1VH76">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH76"/>
    <dbReference type="eggNOG" id="KOG2478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021991_3_0_1"/>
    <dbReference type="InParanoid" id="K1VH76"/>
    <dbReference type="OMA" id="LVCRIKY"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48079" checksum="D8F6BBA469E3C693" modified="2012-11-28" version="1">MSHKTKSDLLVRVRFENPLPPPPFPAKLFKVSTEIGRLGEPSYLDQLASSAPIPMLADAEMGMPLDLNVYPGVWDGDDSALNPVPDADRVQDATDALLLTPLNVTSNAPAKADVSWMRNSSYIQRRNGNVRRAAQERQRQEAVDHSEAAQILAIDKTFADVQVPAKEMKHPDPKRRHLKVVEEYDILPDAEAWSNSYILVKFPERPSAVTALNPTATASTARLESAVLRPIVEDDQQIIEYYLPPEEGVDRLAHVYATPLDGDGVERLNQTAEEGGDVDAVFPNVPYDRIRTYEVVMQAVPAKEVLLTFQEEEAEDEDDDMFGGEDEDDEPKRKRRKGVYYNPISFRTQLRKTRVAKRGHVETRGDNWDKIRIGFRQPDEDEVDERRAKDRQVDEPDWVEEKLGELRGGDPGAEQMGEAIREDIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI91</accession>
    <name>K1VI91_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI91"/>
    <dbReference type="FunCoup" id="K1VI91">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VI91"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="InParanoid" id="K1VI91"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="8">
        <location>
            <begin position="304"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="562" mass="62688" checksum="1F3CE0B725BB57DF" modified="2012-11-28" version="1">MSGSLTHVLFEGASGYCLYEVNLQEEIAARSKQLQDSINDYNTFNRMVSLASFLPFTSAAQALENANDVSEGILNPHLKSLLTMIIPSEGAKGNKKQSPVVLGVSERGLGGAIQGELGIPCDTSERALELIRGVRLHQDKFLAKEGLEKGDVTTAQLGLGHSYSRGKVKFNVNRSDNMIIQAISLSDQMDKDLNTFSMRCREWYGWHFPELYKLVPDAHQYAKLAVLIGDRATLTEDSIPEMQEILDDDETRARNVLDAARASMGSDISEVDLMNISTFAERVVQLAEYRQSLRRYLVEKMSIVAPNLSALIGETIAARLISHAGSLTNLAKYPASTVQILGAEKALFRALKTKGNTPKYGLIYHSSFIGRAGPKHKGRISRFLANKCSIACRIDCFSDVPTSKFGEALRNQVEERLNFFETGAPVSKNSDAISKALKAIAEDLDDEDDDEDEEIDDVELSEAVKQVTKDQEEAAKNRGPMDPELSKIAAGATSTPSKKEKKDKKDKKEKSKDKESKKEKRKREDSDDEDEEKRRKKEKKEKKEKKEKSKEKKEKKEKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIU5</accession>
    <name>K1VIU5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIU5"/>
    <dbReference type="STRING" id="1220162.K1VIU5"/>
    <dbReference type="eggNOG" id="ENOG502QY9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026175_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIU5"/>
    <dbReference type="OMA" id="PENPWID"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="560" mass="62619" checksum="FAD2146A6906CC39" modified="2012-11-28" version="1">MTGFGFSHQPLVNMFGSGITSFFRKIEVYGSENVPEEGPIIFACTHTNMAIDPAVLSYTVPHGYSLHYWVKDSLFRNPVMRAVMQNAGNIPMAAGECIGLFPEGTSHTNPRLIPLKDGLAWSALEYLIYLKGGDGQEPHKGKPVTIVPVGIAYCDKSKYRSRLVITYCPPITTDRYEKEFLSGGDAAKKAAVKRLTRDIELELYKTTVNGPDWETNYAADMARELLWKYDRDLALADYVDVQQTLVDLLSTNDPRIEKLKQMLYTYHQLLVASRLSNGALTDLPLQRNLDPNKVVPLPGRLRTLAILIKDTFISLIQFPLFVVPFLFNIPLYIIGMLGANMAENELETQAQMKVFLGIFISFLLYPIYFFIFLWMFRTVPLGGLFAAGVVWLLSKYHAALIDRNYAGLKKLVAAWRVLIGVWLGSRVEMNLNSFVDRAASYAPNPPQVAGLPAGKEAEKYVRPEKLPSRVLVRHVLRQRVQAARALTDTLLELEAADANVDASFWLAERYGGDVLPLSKAEMELPAYERPWPRGRRGAREVVAFLRGRGARLGGTNAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ54</accession>
    <name>K1VJ54_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ54"/>
    <dbReference type="STRING" id="1220162.K1VJ54"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654142_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ54"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="294"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46806" checksum="D9E743566CDA220E" modified="2012-11-28" version="1">MYEYKDGGPNKPESASTVIDLKFASVREGRGTDRRFVFEIVTPSHGRRLYQALSEADMKTWIYALCNAIEACINGTSTLRSLNDVKKLAPPDFDDDDTLPVRKGSGQSDRDRRLPIPPAVKQNTSRHSLPAPPRPAPPRGESSTPRGGQHRQSLKNRIKSSAELAGDKLGSKSGGKANRNSMDLQQRPAFMYANSFNHREEYYDMESDIERRVYEMAGLQRDARDAREQAPSSSGHSQVQHSQTSHSQQGQPQPQYPDTNLASLRALSPVLGSPGLPPGMEEQTVDVEPVKLDKALLRQIADTGANARCADCGKRTKSSRWATQSLRDMPMVMFLCIRCCGLHRGLGTHISKPRSVDLDNWAPEAIQLAQDWGNARGNAFWERNKPIDLVPSDEDIQDYIQAKYVEARWVAEVDRELLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJA9</accession>
    <name>K1VJA9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJA9"/>
    <dbReference type="STRING" id="1220162.K1VJA9"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894834_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJA9"/>
    <dbReference type="OMA" id="DHYTETI"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="115"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="35013" checksum="9DB0D0E3B7E03883" modified="2012-11-28" version="1">MPMSATLEKLLTPPALPVKGSQLSEEDKAAIAKFAAHFNAEDYTAPDGEDKTTRSPLILREYMFFTQGRINGYYQVHGTVEKTIEAIEKTIAWRRDRNMYDIDAFAKEVEDECRNGFAHFTGFDPEGRPIIYFFPNKDITPGAERRPLPNAFMMDRAGDFCVGDVGQVVIIQNFGGKRQGDLPSIGAATEQLSNLETHAPEVLYKLHFQQIGWMLRGFFALLNPVMPARTAAKILKQDTAQSIKDGYFTGDELIKEIGGNVDWSYKHDEYFWPMVEASKKIRADQEKRFEALGKPAMGVDERLFRVAPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJI5</accession>
    <name>K1VJI5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_01321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJI5"/>
    <dbReference type="FunCoup" id="K1VJI5">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJI5"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="InParanoid" id="K1VJI5"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="722"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="528"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="641"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD04290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="813" mass="88964" checksum="B6FEF2F79C5B1DE9" modified="2012-11-28" version="1">MDGDLIALVNKLQDTFNAIGGDAVDLPQIVVVGSQSSGKSSVLETIVGRDFLPRGSGIVTRRPLVLQLIHTNGLSGKNQSSNARPEPSRQQSNHLDENGYLPDLSAGQTGRKNDRSMGGDSGIDYAEFLHINRRFTDFDEVRREIEAETFRVAGQNKVSYLSLTEANAQGVSKLPINLKIYGSGLLNLTLVDLPGLTKVPVGDQPTDIERQIKNLLARTVDPRGLRTLGVLSKLDLMDAGTNALDVLTGRTYPLKLGFIGVVNRSQQDINLDLPLEDARRKEEEFFQNHPVYRNISHRCGTKFLAKTLNTVLMNHIREKLPDMKARLNTLMGQTQQELNSFGDATFLGEQNRGGLVLKLMTEFARDFVSSIEGTSIDVSTKELCGGARIYYIFNDVFGHALTSINPTHNLTLSDVRTAIRNSTGPRPSMFVPEVAFDLLVKPQIKLLEPPSLRCVELVYEELMKICHNCTSPELQRFPKLHAQLIEVVSELLRERLGPTSEYVSSLIQIQAAYINTNHPDFQAGSAAIAQQGAHAQLQPQKAPSLDGSASDDDTSSESSASVVNGTSPHHAPHSSTTSVPDARAPAASKILESTKKHGRGFSSSGAPSPVPAMPHMGASPHNAKESFLNYFFGGPNGMPVDSSSAPGSSHGHHVRPRVVERSNPSHHGSSAHEFLPDLNSGRRTASSGLDPGSATAYDMKSLGKHLDGDDHMDLSPREQMETNLILSLIASYFNIVRQTIEDLIPKAIMHLLVNFSRDAIQQRLVTQLYKPDLFEQLLHEDEALVSERGRVKALLDAYKEAFRVLSEVSLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJS7</accession>
    <name>K1VJS7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJS7"/>
    <dbReference type="FunCoup" id="K1VJS7">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJS7"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="InParanoid" id="K1VJS7"/>
    <dbReference type="OMA" id="TSQEVCN"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="717" mass="80048" checksum="38D1EA1EE3D584A5" modified="2012-11-28" version="1">MHMITVATCALDQWALDFEGNCKRILESIKIAKAKGATLRVGPELEISGYGCQDHFLEGDIILHSWEMLARILKDPEARGIVCDIGMPITHKNSTYNCRVIIHDGKIVLIRPKMWMANDGNYRELRHFTPWAKHRETEVHYLPSIISEITGQETVPFGDAVVPTADTCLGVELCEELFTPASPHIAMGLDGVEIFTNSSGSHHELRKLNRRVELIKEATMKLGGIYLYANQQGCDGDRLYYDGCAMIAVNGKIVARSSQFSLNDVEVVTATIDLETVRAHRKASSRRMQAAQQEAYERVPGLGGVRLSSKGMMLGWKETRPTDPDMVYHKPEEEIALGPACWLWDYLRRSRVQGYFLPLSGGIDSCATATIVHSMCRLVATAAREGNEQVIADARRMTGEPADSTYSPTDPKEFANRIFHTCYMGTENSSNETRTRARQLAEAIGAYHVDLNMDTAVSAVLGIFRMITGRTPQYAVHGGSGAENLALQNIQARLRMVVGYMFAQLLPWARGKVGGLLVLGSANVDESLRGYLTKYDCSSADVNPIGGVSKTDLKRFIAWAEGEFEMPILREFLDAVPSAELIPIQEGKGVQSDEVEMGMTYDELSAFGRLRKVDKCGPFSMFGKLVQEWGASLSPAEIAQKVKHFWFTHAINRHKMTTLTPSVHMESYSPDDNRFDLRPFLYPSRFEHQFKRIDDEAKRLQGLIDEGKIQPKPDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK34</accession>
    <name>K1VK34_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK34"/>
    <dbReference type="FunCoup" id="K1VK34">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VK34"/>
    <dbReference type="eggNOG" id="KOG3407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091076_1_1_1"/>
    <dbReference type="InParanoid" id="K1VK34"/>
    <dbReference type="OMA" id="PEDDAQM"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="132" mass="14900" checksum="4CC5F298E2453695" modified="2012-11-28" version="1">MDTTLAATNALRNYDPETRTLRLRQPGESGEDTVEKAVDGLAEEIVAEDEARRAEELDLFNIQPQRVNADLKRDMSRRMGKLERRTNEAIATIFRQRLQAQRKGDDGPDLLAGISAAQRENDDATREDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKF8</accession>
    <name>K1VKF8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKF8"/>
    <dbReference type="FunCoup" id="K1VKF8">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKF8"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="K1VKF8"/>
    <dbReference type="OMA" id="EADRRIW"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="459"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="561" mass="61514" checksum="F7CCEB8E4B86CB77" modified="2012-11-28" version="1">MTKTIYVSDHAIQPPLPETSLFTYLTGVGGPSPLPKFSPDLPAFIDGATDRILTRGDLINNALKLAGSLNALGLGKGSTACIWGFNSLPWAQTVYGCLAAGVTLSPANYAYEPHELAHQLNNSGAEIIFIDADLLPKFDAARKDLKREWPDSRIVLLEQSPANGGITSQRFKTVADLVKEGKPAQPAKFDGAEAHSNDSWRCYSSGTTGLPKGVQTSHWNMTSQLQCANIAFTNMAEGKDVVLCFLPFSHIYAVTLALCQPFSQGRPVVVLPRFEEIQVLKTIQKVTMVHLVPPLFLVLLQSKNVPNYDLSSIKKAMSGAAPLSSEICDAFLKLIPGVRILQGYGMTETSPNICTMNEHESVGRDGWVGRLIPHTEARLVDPETGMDSERGQPGELWVRSPSVMRGYHLNPKATAETIVEDGWLRTGDILVRDEQGWYKVVDRLKELIKYKGLQVAPAELEGLLLTNPGVKDVGVVGVWDAKQATEMPRAYVVSGVPPNELHRFVDDRVAQHKRLRGGIVFLEAIPKSPSGKILRKNLREMAKQDKEKVHYRAGQGARARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKX0</accession>
    <name>K1VKX0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKX0"/>
    <dbReference type="eggNOG" id="KOG1699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008003_0_1_1"/>
    <dbReference type="InParanoid" id="K1VKX0"/>
    <dbReference type="OMA" id="WSAREWA"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="10">
        <location>
            <begin position="336"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="894" mass="100239" checksum="5B2E3A3C89BD4D71" modified="2012-11-28" version="1">MPPQSGQARQSASQARLNPIWYSYACITVLAAVILGNLMRWSFLDYPDPYYCGALLTIGRWLDPGTYKVWQPEVFIGDSNVRQLYFAAVRAIDGGKNYTPKWEKDGDKHTNRGAVVKSKDGHRLNLDFWWDPYLNSTETIAFLKSTPKEPLSMLVMGSGLWYLRNPSSGGLAAWTMAIHSTFDLLREHQGQPDAPLQTPWDTMDQSLQFRMPGLLPSSAPARSKDKPNAENNFALADTVVFLPVPDPVDEKLSPERAATILHSDVEAMNADLSARLQHENPPPVVLPTVLNDLIVDSESDDGLHFSDKIMNKQAEILLSWRCADALRQDGLGQPSTCCRRYSYVRPLQGLLLVFLAVWSPLVAYFGHKLPAHSPIQRFVPGTKAALAVSTFGLSVTYLWFTDRTTMFLKENKDWDPKVFTILSVVSLVAGLATVRNRGKDLGFLNRDLTDEWKGWMQTVAILIYHFVGASKISGIYNPIRVLVAAYLFMTGYGHFFFYYKKADFGLQRVATVLVRLNLLSVVLPYTMNTNYVFYYFAPLVSWWYLIIYGVMALGSQYNDRAAFLLPKLVLSAVAIAAFMHYSFLMEYLFAFLNTVFKIQWTAREWTFRVTLDLYIVWGGMLTAYAYIKAKEHRLTEQPYFNQLRGGACVASVAALVWYFWYELHLESKFVYNKYHAYVSIVPILGYVVLRNASSRLRQHSSLLFCWVGQISLETFILQFHGWLAADTKAILLVLPPEYRPVNLAISTVCFIHLSWLVSGATGEITTWIIGKGKGKERLPAPATTAQPAQTTDEIPLLDRNQGDKDSESAPSGSGSGSGSGEPALETPASPNTTLDNSGYFRDNGAAVTGYDAPVRWSQHTVLSVVSNIRSLAQAHLSVKLGLVLLGLWVANWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL43</accession>
    <name>K1VL43_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL43"/>
    <dbReference type="HOGENOM" id="CLU_1533653_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL43"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="175" mass="19412" checksum="6B21C987B0106535" modified="2012-11-28" version="1">MSWPLTVREIVLDAQAQPLVDDVAGVHVQPVDHTPWWMCPLWTKGFNATIVSPASLEKKKKYRFSHPICKTEYGKVIHKDQSAIPRWPLKPSLPCLTASLRNHDTIITFYEPCGKIYACDSCAIHSVRADKCSLSGKHLTVKSAIPAAWDTMLTYITNGTPCHGVLNVDDPCGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLA6</accession>
    <name>K1VLA6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000180">
        <property type="protein sequence ID" value="EKD04975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLA6"/>
    <dbReference type="HOGENOM" id="CLU_1235806_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLA6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="224" mass="23886" checksum="E23F12873E2F99D5" modified="2012-11-28" version="1">MTSVDNASNPRSSPRAGTPVPGAPVEPQPGAGAGTGANTEAGTSGQVEQTTPGSPVGAGSEPNPASGTPRSPVEAGGSAAETQVSAIGEHAIIPCSECQTTPQDGQVRVCIRATQAACTFCKANRRRCTIDGRVPRKNNTRSKAAPVRTGPSVSRVTLTRWMRDLNEARRTLERTTERAQRYAREPWTAENQLRVAVALESARDDTEETLDRLHKEMVRFRDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLK5</accession>
    <name>K1VLK5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLK5"/>
    <dbReference type="STRING" id="1220162.K1VLK5"/>
    <dbReference type="eggNOG" id="ENOG502S1GD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010438_1_0_1"/>
    <dbReference type="InParanoid" id="K1VLK5"/>
    <dbReference type="OMA" id="GHATIMN"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="91513" checksum="DC25EF9A088D67F3" modified="2012-11-28" version="1">MDPDQLTSRGYGRYAEPSKYERGKIPGYDTFGHATIMNSTKGGQIARARYDELSEPPIPRPSSLFPSAGPTGKRGSRACVSWEGWFGNAEGRVISLENSVKELANGQSQIQQTILATLPHTGLLSTPSSIPTILSSNDGSTATPMGSFFPPPTTSPSVTSQTPRAQQHPSSLADAARTDASGNPRSPQNIASGRFSGNAHRSDQKAWPKLPGFAPPSSDAAVPSASMGAPIQALQTLANAADQAAAFANNSGDLSASERSDVSRPSLNGANTDGEGPSHRKRKRKRDTQANTGIHLRVRKQTKPDPTPRNPFPDVVTKGLVSEAEARELWDIGCHYFVPLFDKQYDVYESFLERTPFSTNGLLAVAAKIRAGNGPVGPTFQRCLEEGQGIARSTLFGPIVRKEAVMAMLILSVWSQYGWLPVGHALRMGLDINLHRALDKLSNDEGKRTEAEERDLVVSARIWLNCYLHENLLGTGKPLMLRDDSSVRGARILLLVARVELVNLRIRVLEQLTPLHGKVNSETISTVCNIFDDLQSWYLEWKDIHTENYSHNSSVLTHLLEVELGYAQLWTVCVALRGCQWDKRGLAFEAKDAALRCLEIYLRVPLFRGHLKSAVAFAAVFLLKIAMLYPDAVPLQSLISQVSEVAHVLSAECYAERYALTLKLMLASLRRKTGAASTVPGTPRGGNNLTEAMSLTSANNNDDDVDANIDGGLQSLLGLPSAEESFQASGASEPWPLFSDIGEGFAWPTEFSPSNLPSWIQDNDDEGNDDSFRLTSSVPSKDIDTTALPSRTAVEKQFGKAGDLGDRVEGKFDSVAGAVTGDKSKQAKGNLQHDKGQAQMNANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM18</accession>
    <name>K1VM18_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM18"/>
    <dbReference type="FunCoup" id="K1VM18">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM18"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="K1VM18"/>
    <dbReference type="OMA" id="YVSGWQV"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="415"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC97767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="552" mass="59800" checksum="62CC920D295613C8" modified="2012-11-28" version="1">MSSAEVKALQEQVRAFDEFKNQPRFKRTARPYSAADVITKRGSLPIQYPSDAMAKKLWKILEAKERGEGGGCTFTYGALDPVQITQMAKYLETVYVSGWQCSSTASSSLEPGPDLADYPSNTVPNKVAQLFTAQLFHDRKQNYTRATAIAKGENPGPKIDYLRPIVADGDTGHGGLTAVMKLTKMMVEAGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRYQCDIMGTTNLVVARTDSEAATLITTNIDPRDHAFILGSTNPDLRPLVDLMMEAEAAGKNGAELQKIEDDWVKAANLQLYPAVLAAAITKQGGNGDKFAKEAASNPLSNADTLALAKKHGLKSAPFWDWSAPRTREGGTQCAINRAIAFAPHADLIWMETKSPIYAQAKEFADGVHAKVPGQWLAYNLSPSFNWSAAGLGPKEMKEFVWELGKLGFRKWPLTVSLFQFITLAGLHSNAYISDKFAKAFAKDGMKAYVELIQGPEADEGCDVLTHQKWSGAELIDAQLSTVTGGISSTAGKFSVMRLAPAVISHPTLDPGHRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VME8</accession>
    <name>K1VME8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2804 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VME8"/>
    <dbReference type="eggNOG" id="ENOG502S8EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068418_0_0_1"/>
    <dbReference type="InParanoid" id="K1VME8"/>
    <dbReference type="OrthoDB" id="4763727at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868:SF3">
        <property type="entry name" value="DUF2804 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="DUF2804 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42432" checksum="BB76C727A1D7ECE8" modified="2012-11-28" version="1">MTNPLALDLDTLLTPTALSVGLALLSFGVYLSSTLLSSPHPKPNMPLNTTEHTASLELVNEGGQLNRLAAGWARGPIVTSELLPSGAWWGYRSKQWEYWGVISPSLVLGLTLADLDYGTVIQLYLHDRAANKSYTWEMPGIPPNRDLVHLPKTLPPFTCQGQTGQFKVMFADTEQAGKKITTLAAKAPASGTTPAVEMHLEVNTEGESFGVVVPWSDSRFQYTLKAPALPTTGTVKLGEKTYTVNNAWATLDRGRGRWPYRMAWNWGVALGQNSAGQRVGLTIGGRWTDGTGTTENALLLDGVVQGQGPLEDVAWIYDLKAPEKPWKIRGSWIDAEITPWHVRVAGAQKVVMSSFTTQVFGQWKGSATVDGKTVSLDGLTGWAEDAANRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMI6</accession>
    <name>K1VMI6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMI6"/>
    <dbReference type="FunCoup" id="K1VMI6">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMI6"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140672_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMI6"/>
    <dbReference type="OMA" id="WGINRGH"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="102" mass="11582" checksum="25983557F4629424" modified="2012-11-28" version="1">MARTNVAVGLNKGFPTTAIPKAVKPSHKKGIKTEKKIFVKSIIREVAGFSPYEKRVMELLRNSKDKKAKKLTKKRLGTLLRSKRKVEELSSIIQEQRRQAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNV1</accession>
    <name>K1VNV1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNV1"/>
    <dbReference type="HOGENOM" id="CLU_937462_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNV1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="298" mass="33279" checksum="16509B96446EDA55" modified="2012-11-28" version="1">MTQLKPQSRLSAVKSGSDAHIGSDAPHFPRTPDTTLNVNNRNSRTHPASFYDGHEFQSVANVLLRLEKAGCEVWAIAFNGNTLDVTVNAYDPYWLDKYDSSRPDPPGRDGREFPSRKRRSSGVNTSDSLARRVPHYCIQVTKAPRNDVLSASFPSAHRDSLAYRLDYILAYPTPYLCHIPHSMSPLSGSESPVEDEDRYVGPQVPDIKLNINNRDSLTKPSGFYDALEQMSIANILIRLERAGCDIWSIAFNGNTLDVTVIAYDDDWFANFNKSRGDKPHEEQTSAGALEAREQGFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNX2</accession>
    <name>K1VNX2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNX2"/>
    <dbReference type="STRING" id="1220162.K1VNX2"/>
    <dbReference type="eggNOG" id="ENOG502S342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048444_2_1_1"/>
    <dbReference type="InParanoid" id="K1VNX2"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33995" checksum="A47902096B0367DA" modified="2012-11-28" version="1">MAEPARRVGPMDNAHAQDWSVLDLGHALVSQRTIYLVDLKVDVWGVDEIAGSPLPVTCIILAHGWANKAKDMEPMAAGLLGEFRRLEAESGGRKRDVIVATLDQRNHGERRVNKSLQSFQKNPRQFGIDMSTALVGGKQDHELIMQFLSGRLWADGSRVISEWISVGFSMGGHLCWRLLRECPQVKLGIPICSTPSESLGNLLRAKVLPPHAPEVTQPPEVVHYFSQSHHEPNHWERYKGKKILAVHGQLDNVMPFRLGAESWEKLAPHTAAAERYEEPGRGHVCSPPMVRRAAEFIWKHSVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPF7</accession>
    <name>K1VPF7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPF7"/>
    <dbReference type="HOGENOM" id="CLU_1205524_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPF7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="230" mass="25401" checksum="FE574343D1DDE4BD" modified="2012-11-28" version="1">MAVSSASDSMAVIAFLVIICGTPVVILILVGCIWWARRPPRCLQCSYRHLPIPARVECPYVRNPPSFLRWFTSPLNASSDIEVTSIASVFPIRRSRRARREERPDEVRPRRLTTEEMEYWIQEMAPPLPVYLEHLPAHEILIERDGCTSPTPSYRSPAPSYVSPRSSLCLDYMGDGVAAPPSSPVVMGTVAAAARAEASSGAPLTALPPAITRKSMRTLQRGRWSSTASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPK6</accession>
    <name>K1VPK6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-selective cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPK6"/>
    <dbReference type="STRING" id="1220162.K1VPK6"/>
    <dbReference type="eggNOG" id="ENOG502QU70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009570_1_0_1"/>
    <dbReference type="InParanoid" id="K1VPK6"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF6">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="439"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="744" mass="81874" checksum="42C4BAB3AD4335E4" modified="2012-11-28" version="1">MSSLTGSSSSSPTKVQRSATASTLEQPVPTTVYGLLHELHARITADVDAVLTWDELKSPAFQFSVVKPILDRYTPDEATLAQAAKDDDDEDNVDASKSLGAVLYALMANRSARCTFTIAQQCDCRDYPVAPIDAPSFCTPVLAVLTTVKFLRTWPSPGDEALAAELVRPWSPLEGAPDEVWAAIENPDEAKADKNSALELAIVSVAKRLLSQPIVQHLVGAIYTGDLVYAPDVNRSLIPDSYVAPRRGKGHKAKRADDFDVYAYNPYEAGWLDTTRLRVPRWRHWIEFGTFATLIALFMWTLITRDLKHQTGVEIWFVLFTLGFIVNEWAGANENGWSGKLSFSEAVADDSVHRQRLERLRPVVHPDLLRLPDPPLHRTLPPQQAHCGPRLRCACLWRLYPASSPRVLLRSQQRRGHCGKSAPAAGSGVDKADPQLRGMIATYVSFMALAAVALSGVAFALYMLGRPEFSPLAIVKLMMKIWFGGGFGMSFGLAERFHEYFGPIILVGYSALCSTFLITALMSMVSNKFATINNNAQQEHLYQRVVSTVEGAKSDAVFMYLPPFNLLALVILIPMSKFASPETVHTVNVALIKATNFPILFAISAYERSRYRLSRRRIKIQERTGVCVDKIKTPGIFDSFFGGGNALTLHAAFDLATPEEPSSTLSPSLLPAKDEEDVPPLASEKKKKWKPTGSSVGRIFRSDGTAAGGKTVTVSKEEWDEVKASQARMEDMLQKVLTITAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPU2</accession>
    <name>K1VPU2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoprotein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000315">
        <property type="protein sequence ID" value="EKD01482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPU2"/>
    <dbReference type="STRING" id="1220162.K1VPU2"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1166551_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPU2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase BSK1-like TPR repeats" evidence="5">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="238" mass="26105" checksum="E6853937501673C8" modified="2012-11-28" version="1">MPPPASPAHRARARLSPPSSRTTSPPSPPPCSRRRSSRTSPVSFILRSQLTSVTSDSELDDIDESRVPTEAEKAEALQLKAKANAAFGKKDFSTSIELYTQALRLDPTEPTFWNNRAMSKAKMEEHGAAIADASKAIELKPDYAKAYYRRGVSALAILRPKQAVPDFKKALEIEPGNRTVREQLVATTKLIRRIEFEKVSKHSAAAAARYRSSKLRATGLCRGRQRWGECGAQGSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPX2</accession>
    <name>K1VPX2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03057</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPX2"/>
    <dbReference type="FunCoup" id="K1VPX2">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPX2"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_3_0_1"/>
    <dbReference type="InParanoid" id="K1VPX2"/>
    <dbReference type="OMA" id="FQRAYPM"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="902"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="954"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117444" checksum="47B2634AFF7CAC64" modified="2012-11-28" version="1">MPTLPRYLKKPSWWEQSMAVFFASLNFYRVHMMCFTFIPLIFSGIFYACNTEFHIKYVDCLFLCVSSMCVTGLATVDLSSLSTFQQFLMYFQMLIGSLIFVSIIMLSVRKRFFRLKFKHVMEEQRSKRRFDLAKTFTNFPTTTGQMTSALRRRFTRHHDDTEEENHSVPPTPADTIREKDHAKPKKKGPIKLTTDMIRRVDGGGVGMVNPMGWYDANTPTPGNQTPETNRSVSPPPMSRASSDGREPSQTGSISDPQTLRNDSDHSDKGKEEYRSSSEGKKTERPSDDLQTAPSLLKNFGEELRTAPTRTEDSIDSEPSRPPPSPRHKHVPVAYKPTPAEDDAFPRSKTIAFDEPEDGMDHELHFSNTRDPWGTGPSNFPRSATIRSDNSRFPRSGTTGSGFPRTSSLSRTGSRLVDSKMTGFGGFPTPLEIASDLFHKVFPKAHSKVKRTITMPRTETISGHQSNQEGRDVPYISFAATVGRNSNFQDLTEEQREELGGAEYRALKILWWIVSVYWVFMPLAGATIIAPYIAAGNRYDWVFNEQHKHVRIPWFAFFQSTSSFSNTGMSLVDQSMVPFQKAYLMAAVQALLILFGNTCFPILLRFIIWSIYKLAPTGSHVREPLKFLLDHPRRCFVYLFPSTHTWFLLLVVLTLTIIDWVSFMVLDIGTPDIEALPVGTRIAAGLFQSVAVRAAGFGIVPMNSLAPSVKVLYIIMMYISVYPIAMSVRATNVYEERSLGLFDDDDSDEEDEEEHEASETRGAHAVAKYVGWHARRQLAFDMWWIALALWLVCIIERNNLNRTDNAEWFNTFNVIFELVSAYGTVGLSLGAGSNNYSLSGELRTLSKLVIIVVMIRGRHRGLPVAIDRAVMLPRDFQEEDERQLESRLRRSRSRMTSTFGDRDQVLSQTGSGFPRTFTMQSTPATNIVPPSPMIARRDSSVGNPSSPGMAPQHVRSFSNTSDTPSPMSPQSPGLHFALQNPPRHIRSHSHSSNTASSPPISGANPNSLNINGLDTVEETGLSRLPTLTLSTSNIPRSSSPDGDAPPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ33</accession>
    <name>K1VQ33_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_02941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ33"/>
    <dbReference type="FunCoup" id="K1VQ33">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQ33"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_3_1_1"/>
    <dbReference type="InParanoid" id="K1VQ33"/>
    <dbReference type="OMA" id="YWARRTA"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD02711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="137" mass="14326" checksum="097CD9B2657C0BF4" modified="2012-11-28" version="1">MSSGGKSGGKSGSESKSTSRSSKAGLQFPVGRIHRLLKRGNYAQRIGSGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIVPRHLQLAVRNDEELNKLLGSVVISQGGVLPNILSELLPPKGKGGNKAKIPGSQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ48</accession>
    <name>K1VQ48_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ48"/>
    <dbReference type="STRING" id="1220162.K1VQ48"/>
    <dbReference type="eggNOG" id="ENOG502RSBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444951_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ48"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="614" mass="66416" checksum="FD97794A97C8A818" modified="2012-11-28" version="1">MQLHCLTGNRFELPLAGFTFLQTQIAPILAALSSVTLVLLHSTLSLGEVIPFASPTGDRTWDEQIEEARETGKLAPSTVLTLRRRPGAAAFWAGVSAVGAQLVIESFGLSNCIGMGAKGFSPGCMLFGLASAIGLTQYLGGGLSTRPDYACWILGTLWLTGVNESLDVVRRHEEGWLRLGRVSTAGRAVADHRPAILSCFLSYLATATSALFAHVHTLLILVPDLPPCPPRNPIKHLQLVLHCIMNPPEVDARLLSSLVNAEDGVDFNGGTVVNFCIVKRAFPRELVIPVIAVYAWRRATRDLLDKPDPSIPAEDLAARRRRALAAIQLHLVQAYEPESSALERVFTLTTIPGLSGQDHSAFYLFASLIPRLAPIYPFLEMCRAYAVDIGFGSPGQLARCLTQANANIHQCLPVTSHSHLEFYAYAVMGSLSESVCYLAWSVLDSTGTRPSDDMQWSAAIHPAVSRRVLQPGAPLPTLMRAHTVAKSRDIGRAIQYIAVSRDIVKDAAKGRLFVPLCSFKSPRELLQTLLPGPEHAPPSHVVLGLLDQAEAFRVGTDMGINGLPRAARGGARALVASAFQVVGDIRRNGGLVDMRGCCTCRWRHVVATAKGLWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRH1</accession>
    <name>K1VRH1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRH1"/>
    <dbReference type="STRING" id="1220162.K1VRH1"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392413_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRH1"/>
    <dbReference type="OMA" id="TSCTTFE"/>
    <dbReference type="OrthoDB" id="2533523at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="7">
        <location>
            <begin position="82"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="703" mass="76122" checksum="1222712F3DA3A8BA" modified="2012-11-28" version="1">MPAPGHSGTGVYHPNGHSDPLKPSRSATVAGIINNLAQAAKPPAPKPAPVKRNSSADSDVSSASSTSVSGKDINGTHVRDVFRNTANSVWVITSAWDGEPVGYTAITVNSVSVEPPMITFNIGRSSSSLNTISRSLKFAAHLLADGETAAAKRFAADAKLRFADKSTWSWHEDGLPSLSNGVLARLAGDIVNLSHAGDNLLVLGRLENIDIRPGQPLVYHQGSYRTLPDPTAQLSLSPPKKDRRIYLNAFDMCCVGHQASGMWSYPGDKASTYKDLEYWTDLAKLLEGGGFDALFLADVVGIYDVYQGSRDAAVRSAAQVPVNDPVGPISAMAAVTERLGFGVTVSLTYELPYAFARRMSTLDHLTKGRVAWNIVTSYLKSAATNLGLDAQVPHDERYNIAEEFLEVCYKLWESSWEDDAVIRDWRSGVYTDPAKVHDIEHKGKYFNVPGAHLCEPSPQRTPYLFQAGASARGQAFAAKHAESVFIAGPNTTHLKRLTKGIRQSAVDQGRNPADIKIFALVTIITGPTDEAAQAKFEEYKRYSTVEGALALYGGWAGVDLSTLPLDQPLEYVENDAIRSVNEMWSKQGEGGEVWTPRKIGEKIAIGGLGPVAVGSGKTIADLLEKWVDEADIDGFNLAYAVTPGTFEDIITYVVPELRHRGRLPNHQKAKKGERKTLRESMGGPNATAHVSPDHPAYAYKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRK4</accession>
    <name>K1VRK4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRK4"/>
    <dbReference type="STRING" id="1220162.K1VRK4"/>
    <dbReference type="eggNOG" id="ENOG502QT5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1267694_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRK4"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20590" checksum="6E58FC5FBFD28A03" modified="2012-11-28" version="1">MPIDDRAGRSSESSDPERLNTHDEAPYLAPDAPPPAEKPTFLRQTAHYAGLVLAAMIGTLIRLGVDALMEWAMLRYALSKLNARPGFENRFPIGTFIANIAATLIIGGVFAAQRRPGVGVVRCDALYALQQGFCGCLSTVSTFAVEARSIKGKRWKLLYVLGSVILGHVLILGVVGGVGWTQGYVPVCFGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS12</accession>
    <name>K1VS12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000254">
        <property type="protein sequence ID" value="EKD03386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS12"/>
    <dbReference type="HOGENOM" id="CLU_3034059_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS12"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="55" mass="5843" checksum="92C0EAD72585F94D" modified="2012-11-28" version="1">MTTTPQGDLQAKPQRVQGLARGSSDLSLTFTRSPPEPSPPLMQQSAHGSPTVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSC4</accession>
    <name>K1VSC4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterol 24-C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSC4"/>
    <dbReference type="FunCoup" id="K1VSC4">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSC4"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="InParanoid" id="K1VSC4"/>
    <dbReference type="OMA" id="NGIATMM"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="35049" checksum="1AA6DCD6688C51FD" modified="2012-11-28" version="1">MPSADARSEARVSNYTKFWKKDSAQDGESDRENRLSQYTDLVNGYYDGATELYEYGWAQSFHFCRFYKGEAFLQALARHEHYLASMMGLRPGMRVLDVGCGVGGPAREITRFTDAKIVGINNNEFQVGRARQKTAKAGLSDNLSFVKGNFMELEKQFGANSFDAVYAIEATCHAPTFEGVYGEIFKVLKPGGTVGDGIAEMRTIHAARKALKAVGFEIEHEEDLAARDDGPAWYYPLEGDVFKAQTLWDVFTVLRTTTVGKFFTQNTVWGLEKIGLVPKGTYDVGESLKVAGDALVAGGKTKLFTPMMLFVCKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSU2</accession>
    <name>K1VSU2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-1,3 glucan biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSU2"/>
    <dbReference type="STRING" id="1220162.K1VSU2"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401239_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSU2"/>
    <dbReference type="OMA" id="TEETDSM"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="686" mass="73487" checksum="5C8B4A7EC8B27D3C" modified="2012-11-28" version="1">MQCTITAPANASQNPQDSPGPSRRASGQFPAGPSGAASGANYPPLSHTFYRLRNVLAGSYPELIESLNFPATQEALQEFEQMLGSPLPPAVRESFLQADGQDLEANNPAGIFYGLQLLPLDEAIREWTYWRQVEADPSTGANPAVLATMASIPPKWIKSEYASRGWIPLLSDRSGNYVGVDLDPGPGGAWGQVIIFGRDFDRKCVMWRGDGDCGWGTWLSSLVDELEAGDAWEVDNGGSDDEEEIGYESYTGGRVYGEGAGLGIMKLTGEYKGWAVLEAWWDRSVGHWEKQGLGMDVEEIERGLEESRRLATVPEENGKGKAPERSSLDMSAIRADYVLETPLERGNSTEETDSMLRPTSPDSNAIPRILHPPRHSPSRPQSTRPSEPSTSASARMSVASSSTDDHPLKPDSEFLSPPTAAQARKQKRPPPPRPVMIDLPTRADVQAAQAVALAEESGLRGGWVMNLDTSAGAAQRRARGHGVSPSLDAEMVDIDLEAGRGDMFGASLTAAELEKQREEDRLSLAGIEQRRGSGSRSPSLLNMVSHRAPSPLARSTAASPPVEGSLPSPLIRSPVSATSPPPNPNSIRVPPTARSPSPAVPDQEREVVRAGSRRGSTVVRERENSSDSRAGLLERTNSGSGRNTPSNSLDKVLSPTSTSDGVAGNLTEEPKAIADLADGMEEVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSZ2</accession>
    <name>K1VSZ2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSZ2"/>
    <dbReference type="FunCoup" id="K1VSZ2">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSZ2"/>
    <dbReference type="eggNOG" id="ENOG502QPT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="InParanoid" id="K1VSZ2"/>
    <dbReference type="OMA" id="QCTELAW"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="255"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="492" mass="54279" checksum="9C1BB43ABC21004D" modified="2012-11-28" version="1">MRFHVLGIGSIGTLVAHNLRRAVPSAEVNLLQRRAKNLRGKGKETDKERNLTLEVQRHGTKTVSSGYVVDLTKADWPGKEHFKTELEEQGIAVSAGGPIDSLIVCTKAQGTSHAIGEIADRIQPSSVITLLQNGMGVYDELCAKYWPDPGLRPQFILGTTTHGVTPGERNGSILHMTKPGDGALKLGVVPDPRGKTSYDRWLWGSAASRIPSVGQPIAPTYPLPKLNAEPNVRETLNAFLSMTELNPEVLPMANLYHELLLKVAVNATINALTASLGGGFMRNGDLVRSSPGFQLIKQTAAETSAVLQAYLRNLAGGHPPEPEVMRLFSATSLEDRIKSIATQTQDNTSSMAMDVKAGRDTEIDYINGFFVALGTKLGVPTPLNRMLVQMVKLRAEMAGLGNTFLPPIVDVIKRRERKMVNKQEEKLARRALSLEERRLSLERIEQRESELEKRERRRARKSAKRQRVREQEAARKLATVEMPPVVMSSKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTE2</accession>
    <name>K1VTE2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTE2"/>
    <dbReference type="HOGENOM" id="CLU_657536_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTE2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="46027" checksum="BC1C8E657A98E0B5" modified="2012-11-28" version="1">MSEQPADDDKSRPNSTAASSSEATVVPWKSWSLGQDPDEDMQEQDPTLLTTNRLVSVRLSDGSSLGPPHAEEERTRTISGKSMATTATSRTSWQTQGSNWQPEERTQLDDVLHFAPVEFDTHLKIPSSFNYKRSSRASKASRTSRISKTSKISKLSGVSGSTHNSRSASPAYLTAEDFGNGSSINDRHLSRSSYYTSDAATSTNTHDFTDARPHSPDSSYHDDLDSYQTESESGSETTHECGPPEPKEDDVTGEAVPSPSGPVVPDSGDEVPSPPPPPDEPQPLADEKEAEKEKGVMLRRESTTRSLLERIALQHVMNNKALPPRPTSMPGRPRSTHPRPKSMALSRPSTKSVKSEKSMRSNAYTQPSIASVTQTYSKYRIQSGHRPNDSFIWVDSEAEPDYANMTPVRFWIVFIAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU06</accession>
    <name>K1VU06_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU06"/>
    <dbReference type="eggNOG" id="ENOG502REAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495225_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU06"/>
    <dbReference type="OMA" id="FFPVRIY"/>
    <dbReference type="OrthoDB" id="2562734at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="519" mass="57054" checksum="3622620E56191E07" modified="2012-11-28" version="1">MPKRKATSADLSRVAPPSLSSLDAALDLLAHETFDRLQTLTSKFEAAAGVKLNDGVVKARWEEAVKRYWVMKSMDDLCCSVNGTGPGVTLEDSPGSDDAMRDDSASVSAAASTFESDGDEEQQWRKWAPKLNDVVLVELQKGGIWPGKRVFLQGRQSVPRGNHFFPVRIYNEEIEPTLTVKSRMIPFHLRSSAPLMASEALLGAYNHAANPGPFDIAAGNRESAAAYSRTHPGVNLDEETTERVQKQKESWKAFVNWLMDERRLEKLRTLCEERDKRLKEVANQSVIDLGGFNTLDGEERPCSPRKRQVTCSMPPFTYSSTSTRTVQKIESDVTERGGIFRVKSIASSSASSPYTGPSQSSPGSSPRVMSPMASYIRPALSIPYRSGSPRRADRRRNIAFSSAGESSPRRRSGTFTPPRGSPSNDEPAPFASPSPAPTLRSFGFKFGKQMTEEEDDQMNGRGLGPVTALEAVLEEREEEESWTVVAGRGRHKRSGSAPLNRPKEQPPEPSATASDDMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU55</accession>
    <name>K1VU55_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000235">
        <property type="protein sequence ID" value="EKD04061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU55"/>
    <dbReference type="FunCoup" id="K1VU55">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU55"/>
    <dbReference type="eggNOG" id="KOG4657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093947_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU55"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="185"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="31929" checksum="C22A436979518C52" modified="2012-11-28" version="1">MTMDGLNPATFDLSRFLSAEAPVLDFGWEKFEKKIYKYMAARIGGAHQDIAQRAHDYDQNIANIKQDKIITDMEIKQEQENEKVMLQGELSPGDQRPRGPGARVARERRAVTHLQSSLSRFQASLQRVREQNAALEAQIMSLKNEVGSERATKERQAKVLADMRARDARQLSVLEGALGLRMEGVGNDRLLLLFTLIDPSSPEREFRLVLDFAGGHYSVPQCDPPLAKLGTLLEQVNADRDVHLFIKKVRKEFAQLVPPEGGRFDDIELRRKSIRKSVLSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUG7</accession>
    <name>K1VUG7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dimethylaniline monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUG7"/>
    <dbReference type="FunCoup" id="K1VUG7">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUG7"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_3_1"/>
    <dbReference type="InParanoid" id="K1VUG7"/>
    <dbReference type="OMA" id="LYQHVVW"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65221" checksum="652B9938B4223687" modified="2012-11-28" version="1">MLSFAITPLSHRSVFFSTVKEPSVQAKEEQRRVSARARRCVLSVRDGDMLGPTGWLRHRSRPRPRGDVPVKPSRRQRQRQRLETKADESTDQKMGEQQQSQQRQGKKRVAVIGAGPSGAITLDALVKEHAFDVIRVFERREAAGGCWIGDTAPPPTLRDFTSLAARTADPPIPLPPSLPLQTAPLDPAQYPRFSESSIYPYLETNVDAIPMSFELEPFPSTTTEWSRGHYGDSTPFRPWTAVRQYVQDVAGLHPDYVEYGVTVERASKVGDEWELVLRKGGCEVDTWWTETFDALVVASGHYHVPYIPPIDGLEEYEASRPGSVIHSKHFRGRELYAGRRVVVVGASVSAADIAFDLAPTSTVFAIMVGRTFNAYFGGGAFEHPRITQCVTIHRIDPKSRTVYLQDGTEIPQVDHIIFGTGYSWSLPFLPQIKPRNNRVPGLWQHIVHQDDPSLLFVGAVGAGLTFKIFEWQAVYVARLLAGRSKPLPSKEEMEEWEEERVKLKGDGPGFSLVSPDFEAYFELLRELATEGRTAEGVGRKLPVFRREWHRAFSEGHELRKGMWSRVNALAVQELQKTTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUY8</accession>
    <name>K1VUY8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUY8"/>
    <dbReference type="HOGENOM" id="CLU_1027404_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUY8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31019" checksum="6EC0E421827420A1" modified="2012-11-28" version="1">MFATVPLKVPVPYRSTTSPPTRLRLRFSGDLSLDVSTFLRVAEADMSRHPFYFSYVLLRIHFLRLSCEGRGALWVDRYLGSSLLPPSLRSPLPHESISEWIAANDAAWAGFREDMLDFFKDGTQAQLRGLQQEGSVGQYAELWRRAAGDADVPVDSHFNCRWWIWGLKPDIRARFTDDDWSIPSLEHVVAVAQRVETELNRAQRPYTFHASPSRWRSRLSSEPVLSGLPSPIPEIGEQGGSRRRRRATELTNRRRSRESSQWTPLRPTTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVB1</accession>
    <name>K1VVB1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-binding cassette transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_02282</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000250">
        <property type="protein sequence ID" value="EKD03427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVB1"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="InParanoid" id="K1VVB1"/>
    <dbReference type="OMA" id="KNPRQGA"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854049" description="ATP-binding cassette transporter" evidence="13">
        <location>
            <begin position="19"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1048"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1281"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1305"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="350"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="695"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="1051"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1366"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD03427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1647" mass="182186" checksum="851A3FD223F7E312" modified="2012-11-28" version="1">MASTFAIALTALIPFTSLVSFSGYLTTAEDSPLYLLLHRRGVQLPTNDGSLQPQADPFEIEDPVTLSDGVPVREDSFWRHERMLKIWLLVSMVPPVICNICLLIFSLISSKGLEEHERARTILLPILLTPAHVITVVLALKYLGQNKTSTHWPTTWHLFAGLSTQFIILTFLAILPSTPYPRAPTDFIPHAFLNFSRTDTLKMPPLTSVGVLTALLPVFQWFPLWAIISMRRGPPLHMPMKDVYPAKVVESIPPDAKGLDPTVPNVSGEAQVTVVEWFMFSYASTVIDKAKVSDSMDVWDLPILMSAMRAFPNYLAFKKVYGRRRSRLGKWEGYNLLLQLAKVNARLLTAMVILTVITAVGYYAPHKLLQWFIEYLQVDPGRTNVGWGWVLAFGLFISNAIIYILSGLIWSISSTYLQGRFKLQLNTMLYAKTLRKKDVAAGGDDKGIVGDVKEEAAKAKAKKERGEEDEEEDEEAVSSKSQIMTLFTVDVDRVSEFIFHLFTIIDAPIEILVATGFLFQLLGTSALWGLLATLISMPLTHVASKIVVTAQDNLMKARDQRSALMNELLQAVRMVKFMAWERPFERRVNQIRRSELSWQARNYQIEVLFNCIWALTPVMVTIVAFMHYTLVRGEKLTPAIAFTSIAVFDELRFALNALPEMLIQMLQGFVSCRRIEKYMSLPEVPDVDPFAGGDIVLRNATYTWAKDESKSPTKSAAPTPRPDFSLADLSLCFPAGKLSLICGRLGSGKTLLLSGLLGEADLVAGQVEAPRSKPDAMSQAEDKLTSAEWIIKDNVAYVPQQAWLQNATIKDNIIFSSPWDPVRYAQVIEACSLTTDLEILEDGDETEIGEKGLNLSGGQKARVSLARAVYSRAGVLYLDDVLSAVDAHTAHFVMENCLQGPLMADRTILLVSHHTALVSPGAAYIVALENGDVKFAGTRAQFVECGLMKELDAEDPESQPTAGERAEERTIEELPALKHKSVVSLSGAGPSGSEPGSETSSITDITDDSIPAPPVKTPRKLIEDEKRVRGRIAWSVWQLYFRSLGGPMWWICFIASIIIAMLVPVAERGWVKYWAGADDRDSPAHTAVFYVVGYAIIAGSGCILDNVEFAVTYIGSLRASRLLHAKMLQAVLFAPLRFHDTTSRGRILNRFAKDIEGLDSSMADNFVRTVRYGCNVAVTLTTVAYFGGWPFMLGAALTMIVYYRAGSVYGQASRDMRRLDSVTRSPLYSLFGETVSGVAVLRAFGASTVALSHMMRLSDTNILCFFWTWTINRWLSARFNILSSALVGLTAAAMLMAPVSAATAGFALAFVSTVMHNLLFVVRRFVQLEQSMVALERIKEYSEIQPEAAEYVEPGPPEGWPAKGEIEVKDLVIKYAPDLPDVLHGLTFNVKPGEKVGIVGSTGCGKSTLALSFFRFVEATKGSIVIDDVDISTLGLTDLRSRIMIIPQDPTILSGTLRNTLDVFDEYSDAEIYEALRRVHLLTEDAMQPPAPSAASSSEATVVGERNANVFADLNYPVTEGGDNFSTGEKQLLCMARAILRRNKILLMDEATASIDAETDTMISETIRTEFTDSTILTIAHRLHTIIDFDTVIVMDKGSIAEMGSPYELLRKKGRFYKLCKATGKTEFAALKESADKAEERRKNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVC2</accession>
    <name>K1VVC2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">holocytochrome-c synthase</fullName>
            <ecNumber evidence="3">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_04915</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVC2"/>
    <dbReference type="STRING" id="1220162.K1VVC2"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296501_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVC2"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="19">
        <location>
            <begin position="163"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="16">
        <location>
            <begin position="827"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="18">
        <location>
            <begin position="958"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="506"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKD00723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110570" checksum="BFC3BDCCE2086F2F" modified="2012-11-28" version="1">MSATYPERLEREGSHVDESRIDSELEHQLRRRNVAHAEREAADQLGEPEPGNVAASGPAAGEYPSTGASTAHSFDTQPKNSMQEQLTPTPTVPLPDEGGQDAALQSSTPADGASAAALEINPAAQSAETGSKDTPPANAADSTAANATAPGTAPGTTGAGVIDEEGKERSCRICFGGVDEEGEMGRLMSPCLCSGSMRYVHVQCLAMWRAKNSKTFLECPQCKYTYVLRRGKWGDFILSSRALSLATAATFISMSLITGHFLLHFLLNLYQKGSHSSSAMGSTWESEDGTMVVYMGGATFILDLIDDSINAFIAITAQAFDMFEGSRWVSPLMLDFILRFLLGVALLGALSALSLLGSLRLLAPLQLIYTISLSGVISLDPVLSALGGSRSIIVGFVLLGVANSIVQVYDALHACAMFGLRFVESEIVEPTREQVTQATTPSVMKFNVGADSTQATPAAPKTCPEGMHAKPAAAMPADHPPVPAGMGADACPVNDDARKVWTDVAEQASKAAPARPQRAQLSTEREISSIPRSSHSQYTHNSEQAALPTPEEEQTDKWVYPSEQQFFNAMLRKNHKPRQADMRTIVPIHNAVNEKAWEDILMWEAGKGGDRCGGVRLTSFVGRPKERSPKAWIKTMFGYTPPFDRHDWIVDRCGTQIRYVIDFYTGKPDPNNPQKMAFYIDARPALDDWESIKTRLSGPASSRPTQLSPPARSGGQAAKAKRWMMTVCHGSFGASESPRVHRDNYSPLYFPTQPPNLSFSAFDSIVPPLSGRAAMSQFKNPFKRAQQENDSGQITVHVKWGRDRPHAAPTSRGLLLVADNRFNIPIPNPSLTPLSQLIGTLSHQTGVPASQLKLIYKGAVLKDPSLTISSYGITDGADLALVGKEGKGPEPPAPKPQQVVKKKNVQPETDQEDVLTDWIRGLVNGVVEPLEPAIATFVSYTNPKATNRPKQVPPFETLQREHARLSELLLRGLLDLDGVNIPSEWKNARQERKDGVKRLQGELNKVDDSWGERKRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVI0</accession>
    <name>K1VVI0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVI0"/>
    <dbReference type="HOGENOM" id="CLU_814291_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVI0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="341" mass="37128" checksum="1151AF3144B1ED79" modified="2012-11-28" version="1">MHESHSGHPHATSAVRDGCEIAAHDPAASAVVGVVLTRTRSLISRALWVPSEAGSSDGFPVTSSPTGGLVSTEYDRADIEGGRFAPTYADIVGRQEPGYGRFALFQLLWKSLSLYPYVDSSSPPSRAATSPADDAPRSRYLALEPRADRWTDTMAQCARGRKTCHQVANLDLANIGIRARLLRFVLDEPPVRTMDVTLGWVAENGRAGWALPCPAESPATGRVLDAALDMFTRNPWRRNGLVQLDPPPTLHSRAEASGHLERQRCPNHSCLQQRLPTFFLLVDHLAVGGWLRGAGCEYWELPVGVDRGEGVRILLVLGAVNVPLEISGDIPSRRDSLYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVK1</accession>
    <name>K1VVK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVK1"/>
    <dbReference type="FunCoup" id="K1VVK1">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVK1"/>
    <dbReference type="eggNOG" id="KOG1554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302103_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVK1"/>
    <dbReference type="OMA" id="VANIIWR"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG-I" evidence="5">
        <location>
            <begin position="399"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="988" mass="109787" checksum="05F409C16A8C054C" modified="2012-11-28" version="1">MEDRVVKISAVALIKMYEIMGVMYGRVRDHAFWITDAAALPVQGTETRVNAGNEFQESNKTVGKNDLLRGWYHSQGYTPPASGSSEYQTIPLDKIEDFGAYANSYYPLKVEIYKTKTDKKLLDLLWNKYWVATLSQGQILTSRAYTTSQIKDLNAKLNSAGSRLGEQHAALKIKNSDAKDKKQEDSVEIAPTAISGPAADARVPPEHLMIPSLDHCLPQPHSKPAPSPRHLGLYSSAAGCCPVIASTSVIRDARHARSQPRWKLAQTAPLSALAGTRLGIDVTYYVKQLLQDADQREPLIASTGGLPLSLANRIESDLRQLDKAGIKPVFVFSGLPLTSRPPTKGTNNQAERENMVKNEAWSYYEDGQVDRAVVALTQVRGGQWVDVQDVVRLILRAFKHRFVEYVIAPYLASAQLAYLLRHPKGYIHAMWSDSEALLWTVDKVITNIDWSGTFTFYEKSRILSDLGMTADQFLDLGLLAGCSLCRTFPPIADTFSIRSAIDLIRQYKTGIVTCQAWRESPAVKASNYGEVFMRARLAVKYSLILTTEGACVPLPLVVPPPNAVITPADIPSDLDEIFSPRLPDELYFFICRGMVAANLVGYLATGVIDERQPLADSPEYRRFIKDIITEGATSPLAHPTNPQSAHYYFDPAFAPVMGTAVPITDPLTQSLVEKCATWKVPHHVLGDELRRQSLCIGTLEKDETIAYTKKEKAAKILEKKDEIVANIIWRFLDVRGHHQTVMGKAFHAACNSARVTDKLQEPIYIILELLRAGVVHGHRFGGPNAPVLSGGPSFGTDEEQSNTLLIMRVLSAIPLNFRWSGPLSRELLVFNSFVKSTTKALRHLLEAINVHILLSGDARRMRDDYLDMCISLPFQVDVNTGFGILAKTYLDAATFHYGDTITAENAQTDEVKQAKKAALEFVDQAFTGVKAPTHEVERGFRFWDAIMVAIRTLNQEQGPNPTVANTVIQPDVIEQFERADKWLEPMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVQ3</accession>
    <name>K1VVQ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVQ3"/>
    <dbReference type="FunCoup" id="K1VVQ3">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVQ3"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_2_0_1"/>
    <dbReference type="InParanoid" id="K1VVQ3"/>
    <dbReference type="OMA" id="CARVQIH"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="17676" checksum="6504227989AF7CEF" modified="2012-11-28" version="1">MHLLGHHLADYKVLKYALRKFFGISYSTADRLLARLSIPEKALVSSLTERQVTALSSYLSAPSTSTPPGPTPVTPPHATDAQVRAALEDAKRKGPDPMDTLEIESDLRRNRKADIQHLADVGSYRGRRHAMSLPVRGQNTRSNGLTARKLNHLKRRNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWV8</accession>
    <name>K1VWV8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWV8"/>
    <dbReference type="STRING" id="1220162.K1VWV8"/>
    <dbReference type="eggNOG" id="KOG4036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067596_2_0_1"/>
    <dbReference type="InParanoid" id="K1VWV8"/>
    <dbReference type="OMA" id="QEYDWIG"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="187" mass="21062" checksum="7A634AC65FD46931" modified="2012-11-28" version="1">MESIETSGSALATGSINARFISQNKLDEANDRRDQEWKEAYARWVAFGRLEEQRLLKQEEWDNKMKLGNQYRGLHADEYDFLSEKMKEQRDKERRVKDQDNAEVMDALAKKYAAEVAAAEPSIPAASPSDLKPTTTAPAPKRAPPKSGKKDMKSLLKGVVVKKKPGTGTVAKRRTEGDETPDKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXD4</accession>
    <name>K1VXD4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000142">
        <property type="protein sequence ID" value="EKD05161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXD4"/>
    <dbReference type="FunCoup" id="K1VXD4">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXD4"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="InParanoid" id="K1VXD4"/>
    <dbReference type="OMA" id="CKRITFY"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="373" mass="40583" checksum="1893DB0D805B52EA" modified="2012-11-28" version="1">MPYDALVLGAGVYGLTIATELADRGVKVAVVARDLPEDLTSVGFASPWAGCNWCSFETDGSTPAAEWDAITYKYLGKLSKEHPDLCKRITFYDVWDEDRGKPWYSDLVFNCSVEKGSPDSPLPGGFPFGAKFESYILHAPNYLQHLAKKLRERGVPIIRRRLSALDEAYDLPEVGPVDLVVNSLALGNRTLIGVEDEAMYPAQGQTVLVKAPLVNRCTMSTGTVLSKSTPGEEIAYIIPRPGSEGHVICGGTYNRNNWSTVPDAREAERILKACYALDPLLAGPNGKSWRDIEIVAHNVGLRPSRDGGVRLEVEKRTLGENKILVPKMAGQRRRDVTVVHAYGPGGAGYQSSKGLAEKAADLVMQNVGARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY69</accession>
    <name>K1VY69_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY69"/>
    <dbReference type="HOGENOM" id="CLU_306125_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY69"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="968" mass="103337" checksum="0DF6059C94845E61" modified="2012-11-28" version="1">MLPRGHRPTGPSPAPVAPATPATQGGAPPQQQWGHDLHHHDQIKLLSVAVRQDDNNPEHFIKSNSSQTQLSLHRPPLRRVPTPLDPSLALFTKPKSVIDTSPNPSSAFSPVATESVRQVTDPFPASTTKEQVVHYPAPAVDCAPNAPRLANHFSPAPAQVLRAPFPKQITPAVTHDAREAHSAQARPARDYRDRDLDREYQAHNRARQAKPFPSLTGGLHLSHSTHGPHDPRSSLDLDVPVSASSEFDHSYWSTDSHGPASQASHSNHGHAQSAGTPYASHSYETGSPYVPRAEKDARYASDARAPRAPHPPLSAAPLARPALGARPHPLAGPYHPYSAYGPSGSTNSPCGPPDSANDGPKPAAAFPSVGQAGFLKTSLSSPTRAVPASSHSTPTTPTTPSPTRRRPSFSKSFNNLREHFNRGRSRSFSDQGHEQAASLPPVPRVPSVYLDLATDPPRHLRQDNSSMSLLRKMTKKRDKEAPKVAPPSQGQARNILAEMGAQSEQLRRRPTLPTQPQKIPAGTAQPPSAPPSAFQQGGGLRSQGSIRSAGARNVLKEMGAASDQIRARPPGSHPGRPGPRSRPRPKRQGTFEAIVVGQLPPQDDDEPPAHADALAKLTGEPSGVPIRQPPSPDTDSSSAQSTPPEVSLLGLEIDPSALRKPAAIDIDPTALRQPALAYDDDVGLPYDAPVADEIVLGDAYGSSPSDYGGEDLIDSYLDRSPSPEPAPLPPVAQVQHVPQVPANLVPGQVMPSTIVPGQIMPGQVVRPAALDTASPDVVEDHTRAFLAARGLPDSDDEKSSSDHAAVRPYGSESGHSSVQSHMRRAYGSDIGHGSQLSHSASVQSHGSVRRARPEHKQASGNRSRSSSRARERRDSSEKESGSGLFRKASQLGRKLSTKHARKWSREGMPPLPNGPPTSYNASAMSQAEQNLERKSCKPTIHTSASLATEISQVRNKDDAAQMEALFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYK1</accession>
    <name>K1VYK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000030">
        <property type="protein sequence ID" value="EKD05671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYK1"/>
    <dbReference type="FunCoup" id="K1VYK1">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYK1"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="K1VYK1"/>
    <dbReference type="OMA" id="THRFKPG"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD05671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="136" mass="15457" checksum="2D352332EF618EC8" modified="2012-11-28" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIQPKDLRLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYX5</accession>
    <name>K1VYX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYX5"/>
    <dbReference type="HOGENOM" id="CLU_1518919_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYX5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="20028" checksum="2FB0FB6C9E09047F" modified="2012-11-28" version="1">MARTKQTHPRAQPSTTKKRKAPPADAAAGTPTRSIRKGAKKVNPEEVAALQKALKEAEEKLEQAQEARNKIAAKLEALGQVVVVKPWTVDHLETDWASSLDDFRQTYGEFGEYEDELDDDDDAKRWIIRLLTMHDAIQGEFPSDGTGYIDEDGQWVDFEATDQDLEEFEWVDADPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZW5</accession>
    <name>K1VZW5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000290">
        <property type="protein sequence ID" value="EKD02358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZW5"/>
    <dbReference type="STRING" id="1220162.K1VZW5"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055000_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZW5"/>
    <dbReference type="OMA" id="FAMCIRT"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="30386" checksum="9B8FA6676E072886" modified="2012-11-28" version="1">MCRQYPHFAGLKLAHQRQDSSRPSTPGRKSSTPSPAPLAPVTPLASPLAHRGRSDSQPFETYEVELAEPTTDDDEPHSPRGVDGEGDYLRSKLWWAGLGLMGLGETGNFLSYGFAPASVVAPLGTVALIANCFFAPLILRESFTRRNVLGMTLAIVGAVTVVWSATDSKPRQMSPDELLQAVLAPAFLIYTGLNILLLVPLTILSGTQYGARWIGIDVGTCALYGGYTVMATKALSSLLSAVFLKAFAYPIAWVAVVVLVVTSVLQIKYLNRALMRFESKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0A7</accession>
    <name>K1W0A7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0A7"/>
    <dbReference type="HOGENOM" id="CLU_036013_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0A7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="436" mass="47587" checksum="53C400A7A9685DF0" modified="2012-11-28" version="1">MVAPQLRAAPLVSFPRVVPSPSPSPQTPIKRLGSPYHTPSTPTPPHTPTSNGQLRPYHTPRSSRSLGRRQCVLDANVHPYLVVRIMEWADPSVLRAFRAVLESTEVLDVAGRLSLQTMRQLRATAVNAQMYRVHIDCENTHLLSEFEQGKRVTLALHLGPGVAALPPQARGFGAVRRMIINVPLIEEGPFIPPPLIPMAQERQSQDQSQGQLEIVIVPSHLETMDPDRALQSIRTAYASAITFALALVPGSSPTILGLDESAHTRLGISDSEVEYLLRLEMARLETLLTSSCPTAQHDGIRHSLAGINFVSRGTYIKRVGEAHFRLESAPTRFRGNEIHEGDERYDDSFSLVEGSSSLALGGVGGALEHLLLLQQAHGSRAPDIPAGAGGGDGLSASPSFVVVDAPEGAEHYFPAPRRRLTKRQRHRRRSSLCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0L1</accession>
    <name>K1W0L1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA repair protein RAD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_03159</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0L1"/>
    <dbReference type="FunCoup" id="K1W0L1">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W0L1"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="InParanoid" id="K1W0L1"/>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="448"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="815"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122248" checksum="AD9CDF25A8B62B52" modified="2012-11-28" version="1">MSKSDLFFPAESDEEEEEFQFVPAGPSSQSSPRKTSRSSSTKESLFIPEDDDVVAVGGTSSPQPSSSKRKEMEPASSPPESGIRPGFVRGYLGEFVCEGWSLSKGKGYCSPGSKIVFERPNQKKNTAKNDDGHQKIGPARLVNGKMVQAKSKIGGKQMSLKSMMAKKPPPAPVRKAQQKAKVDQIIRFRNERGFVELEGHVIDCPQVLSTGSTILLNVRVYLARKGFRKVEKKDRSEAGTFWQEQQETEEEEAMRNRKEALGSLFGVKPLQSNSLIQAQKKGASAAAIINEKSLKHFETGKQSPRKGSPRKSPKPESKPQRDDGDEEEDSGDEAEKLDEEQMNELDNIYRKAQMNDANLDETDPPDSFLYTLRPYQKQALTWMMAREAGKDNLREGNQTLHPLWEEYAFRKEQDPGEPIEIEDDSDWIDPARKFYWNPYSGELSLELPRAENFSRGGILADSMGMGKTCMMASLLHQNRGEDEAVSASPVKEEPSDTKRRKFVQVTLSNQWRATANTPKPTRKPPRATLVVCPVSLASQWQEELGKMSAKGSMASALWYGNDRADIGQLLAAEGKKKIDVVITSYGTLVSEFARWQKNKDKPSYDHSSIYDPQVSKACYELKGRRRWALTGTPIVNRLEDLYSLLFFRSFVTIPFLNRDPKALNVVQYILESCLLRREKNMRDKDGRLVVDLPPKTVDMQVLDFSRAERQIYKHLEERARRRFIELDADGKAMSSYTSILAMLMKLRQCVDHPLLVMSKTATEDDDGDKLLEGRAGETSVKELLADYAGQREGSSDDAYVQQVLKELGENESPECVICYNEVQDEVLLPCFHRGCQDCIVDYIGHCEDQGKEASCPTCGKGPVKATQLRSVQRRRKRVHAFAEPASQDETVTIGKVDLVQSTKLRALVRKLAQLREEDPTFKALVFSQFTSFLGKLRHLQIQTDDRPHRADVESRGRALAALRWEHEPGAACGDGRAVRRTLFGADRASHLTQSRRDVFMMDTWWNEAIEQQAIDRVHRLGQSKPVFVTRYIIKGTVEKRIMKIQRSKTALVNASLSGGGKDKGQTLADIKKIFGLDDADSEDEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0Q8</accession>
    <name>K1W0Q8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0Q8"/>
    <dbReference type="STRING" id="1220162.K1W0Q8"/>
    <dbReference type="eggNOG" id="ENOG502S03S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853070_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0Q8"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="326" mass="35618" checksum="E2861470F8C270EE" modified="2012-11-28" version="1">MDAPKVTKYDSSTIDNPDRARELVKIIADQEQSLRFDKFDYDVAWKIGTTIREGFLESKFAKEGSGVVIAIELFNDHSLFRCTVGNAPAVGPDNWLWVRGKLAVVRRFGISSLRKGRELASKSKKPEQAGLAFPEYACHGGAFPIWIKVSFLLGWELTSRESRLDRSARSVFLVCRSCTTTSLSYQRPATDGNPGTCSALITHPPANIDPPQTAHPRVTPITQRLDFLLPQDHASLGASGTPITPSNVITALGDLASLLADGRQRHRPAPRAEAQPWWWYGGETWHTTSQHAELPSCSGTVASSSSDTASTRSRPACTASVTGIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1W170</accession>
    <name>K1W170_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">A1Q2_02963</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="23">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W170">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W170"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_1"/>
    <dbReference type="InParanoid" id="K1W170"/>
    <dbReference type="OMA" id="WDGPAAM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 23" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 23" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="25">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="937"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2119"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="2134"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="1178"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="1184"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="1189"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EKD02733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2175" mass="237475" checksum="15E833341C0D4A6F" modified="2012-11-28" version="1">MTHRGATGADARDGDGAGVMTGIPHEFFVREAPHSFEAKIPAEGTYAVGNVFLDPQDWEAQQKVFEEVASKLGLRTLGWRHVPTDNSILGPAAKSKEPRIMQPFVVLRSHYGDGLESADGEFDEQYFQRQLYVLRKQASHRNDKFYICSLTPSNIVYKGQLSPVQVYNYFHDLNHALYSSHFALVHSRFSTNTFPSWDRAQPMRWAAHNGEINTVRGNKNWMRAREGHLKSEKFGNELELLYPIVEEGGSDSAAFDNVLELLVVNGVLTLPEAVMMMVPEAWQNNDLMEPEKKGFYAWAGSMMEPWDGPALFTFSDGRFCGANLDRNGLRPCRYIVTRDDIMICASETGVLDGSPLSRTGTTVVSGDDDVVGLGLRDARSNNANAHLRDELDRDAGAGVGTLEVVDELLQVLDRVNVVVRRGRNERHTRRRVTRATNRGRDLVAWELTALSGLGALGHLDLELVRVGEVVGGNAEAARGDLLDGRAARVPLGLQLHRVAVGSTLLPLSGTGDGERALGVLTTLACVRFAAETVHGDRERGVRLHRDGAVRHGAGDTAAHNLVPRLDLVDGHALRLVVVKVEHAAERCGLDRLSPILTIEEMNAIKSIQTSTSDWNAKVIDITFDKGEGLPGYHAALERVRQQALEAVNEGYKIVILSDRLTGPNRVPLSALLATGGVHHHLVKQKKRSDIAIMVDTAEAREVHHMCVLVGYGADAVCPWLMMEMIHKIEREGMAKDDQTAETLIDNYRKAINEGMLKVLSKMGVSTLASYKGAQLFEALGIHKEVVDECFVGTASRVQGATFDLLAMDAFEYHERAWPTRAISRIPGLPESGEYHYRNGSEKRINEPASVASLQDAVRQKNQAAYDSYSKNSHEAIKAATLRGMLDFDYDKAQSVPIDQVEPWNEIVRRCVTGAMSYGSISMEAHTTLAIAMNRLGGKSNTGEGGEDAERSLPIPGPGQGQEGTPYRHSMELQPEWDSRRSSIKQVASGRFGVTSNYLADSDELQIKMAQGAKPGEGGELPGHKVSASIGRTRHSTPGVTLVSPPPHHDIYSIEDLKQLIYDLKCANPRARVSVKLVSEVGVGVVASGVSKAKADHIVISGHDGGTGAAKWTSIKYAGLPWELGVAETHQTLVLNDLRGRVTVQTDGQIRTGRDIAIATLLGAEEWGFATTPLIAMGCIMMKACHKNTCPVGIATQDPELRAKFAGQPEQVINFFYYVIEELRAIMAKLGIRTINEMVGRADLLKVDESLRTPKTAHLDLSPILTPAKPPREGVATYRVRPQDHRLYVRLDNKFIDEAEPALSKGLPVEIDCDVVNTDRALGATLSYHVSKRYGEAGLPRDTIRINMKGSAGQSMGAFLAPGVTIELEGDANDYVGKGLSGGRIIAYPSKKAQFKAEENIIIGNVCFFGATSGQAFISGIAAERFAVRNSGATLVVEGTGDHGCEYMTGGRVVVLGLTGRNFAAGMSGGIAYVLDMSHSFAPKVNMGTVELGKVSDPHEIAELRSLIEEHRHYTGSEIADRVLRNFHHFLPMFVRIMPLDYKRVLEEQAAAALEEKKKQSHIDLIPSTTASQVDLAAPGVDPVLPGAMARLRLNKPSETDTPHTTPNSPRLEPAVLDMEDAMLDEDQYKARASKLDKVRGFMKYKRLNEAYRPPRKRVKDWKEISNRLSEAELKQQTARCMDCGLPFCSATNAGTGGGCPISNVIPKFNTLVFEGKWKEAWERLMLTNNFPEFTGRVCPAPCESSCVLGINELPVGIKSVEAAIIDKAWEMGWMVPNPPPQRTGKKVAIIGSGPAGLSAADQLNKAGHLVTVYERASSPGGLLLWGIPAMKLDKAVVKRRLDLMEAEGVKFVNGVEVGKDLDGKELQAQFDAVIVATGATWPRDMKIPGREADDIHFAMTYLHKNTKSLLESNFEDEDYISAKGKDVIVIGGGDTAMRHGAKSIKNFELLPEPPATRAPNNPWPQYARIKRSDYGHLEVAAHTQKDPREYCITTKSFDLDENGKLKGLTTKRVEWTQVSGQWRMEEIPGSEEQWPCQKVFLALGFLGSERSLSENMGFKLDARTNVVTKGFATTVPGVFACGDARRGQSLIVWGIADGRACAEEVDAFLMGSTRLPHQGGIPGRSWVPPRASKTPGQANGNASDSDSGLEPEVVSKSDAESDGFSAEAEGEAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W185</accession>
    <name>K1W185_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W185"/>
    <dbReference type="eggNOG" id="ENOG502S103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389890_0_0_1"/>
    <dbReference type="InParanoid" id="K1W185"/>
    <dbReference type="OMA" id="HAGLWRM"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="86"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="652" mass="72522" checksum="AF3B494BADD376D7" modified="2012-11-28" version="1">MQPCSTASLGSPGCLKLHDHTRTPSPSHALAIPKLPLAEYTDIQRNRFDIEAAHNKLLDALAARLNRGLHGSIPPPPTPLWTLLPYAGRKACVDHLGHPVVVLSLRDVARDDTGSLDELKDWTWWGLELVRRALKEYWVDGRRGTGAEGAVLIIDAANAGYRNLEVELLPTLFNVARDSYPGEFESVYVVNAGWSHRAMWNNILKRLLPRSAVEKITFLESRHDTEAVFDLDTLPKALGGDGPPVDHETMLHHLSISRSRPSSRVNSRAPSRKGSRAPSREPPKSRNSLSRATSATSMADVFFTAPASPANLSRAGSRAPSRKSSHLMLSQLNHKLAMTKHEEEEAATVGGDPSRAFDYMRGEAPKSPLPDEPAVQSPLHRIKSLSDFHLYLSPSRLAHRDLLSDSEDEGRDQVHIRPPIQRRRSLQPAFMEGSTLAARRAAARNAQLSTAQQNYTYSLLEHHAQGLERYNPDVLTLPALLLPEEEPPATTPTTPIEEAEPVPAVGHFAEENPWFGYPVVRTSDGQVRPRYGRNRKRDLIKTLLWLFVIRLQSWRDALERAIARMLGLKSLGYPYFERKRVKAANPTAGLLRTAQEKRASSSRAVVRATSRDWIWMLIGFLLMRGSWAPLLANPLEAVGLTGLKDWLGVTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2H5</accession>
    <name>K1W2H5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2H5"/>
    <dbReference type="HOGENOM" id="CLU_1344084_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2H5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852230" description="MARVEL domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23046" checksum="3320A47125611220" modified="2012-11-28" version="1">MFWSFAGLVWLLVIAFSSPISAQRSLRSETRTLAVFTWLGLALMIWQLLGFFIPVGILAAKVPVLYVTTFMALLFVWGWLLWLALCIAWVYESRWAKKNAHGQTQQSMQTLVSQEAALDFNAYAGNKDWDSENERPSYNAYRTPYDTTLGTSETEITPFQQAGPSISTDAKGRPIQDHEASIAPAHPMISPTETKGRYMRVHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4Y4</accession>
    <name>K1W4Y4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">L-ornithine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4Y4"/>
    <dbReference type="STRING" id="1220162.K1W4Y4"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="InParanoid" id="K1W4Y4"/>
    <dbReference type="OMA" id="FGSMAET"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="108"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="248"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37155" checksum="1B2F2138F0EF754C" modified="2012-11-28" version="1">MGSDDNGAVRDLVFGSMAGMAAKLFEHPFGPPAEPADRPTAVVHGSAGLLQEDAEERGLPWPVCSDQQGLSAPVVGAAMENATLFFVYNRCQAGIVSLRPEAQRDAPLTIPELALSGAGAGAVTSYVLTPIELIKCRMQVQQISHPAGDVIVKTGLEAPASPASQVVLPASMTQSNAPKGPLALIADTVRQNGIRGLWLGQTGTLLRETGGGAAWFGMYELLAKYFISRRQKRAAPDVTITKADLSPWELMAAGAGGGICYNVSLFPADSVKSTIQTYAELNPNKPVPGFVETARNIYKSRGIRGLYAGCALTCMRSGPSSAMIFALFETLTTHLGWIFDKKPATPAEPALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6I7</accession>
    <name>K1W6I7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="1">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6I7"/>
    <dbReference type="STRING" id="1220162.K1W6I7"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="K1W6I7"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="320" mass="35842" checksum="14BC03494128D46A" modified="2012-11-28" version="1">MRGEPKDGKKIGEGTFANVYKAVEKSTGRKVAIKKIKVGEMKDGLDMTALREVKFLQELHHPNIIGCEAEREPRARVPRHGSRGRDPGQEPDLPNLRHEVVDGHESARTRPNNLLIASNGELKIADFGLAREFGDAGGKMTSQVITRWYRPPELLWGARYYSTAVDMWSIGTILVELVLRVPFLAGDSDIDQLKKTFHAMGTPTDEDWPSLPDYTEVAQFPKNPWWNLVASLGKDGQDLCRELLKYDPKQRISAKAALTHRWFTSAPRPTPPVLLPKPLAELKPRDIGPIETKPHPESGTKRKASPAQEAVRNVARKLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7B5</accession>
    <name>K1W7B5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7B5"/>
    <dbReference type="STRING" id="1220162.K1W7B5"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526965_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7B5"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="2">
        <location>
            <begin position="411"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="517" mass="55552" checksum="C64F373B832C59D0" modified="2012-11-28" version="1">MSARPSPAGSPAPRPPPINLEGIYANIPILINRVRNGQLNANQIPPIILTLSIPPAQRHPKHRTNAQLRNLLANHAKDIIVFHARLGKPNPLLSLPDVLNPTKKVGNNEAITTEALFLQSVAAGMNQAKNIRADPAFVTAMAAKQAALRNQQVRPPAPAAQPAAPAAQQQQAAAAQAAATTAGTASPAAAPGTASPANASPASTPAATPAATPTAAPAAPSPLGASMLHGPCGSHNPNSPCMVQQPDGSKRCRFRYPRPFQEFTQFDEDSYPTYRRRENGRVYSDPAKANGFAYTNRWVVPHNKFLTAKYNAHINVEIASTLTAVKYLFKRFETEPGLKQRFLSSYTFYQRRSQANAARAAQPASGQASPTTSAPPTPTAQPAPAPPPPAPVRQPSPPKVIPPEPEGPRRKRKLREYMKETAPHLQLELGMDDVFGEILDSLVDTATKDAIRLAAHRKSSRVELKDMALVLENYHDLVVDGFNVQVPKKVHVEPERKGRGVVMRRGAAATAGKKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W903</accession>
    <name>K1W903_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W903"/>
    <dbReference type="STRING" id="1220162.K1W903"/>
    <dbReference type="eggNOG" id="ENOG502SW00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393889_0_0_1"/>
    <dbReference type="InParanoid" id="K1W903"/>
    <dbReference type="OrthoDB" id="2563047at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854274" evidence="7">
        <location>
            <begin position="25"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="639" mass="68444" checksum="C25313744A1D7D74" modified="2012-11-28" version="1">MLSSGLAARLLLLVGQGWMTTVAAQTINVPEQQDVTLSTPTQPLNVSIPNNSPLLTYRPNVTSGTPDLAWNITWSDSPWPKWQEGALGTGRSAHVTYNKTAYVYFSFVGTQIHYNGKCPGCNLTLFIDKDSHFGLTNDLGEEGGIVASSPAMPFGLHTASLAIVNGTMELSNIIYTTELPTYNDVANETETAEVVGTVANANGVEANNNDIQSSEAGGRVWETKQTLGLENVTSTPYPRIWTDSINGYAYFSTPTGASMVTLYGSMDYDHGPYTIEITPTPPGQVRGALRYDGYSPWATKDAVLFSTILDPKRQYTVRMVNMDAGKKFDFSHAAFYVTNTTDPNPGGSGGGASDNSNSVGKGGGGLSGGAIAGIVVGSVVGGALLILLAWFLFRHRSGRNRAVLDDIDDIHDARGAADKAEISPFIMPGVSAEPKEGTTAANAQQRQAPGALNASDESVAYIAEEDAGPAPGYERERVQRVPPSYDPRWSEQVPVFDEPEHDLQGSPEEYDGDDYLQANAAGAPPSSGRLSSDGSHSQALSDEKRRKSSTPTAASQRRQSSTLTTSSMPSEKRRHSSRASDMSDRRTSDTPSTIRRSRSTAKPPLVCGCSGSLAFEPALISDTPNQRHIRRNNGWMPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBF9</accession>
    <name>K1WBF9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBF9"/>
    <dbReference type="STRING" id="1220162.K1WBF9"/>
    <dbReference type="eggNOG" id="ENOG502S11B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839883_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBF9"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="4">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="331" mass="35423" checksum="C7593F3165457B3A" modified="2012-11-28" version="1">MPPHNQTSLVPSDQQQCAETVLGSRSARATHTAHLLKALGLPHAMASGRVTLRQEADGHGKREATSGAIYLLGFPALVLSPSFSYHPVVTPASPPSSPSLPLPAPCSEPPPPKTGSIAPIKMTADLINGHPVPVPSLKNGDVASQLPREAPQAWSKPVGNAKAYSPDHPGRFHVVFQESAQDGVEAYSSKLVADRDYAPGEQLAPLKNISIAPVKAYSSVQFGPGEHDHFELNSDLLFMNHSCAPTAEMRLYPGSPSRWEVTVGPKGLKAGDDITFFYPSTEWDMAQGFDCSCGAEQCLGQIRGAKYLTLEQLEDRGVVNEHIRALKAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBI1</accession>
    <name>K1WBI1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBI1"/>
    <dbReference type="STRING" id="1220162.K1WBI1"/>
    <dbReference type="eggNOG" id="ENOG502RV6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578951_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBI1"/>
    <dbReference type="OrthoDB" id="2587819at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="472" mass="52226" checksum="A27DC0B6472E8A6F" modified="2012-11-28" version="1">MRKPTLPRLTFGSLRKRTPSVLDMPESEYNPVTHLPDRMQIGKYLVKPLVSVQDVRLPESSAVAVSAGGRAAVNRAGGAFYEALHISPLTSVIDHLDLLHAFHDLSHKDGENSNSHRVFDQAAMQYEQWAQNVLPFQLQHRADRAGSRVCASAPMSRSNTSEGTDASPLILDPSPHSPTSPTYIPAGVMTDVCPSPTSYEPTSFSTPGSPASPGTPSSGSSGPTPTVSPQRAPFGRGASHVGHPHRQSTSDGYKELTAEELPPLSVLMCWHAHLLNPPQFAADTNRGTYAALKSVKFPLHAAAEAYRKHALPQRLPHIPESGKLRVIPSISGWTVADISAAVQRQSKIIDSVSALGWFRTDFSHNIAPIQRAIVRYHAWLDLVAHVGNHAHLVPDIDIELVWRTHELKGERYRKETEKLFGEPFDERISRMDTVGIKRTAHLWKERFNKEYLLHPPKNHHAPNPVRRTTMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC12</accession>
    <name>K1WC12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC12"/>
    <dbReference type="STRING" id="1220162.K1WC12"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="K1WC12"/>
    <dbReference type="OMA" id="WATYLFY"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="553" mass="60923" checksum="C77C1F4F748244C6" modified="2012-11-28" version="1">MPAPTAVNATGLRGHSLLYSVSVFLSIGVWLFGVRLRVRGRDVLTTKALSRAPTSKRSPTAGEIGNMVAILEIGAFITSLCAAYLADKYGRRMTMRIGATLFSIGGVFQTYCAGYTSMVIGRFISGCGVGMLSMIVPIYQAEISPADHRGFLGALEFTGNIVGYSSSVWIDYACSYIQSDWSWRLPLSIQVLGGVILGLGSFVCPESPRYLIDTDQDAMGLQVISDFQGRDIDDPKVQVEYNEIREGVIADRAVGDRSYKALWTRYRSRVLIAMSSQLFAQLNGINVISYYAPLVFEQAGWIGRDAILMTGINSLFYVASSIPPWWLTDAAGRRPILLFGALAMAIALTATGYWIYIDQAITPNAVVVCVVVYNFAFGMSWGPIPWLYPPEIMPLPFRAKGVSLSTATNWLSNYWVGVTTPVFQELIGWRLYIMHAFFCVVSFILVYFLYPETRGVPLEEMDKLFGDEVVEVTETETEDEGFSESETSTLVGHRRPGSILPISRTSTRSASPSPARMGNSLFGRVQDMISGGRKTRRSSLGHYRAIDDGDAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE89</accession>
    <name>K1WE89_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE89"/>
    <dbReference type="HOGENOM" id="CLU_055175_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE89"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="414" mass="47115" checksum="6675940B3DDE768F" modified="2012-11-28" version="1">MSVNDRLGRLPVEVWQMAFEHLSQTDLFNLRSVNSALGAIASPFLYRYGLLTKLGLHFPGAPHPYPFTDLPELGHIALRKSDLDRIVHNLRRLEIPTHKSKSCSTVFKGVWPDGLRLNADVLSLEVEQIPEAALRPRERPVFPECFVHTEYNESLGSAMDDHGASNSEVAVDTTCLRACSFLDEPDLWSARVRKVVIRGAPLSWKSQQRPHQVPGGRWATEYVLVVDSAKDWISWIGDVVCMCPEYHRLFGPTKNPIAGFSPFPHDSTSLKRLTIIFWTESPESPWLPPCGHFTKEEHWTSRDVCNSYTEIWDAIVATVRRVPSLQQICLVNTGAMSEQPSAGVKRRARKPYKLFDKTKIADELQTRLQKAYPKNRGLEQPELSFQTVNEWAEAEDWEDVFNVKEIAPFLERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFT2</accession>
    <name>K1WFT2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFT2"/>
    <dbReference type="STRING" id="1220162.K1WFT2"/>
    <dbReference type="eggNOG" id="ENOG502RBB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307369_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFT2"/>
    <dbReference type="OMA" id="TIAREEH"/>
    <dbReference type="OrthoDB" id="2564297at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="966" mass="98835" checksum="7F9F8E9CBB1E50C9" modified="2012-11-28" version="1">MLTDLLKDIKRELALTFDPPPLWATQLEQCIPSESSSSRPESPAGPPKRIVSGSLKDRIAKFNNAGSSPLLPNNDGSHPHSSTHTSYARGGLIGNRLPSLDPKSAGIVGSPGFRRVSEGKGIIGNRIPSSGASVSSAGSAPGSVAGSRVPGASGRSVRSASPAGSATSSVASASASAASGTLDSASVGTSLSSSPATSPGGGFMPPQLLVSTLPDGHEPGTMTPSSTRAEAGEDAISMPSTPVPTASSELPPPDYDLVPGNLKLAAGDAKAGDARSVSSAMSVSSSLVSQYDPASEEGREEGERPTNLKDVSEVSTPTGTPRQALRQLDNDSVAGSSRGAPSAPPSDTGDVADLQDKLDALNVGSAAAAGSKDESAAAQEEKDTPSADSLTPATVDAGSPPPLAEQITPNATADNASKDTSTTSVPSAEKSSAADSQAEALEDLAKRADAAADKLKSEAEGKSSATPGKAANDIETIKDDDTAKTVDRDATPEAPKVAISPAPEKEEDQAPGPTEAIGRRSEDTIMPSASLGNLSTSPSQDDVASTPLATPKDKDSSDTPSVIDLSSSPKLTSADRDSTPVPRDSTTSQSVLDQNSDLVSMIAAPTERPFSDDLSQSQIDNFEDEMSNRSSMPPARASSELEFRYEDLHERFGPDGAKTNPNTNSSHSFTPAAAGGAALAAAAATSDFRGSSSKTEQSNNPLGNVAASAVDENGFPTVPATELKTKSPMQVHIEPSPFGPISDDDVPEEKPEPTKPARPESGTLGSGLTAPVLTFETVKEPTTDRRTPDFPDAPNNTLPNTPGVVTPVRSSTPTANAAASTISPKAFPKVPDEEHPYVGVHISPHAKGTASQLNPKTPFPSAPDGGTPRSEAASARTPSLHGSPSKGSSDGSTRSLGVAPRGPKRLSYRPPELDDEDPGDFEGGGWAVVTKWEPWRGSPPSDRPSRQNSLGHGLREDVPPPVPPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIF4</accession>
    <name>K1WIF4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIF4"/>
    <dbReference type="STRING" id="1220162.K1WIF4"/>
    <dbReference type="HOGENOM" id="CLU_1653382_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIF4"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="160" mass="15804" checksum="4A11253CC5CD1548" modified="2012-11-28" version="1">MFEKFNITDLDAAGGGGEYTVQVGFGWTNGVVLWAAERFGQYLRTPTCPLILITQNNGTSSGNSTGPPPNSTPGGGGAGGAQPSGQRSTAILPMSSSLPPANGNTVTTTPAQSPQGGNAAQPTTSAAAPAGNNGGGNGGGTSASAPTARSFQFVGRRIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIZ4</accession>
    <name>K1WIZ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calmodulin-dependent protein kinase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIZ4"/>
    <dbReference type="STRING" id="1220162.K1WIZ4"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="K1WIZ4"/>
    <dbReference type="OMA" id="WKAADPP"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="448" mass="48700" checksum="F1D00698E622E191" modified="2012-11-28" version="1">MGITSDLRDALLSQPKSFKKKKEYSLEELLGRGGFGKVVRATWRPPGGEEKEVALKIVPKKLVKDPSTIMDEINVLKDLDNPHIVHVWDHFESRDKYYIAFELAIGGELFDRITERGRFTEKDAGDCIRQVLEATAYLHAHQIVHRDLKPENILFKTRDPVSPIVIADFGIAKHLEPDEEITSMAGSFGYAAPEVLLGKPHSYPVDLWSTGVIAYTLLCGYSPFRSDDKAELIRETTRGKVTFHDRFWKHVSEPAKDFIRKLLVVDPKQRLTAAQALQHPWIVASRGAMKEEDAARSAGYDLSSNIRENFNPRKKWSDALNVIMASNALKAAGRKKEEPLDSDSSSEEGYATADSEASPASAPATSAGAAAAGAAPAVPAAAAVQASAQAAQADVRTPSPAQSTPRTPQTPATPKPSTPGVQSERAPSRSSSGFGLAGLVNSLKAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJZ3</accession>
    <name>K1WJZ3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJZ3"/>
    <dbReference type="FunCoup" id="K1WJZ3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WJZ3"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351670_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJZ3"/>
    <dbReference type="OMA" id="TINTFSH"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="800" mass="88789" checksum="47A29ED55E91AF16" modified="2012-11-28" version="1">MFLRPPLRPTDAQPNYHCSTCGRSFQRLDLLQRHERRNICDDERYPKRLKSRAHQTTATAGAAQLGKSQNGTPSQPQSQPQSQPQSRMGSSKPPPTSHRPQSQHGQQTQANGTPDSVGQSTVSNGPLVNRALASASTSQTDSPGDFSNHVFPVLDLLDVSSGMAGQNTGAQNSALGVDGQNGPTSTSVTPVNGLPNMNDLSTSGHFIDIDPNTVASAPICFEAIGYDFGYGAGPPHPWEALLNDALAPVFWDERTIHDAQPWEQLLQQSQTRTQESAERALQNDVNVPLLQRLLASYPDLNMTVQDLNESIQLYWSKVAPTFPFIHRGTFNTELATSELLVMMAVAGAVHRKDVPRRDDRALTRRVRSRLVEDRFGLEVELATLQAYTLCHIYDVWYGDTETLFTAQCMWPVVVAHSRMQGIGAIGAQTPSDHQHHGSDAWQNWAKDEERRRAAYCILYLDTQIGTFWSQHPSRQLSIFAHNINLPAPRSQWEAMSATEWLRAREADPNSRHARHHYSLTHGEFNHHQGAHHQPGDGGYSPAILQALSVDNTQGGQQAFKVDVDNSFSVMLILVGLSAIAWDSRTRGGMGIKFRDGTKHWRNIILKAVVALRASYEMAINGLPPCNETRDIRDWIAISIIQILSDLPMLQVAAGSSTVCGTAIGPKQYADARRRLKLWVATGDAWTCLWQSARFLRETLHAEWGLYTPWAVFLTTLVVWGCGQAIAREDEELPPPSENPEQGAREMLETIFNSPNRVNKLDRGVLDLVVVAASRLENNGSQHTIDNDCAQLLWRLAKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKY7</accession>
    <name>K1WKY7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000305">
        <property type="protein sequence ID" value="EKD01929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKY7"/>
    <dbReference type="HOGENOM" id="CLU_1046575_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKY7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="28068" checksum="6F3E233EFBA555C8" modified="2012-11-28" version="1">MPLPPRSVRVSGYHVRRSSASPSLVYVDDVRAEMALLPHSAPTASASTSGVKLAQIVRRASPASSRPSTPMREREIREVREVPLATLIEAHSGKGRPPRSGTAAGLGYDVVPRPEVVALDDKDASTDTPRVPSMPTPSEARGGRKPSPSRSPRAQRSPRLVPTTGSTTGSNTGSNTGSNTGTTPPLDSASASCSAGTSVTSTISGSPRRFWSWGEPVTPRLEATEDEEWEYVDVEDGMVGELELEVVKDVASGLGQGLAYAEVVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WL54</accession>
    <name>K1WL54_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WL54"/>
    <dbReference type="HOGENOM" id="CLU_785705_0_0_1"/>
    <dbReference type="InParanoid" id="K1WL54"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="353" mass="36563" checksum="9DC8A2088B371C58" modified="2012-11-28" version="1">MTLLGTLGPGHGGPGLLGERDLCVPAPNKALEHVSARVDVLGELLGKDRAGVLALVEAARKVLKHATAEVEREARECGVLVLVELGAAREVLGEAGGVARQVLLEQLGRRRLSERVLEAGAGAGAVLAPVRAEVAVSDRPEPDGVLVRVLEEALELLDQGDARVVDRRTGRDTAATAAAGRNDRVGSARRDVVVGDEAAVGRLVPDRVAANRLAARVARELDLGALRVVLDDLAGRAGAGAAVQRLLHGVGAGARGERGDGEGEGSDSGEEHWGQLGRGADSLFVQRKSMSVSSSSRPSYIPFSSPSNHRRQSPRPAPPHALRNNVHPALVLSRASGASLIRTPAAAAGTFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPG3</accession>
    <name>K1WPG3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPG3"/>
    <dbReference type="HOGENOM" id="CLU_804566_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPG3"/>
    <dbReference type="OrthoDB" id="2597004at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35318" checksum="90183608F4DFC922" modified="2012-11-28" version="1">MSRCELQQAIKIPHASFPHIIDTIVAHSDYKTLLAFRATSSSLKTVADMTLCNHDSAVRLTLEGKPGEDNVVFRNGLGALPFGHREWPSVLKRSKEVQIDGHCLSNTVPTLVIEPGTSLDEGTRQFYSHLLSKHRRYDQLLLLEAGLDQLPRSTAVTVAHDDQHPPLASLPPVDQLTLLADPFCDCSRVESLSPYEHWASRITLIICSSGNNTGANLDERPDCGLISAIFQPSLTHLVISAESCTHIRYLPRALRRGRRKVNKKLQVEFRFRIMPNDVARHDILQRFSLRYGPMLDRMRIVHDPTAGRVWPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPH7</accession>
    <name>K1WPH7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPH7"/>
    <dbReference type="FunCoup" id="K1WPH7">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WPH7"/>
    <dbReference type="eggNOG" id="KOG4002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065417_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPH7"/>
    <dbReference type="OMA" id="NVQYLIM"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="31419" checksum="D310317B7E75A441" modified="2012-11-28" version="1">MIVDPHYLWAFGHAIVLVNSAYVMLQTLLFRTPVRAYRMVYVGALLSYAIVVLKSLGKPRGVNWLRRAFVDENFQYGLLALYWLISKPINITILPFATFSLFHCATFLRTNILPKFYASARCASKLTSSKTSGPNAQPNWAESLGRRIQSWVKGHYDSAMNFVSYAELVIFARVLLGGLTFQNSFVAPIFFAHFLRLRYHQSTFTKNAIDGITGRIDGVVAKQGAGVQNAWGTAKRVIRTWGGGNLVGNSNRAQARPAAQGAGAAAAGGAQARATGVNTGAAGTANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPX4</accession>
    <name>K1WPX4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPX4"/>
    <dbReference type="HOGENOM" id="CLU_009687_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPX4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="738" mass="84057" checksum="DBEEC28F209B3F49" modified="2012-11-28" version="1">MIDISADDLGQFERCWARSIFYDHSANCRNPTKGPRLDHLPGKAPSARVLYPAHLPDSSFLARLQCKQPSTIERILSLPDYNHIIGGLERDFTSRWVSHYRLRKNFHRLTSLFVIKEAFEGHGMDFWTDDLDCDETKWYFKGDRHLKQSLLARTVFSLRLISVGSEVPFAQTPFSQLYRGIYDRDYRQWARTHLRYRDGPRRPDVLLVARSRLQSTSVIAECPVEMASWPFRQPCDFFRVYDEELWNSMTTQERIDACELVLRDRVDKRVHNEARRRWLQLGETPEGLFQSVKPEEAERVVYEAGLPHLRQAGRKAFAAVVAHLLNLFEMCGSVYGCIVIDRRFARMYVLSSGRIAVEFSTAGELVDLGTPVQGRGGLPYSRIMHMDLHAALPLRFTGDELSPGQPRTFWFDKLGDQVTSCDVEDEEDATPSEKFDRCQTSADLGCIQTYIDFMAAGVVRLGAVNAHVPISEKLPAPVQDSLDADILACIVQKGLPMELAIKIREEARRPYNLSAYLDFSAEEQQGRPESKGLWRRLVKHWRDGHDPRWDYYPENTSSEGGASTAGEDQSDGSEAASDFDRNMTPSGDAGDNVDDVVDERGGGALEADRTGSEADDEIESDREESDDGSSDSRSLYSERTRQWLLETGSDADNTVAHETDWRTFDPWDDTDGDVLGYSSWSAENDWFEANQNLENDTCFVLSIAERVLQELCHIVPVTKEEMDELVQTQYALDLERYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRA4</accession>
    <name>K1WRA4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRA4"/>
    <dbReference type="FunCoup" id="K1WRA4">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRA4"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023894_1_0_1"/>
    <dbReference type="InParanoid" id="K1WRA4"/>
    <dbReference type="OMA" id="SLDQHWA"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Prp19 coiled-coil region" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="422" mass="45350" checksum="58C5F01DD4618A1E" modified="2012-11-28" version="1">MLESLEIKKAFQNSRAELANALYREDAATRVIARLIKERDEAREALSSIQASVGLAPSAPAAAPAQDDVEMESGALPKEVEQVLEETNASLSSVRKKRKPAPGYANAEAVKTYVQVKEIGSMHGTKPPGVSALDLSKDGKTIVTGGMDKVVQVFDIENEKSIATLKGHTKPVTHVEFREQEGLNRMAVSTAADKTVRFWGEDGGSWSAKGHISAHKGDVTGLAIHPSGLYASTGSTDSTWSMHDIASVKTIATYKPVGGEEGSFSYTSLDIHPDGILHGLGTKDGHIRVWDARQNNVLAGSLLVPGGKEITTLSFSENGYYLATGSSADSLVSVFDLRKLKVLSSWNLPSENSVHEVRFDPSAQFLSVAGTDLRVYANKSWDELLKFDDNNGILTAARFGNLGSEIVLSGLDRTVRVLGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSB7</accession>
    <name>K1WSB7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01897</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSB7"/>
    <dbReference type="FunCoup" id="K1WSB7">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSB7"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_2_1"/>
    <dbReference type="InParanoid" id="K1WSB7"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="79"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="354"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD03884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="745" mass="84460" checksum="578B2A0CEFEEBC8B" modified="2012-11-28" version="1">MSAPAAPAGEVKEVKPQAPVAAPADQVKQQNKKEKKEKKEKKGGISELSPPPEYFEERIKIFDEYMAKYQDFVAKQPREPITVTLPDGKQIQGTAWETTPLEIAKGISSSLADRTVIAKVNNQQLWDLTRPLEGSCNLALLDFDSPEGDYEARQVFWHSSAHVMGEACERSFEGCCLGYGPPLPEGGFFYDMSLGNDKTIGQDDYKQIEEISKKAVKEKQPFQRLELPKEVLLQMFKYNKYKQHYINEKVPDGTSSTVYRCGPLIDLCLGPHVPHTGRIKSLAVTKNSSSYFLGDAKNDSFQRVYGMSFPDSKQMTEWKKLQEEAAKRDHRKIAKDQELFFFSDLSPGSPFMLPHGMRIYNTLMKFIREEYHKRGFVEVGSPNMFNSKLWETSGHWQHYAKDMFTLKVEEDTFALKPMNCPGHCVIFDSRDRSYKELPLRLAEFGVLHRNEASGALSGMTRVRRFVQDDAHIFCTVDQIEEELYSAIDFLDAVYKPFGFEYKVGLSTRNPEKWMGDLAVWDKAEAALKGVLEAKVPGKWHINEADAAFYGPKLDFDLTDALGRKWQCGTIQLDFQLPERFNLQYRGAEASKADQEVAPGELQPGYHRPVMIHRAILGSLERFLAIITENCAGKWPFWLNPRQVVVIPVAAPFKQYSEEVAKAFKDADIHADVDLTDNTLNKKIRNAQIAQASMIIVVGEEEQKAHAVNIRNRDAADPGRGEVIPLDVAVKKLVELRDSRERIVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVS1</accession>
    <name>K1WVS1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVS1"/>
    <dbReference type="HOGENOM" id="CLU_1103423_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVS1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="28922" checksum="4B247900167EAAAA" modified="2012-11-28" version="1">MAIDKYSDHFRTDPASLPRPPTTFPRTQWLELVPSPPFHESHTATQVAWSGQQASWCWSRCKGNAAPQPNHLTAPAVPDVVDETCFKLAVFDKVFELMMHYKYQQSNMIPKHAFTWRQYVREVEGLMSTVYKWLPPNSPPPPSLPRIAPFLRSALHSWSDIINISNRPSDRDLFAPRGVVPSPSTAPLEELCEEDFGRFASKYYTVRSIMFCTGANDEIVRRQYLWEGETLPSELEPVLMRPSWELKGMPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWF0</accession>
    <name>K1WWF0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_00613</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWF0"/>
    <dbReference type="FunCoup" id="K1WWF0">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WWF0"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_1_0_1"/>
    <dbReference type="InParanoid" id="K1WWF0"/>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="15">
        <location>
            <begin position="35"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD05069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="444" mass="48185" checksum="D521A8D539DCC367" modified="2012-11-28" version="1">MSSILRPAARALGRRGLATPAAHPSLMTPVLPAKIPAALFLKSGQVYEGQNFGSTNSKWGETVFSTSITSYTDSMTDPSYRGQFLVFTSPMIGNYGVPSNAPRPETPGIPFLESDAVQCAGVIVSDVALKYSHYQAVESLHEWCARYDVPGLTGVDTRAITTLLRDQGTTLGRMAVGAEEIAKGAPAAADYWDPSKDNLIAQISTKQPYTLNPNGTGPRIAVLDFGSKANILRSLVKRGAVVDVLPWDFDFNAVRDNYDGLFLSNGPGDPKSIMPTVERVRKTINEWNKPIFGICMGHQILGLAAGMEAYRMTFGNRGHNQPVLALASSGSIKAGRVYVTSQNHQYALKLTEDFPEGWAPFFINCNDSSVEGIITTPESGKRIWGCQFHPESAGGPLDTIEFFQDFLDACANPNSKIDDVKEDRSVGELRRKDLAAANQPTVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWY5</accession>
    <name>K1WWY5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWY5"/>
    <dbReference type="STRING" id="1220162.K1WWY5"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806948_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWY5"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="165"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="344" mass="38765" checksum="E25DE3DB91B3DF7C" modified="2012-11-28" version="1">MSLLSRSARSALAVRRAAAVPTQAARFESTDASSSSAAKPAADKKSDKKVPAKQPAKKREVSFEDRELERKLNLKERVRKQSELERTTLRPDQQKSYNAPYAVYPKRNPWDINKLPEFKWDEPSSAGFLRIQQIEEMRSLMSKAELDRPALQAQAEAHPFKLPKGQIRVQRTIDLSDPESPLQQKAVVIAPVSALPLEGADALRRFKVLAGPRWTPGWPGRMELEQAAEGVGAEGYVKISEETYATMRMNRKSASDMLERLVAAANDANSPLPKDVQADPRYMLMRAKKRNGGARDRGLTIEALKRTPTAWAASRASRSSGSRPRCRRRRWLSRRSRPRSSRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0M1</accession>
    <name>K1V0M1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">mRNA polyadenylation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0M1"/>
    <dbReference type="STRING" id="1220162.K1V0M1"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2924364_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0M1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DWNN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="61" mass="6923" checksum="48203600E4EDA45D" modified="2012-11-28" version="1">MSTVFYRWGAGRDESRVKFDGTHISVFDLKRQVMLDNNLGNGKDFDLVVAENGEGKLPEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4J6</accession>
    <name>K1V4J6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4J6"/>
    <dbReference type="FunCoup" id="K1V4J6">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V4J6"/>
    <dbReference type="eggNOG" id="KOG3157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_2_1_1"/>
    <dbReference type="InParanoid" id="K1V4J6"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="30031" checksum="8F36CC1806D602E2" modified="2012-11-28" version="1">MDHSLAYTPERGEELKSNLDEVLKEIDEAKPSGSNVSCIRSQLSRPRELADSQPRLVAISKIKPPSDIQALYDAGHRHFGENYIQELAEKAPLLPKDICWHFVGSLQSNKSKMLAAIPNLFVLETLSSEKLAGTLQKALHALPEERTMRVYLQVNTSGEDNKSGLPPLKGTDQGQELAKLALHVVNDCDRLELAGVMTIGSFEHSHAAGENPDFLTLKETKKYLEEILKEAGKERDLEISMGMSADFVEAVKEGSSSVRVGTRIFGARPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4W1</accession>
    <name>K1V4W1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4W1"/>
    <dbReference type="STRING" id="1220162.K1V4W1"/>
    <dbReference type="eggNOG" id="ENOG502S9GI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857934_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4W1"/>
    <dbReference type="OMA" id="NEYAWDE"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="144"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="297" mass="31142" checksum="6DA8DBA178280382" modified="2012-11-28" version="1">MSDWWTQPSTPARQSAFSSPARASSSRARFVSDDPDPNSEAPKFLPTFAASPAAKVALLGVPANLQGSSPGAASPPAPKRSPTARFSSSINESTSSPRGNMTRYRASQADEDGIPTSSLHDDPPARAAPQAPASIPVPPALEPDADTTTLHVFGPPVEFLSTLRAYLESIGPVISYVPGPDGSNWWVVTYGDPLAASYALRRHGEIVNGRWMLGFKIAGPGSTQGLTLVSGVGPAPVNSSAAGNAVELKSASIIRPKPKASEVAKEDYAWEEPEQPSGILGRAAELISVDTVYDRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V606</accession>
    <name>K1V606_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation-like factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V606"/>
    <dbReference type="FunCoup" id="K1V606">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V606"/>
    <dbReference type="eggNOG" id="KOG0073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_12_3_1"/>
    <dbReference type="InParanoid" id="K1V606"/>
    <dbReference type="OMA" id="GMEWIVQ"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="28650" checksum="1019466165CB087C" modified="2012-11-28" version="1">MGNCTLRVKLIPGLLTIIRKNKAKAREMRVLFLGLDNAGKTTILKRLTGGDVREVSPTLGFNITTLVRTIGSTAGAENAAAASAGSSSAPKPVAGAGDTYTLNVWDVGGQRTLRPYWRNYFESTDAVVWVVDSSDTLRLDDCSSELRQLLSEQRLAGCTLLVLANKQDLAGSLSMEQVRDQLHLDGIESHTWRILPCSAITGEGLDGAMDWVTAEVASRLYYGGRSAVNPGVIREEARETRAKDEIATQVETPDQAVDTRAVAMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6H5</accession>
    <name>K1V6H5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6H5"/>
    <dbReference type="STRING" id="1220162.K1V6H5"/>
    <dbReference type="eggNOG" id="KOG4013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050555_3_1_1"/>
    <dbReference type="InParanoid" id="K1V6H5"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="22518" checksum="2E1D445D26EE41DB" modified="2012-11-28" version="1">MIRPRPGSFVYSDNELDVMLADILAAKDEGAYGVVFGCLTQDGEVDTAACERLVQAARPLEVTYHRAFDVTSDWRRACDAVASVPGITRILTSGHARTALEGLEELEQLTTYIRQKGYKLKLLPGSGINPASLDELYHRYGLFNEAHLSSGGAVKPPIDPMLARGHLLGFGTGEMWRLDPNKLAGVRGIVDMINERDEGASYARGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6V1</accession>
    <name>K1V6V1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6V1"/>
    <dbReference type="HOGENOM" id="CLU_077751_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6V1"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="34817" checksum="66F36F120043151E" modified="2012-11-28" version="1">MTTDLVDGNSQQCSGSFQDHPEWQDGDFDLVSSDGWRFKISSDLLFESSCTSESPSTPPSHLFTDPVIERKHVITRYLQLKHKSVGDDAFMRRQAGSLLDRILLTEYTHLIRFLNKWGCDDPMQVSNAMLRLGVSLIGACVNRTLDPLDIFILGAEMDEKNVCATAIAAGCFADRVYDPKTGEYREVSNAMLRLGVSLIGACVNRTLDPLDIFILGAEMDEKNVCATAIAAGCFADRVYDPKTGEYREVIWGVKQLPNRFMQLCAPAYLEAAIRAIREYWKARGTTGDRKLPFDFLQDRFCLGLESPSDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7Q7</accession>
    <name>K1V7Q7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7Q7"/>
    <dbReference type="eggNOG" id="ENOG502SZZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083550_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7Q7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="239" mass="26809" checksum="47D70D5E035C90C5" modified="2012-11-28" version="1">MVTRPLMSLHRRRSHVVITPIMKAHIDHLVLAAPTLDKGVEYVEKLFGVKLPREQGGAHEGKGTHNVVVSLGDDVYLEILALDPNAKERNDPRWTWLDNKPKDFQPTLETWAVRCKDVRAALEETDIKPGKVVEMQRGDMKWLITIADDGSLKPAADGAFPFMIQWENDSPHPVGSKLKDSGLHLKTLQVRSLDYQDIISCLHGIGLHDHRLRVSLGEGPRLVATITTPDGERTLETHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9A3</accession>
    <name>K1V9A3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9A3"/>
    <dbReference type="eggNOG" id="ENOG502SDCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314023_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9A3"/>
    <dbReference type="OrthoDB" id="3366922at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1065" mass="115960" checksum="4227D5D52A554E8B" modified="2012-11-28" version="1">MPPSSDPFDDYDDLDFDPATLKEIEALEKRASSVSATQSKKYHHTVAKPAKPRPAPATKTAPRPINTNPRVSGCGMGWEPGGKHATKYAPPPLVSQRIEEESLPVDVVVDEHGRYSAASQGEVIDQRTRPEIRQMVENAARSAAPPPLPGSQARREAIFSAMAEAGPGPTTANSRQFQRSNSSSAVPSATAKVGSSRTLSRSVSTGSNVFNRPPPSKTALQPALPPITASQSSSQGAAARRVAGELEDERRKREASDAEGEVIDQRTRPEIRQMVENAARSAAPPPLPGSQARREAIFSAMAEAGPGPTTANSRQFQRSNSSSAVPSATAKVGSSRTLSRSVSTGSNVFNRPPPSKTALQPALPPITASQSSSQGAAARRVAGELEDERRKREASDAEVRALRAQIAQLQTTTNNTVWADGPAIDTPEIAALKQQLWTAQGQAATAKRNQETNQQLEAQMRTRELEAKQKLESMRTQAVFSNHNAMASASKARHQSQWSSSQRPGAPTPLRASPLKEKTMRTPAPLTRSVTKAKATSRKRQRTEAPLSPSSTPRKAHQYSSPVVSPVRSQGGHVASDGDVSMDWQPDFGGFDARANVGSTAVILADRDAKTEHHLLSHSAFTPIATYIKDSQPSIFRLMTSEPLQEELVPEWQKLCNGLLALIHNTTLPYDDGFCERLLGTLVRLVEIAVHATFVEQLEEMRHIEFFLTTAKVETVDGWWSAALARLGGDARSSWEEEVADTVAELGEALCLNSNRSQSCLSGHSLLAARSTCSLWRQSVSCLPVHMELTLAGDEFFRALLFPREGFQGGAPVIDRVARFLVSPPPSMSKDQIHRHTVAVLSGLFILARHNADAVVLLAEQSVLVTSLLMLLCRESVSIWGIRSDPVAHDSPHTSTPASSSVPRASSAAIFEPRNTNKGRRRDHATGRRPCAQTARTERVDRPQPHVRLNAGRDSLRRSRHRRRRVGVRLPRAETRTQAEDGPERSQADAVLGTGDRRKLDCSQQQADTPVLAQDLLERVVEGPEGDTVYEVFAEQETQPSPEPEEEEYDEEERVMDAWPGMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9P5</accession>
    <name>K1V9P5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9P5"/>
    <dbReference type="HOGENOM" id="CLU_1579620_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9P5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="169" mass="18358" checksum="446F2ED220577A61" modified="2012-11-28" version="1">MSSTDAPSAACRLSIAAFTAPLSTIPSPSLLIYEKQEADDVPHIDSRGTDDPPTVDQDRYEDRQQDSVQHKRPESSQRSPENKLQPRSHAAVSHPDPAGLGAVAYCMGGEHVSDGGLRSGRAELLHKLSPGPDPSPANDHPTSLRRNSESFVDSRCPRLRRRATSMPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAI3</accession>
    <name>K1VAI3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000327">
        <property type="protein sequence ID" value="EKD01035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAI3"/>
    <dbReference type="eggNOG" id="ENOG502SDZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921930_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAI3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021660">
        <property type="entry name" value="DUF3253"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11625">
        <property type="entry name" value="DUF3253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33013" checksum="E1914E69E8260258" modified="2012-11-28" version="1">MPSPPRTPTGHHITVHGRRWRASDPAIPPKLRQELVNSLMAGRRGVRSDGAKGSVARRKVQDAKVALGERGVEWWIPTDASQDGGVEEGTATKEDEKTDGEGDKGTEDRENKLWWQLPWKRDGLHARIDSTIRSLCRAREHGTVCPSEVSRAVAGDATEDWRELMPLVRERAEGLMRKGQIEICQKGERVEPGEYKGPIRLRVAAGIDEPEGNEEGAEDADDSGDEGEKEGGQGGEDGVNGVNGGDKDARDEETSDEGTTAKGKNKEEPVAQTTRGGKRQHTPDPPEAESDSLPLRSGKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC32</accession>
    <name>K1VC32_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FK506-binding protein</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC32"/>
    <dbReference type="FunCoup" id="K1VC32">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VC32"/>
    <dbReference type="eggNOG" id="KOG0552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022297_3_0_1"/>
    <dbReference type="InParanoid" id="K1VC32"/>
    <dbReference type="OMA" id="TLVKIHY"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="314"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="400" mass="43974" checksum="E9E6F38843AFDB6F" modified="2012-11-28" version="1">MSRLLAQEHPANIQSLTLIPGEPIPLYVNRDFQITNAALAEDLLSETGRSVVKVTHNPISQSAFEEDSEFDSDEDDESFEGPEGDDDDEESEDSEEQEGEDDDEEDDDEDMEDDSDDEDDLEETSVLCSLTAGKCEQAVLNLTFVEGEVVIFEVTGENAVHLMGNYVNQFPADDYSDSDSEYESDDYDDLSLDDEDEFDVEEFDEEVEVAPKGKIELIEPESKPSKQDKKRKAEEEAPAAEEQELSKSQKKKLAKKAKLEEAAAANVKKEKEAAPKKESKKLSSPVSQLTPQTLPSGLIIEDVKQGNGPVAKPGKRLGMRYVGKLENGKQFDANTSGKPFSFVLGRGEVIAGWDQGLAGMAVGGERRLTIPAKLAYGKQRLPGIPPNSTLKFDVKLVSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCR2</accession>
    <name>K1VCR2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCR2"/>
    <dbReference type="HOGENOM" id="CLU_1200542_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCR2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="25494" checksum="95E9C204CFC68D2C" modified="2012-11-28" version="1">MIVLFHPSEQPRSKILFPTHVHPHSHNSLSIFVSTLTTAITTLYPSRASSQTHPPLRSHARHTASAREPTTTLDLPQQQQAASFNITPDTMGFLSSSTSNSSSSTAGSGAISSAEYFAAEHRASMASAQNGRSTPLVLSEPPRPNRDTQYKTKNHAQKSNPLDTLTEAILGTSRAMENWQLKMDKRKFSKSQKSRDDSNLQTRSSGWGLRALKGDFLKSKSDFRAKSEIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDA3</accession>
    <name>K1VDA3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDA3"/>
    <dbReference type="STRING" id="1220162.K1VDA3"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="K1VDA3"/>
    <dbReference type="OMA" id="ELPWHNR"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="39"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="530" mass="58244" checksum="C2368F9D2E12BC1A" modified="2012-11-28" version="1">MSNEKGIHPYDDPEKVDTRAPDADAIVLSQVEEEGLKRGSIGTGLFLGLGGAIATGGPLGALLGYLIIGALVCAVQFAVGETSALLPITGSFVRHAEIFVDPALGFAMGWTMVYGNWLSVPGEISAICVMFAYWTDVTPVTWCLVFIFLTAVVALAPVGVFGEIEFFCAILKILLFVGLIIFGLCTNLGGVPGVERVGFRYWKHPGPFVENIATGAWGRFLGFWSTLISAVFSFSGMESVAMAAAETRNPRVAIPRAVKRVFARVTIFYLLSVLIVGMLVASDDPRLQGYADTAAQSPFVIAASKANIQAIPHIVNAVVITSAWSSGNQALLSGSRVLFGLAVKRQAPRIFLTTNRWGVPWVAVCTNILFSFLSFMTLSDKAINVFYWFVNLVGCGVLISWSVILLNHLRLRMAMRRAGISRHEMPWSNSWTPYASAFGLFFCVILLLTNGYTTFTKGNWDTSTFITAYLDIGLIIFITIVWKVLKRTKYVRISQIPLQTIFEDVHRKPLNDEPEKPSKGWIRLISWLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEM7</accession>
    <name>K1VEM7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Organization and biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEM7"/>
    <dbReference type="FunCoup" id="K1VEM7">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEM7"/>
    <dbReference type="eggNOG" id="ENOG502QQJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349220_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEM7"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="807" mass="89275" checksum="1B16BE0DCCD00832" modified="2012-11-28" version="1">MYVSRFAGDGRVFVLALQPSCTPRILRLFNRPPSHCLIHSTGQRLSDKLLIRQNGVVRASYGSPPRPAPPGSSPRQHLDLLTVCLDSLITSCAPGPYRSLYHYPRLLHETREDVNQSSLTTLHTPPLPARLAEVEHQRVHSSEAAEGWCRGWNDTSVEATRIVSVIVLVNADVNNAAANMSSMPGNPPCNTQDPGTERQSSAPCTYLRILALHSPPHQQELGTLAQSAASTHEGGSAERSRELVATSSHSSEVVLHSRLASIQHGRPQCLLQLVRRWKHSMGHPGYHYLRIRGLRHAQLSPTARARCPLDLGLSHCGNGRDSHVGSMSWFVLTGSFESAIVPKWGASKITFRNVYVSRRPQDPQSDPKSHKTQKGDKSTQPSPIPYLSSLIPPDTYLHPPKAAEADNYTMFDLNFDEIDVTLSFTRWLDGKGLVKDAKIKGVRGVIDRRSVWWDTTKSLEPADYRHPSGPGDFELENFIIEDFLVTVYHPGGQRPFNVSIFNARFKPFRKRWLFYDMLSAESMTGQYDNCLFSLHMPQKLGGPHGDHSDSSHSVKRMARFRIDGLPIEHAQFASGNTGAISWITSGKLDAVLDIKFPFHPDDDDVDIMAIFEEIGRNVATITHSGIHPDDAAGDHMSDTIAAIDSCGPGALIPGQARLARPPLRAPGSDSDEQDETKRQVVIDIDLRFRDLKAAVPVFTSDLSVTNNALIRPIVAFINANRTLIPIHCQVKAELKDFDGSWTLFEAGLMTSISNQIYSALAHHVSSEAANSKRLRQVSVWGIQRGAEVLLEALKNMVDPFNHQVATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEZ4</accession>
    <name>K1VEZ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEZ4"/>
    <dbReference type="STRING" id="1220162.K1VEZ4"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_5_1"/>
    <dbReference type="InParanoid" id="K1VEZ4"/>
    <dbReference type="OMA" id="TRWIESD"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="67"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="181"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="419" mass="44974" checksum="A9699EC2CF165886" modified="2012-11-28" version="1">MSSIIRSATRRMRVQRMRTTPLVSSAARIIVPAATPVVHRRGLATPAAPSPAPANAATNIPSQDAKRLKKVLIANRGEIACRVIRTARELGVRTVAVYSDADKDCLHVEMADEAYHIGPAPAAESYLLAVAAASGADGIHPGYGFLSESPEFARAVAAAGIAFIGPPAEAIRAMGSKRESKEIMIAAGVPCVPGYHGAAQDEDTLVKAAADVGFPLLIKPTHGGGGKGMRVVRKMDDFLEEVRSAKREAAKSFGNDEVLLERWLDRPRHIEVQVFADSQGNCVSLWERDCSVQRRHQKIIEEAPAPGLSMEIKKDLADKAVAAAKAVNYVGAGTVEFIMDAESGEFFFMEMNTRLQVEHPVTEEVTGVDLVKWQLSIAAGNPLPVTQAEIPCLGHAFEARIYAERPEESSSPTRLLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFN9</accession>
    <name>K1VFN9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFN9"/>
    <dbReference type="STRING" id="1220162.K1VFN9"/>
    <dbReference type="eggNOG" id="ENOG502SYIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041939_2_0_1"/>
    <dbReference type="InParanoid" id="K1VFN9"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="262" mass="28764" checksum="EDCD81553D0BBB56" modified="2012-11-28" version="1">MINHSSLQEFNCPKPEPIPSATLNGKLYYRGGKPPVGKLQPGKVDLMLFAPLRGLNENEEVKFLYGPHSNAMLFAEYGFTETHDDSEDGAGVFWPNGDVDVNPWVEAMWESQLGGTEEGERKRAFLEDEGMWGHNRLAANGGEPAPSTGLMLTLLVMVTPPEEFPTIVATSRHGGLKSRAFTRPLKQAAYRQLAGLCQDVLLEALESGKKVDKLAKTIRADDEDRNSKEIAVRSVRGLIREQESISRTILDVVESGAGIPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG72</accession>
    <name>K1VG72_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG72"/>
    <dbReference type="STRING" id="1220162.K1VG72"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450552_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG72"/>
    <dbReference type="OMA" id="GCAKTIP"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001297">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854128" description="C2H2-type domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="613" mass="65836" checksum="FF208BBC0AFD2403" modified="2012-11-28" version="1">MHTHSALVIGSRLITALVRVVRLAGHAHKPLWPVHKPPDTRSLLKSRLAPFPGASSLSSSSFLFPPHPRLSHLRKRRSLQTWRSSQLPLQHRALHLLPTWGQYPSQPYTLPPGSPPSSSSPFAFNSPSVSNPNSSRTATNMPSEQVPATADYYQRPAAPGAAPNGAASYPNYAGSHPMAYRSNSETNRAPPPAPLTRVPTYAMMQQQPNSVGQPSPTATSPYYQASPRGPGGAYAANSPRTPAYSQGGYYSPGYSQAPQALDMPRSLSYPNYTSNPYTSYLPSISTPTLLAPGEQLPPLARQHSTNSINTLGQPMYGGQYGSRLPLQDRPFKCDQCIQSFNRNHDLKRHKRIHLAVKPFQCEKCGKSFSRKDALRRHWMVRGCRGEEGATAPITPAYPLNNPPPALSPSTPPANSDKSTPAGAKQAPSSSLYGSNTMSFSHPSAPPPLTSLPARQSSDQPSQIILTPNDMAAQQRSASDSSANGESVVIDPALSMESGAFGGSASAGPEGDKSYFELMRKQNSMGGAVPDSAVSSTFSRYGASPKDESAPARHHPYRRTGGPLPSPSMHSPLAQSFAHQQQSNPNLLAPINSTSMSKQSSADSADPQWGSQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGG8</accession>
    <name>K1VGG8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGG8"/>
    <dbReference type="STRING" id="1220162.K1VGG8"/>
    <dbReference type="eggNOG" id="ENOG502S9QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491065_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGG8"/>
    <dbReference type="OMA" id="MFPDFDV"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="555" mass="56963" checksum="88F9B45740C454BD" modified="2012-11-28" version="1">MADTTKDQDTKAALAEATATDLADKPAPNEVKGDKFSETATKAAKDASASNDSRNSKESKGTKDAKDAQVTPDATEEDDDDDSVKNVPVTAKSAKDTPAATTDVQSATPKAEDAESPSADGTETTTPASAPATPSAPAVPPAAPSPAPDASPEVRELHAMFPSIEIGVIAIVLESVGGSQDRAIEQLLAMNDPDFRPDDASARQAELDRQADLDAEFARALIMQEQEDERAQRRARPAAAGGIPSDPSQLPYQPRVRRARPHPDAEHEGQHGQHGQQGQAHGHGQGEDQFAAFEERVTQIAEQGRQTFNTLFNRAKAKYDEFAAQQQAAAAARQQAQADGNGGPAAAGWQNRASGAAAGAVAGASGLAAGASARLNALWGTGQQQGQQGQQGQQGTSPSGRPARWSPTDSYEDMHDAQPLSTGATINVGGRASPRDGTSPPPTGPGAQAGKIDMAKLGFLPKKRVDLMSASPSPAAGAGAGAGAGTGAGSGNASATSLASGESGKSLVDKIPKSPVGETSPHTLGDSDDEELEYTDGSLMSQNRPMPGAQKYLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGX7</accession>
    <name>K1VGX7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="7">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGX7"/>
    <dbReference type="FunCoup" id="K1VGX7">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGX7"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018705_3_0_1"/>
    <dbReference type="InParanoid" id="K1VGX7"/>
    <dbReference type="OMA" id="QDRGDTF"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="10">
        <location>
            <begin position="219"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="9">
        <location>
            <begin position="483"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="685" mass="76169" checksum="2B9451A76BDFA4A6" modified="2012-11-28" version="1">MSTEVKLLTLLNVSAIKRPRELDLPGGFRSPSTSRPQSVDGAEPPAPKKKRGVVFGGEIGPSGSTYGKKGKGKKAVKIAVEGDEGGDEVIEEEIVEDGEDEESAEGEDDDANDDTFNTHFGPETPLLSRIEEANEGQWTQHRATIKGLGRVVEMRPGDAPAAEGSARVVPSISAGLKKSTHAGLASSYLQQLGRYTDLYAHSLDGEADGSEKAPWGPKREALRAATAAHLMNHVLKTRRRIVRNNEKLAHALDAGKDMEPPRDQSFTRPKVLLLLPTRALAIRWLANHLFPLAPEGTQIENLRPFLSSFGVPEGEEPDLSALPADHQENFSGNTDDNFRLGLKVTRKAWRVVMPPTTEAKLLDCDVVIASPLALKMAQEREKSVDFLSSIEICAADGLDIMHMQNWEHAAWALKQLNHIPEQPHGCDFSRVKPWYLDNQARFLRQTLLMSRYDSPEFRAVFGACENVAGKARVDASSALEGVLDRVRPGVRQSFERIATEQRGMGPDAALEELDARFEHFTKRTLPALLRSAVQRQHTLVVIPSYFDFVRLTNHLKKQGTLSFTAVSEYSSNSEISRARTLFFKGKKDFLFITERFHFYRRYRLRGAKTVVWYALPEHAQFYAEFLATPFIPGKGQTEAEVDVDPAEVSSKALFSRFDVLKLERVVGHTDARLMLSSSDSKFEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHF1</accession>
    <name>K1VHF1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHF1"/>
    <dbReference type="STRING" id="1220162.K1VHF1"/>
    <dbReference type="eggNOG" id="KOG1398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608572_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHF1"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="450" mass="49309" checksum="3DFD5AA2DA2BF5D6" modified="2012-11-28" version="1">MPKKRNNKASNGHRRSPSKGKATPSPTPTPPATDINPAPESAPVPPQQHEPNSKVEVIQPSPPNPTPTDKPVPVPEPDANEPAIMPPREPEPESQPEDSTVLVERPEEPLTAEPVQLHGQAKEELHRRAEEQVEAELEEAEMASEIADELVELVESIADSETEAMEAIDTIAAKSGATTIASVQESSHEAAEAAEDAAQEAEQDTGAVEGILLNSGASSTPTTPPRSNGHATDEKHADHEHDQHDQHDEKAAHPHLRRAASTSFVASCLSTSPNSHGRTVHKHLRFTSADEGQDEPQHHVYYPRKRNLNTSDPGTPSIAETAHQIRRTISFASFDNLVQLHTNPDQRERFVAEVARAGRELVWRDKDDHPLYPRDGEQTFVLASKRALRKPQKVAITDLRLLHSLVHGAIGRQRCAAPVQDAGTAQEAHCPAAPHRHHRRGQLALWCHDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHT7</accession>
    <name>K1VHT7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHT7"/>
    <dbReference type="HOGENOM" id="CLU_1367109_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHT7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="22265" checksum="612DB6DBF1B55F19" modified="2012-11-28" version="1">MLATPRIKLTPVAPTLGNPDQVRSEETTIILRKNAWDWGDTDGYTIVVASATPGSARDKMEVLNEVGTHLYDIKNRISVHRTMQGKRDQHEFFEMQNEKTQKGTTDHESVMTGWWKDTSGTRRFAIKGNWYKGEAVVWLSESNHPIGTILTADSQEGYQRVGGETKGEEDYQVRVAPGVDLQVFAGICIAAETILAKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI52</accession>
    <name>K1VI52_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-nucleus import-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI52"/>
    <dbReference type="STRING" id="1220162.K1VI52"/>
    <dbReference type="eggNOG" id="ENOG502QQM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017588_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI52"/>
    <dbReference type="OMA" id="DAKYRKC"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hook C-terminal" evidence="3">
        <location>
            <begin position="166"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="576"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="988" mass="110446" checksum="22CFEC7203E842B4" modified="2012-11-28" version="1">MSRQEKDALLALFNSFRPSRRVTSFEQLSDGKVLMEVLHQIDATHFKSGPKPRPGSMSGAVNDNWVLKMNTLAPTLEVTSLHEPNFNAIARNPRSAEGSAGLLQISRFCVAVGAMGPSNERVIAKIQALDEGSMVELMKTIEGVMATLPAPVEDPSKADEISPPFTAVRNERDKLISENEELRARCDQLTEQVSSLAKQMDAAKQEQEAEHRASVDSATARATAAAQSAGEAELLRADLQRAEDGLAQTEAELEKQTAIIAELTRNCEELKATASEVSRLREQVEESKQVEERLHRSENVIEKYKKKLEDSAGVRKELRQLEQENAALIDKNSALEVDLRKLSASRAMVDNYRAQVEALEKRVNEQAEEFAHLTVQLEEAQTSVATLERERDRLRDEVHIHQERIKELEYAPARRESAISNEGDMSLKVELEADDVIEALSKPQLRLRIRELERKLANAKGSGDDSDRVTTLEGLLADASKARERYQADYLEANRNMLLAQAKLEHILSGKAGDAKQTASAMQQKLDDMAEEREKLYRDTQAAEDAHADLVRQLTAAKADLALVDKDKRSIISSARDEAKTETAKFSEQVNNLQEEIALLRERDRLHLEEIRRLMVDKIELQSAGFERRLSEARSSLDGTLSPKSAERDGLQRRNDELLTEVAKLTDKLKKARAFIKNQDALFRADHDKRLESGTQETAKSYETQIQQLRNELSVAKVGLLRFEVANRSQHNALSLDSRYRLEQQLMLSAWHDLGARVVRDHVGAAGLRRPVNLGNESLLEPPSQRLGRLQRHPFLSGDLPPKLELGQPGTAGRRDKDGHVGLLPDVFQVRQKSRNAHLHEIEHTEVDSLHPTSLAMVLYELFCIASHNPQTPVSSTLALCRLLLPPLLLARDLPRGCSDFSAIRFSIACTPHRQARKPQKKDGETGDTKLPRVVALTSQQNLRGLIQNIARKVHLQGGVVREVKGLGIGLTLPERMKRNQQAHDVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VII4</accession>
    <name>K1VII4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000339">
        <property type="protein sequence ID" value="EKD00576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VII4"/>
    <dbReference type="FunCoup" id="K1VII4">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VII4"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="K1VII4"/>
    <dbReference type="OMA" id="GMAGTMF"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57629" checksum="1E7655F15617B0DB" modified="2012-11-28" version="1">MHMPTSFPLYFILITRKIDKHAASIAVPAAILRLQYPLYDPRIGVATQHTPGLAVGRAAPVPGREEAAVQAGPGHSPLARSAGSARSRQTYSCVSFWVNYLDRGALSNAYVTGMKEDLHLHGHQFNVVNTCLTVGSDIIGQVPHALAIQAVPPRLWFPSMVLLWGLLTMITAAARTFAHLCAIRFFMGLVEASTYSGTQYVIGAWYRPEEMGKRTGLFAASGMAGTMFSGALMAAINCTLDGRRGLPGWKWLWIILGCMTVPVGLVGYVVFPDLPGTTRAFWLSESERRLAVERLPKPPERSEGHRLGMDLARRVLLRPEFYTLSLFWVIGGALEAFSTQSCMLLWMKAVGRFTRAQNNTYPLGVTAVGIVATLLTSVGIDASGKHMVWGFAACALQIAACGMLIAPRLRDGAVFAAYSYMIQPVCFTWANKILLRTGDEAARAVTLADARFAFWGIVLYPVPDAETLFRKGTIAMFVVSGLLALWIVVVWYLEKWVVRRVPPPKEEPAIEIEIPGKDSDLSITKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIV7</accession>
    <name>K1VIV7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIV7"/>
    <dbReference type="HOGENOM" id="CLU_1994217_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIV7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="125" mass="13726" checksum="9899284F1D024F64" modified="2012-11-28" version="1">MVGGHPWPSDPTEPLGVNHPLDEIRGLAYFAALEGTRVTIVNAALADLSNGRRACNMGDVVETLTQMWTADLRDEEMADGAPIDEQQVLGMIEFISLQEYRERVGKTTFAIETMTDATAQVPQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJJ6</accession>
    <name>K1VJJ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2C 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VJJ6">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJJ6"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255390_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJJ6"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="608"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="908"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1384" mass="149867" checksum="39EC93884EC856E4" modified="2012-11-28" version="1">MSQQGGYYNQGQPPPTGGEQPPQGYSGGYAPPSDQYGQPPQSYGGGPPPQQGYGGPPQGYNNAPQGYSGGPPQGYSGAPQAPPQGYDRGATPQAGGPPQGYGGAPQSAQGYASAPPQSATPVQGYGGAPQAAAPAQGYNSGGPPPAQGYDSRYDQSRGDYPAQGGYQQQPPAQGGYAQGGYQQPPASAPPAGPPSDYNAGQYQQQGYAQQPQQYGEPRQQYDSRAPSAAPSNDQRPPGPPGGAYDQHAPAPPAGQAPYQQQQYYDASPRPGTAASTAPSVAPTISTITPSMAPSMGGPPSTVAPSPAPTVREVGPAPSGFNPAAASFQPAGGPPQAPYAQQGHDMSGLAPPPSAQGTVSSGTTGTISTRHDATPATSAGSEVPNVTDKLEALQLTSFYVRPGYGEKGKKIVVQSNYFAVTNTKRPRQLLRAVWEQLAAEQTHPDWQRGFKAVAFDGRKNAFTPHKFPIEPYRHTTTLLASGEVQRGGQQQSSSDEESRRYHVDMKLVATIDLEAVMEFCRASDRAPTNEERCLTGVMATNVLLRDFPSKTYTQVGATGNKFYTMDGSRPLPQGAMVCKGFLQSFRYSNSAVPLINIDLGFSAFLQPGPAVEVINKILSFGPVGARGGGPQARELDQLDQRQIAILKKKLRGAKFYVTHRQSSRLHTVVTVTLHSAAELNFVIEGKDGNPDRRVSVAQFYKEYYGCEVRKPRLPCIQYGKRAYIPLEFAVFADFNSLPPTNLTAEQTAEMIKVSAMKPNDRRETILNWRRELAYETQEKVREWGLEVNQRMVETDARILDPPKVTYRNNRAAPVMDGGWRLRGVQFARDGLRPLNNWAVVSFDRYCDVQDMQRWITYLCSALGRLGVQVANKNPPIIPPADPRQHSNLLSSMQSAARDAFMVSGETPQLIVVILPGKDAWLYESIKKISFTELKAPVPTQCMQAAKIKSPRGIEAYTDNLAMKIVAKLGGLSHRIPAESLPGMEKGKTMILGADLGHPPFAPNSQIPTVACSIATYNAECDAYSAQIRLQLGRSEIIHDLSTMVEEHLRIFSKNNNGDYPERILVFRDGISEGQYAAALQWEHDAIVSACRRIEGTYRPRIMVVVCAKRHNTRFFAKERVNTDRTGNLPAGHCVDKSVTHPYAFDFFLQSHAGLVGTARPTHYICLLDELGLTPDDLQKLVHGLCFSFARCTRSVSLVPVCYMADLVCQKARLIVQRADESMTPSETSGSRAGAPTATTSTSTIIKTARGDMDHNHIQNMLSRNPEIGEVLMAPPSHLDSKLTYRPGGFRAIVCIQITKHTALRYIHLNTPQHASGSTPPASSTPPALGRRRLGSARGTVLALGGRGGLLDRALDARERLGRRREEDELRLDERGEVLQRFGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJV0</accession>
    <name>K1VJV0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJV0"/>
    <dbReference type="STRING" id="1220162.K1VJV0"/>
    <dbReference type="HOGENOM" id="CLU_630363_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJV0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50551" checksum="954526E991A16C27" modified="2012-11-28" version="1">MFRLVMAQVFKRRMEYLVTYFPRCEEQHVPLLCMLCSSMIIGYSYHDKKETLPITKDELWTINSDLIQLMDNPRSYPEQHQLDFCEALLLNTYASSVGPGASPAGGWLAIGRLHHAALLVGLPKHHDETLQLSHVLNISPILCVHPVPRPAFVTEEALAKMYDAELAGTPLSEFPEESGTCEWAYVHYTADWWAAQLQVGHIMDPTTPAASLRERLDAAHSVYDEFNATLPPHLQLHEPSQQEPPWVFAQACAMLITTAHAVIDLYRPYFLEEAVALRRALHAAESLINTAQALTAFLMFRWIDAQSAQLWEFGGKVFNGGLTMAYALLQGTPEWGSDSGFETSPASESGAGTWRSQQQTALETAIGALRACANQKTHCSELSRKSLKVLEILRTVILQRQAGKEPTHDPYSQIISVLNQDNTEELEDWVKWDGIFQELFTGYNDILQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJY2</accession>
    <name>K1VJY2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJY2"/>
    <dbReference type="HOGENOM" id="CLU_934428_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJY2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="297" mass="31438" checksum="9632939BFE9B08CA" modified="2012-11-28" version="1">MPRDRGSPTAPPHDPVNGQQEFVNSHAAHSQNNNQQFNHHEANGHRTDAAHVTTQQVATAPVDDEGNPLAPLEIDDDLLPQALHAQLALSRARQTAAELAAHGLEAENGILRRALAEAEADAAPVRARARALQRVSHRQQRLIDLQWLMLDRRGVEVPHSVFGEGQARTAAAAANGTNTNGTGDTEGGAPTSSDADNNGGINAEFQAIDAMTLLSRTERSLASASDSLSALGVLLQAGNTTVGHADIMAIKGQIDGLHRTWAPLPAFHYAHASLRGNAAGQRLVDGLGAIEAYWTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK73</accession>
    <name>K1VK73_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK73"/>
    <dbReference type="FunCoup" id="K1VK73">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VK73"/>
    <dbReference type="eggNOG" id="KOG4143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085469_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK73"/>
    <dbReference type="OMA" id="ESEWMFN"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="27835" checksum="82CF84628439BF36" modified="2012-11-28" version="1">MAVKNGKGKANSATNGHGGYDACKSSCASKLSVWAVIIAVVWGLCKVADKLNDGRFYIFDPTELHQCVNASLATAAAADQTQNASFIIESLLDNMVKQYPDAHLLTDYTDHHEWVFNNAGGAMGAMYIIHASITEYLIIFGSATGTEGHTGLHTADDYFHMLTGEEWAYEAGALTREIYKPGSVHHLVRGVKKQYVITPESWSLEYARGWIPPMLPFGFADMMFSTLDWGTMYHTTRITAREMISNLLRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKZ8</accession>
    <name>K1VKZ8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKZ8"/>
    <dbReference type="FunCoup" id="K1VKZ8">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKZ8"/>
    <dbReference type="eggNOG" id="KOG2671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029646_3_0_1"/>
    <dbReference type="InParanoid" id="K1VKZ8"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="190"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="489" mass="55639" checksum="0C644764D88DD1B2" modified="2012-11-28" version="1">MPQYFLRSSMEHLTFRIPELLSIGKLFDFPIRFITPEEDLQRGVIVIELDDEKHIQHILDRSILTISANELYANATNYDDLHARLQERRQLFDPDMDTSFRITVECVNNRALNKRAREIINSFAWTGLRGKIELENPDVEFVVLEDYDFVTIHTKDERLKRDGKFEHVYFGKRVGVSRARPLINVHDIKKRAFFGNTSMEAEMGLLTAGQTLPAPGKIMYDPFVGTGSLLYAVAHWGSYVLGSDIDARQFRGKQKGKDVTPGILRSAEQYGVRDKFIDTPCFDVTQGPWRRGGWLDAIVTDPPYGVRAGAKRTGKSATRKRNQLRDEPFMLPDGTWSHEKEGYLPPSKAYELVDLAQDLVQLARYMLVPGGRLVFFLPTISDEFEHVDVPVVEGMREVKFGDGSVQDFGRWGRRLITMEKTAQDDGPPPTFGDHSDLIGEDRIPAHHQFAKRYFEKPERPEKPQWTAPGAALKADTVEAVTAETEKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL16</accession>
    <name>K1VL16_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000354">
        <property type="protein sequence ID" value="EKC99956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL16"/>
    <dbReference type="HOGENOM" id="CLU_1157092_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL16"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26091" checksum="24E6353563170D8A" modified="2012-11-28" version="1">MRDDQNPVKSTQPRSTGNRYINSDATSALQTFPISSTRHHPTSPCSTSTSTPTSTPPCSTQLRPRPNFDPALLDLSFDPTPLCGWDCVVPFRVGPPVGAAQAVVMQTCIMAAPSRREVVRPSTPTPTPDSDSTPTCLLDPTRPSVVVSTTLHLTPSFKTLDSASRLSRLCLWHFTTTLSLSRLHLRLPQDTLASFCLWHFDPRLSTFLKFASSSSRRDTVTLAVALGVDRPSSSVGPQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLB6</accession>
    <name>K1VLB6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLB6"/>
    <dbReference type="HOGENOM" id="CLU_576444_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLB6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="474" mass="53937" checksum="3DE945A3E4261DEA" modified="2012-11-28" version="1">MQPSSFPTVPSTPQTQTASQGTFSTPFTPTPDLRQSNPQGAPRPSTLQTRARGPILVEGEHYWILRSKHWERDATQWSPSSAELLLSILEERPDLWSQWQAGKNKQGQPARKSQVNEAIVAELRKRKAPTARSAPAVQSYMRKMFENYKDAHKQDIPRTGDGVECYIEIAKDVSRHCQTQADIIEALHEVCPNYHRLKIIMEGSAGAPENTIHDNLELGEGDVMVDTIVNQLGGATEDEPETQETQDFFEDDDETSLHDINEFQSPEPPSTLSSANLDAASMLDGDISPVSTLMASVFGQAHREVKELTATERKRFLEKSQTPESTFSELYSDESEKNRLAKKEKLQVLREQNTIMKRKTDHEIDSGERRLFFEELKLVNEYEMQLRRQFSETFARDKSLSPAQVIEAVDQALVNPLRRMREQLASSGRRREEIRAWDRSRGSSRVRDSSPSVNDRVRELSISRTVYEEDFSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLM9</accession>
    <name>K1VLM9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLM9"/>
    <dbReference type="HOGENOM" id="CLU_2832983_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLM9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="66" mass="7223" checksum="71C87E893F7FA3F7" modified="2012-11-28" version="1">METLIDLVEPDAPTAPSSTSCDDDVFTVPSAQRGEADLIVLYDDLLDLDTPPSTPPQVVNHYLDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM70</accession>
    <name>K1VM70_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM70"/>
    <dbReference type="STRING" id="1220162.K1VM70"/>
    <dbReference type="eggNOG" id="ENOG502SG9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277454_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM70"/>
    <dbReference type="OMA" id="YYPARII"/>
    <dbReference type="OrthoDB" id="2596880at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20395">
        <property type="entry name" value="Tudor_SpCrb2-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1143" mass="122655" checksum="A689F5008469A054" modified="2012-11-28" version="1">MPSNIQNESLDLNDEDETQQPVPAPLPPKTAASTALPLKTTSLPLKSTLPLAPTKPKMLSTSALDEPSLEETEKDEESILFSDPQPAPLESQPVSQRARWATAAEAEAETSIIEEPTDTEDNDEREDNELDASRGPEQLKESSRAASPTPAEKEGASSAAAGANDAYTSDAAPSVPTQPSPRDTTPPSHSEAEDREEEEAESVSSPHSPHDGASPPLFSPKTPSKTSAKGAPLTPLSGLARPNFDPKARNTQTTPTKLAGSVKATSARTSPQSVRQPVFPAASSSRQRDLSPEHEESSDFASDMHYNPRGAKAFKSLYEKRSSFHRGSPFQHDDDVPTDAQASADASTDEEDPTDAPAPTDPTTDPQSVDLEPTFINGQSSSQQWLGGGRSSPTRNTRTSPLPEPQPTAEDDSGQAPRDDMDIDRPVVPPSSPPRAVPIPSSPPPGRLGDLPNSEDGPLNVPGDAELFGETMDSEPSPHRSSSQSQNYSFQATQVLNPAMESQSPIKSMPTPLKPTMSTTSAASRVSEGRLLKRRNRSSAVPTPPVLPRSPSPIPDGAETYTDTYKDPSGAAPQQPPENVPAEPEKERSTHSIATEVGADEQTAHVEEDMDVDPPQDPPVLTGIHEIETGSIEHDPVARPSPNKYGRKGKGRQVADSPLPSSSSSSAQSDPEDNTFQPQTQTQEPSLSPLKGKGKAPSSTMTSPSKASKGSRSSRIPSSGLRGSHSASVTSNRTASRPSRNKRKNLSPTPSFDGDSESSTSGPEDPEDETFRPPQKKAKKSKRQPTKTESKSTRKAAKTKEPEAGPSRPRATASASRTVRTPSAVPTPVPIQQDSEEEPLRVLALWTKTRDYYIGTVTARNKTGYRVSFDDGLNRTVPVDRMRLLDIRKGEKIWCGEKQYIVDEDFTGNGEIFAFDLKKNPFSIQTKQLAISQSDIDKNYGDRLVPLIELESRFPTVTASGKRGSLTSVAPEDPCTEFEGKVFLITGDVKDSYKTKIEAHGGVVVPDWESVFTLTGDSYELSAEGVPFLIQNAEPGTTMTPKVMAALAAGMPILSSAYIDAAIEGPGPVCWRNFLVAAGYSASLRAYASQDIADDWGGEGWVAASAKSKRQPLVGKRVLFVEPSAKFDRGRSLKVSYRIWNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMB8</accession>
    <name>K1VMB8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase (NADP+)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMB8"/>
    <dbReference type="STRING" id="1220162.K1VMB8"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="K1VMB8"/>
    <dbReference type="OMA" id="EIRITHC"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="124"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="30498" checksum="549764E503A17764" modified="2012-11-28" version="1">MSTTTIPAWVALNETAGDGNLKFQDVESKKWDDDNIDGEEQFCPQMCWTYLSPLCVGNSKGMINQGGYAKVWRGSARFANKVPDGMDPADAAALVCTGITCYSPLKRYGAGTTAKRVGIIGVGGVGHVGIMIAKAMGADVTAINRGTRKEADALKLGASKYIATGSDLEKDFEGHERSLDLIICTIIADYMRLLRPMGAIVVVGIVPDPISIPSRPLIWSGAAVAGSPIGSPGEIKEMLDLAVAKGVKPWVQKYNMDDINKAVKDMKAGKARYRFVLVNTDNGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN56</accession>
    <name>K1VN56_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN56"/>
    <dbReference type="STRING" id="1220162.K1VN56"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367444_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN56"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="402"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="769" mass="82798" checksum="82779E7EF5693004" modified="2012-11-28" version="1">MKNIVIVGANTLAKRLPDDYRVVLIDANAFATHLPAIVRALVVPDSEKKNLTADLTTATVFPANSRHVAVQARVVELKESSVVLDREWEGSTEVFFDKCILATGAWQASPMRPGLGATRQGYLSELRESQSSFGKAERVLIVGGGAAGVEIAGELSTHFPEKRITLVHSHDRLLVTKGGYLVPEWVSERLHTQLEARGVMIHLNERVAEKGGAYFTSAGEVVADYVFWAVGNKPNTSLVHPDHLTSTGTVIVDDQFRTPLPGVYAAGDACSTPGRKTAGLANWEGAACASAVLAHMSGKDARQRAGKINNGILIPLGDGRPTSIPGDGIGAGAIDLGWFGIWVARGGEWGDMHRVPAVCGKNKGLEVDKWGSPRGKPRLPRHVDNAHSPRSGGMKNIVVVGAANALAGSLWRGDRVVLIDANDFAVHVPLVPRSLVTGEVRSAPLRTSTVFKPGHHVVVRARVIAVRDGEVELDTEFEGSTRIKFAACILALGSAGIGKPELGMSLETYKRGIEEESETIRDAKEVLIAGGGPTGVTLAAELTQAYPDKRLVLVHCRQYLAYSRRDGESYQLTEGQKAISEQLFGPLCARGVWIHVNERVSPDGKMLELVGTPVTAHVLWCDGPKVAERTDLLDRNLVGPDGRIGVDEYFRTKMPNVYAVGDCADTEGRNTIAQAMREGAACARILLAHLGGKGAEYDQMEDETYVVPLGPKGGTYPRAVDGYEDGAGAGIVDFGWLGTWPAPDWYLTRMHRDYFHSSFRGLFKGAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNC3</accession>
    <name>K1VNC3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF423-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNC3"/>
    <dbReference type="FunCoup" id="K1VNC3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096548_0_2_1"/>
    <dbReference type="InParanoid" id="K1VNC3"/>
    <dbReference type="OMA" id="VEYQFYH"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13002" checksum="4ED3525FA618A296" modified="2012-11-28" version="1">MSASTLFRTGAAFTATGMSLGAFGAHALKSRYPEMSEWTRQSWMTGSSYLIYNGIALMAISAHPGLAFGSRKIKWATGGIIGGALVFTGSIVGLVLNREQLGKILGPMTPMGGVAMIAGYIALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNY2</accession>
    <name>K1VNY2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNY2"/>
    <dbReference type="eggNOG" id="ENOG502S87A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1403340_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNY2"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="8">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="194" mass="21311" checksum="0ADB8AA1909218AF" modified="2012-11-28" version="1">MRRRSFTDQPLLDEQGNPSPAAAVAAERRWWDFETIAPTPRDKLSLSLIFAGLALFLPTVWLLVLTDNPSSKPYFTPHAPLNALAISCFVLGIVPVQPPTPGAVLRAERLSAHQAWLLGLGIPAMLVGTGFMWYNKENNGAEHYTTWHAWFGCLTLTWALLQAAIGAGSVWAGGWVFGGGARARSVYKYHRPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP57</accession>
    <name>K1VP57_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP57"/>
    <dbReference type="STRING" id="1220162.K1VP57"/>
    <dbReference type="HOGENOM" id="CLU_298797_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP57"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853953" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="940"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111679" checksum="93ED6462DDF6A0DE" modified="2012-11-28" version="1">MRLDYGAILFALATTAAAAPMTGHDNGQGGVQHEERFKLIGPKNPLYTPDGERTGTYLPPLNSHHLVTYRIASDQANSQDGIGPLMDLTDRPHDRLPPASGDRQHGKRTYLVPEVQTYRLDHGRLIMDEAHRVYDPKDGKSVPINERSYLVPDQTQGTYRLENGKLIKDEAHRVPDPQPVDGDADAHAKDAMREIMGIMDKHGKRLLMPDLRGPGLPIYDGPNHHVGYKPKPKGQPQPKPKGKPKPKPVSGPFLTWNKHEERSYLVPEVQTYRLDHGRLIMDEAHRVHNNPDPVDNPYNMTVKPLPHHKRESDVQLMDRTFFDPLARWWRFGSLRDKLAQHNQEKKNVKREANEQLEERKLHSRFALLPDIPLEHEVNPAWQRIPAQESGNQRHPKFDFGQIQMLRRHEGRAQIHGTYGISDEAVESPRLRTAPLGQLKHHHDDDKTALEERTYLIPGVRTYRLDHGRLIMDEAHRVPDSTPSLPQNQKRSNDDYGIAARRLAPWLQEQIIARAREQLLRDQGARHTQHGIPDKFDTYWKKGKRDGGLSQDELETLSNELESQLAKRLMLTPTRRPRPRPLSGWPNHGPKHPKLPVRNIWLPKSPRLLLVHENERKTDIQKSSHHTPFPFQAIKGKRDGGLSQGEEEELNSEIEALEARRFMLPPRPFLPPKWPSAGTHGVPGSVPGAEGTPHSDSHNGGKRPWGLSPAVMVKRDDTARVNSAIDEWAESAHTNPTAWADNAEKVLKAAFPGIRISRTDKPKDKRENGVPKATAPRPPKRILSPEECRIRQQQDEEMRAKHRYVKLPRLPSECGFLYKRDEDTADSTAEAGPKDGSERNSSPETAETSENDHEGSTGSTDSASGDDSAAVYASDSGSSSVTGSPLPTSTSSLASRPATTDDATKKAIDAVCALVKSLSSGSQSNGQIKGLASLCEKLQDGSASTTSTGSASSHITSSAESGSDSTSTSSGFDGSSTSGASSASGSTSGSSSASDSSSTSTADDASHTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP92</accession>
    <name>K1VP92_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP92"/>
    <dbReference type="HOGENOM" id="CLU_582910_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP92"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="469" mass="51628" checksum="39601C4345AEFCF5" modified="2012-11-28" version="1">MLFWHQNPCNLPPYPQENSPMWFHMARYLLQQDLNARVEAIRVTWSGRRQLAYQNLAGDMLAQAIAASHANEAEEIAQVHREFEANWHNLNLNPILLVETFHLHNISNPLPPGLYHCSTLAPVPTTPFSNRSPVLSMNNDVASNIETSRLDNQCDEIHAELSLRRLMEVIKARKDMKHKQMLSDMEAAGVGAMDSAGEGSSSQSESVTSVSVDAAQSNEDNIELLQQKLQACKGAFASVLAIAMDISASLDMPDAGIVQDELSDLDDDFTLAMMVADNILTLVTRILIPMNPSTITGLHWGIGALSVTRFCGFAQGLIKHEDSRLERTEEGCVRTAVAKGCYSWTALAAMYNGHHLLHFLSLLSYTSIMNDEKNTTNENPRDEKPGTKSNDIQQSCEPDESTTGSMSKVLATRASAVPIEGVSTFATAADARSAILEYATRTAKGLTTNEDTLRALDNWVAEFNRVNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPJ6</accession>
    <name>K1VPJ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPJ6"/>
    <dbReference type="FunCoup" id="K1VPJ6">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPJ6"/>
    <dbReference type="eggNOG" id="KOG4067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084839_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPJ6"/>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="190" mass="20693" checksum="585E5F1B77B370D6" modified="2012-11-28" version="1">MFGAIVAGRLVCGLPSNPGRADRSSDETHFVFLLENPYEIHHLTVFLTGTPFPEGYGATVHYAWPNAPNDWIALGGAIYKVNPPTNQAQGPAQVGIEIAPLAAVDALVQQRAASREKGAEIAAKVDVGKVAEKVVKNVPDVQLWNYLHSFGDAPLTPQTPIPLSVFQKWYDNFTRKLGNDRGASFLDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPR1</accession>
    <name>K1VPR1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPR1"/>
    <dbReference type="HOGENOM" id="CLU_468662_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPR1"/>
    <dbReference type="OrthoDB" id="2563880at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="582" mass="62039" checksum="8809B45D31B14EFD" modified="2012-11-28" version="1">MTNLGKGIGVPSPVLEGSEVMETPRTPPAPSLSPESAARRARATRDTSLSPRKSSFRGVRAASSPYSRQTHRPAAPSSNVSSSSKSSVSPAQRAAREWRAKLVNLSSASPEHTDEEVAATGFGGPRPPPRPKTAAAGNSNPSTPLSEVPPSRPRHRRRSLDSLVSVSTKSGRHPNVSPACSAFGDAFDEQRLSIWSADFDALSLHAASVSSSTVSRVSRGTNKSMKSNKSKASTNLTMVPEVPKIPDHMLSQLSSQLSSISGVEPLVPTSAVGQGAKYDNGSMLSRSTRGHNRSATEGQSTVVTAVTAATSFPTVSEVTASTESFSTPEWQPSERFVAVRSSAPNMSPVLDVEEEEPKNLRGLGLKMDLTSLKAKPLPPPPTTAPSTTSPPSLSLEDGAQSNESPYPSLSTRRTSTPDHTEYLVTPTCATVDEKLMSRAGPVVVSDSEGESVPERKQQRPMGPRKNYNGHIRDASDVKMAIALAQQSHKLTRSQSSDSRSKVYVGGPREPTRPSPSVSRSTSQTLVNVAIPRTTSKSASLDHHGPELLKAYDLTPGLEDGGRRPRKKGMPMQDLRKWLETSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPU9</accession>
    <name>K1VPU9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPU9"/>
    <dbReference type="STRING" id="1220162.K1VPU9"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_950572_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPU9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="293" mass="32038" checksum="828ADA979F94BA6B" modified="2012-11-28" version="1">MHSRIGDAEEPAVVRRTIPGGILRVPCEDRVVKKGPARSHRLLVHLLGPIGLAGPRTFANPVQGFCRVQLHAERPPSAPSCALLRPLAPLSLALMHHLSSIPTDPREGTLRGTRVATTGHDLPNSTTRTHLASSIPQPRPTTCSCVYSERRSFFSRYDYEEVESEGAEAMMAHLRELFDSPDFVGKTLKATSSDTSFTVESAADFAYTDPIDGSVSTKQGLYIKFTDGSRIIFRLSGTGSSGATVRLYVEKYSKNADEFAEDAQVGLKPLIEVALDLSKLKEYTKREKPSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ50</accession>
    <name>K1VQ50_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ50"/>
    <dbReference type="STRING" id="1220162.K1VQ50"/>
    <dbReference type="eggNOG" id="KOG1040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014934_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ50"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="938" mass="99566" checksum="052E4C145D261D94" modified="2012-11-28" version="1">MASKSGGDQSVLDTNPHLAHYVFKMLVTSLATRNASGQHPLSVSSSGESDSDDDDHHHTDGHSEHNETASSADEDGQPKAPRSNTSSNGNRTAGPTREEKEDIVRKIIELLDNEQEEDVKDLLRSPMGDLGKTDLRTTRLWTRSASTACTVTEVRLLFLNDAELISDDLSGVPYQAGAFTPTRIRRPYTPTGVGTLRVRTPLARPHSPAGSGAATPTSSHGPSALGRVDSSSSAPVSPSTSPRQALNVKAATFNPTGGPATRNLSNATIGFTPSADPWRDAEPTSRSASPYAFGAGQSMVRTGSGRIMAAPIISDPSSPFHSPLGTPTRTHAKLAGDMFASPAMTARPASRGVVPDEEDDEEFSPFGSGLPKLHHQNDSGLNSHAKPFEPTFGGANHDFHPTGSPLATPYGSQASTSYESKSSADAEDDPNAPPSGMTPLDVLSSVFSTVPRVQLEDALHRAGYDFEAAMAMLVAQYAHPRSGASTPQRINSPRPLIGIDGRGGPQHAPGPGYFQQGGRGLGGNVNSGMGGPRNTGPTRMCRYFLNGECRRSDCRFSHDLDRALCRFWLRGHCAKGPSCEFMHNLPNNMDPNQLNSSMGRMNLDSPGGSIPGTPPIQGHYGANHGGGGGDDFPDLLAARLNRHVGRFDPARNRFANAVKRPAPAPPPAGVIHVTGAQPRMVSAQGQGPLGGDRTPNNAPASVPVVPRPSNRVKLHAPTLLPTLATGSAANEQYMTARAASIRLGHARNACLARAADAFRRGDGAAAKRFSREGKALNEKMLHEAAEAANALVKDRMHDAQRAVRERDPSWSDDPRDRTERGKECGSGLGVVLGVASAGKVPGGDRLSSEERTECLLDLHTLHGSEGAELASHFLAELEREHYRGLAYIVVGEEKHVGQQDPARGASKVRLANSVKQFLAEWGYAWSENAGVLCVDPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ73</accession>
    <name>K1VQ73_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonhistone protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ73"/>
    <dbReference type="STRING" id="1220162.K1VQ73"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229875_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ73"/>
    <dbReference type="OMA" id="DKWKQAY"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="234" mass="25188" checksum="8552F35B468E6B90" modified="2012-11-28" version="1">MAAMASYEEMEAKRQEMMASFKDIANAMTRCVAIIEEYARLSPSALTTSAALAAVEGGAMGAAEVLAAAAMANKKSRKQKEKKPKDPNAPKRPPSAYLLFQNDIREEIRQAHPGMPYKEVLSVIANRWKDLDEPARKDAYNEATTQYRVAEEAYKGGAPATLGAVVSDVVSDDSSSEDDSSDDGAAGTAAKVFPTVATPVLPTTPQSTKKDKKRKSKDESTPADKSGKKKKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR95</accession>
    <name>K1VR95_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR95"/>
    <dbReference type="HOGENOM" id="CLU_2308029_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR95"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854310" evidence="2">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="100" mass="10292" checksum="77ABF3AABA095B00" modified="2012-11-28" version="1">MKLVAVAVAFLAAAGFVAASPIPQDSNPINPTTTMKLFTAITALIATIGFASAAPAPNDHGASSIRPSVKENVILITYLELVEAAEAPHRAPYAQKAAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRX0</accession>
    <name>K1VRX0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000295">
        <property type="protein sequence ID" value="EKD02237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRX0"/>
    <dbReference type="HOGENOM" id="CLU_855780_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRX0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39441" checksum="5C9F99634880748C" modified="2012-11-28" version="1">MLAALYNSYPHIFNDIFDTFFHDADIKTLLRLRLTCRLLQHFVDDTWGHLRWQAGPTYQGLGRWPAASAVRDWRGHSLSTVSPFLSLTTVLDLNVSSTVLDEPCRGRVQDWRAFPASLKVQVLRMVRYDRWAMRFVRLPPARTVVIYHAVDVRHTMSSISYLPSVNVVWKLDYANLNPSMGTLCDNTGPCQRTNVFVLLSNCDPKDTHLGGLWQGMVETVAENVRYGKQTFFYLVDVQSWFARSDDDEIEPLVTIIPDEPEPEELRMDHILDDPDAFYDLISSIHEEYVRRSPLCGEDLVELVAAGCRCSSFIRRISTKEMRMRIGDKATSFALAPIGKTLHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSZ8</accession>
    <name>K1VSZ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000243">
        <property type="protein sequence ID" value="EKD03646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSZ8"/>
    <dbReference type="HOGENOM" id="CLU_630362_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSZ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="486" mass="53793" checksum="A196D718A83CEA5E" modified="2012-11-28" version="1">MPQQAPPIDARPFLSSSQKRELASIPEPYRRVGAWLILIRDDRSGEWEERNTKCIECTGQRVPCIDRVDPGTKRRRCESCFLGDMKCSPGYELQNPDAEGTPATGSTRTKKRKHEKEDRDTMVRKSVKQAQTSRRSPSTSSAGTMSSESIIDLTADEVRVINRVGEAKPQPAGRETSLIRQHARDAESTFDGSDSAGEESSGSGSESEGDPPQLRMPRQRLSPEERGKQAAPPFNPPQMNRTRSIRAPPQARSAYPPRVGSLNMEESAANTSAGSVLPAPAASSSSSVRLRFYRNDRIKSLLYKARQTMRPRIAVIVDMREGTFSKKKMEPYDFTIAVATPANARTSTWTVTVIDNRKRLGRVLFNASGPGDVAQANNEERELYVKFALEKAFETFSGLITLEALRYPCLKDLAGGSFYAATLAVACVRNLPSLPDRDFVINEDRALVEHSLLLDNVRNPPPSTTFGSASQVVARISRQDGQFRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT06</accession>
    <name>K1VT06_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05881</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT06"/>
    <dbReference type="FunCoup" id="K1VT06">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT06"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="InParanoid" id="K1VT06"/>
    <dbReference type="OMA" id="FARCDIQ"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="13"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="737"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121399" checksum="93E607E97003C6B9" modified="2012-11-28" version="1">MPAPAPTYAAPLANTRNVTIVAHVDHGKTSFADSLLSSNNIISTRLAGKLRFLDSREDEQERGITMESSAVSLRFDMMRPGPDGKRHVDFASEVSTASRLCDGALVLVDVWEGVCTQTIAVLRRAWIDRLRPLLVINKMDRLITELQLTPLEAYHHIARLIEQVNAVMGSFFASERMEDDLRWREAREKRLAERAEAAANGDLTDDAPEEEFEEREDEDIYFSPERGNVLFASAIDGWAFRLGKFARLYADKLGVKEANLRRALWGEWYLDPKTKRVVSRKGLNGRPLKPLFVQFVLENIWRVYDTVLEQHQYTPEATEKIVKALGVRVAPRELKSKDTRPLLTTIMQQWLPLSTATFQAVVDVIPAPDAAQAVRCPFMLHPEEAAASSTPLQPENNTEEALYKCDQSDAAPMVTYVSKMFAVRRSELPEHRPREMTAEEMRERGRIERERRAAAAAAGADKTAEELGRPLQELSLEESAPDHIAAQEEAKQDQDGEVLLGFARVFASTLRRGDEVTVTLPKYDASLGPNHKRNARWVRTARVGDLYMMMGRDLVSVDFVPAGHVCAVGGLEGVVHRAGTLNARTAEPVNLASVNMGGAPILRVAVEPVNPSEMPKLVAGLKVLNASDPCAEYLVQETGEHVILTAGELHLERCVRDLKERFAKCDLTVSEPIVPFRETAIKAPDMAPPKEGGARGTITSAIYDGLVEIQVRAVPLPENITEFLLAHQSTIASMFTKAKPDAGKKPKPSADGTDTPKSTAEEDDSDSEDEDEDATVEERNEETRSMPVDEFWTQLSALFDKAGPDWAGAADRIWAFGPRRVGANVLLDPVGSSNARLRKREALFAAARERGQSAAEALASAQAAGGAGGVEMVGDAEAEGKDEARMARDFDHSLEAGFQLANLQGPLCAEPVVGMAYIVEHVRYDPSKSTSTSSHAVIGSLISAARDAFRQGLLDWSPRLKLAMYACDVQASSDVLGKVYAVLNRRRGKITSEEMKSGTDFFTIRAEMPVVESFGFVDEIRKKTSGAAQPQLIFAGFREILGIDPFWVPTTQEELEDLGEIADRENPALAYMEQVRRRKGLEVRKRLVVSAEKQRTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT92</accession>
    <name>K1VT92_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT92"/>
    <dbReference type="STRING" id="1220162.K1VT92"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009438_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT92"/>
    <dbReference type="OMA" id="QHASMLK"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="790"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1058" mass="113336" checksum="6DD83950BE74AE76" modified="2012-11-28" version="1">MPERQNSSSQLLTPSPADGDPLSFSPGGGHGGHGGGHGGLTRRISASALDVTASGIDRRRPSLSPAVPSPAIASPVVASPSAPVSTRTSPTKTHATLTPRPKRPSLDPDLLGIGGSGGRKYSSRRVSGNTRPRVALGLEGMDADDVLETRYDEMGDAELQAVLDRWAVKPLNLGAGVADDSSPSSSSEIDMDVDVHETPRSDRRRPPLEATPSPQHAHTGSPLAPKLTRSSSSNQPLFPPSPPQAPKSSEHPLRVLSKAANAPLQAMASRPRSIKDSGERERSEAVSVPKSDQASIHDSLADALSTSLASPGKMQLMLDERPGSPSSFASARPKSPAPSVQSARSTSTSERPKSRESRPRTASNASHKTWGSIWGWGKRPRKGSMGSTTALPEEEDEAWRRGDGGSTPGFRAVVLATPKLAEWAHALVSNARDEDISVKEPPGRQRARSRAASVSSGPPALNEPEGGDVVSGAVAAGRSFISRSKAAMGMDDAAKPPKRPALLSKPSSRTPTTAVTPSSSEVNGPLPPPSVELASIVPDESRPPTVLLSRQNLGSFFTSSRKGAPRLSTATRFTSDQPPLTDRYGFIYDIQHASMLKDASRVGTSAPISLTGHNLEPPALSHDPATIPVSPRSASPELPQTPETTSPPNGSVTVQRRRKPSLYRSLAPAPSRPTTGKDEVSVAVRGGASRHSGSSASAALVSETGTPNSEGEGSASRLTVSSLLDQLTEIHDRQQKTRTAEWDAFLRKRVRRGKDVGVSGAISAIIHLQGSSSKSSQEEYNKFLRLVRRGIPIEYRSDVWAESCGARDSMVPGEYAEILSVHKEDQSAVMVDIDKDVGRTFPGNVFFGGDGPGVKKLRRVLVAYSWHNPAVGYVSGSADETEQAFWVLDSMIDRLLPTDYYAPSLLGSRANQLVLQDLVQLHIPKIWTHLQNLSIDLTSITFGWFLSLFTDILPVETLFRVWDIFFLPAEQGEGGNAILFRIALAILKINEQDLLRSASVPAVFEYLSGIKLSSKLWNPDKLIALQHSYKGVIKGNEIRKRVEDKIDQLQRELDQDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTG7</accession>
    <name>K1VTG7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTG7"/>
    <dbReference type="HOGENOM" id="CLU_1001787_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTG7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="278" mass="29905" checksum="61023C3DD93736B4" modified="2012-11-28" version="1">MVYNLVFCSISFLHASPTLSPPALRSSTPTSRRALVLDLVPSCQAVASPIGAFSHPSPVRSPARSGSLLPVNRSFRLLLASPASRTATPCARSPASFQSGSVLAVPRVDLSLFVYFSRPPPAALPPRARARLPLSQSGSVLAVTHSFCLSTSRTATRSIMRCALGPLRRLSTASASAPLRGSRLGPGRSQRPALRFTSSELSFILVGLSALGSFKVYLSSRVEAQLARDVDGLGHRMDLHQVKLDDLARDVAGFNNRMDVLQGKLEELAHSRPHYRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU25</accession>
    <name>K1VU25_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_05536</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU25"/>
    <dbReference type="FunCoup" id="K1VU25">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU25"/>
    <dbReference type="eggNOG" id="KOG2472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="InParanoid" id="K1VU25"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="368"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD00193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="693" mass="76708" checksum="E45FDBE78A344997" modified="2012-11-28" version="1">MLPPPGETPHRRHVATTHGAKLESASEMSTRTRWTQQAGPAIDFVITTTERFTTAPRRLDLIEVTTENGEYTARAAALFLLELAKQTFPRTALLTIAADYHCRQGRALSPPRAGVLSLTSSASTSTTEEVEAARKAGLPTPPPQLKIEIPANRYDLLCLEGLARSLRIFLEKETAPTYTLAQPAKLQELIIEPSTSPLRPMAAGAVIRLARPMNDMEYASFIDLQDKLHQNLCRMRKYMCKDPNEIKFAPLNRETEHTAAELMTIYEQDRHLSKYLGIIRDAPAYPIIYDKNGQVLSMPPIINSDHSKIVAGKTTNIFVDTTATDQTKLDIVVMLVATMFAEYCKVPFEIEPVRVVMPDGTSRLTPDVSPRLTQASLEYLNAATGLELSREEACRLLTKMSLSATPSTTDPDALDVAVPCTRSDILHECDIMEDLAIAYGYNNLPTGTAKSSTVAKPNPVNKLGDILRREAAMAGWTEALPYILCSYDENYTWLLRKDPGGEAVRLANPKTVEFQVVRTTLLPGLLKTVRENKSLPLPLKVFEVSDICKQDMKEDRKARNARHMAAVYTDNRAGFEVVHGLLDRIMQILAVPFIESAKSDKEFGYYIAEGSNPSFMPGRAADVYLRPKPGKSTRTQDKTGVLENMTDALKNALPGHGRDICIGNIGVLHPLVLQNFDLTRPASALEISVEHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUJ6</accession>
    <name>K1VUJ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUJ6"/>
    <dbReference type="STRING" id="1220162.K1VUJ6"/>
    <dbReference type="eggNOG" id="KOG1492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534409_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUJ6"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="570" mass="62379" checksum="24A5A8A24935EE4F" modified="2012-11-28" version="1">MRQVVNGWTTSTRQPPPPINRLRNHYAGWQSQTLDKIYQNTRGYSAAVGGEGSGQPRVLIRLLHRNLDVILVISSIISAMPPLTATERQKLLLQQEIAKLSAAPAAAILPLTTPTEEVTRTAVVVASQPRVRVLNTLVVDTSANDVSRYELGCGGGYGNGGRRSFPNFCADDRAFNYPEATIRLNDKLAAQPPRPRQPKVPPSIQVLQSSSDTSPGGSEGQKRVVIDGVVFQFEQDGKKLTRIGGTLHPLSATDSTLDLPGTKKDVNNTPTRHSLKYQGENFRRTKRGNLISRSTCGTIPGQRAVTDHSRASARRAEQAKRPCRYYTKTGRCERALTCPYQHIPDRLAICHQFLKGTCQLGDNCPLSHTPSAHNTPSCSRFQATSSCYKGDKCIYPHVRVADDAPVCEAFAREGWCDKPAGTCPELHFWECPEWHAKGTCSRGRKCGLRHVLRAEKTKTKGAPAPEPPTAAAAAEGGFDDQAEFIGLPGEVFSETESEEEDDSDEEEVEGSDEEEDDEDGSAEEEDDEEEDDDDGDNSIEVDDDSGKHEAASPTEVASDEDDERLVLDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUP8</accession>
    <name>K1VUP8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUP8"/>
    <dbReference type="STRING" id="1220162.K1VUP8"/>
    <dbReference type="eggNOG" id="ENOG502S8WT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585281_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUP8"/>
    <dbReference type="OMA" id="RRWENAQ"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="495" mass="53301" checksum="70FD170970B69AFE" modified="2012-11-28" version="1">MFNESDVRANLAESAVFLVRFAPSLLTQRSQLTAIMTTNDSATSAPLRLPAILQNPKNHALRQVEAHNQQQREKAAARREAAKNRGDDVAASSSTRGKRVVRRMNNAAFVDNPYAVAPRRSDMSPSVPLHQRPLKPSFPSDAIERTAQIPSVPGTKDPLGASSVSGAFPTSLKGTRALLRKRGRRAETIVPSIENAVRGWLGGEYDIAPGDLGWRVIDKTPVEASARAANGHAGPSNGRRLPPQHQMNALPPLPVENGSVPAILEVSRSVAHLSWAVPDSFDRLVVHLVARYYELVSWNQSTINGQTVRLTHLVRPNLVKARAPPPSHALLTPETTDVSGPSAGETSGSGTEGEDSDAATEMGQHSDVEEDADKTFTSLTERFGTESDSEDQLTDLGLTHDALMERFGNMDLHRTVSHGSSAYASSEGGFSEFSVPEAHGISTGWHGSTGSESVASSPIVSNVRLPPTRNGPPQRLGGNSDWSDRPTFFEYLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVI7</accession>
    <name>K1VVI7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_05015</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVI7"/>
    <dbReference type="STRING" id="1220162.K1VVI7"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_3_3_1"/>
    <dbReference type="InParanoid" id="K1VVI7"/>
    <dbReference type="OMA" id="VHLFEDC"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF17">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD00823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="152" mass="16603" checksum="E289035E8321DA9D" modified="2012-11-28" version="1">MARTIANPAGVPGAVINRNTARSSTGQGLGKDVRRSGLGSGAAAPQKKRRYRPGTLALQEIRKYQKSTDLLIAKLPFSRVVREVALNLTSRRAGELRWQSSAILALQEATEAFLVHLFEDSNLCAIHAKRVTLMTKDMQLARRLRGPWGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVL8</accession>
    <name>K1VVL8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVL8"/>
    <dbReference type="STRING" id="1220162.K1VVL8"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_1_1_1"/>
    <dbReference type="InParanoid" id="K1VVL8"/>
    <dbReference type="OMA" id="GIAEWLF"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="227"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="658" mass="73480" checksum="D453BFF8A4977700" modified="2012-11-28" version="1">MEAIEKMSSDVGVGAVTPHAQLVARHVPRAWSGEISVAVFLGAGLPPHDRVHRHQARTDSRRDTHASNSDSRLYFRSASPPLSFAFANQNGRQLDMILRPFLALAAAALAPLSLASEKVNDVKERRAHGEIGMLRLKLTSGGHCRAFAPTWERLVEENSHLENFGFHMAQVNCLAQGDLCTKNNVKGYPQIHLYVDGEDQGEFPPEKRYYDLLTTYISEEADKYAKSLKLDTGDDGGASTPNADGQVKEVDDDGLEKLREEGPVLLTASCKSFAPTYKSLAAEMKGEINIASVNCDDHRDACRRHDIQGYPTVKLLQGGKRGTSLEYSGSRSVPKLKKFLNENVNSSTMTKINADMFNSTLAENDVFFLFLQSFVTTKDQVRSVKDAVASLPANVSVFTSNDPALYRDLSVAQPYPESALLAFAGHDRRPVASMPLPTNQDKLDRFVFENQFPLTYDVTESMYLDVLKNKEFRPIVVMAAFKQDATKGESEAELRKIARAWRKMPRTFDQPVWFASVNGDKWAKWLKRNYGMTPADMPSVVILDSKKDEYYDTTLEGERVRLDGAAIFSVLEGVYQKFLKPKKPESRFAWGTAGIRAGFLDIVVWMAENPIKGFFLALFVLMGSMSLVGRCFQRDRSGFGGYMNEKGYKRGSNHERLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVR5</accession>
    <name>K1VVR5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab family GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVR5"/>
    <dbReference type="STRING" id="1220162.K1VVR5"/>
    <dbReference type="eggNOG" id="KOG0088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333995_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVR5"/>
    <dbReference type="OMA" id="IYTSSAM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="784" mass="83828" checksum="64CC00484C9D6F45" modified="2012-11-28" version="1">MRSPPGPSKTTVDVLGPPSPSPAYMPRGVLLEPDVRKSVLPPTPDPSPPARLFPTAMVALAPPADDNSNDSSAIYTSSAMESSASSSSSSHSTNESRSPGLIDANSNSSVQLQRSPSPRKPARRGMSRSETAPNLAPGSNRNSFSRVKSYDTKEREREQRDRDRRNLGRRQTTAGHPGQPTSVRMVESRSADSRTRLRSTGGPKLTRYPTLATEYPSARLRRTVTHDNSSPSTPPPSAASARPHSHHLTLAEPEQLDFGGPNGLEAKLVLLGSQGVGKTSLILRLTTGTFNAERASASVEGSVYKRKLEHNGHPIKLQIWDTAGQERFRSMAPIYYRGAHVCILVYDISDRKSFQDVQSWLDELNHKASKDMMIYVVGAKLDLGSQRAVTLSEASRTIRRWLNPAPEPEPEPEEVLAPTRSLFRSTSTTRPRSDSMSLPSPQRRPHSMHGLASLMLAATDFDFDLSASTSGSGSQAPTLVAPSPAPTVHFPPSLVTPTSIPGVPTSASSTASVAGSVGSPPSTGMYRRQQRVSFHGPALAEPTSATTAETAVASTANGSKHRLSTSRFSLSGMLGLARSPTSDAVANLSHLADANPVVSPRSPRPSLSPGVRVRTESSPLLDGKRRSEDWSATGPGWGRGEGPSAADALEEFGAAAASATTWQSQSAQSSPWAISPAPSSLPVPRTRLRGGSLGRDTRLFEDESSDDEPDDTWGIDIGSVRVGEVSSLTGEGVESLLRSISAQLIERKDKIEREHTLRRKNSVMLTDPAKDKRPAKKGGFSCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW21</accession>
    <name>K1VW21_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW21"/>
    <dbReference type="STRING" id="1220162.K1VW21"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_928084_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW21"/>
    <dbReference type="OMA" id="ENIMHAD"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000137">
        <property type="entry name" value="DNA polymerase epsilon p12 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="300" mass="33340" checksum="B7580141BC96D6A0" modified="2012-11-28" version="1">MEVEYEQPPEHAEQRHEEESHHSDGEGAEGVEPAAGGEGEAPKKKRVIKSRQSLAEKQPGTTIFPMARLKKIVKADKDLDMMTTEAVFLVGVATEYFIKHFMEEGYTKARLEKRRIVNYRDMANVVARSDEFGFLSDVIPQPMSMSEALELKKKKMSEAPGSGAESSEEEEEDSEDEDGEPKEKGPVNKGHGELPPLTSSTNPAFPNAIMKKPSNTHARHAMPKPGDEEKEKDAEKEKEKESQRVKPTSPKVPLSGKNAPSTPTGLTTRSRRSLAAESEPEPREDEEDDDEVDEKMAVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW89</accession>
    <name>K1VW89_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0585 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW89"/>
    <dbReference type="eggNOG" id="ENOG502QVX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1267688_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW89"/>
    <dbReference type="OMA" id="LHTTHIE"/>
    <dbReference type="OrthoDB" id="10258744at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974:SF0">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24291" checksum="6A9BB496CAC4E402" modified="2012-11-28" version="1">MAYPSIISQPARNLQPVLEALSPLIEGSNAKRVLELASYPYEHIRGYAQKWSDVQFTGTVRDDKEINTTNTTDLPSNVGRPLRLDIAEEGDWAALTDATAEPYDGVVMLNLVHCTPEGLPENIFRNLSPKLKTGRRVLAPGGWVAAYGAYLNDDGSFRSPADAKFDAEYIKGMHPSLGLRTPKSITAMAETWGFREVERKDMPKGNLWIVWKVEEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWK6</accession>
    <name>K1VWK6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_01860</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VWK6">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWK6"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_2_6_1"/>
    <dbReference type="InParanoid" id="K1VWK6"/>
    <dbReference type="OMA" id="NWLDESN"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="1225"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="1826"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="2129"/>
            <end position="2161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD03847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2161" mass="242812" checksum="07B325BAD0410B22" modified="2012-11-28" version="1">MTNPAPPEADEKLLAELFTHGLASVDVAETDPEATEEAIKRYRKLLRVLVDYCVLRPLSDKTRTEPLEEKVLEQARLSLNVVARHSAACPDVLLFESDDIDTPGPFYAWLITRILTAAVGYEDLPGGEPLVKELEKCIDHVFLVLERDLGDSASSMIGPHRVTKIMNEMVSESTLFGFSDLPSDIATNIFLLNSVLRSTAPFAAAARLGAATVLSSLHSKLHQTSPHRQALYASVIEAALGGSEVRHVLSRAVTTIIELPEDGERLESAIVSLLKAVEESGDSSLRRDVWWALRESGVDTIALDSKVTQQKVLFLLGPIANHVHEGGIEAALEREVLEHWTQQATSRNLLDVRERLKRFMKVPPPVSLKRKRDDNSVEASVMAILKGKMPDLRLDSDLLDSFPGILEKSAAQTLSQSWAQILWRSGKAMSSPERRTRIAAGYASLIVHVADVRTLVSAIYKELVSSDQPQYKSLIQREIIGRFPTLLKGPLRVQETALNLLGDLGRGSPDRELGDILEILIRQLGSTSTIIRSIAYTQLVGIASFRRKQPYNLISPYMERISVLLAECIVPQPMVVAEMMQFIGYNRATFFALDAARKAVIPTLILLQNRPALEALESILNQRLGVLIVEEGADVLAKIFLTPERTQSSLSFVTTLLGEATNNKSPPQAILSKYIQASIVPLLVKIVVELGDKDKARRDVADRALNALQAAEKKQCDDLGSYLKPHMLGVLASLTENLMTPRTPIEHRIKTICSIGFLIELVGDSMASFSPQIIASLQSTLEIPGLRLPTLQTWCKYVELLRFTAVGPYIGATIAAIVANWSNLDPAEREQAKLIVGHIAGNATHLAEFRDDIIRFGHIEELANYNRILLDYRKSWSITEQLEKLIERTDSKNIAIATESMRELRNLLKERHSDVMQLAQGDAFEPVLGQTVRSLLAAATRSADCEELRDLAYECFGVIGALDPDRFATGGEEKSILIESNFTEAEESVDFALNLIKDLLADAFRSTNDPKHQNHLAFAIQELMRFCGFDSRLVKGGNVPSKVQRRWKKLPEDVLKTVNPLLDAQFKQNQIKTRTFEYPIYSTKKTYREWIQVWTVDLIGRVMEVKHEGETNHAQKIFGVFLSEPKNQDVAVAHHLLPHLVLHVLLSGNAIAREQIREEIWDVLRDQVSPAPGSTPEKRMLSAQVIFQLMDHLSRSLRQSRDSDKERRSAVYAVDQLISSIDKELMANAAMKSRAYARSLRSFEERVIHLRTREHKANKDLQTYFESLHEIYAELDEPDGMEGVSAFVVAPSLELQIREHESTGRWTSAQSCWEVRLQQSPEDLKLHVGLLKCLKNLGHYGVLRDHPDWAEELAPFRAEAALAIGDWATVKDMANPPPIAKAFLAIGEGASAVPEAVKIARREIGSGITTRDYGRAYDTILQLHMLREAEMIHNTDLMITHPNSEVTTNGTVIARRQAASLVSSLAQRFETSLPSFRAREEILSKRRTAFRLVKSQRLQGELGQAWIQSAKIARKAGYEQTAYSAALQAERAEAPFAFIQRAKVTRMQGGILKALREIEHPVQDLVIRSENADSVIDLTLDSGDSKKTQEDFRRERNLAKAVLLEARWQNEADRFEQNGVIRRFKKATQLGENLEAPFFHLGRYYDTLAGSTSNVEDIKTIEKMVVDITKLMDRSRGKVMSYQYLTAFPQMISRITHGNKEVQEVLVKLIYRVIRDYPAQSLWPAVGAIQSRNKQRRDIMDQALKKAIELRDRLNDARRLSDILLRLAEDKPVAKVRQVSLSKQYPYVREAFPSRMILPMQDVLTVLLPATGASIKGHNPFPQTAVTIEVEIMPSLQMPKKLVFKGSDGKRYPFLCKPHDDLRKDARLMDFDAMINKFLKSGSEARRRHLYIRTYAVMPLNEECGLLEWVTNTNALNSILEKGYARYGKKVYTSEIYNSLDQARKGGNPIRDVPMVFRDKILPMFRPTVFHEWFLLAWPEPTAWLTARTNYARTLAVMSMIGYVLGLGDRHGENILFDGLTGDTVHVDLNCLFDRAKTFEVPERVPFRLTHNMVDALGVTGVEGSFRKAAEITMGILRQNGDSLMSVLEAFIHDPLVEWTKKKQQDVRTVSDKSLKPIHKKLRGVSGDTIQSVPNQVESLIKQATSDTNLGLMYVGWKPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWP7</accession>
    <name>K1VWP7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWP7"/>
    <dbReference type="HOGENOM" id="CLU_1099154_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWP7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28467" checksum="EAC37D0AD1F4E5C8" modified="2012-11-28" version="1">MPPIRTKRERTSSVQPVNIDPQWSDGDFSLISKDGTTFKVPSYHLQSASDMLLAGDGPKEVTLEARAVTIGHFLQMVRSGKPTFTEIEDFEYMDQVVELAAFLDKYQCDAALYMFFHFIRTIEPVAPLLLFMVGVRLQRPRVCSEALDQSPQSWQSYCRKAYSRDGFWKTPKFVQDFQKIKQTPPAPVALDSQMLLPQAIPCSLFLSLPPEYAWALAAGAFYHNNVAQQCSGAEFLMLVKVAQEARALAEDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWV6</accession>
    <name>K1VWV6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWV6"/>
    <dbReference type="STRING" id="1220162.K1VWV6"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279799_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWV6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="896"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="945"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1125" mass="120905" checksum="E8C5016728BC457E" modified="2012-11-28" version="1">MDSGATPGPGARRSNPMRLSVDTTASASGSAFRNRVLPVLPASAPGGSCPGAARTLSAATAEAPHAASHQFQEDVDSFPLPPEMLKAWTDLEGAEGINGPPYVTLDAPEAELLGYPTPTSAVSATQEYKFDPDDVDALALKSLQANNAAADPPALISTVSTPDDKSPALHTPPSDLAPSCHPPLSTLDSEGALISNPVDHTFVAPAATPQGQGRRSFNQHPCGGACIASADPLEPGSASPQSLGDAASRIATPTTIDTDQPAGALSIPRAAAATVVSTSKGGLSAPLPLESASANATIQLNRGSTVHDKQAGGLSPRSGHLAEQSLETLTPTPSRIMNTRTFPTVSQSPSPAPVQWSEDVCRSSSAPPQIGATATDSAELAAFGVPSRPKSCSGNPPANLALTPVDYVAARDSRSSQSPTTSPVSPTYDGPAHGPEYTGEPVQQLPAVDGLTLQPTLKDVDETMECQITGAVPPLPTPDAGSSAEQPLSPNRPQLKWWQSGPSPYQHRPLTLVNVTGSGGLPKSAVTGYVAGEDHAPVAPVEDDEELSELDSASEAGASEVASTPYLSAVSTPADTPAAQQEPPSPTKPLPAHKLKSKGNARQLIDLQTYSTSILGGQTMMSAKRTRKRESSDTVCLTLNPHLTRQTASVINSPQPYLPPPPKRQKAGSAAGDKACNQDQAATASTTKRKKKQSASDDDPPQAAQKRQRQNAKQSGAYFSRRRWNDCSESTSSYSFPASTLEHITFALEARREFFGDGIFNNDKSVLCRAALIKAGFSRSAGAILTRGVPILSFLPLTLTLTRFSTMVLVDDFTCGTCLKQFPSGWRARDKHCAALGHSRPTFECETCPRYFKTDAARWQHMDACNHFSIECDMCDETWPTMDMLREHERDDHDYWHCEECGDGFYAEWELQEHREDEHLRECQWCDMFFEFDSQLEDHEEHAHHYCHACERLFNSAHSLEQHRRSRAHLGTPIKCPFCSAGYATATGVVHHVERGSCPNARNVDRRAIFQMMKQRDPNGYVTKLLLEYDTTKYTSTKGGWNGQAWECSLCYREFGTQRALDQHLASPAHAQNLYHCPNRSCRKDFSTLAAAVNHLESEGCGYMNFHQVQNTMGTLIGSNRLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX70</accession>
    <name>K1VX70_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX70"/>
    <dbReference type="eggNOG" id="ENOG502RBGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738076_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX70"/>
    <dbReference type="OrthoDB" id="2591246at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="375" mass="41507" checksum="0DAA466DCAA4D84F" modified="2012-11-28" version="1">MPEARAPRGPSDPADAICSLMLTPHLSRDTAQTEYAALIRTRRDHHRTKGCSSEISDSRTSPTRPNYFKTMLALGVGPSRLALRRLATSSRPILLARGPAPSPASLVGLRLLSTTSPVNATPRRPVKQRPVRNQLTEAEWPWRSLGNGEEERVIFARPVSTDPRMMWVFAVLWLGGVVTWIVMPSDRETSAYIAKQFPDAPKAPEWSFLGIPQDMLRTWVLSGAITATTIMGLGAALLGSRLVTRLSLIRKVGETSSNTIRMRTMGQEMIRGAGKGGRDIPRSECSTNLVLGRPLTSGIRERTSWLSLWVNSPGSASRLNKDHYSYRMDFKDSARLDRLTESGAEVVLSVRRVEDVFGTLEPRDKVIQAEPKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYC8</accession>
    <name>K1VYC8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYC8"/>
    <dbReference type="FunCoup" id="K1VYC8">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYC8"/>
    <dbReference type="eggNOG" id="KOG3979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYC8"/>
    <dbReference type="OMA" id="HIGEMDI"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000100">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="48"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="5">
        <location>
            <begin position="422"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="4">
        <location>
            <begin position="509"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="6">
        <location>
            <begin position="741"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115408" checksum="471C32BE8DF388D5" modified="2012-11-28" version="1">MGPAETSRGVQNELRRKHSGSRIDTQAARLGVADSAGGASSNNGPRGSYIGDHAAARAPFQILIALTATPRFIFLGLQWLAHRYPPSSSFPSSRPLSAPLSSPSITSTHDTEHKRSLRSRSRLTVEKGEKGSDDELDSDVALDPPTNGTGRKKAPWSSGSVDVEACLGLARTIACGGWMFITSRDEHDLHDLAMIVYLVLDAPWMYLSWAHSTDPRAKKWRAMCAAAFFGCLPPLIYLFVQHNIKKVPGAYTYYAFFEWSLVMWDVAFDAGTVFEVGNFQIRVIDTSRPEVEDDKNGHASPVGIYLAPVPSRPIVEEDWTAKPSRPSPIPHPGIAAYLSDIWFGKLALFLLVANDSDGVVDRLHGRQRAALLLVRVVPGADGLRAGHHDQPHPVPLQQARVPRGGDVPLRCILEPHAATRTRGSPEAGQTGRMWAAGVVLCMLGKYLCYSNNPFWAIVNSDSGGWNKTGLLLSALSVAELYFRPNSLFAAPLTTAPGKRDDRRMGTTRAQRLAITFGLGAFMHLAQTFLSDSGTIIAWSWDGFPARAPLLHPWAGIVTALCALAIPLSLSIQRLLDPVVLAVPYLGAFCLYMFPNWVGFAGGVALMVWLIAAAPAFIRIASGVPPKTTGNAMAWNCFLDVASVFTVAYAFVPFGWVLRERTGFILLLLLVPLPFALRAGQALNLPDESRLAARSRKRLQTGAVYTRYLSIAIASAAIVAGIRLHAQSAEVTTPKPYYGDLNVFTGGIYTVHFGIDEPGRDSQRRIASLVKDMEVDVLGMLETDLHRFVYGNRDLTRYIAQELGYYVDLGPGPNKHTWGACLLSKYPIKNSTHHLLPSPHGELAPAIHATLDINGVDVDVIVSHNGQEEDALDRELQTKELARLLQLNPHRPTMFLGYLVTKLNAPAPWPYALLFNEQTRLSDIETLDKWRWCEYLGFRGLWRVAYARLHHGDVTDTELQVGKFILPLPNQTAEYRNDEEKYWHIGEMDIPPPWRLPSKFREDQGGHFYRVWDGPLYYRPPLDSGVLDYGRGGGHNEWPPRTDVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYF9</accession>
    <name>K1VYF9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Capsular associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYF9"/>
    <dbReference type="STRING" id="1220162.K1VYF9"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_4_0_1"/>
    <dbReference type="InParanoid" id="K1VYF9"/>
    <dbReference type="OMA" id="SDKIFWR"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="4">
        <location>
            <begin position="297"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="639" mass="73216" checksum="A5B9FD68E15B7DCF" modified="2012-11-28" version="1">MRQFKSLSPRGRVAAVAGGFVALIVLLHVLFPSSLSTTRRWTTASSSVLRSTFLRGKANAPHPPIQHPIPKLMADAQEAFERKVKSQSKTLREAVAEYRRRYKRDPPKGFDDWWEFAKEHKAIMVDEYDQLVNDLEPFWRFTGAEIRQRCIDVGYLPSVDLVRIENGTTRLIDVSKGFVDSEVGARAVGFSTMLAKFQNKLPNMDFPINEKAEGRILVPWEEQRYHNLTADTSKGIKHVLGGDFIPDWRADGSVWEAYRRTCDPTSQARRLFSSLHAHLKESQVPISRLAKAGVSTDVVDDDFIFAKDVDDKFDFCDRPWAHYNQGHFFSDWRTIHALYPMFSPAKGSGFGDILIPSHYYYFPTKLYAYGWWWLHEPKDVDDMEVPWEEKSDDIFWRGATTGGGSSPPGYLPQYQRHRLIKMASDHSNTNKTIVFADPPGTDNFISAPVPLAELNKEIMDVAFTRAVGCVQYPGGCDRMRKDHRFADAVPLGENWSHKYLIDLDGMGYSARFPALLKSKSAVMKTTVYTEYMSEWIQPWLHYIPVSQAYNEIYNIYAYFSGATPSMLNAANATRDQFQSAGHHTHKLDTDAELRKIAEAGREWMFKIGRKLDMEIYLYRLCLEWARLNADDREAMSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYG6</accession>
    <name>K1VYG6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYG6"/>
    <dbReference type="FunCoup" id="K1VYG6">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYG6"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_1_1"/>
    <dbReference type="InParanoid" id="K1VYG6"/>
    <dbReference type="OMA" id="PTRICTF"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852160" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="303" mass="33405" checksum="D8AFA074D39D8319" modified="2012-11-28" version="1">MARLSLLPFFAVILTLAFFLVPVQAAKGPIITNKVYFDIEHGGKPMGRVVMGLYGKTTPKTAENFRALATGKKADGTDLGFGYKGSSFHRVIKDFMIQGGDFTSGDGRGGKSIYGNKFADENFKLKHTGPGVLSMANAGKDTNGSQFFICTVKTSWLDGRHVVFGHVLEGMDVVHAIENVKKGSGDRPVEPVTIADSGELEIEHEIDDNGNQPDYEGDVEVEAINAIDKEILEGTHDTPVELDSEEDKEDYSTLSNPWKYLAFLVLFVVAPVGAYVYFYRGGREKLRRKIENWGHYEKLPTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ40</accession>
    <name>K1VZ40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ40"/>
    <dbReference type="FunCoup" id="K1VZ40">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZ40"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001040_1_0_1"/>
    <dbReference type="InParanoid" id="K1VZ40"/>
    <dbReference type="OMA" id="SIRQMWE"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1040"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133973" checksum="7831FC8E1C8E5667" modified="2012-11-28" version="1">MAASIKNHRGSDNNSMTTADQVQPYIDELSSNPEASPGRLLGMAVRVASVPIIQQVLASPNVPSPNLPVGPNTTATALHVAAEIGRPEAGELISACGEADFPVELLLNDPRIDDTIKDDRGRSPLECASNSEVAGLIEDSRAALQVRYMSLLAAYVASPLSSAEEANNIVKFLDQPRAENVNLNALDDRTGTSLLHEAARRRDLRLVEMAVKRGADVFVRDRRGRRALEGDKGADERIRAYLKQFSNQETIVQLKSDGRPPDLKGFLSKWVNYRQGWKTRWFVLENGVLSYYRNREDEQIACRGSIALATAYLSPSQDGTRFEVSSAVTTSVPKILVKSSLRGEIARWIQAIRLNIEFYQKGRKQLKPAISDRSDARSVYAASVAPSAAPTSDRALGSTLSDLPPTDQFLHPSLNRSATVMSRLSGKSEKGSRRSRIKNKFTRSKQPREADGNTTGSDEVLDADSSTGGDDDEAQDDGTLPHESEFELSMLNLKAQLELTGQLVDSIVTPPSTPDVTASAAASRQSQVKQTLRESLNIVNQLVSNRHAMTLDRERYLINRIKREVQARKLWEENLLAVAQQQAETDRQLQEAAKDNEKKRRALKQARTALADLTSQPGSPLPDAGFVDSPMSEHGAGPLGEGTKSPTNVEFGVLPATVRSAAGNRTSSISMRNSMSRQSRRSLSIQELHDAVASVDDSDDDDDEFFDAIESGTIPNLRAYDSIVDPAAREVSTPEPSPSTSAAVAPENGGAVVKKPHTITEYLARPSLEPYNHVRSKLPIDDDKRPSVSLWSILKSSIGKDLTKISFPVSFNECTSMLQRMEEDMEFDTCLTVASKEEDSLKRIAFVAAFAMSNYSSTIGRIAKPFNPMLNETFEYAIPNRYRYVSEQVSHHPPISACYCEAPTWKYYGEVDAKNNFAGLYFEIRPTGVAHAELIIPKEFVKPGLEYPPAGPEYPEGYVVEHYSWKKVVTNVSNFIMGNPLIDHYGDLVVTNHRTGETCTLTFKPRGRRGATAFQIKGRVDDAHGKEQWEIAGPHCSPRGCRLKASRGDAGGRRRRGRVHASVEEHEEAQGAVQPDAVRHHAQRYSAGPGAVPLPDRLSSAYRPARVRECRVRPRPNVSFLFLCLELTDRLKSANEEKQRETRRLRAEGKLPPHEPRWFTAVTEPDTSERLWEPKRADDGEVKFWAEREEQGQKPPEARWADVDHIFADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ70</accession>
    <name>K1VZ70_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ70"/>
    <dbReference type="HOGENOM" id="CLU_479129_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ70"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="569" mass="64747" checksum="1FEC1A48F48C7997" modified="2012-11-28" version="1">MRSKDGKIKALSNIPYHASPHVLIVTETGQRPTKPPPSPTTIAECDQLYRWCSEAFIEACRSAFKMPRTGEPVNSGLQRVRTISAARNNRLLALCRKEDEFHELRQIYKPEEFGVSWTMDETDEAAAWDKAIDGGKLKDLFEPANISNPPFLLRRGDSGPTLEHKPKEKLAIWTERFRERLQHTPPPVVEKQWLRTSRPLNNQSADNGGMTFHWPQQVSVSGLRHLLRKGNPRPCPTPDGWENWAWHTPPSIDRSDATAFEDALTYFEFPANVIEFETARIGECSMRVKSQDGLADVTITTNGQTKQGDAPSSLRYAFSMSVLYWWWSRVPAINQHFVRLRSLSKKIGRPHTKWDTVEQIIRLIEATDDSLLGAKSWKSLEKLTDLAEQFQSAYSIETNWENENKTSKVLKLRNGTWSDTPIQLSVFGLSKFHRNTAIEQVTRRLENLMPGATTHDDLRVSACNTSNTGFVKFARVSWKPRAWYRDTNLVAEMDRVRRLMNSCDLDLTACWSTSAGDDRRTVGQFKLEQSFSTVTITAAQATASVEKFCEENGHKLLRVTAFSFGKDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZA0</accession>
    <name>K1VZA0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZA0"/>
    <dbReference type="STRING" id="1220162.K1VZA0"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="InParanoid" id="K1VZA0"/>
    <dbReference type="OMA" id="DLHPYHS"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="192"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="37914" checksum="343AE36D0C3F3F28" modified="2012-11-28" version="1">MTVDLPKTMKAVVLEAPYKVAVKEVPTPEIKEDNDVIVKTKLAGLCAEQACWNREASPPSPPPPPSAPAPASLTAGSDLHIYRGHQPGCDGITIGHEILGTVVQVGKGVKSFKPGAEYVRIPEGEASLYHAPPEVPEKLMLLMADIIPTGYYVAYQARHGMDDGQIPSQSLDGTVVQPEGKKGVCVVVGCGPVGLCAITCAKTMFETVFATDLAPHRLEAARKHGAIALPPSELKEAVLKATEGRGADAACEVVGHQSALDTAIDAVRPYGTVASCGLHTHDVTVPGLTLYGKNLKLIFGRCAVRTYTPAAMQVLKDNVDLFESFVEHEVSVDKAPEYYEMFEKNKIAKTAFVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZV0</accession>
    <name>K1VZV0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZV0"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_9_12_1"/>
    <dbReference type="InParanoid" id="K1VZV0"/>
    <dbReference type="OMA" id="MIRASAH"/>
    <dbReference type="OrthoDB" id="3262968at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="291"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="897"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1322" mass="150570" checksum="FDD22F0A6E06E80A" modified="2012-11-28" version="1">MVDSLGSVDIPISFGAPDARRPRDSYKIRFHVVSDLPKGLLIGMNAIIAMRMSLFPHLGKIEIDGRSYKARSTRPRCPDPMNGDHSREVRLRETFTLRKVGPINVPAMMDPVRTNLDMIIDPVDIGNGSKLVRGPRAVVQGGKDSFQYQLFNATNRPIRLPRGTLLGIARPVKPEQITPMDRVDEIINKLEAEEKAIEQQLPLCAVAEYLGGGMPEELCEEDNKEYMKLLEDITINPDLTTEQRQQVEHLLKIKMKAFASARNPMGKTDLVEFDIDTGDAKPVHMPPYRASPARRKIIKEQIEMLREAKIIQPSNSEWSAPVIVVEQHGKHRMCIDLRALNRVTIGDSYPVPRVLDILESLEGAQWFSSFDLNKGYFQIPNTKRARRRLAFRTQDGLWEPLRMPFGAKGAPATFQRLMDLLLAEGRWLWAMAYIDDIIVYSKSFDEHLKHVSWTLQRMIDGGLTLGANKSHMFMKTVELLGHKVSNIGIMMGDKAVEAIKSQKRPTTVKELSRFLGLVSHWRRFVKNFARVSAPLRDVKRAAANLKQTDLDWTPEAEAAFTHLIDALTSDVLLAHPDYSKPFIIECDASQDGFGAVLSQRDENGYVRPIAFISRQTIAGEKNMSATDLECSGVMWALDKLRPYVEGSDIELRCDHEALKGLADYKGQNRRMIRASAHLMSYLSDIKFIYRPGEKMAHVDQLSRNPQPLTPEQIRNLQEACEVYLAGRLEEQKAEEDHDDPNDVAESLMCWTIEPDTTFKDKIMAVSELDETYTELVDEILIRYDIPDSKPYDRTVWRQVMHHPRKPFMINDGLLYTSSQARNTHTIVVPTDETLRTDILKLYHDTTLAGHRGADKTYAALVDHYYWKGMLRDVKQYVRTCEKCQRSKPDNALPPGLLKSLPLTKRRWNMIQVDWVVGLPESGPQKFTAVMVVIDRMSKRIVLTPTHDTLNASSIVQLMFDNVFKYFGLPSCIISDRDSRLTSDLWRSLMKYLGVQHRYATASHQQTDGATERVIRWLKEALRSYVNKEASNWSSFVSRLEVAHNASVQASTGMTPFELDLGRIPFFLHGPSKPDLAGDPDATRLRQKMELDAIIALDLLDKAQRAQKSQYDARHREVTYKVGDLVLIQSDVYSPQEGVRRRKRGAEQRGRKLGPTFWGPFKITDIPHDNVAQLELAPGMRAHNKISFAYLRKYHPRAPDPTAVRTFDCVVDAKTVHNGEVRWRVRFKPMMWQGQEITPADEWVDETTLKFFGGGAIAEEHREECERRSGAYLAYKLYTFNTLDDSSATYLQESRSALLSTLRDAAHQRRGSVDDHSRDPEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W149</accession>
    <name>K1W149_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">20 kDa protein having G-X-X-X-Q-X-W-motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W149"/>
    <dbReference type="STRING" id="1220162.K1W149"/>
    <dbReference type="HOGENOM" id="CLU_1611962_0_0_1"/>
    <dbReference type="InParanoid" id="K1W149"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854151" evidence="2">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="190" mass="20814" checksum="3F7C5B1A2BF9F33C" modified="2012-11-28" version="1">MLSTTVTATLLASLAVAAPAKRQDEHPYSIEWRANLKGYLGDVATPDPNNIRGTHENGNVLGIAVSPNQQGNAMFRRIRTSFALSPSKPGPIRSLKNHSTDDKGPEHCLDGTSNPQNGAVPHFWDCYEGLDVQQWQVRPDGLIELAGTGLCLDYKDGKPTPDQLKGEDQATIQLWACDPNNTNQQWNVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4I4</accession>
    <name>K1W4I4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4I4"/>
    <dbReference type="STRING" id="1220162.K1W4I4"/>
    <dbReference type="eggNOG" id="KOG4115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1448692_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4I4"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19554" checksum="50164F539C5D8DAF" modified="2012-11-28" version="1">MPADVTIPNGSVSSATVPSTPITAAGAPVAPSAPPPEIEATLSRLSAYRNVRGVMILARAGGTGSGIIQSTGSVFEGESGRKYAGSLEAVVAATAGAEDELKLMRIRTKRHELIITPGEPISCTDRANLQTRSTPLLFSKIPASDQPWNPTISDMKALLCRNRSEYGPQPLATTFPTEQVTGWAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4Q8</accession>
    <name>K1W4Q8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4Q8"/>
    <dbReference type="STRING" id="1220162.K1W4Q8"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="K1W4Q8"/>
    <dbReference type="OMA" id="RDDEWAY"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="95"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="653" mass="71658" checksum="F5557609556C785F" modified="2012-11-28" version="1">MTAPALNGNDKAALRELDGVRSEEVAQAGVPAELPGTHAPNEEGQAFSTKSPSLGPSDEMTRNAKIATEKEHQMSLLQGIKLYPKAVAWSMLISTCIVMEVELLQVGTEVGRIAAWRWSGNTLLAPCGPLSVPKLGTARFACRGPPDPALSAGGGCYDVCLLSNFYAFPAFNKTFGVLNRKGEYEVPAPWQAGLSNGANCGEIIGLFINGFVSERFGYRYTVMASLAALTALIAMFWTATSLPQLQVAEVLCGIPWGIFQTLCITYASEVCPVALRGYLTCYVNFCWGLGQVIGIGVIKSQLYRGPDDNLAWKLPYALQWMWPVPLLIGVALAPESPWWLVRRGRYAEAKKNLLRLTSLNRETDFDADETIDMMRHTTELEREITSGASYLDCFKGVDRRRTEIVCMVWAIQNLAGNSFSGYSSYFLTKAGVPGDKAYDFAMGQYAINCVGVFGAWALMAWGIGRRNLFLYGLCGLCVTLFVMGFLGLVPEAHRNQGAMATGSMMIIWAAFYQLTVGTVAYSLVAELSTRRLQIKTVVLGRNLYIVVGIVCSVLTPYMLNTDKWDWGNFAGFFWGGSCFLCIIYCYFRIPEPAGRSFAEIDILFERGVSARKFASTKVDPFEVELHEKAEAQHVERINEKGATTATVMSAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5Z1</accession>
    <name>K1W5Z1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase chain 1</fullName>
            <ecNumber evidence="7">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="9"/>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5Z1"/>
    <dbReference type="STRING" id="1220162.K1W5Z1"/>
    <dbReference type="eggNOG" id="KOG4770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_1"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="OrthoDB" id="531329at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="298" mass="33383" checksum="B1FD00F28F9E332E" modified="2012-11-28" version="1">MGSMQRRVGPNKVGIYGILQPFADALKLVVKETVVPAHATVSLFYLAPIITLIFRLLGWAVIPFGAGLVISDFPLGILYSLAISSIGIYGVLFAGWSANSKYAFLGSLRSTAQMISYELVLSSAILTVILLRGTFNLTRIIERQQGVWYVLPLLPVFVIYLISILRETNRTPFDLPEAESELVAGFFTEHSGMIFVFFFLGEYCSIVLMSSLSAILFLGGYNMPELFVNDTLINLQRIFLRLKTCLFMFFFVWTRATLPRLRYDQLMTFMWCSLLPMAIALVAIVPSILIAFDVPRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6B3</accession>
    <name>K1W6B3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6B3"/>
    <dbReference type="HOGENOM" id="CLU_1005395_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6B3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="277" mass="29463" checksum="10922ADB02284C97" modified="2012-11-28" version="1">MKTQADLQSLLRALGTVSFSWRTFELTPDDPPNAPREASKREINGAVQGNSDGREEGEAARPLASADAPVIVATIAPPHCPRVGQGDSELTSDDQEALAGGGLRQWWNELIPAPIASAGATPAISTASGKDVELIADVVVQAVLKTPSGSNTVTKGKRGASGHAWYLADRQALRSCAANPWGGSAVSCPQLFSQLIPVFELYDSQDDAEVSRELLMSYLFQADTSALAPAKRRSVRLADHFRVQAGPGESERVVERASSAFPDQEGYCRFGGMVNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6T8</accession>
    <name>K1W6T8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6T8"/>
    <dbReference type="STRING" id="1220162.K1W6T8"/>
    <dbReference type="eggNOG" id="ENOG502SDZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353429_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6T8"/>
    <dbReference type="OMA" id="PIMEYES"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="52"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="789" mass="84897" checksum="AB5A022382750CF5" modified="2012-11-28" version="1">MTLPPSSSRAGSIRSTATSTASTSTPVQRSATSSSLRRQPQHANTISHKLRHLFDSSPTATFLAAVTVHELTNVPQVSGDFAIRWKFRGSRPLDADKMLQHPTPRVTGREALQARANARGTGTPTSQPPLPARMAADAASIRSSVHSSTSGSNLANRTIRHAASLPLPRSREHKFSDPPGTPEKRRSVVVEEPQDFGNATPMTPATPDTATDPERTSPASSREHSMYSDGSHGSGTPGASGAGGLKIRTTSIADSGRGRESRASMRSDVSTEASASTSHASPTASTGAASALSGARGAVYSLTTAHYDSKDRKGTIPPAPVRAHAVAWEYAIQHVLRLPLGKAVPTADVSLSRLPASQKTNPRKMLPILGHGPMSDSSLRLEVLQVHNGEREGTVLGHVNVDLAPFADQGPTARRYLLMNSRTNATLRISVDMRCIGGDTQWITPPFAEGHLTDLTDLTGREEEYAELQLMPTRSISSTASDSSRASKASRPSFRSTRSNISLNQQQVNQVTQMTKHRYHSYEYHLRPEHRRHHHHHHHHHHHGHDDEQGQGQGTQRAATVPIDSRATTLDASTSDDAPLSPVLSKNQIVASPLQTPALPPTLSPVTSKSGEYFSLSPTLSPVTPRSPSSPSSPHTSHARYDSTVSALDSLGLSMSRHSPAGFIRATSPIMEYESMQPDLVIESCFNPAPAAELGPFTYTQDSESEAFYPAPASSQSSGDQQASTWEEHHGQAPAYDEDGNPIEPTAVEQPPDSDADGETKAHARWRRIKARIHHHQLECGSEQSSQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6Y6</accession>
    <name>K1W6Y6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsular associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000217">
        <property type="protein sequence ID" value="EKD04633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6Y6"/>
    <dbReference type="STRING" id="1220162.K1W6Y6"/>
    <dbReference type="eggNOG" id="ENOG502QQ3T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305271_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6Y6"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="972" mass="105520" checksum="B5DE31C83AA63036" modified="2012-11-28" version="1">MSLRPRLHTPSAPAPPQPDTPAAHYADPMEEEGSRKNVHKHARNESLPRLTARGHAANGNGNGVGNGGAAGGKGGEEEEEPYDKLRKKNRFVPGQKAWIVIAAVLGVILLAKMVAYRPRTIEVDVSTLEPRDYFNNSQTDPAPFEFCPVFGPGDAVAARRGQFELLRSRLHLGTGARIQRVLNKAMQGLPVTISVLGGSVSACHGAGDDPVGSTCYPARLYHWWNSVFPNPHNELTNGAVKRTDSAYYAYCSAHHLPDTADIVILEFDGSDPNDRDWLAYFEQLVRSVLTRPEQPAVIILGHFSPQVQAQYGFAGPELLHNAVAQFYDLPHISAKGVLYDQYLENPLGALSDLYHDSQHANHEGHDLMADVLISYFMSEICQAWGTHMGNTYAVNPRALHAEGSAGGKAAGAPVPLGGLGLRPNQVPGQKAEDGAVSGEMTSVAAVPRMRIHDRPSALDTFRETEPYCVSAADLVSPLPPSIFFGSGWRQHTPKNKDDRFYWYAEQPGSRLRIPVKIGSGDVGVYYLQSPHGSTKREATVKCHVDDNVGGAKTIHGNAEVEEEIATLTIIDINVAKGSHFVECVLDGEPGGPITPFKILGILERLALGRVLGEELLPLLQHVSVEDIEGGPPNEEQDQPGHLDKCPAPAGLDGGAGARHLPHHAAPEAALDKLGGEFGEEVVRGLEHARDVGQRVEGREGGEGQERLAARAQGIEHKEKRVAQPVDGVQVDAEQGQEVEGVAHHLGQRPGEEHRREERVLVRLALARVQRASLQWVVRAPDRDHIASPHARLYTHTRAHLDNAPDGPETARDLAQNGADGGAHNANRGVHDLHDGQGLDILGRLAEAVKVVRAREVVAELGEPRQRRRAMRALPEHRDARVARLLERSARGEDEPQRQVEQVAPRDGRDGVESEQIRLDQRVGFAFRRRRVEAACFRGVGGCEGYPRQAVEGEAFARVSVGVSVRAIGVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7G4</accession>
    <name>K1W7G4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7G4"/>
    <dbReference type="STRING" id="1220162.K1W7G4"/>
    <dbReference type="eggNOG" id="KOG4191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152441_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7G4"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="241" mass="26498" checksum="74832BA3F5E5A60C" modified="2012-11-28" version="1">MLNFKADTPESYVIPPRGRHYTEIWDEEDGNPPGTTPRVPVPAMRQPTTNQPVVHCVPTDLRDPNLAEENLGLGPMTERVVAAVVAGNDLADAAKQEAAGKPEPFEENPQAPRVDVVDLEDKVKKELRSTMLLGEHEETAINDERKARLARVAKDRLAYGEYQNVLDEIEKSIEAAWAKRTKKHGSGGKQVLQGGVISGAGRPPVPESFKQKLSVRDRWIKQVGKTMLDRPAGEVIGTPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1W863</accession>
    <name>K1W863_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W863"/>
    <dbReference type="eggNOG" id="KOG1310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247776_0_0_1"/>
    <dbReference type="InParanoid" id="K1W863"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="719"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1520" mass="167855" checksum="4823F7CF1E1584F9" modified="2012-11-28" version="1">MPRLPRKIHQTVNSGPRNSTLRPFGPDAWSRLDRVQELGPEGEGHTGCVNALCWSDDGSILLSGSDDTRHDTPSTSPHPLRLKDSILTGHRGNIFHTKFLPNANTTTIVSAAGDGDIRVYEVERLTTNQGVGMRSRNELWGVDGPGSSPSAKTVPSFVPGTRRSGPVLPVSVATDALHLRSVPSWGPHTRQAGQVSCVRRLGLPEKEWSGVSSRSRAYSERHVTSVKMSTDHSGEVVGAMAMHSTSLFSMYDDPVTTSMRSNESGVVAPNGKRMGASISKRRHSGGSDEDDNPPRSRTKSAESPRQSNDHHTRTTRTKPIDEDDDMREFLSELYEDSAEERRMRAAQFLYSDSESDNESNAAEPSTAATVGATTDQASVPAAEEDDEAKSGGEDEPPAPLSDPEIDAEVRAEAQAAQRLRRMFANLSDDEDNSDDDEESMELDTVIDSEFDDEDDFDDDDNFYCPGALSSDGQFKDVPLIHPRRMYKGAQNYETVKDCKFAASAGAELTSGNFVGNASDKVCSGSDDGNFFVWDKLTGRLEGVWQGGRDVVNVIEQHPTLPILAVAGIDNTPKIFAPTAQPQKPSFIRTHMADRIIARNSMPPPYHQSSSIDSTALQFLSHLLRARGNANSEADRIRLMSFLRSTGVHLPDDDELDSWPAPVRRRLRPSPIVHRRLEEAEEVRSRAIASARCRSATGRRDFGTTEVEVDHLLFFRTRLIRPPSPRPPERSHHAHPDRTAWRTGSGHAGLSADGSPPVVHRYGVGSPAKPKRSPTKSKKPKAASRPLTAKDPTTQPPSETVIAALPPSSLSNKKAKEDDLIRYLDARELEQSLRIWNDFLVATDVFRDLQPETYAKISKFIVETASRRNGLNIGRWAAHDPERLETLLHMAVEASVHDNWRGFNALQLELIGAGRPHDVVSAYGQFKDSLFAHQGKDPKGLVSWYREERLASRLTGDGLIPLMLGYVAAQTMLGQFDHTVLISLMDSAFDGRLVQRDRLDLSALKYQIRSPANQGASEIVWRQFLANIDKVTLAIQCYHSKALVTRIRALARHGDVAKVNWLYESLMKASVGPDRFIIPVDSANRTANYNFLMTDALIDAYANFKDVDRVVHIVEVDMAARYPRIPTGGYGVALRSLSSLSSTRSKKTLQQQAEKKVAEYWAAIEARGEDMTLESLDNRLESLSNLGKPAEAEKLFRRAVIALVSRGEDTVDWRSRLAGHVFNAYCRAGRIGDAERLLQEVPTPTGPPSSYHRPFTLGVLHAQAEDNVKRKLLTQVLARIGDAHVVGADWGRILELLLRSGWDVVGTTDAIATKQELAPTVPARWWYSFLSGLTGSSARGVRPAALEAAIHVLRSHFPRGESTSPTLTVLAWSVVQLALARSDALSAAERHAAMEEVFALLPSHIEANQIRARVMLASLARKDGTGVPEALHQWELIEDWVPPVVYTDTLKQLLRLGQRGVAEDLAARIPNTNRFRHVAAFAREKRLVDHAVRGLERSHTVEVDMDEIEELDEEDGQDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8W5</accession>
    <name>K1W8W5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8W5"/>
    <dbReference type="eggNOG" id="ENOG502S77C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060561_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8W5"/>
    <dbReference type="OMA" id="DIEHGAN"/>
    <dbReference type="OrthoDB" id="2592504at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="273" mass="29919" checksum="EAA6A35D177FF2BE" modified="2012-11-28" version="1">MPATKTYMISDDPDVEYKWSCNQIRGKLRKYIENGGAKTTEMQRELGVNSNSWGRFMRYTGSMQGCDGGVYEAATRFFLDMERRGEKMPKAKPAPVAGKENAPPAGSAAAGIVAEAGKPASEGKAKAPKPTTATADVTGVKLNGEDTDSVPVYDSCDVVRRKIEAHLKLPGVTRAAFLRDLGAQFSEKVNIQSKQLNDFLAKRGPVAGNTSRVYYAGYVFFEKRRVALDQPKNAHRLGMEKSHPGGADTSRMRTHILCRADEILVEDEFGNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1W970</accession>
    <name>K1W970_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isopenicillin N acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W970"/>
    <dbReference type="STRING" id="1220162.K1W970"/>
    <dbReference type="eggNOG" id="ENOG502RY9N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037787_1_0_1"/>
    <dbReference type="InParanoid" id="K1W970"/>
    <dbReference type="OMA" id="QNWDWER"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="2">
        <location>
            <begin position="246"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="398" mass="42589" checksum="A228CC6F976D6FB0" modified="2012-11-28" version="1">MLRIECSGTPYEHGTQAKSRVHGTLAFYQAFFRETAKLPWDAVETKAAEWLPLLRESYPEILEELEGLAAGSELSKETILALNVRTEVAFGLYTDGCTAFAIHGPRNGILSQNWDWKGAQKGNIVQMTIRREGRPDLSIVTEAGIIGKIGLSAGVGTTLNAIAALGVDSTRIPVHIALRKVLDWAGEEAVKHAGTADGHANGSVHGYANGTTNGHANGDAKGKTNGHANGGSKLLAPPGTAELLASRLEKLGVASAGHIIISDGSQAIGLETSYIDTARVRHIDVGEWDAIVHSNHYIEEHPGVRLGTNQMPDSPARLARISKLVTQSLGGLKDDENVLDTVWTWLKDTEGFPGSICRDGAAGSETIFSIIMDLRNNVAKVKEGKPINDGEEFTLRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W982</accession>
    <name>K1W982_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W982"/>
    <dbReference type="STRING" id="1220162.K1W982"/>
    <dbReference type="eggNOG" id="ENOG502S4J9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091402_1_0_1"/>
    <dbReference type="InParanoid" id="K1W982"/>
    <dbReference type="OMA" id="RWNDQYK"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26130" checksum="067750434C474D4B" modified="2012-11-28" version="1">MAPQPDPRPLPDGWVSQFDSNYNQYFYGSRGPQVAVDAVSTVRVYATEPADKIPTDVSPADDPPQSESNQYAAPSGPPPSNNEKSSYNNNSEKYSTPPPQNNTPVQQGNQGQSSHRGGLFSKLSSKLNNHHSGQQGYGQQGYGHQGYGGAPPPPVYAQQGYGGGYGQQPMMYQQQPMMMGRPQRMGGGMGPGGAAMLGAGGGLLGGMMLGNMIADGQHDAYMDGYMDGQDNDFGNDGGFDGGDFGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9I0</accession>
    <name>K1W9I0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9I0"/>
    <dbReference type="STRING" id="1220162.K1W9I0"/>
    <dbReference type="eggNOG" id="ENOG502S6RE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305696_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9I0"/>
    <dbReference type="OrthoDB" id="2595585at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="963" mass="104375" checksum="C2FC91B9ECE77F5E" modified="2012-11-28" version="1">MKRRRSSVSELRGLSRLFELDELFLRVLGYLDAEDLANAQRVSKHWARLAVDPQLWKRLYLPFPPPSPSSSPAPSDDEEPDVIRHEGVDWKRMVRLGTNWANGNVLEASLPLPLPPSPISRPSEPGPAEHHLALFPSFICTASPTSPLVHVYGVGSEPKPLGIVPPPPGWSSPNRPDNVTAICADEAVQPPDGAADGRPVLPARLAIFYASGGFAIVKLRFDGRLVWTRESVWDRRTRPRRTGVQDDGDPVVLAAFHHPVLVTCTLSFHVSVYMLSQSVSLVRTLHSDVAFHPAALSLAPHGSSYRATLTYCTPVYPSSWTVSVQELAVELGHGGEVRRGECYRVRSGRSRRAVTEWPRRLDPVDAVSRAVGVGTDGRWVVLAGEDSVIHVFALPSAKGGIAHAQTLLAPSGGVSALALQSGRCVSGGADGKVLVWELDDAEPEEEDGARVGRTLGYVEVRPGGRRKVEPAPQAAEEEDEDEDEWELPNPRSLAYAARALFLATPPASLPPAQHTEGGINSVTQLAFDEEKIVGLLTSVDDGPSAVSERALPPGRTPLVPIPERDLLHTCSRSGEPAASSCVGLRISTGSAEHTNTSYHDDDPAGVHDRLCVLPEANREEGRIQAARAEDVVHYEVVLLLLRYRTLLPAPGGALGTLSDKGHAVLHADAPDACLIQAELAVLEPSPADETVVCAENAHRVFGQLDVLDHNAARDALLAAVHCNAILREGGEGTVHERLGRNGEGEDCNDERCHVERFRFLQRESHGGKSEKKHAGGGDQELRYQLGTRRRAYGSLGVLCEECRDAKTELGGKKKRQSNKRGDKGEGAEDKPGEEHQPRDGSEGCPRSDTPAELRRGQEPDAPDQERGEGRADRGPDGGIANPRRASRESVPDHGEEGKDPEYRLCVIDESAVIQRRQTQLGQLDAHDENARREHACLSAGWSRPFSLLRAASLAALMLEDVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9K0</accession>
    <name>K1W9K0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9K0"/>
    <dbReference type="HOGENOM" id="CLU_761160_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9K0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="342" mass="39056" checksum="BABA373E044D0C8D" modified="2012-11-28" version="1">MPELRPVHWSIPGYFDGRKTPAMMLLESPDFNKYGGGRGLKVIRLSPSYLASKNGPGWKMPDIPAAARAHLPDGRTTLEMTRGEFAFHVSEQFYEPMMDATEAFADRFNAAAPDLMTEVLLRWNNTYWPIDWSFSYHLRLGRRRVLATKGESGDPLCVSVFLDPAKPAMIHVCATLPVLDKEVEDDLSALLCEILNAAAIAWRTRTRATLILRHTEYIYVSFEESSIEQPIPTIRISTVQHDNPAHPNTSPHPWGFTFLNLVMANVSWWFKEGGDKRWQPCQQDRYYERHCKPEHLVESPESQSDALPIIEEESVAENRDTTKSKDDRGSKPMAKKRRSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9M2</accession>
    <name>K1W9M2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9M2"/>
    <dbReference type="eggNOG" id="ENOG502REBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240363_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9M2"/>
    <dbReference type="OMA" id="WHEHEYH"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1559"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="964"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1142"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1391"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1674"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1394"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1441"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1684"/>
            <end position="1693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1718" mass="185668" checksum="C7A9F68EBD33FB24" modified="2012-11-28" version="1">MASGGEDSPQVMAPPPPPSRLPVPQSPAHRATRSGILSSSAKGWSPLQITKRNPDSVPSTPAKETGSARRSSNSFRHMATNSLVAKSPFKDIRTVQGAMSAGLDCSTSSKKEVIHERRNPNRALGQAPTAAAGSANTPRSAVGLGKSRSPPGSAVNGTRKVSNERKVSIPSTAERKANMERKVSREENDENDNKGSISKKKKLPRQSMAYKALVKNEYVTHSPFLTERANNSADDSEFDETEKSIQPSIGSPSPRRTSSGSRKRLASPSANLAQNRTSMSSAASPSKASPTPAQQMSPSKQQISPSKQMSPGKENFPARTPTKSSLVSKRMKGPRSAGSASPPARRKSVSFQPIPDVREFECPSTDVSYNTSVEPTSVPDTDDWYDEETSWVGSIIKDEVDLEFRPVAQVHAPQSQQQVQDQDRSFDSMEEQPMGDVSATADFMDSLYEEGLFGGDSMEQDTPVVEQRATFDGPAESNDDSEGTNDGPQLTTPHMPNSSLPDQQIGFPSSPHHKHTIHPHPPPIEQPHLPHNEDHRMLLNADVSQPHIPSPRKESTPDAPGPHAHQVGAMYDPFISIQTATEFVGDAKERSEDGVPLGRTSHADRVHAARVLATQSLGLGFPGRSRSPTKSGSNSGASSPGLSDGQATPVPQGTPKRGGQPEEDVFGAVVTSPAAARKVSPAARKSLDRKVSDVPELQGPSSRMAQFRAMKGSPSKRSLPKPPKSPAPAPQPIGLPSPVHDRAYSSASESEVEPVSESEGEYRQDVIEDTQSKRLSDLPPPKLTLGEDLESALSPSPPPRLALSPELEEKSLQDITVDDEPYRPETPTHLPSSPYADSPLTPSQRFARRAVRDEEEDDIFTPPRPHSENRERESSPRIPSFEFEPSNLSIDVDVDSDSSIDGALHALGGMQITDGRDLMEGMQSMDGMHSPSVRSSVCSVSSQGEYATPLGSVDDHEDSMDTTIPAIRPPPTPRSGSPAMTRTSSPATPTRAGSPKVSTPLRATPSRAHVTSPLSAAPIMATAPLAAEGEFGPQVPPKDDAEVSTTTRIRQRISRDAIREQVNKRVAAGELSLNGRPTSVFQPQTTAEASPVKLAARPNSANGTPVKLRSKKSLSNITAAASSKMDSPKSALDRIAGVFKGDESTETASAAPSSPPLSPPRSQSVAATTRPAEPTLPRSAAGSIVDDPKALAAARKSRRRSNSTGDIGSVNRRAPRVTLGLDDDAVSILDSFRDETIDESVSEKHYRIREERRQVRATYTGSGSLSSRSGDNDSIKAWRPIRRPSDMHEHSIELRAAREREAREGKASGTVFVKVLGIESLSMPMPKEPTFFRIAVDNNLDYIRTDRFFELKEGAKINQEFVMAESENFEFSIAMEIRADPHILRLMHEKANPPTAPAPTPAPTPAARPVTPTSTTSHKSRGLRALFGGTPKKNKHQRTQSVPVTSSAPVKKPSPPAKRPDTIATFFAPGGDTTLAKTHIAFKPIAEQCEAKVLEIRYPMFAMVKPAPLPDGTAPRKQLAKITIQVLRLPPLPGLGPDNLPGSIDETLRGLRHHKWHSQVYHEGILTQVGGDCRVPRRRFFKLIGGSLVAINEVTKKEVARIDLREASALVDCNKPGVEDDYDPFSARPRSFQLRFTDNEAIVFSADKDDDKAVWMDTLQGLLGKVPSNPIWAEMLSQSSKEKRDRRRSKRRSSAMPPPASTSSRTAGRKSQVPTVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC60</accession>
    <name>K1WC60_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC60"/>
    <dbReference type="STRING" id="1220162.K1WC60"/>
    <dbReference type="eggNOG" id="ENOG502S6W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110814_1_0_1"/>
    <dbReference type="InParanoid" id="K1WC60"/>
    <dbReference type="OMA" id="HINNPLM"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="186" mass="20779" checksum="3F0FC82D0D216BA7" modified="2012-11-28" version="1">MASLFRSRALHTSARAASEDTRKATSDFLARLTAGRNSGAASAASTNSAARSMIDSVGLRDVTDERRRPFLPGKPHNFTSKDLYPEAEIRVKRPLVGPRRKVAKQIDPFFLRGENPMDHINNPLMSYAFLNPLGMIKGRNLTGLTWKSQRRVGKMIRRARHMGIIPKWAAQPRPGGLGDRDFARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDM3</accession>
    <name>K1WDM3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol glycan, class F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDM3"/>
    <dbReference type="STRING" id="1220162.K1WDM3"/>
    <dbReference type="eggNOG" id="KOG3144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064564_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDM3"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30078" checksum="128A2175030344CF" modified="2012-11-28" version="1">MSTSSATPSGAAPAPAVVLKQTLPLKDYFSTLAYLSFLLSTTVALLPRSTKYFYPGAVTAQTTSADRPEHPFLTPITANPTASAAWIAAGTGVTVAWLGNRFGRWVGARGDTLLAVLIATPLYSGLIHLLGAPGYTWFRTLLTSLTLAFLTTYVPIYILGFPSLYDEGIADRYRLTRLFSQWTPETRLETLIVYPAVGAVIGAWVGAIPMALDWDRPWQAWPLSVLVGACAGFVAGGYCGWASCAFKGLKSDIAAEQRREAAQANKPKSSGNARRRKPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFS7</accession>
    <name>K1WFS7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFS7"/>
    <dbReference type="STRING" id="1220162.K1WFS7"/>
    <dbReference type="eggNOG" id="KOG4778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090382_2_0_1"/>
    <dbReference type="InParanoid" id="K1WFS7"/>
    <dbReference type="OMA" id="ERAWFLH"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="203" mass="22962" checksum="0643F8C51E5BED11" modified="2012-11-28" version="1">MSALASSSRARVAAPTLRAVRGMAGLNPHTAQSTDARIDIIRNYLYPPDSVEPRNTSPIGARRYEFEERLRAVIPSNEAHETIERAWQLFKREKREKRQRAIAAKYRAMEDACNELDALSGGVQGKGEISRKIYTRAMQRMNHGPAAYQAALQGIEQGKKKTAESRFLEARVDGLVPREAWVPVDSRGKGWNYEWTRPLNVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGG0</accession>
    <name>K1WGG0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucokinase regulator family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000339">
        <property type="protein sequence ID" value="EKD00579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGG0"/>
    <dbReference type="STRING" id="1220162.K1WGG0"/>
    <dbReference type="HOGENOM" id="CLU_761158_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGG0"/>
    <dbReference type="OMA" id="SFASVEC"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="364" mass="38752" checksum="AF21D9093804BC28" modified="2012-11-28" version="1">MPAYLCIDGGGTKTSAWIAIRDEAGTRMARGVAGSGNLTFGVDVVLASTSAAVSAAAAELNSERGGEWPPFEAVWAGYAGCGRVSDRELLYPDLAPLFPHASLRLTGDGDLLCAPMEGLGASLICGTGALAQLWCVPPHGEPVRLLRSGGWGPVLDDRGSAWSLGKAAVCSVLFYAANEMPLLSWQEQLLRRLGTDAEELIRTTSALDTGLSHADADSKRKTTIAGFSDLVVAAAEQGDQEAARILRRIAGEVCEILEPVRAKLDTVLEQEAQEMDDEGRQRDGGERKEATLVVAGSLGLNATFWSFVEEQFRARGWVWSRIAVADPARVGLEHLLRNASTSGRSVKERVSGPPPRLTSSVQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHP9</accession>
    <name>K1WHP9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">A1Q2_04676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHP9"/>
    <dbReference type="FunCoup" id="K1WHP9">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WHP9"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="InParanoid" id="K1WHP9"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="80"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="31569" checksum="21B44A1F52CA7974" modified="2012-11-28" version="1">MVAEVEAAYLSERVTRCGVSGDKSNELEYLKKLVSQDKIATIEAKAGDAASSAKDKVSDAISSVVGDKEAPKLILIGPPGAGKGTQAPAISEKYSVCHLATGDMLRSQVSQKTPLGVEAKKIMDAGGLVSDEIMVNMIKSELENNKDCARGFILDGFPRTVPQAEKLDAMLEDKGKKLDNAIELKIPDALLISRITGRLVHPGSGRSYHREFNPPKKPMTDDITGEPLIQRSDDNAEALQKRLVTYHKQTVPVVDYYRKTGIWAPVDAAQSPKLVWASISAILEDSQKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHS0</accession>
    <name>K1WHS0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal iron transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHS0"/>
    <dbReference type="FunCoup" id="K1WHS0">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WHS0"/>
    <dbReference type="eggNOG" id="KOG1291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_4_2_1"/>
    <dbReference type="InParanoid" id="K1WHS0"/>
    <dbReference type="OMA" id="YEYYPRT"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="64166" checksum="C677DF255A89DB76" modified="2012-11-28" version="1">MVTLSKVKEVLKRHANFIGPGLVSSIAYIDPGNWATDLEAGANYGYTVVLQTLSVRLGAVTSNSLPKETRKLFLHWEAEYPKYRKLFRAGLWTLWALAEIAIIATDLAELLGSAIALNLLFPKLPLYAGVLITAADVMVILVFFRSNKGRQGMMFFEIILVAMVLAVFVSFMILLNLVKPDWREVFLGLVPSSTLVKPGALYIGIATVMPHALFLGSHLASVDRLNMRPELPMRTRKPMNQRLPSILSSLKMRRRRPGNTSADNVELDNMERTLAAEPVCGSIAEPSTPVTPVTEVPKKDDDRDDDDAEYQLALKQYEADVRTFDRIRWVTLHVNHATVDTIYSLLGFALTINSAILTLAGAIFYYGTSGVSADDADLVGAHNLIRDYVGNGGAIIFALALLCAGQSASITATLAGQVVSEGFLQWNINPMLRRVITRLIGVIPAAVVASAVGMKGLNTMLVASQVALCIVLPTVTVPLVYLCSRKSVMRVEGPVQELPSSRPPSPSGSAVSAPARQRQLSSLGRSTAPESECRPSTLAGSVQSAPAAPAPLGLRRVKHFVSPWWMTAIGWLLCAIVILANGYVIVELALGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJH4</accession>
    <name>K1WJH4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WJH4"/>
    <dbReference type="eggNOG" id="ENOG502S1Y6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_226639_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJH4"/>
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</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNX4</accession>
    <name>K1WNX4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol 3-phosphate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WNX4"/>
    <dbReference type="eggNOG" id="KOG1089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001839_0_1_1"/>
    <dbReference type="InParanoid" id="K1WNX4"/>
    <dbReference type="OMA" id="RTMEGFM"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="188"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="868"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
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        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
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        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
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        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
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        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="424"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="886" mass="96523" checksum="7664764530DF35D4" modified="2012-11-28" version="1">MDGLRVAKIDGVVLGRTTREPPHTKLKVTGTLHLTPHHLFFSPSPPDAQEAAATESGDGDTDASHPAAQEEVWIPYPTIVLFQRLPTTKDGYPLQVGTKTFDNYTLWFAKDREGGAEDVWQSVRDCAVVQSVEQLYAYFYTLPKSPAAAKAPLLATPARQHSSDNPLSPLSASPEKPTTIEAAAAVDGWGCYNPRQEFARQGLGTRTKAWRFTDINKDYTFCPTYPSKLVVPSRISDSVLSYAAKYRSKARIPALTYLHWANHPMVGIKNARSAQDERLVECIFMSHHSSDSALALSPTPPLASPGVGATSPPVFGATATNLIIDARPTTNAMANVAKGAGTENMDWYRFGKKAYLGIDNIHVMRSSLRTIVEAIAEADASGLPLDRERLRKSGWLKHISAILDGSVMIVRNIHVNSSHVLIHCSDGWDRTSQLSAVAQLCLDPYYRTIAGFQVLVEKDWLSFGHMFCQRSGHLSSTKLFTATPDNLDGDEVSDDDFGNAVKGAQAFFASVQKQFTSNSHLKEVSPVFHQFLDCVRQIQRQFPDEFEFTEDYLLDLHYHLYACQFGTFLFDNEKQRRVPAGKAGADRTVSAWEWTSLPAQRSRYVNASFAPSEGDDGVLFPDTKDVTFWHRLFKRGDDEMNAPIVERERDFLSPPGTSLESEDPLSVPRRQGSHSTLNSLSSAPSTPLATASSSGVPRSKSSGGGWNWTSVRSGALSAFSQFKATATDAIQNMAAHEDEDPWGTSNASHKYAAGTGIGEGRIRAPLETNPWDSTRVNDVSSFHSSSTASVSGLGAAPDASAGTATGDHAVAKKASSSSKDSWANPWDDTPSSRSLADLTLDDATPKASRVTASQKEERKQEPSDEDKALYEAALSGSKAWDPLGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP10</accession>
    <name>K1WP10_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_03014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP10"/>
    <dbReference type="STRING" id="1220162.K1WP10"/>
    <dbReference type="eggNOG" id="ENOG502S2NB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842472_0_0_1"/>
    <dbReference type="InParanoid" id="K1WP10"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="36259" checksum="60D2B0F4D43CE5A7" modified="2012-11-28" version="1">MATLGTSSASTPAAPRGQVANGPLPTLGTAPSTGAYLNGSHPRPATPPRTPPGGSSRRPGSGIFHPTADTSTYRDLLLFEERLKMNAEMLRRRRRRYSASVMVVFITLALFFASGMYDEKIRYAHRSLRPLNMYFNVRRARGGLWDMLPLPAALRPSPVPLKAVNNTSTMNEKRPPGGHRPSTRRVSNSSHTVMAQIPPSANPRGELIFSSRVDPHFEEGYKRYRASSQLTGERQDLVGPERRRLIQIVDSRVTTPNAHRRDHVVPRIALEVFELVARLDARVAQPGARAGAGSGRLGSRPAAENTIRGPASERCARRRHLGHAHVALLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRX1</accession>
    <name>K1WRX1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRX1"/>
    <dbReference type="STRING" id="1220162.K1WRX1"/>
    <dbReference type="eggNOG" id="ENOG502RB7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304801_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRX1"/>
    <dbReference type="OrthoDB" id="2563869at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="234" mass="25029" checksum="4AB4409982522424" modified="2012-11-28" version="1">MASNALPPQRPSPLFSYYAYTISSRDRVHASLLNSYASSSSSASSRTPSSSTSSLPTPGGGGRWKPRTSVPIPPHSASAARRSSLARAQRRALTGKRPAGFAVAHDLADLSDEEAALDEEKASINQFGHRFLMPFGRRMTLGEMETAPSPTPSDPSHRQEEAHAISPSPVPEEEEGAEVDLDADLEDMDASDDGDEGVSGQIEESGEYDSDDVQLMEDMDRSIDSAGGSDMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU32</accession>
    <name>K1WU32_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU32"/>
    <dbReference type="HOGENOM" id="CLU_2005508_0_0_1"/>
    <dbReference type="InParanoid" id="K1WU32"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="124" mass="13061" checksum="64179F2E7B03769E" modified="2012-11-28" version="1">MPLGTARLIRHTRTASLHRHVNAVTPATPLGARALCMPPGKLCRTHPVAAAAASLPENDEDSHLEELLKATLPPPSEGDDLTPEAALAELRKISRAAKQPDMTAPAAVDAYRSSLGGKAARLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWC6</accession>
    <name>K1WWC6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWC6"/>
    <dbReference type="HOGENOM" id="CLU_631915_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWC6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48021" checksum="B7243DAB6F99551E" modified="2012-11-28" version="1">MVSSTPAFDAAFYPHLLDLIVDSASPELLLSLRQTCTRLRDRVQAVLKQHLIFDRRGGRTLYGGLWEDAWSSGVSTEVLDLGEGNDWAASSGALTRFASGAEVDILRTFSDVSAGIRSRRVYYFASPAWGAYVTPHLVPRCASLEMLVVNVPYETHLPSIDHMRTQAGYEYLNRGLECLGTAERVVILFSPRTTFTPPRPKRTSGSAPYQPVYSPSPKAVTRPDTQAPPRPEVDGDLRTAHFKEVDDLAQTILRSGLSTVFELVGTEQWTFPELERAADESKPRNLQHKVWIDMVESERAKHPHVPVFEIMLRAVLRFYAVSDHSRHLASVAMAGPLPTTTVEDRYQKYLARIVFTTRAAFKAREGERQFRLMTERYPGTEGGVGLQGRNMVKGTAQVTGTSASVADADATASESPPLAHSSPPRHTPKETGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWH5</accession>
    <name>K1WWH5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWH5"/>
    <dbReference type="HOGENOM" id="CLU_1846503_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWH5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="139" mass="14948" checksum="47CB027DEFB667BB" modified="2012-11-28" version="1">MGCRHHVTRLAIDQTPSAGSPISIPSVLLKDLVDLQPVTASCHAAEGHMPRPVIVLGSEVVLSIPPGQVTGESARGRGDHGRIPRRLFVTVLEDIALSRESLQVTTMNASTTDSPDRTTAVATEVLRYKACMARKEDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWU1</accession>
    <name>K1WWU1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000141">
        <property type="protein sequence ID" value="EKD05164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWU1"/>
    <dbReference type="HOGENOM" id="CLU_727994_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWU1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="380" mass="42212" checksum="225CEA18139A805C" modified="2012-11-28" version="1">MTSSSCVWLDALNHPYLIDLIVQCSAPDVLLSFRATSRWWRRRVDALLVRHLVLDGQVVSTSHGHACAARLHFGIPLMPLMIDEASYGRYAPPTSRWRQRARRSADSSQSAGVEIPDPVPFPIMDVSRTLDLTRTSVLDVRGAVRKGVLEAISKMVGRLDTIRVYDYPTSNSYPVSNTCSVTWWFGVHEDHPISARRCVLFGSLVPYHGLRTNPLHFCPADAEELIVRLEYNPHRPLARLNALFPRTPDTLRRAVFLFVPTNREPVLSSHDQFGTSLSPGGVAASLTQTVIRLGVPVLFVGAEALAGLPGIADVPVEFVTSERFRMVVGEETWALFTNEAGPAPLMRIGKGEGHGFQHINMNQDSYAQTDRTAWRNLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXV0</accession>
    <name>K1WXV0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXV0"/>
    <dbReference type="HOGENOM" id="CLU_1050484_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXV0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="265" mass="28124" checksum="745567A784927A1F" modified="2012-11-28" version="1">MPPAPTNPPYPPPTFNPYERVTRSKGKVTSESQPLGIADIQSPTASMAMSPASSMRPGPGLASPSTPLRLPRLPLPPPPPRQRVLVSLFHCFGQANASGTSPEPDAEVPTPASSEVHDEESDSESEAETRKGSNKGKGKSTGGSGKSILGLVLRTAGDAPKPASSSSEDSNKGESSYGSASNPPTPVSHVRGQRDGSIGPMRGTWHWVEYRYDDRDDDERRAHPRPGYPGYEAYRARQRAASRNATPGPSGSGWRSASPYDRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WYF7</accession>
    <name>K1WYF7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000044">
        <property type="protein sequence ID" value="EKD05644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WYF7"/>
    <dbReference type="HOGENOM" id="CLU_1563990_0_0_1"/>
    <dbReference type="InParanoid" id="K1WYF7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="171" mass="19450" checksum="A78ADCABE8706793" modified="2012-11-28" version="1">MLPMVADELPDLDCHNVLHSITQFPQEFTPQTLWHHQGAWASLTSNSLVHLDQVVKVFRVNLPPVPIDPYEYRNARYLQLEEHSIISIRYPFCLNSAPGGFLHDYRLDILDPQPRTVLPRDPVPDSLVDAVRRHVTGMCQLLARQPKSPGNMNAAALAQYIRAATPQYSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V130</accession>
    <name>K1V130_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V130"/>
    <dbReference type="STRING" id="1220162.K1V130"/>
    <dbReference type="eggNOG" id="ENOG502RB9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058099_0_0_1"/>
    <dbReference type="InParanoid" id="K1V130"/>
    <dbReference type="OMA" id="EVMYNDF"/>
    <dbReference type="OrthoDB" id="10260248at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851777" description="PBP domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PBP" evidence="2">
        <location>
            <begin position="37"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="305" mass="32864" checksum="AD72ECCC267175AB" modified="2012-11-28" version="1">MTSYSLTLVLTFLLPLFHLVFAQSPEAIYDGGIANTTSGNSTVGLRIGNGGAGQSGLVKVLADKFISESVANGSSPFTVAWYVSDTTYSIEYLASGILDVGITYSFAAEKIAIQRGIATDPPYYAFRDHFLLVGPQSNPANLNETSDISTMFADLHEAAEDKSKNGTVRFLSRFDKSATNIKESALWTGIGQVPWANTYSKWYHQYVAFPLQALEAAIKLGEYTITDRGTLLSLDAGIANKTRIFKAGSDEADDPLLNPARVLVGAKAPNPDRARQFAQWVTGPSAQKAITGFKKNGQQLYTGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9N5</accession>
    <name>K1V9N5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000411">
        <property type="protein sequence ID" value="EKC97450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9N5"/>
    <dbReference type="STRING" id="1220162.K1V9N5"/>
    <dbReference type="eggNOG" id="ENOG502SAZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680052_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9N5"/>
    <dbReference type="OMA" id="RIHILRC"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13013">
        <property type="entry name" value="F-box-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="405" mass="44650" checksum="7C66636F38B4B2E5" modified="2012-11-28" version="1">MGCIALFEGLMAVRARFSAQSDEFWGMREINLAANAIGDEGLVAAMFYCAKDMCMKELLLQRNQVTLEHVVVRVVEKLNASRLAKLSLASNPLNTAAVCTMFEMLDAPYLHALHLSACQITSDLVPALCAFLRSPRSQRLQLLELNGNMLGRAGVTAILDAIEEANFSLSRIGLFANTVRRWATDDNGQPAGGTGAAENGGVGAGGPEGAGRPDNSAPDAQRTAGDPDPETEDPNDHASMAWQIGERLPALQRRNGTLWRRVREAAVKSLAATRMILHAREPSDAETAQRVLASADPDAPSQAVFRLMDLPPELRLLIARHCSRDAYAMSDAQWNRVRSHAEKRETLLRMRNRVRGATEDATSYASKRSREVKVCRQWMEEVGCDRWELENGEFWDKWTKPAPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCK1</accession>
    <name>K1VCK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCK1"/>
    <dbReference type="STRING" id="1220162.K1VCK1"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012510_1_0_1"/>
    <dbReference type="InParanoid" id="K1VCK1"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="440" mass="48938" checksum="D3D4E039F81A5B4F" modified="2012-11-28" version="1">MVSKRDTRTKAVRTSARPLVEPSENGLEVVAGLGNLTSGDALSVELLLRHGASVTECDNSGLTPLHWAVVKGSVGCIKKIVEAGGDFDVRDNQNKAPRDMAVELKGESNLNMALDEANFYRDGHRIQPRFSDRVTMALAFGLPIVTLLIAFKNFEWLEWYYAWPLLFVTMWLMQLVVLKHIPLANRTQYSPFFPSIIIASLFWVGEVWVTRLFAGTPGYLVSNLCFVLAFAACSFCLYKAIRADPGFVPVSSEAEIKAEIEDLTDEGRLNGTNYCIFCMLYQIMRQMTTFEVSNLGRYGYMGGRGGTSLREQDGAMAKVYRANPQAATGERECEHKHGHGRCGVPGRICSALWMKITGPLFRLLGFDRFTKGKAVSGMARARRDQNPFDLGLVKNCTDFWIGANGVDYVSLYDVPPEGWAAYRKKMAQGAGYERVAQEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCN9</accession>
    <name>K1VCN9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCN9"/>
    <dbReference type="STRING" id="1220162.K1VCN9"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628801_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCN9"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="436" mass="49883" checksum="8C4C5DD4D839F4CA" modified="2012-11-28" version="1">MDDVLEHDLDSHTGPTKFHLPPLPSPSRRRHSPTPTTKLAYQAHLEDQAKLDKALAKRRRIYDRDLWYMHIPSNKWTKYTNISPYDFRSSSEVGNGESSSDPASSESETARRARSFLTRELQLFPQVDPQATTTQLINLFKVVDLRSVIAGNLLHDLIGIEGNRVLHELYSFLRSPFELEDWDDINQYGADECPRGRTVSRSPPPEAESRGRSRSRSRTWSRSRSRSRSWSRSPSRDRWSRDQSRSVSADRDRRRRGDQFVPPVLSGERRWDKSDSWVDPEFARPRRRRRGGKREREREARREAAKERDRIGVEQPHINPALAGATGDLSIKGSAERRQSLLERLAKLKSQEVAGALQQTVVVVDTSKTESNTSSPQNEEDKAAQLREKLIAERKRKVLREQLLARKKAKTEARTENNGVTIAAAPPQPTSITEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCQ3</accession>
    <name>K1VCQ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCQ3"/>
    <dbReference type="HOGENOM" id="CLU_694808_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCQ3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="397" mass="43845" checksum="4F543AB3744CD82A" modified="2012-11-28" version="1">MATLPPNPAWATCDIVDEAHNATRRQMKTIRSWKGVDDSAEFEFDGGNWKIGDWLEAFEKRQLTPAGAGYKRGGQASLHPDARYRVVAREDMKQIVLRSILQHMVHAVNNGVTSNLKNCRAWLLGACWEETVFVLPEGGLRCGVNELAYMAVIPVTIKGDVARTETVEVAHEAVDETAEELDPEAQVAAARAFAATVPGGNAMVVYTPQTVERPRETYFGHELQIRSTCAWHALDRQACKHREGNKRHGNEEMTMCVSVQEAALADLDDIAAILESRDDEVRAWAAAVGVKGAKLNRKLNVALKAVEAVESLKRAVTSARVVADKKKKIKKTRGGNVGSPAATRSRGRRGNKDPEDEIMTTESDTSESEESEEEVMPKKRKRRALADDDDEYEPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD70</accession>
    <name>K1VD70_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD70"/>
    <dbReference type="HOGENOM" id="CLU_1355519_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD70"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="202" mass="21833" checksum="FF80B6E4B3E6BAC0" modified="2012-11-28" version="1">MTSTPPSDASAGKKRLSSNSPPPAKTAKRIRTRTERWERACLPSPKGSTSSPEDTGPPNHRWDEDDFMDMDDHQDLCAAVWGLMEGTDANPIPPPSESTQSTPQHTGAKSTSEDSQPASSSWTDYEWIPFEECNRHLCEKAENVHAPAPNVPPAEPNTDTYQPAGLTENSSPSSFSIIVTPDFGHVSFPHSPGHPVSASLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE69</accession>
    <name>K1VE69_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_03447</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE69"/>
    <dbReference type="FunCoup" id="K1VE69">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VE69"/>
    <dbReference type="eggNOG" id="KOG0026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="InParanoid" id="K1VE69"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="238"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="572"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKD02300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="755" mass="80090" checksum="B3C44E69150D5127" modified="2012-11-28" version="1">MGFTLVIDNYDSFTWNVYADLSVLGGNPLVVRNDKITLDEIKAMYDKGEIDRVVISPGPGHPRTDSGISRDVIQWALGKLPLMGVCMGLECLVDVLGGEIAYAGEIKHGKTSLVKHDAVGCFHGLPPLLASTRYHSLSAKLLSLPSTLKVTSTSEESDVIMGVRHVKYTAEAVQYHPESCMSEGGRGLFANFLKLKGGTWGGENEWCGVPAAGEGEPKPAAVPQPPESVKPKSAPSILNKIYAQRQADVELAERTLATTPANLRNAINLHTAPPLISFVDRIKSTPHTAVMAEIKRASPSKGDIAPNASAPAQALRYAIAGASVISVLTEPTWFKGTLGDMLSVRRAVDSMPNRPAILRKDFILAKYQIDEARLHGADTVLLIVAMLDDAKLKELYDYSVSLGMEPLVEVNSPAELERALVIGSKVIGVNNRNLHDFNVDMSTTSRVNDALKGRDVILCALSGIAGHDDVAKYVEEGVRAVLVGESLMRAKDAGAFLRELIGLPKATEAAPEKPLVKICGVRSAKDAQVAVDAGADLVGIICVPGTKRYVAPEVAREIADTVRRGRKSGSGAKVSSPLWFSANAQRLRARRRPLSVGVFRNQPLDDIIAAVDEIGLDIVQLHGDEPQQWAAQIPVPVIKVFRVSGETIKGGEVSRPGLNDFVLLDAAGASGGAGGGDGVAFDWGVAKRVADEGEVGSEGKARLPLILAGGLTPDTVAQAVMEVGPLCVDVSTGVEAEDGTKDPAKVNAFVKAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEA5</accession>
    <name>K1VEA5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEA5"/>
    <dbReference type="HOGENOM" id="CLU_1385055_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEA5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="197" mass="20919" checksum="A41315A6EF758182" modified="2012-11-28" version="1">MPSARRTSSRRRNTTTQITQAEVMDRIGAVLLQGSEGRQWGNEPMYSGVSWNVILNSVSARADVFAPSPPESSRAAAAAAGVTGTQPGSGEDATGSPQTPSGGGGRGTAQDPPSPHTPQRPSSPSAEDSPHNSPIRRYVDKGKSKAKDVLRQSPVGRFLPRLWQSRTEKKGRKTPSPPHLLDARLRGRLRAIAVIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEP1</accession>
    <name>K1VEP1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEP1"/>
    <dbReference type="FunCoup" id="K1VEP1">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEP1"/>
    <dbReference type="eggNOG" id="KOG1507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038841_1_0_1"/>
    <dbReference type="InParanoid" id="K1VEP1"/>
    <dbReference type="OMA" id="YSGDFMY"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="416" mass="46903" checksum="A3788A9AE1AE5E46" modified="2012-11-28" version="1">MSESQDIKPRAEDDLIAPTPQNTPLNTQVLANRPAGLGKPQVEDVAEDEDEDDAEDVSGVNPASLLASNPALLALAQGKLGSLVGRPSGYIESLPPAVRRRIDGLKGLQVEHSKIESEFQLAILEVEKKFLAKYQPLYDRREAIITGKEEPTEKEVEEGKNADSDDEDEEETEGAQITEVDDDGKEKKDEGADAKGIPEFWLTAMKNSMPLAETITDSDEEALKSLEDIRLSYLDGQAGFCLHFTFAPNDFFEDKELTKTYYYQVGYGGDFVYDKAVGSDIKWKEDKDLTKKIEIKKQRNKTSGRTRVVRKSVPTESFFNFFKPPQPPTREELEEGDVDEEELEELDGRLEIDYQLGEDFKEKIIPRAVDYFTGKALRYEDDFEDEFEDDDEDYEDDDDDEDGAQQGADGQDCKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF85</accession>
    <name>K1VF85_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cap binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF85"/>
    <dbReference type="STRING" id="1220162.K1VF85"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513071_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF85"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="531" mass="58661" checksum="008B6F35D4ADD249" modified="2012-11-28" version="1">MSVPAAVAEVNEKTLSDALAAAKISDSETAAAAEQPEKKEDDLEEGEIKDDGTPKTVFHDAQHFNVKHPLFAKWTLYYDSPQSKHLPKTPQSSISTNTALHGGWLDDIRKVISFDSVEEFWGMYNNIVPPSQLPGKANYYLFKDPENKNGGKWAIQFPREKTKSQIDKIWLYTMLAAIGETFETPLDGGVPENTDLVTGVIMSCRSSFYRISIWTRQACDVTLTEEDPLMKRIMTIGRHFKASVLGYDVDQKLVTGGFQTEVTFESHKDSEKKGNKARITLGPSEDNKEADDKKGTRKIKADLIERAKIKKQYAKVLAETGVKSERLKPQAKGKLGKPEVNRSETWSAVDDDTLKDDENDDGDDSDAESVASDASDASSALGLAGETRDDDSSDDEAAAFAAREKAMLRGKGRPEKGKAAGGKFERKSFDGQRPGAIGKSPRGKGRDRPAPYSKDRPPHMKGGPKGRGKWQEKEKPVRALSPPVLPEAKEGSMRTIKKEGFSKFHRSASGKKQPNMAARMDVLLEKIRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF88</accession>
    <name>K1VF88_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF88"/>
    <dbReference type="STRING" id="1220162.K1VF88"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="InParanoid" id="K1VF88"/>
    <dbReference type="OMA" id="DMPIMLY"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="336" mass="35398" checksum="9E8F2DD911FC79D8" modified="2012-11-28" version="1">MTASSSKVWPNGVSVPLTTPFKADETIDHAALAAQVVRLAQAGVGIVLLGTNGEASHLSAEERKSVVETGRKALDSNGFEGTPLLVGTGGGSAATTIELCKDAASAGATHAIVICPGYFAFAMGRDRQAILDFFNKVMDHSPIPVMIYNFPGAAAGIDLNSDELCALAEHPNCFGAKLTCAMIGKGQRLAAYTQTPEFLAKRGPQLASVTETGAFQVLPGFSESLLPALLAKHHGCITGTGNVFPKTINRLYTQALKGLKGDAKALEEAVRLQDRVARSDFIIVKAGIQGTKHALDHFVQPGLGGTSRLPLGKLTPEVKAMVETELKEDWEFESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFA4</accession>
    <name>K1VFA4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFA4"/>
    <dbReference type="STRING" id="1220162.K1VFA4"/>
    <dbReference type="HOGENOM" id="CLU_809380_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFA4"/>
    <dbReference type="OMA" id="KLENVAW"/>
    <dbReference type="OrthoDB" id="58379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="343" mass="36811" checksum="59C2912EAEA8BEBA" modified="2012-11-28" version="1">MLATIPASTTPTPATAADKGAPPSYDTTMRMSPMVAQPTGPAPVIPSRSSSYSTASSDMFMSSPPSQSITTLSNPSLVSLTPSVAPSQGPCSTMSPMMNRHSFMPAPRRPSSVHPASRPAFAIMTLAEQNVVRTFGFPAKVIEAIDLTLSRGWKGVTRKHSPRPAVQDWELLGAPWEGGIEDVRSRRLVEFLLFSLSKVGWHLSSSCELPGRSRDTLFFKQGPMVARAYFSVGFDDENTHSIKMIDAPNDARQVFLDTLSEFPGGLAGHCVPERGCLEAVLKTDPFNTMADSELGGQLMCALLYALDGIGYELVSSIALGRKPASTPWGAGSSVDTWFLAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFF1</accession>
    <name>K1VFF1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal large subunit assembly and maintenance-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFF1"/>
    <dbReference type="STRING" id="1220162.K1VFF1"/>
    <dbReference type="eggNOG" id="KOG0296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316220_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFF1"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="687"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="834"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="923" mass="98615" checksum="4A1C11A079605BFD" modified="2012-11-28" version="1">MNGSPVPSDKHDRHEDSPEDRDLKRTKVAHEVTTSREGTHGPSTDGHRSPAPSTSRATSVGSPEKPKSDGGSLAKSVVKKNAKSKKAPDSGSRKIGKRSSSKDVVASRDDEDNDDSDGNENVYCVCKGQEEGTMVGCEVCDNWFHPKCVNIDEDKVDLLDVYICEACEPSTSQRTRYKRFCKRDGCERQAAPSSKYALHHEDTADPRYCSSRCALQVAQAVASGLDKKTTSEISRSLSGYPAPAPAVSVQLADGSQPSTVSPSHAALVANLRSQMSELERQMDLVTKRQTLLSQAVESWEALPLVLVEVPARRKNKSKRREMETVEVRPCGWDARLLWDDVAVEAWDGSQGDGALCDGGKRCDRHQGWQKTVAAGLDVEGAVIDMEASIERAERFDEASETGRKASASGSRSQAQVTGVDILSICINMYHDWTGASSLRFLIFHNLIQSTSIIMNPEQQNEPRPDGEDVQLTEDDVVEVVEDDGPAGEPMSDDDFDGYDGEIVIGAPAPGEEEEYMRSIEKGEDMEGVETMEDNSWSASAVHKPQQSLFALALHPAFPNPPIAVSGGEDDMAYIYAPLPPPEGDSDAQGIHADSFSPIGLDGHTDSVVAAAWSFNGEMVATGGMDGHVRVYMKGDDWTQWGLIADLEADSEIQWLRWHPKGPVLAAGCEDSTVWLWQLPSGNTMTVLSGHTMPVTAGEFPPPNGRQLLTASLDSTLILWNPTAGTPMFKLPVFCGENASELDPSVDGITALAVSPNGALAAVGSAGGEVKLISLPKGDIVGKLEGHNEGESVEALVFVDLLGGAGGGKGTVLVSGGVDGKGFVWDVHTGRVRAELKHDEPITSLAAHPAPNLHLVTSGSADRNLKTWDIRTGTLVAEHKGHTGVVNGVCVAPLPASETSPTGQQQAQAVVSAGDEGVSLVFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFL2</accession>
    <name>K1VFL2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFL2"/>
    <dbReference type="FunCoup" id="K1VFL2">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFL2"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_1_0_1"/>
    <dbReference type="InParanoid" id="K1VFL2"/>
    <dbReference type="OMA" id="LYMACRM"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20552">
        <property type="entry name" value="CYCLIN_TFIIB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="228"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="403" mass="42856" checksum="3AC1335FED6CCC74" modified="2012-11-28" version="1">MNGVAGPKAPVGKYGQPIVPDLAVRHLCPNCRTDPPNIIEEYSHGDLTFAGDEGGDDPSRVGGPSNPLLGHAPLETSISGRDGRTGMSRDLQRAQNRANQQATATASGTRSTPAQLQAAFSRINEVCDSMQLPRSIAERAQHAYVIGDEQSVSKGKHPDTIIAACVLFACRAAGAARSFREVGKAVKVPKADLGKVFNELRMVVMAEQQRRGISQPQGFSSASESTEGMLGRFCNYLDLGNTIFNASKHIAVTAVKKSCIDGRSPLSIAAGVLFFTCILFENSSTPKEISGVAGVSESTIKLITKKIAEDVDKVIRPEWKTQYPDGYRNLASLGKAKEKSSRSATPSQPAADKEKKAKDEAKENGSKLKNGTTANGDSNGNEASKKEDVKGDSKADTPEVIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFQ1</accession>
    <name>K1VFQ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFQ1"/>
    <dbReference type="FunCoup" id="K1VFQ1">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFQ1"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_2_1"/>
    <dbReference type="InParanoid" id="K1VFQ1"/>
    <dbReference type="OMA" id="SIAKEPH"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="264"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="351" mass="36913" checksum="9287C2A6C3790CB1" modified="2012-11-28" version="1">MAESDSPPPQALEASPEELTLRSLVSTKEAGIIIGKGGATIANIRQVANCKAGVSKVVPGVQDRVLSVSGDPEAIAAAYAEVARLLLETPLSDSSMPPPPVNQFTSIRLLISHNLMGTVIGRAGVKIKQIQDMSGARMVASKEMLPQSTERVVEVQGAQDAIKTAIFEIAKCLLEDWERNTGTVQYHPGAAGDAGVLAGGLGAQAVTGPTGGIRRTSMGGFGSGSPGPNFNNSDRRVSRGSISGGTSGQERRVSESQPVLNDPNLRTQNISIPSDMVGCIIGRGGTKITEIRRLSGSRISIAKVPHDETGERMFTIVGTAESTERALMLLYSQLESEKERRVNQSIDSADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFZ4</accession>
    <name>K1VFZ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFZ4"/>
    <dbReference type="HOGENOM" id="CLU_1171329_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFZ4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="237" mass="25489" checksum="560C456D5063A888" modified="2012-11-28" version="1">MYGRRANGATRRALSPVVNTDGQAAVHSDMTRDVVALTFSVSSNLFPTGSPRPGTTMLIVFDLVRHSDILKAVLLACSFEPATLNALRLVCTATKQAVVAFHCRAIRLLFVSQGPPSPANINIYLTTLDPLDLPREQMPPYALSPALAFSMRASIPPEAAFGIHPGVALALNHPAYVSVYLTDMHHDHFWSMQASPGQLAYHSPVQLLSHVECLLSIIAARSLSAPSTTPPSTSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG11</accession>
    <name>K1VG11_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG11"/>
    <dbReference type="FunCoup" id="K1VG11">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG11"/>
    <dbReference type="eggNOG" id="KOG4771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078857_1_0_1"/>
    <dbReference type="InParanoid" id="K1VG11"/>
    <dbReference type="OMA" id="MQQTEAD"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="243" mass="27286" checksum="609899987D5A4004" modified="2012-11-28" version="1">MANPRQRAKSRSGKSTKPNLLQKRRLKQKLRKAHPLFGPETLQNAWDRKKTVFQNYAALGLLPSIPLPENANAKVQLPTQSLPEGAPSIGFGRIVRDEEGNVIDIIIDGEEDEKEEKEEDKRWGKPLNPEEDEFEKAPVQAKTQVVRVCRVVPDESRGVISCCWKSKLTPDLEALAATSAPVQRHTSAAEGIWLTRLVHKHGDDFSRAALDRKLNVWQKTPGELKRMVRKAGGVEKLQAQPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGF6</accession>
    <name>K1VGF6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000356">
        <property type="protein sequence ID" value="EKC99915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGF6"/>
    <dbReference type="FunCoup" id="K1VGF6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGF6"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="InParanoid" id="K1VGF6"/>
    <dbReference type="OMA" id="AVEWMEW"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="463" mass="50677" checksum="77981794AFF8894B" modified="2012-11-28" version="1">MSEFKQLPNNIGAYQPGPLPEAPRPMAPFPAQSAEYPTYMPLQAVTIGSELKQEGSERQAQLFKPITIRGVTWPNRMWVAPMCMYSSDDGKATDFHLVHHGSMALRGWGNLMIEATGVVPEGRISPQDMGIWSDEHIAPLKRVVDFVHAQGAKIGIQLAHAGRKASTNAPWVQRLATENGWKGGEVAPSSVGGWPENVTGPSAIPYDDANPDPREASVAYIQSIVEAFGAATERCKKIGFDYIEIHGAHGYWNHNFCDPLSNHRTDAYGGSFEKRTRMSLEVVAEVRRRWSGPLLYRISATDWLEYTGPEKLETPKGEEEWAYWGIEQTTLLAAKLRDAGVDLLDVSSGGNDGRGRIDVRPGYQVPYAEHVKKNVPGLLVGAVGLITDSEQAETILATGQADVVLFGREVLRGVDFPLDAAVKLGVAAAPAVQYERAWGRMLKHVPAVSAVPPVKPLDEQKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI53</accession>
    <name>K1VI53_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI53"/>
    <dbReference type="STRING" id="1220162.K1VI53"/>
    <dbReference type="eggNOG" id="ENOG502S8VS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518941_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI53"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="525" mass="55854" checksum="20DE217254DD6AF6" modified="2012-11-28" version="1">MPPAPGLSPGELDDPWAEASSPSASAAPLSTSPEEEGWGSGPVAGPGPSTTSALEASLRASPAVSSPLSPGGSGLRSRDQGARSPASSSILAPKPRARSGSLLNSLKYSRSTSQPVNLENLQDIDPDVSRPSLKRLKSETERQLWEDSTVSSRGGSFDRERDKEEEVEVIVHQVVPSDSLAGLALRYGIDISTLRKVNKLWPSDPVHVRTSLYVPLDACHPTSGTLVRRTGHVSLVPHRKAGAKSPKRRPPNGDAVSVLSDKTAREVSPEPPERQEVLLGEGEDPLTSTSTPPVEEPGTIVLQVVKLPASKLHHYPNSRRKRATASSGAAPRASMDSDISGLSGVSGLSGGLTTLSLNDAAADGVPRPQSCREDSRLFGLFTTSRSDSGLVPPSRERQKDEGRFAPLMPRVDGFGPDDEPDTFGSKRGKRVVKLRPPVAAPHQGTGLVGRISDFFNPPPPPLNPSPQRPRQVTRIVSEPVSRDSSRSASPAVTSQRNVELDVELDAKPRSLRGSKSRPRSNKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VID6</accession>
    <name>K1VID6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40s ribosomal protein s15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VID6"/>
    <dbReference type="FunCoup" id="K1VID6">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VID6"/>
    <dbReference type="eggNOG" id="KOG0898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_1"/>
    <dbReference type="InParanoid" id="K1VID6"/>
    <dbReference type="OMA" id="CARRRFQ"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="178" mass="19954" checksum="F978AF3D301EED36" modified="2012-11-28" version="1">MAEFTTGEEAAAKKAARSFKKYSYRGVELDQLLDLSNEAFIDVTHSALNIYNHCNLARKLSSPLLPANAQLVHARARRRFQRGLKSRPMRLIKKLRKAKKEAGPNEKPAIVKTHLRDMIIVPEMIGSVVGVYNGKTFTTVEVKPEMTGHYLGEFSITYKPVGHSRGANMANSRFTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJQ4</accession>
    <name>K1VJQ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJQ4"/>
    <dbReference type="HOGENOM" id="CLU_074892_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJQ4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="35462" checksum="E0C495EBDF1F9A33" modified="2012-11-28" version="1">MLGCLQFSEQHHLSLHGRRKLGLECQTHQTQGQQSKNIPSGDAVTSPSSQAMVIGAELTRQFCAGRGEIGSFPPLADTSAVMRDTIHSCSGTPKEVSLSDPKIECAPVIERFLEISAKGKLLNWTNDFKMCETLCDTVAFMRKYDCEGPLAILRMHVLNQLLLKQLAPLYVFMVAAAMDDVELSILAFRHRYDVTYIKAVENQILPAMTGSTRPFDFISFNARGGAGSNSDPDSTWPYQLWAIVPADYLWAATSAWNKTWTSQTVVNTKGNPPCTHGYANYPGYVCATCNQIKAKAKQITDVDIAAEYEKAIGEVKKVKLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK30</accession>
    <name>K1VK30_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK30"/>
    <dbReference type="HOGENOM" id="CLU_091800_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK30"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="83"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="221" mass="25154" checksum="E7E027DD17D45A1A" modified="2012-11-28" version="1">MLPPSVVTTSPPLPPVPTPLSPTSRSSRSPIPTLAPAPVPAPPLLELFEGDDGYPVAEFVNMAEYMMSAHAEYYTTAARRIAYVSNNFSGRARLWFTYILGKSPRPHCLRSWEEFRVALLQYFGDVDPVPHTVLLKLTQEDHETVWYAKEFREKAAVCRVDVNHEYYRRWFVLGLQPAIRDRTLRAFYHLGTFQDVVRHAREIEVALLGLQNSHPSHASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK37</accession>
    <name>K1VK37_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK37"/>
    <dbReference type="STRING" id="1220162.K1VK37"/>
    <dbReference type="eggNOG" id="ENOG502S86U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052897_3_1_1"/>
    <dbReference type="InParanoid" id="K1VK37"/>
    <dbReference type="OMA" id="MISECIA"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="167" mass="17296" checksum="21AF71117F5D29B5" modified="2012-11-28" version="1">MAPVKKATGTTAKKASSHPTFLDMIQEAILAHPEDARSGVSRPTIKKFLATKYNIDLSSASNINNLSNAIKRGADKGVLLLPKGVSGKIKVAAKAKKAAGKENEAPKKEAKKPAAKKPAAKKAAPKKTATKATTKKATTTTKKTAATKAKAPAKKAATTKKTAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK41</accession>
    <name>K1VK41_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_06167</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK41"/>
    <dbReference type="STRING" id="1220162.K1VK41"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011556_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK41"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000398">
        <property type="entry name" value="Calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="14">
        <location>
            <begin position="157"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="958"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC99551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111620" checksum="927F42DD684E3374" modified="2012-11-28" version="1">MAEQLTKEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTQAELEDMINEVDADGNNSIDFAEFMTLMARKMHDTDSEEEIREAFKVFDKNNDGHISAAELKHVMTNLGEKLSDDEITQMIREADKDGDGMIDYNEFVTMMMAKTFRVQEAGEDCFTEGVSLKNHGGGVCVVNNPASRVVSPTMIRATTINTVIYRHLQDLSVLQFRRADAPGSKAHLLLSMTTSALPPAGDYPYLASLNAAQLEGTFHATCARFLRRYGKWIKLDPSFTIADQDDCKKIMKRLLKERSDELQELRLELKEGDVLNRISKAKAKEQSPADMLNALEESSQGDVDVLGRMIVQLYEGYDAALREANALDFDDLLLFGLRLFREHPNVIASCKHILVDEFQDTNTIQYELMVCFAHTGVSIVGDPDQSIYGWRSAEIENLNKMTKDFKGVKAIHLEENYRSTGAILAASHAVVTQVALKTFTNPTLEAGYISSEIKRIVAYTGEMLNYNDFAILRGHKFFERMEIKDLLAYLQLADNPNFNSVAELVSAAKKAKLSMMELAESIVDGESQITIKPALKKNLATFVGIVRKLRRAALKGTSVADLIRLTIEKTNYEEYLRPQPDFDQRWENINYSVTVEEGKEASTDASSRLVSDPVDFVAASEVKAAPKKLETSKAGAKSTMHPMFKNNKPRPTRKSPAVKVENGVVELLDSDDEDLDDGSIEAADPVEDSEQLDFSLLAKYRGARSGRGAEAALRRYDTRPDVPARMAGGEVNNRIISPFVNAVLKKQPDVLTSSLPEITAEVRQAVASIVGRTLADEEVTRKLIANYVRFAPPPSTWDAPDPDSRIYNRFGRRDGPGKMARGIEYWNSEFDDYALPGEGGAPSYNMGAPRGFTSIASAKSLLRQPQAPAAPKPPPVKLKSSNYGLPGPVPFTFGGREEHKPTDLTSFTSSANSGLAAMKSLGMDLGEPDISSKPNSGMSALGGRPAQPPSAGGSVPLARGTKRLGMGRAPSSWGAKKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKZ0</accession>
    <name>K1VKZ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKZ0"/>
    <dbReference type="HOGENOM" id="CLU_729953_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKZ0"/>
    <dbReference type="OrthoDB" id="10656460at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="323" mass="36440" checksum="1932FAB3B9EDAB06" modified="2012-11-28" version="1">MQFSQIGEGAFEISNTLVYSPNTIYENGDFASPCTSGGDTMPILQKLNVTDKVLDQTDKSLNKRLWALYPVDKPLAEIKAVFREAHFKLADWPLATRDDIIKAVPVHDRDQRHQLYILIHAVCQIIEDEALRRVLAPLLDRSSDPKFYNHVEPVREAVPRLNAQKDRANALLRAGQRGSLDKQFEALVLYLQTVLQLAPWHPSPLLFTGKQAHELGVAQLYGSLLSNIALACCLLGKADPRFYRKSMQFASLVIEMRYARHKTLMTAIKTLNNARTELCKETMFMDPGDMPGLVQKALEKMSTKAHDGWAHEKCLTAKHEGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL29</accession>
    <name>K1VL29_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL29"/>
    <dbReference type="STRING" id="1220162.K1VL29"/>
    <dbReference type="eggNOG" id="ENOG502S9QB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_761161_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL29"/>
    <dbReference type="OMA" id="FYDAICA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="365" mass="35234" checksum="47A04CFB1107FA95" modified="2012-11-28" version="1">MASLGPLDALLGNVSAQCKQAALPALLSAQCLHLTALAPILSGSADSDVTPVLDGWIKQICGAAPCQSADLQPLGDQLQPVCGDQHSPIVDTLFSIKDHYGDFYDAICAKKDDGQSCIIEVLQNFAQKTGKTASISFAGSLLNDMNGFMSTAATALADGSMCTPCLGTVFYEGKKFIPLIQNDNTLGTALAGLCEKPDNKPYGGQVGVGVTVPSGEKPKNTGGGSTESASASAPPTSDSASASASASGAPAPSGSASGAPAPSGGSASASGAPAPTGSASGAPKPSGSAAPVPSGKPSNAGPGPASAAHTGPVAPLSKSSDAAPSSSAKAAAGAGADHAKSSAGKVTLKGAVAAAALVGSFVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLK8</accession>
    <name>K1VLK8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLK8"/>
    <dbReference type="FunCoup" id="K1VLK8">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLK8"/>
    <dbReference type="eggNOG" id="KOG0592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290852_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLK8"/>
    <dbReference type="OMA" id="FRGATDY"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="253"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="986" mass="106733" checksum="670653876FDF208D" modified="2012-11-28" version="1">MSAATTTPPTPPTSLPAFARVTSASILQRNASTSSSRSTTTSESTSSLVAVPIRPPPIQTRTTATPEAQLPSEGAPSYDLEPSGGYYGGRGFMHNGPRMARQATMPVHNSLPHLITDDVSMPERSVSVPPNASRSPTTPRASHRSLDTESAPQLPLPVSPGPLSLGYDDSSDSRSEEKSEARSDALTPSRGRQGDSCPPTPSTARSGAHRRDHSADSSTVAPSERTERERRPSHASANSAASSARARPSTRDFILGEELGRGSYSTVVHAVYSPSFLANNPRPANAQFAIKIMNQAHLIQEKKAKYAHIERDALIRLAQPSRNLGVRGHQRGLSSSSGHSGVLRKSGHGAPSVGTSLPTIGVSEVPSSSLVSPTPMSPRMSTSRRLRGDGQEVLDERPPPSVFSSRPPSPVQEEEDGSSDTGNLSESLSSSGGRDTAPEISAGSAGERARTPRKRRQSLAPSERSTRSARSGKSTAGSVVVQQGHPGILTVDFVLEYASNGELAQKIRKFGSLDVNSARYYAALLIDTLDILLDDEMRIKVTDFGSAKILGRNGEKESTSKRSFVGSADYVSPEVLRDEPASFASDIWAFGVVLYDFIYGKSPFRSATEFLTFQKVLKRELSFPEGFDETARDLVELALNLDPTKRPTAQALKSHPFFAGIDWNNLWSIPAPKMHTGITPPVKTLDTVQLSSDAWTVFDEEESEHEVLEESGATPANPREPQYDRVAAAKAVRAVDNQDSSPRSSDDIYQPPRPGWLDEEGVPRQNFREHKARGWSTSSSSSGGRLSGLLETMGINPAYNSPGHRATSNRGGPSRASGRSDDQSLGHSGVYPRSPRSPRSPRMRNPNDAKWGLGVATTDNSRWTPVLFPHERVVLSTPILAKPSNGTLPSFLLPPSKRRQLVLTDFPRLLVIKEDEHTHAPKIKTEFFFVTHPKSIKIAAQLRKDGNGPATGEDDDRPVNVILELHEKGNRMFLLQTVGYSDVHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLT4</accession>
    <name>K1VLT4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding protein Ncp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLT4"/>
    <dbReference type="eggNOG" id="ENOG502SDZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283731_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLT4"/>
    <dbReference type="OMA" id="QYMIVEN"/>
    <dbReference type="OrthoDB" id="3267800at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="956"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1097" mass="117866" checksum="1DFBBC9060F917B0" modified="2012-11-28" version="1">MATATQSRPQGMTSSAPDTKRSTSGGGYNTPGGTRIDGLLTDGDNNSTRSGGYFTPSLGNKLDGTDNDGYYNASGGKSTPNGVDRHNSSQNYQSNSSQNYQNGHHDDDGSLSKGINSIGASGPNGYNRSASYSSNKRPGMNEQPSRSYIKNRDSDNHPGTGTPPGNQGNTTVTTTFVEFDDTTPSVTGGPTATTGATGTSTPGTTGHTGNTGTTSNIGNTGTTGNTRTTGTTGTSTPGQSGTAGGLAVPTTGQSGANTPGARSGQSFQSGTGVMSGPAAGGFFPTGANARGTTPTPQTPQGQGLNNSVNDNYVDRPGNQLHHDDDDVFGVNNANNANNTTNNVITGANGTSGISNRDLGPQETLGNVQKRPQHRHANKSHGSQYMIVENLPRQDSRATTPRPDYTESAAHWDPAAGAVVERSTPQHEYPPHIDHDDHHDQLSPTQDRRGSQQHNGLRNAGAAALGAGAGAAAGQHFANRDQHDHRNNQPYTDSRYHDDGYGNDRSYGTNDRSYGGNDRGDTRGVNFHDGAATGQRLPQTDGRDYSDRQRQSQLPQQRYPDSQQYQDQGRGGPTVAAVGVPGQSGRDNYDQDRRYDSYNDQSSRPRSRQTSFRDRDDYRDVPSRQQSQRDTLPKSHSDRNNLAAAATGAGIGAGVGAGVGSGMRRSASAGSGLIRGNRDRRASGGGGSIGHGSINRPSTADGYRDRDRFRRGNNGYDDRLPPVEDYDEDDEVRGLEPGQIVTPSRQRALQSLSVLVDSIGRVAHAVCENELVGSAARQGARHLQEDVVVPSTADGYRDRDRFRRGNNGYDDRLPPVEDYDEDDEVRGLEPGQIVTPSRQRALQSSTGRGGGGSDYDTASQQPRSRSAFGHRPQPGGQNGYDEFGAEDDGYGRPPTRAGTVRSTRSRRPGTSMSGAPRRGAFGQGAALSTGTNPHDVLSRQDLHERSSLAERALSPNELKRLQGMEKKDAKRLTKLMKEEERAQSKSLHQAIADMKRLTKLQKEAIAAESKSQRNLAKWTSREHKARLHFLKEKERYEAIEAKLRNAENDFEERRDHAYGLTEQVAERNQEIDDMRALKAADDRERAIKRTTLKHPGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLU7</accession>
    <name>K1VLU7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-arabinitol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLU7"/>
    <dbReference type="STRING" id="1220162.K1VLU7"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="K1VLU7"/>
    <dbReference type="OMA" id="GYRICIN"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="362" mass="39994" checksum="044F06D6EC4BC16D" modified="2012-11-28" version="1">MSAAINVHATNLAPTEDKTQNGHSAQEHHDDQEHPPHPDDDKSPEEIRQAYEELRIEVEPTEAMIDPNVQFEHPETFPANDVGHDVLHNVARHNKRTLASFSMTNKVCVVTGAARGLGNMMARTMIESGATQIVILDLRQEECDKAVEDIQEWFEQEVLTPEERKKGLASELECIGVACDVSDEESVQAAFDTVKAKFGRCDCLITAAGIVENFIAEEYPTDKVKKLMDINVMGTWYCALKAKELMEDGGSMIFIGSMSGSPQTPYNFSKAAVRHMARSLAVEWALKKIRVNCISPGYMLTNLTKVILDNDPVLRDTWISKIPVGRMGDPSDLKGAIIYLASDASKYTTGSEMVIDGGYTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM15</accession>
    <name>K1VM15_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein s21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM15"/>
    <dbReference type="FunCoup" id="K1VM15">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM15"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1807589_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM15"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="143" mass="15584" checksum="C59F6BC8DE98F7EA" modified="2012-11-28" version="1">MRLLLRASLPDLASFASCCSSRNRLWRELPSELPRRLSNSLHLPIYSPVGSLGLACALLIAGVLVDLYIPRHCAATGRLITSKDHASVQIMVADVDADGKAIKGKNHTYALCGEVRAMGEADDSLNRLATQDGLLQHVWSYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM55</accession>
    <name>K1VM55_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM55"/>
    <dbReference type="HOGENOM" id="CLU_611376_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM55"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="448" mass="49174" checksum="C25A5724A9CB0981" modified="2012-11-28" version="1">MALRAAIKRAVEKFKLRFGRAKDGGYERIGLNDDQSSATSHRSSAQARSSVDIGDVFGSAPPVSTSVTDGDHDLQSPINATSAPVSSGPRSAHSASAHSHDEKGNQSSDSSTVTETRQATIHLPSYRRQYTSQPTPSVPQEHQKLRKLPVRKDTIAKSLMKEKLSLLTEEIRGAVLDATPSSMLAEVQVELRTKAWTQVLLESAPVDPESRPLCLIQTLSTNEEEFLPDSDIHNLIDSTLKELGDAMVDAARRQYGSKLYITIKAILHITASVQVLVEDDAETTQLAGSMSAYPVREWAVSVASHASHDAHEALGLSRFEDLVSELHPLTKSKLLRDLVFVVYGGYTWTNSTRTIWFKSIDRHPFSYARILSPGYDCPRGVDAPLHWTHSPDDAACPCVDREAETVYAIRPWCVNEDGGFDGSFNPDRDAVRVGPLKDFMPAFAALPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM74</accession>
    <name>K1VM74_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM74"/>
    <dbReference type="HOGENOM" id="CLU_980675_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM74"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="284" mass="31830" checksum="BB30672866E87EA0" modified="2012-11-28" version="1">MLDLAIDIIQLLLSSTIVVASIAYMRLADVRGYKCSQSALLGFNLPWFIGLAVADAFSLAYTWKVRKVREQQRRWLQQLARLTRLGAGVGAAGEEPGNFVPPRRPHRRSVSGKDATTCNTRKARCLRQPEILTLELILLLMTWVYLGNTCAVRPAIKHYIKQWRPAIVPRLPVACAPSTSGYPFVQRVCYVPSDSKYSACNLPHPPIELDADSAMCSVCFDDFEGPESHVKRRLLRKQGPVTAPTLWKTRCGHVFHEKCLLEWFKTSRGSICPYCNQDAAAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM94</accession>
    <name>K1VM94_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM94"/>
    <dbReference type="STRING" id="1220162.K1VM94"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311958_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM94"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="399"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="PUB" evidence="8">
        <location>
            <begin position="686"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="621"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="827"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="880"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="941" mass="103640" checksum="1DC8F13E1FCC9DB5" modified="2012-11-28" version="1">MDPNAEGGPPKAEIEIAEVESDAPPAPPKADIEIKAEQPAQAQPSPEVSDEEKKRIERLERKMRKQERKERRERKEARAQKRQEKQERRERREREKQEAAQAAQAAQTAESAAQPAAESAPEVTQPETQAAPAQPKPDPEVQAAIKIQQFHEEEFQRRLRGEYQAQQLRTGQVPLRLTSIRLSPPPPTTRGDFLSGLLAPFLSEAHPWLKWLHPVPPPPTNLREILQTTKALVQHVDDLGVFDMDRVGIRLEPAPSGDPDEVELLLALRERGRFFLKAGTEFGGNEGGANITGRIRNVLGGGETLEANAALGTKTKSAYQATLSTPVFSSPYLSASLSGFSLDRDNTAFASHRELQQGGRVKLSGLTPLGAHELAYEYVQRDISHLSPKASVSALGLGTSGRLLKLTNEYAGLPGSSELAHFIKSTGVAQASRPLYEGSDILVSVSGFGSILYPLWAPGGFDEPRRTYLADRTYLGGPNSVRGWKVGGLGLSDKLDSLGGDLAYALGISAFLPIPGKEHWPLKIHTFLNAGKVSRYEQQHAEQASVISDRTLTPSSRPVLVPLPLRCPAIVIPRPSSHKFAHTDHLPPFLSCLPIISDLSNSMADPAADARARRLAAIEARLNPPKEDDGAAAAAGSSGSNTPGREPPRNMPKPWTRPSEREQNEKKRELTRLLNRTIVRDSGYRQAAECVETLVKIATNIQTNEDPKYRTLRAENSLLKNKVLAVPGGRDYMIQMGFHTENKDFTQFFILDQSEKRLWQLGLAADVLREALPELQKRVSGTTTSTANAKAEEERRVAAAKRQIEADRELVKQRVERERIVREAREAARAKAEAEPQPQEEPHFHVRGQGRKLDGSASTEGVGSPQARSRSSQAAQQVGPDDDTDMIPSDHEEDDEEGEDDGEETDEEEREFRRQDAQNRMGMFGMASNAHHWGGGQKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMD5</accession>
    <name>K1VMD5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chloride channel, Gef1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMD5"/>
    <dbReference type="STRING" id="1220162.K1VMD5"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_1_1"/>
    <dbReference type="InParanoid" id="K1VMD5"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="393" mass="43241" checksum="503A7FAD4E53D847" modified="2012-11-28" version="1">MSYPPSNQPDNAPGDSREASFTPAVAQVPDEIELDQISTVDWIQDSLRDRNPKTYLPKPGSVLERLENLEGAPGAVWRGLRRAFREGESYVVLTLVGAIIGVISALMSILTGWLADYRLGHCTNGWYLGRKFCCLEIAEDGGCDEWHDWGSFPPLPWLAYIFFAPLSIGSGLAVGKEGPSVHVASCVGNVVGRLFPRYKASHSVAVAFGSPIGGVLFSIEEMNQTFSVRTMWRSFVCALSMDPFRTGKLVLFQVSYDRDWHYFEIPAYILLGIFGMAAFRRKHLANRGVAEAVTLAVLTAVISYLNRFLRIDMTEMMSILFRECEGGGDHDGLCQASSQWSMVWSLLLATVLRIGFIIISYGSKVPAGIFVPSMAVGATFGRAVGIIMKAMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMF1</accession>
    <name>K1VMF1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NAT10</name>
        <name evidence="16" type="ORF">A1Q2_07694</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMF1"/>
    <dbReference type="FunCoup" id="K1VMF1">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMF1"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMF1"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="12">
        <location>
            <begin position="275"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="526"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="15">
        <location>
            <begin position="759"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="628"/>
            <end position="630"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="635"/>
            <end position="641"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114268" checksum="4D2970F42D965497" modified="2012-11-28" version="1">MRKQLDPRIPALINHGVKTNHRSFFVLVGDRGRDQVSCRGVCPSAELTIPGCQPALPALAGSHRKKREAKIKRDIKRGIREANEQDPFELFITVTDIRYAYYKDSAKILGQTYGMLVLQDYEAITPNLLARTIETVEGGGIVVLLLKTMSSLKQLYTMAMDVHNRYRTDAHQFVQPRFNERFILSLGSNPDCLVLDDELNVLPLSKGKDIVASKEDDDRGRKRKIEELKDMKEELGTVDIVGPLAKLTKTVDQAKALLTFVEAISDKTLSSTVALTAGRGRGKSAALGIAVGAAIAHDYSNIFVTSPDPENLKTFFEFVFKALDALGYEEHGDYDIVQSTNPEFKKAIVRVNIFRGHRQTIQYISPEDAHVLGQAELVIIDEAAAIPLPLVRKLIGPYLVFMASTINGYEGTGRSLSIKLIQQLREQSRPAAINSKAEKGESKAGSAGRGGAGLSRTLREIKLDEPIRYAPGDEVESWLNRLLCLDATVVSKAAQGCPHPSQCELYYVNRDTLFSYHAASEVFLQRMMALYVASHYKNSPNDLQMLSDAPAHHLFVLLPPLKEDDNSLPDPLVVLQVALEGNISREAILKQLAHSGSSASGDMIPWVMSQQFQDNDFAMLSGARVVRIATHPDYSRMGYGARALDALNGYYSGELTNLDEVLETPEYSAPKMNGELSTETIAVRDVARMPPLLQRLSDRRPEVLDYLGVSFGLTPELLRFWKKAGYVPLYASQKENPLTGEYTFLMLRALRSNVATAQWLPAFATDFRHRFIALLGYDCFKKFPSQVALSVIDAASRKDEEVQAISAAELNALITPFDLKRLSSYADQMVDYHLILDLIPTIARLFFTRQLPTTLSPAQQVVLLSLGLQRKPVESLETELGTPAHQVLALFGKTIRRIVKVLQDIQKAELGADLPTEEQAEAAAKAKTSGPAATTVDQDIAEAASEEKQRQRELLDTIDMSEYAIDQGADFSSAAEKVRALAEATPEQRKKMNTTVTVKGTAPVEEKKETKEKRKENGGDKGNKRKKHKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMH4</accession>
    <name>K1VMH4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translational regulator GCN20-like ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000093">
        <property type="protein sequence ID" value="EKD05390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMH4"/>
    <dbReference type="FunCoup" id="K1VMH4">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMH4"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="K1VMH4"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="232"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="449" mass="50081" checksum="AC1602B9789AF574" modified="2012-11-28" version="1">MERDGPGTDAEAVRVEFEREKDDLATRLGEIQRSLVEMEAETGPARAGALLAGLGFSEEDQQKPTSSFSGGWRMRLALARALFVKPDVLMLDEPSNMLDLNAIAWLEDYLQTWPGTILVVSHDRAFLDAVATDIVHQHSQRLDYYKGNFTNFYATKTERALAQRKEYEAQLAYRQHLQAYIDRWRYNANRAQQAQSRIKILEKLPDLEPPEEDDANEKFKFPDPDKISPPLLQLDEATFGYSPDKLILKDVNMNVDLDSRHAIIGPNGAGKSTLIKLLTGVLQPSKGNATINSRCRVGYFTQHHMDQLDLNVSSVQFMQSKFPGKTEQEYRSHLGQFGITGLTGLQKIGTLSGGQKSRVAFAVLAWGNPHVLLLDEPTNHLDAEGLDGLAEAVKAFKGGVILISHDERFINATANQLWVCADGTLTKFKGDVAAYKSLIVNQIRAKTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMP0</accession>
    <name>K1VMP0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMP0"/>
    <dbReference type="HOGENOM" id="CLU_1807586_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMP0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852268" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17367" checksum="A6F4D4DBEC3BA97E" modified="2012-11-28" version="1">MEFPKSALLILAGWFAMLAPSAHAWLWGWPGEWTISYFEGGYIACDGHGQNVCPQTTGFDKCSPRLQEFRGDTGNNEMTWWTYDFNWGTMRKENSAWIDMWKASDGRWNLYESNRDGHVHGQCERWAKIGECGGKDKHMPHTVFHCWQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMX3</accession>
    <name>K1VMX3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMX3"/>
    <dbReference type="STRING" id="1220162.K1VMX3"/>
    <dbReference type="eggNOG" id="ENOG502RSAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293048_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMX3"/>
    <dbReference type="OMA" id="FAWIDIP"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113336" checksum="C018E436B822FC81" modified="2012-11-28" version="1">MSFPSDQRRYSIGASLTGSPPKHPTILPPAAVRASARVSLCTAPQNKFRIVAESADGALFCVDEMSSAPSSPSPIDGDAKLPRIDTSYADEVDMDDWARTPLPDRRKLHHSLWPETPGRTPRTPDISPPPSRPPPGPPPTIPLPLPPRPLPRRPLPSQPQSRRDSYKTHSRSFSDSISSSSSARALPPPPLDLSGAKALQAMQKQQQQQHRQRVVEADRVEHIVHQQTQEKLERSERVERHYQHLRGASLSSIPRHPFAVPSASYAQNNQSARSTSSQTTQSTQSQVSEIKRSGSRLQRVGRIPAQATPTTTPEATVPPRVLPAPTPATTVTAATVETEPEEEEEIHFGTTVQRAQSVSRAHPAILVDLAGFASDDSHASHRYAYHDPEGLRLSHGSFGPRTKVNSKASGSAASFSPLSHRTTPRSSPSELDVSGSNGNTAPLTMRSPEKAEAYVSPHRRAGAITPSHAPTQSQLLRAIEAQINDSRPVDFTPAPSPISRRTTRVRGPLVPLRPGVPSTHPLPPDLPPSPKVKGKYPAPIAEAMLALIGRRNHVVQMQEVELRKQSADDSSVVELGDAAGDSELAERQWKERERKWKEAERKEKERREAERKEKYTFKPPRGLLPSVVPAPSGPPQRPPRSPLRLSINAPPRPPRSDLRPEHRPELRPMVPSPQTPGVMHDIALTPVAVDFSQPRPYSLSSPRPKKTRSWYAPLKRLSNRGDWAGAKPVKLGSRVDLYEPSDKSSKGSKVTLEIPQGSTTALPPKSPGLTPRNTAHARLAAAEAGFLPSLARRRASKLPTDDKKRKKRLMIGLGVAVLIVIVVLTSVLIAKNKQRGGQPASESEEGERKQQEEQEAQKVRDKGLECARSWVKGDNASFDCNVCYDPLSQLPNDYVNATAGVIGVGEALQYCTLMNIWDRVEDDKDLKKWGETQSPCRWTGVGCDGLGRVTALELRGSSVPESMPDLRHLVSLQSIRLNGNSSAPSGTLDLSELANLTLVNAEWTLLEKLKVGNASSVVLIHNEKLALPDLSNTTVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMX6</accession>
    <name>K1VMX6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMX6"/>
    <dbReference type="eggNOG" id="ENOG502RB8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1035066_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMX6"/>
    <dbReference type="OrthoDB" id="10644136at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="269" mass="28183" checksum="B5CDD251876B4181" modified="2012-11-28" version="1">MGGSNNNNKGKAPKVHAGESFADAVREGTPADPNGDQNARLKPGETYADAVQEGLPENHSSSSDAPPAYSANGAKASDSKTPSSTAQAQSQGGSSSQNSKNHALHLPNAHHSHRLGSPSPSPSPGGHRHGHHSHPHSHHFSTGGGGGGSGGIFAAQFGPGGAEEGVVMVPEREYIYALMRARRRFWATLFWALLIYLVAGAIVGGGVADANSHKGKHKDKNGKWHDHAAAVTEEKGEPLAFVRVGVPADRSQEVDMPWDYRVQDVTAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP43</accession>
    <name>K1VP43_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP43"/>
    <dbReference type="HOGENOM" id="CLU_924981_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP43"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="30348" checksum="136DA321D3C36D0D" modified="2012-11-28" version="1">MSDPPQDTTVGLLTDDVLLAGSPELMLSSRGRPSLPRNQRGCVEPHADLLAIHAGCVSITIAALTSVLSTTLASDRLVRRQFGDHLGYNGNVTWPIQTIPYEEDVPANCSTPCNAWKEATRKGACAIPLPSSLPPAAQTSALPDGSKLSTCPIWTMRNEDVCAVLDVQAQCILCAFPELNQTAPEYVASYGGVVKDCQEQGFRLPESVPGINMQDPTSGAGEQPAEANAGTPWDQVYNPPPANTPAVAAAQSPSSSSAAAPSATTTSGAARLWSHHVLALGLTALSIVAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP79</accession>
    <name>K1VP79_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Negative regulation of transcription from Pol III promoter-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000388">
        <property type="protein sequence ID" value="EKC98512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP79"/>
    <dbReference type="STRING" id="1220162.K1VP79"/>
    <dbReference type="eggNOG" id="KOG3104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487458_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP79"/>
    <dbReference type="OMA" id="MVINARA"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="516" mass="55969" checksum="0ED4F8C5E0239771" modified="2012-11-28" version="1">MKYLDYPVLTHLSEVLSDNPSPEARINVRVEAYSIKPVAKERKMFKEMEEAYVSGQEEMEEMSFSPEMKEAGLSSCFGRLDVKESRKVHFLLVSTLNTAFPDNDFSGLRPDHFMREISAGQVLSHLSNNLLGINAVDLSPLSAAHANAPLPQQSSPPGSAAPLSSSASAAGSSPPLSGDIGNPSFYRLLNDILPLQDCEVYSWFPEPEYDPHVDPEENEEASEYDDEDSDEMIGNMDMDIDIDGEGAYVSWGQAGMDLELDGPSGSSGQRPRSLSRNAIDDLEMGSPYLSAQDFPAVRKVGGLLWSANYFFYSKRQKRVLFITTWARKRPSHEGAPIDKTLAGSLPLPISASLTPPTAGFAGGHGFTPRSPKTKRHHNLSNARPSHRRAKMAKLAQGKTLQTSTIPIRGLGLSTSTPAPTTPTAARMAASAPATSASGILSPASVASPGAMTRMSGSLRPRQTTARMLINAAQQQQQHQQKQPDRERDRTRKERSGSLTPGPPFVPVAEGGKRVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPA9</accession>
    <name>K1VPA9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPA9"/>
    <dbReference type="FunCoup" id="K1VPA9">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPA9"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="InParanoid" id="K1VPA9"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000052">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="382"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="554"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="704" mass="77697" checksum="4CEF71FEBC582C4F" modified="2012-11-28" version="1">MCGIFAYCSYLTERDRKYVCDVLCNALARMEYRGYDSAGIGVDGDAPTDPIVLFKEVGKVAALRKHVAGGVPTTPPGGAEITEKIDMNKVFVSQTSMAHTRWATHGVPTTDNCHPHVSDPLTEFSVVHNGIITNYKELKLVLQKRGYAFRTDTDTECVAILCKYVWDSQPNKRLNFQSLVKTVLKELEGSFAFVFKSRHFPDEIIAARRGSPLLIGVKSERKLKVDFVDVELPQDDMIPEAAQADGLLGVPNAVTGSSKIRRQQSRAFLSEDGIPQPIEFFVASDPAAIIEHTKRVLYLEDDDIAHIAEGELHIHRLRRDDGLSSVRAIETLEIELAEIMKGQYDHFMQKEIYEQPESVVNTMRGRVNFDNSTITLGGLKAYLPVIRRGRRLLFVACGTSYHSCIAVRPVFEELTEIPVAVELASDFLDRRTPVFRDDVAIFVSQSGETADTILGMRYCLERGALCIGVVNVVGSTLSRETHAGVHINAGPEIGVASTKAYTSQYIALVMMAVQLASDSISKSERRKEIIDGLHEIPSQIKTILALDKSLQQLVKESLVNEKSLLIMGRGYQFATCLEGALKIKEVSYMHSEGILAGELKHGPLALIDEHLPVIFIMTKDSLYPKTASALAQVTARKGRPIVICNDGDTSLPESTKVVKVPATVDCLQGLLNVIPLQLISYHLATMKGIDVDFPRNLAKSVTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ44</accession>
    <name>K1VQ44_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Barwin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000380">
        <property type="protein sequence ID" value="EKC98822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ44"/>
    <dbReference type="STRING" id="1220162.K1VQ44"/>
    <dbReference type="eggNOG" id="ENOG502SBZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700548_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ44"/>
    <dbReference type="OMA" id="DCEDSAG"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001153">
        <property type="entry name" value="Barwin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00967">
        <property type="entry name" value="Barwin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852027" description="Barwin domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Barwin" evidence="4">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="408" mass="42761" checksum="2ACDF868E3228B76" modified="2012-11-28" version="1">MFTLVKTALISTLLGSSWAAPIPVHLLPRQGCSAEGGHCATYYDVGLGACGNYNSDSEWVVAMNHVEWDGGSHCGRMVQITANTGKTATARIVDLCPGCGVGSLDLSRPVFEAISNDGLTPGVIPISWQFADGGSSNSGNNGAAGGAVAFDREPAPEPSQPAWTPDSSTAQQAAWTPDSSTAEQPAWTPSPAAEQPAWTPSPAAEQPAWTPSSSSEQPAWSEPAQAWTPTSSTAAAQSSTPTSTEEWSQPSADAWSQPPAESSAPTSTEWTEPAATSSEAWGWRNHNDNKKHGKHGGERGGKHGDGQGEWHGKHDWNRQESTSTSEWAAPTPTAAGEWNPPAALYAEPAPSSVQAEQPGAQPTTPAEQEALPEPVQKEHDAEPGADVDEDDYDCEDSAGSESDLPWCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQN9</accession>
    <name>K1VQN9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQN9"/>
    <dbReference type="HOGENOM" id="CLU_060398_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQN9"/>
    <dbReference type="OrthoDB" id="10671669at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="386" mass="42092" checksum="F880659018A3BC2E" modified="2012-11-28" version="1">MAGWLANIALAPTRRWVVDTGYPVEVVSDSCPRRLRVGKRALTRLLSYSHLSHTTRTRLSQINADAESADSETDNSTDIDRPGPHIRTAGHPRPPLTHPHDMGNNASRPGVPGRRRSAPAGTGEEPTMPPLEHSQSEQPYRDDDAASIAPSFAGTLASIFSERTAVSERTMLDNASLYSSTGTVLDEAIVPPSDAIRDGMASAMEALNGEKGWPATVATAQLEWLAQDAGRRARWLRAEVAMQQRRAKRNKRGMARRHSGGKQQVFNLSLAGEERAKEEDAAVVRRLAMERMAGQHRTRSEELAKEMLEQALAENPLHPPEARDQYHATCKEAADAHATALRNADIAHGKAYSAAKVRYMGATLRAPDLPTGGTSMRQASVGPIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQV7</accession>
    <name>K1VQV7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD03006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQV7"/>
    <dbReference type="STRING" id="1220162.K1VQV7"/>
    <dbReference type="eggNOG" id="KOG3743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299008_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQV7"/>
    <dbReference type="OMA" id="FRFHVIS"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="114"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="354"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="935"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="972"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1004" mass="107303" checksum="EF481FDD22BED6E9" modified="2012-11-28" version="1">MSDLPLLDDNPSTTPLDLLLNAISGTSNLFPQAGASADDPDYLGENGGEGNASTTNDGAENGAASGNDAGDDLSKKRVRDDEDGSGEGPHRLSKITRTLSSHFGKNTRGRAFTTVEVWHPKTGQKSYGKERRTHPNPDPPTGSITFSSQSHRLALNDVPAEESSLPKTKKAERDEKRRQMRQAASRTGWGGSLPWERSRSDTRDRSELTTGLTFPGLWIGEETGKNKEFRLELSVGTPGVENDPAAAVPAENKDVEPIDEAALRRVLAAGVEPLMGLEAEDSKDRLVELEPSMEQTLDSATETQQTEQNETQTQTQQQTQPPEPPKPWATFVSEPLTIVSKPSQKTAKARSMASCLSTADAFALYVRVNAQTVRTKYMKMDEVDGAPILTARTGKWSPFRFHVISRASPPEPEDKSSRARFKLDNDREASIITYGSIVQLVDVNSGIRSDPVRLVRVDKNEAIVGEDEGHPVSELQRIGLVRVVDGVDDETGGARWYLSAPGAVAGAGEVGVTRARPGSRNAIKDAAGNPESVPETLGGLDSLDNGADSTTNTPVSESKRKRKTKRHSLARAAINEEESGSAAAGLVWHQAKRRQGTHIVTEGKVATARPASIETVDDWMSWTLGGVWCFSYSFFNGLGDAEALPKAALDPVPRLLVDPVFKPDQNTLDLTLSYFFIDNDQAQPQPLSLYIGPIGPLRVTTWRSVAPKEKYFDPGALYPAVPYNGSDEEPPLPEGERVYSNFPFNIPHTIAKVELPGMEEIVRVMKECAKGEAATPEPTAVEQPAGEQAPVVGSSEQQQPETGDQTNADDAWLGAMGPAGELTIQEALQNAGKNHAPEHNISEVLGSHVGSAEIPKVGDEEFKFEQLPNTLIDGSLEEAAAEAAASGENDVFSAPGTLQLHKPEVAPKKLLASLPLLLVRPDGVGYGLGWSLEAERGSQGDETEGAGQGGASAVGSSGSGTDNRESSSLPSGSGGNTSAGIGSGAPWGLRVVQTSARGQSLRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR36</accession>
    <name>K1VR36_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR36"/>
    <dbReference type="STRING" id="1220162.K1VR36"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023753_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR36"/>
    <dbReference type="OMA" id="YERENMC"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852392" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="39"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="517" mass="57014" checksum="039FBF53366B2C38" modified="2012-11-28" version="1">MFSPVLLSLALAAPALAADTVANQFILGDNGFLMYGRNDPIISPGQVGQHVHQFIGASNIRDVLNTPAEQRNAVCSSTKVSVDKSSYWTPTLYYMWSNGTYSPLTSNTRVYYTVDKSENGVTPSPFPEGLRMVSGLATFRDEGAEQTVGVRLQYNRENGENERFMARKRATPPNQVIASITFPRCGRADQALDSDDHFSHMAHPIFGQLNEWAVNSRKCPDTHPVWYPQVLIETLFDLTDAMKADWNPNDSNFIISNGDVTGVTWHGDFVNGWDSQVLADTINQCGGVGDNLQACAPLRPHLQGDERYNCRLQGQILNEDMGFLRPLSALPGCNPKWDWEGPTSKPNACPAGHRDPGWVDPQFALISFYSQAFPLAVPGYTGNLSDVHLPDYETASRGYDVRTTQWGRTINHHSHTSANTEAIEYVRPESTQQEIDGNNGGAHPIVNKLGDSSAFSATSSGQRLSLISDQGASDGGHYERENMCWARPKLDWNPVPCGEFNRTGSPTKRAHARDFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRU2</accession>
    <name>K1VRU2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRU2"/>
    <dbReference type="STRING" id="1220162.K1VRU2"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_1"/>
    <dbReference type="InParanoid" id="K1VRU2"/>
    <dbReference type="OMA" id="KNIMQNC"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="578" mass="65508" checksum="94F04105FF1CEDD0" modified="2012-11-28" version="1">MAEEQKTTVNGINVEQLIQESHDPDTPHKHKKGQWYQGWSMYDIPYASRYDVQVNIPADDLPKDGVESNVVYQMLHDELTLDGNPNLNLASFVHTWVPDAAIWVLVGSHMGVGGKQEKQSGRRWRKGGELTHAECTRLMTENLTKNLVDQDEYPACTEIHNRCISMISGLWNHPKNATPMGTATTGSSEAIMLGGMSMKRRWQEKMKKAGKDIHNPGPNIIMGAEAQVALEKFARYFEVEARLVPITEESHYVLDPEKVLDYCDENTIGIFVILGSTYSGEFENVKAIADKLDEYEKKTGIHIPIHVDAASGGFVAPFVYPDLEWDFRIPRVCSINASGHKYGMSTVGVGWCIWRSDKYLPKEMIFELHYLGETDYSFNLNFSRPAHPILGQMFCFLNLGFSGYRRVIHADLTKARILSRALEKSGLFTILSEIHIPVDNPKTKDDTDPTYYRPGLPVVSFRFTDEIKAKYPHVQQRWVQEQLRAIGWIVPNYALPPACEKTEILRVVVRESLSGDLERKLITDIIKVTEGLLKGEGPSYPMSQATKSPPHATRPRRTENHKDHEKISKHTKAHNHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRU5</accession>
    <name>K1VRU5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRU5"/>
    <dbReference type="FunCoup" id="K1VRU5">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRU5"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855773_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRU5"/>
    <dbReference type="OMA" id="CWEIVEV"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="34632" checksum="7DAD682FDB64E518" modified="2012-11-28" version="1">MSLRGVSLLRSARRVTSIRSTTGPLRTLGALGATRSHTTRDRYFLKPLKETEPEPNYEYRFLAEPATVEILSYAFSGGQPRAGVDQGPGALIKAGLPAQLEKLGWYVEHNPTLEAEIAELTNKTEEEDKAIGKLRKPVSVSAVNERLADDVARVAGEGKLPLTLGGDHSLRQPARLPYLLPSRPRGHRHPALQHLAAAVSASRGPVSLPDRLVANASVYIGLRDIDAGEKHILKSLGIKVFTMHDVDRHGIGKVVDMALAHVGAARPIHLSFDVDALDPTVAPSTGTPVRGGLTFREGGEPDAGGRGVGGADDRGWMFARAGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRW9</accession>
    <name>K1VRW9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRW9"/>
    <dbReference type="HOGENOM" id="CLU_719996_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRW9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="384" mass="42956" checksum="CB141019DC75F6E8" modified="2012-11-28" version="1">MTSPTPADPSSKAAARSKRQRSTPPSSPRHTVLPPSPTKSPAVRKPPRKRPIAESKINAGSNDALQPAPDIVLTPRKQRNLRQLVLTARDTYLQFSEFWDSMGLPSVDSDWDEDLDEADEDEEDHGETGTSEDDLVAVDDVNEDGQVYDEDGQADDEDELPQEDDEHAVANEDELEAEEKNDSAEGTGLSTAPVPRQFRIPELSLPAPYVRCLIESLNSLIDGTYEFKVNRKDALVRWKFDFEVLDTIADFANLKHTPSAVSLPVPRSMMTIAFKRGLTVRVLLTDLEGGNLWRAAPLRADKIRVTIKSVNTDKIYFTYTEENLPDTAYNQWWFFLMFLDVAARYKADEEGLQKVRKRAESKAAGQALARALPYKNGKLKGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS85</accession>
    <name>K1VS85_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS85"/>
    <dbReference type="HOGENOM" id="CLU_1826646_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS85"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="141" mass="16311" checksum="30D984C82EC1A4BC" modified="2012-11-28" version="1">MGSAQSFHRKLVVYIDDPIIVDDVSILVQSDQDWTALFEAQHVAGRLDCLNDIMARKSFLFNRGPERWTGKNRALTAAVKDYVLRHHTWCEEMLARGKRHINGEVQPPMVPFFFGNVLDRKARLAGSEDFRDPMRRRPASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTA5</accession>
    <name>K1VTA5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTA5"/>
    <dbReference type="HOGENOM" id="CLU_167047_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTA5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013379696" evidence="2">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="119" mass="12868" checksum="D24946ED269CFDDB" modified="2012-11-28" version="1">MLILRLAALASLTAAVPLPNPKPDPLPEPAPLKVSHTWAMDESAPDSTDGEAAPAGPENAGWMFDWNKLLDWFRSHSSEVDAGQSLSLLALIACRRVLLPVLCLPLSSRPHAKFCYAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTH4</accession>
    <name>K1VTH4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTH4"/>
    <dbReference type="STRING" id="1220162.K1VTH4"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="InParanoid" id="K1VTH4"/>
    <dbReference type="OMA" id="VMDVTNK"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32307" checksum="469B8B15AB8556EA" modified="2012-11-28" version="1">MPVDENDKSAGETELISQVQGGKLKVDNLFNVDGWVAVATLAENGARVYISGRRGEVLKKAAELGKPTSGKGEIIPVEADCSTKDGIQKLVKAVSAKEKQLNVLINNHGVSMPKPNINVEQTPEALSKEMFENEEMDRFLQTYQINTASYYFTAWAFLPLLSASKEPWGEPGSILNIASMSGITYTSQKGQFNYNASKAATISLTNQLACEFARRDLGVRVNSINPGYFPSGMTKFTTDSSDASEREYFRKTMGTPLARAGQATDHAQAVLAAVCNRFMTGCNLVVDGGWLLEQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTJ3</accession>
    <name>K1VTJ3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTJ3"/>
    <dbReference type="STRING" id="1220162.K1VTJ3"/>
    <dbReference type="eggNOG" id="ENOG502S0D7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395973_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTJ3"/>
    <dbReference type="OMA" id="THGRPSM"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="369"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="708" mass="78093" checksum="24E320851E1EC9C3" modified="2012-11-28" version="1">MSSTPDSQAAPVKKRKRTSQACRPCRAKKTKVSTSYLPSTIQDDAPSSNCLPEPIPDSSVTASIRNARHASTVAAGQVLVSQDYLKALEDRIMNLERDRSAPPAPRAHAPTPRSTQMTVPSPLGAYDPPSGSSSNPHAASNGTVRAGHGSGPVDQIQSFDSPPPSNAIDGMGLLLAPQRETPRAEPSGLGFGLAESEVYGAMSGISFHHMLLERLLPGYWCLAPRANAAPRPDVGFLGVAPTPEVFYADRTNLPTRAQAQRMFDWFEAYTWRVYPFIDMKALRNSYDLLLAADDAALRAPENQPIICLHFVVFAIVDSISDDEYTPCNVGYVALRMLRKHQDWPHSTTKVQALLSGAMLMQGIDHPGFSWDLLGYAIRAGYAVGLHDAETGRRFPPMEREMRNRAWWACYTFDRLVTVSIARPSAITNDGCTIPLPEIMEGEPAASIEFFRDSIRLHQALADVVRNPPVSFRHASPAFVRNVVSQTHSLEQAYAEWCDTAHLSDAGHEDPRLATVLTLRGLTMRLLLHRRVMLAAIHDYIPGGARHGQVAAETSLQHLEARHRDLAFGISLGIIVETAIHTINILDHGHADASLSAPWYQLFYAMNAFTSLLATLLLDLSQWSWFIRVPGLPIVQALHSSMRVVRKISDRFQRPSAKQAVVMIENVLTTLGIADPSQQQEQAPSLQDLPQLDIDELWQSLELQIPEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUB9</accession>
    <name>K1VUB9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUB9"/>
    <dbReference type="HOGENOM" id="CLU_1125206_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUB9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="247" mass="26547" checksum="C8CEE1A231611A42" modified="2012-11-28" version="1">MTTAAFPVSSISRAWDASSVTLCSPPRRRRKAMGPGTIRAAMTGELPDPEATVRVPPPPTTKGYYAKDAVEDYDCGAVEEIAIDEYASPSSDSDSTRSSRSDGDGIVIGPALLPVFRATAFGMQLDGRVLPSHVVRRHRTALFITPQPRTLCPVTGALLLDVQLYNLAVLDLLVAGGHLSRPLALVTVFRRASLRLVELLRRLGEAYALAGRYDEGANEELERLKAGTLLLAGKVCQTAQKVMMVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUH3</accession>
    <name>K1VUH3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUH3"/>
    <dbReference type="HOGENOM" id="CLU_960389_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUH3"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="31156" checksum="3EEC02EB12DB35FB" modified="2012-11-28" version="1">MTSFENFTFTFSFLHVGRPTKAIDHHSFPHIVDLIFEFANFDTLLLLGQVCREWRSRVDAELYHLHDFRASSRYDSKQQGDDWWKHPKYDYYFETASGKPGKLPDVTRLSGTTKIIDLSYRAMSYGADTRAPIDAMRLPEPRWEVESDLFRTPFAPHRLVFNNHFNTDLPFDEVPRLVVNYRDDEFYSTAGAIARRQTETADDVHLMLKKRPKVLYVADQEHLDVLGDDKNDTGYEFKTLEKYRAEIGERNFAIETDFDTPLSPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV41</accession>
    <name>K1VV41_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV41"/>
    <dbReference type="STRING" id="1220162.K1VV41"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_35_0_1"/>
    <dbReference type="InParanoid" id="K1VV41"/>
    <dbReference type="OMA" id="MYVMDYG"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="57"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="36127" checksum="1582EFE4CCB40D70" modified="2012-11-28" version="1">METSIRSGVYKSSSGRASTPQQTASDTSAMLTTTFHNQTLSNGVNVHYAESGHQDAPILLLLHGFPSTNLQFRNLIPLLAASYHIIAPDLPGFGHTVLPQGTVPSFDLMAETISQLVDALGICKFAVYVFDYGAPTLFRLALKRPELIAGIVTQNGNAYDEGLGADFWGGLQKWWAEGDEYGPMREVLFGAVGDIEWTKAQYYDGVPEENVKLVDPQMYTLDYLQHLADPAKRDTQMRIFWDYQNNVKLYPRFQEYLRTHQPPVLAVWGENDPCFVYPGALAYKRDVPKAEIELLPGGHFLLETHVREVAGLMRQFLGRLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVN4</accession>
    <name>K1VVN4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVN4"/>
    <dbReference type="HOGENOM" id="CLU_1062408_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVN4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29455" checksum="2F5FC2EA47C4CD97" modified="2012-11-28" version="1">MATTPEPFICGNQLGDWVEAALQFYLYTTWVYSIIYMVGYFMNVKIFGAGRIFSSACPKGFSVQNTWAAGYSGDTSCISDVAWSIEKGPRLTYLLMSGCVAALAIVLVSRARDAGLAFRWPSSRRLGARSPPPADQDNKPQHMFLSTNDNNAFQVYQYMLFAFLQIIGLLWRVLTAPTLHDPYPSCPKGLWTHDFSAKNINCFSPFYLAFWVSFEVAQSLLVIVLAWLAGTLLRQDNYRRSVWSPPPPRPPVARPDISLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVN8</accession>
    <name>K1VVN8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVN8"/>
    <dbReference type="STRING" id="1220162.K1VVN8"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1086614_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVN8"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="161"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="238" mass="25920" checksum="F4AC3789598AE3BA" modified="2012-11-28" version="1">MPVTPPPPSPEVIEVPDSSPEEPAAKRRRAILAALSGDDTKKRKSDDADTKPETKPGTSTSSKRRMKGSMTRSRETERMLNSLGKQTNPITHSEAFARTRHVHSCSTGHQQRGGDRGFYTQARAVGLAEAARQNGGREMTYWDVRTKNVEDAARTKLTAAGCVIAINGPTGPRASNLQVQNMITANGGRYVPHQTSRCTHVVAERLSGTKSQKYINGQGSRGAAQRTRAVKVDWEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVP0</accession>
    <name>K1VVP0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_04771</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVP0"/>
    <dbReference type="FunCoup" id="K1VVP0">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVP0"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVP0"/>
    <dbReference type="OMA" id="RTQRWKS"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="34"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD00898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="426" mass="44054" checksum="CDADC3BE6C40BBFA" modified="2012-11-28" version="1">MTTKPTTPIYPCPLSGLSYERSTSPVLSIPDELKPALSAAAAHLRAGRTVAFPTETVYGLGAHSLDPDAVKRVYAIKRRPADNPLIIHVGGMDMLRRLVPASYELSELYAALTDTFWPGPLTLLFPSTNPPPPPAPQTNAIRMPAHPLALALIQTADLPVSAPSANSSGRPSPTQAQHVKNDLDGSEGLGCILDGGACGVGVESTVVDGLAWRKGGGGSVNVLRPGGLGVEDVARVVRAVDEKYGGSTQILLHGRPWVPNANATEPAPKPKDDAPPSTPGMKYRHYSPRIPVFLLLPSNVFPTRPRISPSDSSAASVVAAIRAKNPRLGFLGFEGSPLSKALEGDAVAVRHSLGKDAASAAQNLFGGMLALEQEGVDAILIEGCSDDGLGLAVMERAGKAVGGGGVSGALGQGEGASASGRLWVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVV7</accession>
    <name>K1VVV7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dicarboxylic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000192">
        <property type="protein sequence ID" value="EKD04686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVV7"/>
    <dbReference type="STRING" id="1220162.K1VVV7"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012613_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVV7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="93"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="275" mass="29703" checksum="8EA02D8259099DFA" modified="2012-11-28" version="1">MAPAQSKQPYPFCFLASSRLNVLNYVLVPMPMSPVIRNPGVAASSESPTDGSADRSGRVLHAPARRDESTAQHKQTLANAVKDVVSHKGTRKLNMLELTGIAASSGALGGLAGNPADIVLVRMVSDPTKAPEKQVHYRNALHGVYKMVQVEGFGSLFRGLMPNTLTPGPWRAHELGPARVLRHVQVDAVGLRHVGRSATARPRLLPQWHDCDDNLLAGGRDQVARHALDRPARTDARPDRVDAEGGSRIPVQGLDAELDPPHAQHDLHLRLPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX18</accession>
    <name>K1VX18_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX18"/>
    <dbReference type="STRING" id="1220162.K1VX18"/>
    <dbReference type="eggNOG" id="ENOG502QWA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_6_1_1"/>
    <dbReference type="InParanoid" id="K1VX18"/>
    <dbReference type="OMA" id="APWCMPG"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="54"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="555" mass="59009" checksum="84A094BC9FBDE6E4" modified="2012-11-28" version="1">MTISSPADTVVRNCVVRTMDASQPEADSLAIADGKIVYVGPSSGLNSYVGPATRTVDLGGKTVLPGLMDVHNHHAIAGQHEAELQFPAESSVSEICTAVTAWIRQHPEDKWVLGSKVGSQLLGELQQGDALRQLDAASGDVKVLLTTDCHHNKWANSAALAAGGIDASTPNPDDGEIVRDASGQPTGLLYEGGARSIIRALEKDTDPSAALEAAKKASAAGIRTMHQMGITGFLDAACGASTLRGLKALDDAGALKIHACSSMLINDRIFGNDQLGTALFALQDDVRGTHHRPDFAKIFLDGVPMSYTGAFLEPYTQPTGGEGHCCVRGHTTMPYEELEGWLLRCAERGINVKIHCTGDAAVRFVLDAVERVRAAGHRDAIFHVAHGQFVHPADIGRFAPLGVVADISPPLWFPGAITDAMAAVRSPEEMRRFHPNAELLAAGATLAAGSDWPVMPDPNPWTGIASLVTRKDPSGERTDALNEDQSIDLEQAVRAYSINVARALGLDKVTGSLERGKSADFVVLDRDPFSVPIGKVAGTQTEQTWFAGERVYARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX24</accession>
    <name>K1VX24_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX24"/>
    <dbReference type="STRING" id="1220162.K1VX24"/>
    <dbReference type="eggNOG" id="KOG4122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797806_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX24"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="144" mass="15589" checksum="314EFE940447E0ED" modified="2012-11-28" version="1">MFGFVRLLAGSSRQCSTHARAMPRMAAVAARLPLARPMAPPIAAPQALKAVGQIRGMKVRSSVKKFCDGCSVVRRGHIEYYLHCIPCAPTMACDVLKVYAQELLGGLHLVTLATHTSLTAADFGSKGRIYIVCSKNPKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX30</accession>
    <name>K1VX30_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly(A)+ rna export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX30"/>
    <dbReference type="STRING" id="1220162.K1VX30"/>
    <dbReference type="eggNOG" id="KOG1036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX30"/>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="339" mass="37177" checksum="30FBA8DE41BAE15E" modified="2012-11-28" version="1">MRQLRSFWTAANPSRHLAPAALGWNLVTSLVSGLEPAARGQLGLSNPSLSHPRPVLCVTFGSSSNVAYSGGLDRRIREWNLETGECRVLGKHDDAVSSLAWIPEHNLLVSGSWDRTLKIWDPSAEEPLRSTSSMPERIYNIVYTPATAKVLVSMAHRHVSVYGTYELANAAKEGREAKPDHTRESALKMLTRAVAPMADGKGWASASIEGRIAVEYFDPDPSAQAMKYAFRAHRATVNGQEQVYPINALAYHPIHNTFASGGSDGVLSVWDHSAKKRMRLYPSYPTAISALAFSPDGTKLAIGVSYEHDNAVSSPEDQTRVLLLLKETIMDECKPKARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXF0</accession>
    <name>K1VXF0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXF0"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307951_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXF0"/>
    <dbReference type="OMA" id="MPKGCDS"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="803"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="889" mass="91973" checksum="8535C756BE711A3A" modified="2012-11-28" version="1">MADAAVPAASTTEGDGSGQTTATQTSSKDSKATPPPAQFRPSPVRSFTVSNPYLSSAVKRGSSQPPDERLPISSPASGRGSPGQTNGTTANDFGVIGGSRMSGNGRMGGPLPYGSGPVRASSFSVADKIDQRPSSLVRTLSSHVEELQISRSSSPSQFPTFSPSSSPSTSPTTGNQALPPHSSRGGQYSPPVAPANVSRSRSQSFATGVRPDRSYMMPLSTFDSAGGSSFFEEGWRQDGSSNMSPFTSGMRPFLDNNEEPPKQSKTATRSKTTNFGPKSFRTPQDATFGSRTNWTTSPTTAALTTSVTNALGGVGGQPTYSSVVGGFEDTANGGRSGNSSRRHSMSVIAAPRRGFSFNDAGPGLSAVGGGRSRGLGSLGFTDEELIADSFGNALNLDVDENNQGVITAEPEQAASSLPIFAPGLSDNPRQIARSNPSSDPFFGSSPGGTTGPEQREGGRGRFGFADTRSRTSFSGAVTGSPDRIREGGPGAIGAPVRSGGQPQGPGGFDARFGGGGNMGIPSPTAGGFRPGPFSQGPPPGPGPTFGRPPGGFGYFGGIGQTPGRPSFPQNNFSGFGGSGFGGPPGGPVGGMSNPGPGFPLGSSGPPGPGPNYFGGPPQPQSGNPQSSPSFSSLSLADLGKGIPLASLPPTTPLYIVTFKAGRRDVFYCPDPTLLISNGDRVIVEADRGSDLGTVVYDQLTPVEVREWQERQATAALLSGASQHQPPGMAMANQPPAASGTTSNHKRNGSQGQHFVPAPGAIDFTGADLNTLLSGVGPSGSQMDMGGSGGIGARGPLAKEIMPKRIFTKSSGGAEEQARMVEKLRDEHDAMLICREKVAQRGLPMQIVDAEYQWDRRKLTFFFKADKRVDFRELTKENFRIFKDDPRPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYD9</accession>
    <name>K1VYD9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYD9"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_3_1_1"/>
    <dbReference type="InParanoid" id="K1VYD9"/>
    <dbReference type="OMA" id="RIRIVCL"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="287" mass="31759" checksum="30B7059AE2EED69E" modified="2012-11-28" version="1">MPPEGIRIVCISDTHNATPPVEEGDILLHAGDLSNGGTLRELQNQLDWIASLPHKHKVVVGGNHDMLLDPDFVAARGLRFTPGGTADELNWHDIHYLCNESLELDLPQGKVRIFGSPNTPAPRGIKGAFQHDPELDLWTNRVPDGTDLLLVHGPPRGYLDQGGKGCPHLLREIQRVKPKIVVFGHIHQGRGTRAVSLSERPREPAPLRAASAQRRDSQASLMGGLRRRLSHVFSSHPAPSPPQPTKEPTEPEQEEEKVTMVNAAVHWFPDPYEAARQETKEGYVVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYJ3</accession>
    <name>K1VYJ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000043">
        <property type="protein sequence ID" value="EKD05656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYJ3"/>
    <dbReference type="HOGENOM" id="CLU_1284084_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYJ3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="215" mass="23535" checksum="D329D10EA19405D0" modified="2012-11-28" version="1">MFHKHFTAQHAALSDSITALSNNPILADAPPAAPAWLVQVLNPITNSLNALQHAVYVSEVKAELRCQWQSSAGRADDPACHPPEPFFASMGLFWVCQGLEASWLVKPEQTQKQYMADTNWIGFISIPARVTSVLLQLFTNARAMSFAGAYALEAYMVLASGLFNILYNSTRFVGAYYARPGYHVFEIVAAVGALGAAFQAATLPRVEQNQPEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYJ6</accession>
    <name>K1VYJ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000219">
        <property type="protein sequence ID" value="EKD04607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYJ6"/>
    <dbReference type="HOGENOM" id="CLU_572651_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYJ6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="477" mass="51187" checksum="EEBA87AA541C7D91" modified="2012-11-28" version="1">MYNTPAQPPKRRVGDTSLSPQSPPESTTHATSPRPVAKRREIPKPKPQAPLASSPTTRSSAAAASSAAAASSAAAVSSSAAVSRAVLGPFSSVTASGSGTMTSTTEMRLTSPVEVRQGTAARRIPLAVIGSTTGGVSKGSGIQAPATAGSWGAGRRGHASNVGTGKSKSGWSSPPTGVSTIIVTSTLPADAQAHFITQPRTTQSKAVAGAKGKARKELFNLFNNLVGGKKTEAANGFCRLTRHGDVLRRVAKRLELGEGSLDYIFLPIPLSVLSDPRWKKSATVTLKIDDPTVTDVELSEFDVGDLRVTMFAETGEKILTYGAKNLLTKRAKRCWAEATMTMQILCEEFAVRTPSHRVDTPDSGLPTAAEDAWSPPVEPEQEHDGHTLQPVPTVHNRPTDPPEQSHEALVRRLQEAEEEIRRLQGVADDQQQRIDTLEGESKLRDQRLHRLQQWIESTLGVEFQDPLADHEDRPHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ21</accession>
    <name>K1VZ21_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ21"/>
    <dbReference type="FunCoup" id="K1VZ21">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZ21"/>
    <dbReference type="eggNOG" id="KOG3366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2122795_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ21"/>
    <dbReference type="OMA" id="INWAGIT"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="114" mass="12522" checksum="ADF1499612A69B40" modified="2012-11-28" version="1">MPQVDLSHYKSILKNASAVEAAEKALSSFKPVDYDVSKWDKVVDAFEQKAVSQAKETVQKVDKEETDLKATLSNITEARPFEDLTSDEAAAANPEISKATEAMLKHGRWTVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZJ5</accession>
    <name>K1VZJ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZJ5"/>
    <dbReference type="FunCoup" id="K1VZJ5">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZJ5"/>
    <dbReference type="eggNOG" id="KOG1172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002289_7_2_1"/>
    <dbReference type="InParanoid" id="K1VZJ5"/>
    <dbReference type="OMA" id="RRAPFYW"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="217"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="403"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="559" mass="62004" checksum="993AE9B2C4833A96" modified="2012-11-28" version="1">MGRRLSSSSSRLKRVESPADAYSPPIRAERPSNPPEPPLTLLHTTVSRASRRAEAAEEAPEITREKSRTSVHAPKTYNVWIPFSGIMHDIRARLPWYWSDWKDAWNYRVIPATWEATGQYGVQEVLLASFMAAFVASVFGGQPLLISGVTAGLNMVKLIKYFTRMFCDTFGFCELFCRMSKLTADVGAVYVQYGIQVVTRQFHQSSPGSAILGILFVLEKNMTLPTTAHSFQPAGDRSWLVRFWQLPGKYVGIAFPFGIVLFILFYFDANVSSLIAQDSEYPLRKPAAFHWDTFLLGITTFIAGLLGVPAPNGLIPQAPLHTASLVVMGYEDGEHAPLQRRDSGEDVAARDFSDAEEGRAAPLKTVKSRASSVGLTRRVTQLSDRAQEARRRRAAEAERRKEEREIPVAVVEQRVSNLAQGCLCLVLMTKPFEHVLGLIPKGVMAGLFWYMGTDALLNSGVTAKMLYLVRDPRAISPSDPLNHVRKSRIILFTLIQLIGFGATFAITQTIAAIGFPVVIILMVPVRFFIVPHLGFTKEELEILDGPVASPFVSCRATGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZQ5</accession>
    <name>K1VZQ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZQ5"/>
    <dbReference type="HOGENOM" id="CLU_1644908_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZQ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="161" mass="16793" checksum="DFBF10C4F46F0D2E" modified="2012-11-28" version="1">MRLEQSPKTTPQGRAATACLKRADASYSQANGHVSAISVRLGPGFFYPRAPDRLQPPPAARATLSSLGVFVHEECRATAVVVSTVVEIRCALLMLALAISAAPTNACVTALQDAQPSVLSWQLSASAEPALVSVQLISLAAQVTAVNIGRNAAHVVHPCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZS4</accession>
    <name>K1VZS4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21 22">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">A1Q2_00664</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZS4"/>
    <dbReference type="FunCoup" id="K1VZS4">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZS4"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_1_0_1"/>
    <dbReference type="InParanoid" id="K1VZS4"/>
    <dbReference type="OMA" id="MVDIATQ"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0010">Activator</keyword>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="18" id="KW-0779">Telomere</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="11"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EKD05057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="33340" checksum="78B432D65EA7F444" modified="2012-11-28" version="1">MSYTPPGLALIESSTLLKQGAEGRVYINDSLFGTPSVYWPEPGPPAPSTASSSTPAKPNECASLPVIIKHRFPKRYRHPALDASLTKARLQAEARALWRCAKLGLRVPGVYFVDESCGCLGLEKVPGWSVRELLGGGAEGELEVEQVDEVELPAEVARLSVAKGESGESAVATAEEVEESEGLRALKAQGKTVEDLMRSIGSALGKLHAASITHGDLTTSNMMLSPTSSGEKELALVLIDFGLSAQATMPEHYAVDLYVLERAFASTHPGSKALFDLVLESYAAAIPKKWPGIESKLKEVRLRGRKRDMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W120</accession>
    <name>K1W120_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W120"/>
    <dbReference type="FunCoup" id="K1W120">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W120"/>
    <dbReference type="eggNOG" id="KOG3009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_3_2_1"/>
    <dbReference type="InParanoid" id="K1W120"/>
    <dbReference type="OMA" id="FNCIIAT"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="7">
        <location>
            <begin position="335"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="682" mass="71515" checksum="9C1193770A4F4B8A" modified="2012-11-28" version="1">MPYPANAETAASLETIIRGHGVVPATIALMDGKVQVGLSDAQLEELANAPRTESCKVSRRDLGAALCLKRYGGTTVAGTMILANSVGIQHFVTGGIGGVHRGAEKSMDVSADLVELGRTPMSVVCAGAKSILDIPRTLEYLETQGVCVAALSEKSGDFPAFYSPSSGEVAPWHFKDICEAAQVVQTNLTLPSPQATLVGVPIPQEYAQRGEEVQRAVEQAVRESVEQGIDKRGKEVTPWLLKRVGELTGGTALELNIALIQNNAHVGAQLVREIWAQREQDFQKAQNASSSAYFPSPGAQPASSSPKRQLESLAQIPDLPDSPDSQQAPVLPDPSVVVFGSAAVDITASTALDHPGSTSPGSVQLTAGGVGRNLARAAQALLPDNAVQLVSPVGTDGLAAVLKSEMADGALRTDGLLPREGRTASCVLFLSAGELSHGVADMSIVETLSASDIAASLPSTAELVVFDLNLSSSSVAALLQTCAERNLRTFCDPTSVAKTPRLLPGLLNGGLTHFAPNLAELDALHSALEPALDDTPAGEAAWEAVNALNLGAEFRAAVESRFRSVDWVGQTGAIRKVVGLTPFMDNVWLKAGAGGVLSLRFQDKRDAKGVSQRIEHGKHKGQWLNIRHYPAPVVEGVLNTTGAGDTLAGSLISSLSTKEEEGMVDRALQRVKATLESHHSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6D8</accession>
    <name>K1W6D8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W6D8">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6D8"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000691_1_1_1"/>
    <dbReference type="InParanoid" id="K1W6D8"/>
    <dbReference type="OMA" id="EVMCAYI"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="854"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1234"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="798"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="817"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1256"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1946" mass="216053" checksum="4B048E34AE3D3FD1" modified="2012-11-28" version="1">MAEQNIDSTPPPQEDTSVDAVSASEPPTDHADNKILPIEPEAETETDDLAETEEIPLDDPPPPPPPKNDSSEAELEHDAEPAAQSELPVSESVSAPVADDVPPPPPLIVSEPDDGLHSVALTPVQEQEPTNGETEGEEAKGDVLAQSETVDTPAEPSTPTVPSAQSPSEVPSPSPVPRTSSTPRMSAPGSRPPSAMLRTAQHHSRRSSTSTTISLTQHPGGHAPQLSSILITPPLKVLVNSKEARKSASFKAAAERALQLCEGGADGGNAAFMHPREIFEPLRLAISNPQTTSVPILVTSLDLLAKLISHSFFSEPNGPPPGMSPLPDLITHTITLAYTENTPPQVALQVVKALMAIVLSTDPGMLVHQSSLLKAVRTVYNVFLLSNDTNNQVIAQGGLTQMVHHIFSRVQRPEDKRKTMNGGQTPQPDSAPGTPSPNDMADAEERAGDNAEGQAQDNALTLESFSQPNPNDEVTVAPARLGDDLRSRDGTQAQLPSQTISIQVPNGDALDIPEGDGDVPNEGTDDQGRPIPTQELFVKDAFLVFRALCKLSMKSLVTEAELDLRSHAMRSKLLSLHLVLTILRSHADMFYDPSITIPSNTSAEQTPFLQATKQYLCVRTVDRDLLVHPEVDARPSQGKLVGTANRADLQKEIEVLMNEIFIPILEMRHSTIRQKSLILGVFIRLCQDPQALVEIYLNYDCDRSAPENIYEKLMNIVSKIGQTHFAPPTKEELQAGSSKHASGSHGPSIPPSLSTSALAQESPQYAGLSPEIKLRRQSLECLVAALKSLVAWSSTPKQHGDENLARQSVDDDRRNSTSELSTTPTRDGSRRSMSGYPSQSVTPDIPIGDDDVNKLESEKMRKTMLQDGIKKFNFRPKRGIEFLVQNGFIPSHSSHDIAHFLLANDGLSKAVIGEYLGEGEEENIATMHAFVDMQDFASSRFTDALRAYLQTFRLPGEAQKIDRFMLKFAERYLHQNPDTVFANADAAYILAFSVIMLNTDQHNKNLKTKRMTKEDFVKNNRGINNGEDLPEELLGEIYEEIQTNEIKMKDEAEAAISGPAGLATVGRDLQREAFLAQSENMANKTEAMLKSMARSQRRGRIGADHFYSASRIEHVRFMFEVAWMPFLAGLSAQLQETEDMEVVEQCLEGLRSAIRIGCVFDMELERNAFVGTLAKFTFLNNIIEMKPKNMEAIKTLLDIAVTDGNNLKGSWKDVLTCVSQLERMQLISSGMDVPDLNRRASTASKKSTNSKKDKKRPAEELAEESRSSQVTVAADKVFSLSQNLSGSAIVDFVRALSEVSWEEIQASSLTPRPRMFSLQKLVEISYYNMGRIRLEWSNIWNILGEHFNQVCCHNNPNVSFFALDALRQLAMNFLQKEELTHFQFQKDFLRPFEYTMVHNVNTDAREMVLQCLQQMLQARVQNLRSGWRTMFSVFSAASRVMTERVANYAFELVTLVYREHFALVARYGAFADLAACLTDFCKVTKFQKISLQAIEMLKGLVPKIVEIPDVIPVAGSELTNGKAKSQNPQDDPMLRYWLPVLNAFYDIIMTGEDLENFSIEFWNTICQQTLFPIFGVLSNSNLVKFKSAEDMSVWLSTTLISALRDLIDLYTYYFETLQVYLDGVLDILIACICQENDTLARIGASCFQQLLESNVTKLSAENWEIIVTAFVQLFRTTTAYHLFDPSLSTDRKPPADYVDDDQPFNKFVAPAPLEPVQNDPPALGEITYGEQRRIFKTIIVKCVLQLLLIETTHELLQNEGVYNTIPAEHLLRFMGVLDDSWRFARKFNANKDLRVKLWKVGFMKQLPNLLKQESSSAATLITALLRMYRDPREAHISVRGGVLDRLVPLGQEVTRDFIAIDAASQPRNIAAWSPVVSDIVRGVADFDDNAFDEHVHTFYPLVADLLLRDVQPEMRLAVRDFFLRAGQRRGIVPQEEAVPEPAVAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7P8</accession>
    <name>K1W7P8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7P8"/>
    <dbReference type="HOGENOM" id="CLU_470247_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7P8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="580" mass="64516" checksum="7EBD5D67AA388BFE" modified="2012-11-28" version="1">MPTVASPSLRPTFVKVFAEVATHDVLLCWKHRLNDSYDVTQLCDLVIGGLQPGAEDIFVAAAVSMEDCVLLVGRAGRQHHSADDWLRRFSHDHCWVPREASPARGATSLSSEMEGTTWTLAGMIDLKMDTELRHLEGEDGSWLADRKQDVKKLLAIKFTGDMKPHRDLMILWTAWQPLPPAPSGSPKVKGLFVPVFAEVRKHDIIAYWYDLLGDSRQVSEYCEVVADGLESGAEEIFLEAAEGRRLCPSFDRMKGSLMRAFLFPTWIVYFLLAEPVDDPRLPTLGYVGSGTACAGQYTGGESRARGHLGNFRNGRRVAIPGQWHELTSSTQLFLYRAADGNVYKISVLVLWSSRFDFRTAADEEIKRRRRDVHVVESALATAMGVHSVKGSRTTVFDLPPATARFKPCNEADPLSAMQTMGYIQYQVAGLQRTLSIRDLTMSLLRRSGGQMELGTAELLHYMRCVVPALATRLTTCVPRRLIPGTTIRKDGSGRQIIRLSHPGAVDPEVYNAVSAIIPAPATSSSIDQDVKFFRLLVVEALELALFPDLLARAIRASIRRRDELRDSNLHSILFSDALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7X0</accession>
    <name>K1W7X0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7X0"/>
    <dbReference type="STRING" id="1220162.K1W7X0"/>
    <dbReference type="eggNOG" id="ENOG502SE0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1157097_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7X0"/>
    <dbReference type="OMA" id="GLYKVMG"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="59"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="274" mass="29879" checksum="D203E681FB6D9921" modified="2012-11-28" version="1">MSVLRPAARQLRREGKLTRWSQLTPVRNYATPSASTTPDAASSYLSELLELPSSAAFPPQLALQLLTHKSYRFVNRLTNMSEEELVQSQVSHNARFSFLGRRALASYLAMFLHSQVRTAEGARKTDFLNGKDIETRLADMLHENNVGRWVGDKWGVQNVMRWTANQVGVVRGRTACLETESAAIAQQTLPIMPRGRWKSANALASKDAAVKGQAVAAIMGGVFQHLGSPAAQRVFHIHVLPHLAPQLKDPALIEAAQKLAASAGKVGVVAKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8F3</accession>
    <name>K1W8F3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8F3"/>
    <dbReference type="HOGENOM" id="CLU_1310881_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8F3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852766" evidence="1">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="210" mass="22397" checksum="B68929D3365EFB3C" modified="2012-11-28" version="1">MKISIAISAVIALLVGHSQAAPALMPNSAPVLADSAFEARDIDMVARDDADDDDFELDPETSALLDRLDSIPADVLDAGEDATASWLSSNLWVPHTERALSIFETDGTEGTLDLDARADKPFNAPKCLTAMGVALGMNAFPITKVVRIVKIFKKFGDMKKTISRFRAVRTVKGIRDVGGKELVELATIIAGVDAVATKCFPNSLLGQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8M9</accession>
    <name>K1W8M9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC98003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8M9"/>
    <dbReference type="STRING" id="1220162.K1W8M9"/>
    <dbReference type="eggNOG" id="KOG1625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1587661_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8M9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="189" mass="19889" checksum="929D72686EFEED58" modified="2012-11-28" version="1">MTTADDGARADLTRCFKGAVSEHEDVMAESQDLFFKYEAFLMSRPSGLRQKLSKFNLDVARELRKEIQRESQSKASKAASSANNGDTKVAGVRRKNAAVADLGGFLDGLSTPVKKRNVATQLSNTSNNANVPSPSSMSTPHRTPTGPIPTASSYRPSGPSRLAVPVSTPLGKDGIAPSSPVSGAESPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9A9</accession>
    <name>K1W9A9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9A9"/>
    <dbReference type="HOGENOM" id="CLU_296863_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9A9"/>
    <dbReference type="OrthoDB" id="3236348at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1016" mass="109231" checksum="32A87E075CEF12B7" modified="2012-11-28" version="1">MPEASRSQAYALSAFTSANPVAAPSNVNRDDMSIDSSRIVQGQAQVNHPFQFYAGHQRQSASVGDVLGASLHSLETRVGIHSAGAVRANTLKRWTKCTGAVRAHTLKRWIKCVLHIAKDEVIGQASIGTGRNPEAFNGKALDGSDGLKAVLMGNTHPILVGKLKLNRFSRSIELYGPEEMVIVAKQIDEKILAQPSRASTWVQSKAQHQLLLSVGGRTCTVAVAGQDGVAAELDEFSHDDDDDDEFSAGAYIREKDGQTLPGQSGMSTELHVPAAQRVKDLQLEAASSLLPLLIKRGTLHTTTADGQVVFFSDLDHFLQSKARSFRGGGDEPLFREFSGDSSFTELPATQSNLKARLDSLALEAGLPAPRPYNWRHYVGDAVGVVFGEVAQKAALHHGLKSNTALRNYSRGGRAVPVTRAAHDDPTGMTAADRGRLEKRQEDLRRETTPAISALVHQARHGSALPGEFMPTKEEESALDRDPEVARMVDWSRSKKREAQRKIDAARYDMDMDEFEAARAELDLLRGGLPQLVKIGLGDSSPVTGEKRKLEHALDTPRNPCAASLVLQLLQALWATMTGQTTVKNVENFIRTFGYCPICPLESVGFLAWQRTRDGQSLRPSTFTTGTFVKGRKVYASQHIKEQHPAELQMMLEGWGVVARSGGSLPVLTSEDRKKLRQFTAQALETRPVTGSISLSALAAYKVEYNTFVDSWFSTGPMCKPAAKPLAPYPESGPSSKGKEKETTPILNTDVDQALSAAVRSSNKRNFIDVDNPATSSSSGTGNPAPGPSPAAPPFTSATTPVVGYNGEHSSAHGTFGTPAQQLGAAGMFDPNKLDPYGDLAPPVFMNQLYQCASFVQNERLYVLQYLQELRAQGRSPPTEVLEQRYPWLYDDVRGTQLEPPSWALFRSLHCYLDDERGLLVAAQEGVPVSGGSSSVGTTQPTLDATAGQTASAGGGGGTSAGPRAAPLSSAQQSGEARRSSDSASRNSPAAPTSQQAGAKTSAQASTITAFFKPKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9K7</accession>
    <name>K1W9K7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_07342</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9K7"/>
    <dbReference type="FunCoup" id="K1W9K7">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9K7"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9K7"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="152"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC98328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="464" mass="52673" checksum="D013EC1AA6C1AABA" modified="2012-11-28" version="1">MIDLAYFQTDKGGNPEIVRESQRKRGAKVELVDEVLELYNQARAAQYEVETERRAVNAVQKEIGAIKKAKGDASELLAKKAEHDKKIAELQAKANELNNARDRTAARIGNIVDPACHVSLTEDDNPVKAFWHPEPNHKGNSAPLTVEDKQTDILPHHEVMYRLEAFDGERGSKINGHRGYFLTNDGVDLNQALINYGLDFLRKKQYKKIQAPFMMRKEIMAKTAQLEEFDEALYKVTGGDGVEENDRYLIATSEQPLSGMHSDENIEPKSLPIKYAGYSTCFRKEAGSHGRDTWGIFRVHQFEKVEQFIICDPEESPAMLDSMVETAREFYESLEIPYRVVNIVSGGLNNAASIKYDLEAWFPFQGEYKELVSCSNCTDYQSRSLNVRLGYKRAANEKAGFVHMLNGTLCATERALCCLVENYQTPDGIRIPKALQPYMQGREFLPFTQELPKKDAKKEKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9M4</accession>
    <name>K1W9M4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9M4"/>
    <dbReference type="FunCoup" id="K1W9M4">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9M4"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022571_2_1_1"/>
    <dbReference type="InParanoid" id="K1W9M4"/>
    <dbReference type="OMA" id="VQVYDHH"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="594" mass="66223" checksum="E8922A24527FFD0B" modified="2012-11-28" version="1">MLLAQYDSSDDEAGPSNAPVQKVEDTDETDEQIEQQVQTDAFGIATSGPSKVAKVDTKVSVAAAPDVLKEDPNDMANALITRSTDKVINVNISYDDMTRPVQGPVDPFNARKNEGMNAMNGHVEEQAMDSYEFERQKRTFDVHGYALDPTANGGGGWIGATDAAAANGFGMIDNVRATNRQRKEMKRKRKAKGDASIVDGEGSYLGPWADYEGDKAGEEPEVEEETDEWRAEKKRREDLKAAAQERNKAAREEKSIFHGKELTDYAGRTYMHIPTDVDVRLNPPDDAPAPNAYVPERCIHTWHGHNKGVTAIRLFPKSGHLLLSGSMDTKIKLWDVYHEGNVLRTFMGHSQAVKDVNYNNKGTRFISSSFDRTIKVWDTETGQCVQAFSNGKIANVVKFQPDPDKQNIFLAGMQDKKIIQYDLRSHEIVQTYDQHLGPVNTITFIDNNRRFLTTSDDKTIRGWDYDIPVVIKYIAEPYMHSMPAAAKHPNGKYVAFQSLDNQIQIYDTMNGIRQHKKKHFSGHTTAGYACGISFSPDGKYISSGTGGGDVVFWDWKTGRIVKRLNAHKQVVIDHCWLPNEHVSGAGASPKLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA03</accession>
    <name>K1WA03_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07185</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="AMBO01000388">
        <property type="protein sequence ID" value="EKC98503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA03"/>
    <dbReference type="FunCoup" id="K1WA03">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WA03"/>
    <dbReference type="eggNOG" id="KOG0262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_2_1_1"/>
    <dbReference type="InParanoid" id="K1WA03"/>
    <dbReference type="OMA" id="YSPESMC"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="381"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="250"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118198" checksum="71883D0562B94D73" modified="2012-11-28" version="1">MDIAHPLTSEVTSLSFSFLSSDDIRSISVKKIDNPVLLDNLNLATNGGLYDPKLGPMTARDMCETCGQSYFACPGHYGHIELPSPVFHPLFMNQCYNLLRATCLYCHHFKMPELILRRYIARLRLLDAGCLEEAHTVANFHPVTKDAPKDGDTQEDMDAGVAGETAAEFIQRMDEYVRQVLKHRKRKHERDNYKDGLVFEERKRVLNEFGKKLWAKCSHCQAYGNTFRKEKTIKIIEYDLSPKQKLANSTMGLKKPHASFSSRSIKKPQKGKEEEDEGIEASSASSGSEAEDEGMDVDEVEAEEEESEEEDEGLTAGPARTASGQVKGARGRNERVMAAAEVRSHLRRLFQKEAEACSLLYGRHGGPQAKSGHIPPPPIADMFFMDVVPVPPTRFRPPAKMGDDLFENSQNTLLTAIINTCERIYTVNQTLRDFERQDKSEAVMEALKNLDKTRSFEILLESLIRLQHDVNSFMDSTKNPAVMKQGKLPPQGVKQLLEKKEGLFRKHMMGKRVNYAARSVISPDINIETNEIGIPPVFAKKLTYPEPVTPQNVHEMRQLVINGPKVHPGAALVQNEDGSQISLDRTTLEQRTAIANQLLTPQNDAWAGSSGGPAARNKKVYRHIRDGDIVILNRQPTLHKPSMMCHRVKVLHGEKTIRMHYANCNSYNADFDGDEMNIHFPQNETARAEAQMIANTDNQYLVPTSGNPLRGLIQDHVVAGVWMCNKSSFFTRDEYYQLIYGALRTENNYSGGGRIITLPPAIIKPRPMWTGKQIMSTILVNLTPANAKGLNLTSKNKVQNKLWQRDDSKDENMSEENVIFLDGHLILGVLDKSQYGASAYGLVHSVHELYGPYIANRLLAVLSRLLTKYLQHTGFSCRMDDLILSEEGERLRKQILDDANEDGMRTALQFVGLPHDGDIHNPELQQNLKIRLEEILRDDNLMAGLDAKMQMAFNKTTSKINNDVLPAHLVRPFPDNNMQMMTISGAKGSKVNASQISTLLGQQALEGRRVPTMVSGKTLPAFKAFDTQARAGGYVANRFLTGIRPQEYYFHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBR3</accession>
    <name>K1WBR3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBR3"/>
    <dbReference type="STRING" id="1220162.K1WBR3"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653847_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBR3"/>
    <dbReference type="OMA" id="WTSEMEE"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="423" mass="45393" checksum="3799A815FFF71DAD" modified="2012-11-28" version="1">MSTTITSTSPIEASHTSGPIALAGAPRPAGSTAKSKPRKRVNTAEKRHQHNAIERQRRETLNSKFLVLARLLPSLAACRRPSKSAIVNGSITHLTHQRNQRLLAAKLLRQLTAERDELFAEVNEWRKANGFPPKAGAAASWTSEMEEICQVEKETFGSFANVDESNEEQNEDEEEQPAARPSSAGSGSMNVETAAVVAGNINTGLFTPRNSTDINATSAPLTVNTNMNNVNWNNGYQVSPAVPFSAFMSDSATSVDSSESPLGSSHPNAMPTPPSMEQAMYVHQTPSPRSTASADDAQPPVQRPAAASRTASMPAQWGQQHLAAFQQSIQQQQQQAQAQAQQPQQHYAVGAALPGQQQHFAQYPGQPPMHPTPANAQGFNQLMASMFSGHPGDAVQSMKPAVDQNAMFNFNLAGWGAEQSVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCG1</accession>
    <name>K1WCG1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCG1"/>
    <dbReference type="STRING" id="1220162.K1WCG1"/>
    <dbReference type="HOGENOM" id="CLU_821803_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCG1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="319" mass="34916" checksum="6A25EBCECA5B381F" modified="2012-11-28" version="1">MPLIPRDFGPMTEEQIAARMRPIKEFALGCIMSMIIIDTFLCAVFLMQSHRYWMVHSSDRWWIKMIVIAITFLGLFTTGPGSLSLTCLILIGFGASAGTKATFGRMQSSRDAHKTKVNHHAPHAPHARESAASPHPGRDVHGRVPDRPGQSVLQHAHGDPEQALHRGAVLLAECARHIRNPQRHHGLYGQCELAPSSKADKQHYPEQQSKAGPATVHVDVETETYETRVELPRPGLNRMQSAMGRQQHHALEKIEHSDEDEGESDTAVLRSDCGSNVKLTPPTPSDGSPPNTPGALAPHGYRTAPAQSEYNDDKGAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCQ4</accession>
    <name>K1WCQ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCQ4"/>
    <dbReference type="STRING" id="1220162.K1WCQ4"/>
    <dbReference type="eggNOG" id="KOG1882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022457_1_1_1"/>
    <dbReference type="InParanoid" id="K1WCQ4"/>
    <dbReference type="OMA" id="HEECKGE"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="139"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="26298" checksum="D22D7A93723D2602" modified="2012-11-28" version="1">MPRSPRDRSPRGYGRSRSPPPRSRDDRDRRDRRDRDRSRSPKREPGWGDEYTAKDRERERERDRKRYDEDVAGDKEKSPPKPNMKNTGLLAKESNMVKGVALKYHEPPEARKPVVNWRLYVFKGSEQVDLIHIYRQSCYLLGRDAVVTDILIEHPSCSKQHAVIQFRQITKTDKYGETTQSVKPFVIDLDSTNGTWVNGEEIPQSRYYELRSGDIRDVEPGVCAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDU8</accession>
    <name>K1WDU8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDU8"/>
    <dbReference type="HOGENOM" id="CLU_2387724_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDU8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852815" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10840" checksum="CA7FDAD2617B1227" modified="2012-11-28" version="1">MILHMLSMQSVGFALGATLAQNATRDEWRDESKLRRVYQFCPSHKKTDRAYPDPEWLRNGRIRISARLHHSSELPLRVPEIGEVSEPNIVLCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE93</accession>
    <name>K1WE93_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE93"/>
    <dbReference type="STRING" id="1220162.K1WE93"/>
    <dbReference type="eggNOG" id="ENOG502S3F0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059975_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE93"/>
    <dbReference type="OMA" id="HYARTSM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="66"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="3">
        <location>
            <begin position="296"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40992" checksum="4FE77B9098AB04C2" modified="2012-11-28" version="1">MPLPKCPPGFTDHIFKRVHGLPLPLRYWPPRASSTSTSPSPDVPSRVTNGTAQPNGASPARDTPWLLWVHGGGYTCGKWAHPTPWLLPAFSEYGLVSVGYRLQPEASLAEMAQDVVDAYHYARTSMGLGDRCVIGGASAGTTVAALAALELIRRERKATGEGVGAPRAFLSVYGLLDSLAYLEQERNQGPQPEPSYLVSTDEQLAEIYADPDPAQASVQNPWDTELPPHVPLQEIRDHLGLPGYEPSDTELRRVDVYSYAACHGNLFESVCRMKDYHSDSEFKDRVRADSPQHILQKEGEFMPTFLMHGLADDIVPASHSENFARTLRSKGVPTEEVYVEGAGHVYDFGFEKAGDAGWDVSVVPALRFLDRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEF7</accession>
    <name>K1WEF7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEF7"/>
    <dbReference type="STRING" id="1220162.K1WEF7"/>
    <dbReference type="eggNOG" id="ENOG502TFY7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305695_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEF7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721:SF1">
        <property type="entry name" value="OS04G0446401 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1122" mass="122543" checksum="E54D650562B7CB81" modified="2012-11-28" version="1">MSHLPPTRNTIRAPDFPWASIGGRWMLGLCDAVLTTDELVAWLIGIVPCLRCESVEDYLRKLVRRSAGELLQAIEDYEQHGRVARPTCECPDRNLRRSNRAPSPPPATCILSEESSWPFDLQSPSEQALHWIKQRLQERRVLEKMKTAWTAYCPQAILSFVPQASFRNSTAADPGCNPQTTFGPCGDYGVVLRLLSEDIGKQKPAETRWHAFLERPGPCVADTTLSGVLDEQRDSEKRPTDAHPGLTLSHVVATMVMDAGFHDEDALAVFGGSRHYTVEVHPFRTSPSGATSMLPHTTQCISQPTTLNDICGVTVLFLGCLALKNEEACDKLLDMRDTGAAILKDLSDGQVDGVLGDRVLARLRRLFSSAMGMETVWTIDALSCRLFTWATFWLRQPSQKQERSLSPDGRFTFDITVCAIFQLWNNSINSCGDRLFTPDTTEGWEDTAEVTGMGVLYGCAVAIACIRCLKDIGRDTDCEHPESDFDTAPSSFALSLFKAAFQVHPSQCSETVLIGQLAALIVEDGTPLSQDIDAQWSTVLSLCYGLQNVRRNLQAISKHYEQQVDGRRLFRAFRQSFSCIIRPYSEVASYRSDHFFHPDQPSSAIKLDKYRFLGDGKVTHYNPAYGKTIFQDLASQRLEWSDQPKSPGHKSRLRDIDLFSSLRRLDLAFRDGMDSKTQDAGSDLKESPPSPMSLSISSDPTAEDRSPTGLRQMLARFRRPSPSNQPRPTRSPPSSPTPETISLISSSDGVSYCAESPSGSDGSDNAPILPYSSLLRTSSGSDISQRERHASLSSHLHAHSADEEEAMEEANSIRSEASGTSFRPSATHYISPELELAEEHVLIKSVSNPTIDSSLEKRRRNLQPKTSMSSSEVELNRDKHHSAAEAGMLTPVAASIRSTPETTEPVLSQKRINAWDSLDAASQYHLMTATPMSDTLSTSAPSPPPSIPPELESPGSPPPPPSASLPPSTQELTITIPTSPDAAWVPLPVSFPPACPKPAASPSSPNSPLPPASPQPPPAPPPAMFPRPSERPLPRPPIALSETSSAPPTYSESVRSTTFSDFSSYQPATGALVLLTVAMLAPSSFSGPLILVVLLFYFAPSRTGVQRLSAAGAPAARPHPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFC5</accession>
    <name>K1WFC5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFC5"/>
    <dbReference type="STRING" id="1220162.K1WFC5"/>
    <dbReference type="HOGENOM" id="CLU_131496_10_2_1"/>
    <dbReference type="InParanoid" id="K1WFC5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="100" mass="11320" checksum="7F87143FDC9AA7AF" modified="2012-11-28" version="1">MPIVLVAKLRATSPEAADKIEQGLKAIRDYATSDKEPGCLLYYPARHNEDPLAFTVFEEYKDQEAIATHMKTEVFQKFASDESVFEGGVKGLDLQYYTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFK3</accession>
    <name>K1WFK3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFK3"/>
    <dbReference type="eggNOG" id="ENOG502RBH6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572652_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFK3"/>
    <dbReference type="OrthoDB" id="2571862at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="477" mass="51683" checksum="5728B2029AC44B30" modified="2012-11-28" version="1">MSLPRVAEPHTPDVSGLSIGLALTPPSVTGKRVREEDWHPAELDILKMILARPPRDDLHYPPGALPPPDVLDELATFIIVTYRHASVAMEDSSEPSPSGLPRSESESDMSDDADASFSTDSGYPLRAEGWPHTWEETRLMLTHLALEDTRWAADRDHTKLSRKERLARRNQLKRTDSRDSLSELSGSESDLERREREKLSRAQRLSNTLQASAREPSAPQAPPPLSRAVSLGGPSSAPQSRPVPTHSQGALGLGGLGLGMPMRRGGSARSMSSTGSQRRPSLLARGRSFTAQDLEDELASQQSAAAAERERLEREREQRESKRDRGRSKRKGSDTEEDEPISPAALPPPLPPSSGQPRLIRSLSEMSRPRASVPLNTRPGSEEPKGSPPMRGPLSFGPALDALGYPRIAPAPAPAMLPERRRSRRPTGPTLAMTAMAGAAALRSPSSNGSPLPSPIIEPNAGPLRSPFEERGGNPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH91</accession>
    <name>K1WH91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box protein, Met30p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH91"/>
    <dbReference type="STRING" id="1220162.K1WH91"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_1_1"/>
    <dbReference type="InParanoid" id="K1WH91"/>
    <dbReference type="OMA" id="GIAHVWS"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000051">
        <property type="entry name" value="F-box and WD-40 domain-containing protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000987">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="309"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="396"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="634"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="674"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="728" mass="80093" checksum="E5C0ED9D30F4789F" modified="2012-11-28" version="1">MSSTDRAAESSAAKSFSADASITKDGRKLCVRHMQMANQNVNAKLQKSLDSLPVPERADITHLWSTFSAAPHHKRKLILEGILTMCCFSQLSHLSDSLNQIIRIDPFSLLPREVSLRILGYLDAISLGRAAQVSKTWKALADDDLLWRRMCGQHIERKCEKCGWGLPLLERRRLKVELKDRSPIVAHGVGGHHDHAHDYGVKEVMTRSEVLGPERASTSSQALVSCDLATPAPNSTLKRPAPTEGSTWAREKKPKLEGGSDSEGESAADAKAGILSRDVRLTRPWKSVYCERLIVERNWRKGRCQTKTLKGHTDGIMCLQYHTALTDPNYPVLITGSYDRTVRIWNLDTGEQVNCLRGHTRAVRALQFDQMLLFTGSMDGTVRMWNWRKGQCLRVLEGHRDGVVSLHYNGYLLASGSADSTIIVRNLRNGTKFTLAGHNEWVNSVVIWDGKSSPGDLDPTAMPTFTQALSRNRLQASPGPDNTAFDIDAGTMLFSGSDDGTVKLWDLVTQQCLRTFTGHKGQIQSLRILMTDQSPEDEDDHEPSATEGGSAFGQASAVGLNTSPYHSRMALPPTGDEHVVPHVYVHSEEDNHHRKAKEASVDRAEVKRPLLVTGSLDGTVKVWDVETGREKSTLFGHIEGVWAVDIDALRLASASHDRTIKVWDREAGNCVQTLVGHRGAVTSLQLSDDMIVSGSDDGDVIVWSFGPGAEKKANSTADNSACIQAIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHK1</accession>
    <name>K1WHK1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHK1"/>
    <dbReference type="HOGENOM" id="CLU_097662_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHK1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854428" evidence="1">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="184" mass="19607" checksum="038E5AC710F0DAA6" modified="2012-11-28" version="1">MVALSLLFLTALPAFAFTSPVERDSNDTSVTVAEAEASALTGASAATESSAVSTAQSNKIQLKGNTLCLETMDSSEVYIKPCGDGAAQKWIWEAAGDKGGVPHFTIKSEVEGVCLSKEPVSGRPDYISTRLRAVLESCGTAYTWGWYGDRLCIRDWYCLGVDASTPRDGSGLRFYGNAQWTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHV2</accession>
    <name>K1WHV2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHV2"/>
    <dbReference type="STRING" id="1220162.K1WHV2"/>
    <dbReference type="eggNOG" id="ENOG502S0PY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586881_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHV2"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="466" mass="52316" checksum="785F8A9544401723" modified="2012-11-28" version="1">MGQTAAQPQGSAIRSTEGAQVGRAAVRTQAQRRHGAGHQSAPALCLTTALSAPHSPRSTLALSTFSFLTSFTRLTSPFPSKASRNESSSEWCLHNTFILAAETWHKLVHHGVIKTASRPGERELNLSVAEEILTSQSFKIGQRHVTVPTIPAIIAGVVTLFLVYTLSTPSSPVSVDSFTPHLATPTEIPVTYYSKPGMSYLELTSNPLYGLPRTKSKFLVEPEQFPPTPLKKHLPDDFKVPDYVPKPVGVKVPGMRVPNAIHYVYGLKPPKHGYSGEQLPYYAYLAMKSAITRLKPEKTFLIRDFDDLLSYPTTMGMERSPDSRKEELDAGGLCPESPFVDRWLNEYHSFRDGGWAELSVHKPWELARYNPEEIQVLNPRAMYWPMWHGNEVDKTHTENDYDFYSTGQYTYHGWESLAMKYLIALTPDDIRKVDTSFHRLVRPLVGPEDDDAYAQWAKEQAKRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJ25</accession>
    <name>K1WJ25_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJ25"/>
    <dbReference type="HOGENOM" id="CLU_641216_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJ25"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="428" mass="45798" checksum="EC497FAABFB16B3D" modified="2012-11-28" version="1">MSSSGLSSQLTRPVTMSHHSGTVSETASSTSNPVATPKADASAPALEALVHELRQFREDFAPRADELNPYDLPSTASPSPRDRALLVQVQQQALQLAAAEYQLLSAKRDAKDLRSALDEANADKARLQRQLALNTSAKSEIATMDVVQKEFTKLKRYLDFRLEHFIGQFSTSTPSRAFSSAPVSSPTAFVATKGSSLKTQATATRQPLLHAWRFETTTSQTPHRLDHPDDCNCSVACLQWGEVSAAETAIMGKEALHGNPSSYSNYMSPISAAILKGNHDGQNCHCIICMQWSTPPSPAHCGSSSGYACSGFGCRSTRAQTTDKADREGRPSHSAKSSIHSSHSTSNAPFNSRLGQPSGKAFGNDSHSIMLNYMLNSNAGSPAGSVNRVSTRSRANSSAAVSSWTPPKAPSVCPPPSSARWPTSLMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WN04</accession>
    <name>K1WN04_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WN04"/>
    <dbReference type="STRING" id="1220162.K1WN04"/>
    <dbReference type="eggNOG" id="ENOG502QWCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403420_0_0_1"/>
    <dbReference type="InParanoid" id="K1WN04"/>
    <dbReference type="OrthoDB" id="3189033at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="682" mass="75106" checksum="C5C871308223E261" modified="2012-11-28" version="1">MRKLFLRLARYVPSPFAPSSSTSTSRTAPPPRPGSNQAPDPTPKPSSGPSTAPPPATGHRAVKRANHPSAFFNHNRAHRLYREHRWHRSLRAQHLLRLPRVLQSASEAHAHSNAASAELRRARSPNSGVGTGALGPLRLVARSKFRLLRLRWEPTATTTAGPQTLRPASAPPLSYLNARHRLRCPSENAHSDSEPSTTSVNPTHTTPTTPAKFNALTTSTLDRLFDALHFAMDERHRPPTVTYAERSPSPEPTPLPAGHPFASSIAVGSRTLVPPSLPPRAASPSPSVLSQRSTRSNRSQRPPSPDHYIRDPHRLVAYVLPFPQPQLNADVPAPPLRFLIYTPPPPPLLQPPEGEKEKTTTKVQRKWQEEVRAAHESKDKVASWRGLKSRVTKGVNWAVHRTTTADLDFLTRIPSDGEKFRRAVKDSKDKKDDTHPKDSAAGLLPNPEGLAPPRSSRSSMDSHVSATDDEADTTSATVKLEEMVLIYPPSMEQSPEQIREEFVNSLLRTKSKAQRDAVIATGLLPVSAALDWALVFVGWVFGGALEVDAVWAASSFRGAKIARSVTKRLSSSVPSGDASSEDSLRLSFVPSARVLPLQAYLGCACAEVNAKRFAWPQHLPSEGEVLETMGWDVAAHHTNWEDEAWERDQVAEDLKRTMDKAAKAWDKWCSAYEKNPEKAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRW9</accession>
    <name>K1WRW9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small monomeric GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRW9"/>
    <dbReference type="FunCoup" id="K1WRW9">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRW9"/>
    <dbReference type="eggNOG" id="KOG1673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_0_2_1"/>
    <dbReference type="InParanoid" id="K1WRW9"/>
    <dbReference type="OMA" id="IWDRIFL"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="191" mass="21104" checksum="2A8A46B3893B087F" modified="2012-11-28" version="1">MAEQGGYASSGSGSGRVSGSEGGDRNAIVLKVGMVGDAQIGKTSLMVKYVEGSFDEDYIQTLGVNFMEKAITIRNTEITFSIWDLGGQREFVSMLPLVSNDAVAILFMFDLTRKSTLNSVKEWYRQARGFNKTAIPVLIGTKYDIFASYPREEQEEITKQAKRFAKAMHAPLCVIPEIDQVGEPILLYQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRX6</accession>
    <name>K1WRX6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRX6"/>
    <dbReference type="STRING" id="1220162.K1WRX6"/>
    <dbReference type="eggNOG" id="KOG2846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043850_1_0_1"/>
    <dbReference type="InParanoid" id="K1WRX6"/>
    <dbReference type="OMA" id="KEPENSH"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="4">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="395" mass="42465" checksum="1894911C2DE6B6B6" modified="2012-11-28" version="1">MGVFSWFSKSGSKGYEERLAKLASEIEAAKTHLSEVRLRERRFKLAINAYGIGLWAIWVGLWYFDQIPWGLVGWSSHGNEARAVGTAIVAAGPILLLSIIFTRIRISDETRLRLLLSKQRTAIDEIKKATNYDSTRKLIEQYDETGGPQRGQQRGPQSAPNTPPSAGSGPSTPNNAQGGQPGAPNAPGPQGPQGPVGPDGTPRAPGHLAGGTPRRALLADAHAGDPADPPYAREEVCKRRRTSTRSCAASASGTTDWWEASGSGSVCVGEFRRAAQAAENKYALVCAECFRHNGLVGSKREWERMRCNHLNPSPLQRAAEAGDDDMFSTPGPIDTPSKPVTLRSAPSPTPLRRRLAGQRAGPGSSRLSTEVFSAQDDSDEEGDSVDDAMDVDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUF3</accession>
    <name>K1WUF3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase (NADPH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUF3"/>
    <dbReference type="FunCoup" id="K1WUF3">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WUF3"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_2_1_1"/>
    <dbReference type="InParanoid" id="K1WUF3"/>
    <dbReference type="OMA" id="GLMPINS"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="345"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="608" mass="68184" checksum="D1E64891F1CBADE1" modified="2012-11-28" version="1">MTHLTALIESQKGPVHTYEFFPPRTEQGFTNLLDRIRRLTLPPLRPPVAVSVTWGAGGSTSDRSLELADAITKMGVEVILHLTCTNMPKEKVDTALAELGITNILALRGDAPRSDEYATDADANMDEFQHADDLVRYIRKQYGDYFCIGVAGYPTPHPDSLDADDDLKWLKEKCDAGADYIITQLFYDVPAFADWVQRCRQAGIAQPIIPGIMPIQSYSSFRRLINLTKCTVPDYIMQELEPIKTNDAAVKQYGASLATEMVKKLMASKLVPGVHFCTLNLEKSVRTILENLQWNSKKVHDSIHSSPVSRHNQLISEEALEMDDGEEKVPLAVSAADVAQWVKNTREHTAVGGEPSWDEFPNGRFTDVRSPAYGEIDGWGNGLKITPAQALKEWGTPATFEDLSDMFTRYLRSDPGTPTTPFCDMPLSPESQTILDSLIALNAPDKRYWTVGSQPAVDAARSEDPVHGWGPPGGYVFQKAYVEFFVPKSEVERLEKKLAGEKSTLFSMYAANRQGDTAGNTDKESVNAVTWAAFPGQEIVQSTIIEELSFLAWKEEAFEIWDEWARLYPRNSPARKLIENVSDEWWLVCLIHHNYKDTEGLWRFLLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WW77</accession>
    <name>K1WW77_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000159">
        <property type="protein sequence ID" value="EKD05029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WW77"/>
    <dbReference type="HOGENOM" id="CLU_562822_0_0_1"/>
    <dbReference type="InParanoid" id="K1WW77"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="53355" checksum="0AFF9941812C9A4A" modified="2012-11-28" version="1">MELTSQGQPLGQLAPAGQPPSPPPVPLKTRRVGDPDVLSRCPETLIAEPVPQIALQPSWQLDWFGATLQSLPDADSDSEDHRNRQAGVDPQRGREAGDEEGLEQEHQEPIYMSIGAVGEYLAEEARRFPTHIVARWGPAVLSELVETATLEGRPMYKLEAGIDLRRHKLLLFLGPPADSHKHAGNYSITPGEIDTDAIDEFLQKGDFSLIKGKANKLKTYHGTAVDVHDRVTSGHLTDKQQAVNQLMAKEPCGNTQHLWTAMLESSAYDPGVHEELPFAVRHVLEHWNLACFGLTDASSGGLNINVMDQSSHETLVPARQIVDVIAALEELVNDHPLACLPSLKDRDSWSQLLAPFFPRKTPAVVETVVSAVTGGHRRHLWRKTVHPHLDKLFSLPPVSYSRFLPTHSERWHKNRPYISVPVTREPHLTPAGILSSMREDMEQAAVKAGYPPIQRPTVVPPPDTPPTQGSPTQAPPTIAPSTMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXX7</accession>
    <name>K1WXX7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WXX7"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002805_1_0_1"/>
    <dbReference type="InParanoid" id="K1WXX7"/>
    <dbReference type="OMA" id="KELVWRW"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1524" mass="165791" checksum="7DA1FBF94E8EA924" modified="2012-11-28" version="1">MAAPAWQTDELGEEWVETSPSPPSSPTQQTSTINNASSLNAKRGSLRSLGQGAARALPPSRKNSLGPDYARSPSNPLIRNVSGMLSPPTSVSGASSSGDEDRAATAAAGTFQIKDGEDSHGKAFPKSNPFGQGKDMFSALALERMFEPPSPPVQTSSAPTSPPAADKTGDTIAADISTSPRSVSAPTKTSTPTSAPFAGLDRRVSHPYAPTCPSRLSKSMTPMDASFGTVTESEQRSTLLPLDHSGVDDEQPNLLHLGDNLETQSDFDHSDLLRSPSPSDSRSKSRTRTQSRSPSPTPRGPTPVESPTRSPTGHSFGTTREISTQSLLKESEDAEQGEEDDRQPSLDKDGFAFTFTSPVRRESGISRPSFSPDFSPLKNGEPSHSTLRSKESKGNPGGLRLFRNTYDTYTREHLSALVDSIAIRPSPSPPSMPNAKDLRDWSPEATRSPVMSGSSSESRSLSMTPDSGTSLSDERSSKRLRLSPVSPRPRGPAAVRDWKAQGAALMNRIRVSEPDYSSVTSDSRSSRSRSETPSTAAERTESGIGGPTVDYDAIPNIPTPAESEAEDARGTMRSTKSSQRVVNRGSMRSETSKNVGSVGSDGKWRSNPSTTSSTYLHRAEDMMARIKSRKVSDSTSTNVVSPEMGPEKSLSTNSYSSEAESHIPRWRSPDDDRSSNQDGARSSSRTSRTSVEGAGRPPNVNRDDLNRFISSSTLATATTASTSFVKHAGPRDPSKMRAGMTMIQPGDVQNLMSDRIGKMRYDPASMRWIRDTNDSLGRVDEAGESRLGASDDSADPFAGIDSVNSVSPQTRITAAFATLADEPVADQDRVSDKSKSESESEADEAAQEEHDDADKTPMAIERPILGQSVSAPVLKTPNVANAGTPNGGLRSALRNPNATPASAMKKRTAWHADVTPRPASESPSMKQRSVSFSDGVMIAEHLHYEEYTEYEEQPTERSWMPSARTKRIQGVLDNMAELTIEDGSPSKARPPRSLSPKRPSTSQNPAVVVDLVDTTADDSEDTVPLPTRSFRSFRSRGGRGDQTFLTECSFGVAHDRLVQLITDVQPFEPYWEQLRTIDLSHKGIDSLARLKEFLPALDEARLNNNAIEYLSGIPSTVRTLHASFNRLTSLTSVNHLRNLQYLDISHNQLDGVSQLKCLSHLRELNCSHNGITDLSGILDMDCLIKLNASSNQIKRVDLEGCKWQRLETLDLSNNHIHSVHGLNTLRSLTSLNLDHNSLHNLEPPAPMTSVRVLRLSDNELNYLDLSFFPRVRTLFADNNAIPGLSRSSTGGHRIENLSLRNQRVQRFFLSPEDLQSVKRLYVSGNKLDADFIPLPVFSLVYLEAAACGLTSWPTDFASRVPNLHILNINYNFLSDLDGLAGLVRLRKLMAVGNRLGSQRYADGLQSAPLEELDLRMNPATLSFYLPIMLPKTKAKNGKRDADGTMTSVASLEADDAAVPANWAALDNQFRKHLPDEWYSKRLVYRGLLMASCPDLRTLDGVVISSGERRKAALLLEYVAAAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY36</accession>
    <name>K1WY36_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000071">
        <property type="protein sequence ID" value="EKD05574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WY36"/>
    <dbReference type="HOGENOM" id="CLU_1876895_0_0_1"/>
    <dbReference type="InParanoid" id="K1WY36"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="136" mass="14181" checksum="754F6658EB52826F" modified="2012-11-28" version="1">MLAVAAAGPKLPSGTDFCLRIAYGLLSLHMPATAPHGSATASQYSTYIQYTKRLSIPRDHDMAARPIGLSAALVTKNSLGQFPVPPGLSSLRSAPKHYGPWGVCLLVPVLEQGTLMLTGATEALQRSASSADPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0Y0</accession>
    <name>K1V0Y0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Osmoregulation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0Y0"/>
    <dbReference type="FunCoup" id="K1V0Y0">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V0Y0"/>
    <dbReference type="eggNOG" id="KOG2141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006786_4_1_1"/>
    <dbReference type="InParanoid" id="K1V0Y0"/>
    <dbReference type="OMA" id="NARKCAN"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="4">
        <location>
            <begin position="268"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="486" mass="53480" checksum="B9F60138F872C287" modified="2012-11-28" version="1">MIGSKTNLLDSFVVLYATLVGALHRAVGLEFGAHFVQTLVKKYHELVQQAAPTAEEAAENENDPSREAFNLLTLIAELYNAGVIGAGLIYDLIRGFIGTSGDTMSERGVEGLMKIVKCAGSQLRADDPASLKDIVTLVQEQTRGKEKEMTTRAKFMVETLVALRGGKTKGLGAEREDVARMRRFLGGMGKKRRLLAPEPLRVGLNDLLSADSRGKWWLVGAGWSGNPLVEQASSLSFDTKKKQKKTAAEAEDEEVLLDLARKQGMNTDVRRSVFVVLLTSEDYVHACDRLNAFRLTNVQEREFVRVALHCCGMEGQYNPYYTLVLNNLCENSYDHRFTLQYALWDLLRELSEGTVKTDRITNVAKSIAYLMGRGSVDVTILKGADFTDLSKQTRQFLDQLMRNLMIAIQGTSPLLTLPKGFKAKDIDLEAVEESFDKALAVPELAGGLAYILQGVKKNPGKGVGELEAEVIQQSAEAAVEVLSKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1G0</accession>
    <name>K1V1G0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1G0"/>
    <dbReference type="FunCoup" id="K1V1G0">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V1G0"/>
    <dbReference type="eggNOG" id="KOG2434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010579_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1G0"/>
    <dbReference type="OMA" id="VCSPAIV"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="813" mass="89871" checksum="165D8F7FA42C2864" modified="2012-11-28" version="1">MSRDNVAVASPRASSLTGKKRPREYETDKDAARRTRSVGELREARDREAFQRQLIGVFVPRALKESAEGNMNNYNDLLSHFLPTPTQPLVQLVPLLPLVRALTAHVSLLMPSLHGGLISAIVNLPWATGDEKFVKSYVGLCGVIVSAHPGWTKEIVSMAVKGLTWQHPTSVPSTITRREYHARHHLLLSHLLSLIPTLPNVLQPLLNRYAPHKREAEVVQTTWVRNCCELIDYCPELGARVWASLVDRMLRIDVEITNRLEDDDDDDEDDEDETGPRAMSIDPFELLICQDAPKDGIDDDDDDSDDDDEGDPDPDALSSDDENEDDDDEHDLAKLAAARAKKREVLRTMRSKLDGMLCYFLRHLEEAMGARERGLSAAEVAAQSLVSGSGSSTPRAGTPRPSSPTSSTPRSSGSSAPNSAVPALATRPPPNPAQSLAHFQTLLNLFSRQILPTSATQHLPFVIFMCSSFSPAHTELFLHLLVLQSLYARTSDQPTLASQPVSLSQRVAATVYIGSLVCRARFVSDEQARTVMGYLLAYVDGKLHSARAKKNDPELPLFYAVCQAAMLIFCFRWRAFTNQDDMEVTGEMDMDEAQGGQWIADLDVLQRAITSELNPLLGCNPNIVSTFAKVANATNFAYCFSIIEANQNAHRVPTSSSLNGSQLGRQRTFARTQSVPNMPTQAAASNIAIPKLARQINIDAGLDDYFPFDPYDLPVSGEFIEHLYRTWDEVAVDLGGDSDSDEDEDEDAMETDEDEEDLPEGRLRIKTKARQMPKENSSWHRHRDLMDGGISTSFETMNLSPRFSGASGVTSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V348</accession>
    <name>K1V348_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_07373</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V348"/>
    <dbReference type="FunCoup" id="K1V348">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V348"/>
    <dbReference type="eggNOG" id="KOG1429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_2_1"/>
    <dbReference type="InParanoid" id="K1V348"/>
    <dbReference type="OMA" id="EVFRLWC"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="17">
        <location>
            <begin position="93"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC98359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="411" mass="46966" checksum="284BAC315BC32630" modified="2012-11-28" version="1">MQQQQEKTADITTVGHNKFGFDSEMDVATLRSLYLAPSYIKEGDKVENLTPTPHKDYGSESVYDKESNKIQYTTFAKFPPVRLLPNAERKRILVTGGAGFVGSHLVDRLMLLGHEVTVLDNFFTGSRTTVSHWVGHPNFEMVRHDVVEPFLIEVDQIYHLACPASPPHYQYNAVKTIKTSFMGTLNMLGLAKRTKARFLITSTSEVYGDPEEHPQREDYWGHVNCIGPRACYDEGKRVAETLTYGYMRQDGVDVRVARIFNTFGPRMNPYDGRVVSNFIIQALKGEDMTVYGDGQQTRSFQYVHDLIDGLILLMNGPETRPVNIGSSHEFTIMEFAEAVRDIVEEVQKEEGDFVKRVNIIHKDMPTDDPQRRRADTTRAKETLGWQPQWAVRQGVREMVLYYRSQMKQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3Q4</accession>
    <name>K1V3Q4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3Q4"/>
    <dbReference type="HOGENOM" id="CLU_1687974_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3Q4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="156" mass="16948" checksum="7560277645FF8E02" modified="2012-11-28" version="1">MPIPLSTVSFTPPPHLSLAAILALGSIVLGRTVLLLWSRLGGGTFDATLVELFAREKLDKLAQPVPYSVKDLEAEALQAEAMQKLSKAEKLEKPAVPPRPSPKAKPERTQVPADVYLTDDEIMSILYTSATFRESTSVLGYAPDPLLPPLIEVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5X3</accession>
    <name>K1V5X3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5X3"/>
    <dbReference type="FunCoup" id="K1V5X3">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V5X3"/>
    <dbReference type="eggNOG" id="KOG1453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003874_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5X3"/>
    <dbReference type="OMA" id="DKMWGLQ"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000160">
        <property type="entry name" value="Signal transducer, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="968"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="663"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="825"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1234" mass="132846" checksum="3DC1C212255E9AAA" modified="2012-11-28" version="1">MTEVDSTLAAPDLPRSRRSSHRQSVNGVNQEAMSSVTSLGEMEARCGGCKKVIDQENGGIVVAFGSALWHVDCFRCAKCNEKVSADTNLLLLSDGNPVCGNCSYQCFVCKQAITEEAIMTGDESYHAHCFTCRTCKRRIEELVFAKTTQGIYCMSCHNERVARSRRHAEAKRQRAARKERERAEAEKKRAEREGGTDTVSPLPGGVARLPALSTSTSLNLLASGAVQPPQDRNSSAPTSPTFQSNVRPASPQRSLSGPYSETQPTGKPHSREPSADRGSSPTTRTGARPGSPAFVTPRQGAPPSLDTTQVSSRDWSSDNEVSRSATASPVMPLSPASPYAVTNVGTPGGTSVQSSPSAPNLSGSLATPQRNPSPMGPRSPTNTPGLSPSGGGGAGLGVPTTKASKRRSINPGMVFSVDGAAATFAAEPRAPSPLRASSSDQPSRSSSPSTVTSPTRATNVSAESSEATIKAAPALDKGRSSPAPQSPETIRVSVPTEESPEGKAGPRISAPKLGNMSFSLSDPDFASLLQEMESSGKSAAEIVAVKEAREKAASSVDSHTSQAPSQAATGESSASASPESPAVVTISHSPPIPNGSDKMPQSQGLLSPSDSKLPPAGTPRRRPSVESAISVRMDPENAIITLKELVASAAPDATEVAVDLTLLNEIIREHDNLRDTATMLKNKYTGAKRSSQQYSEGLTIAGEEYDKEVALRRELEAENSRLRAQVHGQTARLSVISSDERRAESMRRRSQDLVNSLSTLERDISRLRAQRDISLAEVEELQATKGGVATGEMEYVDDAPGTLGHSLSRRLETIKEQYRDEIGPLSAQREVLQREINELRETKQQFLEESTSLAAKNEELAELNTQLSRQMESMENKLKSTSAAATLKPALHGHKAGSPSMSSLAPTLPEVQEETARVIRVPKPEPIEAAPARRFKWIKSNAGAKLTAADREKKNGGMRPSTEVGLREHNFQQHSTMRLGRCELCQDKMWGLQEVKCGQCGIVCHSKCADKLPKSCTGKEIKKEPIDEGPLPPSMFGRDLTEQAIADQSPVPVIVTKCVHAVEANGMEYEGIYRKTGGSTQSKAITQLFERGNYDRFDLMDTDSFNDISSITSVLKSYFRQLPNPLLTHDLHESFVAAANIRDPKNKHQALCALLKELPTHHYNTLKVLMLHLNRVTAKSAVNLMTSQNLGVVFGPTLLRSKDPGREFGDMAGKAMSVQWMVENAQTVFQDERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7K8</accession>
    <name>K1V7K8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7K8"/>
    <dbReference type="HOGENOM" id="CLU_1116418_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7K8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="28031" checksum="463A238BB4DFE231" modified="2012-11-28" version="1">MHLQRDCYCPRCGTRTITSTDIEVYEAATLACDCNTTLVISDTLDNVPETLNARLPPCEIILKTPTPTIWYPWSTDAFRRSRPALGRVVASLPLVPVHFYLQIPDTHLPELLAYHDEITEDRDWSTAPLLLEQLLDLFPFVSNAHDADDNKFMVTESGAQWRGRAIGSHRLFTVSSVETNEPLDPASCVLSLLDGRVRPHTRASLVALRIMSTSPLKAKEGPRELYSILRQAEAVWEKIKRILARPTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA90</accession>
    <name>K1VA90_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA90"/>
    <dbReference type="eggNOG" id="ENOG502QPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016744_0_0_1"/>
    <dbReference type="InParanoid" id="K1VA90"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="923" mass="102557" checksum="FFD92FAB1741A2C8" modified="2012-11-28" version="1">MYPNNNNFYDPPSDPNAGPSNLDDRDLQPGRNRSKTLTTIHSAVSQATLTNNNSTPPTPNPANDTGLSQASLATAPQRSTQRKVRTVPPSAINDPPTPPLASGPTFDDSVLRPPRRPKRVRRYRHYLSDSGSSSCASDESSDDDDEPPWWTFTQRGMNRLRSVAHPSRSGTGAHDASEIVTEPESSREGGYIDWRHRRKKDRGSGTPPTRQNSGGHTPKSSAARLFDARHFRTARSSRNQSVDIGGGHSTDTGRNKSTPMLDRIDTNLAPKVTRSNSAPISPRSKSPKAKADGPYTADGRPLVRTSSPEGLERLSSDLTDSLPVSPLAKRPRVKRFLTAPIRRHSLDGADNYTDSEATMLASPRLRARQRLFGLNSSMSGRVPEEGIETPPSANSASRMRRLNAQHLRIRIPPEMKQHLKHGFHAGSWQDALRYGTLDSDDMHDNYFDAGHYHRNSDPIAGLGKEPKMRAASLDGHTSALHSGVTPTPVSTRSSNGRTMSLNGHSFLPTPEAAQEAREQRKKERDERKRRKKYKRYQPQTLPPPTPGGPMNLMVPGEKKALGRENWGTANNGLPPPDPETNPFDRLNAFDRIDEETRSFTSPNNAILEKQSPRSWAPWWFGCCRRRRAHAPVDDLDWRTKMRRMLFLDARITIYIRLVNLGMAATLLGLAITIRLMLISLNIDGVIGPSTTLIIAYACLTIVHALMAIYKEYFGRPIGLWGLRSKMLWVCLDLLFIALWSSATTLAINDYINTPLDCTPMTPWWTSGSDYYNYQYSYHPQRLAATTGTGQAHLRAPDWLLYGVDSLPPALLREHDSLPVQDLRDGPPHSHPDQEHQHRQQQQQVSRMGEAYQPVSPSSHPSALRGSPALQSTLFPVPTLPFCVPTRPAVSVQSTAPSDQQSLFSPQLPRFPRSPRSAPSHADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAV8</accession>
    <name>K1VAV8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="4">2.4.1.132</ecNumber>
            <ecNumber evidence="4">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 4">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 4">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 4">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 4">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="4"/>
    <dbReference type="EC" id="2.4.1.257" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAV8"/>
    <dbReference type="FunCoup" id="K1VAV8">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAV8"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAV8"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851999" description="Alpha-1,3/1,6-mannosyltransferase ALG2" evidence="5">
        <location>
            <begin position="30"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="6">
        <location>
            <begin position="171"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="423" mass="46319" checksum="D1FE1E682CA62286" modified="2012-11-28" version="1">MTIVFSILRNIALTFLLWFSQVLPPPAGALNPLAPLPAFDVFVVDQQSVCVPFLRLLTGTPVVFYCHFPDKLLSGGWQITFGDEVNLSRNSGGLLKKAYRWPIDTLEEWTTADVILANSKFTSRVYSAAFSSLRKRQPSVVYPCIDVDAYQGSSVRKGKAKAEDGVDLVVSERPTVISFNRFEAKKNVALAIESFADLKHSGLIPEGLSRDLRFVVGGGYDSEQTDNVETLRANQALCEKLGLSYHTLWTTTDEPAPEGTDVLFVLNFSTAQRSALLLSPHTLALLYTPTNEHFGIVPIEAMACGLPVLACNTGGPTETVVDFWEGATGFLRAPKSEEWAPALARLVSLSDDERRTFSAAAKKRVREQFSLETLGREMDLACREAVKLGNPQIAIGNRLIKYGLTLIVLSLGGLFVALKFASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBB1</accession>
    <name>K1VBB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHLH transcription factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBB1"/>
    <dbReference type="STRING" id="1220162.K1VBB1"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_683677_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBB1"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="403" mass="45176" checksum="62995C26D795CD98" modified="2012-11-28" version="1">MNRAPSQRFHPHQLDAHPSYYHQDAYYNPHPHNYHPYSKPRHYRAPPPHRLLSPPPSRERRHPATLLPPIETGFSHHSSSLTDAPPPLTRRSRASSTSHHHRPRAAPYPEYSARRTLSPPYRHHDASRSSRYPPELSPPGAYYDRQCDDILFPLTPQSAKFESPAMVAHDSRDHALDRLPHLRISERDYDIKPKASGYASSEDDYPSTYRAMSPAERRFLQTVVPEQRRTVTAYPVTGGYSWPPTAEVATTDAQQQQQQQQVTDEQKRDPNAMALDPALSSVRSSADGTAAGNGAQAPPELRLIPETLGSAAAESPAADVEIKEAIAQVPAAQQALAPPELPKKETPFSRSPELRISHKLAERKRRKEMRDLFDELRDALPQDRGMKASKITMRSPGGCENGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCI8</accession>
    <name>K1VCI8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent Zn protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCI8"/>
    <dbReference type="STRING" id="1220162.K1VCI8"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573884_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCI8"/>
    <dbReference type="OMA" id="PFFEDSH"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="278"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="476" mass="53531" checksum="05792DC327E549DC" modified="2012-11-28" version="1">MLAFFLIVLAAVHAAQIPFFEDSHDRKPGAPEEIFIKQFSALSGNTGVALQSRLEALYANSTVLTTQTPFDLLAFADESGLKLRQRRDLAWLTLRGYSAGRSNPEDDDDLGAPGQAAQMARMARQAGHARAPEIKLGVLDAQEEGEDSIGNDKSNEAIFDSVHMAAWELRWEDTDMLVIVAQFAQGFSFVTQWHLVSPHASAADSLFATVAKATSAHPDVVWVFDRGWWEPSKDLWRDVRRSSWDDVILDADFKKNLREDYTGFLKGRKTYKELGVPWKRGLIFLGPPGNGKTSALKAIMGEVGVPSLYVRSVRTQENLATIFKGARDMAPCLLIFEDLDSMIDDDNRSYFLNEVDGMDSNDGLLMIATTNHFDRLDPGLSNRPSRFDRKYQRRDYAVYWQKKLKGVSGIEFPNALLDEFAAKTSRFSFAYMKEAFVSSLLAIAGDDKNKGDKHFPQRLMREVKHLRKEIDDGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCQ0</accession>
    <name>K1VCQ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCQ0"/>
    <dbReference type="HOGENOM" id="CLU_928092_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCQ0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="300" mass="33413" checksum="77A74FCDEB84AF30" modified="2012-11-28" version="1">MSCSLILVPVPIPDFAKPAPPNCCHLLASQRQSLPTISPPVTPIDKLVSAVTLQRRANNQMWRDVVLPSLKSTPSRRSQQETSQPAQVDKEHCLAPNGSSSAWRPPFRSQSNVPSRDVQGSLIATHDKVPFGDAPERIQKSPVPKLLVSRPTPLGRIDEENVTSGTARGDESPAEADAALHEPIQEWPMPSGVWADDYGDDDVVSDVWRRVFSNEIRNLELRSIVKNWPAATGYWASSLRYDESISWPEDWCDPVTAAALLEREDGVEFRSMPEGQPKSSGRKGKKRKRKNNRWRGSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD53</accession>
    <name>K1VD53_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD53"/>
    <dbReference type="eggNOG" id="ENOG502QU4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033925_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD53"/>
    <dbReference type="OMA" id="LWTRGNW"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF82">
        <property type="entry name" value="NIPA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="518" mass="55857" checksum="9B7A6E0DEC42E1AE" modified="2012-11-28" version="1">MSATDVLTEAATPTEIATSVASTLEALATAVTAAATAVTDEAQNVTLPLGLDGSDVTQSTGNYVVNTIIGLLIVLGASVLNAFGLNLTKLDHLQNSAIPKAQRKKEYLRPLWLGGMGIYILSQVLGSPLALRYLRPDWVAPLGASSLIFNFVFAYFLVGTPVTTSDIRGTALIVLGVILILVFSSINHGLRDSLSIDELSALWRRPSWLSYFFFLTAATFGVYLISDVLAKVSKNRASLDSLPSPELPTTRFGRASPGANGSAIAEYWGKGKWIFKYARGTFQHYENIILRHMEAMLSRTSESRVQWLEGIGWAVCGGSLAGLCIIFTKAVVKITWLPGHPIVCLNRALVCADTVTVVPLFYAGYTVFGAINALIFYDQTGAYATWTLVCVFLSIAVLISGVRTDDDQAAQGPQTTTTVDADPAVRLHPRQPTDGGENGGVLWTVGEDEDESDDEDKKEGPGVGGTNTEGERGGLLLVHDEDERLHSPARRASRRLEDEEEAEFGPFASPMRSPRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDR8</accession>
    <name>K1VDR8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDR8"/>
    <dbReference type="eggNOG" id="ENOG502S8U9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621411_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDR8"/>
    <dbReference type="OMA" id="ANCIREI"/>
    <dbReference type="OrthoDB" id="2595594at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="47952" checksum="1FB5407E8C1218D5" modified="2012-11-28" version="1">MQSPGSDLLEVRMMGLNKSITTEALGEFLGKGVRVRGILLHPQTKGPFQWAQVWVGTENEVIQLLELRDVLAVNGITINRAIPQQSFTTPPQMSWDILSQLNRSARSPTTPNTPFVSTPYPQSPFGLQALQGSPFFPRQEQSPTLPRNLYVLNLPLDLTHWMDLGVAGKFGRQPITDNSGFVLMSSHREAVEAMHQMHGNGSKLDVSWALVQREAKNMLNNEAELRLSLTGGSLPNRVVHPPSVSIRREAAPDCSVIIENLDSFLFPDTDTVSSIFKTFGPIQRVVKLTDSPLSVLIQFEHAVSATALVNANGLQLGDRVLKTRPFAAPMTPGAFDPFAEASRRWLDEAGYKVGPVLPQTPQSMPPRGTRLSADSVPFVPNSKADESPLAHVGKMVGKMKAALANHVISLDSDSSDSGKESEHSDVGCDQASAQTVVAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE41</accession>
    <name>K1VE41_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE41"/>
    <dbReference type="HOGENOM" id="CLU_2591480_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE41"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="80" mass="8375" checksum="53F7D811F4550AF9" modified="2012-11-28" version="1">MQHPAAATSIVVEEETREMVACRLVAAGVPDLAGQDQLIAHIAATAAHESPQGQGLIHELIGNPPHLGEALQVRREPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEN5</accession>
    <name>K1VEN5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEN5"/>
    <dbReference type="eggNOG" id="ENOG502SFIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085468_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEN5"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="284" mass="30797" checksum="C9D61B69172929DB" modified="2012-11-28" version="1">MIFLPRAIQRRSPRRSTQGAGGGGGLGEVEADDHLIGAPPRGNRSVSLIELPTSSSASLTFQYRHPQRGRSSDLDHLTPTSVLSMIPTSVTRGASRLPLTTKRGNKDFYKGTRQAVTPGAGPRTGAPGKHVIRGKAKYRLLDSRVRVFVGPGIEAIESSSSDLSSSRSINPRPPLSLPSSSPHPQQLRARQANPQLKPYVSSKATVPEQTLPPFGPWPKTSSGVAPQQRDFKHFSKAYNALSPDERNALIMQARREWYAALTSTAVEKGQQEAHTQEVEGQAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VER0</accession>
    <name>K1VER0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VER0">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VER0"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254362_0_0_1"/>
    <dbReference type="InParanoid" id="K1VER0"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="729"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1400" mass="151420" checksum="E1BA4826547FCBC2" modified="2012-11-28" version="1">MAESLANFNLHACGRPAPGRAGQQAPFPPIPVPTIPTLRPLPSRPLPPLPLASPSPRSLPFQQQEGDRTDHPDQLAPQPGQISPISPSTALLPLPGTSPTLNTPSSTSAPSAATSTIPPSPSSPSTLSSPRFPLPPNHPPTPPPRRVKDKDFDPAATPRRSANDVVYVPSSDQDHSEHVSTSVTPATPVDEYDGYEREQYELADDELSHEHDSALAAHEHLAQQSSPPSTPPRSMLPRHRDHDDALDVEGDNVPGSSPRSVSSSAARQRREQRQASASSATDENGNPIPVPGERRESLVSNDSTGRSSTHRAQQRKMMLAQQMSLGIDAEIKAEDAAQQPKRRSIFRTTGTASTPDLTTFIRGKGKPQQGKQAQKNSSAGNVSQHAMGQGKSSTPASSTTAVSSQFTTHHMSGSTSSLTRGRSHEAPSDSSAQRGAWHGHNFPNDSQRHMQTIAENDSLHRKQSFNDDGKLSLSARSNAEVSSPKSNVSPQLPSSFSPQFPGNAQFTFESPQSNGNARPPLPQRHSGGLVPGMAEPHEPSRISISSAHSAQEVIVDPQDPGKEPSTRVHNMLQRGATEERSSSRRSTAEAEPKPPRRASTSFSDDVTGLLDRISHGDPPVGVGIRTQEPETTEHLQVSPDPSRYSQRSASPLSPANQDSTTLPDAAPVPVSGKSSASSTQSSRYDDAQAPEGTTVLESALADNSDTDLVPPPVPVKGEPTIKMVPTRHDDGIAIEVTQSPHQSTTSLDDLPADEEERAHQLAREFYQGDSAHVSTDKVAIFLGGPKPVNTATLRHYMQHFDMRGSKLDQAFRDLCAKLHLKAESQEIDRIIEGFSARYFDCNPNTVFGTPGVVHTVTAAMLMLNTDLHIAELQKHMSRADFVRNAMRAIQESMPEDLESHNDSGSLRGVDGTSTAAQSTTSITRLRQPANSRNASGTLAPASELSSPSSQDLRSRAASSTTVNSFTYSKQWEVEAESALKEIYSNVRNEKILLPIGSADKSSLSLNSYNRRGIGPLKRSSVKGNSPYNGSGVFAHSDGRLSPTPSYANSIGEQTIAPAIGFAGNLSHTVIREQEDETHSIKSNQSTVTLEPLNDDELALLGAPWAKEGLLSRKIQVEAAGKKHQKKDWKQYFVVIQKGDLHMFVFGEKGSKGPSMGMGGMGGGNWLSNAKTTGEYSLMHAMAMALPKPGYSASRPYCFTVTFPTGEISVYQAGTEELVAEWVATCNYWAARKSRQPLVGGVSNIEYGWTRVLDENGDGTPPPEAPSVISSRSSPSMTRLGAMRSRGSQNLDKMTIVEWKPPPHATMPSNLDEEAQLEALLMYVQSLKEELDQHKSIEEPMSRLYTPGSKNAVKARENWTAKSRYIHSEIFKYETYVEALRNAISLRMLKQQERKAAQPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF01</accession>
    <name>K1VF01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_08080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF01"/>
    <dbReference type="FunCoup" id="K1VF01">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VF01"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005230_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF01"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="671"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC97621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="840" mass="94999" checksum="0F32D123438AAFB3" modified="2012-11-28" version="1">MSLIQLYIPTEVAHDTIYELAEMGNFQPKDLNPDLSAFQRPFNHRLTRLAEMARRTRLFNKQIKALEPPIGIPPLTAIPPFQCVGPRAQNAFDELDETLKEHERRLAEMNKSWEELGKRKGDLEEKKWVLRETAGFFNEAENRHTEIRSSFDEGDGTTPLLEAAAEYGTLPGEGIGAGGFDLEFVAGTIERTRMPTFERILWRVLRGNLYMNYSEIEEPFVDPVTGKKTYKDVFIIFAHGDELLAKIRKVAESMGGTLYTIDSSPDKRADALRETQARLEDVDAVLYNVGQTRRVELSKIAENLESWRDAIRREEDIYKTLNLLSYDPGRKTLVAEGWTPTRDITTIQLGLRRATETAGTSVPPILSELKTHQMPPTFLRTNKFTAGFQALIDAYGIATYQEVNPGLFTVITFPFLFAVMFGDIGHGILSVLAAGAMILFETRLATAGLGEMFEMFFYGRYMILLMGTFAIFTGFMYNDIFSKSFWIWQSGWQWPEKIEGPVTAISTGRVYPFGIDPLWSGAENALIFINSYKMKMSIIMGVIHMSFATCLNVPNFIFFNKRQNIVAEFVPQILFMWCIFGYLIICIIYKWSIDWSTADTTPPGLLNMLIYMFLAPGTVPDGSWLYPGQGFVQTILLLVAVICVPWMLCMKPYLMYKEHKKVQGQGYVGLRTDGEEEEAPRNSTTSGVDHGEEEETFGQAMDTGGDDEENPHDMGDVIIHQVIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLYDMTLQKIGFEWEGSAITGAVVIVFMFAVWFTLTIFILCLMEGLSAFLHAMRLHWVEACSKHYMAGGYPFTPLSFTENPADDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG32</accession>
    <name>K1VG32_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Na+/H+ exchanger AnNHA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_07683</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000399">
        <property type="protein sequence ID" value="EKC98021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG32"/>
    <dbReference type="FunCoup" id="K1VG32">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG32"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_2_0_1"/>
    <dbReference type="InParanoid" id="K1VG32"/>
    <dbReference type="OMA" id="HEQHTID"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="105"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="533"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="759"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC98021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="819" mass="89874" checksum="24AE08BDA2C3DF73" modified="2012-11-28" version="1">MAFHPFEVDAVHLAYTILGAFVVIFGLFSGFIKEKLYLGEAPIATVTGIILGPHVLGLFDPIGWTHEQHTIDYITLEVTRVVIAIGVFAIGVELPKAVVGGKFADKHVPSHIRHLLSAESGCNDGAAFPFLYIALFLTLDKSAGHAVGEWFYYTWVYEIIMGTLIGTLLGWSVRKVMQFSERKKIIDRQSFVAQYVSLAILSIGICTLLGSDDLLAAFACGTAFAWDGAFNKATEDSMFSNVIDLLFNCACFIYIGAIIPFKDFGNAAFHLSVWRLIVLAILILLLRRMPIILALYKFIPDLKTFHEAVFVGWFGPMGVGAIFIATLARHHIPEPVNDGDTSQVDLLQETIVPVVSMLVLASVLTHGLSIPFFMSGRRVHTLTYTWSRNPSIATNNEPAWTTHARRIIPGQDVEINRDEEEGDLGMQHRMEKSSHGDTTDSSHSGSQTRTIEGQGEKITEKRTRDGEEHVRVVNDGAGTPPIAEYREGHDLIIEHRDGADDCDVTTHVVKNAFRDNGEPHSKFEEARDVVHNIIHSRPGSRSSRFSRQSRESGHSMTPVASIDSEHAGDGFVRRETGDGKNIIELPPNDSPRPARVDTPPSPRSGAPPVIVTDHAYDSDSEHSTNAGSDYEDNGGRRPYAHLQRPSVSSSRDEPSVSRTQSTRDSLPHVHSYIPAERLAPKKETGGWRRFLGVGRKPQSSHHAAEEGRARPSTPDSDDGGFKRVPTTRSVHRTATLDPNEGGIPLTRTLSRAISFAPDIAPSSDTAPSIGNYGNNAPGFKRNPDLSLFRSSSIRFADDEDDDDNDNGGGQSVSFAEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG42</accession>
    <name>K1VG42_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_05949</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG42"/>
    <dbReference type="STRING" id="1220162.K1VG42"/>
    <dbReference type="eggNOG" id="KOG0530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026582_1_1_1"/>
    <dbReference type="InParanoid" id="K1VG42"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC99765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="435" mass="49078" checksum="FCE4EF19FF0A976C" modified="2012-11-28" version="1">MVISSLRAFDERAPGNDDTRRPNVSSDVSDRYARGHQVDFLFHCFVKLELFIVVGPATALFFLPALQERPSATISTTLIAFPPDIDDCLITTTTAYVPLGQREEWKDVTPIPQDDGANPLVPIMYTEDYRNAMDYFRAVSASGEHSERVLALTEAIIRKNPAHYTVWQYRFNTLVALQKDLQAELELMNEFARENLKSYQVWHHRLLLLTQLSPEDPTPEIEFIHAALLPDPKNYHTWAYLHWLYCHFSALGRITPEMWDKELAWCEGMLKEDARNNSAWGWRWFLRMAPRPQPSASAPAQSDRIEEELSYALSQIHEIPHNASAWNYLRGVLRSTPQGSDLRASILPVLAPYLAGSAVAASGPDDGLSAWPQRTGEVDGDTPTPVPLALECQAEAMKEEGRLGDAAAIYGQLAAYADRMRSAYWEMKREGCVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG96</accession>
    <name>K1VG96_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG96"/>
    <dbReference type="HOGENOM" id="CLU_797372_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG96"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852135" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38730" checksum="45537B7BCE64086B" modified="2012-11-28" version="1">MISGIRRLIVRLFHLLRKLVGLSVSSPSTETAALVDYNCFPHIWDTIVNNAPPESLAVLTRVSRESRRHALSRFTHLYGLYVSAVEPKPRIKAALSYFEGTVSIPLDADHRKKIPHILFKGDLDGRILRLSKLPSDVFNNVEVIDVGCCGAETKLRLLAIPSLRVVRIRTNMTSTFWVPPTVTTVVISGILSIDFIKDTSIDTLVIVFGSLPESHQCMRLSKQIKNVVIICFGDQRDYLMNLWPLLEVTVRIGAQLTLVGSSPSTEPWDGPEALAYSLHNIGIRIWQSPVGHHVRTSGLVTHQDEKEFRAEVGEDAWALYSNVPLPLRCDCTSQGLGQQQGPCLIPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGA1</accession>
    <name>K1VGA1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGA1"/>
    <dbReference type="HOGENOM" id="CLU_719995_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGA1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="384" mass="40668" checksum="04C746055AE9DB58" modified="2012-11-28" version="1">MNEVVRAPHSRGAAGTAAAGWLSGRLYRVVRGGDSGNPTADVSVSLPAASGAGLKTDTTGQYPTKHTHRALAALRLIHDTRHTPNAGRAVVIIHASDTTTLISDISSETPTLLSSLNTSPPSFQLTSTTNSQKPSTLPPPAMDVQTPYALDLSSLLFTAFTLGFTPLLLVGLLFRMAVHPITLLYEWLTEEPKAPPLLTPWSPQYPVPTTPRAASSPRSPYAAPSPLPRGSEGFPSPSLQSRRYSPTLRAQSLRSSAGGGGTYAGPAFTAPPALRGTGTYLNISYSPGLGASVSVGSGSGGGQPAVFGVGLADKSSKYQPTLRHLPPRSAVAQPYRPETISSIAGAQAHASAQPLALDRAFRQIEEDKWDRTERWRREIMEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGJ1</accession>
    <name>K1VGJ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGJ1"/>
    <dbReference type="STRING" id="1220162.K1VGJ1"/>
    <dbReference type="HOGENOM" id="CLU_1518920_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGJ1"/>
    <dbReference type="OrthoDB" id="2596619at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="19632" checksum="68C491DAE6080405" modified="2012-11-28" version="1">MAKFTDKIADKLGDHPVSHHLRGRKWGEMLTSLLFSLVVLALIGVWAAATAGYETASKMSPDWNMTDNDHWFAKFTPPRAPPLCQPAFINTGSEFYTTNGIFLWQMGKGFNVSAEKAFGNNDTTVNFNSTLIIQQQRKLKLNAETGHVASESIRVPSSWRCAFERTCRVPPGTLPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH95</accession>
    <name>K1VH95_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VH95">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH95"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001060_7_1_1"/>
    <dbReference type="InParanoid" id="K1VH95"/>
    <dbReference type="OMA" id="ELGKECW"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="409"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="878"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="917"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1175"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1201"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1329" mass="143479" checksum="F2C2FCBA922A3071" modified="2012-11-28" version="1">MAQAHATTLKRPRTDPPSPSSSSSPKRAASEDTASSPPASLAPATHNAFPSSPLRMDLDDDGQSSSGWVAQTGRVSLGEGDAENGAMSQSDSKQLYDAVLGKSWDTGAQADEAGALPPPYTERSTFYLIPKSYLRDLSQHALDGGEGTPPSLDITPLVACTTPTELTALIPGHESEPQKQLFWRLRDGLQEDEDFIYVGSMGWEALVKAYNYPADSPQLPRLCLAGERIEIAPQTYRLHVVSTEPSIPVPPAAPPAPITITAPSTTTYSELKTFVRALFADKISVGAPLRLWTLDTQESPSSLEIDAKDMPKLSAKMMSGNDKTLADGGFADGDDIVLEVSSSSSAGAVDWPLTADANGNATEKLQPLFGKPAFYSGNSAAGSSTSSLAAFNKPQTRSQSRTRSGHGLVGLNNLGNTCFMASATQCLSNTSVLADYFLCEFSLGALKLISAGVYREELNPDNPLGMHGQVAEAFGETLEALWTSPAHSSFSPRRLKSTCSRFAPQFAGYGQHDTQEFLAFLLDGLHEDLNRIKKKPYIEKPDWKPGGGDRELAELGKECWEGYKKRNDSVIVDLFQGQLQSTLVCPECHKESITMDPFMYLTVPMPITQTRTFKCIYFPKDTDLAPVNVQLLVVPANASFSTVKEKLGQLLQTNGNNIVGFDCWKGGIYAWWLDSDPNTEAKDHDVAIFHDVGVPVTATHKAVGTVPTDGSVTVPVYTFRPNDSPRSSFSRGDSAPSEGCLEPFFITLSKEEAMDPAAVREAVMRGYSRLVKPEQRNALFVKPNAPQAQPLPDVDDEDDEVAEIRVDEEDAEGIDPTMLAPPSVEGIPRSTSSLSIASQSGRVVARGDLFKIYVADAASAESNSSGMSFFKKQDPNVHNLYRGNPSGAQGSWSSLEKRARAKRPVLQRMASSFSNLVGTSNSAAGSAANSDDEAEAEDSKQPKQPAACVRPGEALFVQWKNSKFEEFFEPRREQLLRGLELVVDPAIAKDAEKKGRGRAITLDDCLDEFSKEETLGQDDLWYCPVCKKHQPATKKLEIYKAPDILVICIKRFGSARTLRDKLDHMVSFPNEGLDLDERIGERRITQSLHLTPEEAKHYGIEHSTEPFIYDLYAVDNHFGGLGGGHYTAFCRNKDDHQWYNYDDSRVSKASAEGVQSRAAYLLFYKRRTERPIGGISRIKAEEASRHVTPMPSEPASPVLGPSVPASAMASSFPSMPGTPLQPSPTVSPQGSDDSDDDVPLGRSRAAPATVSDLTAAGAQVGFGNTMWGAAAVPPPTAHGFGLPTPDASDSEAPETSNGEQGLGGSYHVVRSDGTSESAEMVSAPSPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHL6</accession>
    <name>K1VHL6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHL6"/>
    <dbReference type="HOGENOM" id="CLU_053750_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHL6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="422" mass="48464" checksum="59E8CBA0527EB8EA" modified="2012-11-28" version="1">MTTSRSVASDAPHQSKKTRLGPQVKQPLDIHSYPHILDAVIDAAVSNVLRALRATSREMRSLVDQRDRHLALEQMAEMPQKESEDDYDAWDSDSEDGNTTPAKPVWAVTKSGVRFSSLPDTTDVFDIDGPVGSLWYDVVHSNLGLDSDSDDWSDTESEDSAYAALNASLFGPSPWVPQWVQRNGRLFYPDRWPRLVRYPDGFDDNRRALGPLKPDPCAVYFCEFSDFILGLYHLDRHYSERGGVRESFLDTVFNVDLVEDILGEKLWETINPMFEVCQVDPDQWEHPPFFVGLLMVMTRNFIESDEGKATIVGYDTWPVNMLPDPNERDGRGPSTTSADRVRRWIAIHVADAKRKLQEEGEPYSRPETDLDDPIRLLTLEEWRKEIGEEYYKLMTDRYYQYESAKPLPQFKRHPSVEPLDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI65</accession>
    <name>K1VI65_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_02221</name>
        <name evidence="12" type="ORF">A1Q2_06878</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000380">
        <property type="protein sequence ID" value="EKC98831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI65"/>
    <dbReference type="SMR" id="K1VI65"/>
    <dbReference type="FunCoup" id="K1VI65">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VI65"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="InParanoid" id="K1VI65"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="2585648at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="103" mass="11409" checksum="AC5C20A04BCA7598" modified="2012-11-28" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDSVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIH4</accession>
    <name>K1VIH4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIH4"/>
    <dbReference type="HOGENOM" id="CLU_1338368_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIH4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="205" mass="22122" checksum="ACBD4F3F89DCF311" modified="2012-11-28" version="1">MLTQSLTDHRVPLWPPPGRPTSQPRPPTAHDPELEREAKRDLERRSRDRELETLPYPANKEPRLSPARSMVAHPSAYTDLSTSPIALTSSSLSAARRYRTFSSARSTVSSSISGISGRDIRTPSRPRASLPLFSSELGLGAPSPETPRRVSAPLSHTTPESLGAGLPGGPGSPLVPIQFIRKASESPSVRNKEREQLSNLPGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ65</accession>
    <name>K1VJ65_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ65"/>
    <dbReference type="HOGENOM" id="CLU_600187_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ65"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="456" mass="51413" checksum="452AEF11875143E7" modified="2012-11-28" version="1">MTGLPEGISLMDATIMRAYAANGEVSKFREVANTLPSTPAVLSWVSACLKESASPESAAPQQARRSTSDKDATRSRSRKRRASTTITVHTPKVTKREPYYRVSSSPDPIDAVGTPESGSPEPHYNFYASPSPRSVMDTPSRRYLSIVPSEVSSDSKRVAFLTAIIKGLAIATVRGCVLSATKHTDVVDVFGEDKDEMLSYSLRLHCEAQMKKMKHAAVRKICLNAALAHPDVEENVLVETPSHIIEKCLDDDEVEEMGEHFLRRAKFLLRKRGNTGKYSRMDSLPKVARGIAEEIESMLDTLLKRSSSTSLSSESKKACLSTTTILVAACLAPCPPYNYLYPYIKNDHAVKWNTRVRDVMKNLTDKELLQMRNAGYDDQLLRLWKHVRRYTTRVGMVDRWAIVRYKELGQRPPPEPKIWPEFVKKTVRYFAARTGGWNKAWDPVKTTDCFDYEIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ78</accession>
    <name>K1VJ78_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000374">
        <property type="protein sequence ID" value="EKC99191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ78"/>
    <dbReference type="FunCoup" id="K1VJ78">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ78"/>
    <dbReference type="eggNOG" id="ENOG502S5QU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028690_0_1_1"/>
    <dbReference type="InParanoid" id="K1VJ78"/>
    <dbReference type="OMA" id="IHYDRRY"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="329" mass="36489" checksum="73700BB5767C0998" modified="2012-11-28" version="1">MLRLARPLTSVSRAARPVPRFATLTARAQSTSAAQEWIKDMTGRPATVSQDDFDTLRASQFKNTIPTPTEAPAQYGVAKGDELPKGMHLIYFSPTDHFDDLAKDGTSTEYNAPEPYIRRMWAGGFMEWNPNSAIKLGDEVEQAVKVARAEEKAGMMFVYQARELAPKGGDWAVREERTHVFFPPKQEEAKGGAKPGGKKKPAAELPKPDLTFSYTPTSPLLFRYSAMTWNGHKIHYDRDWTTQVEGHPDLVVHGPLNATLLVQMADRAARDAGVKLTRFEYRATSPMYVDKPISINAKWDGEKGADGKLQLWAEQSGKVGMKATATFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJD4</accession>
    <name>K1VJD4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJD4"/>
    <dbReference type="HOGENOM" id="CLU_2414863_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJD4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="92" mass="10114" checksum="1DDB23E904CAD232" modified="2012-11-28" version="1">MPSCTVHFPTTYTAARWLALRSEIVDALHLSNSHDFELDVSFSHGTSVTVNLKDGDEDVARQLERLARDFDGRPADPESDYSSASEGGYSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJG2</accession>
    <name>K1VJG2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJG2"/>
    <dbReference type="HOGENOM" id="CLU_1215534_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJG2"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="26347" checksum="317A13C5B2B31BEE" modified="2012-11-28" version="1">MLSLPPPSVTGQEKGFRLTDSHFEDSATVKLFLDVMSATRNYNVFASLSELYSDSARQLGKLVHFMDKYNSENGIELLRLSCTAAVLHGYCPPSQLFVFASVINDLTLCFRIIEKFPGWTWTNPDRSRVLQPQPHGASEAPSIFLTSHAGFDLSCGMPYQYQWAMTRASLYYDPSKEYEKFAHKFVDIVQIIFDENTQYPVYGGTFPAIVATPNLEGYTKPRASDASTPTLTVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJN4</accession>
    <name>K1VJN4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJN4"/>
    <dbReference type="STRING" id="1220162.K1VJN4"/>
    <dbReference type="eggNOG" id="ENOG502RB6S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1099156_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJN4"/>
    <dbReference type="OMA" id="LEPRMAH"/>
    <dbReference type="OrthoDB" id="2595969at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="253" mass="27245" checksum="F4627BDE285FE7E7" modified="2012-11-28" version="1">MYDPTSTVSAPPPRYLLESDSSDEEGQGQYGMEGVRAPKLRVSAPEISLRPLGEFKPPLQVQNAVVGVGQAGSYLLRSTGGRAKPLFSIEAEGDRLGTAVQLEGGELLVAVKDGKDWDVVRKLLDNVQATRWTMVSTYLPALYIPEEGEEVIQPSVRALPPTEGIASYTAPNYVTGIAGAFLSLAAHPASKLDVSLRLLPLPLSGLPRTALSTLPIKVMRPLWTEADDEPFLAPGMGKRPTETRQEDTGGMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJU5</accession>
    <name>K1VJU5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJU5"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_82_0_1"/>
    <dbReference type="InParanoid" id="K1VJU5"/>
    <dbReference type="OMA" id="NTDARSY"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="260"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="555"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="688"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="833"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1287" mass="141430" checksum="4D02CEAA9B383875" modified="2012-11-28" version="1">MSIDTTEKVLADRRFDTARELVEEIAFAQNRRKLFETLADVLERNSMDIPFAMCYSISDERSSYPNVDLTLEAAIGIPDDHPCCPYKMQVPLPARRRPMAAPMQDLRPDLLHGSPSPSISSRRMSSRSMTSSGGTMRGQSYIVSEDRTAWPIAQALQVRQCVVMDDCSELIEGLPLRQWDMLPDQAIVVPIMNNHTSPSAVLILGLNVHSTLDQAYLDWIHVLRGHLASAIASVTAFETQVSQRLEREKLERAKTAWFRGAAHEFRTPLTLIAGPLEDVLSTPLDGEQRNTIKLAQRNVQRLQRLVTSLLDFTRIEAGRLTAHFAPGDFGQFVENIASLFKPALDRKGIEFLLDIQESSDLVSFDPVLFEMVLSNVLSNSFKYTATGSVTLKVWFDSNVNLSVVDTGIGVGEDEEVGKLYHRTQTAVQSGVGGTGIGLALAKEIVKLHEGELSISQNADGIGTHVLIWFPKDHLETEDYFSVAPIGAYVRQTASEMVLSTIGEEVGSEWSGDTGRDSTSSIGTPLTMGSSQSISGTSSVAAQALGEALMFEKSDILLVVDDNEELRTYISHIFSPFCTVIQASGGDEAYKLVKSHRPHLVLSDLLMPASSGMDLLLAIRSSEDRGIKSTPVIILSAINDDETRLEGLVGGAEEYISKPFKRNELLARVHLHMQMGKRRAALEDLFAQREQEIAVLSDHCPSGIIRADADGRIVYANAAFCEPAGITANDITRDTDLLALWSKCCDADMVELMGDKWAAIFDGEAATTNVTWKWKTGRTMTANFIRLDQVRPNMSGIIGCVTDITYQEERLQEAEQRRIAAEEQKRSHERLVDFTSHEIRTPVSAILQCSSIVKENLLSLQEQLQEDGTIRSSPALLAQVNEDLAALDSIHQCGLVQERIAADVLSLARIQLDMLSLHSVPVDIAEAGQSALNLFKAEAKMKRINMALEFGDTLRETGVHAVNTDPVRLGQVITNLISNAIRFTSTSTVRDITVAFNVAWAPPTTNCLLPPEAVYPQNCPPGTPVYLYVAVRDTGPGMTPEERDGLFQRFHQGNKMIHTQYGGSGLGLFICKNITELLGGRIEVESAVGRGSEFRFFIQTETASMPPPKVVETEIKQLQHIQKMNVLVVEDNDINSTVLRRQILKAGLDCDVADNGLVALNHLLAVQDLPPLTPGSEASINLEPPLSPVGSAGSAQRQPYDVVLMDLEMPVMDGLTAVRRIRQFEAEGKLPGHQLVIALTGNAREGQIEEALKSGMDDVVIKPYKLPQLLRTMEQAVMGQSLGDLRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK90</accession>
    <name>K1VK90_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK90"/>
    <dbReference type="HOGENOM" id="CLU_1817155_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK90"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16395" checksum="77F332FB34E05346" modified="2012-11-28" version="1">MTVVGPDVPPAVAQRIETFYRVSDYDTHDEYMGCFTPDAKFNIVAPRHGHKQILEGRIWGMTTRTNQVHRLSHIWKTEDNTYLALGDIDFDRTADGAKVRDLPFVARFRMTQGEDPKIDVYYVWVRFPPMLTGENPYALDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK94</accession>
    <name>K1VK94_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK94"/>
    <dbReference type="STRING" id="1220162.K1VK94"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_9_3_1"/>
    <dbReference type="InParanoid" id="K1VK94"/>
    <dbReference type="OMA" id="ETRAGCS"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="64"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="567" mass="62157" checksum="CDE990D472A8EFE3" modified="2012-11-28" version="1">MFSRSRKEKSESPLIASIRESTIGHRTRIDGTHYQVPLLHADSTASGTTLLGLEEMLVLGVMPTYANTHSEASWTAQQTTRFREDARAWIKQSVGAGEGTSLIFCGSGTTAAVDKLIGMIGLRIPTQLDARYGFDSQIPPHHRPVVFVGPYEHHSNDLPWRATIADVVLIPEDARGNIDAAELERQLVLYADRPLKIGSFSAASNVTGIISDMPALTALLKAHGAYSCWDCAAAAPHLPVTLGDADALFISPHKLPGGAGTPGVLIVRDAFVRRADLAGVRPAVPGGGTVDFVGPDVVDYTSSLEHREEGGTPAIIESIRAGLAFRLRDAVGAATIQRREWNFVQRALAAWRQVPQIHILRDTGAERVSTVSFTLAYTRGQLVHHNFVVALLNDLFGIQARSGCSCTGPYGHLLFSYTKAQSEAIRHPILQGYEGIKPGWVRISFNYLHSDEEVDYIIAAVRLIATLGHNLLPDYRFNPEAGSWVCAAAPRRPLGLEDVWLRFGGQTRLQTGAKLKAKLAQSYMKRPLQSYLDKAERVMQRAAERRDKPFYPQGKVPNVTDECPRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKL1</accession>
    <name>K1VKL1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000192">
        <property type="protein sequence ID" value="EKD04685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKL1"/>
    <dbReference type="FunCoup" id="K1VKL1">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040265_1_0_1"/>
    <dbReference type="InParanoid" id="K1VKL1"/>
    <dbReference type="OMA" id="THIRACI"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="4">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="3">
        <location>
            <begin position="199"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="372" mass="39805" checksum="91286F5342BAFB9E" modified="2012-11-28" version="1">MSETTERKSRWDAPAPGNAGGDAAPVPAPAGGESKPSAADNEAAQKAAAIAAKIAASLRPPGSSGFEVARRAGAPEGDFVKDIEINDLRNRYVLTRSSTQKNDETGASIETKGVWVPDRSRMPPGEMPLYLHIVAKSQVILDAAVAKVNELIDQELGPLIEERTLIARARATGQPLPPGVGQRQKWPEEKLFIGLDPIRNFNIRAKVVGPGGMFVKYIQAETGARVQIKGRGSGFIENDTGRESDEAMHISIVAPTDEQIQRAKILADDLLMVLRIEYDKARGVYPASGAGYDSYGGAAVQGAHGYDTAAAAQQANQDASTAPYYPPAEGPGTEQWEAYAAYWRAYGYDVNDPQFQEWQRGQMAAAGQQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKN2</accession>
    <name>K1VKN2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_04399</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKN2"/>
    <dbReference type="FunCoup" id="K1VKN2">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKN2"/>
    <dbReference type="eggNOG" id="KOG0343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="InParanoid" id="K1VKN2"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="91"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="284"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="509"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="779"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="549"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD01321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="842" mass="93615" checksum="CC0CA232E3862E08" modified="2012-11-28" version="1">MAPQGESSRQNGAKGKGKDKGKGGGKPLVKTNKAKRERIDAELRELQAKIDNYVAPSEITEFKQLPLSQPTLRGLKKAHFVNPTPIQALSIPPALKGQDIMGSARTGSGKTLAFLIPILERLFIHKWGQMDGLGAVVISPTRELAMQTFNALCSIGMYHNFSAGLVIGGKPLKEERDRLSRMNILIATPGRLLQHLDSTVGFESAGLKMLVLDEADRLLDMGFLPALRAIVKHFSPGGHNASRQTLLFSATQSKDLATLAKLSLHDPLYINTNKPGEEGVMPSNLEQFYTVVPLERKLDALWGFIKTHLKMKGVVFVTSGKQVRFIFETFRRLHPGLPLMHLHGKQKQPTRMEIFAKFSSSNSALLICTDIAARGLDFPAVDWVVQLDCPDDVDSYIHRVGRTARYQSEGKGLCILLPSEEEGMLARWAEKGIEVKKIKIKESKMGNLEQQMQNFAFKEPEIKYLGQRAFISYMRSVHIQKDKSIFKLSELPAEAYAASMGLPGAPQIKLLEGGAGAGRKNRSRGSQKKEEEEEKDDGPIVIHQKLASDSEESEGDDEDESEEEEESEDEAEDEEGSGSESGSEEESGSESDDSSRPVRTAPVRTKYDKMFERKNQTLLSEHYNKMVEHEDDSDDDVFTLARVNHDLSGGEESDAEEAAGPSEPLISSEDLSKRKLKAASTKKGVLKSRPAPTKLVFEDDGTARDFYKAGARAEEEAGGEEARRKFFEQEKERMKEADVIDRQVAREKRRELKRKRKERERELRKCVSANTQAMREYMDDAGEFSDEDGAPMAYIGSPSRSPSRSPSPEPERRTKKSKSSKPAPAADIEDEEALALRLLQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM91</accession>
    <name>K1VM91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM91"/>
    <dbReference type="HOGENOM" id="CLU_1129766_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM91"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="27671" checksum="68E0FF58F8B45A5D" modified="2012-11-28" version="1">MVPPCLSFPTLTFSGIGAPTVEEFIASLEGQLSASDAPLLPGQISGRLTGRALMWYTETIRCHHFRLTEDGYRHLRSQLLGEFSLRERNPQRIFRTLTQGYLSVEEYATEWRTLAGHLGEDVESYLNRTWWAYGLRSELRDIALAAMHIPSFGELAAEVHRAEWLLCPRTSQRCREVQQACPCSEGESDWDEDSTWEMETTGSTEETKVAEDIQRTNGDTAGLGGSTEAELVKLFGELLRARLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VME2</accession>
    <name>K1VME2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VME2"/>
    <dbReference type="FunCoup" id="K1VME2">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VME2"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142408_2_0_1"/>
    <dbReference type="InParanoid" id="K1VME2"/>
    <dbReference type="OMA" id="NCARSWV"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="100" mass="11021" checksum="2F2375B4998A3783" modified="2012-11-28" version="1">MGWFGGSSQKEGIEPGQAPTRAQRKLCWENRDAYFACLDQNGIMQADDGELGDKAGVCKDFRKAYEGACGKSWRRVLEIRSQKTLEAAAAQRGEAAPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMK5</accession>
    <name>K1VMK5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMK5"/>
    <dbReference type="STRING" id="1220162.K1VMK5"/>
    <dbReference type="eggNOG" id="KOG1679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="InParanoid" id="K1VMK5"/>
    <dbReference type="OMA" id="WRSVAFS"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28564" checksum="F95389A394A6D599" modified="2012-11-28" version="1">MRPCLRPGRPLRALQAARSYSVASKPHAYLTPASKLLNRDLPGVSAIVLDRPEARNALSMQMVDELLEIMAKLPNDGTRVTMVHANGPVFCAGADLRERKTMSRERVDKFLNDMNQMMRDLEKLPMPTIAAVQGPAMGGGTELSLCCDLRTGQPETTFALPEVKLGIIPGAGGTQRLTHLLGRSKAMELIFTGRKVDVNEALELAPLSLRAAKQAINAAPGTPIDEGLRLERAAYATLLDSEDRLEGLRAFAEKRKPIFQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMR4</accession>
    <name>K1VMR4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000337">
        <property type="protein sequence ID" value="EKD00642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMR4"/>
    <dbReference type="STRING" id="1220162.K1VMR4"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573887_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMR4"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="2"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="476" mass="52714" checksum="B2AC55D532CC8A84" modified="2012-11-28" version="1">MAQMRHFPELWHFSAAHYLSAGKEEEGKAFLQAGVAACPKSFLLSFALAEMEEDQRNYAECHTIFTNLIERLNVEIDELKLTVSKEVEIARGPEIPAAAHELNNEESDYARLVRERDERGRLVQERRGRDIDDAKAALGIVWVMYMRFARRAEGLKAARLVFGKARKSPHVTWHSFEASALMEYHSNKDSAVAVRIFELGLKQFDEDVPFVIKYLEFLLAINDDTNARALFERSALKIPADKARPLWDVWARYEYMYGDLVAVHKLEQRWAEAFPADSPLKRFAQRFSFDGIDEIALRDLGFGRQRHTSAGGFGGGGHGGHGGMAGPAPPPALPPAGVGMLQQQAGFQPRSPQKRPLSPLPAGSPGRDKRARPASPVPPARGMQRFGSNDNRPPAMPPMPPRAPPRAAPTPAVHRSGLPNQLAWFIGQLPPTRSFDGPVFRPDDIIGLFSNIAANGTGNRPVPPARGPPAGYGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMW7</accession>
    <name>K1VMW7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMW7"/>
    <dbReference type="HOGENOM" id="CLU_444952_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMW7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="614" mass="66553" checksum="BBCA01CC2359ABCC" modified="2012-11-28" version="1">MILFRHGRLKPGGYEGCVTGLRSTSPGGGQSRCYISLDALGKGVSTRMYDFIRQNPGTLAIYLNTRINVRDVTQRSALVQAARTATQYISEVSPALSFLALLITTDKESVGHEWLGSFASDSPLSSDAAHLQWWPTTAYKGHNAQTPAKQAVRGISPLSLADRLKNARLAAKAKGYEHKCRARHRAHLDAAEKALKSGLLPAQLTDRQRRALARRANDVAREKKRSAERLDDRHDLKRAKAAGVLKEEFNERQRKTQKRLDNDKAKRDEKYRIAKEAEEAEAAGLPLTELQQKHLTSVRSARLVESDQEDIVFLGHGRNSEPITIFDSEDDIAGSSAKRYSGSFHAAAGPDSKPYLPSSTIGSSRTRHARAAASTSTAAVPMSLTTSLQAASAPDTSRRIYLAPQASNADASLDDSYQEDDTEPERSFDMKRKIDSLGYGKDTIRAFPKKVDYDEPIAISNDDDDEIMKPTPVSRSASSSASGPSKTKKPQTNPKNKDLSVTKEHEASTSASSSRGTASSAYAASASASSSRGTTSSALSSLLPYLVKDEPSRSWTTSSGGSTAQAASASLRSEDEHNNPEQDDSDDEGDEQSAVLGSPDDDDDEFDDEEEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN43</accession>
    <name>K1VN43_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN43"/>
    <dbReference type="STRING" id="1220162.K1VN43"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="K1VN43"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="503" mass="55849" checksum="4A4D55D98587A486" modified="2012-11-28" version="1">MSGVQADQRVSVESKPYEDRKEMLDDDVDRHYAVEIPQILKDVGPEEQGRIDRRVTRKIDMLLMPPLVILFILNFLDRNNVSTAKVGGMTEDLRMSGQEFSTVVAVLFAGYISLQVPSNMIASRVKWPSFYICCMTAAWGTVSACTGAVNNYHGLLVCRLILGFTEAAFFPGALFLLSLFYTKRQIAFRTAILYSGSQLGNAFGGLFAMACLQLDGTHKLEGWRWLFIIEGAMTVGFSLIFATFIPNRPETCRWFTDAERAQAVYRLQLDRATKDASSEMSIGTATKLVFTDPKVYLIMIALTVNFIASAVTNFFPVVIREMDPDYSKIQSLGMTAPPYVLCVITIWIMGYWSDRIQRRTIFVVISMAFNVLANIIAVATTNVGARYFAMMLMPASFYTSSTIILSWMSSTIVGPDIKKATAFALINAVANTSNIWTSYLYFGAPRYVVAFGVNLGASVVVILLILVLAGYLSRLNKKLDNGQSLGKNGPTDVQIEGGFRFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNM0</accession>
    <name>K1VNM0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNM0"/>
    <dbReference type="FunCoup" id="K1VNM0">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNM0"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046346_0_1_1"/>
    <dbReference type="InParanoid" id="K1VNM0"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="26701" checksum="9D2209B26CA5140B" modified="2012-11-28" version="1">MKLNVANPATGAQKSFEIEDERKARIFYDLRMSQEVAADNLGDEWKGYVLRITGGNDKQGFPMKQGVLLNHRTRLLLSDGHSCYRPRRSGERKRKSVRGCIVGSDIQALSVVVVKQGENDIPGLTDVVVPKRLGPKRATRIRRFFNLSKEDDVRQYVVRREVTTKAGKTYTKAPKIQRLVTPQRLQRKRHLRSLKKRRAEAQKEVKAEYDQALAKFHAEKSASKAAHKAAHSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNU1</accession>
    <name>K1VNU1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNU1"/>
    <dbReference type="HOGENOM" id="CLU_1571731_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNU1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851991" evidence="2">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="170" mass="16218" checksum="0529276214BF6E2E" modified="2012-11-28" version="1">MHVSLALLALPFASALSALPGVTFSPPPEDNSVSASTTASPPTSSSTPTSEPGSLTGSSYMLTSAAPPTSSNIPTSASQPTSLASAPTSNPQPSSSSSFSSVSPQFGSASSNESASPGTSATPSPTSSPGRTAAASSGPSSDSASDNSAATNIQAGLALAVGAAALCLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP30</accession>
    <name>K1VP30_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Plasma membrane zinc ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP30"/>
    <dbReference type="STRING" id="1220162.K1VP30"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="InParanoid" id="K1VP30"/>
    <dbReference type="OMA" id="DSNCTCE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF55">
        <property type="entry name" value="MEMBRANE ZINC ION TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="323" mass="34761" checksum="05B8F47BE182EA60" modified="2012-11-28" version="1">MSGGLYKRDACSGQVKSTDYNLGLHVAALFIILGVSGGACALPLFVSRFPIRGFFFTVRHFGTGVLLATAFVHLLPTAFLSLSNPCLPKFWTEDYPAMPGAIALAGVLVVTVLEMILSPSRHFVPQRRPRGRLASVSENEVQLDALRSDLAATDVTLTTTETEVKVVLTPEQERKKSMLQVFMLEIGILFHSVFIGMALSVATGGDFVVLLIAIAFHPIDWPARSPRPYLMVLAYGCTTPIGQAIGIGTHTLYDPDSVFGLLLVGIMNAISSGLLIYASLIELLAEDFLTDHSWAVLRGRKRVVAVALVFAGALAMSVVGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQB0</accession>
    <name>K1VQB0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQB0"/>
    <dbReference type="STRING" id="1220162.K1VQB0"/>
    <dbReference type="eggNOG" id="KOG0309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258996_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQB0"/>
    <dbReference type="OMA" id="YPYGPEI"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="748"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="788"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1263" mass="138701" checksum="C8E88B1016B8263B" modified="2012-11-28" version="1">MATVSMDAGIRGWDLRVQGSTPIIRLSAWGAAGTQVKWNRKAEHILATAHGTRVLVWDDRYGSVPVATIQAHDSKIYGIDWDRRLRHRLVTCSLDKTIKFWDIPSVVSEDDRSTLASEDFSAGEPFTNATIQTGYPVWRARNLPWGHGVLALPQRGETALEMFGTDGSNVPIERWEGSSGVVKEFVWRRRGGADPDFEDRNFQLITWSLDRKLRIWPMPKDLLERAGYKPGAPIDVDVTRRGAIDRTFSVPLDPLGQALKPLGPEKPTIPSGIARQRMLQRPALTSMTRGGKSTRKIGQIEWLSRIVKTGPGAAAVASDSSAGPSRAPSVAGRDSTNGSSSRSRSKGPHGGRTESLRHMSQTRGLSLTRASSVNTGVGTESVSDLIPLKDEVLSVHKMFPKSKVNFEKFDLSQRKLTMSLNGPWANGDRYAFIRVHWSFPPNYPYGPEIPTFELERNATVSPITRHRMISTIKEMRAANRQCLISVTEFLLGYHERTSRRVVDEDSDSDTGVDEAANVPMLIRTTGAAFGPNGQLVCFFPKQTVLPRARSGHSRSPSREDPMSTPLAKALSALSRLENPHNKPTMVRYKRHVRTMQAQLQPMQSRSTLSLYNVSHLVPEPDPELARLYTASIDGNLVHALEVKKLEHAEVWAALRALLTDPPPPYSDHAPLSRTAATHAERFRWEREMERKRCVVDGIFDRLMERMDMQMLALVSCCLLEYEQSAPPPPAIEEVAQPEPSYFGMRKVSRASAGSGGTSGTAVTPFGPGRRSSSLTPSTPVSATGPGSLRTSGWSQILMNPSSISLRGMALTPRDRTSFDQERTPGSYEERSPVAIPGTPSRHDHPFTRHESHSSITGLPGLPSPRRRATRPFARSGSMALASPPLPPVPPTPTGRSVDERAATASASSVPESSNLATSAPRTGTKVSFGSASPLRRVFSKPNLAQTPGKLERRRMTCGVHLEFSSDAPPPSLLRSELLPLAELWKLAYADWLLRAGLVGKRAALLQYEFASSPPPKVYREGLVYATRCRACDSAFVPQGEEKCTSCSVPRQAPLCSVCNTTVRGLSASCTLCQHTSHWRCLRATLELLKHCPACSCQCADGGLSANFSQTRPEGPTRQVLVEDPRTQASKRFERSSRFVDLTGGDSRPASRSRERKRDAGSFGSVGSGYSAAGGYAQGGFSSFGGELGLKLTPSHTDEEEYHSQSIAALQSVEQRDAEREREGRDREREREREMSPPPREAAREGMLARARARALGPEGILPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQE3</accession>
    <name>K1VQE3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQE3"/>
    <dbReference type="HOGENOM" id="CLU_934425_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQE3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="298" mass="31757" checksum="8B921E4501A48790" modified="2012-11-28" version="1">MAAHITVDHTSTTCRRDVGGGVPCGEVYDTFGELKAHLELDHGLLRFEGGKSHQVRYCECCEDYAVGLPAIRMHAAKHISDTLALMSVDPTCLGYQGALVQLFLCPLCIVDAELPPEKQFNTHSSADTRTKHMCSEILTLHPHTPVECPFGTCSGETFAPAELCDHIIVKHEIKIAGGTGKNKKKINGDFSKLSMAPDTRKKFDRSDFRITPTHCATTRPGSDESDAPSDHQPSQTAIQRGQSLGRGRARGGRGSAAASGSRGSSSATPTAGRGRGRPRGPGRGRQGGRARGSRSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR22</accession>
    <name>K1VR22_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR22"/>
    <dbReference type="HOGENOM" id="CLU_934426_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR22"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="28577" checksum="1E8404B7CA0764F5" modified="2012-11-28" version="1">MPLFNGRKWSDYPAYPYRHDFVHKPAPAATAPQAVGLDQRILYVPGGKKLLRNKLFFTAFIHYEEDDDVRRVCTREDLCAAFERLVSIFQELHNAGRMLDELPKLEPQLAVRLTALKQKLAEARLRALWAAELFGQYLSFLSDCEDAGRLPKDRWRPFPSDPDETHTTQQTMEVIDGQIDDYAFRVAAAVNRRKHKGQPAYVVELKAQIDALLNDILRSTGADAPRPKSNKHIKYGALPAGKTANRSATIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR66</accession>
    <name>K1VR66_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuole protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR66"/>
    <dbReference type="STRING" id="1220162.K1VR66"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794979_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR66"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="349" mass="38617" checksum="50DE867C69D8034C" modified="2012-11-28" version="1">MSVFERIDGVPRLVHSLPVIADPRVTVFHVLLGLSVLSYIAVVAHRPLAPDLSLAPPDARPLPGYEEWDEAHEASPPENPVLEGVPPPASLAPVARPAPIPEPDDDDIPLRLLRNSPSRDPEPAAPEETDALLDGFDGPIAIMAKSNTGGPRQAALEAYRFFQDPSRYDGGSYPENDMEALQLTFTPVLFLLLAIIGGSLALALGGLAGYHWYLMIGSRQRLPGAWRPDHILTRPERTRLRREAREINVYDLGWARNVRQVMVGDATLPAASWGEWARDVARAAWPLTPPRMQKYARGHVFAHDRDALRDLKALTREVRLGLGAEAERRDSDTTVSADSDRVPPYRRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRH2</accession>
    <name>K1VRH2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRH2"/>
    <dbReference type="HOGENOM" id="CLU_1143239_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRH2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="243" mass="27601" checksum="F37B45BD63D1FE28" modified="2012-11-28" version="1">MSTSEDGPRSPNRLTHGAGSPSCDSIDEAGNHCSWHVCGSEECPEPGKAWRDRGISGGNGETLWDRLASRRYVDERIWAYVDHDWVPSSSRPLLVLGADDETCQRGCAMVHVKWDGEVTSRTPGDVRLLTDVKADTPLTALAPAIGSFSFKSVPGLQEWTEYNEGDDSMTWGQYCFHRISYDKCGRDVIEFKKKLGDNLVQCAGEKWEILSRDRRWTWLRDAHDRRDRLRQCKTPRKPDENAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRJ2</accession>
    <name>K1VRJ2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_03599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRJ2"/>
    <dbReference type="STRING" id="1220162.K1VRJ2"/>
    <dbReference type="eggNOG" id="KOG0608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010437_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRJ2"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05573">
        <property type="entry name" value="STKc_ROCK_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="388"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="717"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1021"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116194" checksum="64CA430412C1DBD0" modified="2012-11-28" version="1">MAARLRHAGQTDRSREEGDSQAGAGAGGRGQSEPAGRVSPTAFTSALESVKRLEPGSPYVRVRSHSLAPHSRPRPISQSSPQSNRNSAPPTSAWWTPGLHALTADDSMLRIAETTKIRPQVDSSHLLTPPPSSAPLPSGTVSAPVTPTKTDLRSFGAGGFVPGTGGYAARDALGAAAKEGGGGGAGPCPVHGYSVGRRPRQSLPPLPPLSSRVGPGPKGTMSPMSPLSPTPGANMQQLQAQKMLGLRVDLAPMRPHSPIPPTSPTTPTMPTKPVTPTTPTGRAYALNEAPDSPASVSTAATGERRPRVLNQMPIERGSVSYTDNTATTAAPRPMLRPSLETLERAAAYVLHMEQYYESLTNGVWALGVGGAEGGLRRERNHNVDIKSFQLGRVIGQGAFGVVRIATERAKNRIVAIKQLRKSDLLKMGQEGHVRAEKDVLAAASSYESTWIPRLFYTFQDHDHLFLVLEFMGGGDLLSLLISRGRLPEAMVKFYAAEMVLALHQCHALGYIHRDVKPDNFLFNKEGHLRIADFGLATDLHWSHDSSYYETQRRQMLKRFDYPVGRAAFGNRRRSRQQLGIGPQAISDANRRFQRRRRQLAYTICGTNSYMAPEVIMGTGYGFGADWWGLGVIVYEAIYGSVPFSGENRHVARQKILDWRSSLVFPREPRVSPLAIDFMRQLMCGAEDRLGYCRKPGPDEGPLGNDGAAALMAHPWFADIDFATITEQVPPFRPELSSVDDTKHFDADIPDEPLAPANSGVEIKDPLLGNEGEGKHLLEVRKTLAFKQWTFRSPCAQEWRFGHASRVSRANSGASATSRVRSVSAAGTIGTIPRSLAAATPLDPHLEADSSSIDIDLDFDRCSASTSFHASVINGAGLTVLPLAEQMAQAELPKYHVRTNRYEERISATSSEDDDLDAHVEWEEMFLKKKARHIHNDLRALSVRISSLNSSFDGNPADRKPPLRPVTPAHINVLEEEHFSDEPEPLPYDIASSSEGGDHKFQPHARAYAELVGDNSDRTDMTETAATESSQWTTTDDIHDLTNEKKQLRHSKPVESLRAHVKQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRT4</accession>
    <name>K1VRT4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRT4"/>
    <dbReference type="HOGENOM" id="CLU_2428626_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRT4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="91" mass="10218" checksum="A7BB24E874E73B32" modified="2012-11-28" version="1">MPTLDAACYPHIFEAVFAFAVADGDVRIMSRLRGVCREVRDHIDRIWYHAIVDDKGIHDLGVFRDRPVARVSLPAGAAYPALLDIRLTGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRW7</accession>
    <name>K1VRW7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000295">
        <property type="protein sequence ID" value="EKD02232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRW7"/>
    <dbReference type="STRING" id="1220162.K1VRW7"/>
    <dbReference type="eggNOG" id="ENOG502REVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877688_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRW7"/>
    <dbReference type="OMA" id="WAWDWPE"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="35060" checksum="38760EA222BB6617" modified="2012-11-28" version="1">MPTVRFVKYELDNFHNSTGYYLRHAYAVVSAYLAEFRVGEDAATTEKREEATVEALVALDAEQESTLLSQVQRRASKTQGVALLTLYGRGLAPPPSFFNSPPSASLTHVSEAKEEAKKSLISSFKLRVRRGKSHGHLSLCFGVLCALLEISPATAHHVYLFTHLRSILSAGVRLNLIGPYLSTQILSWDGRRIIDDTHDVRRPWDCAAPVDPVDAAFSAVQNPISSEKQAKGVPNGEDKLDDAKPAQAELDGDKKPTQAELAAAEEKEVQMKEEAKKQPEDIWAWAKTCEAGPCTTWPLIEILTSRHDLQHSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS91</accession>
    <name>K1VS91_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS91"/>
    <dbReference type="FunCoup" id="K1VS91">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS91"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_1_0_1"/>
    <dbReference type="InParanoid" id="K1VS91"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="657"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="765"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="573"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="921" mass="100163" checksum="52E0EA13C623180D" modified="2012-11-28" version="1">MADAEVEGVPPLLAAGVPMLKVSSKKIKPVTVRLTDTAITWPSLKGGRASTDSTVANKAVDITSIRELRLGQSPTDTYDSKRWLTIVYVRGSVWKVMHLIAHTDDVYDLWVSALQGLVSQSSDKVVSGAAHGPATDPDLLFIRQLWPAGQKTLNEAAAKGLCGKLGLDLTPEALKRYQFPIDSATFRQLVRDLQTRPDLDDIYAQLARDGPLNKARVIRFLTQIQRVPESEAETIFERYAEYPPEQLGVQESKELLAAPAPRAVKVPAVPPAQAEVKVEAKGDNDSIPQEKDTGNGSAQHDQEEKKPVVGLSVEGVPVNESEGSTTPQTPNSARVHDAVQAEHVLRTSNVGWNDTASASPTSTVAGWWTAPSSPYPVSPSGTLSPSGTAVPPFPVSPMSTTPSLPRGDRGVWGADAVKLFLSSPDNVYFPAAAQDLSKPLTDYFISSSHNTYLVAEQWRGASTVEGYVRVLLGGCRCVEIDCHDGNSEPIVYHAKTITSSVGVRDVCQAIKKYAFVASPYPLILSLEVRCNLEQQDKLAQILVEELGDLLVTEPLDNVDGMPSPEQLKGRILVKAKGPPSGGSNPSSMLVPIQSSGSTSSGGTGAASLSPPVLSSSPPTMDRTDTDSTTESDSSILRLARKLSINTPKAPGQFSKKLVDLAVYTQGTKYRGFSKLVHYASNQMFSVSERTSNKILASGQASDWVKHNTSHLSRVYPKGSRLSSSNYNPIPYWEAGAQMVSLNYQTLDQGTILNHALFAPGGYVLKPPCLRYPKIYEREEKITVKLTIISAQRLPPTPDLYVEATLLGPDDYEESAKTRRIHEPTLNPRWDSSLSFTIVTKPSLLALSFLHLEIKQSGNGLVAQWIRPLADCGRGWRYLPLEDATRSKFLFASLFVRLDIENDQQVPLLRLPSPPEPKSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS93</accession>
    <name>K1VS93_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000285">
        <property type="protein sequence ID" value="EKD02427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS93"/>
    <dbReference type="HOGENOM" id="CLU_1636611_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS93"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="162" mass="17086" checksum="67E93C74AAC7C461" modified="2012-11-28" version="1">MTEPGAKPQSSTDDLKQINEGPQCGSNLTRQGLRPCDDTHLRAFDHASPGKEDFSPPSPLAMSTVGRPNTLHADGLKRAGLEEGAAVRNGVGLPGPASKATIIEVQHHPFRPAAPVCAPTGFQVLLGPQLVTSEETQHDSRMVESSIVLRKAVPRAATTAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSF1</accession>
    <name>K1VSF1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_06123</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSF1"/>
    <dbReference type="STRING" id="1220162.K1VSF1"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="InParanoid" id="K1VSF1"/>
    <dbReference type="OMA" id="MRLGCNQ"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="46"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="231"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC99587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="340" mass="36598" checksum="274E8458D3C9E928" modified="2012-11-28" version="1">MLAARSVLRTQAQLASAARVNTVARALSTSSVAYDAKQRADSMQRVTVFGAGLMGAGIAQVSAQAGLKVTLTDVTDKALENGINIIKKSVARVAKKQQPDDIEGFTNKVLQNISTSTDAGAAVADTDLVVEAILENLKVKQDLFAFLDTKAKKDTIFASNTSSLSIGEIALKCSEERQTQFAGLHFFNPVPAMKLVEVVRTPKTSQEVFDTLLELSVRLGKVPVKCKDMPGFIVNRLLVPYLLEAVRMVERGDATPEDIDIAMKLGAGYPMGPFELLDFIGLDTTQFIAQGWITKAEEGLVPLDLIKPTDLMAKLVEQGKLGRKSGAGFYDYSSGKPNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSS4</accession>
    <name>K1VSS4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSS4"/>
    <dbReference type="FunCoup" id="K1VSS4">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSS4"/>
    <dbReference type="eggNOG" id="KOG0378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="InParanoid" id="K1VSS4"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="262" mass="29476" checksum="FC35ED8C354C2603" modified="2012-11-28" version="1">MGRGPKKHLKRLAAPSSWMLDKLGGTYAPRPSPGPHKLRESLPLTVFLRNRMKYALTGKEVTAIVKQRLIQVDGKVRTDETFPAGFMDVISIEKSGEHFRLLYDVKGRFTIHRITPEEATFKLCKVKKCQLGAKGVPYVVTHDGRTIRYPDPNIKVNDTIKFDFQQNKITGHLKFEPGNVVMITGGRNMGRSGVIVHKERHLGGFDIVHVRDVLDRTFATRIGNVFVIGEGAKAQVSLPKGKGVKLTITEERDQKRRQKQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT09</accession>
    <name>K1VT09_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT09"/>
    <dbReference type="STRING" id="1220162.K1VT09"/>
    <dbReference type="HOGENOM" id="CLU_492737_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT09"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="553" mass="59268" checksum="59587FEECD9EC712" modified="2012-11-28" version="1">MTTVVQPSPAGFGSSHGHVPTHSHSQYPQQQQLQNSQQSQPAKHPRPPLPQPPQPPQHAQSPSQPPHPYGSQHGTQQFVPYTTPQTSASNLATITESAPPSAGTTPRTAAQASFPDLTPAPSHAPSAAASTEELAALEFAHETGTPATGLYSQNGLWSDDSDEEEQRMSWRQRLSNSTAGDRRSVKSSKSNGGHSHRGSRSKMDSIISPLSVESPWPWSRKSVAERRESPPANEQQEVLAGDNPVRGGSGNRHSGRMSPSTSISSCPQPHPGKHQHTASMHSISSQHSTVSAASVASNDLSLKQRISMGRLRRKSTSKGGFNDFPDVVPAVPQIPAALESTLSIRSQKTNSRGSLPGTAGDGKKDLKASASTKADHVNVSVIPTSSSSSSLKALAAEARVHAASPSAHSPRPSASSITTPRQQPQPLPSPSPTPTRTMPQPVPMPTPTPTQAVPVPRVPPQAQAPASNRLSITTQPKKEEKDRPKSYHDLNISSLFLYAQCCLRFVYPSLFSTNRYAVFSFLRLHPACSDFRLSVFSVQCRLTFVSARWAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTC3</accession>
    <name>K1VTC3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTC3"/>
    <dbReference type="STRING" id="1220162.K1VTC3"/>
    <dbReference type="eggNOG" id="KOG3382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110455_1_1_1"/>
    <dbReference type="InParanoid" id="K1VTC3"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="168" mass="19441" checksum="1C265BE2FD6AE5C2" modified="2012-11-28" version="1">MLKLTDRTIGDEKLGTKECLREGCRDYLRASIYASERAFWNSSQESLEVGVGERGSAGTGAESFGEDEFGNRYYENYNPREEQPGRQRWVDLVQYDFNATQIPRPWASWLTQIRLDPPTKDEVVLKSQQPWQVKWNETLTGTRGRFITYNTARPKVTAWEPQVKARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV59</accession>
    <name>K1VV59_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV59"/>
    <dbReference type="eggNOG" id="ENOG502S7TE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909175_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV59"/>
    <dbReference type="OMA" id="IFKEWET"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="28890" checksum="4CD79791C8348D41" modified="2012-11-28" version="1">MSISLPNGTLLAAPSSSQPPISAAVTRILHLANFSPELKTRDIQNIFKEWETEKGGFRIKWRDDVNAMVVFVDANVAKRAYLSLILNPPPSMPSPATIRPYDGPDAAQIIQSLAARAMGHRASMSSAMPSGSISGMMRDDGRGPNSGGINSFKMPLNPAFSFGGSASSGQGRNGHAQRMSYSHHRANSASSNWNRQSLSGALGFAGPSLGATRLPTHSEGSSGDISRTASMSGNEEPYRQRAHGGKGRRESVSAEKALREVELALQSVETKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV89</accession>
    <name>K1VV89_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV89"/>
    <dbReference type="HOGENOM" id="CLU_2098541_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV89"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852125" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="116" mass="12517" checksum="8C88CA1083CD1884" modified="2012-11-28" version="1">MLANTLLPLLAAAATAQAAPPAVPPVPDTVQTYKHLDNNGSGVSGYNVTSSWSYNYTWSSDGKGPVKTETSGGSNVDVQTIGELTKNLTEQLKSIPSYYYYYGSTCISRSYYNDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVT4</accession>
    <name>K1VVT4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2OG-Fe(II) oxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVT4"/>
    <dbReference type="STRING" id="1220162.K1VVT4"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="InParanoid" id="K1VVT4"/>
    <dbReference type="OMA" id="GEWKYVP"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="196"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="323" mass="37330" checksum="C81E6354F86F384F" modified="2012-11-28" version="1">MPVAVPTQLPQWTRPQKTKVDLPWADIKTLDFAKYDQPGGEEALARELDEAIRDTGFFSLVNTGFEPDEVQRQYDIGQSFFDLPSEEKDKEQYAVDFSNGNYFGYKRPNEKTVRGTQVRDNVETLNIPKFIKSNEHEPFHPHLEPFRDEIEAFSRVFRLFAIILELPEDYFSSRHEYEDPAEDHLRYMLYHPRSLADDESVERTWARAHTDFGSLTLLWSQNIAGLQVKTGSGEWRYVPPVDNGIICNVGDTLSFWSEGYLQSTIHRVTRPPEDQAHLKRQGLFYFVRPGNHVDITPADSPLLKRLGLLKERKSSRPVTGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW09</accession>
    <name>K1VW09_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000244">
        <property type="protein sequence ID" value="EKD03627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW09"/>
    <dbReference type="HOGENOM" id="CLU_1070342_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW09"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="260" mass="29062" checksum="4F4CC017A962B652" modified="2012-11-28" version="1">MDNAVHYSYHPYGYMPGAWFPTLNPAEYSIVYDPTAGAYFYVSGQPYANGVVSGPPYPHSEGTDNEQVVPASATSVPQPGTPYEVPASWQLYTLAHVRDILRAAERWRHPHVRIILSSLAHSWSAQLNAVHVVVIPPGSSKQWLVLIFNRQSGLVFHGSETNHALRRAYNVMSTKAVPFSAIKLPCLSGKNGGVFATALAVWVSRNWRHNYEWDFVIDEKQARKEHQDILRGLWPDIRSVSIRRKAQLASALKAEGFLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW47</accession>
    <name>K1VW47_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW47"/>
    <dbReference type="HOGENOM" id="CLU_652449_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW47"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="481" mass="54896" checksum="C86C4AFF62AAAE54" modified="2012-11-28" version="1">MRSHLTYLPPEVLSTVFSYLRPRALRQCLLVNSAFNTLVRPHLFRYIAAFGDEAEPCFFLLHDNSFLEALAVIGDIDEDQPIPKDLSYMCLFAHAHCCNREREPFSSPTGSPFISSCRVLNVHLALPDDEDNISSAHADYFNPGWRLVDRPLEGPYLQPLQCHILHHALEDARVDKLVLRNVPVIYGNVDPDLLPPSAAETVKEAVLVLNVDSMNEANRSLVEDYLAESFDCFEEEHDGIESVRPCMEPGELERPEIGSLASAVPPNVEDLTLVFWTPRPRTDATPTCCMPVPLCEECETKDSEDTSDAEKQPSCWQEKFWNDLADTVAPRLIHQLGAVTIVNASAIVPAGAVREQYVRPISTGVATHTTFEKKYCNILSSRLTGEYGVQSGRVKEYVDRVHFEYMSDWLLSTEWEDVFEWSEVKPWLQFKRPALITDYFKPVDPDTVKWRKDMNPTERISLRHKRSTMKRTKPNKYTWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWM3</accession>
    <name>K1VWM3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWM3"/>
    <dbReference type="STRING" id="1220162.K1VWM3"/>
    <dbReference type="eggNOG" id="ENOG502SBFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035170_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWM3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013266083" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="366" mass="38464" checksum="CF600CD674B58A0C" modified="2012-11-28" version="1">MKFLGVSILATAAFAAPLQARGTAGQVCDNPGRVVSLVLDSSSSTEDTDPNRLRIQGGLELLDYLTSASEATEKNKADTVSIVSFDQAAKLEYPQGDPNDVARAKLSAIDSVGMTKIYRGIRLGLDQILKSNPGNRGGLILFTDGQDTSLEEAVEQINRATAAGVRVSIGHTSVDEKQAAANQGGLSGIISEVGRWFSGPPKNGLVTPLDERISQAALASGGTVSVLTSQEAQKEFVQQVIKNGITNNDGKCSGNDIGESGGPLINNVHSLGLCSKNAEAVFTYSPKSQSEELTFEVNLHSKESTVNIDATFINKATGQTSTIAINKNNLFGELKGAATAGQECEKPVCMCKCDTPGAKPMPKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWQ9</accession>
    <name>K1VWQ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWQ9"/>
    <dbReference type="STRING" id="1220162.K1VWQ9"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="InParanoid" id="K1VWQ9"/>
    <dbReference type="OMA" id="KYFFIRT"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="61"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="474" mass="51050" checksum="9BC9B0DDC6498A8B" modified="2012-11-28" version="1">MPQWAKPEEKSLYYVSTAEAGDEKSAGAEIRDARVIEDAVFGQVGADGKGPNFRGVGLGGTFVLMTKANVGLGILQIPFVFQAIGIVPGIVLLIGMAILVAWCGSYIQPFKLNHPEVYGYGDIGQVLFGKWGREIFSIIFVINFIFVSASAMVAVSTALNAVSVHAACTAIFMVVAAIACWMLASIKTLGDITWLGWVGMVSILASVITLTVAVGVNDRPAEAPQTGPWDKDFKVAASTDAIGGIGAITNVLYAYAATPCYWGIISEMKDPRMHNRMMCISIAMCAALYIIIGSVVYWFCGQYVSSPALGSAGVLMKRVCYGLAIPALLVSCCIYLHLASKFIFIRILQGTEHISRPTKRHWITWFGCTIGAGGVAYILGSAIPTFDAIVGFIGSLLTPQTTILVFPLVWWHDNWRYRQRGDRSVPMMLLNLFIFIAGLFFVVGGMYAAVTNLINTAATNGPWTCADNSGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXI6</accession>
    <name>K1VXI6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000231">
        <property type="protein sequence ID" value="EKD04197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXI6"/>
    <dbReference type="FunCoup" id="K1VXI6">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXI6"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="InParanoid" id="K1VXI6"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor C C-terminal" evidence="8">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="37629" checksum="37F3A522A3C5EB68" modified="2012-11-28" version="1">MTQAATTSTTAKFADAEGYEMPWVEKYRPQYLSDIVGNTETVERLKVIAEDGNMPHIIISTTSIHCLAHALLGDAYREGVLELNASDERGIDVVRNKIKSFAQRKVTLPPGRHKMIILDEADSMTAGAQQALRRTMEIYSNTTRFALACNMSNKIIEPIQSRCAILRYSKLRDAEVLKRLKEICEAERVKYNDEGLAALIFTAEGDMRQAINNLQSTWSGFGFVSNDNVFKICDQPHPIILRNMILECSKGNVDTALETIHSLWDKGYSAVDIVVSIFRVVKGMDDLPEYTKLEFIREIGWTHMRVLEGVGTLTQLGAMIARLCKMAIPPEKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXP4</accession>
    <name>K1VXP4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000228">
        <property type="protein sequence ID" value="EKD04272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXP4"/>
    <dbReference type="HOGENOM" id="CLU_556895_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXP4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="490" mass="52696" checksum="786D2DEA53629F39" modified="2012-11-28" version="1">MPALTTQQPVKVHAKVKVSTTSGPYPGKLPVRTRTPEPAPRPRSVVRDILSKPEREPTMAELYPGPKPPQRTRDPVPPSQLNPKKVLKSQTEPDMKKLYPGPKLPERTRPPEPPRKRGSSVKSERQPSMRELYPGPKLPERTRDPVPPPPSSRGSVKKVMSILGRSSRNSSTTSVSTKQGQGKPRTRHGSDVWDDKANGYSNGYANGYANGYTNGNADDNTVNGHADGSTVNGHASENTANGHAKPEMQDRQVMTDAYLLTPIESGGLGGLGLDLFVHERDSRELREPPQLQQGREEQPSKLSAVGAQSVAGALSHLSLSAVRAPSLKRVPETSPVSTVSPLPARRSSLIAPRSPIMPKPAEDITVTLWTRDGAASPASVPCETDSESEPDEEPAVTIFPRGSSRLSRAPSVVISEHNYDFAAREPSVSARSRFSTASGYSTAMSGYSTALTGYSTAYEDLPSPGSADSGGYGNYNLYGAMPVTTSYNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY33</accession>
    <name>K1VY33_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_01213</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VY33"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="InParanoid" id="K1VY33"/>
    <dbReference type="OMA" id="PTMRGSE"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000014">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 13" id="KW-0518">Myosin</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1247"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1642"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1667"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1696"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="17">
        <location>
            <begin position="1"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="1007"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="13">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="856"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1772"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1796"/>
            <end position="1818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD04437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1835" mass="205131" checksum="DB6B3AC8826FB827" modified="2012-11-28" version="1">MASGGHGFVPSQAAQYADLTTLISSPSGDGESSAKVYPNEDTIAALLHARCRAELPYTRVSASGTDYVVVNPRRHLQCLNEESRKGYEEDITTTDGGVGNEPRQPSAYELAGRVWLLMSRRRDGLTASGKSTTLRHVTSQILSLASVTKAQKRTSDQISHLLTLLESFGNSKTPINPSASQHARYLELHFSLDGELAGAKVLPFGLNKYRIGHLEPEERTFHVFYQMLAGASPDEREELGLDDPDTYALLSSSNCYVLPAGPFSDDSTQLGELRAAFASLGFKAKHVRSIFSVLTAILVMSNITFHDEKQDGSLGMVSYEERTQVNERGLLYEVAGHLGVNPEELEAVLTNRTKWVSHDLASVFLDAENAALQRDSLMRDLYAILFAFVVEMANKKLAPGADTPPGLQIAQIDLPGHQSRTQETEVDPRRSTLLQQATLINASGNNGFDEFAYNFNNELLHSYLLRRAFDDQLNWNLDVTEDGIRLPPVIPHDNNASVELLRGGLLGSARLAKQPAGVIGAIAGVGEQIKGEDREDVKAKTVVGTLTTMFTGQPAFNPNPTGGLGMTPRQGRMFGISHYAGQVSYDATDFIDHNADVFDKQLVNLLRNSHDSFVNKLVSGPALATEGHPLDDNIVVEAQVSSTPLRTPTPIVNCITGTAPMDHVEWAIDDSIPQPVTAQLNATMATLLDVVDRTRVWGVYCIRPNDSGHANSYDRKRIRSQVRTLQLPELVNRRQVDYVAEYSLSQFCVRHALPVQDGHAAVEDFARHNGWMPGVDYAIGNERIWLAWGAWRQQEDMIRATETRHGSGEETLTDEEGGFMSRNASTFGHGRYGDAVDSTENFRRSESMDNLLARSGTQETYGDGHGGGGGGGGRGGNYGYGGLESPNPNDSEVWETSKDGPYESLNDKDAAAVAAVKRGDFVQSEKRHHATEIVETSRARRWWIRITWTLTWWIPSFLLKWPGGMKRADIRMAWREKVAICMMIAFLCGIVIFYIIGFGQVLCPDMDKAWNKTDLSKHQGDDDYYAAIAGKVYDFTKFYKGQHSDMDFKTTSQIMLQFAGQDLTGYFPPPISVACEGLANKDFTFQKANFTPIMPQAIHTSGVLQTDNDTKLHDENWYWDTLQPKLKKYYKGTYVHDKKDLSQGAAEDPTRFWGTYKSKVYDISDYVATNDLYASGSGYEVKYDFLNPDLVSIFQTSSGQDLTKQIDDLMESWNSDTVNLHFNCLNNAFYLGDVDFRKTARCTVQNYLLLSFSILLMSTILIKFLAALQLGSKRQPELLDKFVICQVPCYTEGEESLKKTIDSLAVLNYDDKRKLIFIICDGNIIGSGNNRPTPRIVLDLLGVDPKLDPEPLLFKSIGEGSKQLNYGKIYSGLYETEGHVVPYVVVVKVGKPTETSRPGNRGKRDSQVLLMQYLNRVHFDAPMCPLELEIYHQMRNVIGIDPTFYEYIFQVDADTTVTPDSLNRLISCAADDQKIIGICGETKVANERESWTTMIQVYEYYISHHLTKAFESLFGSVTCLPGCFSVYRIRTADKGRPIIISSVVIDEYAEPNVDTLHKKNLFSLGEDRYLTTLMMKHFPTFKMKFSPDAIAYTVAPSRWNVLLSQRRRWINSTIHNLVELLFLPEMCGFCFFSMRFMVFVDLLGTIILPATFTYLVYLIIICATHKAAVPIISIAMIAAVYGLQAIIFILKREFMLIGWMIVYIIAFPVYSLFLPVYSFWSMDDFSWGNTRRVVGEGKDKTIVYDDEERFEESMIPYRTFKEYEANAWEAASLPSDEERDEKSDAGYSRRTRRTRNTASNLAPSIHSSAPSYVGSRQPSPGPYGAQLMPMAPMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY54</accession>
    <name>K1VY54_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY54"/>
    <dbReference type="FunCoup" id="K1VY54">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VY54"/>
    <dbReference type="eggNOG" id="KOG3379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_7_3_1"/>
    <dbReference type="InParanoid" id="K1VY54"/>
    <dbReference type="OMA" id="KHEVHML"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="184" mass="20200" checksum="7CB4642DA936DDB1" modified="2012-11-28" version="1">MSRHLFSVFDVTRQDSVIPGHCQPEAAKAGAVQSVGRVIEKAYKAEALNIAVQDGVAAGQSVPHVHVHIIPRTSKDFGGDTDRVYPALEKSEKELKGDLKDQAEGKTPETIAEAANRVASSARGERDDPETHREAAIAAARKKRETEGWQVPRDEDRKPRSQEEMQKEADWLRGLMAQATALPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYJ9</accession>
    <name>K1VYJ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell cycle arrest in response to pheromone-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYJ9"/>
    <dbReference type="STRING" id="1220162.K1VYJ9"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482485_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYJ9"/>
    <dbReference type="OMA" id="EVWCEND"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="551" mass="60700" checksum="F3896318D3965E34" modified="2012-11-28" version="1">MKMIHLPPGQKIGRQTNNKTVPGERNAYFDSKVLSRTHAEIWEQNGKDVKSSNGTFINGVRLSPEGVESDPYELKSEDMVLANYQNDTHNARRGTSLSNSGAAVNPLSHMGPPIMSAGGKSGLNFDDVLHKLQDALNRSKESGQELQGLTTAMTDVQDTLGGGLNGSASQYIPPQFRNPSAEAQAALAGPHGPQAAAFISLQSQITETQASLNLQLDKIRQLEGQIEQQDALKREISVVREQMEESRREMEGILLRSESLDVNDDDDARSVVTVVPGGDSERPPEEEAHDNNLDQVTKVELSNRIQTLETEMAETVQLSKTLQSQHSEALTTVKDLTDRLGKLESGIAERVTTAVEQAEARWEAWRSKFEERWKQERAAWETERDRLRGIVREWEEASRRAAEEEEERVMNEQLSEDDLADEEDPAEDEVDAAELATMDLADSSPRKTTKSRRRRLSTKTALAVRGLRSVANATGSSTPRGNQPAEGAVTEESSKAALNRLRRSSASAPTTVYNEKDSSESGRESADTLRGEKLQEGDADVNAHRNLPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ48</accession>
    <name>K1VZ48_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ48"/>
    <dbReference type="HOGENOM" id="CLU_074425_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ48"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34446" checksum="45FB55030FCA9D72" modified="2012-11-28" version="1">MPTTIDASFFPHIVDLIFDLAPLDCLPLLRVCKDWKRRVDARLYHLRLTQTHAETQFPMPTTYALEGGGGDIAVFKTTLYRKCDPAPPKFVSATKVIDLHVPMFKTDIVRVLAHAGPNVTYRLHKQCNLWSTATWKPECLVLFAKDLAPGDSVAYYTQYGLRTVQGCDKLVVHVRHGGRESLGLNPSTQLKLKRLTVVVHPRHRPSNISGIPLFDPGLIIDLGVLGCTSRAPTTFVMLDESGDKGVATNQVVAGWTSDRIKQRLGYLFVTREVRAPVFMSEAEYRAQVGDEQFEIEINDGHLSRPLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZF1</accession>
    <name>K1VZF1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular serine-rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZF1"/>
    <dbReference type="STRING" id="1220162.K1VZF1"/>
    <dbReference type="eggNOG" id="ENOG502QR2R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010712_1_0_1"/>
    <dbReference type="InParanoid" id="K1VZF1"/>
    <dbReference type="OMA" id="LETHATW"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agd3 deacetylase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="2">
        <location>
            <begin position="512"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="575" mass="63857" checksum="C6599073FCB67AF4" modified="2012-11-28" version="1">MGTSPSERLQWAVTLLVRVFQGGAGPRPVKSRAIGSMMSYERCSPSQRPRSPSLVSLGHSSFFHPILTSSDRARLGRPAREPGQAGDASVSCFPCRCLGLWARARWFTSWAPQWSTTCAAFQHAHIHWLTRGLFLGKRKTHLNIQIDDVELATDMYLPPKAVFRLRPEDLEGHANWQKDLNGRLPAGSNVRLELGHNGNGDILAATDPSSGGVCTPDYAVDYPEVPETELEFKKPLGTGVDFWPKEWTTYPWSYACTQRDPLTAWYKDPSKRDQYFHVSHTFTHEEMNNATGRDASLEIQFNQAWLKQTGIADGMFSPKGIIPPAITGLHNGDVIKAWMENGIKHVVGDNTRPVLRNGESPYHPLISTVEGNGYAGLVIVPRWATSIYYNCDTWECDVQEWKDISKGYGDYNDLLENAKEVNTPYLFSLKADPYMFHQANMRLVDMPTITVGSKTGQMSMVMGWVESVAQEVARVTNWPIVSLKHDDFTQYFLDRQALDGCKPSAVFKTNADGSQITHVEVHADNMNCPAEVPITIPGGGASGGRTDQVGSEPPIIWVKLNGGQATVQLNNPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0N4</accession>
    <name>K1W0N4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0N4"/>
    <dbReference type="HOGENOM" id="CLU_378644_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0N4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="739" mass="80222" checksum="9B68A358598208F6" modified="2012-11-28" version="1">MSVEERLQRLVQPLPPRPPPPIQVQPAIQYSAPSKLAPDHSRQGRSCLPSPSPAASAPSASHIPRLATHEDNRPSHRAHDERSSVQLPWPQCQGNCPRSPSGQACRDLNCALKSPHTPRINYPASPCPSPALPQKVTLSPPSNSDHSTSLFSTSPFPSSPPNTLLQPPSVNITPFAALEHAAVASPEASFSTTILASGESTRERIDFRVHQSPSQHLTPCSTPEVRSQEAYCGYADVEAELDAIAARSSPPRPTVTQLSSNPVVKGRPDTPTPISNMAYNTFPRSKTQFREDPDIFAPLHYDTTYSSRPEPSVDSELLSELVTDTTGERAARREKRRMEKQEKQREQESEKMEKARASRGPPTHAILYDEEERNCGRVPLVFSLVGGVSLPDGSVGPALVAQPQIQAKPKPAVVHSTPKDRQSDTRAQSLRTHHMKAKMPPSYTGQNSRPSSHESGPTSETHGTYVTARGISPAERAQSTQSRPLPRLPGAPPPATATGYDGRYPPLPAQPAQPTQTARQTSVTFAPPPQPAVQNTYTVPATPITNKEPTLDALIAAQIATPHPIPGIHHSVPQRDNVWDDLFATALYGLAYSSLSRNEKKEVQRTKIVRGAQISASGSKGLAKIKAAEVKTGVNVVGRSVAQRMGRMKPARAYTQQDYEFDAVGNMYARYADEVDESWRGGEVRPVPPVKTEREQREQRPASRASVASGRSGRSGHSARTVAPNPNGTDGRRYLEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W193</accession>
    <name>K1W193_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W193"/>
    <dbReference type="FunCoup" id="K1W193">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W193"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="InParanoid" id="K1W193"/>
    <dbReference type="OMA" id="RTKAHQV"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="83"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="343" mass="36931" checksum="B9C874099A686DBC" modified="2012-11-28" version="1">MNKPPGDVFGAWRRLARQLQQAQQQAQQQANRGARSNLRYASGSGGGGSSGGSGGRGPSPLAAAGGAGLLLALVGGAVVVNSAIYNVDGGHRAIKYSRFFGVMPDVYAEGTHMRIPWVETPIIYDVRAKPRSIGSLTGTKDLQMVNITLQLFDLRNPQLDVASGKADTPSYRELGTDYDERVLPSLINEVLKSVVAQFNASQLITQRELVSRLVRDNLTKRAKRFNLVLDDVSITHLAFSPEFTTAVEAKQVAQQVAQRAAFTVDRAIQEKQSIIVRAQGEAKSAELIGNAVRKNKGFLELRRLEAAREIAKVVAEGGNAVMLDSAALLLDVTDNTVLTPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1F7</accession>
    <name>K1W1F7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1F7"/>
    <dbReference type="HOGENOM" id="CLU_829458_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1F7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="38377" checksum="F99E769EA4CCF8B1" modified="2012-11-28" version="1">MTIDFAFYPHILDLILDALYAERDVSTLRTLGLASSALHAVVQRKLLQHVVVRRVLETGSDDDTERSFVWDARRAKARVLDVHDEVFRTESFDEPAILGSFSLASEPNTVRFFSRMHHRFKLPETGLQTAVFNVDIPDSAFATVYPEDDLVVACPLPAIPLNILHLRYDQRGMGDFGFAFEALTTTPPPEGIRADESEPDYSEHEVCVLAKMYDYGPRPKSPWRSTLLNQLATSSLAYLHAFPRATLTLVGMDAWDTWCGSPFPDEEWEPTPPRHFANKAEKVRYFWDWMFEIEFGRRYADIEDIKARVQFETEVDFRERIGAELATLVFEPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3E8</accession>
    <name>K1W3E8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoporin nsp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000252">
        <property type="protein sequence ID" value="EKD03413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W3E8"/>
    <dbReference type="eggNOG" id="KOG4719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257183_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3E8"/>
    <dbReference type="OMA" id="KEPAHNT"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="941"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1358" mass="139249" checksum="F7E772ACED5D8024" modified="2012-11-28" version="1">MSEYRTLPGAVRSPRKQRDNLLPYARPPTTPNANGPTLRRSTSMLGGLKSLFSRPLNWISTPNKQAEQDVEADAARERPALAAGLSPPQGSKNKRGASPESPSDGRNTKRSRKASPEKPVRRRQSLGNLYASSTSTWTPARGPYEPASSKALPSLTPGSLRKANRMSLAAPPSAYLDPPRSMLAPSSPSVRGTPRRSDFAPWDADREREHSALARSDLAHFGESAGPGTARAASLRSHAPRRSDAMMFSNSPFRAGSGFSRSTTAVNLSSIAGDDRMEREGTAQSDVSMRTGSLRGSSRLRQRASMHFDEFGSIPESSEAAHGGTLDWMTSPRASTYSRLSHARSHGSLGQSQRQQPTPIRRGQMVFDAERGFIRESDLEAEKPKPVAQNEAERILFHLEALRKPTKIEKKTPAPSTGLPPSLIGSSSRQLRKAISVPLATQADKEKTKKKHGSEWLADKAISAMISPYGRRRAVDELARSQRRELAASRRAEAESASDVSDMEVDNHSKASSRSRRSTRSRSKSSYASDDMSVDEPRQKLRRSARHAKSPDQEETTPKATRRSTRLRASQAKSPEPTPRRSTRKKAAASPEPEPEQVKTPTKAKADVPTVVTIAPSPSSNSSSTYQVRDDSEPRPRSSLRAGPERKTRAHQGAASYSSSRATSPGTGSGRFSARDEDLPQMDELENAKIPLASFKNFSIPMFGNDAKKDEPKESTTPAAPSEPQLSSRLSVPSSSQSTQQRNAQLSSLGNRLNGLQSRPRASSPLANNSIVAEASSPETTPKKDSAPAPITSAPKSPPPSTGFFSLSGAASGSSSTSLTPTGSTTPAGKPPASNFFSKPATSTTTPAPESTAPKAADGGVPNFFGGSKPTSGASTPPPKLDFGIKPAETGPPVVSNLFSGSNGDALKPTEGSKAPFSFGSTTSVAEKSVETPKPAFNFGAPAADKPADAPKASSGGFSFGSSSAAPAADKPTEAPKPAFSFGTPSASPAPAADKLAETKAPFSFGSGSSTPAASTPAAGDKPAFSFGAPATSTDKPAAEKPAFSFGSASSTPAPSTDKPAADKPAFSFGASSSPAPSGGSSFGSVAPATDKPAFSFGSSTTATDTAKPEEKKDKPAFSFGSSSAAPASSGFGSSNGSTAPAADKPAFSFGSSSASPAPAAAAPSSGGFSFGSSSAAKPAEAAKPFSFGSSNAPPTSTPSVNGGDKPFSFGAPSTPAAPASGSAPASGGFSFGSSNSTPSNNFGAGSTSNTFGSTNNAAAPSTPSFTFGASSSTPANANAGSSGFGTAGASSSTPGGSGSFTFGAGSGFGSTNNASSSAGGGSGFGSGPGFGGSSNNSPSTGATSGFGVWMSGRKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6M0</accession>
    <name>K1W6M0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A Chain A, Arylamine N-Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6M0"/>
    <dbReference type="STRING" id="1220162.K1W6M0"/>
    <dbReference type="eggNOG" id="ENOG502S76B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="InParanoid" id="K1W6M0"/>
    <dbReference type="OMA" id="CYEHNTL"/>
    <dbReference type="OrthoDB" id="3349226at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.10">
        <property type="entry name" value="Arylamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.150">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="315" mass="35010" checksum="191F1198E93C0E00" modified="2012-11-28" version="1">MTHRPRNSGSASSQPLIHTSSSSTAMSLGDRYLNLLGLERPAKLDLAALTTILHAHLRAFPFENVTPFSGIPVSVDTEEIYAKFASGRGGYCMEHHQLCQPALADIGFAAERQMARVYVGTNERALAQTHQVTLVTFPDDSTYIFDPGFGATTPKTPLCISSGPEPQKNEWQTLRVVPATHDVVEKIGAAKVGEDVHLIVESEFEGNWMPQYGLTRPGAVHADIEAFNWWVCTYPKSNFVTNLMCATWNGDDDRVTVGGRVVKKRSPGRPDQVAVMDSEEDARKWLVEEMGLRLSEEELRRCWEKLSTLPRPEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W724</accession>
    <name>K1W724_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W724"/>
    <dbReference type="HOGENOM" id="CLU_444953_0_0_1"/>
    <dbReference type="InParanoid" id="K1W724"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="234"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="614" mass="64475" checksum="AFE9BED05CD96F20" modified="2012-11-28" version="1">MSTPKRTYANAAATPPRTPSPQQLTTVTANKTILRAGVITAAPRKRLTAPSASKAKKAPAAAPKRGHKTNNVKRGDKVKHGAIAPRARSGTPSFCASSGNVRGATDVARKKAPARPAAGTIHGLCRAGSPVSLPSRPASPELASETVESASGSQKRVRSATPTSSSSSSSSSDSSDSSMSDETRTVPGSRSADAGRSGRKARSKDMSAATERYIPSGRSPLERQIQAAARVHGYRIEEVPGDGDCAIHSIKRVLPSLTDSVAQIRANMVSRLLHDVQESNLYEITVAAYEQEGVDVVEAMSKAERKLRRRFRKYRPIGPRGGEWIDNETLVGMARHYDMDVVILNTNASWTVVEATPGQAAPRRAHIALAGEHYRPLVPSASDSDDASAAIAAAPPQFLATASARLTHRRACLQAVASGNGLVPATDAVDQLEFAARSATTSAAKRATAQMLVQRVAAAQDRLALARALVPEPDPVAPPPGRRKSTTTASPRGKDSSSTGRGRGGSGRGRGRGRGQGQGRGRGRGRGKSARERSSSSLPPSPSLNNLTGQDLEAIVSELVRIARAVPSVEAKWRACLERDLESIEDEGTKAAISDLLNSTDGLSTTLPRSSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1W775</accession>
    <name>K1W775_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W775"/>
    <dbReference type="FunCoup" id="K1W775">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W775"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="InParanoid" id="K1W775"/>
    <dbReference type="OMA" id="VTNRNAI"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="499" mass="55099" checksum="CB82AB04C28A1D18" modified="2012-11-28" version="1">MPLLRSLVSSPLLRTSLSANTVRPFVRMSSSVPVPQDFNNMLYQTLEQYDPEVNDLIEKETWRQFSGLELIASENLTSLAVMQANGSILTNKYSEGLPGARYYGGNEYIDQLENLTRERALKAFNLDPAKWGVNVQPYSGSTANFAAFTALINPQDRVMGLGLPDGGHLTHGYYTAKKKITASSIYFQSFPYRVDPQTGYVDYEQLSTNANIFKPRLVVCGGSAYPRDWDYKKIREIADKQGAYLMSDMAHISGLVAAAEQNSPFDYCDVVTTTTHKTLRGPRAGLIFFRKDKEPDMESRVNAAVFPACQGGPHNNTIGGIAVALKQAADPAFKEYAIQVRKNAAAMAEVLFKHGYRLQTDGTENHLILWDLRPIGLTGSKIEKICDEVHVTLNKNAVAGDTSALVPGGVRIGSSALTSRSMKEKDVEQVAEFLHRVVQISLKAQEKAGSKKLADFEKAYKNDAEVAGEVKQLKEDVKNFCTSFPLPGVPDTTTIKRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7I0</accession>
    <name>K1W7I0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquinone biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7I0"/>
    <dbReference type="FunCoup" id="K1W7I0">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7I0"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_2_1"/>
    <dbReference type="InParanoid" id="K1W7I0"/>
    <dbReference type="OMA" id="HENICKD"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="301"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="680" mass="74498" checksum="0E15B013DFE9B0E4" modified="2012-11-28" version="1">MSKGMLSAAARVWSRAAALQAEEAVMMASPSLRPQIYEDPVVYRPPPAVPRRAFPPPYPPPRAPPSTSRPPTGPAHEHQDIKEQDEMWSDPRRHVEVEVFDEPAQPVKAQPQVEKKPAQVERPAAVSATVAALQKQADKLESQYTAKPSPRPVPVAPAVKTAAAPTPTPKPAVAAATPEVKKPFVVDPSVDPMTYLPQVEADPEDVPVVLRSSAVPSSRLGRLFHYGSLGASLALGAAGETFRRTTGGGGQGSVFMSDANVRRLVATLGRMRGAALKLGQFMSIQDNTILPPELERVLAQVQAHANYMPDWQLDRVMTAELGPEWQAKFLAFDRTPVAAASIGQVHRATLKDGTHVAVKVQFPGVAESIGSDIANLSIVLRGSALLPKGMYLQNTIAVMKRELEDECDYEREADAGKKFAALLEGDSVFDVPRVIEECTSKRVLTTEWADGRPLSKLRNLTQEQRDLVRNRGQPQAVPWRLSCTDSFASLESLANGQIGTNVLRLCLEELFKFRFMQTDPNWGNFLFLPSSGRIQLIDFGASREYTPEFMAGWYKLLSAALSGDKPAMVAESQSLGYLTGEEEPDMVDAHIASMSALARPFQHQGLYDFSKQTVTDEVRANIPVMLEKRLTPPPAPTYSLNRKLSGAFLMCAKLGSQVDCKKLWDEATETYQREFAQAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W898</accession>
    <name>K1W898_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W898"/>
    <dbReference type="FunCoup" id="K1W898">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_0_1"/>
    <dbReference type="InParanoid" id="K1W898"/>
    <dbReference type="OMA" id="TSAYCFW"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="881" mass="99773" checksum="48695665F413FF99" modified="2012-11-28" version="1">MGSSDIETYNEKGLAPTAAHGRVASPDHEKKGDLWVDDIKVVAADEDAENAAHNYGINATAEELADAEEKIGDMSLEKCKKIMHEVLLMHQHDQNFSTELVNKIKQLLYDPDVTEHPERHANLIHAMKLEAVMATENSPYEIVRGVVDNFDDPSIPSLTFRTWFIGLLFAGIIGLVNQLFSIRYPSIAISAYVGQLVAFPLGKLLEKIMPTKRFNLFGWHFSFNPGPFNRKEHMLITIMCTIVQNPPYTGNIILAQALPIYFNQPYARTFGYQLVNTLASNFLGLGMAGLFRRFIVYPSFCVWPVQLATLALNKAFHQDDSAAVAGPFKRFYYMSRLKLFYWAFGIYFVWFWFPNFIAPFLNTFDWMAWIAPDNVNYVSMVAVGGAGLGLNPFPTFDWSQVQAMLNTLTVPLFSVANQFLGVFLAMFPIIALWYTNTWQTGRFPILDNHTWTNQGKSYNVSMVTDSMGKLVEEKYQAYSEPWMAASNLMIYFMFFAGYSSMVTYTLLYHRHEMTIAFKQSWKGLKRSLRRNKDHDDEEEINLAEDVHMRLMRAYPEVPEWWYLIIFLISFALGIVGIAAFPTGVSPAIVVFGVVLALIFTIPTGLVSAVTGGNITLNVFAEFVGGALVPGDALSMNYFKMYGYIVSAYAINFCGDLKLAHYTKINPRHTFVTQMAATLLASFVACAIFNFQMSFKDVCTPDAEWGMQCPGENTFFTAALFFGLTGPRRMFGTGGRYMLLLLGFPMGVIVTVAVYLIQKGFPSNKYMRSLHPVMLFFGPLNFWSAPYNLSHMWICYFWTWVSWGFVKSRWLAFWNKYNFVFAAALNCSIAIAALVLFFCVEVPGAEMPAWWGTTVVDTVKRQPRITELPARGYFGPERGTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8Z8</accession>
    <name>K1W8Z8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8Z8"/>
    <dbReference type="HOGENOM" id="CLU_107275_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8Z8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="225" mass="25265" checksum="90091B6FC27AB9CC" modified="2012-11-28" version="1">MRLHLSGEAEAVAQLCHVVKDWSCMTREAPRHRSGERTPAQSALERQLDRVDTHLLRKALRVKMIQLEVVRPGILTPRLNKDPVYCVQSESVAELEPDRPLPAAYRLSVRHNPLQFRNDSRVAEREYEYADVDCEAESDGEVAAAEPRIAQCRFCHLLDEFETNQGACLVALEQVPFVFEGAAHEVEDLDRVVRGTALAIFSLPLDAMLFVMKDANAFKVGAGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W915</accession>
    <name>K1W915_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W915"/>
    <dbReference type="HOGENOM" id="CLU_314537_0_0_1"/>
    <dbReference type="InParanoid" id="K1W915"/>
    <dbReference type="OMA" id="RPEKMYS"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="930" mass="98278" checksum="B012A9AAD82F7A19" modified="2012-11-28" version="1">MVSEWEKERLATNLRIVQSLIRTLRSFNWLAADHPLPADVVVARKAQTEGGIRPISVAVKTAEKLWRKGAGKLKNARLLQFGDSRDCRISESIAYLVKAHLECWPWAASPLIMSANEAYAQGLSQLEPKIWVALMEACFCLHNPTLRPRNSEHEPSLERQGPEVDMNYAGMTFARLCAVALVNAPYVDRDNLSKGYYGEFTLPTVSVVSQSVALTEGVAIASQFFPWLEGDAALALQGLNSTLNPITTNTIDGWAHAHCNDGHHSCQRRAAARRKDVDDGKALEDLRRKWEAEYRPPKTSSSPPSSRGSSVSQVSYLVNGPQRNREGLRHMRAQRASASKTPEQGAAGPGPRLTRSKRNRVTFADSDIEDGEPEKDVSGSGGRSARRKRKRTTVDASGSDVGEESLAAPPQKRQRQNDGKQIASSAAIATTNEAAAAAAAPTTKPAPENKVKGGKLAKVTRRQGAIPRETFYGKTNGYGPRWRVTRPGDTPQAVNPAAGLGGVHPATRAQATPAARGEAIGLATALRAAKGMANLRAAGVNPIPQAAHPAAKRKAADAARTQAADSQAVGSTTRFQVVNIAASPQNPAPASSPAADLATRIRDANTAALSQAPHPATRAQATAAAQPQAATSATKAQAVPPTTRVRFATLDTEFKAANPAARVPAPKAAVTPAAELRPARPATRAQAAEPQAARPATRARAVISTASPEASPAASPQAVEPPAARPAPRTCASNSAARLEAGDPAASPTASPQARRRAAAAQVATASAVATPVASPVATPVAAPATPSATPSANTAPEQSEQSEQSEQPEQPQRPVRQAQAPRKPLKRTGWVTSSPPRSPSPVAHAPPEDENEDEEEDELEDFDPTPVKIKTEPAEQPLPPKKKAGRPPGRFFAKRSSGPPGVSRPGPPAHSTVMTRKAKLKRSNSSRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1W994</accession>
    <name>K1W994_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W994"/>
    <dbReference type="STRING" id="1220162.K1W994"/>
    <dbReference type="eggNOG" id="ENOG502S607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572653_0_0_1"/>
    <dbReference type="InParanoid" id="K1W994"/>
    <dbReference type="OMA" id="GHEMATA"/>
    <dbReference type="OrthoDB" id="3261505at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852797" evidence="7">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="477" mass="49455" checksum="7480224604DB7393" modified="2012-11-28" version="1">MRLSTLILPVAVAHVAMAAHVHVPQRRPAHMYRAMERRQHGSSEDDFGVLPSPSSGAGASSSSAEPSSKAEPSSSSTPTKPQQSSSKDTDTAPTSSAAPTTSNASPAPTSSSTSDKDKTTSTKPSAAPSSDVSSDDPTSSESSTSSPSAKPSSSSEAATSESSVAPSSSSSAAVESSESVATSTTASASPTALTSARTLTRSASDTETDTSIAPSLATRTRTATKSATASSDESNKDDKESGGLSTGAIVAIVVCAVVAGAAFLAWTLFRKLKLKNNRFNDRSQPVDFSPDNGPMGGDDLFEKSLQRSASVASADRQRRELVAELDHDNSLTAGIPEHDFTAGAAQPYGYGADPYNNGYDFSSPRNEGYDPNYGYPAHPDQAAMYPEHGYAGEYPTQDTYHGDRYQQNGYQQQAGYTGDGYSPTERGGPTSPLSPHGHAAQPQFDAFSGSDFEITARPTGGAMGDAGPYAQAASYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA53</accession>
    <name>K1WA53_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA53"/>
    <dbReference type="FunCoup" id="K1WA53">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WA53"/>
    <dbReference type="eggNOG" id="ENOG502RXY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032651_1_0_1"/>
    <dbReference type="InParanoid" id="K1WA53"/>
    <dbReference type="OMA" id="RLVMMEL"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="225" mass="24678" checksum="A3CF1CC5789246F9" modified="2012-11-28" version="1">MLELLRPVSVGGGHLAILDSSFNPPSAAHHAIASSSFPGHPGCERVNYTARLLLYSPRNADKVPGSTDATTEQRSEMMRLLADHMSGSGQETGAALLALPTFAQKADHLAQHFPDSHLTFLVGTDTLTRVFDPKYYDDMDRALDHLFERAHLVCCARGADADAVLNEHPKIRDWAQKGNVRFIEAVGEVSSTAIRRAVQEGNWELAERLCAPGVGEYVRQEGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBQ3</accession>
    <name>K1WBQ3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBQ3"/>
    <dbReference type="STRING" id="1220162.K1WBQ3"/>
    <dbReference type="eggNOG" id="ENOG502S0DZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420461_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBQ3"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="161"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="652" mass="70423" checksum="F09F90662C0A4976" modified="2012-11-28" version="1">MSAETPPFHTPSASVPPSALPSRSGTPLMDRTNGTNGMDRVGSTGTLRTMVPSYSASQATLHNGANGTNGVNGTNNANGNTTNRQSLPPSGLGGIQEKEKPYSVPNPPPATHTVQLDTEPNRVLVAGKDQTPGEVDPALKPPKVNKKLEYVIKPMAIAATVLLIVLWATALWIFGCNHNAQHRAYKLKVRVRDFDGGVVGQTLISTLNSTRTKEAPGWEIMDGDITDVVESVWDGTYWGALVVKEGASAALQQALANPTAGGYDPKSAITNYLTGARYFTTYSSYIRPAITQALAEVSAKMSGYAANVALGQNTGANSAEQNEALARLIAQAVGFTETDMAPLPFQSRVFINTFGVVVPNLATFFFNMIIMGVFTEAGVYSHPTTMFKLTRAKFVLKVVWCVLASLIMTSVNFSFREDYTYPAKNFFALWTDTLFYCWINFNIFGTILAYLPIKFIMYFVFPIIVTSVAAAVFPPEVGDIFYNISYIFPSHAYWAIAITIWGKGCCNRLSTYCPVVMAWVIFTELIWLSGDWHLSRKSREGAGVPPPPPDGGDPITEIVFSEEEIPGDTRPLSRSLSARIASRTRSPTSFGSPGGPGAHAHLPPGDSVPRQYRVPVWQDSSSTVPSQQSQASQPSPGIQQSPGVQSSPGVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD88</accession>
    <name>K1WD88_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD88"/>
    <dbReference type="STRING" id="1220162.K1WD88"/>
    <dbReference type="eggNOG" id="KOG0897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371800_0_0_1"/>
    <dbReference type="InParanoid" id="K1WD88"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="391"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="748" mass="82269" checksum="928CDE0C64472387" modified="2012-11-28" version="1">MSDSQPPAKRSKRSHQRNLTLDSSHDISRGSASNPIKIMDEPTDDLITWEDGSDTDPFAAPSSEDDDVNGLDLYDSDPADDDAGDFLDHGDDLTLEDAEDNSLAVLGQAMLDEDIEEAKALLAHTRLVVQQVANSIEVVLPLDELSDIARAVSGLTSLKPITVRLSVHGGYRRTSPLPVVKVQHEESVTTTERICRDFIIGLQLCKVAQNYLVQRWEKRGEGFLSALAELLADRLANSGNHCLMCDAALPFPGLKPTVCDQSFCSFQLEEMGIGSSLAQFEMDPEVADLLLTLAVSACLDSYRLTVSPIKFPLNGLSGQPYTGDELMQVVNLVPKAQEVLEMGAKRKEKLLELSPHTVPLVSWIFATNRAHITSMPEEDYFPKMASTIEDSTMRQFQIETSTRAHAEKFEALKAAHGSFYAFHGSSMSNWHNILRQNLKNASRTPLMSAGAAYGEGIYLSTQSNVSKSYVYGRLGNAFAMPTAFTTGTAAASKAPSSFSWLNSELGANPVCLALVEVASSSRVHKHLHDTIIVASDESCVMLRYLFVYSSANAIPNVTAAEVVPKRYKNEKTIAFQSTLDEVTASGNLLVTSDGYFWDIEEVVAMVKAKNGLFINGFNQLSFAPEDVRAILNHRTGLGRELKKLERENAKLRTSIPRDLLARLNRHGQSCVRDHSAEFTTATQVIEEVRQLIENTTPAVKEALAKVPFEAIDSHTRRPFRDTITHALEMVTSGGECVHRFGDFLSQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDI0</accession>
    <name>K1WDI0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDI0"/>
    <dbReference type="STRING" id="1220162.K1WDI0"/>
    <dbReference type="HOGENOM" id="CLU_593372_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDI0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="461" mass="50457" checksum="AD2BC2B785914DA8" modified="2012-11-28" version="1">MLGGRRGALPDGDSTRMTTSSSTRVRRRLDRRAMPTNVPLNEEGFEDADEFFRSSPQSGPSSSRHQTPAARRSDGSSPSTVRTNRSRRSRISDMVADEDDEAFAENLLADDDDDDLGGTPRLHFPSSPSRLPPKSPSVGFDAIPSPSMSFTARRSTIGVNYRPLEPRLSPTTPLRNEVSGLHSPPALEADEDDMGQGMEVDISAEFEEDVVEEVSFERRTIEDDGPGEAEEEEEEEEEEQINEPKTPQATNSGKVRDPGLRTSVHGKSKGPIPDEEDDEDEDVNNRSFQEPLDDVGGDGSGVADTYDDYSDAGGPEGGFEVNDQDDLPAEDDSNYDIDNTVNIDNTADDIDHTMDDIDNTVDNTVDTVDSADITADVTGFMDDGGDEEGDVSLERQAIEEEDMDEEDEGDVTAISQERTPRPKSRPKKKKDASTPRSPADLPKPKRSRISQLPDSEFIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDP9</accession>
    <name>K1WDP9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000365">
        <property type="protein sequence ID" value="EKC99723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDP9"/>
    <dbReference type="FunCoup" id="K1WDP9">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WDP9"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_1_1"/>
    <dbReference type="InParanoid" id="K1WDP9"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="218" mass="24258" checksum="ADCA1B72B5BD9D6B" modified="2012-11-28" version="1">MSGWFSYFTGRKNVKEGARDSIINLRQSLLTLEKKEEYLNKQIEDDLKKARANATTNKQAATHALRQKKLHEDQLDKLAGMRLTLETQINALESANLNAETMAAMKQGADALKSIHQTLKVDKVDETMDSIREQMDVANEISEAISNPVGMGATIDEDELQAELEALEQEELDDRLKGANHVPSHMPALPASPIRQHATADEDDEEAQLRKLQAELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKS6</accession>
    <name>K1WKS6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cef1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_03811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKS6"/>
    <dbReference type="FunCoup" id="K1WKS6">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WKS6"/>
    <dbReference type="eggNOG" id="KOG0050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009082_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKS6"/>
    <dbReference type="OMA" id="KMGMAGE"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="769"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD01884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="827" mass="91994" checksum="472BE4C8FA1E71D7" modified="2012-11-28" version="1">MVRVIIKGGVWRNTEDEILKAAISKYGKNQWARISSLLVRKTPKQCKARWYEWLDPSIKKVEWSKTEDEKLLHLAKLMPTQWRTIAPIVGRTATQCLERYQKLLDDAENAENEELGLGDGENENSKPAIGGLRVGEIDTDPETRPARPDPVDMDDDEKEMLSEARARLANTQGKKAKRKARERQLEEARRVAFLQKKRELKAAGINLRQTKKKKGVDYNEDIPFEKQPMAGFYDTTEEKAKTYAPLIGHSLKSLDGKRRQELEEAEAKEAKRRKTGEDKDKAKPGSATAFVQQREAQIRKLKEQERAIRRKALNLPTPQVGEAELEEIVKIGQAGEAAKELVGSTGGATDQLVGEYENLKQARMARTPQVASASGQDTILAEARNLRNMSSVQTPLLGEENTPMHEEAAPGAGYSATPRHNVASTPNPLATPARGAMATPRGLPGATPLRTPRDNLALNTPAGAGWGETPATDRRRMKDARRALKAGFASLPKPENNFELTDEVEEDEEEDEDVPLTEEDAAERDARLKAAREEEERLELARRSQVVKKGLPRPANVDERALLRQLNSTLDDVDASLTAAINLINVEMAQLMKHDSLAHPVPGSSSLQPSEYDMPEDEHVASAKGLIHAELAGALGLPGANEEQVRLVIGSQAEETSDAFVDSWSEIAPKFVYLPGMGWVDPADLSPEQRRQAYSAMIGSSKDRMIASATKATKAEKKLSKQLGGYNAINAKTRASILSTMEEIQQTQRDLETFEMLRTMEMAAIPSRIEQKRMEVDKLERRERDLQDKYGELIDERRRLTESIEGLEEDKVVLEAQIALEAQENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WLK3</accession>
    <name>K1WLK3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WLK3"/>
    <dbReference type="STRING" id="1220162.K1WLK3"/>
    <dbReference type="eggNOG" id="KOG2768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_0_3_1"/>
    <dbReference type="InParanoid" id="K1WLK3"/>
    <dbReference type="OMA" id="QTGPTWE"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="294"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="424" mass="46174" checksum="56003F1A76BC3932" modified="2012-11-28" version="1">MWHPTGTQLSITVQRDQIDHMAPSSSTQAELTDSLLCSKPHRLDIPAPPPPPPPSACSSPHPSSNTCNKRAGTTPSTPPINTFRTPPPFPPLPQYSAFPPFSLIHSKLTITVADPVIDSFAGMKKKKKKVALDLDNEAPAPAAEAPAASSSSAPAEDAPAPAAAAASDEKPAEEGDMFADLKKKKKKSKKDIPLDLDNAESPAATGDDVPIVKKKKKKPAADFAKELDELEAEKNEEEGGDFGDDVFKTSGEGAGAEGGVDPWVAEGRDPSYNELLKRFFTLLHVNNPELAGEKRRFTIVPPQVTREGTKKTSFANFVDICRRLHRQPEHVLMFLYAELGTQGSMDGAQRLVLRGRFNQKQIENVLRKYIVEYVTCKICRSPDTLLGKENRLYFLTCESCGSRRSVQAIKSGFQAQVGRRPKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMP9</accession>
    <name>K1WMP9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerases ii 24 kDa polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMP9"/>
    <dbReference type="FunCoup" id="K1WMP9">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMP9"/>
    <dbReference type="eggNOG" id="KOG3218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_0_1_1"/>
    <dbReference type="InParanoid" id="K1WMP9"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="211" mass="23670" checksum="BAA106092F74C6DA" modified="2012-11-28" version="1">MSMDSDRELARLWRVSKTVHEMIRDRGYEVADYEINMSFDDFKETYGGGGSVDRGRMAFHANHSRDSRDRIYVFFCAEEAVSKATYKSFVTSLDAVGAKRGLIVHGGKLTSGAAKTQNEMQSEYHLEDFKEADLLVNITRHFLVPKHTIMGCLSFAWPEGMCARPTYWLAMQRHGIDIRGQPSIRAPAGLRTPPAGYQPGQGFGKGTKWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNS4</accession>
    <name>K1WNS4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ceramide synthase component, Lag1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02904</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNS4"/>
    <dbReference type="FunCoup" id="K1WNS4">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WNS4"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685477_0_0_1"/>
    <dbReference type="InParanoid" id="K1WNS4"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="179"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="379" mass="44239" checksum="9F4F53C2500AC24F" modified="2012-11-28" version="1">MAESSSLKAPAPPVNRRRSSSVTSALKLLQQRGRNMRSAAPESYEPSVAATTCHISVCLFLHFPQRVHDSDCQANPAQWAVRQSREDRGQAAAKERPSSRPWILIDLGMTGPIKFNPFKYLLFPCNKQPNGKYTKGLGDLAFIAYYIVFWSFVRQFVTLYILRPMAKRLGIRPAKVPRFTELFYFGIMGVAGIASAAMQASLTADWNEPPPDLVVQDRVYYLMQAAYWCQQTIILALKIEKPRKDYKELVAHLAKCVNYWNDPASTPFFAFFVVVWTYMRHYLNIKILWGVYKYFDLIPVDQRTVWEPLKDNWMVWWMKWQIFAPIFLLQCINLFWYFLIWRILIRVIFFDIRKDERSDDEDEEESDPPKQVGDADKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQC8</accession>
    <name>K1WQC8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQC8"/>
    <dbReference type="FunCoup" id="K1WQC8">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQC8"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="InParanoid" id="K1WQC8"/>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="392" mass="43694" checksum="75B4787543AA376E" modified="2012-11-28" version="1">MLGLAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKQNREKMTQIMFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGFSLPHAILRLDLAGRDLTDYLIKILMERGYPFTTTAEREIVRDIKEKLCYVALDFEQELQTAAQSSKLEKSYELPDGQVITIGNERFRCPEALFQPSFLGLEAAGIHETTYNSIMKCDLDIRKDLYGNIVMSGGTTMYNGIDARMQKEITALAPSSMKVKIVAPPERKYSVWIVSIPSTSRARPPRNVVERRQRHARAGGSILASLSTFQQMWISKQEYDEAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQE6</accession>
    <name>K1WQE6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Siderochrome-iron (Ferrioxamine) uptake transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQE6"/>
    <dbReference type="STRING" id="1220162.K1WQE6"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_2_1"/>
    <dbReference type="InParanoid" id="K1WQE6"/>
    <dbReference type="OMA" id="REWNSAN"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="609" mass="65294" checksum="09FDF14308D7CBC5" modified="2012-11-28" version="1">MPSSDKDAKTHSEPDADRALGVMPNLNQERVETEAVSPGVLRIKAMVAVMTRGDFALLCLGVLLVAYIRNWNAAQQTATISVVYSACAASSQPVWAKMMDYFGRPFVVYASFLFYVVGCIIMAVSSNVETMCGGRAIYVFGYGAQNCRLHEEAETDAQCSCMSSLPTPQVCVTVSSSHPWSGVVGAKTLSNAGWRWGYGIQALVYPAALAPFVVLMTRLILRARKRGTVANIPTTGALLKKKSMWRDILWKADVIGLFLLSAGIALTLIPLTLGGGTSAKWKTAPVLAPFLIGIVVVVPAFIYWETKAPYPMLPFSLLRQRHIVLSLLSGLLSTITGAQQSTYLYFALQVAFGQGVEGATRISKLSTFSSSLTVVVLGLVLMYVRRPKPFAIAGACLYAVAYGLLYHFRGGHDKGTLGGLIAGEVILGIGSGLNQNAVQVGLQAAVRHENLAIITATYFCMFQIGAALGAAITGAIWTNTMEARIRAGLESVNAPNAATLAKQVYGNPLKFIQQYKPGTELRAAVDEAYRSEMRLLCISGLAFSAALVIVSLFIGNPVLTDKRSVEDDDTDDELPNIAGTSPTSTHSDKYAVEDKEVTQHAKSWGGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRU4</accession>
    <name>K1WRU4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRU4"/>
    <dbReference type="FunCoup" id="K1WRU4">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRU4"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_2_1_1"/>
    <dbReference type="InParanoid" id="K1WRU4"/>
    <dbReference type="OMA" id="WILISAR"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="72"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="208" mass="22619" checksum="2EFFCE3BF4D1703D" modified="2012-11-28" version="1">MFRPRASALAAAAAAPRRLFSSAPVRMNGFADLAKITGTQTAAASPFGQTETATQDNIRGYRPRILPAEVDPTLELFTNLLMHSGKKTAAQKQMAAILASVQAATNAPPVPQVKKAIELAAPSLRVLTMKKGPKNVYTPRALNTRQRTRIGIQNLIATAERSRGSQAKFSDRIAREILLTLEGKSEVFKRVEEVHKLATLHRSNLLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WT83</accession>
    <name>K1WT83_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WT83"/>
    <dbReference type="HOGENOM" id="CLU_769848_0_0_1"/>
    <dbReference type="InParanoid" id="K1WT83"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="33726" checksum="4C133238F560C144" modified="2012-11-28" version="1">MSVPSATTAAMHAPVFVPAAPAQDDAAWSVVAPSPTDSATPTPPALATPAVSSTQNAAAWGKWPAVPTPSVDTSWSDTDTPAAPSVVSSHASKWVKGDCDIVTADGAVLTVPSYHLQSASPVLRKKVEASRGWAHASVAVNASAETVEAFLDIVTTGEVALQWTSAGAAISSVARLAEFLGRYQCEAAANILVKHLKEQAGSVLPPISLLLAGIHLKRPELTQFMLMRHDVPEPQLWCLPSPTEHGTMPFVPFEVYSLIPVEYQWALRMAGIQKGEQSPKGGVYGRFCQYLEQAQKHDKVKAVESPVEEESEWDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVG8</accession>
    <name>K1WVG8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP23 sensor motif region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVG8"/>
    <dbReference type="FunCoup" id="K1WVG8">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WVG8"/>
    <dbReference type="eggNOG" id="KOG3164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053567_2_1_1"/>
    <dbReference type="InParanoid" id="K1WVG8"/>
    <dbReference type="OMA" id="CCMQALY"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="3">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="303" mass="33229" checksum="E315A4B910E66B89" modified="2012-11-28" version="1">MRQKRAKAYKRVMALYVSTFGFRLPYQVLLSDGFLLESAKQKDIDTLAVVRKVLGLSGNDTRDTKFMITQCCMEALYKLGKEYQHVVNLAKTAERRKCNHREAIDPTQCIKEVVGETNKHRYVLCTASQKFLGSMSRVPGLPIVHYNSTGVLVLSPPSQATVRAKLAQEEEKRKAGAELLDGVVDGDNVKGAPAASTTAEAAATRSRKQGPKAPNPLSMKKKKRKVEVEEQAEGEKEGDQGENGGEDDGGRRKKKRKRGRGKGAVAEAISEIRAEGEEKRLKALEERAARDAPAGGDSDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WX69</accession>
    <name>K1WX69_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WX69"/>
    <dbReference type="HOGENOM" id="CLU_412318_0_0_1"/>
    <dbReference type="InParanoid" id="K1WX69"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="666" mass="75113" checksum="FFA9840B6A7376EC" modified="2012-11-28" version="1">MFFPPWYDYVWVDPVWKQHHGNDIQPSWHFLPLVSAVSPCTATEGKVIGSNLCRAHHEKRLNADHLWRFWPMEEALLERERQGWRFACWVVGGYGDPDSCMHVYLPHFVTGGWGEYEPLDDRLRMIVFYERERLNSNLRLLADLVHTLTHAGWLAAGPSPLEILALKRRGPVVSVRKSSRRAARVRLEAVADLKAAWGLPHGRNLMAISRAIRKLVEAMLELWPWSSSPVIMSVSEHAIWFDLFVACASLHDPRLLPEIPGSGPRPELRTEGPKADIRYAGMTFARLCALALVHAPFVDVMHLNRGYYGVELTSRFFPWLADEGRIARRGISTAASTEALKVADWAHSDCDRDHYRCQFGRWPEDEVQKLRAFREHPPKWWSNVTVGNQAPWWLGLQVQQQWAEAAAIRDAERESAAKAAQCAMLVRLNRDMRRLMIRIRDDRASEEMRSRQTGLRCLSRGDDGAAAAGTAPALAQTPIPAPNAEEPQYRNELLEMERQLLWEMFESLTATLDDEELEDAWGAFAPYRDDDGDAVMGDEAATESNLSDSPSHPAFHAIADEDSESISTISDLDDRQSVLFTPSPEPDLAHEPESPVPPVNPSTLASNSSCAWFVGLPSQHKVPMLAFPDKRVEMEFTTSRVVDMGENFQLALGGVSGVFYLPAYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1V046</accession>
    <name>K1V046_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V046"/>
    <dbReference type="STRING" id="1220162.K1V046"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451425_0_0_1"/>
    <dbReference type="InParanoid" id="K1V046"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="605" mass="65350" checksum="7D06A658D0010768" modified="2012-11-28" version="1">MGFGSHHSPQFGTTGVVLNATPTVVSTFFQHVFTWPTRHKSRNAPSGSESPTSIGTLPANQMSYDQGLHVVKQFLDYASEHGVEELQGFSAQPLPIPLVKVPDENIERATVILTEQLSKYADGKGLELVGGKKWWQVRGRPLEGEWIEHYQRRMEREAANGQPNGTDRADKRKSWRHSTLGSFTSSRTKPVLDGSGAEVDTDRVIMYIHVSIRKLPDTAWKLTSQPCGLLDSLAAYLYLIDPPEGKPIDPANIILMGDSAGGGMCLSLLVVIREMGLPMPAAASLMSPWVDLTHSMPSINQWDGGDYIPNVGFHYRPSLVWPPLPVPDNGVMVKLADGTEKEVDDQIQLYCPNNLLTHPLVSPINNGSLGGLCPLYIVGRDQWLGLMPDCRLSRTAARRSDLRRAQGGRPARLPAQPRDTGRVSRASTARGRLPADEGAPAGLRGRMSRRDDAGLDPERKVHLPRNRQRGERKRRQRSVMGGAEVAEPLSMSRSGSEGGVTPQRSTSLGMTPAGSGATDEELSDGTASEPESPSATSPSRRYFSRHKPLDHIPIQAFVSEQILLEGCVEVVFVLDKDMAEGGGAGGAGGAGGIAGGGGWCHADPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3S2</accession>
    <name>K1V3S2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peroxisome targeting sequence binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3S2"/>
    <dbReference type="STRING" id="1220162.K1V3S2"/>
    <dbReference type="eggNOG" id="KOG1125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013516_2_0_1"/>
    <dbReference type="InParanoid" id="K1V3S2"/>
    <dbReference type="OMA" id="YTNENDR"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="814" mass="88882" checksum="D61904A1B741A693" modified="2012-11-28" version="1">MSNFLGGSAVECGPSNALKDVGALVERDYGAQRDRYAPTAGPSAGPSAFRSRPQQQQAGPAPNQAFDLSQLRSHLPAQPQQPVHYAPQHANQSQAGPALAPQGHAGQNWADGFTADKGKSREWGNEFETSRGSPLQATPRTASPSVAPWQRQNVVSPGPSMYHSPMPYQPMFQQTTHQHMMHQYQPAPQRMREPTHAPPPIPQEKQATQSPDIVKAYEAELVEERQELESRADIPQDELARTAQALVDQLKEENLMKSDPKLANSEFVRLLRGLGSGDIKVQEGDQNAVGDEVVGDGAKFVNSAGADWAADFMSTEDFGKSASEAGLQQTWERGVQDNIAMRDGMGATQQRRKSVHFDEDKPMVADTHVAGAGQDWEEQLDDDDFDTELLRHFNGGPRVHETQPTIAETQQNEMWEHAETDWDEMIRQHSQPPAPEEYLFHRSNPYANGGPIVREMSPTTMGVLELEAAVQQSPRDGSAWFALGLKQQENERDDAAIRALARAVQLEPDMRSAYLALAVSYTNEARDELAMSALEKWIELGGGGVNETPGLTVQERQGRIIERLIDIARQRPDDLDPDVQVALGVLFNSSEEYHKAEDCFTAALEARPDDWVLYNRLGATLANSGRSHEAIKFYHRALALHPNFVRAQFNLGISYINLAQYRLAAQCILDAIRLQHADITEGYGEGYGEGVPSVKGVTSDALWSTLRMACLHLQRPDYRGLSSEGEGAAAAASAAAAVTEAMQEHAAAKQAAASAAAAAWDNDGDVNMDGPVYPSPAERAAAAAQRGLEAKRRAARASVAVAHGLSESDDWHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4G2</accession>
    <name>K1V4G2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP12-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4G2"/>
    <dbReference type="FunCoup" id="K1V4G2">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V4G2"/>
    <dbReference type="eggNOG" id="KOG3015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047893_1_0_1"/>
    <dbReference type="InParanoid" id="K1V4G2"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26672" checksum="506D30FBBB4F3835" modified="2012-11-28" version="1">MASLSRSLLRQAVAGPARLAAPRVRLSARALSTTPAFRAENTPGPAVTPTNRITVTLDHRNLKTPEGAKMVIPKERQLLAMMIAAEWENQDQVLKQYALPLLTTSYPDDHPAALVRLQEEHWAPLVKWLKDEYGITLKEAEGFGVAEQTPETIAKFRNILEDMDPFQLAAMERAVYATKSFVIGLALVEGRITAHEAALASHVEVASQIERWGEVEDSHDVDYQDIRRALGSAAVALHKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V527</accession>
    <name>K1V527_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_06620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V527"/>
    <dbReference type="FunCoup" id="K1V527">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V527"/>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045153_1_0_1"/>
    <dbReference type="InParanoid" id="K1V527"/>
    <dbReference type="OMA" id="PECEAHY"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000270">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC99079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="28354" checksum="64914457B019ADBC" modified="2012-11-28" version="1">MEGLSTFLEEASTLLEPFGMRIKRAKSDDGVGWVVLANDETGDIGRMATDLSSLEISYFRALLEAIMLSHPANSVSNAQALRLTTDLKGNMSKRDAETLLGALTSRGWLAKSKRGRYTLAPRAMIELDSYLREQYEDEGVICANPECEAHYHTYCYEQIKQAGRDKCAACQTRFSENEPRPLGELSVPRREDQWGTLNNRRKRRERDDEDEIEDEEEEQELDSEEEVEVSTRSVVSGPVSTPATTSNVALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7W2</accession>
    <name>K1V7W2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7W2"/>
    <dbReference type="HOGENOM" id="CLU_877694_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7W2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="33982" checksum="852965F77E28F1AF" modified="2012-11-28" version="1">MEDHQSGGVDHPSYVLGKVTGCEAQVLGMMDDGGTIHEPHRGLVKERKGEEDEEQESQGPTSTPEKPGAVHTTVQGTTPFEHDVRHKQGQHPCTKVQRQKEHEELLSAECLGHVHTETESIAVVEIEAQKSRNASDANEECMQAVLERFGIREIGQSPPRRETAPAKGGQEEDEGIGLVAGGATGIRSDTQESNSSLNIGCSSDQKAGDAEGQNDEVHLERPGIEVDDAGWNVGGGGRSYPDSEALEKCAAGKLEHCGFLEMGGGGCDEEGGGGCDEEGEEERGRGGVRCVLCQRWDCALRGQSNRSILPMRPLQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8I4</accession>
    <name>K1V8I4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside-diphosphate-sugar epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8I4"/>
    <dbReference type="STRING" id="1220162.K1V8I4"/>
    <dbReference type="HOGENOM" id="CLU_306989_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8I4"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="645"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="926"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="946"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="964" mass="105588" checksum="C7847190C3C74A69" modified="2012-11-28" version="1">MTSSGTCTIRVGQGLIEGGVEHVRVGKDVPGEKFRGKHPGLSFFGRYRSPGPALSCSALRALSDKGAGIVEVQEDAADESGEDEAHERNLVGPFVDLWTFDLEHKLLALALLFLLRYLRTCTPTLNVGESAQVCKLLSLTGPSQVERVPEIGEDPPVDLLQSLDVRWKGYAAESWWTMQGRVVVSQYAPEHYALLCIVGGGGRAKYDPVVENEVTRLVVLANKAALIALKCTEEHARAHGRPRHHDLATFTKLRDEVEVKIREVGLENELDDARYKLAIKAAWFSSRRVAASYSRSRARDAKSSGHDSLGTRFSAEREQQFVALLREDEERQRRGVTPRVARNPLRPLFCSSNEKWKQYHLAQPEGIDIIRSAAKARVPRTNFRRSTVPWEVHDDPAVRVREQATEDSVVPNGFDVVSCDTCMETVIPIPDADGYAQSRRHACSADLAPGAENVTVVEHLRDGCTRSRIHFVSELLAFPELLEQAAQGLEEHDFADVVRRILDETVDNPLAVPSTGSGGGGGQRTTSAGRAGGTASLSFSKSPAGAVRSTFTGVGAGPKPEKRQLMCAAPMSTATRANHAKLAHHARRPDLAMCCWGKRLKDDQDASFPQPATPTMADTTTTTTTTTTTAPAATTGASPTTSTGEKNIVVFGGTGAQGSAFIRALSEYPGYKIFLLVRSEKPTPLKDLPGVTVVHSAEYGEHPALALRATHLKPGEVYGVFSVQGYIPEKQEITQGKNIARAAKEWQCHHFIYASANCRSEEVNDGMHGKRVVEAEIEKQGFPLVTILGDTDFMDNWLPHASYSHKLYRTVLWRKTFTPEQLGTKKIMLISTRDIGRAGAKALNEGITGKIPLAGDKLTMNGIIETYEDCYGKKPDEAMGLAASAVKYVSSAISGLSNFYKNFDSEFDLEVTRKLLPDPEDFKSFLQRTKEEQPTRRLSFTGAHRKSFDKSAERKASKDSAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB76</accession>
    <name>K1VB76_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB76"/>
    <dbReference type="HOGENOM" id="CLU_1230674_0_0_1"/>
    <dbReference type="InParanoid" id="K1VB76"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="225" mass="24696" checksum="1F739DE7BBA35472" modified="2012-11-28" version="1">MKSTSVFTAFKSPFVLHTPSSIEGAYTVQLSDASSGQPDVSLKSAKGKIDADLSLLGKRPASIEADTRNHPLRLRVSAQNPIDVQASSGSGEFWRKDRLTSGAIHIWLPQHFDGELIAQCFGGLRAELSPRLASYAVSLPGKRDDYEWNAPEYRQSWRVRLPPDPDVEQGQCQASGTLLVGTRTDEEELQAGSSLIKATTVTGRIYFYHPSDDVISERSDRCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBI5</accession>
    <name>K1VBI5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000397">
        <property type="protein sequence ID" value="EKC98130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBI5"/>
    <dbReference type="STRING" id="1220162.K1VBI5"/>
    <dbReference type="HOGENOM" id="CLU_426536_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBI5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="642" mass="67960" checksum="39075A4AD41121D4" modified="2012-11-28" version="1">MPPVWVPRKEQPSNASEIRDSVVNNREDVVSEVLSHLSSGDLATCMRVCRLWYNEAARFLYRSVKLDHETMSSFLYGISPLCDDVEPCSATMTEGIWKDCDHDTAERLAITSRPRTFYNFKAPLLRYVQSLTLCSHHRCACAPSGPLIHRLLCNLKLLRVVRSVCGCPSSCAINALCDSAACPFLNCLADKYVFRNNDGDCGAAASSRLDRHGFLYDVEGRDNRTTVVLPRTLGLLHSHGSADIAFGSALNRATSLKIVFADWEGCRSRPSAMTITIKDARVLLSTLADLLRSAPRCHEIVICGLERLELAETRGGEAAQIDADDLRSLKKLIEDHIRKAVWVQPVLPDSMVHSHDPHTGDIVLSFGSIPHHGGGNSNQSAMQGGGDMNDALPGAGIPNPAALFDSDVDMSHASENDGSSEHSDASAKTEDDSNSDSDYESANGEDSGEETDLEDDGDGDAEDEDEDEDEGDGGESDAHTGEVEDEEDMELEAASQELLAALASGFIFGIPLPPAGGPSTQGNATNGAGAATTTTASTSPPAAADAASEAAPASASDSSASNNSATNSGAGNAGNTSAPTHTANGATGANATHGPVNGQSLLAAFQEFVTSLTRTKPLDGQVVFQTFDEYLADDDSRGELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBW9</accession>
    <name>K1VBW9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBW9"/>
    <dbReference type="STRING" id="1220162.K1VBW9"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_4_0_1"/>
    <dbReference type="InParanoid" id="K1VBW9"/>
    <dbReference type="OMA" id="EPIAGYC"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06154">
        <property type="entry name" value="YjgF_YER057c_UK114_like_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="476" mass="51221" checksum="5EE955F3D5375271" modified="2012-11-28" version="1">MPNNEIETTTIGDGANALTVPRLLTGLWQLAGVEADDGKLKELASGLQPYVNSGLAAFDMADRPGRMQGGHRPGVQAYEHQVHRPHAVPYLALRRHRLHNLYELTKMQKEGRIKNLGLTNVNLAHLRLLHSTGFKLVTNQLSMSVLDRRAELGGMAEWCAKNGVKLLAYGTLLGGFLSEGWVGKPEPSAKELGTMSLQKYKRFIDVAVGGWDAFQKVLAACAEVAKKHNVAIPAVATRYVLQQQAVGCVIVGSRLDNSVAQKYIDRNKAVFSFELDDADMRTIREAQKALKPIPNDCGDEYRVPPFLTASGDLGDHLDPAAEREQLATVERIANAGGRVQVSGGSKYEPIAGYCRAVRVGKKISVSGTTTLSHPSGTGVIGGKSTGDQATFILDIISGAVRALGGSMADVVRTRVMLTDVKNWEPVCKVHAAAFKPFDVRPSNTMVGGIDLIGDGLLVEIEADAELGGQKTDVLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC60</accession>
    <name>K1VC60_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC60"/>
    <dbReference type="HOGENOM" id="CLU_1541197_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC60"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="174" mass="19223" checksum="2AEF9ECA491A9832" modified="2012-11-28" version="1">MVDGHRARQPQSKPCDQVRRQASYTQRNLFLVVPSFLSSPIATTPTLTLVPPSASSFFENLGKLLDPPPLVSPSPSGSDSERSPHAHRKRAHASGRSLPLFIPFRPPSRPPGTRPEPPSTDREERENATAGDCRALTFERETAARAPLRATTLDHSKERRSVHAHAHAFWSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCV6</accession>
    <name>K1VCV6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCV6"/>
    <dbReference type="STRING" id="1220162.K1VCV6"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008226_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCV6"/>
    <dbReference type="OrthoDB" id="10690905at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="837" mass="92791" checksum="3B27449FEA9F9410" modified="2012-11-28" version="1">MSCTAQRYVEGEFARDLWAQAISDIQRRDSATAAPGRSISLAEASTFSDVVPKSSTTTAEAVVDSILEWLAGGPPLSELDNTCLLDVKKVSAVRQKYENPRNRRYAMRESLDLRRQVFLEDDGALAAAAYHKLGEVEIVPTWARRQCPQAAPGRRLRRSHGLYEAGSLTVNEKLEAISLEEACEELYANPGPEHPLLRSKPEESRSIVDLIDQYDPAPGEDDAVLELLEYSDTFLKIVEEFESVSFVRKTLTDRKLKGKSVPRNNAGFPVVFWPEAEEEDVWRLAVRVLCRAEEDCDHVFPPSDSNGPAGVLFLWVSHWISHGTRSILSGIEIDFIPPRHGLRRPTLLAHKAHHAPFNLGFACAMPTSLDDYDESKVNARVELWLENRLVCSWRLPVLVSMLRSAGLPEETTERPSTAYTVVGLRHLLKAKGAPSEGPKAELSRKLAEFQDGPDLDLVEPSSSLDFIELMETYSRRAVRRAGAPSGGCQGPAVFRRRGSRSEFFSRAWARYVVRDDWATGDAGCAEEHRGRFAKTRQQVHARLSLVVFDEAGCVTEPDPLGVLQLLAALFVLIGDHQQLPPLVTSRTAVGVGYQRSTFQRLIERGSYLIFLNESAYHGRLLSADLQWLDPRKTAVRHRHWALGPVSFVMTQSHHEKLIVALDAITSAFDLLAPVSVQIISAYRSQLQCVKDKLSPRFLRGPEGWLVGSLVVNVSTDDSFQGQEADAVVVSTTRHSTPTSSPGFLDDLARANVALSRARKSLVILGDPVILRRLPAWSTALHSAEGYGRLGSPSQVQATSAVSWGAVAQQAMCWTRFGWQEGAFSGRNGWGFDGMQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEW5</accession>
    <name>K1VEW5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">A1Q2_08124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEW5"/>
    <dbReference type="FunCoup" id="K1VEW5">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEW5"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="InParanoid" id="K1VEW5"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="31497" checksum="3F164EF9EC6EE50E" modified="2012-11-28" version="1">MSNLPAALNATEDDIQLLLAAQAHLGTKNCDKSMESYVWKRRADGIHVLNIGKTWEKLVFAARILAAIENPNDICVISARPYGHRATLKFASFTGAQAIAGRFTPGSFTNYITRSFKEPRIIVVTDPRVDHQAIREAAYVNIPVIAFADTDASLKFCDVAIPCNNKSRHSIGLMWYLLCREVLRLRGQVPRGPTGPSGWDVLPDLFFYRDPEEIEREQQEKAQQEAEAAEEAAAPAATNEEWTGATGTDAAFAAQPTDQALDWSAEPQGGDWAAEPAQPAQDGATGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF96</accession>
    <name>K1VF96_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF96"/>
    <dbReference type="STRING" id="1220162.K1VF96"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714079_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF96"/>
    <dbReference type="OMA" id="HIVMTHR"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="387" mass="41793" checksum="E8873B43335CD824" modified="2012-11-28" version="1">MGGPGKLADLGNVTEGTNSYLLQAAAGSPAILVDTTQPNTADEYTRVLMEHLEKKGRPPVEHIVMTHRHIDHIGGIAPVLRALQAQGYPKPKVWKMVSPDEAKLQANARDSIHTDKTLIDSVKACEGAYQPTESGEQVWELNGGDRISVTSGDKKLDAVVVPTPGHTADSISILIEPSDGQDGPTVLTGDTVLGQGTTIFTDFAAYMKSLKTLYDLKPSVLYPAHGPAIVGRQECDDHLAAYIKHRQDREDTIVEEFKKIAANPGIIGKQLDEIRHAEAEKHKPEGDPTAPAAPLAKASLAEVPDFAALFPGPNDEGASAVTLPLLCRLIYKSGHQPLIMAAMRTITAHIEKLEGEGRVKKVTVPLPRIMGWTVEGTEPTEAYEWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFD8</accession>
    <name>K1VFD8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFD8"/>
    <dbReference type="STRING" id="1220162.K1VFD8"/>
    <dbReference type="eggNOG" id="ENOG502S64Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973819_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFD8"/>
    <dbReference type="OMA" id="WAGQSCE"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853741" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="30913" checksum="B7B318D534B27AEE" modified="2012-11-28" version="1">MRLSLLLLAPLALAQQAQVYLYPPPSDSSSSPSLTAEQAEVVIAHHLGDGIENRPTPQDEGLWGHLLNVWQHEKRPRVVIVEVVLPDDAKPAFTMETSTASSVLAPYVDAARDALAKVADIPEVSKVLTSLDFAVSRAGSILSHELASLVALADSMWAATERNWDAVRVHLDVEKGSELWETATSGVRAGVKAMTMDDASPLVLVVMPKESSQDIETSPWKRDTLAELLKKKEKVVPKDYSVHFSLFFGTIILLAVAAIGGIQLLASVGETELPSTLTLAVSRKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFI3</accession>
    <name>K1VFI3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFI3"/>
    <dbReference type="HOGENOM" id="CLU_2110665_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFI3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="115" mass="12620" checksum="051BD596CD9DA645" modified="2012-11-28" version="1">MSSPRTSVFQHRYAPPLNLGATFSSGLRDMRHPLCMRAVFWNSGASGDTSGNPIVPALPPHLHSTAAMPEPTPDYGTQLRRQGVRHTRHARHSRPEHSSLGSQPVNNHEASHDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG46</accession>
    <name>K1VG46_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_05916</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG46"/>
    <dbReference type="FunCoup" id="K1VG46">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG46"/>
    <dbReference type="eggNOG" id="ENOG502QQBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_1_2_1"/>
    <dbReference type="InParanoid" id="K1VG46"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="59"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="250"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKC99770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="402" mass="44456" checksum="D08BC6A4197BA315" modified="2012-11-28" version="1">MSLRTQALRAAVRANVPRASRSFSLLARQAPKAAVAAASRMGLTSQATRGVKTLDFAGTKEDVYERADWPVERLQDYFKNDTLAMIGYGSQGHGQSLNARDNGLNVIIGVRKGGESWKQAQEDGWVPGETLFDIPEAIEKGTIIMNLLSDAAQSSTWPEIAPLITKGKTLYFSHGFSVVYKDDTHVVPPKDVDVILAAPKGSGRTVRTLFLEGRGINSSIAVYQDVTGHAKEKAVALAIGIGSGYVYETTFEKEVYSDLYGERGVLMGGIQGMFLAQYEVLRKNGHSPSEAFNETVEEATQSLFPLIGKYGMDYMYNACSTTARRGALDWAPKFKEANLPVFEALYKSVRDGSETRRSLEFNSRKTYREDLQKELDEIDNQEIWRAGKTVRALRPDAKKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGB3</accession>
    <name>K1VGB3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGB3"/>
    <dbReference type="eggNOG" id="ENOG502RB8B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839425_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGB3"/>
    <dbReference type="OrthoDB" id="2447764at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="315" mass="35919" checksum="AAD2649A83B050E7" modified="2012-11-28" version="1">MMNLASSGGKVFEVAEILARSLEQEPNEQGRPEYFYIVRWDGYGPRDDTWEPRSNVMVGSSRLVQEFDAKLKLLGWREGDKGPEHLVRFGQNRPRLQPSPLYEEVWLTRAGMRAHNVSRDVLDKAKKREETGEGRVKREIPKKEEDEGIEVEVEAEDVQPDALQEVEEKAKAEDAKDDEYAEGAGENGDEADDAYDAASNHSNEGVEIIGLRRDKYQKKGIHRKRNVYLVRLGYDGMIEEEAWYTAAELNRRIGRSCQRIVEAYLAAARKPVQGKFVYWVKANCDAGDENDYEVERLKQIAENKALLEQLGLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGG6</accession>
    <name>K1VGG6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGG6"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227519_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGG6"/>
    <dbReference type="OMA" id="GHALHEC"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="104"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="201"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="2200"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="734"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="839"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1385"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1461"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2034"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2131"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2327"/>
            <end position="2362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2627"/>
            <end position="2676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="886"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1262"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1408"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1461"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1497"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1564"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1639"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1670"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1684"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1712"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1756"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1805"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1882"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2651"/>
            <end position="2664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2896" mass="305816" checksum="88070E326D10315D" modified="2012-11-28" version="1">MADAKAKEKPIASLIAGASAGGVEAFITYPLENLKTQLQFGGHNGQVSLVGLLRDTLKNHGLRGLYAGVPAVVIGNAAKAGVRFTTYDQFKGLLKDDEGKLTAPRSMLAGLGAGMMEAIIAVTPSETIKTKMIEDAQRAQPRFNGMLDGVKKIVAEEGWRGIYRGVGPVMLRQGANSAVRFSSYSTLKQLAQGSMPAGEKMPGWMTFGIGSTAGVITVYTTMPFDVVKTRMQSLEARTQYRNALHCAYRILTEEGILKFWKGTTMTCAENNPTVATIDDWVEVSFEERLECPRKPRRNPSLPALNLVTVQQPDEPEQVVDLLESPERRTYTFGRFEETPWPHSPSGSVASLAMASSTGLYIELDRHMPSLLPCANPPSWPSWPSQPNRPAKAGLDTSSGQKSLDLPSLSLSLPQSTGDGYDSDGSSWSELTETGQWAVCAVSLASSPGPGLAQLAPETPPEACFPTTPSTPLALPSRPHSPVSSISDSDSSSEDAFDPMLGLLALASSTDLTDPKRLSFRSQRKQREGAVVGSLSLGGGRGGGGTNNGASWACRDNAASDSRGRPDLSYAGLGGADGAIGANGAGPHRLTEFGVAGVGLAGTYAAYGARRSSAIPPMQPAVASAERRRRSLPTLVLQTSSCTSLLLDHTLTPVFDSDSDTESEGEDLLAQIPFDLSPLRSVDLRVCVDQTGSPCPAPASPAHLALTPAQTTPVTPAPAAAPASVISAVRTDRAARTVSSISTTSTGGGRVTRPPNRRAATSPAEHDYSYSSSRDIRGGLGGMMKGDPNSTRIDSLFPPSSSSSHSKHGHGLGLGGLGGLGGRRGRGPLSLFGLRRSLSVGHRSEASSSVGAKSSSPNSSSRDGDAPEGTEGTEADRGPEHIYPGISARSGSLSAHSAHSAHTTHSASDSARSSFDHHHNGYGATGQAGRGDSAYATVGGLATPTPGERKLPAVPLPVTPTSAHGPHSPALSSPASPYCNASQASYATDPYPSSPLRFQRYHYLPSSSRASIASSPRSPSFPHHPHHVYDQLLNASDAASPGSTSASASPDPSSWHEHGAHGSGSGSGYPGAGATAGQVGPVLDAGHSGHSGHAGQQAGQKTAGDLGEAQPVTGSRWPVYIHESEGDDCGECIFGHDGSEGPDAGDEVLSMLLATRGSRGGDNTRKGDREPTIQGLTGAMDGDASEGGQGRNAIHASRSVHPGTGPWESDHLGFIDARSDLGDLGGVHTATRIPPSSSNAELDRTTEQPTAAGNPTKPPPAPSLSHPAAYAAIPKDDDSPTLEPLSLPPNDHHSYHSSCDLLPLTSDPVQDHQDPLDPLSSTQPLHLQLQSLTLPSLDFSAPPTLPPAAPASPTAAQVTAFAYHTYPTDAQTRQTTAVALHPLPDSKDAITLKSPPPPPIESPDPPSPDQHDQHDHQDPESCDPPNPPIPLDKHTKTTSVPSVTAVGPPVLAVAPGLPIDVHDKVESTPSHPKMERWNPHLYSPRMFPPEHGHGHPTYVSNGTGNNSLGRKTSPRPSPLPSPAPSQGLSHDGSPLSPTTTSSASIHDTKSIKEKPKKKGGWFGRKNKDDDETPAKPVEKKKKKKPAYSGGGYLDSLMLPPGQPLNQTVHPPGGGRAATKSPRRKPSSVEPMSPTWSHSQPDSDRARSVRRPSSKDADNNGIVVEIDARSSPPTPHHIPLPPLTPQSTSGQTSAQRLASQNRPPLPTQPHTPNTLPLSLSPRSSTLRLDPLPAHLQHGSESSSSGSVANKEVDKRRLSQYTISSFSGSEYSQSLPSATMQRSTSGPSGLYPVGERGTVSTVFEEEYPQQTQTNGRQAAQQSDRRPSTIDSDDGWARDSQGGHGGLGHSQNHYRERPSALQLQHTTLPARRQYTPSPGLPTVSLSPRTQRSSTISSTNSATSKPKTPASHPFASGRAPSPNHPADYLTPPAGSPPAVPSHAFPSPNDSFKMPAPAVPAHQVALASPEDEQGDPDCPVCCESMSFTFRLPGEKPHVVPECGHALHECFVTVYGPVPPEGSQKNIGVCGVCRQPMRVNGNDRSSGKNKLATLMGGSESASSGYEIVDPQSDDPLEPAPSPTSAVSGRAGPAEAPPLQVVVPRIEVRPEFQSVRRSKTGKQNVTALVVVEVPPAADRSKYPARQRRTSAADSYANLPPSPSSSGSFRESVMSGLQAQKTPFANVLADLKRRLVAYKYSGLESVGALCLFDILKVRKASNVQDFHLYLFQDALICVSEERKSGITGGIFKKSQPESPNESVLRMRGRIFLRDVHQVTDSSTVSELSIALTLETQEHGVDSIVICFSDRNSHEMWRSTIRRLIDDAQVASGTNGNKIEKLLGSGGPPQRPPSRAHSTTSSGGGHSARPSAVVQGSTMNLFSDASEACTPSCPTPCPGALAFNVPIAPHHTPIDIVLAIATPALAPGATLPLKTRLMRTALHFVLATMGPRDRVSIVAAELGPNAVRLEAFVEGIGAGGQGDEFEIETQEEKPDVVTAVNVALDVILQRRQMDLVTARLDAAKIPVHCFGYGKAHDPSPLWMISNHTHGTYTFVKEWYHLRDALAGVIGGLMSIALTKVGLRLACQDDDFRVVKVSGASQAVISSSGRDIDIDLNILRHGEVREILIDFELESDPVPGTPFGSATPIDSEGDEGGPTRPLSRQQSTSTASNRRPSLARAYSGGSVGMNGNGLGELAAREAQREASGSYDDNGMEEVPVVEVDCTFHDPLAGRSAARMMNPLLLTLALLPPSSNPSSSAADSVIVRRRMELLASDMITRALLAGSRKNFGQATRILRETKRILETKSDHLRASVSSSPHRSRRDVATLAAIDGLSATIQDVDMILDGIETNQDMFEADYRNYAAQQTVILRTQRSWTIRTPTEVAYATPDVQALIAGSGEYAPRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGK2</accession>
    <name>K1VGK2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGK2"/>
    <dbReference type="STRING" id="1220162.K1VGK2"/>
    <dbReference type="eggNOG" id="ENOG502S5FF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342302_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGK2"/>
    <dbReference type="OMA" id="WQDQLLD"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="182"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="828" mass="91126" checksum="3F4F29968BDB15F1" modified="2012-11-28" version="1">MVSILSFFNKKRPKTEDAPGRPVSPSRKASQRKPKSSPTGRGRSSTEGAAGGGRRKGANGIAASTVAPPRLDIPLPFEARASELEHDFGLEGVVKNPKLNSTERKALDAQRYTPTDLKSAWEWIGPELAARGAETTGIMLPRRWNANKDRQRHLTTLFVLARRPELADKFPSVTSYVPKTDNGDDWKARLIAYARDSDPVDLAEVLKLVLRRLAPQERPIIDPDVYVKFVQSEHAASYPRRAYADMLLPKLSEETGEVLHAVFEVCNSIALYAETNAMTAGRLCHLFGWWLLGEKPDGVTNWSDLYDGYKLAGQRAEHLFYAHLRWQTKQQKMPRRLVQLIINYPFGESSASSEHLPLPPASTFSRKVLHVALGTDASVPRGSDPERVANEALVAKADDEVTAPEWEDVSKPDGKTVTLDDILAEGSRAFIEEFLQTKNIDILSPPTSPRLSPEPDHASRRRSQSHGDIPRLGSASSSSPGSPTKLSPGNAGPTGWSDFEKMGFSDTSDNVKGISLSLIQPTASTSTPRPKPKRTVTTSTEPKITYLIAAEEIIELDDAFIQFVEDGQLDLSASSTWPRFALLQLKKPTNSSTAEEPINWVLVTVQKRIPRVTAPDDDPFDINTTALDRSVSPGRESSVSRLSSTFGLKDFATNWRSSGMFHSKSSRKSFLGSTRSSRGGDSIRGNESIRSSSHYDGSTNNVSTLPVVNEGDKNKLSTSSEAPTEYTILLVTRQALGRGLDIRLLCLNRVGRLLGIRLGESSLAKVVDNLERCLAVDLATLLFIDIPPGSTHDTSFLYSPAHRYPPHLHAFSSSLTPSYYYILIHKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH97</accession>
    <name>K1VH97_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mog1p/PsbP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH97"/>
    <dbReference type="STRING" id="1220162.K1VH97"/>
    <dbReference type="eggNOG" id="KOG3329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081345_1_2_1"/>
    <dbReference type="InParanoid" id="K1VH97"/>
    <dbReference type="OMA" id="PDEVWIG"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23122" checksum="C09E14462FA57DD3" modified="2012-11-28" version="1">MADVQTTTRPLFGGAISFDVPKDYIDASDLRQVPDNQEVFLSNDSDTAIIFEILGAVQDGGAASDMYEAANVAHDNAALSATLTTPPPPTHVVPAQTQHVQSASELQTPHPTVVTGIQKVHKFSHDPSGAPRRGHENDAPDEVWIGLALWRIDVDIAGHKKKADIVCTANVPLKEAAEGNPNGVTSEELAKVEGWWRNAVAGMKINDWNLFGDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHL0</accession>
    <name>K1VHL0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MBF1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHL0"/>
    <dbReference type="FunCoup" id="K1VHL0">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHL0"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112609_0_1_1"/>
    <dbReference type="InParanoid" id="K1VHL0"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="152" mass="15739" checksum="30F754B161A7A34D" modified="2012-11-28" version="1">MSGWDEKPTVIGFGTKRPTVAKGSALNAAQRAGTVTSTTAKGRAQGGGATNYQKLGKLDADDAPKPPEKVDISVGKALATARMAKKNADGKSMTQKELATAANAKPQDIADLESGRALPNQQLLGKLERIVGVKLRGAASQIGQPLHGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI18</accession>
    <name>K1VI18_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI18"/>
    <dbReference type="STRING" id="1220162.K1VI18"/>
    <dbReference type="eggNOG" id="ENOG502QPS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009630_3_0_1"/>
    <dbReference type="InParanoid" id="K1VI18"/>
    <dbReference type="OMA" id="MNQRMLK"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851880" evidence="2">
        <location>
            <begin position="23"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="136"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="483"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="621" mass="66938" checksum="A196823147929077" modified="2012-11-28" version="1">MKTPSSMVGSALLLALAGQVSAQQAAGSFKVVADTLASAMMLFLGPANKLYVLDKTERNPTMAPGKNHPAWASVIDLDTFESVPLDVRTNTFCAGGTVLGNGTWLNAGGNKAVREGGQDAGPLGSAARVDGDNVYGNVDGGKAVRVLDCDNAGECTWYDNARNYMKFERWYPTLETLEDGSAMIMAGCIDGGYVNDRNQDNPTIEYFPKHTPQNANWFGVDQELIELQILDRTLPLNLYPLIWLLPSGNVFIQVGLEAEIFDYKRGIEMPIGNIHGGVRVYPASAGTVTFPQTPANNWTLTILFCGGTDKDGSAQTWTAQNPEPIVNWATSQSCVKISPDVDVNWVDDDNLPGGRSMGQFVNLPDGRFLFLNGAGRGTAGYGNGSDWTVGQAYADDPQQTAYYFDPRAPAGARFQEAGASPIPRMYHSTATLLPDGSVAVAGSNPNADYVDPNNFPNDPHPTYKYGTEMRMEIFYPDYMDKARPEPKNLPEQITYGGPYFNVSLTKADLGGKTLNINATRAVIIRTGFSTHAMNMGQRHVELATSFTTTPDGDATLHVAQMPPNPAILAPGPALLFIVVDGVPSKGSYVMIGDGIIGNHQIQPESVLPQSSISYDQWHMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VII8</accession>
    <name>K1VII8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromosome organization and biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VII8">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VII8"/>
    <dbReference type="eggNOG" id="KOG0389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_16_1_1"/>
    <dbReference type="InParanoid" id="K1VII8"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000102">
        <property type="entry name" value="Chromosome organization and biogenesis-related protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="495"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="880"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1255"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1489" mass="162860" checksum="17F8D17ABBDD47C4" modified="2012-11-28" version="1">MTAAEEKRRDALDKLKRRAAGSTPGGPTRPIVIDSATPSPDPARVLVPASSSPVHSPAAQGMGRTQIPSSNLGRLVTSPVKKSLGEYSPSSPQPLSRLKRRADPDASPTKAAPASLPASASTSRSTSATASRSASATASASKPALPRKGPPKLVAAARDQHNADVEARIQKLIGQYPKANRAEVHQAIQRNPNNPEEILDQVREAHERGITTERQAQNSAVVSSKLKTFTYVPTPSPSTPSSSQPASPFVSSASARPRVSTTIESPKKKRRNENSTIYAKRAKGDKPKRDADEESAAESGAESDGSDAWSGEDTRVRKKKRTIEDDDDEIDAEGAALRGFNEDSVETLTGTIACSEEQANKIISLRPYADADEVAAKLRKARGVSFKLFEQYVDIMEGYVQIDSCLNRCESIADEIANTLSVWKGASTASDSVTGTPSNLNDVKVDVAKVSELLLSETNTHKRKILASYIRQQPSLLSDGTVLKDYQLLGVNWLNLLYSRKIGCILADEMGLGKTIQVIAFLAHLKERGIHGPHMIFVPASTLENWTREFERFAPDINVDTYYGSQAERVELRSELKHKFRAGKLEVVLASYTQVTSHDDLSFFKKKIDFKTCVYDEAHMLKNFVSKRYTDLLSIKPQWRLLLTGTPVQNNLQELVSLLMFIHRSVFAEAEPHLRAIFKVQSGGGGAAGAKASMLSQNRVSRARTMLTPFVLRRRKAHVLTLPPKIETTEECEMTPTQAKLYRDTLLRSRKAIASMSEEALEAAADGDVDEDGKPKATKGKKKAASAPKDQSSSNILMELRKAASHPLLFRRIYTMPKLKQIARACLNTPTWCDSNFDYVVEDLEVMTDAEIHNFVKEHEELAHFALDEKEFLEGGKMAALLRIIERCEAEGKRLLLFSQFTMILNILEVALTSKGVKYVRLDGQTRTDERQGIVDEFNEDPSIPVFLLSTKAGGVGINLTAASVVVIFDQDFNPHNDKQAADRAYRIGQERPVEVIKLLSKGSIDEDIAAIGQTKLQLDDMVGGDGVATGAGTPATDASEDKTAAEVKKSLLKTLRTKFEAEGDAAGAEGTPEVEMDEDVVEWRHDVEVDQKLPIYVDSSERLWTSTTDRQDSKMYWYLSFLRPPPVATPLGEPVVITPQVANDLRTELRESPTEVLYTWHRLHPPSQPLPSQVLTTFEPPMSTYKPISVPLPKGAKVGELWRLGLLAPPAQGPSSIPLERLLADPGVLGVWSEGIELLPAAAPDPKAAKGKGKKGDKGDKGKGKAKEAPKQSRITRSWPTAYGALKVVEQTSFDLDKVSFGRSSTADEQKVWDSGLALSAWLGRYLSTSHPHTLARRVLDLIPGNSILELGSGTGLVSIALSPLAPSARITATDLDLNGVDVAAKVLDWDAPMPPWVESDWPSLVFAADVTYNTASFPCLVATLERLLKPKDRPAPLLLLAYKQRDEAERDLWAMLNDRGIDTVLVDRVQGAEKTGETEIWVAGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJC6</accession>
    <name>K1VJC6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJC6"/>
    <dbReference type="STRING" id="1220162.K1VJC6"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="K1VJC6"/>
    <dbReference type="OMA" id="HNDPDQV"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="304" mass="31793" checksum="F48A34532E8FE416" modified="2012-11-28" version="1">MNDPVSFNINDLYNVEGLTVVITGGGTGLGKAVAQAYAQNGAKVFISGRRKEVLDKAVQEIKAAGGKTDVVPIQGDVSSKAGCKALYDAVAKQTDVVDVLVNCAGVMRQYKNPTTDHDNIDAVAKMLWEGHDDDDFNYTNQININGVYFTTVAFIPLLLKSTLRSVVVIASIAGIILQRSVGSVSYSASKAGTLHTANLLAGRLAPGKIRVNTICPGIFPSEMTGTSAKEGGHNYDVSDGAVKAAGRSVVGRPGLPHEIVGPILMLGSRAGGYMDGAMLTVDGGRAMAAGINEGLRIPENLYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJG6</accession>
    <name>K1VJG6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJG6"/>
    <dbReference type="HOGENOM" id="CLU_1741859_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJG6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852167" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="150" mass="14658" checksum="ABFB05F1270183CE" modified="2012-11-28" version="1">MKTSLVLLATVTSVLAQQVPDNLDPCVKNCIAEAAREVHCGQQDLACLCRAAQNPRDDDAIDEFRDCVEDHGDWYSNRHGATGGAGQSPTPSGGNAGAAAGSPTPVGSAAGQASSGVAAAGAAGANDNSGASAVTASSALIIGAIGLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJY1</accession>
    <name>K1VJY1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">A1Q2_06223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJY1"/>
    <dbReference type="FunCoup" id="K1VJY1">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJY1"/>
    <dbReference type="eggNOG" id="KOG0636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJY1"/>
    <dbReference type="OMA" id="MEMRYAG"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="181"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="402"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for oligomerization; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="402"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="578" mass="64048" checksum="F39E7F05974D6544" modified="2012-11-28" version="1">MANTPHGGVLKDLVARDAPRQAELKEEARHLQDIFLTERQLCDLELIMNGGFSPLEGFMNEKDYKSVVDTLRLAPTNGHRQGTLFPMPITLDVSKEDIERLQLAPGVRVALRDFRDEAALAILTIEDIYKPNKSEEAEKVMGADDLAHPAVAYLHNRTKEFYVGGKVEAVQAPAHYDYVGLRYTPAELRAYFHKLAWRKVVAFQTRNPMHRAHRELTVRAARQHKANVLIHPVVGLTKPGDVDHYTRVRAYQALMPSYPEGLAHLALLPLAMRMAGPREAVWHAIIRKNFGASHFIVGRDHAGPGKNSQGKDFYGPYDAQELVAQYKDELHIDMVPFQMMTYLPGSDEYQPVDEVPKGTPTADISGTELRKRLRTGAAIPDWFSYTGVVKVLRDSYPPRPKQGFTVLLTGLHNSGKDTIARALSVTLQQHGGRSVSLLLGDEIRPDLGTSGHSREDKHANMLRIGYVASELTKAGAAVIAAPTAPYDVSRKAFREAVQGPGGNFFLVHVATPLEECEAADRRGLYKRARTGEIKGLTGVDDEYELPQDADIVADLRTDSVPEVVHSILMTLESTGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJZ1</accession>
    <name>K1VJZ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJZ1"/>
    <dbReference type="HOGENOM" id="CLU_698657_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJZ1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="127"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="395" mass="43097" checksum="752D7650272DF138" modified="2012-11-28" version="1">MELQFLLDDGAEELAQSPSPHGRKRKASIVLSSSSCRTRLHQPRTNADADPSSEASSTVSLALAPQAPRALRDSSVWRNTPAGKAHAESYRKVEKLVNNSKAGDDEGPATGGTRANDGAASSNSRARAMTATAPDLLTVPEITINSERDYLVGLGRPLWPLTRSAGDVKDDAEFDETFEEDSETDKTLEEGSYLNETFDEDEVNETYDEEVEFSEAVEEASQSDEDDFGLNGDGTATNEEGPEFEDTFATSEEDSESDAEGSDDITSLHAKIETLWTRLRAAKAEARTFEMTNADLTTRTLRAERRAEEAEERAAALQQHCEELATEVRILNGEVAASAADVGAERSAKAARVRFAKNLHVRMIHSRAECDKPEVPQQALPFVSYMPPEIPTKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK06</accession>
    <name>K1VK06_TRIAC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK06"/>
    <dbReference type="HOGENOM" id="CLU_421614_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK06"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="650" mass="72114" checksum="C366B3DB5D30947A" modified="2012-11-28" version="1">MNRPAFTSSSPRQRLSADVALLRFRSASPRAADQQNKRLPSFFRLNPKAGQQAVDSASPAKRKATPDAIDDVDTKPTKRQLRAASSASSSVGTASNSTTLVDPEADLELDKTTSEDEKGDATRETPTEATEENSNSEHKADRWAAIMRKYNLSDRSPTSGGEQANTLRLQLNTEMANANRYRVLFEEYKETSRHYKEKASKLKLEIAEAKDQLKRAHERASAAELRATNSHQMAMEADDRAAEAEENAACAEAELEHAQCEAEDRIAEVEELLAEAKKAAAEAEAHSGDAKVAARAADKRRSEAEQALSTANEEAELRIAELTERLSESEAVAAAAKARLKAAESYIHGTKQLFDGIGLQHGELYKKYTEEDPELEPLAAGVTVSQAGLSTADRLIYLRGLHHEVEEFIGSVNHQLRETLDCSYSNDDEQYLFPDAYLDNDSDTEDSEDEMCDTSNSDAESEIGLGSEDGTQGSDTDQSDHDDGDDVGEEGDDVGEGGDEEHDEDAKDFVGTEEQAEAGLPADADAENSEDQGPGYEEALAKKEPCEEYSEQEESWLKRMEELVGLRGLHLGDLLLIDRVYRDIPSSEEMDYLEAHLRALDRQAKDLWDEVKHECADIIRAREERKAQERRERKERKRQERRMRQASQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK25</accession>
    <name>K1VK25_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_01166</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK25"/>
    <dbReference type="STRING" id="1220162.K1VK25"/>
    <dbReference type="eggNOG" id="KOG4513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="InParanoid" id="K1VK25"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="17">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="18">
        <location>
            <begin position="86"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD04515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="469" mass="51652" checksum="51C86DFC54CE53C1" modified="2012-11-28" version="1">MSARTAGSPEHDSKKQKTSVKSNVHDGWGLSDEEKGNAIYHGTTTNMDHIRDKHNFAKLDASGLAVGLKEGLMGNSEVGTLSALTSNDDFKNQPAIVDCLKHAKDTNGRLHLMGLLSDGGVHSHINHLIALIRAAKEQGVPHVYIHAFGDGRDTAPKSATKYVKQLQDAIKEIGCGELVTFVGRYYAMDRDKRWDRVKVAVDALVKGDGTKADDPVKAIEDCYAKDETDEFIKPLIFGDDSTRVKDNDTIFTFNYRSDRMREIVSLFAFPDDLPIEVDIPNGLYITTMSRYNPEWTLPVAFPPVSMDNVLAEWLAKEGVSQAHVAETEKYAHVTFFFNGGVEKQYAGEERFMIPSPKVATYDKQPEMSAQGVADKVAELIKEDKFDFVMCNFAPPDMVGHTGVYDAAVKAITATDAAVKTIYDACEEKGYVLCITADHGNAEQMIDLKTGQPHTAHTTKMTGHSLATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK58</accession>
    <name>K1VK58_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK58"/>
    <dbReference type="STRING" id="1220162.K1VK58"/>
    <dbReference type="eggNOG" id="KOG0233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2869245_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK58"/>
    <dbReference type="OMA" id="PYTWASM"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="64" mass="6861" checksum="93E90DF53D20371F" modified="2012-11-28" version="1">MGYTTYGYGTVGLSILTVYGLYLLLTGQGSRFDFGKFLHETSPYAWALVGIALCVGFSVIGAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK96</accession>
    <name>K1VK96_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VK96">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VK96"/>
    <dbReference type="eggNOG" id="KOG0902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000893_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK96"/>
    <dbReference type="OMA" id="MSQRDEN"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1390"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1649"/>
            <end position="1939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1951" mass="216396" checksum="E3F30F80184BDBF3" modified="2012-11-28" version="1">MDFLDEPLDQHILSALAGNIAQSAQSSGAAEQSEYSDDLALILNGLPYTDTDEQDDWTDAEINHAIAFAHYVSSLPSDSPYLASSLPRLRALLTGLIHQGIPTRQDVADNVVNAPGSDNAPGSATNEQALLLMSLLKAVLWIGWSKDAMHQDSLRADVGMGIANLLETAEQIMTSALVFSGAILTCVHQVLSHVPLPPLPTPVTARVVSAVIQLGTPTNLVKAVREAASPNTPAFNHPVFNTAPYPTCPSAVALLVTEIANVVLASAVLPPPQVEHEAFSSEPEATFQEGTVSTVWRNQTKSLLAEPAREIDLDSFPEGQQALDAASELATDWWKELNDHDPSGFTAGTGVVDRRTTMHSSINDIQSEEDVYLTVSVLHLLNLLSLHQNDRLSDQLARLKLILSENSTVSDARVLQAAFVCLAIVVRNLGSSLTHHLRRLFMSPLPGLESELSPSAGEVSPTIAAASTCLAMCIEMSSNDDAISSTLYSLLGVLNHGTTIGPGQNSIRSMPLGGMGGMGDGKSFQSGKRTDEQRKIISTNAVEIVSRLALDTQREDRVRGVDISTESAIVQSLVPLALNANDEDLQEVYRAFSQIARSSNPEDPRLSSNAVLAAQTTLAKGLGSRLQAADGFLQELLTDFADQGTQTQIVYMGAQGHDGRDKDKKTALLRSNNEKRAADMKAQLAALLLPIAEVLSHPDYHPELNPSQECVALFRNFWLLCVVFNLSGSRSQLSEHEASALATIAEKTPVLVLEKANDFVGSELEYNTILRKDFAHSIHSKLRSTLTEVVPSKFQSDIRGMSTPQLAFCLAINDLEEMRTLRYRPSTILQYFCNDSINRSVLVTPLTGIAIRLTNVFLKQLSMQVVEHNMPNTVPEQVCKILIACTHRMRKVREVALAYASSILKTFTALMCDRRVVFTLLEILTLMRRSCEMQYTDELELTDDYSVRNEIVTNLYNVAKMWLTNAISRAPIEVQSMLQSYLNESRDVLLVDSVEMGAGLALHFCKAISRLDRQESLMPMIGGWPSDNSNLVASQFAAKNYYDGELSGARLVLDKEHSRAVSSLEERQAFKQQMEKAILGVNKKGGLSVVEIRRLLLRAVSVLIASPQMDPDILHYLVELPFAAFTPVAVAAGVDAWSWLLRQRPDAEVSLMGEISAGWLATIKAHKGIYTDPFEKPIEYSPTDKRVMDVELRKAERLLKPHLLLIQVLSSSFQAVKYRASGIMISLARMLLRSLNAYEHWSTHPLAREVRFTLLLFGFQVLASSRMETLLELRYRDALFRAAFSWFAIRPQWSFGSNRIQVGAEIKLLQDFIAAVRDDHIRADHWTTSMNDRQPVWTLTGSTSLQDYCNQHRDRVRLMELLVENEINRLNVWVNPGNDKGRSIPNAGGNIEGSVGNDEWTSLVRKAWKQSPAVAVHMGERFKHQPVWAEITRLVRGNPRAVLDVAEAMPYFIGDKLDPAIRGQLKYALIWDALPPVEALNLFQPRYNNNPILLQYAMRVLESYPVDLTFFFVPQVVQGLRHDALGYVERFIFETSHISQLFCHQIIWNMKANTYRDDDGEEPDPMKPQLDRMVDKIVGSLSGKAQVFYEQEFGFFADVTSISGKLKPYIKKTKPEKKAKIDEEMSKIKLEVGVYLPSNPDGVVVDLDRKSGRPLQSHAKAPFMATFKVRKQKIDLESADLEAELDTAMATSSYDVWQSAIFKVGDDCRQDVLALQLIAMFKNVFTQLGLTLYLFPYRVTATAPGCGVIDVVPNATSRDEMGRAQVNDLLEYFIDKYGGPDTVAFQRARLNFIQSMAAYSVACYILQIKDRHNGNIMIDGEGHIVHIDFGFLFDIGPGGIKFEAGSFKLNKEMIALMGGAGSQGYSMFVDLTIKAFLAIRPYVDQLCDTVALMLGTGLPSFKDDGTINRLRDRFAPNLNERAAAEYMMGVINNAYQNKRSDIYDGFQKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKI3</accession>
    <name>K1VKI3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cap3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000217">
        <property type="protein sequence ID" value="EKD04645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKI3"/>
    <dbReference type="HOGENOM" id="CLU_1397229_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKI3"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="195" mass="22150" checksum="128CCC1606E29615" modified="2012-11-28" version="1">MLRSSSFSGNSSSYDEKPLSRRRHSVEEGMLPAQQRRHGLSAMLGVRTRYRIAYAILTACIIYLFVVGIEKQLSPSIPSFESFAGEIPAETERGGTVKARAAHQAAKQAVLGGKRVPLPAEVEGAPAHKVKEGFLRVDPNARVHPIHQLIRDARRKWDTKLAKQSRTLREAVDEYQNRYYQHPPKGFEKWWRYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKP2</accession>
    <name>K1VKP2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKP2"/>
    <dbReference type="FunCoup" id="K1VKP2">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKP2"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_0_1"/>
    <dbReference type="InParanoid" id="K1VKP2"/>
    <dbReference type="OMA" id="MGTAFMP"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="91"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="606" mass="64362" checksum="DA7CF1BBB1499C02" modified="2012-11-28" version="1">MQDEKAPHGRPGYDVVPELSSTQRLDLHPVTTRQSMASQKDVPMAVTAEGVGTTPELALEAGEAADGTRDVEAVVAEPEFPVLSIWRTMAIAMVTTFAMALSGAGNMSLSIALPDIQRDLHVIDSELHWISAAFALTNGCFLLLSGRLADVYGRKTCFVIGVAWYAIWNLVGGFMQNTAAFVVTRALAGMGSALSIPSAIGIIASTFTGRTRASAFACFSAGGPIGGGLGVTIGGLLTAYTEPKWRAALWLFAGMAAGVAIAGYFVVLPDRHLDPDRRIDWVGAGLVTCGLVLLMFGISSAEAAPQGWKTPYIIAVIVVAAFLIACFFGWEHFVETRTSRPPLMRLALWTRSKGKLAATYFIGGISWMGFTTFFYNTTLFFQNVQGASVITAMLRFLPSTISGLICNVVVAKIVHIVPGQLLICFGLAATGVANIFFAISPADEMYWKLPFNAMWLAVLGADFLISVGSIFVSTLALPEEQSVAGALFQTMVQLGGALGLAFVNVVQTSISMKETAKGVDHKTALLHGLHGAFYFAAGASFTAMLIALVMLRGMGAYGAEKKTSINSTDSSASEETRVDRPPETVLVEKVEKAPLETPASELGAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKW4</accession>
    <name>K1VKW4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKW4"/>
    <dbReference type="STRING" id="1220162.K1VKW4"/>
    <dbReference type="eggNOG" id="ENOG502RY79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106400_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKW4"/>
    <dbReference type="OMA" id="FWMPDLS"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23766" checksum="82E8D73C22DEBA2A" modified="2012-11-28" version="1">MPGNRKITLKNIKGRDGVHPGSRKAGQITRAHLRAAKLQKQAKTRKDLKIAKPVFRPTFFHHALSGPQPLSLPSLRALVSDVYLTRNDKRIEELEAERRPGRPKTKEHMELEENRRIEHAEWETGFEVINLTDAPTTRLMWSWLENGTDMQHSHVDLLPFIRIAKDTPDVVVVSKPGKVGNMGLGNGVEGEGEDWTSISKEDQEDEKMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL01</accession>
    <name>K1VL01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000411">
        <property type="protein sequence ID" value="EKC97442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL01"/>
    <dbReference type="FunCoup" id="K1VL01">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VL01"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_1_1"/>
    <dbReference type="InParanoid" id="K1VL01"/>
    <dbReference type="OMA" id="TFCGYFA"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="8"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="240"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="334" mass="35304" checksum="AB14403D9E58C080" modified="2012-11-28" version="1">MSATSACLVAGSVNIDEFYALPHIVRPGETIASTGYSRRGGGKGANQAVAVGRACDNRGAVKLSACIGEDGRDLLDLMVDAGVDVSGVDILKDQHTGRAIIQSSQDGENSIVLFAGANYARSPAPIGSATHVVVQNEIPFDSTLAFLRSAKESNAATIFNPSPMPSNEQLRAFPWETIDWLLLNEGEAGDITRALTSEELKSSVVVPEGMELPAEAKSALDILSGVKSLPLMNTVNLVCTLGAHGVLLFRNDKEWFYRPAAKLLKPLRDTTGAGDCFTGYFTAGLMRIGEPTMEALEGVVDECLAACSMCVEIAGAAESVPARSQVLERMALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLS0</accession>
    <name>K1VLS0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLS0"/>
    <dbReference type="HOGENOM" id="CLU_600185_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLS0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="456" mass="49298" checksum="50825F7ACE78153E" modified="2012-11-28" version="1">MESPQLAAQFNSAPRGRAGGQQPSTMYHDLTRAISDIFGGDDKPQPQPQGPHYTSHSQLSLDPRSQQYASRSQLSLNPGSQYASRSQLSVANDASAPSAFASKTSLAQPGAAYFSGSTTSLNDPSKGYHYKRRQHSDELCTLSKPMTRRSVSDAPYPRPMITASSSYPPPRPTRDTQLSKRPSYPPTSSDASSSPEILTPPNSQSKGRRKMPPIYVASYAEPDPAGADYAQGVYSDPMYAEQQYEEPDQMDPHQAWTNDYTELTDFAQSPTAAMFPKKMSIVEPAPLAPTAEPVIYDKDYAQLERTGIVTPQGPPSALSTSPPSGPSISDPSSGPTRLPPAPGAPATSAPVPKPLRLPQLQSTPKPAPPRSRGPPAIRGPPPPQQASLAHLAAQEKARIAVKLAQQQAAHAKMVSFSDTTPYARQRSQKKSDREAFQAAMRREGSRSARRAWERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM45</accession>
    <name>K1VM45_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM45"/>
    <dbReference type="FunCoup" id="K1VM45">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM45"/>
    <dbReference type="eggNOG" id="KOG0946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006318_1_0_1"/>
    <dbReference type="InParanoid" id="K1VM45"/>
    <dbReference type="OMA" id="GQETFCN"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="414"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="825"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="880"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1028" mass="111306" checksum="58BFF6E6DC7C7A6E" modified="2012-11-28" version="1">MSFFGTRLSSAVTQLRGELSAAPQTANDTITKLVEKIQTSPQVDDRRTAVLGLKGLSRDWKADVGTAAMPSLIAVLRHDAPHDVDIAKAVLETLMQLCETQEKPAKDDVGLKHIDQLLELLTARPAHAQSYVLSAPPPGVDGVLTVLDPSASVGTGTMGGGAGEMLRNEGLLLLPALLQGNSDLQKIVAFSGAFEKTLDIIHSENGIEGGIVVQDALTVIGTLLRFNVSNQNLFRELSLIPQIPPMLHFPSPIGPDEQAPDAFALQDWPEQKMYNAGLVLGLVRMLVGGPGGGNQTAMAKDGVTRCLLELALASNAPNSLKCLALNTLTPIMLGSLANQQLMSSLKVAPLVPVHADDEHPNGGFVRLPLQSTVEALVSSVVEGDPSAGGKALRSRAAGVNMFEVSFRVLGSTNSQAYVSGNDDARIGILESMSAPGAEGGETRTAGSMILNGLLDLPSAETQFDPYRPLFSCLFLSHLIRDSEHAKKLAREISLGGDDEDDKVSLIQLVVGNFMMASRAQAEATSRAIKDGASGHEEEDWTRIMVGYLVLLCTWLWDSPKSVAEFLNESNNLQTLIGPITQSQGIDPLVQGLCAFLLGVCYEFNREPNDVTRATLHPILHSRIGPDQFVSRMARLREDPRFRAVQPDTFEEGAQPPDESAPEPETDEDVELWFDWAFVDFWKNHYYTIQRSIAIEPDAVRGSHQTDGNEDVIISLRQQLKTQTEDNLKYQARLATIKADHAKDLEKLREDQEKEELRKELEVLRHMPPPPSAPDGSAELEQLRADLTSAKAQIATNLQEAAAHAETKAQLAALRDELEEEKKALTEAKERANKAEKAEADAKAAAEAATSKPELKDEGKDKADATELEKVQKELKELKDKLEKAEAAQKKAEAEAKTASEAKSKAEEEAKAASEAQKKAEDEKKKAEEAQKAAEEAAKKADSAGGKGKKGKGGAGGGGGGNAELEAKVKKLEEELSSVKTELEDKEREHEDLLVLLDELSQKRKSDKAAMRERGMDVSEDEDDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM77</accession>
    <name>K1VM77_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM77"/>
    <dbReference type="STRING" id="1220162.K1VM77"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_0_1"/>
    <dbReference type="InParanoid" id="K1VM77"/>
    <dbReference type="OMA" id="PASCITR"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="194"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43014" checksum="CCEEAE4B552BC659" modified="2012-11-28" version="1">MRGCTVYRDGGINIFQRHGHSVVLLPREADMVRIYVPLGTSGEPFDRKSVSCEKLIAILKEWLSPHRVNIDYVDWWTVYEVAQRCTPSMEAHSGRVLIAGDACHTHSPKAGQGMNVSMLDGFNLGWKLAGVLKGTHNPDVVRTYSPERHQVAAQLIAFDKLWSSYFTGQRKVEPGEFERTFRQSMKWMSGTAVLYETGLIVATEDECDPHRANGVSVGSHFENATVKLVFNSMEAQLQTRMRANGRWKVVCDVLQAAIQEELSEYTDGLTNFVKRFTRVGDDLDSVLEVVTVFRSPHSDVQNTTNSFSDVLRPRRTVYGVKQGYTARDTLFTDAEGAAYKQYGVDGPASVLVRPDQHVAGVFEMSEAGLQKMDKFLSRVLVPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMH5</accession>
    <name>K1VMH5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMH5"/>
    <dbReference type="HOGENOM" id="CLU_317169_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMH5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="647"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="919" mass="101571" checksum="E87DF1B6BFAA7CC1" modified="2012-11-28" version="1">MPAAVKRPRPLTSDSEASGHEQRLAPPIDLKPSLRPSLREYRDHVSETDATETETEDAEVELGGMLTSIEQLTDDADVDASLASLPQSPLAAYGKGKGKGVDPAERCLARPNKRSGSLYPAKRAPTTRRRVSPGCSLQPLRPTRRIVSPTESIYNITKCIDSLATSPSSLEDEKRVSSSLLLSPSDANSRSTSSTESLSPVPGSPSPAPDSEPSEDEAERDWLESPLAYKLRQSVHRRRGKLAKRRAAAAITDDRLAKKGKKWHELETPKQRAAPLTVESLESLARQMGYKVVPASPKATSDIPEEPEYVFKIPGPVKEVDTDTTLGSSSKRPLSSPKQVDTLLASAVASSSKTPSPKNKRARRTTDESTSESEKPVSKQAKPAPTKAFALRPPKPSKRRENKRSTVRVVRDRYAGAVPKSKHTVASKAPVHQVGASEAPVQATKAPPVSPGRARFLRRRIRRSHRPVALHRPSERKTLSGFHKVVASPDVAPMAGHEFVHVLQVTVVNRRVRNGMLARHRTRTEQEHTNRVAPPPSRRLSGSPSDEDDEVDLLLESDVEMLDNEEIEVALAQAPSKLNASRKRPPRGGDLAAERRGRRATLRQDEVAVQAERLKAFFADRAAEREAARERRDATKRAAIEWLIAEREREREAAEAVEAARVEAETAAEAEAERQAAAEMQAEAERRVQEEREAAAAEAYEQERLQLQARIRARTARLNLALHRERVPTAGFVAPGRMRAATTPIRTFHEDAAESSTAAEARVEHEIDTLAEVTEASDTEGSEDEDDTPSTPRAPRTASPGPRQEIPMDSPPTYEFPFFPIVRPASRAARPRVLSRQRRASDPPSYVEFRERTDRSPSPPPPYNAQSDRTTLISPVFRSDSESESEDTHEEMHARNDDADVRYQEFRQSRQRSSVSDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMI7</accession>
    <name>K1VMI7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000092">
        <property type="protein sequence ID" value="EKD05405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VMI7">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMI7"/>
    <dbReference type="eggNOG" id="KOG3613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001197_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMI7"/>
    <dbReference type="OMA" id="GLETCIA"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="130"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="307"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD05405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1620" mass="179538" checksum="8FC7150C8C387815" modified="2012-11-28" version="1">MSEQNGSLQPAEAGPSSVASAKAASTPGTRSASPGPAQASSTPSSEPQNKQQLRRPASHGRLSKLMLPGRSRAASLAHDASPVTAYAGDTALASGRTTPEQRRRSARVSQPSIAFWSTHPSPRRLRTCLQHHRVWSSGLFPFFQYAATSVRPALLNLYETYYLPLGEDLRPATKAMILALLPGLEEETGDFFDQVLALLNTLSQAVSQQFFLQNIFLVLISSPASRLAALNYLARQLVEVPEELVTSSDVGLLIRGVAAVLGDQNMLVRRGGLDLLLRILPLDGAIFRRVYTWFLSADESTQNQGEYFKQHGLEPLATTLQAHDVAEAQQPFKTFLSLLDKWEIGQALSTKLAIPVLQIIYQAATGPEGKDVRSTVTAVYDDIEPSVLWKQLHDAVNRDLENDSTEHLVLIDWLLNAVTKSDHEVLTIHAPLLLFTILQRLPALTKPDTRTAALRLANTLISMVPSSVFANARAEDGDDSIIETVYENDTAEDVLEQRVKAEVAPRIVTTIFKSSEQSLKEGWSPEALVLGNSLTQYAVDKELAPLSTVDTTAWMAAVLRRLKQVRSFAVVEGLVDLVLKANRSKVFDPPVDVTADTVMSVVLDSLFRYLRADAALYHTRAVELIWDLNLLAEVHTLENVIARRMNSPTHRQEAFEAFGVLWRHSGEIFHVPMFMVLEGLKSDDPQKLRTSETWMRCNVKSYFRMLDPLIRRILNASQPIKGKFDSSQVQYYVTSLTSLFRFGGQGLSKACKTAEVSKSVNVQLVTTAEARYPNSNNYLELMVEMMTGLLKEDSRDPSRQRMQSAALELLMFLVSRGDLTSVSLDLIKTTLVSQLLLATQHRRLTLQNSMLHLLHSAITTGNEKRRGHRVTSSTFSLPEKGGAAVPVEDPQAEFDRSLVGMIETGVAAPGNRPILQHWIDFVLMVISYFDYKPLHLRTLSDAFCEQLRDTMLNLHATFTSSSIDDQAATVTEAEPIMLIGVVERLAMVLGAKAGSRKSDDREKHDREGGLLGYLPTVFSVEAPPDLPLEAARYLDNVMDALLVLWTVTQEDLEPDHLQKPYSTASQTQIMSRTRDRAQKALEKLFKGHASEVVGSSIVTWAKNSDDIADAAIFDCLDNLAPSKSALRSPANLSSNPVLPAFLEAYVSQLEGPIAVQVWNPLYAYAREVLSQSGSGASRAQLFPVLRILTVLGQIVSTTSALEDRRLRRDLQDTYVKILDAVLSGVAKGGEATTWERDGQLSADSSSIQEKQGSGTGPPVYSFVGGNVVRNLRTFLSDNDRVLSACSAISQSLVVPVFRRHKFNDDATVTLLREMAKIPPAAKAWRPPLADAFNDNRFFKITPPQSEPWKPLVCALMDSDKERFTELIGRIAAAPSANIFTNREAETVSRSLNLRRLSFVLLAAERNHYLPQLPMIQEKLVEILRNHVVSPRVHSEVYLCLRVLMCRVSPQHLTQFWPVILTELLRVFESTMDELPEDGSDDVTLVLAACKFLDLLLVIQSEDFQVHQWIFVTDTTDAAYPPDQYSPEALMDRLAEILMEHSTMSKPVENTVDIEPYDINSGHPRRPQLSGVKSLNSIYQLQPFFARASIGTFDGVYADAGVDWDAIEEGITGEIFEGKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMW8</accession>
    <name>K1VMW8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multidrug resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMW8"/>
    <dbReference type="STRING" id="1220162.K1VMW8"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="K1VMW8"/>
    <dbReference type="OMA" id="ETIATMI"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="754"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="340"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="641"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="951"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1190" mass="127365" checksum="DCD662B1B399F467" modified="2012-11-28" version="1">MARSQVRLLLRQTTVSERLLLIVGLVACMGAGAVQPLMNLPFGAVVSDVVDFATGANEAQRRTNDNVVIFCYLAVGSFVTTFAYTAIFNWAGESITNRLRGKAIRSLLSQELAYYQDGTATTRATELQKDLDTIQSGISEKLSNNIMYLSLALTGFIIALVKAWNLGLALLSMLPCLLIIGFFYGFAYIGMFMMALGPISSLTQESLAGITTIRSLGAEASLVEKVRAIQHTALRTARKKAVIWGLCMAGITFVIYAGYALCFAFGGQLLRSGDLAPGTLITVFLCIMMGSFSFGQVPPNLHAFMSALSATTKLQEIIERKPEIMSPSSAVTLSALQDGIEIRNVSFAYPARPDVSVLRDVSIKVRAGETLAIVGHSGSGKSTLVALLLSLYRVNDIFYDGVNVKDVDLHNLRGDIIASVLQEPQLFDVSIFDNVALGLPASSRALSKTEQLALVTEACRVAQAHDFITALPNGYNTMAGDGGAKLSGGQKARIAIARALVRRAPVLLLDEATANLDTVCERALHAALETTSVDRTTIVIAHRLSTVRKADHIVVMHDGVVVAEGTHQSLLENDHYRSLFHAEETRSDGSTPVNESTSSLNSPTKELEIVETASASEPTDHPKTCKSIRMMAPYGNGGLILIGVAGSIVAGALYPVFAIIYALAYSTFSTHPKDAHLQNMNALYFFICAIGGAISIFLQWFCLAYASDRLACALQGAMLRRVLRAPMAFFDEPRNSASQLADVVNNSPDRVATFCGTAMGTFIASLSTLIGGCIVGLVYSWKLGLVNMSVLPLTLGTGIVRLKVLDSREAKFKKAHEPANRVAVAAVANLETVASLAAEDIVYEDYMSKLNPKGNSILGCALFGLAQSNMYFVIALGFWYGSKLVYSGEISSRAFFATFTAIVAGSFQAVNVLTQAPELGQARGASVDIGRLLSLPEEHLGGDHPVPAGDIRLDGVSFTYPSRDDPSLRDLSLLAQHNGFTALAGPSGSGKSTVIRLLERFYEPSAGNITVGGVPLAAIDETKYRRSVALVTQEPVLFNMTIRENLLLGSTDKTEADLTRVLDVVNLSDFVGTLSDGPDTDLGAKGIALSGGQRQRLVIARALLRNPSVLLLDEATSSLDNVNQRAVQAALDAMAKDAHLTVVAVAHRLSTIRDAGTIYVLRSGRVEEQGTYDELIANRGLFASLAANVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMY8</accession>
    <name>K1VMY8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMY8"/>
    <dbReference type="FunCoup" id="K1VMY8">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMY8"/>
    <dbReference type="eggNOG" id="KOG3411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_980678_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMY8"/>
    <dbReference type="OMA" id="KDCWISA"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="267" mass="30274" checksum="1B05E1872E24CC79" modified="2012-11-28" version="1">MHELDPEPRKSDFGGRPRGDPGLWASAGQAAAAVPGVRDVSAEDFIKAYSSHLKRSGKLDIPTWVDVVKTGPQKELAPYDPDWFYVRAGEYDEKQQQEGRKSDWNGRNWDRQKMDRISIESFQQPDRLDREHDGSAQDEENERRRARELDDDGVEHGKDCWISAVARHIYLRKHVGVGALAKLHGTKHRRGVKPGHHRDSATGVERNVVQALEKIGVLEAHPDGGRKISQDGMRDLDRIATAVLEAQREEEEEESEEESEEEAEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNB6</accession>
    <name>K1VNB6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000005">
        <property type="protein sequence ID" value="EKD05685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNB6"/>
    <dbReference type="STRING" id="1220162.K1VNB6"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397504_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNB6"/>
    <dbReference type="OMA" id="WANDIEV"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="596"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="693" mass="77564" checksum="C229C6A4EFCDE26A" modified="2012-11-28" version="1">MDKADDSPNLKASRKNYRVQLGHSSPSKSPKQGQLKSQVRLSSQLSTSSRVSTSQLSLSSQVPVSEVSDTEVDEPAPATDGTSASQSSEKRGYLAFFKPLGGNEYRCRLCEKDYSGKAKMESSQLAITDMFAPIFNNDLFRSLVVLAVVHSSLQTDVWTAGSGQLSFTGGNISWIDKDWRLRTEFAFLTPLRERHTGANLAVHLYDWVKTRELGQKIVSITTDNASNNNTMLESFAGHTDISFNRSEDHIFCSCHCIGRVVFVFMKSLGCTIPSLRQPELTVPAILVNDTQPVAPHESQSSSSEQREDQETWDDFDPEQQEPDSDGEEPAIFGTSSPHGTSAAMARKFARITMRSAYHVAEFKKLSARGNALKRVAGIRWANDIEVWESMLAHEETVLKMLDRHADHYQRKHGIQLAYSDFNNLKNLIDIMSPLRKYTRQMEGDKPTGSLVICMWLRLSAHLGQMKSKYAGAEDLVSALEAAIEKVRRYQLLAVRSRPLVIATALNPLFRPHFFQQHVELGVNETIVKMALLTLCLEQREDNEEDNSVQEESRSLEEEDFAAFGSYETGREVNESRTRALLEEEISRFNNLVGVEPGSYPLRMDPLKWWQRNNTAFPNLAVIARQYLSVLGAQAVTERLFSASAAVCNPRRLGNFLPETISAQVGADQLMRGGYQAHGPWAEAQDIIDNYHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNK5</accession>
    <name>K1VNK5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNK5"/>
    <dbReference type="FunCoup" id="K1VNK5">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNK5"/>
    <dbReference type="eggNOG" id="KOG2760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015433_3_0_1"/>
    <dbReference type="InParanoid" id="K1VNK5"/>
    <dbReference type="OMA" id="RVCYVDH"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="539" mass="56854" checksum="63A4CEF9BF053374" modified="2012-11-28" version="1">MKADNSNSKVGTYQSLTFHLTTHRLLLVPSADSPNASPLQAPLSSVRQTEFYTGFMRSSPKITLYLGRGPVAKSASAIPELEPETGRESPAEVGSWTCGVCGFANPLPAGVTLGPESKCALCGVGWSVGRTLTPSGSKAGSEAASRTGTPAPSSIAPTPARAGTPASSARTGTPAAAPKEEKGKQVACPACTFLNHPSMSQCEICGTPLRKRTTSATNGAAEGGDSGEKHDVVRLSFRKGGAADAYKRLKGVLGDKAWERAPLSTVTKDGDKSGAGIDAIMRNITLSARQADGHVQSAFRDLEVMMVRAGEMVSLAQSLEAKLAAAGHGTEEEETLVRSSLVKMGLPAPALTSDMVKDERAYLDGLAKELGALLTGGGAKGKAGLMLEPGHGVLALDTVWGVWMRVRGLALLPPSTLTLLLDLLPHHTRPTIRKMQLPSGLLVLYAPNYDPEAWRRRLIHRLRQETPSSPEEIEALEEVEVIKGLSPLEICAVEGVPLGLGEELTELAARKGGIVRDDQARGGRWYADLISEWPLGQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNZ4</accession>
    <name>K1VNZ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNZ4"/>
    <dbReference type="STRING" id="1220162.K1VNZ4"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353428_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNZ4"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851995" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="5">
        <location>
            <begin position="627"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="795" mass="87097" checksum="B5BA4834EB937942" modified="2012-11-28" version="1">MTQARSWAVGRLTAGFLALRTIRWVATLPTALTVLAGPLDGGEDTGRGVDLGDGDKLVLLLLKGLLEVLGVDDATDLGLELVNVGAVSPQAVGERVSEVAVVELPPSPASTSSRRFSNQSKFSSRYSMQYSMAPFGPRPYSSMTSCRVMSSVMETAHGYGGSVTAGSRLMTHPLNRSSHQSTLWANAVAVTVDLPSAPSLLITQASSPADHGQQEWLASRYGPAADKQTPRLPLEIITKVLEDVPQETLFSTLTVNRDFSKAALPLLYRHLYFQPKRTSKRGKISPEHLRHVKMLDIFDHDLKHCEKLEFSHSPDVVRFHWNDSIEKLHKWHGDDKPCPLLSLKPKSVVFVDFDATKAPPDAKAFKNVIYPHTENRVVMWDISEELDNKGWNAAVKNVIFPPEKDDTGFESRIKAIKKGKGGEPRPDDLTRREIVVFANNTTNRHAGFGFLWWFKSFAKEHCRRKHIVVNMGAYRPRDAHYIDSLEEELWKYCANKSEESDLRPAVRRQVEGHDVIGRGGDGQGLFQFSADSSDGETLLPYLRKAFPPVLEEKLNTFRPELLQSHGMFVDSLTGSAPPSGAATPAARSMQSYSPAPPGEVREKAPAAKKSEKVTSTATIEASVDLRASADDVWSLLTDPSRIPMWSRSQAKMAPTPGADFELFGGAVSGKVKEVDPPTKLVESWNTKARTRPTLDGVPAGKEDDIERAIDQFYIQGLKSTGLVLSASSKSWLVKKAETPSGKATKAATGTRRRKRSGKQSEPTGMWGLETPQLVGIGAAATLAAVFVGLVASTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP34</accession>
    <name>K1VP34_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Flap endonuclease 1</fullName>
            <shortName evidence="10">FEN-1</shortName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_03283</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="10">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP34"/>
    <dbReference type="FunCoup" id="K1VP34">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP34"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_1_1_1"/>
    <dbReference type="InParanoid" id="K1VP34"/>
    <dbReference type="OMA" id="PTHIEEC"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 10 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="12">
        <location>
            <begin position="73"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="344" mass="38283" checksum="28AD129C46CFA29E" modified="2012-11-28" version="1">MVDNGIKPCYVFDGKPPDLKSGVLKQRFGRREEAKEAEEEARETGTAEDIDRMSRRQVRVTKEHNEECKRLLGLMGIPCVTAPGEAEAQCAELARAGKVFAAGSEDMDTLTFHTPILLRHLTFSEAKKMPISEIKLEEALKGLDMTMDQLCILLGCDYLEPVKGVGPKTALKLMREHGSLEKVVEFIKGKMAEKAAELAEQEIESEIESEEGEQFVVNSDGEEVPAPKVEKKKKPKKRAAGGMQIPEYWPWEEAKKLFITPDVVKGEDLEQPDVEGLVEFLVREKGFKEDRVRAGAAKLSKMLAAKQQGRLDGFFTVKPKTDAPKRKAEDDKKGKGGKAAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP96</accession>
    <name>K1VP96_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP96"/>
    <dbReference type="STRING" id="1220162.K1VP96"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_829457_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP96"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="37705" checksum="3FD9EDF4BA397C5E" modified="2012-11-28" version="1">MTVRVNSKTLSEHKGKTVRLTAKVVQIVGDTATVEASDGGQDMHIEDKFVEIIGSVRDDLTVRALTSINLGPTLDMKAVNAVPAATPKAVPGKSPTPPARESEPRRAQTWGRKRIDCLDVHCSEAWWRVFAAFDPVARYPFSEYGVFNILLHVNRSTLNDVGYERKGTHTQRTRGADGQTALALTRVWHHASAEDRILGTLASRIAWVLMGKHKPTYDPAGKWRRFRHYADDSVDAGDYVVVSDALKVRLTGNKAQEKIYRHHSGFIGGLKEVPITRMRERRPEEILRRAVSGMLPKNTFRDRRLERLKIFPGPAPAHYEQNVLKTWRDKASESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQC6</accession>
    <name>K1VQC6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VQC6">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQC6"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQC6"/>
    <dbReference type="OMA" id="NSEEWRE"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="3208"/>
            <end position="3543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="929"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1716"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2015"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2340"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2407"/>
            <end position="2491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2852"/>
            <end position="2914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="936"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1304"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1364"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1716"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1733"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2015"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2029"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2069"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2407"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2471"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2854"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2870"/>
            <end position="2900"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="3511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="3543" mass="389279" checksum="A0FFA5216C101CC9" modified="2012-11-28" version="1">MRPRKSTRRVVPPPPDVDALIKRLTDASEPDVVAVLKQLQIWRYPRADMNSFLPVTKKFGQILANVREKYGFGAAATGDCKLQIESFSAEDRTLVLEILRFFRLLMENSTNRKQFDGYEVSSTVAKAALFVLQRSLQQYGTQLPVTPELAQSIRARLLALSKGWDRFSLADLDLEKLASETGKLEIPDDVAQLKLQFYPPAGVAGAVASPAKATTGLASTAQDTPTRPSNRPPPSMAVTPHLNAAAKNATTPDNGMVTVDLGNILTTMSPDTYLQQVAKLPTDYKMDVNEQLNALNKIRVILFSGDRDSRRKLLSSRLLALACYNVVQSTIWLFEPELVNHMAELLVPGRDVGESVVASAVLALEAAAHHRTEVLTSINAHVSHGVLMGVLRSISQKLTTDAEISYDVVDAVLAFLSFINSQPQYGNLLVGAGLLPILLQMLDTKGPRRNQIIPRTAGLIDSAVFSHQQALQALTSADGVNVIVGRIKAEVQNVLEHPAGQGTQMFSRDSEIAWDTNPLKALLRSIYRLLQSTGGSEGFRNVVDTDLPKSLKLIFTNADKFGMRNFSLAINIMSTIVHNEPTSLAILQEMQLPQTLFDVLEKQMPDTFEVVYTLPNAIGAICLNASGLQSTLDHFSVVSNMIKVAIGWTVDSDAGERDQVASIGASLDELVRHHPGLRPKVLETVVSVFKDAIADAEQFKPPLAEVNEYTAEPAPASEETAMEVESPKSEKADKTEASKDKVISNPPLSKLTNILKLLTGLLRNAAMCRAFVNEENGLDMILNLASLPCIPVRFSLTEAAVAIPGVLRVIGDHNPVKLTERMTNAVKDELEALPQLWKDSDAHSNWAALTKEDGTPEDHLLLRRAAGLAMRLSFLSEYLSMNFGSKREATDLIKLLGVTSGSPLMNNLGQLHRIAFQEHVILKDVVAAQNPPSEPTTPATTDAPAQGAESSAAAAPGEGETTTAGETTVTTTGDRSESQVIEIGRDASDLSNKPPTRAQTVKTIATRMHAILTKFFKASIRLIFNKRIPDASHKPEADALGECIASIIIGHLQSSAQVPSKAFAIDTVALGLAAILLFDERGVEGSMQTTLFIPFEKQGGVNVILDTVGRILYHLDKITIIPQADRTKEQAEEWKTNVAGARIATSILEALSSYRALVNAAQTTVIQEREAVLPPEKRFQPHATHLRIECAVLPTAFKLWNSNWLPHMDQDIISVANCMVVGMMNNRIEKPPDLMEPALSSSDDEEPPVPQPLRPQVTADPARVTQLTEMGFGRGAAQRALVRTRNNVGAAADLLLSMPHLFPNDDPGTDDTPAPAENAQATPAATEGAATEGGATADGAQSTTAEASTSTATETPAEAGPSSEEQKPEDKKDNKNSKDDKKDDKEESMEVDKPDLPSPETVFEQAREQLFELREKYKPGMPERAIEIIDQTQSAIPDLLGAFDFTPEGAEYILKRIQEAATQQPIDDKFLSARLRLLAVFIDSQTTASGGTQIELTEEQAKSAMQILTSIPIDMEKRPTWLSEYLLAVEAVFQMGWTITPTSIGDDAVSNVVTEVDFGDAYQKLQKLSLDMLKAEDISRPDMMSAMRMLVILTRRTPSICTPDVMKTILGAFKTSTSHAVGSFALLAIVARHSFEKDALKETIDREVGSFWIAPFGPGNQRNGTELDFMIRQLRQVAYRDPTLFVDAVQEQFNLVNTKPHRRGLDINSKVSFRIMRKEKPADEKKDEKESAEQNQGQTQAQGQNDPFTKTNFDSFENQPIMDMLVSELGTTLRSIQQEEANKRNGTDYTPACAELYSYALLLMSVMTELVGSYISAKKAFMAAVRKHMLYGVGKGKSGLGAILTDVVSCVSLSDVHNKAAGAANPASQRRLTMSSWAISLIVALCSNLSITPDIKEIPEDLVTVRKAVLDGISKALKDCASPSLDLGSRYGRLWALGELIYRLLTARPTIVPKMGQPADDSGLHLAKTMLEKNFVSTMTSAVSEVDLNYPDVRNVLLSLLKALEYLTKISNKWGKSDNNKGGESEHPEESEEDSESTSDDSEMDMSDEDEGTPDLYRNSALGIIGGDIDVDDEDDDMDGTDDEDEDDLAFDEMEHDMDDDEGTEPSDDSEDDMEEDEDMEGEWDEEDGEEDQGIEVGAELDDMVETEIPWEEDDMGEEEDVEEYDSEDEDQFDENDIGMEFDMDEEDEELAGFDEDGYDALDAMDGIGPSHMDLGEPSGAWGWQDPAARPGARRGLMDMDRAPTSLFGFSRREPVNVNRHPLLYTNSSRTMGDPVRSNANPFGALSSLSDLISSIEGLGGPQAVQFLESVVHQSRHSGADTIRVDLAHRSDGGFGLSIGGRSISVAPPSRTLPSTPEEVQREYRPAPTLPRWMDELGVFPHDTPELQERIFTHIVNRLMPAALRAAAEEEERKEKAEQEAEEAAAKKREEEAAHAAAIALPESRPESRPETALSDAAAEEDVDMMSHDDESGDEEEDEDEDIEDDGRERVTINIHGEEVDITDTGIDLEFLEALPEDMRADVVEQHLREQNRLMRPPASDVPAGSSQINPEFLNALPPEIRAEVVMQEAMEQERARRTTQPEPEPAAPAIEPPLQRGEAALRELLAGTTDALFFGPDGVPRNRELGGPPGLKIFPLKMGHEPKPKRDAIQLLDKAGIASLVRLLFVPEAIRKGYLIKTLVHLCENSKTRTDLLNVLLSIVQDGTGDLPAVDKSFQQMSLKGLATPQNKATPKGKVLETPASQITSGLFAHFQSDHIPTFIAQRCFEALSYIVNANQQAVMYFLTEHEQPVGLKKPASKKGKGKEKYLPQTKFPIVILIGLLDRPNLLKAPGMMDSLTSLLAAVTKPLAQLPQQEKEAQEAAKEGEKKNAAPTAGAITAPPAAQPVAGAGAGAATTSGTAVEKAGESSKPAPSTKQILKAPVIPAPVLRLVVNCLTIGDCSSKTFRETLSALQNLSYIPDAKPVLVQELCARSQQLGGVIQGELKELATMLADKDHEVSSDMLTTFSPAGSSQAQLLRLLKTIDYLHSHPHGRKPETEKEQTEDEKAARDIYNSFDFTQMWKQLSDCLTLAEERESTDQIAAVLLPLVEALMVVCKYTRTPQTDAVASPTSPKSPSSDITQSTDLFISFTTTHRKVLNAIVRHNPALMSGSFSLLIANPKVLEFDNKRNWFFQKLRRKREALNYGTLHLNVRRQYVFQDSYSALLHRSGDEVKYGKINIKFINEDGIDAGGVTREWFHVLATQIFDPNFALFEPCAADKQTYQPNKHSSVVDDHLSFFKFVGRVIGKAIYDGRLLDAYFSRAFYKQILGRDVDMRDLESIDPEYHKSLQWILDNDITDVIDQEFTIEDDSFGETKIVELKEGGAKIPVTEENKAEYVRLVCAYRLENSIRDQMKAFLTGFYDIIPQSLIQIFEPDQLELLISGMTTIDVDELKNSTQMAGWKGSDPEISWFWRALRSFSQEERSRFLMFVTSSSRVPLGGFSQLQGASGTQPFQIQKLYGKEGILPQASTCFNLLLLPKYASYEQLRERLLFAITETSGFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQK2</accession>
    <name>K1VQK2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04028</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQK2"/>
    <dbReference type="FunCoup" id="K1VQK2">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQK2"/>
    <dbReference type="eggNOG" id="KOG1709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033831_1_0_1"/>
    <dbReference type="InParanoid" id="K1VQK2"/>
    <dbReference type="OMA" id="YWVVDNY"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RMT2" evidence="11">
        <location>
            <begin position="164"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="398" mass="44076" checksum="FB264B6D9095BC30" modified="2012-11-28" version="1">MAELAAAGVPVQVQLPDEALQLAHALLAASQQGTISDVAGLLERDAPAWYQDDSLGWSCLHYAAERREPALLRKLLSGGAVWNAVDKWGRTAGEICLSLGDKTGWEIIRNEGVRAEMLHHALREANKLKAAEKEEMTVEPGEEGKEGAEVTQTGDGITLRNHDESSAGDNLAFLASKLTWETGEDGRERVLDADGNGVMMGWEEPLMREHVRLMAPREDLSILNVGFGLGIVDRLFQETKPRSHVIIEAHPQVLQHMRETGVYDWPNVTVLEGRWQDFASGEGLEKLLEAAQGGFDAVFVDTFAEGYEDLKAFFEILPDILDPEGIFSFWNGLGATNPTIYAVSSSLAELHLDDVGLEVEWHTVPIAQSLAEEVWKGVRRRYWELPGYQLPIAKMRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQL2</accession>
    <name>K1VQL2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bsp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQL2"/>
    <dbReference type="eggNOG" id="ENOG502QWKJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235411_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQL2"/>
    <dbReference type="OMA" id="CLVRVRW"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="234"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="1797"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1712"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="860"/>
        </location>
    </feature>
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        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
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        <location>
            <begin position="880"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1113"/>
        </location>
    </feature>
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        <location>
            <begin position="1114"/>
            <end position="1172"/>
        </location>
    </feature>
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            <end position="1186"/>
        </location>
    </feature>
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        <location>
            <begin position="1211"/>
            <end position="1230"/>
        </location>
    </feature>
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        <location>
            <begin position="1244"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1561"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1600"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1661"/>
            <end position="1679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1919" mass="202249" checksum="95CB894AA2C80CED" modified="2012-11-28" version="1">MNGIWNIDSALALNQFPSVEDRVALSTNQWADDLRGIYNNARDRFSDVAWETDTGERIFAHKAVVYVRAPKAFKDRYFLFLQNNQNRAGRSQTSLAIARSPSPSPFSTTPPFANGTSVRNTPSPSYLAAARSSSLSVDTIESDGTLRAPTLNTGGDGILKLGQDDPPEMFRAQLEWLYTGEGFGDVVEWISGDGAAGPGNGNLRDSLGRRGNLAERRDKLGNDLTYMWTSKLYCDVRIHLEAPESDGYGSDTSGDSDDSLAETVIFTAHRFMLVSRSPYFASVLLNPSSFRPATADVHLPTPPFTPAALHFCLGWIYAGHLDFSNRSFDLSTALQIHRAAAYLQLDSLVSEVESRLVYDFCDNMDWDRCHCRRCLSRVPRVWRFTCSPDVGAIDLHKRARRFMIAGWMEAWGREVGSADKKDRDDLVKDLTKTLTPGSVITVFRGVARLRRRMSQAIRTKGPDATGWTDAVEEMVEQIEKRARDLIATHFVAVCESKELWDALTGVGMNEDALDAVLAEMVEIAGRPTTSVEAPRMYQTIVSSLLLKVNPETLQPMLRTGSQARHKVEQTKEGVLSHIRRRWMGIKDAAGFVGLEPWSLKEISDELDLPMDDLLGVAFPRSSAGFPRTASTAAGLAESNSSTGGSRAASRADRQSRSSVDQASEISSGSQTSQGPGHANRASVSTLRGVETPEPSERNGLRRLRLSSSASSASVTSSRAASRAAAASQSSRQTPTSSGPTPRSPTAASKTLVVSVGSRNRVSPSLGSPNSPTPTVMSGPPRPLLTGKRPVSKLKSDNEKTGDSPSPRAGPSTLRHQSSMSSVRSTPSAKTPTAARTPTTRAAVSSRTATSSNASAKSTARPTPANKSPTKAVSKSPTKAASSSRPSLSSTRPSARLRTVSTPNAAAAGAKTATPNTRPISHSRTSSVASASTASSAARAAATVPASHSRTSSVSSSTAVRPMTAARPSRASSTASVSARPAPGRATTGSSSSSATHSRNASVTSAASSARTPLTGGPPARLTRDSAHSRNGSLASLRSFKSAKSTESATATPKPAPRSGMTKSASMMSVRSTRSTTKPAETPKPATSRASTGSTAPSSELKTFRTRSVSMANLKTTTPTPRSSLPPSTTSKTPAATPKPGTSTLRPRPSTASSTRVRTNSTASSTATGTGTRVRPRTSSLASTRSHATIAEDPDQPPLPGDAKDNVRATRTRTMSMASAASRASTSTAASGVEETTPATKTVRPRASLTAATPTPAARGKAAQPSTTLAPLTPTDAGSGKMARDQATPKAAAKPSAPSKAGTLRPSTSSRNISRSVSESTLKPSNSARSLSSKTSRDSGAVTPKASNAKASLEPATPTAPKQRSVSAKVATPNASGTPRRSTSGLSPATAGTPRQRAVSAGASLWKRATPVPPKVAGVVGQDNTSPRTSMSPRASNSPSASTVSGLKSASRGRLRSSSGSTEGPSEAITPRMSASVEPIIAQEQEDAACAPPLQNEPSPDSKSERPPSVLLHRPESLVVPEEPQEEEEREDKPEERNEVTTPETEPPSGVTVTLNDEPDELDPRVTPRATRAERARATSESTTPTSAQYPPAVFGVPHRSASSPVSAISDQPIRPIIPPRTASITVSVTDDESDTRSRSGSGSAPLPIPGASMLSDEPVPTNLPPPSAYTTPKVPPTPPIASFSLPNTPPVRPTSLAASPMSAASLHSVLSTAHGSPAGSVRSHTSPYRPHPAHAFDPPPRERPAPVPVAVTPPKIEVTDENVPFSGRGVSLHVGIPCIVALTSRRARFRANAKYLGTLQDTKGQWVGIEVEDLDRFGIETLPTGARNGVRYFHFTVPSTPAPGPEARQAREMRLRRIGSIADSLPRRRLGALGLSNPSTRSASPFGGSSYAAEWVAPEKPRALFVRPEEVLFVMGADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRX7</accession>
    <name>K1VRX7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRX7"/>
    <dbReference type="HOGENOM" id="CLU_2265588_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRX7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="103" mass="10734" checksum="80485EB6A89715C9" modified="2012-11-28" version="1">MDPLDSTSAWGGSSAVPSPLPSATESTSGPWGGSSAASTSSSTVPDLREPRVYGDPVPALPAPNEQQAKQIQAPFLRVRIAGVDRNRKDLLVRFDSSVSTPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRZ1</accession>
    <name>K1VRZ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRZ1"/>
    <dbReference type="STRING" id="1220162.K1VRZ1"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_2_0_1"/>
    <dbReference type="InParanoid" id="K1VRZ1"/>
    <dbReference type="OMA" id="RYIMADY"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="435" mass="47511" checksum="B5AB982CA67CD8A1" modified="2012-11-28" version="1">MSSLMSATSSTVVNKAQWKNILVVGGSVAGHSFVNAIAPNLPPNYRLIIIERNEFVQHSSFVVRALVAPGWENGDFTAPMNQHTVFPINSRHRVVCPNRVVKLRRNTVWLEHDFEGSDEIEFEKCVIATGAQSPVPIRPAPGSTLEQWKDELRAKQAEMKDAKSILIVGGGSVGIEVAGEIYDLYGRTKKITIVHWDVGLLHPSDSGANTKHTYVPPRTSMKLVSALQRQLTARGVEFVLCDRVDFSAAEAEEWGGKSGALGEMKRVPLVSGRYIMADYVFDSTGNKPNSQLVSSVDPGAVTTNGYVSIDSMFRIRGSHPQSIFKGQYYALGDVANAPSWKTGVAAMSEGEALAKIMTAEIKGWPAKPYSPSSKLKESTVLLGSRGGAAIINLPIIGNIRAPDFVVDRKSRDFLADKIFFSRFRQLGYTDSTVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS03</accession>
    <name>K1VS03_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS03"/>
    <dbReference type="STRING" id="1220162.K1VS03"/>
    <dbReference type="HOGENOM" id="CLU_158158_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS03"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="125" mass="14043" checksum="C4A53379F74F0785" modified="2012-11-28" version="1">MDDKSQPPQYGQPAYGQPGYGQPPQQYGQPGYGQPPQQYGQPAYGQPGYGQPQQPYQYNPQQPYQAAPVQQYPPQPSYGQPPQQQYQQPRSSSTSSSRPSCPTPRRRSTARTTRRAARSRRSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSB7</accession>
    <name>K1VSB7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSB7"/>
    <dbReference type="HOGENOM" id="CLU_071129_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSB7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="37818" checksum="49AA6ACC912533F4" modified="2012-11-28" version="1">MSITPPPATWTTHRPGAHGWRPGHDYNPTARTFKKVIILMENTPTYLVGELDNYHPNEHGTQFWAVRMMFPVAPEQFNLTVRLQDNQVWAVPTSIWNEAYEAQTRIFNVGMITMMGHLEQRFHSISAEIGVSFGPTFELRALALQLGISAGHCQVAAHYQLLSIPPTIFHFGPYTIEHFERECRSEARMVAREQARQSVILQAAGGPSSSWPGVMHPYAYIAPTHSFPSTLSMTTGQLSHEGAMSSAYTTASSSRRTTARESWISTRIHSVQLPSQQSGTYPRLPVDRSVTDTTITEEEVSYFSEHSGASEEGHTDATQEESRGRWWGSLRGWRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSH1</accession>
    <name>K1VSH1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSH1"/>
    <dbReference type="HOGENOM" id="CLU_1563988_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSH1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="171" mass="19275" checksum="65FEEB6AF47E35D7" modified="2012-11-28" version="1">MQRYALMPRLLTSERERRGHWDLYLAQNLTPDPGDTSHRLVRGDHLPPASPLPSLLFPSCVTRGHGGRYLDPTPYRVIHTCASLHSYDLLMTNQRSAQLALRRVLPEDRKGRSSGMAELELTDSSQMLAEAWDHESRSEDNLNPGVALAVRAPRHPTRALFAHDLHVTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSR4</accession>
    <name>K1VSR4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative polysaccharide deacetylase from carbohydrate esterase family CE4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSR4"/>
    <dbReference type="STRING" id="1220162.K1VSR4"/>
    <dbReference type="eggNOG" id="ENOG502QU9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="InParanoid" id="K1VSR4"/>
    <dbReference type="OMA" id="HMFIKSS"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="304" mass="34748" checksum="A1975BF62CB7DEA4" modified="2012-11-28" version="1">MPGRIMCSFGVDVDAVAGWLGSYGGEDSASDVSRGLFAGEVGVPRLLKLFKKLNMKTTWYIPGHSLDTFPDQMAQVRDAGHEIGLHGYSHENPTSLSVQQQKDILDKTFKQMTDFLGHPPKGSVAPWWEVSVEGAELLLEKGIEYDHSFMHHDSQPYYLRTGDTWVKIDYNKPASHWMEPVKRGETTGMVEIPVNWELDDLPPMMFMKTANNSHGFVDVRTIEQKWKDHFTYLYENERDTGFIMPITVHPDVSGRPHVTLMLERFIKWINTHDGVEWVTMQEIADDFRKRVPPPKGARMPKGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTK3</accession>
    <name>K1VTK3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5 14">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_02861</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="5 14"/>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTK3"/>
    <dbReference type="FunCoup" id="K1VTK3">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTK3"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_3_1_1"/>
    <dbReference type="InParanoid" id="K1VTK3"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="673"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="709"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD02917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="777" mass="85533" checksum="69BB01D48CD633DA" modified="2012-11-28" version="1">MFRGGTIARRAFMGAAAASAVVGAYALSEVRPTTLLESNRAAANKKRPGPLWAPMTRAEMLAHLHTSGVFIKRTSEGGPEPGPVDPNYVPKDGDDVFDLLIVGGGATGSGTAVDAASRGLKVALVERDDFSSGTSSKSTKLVHGGVRYLQKAVMELDYEQYKLVKEALHERKIFLETAPYLSKPLPILLPIYTWWQLPYYYAGCKMYDMLAGGENMEGAYWMGKNRALEAFPMLNPQNLVGGVVYYDGQHNDSRMNISLISTAVQQGAIVANQTDVIELHKKPDPKHNGEPRIYAATVRDRMTGEEYMIRCRGVINATGPFSDGLRKLDEPTTQEIVAPSSGVHITLPNYYGPNSMGLLDPATSDGRVIFFLPWQGNVIAGTTDSPSSISQNPIPSEHEIQWILDEVRRYLSPDIKVRRGDVLSAWSGIRPLVRDPDAKNTESLVRNHMINISPGGLLTIAGGKWTTYRAMAEETVDAAIKEFDLHPNGPCQTEHLKLVGSHAWSPTMYIKLIQQFGLETAVAKHLAESYGDRAWTVASMAEPTGLSWPIHGVRLAPLYPYIDAEARYAVRNEFALKATDFIGRRTRLSFLNVQATLEALPAIIDIMGEELNWSQQRKNQEFDEALQYLKSMGLPENTQLKLSDLKRRGNVPVFGLTNSTEAALYARSAFSPKELARLKEQFAHLDFDNDNRITKADLVFAMKQMGYDASDATAARILSEVDFGRKGSLDFQDFLDIAAGLKELQIESAFTHLAKLDEKVDPDAVPAIPVERSGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVS9</accession>
    <name>K1VVS9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVS9"/>
    <dbReference type="eggNOG" id="ENOG502SWEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1548706_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVS9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852498" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="173" mass="19108" checksum="FF19D9CC00BB628F" modified="2012-11-28" version="1">MLCFTLALLFVAGAAALPLSSLPEKTVQVETRGPPVFVVAGLAVTVAQAVTVWEGDDKESRNQFTASVIDRVHESYPDCNAFIYHIGEDTFTYEVPADAAKEEVSIDHGGFLGWFGVREHYEIVVFDGPGKLERRNSDGGYLNWAFVGWYEVDDDKRVVTFSAPPDDGEDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVU3</accession>
    <name>K1VVU3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LIM-homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVU3"/>
    <dbReference type="STRING" id="1220162.K1VVU3"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370948_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVU3"/>
    <dbReference type="OMA" id="MVTHVAN"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="625"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="750" mass="81352" checksum="6A42C75BC5F513D4" modified="2012-11-28" version="1">MQQVGFTPDGRQQVAYATMGQPGIPPQQPPQQPPQMQMPMQVNGYGGEPTMRESVEGIPQVHFQQQPAMPMAAQMPQSFMPAAQYTVPAQAYPTYYPAMGPQPGFPQMVTHVANYRFGAPMGGEWEEDFDETGGAVLYGNLEVKHRRRTTPEQLRVLEHWFNINPRPDNQVREWLAGQLGITKRNVQVWFQNRRAKIKNQEKAREAAEKEAAAKAEAATTASTDTGKSEDEDKATSESKPPTPPVPQANEPTERPSQVQQPHPSQPPQQQQQQQQQQQQQQQQQQMPPPPQPQVQQQPQPPPQQPQPSPLQQPQPPPTLLPSPDKLNMGRRVSLAGGESANAVALQAKRFSATSPHSPGGHNSPLGMAAAARRNSQPYPTQIITQHEEGLGAARPLASPKVSPNNNRMPPALLFTAMRNNILRRASMPGGAQLMSTTVFAPPRVGNVNFSETNTSPSTASTLTPIKDQESQDVPVTFVTPPTDSFLHVPNDSYLNPGMPFAPNSPLPNPSFSFGTTPSSDSVPTSASSTPVGDDPQSIFMALQRGRLGSIASVNSVTSVASTVTEGTTEGGSDLEPWQYTPDGFDPDIRRASAPADLLKNIGMLGISHPSGVSSASHLTRPSPLAAAQYQPGGLDSVNYELPPQHQQQPNGNMGGGPFIPAPDSSYSSAASNDTDSPSRMMPPPSQIPNHHFPFPNHDHPNLPEPLPEHNPQQQQQYTQTAGDCSEFFDDQAYANFINGTGDYEPNKNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWC5</accession>
    <name>K1VWC5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWC5"/>
    <dbReference type="STRING" id="1220162.K1VWC5"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877217_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWC5"/>
    <dbReference type="OMA" id="CEIHTIG"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="332" mass="35561" checksum="7F16233E5B6CB2AB" modified="2012-11-28" version="1">MTKQVQDVPIFEAERVLECGNTLGEGITWANGQIVWVDIEKASVHTLTGDKHETRTFPETRYVPAVAGVAGAEDGLVAAFHDRLVHLPSPSSSPEDIALLIPEEEKSAVRLNDGACDPAGRFLVGSMNLDGLGISPPLGKLYSVSPSSSGGYQVKTLLEDVGCSNGIDWTPDGRTMYYIDSAHPRIDVFDYDVSSGSNCNRRVFVTEADLPPLPPASHVPAPMVAFDGLTVDGAGNVWVARWGESRVVCYRPSGEAILQVVTPEARTPTIPAFGGEGLDELWLATASAELAGQKAQDWPRSGDVFKLKIGQEIKALLGGGWKGRARHGFRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWD8</accession>
    <name>K1VWD8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWD8"/>
    <dbReference type="FunCoup" id="K1VWD8">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWD8"/>
    <dbReference type="eggNOG" id="ENOG502QV7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009212_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWD8"/>
    <dbReference type="OMA" id="VTMCIDA"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1080" mass="115302" checksum="1257F55B6BAFE9F1" modified="2012-11-28" version="1">MDPALLQPSLHQAKAEDVKPAATTAGTTPQTTKPPVTNGSSATEGRTAADSSAPTAQEDDADASDTGGDGVKRPRLRLAHACDRCRKRKIRCDTQQPCGPCSATKNECTFNTPSRRVAKPKGEARSSSTSGVKRPHSPTRSGGNSQYQASLEARLATLEALLRDVPPNVHNAYLSTLDARLGAGQGVGMAQGKGDGVGLSAEALAASGPMLGGSAFSSAFAGLKGDTTLAPAWSAPTSLTGAWAGGRSLRRREGNIEDVTRRMETLSFFYEDEIGQAKWQGATSGFPLLEILTAAKTQSEEEMSPDTSSPSSTEAAGNQPAAAPSPQDRVGRRGTPHSVAGGGGRSASVGASKRSSSTPPMKDRFFPDRTPRPHQTLNPEASWKVITGVIPPDLMDTLVRCYLSTSHLLWPFLHVPSFLADYANPQQWGEPGFACFIVAVCTLSSRHVDDPRVRANPSDPSTAGKQYFELFKRLRDLPSADRPTLYSIQAAFLAAIYAFGLGNLSKAFALQAESVTLCLDGGLHRSVDSYDHFNPIECETRKRTFWSIYSWDKQSAALFGRPPIIHLRDCDVTEPMIIDDENLSADGAKEQKNPEQSRMCAFVAAIRLHVVLEGVIDSCVHPSSFPSSPFLAQASATICRRTPQNESLGDEEKLLEEWSRILPKYWAYDAETAASRDPIRITQAERLHCLEHLVKMIIYRHRFSGFVTQPASTVEEIARHVECCRRAMQCALTIIADHVHISQRGMMTYYGVHVIHQLAQAGRTLVAVILNCKNPEFKALIAPSVEGLRSCVGLLRRFSGRYLCGLRSADIIDEFCRVCNIPVDSPRVPDSAGRPSPAWLRPVRRRASVSPAPSGLRNRLPSDFGQDIMSAQPDLTAAQMPGDLESVFNTSEYFDSGPMDISTSPVKNGTALPSTNGNNNASTTTANATSNLNGINGSNGVNGVNGSTGNTSGFGAGPTLGEPTAAFDRLETLSPNENLGSLGNATLQQYINSHANSNGSTAMEGVQFTNGDGTDGAPSTAMDSVGDGLQGAASGGLSAATILSLLEEGTFDYGSIFTDQAPLPDFDFTTGMISENGTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWV3</accession>
    <name>K1VWV3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD05001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWV3"/>
    <dbReference type="STRING" id="1220162.K1VWV3"/>
    <dbReference type="eggNOG" id="ENOG502S879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_2_1"/>
    <dbReference type="InParanoid" id="K1VWV3"/>
    <dbReference type="OMA" id="RRIDWEN"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="142" mass="15643" checksum="EAEB688B846DBF4D" modified="2012-11-28" version="1">MSEAKKTWFSDLPAPTSIPTDISVSELGTLMDDPGLTAGKDYIIIDVRRTDLDDAPGNSVHPAAVNLPAQSFYHTLPMIFALLHSVPKVVFHCSSSKGRGPRCAGWYQDYLNEQSFKTSAAYVLIGGIKAWSEAYPDRIRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWY6</accession>
    <name>K1VWY6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWY6"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_6_0_1"/>
    <dbReference type="InParanoid" id="K1VWY6"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="528" mass="57838" checksum="A89044C9CBB2BE54" modified="2012-11-28" version="1">MIDRATLASLFGYASIACWLLAQFPQVVKNWQLQSCDGLSLPFLINWLVGDVTNLIGCVLTDQLPFQTYLATYFVFVDVTLVGQYFYYAPRTKPPPQPESMTASPRTSLILPRRTSSYSEHHSPILPRRGGSGKGHARTAPCAPPVDSAEAMYAAALDVARAAERISRRGGSGRGRPRHHHTLPPDASSSTEHIRGSVSSSQYSEDEDDETRTHHHRMTQSLVLPPRPPRSSSWLSNDDRGRSLTRISDIASGSQTPDTLESQLPELRRPKRHHSRSQSVRAHGTGRRAAGVAFMGLGFIFMRATSTGGEAGSTAGGHVVPIASEAEMTSHPWWQPKYPAPLPSLYDAPTTVVTFANSSHPGGGHDDDDDDDKPGGPHKPEPINIRELIGRFQRRSVEGLSMLLFLMAFCGNVFYVLSILVAPVKPDEQIHYLFLAHLWQEQAEGAACPAAAPLKNVRELRPFALPTPRGRRAPPAPRKPPQEESYGPPLPQPGVPKCADAQRDGQQCCLAHQQPAEANVRVRDDAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXN0</accession>
    <name>K1VXN0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXN0"/>
    <dbReference type="HOGENOM" id="CLU_448481_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXN0"/>
    <dbReference type="OrthoDB" id="2594563at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="68338" checksum="14B152639AD64DD7" modified="2012-11-28" version="1">MATATAHPISPNSLSPTLSINGCSEPPRKRKRHTRTTTGCKQCRVQRVKCPEGPISSTTGRKIICRRCWETDQPCFYPIKGMIKRGKSKDRDDAWERAEDVEEWCPVSGGSDSAHDSQDYQHQFEDRDDMTIIDWTALPAAHVNGTHTAAFITSVDTKPMLHTQHAHIAPISAGSIPADATIQPLSMNPPHANGVSVHPYPPAYGYTNVDKTLTVDMINYLLNPAPMNNIDPISLAAMSHSTGDRAVVSYLESRGCNEIQSATQVKHNWIFQQLFPRLLTVLSAPVNADEAGASVRDWLHHSLIQLAYVHRGNIDADTTKAWHWRAAAARHRQKAGCAILRAKVRYPEREWQTEEYFTAFELPLDQSSSFYPSLRDMISLYATIQFSCTPLDVCSNMQPIFEMSPVGPEWVERFVGFSRRIVILLGRVHSLVVQRSNMLRSGGKDGSRASQIEAQAQELLVQLNEGWDWEEGNLDVGRSDRIQRGNEVMRSALRVMLLCEVLNVDLSDARLERERQRAAELVADAEPVGMGGFQWALTIIGMYTRDPDMRSRIQHLLKFVLSLSFGSNYRGTDEILDICWDALDRNGQYENGIAPWRDAMGALGRNLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXT7</accession>
    <name>K1VXT7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXT7"/>
    <dbReference type="HOGENOM" id="CLU_508239_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXT7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="536" mass="58003" checksum="857826856954E176" modified="2012-11-28" version="1">MATTRTERLLCSECPKTLKSTTTLRTHMIKQHGWIPTRKRGRPPRPSAVKASTAPAPRPQQRKQATEAGRGQATKSSRRRSFAGEVVDLRTPSPRLNTSTAHALPTPPSSAGKGVITAPTWSTANAEPESGANLQLPQYSPFDSKTDEVDEIISVRSNDDAVKLEKGKEREKPRKRKRSTRERTRPPQKRLAILSESPPDEEALATPPPTPPTTKPAHTGKDKGKGAMRPSPRPSETGSEYEMIQPPSGFDRFLDHGLGPEEPREEDGFQPMRRRSSKAGASLEQLFPNRVPLKREKTPVAPDPSNSRYAIRVEDAGSEDEKSRHDGLKSDSGPILKTRTPTPSQEARAPGSASATVGTEADLSLQKEEPTKDSPRTEPLAQLPEQPEQPPKEMELEQKSDAVGNITTAIQAATLKQTEEEQTTGRGTMTELVATREAAAQTEAIEPHAHDKSSDEPAELKPVGVSPTLAALAGGGLASLLPALMALQQGQQGGMKPEYHAEHDCALECEVCRVLATVLHGLHRGGMLGSCCGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXX1</accession>
    <name>K1VXX1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01398</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VXX1">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXX1"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="InParanoid" id="K1VXX1"/>
    <dbReference type="OMA" id="RITGHEY"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854103" evidence="10">
        <location>
            <begin position="17"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="34"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="249"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="365"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="643"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1089"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1379"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1393"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1416"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1455"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1510"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD04367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1529" mass="168414" checksum="33C2A43F359169B3" modified="2012-11-28" version="1">MKWLAGAAAFAAVAAAAPQSSVPFSVGVETAWSAPPLLLEILETAYDESASSYFPLLRLITSHIVGLRKTPESQYEHALQLMGSHHICSGDESTFNLALSLHTTAPRIEAAFAQYAKLDEAALGVTDCAAWVEFQGKAYCDAEKLRAAVERGIDGNSTEVPIRTLPFDHVSGAEPKAVFYYSPSPDALPLLNYLDKHTKSVPEFAYVVRYRPTGERTRKTPLSGYGVEMALKKTDYLVVDDRARAKGGVGVNAITVIKNAKNPLKAFTDLSQNLPKYTAALARKVSAPDSIKKRARITGHEYPVSPLFLLNGKLTGRLLNAIRSERPYINTLLDIGFTPKEAVELMSDEVIGTAQASTSPSEGLVDASDREEGGNVIGWMNDIENDAHSVTNSQYMRPVYPGQLHLVRRNALNAILAVDLSKKIGLGTVANEALGFVRRGVPVRFGVVPVGDNTAGKIFFYINEKLGREAANDYIKTLDTITEGGKVTDVAVETAYESITESAVGEWPPFDAVLKSKLVTKRSQRAQDWLERVGITPSEATGGTLMVNGKPIAIGVGWTRALQNELISMTQMLQQLIVGGAVGEDSDLSTVFYDLPSTLKRKAKYIVPKQGEKLVVYNLADVFNGTADVLAENFVYPAEGCRSRLGFVNVQPPGGSGLFSSLLYELISTGQLNTIKPSQLIEFIDELNSRETNIDQLTLDEIQAGQAPQELDTEGKDEPLNAFTGAGWTVGVTAEAGKFWSVGNTVAHRLGVNGTQPYVLVNGRLIGPIDEPDVLRPKAFGLLEDFEGKKRVDPVAQLVASMSIGDGKDIPRSIQIGDFENALYHFGVIVDPISETAQRWSGLLELLSSLDRVAISVHFDVDPRPKEIKVKRFYRESLRAQLSFDVDGNEVSPDVRFVDLPSSPIYTLGMSVPQAWIISPTDSPLDLDNLMLGQLGEPTHVLFDLKQLVMDGHAREGVSTPPTGLQLQLRAQGEDEVVSDTQVMTNLGYLQFKAPPGVYDLAIRPGRGEEVYELQSAGNEGWESPSVQDAGNIVTLTSLEGNTIYPRFTRKEGMETADVLEVDEPAGWLSKIKSAVGLAPVKKSRHADINIFTVASGLLYERFASIMMLSVMKHTKSSVKFWFIENFLSPTFLKFLPQMAEHYGFEYELVTYKWPAWLRAQSEKQRIIWAYKILFLDVLFPMDLDKVIFVDADQIVRTDMKELVDLDLEGHVYAYPPMGDDREEMEGFRFWKQGYWKNELRGNPYHISALYVVDLQRFRAQTAGDRLRGMYHALSADPNSLANLDQDLPNSMQQQIPIFTLDKDWLWCQTWCSDESLKTAKTIDLCQNPLTKEPKLSRARQIPEWDSYDREIAEFAASLGASELGGSVDELAGTLEKAQGLKDSDAPSSSDDATMDSAEEEGLKEEIAHEKQVQAEQDEALEEILADADAPVSFESDRPESKRKTGPADSQKGGVKADIKADAKDPRQHPADGRAAVRDSVNEEEVEVLVTYSDEPGAVWEPALKRDNTEPDAEKEEGEQTEEVVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY00</accession>
    <name>K1VY00_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY00"/>
    <dbReference type="STRING" id="1220162.K1VY00"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015676_1_0_1"/>
    <dbReference type="InParanoid" id="K1VY00"/>
    <dbReference type="OMA" id="LLELNIW"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="609" mass="68209" checksum="A71D80AEA49D58D8" modified="2012-11-28" version="1">MTKNTDVPAGSGTALEKATRWFDALQNALDGNDTARASQLFCKESYWRDLIAFSWNLTTVEGPEGVKDLLDNTLPQAGPTKWKATEADEADGVVTAWFEFETKYGRGWGINRLKEEDGQLKSWTLITSMTELKGHEEPKGTRRPMGAEHGANKHRVTWKEKKELEEKNLESGEESPYVLVLGGGQGGIALGARLRQLGVPSVVIDRSSRPGDQWRGRYKSLCLHDPVWYDHLPYIKFPDNWPQFTPKDKIADWLEFYTKVMEVPYWSNTTAHKATYDPKEKRWEVRVTKDGEDLVLRPTQLVLATGMSGKAKIPTFPGQDVFKGEQQHSSQHPGPDAYRGKKVVVVGSNNSAFDICGALWEHDADVTMVQRSSTLIVKSDSLMDIALGDLYSERALANGITTEKADLIFASLPYRIIHEFQIPTYQKIQEKDKAFYDKLASAGFDTDMGDDGSGLFVKYLRRASGYYIDVGAADLVADGSVKLAKGEVSHLDEDGVVLASGQKLPADLVVYATGYGSMNQWAAELIDQETADKVGKVWGLGSNTTLDPGPWEGEQRNMWKPTQQENLWFHGGNLHQSRHYSLYLALQLKARYEGLDTPVYRLQESYHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYE4</accession>
    <name>K1VYE4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYE4"/>
    <dbReference type="HOGENOM" id="CLU_855777_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYE4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="334" mass="37546" checksum="6F8FA90FF5FB6C1A" modified="2012-11-28" version="1">MVVAVADLATLGAHGLRSVTIVATDCCASLSLRNISPSAHHSRPVKVCIDAASFPHIFESILDLVYEAGDASTLRALRLTSSSVKEQVERRICHHLIVRPGRVYTKHVGLRNREWNAIKLLDVFDPFTPADVTLSSPSTIRFFARHSSADQPWVPDADTVIHVVDVSRMRPTALELSCICAVSPRFKRTIVSVRYGARLICSVYYPYKPVEFSDDPEMEVVLMFHPGPTRRSVWPTTTKPNQPLHIVIEQTLGLLRRSENLRVTVVGSESWDVNWFDGTNTRWPMPESTASLTVSDLWDICAGWYESDTSRLAFLTLADFRDREPETLRLCTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYL7</accession>
    <name>K1VYL7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYL7"/>
    <dbReference type="FunCoup" id="K1VYL7">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYL7"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="InParanoid" id="K1VYL7"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="755"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="582"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="996" mass="110638" checksum="5583AC5B8EE0B9EC" modified="2012-11-28" version="1">MATSMRGLTQYISDLRACRVRELEEKRVNREMAHIRQKFKDGNLDGYQKKKYLSKVVFTYILGYKVDIGHMEAVNLIHSNKYSEKQIGYLAITLLMHENSDIVRLVINSIRKDLEDSNEINNCLALHAIANLGGREMAEALADSTFRAMISPVSTTFVKKKAALTLLRLYRKHPSVMPVQEWAERIVPMIGERDQGVAMTATSLVTAMAQDHLEAFAGCYQHAVDRLDKYYPPPDNPEVVEMVNGLLQAIIDMSQETPRNVQHNNAQNAVLFEAINLAIHLNPESKVVSNASVLLGRFILARETNVRYLGLDAMAHLAACSTSLEPVKRHQDTIILSLKDRDISVRRRALDLLYSMCDTTNAKVIVGELLKYLQVADYNLREEMVLKIAILTERFATEYEWYIDTILQLISTAGDHVGAEVWYRVVQLVTNNEDLQPYASTAVYRHIKKAQCHENMVKVAGYILGEFGHLIANDEGCSPIELFHALHSKINICTAPTRALLLTTYIKWVNLFPEIKEHLVNIFRRYTHVLDAELQQRACEYLALATRNDNDELLQAVCDEMPVFPERESALVNRLHKRGNAAQDKRTWVIGQQSENRDKFAKQFSKDSTSAADDETVPVPPPKPQMSLSQPQPQASLSVDPQPSGNLTPQTPSASEPMMGPGPSSQSTMLSEDIMTSLAGLDMSSPAPEPASAQQRLLPEQQQFVSEPTGGAAPLSTLTSPTTPDDLQHTATLGGVNPALLHGLTTGPNVEKWLERLSYASEGVLYEDKQVQIGIKAEYHGPLGRIALFIGNKISTPFTSVSARIENSEPGLSANFHDTPVTRIEGLAQIQEMIHVEAKGVFTSPPVLRFTYLAGGFTTLVLKLPVFLSKFIEGVQLDQAAFFERWKIIGGPPREAQQIFPIKLSEAGEIDTQRNEKVIAGQSMSVLRGIDPNPVNIVTAGVLHMTSGKVGILGRLEPNRDAKLCRLTVRSTNEEVSKECLKLFSKPINADVAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYT6</accession>
    <name>K1VYT6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYT6"/>
    <dbReference type="FunCoup" id="K1VYT6">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYT6"/>
    <dbReference type="eggNOG" id="KOG1407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532103_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYT6"/>
    <dbReference type="OMA" id="MAIRHSA"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="463"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="543" mass="57346" checksum="8084292AF7D5EAFA" modified="2012-11-28" version="1">MATDSEKIDGFLRYDAFPSRSFSARGLPVRGGNAKPVRSLAWSSDGKRIATGTEGGGLRVWDVRPGGGVEGTGTGMKSPHPASNVTIAVAWSPTEPTVLASGCKPGSSSSGGYVAVWDVAGGVSPLAKFKIPGEVLHIAWHPDGEQFAAVCPRQARDEVYFFQKKNGVWEQRQDIMMGGAGIDLIQEINSLRFWKGGDAVLCVSNDGSLNAWWYPVEERAPPPLSPSPEAEVEAEAKDEEPPAKKPRLDSKEGSAEKPEPEAEAEAEVAEGEGEADGEEDEVKRTRDEPEAATPAAATPAEGAEVAEGEEGEADEEKPEGEDARAEGEGEGEEENPTIEVTAPDAKQDVDMATPGAATPAAASTAAPSPAPDHPSPAPAPAAPSPKPDGAAAVAAARAAASRELLRRKHKQLAPCYRQLLSSPSSLLSLALHPQGKYLAVGGQDARVSLYSARDWLLERTYHQPSGAIRHIAFSPDGELLAVGGDDPFIYLIGVWNKQTVQKIPVHGVVNGLAWNPVLREGKCSLSWSTKSSTGVVWYLANQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYW4</accession>
    <name>K1VYW4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="20">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">A1Q2_00962</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the PanB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="20"/>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYW4"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237687_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYW4"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="22">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="24">
        <location>
            <begin position="141"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="23">
        <location>
            <begin position="657"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="566"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="852"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1344"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1440"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1457"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EKD04732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1818" mass="199811" checksum="81BBAB1EEEE1E837" modified="2012-11-28" version="1">MKVLCVAEKPSIAKSITAILSENNFTSRQSGHQYIRNYDFDYNLPPPLGGGRGTDFTVTSVLGHLTSLDMKRVETNLKNEARRAQILMIWTDCDREGEHIGSEIESVCRRSNPNITVKRARFSAIIAAQIHQACRQAGNLDENQAKAVEARTELDLRIGAAFTRFLTQTLQIRVPELGDQKLVSYGPCQFPTLGFVVDQYNRVQSFVPEQFWYISVTCERDSDDGETFKVEFKWRRNHLFDLDVAVLLSDFRKPLPLTTVDLQQSGSRLLGMTPKRILDKGFLSYPRTETDQYDKAFDFMALIRKQELNRELLDGAFQTPRNGRKNDKAHPPIHPTNGAQGLEGEERKVYEFVTRRFLASCSKNAEGMQTTVEIEIAGEYFHASGVIVKARNYLEVYPYDKWNSNPIPDFQEGEQFVPDECMLKEGVTTAPNYLTEADLVGLMDKNGIGTDATIADHIAKIIDREYVLTKTQQKTKYLVPSMLGIGLVEGFNAIGFDRSLSKPHLRRETEHRMQLICDGQQRKGEVIDLSLEEYREVYVKAKREFNTVVDSVKNYLHGEGEAQEALRAAARGGRGARGGTRGTRGTRGTRGGRGGGRGAVPRGSPDYDDDDDDDFGGPPRGGGAVRGSSTRGPGTAPAPTRGTTRALADGDNEPPCCQCGTPAVQRTSNSAANPGRQFYACPKPRDEQCGFFLGAPGEEGGHTVKRPEVQLEEEATGAASSVAKRATGQASVPTKVAAHKAVGQTTRLAELPGQDASSAARKDTGPAIARTSRTVEGTLVVPHAVAAALAVGPRVAAVGDEGVAAVEAEAEEMPKEKQSIVDEPPHTEPILDPSFAALMNDVNMSLKRAKQGEKSYVAEKDITPVPASEQPAEVEEGEEDAQSPRRPPRRSPAAMFGTKNIGMIVLPDWLIEGVQNEVEQVDNRRIVREKYLEMLEPKKEKSDKTNSRNTEQHALARAAAFLPAQCAAVANVLRELRTRVGDIKGPILETTDGIAPGLWAATEELGVDAIREFTLIQRTRWGLALAERLAQPLAIDVNLDEMDFKRDISFAGLPQPPQVAMSTFMMSMLPTAQSRRDHLKQLLETDAEHIVIVDRGSTEVWEAMDAARTFLMEHSTPEHPLHITAPCPHQFTCPRAGTREACSFIQKVQRPPFLRRTKHAKRGEENITYSYLIISRGERPKSTATAGRFGIVAAELEAKKKAKATKRPELVPVEGGESGAFEVVNTAAMEYEVPPAESLDDPALVQSLREQAYSWPRLIAQPMKRSGHVVMDMCAPSGNLERRRYAKSTGKQEYYDARRTAWGDLFPHESKAKIEVRDRGIIHLKKTLSEAELIEQERDIKRKEKAKREAAKLAANTGKAPPPPPLEPAEPAQSVYAEPRTVKGKNGLAFESTGDPELDALYKQLGIAPVVAEPVMGSPEGMTEEEEMEQELERMFGTFDPLPAEPEPMPTSKRGRRQAEAELTDVRFSRRGRQRRPKAWERAKERGEREYSTSAFALGRRPMSTLARPAVSQTGLGVQKRFMSARPAELKGRPKLTVGALQKQYASGTPISVLTAYDYPTSRLCADAEVDIILVGDSLAQVALGYQSTTELTLSEMCHHIRAVRRGSGSSFILADMPFGSFEASVEEGVKSAVELVKAGADAVKIEGGAETLPLVRRLTSFGIAVMPHIGLMPQRAASTGYRVQGKQASAALDLIQLARDFEAAGAFGLLLEAIPHQLGALITAKVGIPTIGIGAGNQTSGQVLVLTDLLGTYGFDADCKAPKFVRLYAQSGQKESDAVRQYIADVRDRSFPKTGEETYTMPEKELGELRRLVDEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYZ9</accession>
    <name>K1VYZ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYZ9"/>
    <dbReference type="STRING" id="1220162.K1VYZ9"/>
    <dbReference type="eggNOG" id="ENOG502RX7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585514_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYZ9"/>
    <dbReference type="OMA" id="FISSGCC"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="467" mass="50602" checksum="DC47FC3141377896" modified="2012-11-28" version="1">MWAERAAARYPPASTSTAVDIPDPVSQQPPVSDADPNHIIPRTPPSSAALLDELAQLLPAATAAGQDLDPALVRLLCPPLIPQPAAQYTAFTASQTSLRYFQHYLTVIMPYQWLFERRALADLVAPLAYADEAVFESLVALGALHVGSRRALVGGAVDTDTAQQSLQRSIASMAALPPERLGRHETIVAAMSISSFYLFAGGNRSGWPNAVRTCRACLSAVQHLDPGELGHLLSPLAWTDILASVTEGRASAFISLYRRLLAGDTATDDRYLRETVMGCDSTTRLAIAETVALSEWKDQQSAAGCLSVRELLHRSSAIERLLSEREAREHFDDPARRLVADVFYHGSRVLLATVVDGCYPYTAELASAVADVLLSLSALDAAGVAADRALVFPITISGCHAQEPQRAAFAARFHRNRLGPDADFGNTRNALRLMHAVWARRDAAPPGEEVHWRRIMHELDPAGLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ10</accession>
    <name>K1VZ10_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ10"/>
    <dbReference type="STRING" id="1220162.K1VZ10"/>
    <dbReference type="eggNOG" id="ENOG502RBC7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824355_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ10"/>
    <dbReference type="OMA" id="HNDREYR"/>
    <dbReference type="OrthoDB" id="2575566at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="37043" checksum="801DF807FB311485" modified="2012-11-28" version="1">MAGVQPPFSAEALNRYRLTHNDREYRPLIRRLNKTPTVDGQEDGDKEMLHLDVEKWRLHVERLMASAKSMERQKREYERKRDETGKLAAIVSGGKLTSVSQTEALRAKLAEETALLQAKQTERARRMKCDEVARKITARGKTRVELDAQIASLQALIVEHRASYEAVLGVAQQRADTFGRIAALVDECRGLKLALSEEDAAAEKLVEQAEKELKAEKVKEKTEKTKLSAQTLPFQPSAATLSAPTSRQHSASPGPAHGGAHAHPLPARPVRSGRRAAASHAPHSASGLPPRPVSGLRNVRHMHSGPPGLEDGELGEDDGAGQKRKAEEPHGRSTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ88</accession>
    <name>K1VZ88_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ88"/>
    <dbReference type="HOGENOM" id="CLU_1846505_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ88"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="139" mass="15235" checksum="C885F952714C68D9" modified="2012-11-28" version="1">MRATLRLAANVDRSAFKQALRNAQQHQPAPVNKPLRPAKPLMEKLTGEPAPKQSLSDRQAAAAKGKNKSIIDSFRSLPSNQRILVGVAFGAVAIAGLFWDRTMEEAELKQEEEYGFERVADEIAKRKAEAGNAPAARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W025</accession>
    <name>K1W025_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain type dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W025"/>
    <dbReference type="STRING" id="1220162.K1W025"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="K1W025"/>
    <dbReference type="OMA" id="CYATNST"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="253" mass="26329" checksum="1A3ED4F1BAD976BB" modified="2012-11-28" version="1">MSSKIEHPGHPKESLPVTQAVPVLDLFKLAGETALVTGAGRGIGAAIATALAQAGAHVLLAQRDISNTATYDSIVSQGCKATLVQGTLSTPEDCEALWSSALAASDNGIQILVNNAGTGGWSLAVDEKPENWDNTMNVNVNALFHLSRCAGRHMIEAGKGGSIVNVLSILSFLGGYGMSAYVTRGSTWADNRNLRHAQDKELYEGRIKNIPGGRWADPLDYAGPAVFLASSASNYVTGEVLIVDGGAIAKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0J9</accession>
    <name>K1W0J9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0J9"/>
    <dbReference type="HOGENOM" id="CLU_158829_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0J9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="131" mass="14318" checksum="F2DDEE6948943B48" modified="2012-11-28" version="1">MSQTTTQAPTIVDLGGVVRVSSLKRAEVKRSPSSSKSSKSAKSSKPASPAPSNMRPSSAPRCLDPHFEDAFLRLIQDRPQQKPPAGQFGGWKQEWPVFWEGAGLAPRVRAAHGNGYCRGFQILRAFGLLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1W2</accession>
    <name>K1W1W2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1W2"/>
    <dbReference type="FunCoup" id="K1W1W2">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W1W2"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="InParanoid" id="K1W1W2"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="166" mass="18015" checksum="22A654841292DB3C" modified="2012-11-28" version="1">MPERTPEPQYVTIDTSVGSFTVELYTAHAPKNFAKLAERGYYNGVIGFMIQGGDPTGTGRGGTSIYGERFADELSPELRFVGAGILAMANSGPNTNGSQFFITCAPTPFLDGKHTIFGRVYSGMKTVQRLEAVRTDGNDRPLEEIKIHKARIGKDLAPGDRLSLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2F3</accession>
    <name>K1W2F3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2F3"/>
    <dbReference type="STRING" id="1220162.K1W2F3"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1046572_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2F3"/>
    <dbReference type="OMA" id="CTFITAR"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="28801" checksum="27E19963CE655BB3" modified="2012-11-28" version="1">MLATAIPSSAVRPPASTQLGTSPEISLGADALNAVAQYMAESQVLEEMAAAYLAADELAREAREEEAQQKEKTDSALSMQVFPEQWGMSQFWNDAATARTLAEECVRQAKGGTIQKMGVPNRLLLLEYDSRFAVFSEFRTYDYARPHNVGSMSRAQIKEVKAAVVLLDPPYINSDCFSKTATTARALSTPDTRIIACTGWKIRDTVQDVLGAHMVRFRPGHSCGLATTFRAYVNYEGEGLYEADPDPENGDNDGTAFAGAGGVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2W8</accession>
    <name>K1W2W8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2W8"/>
    <dbReference type="STRING" id="1220162.K1W2W8"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="InParanoid" id="K1W2W8"/>
    <dbReference type="OMA" id="CANELNW"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="330" mass="35206" checksum="DE3C9A2E3CC9BC7A" modified="2012-11-28" version="1">MSLPTESKAVVQPDPSSTKLESTTLPIPKATESEHLIYVYGTSPCLGELGWEKNFPALFKERKARVPGTEGAGVIAKAPGGSPYKPGDAVMWRNNAWMWGSLRGVTAILEENIAPKPECLSWSEAAATPLSTLTAWDGVFTHGPLDPAALEGDSAARKKNEGYRILITGASGGVGGWAVRLAAAAGAHVIGFGGGAAADGCKKDGAEAYLDYKQDDLAQLPEKVDHIFDCTGRDTEKGWSVLRDNGSFVSVCVDPNSTKPEGKPVKDAKWFLVEPSGKNLARISKLIQQKGWKPVLDSVVPYDQFQQAYDKVDSGKTRGKIVIAVHEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2X5</accession>
    <name>K1W2X5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2X5"/>
    <dbReference type="STRING" id="1220162.K1W2X5"/>
    <dbReference type="HOGENOM" id="CLU_641214_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2X5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="428" mass="46966" checksum="8CD80D5003DB3DF7" modified="2012-11-28" version="1">MIRSKFQACTVKWLTGVEASTRVRGVSRAAVSPRIRSQIFQRSGPYHLSDALSASEKAQVIGKVSVFEEAMKGDKAALQEVIDGAAVLPSSLASMIDRYSPVPGEDGAIDELVANSAGFLRVVEQYEQVWNSLRARAVADFTGRITEKSATEREIWRLCVRALHRAESQCDRAFGHQPENSPMGVLFLMLVHWSRHGVVDMFTGVPFDIGGSPHSPRGFTMMAHQVHNAPFNLGFDRPYPTDLSQYDGARFLPPPVVIEIIRSARTFVGPLLQNLGLAVSTTEFTFGDSLWSELEHNGLADFEIEHFYDVPAERGLAIRDPKSQYLVNATHSDLPEGSARDLVMTNSEHELQDLLRAIGPVSGGRKTDLAIRIQQLSVLEDELLDPGGVGKSSRMSADQEGSSSKVASERKETHSQPLLAGSSLGRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6S4</accession>
    <name>K1W6S4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6S4"/>
    <dbReference type="FunCoup" id="K1W6S4">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6S4"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_4_0_1"/>
    <dbReference type="InParanoid" id="K1W6S4"/>
    <dbReference type="OMA" id="CCGCKEW"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="117"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="667" mass="72376" checksum="6C3638838C15D146" modified="2012-11-28" version="1">MTAQTAHATPKRALSRRPSLPERTKMTMTDLPPADAQKPDSLAVDDVFDQLKATGSLEAAARRLAEIAMREETLPKVVQRRQAWEDDPEEAEWQQQQAEEAQGGAARRGEEEEEIEHLQQVCDGLWVGDLVAAMDGEGLRERGISNVVSLLRPRLNFDPEFAAYTIEIDDAQDTDILQFLPSTSAWIRDALLKRQGTPDEERDPAIEPRAPETNPGGVLVHCQAGMSRSATVAAAFLMNELELDPEDAVQVVRDARPVVDPSETFWHQLGIYHQAKKRVTMKDRTTRQFYLERNAGMVLNLGGRPSMDHMAKYPLSPTASTPQTPAGATGRRKIRCKMCRRNLATREHMMDHILAQSGGPATRPATPSAFALPQPLTTTEDATFQPLERSNSVSSVINPLTGLPGARSRRASNASSRRPSLGAMSAISDGTTRSRSRSVLGNDGQLTMSRRDSSGSATGPSGLAPMTSPEAVKSEGGRPPTPPLPSDSKKEEKEPKEHKEEKKEEKKGPGGRPMLDADALAARLPPQLAALRAGFSATSNLSSPIASSPPSSPESELPPARRRPSNLGMTSMPQPLTPAALSALTQAHAQQAAQNGPPILTNNKCSGYFVEPLTWMEPALNGQVSGKLFCPCGAKIGTFDWAGVQCGCKEWVTPGFCIHRSRVDEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W748</accession>
    <name>K1W748_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W748"/>
    <dbReference type="STRING" id="1220162.K1W748"/>
    <dbReference type="eggNOG" id="KOG1578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_3_2_1"/>
    <dbReference type="InParanoid" id="K1W748"/>
    <dbReference type="OMA" id="GMIFTHR"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="218" mass="23085" checksum="C90472B7E9C2F6A4" modified="2012-11-28" version="1">MPSVSDFPELQALLATNESWAKNTAENDPELLPTLATGQKPGFLWIGCADSRVPETTVLGKKPGDVFVHRNIANQFHLDDASANALLNYGVLHVGTKHGAFYPSAVDPHRKTELTPVIVTGHTACGGCIAAHSLPADTEPSNALLEFLGPLIKLRAGLGADATVEDLMVANVKQGVENVCNSAEAWAKGKDVYVHGWVYDLASGRCHDLGISRGPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7F8</accession>
    <name>K1W7F8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7F8"/>
    <dbReference type="HOGENOM" id="CLU_1518918_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7F8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013379785" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="19098" checksum="E75B8C13C019907E" modified="2012-11-28" version="1">MLFSTLSLFLAAVSAAPIKRSECVPNYAPDGTYIDEGCGIVMRANGGLCMRTDYDTQPSAPVYLEECLAGQHGRSGGRWSVSLGDTKLRNMEAATPDYCLTANEARTLVVAQRCEEGNKSQNWETSLPWGDSQDARIKLKGEDVCVQARKTGKGDQIELAKCGCLTDQIFDAPGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7W7</accession>
    <name>K1W7W7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA recombination and repair protein Rad54B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07937</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7W7"/>
    <dbReference type="FunCoup" id="K1W7W7">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7W7"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="InParanoid" id="K1W7W7"/>
    <dbReference type="OMA" id="YTEHERM"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="280"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="595"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC97738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="833" mass="92742" checksum="CE1E5911FECF839F" modified="2012-11-28" version="1">MLRRVPSKKNGDPPVTSATSGGFGIVSKPFKAPSALGSTRTLAMPARKRKQVSYKEAGAGGDDGDSDVPTKKMRFEMGNKVYENGVLGDMAKWCTRKFPVFAPKESTTVFSKSFAIPVMTNAKTSEKIAHPLSHASLGARPHPTLAPRPLHDPMADHAIVLYDPTIDDKPDPEEVAQKEEAAKKEENRGPHKSLKAILGIEDKTKKKVVKVPVVIDPRLSKVLRPHQIEGVKVSLGGKALTVSSCIDARRAWLRTMLGVASWPTRWVLVSGQWQVTADVTGKTLQCIALLWTLLKQSPVPGKGTCEKVVIACPTSLVGNWANELIKWLGPGAVNPLVVDGKGGKAELIPAVRRWAAASGRSVTLPVMIVSYETLRTLKTELDGCPIGLLLADEGHRLKNADTLTFQALTALNVQRRVILTGTPIQNDLSEYFALLNFANPEYLGSRAEFKKNFELKILRGRDADATDKEKEESDAKLKELGGLVSRFIIRRTNDLLSKYLPVKYEHVVFCNPSPLQSSLYNHFVNSKDVQRLLRGKDSQPLKAIGLLRKLCNHPELLNLPDDLPGSAQFLPEDYAVGRTGRDRSFNCQLSGKFVVLERMLDHIKNHTTDKIVLISNATQTLDLMERLCRVKKYGCVRLDGTMSVNKRSKIVDRFNDPEGKEFVFLLSSKAGGCGINLIGANRLILFDPDWNPASDQQALARVWRDGQKKECFVYRFMTTGSIEEKIFQRQCQKQNLSACVVDEAEDTARHFTQDDLRQLFKFHTNTLCDSHDTYKCKRCRDGKQFVKAPAMLYGDASTWNHFPNSQLGQMHDDLLRAELGFPEVSYVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8Y1</accession>
    <name>K1W8Y1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W8Y1">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8Y1"/>
    <dbReference type="eggNOG" id="KOG1953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002231_2_0_1"/>
    <dbReference type="InParanoid" id="K1W8Y1"/>
    <dbReference type="OMA" id="EHSRDRM"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="290"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="493"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="788"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1464" mass="158869" checksum="57F3711DBB65967A" modified="2012-11-28" version="1">MSGGRESSPLSDPIALARLQILVVPVHSSRESQPSNPVRLSTPVFDYWSALFRNRQSLRGDEVVRQREFGHKKGASDARERFFPSASGANMSRVAGANHVHLSFPAQPPPKHLYPLSLLRMTAFPLVIIGVGLDDDGNDMDQNEKEAAWAQAFNRTLATFMPSTSAFPLVKRLMLVPPQLPMPGSSRNSRKPKQSNDPLISYAPLDGGDNFVADVLGETTANDKAAALESQSGMSTLSGTLLPSLSSTLGPASASGASTPVVSSKAEARGSLPGSSSMPLMPSANMSQPVSRALTPGGRPASVQPPSAPPIQTSAISPVAAPQPQSANPFRRSTAGLTSPFHRSSATSSPSNKDSGKDAAMAKYTSAPLTGIAGGRLIKLLGDMYLVTGMYADALKCYEDGAERCRAVGDVLWEALAREGRAVAGIIEAWEGRDGSTLSTPFPSSPVPVEILSHYLSALACLSRAPLPFPEATPNGPAGAQTPHLNLSNVGTGEGLLAWLYASMCLRISRFVLMIFAAGGWGSIASSALVSNTLPRTFPALLNNPNDPVKSRNRRLNLVDLASRSEISRQTIFGHAQVAIGPFRRAMTAADQLAVFVEVVWIARWLELERKEASATREIVKLLAMAVVEGREEHRDQQTGAVMSPTEMPGSSVNQAVTIRRKESTDGNAGVMALIERVCAVFGIDLLSFTDEQTEPVLQAAKELRPTHFGWPELQVEIMKEAIAVSEALPDHPAAVRLCVSTLHSLYAYLSPASQGHLSKLYPKALSTMRRRAIEFGSVPWWLPDRVVLSVEISSLASNRVPLEHTRAEITAQGKKDPFLYNPRVKAPELGKTLLVANEQVEVFVTLQNVFAFDLEVQNLSLLTAGAPFITNPLPLILPASSVQTVRVTGLAPNAGSLEIRGVSVRLMDGSSAEFLLPVVDGAGARRDSKHRSRLQAEAAKTKQSGLDVRKSLMFTQSDGGLPPLPTKEDEHRWLECNVVEEQPLLWIKKTSLSHGTVMLFDGETSVIRITLENSSSVPVDFIKLSFDDSVSREAQAMMSEEISPQQAFDLDYDCTQRPVFTWDKNSNVHIPPGGRTTLQIEVLGKVGCTDGSIRIDYGFINREAEDPANVFYTRRITFPVLFTVYHTLEPHALDIACLRSSSESQEKLRKRLANGTPRSSTFGTSGDEVLRRALAQDDDNMVLFCLNVRNVYSVPFEVALSSKRTASPSALNPDSESSSDLVVTRLVPPGATERLVLPIQRQTLSDDERPIPTPEGRQYVVEKSKMTPDQMKRQRELFWYREKLLDLIDISWREPSSLRRGRLSLRDQPINPAHLDALRRDQLSISLDVQPRDGKASFTAMDFVDLRINIVNRLERKLRAYVRLEALPTSSNDASWSQPPAPTPRRISSLPAAPMPAPKSIAFDGVLGAAMPVLEPGESATHTVGAVLLASGSFTFRAAAEEIADRPDPPPVCFSPSVSVDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9I2</accession>
    <name>K1W9I2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Voltage-gated chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9I2"/>
    <dbReference type="FunCoup" id="K1W9I2">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9I2"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="K1W9I2"/>
    <dbReference type="OMA" id="WRILFVY"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="110"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="602" mass="65679" checksum="B61DA5C5C0B953E8" modified="2012-11-28" version="1">MSGFNDGYNYHSNSNPNDGYAAQHNFAQQPAYGHPHQQPAYGAGSHSSDEGPYKEPAAPAYDGGDGGYGRFADKEKGLVAEEPVSTDCGDSDYADIDPNSGVKRGLKTRHLSMMALAGIIGPGLLVGAGGALAKGGPASLLIGFGVIGIIAFSIMQSLGELTTLYPTGGAFTGLADRFVDKAFGVALGWNYYIIWFCVLANEYNVICSIFVEWGPQVPLWGYFLIFWFAFLAFQLLGVEAFGEAEFWLALAKLLGLVAYFIFSIVYMSGGVKGADAIGFRYWHNPGPWVHGFRGVATVFVFCSTFYAGVESIAVAATETKNPRRAVPMAIRQTFWRILFVYMGSAFFYGVTCPSNAEGLIGGSGNKALQSPMTIAIQQAGWYGGWNLVNAFIFVTCLSACNSSIYIGSRTLLYMGQNKKAPKILGWTDRRGVPIPAILFTNACGALSMMNISTGAGKAYQYIVNLSGVSTFLVWGGISFIHIRFRAGWKAQGHSPDELPYKSMLYPWNAYFGLGACIFLALVQGWTSLSPFVAGDFVDAYILLPVFFLIMILYKLIAKTHWWRASEMDLMSGRRNDLDDKVATAEGAMPHESRWKNKLRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAJ7</accession>
    <name>K1WAJ7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_07018</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAJ7"/>
    <dbReference type="FunCoup" id="K1WAJ7">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WAJ7"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="InParanoid" id="K1WAJ7"/>
    <dbReference type="OMA" id="QLPYFCN"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKC98658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="491" mass="56085" checksum="295C8D07488DAB9D" modified="2012-11-28" version="1">MANGNGTTNGANGVRQRKKTSEVVASGESTQIMNAIPTAYGQAMDKKLDEHQTYEFGGPVGVTAMMLGFPVLMYYLWICLWYYDGALVHPSSLSDVGPFLQRMWAHCVDGAYPTAFAWGTYLGLTAIELFFAWVMPGVEQHGLPVPSLGYKTLLYKCNALWSWYATLILAGVLHYTGIYRLPWIIENFGGIMTVAIVTSYTISATIDILARTMHYGGAPLRMSGVAVYDHFMGVSLNPRLGPIDLKMFAEVRVPWVLLFLISLSGVVKQYEDLGHVTYNMFHMLLATGLYINACAKGEQMIPQTWDMFHEKFGWMLIFWNMAGVPFTYCYPTIYMVRADPSTYAFPTWACVAMFVTLLTCYYIFDTSMAQKSAFKMQQQGEYKPRKAFPQLPWSVVENPTFIQTKHGNKLLTSGWWRYVRKPNYSADWIQALTWGLTAGFNTPITLWYPIFFLAVLTHRCGRDFEKCERKYGDDWDEYCKVVRWRFIPYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCD7</accession>
    <name>K1WCD7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCD7"/>
    <dbReference type="FunCoup" id="K1WCD7">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WCD7"/>
    <dbReference type="eggNOG" id="ENOG502QUUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_1"/>
    <dbReference type="InParanoid" id="K1WCD7"/>
    <dbReference type="OMA" id="AYPENDA"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="9">
        <location>
            <begin position="429"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="774"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110553" checksum="B66F5A568943A6BA" modified="2012-11-28" version="1">MLSRLGPRARHCVIGPLALPRGTPVSFGRLLRPKYASSRSGGRRKKEVLAFEDLPVSATTLQEDLTIGPVEPYLESSKPKRKRKSKSGESPGDDVVRAEYVDISPEEQAEYEAALKAGEIPETPLSKLVWLNWKRFPDCILLTQVGNFYEVSSLLGIKLTSKTYKTGQFPFTGFPIHQIDKYLKLLVQDLGYTVALVEEAKDPLQLRDPRDEVKRKVTRVVTPGTLVSESWVSGQESRYLLALAVGAHAKGDAGLPVYMAYADVSTGEFFTKDTTVNDIEDELTRISPKEIVLDSTYRDAWLQGTEAVDLDADVGEFLGLLRVLGVHVSFASTGEEDTTLQRRSAPKPSSALTLERRAITLLRRHLEYALRDSMPAMPTQPEEFNRESEQHQMHIDAPTLQALEIRHALRPGGLMPISTIPSHLRSPLSVKGTLLSVISRTVTDSGQRLLRRTLSAPSTSLPHINARLALVASLVDNEDLRLRLREQMRELSDVMRTVQKFRSYQGDGSDVWDVARWIRNVEQILARIHETVREKRRKPVPTGEQAEGRERLRQFVEAFRPLSELADTIEGAIDETALNVLQIADESDPEPSPRGTKGEEEDRKRAERERALCFSTELSDLHKQIERLKAQRDKLEARLREEMAAPTLSLGQNVRGAFVVNVKRKTEIGKLDRSPDFYVMSETRASKTFANNELEVAHSRALNRLRAIVIEHSGTVQHNAELVDELDVSAGFAQAAVELNYLHVEAGRHPSVESGLLAASRAFTPNSTHMTPSAYLHVVTGPNQGGKSTLLRQTAVLAILAQSGSFVPADSARIGIVDKVFSRIGARDDLYRDRSTFMLEMVETATILKSATPRSLVIMDESADARIGRGTTLNAGISIAYATLDYILRHIGCRTLFATHYHELAHMLGAPRSPTAKGDVRPGVAFFCTDVAVDAASGAFAYSYALKPGINYDSHAIVSFVRGGVADVQKAAQLAGMPADFLEIASETLKRLDATKPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCX5</accession>
    <name>K1WCX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exo-beta-D-glucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCX5"/>
    <dbReference type="STRING" id="1220162.K1WCX5"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_2_4_1"/>
    <dbReference type="InParanoid" id="K1WCX5"/>
    <dbReference type="OMA" id="AWPNLHW"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854719" evidence="4">
        <location>
            <begin position="19"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="8">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="234"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="6">
        <location>
            <begin position="691"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="7">
        <location>
            <begin position="783"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="889" mass="98895" checksum="F7546BDD08A4A549" modified="2012-11-28" version="1">MITTLLLAAAGLAQVATAGDADQQPHLLTNGPGQSAAIPRWDIQSTAKVGTDLGKLSTTGVDTANWHHTTQSRCTLMGCLLDAGVYKDSELWFSENLKGFDGSLFQVPWVYRNEFSLPPAKDGQHFLLETNGITSEADIFINGNQIANSTFQAGSYGGHVYDITCAADEKNAIVVQVHPTNYAYDLAVGFGDWNPYAPDNGTGVWRDINVRQTGDISMGPLSVLIDLPLPAGEKDATVTVRAEAKNRGRSDVSFRANAAIADPSGKAICHLWQDLKLKAGESRVVEFKQTVTQPQIWWPRQWGGQPLYTATVDFTINEQLSDKRETTFGIRSVTSAINQYNDTMFTVNGKPFQVIGAGYNADQFLRWDGRYFADIVEYMFDMGLNTIRLEGKMEQPELYEIGDRAGLMVMAGWECCDKWESFEYNHDLALNPPPVWDDREYGIARYSMAHEAQVMQPHPSMLTFLIGSDYSPDERATRGYIEALQQAGWQVPIIGAASFREPAVIKSGMKMQGPYDWVPPNYWHDLPDTASLQDTRFGSSFGFGSELGAGVGTPELGSLRKFLSDSDLDDLWKNPDKGLYHMSNADSQFHDRKVYNAALFARYGKPSSLEDYLMKAQLSDYEATRAQYEGFASRWNAERPATGIIYWMLNNAWPGLHWNQFDKYLRAAGSYFGTKTGARPEHAAYDYVSRDVWLINRSLDRGGKRSVEIEVLGLDGKVLHQQTLSADTEANKARTIGKVEGLDEVDGVVLLRLLLKDGDAVLSRNVYWLGASLDELDWEASDWWYTPTTKYADYTALSSLKPADVATTVTRGKDGYQLTLENRSDVPAFFVSVNLIDAQGHDFNPTVWSDNYVTLWPHEKMDLIARVRGGNAAKVQVKGYNVEAGEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEH8</accession>
    <name>K1WEH8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEH8"/>
    <dbReference type="HOGENOM" id="CLU_027594_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEH8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="471" mass="51874" checksum="2A504529D739E946" modified="2012-11-28" version="1">MYFPPMSHVLGAMVDHPEFTDEVAMDMYGAFDNCTIDIMTESDLMPAFGLATSVQCNALGTVSNGNAKLTLAALNGATILFLGCLLLQEENAVHKLLNMKVTSLVILKDMSDHGLGWLVQPRDASSIISRWLEKTSCDPRAPLTTPQLSLFLTAWISRRGGPMHHGSNAPIDLFSDTGSLDPLQLLHGRIAEDATDMSTNELSRLGHIAHGEFRGCCAGSAAALFLDAIEGPEMDGVRADAPAQRWVEVLLRTALQNGGSNLMTPEAAEATKTYLNNKLGHCPAAASKKLQELDEGIRKQIARFKHDLDREELALFMHHFYRAFFVALTQGRIHDDGVGPLTWGKMPLRVEVGEARLKLLRLPSSDHEHLIEKPERRSLRLHRLFVGAFLLVVVAILAIPGWLWHQDVRPASDLALGRNTRVGLGRLRTSSWPSPEWLVNEGQDVFTLSTVVGDWQKIEDFDGRTGVSDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEJ8</accession>
    <name>K1WEJ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEJ8"/>
    <dbReference type="HOGENOM" id="CLU_1490018_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEJ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="181" mass="19903" checksum="4479233899B051ED" modified="2012-11-28" version="1">MNWNKDGSDSKEKSYQITTPLWLRVIPIGAVGAGILGGELLSLAVRTAFGHKSWHEHGRGWIWVVTHLIPVIVFFINMALTRVSTLAPHEVAVYDSSKGKNMLQYVFTSKHGGPRSLTFAMFSNSLAAGISLPMLWDGRATWLPITICAVSVVAVLALTAVLFTCTARRLNPNETLQQYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF24</accession>
    <name>K1WF24_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF24"/>
    <dbReference type="eggNOG" id="ENOG502RW0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1176138_0_0_1"/>
    <dbReference type="InParanoid" id="K1WF24"/>
    <dbReference type="OrthoDB" id="2563847at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25657" checksum="7DBD5D0CD533C1DB" modified="2012-11-28" version="1">MSESDPLELTSLDTESLLTALLNAEKAIPSLLQDVKPVLTHLKESDPSEEVGTAAKEAVDRYMNTLDFILRQTVYFLRETRSAPNAMRPSPVDGIPRPFAALRGEEVGLGLYGLRVERDTLQLLQQSVESMREQSLRLGEEKKPEDKGEDGEESDLRALTTETAGKLEVLGLDGDTLGVDSSQVGVLEERDQVGLGGLLKGTNSRRLETEVGLEVLGNLTNETLEGELADQKLGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG40</accession>
    <name>K1WG40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG40"/>
    <dbReference type="FunCoup" id="K1WG40">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WG40"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="K1WG40"/>
    <dbReference type="OMA" id="GGQISKM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="182" mass="20471" checksum="90B38B9FE945A0FE" modified="2012-11-28" version="1">MGGSLSKALGKLFGNKEMRILMLGLDAAGKTTILYKLKLNQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVIDSADRDRIDEARLELERILADREMKDCLLMVFANKQDIQGAMSPAEVTEKLGLHKMRDRSWYVHPSCATTGEGLFEGLQWLSQNVKGTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHE9</accession>
    <name>K1WHE9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L24 (L30)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHE9"/>
    <dbReference type="FunCoup" id="K1WHE9">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WHE9"/>
    <dbReference type="eggNOG" id="KOG1722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106411_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHE9"/>
    <dbReference type="OMA" id="QVFRRMH"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="149" mass="16687" checksum="9F33607F3DEB5046" modified="2012-11-28" version="1">MRVDRCDWSGFKVYPSRGKVYVRGDSKTFRFSGSKTESLFLQRKNPRKIAWTQVYRRMHKKGITEEVAKKRSRKNVKVQRGVVGADLASIMAKRTAKPEVRAAARQAAITKAKTQKREKETAKKANRPQGGANVPKVSKQAAKGGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHT4</accession>
    <name>K1WHT4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHT4"/>
    <dbReference type="FunCoup" id="K1WHT4">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WHT4"/>
    <dbReference type="eggNOG" id="KOG0442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002265_2_0_1"/>
    <dbReference type="InParanoid" id="K1WHT4"/>
    <dbReference type="OMA" id="PANIACY"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="735"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="995" mass="111998" checksum="6ADFC8A91819EDC2" modified="2012-11-28" version="1">MSERIERRHIPYLPFHKQIIREICRPQKDDLLIIAKGLGLRRVSSRELMTADLKIVCALLKTYDKKEDLVLVINARPEDEAGIGDELGIMGVRDPGFRILTYEMSISERQAMYKGGGLYSVTSKILVTDLLSERTLCALADETEKIVPVELITGIVVLHSETYVYRLNSSNHQGEARKLGGVCRAPLPEKEPNMLVNLNMNSVMLWPRQNLDLEDLTVRNAQFKNFDTIVYMRLRPVWHKVGMKTKIHVQALAELRDLQTWLLEYDSATFAAYINTLQRQHFLAQKKTFGPQQYLHDWFNAPAAAELVSASQLRVSKPKITIEGTASTLIPDGERHRESNATSNGESAREEFEEEMEAVRELEAARDRPIGGIPETEEDEVMVEVASQMETIPQPRQLEIDDNDEDDELQDVTTVEAPPVFRPVVFSLDADLSSRVETRVRKGHEPVLEEQPKWVLLAKVLKEIEDTIASVSESHANPPFSEGGGRKMMETLFLSNWQYEKNGDRLANPARYTNGANADQLDASKGAMEKKRQEYRRGVPSYKRRRQRAGAPMQMSRKDTIKENTMKELSAFASDDTSLEDAQVQSLQPQDSGAGSGEASSAPPLAENATASLLARAGVLEEEDLMPRFHRWMEGEGLLEDWSTDYGLLAPEDSVIIRPYGGEDDDILLQELRPRFVVMYEPNLAFIRRLEMTYTNSFEEDRFLATVAREAEAFKKLIEDRGGMVIPIFNNDPRAPMTDPISRKTTTYSSRNAGGGDGAPAPQFGALLPSLIDAAGIKVVPATLTVGDYILTPKMCVERKALPDLEQSLANGRLHTQCEAMTAHYETCILLIEFEEDKFGIRTQEDARREAAGRGGDVDEWKDTFYLQAKLTLLALHFPRLRIIWSSSPHESVKILSDLKLNHDEPDEDTAMKKGLSSADGPDSLQPHVENAVAVEMLRAIPGVNGHNFRHVMANVGSIRELVEMDAEQVKRILGEENGTKAYRFLHHDGRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIK3</accession>
    <name>K1WIK3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIK3"/>
    <dbReference type="STRING" id="1220162.K1WIK3"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="K1WIK3"/>
    <dbReference type="OMA" id="PYMAWIC"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="51"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="541" mass="59300" checksum="338E7DFBC0240493" modified="2012-11-28" version="1">MGLSLTRSRSSTEKKEKDQEGRADVEAVVEDLEFTEKGEHGTKRHLSPRVVSMIAIAGTIGTGLFLNSGAALALGGPLGAWLGYTLMGILVGMMMYCLGEMSCYSPTVGAFTEWGSVFVEPAFGFAIGFNYVLMIGMALASELSAFAILIGYWDKDASHIGAYITVGLVVCLLLNVVGVKYYGEVEFFFAWVKVLTLIGLVIFGIIVNVGGVPSNREYIGGRYWRTEPWNDTFMDLKPVGKARFLGFWAVLTRASFSFGGVEAVAVIAGEAHNPRRSIRLATRAVFYRVVGIYVLTMLIIGLNIDQHSPDLLRGVEDSDGTAASSPFVIIAEQAKVKVLPEIINAVVITAAFSAANEDMYAVSRTVLALAKHGGIPRWFLRTSKQGIPIGGVIVAFCFGCLAYLSCGGDGANQAFIWLSNLTALGDLICWVAICYCYTRFYKALEIQGINRRNLTLRGWCQPYMAWICFWFFSIIIFFNGFTSFINGFKGADFVAAYLTLPLVLLAYLWDKIWRRSKVVDLNEVDLSGGPRAALKGTRYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WK48</accession>
    <name>K1WK48_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WK48"/>
    <dbReference type="eggNOG" id="KOG1726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853073_0_0_1"/>
    <dbReference type="InParanoid" id="K1WK48"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35927" checksum="4A1239E0F3C00DF2" modified="2012-11-28" version="1">MSSPGSHSTPAVPPSTPDASFAPQLPPPQLGKLDISNTKSNSNASTAPPSKNVLRKSVSSHPAYKRAQEAADSARRQVGKLRKHPTAVRASDACAKQAQNARDLLGRSEAVVDAERITGIDRLFLVFAGLLLFIALVPANLLGLAAPATTAIVAVRPTYHSYRALTDEKEDVKHLLTFYVALGLFQTVEGCVPTWILDRIPRYYMCKLILLTYLGHPRFKVDDWQKRITKQQSQQQQQQQQQQPVQQPEPLRLHVPYKAQQAYSSSTPTPPCDSPVGRSPSPLAAFGVTVDTQAPPENKYVSSDAVRNGAVKNWVKTSATSAIPRPTMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WN66</accession>
    <name>K1WN66_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WN66"/>
    <dbReference type="HOGENOM" id="CLU_1171330_0_0_1"/>
    <dbReference type="InParanoid" id="K1WN66"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="237" mass="26190" checksum="36BA218B069AA5B4" modified="2012-11-28" version="1">MSVRPGLIAASRVGAPSKALRTQWIRCASDSANSPAPPKRTATVQDADKEIKERQRMMRRLPPGFDFAGAYAPIVFAREPLQVQAEVLVGAHEAHFADGADPLEDVYKEYNQAQARGDITALKNLSMGPALDRATTVAKALSGKKGQWRFIRHVTPPRIVSVRTGPMDMHGKMTATQITVQYDTEQEFTAPKRAPKTSRVREYIVFDRPHEPSGSLKIKDFVKETPIDDPAASEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRU9</accession>
    <name>K1WRU9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRU9"/>
    <dbReference type="eggNOG" id="ENOG502REBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025812_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRU9"/>
    <dbReference type="OMA" id="WRTIVTI"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="681" mass="76511" checksum="6148D5F0F3554DF7" modified="2012-11-28" version="1">MTTPPSPKRPREERERTRETPMKRPKTAPTPPQYADSRSGKDEIPTPALLYHLALSAHAAAHRHYTQAFVPPHVQLSDAPLPLESGPYVSDPHALSTALGLLVAALDMLQAALHTPALSDVEHAAFGAEFAHIGIKVLETVASVQRLRSESVLAIDEKRLLADVDDTIKTSRSPHTRRFKYALELASARFAFMNIKVGRRVIKSALATTPHEAFIHRYQLQLLLLQTLEDSQSNDFFSAAEDLILVEFCHLAHLRALFVLRKWDRLEAAMRECATVFGLPCNPQEVPEVAGSGSSNERLWRTIVTIHYLSFRALYEGRSGEDSTAKACIAKLFIVMDMAEEKGTLRKLRANGGIVKTTPVNILWGLAHLVTITRSYCTLRTSAASRTRRAKESYGISDSRHEVMILRAEIMMEQALAHIFRTELEEADKEILAHLRDTNLFKTYFPQVCMLHGQLAHQLGLAEVADRYYSTAKGSVAAGSEFGLVVEVNRLAAIGELEQVTEDPKRMHTVNVLADQCRSGDNMAFHAMGNFLSSIADPERVRKLTTAYKQAKRINFRMLYALIFAFTTGIHLYGDQERQLRQLETGRDMTKLLGGQERDDEVGQPILGYWYTFKLIKLYRLTQRLEEEAKMKESYAKHAARIKEMKAFGAKRFANLPARRRKERVPSSLGKEVATASTTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVT7</accession>
    <name>K1WVT7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVT7"/>
    <dbReference type="FunCoup" id="K1WVT7">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WVT7"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_2_2_1"/>
    <dbReference type="InParanoid" id="K1WVT7"/>
    <dbReference type="OMA" id="DGCDITQ"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF55">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013175402" evidence="3">
        <location>
            <begin position="16"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="491" mass="53369" checksum="CBBBFE7509B18160" modified="2012-11-28" version="1">MLSLILTTLLSTASAAPAGIVGSTYADVYPPGSTTVDRGLFPDRTVVGYPHVTRTGAQPYAIVTSPADLFPKVQQAFGPVVLPEARNSRGGKGKNSDNGNGKKKGKGKKDKAGHLKASGDLAFLNDWTYKLGSDILVPFGRQQLYELGVRSRIAYGHLLNDFTERGELPVFRTGSIDRMVETMEAFGQGFFGRDSQKQFSMSIAIEEKGINATVYPGGGTCPNSDRDVVASKLGMAEYVNRTFAGTAKRLQKDLEGYTITPGDVHTLMSLCSYETLALGYSAFCPLFTHDEFLDYQYAWDIMFFYGNGPGGQTTAAQGKGWVQEFLARLTHTPLESYDSSTNSTLDGNPETFPLNQSIYADASHDSYIMSTFTAMNLPIHGGALPLDKRVDGRVFTSSALVPFNTNFVAQVLSCEGMEGQQIRFIINDAVVPLHEKYDGCEEDEDGICSLHAVVEALQKRVAEIDYTASCRGDITNITDTAQLKDSNGLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V100</accession>
    <name>K1V100_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V100"/>
    <dbReference type="STRING" id="1220162.K1V100"/>
    <dbReference type="eggNOG" id="ENOG502TM5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474237_0_0_1"/>
    <dbReference type="InParanoid" id="K1V100"/>
    <dbReference type="OMA" id="EWPVIER"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="575" mass="64142" checksum="A3EE097123C763AE" modified="2012-11-28" version="1">MTRPIDRETAAVLEPFLQALRSDKTLTIPKATLLGALTHFLSLLDGDNLEAYVQDVLSSPSLWDAVTTHDIENAVRSAPASKVAILKPKIKDTFFKRNRVAKASQEWLGDLVKDLHKSGNTERTLPILVGILNGISDVKDIDWGKPRLELEDTLVITLAERLEKEKGDVDVLRLFSSVAEDIQPERLRVLDLRDALFRSLEPGSTTDAQDKLADAEDFSIGLSSAIEALAKGGSRSQEYAWSQVEAFTRRMFLSSELFDQEWSGLSKPVIGGPVEWPVIERLIAISERRVGTEQTVDLVTLIIRTLSKFTPVTEEDQEPVDNYEKTLYGAFDILAGEGGGRAVRTLFDHLEKKEHISDSYAAFVLTVGEQLVRMVDSRTIRDFLLPLADKYVVRPQHKSSFQSAFAFLLALVDAASSHLEFDPNQGGFVEAMVYFVAHALLRESKDGSVTTEQLRQAYPQLVKCASRRSPELVHQCITLLNKTDFTTPEYQKAVDAIRVGLIPAVPAPAMGEYLDKIANLILSTPKGSEERLELSSLAFKAVIQEMPDETKQQGIDWWLKHRRVFDGKDEPSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V229</accession>
    <name>K1V229_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V229"/>
    <dbReference type="HOGENOM" id="CLU_1807586_0_0_1"/>
    <dbReference type="InParanoid" id="K1V229"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851804" evidence="1">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="127" mass="14653" checksum="6379E7DF32F3CEFB" modified="2012-11-28" version="1">MLLLPLALSLVPAAATAKLWGWPDSFSVSADVFGDNISDPNWMRHFDHRLAVGGSYLHPEVWTWAQIQKENSAWVDFWRQGNSDTFNMYESNKDGTVHGQCQIVHFHEEPQHCLGRKVMVLLNCWQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V279</accession>
    <name>K1V279_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V279"/>
    <dbReference type="STRING" id="1220162.K1V279"/>
    <dbReference type="eggNOG" id="ENOG502QTJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_2_1_1"/>
    <dbReference type="InParanoid" id="K1V279"/>
    <dbReference type="OMA" id="GQCVLPW"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="542" mass="59049" checksum="3771EF101DC61EE5" modified="2012-11-28" version="1">MAATERASIAAETTPLLSSAEQTYDSSPAQSEDRDDELEDKAPPEGPTVTRAEEWAYYLYYNGDNGVGPNGYAPVLFQSLATSSAINPITGQPCTSTSSTDACVLPFLGRDRRVASIVLLADGASFFLMTVLFTTLGSAADYGNASSTILLGATLLCWCAQLGFLFVGEERWRTAMALYIGGMVTYGVTLVFYASVFPRLARNTPATKTARRKISVVEGCGGDGLEAEKEAVEAEALERARLSSHSTAHSNWGYLIVLLLSLTLLLPSSTKHLPRIEVYVLALTVGYWFLLALPWFTLQKPRPGPPLPKGANWLTIGWKQIAAAVAQRKHLPYTFVYLTGFFLLADGINTTGALIRVLQARQTHFSFLSITLLNLSQAFFSILSCYLYLYVQKRHQLSSKRMLLITNLISIAIPAWGLLGLRSSSSIGFRSDWEFWAYNIVFGVGQAPYYAYSQAVMADLTPPGGEGMWFGLFGLTNRASSLIGPNVCAAIIERTGKDWAPFAFLTPICLAATLVIGLGVDVEKGHRDALDFADRKRGSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3A9</accession>
    <name>K1V3A9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carnitine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3A9"/>
    <dbReference type="STRING" id="1220162.K1V3A9"/>
    <dbReference type="eggNOG" id="KOG3719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282449_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3A9"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="74"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1106" mass="121943" checksum="448731ECE9ADC1AA" modified="2012-11-28" version="1">MANANGLNSPTPEAIRAEARKNIDHLTINGRSTIEPNGSISTSPPLPPGALTPRTRRNSKVGISSLYRADLPKLPVPALRDSMSRYLRALEGLQDQEEHEQTKEIVKEFLESGEGDKWQARLEEYAQGVDSYIEEFWYESYLSHQDSVVLSLNPFFVLSSDVTPRNDPQLSRAASLILSSLAFIHDLRTGQLKADNIRGTPLDMDQYERLFASCRVPTDMGCRMETYDDSRHIVVLRRGQFYWFDVLDSKNRPMLSDREILTNLQGIVADADKIPVTDTAQSAVGILTTENRKIWSNLRNELRESNKRNAKSLAIVESALFVVCLDDAEPADLGELCGNFLCGGYRLEHGTQVGTCTNRWYDKLQIIVCSNGEAGVNFEHTGVDGHTVLRYAADVFTELVLLFAKSINPSTPSLFKAKMSPFAKNSKTPREPDDVETEADTKPKKLEWALTPDLKQGVRFAETRISDLICQNDSKALEFRGYGANFIKRHGFSPDAFVQMAFQAAYYNLYGRVESTYEPAMTKTFLHGRTEAIRTVQRESVHFVKTFSSETASPAEKIQALRDACKRHTVLTRECSQGMGQDRHLYAMHSLIQRDICAARERGEKPPKVPELFRDPGYGTLGASVLSTSNCGNPALRLFGFGPVTPEGYGIGYIIKDEAINVCMSSKHLQTRRLLKTLQAYLLGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKIGSRSGQDRVKTGLRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3P9</accession>
    <name>K1V3P9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3P9"/>
    <dbReference type="HOGENOM" id="CLU_1476156_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3P9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851595" evidence="4">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="183" mass="19914" checksum="034FE5540674E7A9" modified="2012-11-28" version="1">MLSLIIFLFVTATLGLAAPIARRSESTDAPHRSGRSLGDLSPGEIAGMVLGIVLGLLLVIMIVAQATNGSRKMWARYRAKREQRKADQAEIAASRAQRALEQNEDDDRTAAWLAGRARNFSSLPSSVIDLPGTPEPAYYQEPKSLDEQLFTGTALRSSFELPPPAYPQDETGKSETKKLSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4F2</accession>
    <name>K1V4F2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spp2/MOS2 G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4F2"/>
    <dbReference type="STRING" id="1220162.K1V4F2"/>
    <dbReference type="eggNOG" id="ENOG502RZY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033338_0_1_1"/>
    <dbReference type="InParanoid" id="K1V4F2"/>
    <dbReference type="OMA" id="MEVFDDG"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="5">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="443" mass="51112" checksum="E49294D3C81876DE" modified="2012-11-28" version="1">MAPVSLTVRPPKGRGAPSQRMFQDDSDDEGDFGRASSSSSRRGREERIDGFANGRQVGTKKEKPLVIAPQPNKDWRAAARAAPSYRPEVKREEEVVTHERVGDGPQRRGLRKLTPPPDTKPSASDLEAADAAASTSVSTPAPGDEQPVKEEKEMTLDERALAALIAGENDEKPDVDDSMVIGLNSNTWQAQNEADALQRDLGGLPDEATLEDYAAVPVEAFGAAILRGMGYDPKNDTEIHVPKSRPALLGLGAKALSSELPPASHKKKKRQDPATRGGRGFNAANLLVKRESETPTSSRGVSRDVSRDASPRRVEDREDRRRDASPRRIEDRRDRDRDGRRYETDEERARRKARERERDRDYDRRDRERDERRDRDRRDERDRRDRDRDDRRDRDRDDRRDRDRDRSDRDRRDRDRDDRRDRDRERERYRDDWRDRERERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V601</accession>
    <name>K1V601_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V601"/>
    <dbReference type="FunCoup" id="K1V601">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V601"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025145_0_2_1"/>
    <dbReference type="InParanoid" id="K1V601"/>
    <dbReference type="OMA" id="EVFGAMF"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="441" mass="47652" checksum="4A19FCDD158B52C1" modified="2012-11-28" version="1">MFAHPAPPPRNPHSRPSSAPSGSKPNRSGGSTPAAGGKRRGIGSDANPIDMAYYDVLGLPASCTTEEIKKSYRRLAIKLHPDKNRDDPDAEEKQIAVAYQILSDPETRKKYNEFGQKNGGGGAEEMVDPEEVFGKMFGGDAFADLIGDISIGKEMKDVFQQQAEDAPEDYMMGPKGQPVLTPEAQARRSAREKAAADAKAAERTARVNKLAEHLTRKLSVFAEAAKSAEDPDVAPSFREICRLEAADLAHESYGTELLQAIGGVYKQRATQYTASAAFAPLGWFHGAKNTFATVSDTVSTLRSALELKSVFERLQAAEQAGMPPDELRKLEEQATEQGLRTLWKGAKLEVESVVREVCDKVLADPATTSEKRQLRAAALGLMGDAFLSASKQEPGPSADDFVRIETPQSKAREKEKASRPGVPPRPGAPPPPVPEKPEGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6W5</accession>
    <name>K1V6W5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6W5"/>
    <dbReference type="HOGENOM" id="CLU_090088_1_0_1"/>
    <dbReference type="InParanoid" id="K1V6W5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="239" mass="26897" checksum="973D717748324BD0" modified="2012-11-28" version="1">MSEETAPHIKKSEKWILGDITLISADRSSGCNADLSEVFSEVIELGGIKTLEFYDPELESAGTLDRFLDLAFNSELSPTCVSEHPTTAEVEFTRELLALVRFLQKYECWSLFRQLRMCATEHVKNKQLSAHTAFVVGAVAEEVDLCAAALQHACTVDADWRLNRHSAMRYWICAADPGSVERSLWDLLPAAYAWAWSKAWAQGMGAVEHRHSRQHELSRVIPEFRKAVKETEVRDSAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7D0</accession>
    <name>K1V7D0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyisourate hydrolase</fullName>
            <ecNumber evidence="5">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000356">
        <property type="protein sequence ID" value="EKC99909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7D0"/>
    <dbReference type="STRING" id="1220162.K1V7D0"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396473_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7D0"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="568"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="695" mass="75764" checksum="258A8055005A69E9" modified="2012-11-28" version="1">MYPQHGRHVSYQGQPAFSLEKALMMRTHSTPQAQLLRMQAAQVVNTRPTKHSQHRSTLSQGGKPFKVEIIGPFKTQVHNLSSSEYSGSTESSPEQHVSPSASLLAAHRNAQIKPPSLSPKTPTRKGPVSTAHLLESPANDTDWVAYSAPIPELDEVNSDIGDHSFESFDSESIASRSSTPDTMIERTLDTASGSASSSTTECDDEQLVETKRLLVQSTVETPELTPAASPAPTLVPLPIPFSPESKKVVEIALQPATAPPPAFNCDACGSEHARMMLFQPCGDLACPSCFSSSLAAVSVTQSAAKCPCCLTEVSSFDAYNPKDHVPLRRVARPAKVQQELEPVYWSFENSHKTVVMRIDNVAWDIEPHLVESWLPKNTLPIGHPCPVHICINRKDGRTKDYLYFEAASQDAARRVLQKCQNTFMPGGRVTSGRKRPVTVSQVSHSELLREVSPTTKAELTSLLELCEAALSTPPPKLRVDSSGRGRLHASVGANGKVHYLKYRHAPFHSLMSLMCELRGDPDSPAYWDLFHIASGAIAALASAIRVRLHHPEDHTLMKHFKLLFQESDLEGKKLTPVLDTTRGCPAQGMDIALLKLEGSGVNAKTTQVGSGTTDAAGRCDTLTKGPSSKGVYKLVFGTGDYFKALKMDTFFPLVEISFNLADEDEAYHIPLLVSPFSYTSYKGQHGGAKKKEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7H8</accession>
    <name>K1V7H8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7H8"/>
    <dbReference type="STRING" id="1220162.K1V7H8"/>
    <dbReference type="HOGENOM" id="CLU_264638_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7H8"/>
    <dbReference type="OMA" id="NHARERA"/>
    <dbReference type="OrthoDB" id="2596619at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1263" mass="128437" checksum="24F30A7B859AEEE1" modified="2012-11-28" version="1">MAKFTDKIADKLGDHPVSHHLRGRKWGEMLTSLLFSLVVLALIGVWAAATAGYETASKMSPDWNMTDNDHWFAKFTPPRAPPLCQPAFINTGSEFYTTNGIFLWQMGKGFNVSAEKAFGNNDTTVNFNSTLQEYSDYTLSHCDVSGLQIDMDLRGAEVAVQIYATCIDPTWPALLRSDVKFSVNPATGIDNSLWYGDVIQPESKESNDIVSPIQDLANDMWKRQRAMYLNTTGNDYPLVRGFRVRNSNNCAFETKDKKSCFEKPLQWSNDTDGFYMYPNLTISQTNYEPIVWNVTTNNLVQAVIAAARYDFGANMTNNLFSNNTVKGQIIQTQDSPRLVNVTDANYPMNPLSGARAFLATPEFAPAGIARVRTSYLCMVMRMKKPADFVVSVLGLMFALFGVVFTALAFLFHKITGRTVGGGPALIGAPAPIDIVHEGEEEQALTDKDGNPNEPRGPNGNLPMRSNSAADTLAFGAGGKHNSFGNLSQLTGKSGGGGGGGGFGAAGFGAGARSSSGFDLSSMAGKAGGGGSMLSMAGGLAGGLISRPSGVDLSSMSGKAGGGGSGINLSSLGGAGGSGSGLNLAGMAGKAASGGGSGLSLSGLASRASGVDLQGMANNMGGLQPPNGTSGSGFNLATPPMSRLSSFASQYNPFKGNAAAAGLGAAAGLATGAGVAAASKHQSGNSGDTTSDGGALTAVNSEIGSTSQLLGQYNVSNPYLPSPGSSQIPLSSSYPNMPTIPDNNDHPPIAGYVPTSGDDYTPRQSEDPAAAAAGAAGVGAAAGAATGAAGAAAAGYAPLPSTAGIGANNVTGNYFNSSPETMAQAQMPQQANPAVPGMPAAPAAAVPALGTREAEAQQFGAGGFIQPNQNSFAGRPEVVGQPIATPAPAASGVQAPSPTSANFSNLVPGVAGGVLGGTAAAAALAAGARMSSSPVGSPVVSPPPQLPAVQSIDLNHSPESEQPPVVPNQPYVENAQGMAGLMGQQPMSQASGHNVTQGVTGNLAQDIQNAPQTLQNFQGIPRDMAQNVQAAIPQNLPANVPQDAPRDMGDMQNAAMAGLAGAGLGAGAAGVMGMVNHARERAQAAPRELAQNMPQSAQGVVSNVQQQLPAHLPNGADRAVPSPINPGTGAPVQRGLDSPEMPDPSATSPTSIPTPNVPTALPVPSGETAGASPMSQPSILGSDQTTPTGPTPGPTPTAMTPSATRDGPSVPGMTPIGLAPETATATSFDGRPISAFSTDSVYSQRTSPGRRTSMLPVPEGDNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8C8</accession>
    <name>K1V8C8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8C8"/>
    <dbReference type="HOGENOM" id="CLU_1086611_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8C8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851681" evidence="2">
        <location>
            <begin position="18"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="256" mass="26686" checksum="0C63FBA4432DCF07" modified="2012-11-28" version="1">MLLTSLLTSTLAALATAAPTLNVGAGVGVGASVNLGNDLKASLHAAVFTSVNIGTCYSPELEGHAKSVPKKEARAQFVLDLVAAVEAKYPGHNCIVYPKKHAGAKIKFEIDAGVKGKESIKECQVEALELQGKAELYGVVVFQGAGWLQIGGHGKGHDKGHGKGHSEHGNGNGYGHGKDKGGKGNNGGNGHGGKKDDDGEACNECQEPEPEPETEDCNECEQGEQGKEKEKDWGYGGKYTEQEGGKKIVFQDCGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8V0</accession>
    <name>K1V8V0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8V0"/>
    <dbReference type="eggNOG" id="ENOG502S7P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110778_0_2_1"/>
    <dbReference type="InParanoid" id="K1V8V0"/>
    <dbReference type="OMA" id="WLRTAIW"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="167" mass="18094" checksum="5F8B3841ED8B393B" modified="2012-11-28" version="1">MPGTLEHQLGLHVVENYSFYAVPAAFLSAFAPHLFAIMLVNNRRAPGGKGFNLSMPRKTREFVSECQLTPKDQDRFQRAEAANDNGFVSLPFFAAAIVAGNLAKLPNKTLNNVAALYIGSRIAFNMLYIFGTTNASGIARSVAWLAGMGGCLSLFVQAGKTFQKAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V984</accession>
    <name>K1V984_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferro-O2-oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V984"/>
    <dbReference type="FunCoup" id="K1V984">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V984"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="InParanoid" id="K1V984"/>
    <dbReference type="OMA" id="WHSHTEH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853631" evidence="9">
        <location>
            <begin position="19"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="155"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="387"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="636" mass="71240" checksum="A0FD4E2DF46FD17C" modified="2012-11-28" version="1">MVAKAILAASMAAVAAQAKVIEHWWNISYAQANPDGMFERRVIGINGTWPPPVLIADKGDKHIIHATNALGDDNIPTALHAHGMFFNNSAYWDGATGVTQCGIPNGQTLDYEIDLSRNQGTYWVHGHYNGQYVDGLRTVSIIRNPRADNLTWDDEYTLAVSDWYHRQHQDMLDNDFLHWTNPTGAEPVPESALMYVIDKDGNYVGGADKVTDGSVTNDNAKIPFEAGKTYRIRIVNMAALSMFMIKFQDHDMYVIETDGVEVEPYPIDVVTVSVAQRYSILVKAKEKPTQNYGIAVYQSEDMYDVVPDDLILNNTVTLEYFADQERGQEFVIEEYPLINDTEFRPVEKIASAKPDVEFTIHAYFDTFNDGTNRASFTQDGGFQNVTYRSPKVPSIFTAMSMGDDAFKPEVYGQQTGVITYKHMDMIQLTVHNWDAGFHPFHLHGHEFMVIEKSFNVSSDDAIENPPILEDQANPARRDTITIPPEGKVVLRWRADNPGVWFFHCHIDWHLSSGLAMVFVEAPDVMQKNLKIPQQMYEHCQIKDIPTTGNVVGLNSTSDFKGQATGPQPLVMGWTPKAKGVMAACVITVLIGLATIIWYGAGELNEEELEEEVRRAVEAKQNKVPLWKKALGGKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAI4</accession>
    <name>K1VAI4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha, alpha-trehalose-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAI4"/>
    <dbReference type="FunCoup" id="K1VAI4">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAI4"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_2_1"/>
    <dbReference type="InParanoid" id="K1VAI4"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="451" mass="51088" checksum="B6AFA850F057593C" modified="2012-11-28" version="1">MSDPAYQNNHHSSPRSNHSPQMFTYDSLPKAENGAPEPRLIIVSNRLPVTITKEANDVVWRPSLSAVWLQENNVIHMDRVARKRLQDREYVNRRLLEEYQCYPVYLSDDLADRHYNDVVSNFVQTGDVVWVQDYHLMLLPMLLRSMISGESAQGEMTRKEMGRVKAGVDDVEEFGMQHGVAQGLDEGVEMLEDVEEEGGEVTTTGGSHHTAMVRGLSAFQQQEVQARQRGKGGVRIGFFLHTPFPSSEIYRFHTYDYARHFLSSCTRILGLETQPNGIEFEGRYAQVGTFPIGIDPWQFVEGVKSPAVQSRLQKLERRFEDCKVIIGVDRLDYIKGIPQKLHALEVFLTQHPEWIGKVVLIQLAIPSRQDVEEYMNLRSVAYEYISTQSEKHGSMILSEFAGASQSLAGSLIINPWDVDSTASAIHTALTLSPQVREQNWTKLFSVGDLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB52</accession>
    <name>K1VB52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB52"/>
    <dbReference type="FunCoup" id="K1VB52">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VB52"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="K1VB52"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="61"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="882" mass="97305" checksum="EE9428AB0DC7BD84" modified="2012-11-28" version="1">MDLRCRSAVGDLCPPRPSDSVALSLPPLMFNSAHIALRPVAQGLRSGFTVDEIRELMDKPTNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGEMRFTDTRQDEIDRGITIKSTAISMYFPIDKEDVADIKQKTDGNEFLVNLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQSLGERVKPVLCINKVDRALLELQVSKEDLYQSFSRTVESVNVIISTYTDPVLGDVQVYPEQGTVAFGSGLHGWAFTLRNFATRYAKKFGVDKNKLMPKLWGDNYFNPKTKKWSKSAPDGVERAFNMFVLDPIFRIFDSIMNFKKDEIPTLLDKLEIKLSSDEKDLEGKQLLKVVMKKFLPAGDALLEMIVINLPSPVTAQKYRVETLYEGPMDDESAIGIRDCDPKGPLMVYISKMVPTSDKGRFYAFGRVFSGTVSSGPKVRIQGPNFVPGKKDDSVVKSIQRTVLMMGRTVESIEDCPAGNIVGLVGVDQFLLKSGTITTSETAHNMKVMKFSVSPVVQVAVECKNASDLPKLVEGLKRLSKSDPCVKTWMGETGEIIVAGAGELHLEICLQDLENDHAGVPLRKSDPVVGYRETVQAESSMTALSKSQNKHNRLWVKADPLDEELTKDIEEGRVAPRDDPKTRARYLADTYGWDVTDARKIWCFGPDTTGPNLFIDASKGVQYMNEIKDSVVAAFQWATKEGAVCEEPMRGIRFSILDCTLHTDAIHRGGGQIIPTARRVCYAAELLAKPGLQEPMFLVEIACPDSAQGGVYSVMNVRRGQVFSSEQRPGTPMYTMKAYLPVSESFGFNADLRAATGGQAFPQAVFSHWELMNGDATEKGGKVNELAMKIRTRKGLKPEVPPYDQYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBD6</accession>
    <name>K1VBD6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">A1Q2_04343</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBD6"/>
    <dbReference type="FunCoup" id="K1VBD6">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBD6"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="InParanoid" id="K1VBD6"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EKD01355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="198" mass="22356" checksum="05BAD8072CB905DD" modified="2012-11-28" version="1">MFILNWFWDVLAQLGLMNKNAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVRFTTYDLGGHMQARRLWREYFPEVDGIVFLVDAADVERFPESKAELDSPLSIEQLANVPFLILGNKIDAPGAVSEEELRHQLGLYQTTGKGKVPLRDIRPIEVFMCSVVMRQGYGEGFRWLSQYPATPTVAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBL0</accession>
    <name>K1VBL0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBL0"/>
    <dbReference type="STRING" id="1220162.K1VBL0"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="InParanoid" id="K1VBL0"/>
    <dbReference type="OMA" id="WVPETMQ"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="118"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="624" mass="69082" checksum="5F66ED74C94F3586" modified="2012-11-28" version="1">MSHTPSEKGTPPSELATDKASDRQIEDAVADLNFDNDKTAERCAAGVTSEDAYNPLRRLDKTALLAEADNFVDKFGLTEHRDVFRRGALVAQRPKEYADIPELSDADKADLAFEENHMWKNLSPRLIFCGIAKLIVSNGANLSFPAEFGIGRTVGEPGGERDEWLVGLVNSSVYISSALVGCWISDPLNEWLGRCGEIFVTGLILIATPIASGFTQSWQALMAVRFVMGIGVGAKAATVPMYCAELSPARLRGALTMGWQLWTAFGIFLGFCANAAVKDTGMIAWRLQLGSAMIPAVPLTLGVLFCPESPRWYMKKGQMVMAWQSMLKLRRSDLQAARDLFYAYSQYAEEQKVVQGRTYVSRLTELFTIPRCRRATLAGSVVMIAQQMCGINIMAFYSSTIFKEGGYTDTQSLYASIGFGALNFVFALPSLYFIDSYGRRSLLLATFPNMAWTLLVGGLCFLIEPYDPDSEIRTGIVACFVYLFTIAYSLGEGPVPFMYCAEIFPLAQREQGMAWCVAFNFFWGSVLSLTFPRLLREFTPLGAFLFYAGLNVVAFILIFFLVPETKRLTLEEIDAVFAIPTRKFAAHQLKKTLPYLFKRYICGDKSAVCPPIVHLAEPPNGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBN7</accession>
    <name>K1VBN7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBN7"/>
    <dbReference type="STRING" id="1220162.K1VBN7"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783441_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBN7"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="355" mass="39451" checksum="98D829A7C73C1B40" modified="2012-11-28" version="1">MFRTALQTVRPQARAFSASALRAAGSVNYNDVKPLTKQPTDDVTIIDVRDPKEVENGSIPSAVNVPLNRLADVLAETYPDGAFQKEFAFPRPSKNQKMIFYDRDGKNLQKAADIAEKAGYKNVKNYEGAWQDWQDKEAKSKNSAADFPPAFDVASMLSREIHARLPPRPDRLKPPSPKCPLFGAAHENPAHLAPPHHLDPEQTTMGNKAWILRDINKRIAATQVEAQRNAYLAVARNTTLPAQTRHKAQLALNQYNDGKGRMVSIRNRCMWTGRGGGECYFAAVDAAVLCGQWEVETGPLAGLWRAAEEAWRLAATSERREADKQGVLNNFAQCRFQFRKNALAGNIPGMQKGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC02</accession>
    <name>K1VC02_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC02"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="K1VC02"/>
    <dbReference type="OMA" id="ATITICF"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="512" mass="54805" checksum="5C849E4E02BE236F" modified="2012-11-28" version="1">MTDTRSKPWRDPSLPDGDCIHATDAQRQALVEAEFGAYPTASFNDVPLARNVSRVSAQSGTQHVLPSGVEGYDEKGRGGAGGQTLEYHAEKGETEAQREHDENQVLEEASRMEYVEPGWKGWLNCAGSFLVNMLCYGMTQSWGVFQQEYAHGKLSSTSGMAVSWIGSIQFALCPMLGCVSGPLLDCGYLKQLMMVGGLLYTFCLMMASLSKEYWQVLLSHGIGVGIGMGLIFSPSVATLSHHFARSRYRTLAFGLQASGSAIAGIFLPIMLNYLIPAVGVDWSLRILGFLVLAFSAFAFFALSTTVAPRKKVAVLSPEVFRNKAYTVYVAGACLASMAIYAPQTFGVTYATSKGVPVSLANYAPAIANGVSLFGRIIPLFFAQRIGPINVLAAFGSASGIMMYFWTLTNSVGAILAYDAIYGIASGGYGASMNPGAASFAPHTNQAGLYLGMCFFVSGFFWLAGTPITAQLKDTNDTYLEASMFCATVVLVGSIGIGVSRVMRSKQVGTPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC07</accession>
    <name>K1VC07_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC07"/>
    <dbReference type="FunCoup" id="K1VC07">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VC07"/>
    <dbReference type="eggNOG" id="ENOG502QW3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012543_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC07"/>
    <dbReference type="OMA" id="VVIAYVC"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854050" description="Cytoplasmic protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="168"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="410"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="76397" checksum="10C2958F90F21D37" modified="2012-11-28" version="1">MRAALLLPCVFALAAASGPIARHGGHDDDMMDGDMMGGEMMASASEPSDPKWTATSAAAGGEAAPRPFGTMTESVQPSPTPGSDDHGDSHDTPAHHDDHHDSHEAHDAPPDPHGHHSHAPVKEFLNDTEIHRWHKFPPTYLDADFRLTQDSVIFGEELPENWPGDTPSHPGLMVLHVAAMCFAYFGALPVALSLRAAGHPSHYLVNTGFIALAVFGWIMGIAYKAAMPDFYPGAKHGGIGNILVLLSIGLAVLDSMGLIARAIAFYRSGSRDWKNFFFDALQGAKEDRFGDASRYEMVGFNERGSNAVFELGDDGDDEDGLESRHSTGSEGTLQDTPSASSAGSAHHFEMGDRPKGKSVSRRQGAFDAHHEDDQHEHEEPEVPLVAEKYTAMRMGEIALTWVRRTQVVIAYVCICTGIPTYLGMCRAGFINTCAAHIIKGSIFFGYGVLTFARYLGAYADMGWAWNRKPAGSRAVSAEMVECFVIFLYGITNTWMERFGAHKGDPYTVKQVQHISIAVMFWFAGLAGMLLESPRVRRVLGAAIHAANPRARTPPSYAFSFNPLPALVIAVTGLAMAAHHQDYKFQVAIHSLWGILLAGGSACRFLTYFFLWLRPPTESTLPSRPPTEVLTSFGWAAGGIVFMLSDEEVAFAAMRAGFDDMMAFLNVTVALTCLIFCWIVVVLACKGYALLRLSKGVSLDIESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCM3</accession>
    <name>K1VCM3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCM3"/>
    <dbReference type="HOGENOM" id="CLU_513074_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCM3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="531" mass="57370" checksum="D98441105882D340" modified="2012-11-28" version="1">MCFLHRLVRRQTTQPTEQTSLLTGPSPGVTSIRSSATTSEPLGTVHTPTSRSPRNAGRRCNTYAIDSSGQAYEMPPMYERSPSYTPTPTSGEMTLRASPLSPVPVSTPLSPEDAVDVQPPAYPKPTLRHRLTVALEGDLYSAPNRAPSHRQSGQSRRCLSTPLIHAGTKTKSRKKRHSLRADLLGHSSPSTASTWSLSSASSGLDSDSDSEAEAEGELSSPSAKRWWAASRAPVRLRSVLTAVLYPFGASRVLGAHTGRRATFVSEMSSSFSSASLLPGLPSPSPPAGKLATSRLQRSALGLHRPHKLEQQPAHDPRQTLGRVDIAVHDHGQGRGAEHRISKGDDGDPRPLPGACPRTLQRLGEDVHGELCAALALLGKETEGIDEAHDPERLLARDEGAEQTGQAGSGEFTAGFQRVRAQTEQGLVDDDEEAEERAGTRDAQRDSREHPERVFRERVPAQHDGRDQVQRAVHWQHEAEGAEEALDERVPATLGPGQLPQLMHIVPRHALAAVRLLATAKVGTPLALWIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCQ7</accession>
    <name>K1VCQ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endothelin-converting enzyme 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCQ7"/>
    <dbReference type="STRING" id="1220162.K1VCQ7"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_2_0_1"/>
    <dbReference type="InParanoid" id="K1VCQ7"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="111"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="269"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="676"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="884" mass="98716" checksum="FD7BDE91B25560CA" modified="2012-11-28" version="1">MADPPENAPLLAGEDHDHGPVQTRRSRKIFGYDTGMSTRELILGSLAILFLIVASTFIGLYIATKAHLRKDHKHHDDHPGDHHDDNSVCSTPDCVLAAASLIQGMNTSADPCDDFYEFANGGWLQSHPIPADRALVGTFTTVSDNNKKILTKIIDSIPASSESHALDAEHDNLRKLKDTYLSCMNTDLLNELGDKPIQPLVKHVLNTFGEFNVPLEGDDTSFAPPSYLGKWNEAYEIPQSLRAVANQNSEILASIRDGHHHGLEKPSSRPAFDALGGGDSGNRKRNEKITDVLAFLHARDVDVLFNFAIEGDAGGENSQIQSLWFYQSFGGLPAKEYYEEPEIMDLYTQVVEDMLTAVASGGKKGQRDLLTSIAEGAMEAVEEGAETWPWPWPGSDDEPAPEEPLESRMKKLANKVVEFERQIVKAGADLEYLFNPHYSYNPIPASAVDQYLSFFNLGQYLAAMAPRTRPQKITVTYPPYLKSIDKLVSEVSDPVLSAYFVTKLALQWYGALGPKTPLFAAGHRLSNFLKGIKPDQMQDRQDVCLSSIDLVGFIAGREYVKAAFSKEAKEDATGIIQNIVNEFHDELPHIKWMDEKSAKAAQKKASALIPKVGYPLNPNTEDPESLKSWYRAVDIKPDTYFDNNIAATLASNARTWGGLGRERNRDSWEMYPQTVNAYYSPPDGEIVFPAGILQPPFYSYNWPKSLNYGSFGAVAAHELTHAFDNSGAQYDDKGRLRDWWTNRTVENFEKRAQCIAKQYSQYYVLDDKGNKVHVNGNLTNGEDIGDSGLKQAYNAWRKVEEDKPSPAHLPGLAYNEEQLFFIAFARSWAQVTRPATAVARIRTDPHSPPYWRATGTLRNLDAFHKAFQCKKGTRMNPEKQCKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDB1</accession>
    <name>K1VDB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDB1"/>
    <dbReference type="HOGENOM" id="CLU_2238500_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDB1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="105" mass="11292" checksum="9C91D39D55319903" modified="2012-11-28" version="1">MLSLTRPLDVPTPTTTPESCSLWVLRVPPPTSPGFTLHPQYLDVMAQKHPTKSRDDIQNVLSLYPARVAAAYELARQTCMAKGADALGGVGEKIIASAKEHGVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDG7</accession>
    <name>K1VDG7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDG7"/>
    <dbReference type="HOGENOM" id="CLU_816807_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDG7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37874" checksum="A7624AD11E86D944" modified="2012-11-28" version="1">MSDLIAPPRRRNVLSRFLHTLHLLPRPEAPPPPLCVCGHPPHGIEPHMKPFLPRSPPEPEFEDWPEDTSEVEYPVPAYSPPRVSPMYRHVRYEVVGPTPAPWTEAAESWVACERAHDHFLIKVRFGMHKRVYCLPWRGERTTFGHIKAKFAHDIYKHLGLGPVFLELWVRGHRVSGHEVPAAHGVKNRDVIECRPVPQLLRKPLPLYTDVPPLPLVSYETLYPALDAGLNGANKQQASQGSDTRPGRESGMATSNRSCEFGERPKLNSYPAFHGVNKSRSRAGGDCMPGATSLNHSRSSSATSTYSKRASSATQSSQREGKPYPGTEHWSTGAEPVEACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDL5</accession>
    <name>K1VDL5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDL5"/>
    <dbReference type="STRING" id="1220162.K1VDL5"/>
    <dbReference type="eggNOG" id="ENOG502S1MK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051552_1_0_1"/>
    <dbReference type="InParanoid" id="K1VDL5"/>
    <dbReference type="OMA" id="AREGMWA"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="265" mass="29061" checksum="282851CA59C49754" modified="2012-11-28" version="1">MSLDAFEARLQFIKLLKTLNASQASIVKVVSFAIKYGPRCGEDLWTCVVDEVDKASLNARINILYFLDGLIEASSQVEGVPYIGLIENSLPALVEKVVPNTSKGYINLKSTRDILRSWATQRLLNPTIVQEVLDSLDAQTFTGGSGTPAQGGDDETLAAVAAGPGGGSEGTPGSNGSKRKRESMKRSDVLLRIEEDRERQKRLREKRWILPIPAPGSEVNPADVEFDLMWDALEVAPGLDDDDRERMRHDLAAAGLARDQRAHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDX2</accession>
    <name>K1VDX2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDX2"/>
    <dbReference type="eggNOG" id="ENOG502RSBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078271_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDX2"/>
    <dbReference type="OMA" id="VKIEQWL"/>
    <dbReference type="OrthoDB" id="3365310at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="268" mass="29355" checksum="AC8BB18190CC0F5C" modified="2012-11-28" version="1">MPPWSPVTFRQGATMLSGIFAARFFSSSGSGSSSVTSCSKRLVRPASPYAARESPTPLIFLQTPGVDWKEAARRPRGQENWQDWSAMFAEKGYTSVEIDVDVRTERSGTPEFGSREDAATSEQQQQDKSDIELAAAELNQQIRLLAVPFAPVIIASGPSCLVAQTYVESYPASGLVMVDPPPDNDPRPNGVKDGGFEWPKFTYEPRFPILIVARKGDGQRIEDETRVGSAAKDGVGRGGKGVEVIEEVDGYGDKTRNEVERWLDRCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VED2</accession>
    <name>K1VED2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_06405</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VED2"/>
    <dbReference type="STRING" id="1220162.K1VED2"/>
    <dbReference type="eggNOG" id="KOG1440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023471_3_0_1"/>
    <dbReference type="InParanoid" id="K1VED2"/>
    <dbReference type="OMA" id="CTIPLSF"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC99205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="211" mass="23265" checksum="0E603AB097D6C428" modified="2012-11-28" version="1">MAYVCGKLFGRTPLIKLSPKKTVEGFVGAFILTLLFSLAWGSFFMRFPYMICPAKDLGVNALSNVSCKLNPVFVWRNFEFTGALRALLTTILGREPPAIPYVPYQLHLLVMATFASLIAPFGGFFASGFKRAFNIKDFGHSIPGHGGMTDRMDCQFLMGIFAYVYYSSLIRIQNVTVGSIIQTVVTSLTLDEQVTLMGDLKRYLAGQGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGM7</accession>
    <name>K1VGM7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGM7"/>
    <dbReference type="FunCoup" id="K1VGM7">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGM7"/>
    <dbReference type="eggNOG" id="KOG2598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_2_1_1"/>
    <dbReference type="InParanoid" id="K1VGM7"/>
    <dbReference type="OMA" id="FWEMFPY"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="3">
        <location>
            <begin position="238"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="2">
        <location>
            <begin position="374"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="585" mass="63440" checksum="187D228B7216A0C7" modified="2012-11-28" version="1">MASTASVTENVKAMFEQVPPPHVLTVAGTGGGAGIQADLKTITALGCYGSSVLTAVTAQNTLGVQGVHAIPPSFVISQLQSVFDDLPPASVKFGMLAGADTILELSRFFSALKSLTPSAPYLILDPVMVSTSGHDLLKQEATKTLRDELIPLVDLLTPNIPEAVVLAERTAEIEGLGDMIALARELAQKGPAVLLKGGHLDLSARDVRRTKLEQDTKVYHLRPDSLVCRDYATSLQLPDAEEVVVDVLADKGGVRLFIGPKVNSSSTHGTGCTLSAALAANYAKQREREDLEAEAEQQKTDGDDEGKKRKHHISDDTIAASIAYVQGAIAAAFPMGAGHGPLNHGHLSMQRPLPPPTTANPTPFTDHLIRSCGSLWDEYVQHPFVVQLGQGTLPLDAFKHYIVQDWHYLRHYARVHGLGAFKASDFDTIQAFAEIALHIAKESEMHVEYCKQFGISRPQLEAAPESTACSAYARYMLDVSSQGNVLDTYVAVLSCLIGYGEVGLWLANRVETGEATLEGNPYKRWMEDYAGADFIGAVRRGIANLERRVAQDPPSEARLAQLAEIFRECVKLERDFWQSGLEMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGU2</accession>
    <name>K1VGU2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGU2"/>
    <dbReference type="HOGENOM" id="CLU_1817160_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGU2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="142" mass="15422" checksum="E6B953CE667C5B66" modified="2012-11-28" version="1">MGSVESHESRLDSDTAHWPLSGPPSIPRRSWQIELSEDIFNHPIAIAPEADSPPPPRTKPSLLICASALCSADTVMGAGLHMFTLSSPGCRACRDCYRLTPHPHHGFDQSDPQAQHGEGDPRRHHSCRPLPASQRAGLPVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH83</accession>
    <name>K1VH83_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH83"/>
    <dbReference type="STRING" id="1220162.K1VH83"/>
    <dbReference type="eggNOG" id="KOG3183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061621_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH83"/>
    <dbReference type="OMA" id="IVEMRCE"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZFAND2A/B-like C2H2 zinc finger" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="233" mass="24843" checksum="382462969C44E9E3" modified="2012-11-28" version="1">MCNEVVPYPPGGRLDPNEAVERHIAAGCESMEGGAARKKAVLRQKKAQGKVCWRRGCSKSLIVEMRCENCRHNFCPSHRHQKEHDCKPDPVPATRPGAKTAGSRLLGLGGKMPSVSVPSVSARSSVASKPTPPKQPAAIPAGTQASAGEQLDARAAAAAAAMKRAGGNVKVPFVKTKAEKRVADQEKSREKALAARKEKGLLTKADEVRYAEMVAKKEASRRKGEDKDGCTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHU1</accession>
    <name>K1VHU1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHU1"/>
    <dbReference type="STRING" id="1220162.K1VHU1"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263936_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHU1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="397"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="525"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1228"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1248" mass="137939" checksum="1D7F725650EDA483" modified="2012-11-28" version="1">MGLSEDLIQRLRNGGDRPASRQGPAPRSFADLRSDPSKFSSPLLGNSGLTTPLRPRVVHDISRPTTQRRGLDDPFLPSTHLTPPLSSSPPSRRQINFYDPDHDRNANGLITFADFSSQPLQIPATPVHQLSSNIGRFEHHLHESPNALDGYGTRHSLFSESASQSQIPSPPIEDSTAADYLFFEPAQRVPANEGDTPQLQQVPESEDEYAVDDQWFESAMAEVDLDRIQSKSSQKQHSLSAPMQSAEPAPERTITRSPYFPASSQPPQTQQLGQLRSSSRLSNTSSSVTFPKRPGSGLQMRFNAATPPVLTPTPHKAFAEGQQSQTTQLPKPRVGSGLVPISELEARLFSFEHFNKMQSAVFEAAYRSDENLVVSGSSPSGLEFTGDTDFSALYNRVRTPEKWDSVTRRTSMNRMLNRLQLVMIDEVHTLHEAPRGATLEVVVSRTKSRGDAVRFVAVSATAPNIDDIARWIGNSIAPHTSDQDSNNPVAHMPKARVFKMRPVPLKKITIGYDCGNGNKFAFDSRLDKELFPILTRYGEQRPILVFCATRKGCQATATKMAKQFEDALNSGQALPWDHRKKYVSTSARADVSERLNLKDESIQALTKHGVAVHHAGLDHMDRREIEQAFKNSKLHLLVATSTLAVGVNLPAHLVVIKGTSMWNGQGFREYSDIDLQYDTSGTVVVMCERAQVSRYQQMLDSRMVLESCLHENLTEHINSEIGLGTITSLREAQDWLKRTRNTTSTKLPETGLGLGMKHWSPLDNLESQDLVSNEEDEDYAGASQRRVLRLTPMGKIMAHNFVSYDTVSDWRSLTDSSQMCNIMTMEPDADLRSLLEILAGSEDDDIRFRLGESVKTYADKVFLHLQIIFGNVSLDKFATKAENGSPMQTQMAIYNSAPRIAKAILLVATEKEYGGASRAALELVRTVNGMAWEDSATIFRQIDQIGPKSISVLDANGITNASRLEMWLNRQTPFGFEVLSQAKQLPRFYLTIGLDNGEERKNPDPAIRKEKDGWPVVRLRVTVVCRGVYNTAAAKKTTKTSASKRGRKSKKSTEDLADDDNEMIVNVKLCSPTESIIAIAGNRAKNPSDPEAELSQPSPSSSQEDCHSPAAKATARKGRWKHCPPATESEEEVDELASSSSSGEELIDLTARKRRKTKSKSPNGSQPPKRSKNALSAAARKAILENVESVKKPVRLCPTWATRNSDGGAKGVSLANDPEEDVFYTQARAAPAKRPRLRSGSEFASHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI13</accession>
    <name>K1VI13_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI13"/>
    <dbReference type="STRING" id="1220162.K1VI13"/>
    <dbReference type="HOGENOM" id="CLU_1176137_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI13"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="24810" checksum="8F7DF87E25ECDE81" modified="2012-11-28" version="1">MSSASVPPHAGLVLSRTLIEPRGGGAWPLSAPVSGIPRRDKFSQASPVKTVAKSSLAQPTIVGQLVSSKGGSTNVGAIVGGVVGGVLGLALIIGVVVGIWLCTRRRQRVKEEKEDFVIDDTAAAMEPMEAMETAVHPITPYRGESKSSYGTGPGTPTLVPLLPSDAQPPTAYALSPHSLQTQQVHAPFAMPGPYSPASPRIPPSEYASEYAVDAGPVREQHPPRYDPRWSQRPGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI38</accession>
    <name>K1VI38_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI38"/>
    <dbReference type="STRING" id="1220162.K1VI38"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1448695_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI38"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="187" mass="20744" checksum="6EEE48BAC7C5773D" modified="2012-11-28" version="1">MFAVFAKRRSGVSPTRVVQSVGSAGMARSQAMSHKGDSDLSFDSLSTNTTPYQKRRRTQQEGTWTRSLRPLLELLARRPQGESTWRCKAGDKAIKRNTVKNMVEAAAVRDLSDASVYSEYVLPKLYVRLAYCISCAIHAKVVRVRSDKPGAINSRKNRAPPPRAIFRDGKRVNPAVAAAIQARQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI70</accession>
    <name>K1VI70_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI70"/>
    <dbReference type="HOGENOM" id="CLU_634897_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI70"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="331"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="432" mass="48985" checksum="75EE08B00E5AE858" modified="2012-11-28" version="1">MPATMRKHSLDIADTPSKRRRTDRKEDFGIMFEAKPSTTVSRLLELWAQHLERRDDDVAVDPTRLQLTDKWGPLNNDSTVQLLSDQFADAPGSTIAFTVSRIPSRPAQTLPPSRVITSSLSTDQKVSKLYEAVQKRYSLGEMEHGISDQGTSTINGTKVTGHDTYAKVTHTPSPPADVTIIYCSHFINHLDQHEHRRHQALSAEPMGRKFGYRDGCLQVELKGSHDAMLTFDAKPHTTVGALREFWAQHLEWRDSNIAIDVSRLQICLFNGEPLDPSEFVCYLPQLKKQGFTGDRTQRTVRLTVSRLPLRRPEDHGAQTFVPEITESSSRFTLYMKTLGGGTHTLRVSRSMTVLHLKQQVERLQGVSADSQRYSRRLLVQWLTGKAHLCRQADGRYAIAELLLPREFRPFYDAYGPEGSRLLTRRRKPSDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIP8</accession>
    <name>K1VIP8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIP8"/>
    <dbReference type="STRING" id="1220162.K1VIP8"/>
    <dbReference type="eggNOG" id="ENOG502S879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_2_1"/>
    <dbReference type="InParanoid" id="K1VIP8"/>
    <dbReference type="OMA" id="IKGWQKA"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="136" mass="14731" checksum="44FBEB2DE8E41700" modified="2012-11-28" version="1">MSAPWHANFPAGKSNPPEISAAELAALSGPGKEYIVVDVRRTDIDEPDAKTMHPAAINLPAQTFYPTVPNSAPLLKNIPKVVFHCNSCKPGGRGPRCAAWYQDYLDENGIKSSQALVLKGGYKAWAAEFPDRVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIR0</accession>
    <name>K1VIR0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIR0"/>
    <dbReference type="HOGENOM" id="CLU_453558_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIR0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="602" mass="62519" checksum="6D581A9311FA09AD" modified="2012-11-28" version="1">MMEAPSISKSASPHSSQEVVGNESRPRSDPRRSVTPRDRGRGRGSGPARSANGRFMRATPVETESMVDLGSVSVILGPSSPAGSVAVSAETTNSAGPPQQPGSGTSTVVTAAGRSLPVCQTPAATPKDEPLSFPPSIPSTPKQNGTGNHDFRVTPKVADASRLSLTEHSTATPTHDLAGPSFVAPGASPYEAVTTEVASGSKTTTPLPDPKGKQKRQLGSLSTPSSPGNQDTPSRPQRKKAVRRQETLGPINSALEAPAGPSTAPVQPRQFFGSATPAAAFGSGENVAGAFQKSSTFPYPALPASTPVIAPPAAGPSSWQLEPAKFADAQNPLLALTPPAHGQRVQDSGLTLDQKQTLRYMIWGQPLGLPPPSNHAGIGGVNAPFTAPAMVGAGTFAQQQASPPVLGHHAARTGVIAQFSATTSPTSSYGPATTTTYQDAMPQTAFPILQGQALPQWQHPPSYGTHYLPSYDEMVNNPAMLSNPNLAPWTTFAAHHANRGQNQDSYPNALGLSLSGNGMVPASSSISNPQPAFQHYSAQPNQNDHNLNGFNILDDPDVKAVIDYVDNLAAGNLDSFNPPPGTDDHTQHAEGTQPNSTEVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ15</accession>
    <name>K1VJ15_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ15"/>
    <dbReference type="FunCoup" id="K1VJ15">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ15"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ15"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="394" mass="42692" checksum="1F4248D0B1D0D9D3" modified="2012-11-28" version="1">MVARPFHSTSFTSAPVVVEVPQMAESITEGTLKQFNKEVGDFVKADEEIATIETDKIDVSVNAPQSGKILKFLANEDDTVTVGQALVELEPGEAPEGAEESAAPAKEEKKEEAAPAKEEKKEEKPAPAAKKEEKPAAPAPKKESAPKKEAPKEETTGAPNRKETRVKMSRMRQTIATRLKASQNAAASLTTFNEIDMSSLMDFRKLYKDGVMKADGVKLGFMSAFSKAACLALKEIPAANASIEDDTIIYRDYVDLSIAVATPKGLVTPVVRNAEQYGLVGMEKAIHDLGVKARDGKLTIEDMTGGTFTISNGGVFGSLFGTPIINLPQAAVLGMHSIKEKPVVENGQIVIRPIMVVALTYDHRLLDGREAVTFLVRIKEYIEDPRRMLLPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ88</accession>
    <name>K1VJ88_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ88"/>
    <dbReference type="eggNOG" id="ENOG502RC08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265929_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ88"/>
    <dbReference type="OMA" id="WERDWIR"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1502" mass="165766" checksum="2C939A36D2426B26" modified="2012-11-28" version="1">MHLRRTSKPSAQCPVPSAQPIEWERDWIREETGYEPETSDQRKRTQHQSDIRQELLLVTVTQCRPSRSRPPPNERSATCPHGAKDATACVCCSSPTKAMACSAPAQISSGRVIAQHRASRRIDSDDHTSAQCPVPSAQPIEWERDWIREETGYEPETSDQRKRTQHQSDIRQELLLVTVTQCRPSRSRPPPNPPAASQPAQPATKPRSLCTVTHTTSPTPLNTPHLPSPYPLPPIPPPSPPSPLHIDSLRPARTVLCIRRHLSSSNPHDTRRPRDKASLPARPCNPISQSAVAPFNRPTVAPSPVTSYDPRGPQEPYGHKIPPALRTARSTWLWVATHSMSSPSMTDEEFEREVRTLKDLRRRSVSSAGPGELPVDPDLPPRDQGEVGNAAPLGPQPFSSNDDVTLTVPDAGGDANGLFWVPAHLHPELAPGEFHAFLKSHTHANPTAMAAGESGEASLARSPSWLARSRTLSSGVKRNKSMLSRQYTPRHGDKVEEEVPVVTRRGSNPFGGEQGPTLQDLQKLDEMVGEVEDDPEQMRQILRRGLSMRLQPGLPEETVQSGQPGYGESSTGTSSSPRSSSIVRRSARTRIRKGSSIDGSKRYSVRKNRPSTAGSDSVFSDEADGRVSEERRSDETTQESGSSETPEVFHEARDEYRYQPKQQQQAYHSPPQPQHPPPPPPREEDEDQLRRPHQQPPTVSVSGIDFSQASDDEAMIFDAYTHDPHDRTSSSTYGSMSSAYDEQPSRSPSPEPPRVETTPRHTPILTPIVAPKASDAQWYEDDERTPTQESSMNAAMNAMRINVPPSRSSDNIYQQSASEKLQQQQQHQQQYQQAAPPTGRVPSPPRPAVPEKHDLPSGAAPPRSQTAPPGMSMQQRTGAIPSPIAPIAHVERPPLTRTESNSSAVSVGSTSTPPSVKKEKKGLFGKKSKHHDKPEKPKKEKDRFLGSLFGSKKKHEEATSVSNFSTAGPAAAAALLGTSKSAKAFHHQGSGTSSPTSPGFSNFARYPIHVERAVYRLSHIKLANARRPLIEQVLISNLMFWYLGVIGRTTPAEEKKPGTTNGLDRTRDQNANQPQLKGTPNKPADSGSAGVKQPDPPQQLQQHRRAGLSKPERSRTNNAEAAYRAPQYGMQSQMEEMHRSPAKQPVMQQQQQQPQQHHHQPTQHLSHHPQPQQQQQQQQQQQQQARPQPPPQQQQQHLPHHHQQQQQQQQQLHQQQQYHQPQAASPQAQPQPRTSSMPGRSRSPPTSQPQQRPEYPPGVAPPRVPQGGQYSHSPNRSQSSQHVQHMGQPGRAPVQPDGRQRVPSGGGGSQPPQQHPGARNSTIGPRPGQGYPQPNGRASDNPNRPIYPNQHAGTKPGQIFQYPGMVAAQQQYQQQQRPPGAGQAYPQQGGGPMYHQQQRPMQHQGPPQGWENQRLPGHQPQPGRSAASPPPMAQTPPRGSSSNRQPADPYGRPYREGQTSPTHQTFYSAQRPPTMQQGQPYPYANGQPRPQAVGSGQYPHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJC3</accession>
    <name>K1VJC3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01511</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJC3"/>
    <dbReference type="FunCoup" id="K1VJC3">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJC3"/>
    <dbReference type="eggNOG" id="KOG1458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_1_0_1"/>
    <dbReference type="InParanoid" id="K1VJC3"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000002">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="68"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="230"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD04165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="368" mass="40108" checksum="F9912D36439A0FE9" modified="2012-11-28" version="1">MTDSPDFEAPPTDLITLTRHILNRQHEIGEKASGDLTLLLVGIQSRVGWRVQASVGAVTAADVADNQVTSKYIASNVRKARLINLVGLAGASNVQGEDQKKLDVLSNDIMVNALSASGKVSVMVSEEIDDPIIVKGSKGTYAVVFDPLDGSSNIDAGVNVGTIFGVYKIEEGQEGTVADVLQPGNKMVAAGYTMYGSSCNLVLSTGQGVDGFTLDESLGEFILTHPNIRIPDRGKIYSFNEGNSMFFYPPTLEYLQSIKYPENKKPYSARYIGSMVADVHRTLLYGGIFGYPDDKKSKDGKLRMLYEAFPMAFLTEQAGGVATTGSQRILDVQPKNIHGRCPVFLGSKEDVNDLKKFYDKWQSPDKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJP7</accession>
    <name>K1VJP7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">A1Q2_01396</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VJP7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJP7"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_38_3_1"/>
    <dbReference type="InParanoid" id="K1VJP7"/>
    <dbReference type="OMA" id="CENRESK"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18980">
        <property type="entry name" value="CD_NC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000003">
        <property type="entry name" value="Transposon Tf2-6 polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="21">
        <location>
            <begin position="742"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="1324"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="20">
        <location>
            <begin position="1632"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="512"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="610"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1169"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1175"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EKD04365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1687" mass="194383" checksum="7F23BE62C91CF22D" modified="2012-11-28" version="1">MASATRMQALEAQLQELIDKQTTMQQENTQLRSQVDDIRSRRENTETSSTLSSSSGKHEPKVSSPEYFSGQRNKVTTFITQVRMVIGLQPSRFPTENSKVLYAGSYLRDTAFLWFQPYVASEKQPDWLNDFNLFCKELRSMFGDPDEVATAERQLYNLRQRGSASAYVADFTRYAALVNWNDEALCAQFYRGLKDAIKDELARTDKPKDLKTYKDIAVRIDTRLFERHLERDRSKTFTTTTTTFNNNNRSSYRQSSPSITTTKATITNLRPRMSSPERDHLSAVVSTIRGRITREEYDRRRKHNLCLYCGHVTTTNLESIPTTTTPNREKPKPPTHTQVHGIRENAIRKHITIPFKLYHRDRQSVFAPEHLHALVDSGATNNFIDIRFAHELKLKLHPVPHRDLILLDGAGRKTTIESEVIVNLNFENFGRQWVHCAVTSLHTFPIVLGLPWLQEHDPFISWTLKSIMPSLWAKSKHPVLDKDTALELIGRRRCDPPADHGPVFKKKKVTFDEPVSKTEKATSSRTAAGAIRSPTPDLGSRLEQGLPSSRAAASSKNGRAAAITGTTSAEESNRRAKRNHRKNSKINLRSDTGFEFSKFAPFMPPLDYTRHINHDTNDNTDSDSDTEFDMDTDTDSDRTARAMTPTEDRTSSLSDFALGALLAASYLASGVETEADDSTFVPPEYHDYLDVFSKAEADKLPPHRPFDHHITLQDGKTPPFGPIYSLSEKELGVLREYLDENLDKGFVVPSESPAAAPILFVKKKDGSLRLCVDYRGLNKITVKNRYPLPLIPELLDRLRKAKVFTKIDLRGAYNLLRIAEGDEWKTAFRTRYGLFEYKVMPFGLTNAPASFQHLMNHNFRDMLDDFVIVYLDDILVFSNSIEEHTEHVKLVLQRLREVGLYAKASKCEFHTNSVEFLGFVISDKGISMDMKKVQTILDWPKPCNLHDVRSFLGFCNFYRRFIKGYSVVANPLIRLTRNDVPFTWTDKEQQAFDALKSCFTTADLLHHYDPDQHLVLETDASDYAIAGVLSQEVDKELQPIAFFSRKLSPAELNYEIHDKEMLAIVACFKEWRHYFEGAAHNITVYTDHRSLEYFTTSKQLTRRQARWSEFLSEFNFTIVYRPGLKGTKPDALTRRRDYHPLEKGSSLSTAANPQNHRALLRPEQYLATATGDHTSDDDNNNSDNDTDTDTDNDNTTPRIDLSSDITLRFKNALEQDPDRGFYHKEAQNPQNHTFTYDESGLILYDDRWYVPKSDELRLRLVRECHDHPTAGHPGQRKTLQLLQRNYWWPHMKGWVNNYVDTCHECKRAKSRRHSPYGFLKPLPVPPYPWSSVSMDLIEGLPESNGFDCILVVVDRLTKMAIFIPTTKNLTAEELARLYLKHVFAKDGVPQSIVSDRGSEFDSRFFRAFTELLGIDLAMSTSYHPETDGQTERVNQTLEQYLRLYINYQQDNWYWMLPMAEFTYNNTTHSSTTVSPFFANKGYHPRSHFTPRDDSEVRTNSPDARNEVEGLADLHGHLREQMQIAADTAKHFYDKGRTKAPSFKRNQQVWLDARHINTTRPQKKLDHKFLGPFKIKRKISDMAYTLDLPKDMKARGLHDVFNVKLLEPYRKNKIPRRHQPPPPPVEIDGQPEYEVEAILAHKLDRRYKDPNFYLIRWRGYDTSQDSWEPTEALENAQDILRDFWEKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL08</accession>
    <name>K1VL08_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL08"/>
    <dbReference type="STRING" id="1220162.K1VL08"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="InParanoid" id="K1VL08"/>
    <dbReference type="OMA" id="TFWASAF"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="488"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="586" mass="63038" checksum="A62F8B1D9AE740B5" modified="2012-11-28" version="1">MAPTTQGKLQPSMAEVDRMLVEAGPGTHFELDHETIQGRKQLVWKNRLKMFGDRPLLSSPTPDGEAREQLSYREVRLRSQILAGWLWDQGVRVGTRVALGGLNSAAWVVAFCAVHIAGAVPVLLNSTLPAPLQKHCLLLTEPKITLVDGKLAALIQSILPELRARGIDPYCWDHGMECGLRRLEPSASAEAVRALDSGRATQSLHPESDGMIMFTSGTTNHPKAVLVTQRSALSHVPTAAFPVARAILRAGGSLEDALAAHDPPKEPSVMLVPVPLFHVTGCLSWLLKAMTYGHKVVFTRRWNVPDAIKLIVDERVDVIGGVPAIATSIIQSGLLPANWQFKSVGYGGAPPPAGLPEEIVRRWPNAKIANGYGMTETNGIITSLVGADYVRDNTSCGPPVPICEIRIVDPEDTSKEMPTGTPGVLMARGSMLMEGYLRNEEATRAAVSPDGWFNTGDVGYVDAEGFVTISDRAKDIIIRGGENIASGEVENAITADSRIEHAAAVPVPDKTLGELVAVAVTLAPGASATPESIIETASPRLRHAARPVFVMVFEEDFPRAASGKVLKKDIKEIVAREFAKLNRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLC7</accession>
    <name>K1VLC7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_04102</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLC7"/>
    <dbReference type="FunCoup" id="K1VLC7">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLC7"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_5_1_1"/>
    <dbReference type="InParanoid" id="K1VLC7"/>
    <dbReference type="OMA" id="KVEHRCD"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="202"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="570"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD01541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="648" mass="70021" checksum="903E5948E22E10B8" modified="2012-11-28" version="1">MSAETINGTAPTPAPAADAAAPAAPANPAPSTSTDVPTTSAEASSSKPQPLPTKHKKLSGYDFYRAIGSPKYVVAPMVDQSELAWRLLSKSPLPPDVAGPPEWIEAPLPDGPAGPSQPRKYARYAGGAHLTYTPMIHARVFSESRQNSRGGDPQFNITCNEEGNRKTLAGIEGGDRPLFVQVSHQLAGSKFPLTLDGWMSVILTLQFCANDPDVLLSAAKKVQNRCDAVDINFGCPQGIAKRGKYGSFLMEDWDLIARLISTLHVNLTVPVTAKFRIFPEVEKTVRYAQMMEAAGAQILTCHGRLREQKGPATGLADWDQIKAVKEAVSVPVFANGNILYADDALRCMEYTGCDGVMSAEGNLNNPALFADPKSPNAYVAATALARRYLDIVAKLDTPTAGSAIKAHLFHLLKPMLDEHEDLRVIFGKQGVDDKVAYYRAALDEVEKRFPPEPVTMPATPLEENGYRKLPRYIAQPYIRAQPISSEIGGVEEFEPGATPAGSPGPIGGRVHINTPCVGEKCGGNAAARCPTTACLLHCREIRAIAKGMDPAEAKKKALSGGLVGMGCEAHEAKQAERSKRKKEKQERYQERQRQKRQRRRSRSRERERERRRSDAAEEAAMNAAPAELTPAEPVANGTANGTTNGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLQ8</accession>
    <name>K1VLQ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLQ8"/>
    <dbReference type="HOGENOM" id="CLU_2348177_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLQ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="97" mass="10144" checksum="AE3C78CDFD614523" modified="2012-11-28" version="1">MSVGLPEQSGEEKGLRTERPAAHKTGPKDRGLSVSIRALYIDLAQEGAGAHRVGHAPDMFKIQKGYERHSSGHLNVNNNSEAAASLNGANGLAISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLR0</accession>
    <name>K1VLR0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLR0"/>
    <dbReference type="STRING" id="1220162.K1VLR0"/>
    <dbReference type="eggNOG" id="ENOG502RU8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070859_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLR0"/>
    <dbReference type="OMA" id="YEAEIDW"/>
    <dbReference type="OrthoDB" id="4573177at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33507" checksum="943930156B65E59D" modified="2012-11-28" version="1">MAPSFYESVTDFLDEVNHYASPISIIKGGVAALFGASTVAPHAIPGFEVKLSLSNTSLIGGVPCKGLRNAFHLEREWDERSYEYYDTDGKDLSAEGWAVRLRHKEDEDFEMTYKKRWRVTDGIHNALEQARAEGFDYGDKNYKAEIDWSYSKQTLSMQIKKRRSKKGYRHTDMPDDATGRAWLQEGIPGKLEHWKEHNWGNDILAQTRKHGPVTSTVWDGRWKGREIGIEILPVRGEDDHHQDIFAELSFKVKDMATAKKLREQMIEKLDKEGWLVHNDHLKTRVILDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLW9</accession>
    <name>K1VLW9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLW9"/>
    <dbReference type="FunCoup" id="K1VLW9">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLW9"/>
    <dbReference type="eggNOG" id="ENOG502SBZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144297_1_0_1"/>
    <dbReference type="InParanoid" id="K1VLW9"/>
    <dbReference type="OMA" id="NAFWAPR"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="129" mass="14161" checksum="A23B7958323DA41E" modified="2012-11-28" version="1">MLSRFSAAARLARLAFTPALRSFASTPISKAEEAESPAAPAPKKAARGISSLKEGTKMEGLSVLKDKEDPVAMADDKYPDWLWKLLDDPAAAKAKEGAKEGEFDFHAERKRLRTQNRTNIRAANFLKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLY3</accession>
    <name>K1VLY3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein, 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLY3"/>
    <dbReference type="STRING" id="1220162.K1VLY3"/>
    <dbReference type="HOGENOM" id="CLU_488516_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLY3"/>
    <dbReference type="OMA" id="QWNETEH"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853913" evidence="2">
        <location>
            <begin position="20"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="558" mass="61155" checksum="29AE5E4AD3C08029" modified="2012-11-28" version="1">MKLLPSLLMLLPIVQETMGIPFPTPGPHVIPPGAIRILRRKATSSCVPRPGNSTLPGNNTLPDLDQSHNHKFNDTDTDKDGDKDNGDKDRPNKCKNRKKNRKGRKKWDHDYWTDPEDDDDDDEDCYDDGQWDGDNGDWDDDKDDNGDKDGDKDKDNGHNGAGNQDGSNNHNGGNATDSGGNNGQWNGTDHGGNNGQWNETEHGGNNGQWNETEHGGNNGQWNETEHGGNNGQWNQTDPGGNNGQWNQTDPGGNNGQWNETEHGGNNQWNNTDHGGQDNNNHGTGDGDGDGDGDKDQDGDGDKDNNQGNNSGNGNNQGSHNNGTGSTAWVDPYNPSDWVPDDVRHINDEIPAAYNQALRYVPRQNDYASSGPDWLKLAKPNALGTYASLNTRRGGQATFYSLANPDENHGYDKTACGIDNPPDTYPLVALPMVNWNELWSGDSWDAPFCGHLVRVRYGNRSATAQVLDGCAPCGYNSIDMSPVLFYYLTDGKEKGDKLGILSQEDGFSWEWLDDPSTQRQEMPSDGYIYDGSVPVGSDSGYYDENGNAQDINDVWGDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLY8</accession>
    <name>K1VLY8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLY8"/>
    <dbReference type="eggNOG" id="ENOG502RDGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089014_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLY8"/>
    <dbReference type="OMA" id="ESTYHRK"/>
    <dbReference type="OrthoDB" id="17066at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="28367" checksum="F02ADF55E3562D66" modified="2012-11-28" version="1">MSRLASLQSTPSRRSSPSPSPSPAQSPMRPTETTHHRMLKMVLAEVCNVLSTWDDIVTHDGLKAGKSCIDEATEMDNILLNPEGPERALVGPHLERLMEARESLQGVLAKLERLLVKLNGLADQADRLFFEACKTQKYDFVLSDPLWLSWTFEDFGKLPWGLSTANFSVNSLSQLVSVHNRHLVEMDGLAATLMNPSTKFEDARSAIERWRDLGRGGERWETAREWEEVTQLELAGPNPKMEQDTPKRCGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMA0</accession>
    <name>K1VMA0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mating factor receptor-coupled G protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMA0"/>
    <dbReference type="STRING" id="1220162.K1VMA0"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112719_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMA0"/>
    <dbReference type="OMA" id="NICTIYS"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="139" mass="15547" checksum="A1CDAFFBF5C26B03" modified="2012-11-28" version="1">MSTPSEIQEKISAARREADGLKEKIRAAREQTADTSLRAMATETPPLARLQLKIRRTLKGHLAKIYALQWSNDRRHLVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYSPSGQYVSCGGLDNICTIYSLLVRTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMA5</accession>
    <name>K1VMA5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMA5"/>
    <dbReference type="HOGENOM" id="CLU_1074377_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMA5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="27361" checksum="8964133960499E22" modified="2012-11-28" version="1">MASSPSSADSDGLSAPLATMTVDTLGSPSSPAATTNPANDQEPGGTHAILHYAFTSGDIEVMSSDDVRFRLNLSILQQHSPFFRDLADLPLPPNSTRLVPFTNASALTLEILLCALDPAKDVRPVPSVIVFNQLCGLIDAYDMSLVGHGVVAAVEMSGLDLFLKYRFACSHNPERRSTGPWNASVTITSSPREAPTQGCSRRTIQMPSIPSGKPSRTGRWEAKTASTRSAGQAAVAPLLHSAASGKTSRAKLQMLCSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMC8</accession>
    <name>K1VMC8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMC8"/>
    <dbReference type="HOGENOM" id="CLU_2063128_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMC8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854239" evidence="2">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="119" mass="13458" checksum="032C7B056C489E66" modified="2012-11-28" version="1">MKLAALIITFFAFATAAPVILERGDDDFDRDMPTCMLHPPSLCSKRDVIEERGVDAIEERDVIEERDVIEERDNIDNEERAVIGNGKRDDADVDRDMPTCMLHPPSLCSKRDNVPDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMV8</accession>
    <name>K1VMV8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L18-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMV8"/>
    <dbReference type="FunCoup" id="K1VMV8">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMV8"/>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080024_3_0_1"/>
    <dbReference type="InParanoid" id="K1VMV8"/>
    <dbReference type="OMA" id="KIVALKW"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="17742" checksum="7EE9FD82A547C966" modified="2012-11-28" version="1">MGIDIRRHHVKKGNRQAPKSEDPYLLLLVKLYRFLARRTDSRFNRVILRRLFQSKTNRAPISLSKIVKLTRGSNPDNSKTVVIVGSVLDDERFAEIPKLSVAALRFSGSARERILAAGGECLTLDQLAQRAPTGSNTVLLAMVAEKWEGASETSAPKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN07</accession>
    <name>K1VN07_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000069">
        <property type="protein sequence ID" value="EKD05575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN07"/>
    <dbReference type="STRING" id="1220162.K1VN07"/>
    <dbReference type="eggNOG" id="ENOG502SBFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035170_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN07"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012181125" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="403" mass="41166" checksum="BED062F4C030E7BD" modified="2012-11-28" version="1">MKFLGLSLLASVALAAPAQLEARGNSQPENCDNPGRVISIILDSSGSTATSDHEKLRIAGGKDLVDYLTSASEATDKNKADTVSVVSFDSTPKVEYPQGDANEQAKKALDGVDSSGGTNIAKGLTAGIEQVAAANPGNRGGVIIFTDGLDSNTDGIVKQINKAKEAGIRVSWGHTNSPYKGGGSGLIGGILGGITNLITGGLNAMSGESGKLDQRISEAVLASGGTASIISNSQSQREFVQQVIKNGLTNNDGKCGGNDIGESGGPLINDVTTLGLCSKNAQAVFTYSPKSQHEQLTFAINLVSQNSPVNIQATYTNKATGQTSTVTVNKGQASGALQGEANPGEQVEVVINTSNADSNACQYSTVTNTVTQTATVTGPAPSSTVCICKCDAPGAKPMPKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNT8</accession>
    <name>K1VNT8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Regulation of budding-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNT8"/>
    <dbReference type="FunCoup" id="K1VNT8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306128_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNT8"/>
    <dbReference type="OMA" id="WCSAKDP"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="737"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="786"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="844"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="909"/>
            <end position="922"/>
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        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="963" mass="101993" checksum="932A50192B8D9F00" modified="2012-11-28" version="1">MRESNYTFPPSNRAVISINQMLYDRRALDTNSTLALLNNLCQLTYLSSTSPRIREVLTMDGGLERLLDILRDSCLPREPTMPDLWGLNGPCTARTINVDHAISLRHSLAFQCVVNIGVRGNEAIRSRVVQAGALDIVAQILESWLKKNGIAIHSSSLGSQAAVDALAAGVPLPGTASRRHRPSGSSRSHHHRDRGDRDQRDQQQASASQAPSQPQSQSQAQPQPQSPHPPAATVNAHAYPPGAAPPPNTLLSPAHATATGNAAGQPNSRGLQYVANLITNRLNPRQQPAEQVTVTRAPVTTNSVDTDVDMADGETEGGETDTAGDTDTGADISMDIEDSGAPSPDRDATIGPAAGTTTTPRPRLPLLPLQIGRRSPDQPQGTSNATSLSEDEPTTAIPRARSDNSLAMSNAQAAAETGRPTSGMASRLHQVATEAVSTQSSPMGSPTHHEHVEGMRGRRGTIVGRPLLLPPREQQPRTDDSEISDAAPDPDLARTTLSAGFAAAAANAAMEAATAVQNQPDNAPQPAIVEQAGTNEEPDPEILAAEQARFDMEAGAPPGQPGAAAQTPRVTPNDGPLQNTTVAELIAQPVQAQPAQIIIANGAPRGFQDLGAYVGVSLLLNPEGTNYSEDNILLALQLLAYLSKYPHVRSTFHHPRRPMHRTFDLGPDDTDYPLPQRPAYSETPNIFSLVERFTFRASPSDPHMYKIPSDIHYWAGVIMRNACRKDDARGGIRQCAYMSCGRWEVFPREFAKCRRCRKAKYCSKECQSKAWSEGHRFWCSIRSESEATETNATAGGEGTERGSRGGEGRGGGGGGGGSRRDPPPADDDDDDVDMDGGANGGAGARAAGSGTTQAAPTPLPTARGVTHLAGPPPAGAAAPVMPQRTAPLFAPSVDRPPNPTVTISPPPSASAASTSSETTPTRETTRRPSPDRSDDGVPSFLKSGREAGPSSTAEMNAAMLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNV9</accession>
    <name>K1VNV9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acetolactate synthase</fullName>
            <ecNumber evidence="13">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_03367</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="13">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="13"/>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNV9"/>
    <dbReference type="FunCoup" id="K1VNV9">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNV9"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_1"/>
    <dbReference type="InParanoid" id="K1VNV9"/>
    <dbReference type="OMA" id="QETDMIG"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="17">
        <location>
            <begin position="88"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="15">
        <location>
            <begin position="289"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="16">
        <location>
            <begin position="496"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD02311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="675" mass="73382" checksum="6480C3B1E6E95579" modified="2012-11-28" version="1">MLARPSRAILRTVPKASSSRAALIGQIRSRALNNSAKTAGAAAVRPSPAPTFQAPPNQNTPESPYAYNESENPNIRDGLDHSFVGLSGGQIFNEMMMRHGVKQIFGYPGGAILPVFDAIHESPHFNFVLPRHEQGAGHMAEGYARVTGKPGVVLVTSGPGATNVITPMQDAMSDGIPMVVFCGQVATSLIGSDSFQEADVVGISRSCTKWNVMVKDIAELPRRINEAFKIATTGRPGPVLVDLPKDVTAAILRTPIPAKAVQPGQSPYLPSNPLTRSPSKKQAGDAKFIEKAAELINNAKRPIIYAGNGVLSSPEGPKLLKELADRAGIPVTTTLQGLGAFDERDEKSLHMLGMHGAAYANFAIQEADVVIALGARFDDRVTGKVSTFAPAAKQAALEGTGGIIHFEIQAKNINKIVEAQVPVLGDVVESMAELLPQIKKNDRAAWLARCKANKEKYPFVFTPSKAGERLKPQEVVRELDAVAEEMGKEKFIISTGVGQHQMWACQYYRWTEPRSWVSSGGLGTMGFGVPAGTGAKVAAPEKIVVNIDGDASFSMTCMEKQTCSQFNIGLKTLLFNNSFQGMVHQWQSTFYQERFSHTRMVNPDFQKLNQAMGVKTWYCTNKEDLPRMMREFLEYDNDKPALMECIVSSEDVYPFVPAGAALQDQVLHPMLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPD0</accession>
    <name>K1VPD0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000320">
        <property type="protein sequence ID" value="EKD01332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPD0"/>
    <dbReference type="FunCoup" id="K1VPD0">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPD0"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2558470_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPD0"/>
    <dbReference type="OMA" id="PRINSRM"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="90" mass="10727" checksum="BA2B1C531DDED1A2" modified="2012-11-28" version="1">MVFLCKKCKKAFRKDMTQYEEADEYCPHCDNHYVIEAKEPKPMLGVEGEDARVDNRMLKDDREKEREGRSLFGRDLSDKIETPIWKTQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQB4</accession>
    <name>K1VQB4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQB4"/>
    <dbReference type="eggNOG" id="KOG1890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006249_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQB4"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="349"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1345" mass="148062" checksum="A707FB7CA124B9F7" modified="2012-11-28" version="1">MSSPSTPVATPMLKHLPPRLTVPPLPPQLHRRLRVRAIDDGLLLYPGTNSEPEDAVLIRYGIKAKVEAFAVPPADESLEGEVELGGVVAAYLVVFLPAKKPPTSIFPGDNGITPTDVTHEVNTLTDVYAIPLIKERAERHLGQMSRILRVPKAPKSKAKTSPKPKQKPPALNLKWPWQAGASSATSDDDGSSSDAESSSEDDESDIEARRRRSSSVAPEADEDLPTLPPAVDDSAESRMKKRFSLGWGKFTPKLGKAKPKDKIPPAKESATEVREEQPEDPVGDVEPEDVADAHDDEGGIEMTSPGLKVPKTDSAAPSSAPSRATTPVPKPALDVPARLELESKIMKQITRELGSGEFYYSYDFDLSHTLQDKRKRLARGQKSGALLEGLLSSANPTSEFFDNTPSETDRKLHSDPPSPGGSVKSAKSTRTTGSEIIEPDIHVSLWRRTDRRFFWNESLARDFIELGLHGYVLPILQGYVQASQFTVPIPPSPVDEAKLLEPPAPVPVDIVLISRRSKDRAGLRYQRRGIDDEGHVANFVETEMLVRAKVGGKVSMFSFVQIRGSIPLKWSQTPWSMKPPPVLDQPVDQTYSVANLHFDDLRKRYGPVTGKEAPVTNGYGELVGSLERPDLTYVPFDFHAKCHGMKWEHISELVNELDFTDMGYLWLLQGDELTSSCIDCLDRTNVVQSALARHVLKQMLLQLGITVDPKTCDVESVFNDTLKGDFVRTGKRDLQGMLAQSSARVLDNGEQRIGGWTLLSPAERNTKLSPKLEEKVLLLLALYVVSFNYSLEKVNEFTRIPLKSITSLQKGAYILSALQEAGRDPTENAGFVVTFAAADESTRYSTYSLDNTVATPPTPTSTISQASTTTGTDPLKSETKRNRARTLSFKRKSIMKLADVDPDTSEFFAFKALPREFVAQPHPEDDEDEEFTLEQNETCMATVDRIVKRIREQCAKVHKVPDDFVVDKDVVSVADAENATSLLARMDYAWVLTDGHETTLHGGGPLKEASRVFRSGFTDCYSRKGVEGRTRCPLPRLTTGGGGGDDAALSITDHVPGLGAAPVEAREGEVGSRGVALTVEHANLLGSIALFSIFQTPIDQLSQAIPVHRDNFCDPTRKNERRKRIPPAHDSAYITGPSRPLRYPIIANDFAAMSFHDLGRSPLSPPRSVGTTSSGSQRSNPSPTRGRAGSVDPSSSPSRAPQPTRGKLSPTQRAQLYYMRINEQSIYEGGVLRAFQWKILHPDEPEAKELFLQFRKMISADVPYKDRDGEVEKREAGEMWAELTRIIAAEVEERERKKSVSCERSWGAEERCPKLMTRIPSSSGEGASRSAAQDVRLEESGDQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQF8</accession>
    <name>K1VQF8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQF8"/>
    <dbReference type="FunCoup" id="K1VQF8">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQF8"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="InParanoid" id="K1VQF8"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="691" mass="78417" checksum="1764A65184576901" modified="2012-11-28" version="1">MPGKQETFGFQAEISQLLDLIINIFLRELISNSSDALDKIRYAALTDPSQLDTEKDLYIRITPNKEEGTLTIRDTGLGMTKADLVNNLGTIAKSGTKAFMEALSSGADISMIGQFGVGFYSAYLVANRVQVTTKHNDDEQYIWESSAGGTFTITEDTDGPRLGRGTQIKLFMKDDQKEYLEDKKIREIVKKHSEFISYPIQLVVTKEVEKEVPDEDAEEAKDGDSKIEEVDDEDSGKKKKTKTIKETTTENEELNKQKPIWTRNPNDVTPEEYSAFYKSISNDWEDQLATKHFSVEGQLEFKAILFIPKRAPFDLFETKKKRHNIKLYVRRVFITEDNEDLMPEYLNFVVGVVDSEDLPLNISRETLQQNKILKVIRKNLVKKTMDLISEIAEDKEAFDKFYQAFSKNLKLGIHEDAANRNKLAEFLRFYSTKSGDEMTSFKDYITRMPEVQKSIYYLTGESLEAVRESPFLEALKKKGFEVLLLVDPIDEYAVTQLKEFDGKKLVCVSKEGLELEETPEEKAELEKEQKEFEDLCKNIKETLGDRVEKVVVSNRITDSPCVLVTGQFGWSSNMERIMKAQALRDSSMSSYMASKKTLEINPQHPIIKELKKKSDEDKGDKTVKDLTTLLYETSLLTSGFTLNNPQDFASRINRMISLGLSIDDADVGAPEPSTESAPALEEAGGSMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQS7</accession>
    <name>K1VQS7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyamine transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQS7"/>
    <dbReference type="STRING" id="1220162.K1VQS7"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="InParanoid" id="K1VQS7"/>
    <dbReference type="OMA" id="AYRWYLT"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="203"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="650" mass="70925" checksum="9DBC6EF28606AED2" modified="2012-11-28" version="1">MEKGDAVDRMEKGDLTDRMSRQTGETLIASSPDNSPKEKTSVLNEKDEHDASAPPLVAPEPVPAPKRTQSAWSRLTGRTSPRSTSPVNPISPPSPSAAIHPGSAPAGPVRSRSLDTPIYVGGENPHIIGSMDRTLSHQPAAASLFGGVSPDSIDHEEGLVPVRSREEAEQREDERQKIASDPWSVKFEPGEKINPKNWSLGFRWYLTVLGSLLVLNSTFASSAPSGIMGDLMQQFHIGTEVGVLCISLFVAGYCLGPLLWGPLSEIYGRRPIAILSFIFYVGFQIGCALAPNTGAILVFRFLSGTFAAAPLTNSGALLADIWDSDYRGTAMALFGLAPFAGPSLGPIISGFISVGGASWRWVFWVTTIFAGTCLVLITFTMPETYAPVILKKKAQRLRKETGDERWYAPIERHKTSFKQRMNDIILKPFIMLFLEPMLLAITIYMSFVYGVVYLLFEAFPFVFVKNHGFNAGENGLAFLGFFTGGVICCIGYVTMMEPRYQKQCKRVAPLMPAPELRLQLCVIASWSLVIAMFWFGWTSYASIHWISPVIAGGLLGVGVLGLYTSLFNYIVDVYLWAAASALAASTVVRSSFGAGFPLFATQMYEKLGTQWASSLLGFIALAMTPVPLLLIKFGPRLRAKSKFSPNIETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQT7</accession>
    <name>K1VQT7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQT7"/>
    <dbReference type="HOGENOM" id="CLU_342952_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQT7"/>
    <dbReference type="OMA" id="GHEGEIH"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="88644" checksum="B360888FBF8ACBA5" modified="2012-11-28" version="1">MVSFRRLISHRRHHDPAAPAPPPEQADPIAPPASQAHPSQRTSDPPRVVFARGSFTGTPLTDTPEPGSLRSSYGSAVQPAPPVLPPILPSLPVGGPIAPGALLGGPARLSTDAGEVKESSSPVRAAHNREADVHSSLHGDIGVVHVEHPGETRPLLDTSSPSLDSNYSDPFKTPPRSHSNHDVGHKGAHIPTVIYEGDERSRTSTPNTHTPDASRQQSHHSGHSGHSGHSGHSGVSSEATERATPKQSDRPPLSLVHPADENPGKQPGDQVEYLQPLEAIDRISSAEQSGASTPAHFFSSASTPLPHTPRGEPASPPDSPHLSPLHAAGSLPATPDAPLREVSRSPPASRHNTPPPAAPEVSLAPIPSGPEGRHTPIPAAPWGAQKHSDAAPSAPSAASPVDPPPHDCTSHRVLLHGHRGHRGHKHAPETQTSYRPRPESISSTSPSSTEEQPQAPTEQHSRFHISMPRWRRDSTSSVSSDEEEVSGPGLRTLEIKADSEEMAAGTRSIAWCDDLKPFHGPVPARLIGGRFPPLELVAEGEKSPLVKAKALPKAGLKRVGSAISSVGSRGSRPGSRAGSHAGSRAGSRPASISGHDDVADNTFGLDLNDALQLSPSPRAVDAEPTNPTPDPTNVSAVAAESSDWLSAWNPPRPAPSKLNLSDPLSGRTYTASRLGASIGSKKIVKFFLGAESGHASNEARAYELTAHSGVTPKWYGAYGGFHPRIGSKGVLRANQVLLYALVMDETGEEVVVEKLWKKEKADPRRAIAKLYQTLHAHGVLHNMPAAEHWRSTKAGFRLVSFSEALFRDDMDEEDWEEVCRAEDRVVLNLLGLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQV4</accession>
    <name>K1VQV4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQV4"/>
    <dbReference type="STRING" id="1220162.K1VQV4"/>
    <dbReference type="HOGENOM" id="CLU_499846_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQV4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="545" mass="56656" checksum="E678CE41F553C790" modified="2012-11-28" version="1">MGAAAGGIGLLRSLGRGQVSSPSASHDSLNSPDAQRNVSGNTLEKHIGMGSPASREREGSLGTSHPSSTRLGLRMSHANSSGGRTQPSSSDARQSSMEDDDLFFNPPFDRNRFSSSTHETEYMTADTKGSGSGSLGSNSSGSRSWSSGSKGSKGSFPRSTRSNRVSTIPEESTPMPTPRIGGPIATGAGVNVNIGDAFGMHPNESQETHASAASSYYESAESGDLAEFGMNRRRRGPRYASNTSVDTFGGPYENAAYDEDDATVGRVPSLGRGSPARMGRGQSPAGPVRRWPLGAAPPAARSTAARSSMPAYIAAAANAAAANKRASLDSARTSYERPSMDRPSMDRPSIEVRQPTLESEMQLEDRPGARGLIQPLGGVKRRAAPPDITTGGAVGGDMMLSPFGPTTVTPTGSTFSHATHTDWTMSSGNVSTGPSATRSLGDLGSVGSADRPQVRLYNDFGAIDKASRSAPSLRPSDSSASEHGSHGSLPRGSRPRNRSRLALETTQESGESSEKEQSSSGEDGGGGGRGRTLSGAFAWLTRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQW6</accession>
    <name>K1VQW6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQW6"/>
    <dbReference type="STRING" id="1220162.K1VQW6"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_34_2_1"/>
    <dbReference type="InParanoid" id="K1VQW6"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="198" mass="23605" checksum="284FD42BC03C8493" modified="2012-11-28" version="1">MSRTVYVGRLPRADVEDHFKGLGRIKEVRLMSNFGFVEFESPDHSVCISNVSVIEYPSMADAEDAIRRLDGTEIHGVPVKLEIQVSSAYVRPDTPQEGGGRESWDRPPPRDYGRRYDGRDSYRPRERSRERPRYDRRDSRRDERYEPRYDDRRPRDDRYDDRNRERSPRRDRDSPRRRDSPRLDRDSPPRDRDGSPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQZ1</accession>
    <name>K1VQZ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQZ1"/>
    <dbReference type="STRING" id="1220162.K1VQZ1"/>
    <dbReference type="eggNOG" id="ENOG502R26K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987606_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQZ1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="29580" checksum="E11A4789EF1DFAF1" modified="2012-11-28" version="1">MSRSKPYSRQSSGSGPSGGKRDTDAAWKHDLHDSRPALLQRLGSGSPASSASSLKSRLGLDSSSPRERNSPSYAGRELLPGNSGQVHGLRSDSIGNAGKELLPAGKSARSGRGSRPRGSNGNEGAAFAANALGNLRRDRNDRSDRDRRDKPVSIAGAARAWVRVEHLAPGTTGADVKSAFASSPIQRAEVTSRPGDKDVVVELELPDEEAARELPLARAAAEGSVLATGRRTERGERQNVLGPDPDAAAASATEDEPRGPHWAPLARCEFNGSGSNLTVQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRK5</accession>
    <name>K1VRK5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000262">
        <property type="protein sequence ID" value="EKD03201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRK5"/>
    <dbReference type="STRING" id="1220162.K1VRK5"/>
    <dbReference type="eggNOG" id="ENOG502QQEA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_2_1"/>
    <dbReference type="InParanoid" id="K1VRK5"/>
    <dbReference type="OMA" id="HEVQQGR"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="10"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="32875" checksum="BAB16C523C66C9EC" modified="2012-11-28" version="1">MPRKIFVFGGSSVARALTEQPDKWEVYGLTRNPDSDAAKAIAALGVKLVKGDLDDPKSYAEGLKGSYGAFIVANFWLSYTPNGDGNAAAEIEYAHTIGAVDACVAAGVKHVIYSTLESFKPRVAIPHYDGKARVTAYLKEHGVPSTQLFTSYFFENLLSTPWKEEGGKKILQIPMTDDTPFPGFSAAETGLWVRAAFEDESWIGKDMDTSTEDLTPGKIAQALAEVSGQKWETQHLSDETFLALEQQIDYEWWINFYALFKGEMKRDTPASRKIAPSAMDLKQWLQTPEAKAYFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRN6</accession>
    <name>K1VRN6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRN6"/>
    <dbReference type="STRING" id="1220162.K1VRN6"/>
    <dbReference type="HOGENOM" id="CLU_529126_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRN6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="515" mass="58956" checksum="EA39E455453D9260" modified="2012-11-28" version="1">MYEGESEVDSSRYASDDSMPSAPEAGPSRSRMHRTSEDPFARKTRTKRRNLQEIMNTNPGSIFPWDEILFYVPEWLPPVIRQHILKRIGTTPHVQWAHAIISYRGESSAQRRELQRLPNVRAKETFILYPDWLARVFFSGLIVDPPRYLVWKDQNPLIAMGDLGSANDNLKTMVALEVLCVADNSPLLDMDEADIPFQLDHVRFMPVWKFHQLRGWARKSFFERQAEIAEEEEEDRIEEEMRRAARQGKRIVARPAKHSKKLKSSHKAAPKAAPSSAAQTEASAEPAPAAPKPTRPGSIGHNNETWQTRLSEKERRLLGIWLAWHCPDGRGRTSIHLFKAMTKHNFHDPEWTELARGRSAGAWRDWYRKFYKLPFPDGRSFGDRIEEWVEEVDGWESVDSALGDYKEAGNSQDGAAPRKRRATTPERPERVAPRKRRTVTTERSVPPASRKRQAASVEDQDYAPKSKVKTPSRRMSTRRTATPAAATSATPGTPNRHRQLVVEIPLRRSMSRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSV8</accession>
    <name>K1VSV8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSV8"/>
    <dbReference type="STRING" id="1220162.K1VSV8"/>
    <dbReference type="HOGENOM" id="CLU_090088_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSV8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29596" checksum="5AF160C9366913D3" modified="2012-11-28" version="1">MSQAPPPTTDTLRHEEVQEDPEWTEGDFKLIFSDGWSLKVWSYQLFFASATFRNAQSCSTADSPLEIQFTDPELESREVLSLFLDILTFRGEDVGMCLCLETSISLIAFLDKYDCGPVTEVFRLRLIRDVTENDCYSEAIFVLGAVLDDDRLCSAALLNEERFRIDRKLSKHFGITDIPLEALDSVPQVYLRALAEATPACDGKPCECFYETAHQRSRKFFNELWNLKDKLQDDRDRKRRLRMVNEALSVRKRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTA4</accession>
    <name>K1VTA4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTA4"/>
    <dbReference type="FunCoup" id="K1VTA4">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTA4"/>
    <dbReference type="eggNOG" id="KOG3066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067225_2_0_1"/>
    <dbReference type="InParanoid" id="K1VTA4"/>
    <dbReference type="OMA" id="HRAINQV"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27577" checksum="0CC0064925FEF553" modified="2012-11-28" version="1">MASADVAMPDASSAMTRREHLAKTFESYRAELDANVIILSRAITQLSKKLIFHLHRGATSPPAAREKNLKDARTKEREIYKNFVAVRDELASGTEEDGETLENFWKFSRPVFLYYLECGELVSLPHLQQALTDEEGEKDYILGMSDLTGELMRYATNALSTGDHETPLQLTKVFDSIPESTLHKLKKKQEETTRSLEKIEKAVCYSLRLRLVEFGDKPEVLRHLAKRAMDAANMNGGGEQREGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTN1</accession>
    <name>K1VTN1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTN1"/>
    <dbReference type="STRING" id="1220162.K1VTN1"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_0_1"/>
    <dbReference type="InParanoid" id="K1VTN1"/>
    <dbReference type="OMA" id="VYANNAW"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42091" checksum="31380727BAC6C9B5" modified="2012-11-28" version="1">MRWGSKRFDETVDVDVVSVDPQAQLQAQLDPQGKGLEVKKSAAERRFLLKLDIFLLTYGCLSQVIKYLDQTNINTAYVSGMSEALNFHGNELNYFATWFNVGCLELLWGIFTGCIAACKTASPIYGLRALIGVAESSSKVAWYTPLEMAKRIGFYHSCQAVGSMLSGALQTAIHESLEGKHGIAGWQWTFIINCIMTICLALIGPLMIPDFPEKPNPLAFWLTAEDKQIAQMRLERFRRVDINPINAKAFWRTIKNPALYMIIYIYVGMLIGVSGINYFQLWLKSLKNPDGSPVWGISQLNAIPMGGYAMQMAGIWAIALASDYFKTRWVVLIAICLIGIPSCIIMTVWNVPIGAKYYAFARPASLGLGVRYAPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTS9</accession>
    <name>K1VTS9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">A1Q2_01736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTS9"/>
    <dbReference type="FunCoup" id="K1VTS9">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTS9"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="InParanoid" id="K1VTS9"/>
    <dbReference type="OMA" id="WFPGTSG"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26511" checksum="8F45FDF9FE57E96F" modified="2012-11-28" version="1">MVKIEGYGDITPLSAEAEALVQSQDPEHFYKLGWVTGTGGGISMRKGELVYLAPSGVQKERILPEHMFVLPFAQSAVPKPGSKRDLLRIPSKKGLNESQCTPLFWNAFTMRDAQSCIHTHSQNAVMLTLLLGKDAKSFRISHQEMIKGVRLGGVGKTLAYFNTLEVPIIENTAREEDLTDSMGKAMEEYPDAAAILVRRHGVYVWGPSWESAKTQAECLDYLFEIAVKMLQAGIPLEGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUL5</accession>
    <name>K1VUL5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUL5"/>
    <dbReference type="STRING" id="1220162.K1VUL5"/>
    <dbReference type="eggNOG" id="KOG4324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281068_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUL5"/>
    <dbReference type="OMA" id="REDMFWA"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
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        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="222"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="193"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
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        <location>
            <begin position="783"/>
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    </feature>
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        <location>
            <begin position="801"/>
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        </location>
    </feature>
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        <location>
            <begin position="877"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="905"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="947"/>
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        <location>
            <begin position="961"/>
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        </location>
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        <location>
            <begin position="983"/>
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        <location>
            <begin position="1023"/>
            <end position="1035"/>
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        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1111" mass="117041" checksum="CF12C2EA17E8CAD2" modified="2012-11-28" version="1">MSDDKPDAAPAPAAEVSPPAAVVEDAKPATESDTSAAQVDAKTEAAEPAATTEAPASPAKPATPDEFVDATDAPAADAPATDSATTTAAAVPSTPPKPPTALPSRNGEHAEDKGAGTVELGSPIAEIKEKRKPTALQLDDVHAPPRSSIEVSAASVASHAVSRSRASSRASLQKRPWTPSLEHPPDSPTSSLISSLRQQLELLSDQATLLNSKLVDSISKHADLEDTIFGLQSEKEQQLRQIDELEKAKAQWEESMNTGLLVERSQIRDEMQRLAAGLVEEEKRRGTEEERRQQVESEVDQLTASLFDQAEERERVTVENLAAAEAAIKDMQAHLQSLEGAASAGAGPVHQPLPRRYLSSHPPYAEFLSLLSHLRALRPRTQRARELYAAPLVPNLLAQPFLARAIAEDHEPTLRLDAAPELSWLSRRNVGSAIIAGELLIEPAPAASFGPLDSINCAMCGTGVFSRSAQPTSRFSLKPFFGSSSTGSAHSPTSAQVYAFRTTEADAKAYPLCKNGWCLERLRSACALWHFVRTGIVAPVWAGEDGTDESSVSLHPPSPSPAHTQTSHHQQTITVTADDLLGEHPRIGRSVSQPAPAKPANTPPATEKKSGWGIGGFKMGWSSRPQTPSAPSVSSEVRKEDDSDGATMRTANSAVQTPTDADSTRAIYEGKTAREATAEQAAEAASGVDTTVKAEAEEPETKSELRAKDQEGQPASESARRPRSPSLATTDSEYSITTPPNEPKEPKETNPSSPADAAEVADALVKVNLEAEPKPEAAEGEATETNTPAEAAEAAEPTSEADTKPEATDADAETKPEATEESKTEGSPPPRPERKRAAPPPPLPKRSERRAAGSNASTPTAGHFPGTPTAPGPPSGPGSATPPSVSSAPGTPAEPTAAPAAQTEAEVKEPEAEQAEAEHAGAKHAEVKEAEVKAGEPAEEPTEEPAEEKAECKAESKEPTEPTAPLTPTTPKLPPPPRHFAVTSAHPGATATAAAEAATSPRSPRSAAFASNERNERRASAALSPSTSPRASTSLSRSNSTTAPSAPSLPPRVNVRHASNPASTGGAGKEESGPREKTFLVGEEWEVRCWKQIIRLKEDMWRARVGVVDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUS4</accession>
    <name>K1VUS4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1220162.K1VUS4"/>
    <dbReference type="eggNOG" id="ENOG502S8HH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759077_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUS4"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
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            <begin position="199"/>
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        </location>
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            <begin position="279"/>
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        </location>
    </feature>
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            <begin position="375"/>
            <end position="396"/>
        </location>
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            <begin position="32"/>
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            <begin position="52"/>
            <end position="66"/>
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            <begin position="70"/>
            <end position="81"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EKD00523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="396" mass="41693" checksum="DAD05CF059AFFFAA" modified="2012-11-28" version="1">MADPAPASATAENGAHLPPLEISTAPPDDARAATLSASSVSAPLVPSPACPASPAATTTSTPALPLGSQGHDESASGRRQEVEASVRAALLAGQNVIVDRVNFDPTQRGHFLAIAQQTGARPLSIVLKAPFDILRQRLLDRTDHPTLKDSETALKVLGRMRRELVYPQTYEGFQRVLFVDSEGDWTKERLVNTLEKLEREGTTGQKPRRGGYGGEYRGHGEIRGGGRGGYRGTFSGPRDVPPASRGGLGGFGGRGYQPAPRGGYRGGPAVDRGRVAYSRGGYQGDRPAGNATYRAPAGYDGSPRTGYRGNRDGELAFPISNHAAEVAWNGPTGSNISRYDAAGLPPRPPHPLSGSGAFDVMTGNHSRKFFTSSLARARPPFCGPSQSSSASTSEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUX1</accession>
    <name>K1VUX1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUX1"/>
    <dbReference type="HOGENOM" id="CLU_654140_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUX1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="420" mass="45825" checksum="AC64DB86A32BB90C" modified="2012-11-28" version="1">MSPPDETINLQGIAEAENALRAQILASLAPQYTFTCLVSPSHPLVPPARPNSVFSVDSDLSFQTAPEDLPQRSTTLELKSYLGSGSLFDSYAATLSGRPLIARILDPSLSPATLAIARAEAELYANLESLQGQVIPRFYGLWHGKLEDLVGRGEYERQLLVMLLENCGERLDKLFARGGGASVKPEDVRRLFSRLRESGEVAGDVYCLPGGQLRIAGLRPASRERAERTDRPRSVDTRLANAKQPPQRPHPRRPPPPPPMPKLPPAPPSPVSPVSPVSPPPPSPCQKSQAGQPLPEPPKSPSSSYMAGGCSPTSSVSSKPSVKFPDRPISLPFPPPVIDILCEQYPDGDNEDEEKVGNRASVLTFNQNARALIARSCSPPPALIGIEEKDGYDVQRELRKKKSWLRSKPSLRSLRLFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVE2</accession>
    <name>K1VVE2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000223">
        <property type="protein sequence ID" value="EKD04506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVE2"/>
    <dbReference type="STRING" id="1220162.K1VVE2"/>
    <dbReference type="eggNOG" id="ENOG502S6CW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_970399_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVE2"/>
    <dbReference type="OrthoDB" id="341353at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="287" mass="31149" checksum="4B2019157511F814" modified="2012-11-28" version="1">MTLASLPFVYGYLTGGIERMWYLGNNGWTRHLADVVVAFFGTYLFLATHLHSPPEKYRLTPSRPHDRIRRVPETGRAADGLDPPHRLHWRDGALRDVDAVLRLPDCEHHGAANVRSGHLQSLPGGAQRRALPHPHADHAHHFQQRAAGGCAASLLAEDHGGLARAVAKAAAAEAKAAAEEKEAKEAKRPPHLELGGSTPEDSPLVTPYAAPADAFIIPGVGPLPAIPTLSSLTEALPQAKANLSALHSEFSAAVHARLEEQRERLAMHGFLRRRAVYAEDNDDEMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWE9</accession>
    <name>K1VWE9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWE9"/>
    <dbReference type="STRING" id="1220162.K1VWE9"/>
    <dbReference type="eggNOG" id="ENOG502QPY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325461_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWE9"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="383"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="888" mass="100688" checksum="98EF50B3CB8E5040" modified="2012-11-28" version="1">MCGAKIAHIPITKTPPHRLHASRSTLARRLDMTTSRLSRPQAGRTIRLFGVLSLLAAPAAANVAMWHPSMYGFEAGVDDAGRAAEPLAKAKFGDWWLHGAKDQSPEEGQFLELPAGGQFKGELASKKSFTSFGNEVSCDEEGAVHDQIPRISCGLALAYVGNVEELHPANFTVISVRHDCTKPEVVFDIPKNLPACPEEGCHCLWGAADYGNGGWQGKPGADPLPDPQLPKACAGRPEECIKGAKQMVVWGQAEGNNVIGDGRFNDDFGYADGAQADIWELDNKKPVAKVLRRDEGGDNQNNGGNDGQGWDQKWYKQTWTLDELRQPWTDEERVYIEREAHQHWDNILSEKDYDYLDMNSLSVPAQYVVRKLRAQLWLATASKEEMPQTKQPGAAETKAPEQKPTAAEAKVTEAVKTQAQGAEQPKKTAALEPKKVEGDKTKEEASKQSPEDQKKVEEELKKKAEEANKKAQEAKKNPEDQKKKEEEEQKKKDEEARKKADEDKKKEEEKKKADETSKRSEAAPTSYSWGFANLNEYLDKLRREGQGPAMAQIEYLKESWKEMQADDNYPPDMIKWWQTLQDKFEPWKTPTPVTTGNPSVNTVRLNSIIDAIKNAGKLKRGEPHPTPAPRLPAHPKREMNIDSDKVLVNTLQDVQTTKLLLFNPNAQQEAKTEGVYTKQADGPAPTPIATLRGPPANAKKPSSTTSSWEPTGTYASLFGYLLDEVKHDPSYRLSPAQLRWLDHLKKSRDDGIWNGEWTKDFWTFMIEMRHQQRKRWLKPNDQGDIELQDWDTRTYRDKNDVERFLRQLEWSDDEIRGFNEAEVIDYNALVARVQELGGWNSAGMKKSDRYLDEESHLRWPEIYVLRKLRFAKKKLRDSVKQYFDDHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWH8</accession>
    <name>K1VWH8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWH8"/>
    <dbReference type="HOGENOM" id="CLU_1518927_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWH8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="180" mass="19906" checksum="25D267DE3A823892" modified="2012-11-28" version="1">MSTPVADYASDLVTRLWKRAEGSIVTQGILLALPPAMLLYGVHSTVRRNRAEAEVRERLRVMERDAASVVAAHKEVTRTLEELDHTLANMRTALRTQATSWASLQPDASAEDIANSYSKVEDLHCALMFDLGLALGNTKKIRQTVNRRPSHDAAPETDLVRWLIAIFSSKAVGCAKRQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX20</accession>
    <name>K1VX20_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX20"/>
    <dbReference type="FunCoup" id="K1VX20">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX20"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_4_2_1"/>
    <dbReference type="InParanoid" id="K1VX20"/>
    <dbReference type="OMA" id="IHVQLYV"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="233" mass="26680" checksum="33DE0B73FE83C9EA" modified="2012-11-28" version="1">MMRRRDVQGAFDDRRAQRHQHPPREQSHVMTIYSLYIFDRHCDCVYYQDWHRTRPVRPSANDKPDVHRLQAARAPGQRESIFSSSSGGQPNQPGQMGQHPQQAQTGSVVAGTARKSGPGLPFDEEAKLVYGVVLSMRNLVKKLSGKDEQFTSYKTSQYGLHLYETLTGYKFVLLSDPSTDSLRFVLRQIHTGPFVDFVVRNPLVEMDSRERGIDNDQFRAAVDKHIRSLTMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX58</accession>
    <name>K1VX58_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleus protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX58"/>
    <dbReference type="STRING" id="1220162.K1VX58"/>
    <dbReference type="eggNOG" id="ENOG502S6VR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068949_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX58"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF140">
        <property type="entry name" value="PEBP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854088" description="Nucleus protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="33361" checksum="CB3D9F886C877595" modified="2012-11-28" version="1">MLAALIPILLANGAAAELTPEQVQEAVGQFTAANLTNIVPINDIVGLIQGNWGTVDFSKAGYAFTTGQANAFPDKLVINPAPTKKAENVAYTAMLVDAGRAGQPDTPKLHWLINNIHLNDTDKAGGPYVLNYSDGTTVKQYAAPGPQDEGAHRYVFAVFNQGNDFTPPADYARADQVANVQDFDLQKYISDSKIGNVVGANYFTVDANDKTGNATAATGGVGGAAGANGTGNGTTGAGGAGGNSTVGGAGAGGNGTDGSGNGTTGAGGAGAGGNGTDGNGNGAGGAGGNNNGNNGGANGASGSQTGTAAAGQSSAAGNGDKGNSAAGMAAPAVGLALAAGALAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZI6</accession>
    <name>K1VZI6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran1-like protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000168">
        <property type="protein sequence ID" value="EKD04987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZI6"/>
    <dbReference type="STRING" id="1220162.K1VZI6"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023738_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZI6"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF31">
        <property type="entry name" value="PROTEIN CBG02007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="29920" checksum="2D0718FD5443ED9F" modified="2012-11-28" version="1">MDRLIEEPDCVYVVMDYGEEGDLFAMITKKQRILDGVDWLHQLGIAHRDVKPENIVCSKDGTPVRIVDLGLATSESTSFEFGCGSTFYIAPECLGEWSASATSYPTRTGSTWSVADPLFLRRILPISHQCLSILTQIFTLDPEHCITLDRLRELILNIDFFTDDAHVPASRREAAHHNVPVHVSAQYTDEVYDSPSLNAEPFRADSGSPPPQRSSSGFSDGPSPSTPRRGSSGTTPRVPWDSSLSTPVFEVLSQRKGQPLSPVPFAAPAVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZX5</accession>
    <name>K1VZX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000289">
        <property type="protein sequence ID" value="EKD02368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZX5"/>
    <dbReference type="STRING" id="1220162.K1VZX5"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_18_3_1"/>
    <dbReference type="InParanoid" id="K1VZX5"/>
    <dbReference type="OMA" id="PGSINTC"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="597" mass="63984" checksum="2EA74AD1256D4068" modified="2012-11-28" version="1">MPLDFKDLVVIITGGGGGLGRAYAHMYAKGKAKVVINDVSQANADKVVAEVKKLGGDAIAAVGSVMDGQKIVDQAVKAYGTVHVLINNAGVLRDRSFRKMTEKEFNDVYDIHVKGAYAITKAVWPLFRAQKFGRIVNTASPAGVYGNGGQTNYAGAKMALVTFAQVLDKEGVKYNIKANTIAPLAASAMTQTVMTPEVLSHLDPDHVAPLIGVLTARNGPDVGGRLFEVGGGYFAETKWQQSEGYVWKADDSFTPSAIDLQWPKVFDYSKATYPSQSDAARMMEVMKLQPSLPPNPQGPPPPITFKDYTVIITGGGNGLGASYARYYAKYGGNVVVNDISADAANKVVEEVNKLGGKGVAAIGSIEDDAEKIVKIAVEKFGTVHALVNNAGILRDKAFVNMTPELFNSVLDIHVRGTWKMCKAVWPYMHKQNYGRILNTSSPNGVAGAHGQSNYGTAKAAIIGFTKALAIEGRKNNIYVNALAPSAGTQMTATVWTEELLNTFKADYVAPIACYLTSRECKDTAQIIKAYGGLAAAYRYERSAGIVFPNDRPATPDQLAARWQEVITFDKRATHPTSSADSKGPIVANFANKAGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W005</accession>
    <name>K1W005_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W005"/>
    <dbReference type="HOGENOM" id="CLU_924980_0_0_1"/>
    <dbReference type="InParanoid" id="K1W005"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="300" mass="32862" checksum="E824DCD4232E9122" modified="2012-11-28" version="1">MVTPATDQSDSDMSDLPGLFVSPPKDDTSPTAPDTPTPAARAPSPVLRAPSPVDMTVIPATSQVHVPRAPPPALRARSPSPAPSTTSSFGTPDLSRLKPDDASDSEVIVTEEPTQTPDSSWGLARNHSSLRLYLASRHNPFLSSLSSPGSPSPSRPPSQPSQPPSPTTPRPPRAKRTKVTEEGETLLRRMHAHQAQVVHLRAQKAELLAAYAAWMQVYEASPGKDAKLWKVLWDAFTALDGAPQVTRAQRRMEKAEKLERLERDKQKRWAPKILAGDEMLRTLLCVLLLWLVWRIGVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W055</accession>
    <name>K1W055_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000141">
        <property type="protein sequence ID" value="EKD05172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W055"/>
    <dbReference type="STRING" id="1220162.K1W055"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="InParanoid" id="K1W055"/>
    <dbReference type="OMA" id="HIAQKCL"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="157"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="508" mass="56094" checksum="FB8F4DC14FDF53A5" modified="2012-11-28" version="1">MTTSPSPSSHDSDSVPYSMQVPIGISQLPAGPSGCNTLIGCFNHLSLNSSKSRFPTPPKPVASPLGTRDEQRKIYHGPKLSDRATGGPDAGPLIERFSCLFKDQYHCKSNPKGIVSLGVAENFLLQDECLEYFKTAFAKNFLTSDLSYGDSLWGSRRINRALSSFLNDYFHPAEPLTSDSLITGVGCSAVLDQLFYTLMDEGDSVLLIGPYYTGFDRDLIGRARVNLVPVCPPCEGFSPKSIEYFEKKMDELAAQGHRVRAVIVCNPHNPIGRTYPRETLLAYAKFCEERDLHLVSDEIYAMSVYDSPQSDNVPFTSMLSIDPEKELGIAFDKARLHVVYGMSKDFCANGLRVGALISPHNPLLLRAMANTSMLMKISSPADVIWSTLLEDRPTLNKFLATNRARLAEAAAHTRDFFESRGIEVYPSNAGNFAWVNLGPILGIETADEEKRIFQKLLDGGVYVAPGSGYHNPVPGWYRITFSVARENLDVGLRKMEDILGLRKITNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W062</accession>
    <name>K1W062_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W062"/>
    <dbReference type="HOGENOM" id="CLU_772050_0_0_1"/>
    <dbReference type="InParanoid" id="K1W062"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="359" mass="40338" checksum="F18A1735910EFC46" modified="2012-11-28" version="1">MPIDIKDIDDRSSMTMCSTASQEEANAGPSRWRRIRKWCLRVALLCADEVDKASVTSIEKKDGLYTPEEKPRGLNCIRTHVGEWNKQCIAKVRDWLLDARSASNQDIATEGLMQDSETDLDFEILTLSSECGSPITPTGLLMTQWEMVEVIQAVEDDGSDNSLRRMVARPPQLDTLSEVDEDIDEDIDEDIDAQEFSYPVIDFKERELGILYEEEEDGYDADNDDSGYTEDWGQDTSFESNVEPESMYSDNDYDDEIPPELAHVLQQISPSKQPWIRKRCRSAPSILNSQTFATPPATPPRPTRAATPSTPETVSSDVSMMDTSVESSFEALRRFWEERCEADSSFGSISSGSSAYFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0Z6</accession>
    <name>K1W0Z6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0Z6"/>
    <dbReference type="eggNOG" id="ENOG502S3N6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556899_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0Z6"/>
    <dbReference type="OMA" id="PNIFRSE"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="605" mass="65192" checksum="166EF55872C3D9E0" modified="2012-11-28" version="1">MDRLDRTTHSGSPQPSPHGAIGERASTPLGHLGHGRSSSLAQRQRADSLTDELDLASLIPHDQRQADLERDDLEDRERHGRAGFARFNLEAPHSRTSSPARQSRWEKDFVSRSRETSMRRQASTNSVGGIPPPSIPNIAVPPANLAFIDQSFPSPLRPTPPRHMSPHPDPVPSPNPAAAVSHHLQSLTSLLNPLLSASDDVARLRAEVDMWRAEWQRCDRERRRLETLVSVGDAGPVFTAVLIDGDSLVFDDAYIRKGYAGGQQAARALQAAAAGEGEGAMLVHVFVNKSGLGHALVKAGTCSWAVYEAFWQGFAAADPLWTVCDAGHSQDAVDAKIAAHLRLLAQNRQCVSVVLGAEVADTSSKVVPLRASPGGRAIYVPDLFRTTRLSIPSSPVQVGPPPVPGEGDSDPDVGEEYQGRAESDEDWDERKKGAPGKKYKPAQRAASVPTVRNLKPRPCHTFYLSPWGCKNGDGCEYAHHYKLNEEQTEELARLAKEIICPYVRSKRCHFSEDECVYGHRCPRGERCTFGDTCRFKDLPNGHGEDSPAPTPAATRPSTPAPAVAESQPASPSISTANAPAGPVPTQAQAAQAAQTQAQAATPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W212</accession>
    <name>K1W212_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD02973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W212"/>
    <dbReference type="HOGENOM" id="CLU_605782_0_0_1"/>
    <dbReference type="InParanoid" id="K1W212"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="464" mass="50942" checksum="DA46B64613A595CF" modified="2012-11-28" version="1">MKAPSPPGTLLDRRNRKLTSIEPTWRPGLEFVPSSARGQNSARPSAVPSLPSVATPTLKEQLRDKLNNFSFKRSTRSGADGTLDGESSTRNGKGKAKIKEEKEFEQWVPGVPRKKAVMTAAEALGRVNPPATQEYISRVALAQENVKRRDEHGHASSSGGWTDESGEWFSRTIRRPVSAYSPLDPVVSPSDRHIPTPSVLQPRASTRSSMPPPSSRRYVPRGSAPPLSHDAKTSMPPPGLHHPPQNGPARMSMPPLTANGGWAFSPPPSAQEPPPSAVLGYLPHERKWIQQQQQLPQYSPYPPQLSPFPPQQSLYPPSQHSPYPPAQDHQLPPNQHRPQYPQLPPQLYTDQLGNVTHGPVHGGLTGVNAMSPNTVPFSPYPEQGPYLPPIPIMSPMRPCFEPPTGLQLPPPPQVQRQGETAPPPRRQQTQSQNPLPAEPPLPARSSLPAKPPPSAWVDRFHMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4S8</accession>
    <name>K1W4S8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4S8"/>
    <dbReference type="HOGENOM" id="CLU_1379007_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4S8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="198" mass="21200" checksum="3B60B9E8543BA5FF" modified="2012-11-28" version="1">MQFAEIYFGIAFQPRDHARSHVDTSRPSLTCTAKRPDAMRPGATIPNPRLMQAGFCSKPQHAHRQPGPCVSGMSGVSVASQQIRTGDRWPRITERETFRFCDSCDPVRYAASALASREGQGLCSVPGFDRRGGGPASRGARVTPGVAAVQCPLCAAVSDLQAPASSALAVRLLVLGRWDKRKPEEPARNSVPGAAYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4W4</accession>
    <name>K1W4W4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4W4"/>
    <dbReference type="FunCoup" id="K1W4W4">
        <property type="interactions" value="1048"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4W4"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_1_0_1"/>
    <dbReference type="InParanoid" id="K1W4W4"/>
    <dbReference type="OMA" id="WGTSTRH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="45"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="265" mass="29138" checksum="9416B28DBA175C35" modified="2012-11-28" version="1">MGILQKIEDIEKEMSRIAKYRAQLLEPERKSGKPGEGFDVMKSGVGKSTLLSKATKTESAVGAYEFTTLTAIPGVLEYEGARIQLLDLPGIVQDAAKGRGRGRQVVSVARTADLILIMIDATKSDEQKAQLELELEAVGIRLNGHAPDIVFKQKAAGGITITCTVKLTKTDERTIRSVLQSYRIHNCDVMVREDVTIDEFIDVLLGTRKYIPALTVINKVDAVSMETVDRMARSGDGKTVMISCEMDLGLDWLLEAIWKELGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W537</accession>
    <name>K1W537_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W537"/>
    <dbReference type="STRING" id="1220162.K1W537"/>
    <dbReference type="eggNOG" id="ENOG502SHVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038717_2_0_1"/>
    <dbReference type="InParanoid" id="K1W537"/>
    <dbReference type="OMA" id="VFLRWDY"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852269" evidence="2">
        <location>
            <begin position="26"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="398" mass="43706" checksum="F565815853704BD6" modified="2012-11-28" version="1">MASPQFRRNATAAALLFLAAWGAYATYGLGAQNGLFDTIHASLDVENPYVPGGVSPLRTRYVASPVIDKHITVLISFFSYAIDPPHTKDVDVTSLVVMAHFCAGWALIRFEGWRLGNKQKLIAWTTAIGLFMQMTTPWAITIPLYLLVQLYTSPISNPEVGPSFVAVAADPVDLLLLPFCSIIAFIVPAIMMWYPGLPAYSHYGWDFTWQIFPVREYAIALVCKFILKRVLKAQAGGQHYLKNSRKAYDYSLFVATASQLIAIAACVLPAKAVPEAIRPWVADSTFANVFAPFWPWNSPAVGPSALINGNGLADLSRLFLQWDMLTGNTALLIWALHQHRRAVPNASLASRLKILGTWIPLGGPVGAAAALLRDRDDRLALRTAQRRAGEVVRETTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5I5</accession>
    <name>K1W5I5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5I5"/>
    <dbReference type="HOGENOM" id="CLU_883357_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5I5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="336" mass="36826" checksum="EFC09741AB741243" modified="2012-11-28" version="1">MSDSFKPNLVGSDGTKAGGTPLSTSQSGQPSGPEPQSANAPSTIKKEPTSVDASSFPVGTSTSAESSSSKEKPLLVAADVTTLAQFALLRATYKEIEAAKQAAHAKEAAEREARMAQPGWTRKDEARFGIRQGERESSKLFSKLWALGLPQPEPLQWALLELSADFKSAHAGDNQLAKFKVAKGREWFDDHRDLITRIEVYILMRFGASKKVNEDGIASYMSIESVHNLWIMCRHLRIMLKYKLKERKSLTLPGISDIPFWSDFWYRFPKSLRDLCQFDLSSNVSGGESSTANVDDGALVMTVGLGAPFLRWEPDKSSPEPSHADVFEALAAAKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6B8</accession>
    <name>K1W6B8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_08403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6B8"/>
    <dbReference type="STRING" id="1220162.K1W6B8"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_1_1_1"/>
    <dbReference type="InParanoid" id="K1W6B8"/>
    <dbReference type="OMA" id="QITRAIC"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="532" mass="57123" checksum="443B417D7720B734" modified="2012-11-28" version="1">MLSRLTPTARFALSFPARRGFASTAFRLNSKLYASADTAIDAVKKGDTVLASGFGLCGLPNTLIDALSKKPEINELTGVSNNAGAYVNGENKGLGKLLATKQLRKVIASYIGSNKPLEQMYMHGEIELELTPQGTLAERMRAAGAGIPAFYTPTGNNTPVQQGTIPSKHDKDGKPLEYPKPREQRVFNGREYCLEESIYGDVALIRAWKVDEAGNAIFRYTANNFATAMAKSAKITIVEAEHIVPVGTFDPMEIHLPGIYVNRIVQATTPKEIEIESVRPAEGEEDPAAGALGKGEARARREQIVRRAAKELKDGYYVNLGIGMPTLIPSFIPEGMKVWLQSENGLLGMGPLPTREEMDADVINAGKETDVAAPSREHTLTTSVTMAPGASVFSSDESFAMIRGGHIDVSVLGAMEVSAAGDLANFMIPGKLVKGMGGAMDLVSSPDQTKIIVTTDHTDKHGKPKIVQECSLPLTGSRCVSLIITDLAVFDVDRKNGKLTLIELQPGATLQEVKDKTGAKFDIGPNVEEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7R1</accession>
    <name>K1W7R1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7R1"/>
    <dbReference type="STRING" id="1220162.K1W7R1"/>
    <dbReference type="eggNOG" id="ENOG502SD4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035832_1_0_1"/>
    <dbReference type="InParanoid" id="K1W7R1"/>
    <dbReference type="OMA" id="IMPGHPY"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="54878" checksum="98B5C52AAB298E78" modified="2012-11-28" version="1">MSLTDALDRLAHESDQLKYHASQNTDQAGPFTSAYLYLEPGSNVLSLIRDAAPKEKRPFKILSAPNPPPNQQADFGVDKRPGVQLKTEAVLTPLKSLRARRGQPGELDATLRAADELLAAIADSYHMAKYQAHVRALAQQHAEQQRELAAIQAEIEAFSSRPAKKPEPEPEREELSVDDAIKAEEAALRELERSIAPLRRTAPASPASPRSPRSPMAARSPHSPASPKTPKSKTPARPTTTPSRALHFPGTTPRRPSQTPKGRFEPLHLFGTPRAKTPQVPPPALRESIRRDEPVGRSIFGPGAGRRSTQQQPLDASVRKEPLDASSTAKEPQSLASSTLQPPSLGTSANAPATPAHAPPKPAAAAPTPAPPTPAPPTPAPQTPAPAPPAESTSEIDATNPAVVSGVLADVMRMLTPAGRDVAATVSHLHAVLNAEVPSPPTAGAVTQEAVLMSAAALSLLRAAPSGGVLMPVLKAELATTARVRGWSEDAAQRTIYAGVGRKAWKIDRRAGGGGKVHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8T9</accession>
    <name>K1W8T9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8T9"/>
    <dbReference type="eggNOG" id="ENOG502S9H8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390383_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8T9"/>
    <dbReference type="OMA" id="SFIAYEW"/>
    <dbReference type="OrthoDB" id="2526823at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="75801" checksum="4179CD82ABE97A2E" modified="2012-11-28" version="1">MGLPPQYSVPGPMRPRDASTAASGTPERRSTRPATYSYPSLAYSLPSAYSTSQRHSYPRQSTPSHVPAGNPLLAGKALPATPDEVQAEEAARRYTGPLPPPRPMSSSNLAAQYDAGAGSGSSAVPLHPSIRRSGSANSIRGPSTRRSSRSSRSSGSAASPPSSFRLSQTAERTPAHSAFTEDSGLQAAGGTSGVSAHASNLASISHSRSNVEPPRSPPREHPFVSGRESASSSGSSPEKSERRRRREKEEKDRQRLERRRRRAARAAKSEADARYNDNRPTLSSTINLLLLPFRVVLMPLRVVLGPVLWHLLNALVILLVLAGLGWIAVLYIRHALSGLPEPLSTAVGLPFKLAATPACLLTGIACELSLVGKGWGWRGLGGGKKVDVAREVDVAAVSRGLSKEARHAKDIFESLTVLGDGRMTQGLGHVRIHELGIAISTGSTLDQREMVGLELIELANLASELTDEIVAINAMSVTTFSWLFWEVSVASRRTVSGGLCTSFPALVDERDLLGMPDGPPPSRVMARLDSLLSRLDRDLDRLYSAIDGAIPISVRGSAKGWELLHTLSSSSAELQAEKERYPGWQRALDSTLRFFKGGDPSKLQRISADLAITKGTIAGIDDTTKSLNRVQLDLKAFRSQVRSFKGGVIGVHLGTDEEDPLGAEMEMRILSGVVEELGAAVGRAKRRPVVDRDMGIDPPAEQGRIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W947</accession>
    <name>K1W947_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000112">
        <property type="protein sequence ID" value="EKD05348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W947"/>
    <dbReference type="eggNOG" id="ENOG502SQ8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380350_0_0_1"/>
    <dbReference type="InParanoid" id="K1W947"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="710" mass="79953" checksum="D1BB342F23F56D71" modified="2012-11-28" version="1">MDALIVAATGSPAVSSKQGSPTPEKPRLRVVERGSQACNECRRHKIRCHPAPDDPEHIKPCARCVRMSLECVFKKHNRGRKRKNPPPDDGGVATPIAQKQPHLDGPRSGATPSSQSYWGRGSPDRSLFPGVSKYPFVAGDSAQDADGPRGPPPMAQISLQNMVRGRPWDEEHEGEYYSGTDEEYVRERVTERPLHSVVGGAAGGDAITLGYVTLEEARELFQLFLKHFNPAMAIIDPVQCNHDFVRQNCPFTYHVILTIASRYMNLLPGSTAAAVPPSANSVHQQILVLARDQLMWAFAEAISNVDVVQAVMALCLWKEPDDDKAAFYFSRVVVLAKELDLGSEPPMHQVARMTDSERRELRHRQRLCSIFHMQFRQPMLITQLDPLVSTCQFWLKHTAPEYALMDTFSAFSADLRRRYLSYKELLNDPYPSPLTLSVLTKTINTEWEHTSEAWIREIIDAGGSPSYVHKPRVWYAALALNLNLQILNKTLRIPPHERIAPPPPTAAGAPTSVAQLRCIPAFHASLNNASTVLMRVHDLDKSQITFASDTFLHFSLYAATFLWSLCRRPQLYDFEDVEVEYIRDLILKVATAFEAASPYPGSSPALHAKYLRRLCRPRRQYESSEGTSDDLPPPVNREELEFVGDFGWVGVDLPWSSIDPALQGVTAEQPHQPHPEELERDRERERAERELRERERAILEEEPYVNGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE54</accession>
    <name>K1WE54_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000357">
        <property type="protein sequence ID" value="EKC99898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE54"/>
    <dbReference type="HOGENOM" id="CLU_055175_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE54"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="409" mass="46685" checksum="31B16C1E8951D770" modified="2012-11-28" version="1">MPAKATTPKLPAELLLSVFSHLRRHDLAQVCKANSYLRSLARPLFYRFGTLTKFGLHFPGAPSPYPFLDLPELGHARLSSDALERISADLRAIDLPAHLPSDCAAYRNLKMEDLPCHPEVLRIQCAVRVLEDHDEEAPGGDFPHIEPFPSERRCEHAVDGSCDCVHDCSYRRCEYNCFFRSFLVFNKTFDKVVLRDGPMAMFYYDDRRLPDVRPRKEFVAVLDSHDITKTGDHVHGCDIITWGLRPFWGSQVVTVVLWTGSPERGWIPPCINDSHERWISPTAAGNDEGFQRECHGMELFWADMGEQVGFLKESGPACTTVRIVNALSIIECHVNYDTGEYRKRRIRSTGSIESAFREGVRDALRGEDWGGDVQFWTMEEWVALSEWEDVFTCKEIEPFLTRLQALPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH63</accession>
    <name>K1WH63_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase III subunit Rpc25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH63"/>
    <dbReference type="FunCoup" id="K1WH63">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WH63"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073901_1_1_1"/>
    <dbReference type="InParanoid" id="K1WH63"/>
    <dbReference type="OMA" id="NERRFFW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="4">
        <location>
            <begin position="108"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="228" mass="25918" checksum="EE21893F27B2A610" modified="2012-11-28" version="1">MFNLIAVRTFGINPAVTIQDALNKNCVLEDFLADSRYANKLIKERGLALSVYDILTAEDGRVTWGNGQMYYKADSSLVPLNDVLALPWRGHSRQDSEHHAAVDPSFAQANKYSDENERRFFWYPGEDERKLDESELQNTLKAERFYYDTGEVIRFRVDSIEWNEHEPGPPKAPDTEEEEQKDPYESAGFRITAAVGEQGLGLISWWGEGAEEGEAEEYAEAEEVVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJC0</accession>
    <name>K1WJC0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJC0"/>
    <dbReference type="FunCoup" id="K1WJC0">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WJC0"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJC0"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="197" mass="22192" checksum="B4AE72D8FC0F641A" modified="2012-11-28" version="1">MSAPGKQYKAIGDDVWKRTDKVNAELFSLTYGALVVQLIKDYEDYGEVNKQLEKMGYNIGTRLIEDFLARTGLQRCQTFAETAEVVSKVAFKTFLNITPTVSFPPPQVPPTAGLKQPCEFVLTLEENPLAEFAELPRDAREGGLWFSNVLAGVLRGALEMMQVETRFLSDALRGDDTTELWVRLVRILDEEQPENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WL00</accession>
    <name>K1WL00_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WL00"/>
    <dbReference type="HOGENOM" id="CLU_1001789_0_0_1"/>
    <dbReference type="InParanoid" id="K1WL00"/>
    <dbReference type="OMA" id="HTWVGHD"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="278" mass="30925" checksum="7FB504273540E51B" modified="2012-11-28" version="1">MRVERRLFSLMVVAGLEERSSKLDTTISENNRLSTRIDEIRGDRDAARSKIAKLEGKLAEIKKELTSAVHEREMDAKQAAAELSLAQSRQRDAEERAERLRGEAPADAQARDAEFKALYDRIERRDVRLQNLQVELDKLRMNYAVAQEDIGEFTDDLAAAKAENAELKQELTRAQAEAAAKATAVEELTGQLDARAEEIAASQQKSAELESDMATLKDEHEALTHKHTSVIADRDSYAATVNATRAELQARKFGSAPPPNWLLSDMNHAQWPSGSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WN60</accession>
    <name>K1WN60_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WN60"/>
    <dbReference type="FunCoup" id="K1WN60">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_2_0_1"/>
    <dbReference type="InParanoid" id="K1WN60"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="170" mass="18808" checksum="0B542642BF8D56DD" modified="2012-11-28" version="1">MPCHVECHEDHDHDIPLESGPQDSLYKVVDTEHVRALNADGGPEKGKVVIKDWANRDDETIFANGAGLDFSDAEDREPTQTFEVVDTREPAEYQVKAAKFASVTSLALFFPHNISEGDDDETTRVYYVGLRGSWRPLPNALGQIVYEAAPRPTDHKVKGDAMAAAPRQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRS5</accession>
    <name>K1WRS5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromatin remodelling complex ATPase chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRS5"/>
    <dbReference type="FunCoup" id="K1WRS5">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRS5"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="InParanoid" id="K1WRS5"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000036">
        <property type="entry name" value="Chromatin remodelling complex ATPase chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000382">
        <property type="entry name" value="Transcription activator snf2l1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="497"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1069" mass="122546" checksum="57A62C7EE05D4CF9" modified="2012-11-28" version="1">MDPSVSPCALQNPLLAAANASSNNADDDKLSDYIPDSRDLSMSRAASTSGSDQHHINTRPQTPEPEDELASDEDIDEEAIAGGSRRQDEAAARKAAKAERQANIGEIGKKRGALEQAKLADSMKRFNYLLGQTELFQHFVDLKRDPEFAAMLDEQLAASASKGKKKAATRMATMKPTSSRRARLGGKMRDYQVQGLNWMVSLHHNGINGILADEMGLGKTLQTISFLGYLKFHRGINGPHLIVVPKSTLDNWAREVERWVPGFRVLVLQGTKEERAELINSKILTQQFDVLISSYEMCLREKSTLRKFSWEYIIIDEAHRIKNVDSLLSQIIRTFASRGRLLITGTPLQNNLQELWALLNFILPDVFSSSEDFDEWFKSQPGDEPDAVVKQLHKVLRPFLLRRVKADVEHSLLPKKEINLYVGMTEMQRKWYRMLLEKDIDAVNGAGGKKEGKTRLLNIVMQLRKCCNHPYLFDGAEPGPPYTTDEHLVDNAGKMIILDKLLKSMKAKGSRVLIFSQMSRVLDILEDYCQFRGHKYCRIDGNTAHEDRINAIDEYNAPDSEKFIFLLTTRAGGLGINLVTADIVVLFDSDWNPQADLQAMDRAHRIGQTKQVYVFRFITQDAIEERILERATQKLKLDQLVIQEGRAQQAQKLANNKEELLDMIQHGAEKIINSSTNMMIDDDIDEIIKRGEDKTKELNSKYAGMDLDALNNFRSESLINTWEGEDFAAKRQKMIWIEPAKRERKGNYSIDQYYRDNMRVTAPKSDKPKVPRPPKQVNTHDFQFYPPRLIELQNREYDAHLKAQNYVVPAREPEEGETAEQVETERAEEQERINNAEPLTEEEVEEKESLVDQGFGEWKRAHYQSFIKSLERHGRDAMDKVVADMAPEKEEEDVRAYADVFFERYTELKDGEKAMDRIKAGEEKLREQAERIAALHKKVKAYNAPMQELKLQYGQNKGKSYSDEEDRFLLVRMHHHGIDRDDCYDLIKRDIGEWPLFRFDWFFKSRTPEELRRRGATLLLCIMKDMKDDEDKKPAKGGKKRVLDDLKSTNSRDTTPSAAGDKKAKKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WS78</accession>
    <name>K1WS78_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WS78"/>
    <dbReference type="STRING" id="1220162.K1WS78"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039535_1_0_1"/>
    <dbReference type="InParanoid" id="K1WS78"/>
    <dbReference type="OMA" id="KETPFWT"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF161">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="30255" checksum="645A9AA1000E0173" modified="2012-11-28" version="1">MPPPTNDPNFPSNLNINPLHLEGTNASADADAHAQAESISKYGIAGRVWEASGPLLEYLTPENYDKFDPPCSFFAKDRGPVNVLELGSGQALASLHLASHLTPKDTVVLTDLENVVPLCQRSIDVWAEREGSKDKAKVITLPLGWGDELAEVGKLLPFTHLLLCDLVTEPESIPDNEGDTFGPEIIMAWKSRSFNLEESFFDAFARYFSMTPVLGPRRDPEVKLFVCQRWKINEEWKLPEQKHVMSPPKGVVLPARTFGLAEQVFASLEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WT40</accession>
    <name>K1WT40_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WT40"/>
    <dbReference type="HOGENOM" id="CLU_052874_0_0_1"/>
    <dbReference type="InParanoid" id="K1WT40"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="303" mass="33984" checksum="2F8EEC57025D386A" modified="2012-11-28" version="1">MATLLSAPTLSASQFAEFIEPAPLYQCPRSATPTMSRPRLTRDSSCSLYPSPSFGTELYRAPTRDCRDRRRDSTPPSPSAKRWSISLVRPRLRRSESDEPPRRSSRSKSPKRAKSTKSARSSETRPDSTEHRYSVFSAFGGFGAPLKKVENHTALVEARLDAPSPQPLPCLEACTGPPSPAVETFSSTATTLFDEPERDPFFDDDGIIWVVPRSRRGSRASSYSPAKPKCVMQHSTPEPQSMADLKRDSYGLHDVLNVHEVQPVPSKNRVRIERISNWGLPSSPREDKVWSKLSVTWWRRKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXA6</accession>
    <name>K1WXA6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000107">
        <property type="protein sequence ID" value="EKD05354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXA6"/>
    <dbReference type="HOGENOM" id="CLU_947276_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXA6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="294" mass="33336" checksum="CA4F062EE3A5F349" modified="2012-11-28" version="1">MSAPVITETPVQTANLPSNPDQTPGGGGVVPVTPVTRDRPQTSAPAVSPMGLTLPGQQVTGVAPRVYISPIWELNPTALKHLGLHPSHTAALKIPHMKDLIGRFKRALVQDISKRGAVRKLQRQVYEDVQVHFQALPFDKRMRVFIRTYLKGLANPEDESIPHLTPDQLVTCFATHYYKEHPREVIIALRTQLTIPPEEEYWTYAVQPWHTSTFSDHCWEEFTKRFPSSLSIPIHRILTLEPPIDDYPHDLPYDEDIDQSLIYKALRVTLANAEFRVAFVRALYRDVEPQEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1V032</accession>
    <name>K1V032_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium-hydrogen antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_08412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V032"/>
    <dbReference type="eggNOG" id="ENOG502QWRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024407_2_1_1"/>
    <dbReference type="InParanoid" id="K1V032"/>
    <dbReference type="OMA" id="TWAITLC"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="38"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="337"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC97254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="470" mass="49185" checksum="ABE2317F9B64EFC5" modified="2012-11-28" version="1">MWSFQYHEPSTTAALILVSFLYLLNVFGWFAQVLLSCGLLGQIFLGIIYGTPLAGLLPQSLEESLVGIGYVGLLLIIFEGGMQSSLMHLKATLGLSVAVALTGILAPMALSFTLMPMSGAPALHAFAAGSSLASTSLGTVLGVLAPSVLGFDLRRTMLGATLLSAAIMDDVAAFVISKVLQVIGAGAGGAELGRNIGRTLGVTLGIAFAAAVLARWVLKPAYLWLLARPTLWRGKSWGGTHLLIAINAALFTGAVAVAGYAGTSLLYGVYVSGLCIAYMCDSNVPADMGTGLPLAESHAPRLGHPTSESATTNETSTMAVEEEASELSLIDAFDATVPPVLNTLLLPIFFGSIGYSIPFIPLWRGTIIWKGIIYAVLMTAGKMVCGAWIFALHGQKAWRAAVFLGMAMVARGEIGLLISQIALHTPDPLLSDDEFLIVTWGIILCTIVGPLAVGVLVKRWGKLVLAGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4P4</accession>
    <name>K1V4P4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4P4"/>
    <dbReference type="STRING" id="1220162.K1V4P4"/>
    <dbReference type="eggNOG" id="ENOG502RYMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445632_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4P4"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="66980" checksum="B78C822BA179F5E9" modified="2012-11-28" version="1">MSDPLPRTAGAQHIRIRKSHSQPDYGTMPVMTKVTVQTVSHSGRHHADCVQEGLPSSPSQAKAAAASVQDRSRSLTDPSYLNHLPVHSPPHCIVQDTICTPFLDTPQAFRQSPFKAMAKDFAFLIKNIGLVPSILLPINNSPIDRHIRSKGILSGLFQVGLISTSLVLTVGAVTSFFTSIPPMAAWVPVLTGFCWVGLWLQGGRVKESDGAVNFVEGHEKEEWIYINGIATDGWTAEATADYLQNLFHRPITGVLNKTLGMWFDLIECILQRDLFWTTQDIRSGYEERIVIIAHSQGGIICSAWVDQLLCDFPADTLAKLEIYTFASAANHLSRPLYLAKTAEIADAKTMLNNCSKMSWDEVKTCIPAAFQDAVHIDGAGNGTSTHGGNSPVVSTTLRGDQVGLRALKATQPFHRVEHFANENDFVARFGVLGWSPPMPKEQYLGPQDRIPLEKGDFGGRVFMRPKTSGHLLLAHYLHPTNSILDDPVVRAHSRLVTYLGGGNSLANSNVLSGSPVADTPSSVSETTASAFAKSQFSIKQRELQKNGSKQSLEEETDEVSENVYHVTNPQDLPDTRFSGAVLESWVLCIIAASSSTSPSRPPNPEIRVWTLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1V577</accession>
    <name>K1V577_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V577"/>
    <dbReference type="STRING" id="1220162.K1V577"/>
    <dbReference type="eggNOG" id="ENOG502SKDC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568817_0_0_1"/>
    <dbReference type="InParanoid" id="K1V577"/>
    <dbReference type="OrthoDB" id="2591431at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851870" evidence="3">
        <location>
            <begin position="31"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="480" mass="49808" checksum="2EEBDCBA88C31F94" modified="2012-11-28" version="1">MPSSRRSSRRSLPRLPLVLAAAAMTAPAYAADPVTLGKQTFKFSLSEVSQCGQMTVTWQGGQGPYHLITVPWNVKDSAQVFNVSVPQKDGNGPWTHTFDYKQAVGQQFVATMYDSSGWGSGGVSDIQTVKDGDSSCLTPDNKDMPIDGKGFWMEPTKVEEFLPCTTARFAWNENFDLPANVAGLVPAGDTFEIPITKDKQSVDWIVNAEGGTPMVFVVLTSGKYGTAGSLSPLKVGASTQNGCLDSSSPGTTGIPQPVGSQTASATSGSGSSQTGTASPTASGDGSQAGSGSKSSGSNAGTIAGAAVGSAIGALLLAGLVLWCFLKRRKQPKDTHAVSIDLQETDESSPMRRNAANAAGYDADSRDPYLNPYPMSVPAPSFHRGSVATSSDASGITGIGSGSGSSTNLTEKQRLQQMEAMAASSSRYQHSAYGMSEEVDSEAVGPIAMPPPSYDHVLRVTNPSPQPPPGGSPASPEPRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5I1</accession>
    <name>K1V5I1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5I1"/>
    <dbReference type="STRING" id="1220162.K1V5I1"/>
    <dbReference type="eggNOG" id="ENOG502RZIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_5_3_1"/>
    <dbReference type="InParanoid" id="K1V5I1"/>
    <dbReference type="OMA" id="PLDPWYF"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="281" mass="30947" checksum="1A2B97A6CED3F4D2" modified="2012-11-28" version="1">MTSPTAAQPALANHTSQNYNEHASFVYSDKNTAPILRLLNAQSGESIVDLGCGTGQLTEKIKALSWPDAQLSFARENGNALGIEYTRGDIQDYRTLDASLEGRFDAVFSSATFHWCKANPGGVVETIKWLLKPGGRAVFEFGGFQNTVGVRGALHDCLRRRGYDPAKADPWYFPTAEQYSALLQLHGMSPSDVELHQRPTPLTTDLFGWLKTFARRTFFAEFSDLEANSMMEEVVESCRPDNYWCDAMPGLGIKPPVGATGNEGWNVHYVRLRGSATAPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6A3</accession>
    <name>K1V6A3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_06155</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6A3"/>
    <dbReference type="STRING" id="1220162.K1V6A3"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_7_0_1"/>
    <dbReference type="InParanoid" id="K1V6A3"/>
    <dbReference type="OMA" id="TQLVMKW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="450"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="616"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC99539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="968" mass="106988" checksum="443DB7311640FE77" modified="2012-11-28" version="1">MTKTLDYSEGSTPIPGPAGYPLIGNLLDIDMSQCFVSLNALHKKYGPVYQISFLGQTIIMVSSPDVVHVLSDEDKFHKHIDPTLLAVRGFAGDGLFTALHGEKSWDIAHRILVPAFGAISVRKMQEKMLDPLGQMLMWWECHAGEPFEAADQFTRLTFMFYAATSRQWDTDIALLNKVCDEIISERRNDPMPDEHDVLDRMLFGKDAKTGEGLSDENIRYQMITFLIAGHETTSGLLAFATYYMLKTPGVIAKMRSEVEQALADVGGAFAELAVGKLRYVDAVLRETLRLHPSAPFFIRTPNSEQGARLPGGYHVKHGQAVAISLHALHRDPEVFEAPEEFRPERWLDGTTYPPDAYKPFGTGGRACIGRMFAMQEAALAMALIVDRFDLSLADENYELQIQESLTIKPVNFNIKVAPRKKTGLLRELMTRSTVAKEEEAWKPVSAKGKMHVLFGSNNGACEALAGDLAAEYRQSGFSVTLDSLDDAAPDGKLPTDGTIVLILPSYDGQPAENARDFVASIANMEPGSLSGVEYTVFGVGHRDWAATLHRIPKLVDSRLSELGAERLLPISLGDAAVDLLSDFEDFSARLRDHLEIDVTDISAWSIPDSANCAPVTGFTLGRVMKQTKLTDGVMSIAIQADQPWQVGDYLAILPKNPASEVERALRVLGLKGDDHIRSPMAPGPLRAWDVLESYLELGTIIPKRYLTILPKWALSSASRLAAMADDYATVRLQRLSLIDVLERFPDVRPPLGHVLYALPRIRARQYSIASTPPGLELTYSVHERGVASRYLASLSEGDAVLCATRRSTFHPPPAQNTLVMFAAGTGIAPFRGFIAERAERARLGEKTGGTVLYYGARDAAHVLHDVELRHWVRNGVLELRPTLSRAERPKYKLVEGCRYVQDRMWAERTDISAWLEGGAAFYTCGGTEFASGVRKCFTRIIAEKEGAEKAEDEMAKLGERFKQDVFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V730</accession>
    <name>K1V730_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V730"/>
    <dbReference type="STRING" id="1220162.K1V730"/>
    <dbReference type="eggNOG" id="ENOG502TIAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1611978_0_0_1"/>
    <dbReference type="InParanoid" id="K1V730"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18253" checksum="DACF3796ECC9EDF7" modified="2012-11-28" version="1">MAATSTSTSKTDGESRPIRVTTGGHVVKYAERVIALLEAGSPAILTTQLSTEPKANSTLHPATLAIPRLISVAEKVKREWLKTHDEVWQYNVSGNMKSQERPSLERVLSGKTKPKMAHNPYLEITLSGSELDLEGATVQHERRKKEKRKSDVARDDVQAKRARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7R2</accession>
    <name>K1V7R2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7R2"/>
    <dbReference type="HOGENOM" id="CLU_1526241_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7R2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="22952" checksum="E0A772635804FDDD" modified="2012-11-28" version="1">MPGENTPIRPRDPGHRTEVKQYAVTSCVWLLLLGIVVFIQGGLTGSLFRQLVEAALWWNAAPLNKGWVAFQICWDIFYPLALWRLSSVARLPDDAAAVPAYDERKSSFQYLVTLRDSTIGQLGLTLFLAGFTLGLIPWRSEYFRDYRLIGAAFFLVALLPAALIVSRCSSKRIHPAMADGLRGGWSAVRKWSVRTAALCQLGKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8U5</accession>
    <name>K1V8U5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8U5"/>
    <dbReference type="STRING" id="1220162.K1V8U5"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="K1V8U5"/>
    <dbReference type="OMA" id="HKHMEDA"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="67"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="389" mass="42638" checksum="1A116C67EF2DF2D6" modified="2012-11-28" version="1">MSVRALVSTTARTVARTRIAPQATRYTPVSAALATRAFTQPQRTFSSTPRIMADGNMKCILIKDGKGPVENLYMGEEPVPQPKEGEIQVEIKAFGLNRMDIVQREGRYPLPPQASKTILGVEFSGTVTKVGDKATKYKVGDAVFGLTYGYICANERMCLPKPDNLSWVQAAAIPENWLTAYQAVFLEGNMKKGANVLVHAGASGVGVAAIQLALDVGEATKVYATCGTNEKVKFLNDEIAKGDKRFKAINYRTQNFAEVIKEDNAGVDLVIDFVGKNYFNQNIEALNRDGTVVYLAFLSGPVFDKANFGPVLYKRLTLKGSTLRSRDLEYQSNLLGQFEKNALPKILDGKMVIAVHEVFPWNEVQKAQKEMQDNKNSGKVSIGGRRGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9M4</accession>
    <name>K1V9M4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000336">
        <property type="protein sequence ID" value="EKD00655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9M4"/>
    <dbReference type="STRING" id="1220162.K1V9M4"/>
    <dbReference type="eggNOG" id="ENOG502S8AZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365705_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9M4"/>
    <dbReference type="OMA" id="ATHYTHL"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF21">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="87042" checksum="E71E0223A6563A07" modified="2012-11-28" version="1">MLLPITKLSAARIRLPRQATPSQLSARFYARNADAAPVKLRGAFVTPTPAPERETRSIDRSNVRELDLSRKSGSSGNTAWRDASPPSNPRRDSFRDSNRSGRDDRRPGGRRGSIRHDRKDEGPYYFSQTIKKWIERNEIPNKPLTGRQVEEVTRMITSARPDNVNAAVWNLVLALLGRQGQFGNMWKAYNQMKKRGTMPSSRTYTVMLNAFAGVAHGGVAQKTFTPQTPPEPLTLRRVNAIYEHSQRHVQKYLKYANGEGLERDIEADEDREGFVNEAQVNIMPTNAYLKFLSRYGMWKEMQTVFLAMDPHGPLAPDQVTYATMLNTINNIDHYRRASAGREGAVKLPAIEPGPQARLLWDQAVRALHPATAGRKLDEGVALAALQCFVAGRPEDKRFAETLIPRLWGFSAPNAPTVASLATPQVAEKDNSLPRLRLDVRSATQLMSLLVRLGRTSVSAHYTSQILERDIKFDMPALRAAIHNLAAVHDVEAAMNVLDQNSEAWPLDVLNAVLSAARWSKDWDTALSVYRRFTHLPQGVEKGNYKGQYKWESPNGRPTDSRGRRWIKNPVEPDLQSMDLLLRAGLEAGIPATREALNIYKYYPRERWYTITAQGELCDVKDHIPNPGVNTRRKIEERLEFARTVERAADTLQFKAKDKKEKEDMQKIIDDVKRVMERWKDLKNIAAQEKEKDGARGRESANRSGRPWDKQSNRRQDSEFPKRRTGDFQNRRRDDDRLTDRQRDGIYARRRRQEERSGESDDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA71</accession>
    <name>K1VA71_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_04788</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA71"/>
    <dbReference type="FunCoup" id="K1VA71">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VA71"/>
    <dbReference type="eggNOG" id="KOG2762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035382_3_0_1"/>
    <dbReference type="InParanoid" id="K1VA71"/>
    <dbReference type="OMA" id="DWETYMI"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD00915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="450" mass="51308" checksum="2221C74511D16C83" modified="2012-11-28" version="1">MPPKKAAKTQTKASPKKRATIETTEEVVVEQPTKYVDLTVANVLSDPVAVANSVLNDRRYYWLVAGLLALFQLVLGIAIILKVPSGRHVPVGRARLLEDRRRDRYPAGHLYIYTAFHKLLPAHGRERPAQFIFLGVETVTFLLAAQIYYLAGRTKHVPQWTLIPLVLSKRSHSIYLLRLFNDPLAMVLLYSAVVLFQYDWWKIGCFVYSLALGVKMNILLFLPGLLVLLFQYTGFFETFKAVVIIIFVQLGLPSMHFLDDVPNIIAYFTSAFDFSRQFLYKWTVNWHMLGEERFLSQKFAKGLLIAHVITLIAFGWCRWNPVPGGTPAVLKRGLFTLRNMFKPAVLPGQLTSHLLFCSNLIGVAFARSLHYQFHAWYFHQLPFLLYFGGSAGLLAVLEKAWDTYPATNKSSLMLNTAHIVMLAGLWYMNAPGRQQRQTQQQQTTLQKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAF0</accession>
    <name>K1VAF0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 2 sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAF0"/>
    <dbReference type="eggNOG" id="ENOG502S8EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068418_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAF0"/>
    <dbReference type="OrthoDB" id="2588322at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868:SF3">
        <property type="entry name" value="DUF2804 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="DUF2804 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="333" mass="37014" checksum="C264991A9F39B216" modified="2012-11-28" version="1">MIEKELTSPVVLTTAEGKFNKAAHGWARQPIVDTTGIDGTTFTGKNRRWEYWLVMTPTHLLAFSIANIDYFAPASVWIFDRRTQKVVEAAARAKEEDAVKLPSNVEDGPASADIGDIHVNIDQVPGGTRIRASIPGASFDVMAHMPEGHERLAVVVPWDDVLFQYTVKDISRPAEGTVTIGDETFPVPKGESWAMLDHGRGRWPSNVHWNWGAGSGKDTKGRTIGLQVGDKWTDGTGSTENSFLLGTKVFKISEKLTWDYSMEDPMKPWHVHGAGLDAVLTPYYDKASAYETPEVTTRTDQCFGYWKGTFDNGEEVIEFDNLDGFAEDVTKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAL8</accession>
    <name>K1VAL8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAL8"/>
    <dbReference type="FunCoup" id="K1VAL8">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAL8"/>
    <dbReference type="eggNOG" id="KOG2854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045832_1_0_1"/>
    <dbReference type="InParanoid" id="K1VAL8"/>
    <dbReference type="OMA" id="RTMCTYL"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="47"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC97830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="377" mass="39354" checksum="8EE0280B854B61FC" modified="2012-11-28" version="1">MASPSVVCIGNPLAAVQKLPLSTASVLWLQANVQLDIQVSAAQGPAYLEKYGLKSNDAILAEEKHMPIYEDIVANADVTYVAGGAAQNAARGASYVLPPKSVAYIGSVGDDDLTQTLSKVNETEGVISAYQIQPAPAKTGACAVILSNHDRSLVTTLRAAEMFTPDHLKKPEVAALIDGAQYFYIGGFFLTHGVESALEIAKAASSKGKTVVLNLSAPFIPQFFKVQLEQLLPHVDILIGNESEAAAYAEAAGLGDAQLPQIASALAASPKSNPSRPRIVIITQGADSTLVASSQPSASPVNLSPEEENPKVFPVPKLADDKIVDTNGAGDMFAGGFLGAIAQGKTLNEAIEVGHKLGQMCCGQIGPKLEFPKVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB88</accession>
    <name>K1VB88_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB88"/>
    <dbReference type="FunCoup" id="K1VB88">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VB88"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="InParanoid" id="K1VB88"/>
    <dbReference type="OMA" id="CSDIFFE"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="259" mass="28976" checksum="7780979CDFBDF922" modified="2012-11-28" version="1">MRPTELTSDIAVNLGDPMFRGQYHGKRKHEDDLAAVVQRAHDNGVERMLLTGTSLEESKLVLDLAKEFDYDRLKFSDKETQLKHLPRLLQLSKKYNLPMFLHDRHPEAHADLVRLLKEAGFDSTWPGGVVHSFTGTVEEMQQLLDMGLYIGVNGCSLKTEENLQVVKAIPLDRLMLETDAPWCSITTTHASHKYVPKTLPVEKVKPEKFQEGKGAKGRQEPSDVVVVASVVAGVKGESVEAVAQAAFDNSMKVFWPDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC74</accession>
    <name>K1VC74_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC74"/>
    <dbReference type="eggNOG" id="ENOG502SH1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1066293_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC74"/>
    <dbReference type="OrthoDB" id="2537258at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="261" mass="29870" checksum="DB416C03284EDB3C" modified="2012-11-28" version="1">MSATEPRHRPHPAPTYSSSSSRAHPYAGHSNGHHHHHRRRSPPPSILTEEFPPSPPRSRHDQSQSPTAMKPQDDGFENLPPPPASLKSILDSFRRSGEGDRDLLMSILGAKKAEEERMTAIIQTRLTILQARLNLATIQAQMQAMPPPDAMRAERTPSLTHSASSHESSPAYYDHVHLPRPMGYGRERDERLPPMDERDMMEYAKERELREIREMREARERELQQFPDKMMRARSDSSSRPQQGLEMLLEGVREAERKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCK8</accession>
    <name>K1VCK8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCK8"/>
    <dbReference type="STRING" id="1220162.K1VCK8"/>
    <dbReference type="eggNOG" id="ENOG502S442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090376_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCK8"/>
    <dbReference type="OMA" id="QIDERMQ"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="30852" checksum="46FB455CA2F19F8E" modified="2012-11-28" version="1">MSHSHGGGCCDHDHGPQTTGMGGPPGGGGGGPPQMNIQIDERMQLLLDSLPTRNVPFTLVDVPLPGSQPPQTQQMVVCAEHKAPVCETCSVNFTPLNYMHQFMRSAPPEAIPPPPQVQPPPHRAEAIKQAKEAGNGNIPGAIQNYSRSADMALSRPPWELAAISRDETAIALCNRSAAFAAAGAFTNALADADAVIALKRPWTKGHFRRARALAGMGRLEEARQAIVDGLQFEPDEKELNDVLREIDHQIEMVENGTFEPEVAVKEEQVKTEAKPAVKEEVKEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCW1</accession>
    <name>K1VCW1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCW1"/>
    <dbReference type="HOGENOM" id="CLU_731947_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCW1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="378" mass="42605" checksum="5AA70C06B1631E35" modified="2012-11-28" version="1">MSSTSSWSLKSWISGRSSIRTSRSNRSLASNLSVSSWGNSAISVHSQTTTYAQSSSSDSTITARSRVGSFALSTSSTDTERPASPTSTSNPGPTPPLNHPRSHNRYNALTRAHVAAVAELDAIASTLLFGFSAVHKHAESELRAAAAWVMLEIIEAHFESTNELATQRYDRICFWEPENSELRSWAGAMEARYALKMPDQLRDTKLALLSDALGTRFGEFPEVGEMRARGRNTNPAVRHMIFAMLVTELRRQPEASVPELYETMSLWARGEVLLTLTDEWDVDSVRGELSAIFDTSVEYCDQEAEGSREDRKSRTHPKDRKEKRKPKLSAPKEKYEESQYESKFESEYERRARELGLCPEEMMAMERFVRELEEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE13</accession>
    <name>K1VE13_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE13"/>
    <dbReference type="HOGENOM" id="CLU_485009_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE13"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="562" mass="61533" checksum="623DE5A8C8445E6D" modified="2012-11-28" version="1">MSPIRGHLLLLGITSAVCAGSFVLNFLYVRQGSKGATRPPRSGLNGRGTSGHRRKFGGGGGNERLEGKNRALTSAEAVAKALQVDWWHDGRASLGIKGQTFWAIACAGYCDLLLGFDLIFPTAAVLHVWFELLVLLLMAGSGITFGVLAGLSDLQHLFRGLDHDKTFCLLGLLGVLIAYVGAILALITACFVWRVPRRIVQSSDGKKYWRRSIRQIYHNRYTGLPPDVIFADLGDSTKRESSKGGESWYQESAYALNTQQRTSWIPPDHGQAPPYVPPNPYSTPYDRHVPSAFQRGVSPSVPTSHHLTLASTTDHGRDISTPHPLAPVKRRTPPTHPATHPRHSLNALFTNQPQTYTMGHPRITYIVYTVNCLLIILALAFAMAFYTTGLKNSLDVYDRLHAEREKEQGPYPLDYSVADSPLGSCSATPPSAAQMDALRPPPPRRVGAGRQLELGDSGGPRLLPLRHALPRAGEYEAVHAREGDVGDGLDQYCLSDNQHFSTAVYVYISQIRNDWAESPPAWQGWSAKQHVHSHNVSQAAPLGFASQGQVESIELKSVLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEB8</accession>
    <name>K1VEB8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEB8"/>
    <dbReference type="STRING" id="1220162.K1VEB8"/>
    <dbReference type="eggNOG" id="KOG2447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051361_1_0_1"/>
    <dbReference type="InParanoid" id="K1VEB8"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044297525" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="265" mass="28227" checksum="1E7E7DBC826F9627" modified="2012-11-28" version="1">MVRLGRALVLAAACLPLASALGIKGPKVLVQGGKDEQFSAKDASKPLFDTLEIGPADTFKLTFGVTGGPALQASAWYTGSEQVPVVQSLSVKSEGKKATLTIRGSEPPVHGENELTILLSNGVEEKPISWKVGKIILASASKKEINSLLSFEPLPEIAHTFQREAKIVMFPFAIAGVAAVLAPWALLLGLIGNLSSSLSKRTPPPSVYVFLACLVGLEALIIGYWVSWKLYQFLPPFLILSGITAYVCAVAMRQSRAQRIQTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEG4</accession>
    <name>K1VEG4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_08248</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000411">
        <property type="protein sequence ID" value="EKC97441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEG4"/>
    <dbReference type="STRING" id="1220162.K1VEG4"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="K1VEG4"/>
    <dbReference type="OMA" id="ESIRMTP"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC97441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="567" mass="61683" checksum="59A85C1304F0A525" modified="2012-11-28" version="1">MTKETAHDAKGVVEMQNSHTAELERKRLALAGPAGVAGLFRNPRLLAISVVTMLGGLNYGYEQGAYGQCLVMAAFNTMPAFQRIIHDSNFQGISVAILGLGGWFGSLINGYCIDRFSRRWCMLAGAFICMVGGIITAAAYNSGMIFAGRFLIGVAVGSLSTAVPTYNSEISPAEVRGAMGGTWQLSVTFGIMISFWIAYGCHFISDTNTVSWRLPLAIQCVPAILLGIGTLFIPYSPRWLLKHGRDEEALRSLAWLRRASPDDELVRLEFLEIKAEAIFEQESVAEKWPQYANKPFLLQFAQIKTLFSTWPMFKRTAIGTLMMFFQQMSGIDAIVFYAPIIFKTLGLKGNSVSLLASGVVGIAMFVATVPAIILMDKIGRRPLLIVGGLGMAACLAVVAGITGGFKGHLAEHEAGAWTSAAFVWIYIACFGFSWGPVSWTVISEIFPLSVRAPGTALSASANWMVNFCVSWFLPPMLDAIDYGTYIFFLALCLMGVGYAMFLLPETRNVSLEAMDLLFGASDASRDEARMASIMNRLAAEYNGSADHHSNSSYMSDKPQGEKLESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEK4</accession>
    <name>K1VEK4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEK4"/>
    <dbReference type="FunCoup" id="K1VEK4">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEK4"/>
    <dbReference type="eggNOG" id="ENOG502QRN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEK4"/>
    <dbReference type="OMA" id="TYNDVHN"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000050">
        <property type="entry name" value="Related to XPT1-xanthine phosphoribosyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="211" mass="23828" checksum="A01D4CDADFC81A71" modified="2012-11-28" version="1">MAPPMLRLSYNDIHNAIAATAPKIKEQFSPDLFIAIGGGGFIPARILRTFCKNIENGTKRNIPIQAVGLYLYESMGGEVAGAEVTRVQWIDFSTLGNKLNHGGLLGRRMLIVDEVDDSRTTLMYTVNELKKDIDEQLSKVQDEKEREKLRAETKLAIFVVHNKLKPKVGEIPEDVQYFSAVDTPDVWLAYPWECETDIDEHDALRKDNPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEN2</accession>
    <name>K1VEN2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEN2"/>
    <dbReference type="STRING" id="1220162.K1VEN2"/>
    <dbReference type="eggNOG" id="KOG1462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016743_3_0_1"/>
    <dbReference type="InParanoid" id="K1VEN2"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="10">
        <location>
            <begin position="343"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="446" mass="49342" checksum="22AD6B6D6F65B849" modified="2012-11-28" version="1">MPVGNVPIVNIVLDWVFDAGLTDVLILVPPESEAAISEHLQLEYSSNNKLHITLKNYTDGEDDEDEEDNEKIGTARLLKQFRSYIKPTESVKDSEEKLLVATDKETDELLLIEPLETLEEDFSVRMSLLESHPSLSLSTRLLDAHVYVFRRTVLDLLATRRGRDLSSVREQFVPWLVKGAWQEGLGHRWAPSECRALLRSTATSYKQARAIEELSAPSSVLSDHTPLPSGITDGEELADFKANVTRGGKSARRRREPIPFTCRVIIHRPEVPEVPEKGKKSTAPEPEYIIRANSLPGYWEVNRRVVRNLAAQHAAAQAGNSKGVHSTPLSHQPQQPSGPADEISASAQISPDSLVGEGSRVGDRASIKKCIVGRHCNIGRGAKLTNCVLWDWVTVEENARLENVILCPHVRIGEKANIKDCEFGPGFEAKPGDTIKGERLIAGQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFC9</accession>
    <name>K1VFC9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFC9"/>
    <dbReference type="STRING" id="1220162.K1VFC9"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010840_2_1_1"/>
    <dbReference type="InParanoid" id="K1VFC9"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="488" mass="53656" checksum="E4029F4597FC7752" modified="2012-11-28" version="1">MNVSDPRELTRVEDFSGWSSSELSTPLQKSRTLNESQSPARSSSLTSLSDIDGLEHALGDLKTWVQEDTKLSELAESLPAEILAQVRVSWVRANVEILQHVSPKDLVSAMLVSKSWCFAAFHLLWQKPALSSITQFADFVRVITSPSPLLPYALTVRRLSFNGFSKHLSDRLFRDIVACKNLERVTMPGATNLSSSALCEVFANLEELVAIDLSGVTAVDDSVVSTIAAKCRRVQGLNLSRCNKVGDEGLLAIARNLRMLRRNLAQNAVPDLDLAAAADEDGLYDIIGAYPWYFLDVPSPKAMWRTSSRPKGVSLGQIRPFCKSFEQLRVVDLTSCLGLGDDSVEHLVNNAPQLRNLTLAKCSNLTDASIDSITRLGKHLHHLHLGHVSNVHHEEILTADCSLLGDVSVVALATYLPKLRRIGLVKSLAQRSATLERVHLSYCEKITVPAVAYLLNRLPHLTHLSVTGIAAFRTPELQQFCRTAPEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFJ1</accession>
    <name>K1VFJ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFJ1"/>
    <dbReference type="FunCoup" id="K1VFJ1">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFJ1"/>
    <dbReference type="eggNOG" id="KOG3471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027280_4_0_1"/>
    <dbReference type="InParanoid" id="K1VFJ1"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="11">
        <location>
            <begin position="371"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="451" mass="51756" checksum="A194B474F4529E53" modified="2012-11-28" version="1">MVQPSFSSSDAANGDSTVSPTAPLDAFLDNQPQTFYESIYRAEEVIRAARDRQIFQPLVFKHQKFQWSLNDTFKRGMRNALTGLGTSNSFGVPYKRQARDPAPTAEELIDYGENTWESILKYMVSSGLGARVTGRPRNSVLSLLHASGLMVDQFDDTGRNPNYDRLTITSQGFQFLLEDRQTQLWQILMFYLARKQRRGEAAADILSLFFSLGCMQLGQDYSASKSFQNFPQGQQCLDDLEQYGFIYRRQEVDGRKTDQFFPTHLATSLCSGDTSVNRSATADDKRFLILETNYRVYAYTSNELEIAILNLFVNITIRYPNLIVGHLDRRHVKAAMDKGISAYQIISYLTTHAHPQMYNHPPPLLHPSVTDQLHLWDRERNRVQAQDTVMFEFYSKELFETCRDEAERMGALQHSVQRGQGMAKLIFVDPTIRESLRDFIKEKKQQLRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFM8</accession>
    <name>K1VFM8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02844</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFM8"/>
    <dbReference type="FunCoup" id="K1VFM8">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFM8"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_1_1"/>
    <dbReference type="InParanoid" id="K1VFM8"/>
    <dbReference type="OMA" id="QERMVWH"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="551" mass="62348" checksum="9A7DF311EF4DA01A" modified="2012-11-28" version="1">MEAYRKEAEIPSQECVYTSSNGAQQPHPYYAQRAGSGGGLLLQDYHLIDLLAHFDRERVPERVVHAKGAGAHGEFECTNGLEDLCIAGIFKKGAKCSVSCRMSTVGGESGTSDNLRDPRGFSIKFRTDEGNWDLVGNNTPIFFIRDPAKFPHFIHTQKRNPQTHKHHTDDATLYWDYLSQNPECIHQIVYMFGDRGIPYGARFMNSYFGHTVKLINDKQEWVYAQFHMLSDQGEKNQTDPDQAAKESDDLMQNDLFESIEKGDYPTWTLKVQIMTKEQAREAWKKKGINVFDLTHIWPHKDYPLREIGKMTLNKNVDNYFAEVEQISFSPAHMVPGIEPSEDPVLQSRLFSYDDTARHRIGANFMQLPVNQPTPKYKHGNFQRDGPMAYFNQGARSNYLSSIDPIQCRPRAVNLDKAHGDFVAEAISWLSILRKEDFNQPGALWRDVFNDEQKSRYVDNVVGHWSTIKDKSIISRMISIFRAVDPDLGARLEKASGVQGGPDISQITFNGSHNGMAEPVKGANSMEYAKEFGLYQSGSVTDNPPAILPEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFU3</accession>
    <name>K1VFU3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFU3"/>
    <dbReference type="eggNOG" id="ENOG502TKVJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113432_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFU3"/>
    <dbReference type="OMA" id="QITSHFR"/>
    <dbReference type="OrthoDB" id="2563070at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="167" mass="18661" checksum="8E43D950353012C1" modified="2012-11-28" version="1">MAPRKRTTAATKQKDTADEQEREIVALRRENEANKQSSRNMLDLLVAVCFFICLSQIRRYMAQPSGPLLPLSIAQAVLVPLSLSPKWLPFLQGRGWANHPLVAAAHLILFFAMLVLGKTPETPLPETLRWAVPELVAGAVELQRRSEVQAEAALERLERLKYPLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG28</accession>
    <name>K1VG28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CORD and CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG28"/>
    <dbReference type="STRING" id="1220162.K1VG28"/>
    <dbReference type="eggNOG" id="KOG1667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040079_1_0_1"/>
    <dbReference type="InParanoid" id="K1VG28"/>
    <dbReference type="OMA" id="KGYTCCK"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="229"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="38992" checksum="CC5F829A958FEA26" modified="2012-11-28" version="1">MARCTHKGCGKEFDPESNPDGDCTYHPGGPVFHEGLKSWSCCNEKNKPVMEFDQFIAIPGCTKGKHTDEVPKAAPAPKKEEVEAPTEKKGGVETYGSAPATAPASGTGTPAPEEPANQTPAVTVATQKQPEPEPQVEEEDDPDIPVPDGAHCKHLGCNAVWKGQDISRGDGPEAVCTYHPQKPIFHEGSKGYLCCKRRVLEFDDFLKIPGCTKGKHLFVGPKPSGKEELVEARVDHYQTPTEVFVSVYAKGVDKATSKVTFGPQSIDLDLHLPGNKRVKRTLTLYGPIVPEKCSYRILGTKVDIELTKPQPASWPLLELPPPGTELPPGYAITFGVSGRTGTVGGKEIVLSAEEQAKHAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGG9</accession>
    <name>K1VGG9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000265">
        <property type="protein sequence ID" value="EKD03190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGG9"/>
    <dbReference type="HOGENOM" id="CLU_1327221_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGG9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="22740" checksum="0EB4FC3B9A19207F" modified="2012-11-28" version="1">MTHWVSPPTPRSKANAIAAGVIGAVVGAGVLFVVVLHLVRRRKRRQAQATARHRREQQLQVLHASRHRPHLVPTFEPTEDVQVITPYPAPSRPSPSSRSSTDRISRSKTAKPRGPRDRQGTTKTPIVAKKQSSALSEEPRRPQANAPGIVNNSEAATSGRHRAEDMEDAPENELLPPEYKEEWGQRHSAALEEARVVDPLGKGGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGV7</accession>
    <name>K1VGV7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_07335</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGV7"/>
    <dbReference type="FunCoup" id="K1VGV7">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGV7"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_5_2_1"/>
    <dbReference type="InParanoid" id="K1VGV7"/>
    <dbReference type="OMA" id="KMAFITC"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="66"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="244"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="644"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC98321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="690" mass="76571" checksum="A0CA480D185DF9B1" modified="2012-11-28" version="1">MSAETFHADWIAKGEASSTTPSKAKAKSKSSQSSWQALGVAPSLVRALQLRGFKTPTPIQRASIPLTISNPPRDVLGMARTGSGKTLAYLIPLLHRLGFRREGAGIRALIMCPSRELAVQILKAGKDLSRNLATGVSDAQPLRWSLVMGGESLDAQFESIVSRPDILFEMGFEQQLHEILHRLPVNRHSLLFSATLPSSLAEFAKAGLNNPEFVRLDSDMRINPDLDLGFFHVKPDEKDAGLLLLLRDVLKIPSRAASIDADRAKAIIFASTKHHVEYLSVLLQAAGYRVSYIYGSLDQVARQQQLKRFRAAETDLLVVTDVAARGIDIPSIPHVINYDFPTGVRVFVHRVGRTARAGQHGHAWTLVTRDDLPYMRDLEIFLERDFLKDKESYGNLPRDSLETMLEYVQQTLDIEESQLPSLREVMRRGQTMFERSRAKANKDAYKYVKEISASGGPSLVHPVFSSNEAPSDLQAAGRDKLLASIEAYQPHETIFEIGARGKQAAAQLMKQRRDTIARRRSQRASAPDDNAMDLDDSDIDTEKPLPRAIAILISIYLRSGWKRTEREGTTFAEQARSATLDLNADEGDAARAQKASQLKWDRKRKRFVKDAPGGDNKKMIRSESGALLPATFKSGKFADWKKSRRSRADHALGSEAQSGGLATAHSIVKERRIKEKVRPLSNTPTNSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHM0</accession>
    <name>K1VHM0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHM0"/>
    <dbReference type="FunCoup" id="K1VHM0">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHM0"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="InParanoid" id="K1VHM0"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="135"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="458" mass="50470" checksum="EC925E654AB3BFC3" modified="2012-11-28" version="1">MAPVAVPKVEDLSLEDREKQEAAADAAPAQAEPKPDENGDEHDSDDDEEAEGEGGEGASGAAKKKKKKKKPKKKKTAAVQSDPPRVGLTKIFRSGVFPVGEEVEYKNDTTSRITSEEMREKERLAQGDPSTNYQNIRRAAEVHRQVRQYARKHIRPGMKLIDIANMIEDGTRALVEEDGFESGIGFPTGLSINECAAHYTPNPGDTKELKQGDIIKVDFGVHVKGRIVDSAFTLNFADPEWDTLLQAVNEATKTGVAEAGIDVRLCDIGEAIQEVMESYEVEIGGKTLPVKSIRNLNGHSITPYVIHGGTATSHGKSVPIVKQFGEHKDTTRMEEGEYFAIETFGSTGRGKVYEDGVCSHYALSPQMPEHYTLRHQSAKNLLKSINKNFGTLPWCRRYLEHVGEKNYLLGLNELVRQGVVADYPPLVDPEPGCMTAQSEHTILLRPTCKEIVSKGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHP5</accession>
    <name>K1VHP5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHP5"/>
    <dbReference type="HOGENOM" id="CLU_1289755_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHP5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="214" mass="23662" checksum="C1F3D9EDA3AA72EF" modified="2012-11-28" version="1">MDCAHLNKAQAAPRNSACSERRFEGCKGLFNLAGQDDRTGKRRNVADGRGHCHTRKRHTASRCGHLRKCGVRHLYPEVGEGEGGRDPVIWRFAIEREDWIRRGCRKAGGYHTLYALTPFTVPFLIEFDHARVTRVIELFKKRRQRGTGRCKEAGEYIIHWPLEQAFVEFTAERTGTGTDQGAAEGNLVSTSRAGDSGAEVAAKAAAAEHGCLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHR5</accession>
    <name>K1VHR5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHR5"/>
    <dbReference type="FunCoup" id="K1VHR5">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHR5"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHR5"/>
    <dbReference type="OMA" id="GRVRHCA"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37377" checksum="0AD763A014739C9A" modified="2012-11-28" version="1">MSRDTPNAEAKPKYDLGTYGGRLAYFYSTTSPLTLLASGQQLDDAVAYARGWDAKIKAAGKDGVWVDADTRDKYDKAKQLVNSSIHPDTGKPVPLPFRMSAFVPTNLLICAGMLKPNPSLGSIIFWQWANQTLNTSFGSANAQVAVNFSNANKSIEMSPQEIGTAYVAATVTSVGLAVGLTRLVPRLRVSAAAKNILSKLVPFAAVASAGVVNISCIRWKEMRDGVDVFQIATDARGDETKTDLGKSPRAGQMAVMQSAASRVLTNIPTLIIPPMVMTYLQHRGAFVGPRGHTLSNLTQLTLIGLSLGLFLPPAIAYFPQRASVSTDKLEPQFHKYHEKVYFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJA7</accession>
    <name>K1VJA7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJA7"/>
    <dbReference type="STRING" id="1220162.K1VJA7"/>
    <dbReference type="eggNOG" id="KOG4051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1134243_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJA7"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="248" mass="27611" checksum="D7693E1284302E8C" modified="2012-11-28" version="1">MEDDQGYQHEATPVVSDLELIEAKDALRQMMSGFGLTLCARGLRKDRGMFNQAVPARHTDQTQVHEQTGVWVPITRLWDTLGDLYNLDALDNMSSSTPSLPSSPDQLSPIPLRHRRPKRSASLSSLSSSPPSPTDGPSESKSAKVINSAHFGRAFELPPLRRDSGDEGEGPDSDDLEWHDLLYSRATGGDENEDEWKERIERQMRENGTESGSPTPEDKPKKGKRRRGRESTDGTPPAAKRGRGRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJH2</accession>
    <name>K1VJH2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FIST domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJH2"/>
    <dbReference type="eggNOG" id="ENOG502S59R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051231_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJH2"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="44846" checksum="1B9FD7979A3436D4" modified="2012-11-28" version="1">MLSRTIRAAQRRLGGSSRRSLTVKANTLVYPTPEAVESWLATVKKDSVLLYSLSANLGGWQGYLPMVQGYESVGSFHHSTLPSLSLAAFERDVLSEASAFYTPLTGRGHAEVGRWHRVGTDWGADKSGSEVGSLEALIAQKGWNGVWDGSGVAQGSSPSTAPSKPGEVSGGSRDELNVDAETSAVLCLTDANPGPVLARLSQRLIRTVGLVSAPTPFVTGSAHTLWCNKERYEKGTVGVQLRSRPQVAVRYGTQALGAPMMVDSARGNLLLSFKGASSNPTQTLINLLQERDHGKPRTGLEKDEDFWLEISDPHSDAIRVVRILSGDPSRGALSLDTDIPLNEGQMVQFQQRSDKAAEPQAPLAGATIRFGALEKKDTYEAPPPEMGEGQTKGFLACSEEGFVLGRDVCTVPGAAVTCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJJ3</accession>
    <name>K1VJJ3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJJ3"/>
    <dbReference type="STRING" id="1220162.K1VJJ3"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634898_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJJ3"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="4">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="432" mass="47428" checksum="20F08CA3D9869488" modified="2012-11-28" version="1">MTSSFELADIHRILTVIDLDDDEPFAAGEDNASGVGHDAADDNASGVSHDAGDDNSSGADIDAGAGNAANLEDAENGIAGGEEGGEAGEGTMDVKTAFLYGELDEDVYMEPPEGCEVPSKMLWKLRRSLYGLKQAPRACSCTSYLSAPQRKFSTKLSTACHFGTTGSLTQLHSSTTHTRDNQNEHFLVIVDNLMNLDFLFDVSEWTGDNKYRDMAISQADKMQTAHVRPDGTTWHVVNFGHDGQVLERMTHQGYSDDSCWSRGQAWAIYGYAQMSHRTGRKDFLATTRKVADAFLSRLESSGLPAWDFDAPRNPLVYDTSAATITASGLLILYRVLRDHDPQAADHYLSSAFDLIDSVNRECRAPPAKLEDGKVNWGEGGWEPILMHSTINGNEHAEEPSMDTGLVYADYYYAEFGNEAIKLRDELKKTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKE6</accession>
    <name>K1VKE6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_06060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKE6"/>
    <dbReference type="FunCoup" id="K1VKE6">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKE6"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKE6"/>
    <dbReference type="OMA" id="WKRPTLD"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000077">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="455"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9 10">
        <location>
            <position position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC99641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="788" mass="88701" checksum="4F249DDBE0A0CDBE" modified="2012-11-28" version="1">MKRTLNPYWNENFDITVKDSSVVVVQIFDQRKFKRRDQGFLGVINIKVSDVLDLELGGQEMLTKDLKKGSDNTPVNGKLIVYLSTQTSTPITNPGPTPSARPAAINTGGESSTNSLNANNTSTPEPDSPATHNPRDSFATGGSTTSNPTTATTTTPSTTAINTNSTATMNSQQPSQTSPVAPSQNHQQSAISAVAGGAGSAGNTQFDSHSDQLGPLPHGWERRIDHLGRQYYVDHNTRTTTWSRPSSDQQSNTNNAANSTGVARAHHNTRLTAEDMLGANTTGGSQTPNQGQPTTIGSTNQATTVGSGPLPAGWEQRFTPEGRPYFVDHNTRTTTWVDPRRQQLLRVMAPNQPGVTVQQQSVTTLGPLPSGWEMRLTSTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPALRSNTGQCHVKVSRNNIFEGSYTEIMRQTPNDLKKRLMIKFEGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPNSGVNPEHLNYFKFIGRVVGLGIFHRRFLDAYFIVAFYKMILKKRISLADLESVDASLHRSLTWMLENDITDIIEETFSITEEHFGEMVTVDLKENGQNIEVNEDNKKEYVDLVTEYRISRRVSQQFESFMSGFNEIIPQELINVFDERELELLIGGMSEIDVDDWQKHTDYRGYNPSDEVIEWFWKIVRSWPAERKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEITQLPKSHTCFNRIDLPAYKTYESLEQKLTIAVDETEGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLV5</accession>
    <name>K1VLV5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium/proton exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VLV5">
        <property type="interactions" value="77"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM78</accession>
    <name>K1VM78_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
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        <property type="protein sequence ID" value="EKD05245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="(Trans)glycosidases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="486" mass="50730" checksum="441A7FC02752D84E" modified="2012-11-28" version="1">MPSGGFPEPDSYIDPLSSKDNCTRDLPHLQELGVNAVRVYSVDPSKNHDDCMKLFDDNGIYVLLDLSLPANGSINRAAPSWTTALLDEYMRTIDVFNKYDNVLAYSVGNEVVSRAVNTDAAPFVKAAARDIKAYLRSIGSNAMVSYSAVDGDSNFRGGVAEYLTCGNDSVTIDLYGLNNYAWCGSSSVTASTWSNMVDDFKNVPVATYMSEYGCIEVKPRLWQEVDALYGDTTVTDVFSGGVAFSYFPTSDGYGMVEFGGDGKDVTVSTDFTNLAQHLKNVTTAKTPAQSAAQTGSIECPADGAKINASSKLPPTLTRPPTANDPAKMGALTDYACSLLGQANTSVTCENISGNGSTGVYGSLSFCSPEVKLNYAMSSFWETDQKATSCDFGGNATLTPNTPNTQASSEVAAKCLANASAVTTPSATQGGPSQTTGVAPTAVVSGGKDAGSDGGDKKDDNKNSGANAVFASLSMVVLAVAGAVIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMH0</accession>
    <name>K1VMH0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMH0"/>
    <dbReference type="eggNOG" id="ENOG502SBXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112572_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMH0"/>
    <dbReference type="OMA" id="KGPQAWE"/>
    <dbReference type="OrthoDB" id="2224399at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="227" mass="24931" checksum="0EE86A6E7101B21B" modified="2012-11-28" version="1">MLAVADLQPLLGLKPDEETLKLALSALFPGRSLVADTKSYPDAVYQNYYSLGISLCFEPDASKVMRCVTVDVFNSPTPGSSTSAGGRPPKGPTYDETSLPLVFEFAEKEIVLPPRQEGEKEMRLPRDPRVEVRKNTTGREIVRSLGEPSRKGSGSWVGVWLEWNSVGLLRAGERVDVGVMLELNDPKGADQMSQEQMKQGMGGLWDMAAGWRWGGIKVFKAEPKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMM7</accession>
    <name>K1VMM7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-4 methylsterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMM7"/>
    <dbReference type="STRING" id="1220162.K1VMM7"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_1_2_1"/>
    <dbReference type="InParanoid" id="K1VMM7"/>
    <dbReference type="OMA" id="DFHHFAF"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="183"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="38838" checksum="1E0D9C60BF691718" modified="2012-11-28" version="1">MLAIDDVAESPIQGQLGNDSNGAANGKDEVYKGKNHPWAVNPATRLNHDTLINLIPTFGMILLTIAVNKSQWGQDFYRWLNANYTPFEINTWWIFGITTVQYWITGLIFCAFDMNDTLHNMVARFKIQPQRRITWAEYRQVFYVVAKNQLLMALPLSAASAYIAPRPTGLPLPGAWTTTWTYFVCLFFEEAGFFLVHRAVHSKRWYASVHKMHHQFQAPVAMASTYCTLTEHLFSNLLPIIAGLWLCDAHWSLAVMFFTSLQIGTLCTHSDYNIPGLYDALQHDWHHYSFTENFGPTGLFDRICGTDKNFKIWLKELKRRDAAGWKMNGRTELVDKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMT5</accession>
    <name>K1VMT5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAA35-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000335">
        <property type="protein sequence ID" value="EKD00672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMT5"/>
    <dbReference type="STRING" id="1220162.K1VMT5"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375608_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMT5"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="2">
        <location>
            <begin position="191"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="739" mass="81317" checksum="2D2EFB39377308C8" modified="2012-11-28" version="1">MSGGVARATGPGGVLAASDAEGRLREIGMRKRKELCAKAVDGDQSKGGDEVRHAPRTSEHLAAGVEEATQRDFAHRAQQVLGLTSGLGPFRATRSSSAPKPSPSSPAAIAAGYGRPWELGRASCRVTQRIKLGPRILRTKSRRLNLPFLPEGVAQLLSFLLESIADLDAVATPTMVDIKDWLQNAASSLDPGQVIKPDSLTYLEAMNALEMMDPAMDWGVNFNPHGEFDPHAALSPVQVCWIMDEMAAREVAWLRGGTVAQTFLTSLHYHNPLSLQPNVPVSDPSFYQAEASCAALRAFVLAYAKGIEVAYYAVLDSGAVRDGEDTWLDTYGVPLETTESIDDVRAYVSSCARWLLSGDHGPEWDANAWVQVVNRLNFQLTWMDTLSLKVARRPGPIHLAPESAKVDWAFDNVAPFLRQNMPLPTLTMPGHAETWATFARAMEDMEYARALSKLDLREREMALLRGRGEMLPVVRALWKVLLVDNHPVNEMMDEWLDDIGAEDVMPTIDAAIAKEDRWSFSYIRDITGGNPARTRRAYEHYARTWTEQAAAATRLTRKCPAAAPLIKILQARALDCQLNASLLAFDLGLVGHDERRMMWWWVAKVAGARSVLDDAWQARWAAAWLSIASAMVLQGFRAKEPVHAPAQAGAPGRLTEAVMGGLGGRTESPRQSDTLERAEEWLVDGEEKLGEVESRTLRTTSLRQVAHANAALLAQGIPLVWDEETRYSIPKLKPAQTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMV0</accession>
    <name>K1VMV0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07583</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMV0"/>
    <dbReference type="FunCoup" id="K1VMV0">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMV0"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049363_2_0_1"/>
    <dbReference type="InParanoid" id="K1VMV0"/>
    <dbReference type="OMA" id="MIVLSQH"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="299" mass="31572" checksum="099119C551695DAF" modified="2012-11-28" version="1">MDADPLYHVKQLFHQALTPACIDEASTQPLTPGSEEPALQRAIYVARSYLALRPPQVDAALNVLAPFTSLEVPPTPARAAEALAKYIQTGSEDVVENVRDIVLEVEGEDSVDEGLVRALAGTVFILAGEKEEAVATLNDGAGHDDLECLALLTQLLLSLDRRDLAQSTFAHAKAIGNDSALVQAIEAWIGLKTGARPLHQAYYYYEELYQLPGGRTPGVLAAHAAAHLLLGHEDEAKADIADAQGQDPNNEDVLAVATALGDNVAAAKLANTKHPLAADLASKSALFDEAAAKFVSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN02</accession>
    <name>K1VN02_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000080">
        <property type="protein sequence ID" value="EKD05570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN02"/>
    <dbReference type="HOGENOM" id="CLU_912732_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN02"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="305" mass="33576" checksum="DD00F24AB9E20E6D" modified="2012-11-28" version="1">MKRRASTISTSGDSSASAVDDLPISTDPTLVATETVTLEVEEEEPFDPPPELVSAYESLMKERVDLADITPIPAPDVSSTSVAAVGPVTPATAATTDADADAAAEAALGRPMTKAEKQNAKKKRRKERERAMKAALEAAAKPEAPPLPKNDIVLRFELTSGFPLFAAPVDVNLDDTEYYEVTRNPRLTPLPAEARERIARLATEAEWAHEHYPSLPPARSEQHKIYTKAKELPRSFVAHFPESKLAKGHGWSHINVFLPPVAEPEEEEMSKSKRRKIRRQNAAWRETVVGDLYRSGKANGYGWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN59</accession>
    <name>K1VN59_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN59"/>
    <dbReference type="HOGENOM" id="CLU_1455376_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN59"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="186" mass="20000" checksum="186819BC83CC5816" modified="2012-11-28" version="1">MPFRATPRARSPESIQLLRRSSPDPESGTAPVRPAGSAWASAALSAWLLWCGGLVMRGMRLHRLQEISQLAIAICGVIGHRIGHHMFKIAAAHRAGRWPTAQVWEWGCLYAETPLDPLPAATTTPAAVGPVAVTAQDDPSVTAPARTSADDEHVRSPLPSPEGDTEEDEGDTEEDEGDTEEEECHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNA1</accession>
    <name>K1VNA1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNA1"/>
    <dbReference type="HOGENOM" id="CLU_1476154_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNA1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851982" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="183" mass="20230" checksum="4F2F67D3C5F5D8CD" modified="2012-11-28" version="1">MLLSTLLTALSSAALTAAQLVPIGFQIQGSNYCMDVRDGVSEIGAVVQIWECHGGPYQRWVVEYPTRVLDPGDLMGESQFSRIRWAGSQVDMEHSGYCLGFKTKDDEPFATADPDSLWMTDLVLVDCARDGVGWYLHPQNKLCAYHHNGKDSYCMQLDGPANNGVKVLVVAPSWNEMAARWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNF8</accession>
    <name>K1VNF8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNF8"/>
    <dbReference type="FunCoup" id="K1VNF8">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNF8"/>
    <dbReference type="eggNOG" id="ENOG502QUUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_746366_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNF8"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="371" mass="39342" checksum="87FA8CB9CE5DAE30" modified="2012-11-28" version="1">MSSHAAESADWINVLGAQVLQGYRNDLLSSGGEEGARKQFERWLNPPGRELSWLDPIEVTSVNLGKAFPLLSNSRIRPADGEGRVRAEVDLDYADTVSLAISTAVLINFPRPRFAVLPVAIGVELVSFGGTLSVQIHDPKDEQQHMHVCLLPDFSLNLKTSSLLGSRAKLQDIPKIEQLLVERLRAVIQDRIVYPRHLTFALPRLLSRTAPEATSIVPSTTDLRSVAVHAMSQGISKLGQDLAGRVAALAPADSASVVGGVADAPTVDSAVDVESEPMSVPQSIPAPRRLPPTYSGNDGVQRRPAPGIVSAVSSNPASTRAGSGPLASVGTTSAVRAPLSSNVTNGDLRHRHADGESLDSGRRLGALNSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP50</accession>
    <name>K1VP50_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP50"/>
    <dbReference type="STRING" id="1220162.K1VP50"/>
    <dbReference type="eggNOG" id="ENOG502S50Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042568_2_0_1"/>
    <dbReference type="InParanoid" id="K1VP50"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853951" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="74"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="371" mass="40881" checksum="5503D53B6E3BE3A7" modified="2012-11-28" version="1">MTQLSLMFLVVLAWAAVANSWAGTNTYFLQGMFEGKDQIDFIKELASIGVKVFRLSVRYQVLGCDKGTKVTWPVPALELALGEYKDETLDLLDQTLNLIRQHGNGMKVIISPHDGNSLYGCVKVMTGSNARISSSDPYTHYGHSFYTSEEAENYYDNRIRHILDYRGKYTGEVWKDFHEMILAFDVQNEPYAGLRQACGSEVGSDIAAADWVCRRASFMRNSLLGAGNPIKIASGGLGGSDRNGCSFLEGAMQCPELDAVARPGSAQLASDIEHWKSLANGKLLLVEALAIQWRRSDLNVISEFKKATDILNSAGIPWLSSSIIPDPTRSCAKSFESDADLTFIPVTLAKVDFKSAMESATNAEAWQDWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR03</accession>
    <name>K1VR03_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR03"/>
    <dbReference type="STRING" id="1220162.K1VR03"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1166550_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR03"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="238" mass="25633" checksum="6CDE6BDF5303B647" modified="2012-11-28" version="1">MSENGTQQQQLPKEQQPKEQQSKDSKPHYPSSPLDNGTNIGSAFGRKASISGGQPFALERRPSTGSDRRSSNSSSRRPSFGAPLHGLTSMTAVDSPPASAALSRSPSGRSSRASSRRGSGTVVTATGQQVVFHTRTQRMRMIVTAFEDTLDLGLEKKGQVVPMIPTFVFGWPTGHEKGEFLAVDLGGTNLRVCLVTLEGEGKFEVTQTKYKLTEEQKQEDGQALSPTPAPKRRSTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRE4</accession>
    <name>K1VRE4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRE4"/>
    <dbReference type="STRING" id="1220162.K1VRE4"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639666_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRE4"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="436" mass="48645" checksum="300D3EED093153D8" modified="2012-11-28" version="1">MPGMDVEQGHHPPKTPFATTYRSTDYNTLSLPYTPLPYTHLSRNPSKVSLPPDYSPSTPRSPLLHRRTSDFSVSSRGSRRRKAPPIHYLPALIAVILFTVTVAAWSLSKVPCGIPHLCSESFSDVLARNTGTYAPFREQRYQSPPATCKLHRHTARYPTESAAKRLKKTLAKIAARQVKYPDHRELGFLPGANLDLEGWDMGELTDQGRWDRATTLRSAIPSNCSLAARIVAAFLRLGSTGFRDTTVSSLARTRRIVLMLSSRKARNNTLSVHNCRGFMSADPPFGTDEREALLPILKSAARRLNGILQPHPPLTPLDVVHLGHMCGYDSAAAPRWRGWSSWCNMLKRSEWEAVGHIADAERWYSVGEGSTMGAGYVNELLARLFDRAPEDSTTTNHTLNDNAETFPRGGHRLFVLDAFHEAQAWSTEHVNWAKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRL0</accession>
    <name>K1VRL0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRL0"/>
    <dbReference type="STRING" id="1220162.K1VRL0"/>
    <dbReference type="eggNOG" id="ENOG502S7WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1103421_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRL0"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="27097" checksum="6176499822F07C68" modified="2012-11-28" version="1">MNQFPANAIPGLQPPPGMVPGMMHPSMMQQLPPGMAPPPGMMPPGAPGGPGGPGGPCAPPEMLQQQYLHQQQLAMAQAMRQQQLQQQQHAVSVAAANAQAQAAQAPQARPKPRKGRPPVLPRGQQGDYVKGAMAPPTVPAVRQTEAGNAATGLETEPWADMLDELDPRELAMARFRARQEVMTEIFGPERVQDVPEPVTDPWSGIGITGETLEAKVEALEKSNAELEANFDAELEAWRKRLENPELIEPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRM5</accession>
    <name>K1VRM5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRM5"/>
    <dbReference type="STRING" id="1220162.K1VRM5"/>
    <dbReference type="eggNOG" id="KOG3841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_381390_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRM5"/>
    <dbReference type="OrthoDB" id="2562432at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="726" mass="78222" checksum="E6BB7C1F02C9CF1A" modified="2012-11-28" version="1">MPADAGPSVPSQAKQEQPGAGFICTPDQLYMHVVGSYPSQEAFGYPGDHDSHGQSPIARSRADDNEDAAGASARAKKRRKTQRRAKVSEIWFPKAEMAFCTSVACIPPNGRTKIKFFGRPLGRNELIAAICTLATRRLYNRKQISSHSQVLKDKVPPVFKEIFTFEDKSRVGEEPGETSTANVIENYSFPEAIYNIIGYRVGTDLANSPKPPWLLDLEAGVTDAPTSMTEAGGPRGAGAYSYWNSPSDYTSWTYDRGGGGSSHRKDPYYYGQHGGASRQQGPYGNQLHTLPPLSLPRDMDAQSPVTTSPSTIGDPLSGGRYPYGSMGSRSQYGDVGRSPPTSTSPYDSQSGASPFYPPHPGSEPSGPVTSAAAGGQNGHITLPPLPDNPPSQYSDWKDRSVYPETSKYAPASYGSQSSRSGLPPLSNLPSLGSVASQTSGYGLPLSSTSQPWGSSYGSNWSDQRSLPTFQPTAFEARGRAYDGSQVPLTINGPLAMGEPMAWHSIYMWRERYPFLEQIAATPGLSVFHIDVYFSLPADWGMQMSEMSVDLSLRPPGNETTGWSLVTDSSFLHPSGHVRYPRTATELRLNNSGDLVGSAPTSEMGRLYNYLLADQGRDIETLASIGSPNSAMVQAVMRDTSVSIPPHHVGLPPLGADWNLASTLIIYTFWSPDPDPSRQGLPPQCRPVEFAPPAPLPPVDIGSDPLVAGLLAGEDTQPSKFDWMGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRQ1</accession>
    <name>K1VRQ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRQ1"/>
    <dbReference type="STRING" id="1220162.K1VRQ1"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRQ1"/>
    <dbReference type="OMA" id="GMLQQDM"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013175403" description="Peptide hydrolase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="178"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="387" mass="43189" checksum="5B3837BDB30F6F9E" modified="2012-11-28" version="1">MHLATLLTLPLLAAAIPAPQAPAGDAQAVFGIENNNNAVSSDLNIDLNELRLVKFSEDEPPKWITELEKIEARARGRKFMDITDTPTLGLTSFLNEDKYEYPKPGKYKKDIKALYKNLSEDHMKQFLSKFTSFRTRYYKSQTGKESQKFLLSTIKEIARDEKEIDISEFEHPWGQNSIIVRFPHTGKKDAPRVVVGSHLDSTNMWPFLPAPGADDDGSGTTSSLEAFRALVHGNFTPSGPVEFHWYSAEEGGLLGSQAVAKSYEDKGVKVKAMLQMDMTAWVKTGTEEHVGLVHDFVSAPLTKFVWKTVETYLDIGVRETKCGYACSDHASFTKAGYPSAFAIESEFDLTNHNIHSTSDTIDHPEFSFSHMKEFSKLAIAFAYELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS54</accession>
    <name>K1VS54_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000288">
        <property type="protein sequence ID" value="EKD02372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS54"/>
    <dbReference type="STRING" id="1220162.K1VS54"/>
    <dbReference type="HOGENOM" id="CLU_1476153_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS54"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="183" mass="19182" checksum="33F7AF95CF5F2DAC" modified="2012-11-28" version="1">MGNEDAPSPSRSSSSPSPPPDRSEATPPPASPSPVSSLPSPAPPTISHFARPKGKLVTYSRRPRPVQMREDSPLSTPEATPRKAPAPKARRGTMSKAKSSKDETPAAKNGKKRSSPLSSPAPTPKRSRKSAAVSAPKATPRGKDDGDSPLSSPAPSDSEPESDASRASTPEAMPKRKRRWGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSP9</accession>
    <name>K1VSP9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSP9"/>
    <dbReference type="STRING" id="1220162.K1VSP9"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017242_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSP9"/>
    <dbReference type="OMA" id="CASAQFR"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="236"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="665"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="267"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="843" mass="85978" checksum="BEF84DA1BF74E191" modified="2012-11-28" version="1">MSLNEARVTDAQSGVSIPLGHGSARIHARRLPNGAVSIPLNAPGGKRDVTFQELRARQNAGAEQPGDHRQNWDDKDGGGQHHGGGGWGWRQNSTNSNNGSGGNNNGGNMNGGNNGGNMNGGGNNNGQNMNGGNMNGGNINGGNMNSGNQNGGGGGGGGGGGGGGGGNNGGGGGGGGGGGGGGGSNGGGGGGGGGGGGGGGSGSMSSTNGQDNGVSTSTSVSEHNNKLINWAGDSRYTVHVHIGTPGVDHELLVDTGSSTMWVFGENCTSAACEASTTKYEQSHSSTANVSDSSPYNITYAAGATKGQYVRDVVSVGPFEVTNFKFGVVNQAGTAPFHGTNISGLLGMGRNAAAITSPPFFYTFLANHDGNSDIAPQFGLHMSRNTGDKDPYKTEAINGGSLTLGGWDESLTTGDVTWVDVVNPKVRYANGTDQQDKWTIASESLSINGHSVNLAGCISLMDSGSPGLGLPLKAVTEFYEQIPGASYAGEGLFAFPCRSVPQQKVSITFGGRVFWIQSTDLVLYQAGGTCIGSVTLSPLAQAYPNFVLVGAAFLKNFYTIHQTNPPRVGFVDLKPEFNRPLTQESIKALLEGRVGLNATYSQEEVMQQNEVAQILQMLNNNGGGGGNGPNLEGQGGGNIGGSGNVGGSNNSGNNMNGGNNGGGNNNGTSNGQNNGNGNNSGNNSGSNNGNWNGNGNWNNNRPPRPGPPGRPHGGGSTWSSSSSSSSSGYRIIQYSTSYSPGWSWTWSSSSSNCAGCASAQFRGKSISTVGNNGIWKTHRHLNPCLSALNNCMTVGREADAGQYAQTFHRREKDCRPIPQAQFDHPQPVGQTIGSGDQDPAFKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSR7</accession>
    <name>K1VSR7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSR7"/>
    <dbReference type="STRING" id="1220162.K1VSR7"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912726_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSR7"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="305" mass="32521" checksum="62780085501CE19E" modified="2012-11-28" version="1">MASGSKSPAAGSSSPVANRNISLETMKTDSLTRQVLTDSPTHSHLLSVGSSRVLALSADKDHIYAGCQGRDNEITVFCRRDFQPEYRLLGHEGSVLCLLVVPEKEWLISGSSAGDVRIWSTRTFEPLYIIHPCDDTSGDIFSLAWDDREGGTLYFGAQNTSIEWVNFGKDIRGTRPVVAPTAVKGNISNLLNGQGHEHHGHPPPSAPTPSQRSGRYKPSPFFDTPSTPGSPGSCTPAGRCTPSRSISCGKGANTPAAAATTGGDYFKRGGDVVEFEVDADSTLFYAHYGYVYALARGDASSPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSZ0</accession>
    <name>K1VSZ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSZ0"/>
    <dbReference type="FunCoup" id="K1VSZ0">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSZ0"/>
    <dbReference type="eggNOG" id="ENOG502S8AU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024413_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSZ0"/>
    <dbReference type="OMA" id="APLCYSC"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="429" mass="46531" checksum="2224476D26C349EF" modified="2012-11-28" version="1">MSPPAWVSKSLCDILGLDSETVNQVIIPDLEGYNTEVRLRGHLSDFLGSTPQARAFADRYVAYRFPSIQPPPPAPVSDPRVDKAKAKAMRQNLKPGKPGTGSSASTPFGSHTDLNSMSRGGSASGSGRGQMRSAGAITIIEKKGKDKGKGKAVEKAGDKIWDLPKSKEVLRLEGIIDALRQVQDGGKGPHVDTPPCFCQARVHELSKYTPQCGACGLILCDMQPPHATCPSCARPTYSPPQLARLIKRVEGDIEVQYAHEQDERDAKERERKEALLAASGGGAFPSLPGNAPRQPSQPQAHRVLTINSIGKKGKFSRSTATITTKTKVTPQASASNTPAEPEPDTLPRPRSPPLDEKRIAKEWAKSAEWRKENDRPWADPKLERKGEIWTYIEPTVVELLGEEGTGRRRKAKKAKNVGIDGRVVVGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT54</accession>
    <name>K1VT54_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane organization and biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT54"/>
    <dbReference type="FunCoup" id="K1VT54">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT54"/>
    <dbReference type="eggNOG" id="KOG2203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011270_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT54"/>
    <dbReference type="OMA" id="PIIKMTE"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="643" mass="72000" checksum="9125BF2AB5ACAFDE" modified="2012-11-28" version="1">MGLLKTVFEVNLGLFGGDADKGRSKDKTLILFVIRDHVGATPLSNLTATLTADMEKIWAGLSKPPHLADTKLTDYFDLDFAALPHKILLPEKFEESVIELRNRFTDRTRKDYVFQPAYHKRIPADGVPFYMDGIWQQVLENKDLDLPTQQELLAQFRCDEIATGVIELFNSSAKALRKPLEAGSVVLGLGASMGDWLKVAATNFDAAASRYHSGVYQRKRLDLLNTLHAVLLPMYLNQLKNARKQATTQFAEGIATSLKAPSYDFAEVVSRCTREARETFVETAKEATLEGSEWDYTTELDSLDEDLQTIADRSRADETKKMVNGIERTVKRQLAEPVELALSKPNKEMWDTVLSSYKTATASGEKAYRAKAASYNCTEDENRAALSTLHSRAWLALRKKLEEQTADTVVLSTLRGSFEDRFRYDDAGVPRVWKPEDDLDGAFKKAREETLALLPLYATVSPVEEKLPELPEPDALDVDMDPEAFDPATAWTLVSPTRLRGLEARFKRDADAAYVEAKRSMVSSISQVPLWMYGALVVLGWNEAMAVLFNPLYFAMLLVAAASAYIVLQLGLAGPLFQIARTVTGEVKRIATDKMREAFAEPQQQRVAVPVAVNATEKRREVRRGPSVHELDETRLDTKFMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT69</accession>
    <name>K1VT69_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_01962</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT69"/>
    <dbReference type="FunCoup" id="K1VT69">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT69"/>
    <dbReference type="eggNOG" id="KOG2527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057172_2_0_1"/>
    <dbReference type="InParanoid" id="K1VT69"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="55"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD03736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="212" mass="24010" checksum="FBFF67FD60D67189" modified="2012-11-28" version="1">MNQQQAGPVHAPTTPSPDATHSPFARADSSQRLTFTDMARLAGRPQTEMYAVPESFLEIEVRNPLTHGVGRKMYTDYEIVCMVSGSDEGGRGRQWTEPPIVTLATLDELFPSLANIQTNIPAFKIRHSVVRRRYSDFEAFRDILERESTRVNIPPLPGKVFTNRFTDDVIEQRREGLQRFLEIVAGHPLLQTGSKVLCAFLQDPAWDKSQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU39</accession>
    <name>K1VU39_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU39"/>
    <dbReference type="HOGENOM" id="CLU_001862_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU39"/>
    <dbReference type="OMA" id="SIRTIMP"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1189"/>
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    </feature>
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        <location>
            <begin position="1207"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="302"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
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        </location>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1333"/>
        </location>
    </feature>
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        <location>
            <begin position="1346"/>
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        </location>
    </feature>
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        <location>
            <begin position="1405"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1686" mass="177233" checksum="CCACC27B0BE78727" modified="2012-11-28" version="1">MSADTSDSALVAAVQAVHANDDPMTWLVAGYAAPGTPKIVLIEAGSDPALPPLRRLLDSDAVAKADATFAYASVQGKGLVILRLGNTVSVVKRAKAIVHSRTFAALFPDYLALSTINKTGQFTEELIAEQLGLDPSTVSTASPPGSTTAALPEVPEVTNGDKVEAATPVPAAAPVSETVIRAPTAELKPEQPPKPMERTPEPTQQPTPAATPPPTAPPTGPPPAPPKSAARARSIKRKPSKPAPPAPSEQSTPQPAVPVASPPSERPPQPSPAPAPAEIPTPAPPAPTATAPVANPLPTPPIAAVSVVPAPVPQEAPTAEPPAEKSRGVLPQIPTAVRTSLAESSSAASVVNPATPPAAATRHERDSMSDETFQREGLGRSALAPPPLLSVSTKDLSDGAPVTPVTTSALTDTTFDSPLPSSLADSPYPERDWSSERRLSRPPSRPLSPDESPIPDRPKSMPLSPQPPKDESLPVQETTVPASGSETFGLVAPRDRPPAQTEIEEPDQERTSQKTPTPQPHATDAPHVPSPAKLPETAAEPAPVAARPLPTADVQRPQPPPPPRRLTPQTAEVLPDGALPSRSSSRTSIPPSLASTARVNGSPRLGSDGPSKLNGTAKQSPFSRLNATNNSSPQPGSSPKQASTATSPPMSDVPRTLHRSASMSSAGSSQGGRSAVSPVSVFSPTMPAPPPVPSHESAEFLAEPELHPTKDIQATGGTGVGGVAGMAGVGAAFAARQALAAHTQDNAPVVERTQLAQVPVRRSSRRALNSAFVAQANEQPTLESTTERPSLESNRRPSVESTRSSLGRSNSLDSASRNRPNVTAGWRSRTPSINSLANAAGSSERKRPLGSRPMRSASNSTTSTPPMVTSSRRVPSPEPVPSAESTTPKPEEKRQTNDEDAKDDSAKPAELPESLSHPAVRQLSLSQSQSTDTSGVATPDSGRSIGHRKTPSGNRKPAPPIDQALIEALKKESVSSDLERLQRSTPTTPVGPPAVSPFMPIEKKEPPTRIIPKKVPPPLPLTATMLNVIPPKSAAGSDKTAVPKGPLSPGLLSPTTPISPRSPISPVSAASPRHSLSSDFMARMNMPVGSRDSTTSRLSQRMSNRLSQFSARMSRRISSDSGHNHRPYMEDSAGSHDFEHSQASVVNAAVARHSTARSVSLSNGRLTPIKTSAPSSSHTSQASLPLPSPVMLNGDYRSARDITGPVEGMVIITADTPSRTTTEKGGSSRETSSTSQDKAEDRTKGTDKTKDEDKIKEEDAKIAPIEKSEKKENGIKRKAPPAADVVDLNDSPQIQQSATLSPPMNTEHFSAVSPQFVNAPRQLSAGTSPSLESSAALLREQRYPETPQMTSPTITTSPPSSLDRHSSLSQKLRLALRSKSNGEHGAQRPDFLPGSSPIASPPSPTVSNFSNSPNPNRSSIQGSLGRAFRLRAGSNSGGHQPMKGTSPGGISSDDFKHLHEKEALHGLGLGMQFPPNSYRTPSGGLGYTPPAKKGRTVSNISAEDALANIRLKNMAEQEEAQERWRLARVLDRTQRRRGAQPGPHLRVLRAHAQLHGAGRRTPDPAPQFSRRAAQAAPAPQLARPRHTGEHAVALVVRLAPALALARRPPLADARQHRDRVLIGVGALAFGREGEQSLARTRRAQRHLPALVVRALRQVARTRTRPAHVLRAAKRAGARQPLPGIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV94</accession>
    <name>K1VV94_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000335">
        <property type="protein sequence ID" value="EKD00673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV94"/>
    <dbReference type="STRING" id="1220162.K1VV94"/>
    <dbReference type="eggNOG" id="ENOG502S1T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_889001_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV94"/>
    <dbReference type="OMA" id="FLRPPNI"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="313" mass="34181" checksum="E8FC77E2DE22B6CE" modified="2012-11-28" version="1">MSHQRNGSNYQDPYLEPGAEYLATDKGSTTQGSYMDGQYGDHQYGSYNNAVPADKLDDDGVHALGEIAPGQRQTAGRAGLQNPTSSFAAMGPPPRSTGILREWRKEERGHQWGKYVRPPFVTPAFDFGSDNVVKEGASLLQTQNASITVNGFYLPFLIPFLVGNPNWFTAEFSKIQADVTYTPTNTKFGEGKLESTKIAAYKTSALNFPFNVNWTTTSNTAGNKKEFITSLLSDCGFNVATGQETTPKDWNMKLALHLTIKVLSVNIAIPTINVNSLGVPCPFKGDDINTLKAILENIPSKRDTLAIEDASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW01</accession>
    <name>K1VW01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000327">
        <property type="protein sequence ID" value="EKD01038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW01"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023630_0_1_1"/>
    <dbReference type="InParanoid" id="K1VW01"/>
    <dbReference type="OMA" id="HYAEHFG"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000368">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854058" description="Serine carboxypeptidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="70842" checksum="B63A01648D8FE8F2" modified="2012-11-28" version="1">MKTTALLLSLAASVQAFDAVSHRRLMNAQIGKEVVAAAPIAPELPAKLAAFAIPGDDADKDADKDDQNEDGDSNNGDESQGKEGDDKDAAEEKPKKEKDQYGADITKTRFGPFCFDQKVSHFDEGEKRTFCQRYWVDSQYYVEGGPVFILDGGETDGANRADDSIPFMEQGILQILSNATGGMSVILEHRYYGASYVTEDLSTDNLRWLNNKESLEDSAEFIRKFPVPKDVQKKLKNKDVFKPDCTPYIYYGGSYAGARAAFMRKEYPDLVFGGIGSSGVTHAQVYYPEYFDPIITYGEPACIKAMEESIASVDELLDKSAETNAALKKLFGLEALNDVDFAGVLQYPTGGWQGQNWDPAVGSTDWADWCRALTVPRSNADATVAGMSVPGSLLNYADYVRDEIIKPSCPSGDIQGCFAEGPDSDYQNTSLSQTWRLWQFQVCTQWGYFQVAPKPGKRTIVSRKLTLDTAHKICKQAYPPGEHFSVPAWPDVHETNSRGSYYIAYDRLAFIDGEIDPWRPVTPNADVAPKRNSTTSPPNWIIPGGVHHYDENGLKDHLKEPKQIQEVHAFMVDFVHKWLEGKDDEGHGHGNGHGHGHGNGNGNGHGHGNGHDNGNHDGWENGKGHDKDHGNGHGNHDHGDHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWH9</accession>
    <name>K1VWH9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWH9"/>
    <dbReference type="STRING" id="1220162.K1VWH9"/>
    <dbReference type="eggNOG" id="ENOG502S7WD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726010_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWH9"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="182"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="381" mass="41592" checksum="4A252DE14F60B444" modified="2012-11-28" version="1">MRSWLASPETSESTCRNVTSLASSTSDIRFDHITTFHNRSRRMAQEIFDTLPALARRLADVREYQIPRLAQSTTLARDLAGEARADLESVRVGLEDARETAELAGARREELLSQVLALEDEWARCVALFTGYRADNSVHRAYRTALVDSKGNQATADARYELDESRLQPEIEESSGVVGVLSVQMLDSSTETLRSTQSLYERYNDLLGASGKIVKALEKADWWDRAIIAAAFTFFLLCVAYVIKRRVLDRVGGFAAWWVGGSFRLLRMGLTGKPARRVVEDVVTQGAAVASGAAVTGAAVAGAAGAAAGAVKQELDKKRAADTDAAESKSKKKSKKDKKKNKKAKKGVKEVKQEPDTVTIIEEVVPSEPADDSAVKVKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWI6</accession>
    <name>K1VWI6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWI6"/>
    <dbReference type="HOGENOM" id="CLU_025463_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWI6"/>
    <dbReference type="OMA" id="YETHESF"/>
    <dbReference type="OrthoDB" id="10690065at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="687" mass="72930" checksum="B93536703734E566" modified="2012-11-28" version="1">MGFLRKIGSSKSLREKASKDAYRPPTPPPQLPPLPDHIRRSESKSTHQSNNTQQRAQRRRSRSLWGTSEEAKVARTGLQRRDSFCGSTFTTDSSPSSQPWRSRDAWLALHTPSTPTIVNELTFPCSLDPPTPGWRGRGGGGFFAGTEAMTDADKIKSARGDDGDSIFSLPPRSRSRAATLASRDSPTPSRSKLAYPTPPLDSGVDDSPMSPTMMPKTGLRRPSHNGSQIESLPPVSALPPPRAVSPVPTLPPTPTTPRAPARSNSVTTTARDSTSSGDHGSQSPVTPQQSTQLLQAPPSNFLPSEAKVPWGQASRSASPILFRNDSTSTTHSSRLSARSSTHSSRARIVYSPKPPSRALPATPPDSDSGHSNEEHGLPYDQPQQQQQHNAVDITDEAGGEVIDFTRPRSPAAEQAQGPSSDDLRRSLSSSRGRRSSIQSSYETHESFNSVGSGAFYTPPPADSPAISGAGAAAAQGFFAPPLPVPAGAAPVSSTLPTPLSRSGPSSGLVIPPPRSTSRPPSRSASRASRSSHGHSSHGHDMPYTPATAQYPTIAQWRAVSADSPSPAPAPAYIPATPQSPPPLVQSLQPQKTGGSLRSMRRSSRTSLHRSMKSASKADSVGVTDAAAWNPASPVPDPFAGPWEQPAPYEIGFNPEHQAYAAPLRLPQKTNRLPSLRGNGRLAKAGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWT2</accession>
    <name>K1VWT2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWT2"/>
    <dbReference type="HOGENOM" id="CLU_769849_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWT2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="41238" checksum="8B73EB55E22E83AC" modified="2012-11-28" version="1">MCSLSTPPTHIKADCGPSSLKRQVSHPTMDSRNNAPSQTRTSAPSSPLASSPPLSPSQSNAPAAITRPPFQRNGGHAGSPGGSQGSFPLSSSTGSSTAAPDVPNPTIHVTSMGSRTSAPPGTPIVPAPLAVIRKHSTIRGCYGVSLETSDAQRGPEPDVRLETRDSPIDATLYLYGVRGGRNIEVARKARLDIRTASTVRLRIQRDENVSVDASVATTKSESKAGGTGGEDFVPMPYLHSKCPGVWRSRPAFTRFLSADATGRIHLWLPNDFDGLLTVHSRKHTLSPCIKDIAIAHDIPGQTSQTWAICLKKDTTDPVLYRTASNSIPAEAGGQVGRERRPSATASDAIPPQPHQRQPGPDRVFAHAHSSVRVYAHIDEEEGSKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWZ7</accession>
    <name>K1VWZ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWZ7"/>
    <dbReference type="HOGENOM" id="CLU_1548709_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWZ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="173" mass="18404" checksum="6FFC0D69F70CD6E8" modified="2012-11-28" version="1">MHTLSSSYQNNSALNIPNDHPFRSSLPPRLHITADGDILSAVTDKYNRRHAAIVDGLAMHSPTADLIDLEDMDLLPSMRPTSVLSVTSTSSWASTSSSTASVTSASTTSNKSDVSRNSAASTSKLVRTLGGDPFCNLNSENPETVTTTLTPHCLSPCDAIKAIISRKSRTSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX03</accession>
    <name>K1VX03_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_00648</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX03"/>
    <dbReference type="FunCoup" id="K1VX03">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX03"/>
    <dbReference type="eggNOG" id="KOG1733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_0_1_1"/>
    <dbReference type="InParanoid" id="K1VX03"/>
    <dbReference type="OMA" id="MAAWNQV"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD05041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="96" mass="10481" checksum="F55DAB7D8A4E149C" modified="2012-11-28" version="1">MSSLFGSSGAATTSQQQKEQLKQQIQQELAVAGAQQLINKITENCFAKCITRPGTSLGASDERCLTQCMTLYMAAFDQVSRSYVARVSKERNAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX67</accession>
    <name>K1VX67_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX67"/>
    <dbReference type="FunCoup" id="K1VX67">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX67"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003043_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX67"/>
    <dbReference type="OMA" id="EPHEAWH"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="5">
        <location>
            <begin position="284"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="5">
        <location>
            <begin position="380"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="4">
        <location>
            <begin position="814"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1041" mass="111078" checksum="88C404E01DA8008A" modified="2012-11-28" version="1">MVQRTQPSSPARRDTTLAEVVDDSDPTYSNFGHRDEFLELLKQFLAANAQATPSPEESEAEDELLDFYLPMPGLLDPAMGDIVPPLMAALGKQLALLTDGREPDPTRFARIGRVVNWVVKVRGWNLSALSTDDIATNLDIPTHERLFSVPIPPLAVRVTLLALPLLSNPGKDGEYGALILARLFAREDALAGLPGFLKWAAAALEEGEREQEANLVASLFSFLAVLPGMAPQKELPILRTFFEDSLIPHLAGSTTSATSGLIRKLATKANGRWWVASLGAGLRDQPDADLPEGIEEVLDDLMSALGDKDTIVRYSAAKYLARIAALLPAELSDQIVSAVIGLFAGSEDDPVILTKFGTVIDPGGSAGGNGTMGLGGQETSRGEARWHGVCLAVAELARRGLLPAEAVDEVIPWVVKALTFDLRRASHSIGSNVRDAASYVLWSLSRAASPQQLKPFAELMATTLASVAVFDREVGVRRAASAAFQEGVGRSGLFPEGIDVLGKIDFFSVSIRRKAFTEAAPAAAHHTVYRKAFREHLHNITLRHWDAAMRVAGATALASLLELDPADIPDSVSRELAQVSSFDSASAHGALLALSRIAPMLDDGGKAELFDALTKVRPGALVTSNAADIVNGGCLLAAAALTSSADLSPLERFFSAATQRRETDVHDSLAALCRVMSEVQPDNSVSYVRRTMSELGAARASTRQAAALCLGSYQYRTAAEISGPLDALLAQFGKDAKADVETRRNAVQSLAQMSLQSADSVPLNALDDYTTDQRGDVGSWVRVASAKSIAQVLAGAASQPNALQLVPQELFTPAIAGIAKQAFEKLDVVREAATEAWSVLLAADADKVWDWPGAEAMATTESGERRVRPSAEWFSAGLALLQTSIHASVAAGIVQSAGAVVHSTSERCLRPLIPWLQKHDESQFVIDIVDVLAANLASNRIAVPALTTLSRLMDAGIEPSEEEAGRMLGLAARGLTTLKSIERLQAAMRVIIRTVTAEALYLAVGDEAESELEELLLETPWAEEGDKARAGRAVALLREMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXG2</accession>
    <name>K1VXG2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXG2"/>
    <dbReference type="HOGENOM" id="CLU_1526246_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXG2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="17870" checksum="4B97C2161DE486DE" modified="2012-11-28" version="1">MSSSSVATPSATATAIPQVSGIPEQCYGKSALKVEDYKWNGTVAGTDSVCAANYNDITLYCCQQAGGSAAWGEKNATASAVAAAFNRVAKNANGTASPDCGLQLCKLPSDKEADFMYCQSEHGAEGSCQTKNASAAAAAGAAGDKKEEDKKESAAVRLSPAGIAMAVTFLASAVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXG6</accession>
    <name>K1VXG6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXG6"/>
    <dbReference type="STRING" id="1220162.K1VXG6"/>
    <dbReference type="eggNOG" id="KOG3683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909699_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXG6"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="101"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="367" mass="39973" checksum="7A98528F3F3822F4" modified="2012-11-28" version="1">MPRHVGTRNERKPESTAFPVDITTTSFESGDHRRRLTTRSFPCCTRHERTAGDRRFEASLPLPRAEFYGQDASYENVEAAYLDSDLNETTLNGVIPQELNDGVLFPRPTLLQLHSITEIGASAFALNTAREQRREVLSGATRIRGIDDDDEDDIDDSKLPAYPRSMLSVEVSDGRSTIRAIEYRKLPELALGETRLGLKMMRGRLLLEPKNCTVIGGCVDELEEGQPQAFVEGLEKRLHTARAPVSAAASAEARAARAAAIRAAMENPDPQEERARPAPVTQITGAPSSATGGPSSGSFANPTVISDDEDEFDDFDDSFIRAIDEVEAAGMGAAASIPRMRSQPTQRSSGRSTIPADAEIIELSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXQ1</accession>
    <name>K1VXQ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXQ1"/>
    <dbReference type="HOGENOM" id="CLU_767658_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXQ1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="355" mass="40491" checksum="5EE49AE4BA1ADA4A" modified="2012-11-28" version="1">MTQLHPLSVPHVFDTIIDSAAPESLPTLRQVCHLFRHRVDKRLASQLSYTRPAAISKRGSLRSSVCPSVWRPCWQQSSDVRLIDFTFERTGHFIDSRLWHERKSVPRYPNLKYARFLHAPACMTPDPEEDEDMRMQPLPTVIVPRVAGCDYAKRRGGMDTVFVHKGTKHVTFPTAAKPTDSVWETKLQVSPRQSVDVTILVLDRPEQDAAATETKEDRTTLPMLQATVRQLMEEHYAGHLSSASLVGLENWRTSIPTLSDKQWDALIARRIRETAERGEYADFDVSAFLSAVKVKSTTEWREEVGEEEYELSESAYDPHRAWLIQECGWDPKAVKVEPVPQTRPTSSDPRLAFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY11</accession>
    <name>K1VY11_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY11"/>
    <dbReference type="STRING" id="1220162.K1VY11"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_0_3_1"/>
    <dbReference type="InParanoid" id="K1VY11"/>
    <dbReference type="OMA" id="ININRNM"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="219"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="359" mass="37591" checksum="4C161B01378F0773" modified="2012-11-28" version="1">MADDLDLDMAIEPLTPAPQPSEPATAAAASATPEPNEGGNKSRSVTRVQPGFITPEGAGARVSRSIGLPSLWNLSPFLILDYCDIEPGQGFPDHPHRGMATVTMVLDGQVTHEDHLGHTGTLGQGDLQWMIAGRGLVHSEMPVGAARALQLWIDLPAARKMMKPRYVDRKSSQIPSVPLLDSSSAEVGSARVIAGEVGDTKGSVRDTVNEILLLDLTLRGETFVAVPASWTCFVYATEGSISVGGKKVKAQECAVLSTSEGETGVHIEAGGKGARVLLGASPPLHQELVMQGPFAVTSRDAAGKALADFRDGRNGFEKALGWRSKTGQAVSSGAKGKGGKGGKGKKAKRGRRGDDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYL3</accession>
    <name>K1VYL3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000005">
        <property type="protein sequence ID" value="EKD05691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYL3"/>
    <dbReference type="STRING" id="1220162.K1VYL3"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000998_1_0_1"/>
    <dbReference type="InParanoid" id="K1VYL3"/>
    <dbReference type="OMA" id="NQNMRWA"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="474"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="869" mass="96248" checksum="08421AC930C99AB2" modified="2012-11-28" version="1">MPYQREADPDANQQAQPYDPCHPSQQGQQPQPPTRRSSQSSQSLLERYSSHGSQEGKEEKSPYSGPGPSVADIEGAGQAGGAGVMQPHIQFMCGPLLNYYSVVNGVWHGAALVVTADKGSILNPPPYLTISLGGASEKIGGQCILTYNDVTQGPCSFWRFMIQIPLQDHEAKVYYSINGGGELSFFVPARGQNMRWVAHSCNGFSGGVNQEEFKGKYDTGFSPLWEDVLVKHSEQPYHCMVGGGDQLYCDAITKEKELQSWINAKSRKDKVNHALTDDMKIAIDRFYFNHYCKSFRSSAFAKANSTIPMVNMLDDHDLIDGFGTYDDETMASPVFSYIGTRGYFWFLAFQLFTVDAIDGQGDGPANHPIPSMLIGEVGPWLQGQRSHSLITYLGPKVAMLLLDCRAERRLTQIVSPKTYQKAFNAIAQLPQSVEQVVIQLGVPIAYPRMSFLEHFLEYKWNPITMLARRNALGLGSFVNKFDQSAELLDDLNDHWCANTHKKERNWLVLEMQRIARTQNVRITFLSGDVHLAAVGKLFTHKRKLRTPVTPEQDHRYMLNVISSAIVNTPPPAGAAKMVSILAGHKHRTLHRKKTDETMLPIFNKDTDGSTLKRPFILARRNYASIDYLDNGALRFDIRVEREQGAGETVSYPCESPPPRYLANKSVTSTSTSPVTPTTGRFANNDDISVVSGAPQSFAPSTNGGSATNLAGLAQAQRREQEKYSSAHAHAQKVDEAFGRGAEPKPVNPHNPAEQAYEHAQPGQSNQQFAQQQQGQYRQPAQQQQYQQPGQYEQQQYAQQSGVPAGQPQQYQQSSYQSAGAYGQDSYAQQGTHAQGYSQNQSYAQPAQYAQPGAQMQNVGALNHAAQGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYQ5</accession>
    <name>K1VYQ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYQ5"/>
    <dbReference type="STRING" id="1220162.K1VYQ5"/>
    <dbReference type="HOGENOM" id="CLU_063146_1_1_1"/>
    <dbReference type="InParanoid" id="K1VYQ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="221" mass="24522" checksum="92E9CD9A0D03DD3D" modified="2012-11-28" version="1">MGLFGKKKEEEPEPIPLLDPVEPPISVFPNMTRDRQVSLEYRQKLMTMKTEDFTVFDSDNDEPIVTVTGPAMYARKFKTVTLPNGEPLFKMRVKLAAVNLRIICEDAERGTEFFQINREWAWKVKLNLRQNLTVGDSPTLHLVGSAGGSQAKVTLKDSGQLVAVLDRVRWGKEGMQNKLTYRMAVAPGVDLALITALCLAWDKAKEDDRKRAAAASSGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2E0</accession>
    <name>K1W2E0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polysaccharide biosynthesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2E0"/>
    <dbReference type="FunCoup" id="K1W2E0">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W2E0"/>
    <dbReference type="eggNOG" id="KOG4093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103791_1_0_1"/>
    <dbReference type="InParanoid" id="K1W2E0"/>
    <dbReference type="OMA" id="IQFYAFE"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="166" mass="19711" checksum="87B1B302DD27A271" modified="2012-11-28" version="1">MSAITDINNFNAEEAANFEEIEQQFAVKTVEHLEAYQKLLENVNPRTLKLTNMDDEIFEDIMTRFPEFKDTEKLRVLDEDKMKSPEGKQRWRDFIMPYEKTLTDYNFGTLIRRDADREYAEDNCILVTRAQFVGLEIARNRLGVNDKFYQEHQKKKDDVKPAATRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3M6</accession>
    <name>K1W3M6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3M6"/>
    <dbReference type="HOGENOM" id="CLU_2160185_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3M6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="11826" checksum="7D4AF0809F23A2CC" modified="2012-11-28" version="1">MEANLETNAGQEPSEAKSTEQVVNDGKESRDKAAEGSIEVERGKEASNGALETLDSTEAGEKPPGRTDRWPAVIGSGAPPPPPLSKSTSRDSFLNTMFMHDVRPFRGISQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4A1</accession>
    <name>K1W4A1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arf/Sar family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4A1"/>
    <dbReference type="STRING" id="1220162.K1W4A1"/>
    <dbReference type="eggNOG" id="KOG0076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_7_3_1"/>
    <dbReference type="InParanoid" id="K1W4A1"/>
    <dbReference type="OMA" id="HGFYKYM"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18726" checksum="13316AB7E84DE262" modified="2012-11-28" version="1">MLEKIKTLYNPTPGMAPDKIAPTVGQNIGKINLPSTIMQFFDLGGQRDIRSIWPKYYDECHAVVFVVDASDQARLSETWEVFDDVITSPRLLNLPLLLLANKQDKDTSLTVAEIRESFEAWQRARPGKEDEEAAAPGPSSEARAADVVDADAKRERLASLDVLGVSALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4E4</accession>
    <name>K1W4E4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4E4"/>
    <dbReference type="HOGENOM" id="CLU_811795_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4E4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="342" mass="37746" checksum="8E9DFA24F34754C6" modified="2012-11-28" version="1">MSSFSSNFPSNSTRTPASRRRPLSMYGSDMSSGNVMTTSAYDSLDDWGGASVLQRGLSSQNLEIIRLNSEVALLKEQLAGRPTQDDLDELKNEWQTTEQLFAESQKPQLEGESDPPLAKLTSGMLRPAIPQPTAIPGIDEHAPARHAKLGAMKASTSMSSSTSVTPLSRSRIDSRPSHSVRDYDTSTSSNDRLDVDVLLGSQLQPANRAPPRQASPKSPTPASRDRVLEQVETLTGMIKSMPSNLVETVLEQLELNEAMRKQSESRKEAATKKEKEEDLKLAESKLERRNQILLEMLDAAERRAEARELRLQTMLAEPVGRWTGEHTLDAASSPRHTFDHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4T8</accession>
    <name>K1W4T8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4T8"/>
    <dbReference type="HOGENOM" id="CLU_590775_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4T8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="515" mass="56199" checksum="E92A056499D1FD45" modified="2012-11-28" version="1">MASKLANCEPPGPLGYDEYWRVGDFELITSDGVCFRVSSTFLGCWSGMLDAGSGPKIIELDEPSIGVHGFLSSVENQRLDQLWMEQDLFARAVSVLSFMARFGCDAVLEIALASLKRRVQIGKWPRFLLFLVGAILRCPTLCEEAVTPSPEYVPDATWGTFATALRPPLACGGLGACTLDFRGHIKQTLDALPTEYLCALAAWDAATHMLATRLPESVKFGDYLDMFLGKPTVVGYTQRRAYKSSQAMQRQMPIKPRKHNGTHENISPRQHRLPRNTPASGQSDSATASAGPSLDPRLSRRLALAKHSKNARQQVVEPVVLLKVSVVNGPCPHHSNTCDSYKPSACPVQRAAGAAVQCAGPHCTHQAPKQPNNHVALPFDSQATHPATQYDVQPASQQTTQQLAGQPAKQPTQQPSKGFVKRAMDRSKRQLSKLIAKMSFTPRVKHSHEAAVNHSLEQSDQTTKQTSEQPQTSLPPRSPPPRAEAPLVALPRSPPSPVLDPSAGLSECKNHRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5N8</accession>
    <name>K1W5N8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic amino acid transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5N8"/>
    <dbReference type="STRING" id="1220162.K1W5N8"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="InParanoid" id="K1W5N8"/>
    <dbReference type="OMA" id="TQGYPPL"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="115"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="473" mass="51194" checksum="9F53184B6C7CA391" modified="2012-11-28" version="1">MVESSAIEPDSKVSSPFQTTPRARSPSCAAAPNFLSDRAASTEIDGTNKQSADSCPSRNPASSPSCELSPSRVLADSSAGRPNPTTFPFESITLNIKPPLDGRSSESVAVQLDGEALNEALQYGPSAGLSSIRGWLTDLQAQVHKREIGENWAVSLGSGSQDLMSKCFQAVLNPGDPILVETPVYSGVLPTLRQLGAKCIEVDVDDEGLSADRLAAILDNWPTGEKKPRVIYSTPVGCNPSGCSSSAQRKLDVLQVMKKHDLLMMEDDPYYYLTTPLIPSYFELEKQVFPEGGHVVRFDSFSKLLSAGIRLGFATGPKDILHAIDVHTAGANLHTSALAQAIAHSLLSHWGIDGFLAHSRAVSEFYRERRDRFEATARKELGDLATWVSPVAGMFLWIDLSPGGIEDSYKLIRNEALAKGVLAVPGAAFYPSGRKSPHVRVSFSVIDLEDESPEGFRRLAEAIRDKRKELGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6X4</accession>
    <name>K1W6X4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6X4"/>
    <dbReference type="HOGENOM" id="CLU_906700_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6X4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="307" mass="33522" checksum="235B0CF510BEC96D" modified="2012-11-28" version="1">MIITKREKIPITEAYLAGKTVDELHAVAGEHGLTGALKIKNKSELKRFLMRYADASTKENAIIIPPDQEQTTLAFKVSSASTSQNGGKKGRTKTKSNNGSPAATKAPATLHSIPLSPTRQLKRPRYPRPSSSSHPDSAFRLPKGVPVISLLSDDDSDDAAIERWLARPPVDASSRPQQVQRPSGITSSSTSPMPRVLDDSQPQIPRDETDEEGEEDVDQLSWSDEEETAVPTHVARARKNKAAKQSRQQRNDRSSSTARPMKRGRPSDSGRPAATQTQPVVSTQPSANDARLLSPPALPTPRWKHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W798</accession>
    <name>K1W798_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_08101</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W798"/>
    <dbReference type="STRING" id="1220162.K1W798"/>
    <dbReference type="eggNOG" id="KOG2858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839885_0_0_1"/>
    <dbReference type="InParanoid" id="K1W798"/>
    <dbReference type="OMA" id="VPMNQYG"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="259"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="331" mass="35738" checksum="5281537FEF3F12B2" modified="2012-11-28" version="1">MPLPAPPSNLPAKPGSAPVQEPVKTNACQVCGTEAKYTCPRCEKRTCSVACSKAHKAADNCSGVRNPAAYVPLNKITQGTWDGDYTWLEQGRRQVAEWGEGITAEEAERAAKGETPRRGRGGARGGRGIKRSRLDGLRWAANEIGAEVDLVPDGMQRRKTNQSSWNANLLPPDVLAKQPILALPYYYPRSRDVPDPTPPSRATKYFTPLDGNLPVDQALNGTAFVEFPTVRVFDRTEWLGKLGNGEVAVIPRFETKVAAEEKKSVPAKRERPEELGLGLGGYGSSDEDDAEEGEEADGGPEEAETKDITLSPRMAQALGQALEADFGPIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8K9</accession>
    <name>K1W8K9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8K9"/>
    <dbReference type="STRING" id="1220162.K1W8K9"/>
    <dbReference type="eggNOG" id="ENOG502QUU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063146_1_1_1"/>
    <dbReference type="InParanoid" id="K1W8K9"/>
    <dbReference type="OMA" id="LEMKGNW"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23563" checksum="5884AB6C3E51C8CF" modified="2012-11-28" version="1">MGLFAADTGLTLQPVHPPLGLNMNYVNHPVVTLVLKEKVFSWSGDDFTVTDTEGRPVVKCSGKMMSMRGRKTITDAWGNYLFTIREKIMSWRTTYLGEDQNGTVLFELRNRMSWGSKMSIKFTNASTGQPVALLLKGDMFGRSATIFIEDGPPIAMIKRKGMNVSNLVFDKQTYFVDVAPGVDLALMAALCILLDEIENDQSSGGGGGGGDFSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8Z1</accession>
    <name>K1W8Z1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8Z1"/>
    <dbReference type="eggNOG" id="ENOG502S7AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248579_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8Z1"/>
    <dbReference type="OMA" id="PAMYSAG"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1492"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1503" mass="161925" checksum="18A96191DB626C89" modified="2012-11-28" version="1">MPPKKEKKEKRLSRLTGWFRRLSIDKLPSPPNKHHVRAADSVSTMPVPHTVAGIVDHDRRHSFNEFGSRSAASQSMPNKAGYRKSMLRNGFTFGSSAPPTPTDNIGTAQRLTANSNSEATHETTSSDRTLAATPSATLLSGEAVNGLALSVTSPPSTASTPAPSIAPSSVPSIHPGPPSERHYYDHPPASRLPLPVAPYARSASTAPSRSSRDSLSNRDAHREALRQSLRLRVADPTRPVVDYHRAPGVIISLLAILDKKTLLTFRLTCRRHAALVNELYGAHVVVKGGAGGYHAISALGRAPVCYNGRPYGRGKPYLAVVGRVGVLSFEGGLRTWDLSERAEAEAAEQRLRHRLPRVANAPVVRVSDLAFAFESDVNPSTFVWFQTEGYRETYVPLSTRRLVVNLWGNWRFPILNYPDLDLEEVIVHPSPWIRKEDWTFRAECVAVIARTLLLDLVTLPQPKAASPEIRISSDGDDMGTHSTPRSSSDATNTETTGVIGEPNNKGKGKVSAAPSNDSDTSSPPQPSTPTPNDYRKHRDIRVTVVGFDPIDERHHATLPGYKRYSLPLVRDQKIGEWKRFTSAHEELGDLMSVLSRITFVSEKEYRQSVGERRPAPCPHLRASHTKSGSSPLPLLTALSLDTYHLRLSKYDPVTTIHDATDFSLPKLSKSIPEPLCSYRPNIACLPPPVSRIHPAMYSAGVATRTRSRATLSSAPSVKKPAVKHVRSTRRHPLPPSAEPIPAELRGKRKLSGGEAPSKRRRSNPRTSGTTGVEDVSMTSDSGQSSGTANSSLTSSDGSSQFILATPSKAPTSTASEPVPKPLQIQPSFTPFQTAPSTPVMVNAEAGPSTPPSDRVSDLPSAVPSTPAAQISHPQPVAPTPAREILRLTPKELKTAADTILPRPPTPPKVTERSARNGYPAWATPKTTVKKPPSAFFTRQAMTTARPGIRAPEPVQPVPFALQPQVQLPPRMDRPVAALPNRARVHPLATPARQPNPLATPATRKITVPVPFGGSVSRSTQAAANRVMATPSKTSHTTPLSLPAKTPGPALSKPPPPMLHIEETDEMDVDTPANLPVSNTPAAEKPADIPAVEQANATPAPAPSAATEGPAATQAEERVIATAAVPPKTPAPAPAAPPSTVAGSTRTLRKRAPTIATSLPARRPHSRPASVAGTVMGPPPLKTSSVDVPNKAADGPRYPSSLGSGPLNRPGSRVVSNNYRSISAPTPSSAKIEEPSLRSLSYPAGRDKENASQGQVKAKPRESLSMSSRRADTSLCISSLDDTLARLKARNKPDFKAAPKRVLSAAAVQDDKTDKTKLLGVTPRSLSLASMPQTERHSAPSRFQVLVDNSQQTAVLKGVVAFVDVHSAEGTDGSAPFIDMLKLSGARVLKRPSESCTHFIYKDGKPSTAAFWRRLPEAKRPEVVGIRWVTMCRERGKWMEEAGFRVDLNEQDIFQVSMEPKRLEAKPFLTKLSAAKAMPQPPPMPKKQPYATKVSSPLRQTMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9S2</accession>
    <name>K1W9S2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9S2"/>
    <dbReference type="HOGENOM" id="CLU_1397232_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9S2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854658" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="175" mass="19538" checksum="954161487AEAF98B" modified="2012-11-28" version="1">MFASIIPLALLVAPAVSGAASWWTIRQGESFLRLVECYQSDSDSTDEPHVYCTLNLETPRLGPLDTCHVKWFFDPAVTGEVTTEAGHFLGSRAWEPWNGGRIDMAPAVNMAGVTFLSAENRTWTFRESGHIELGHTNYCLDFKDGNIGTYGTGLFQLWECVDHNPNQIWKLCARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA77</accession>
    <name>K1WA77_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000043">
        <property type="protein sequence ID" value="EKD05658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA77"/>
    <dbReference type="STRING" id="1220162.K1WA77"/>
    <dbReference type="eggNOG" id="ENOG502RSB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_6_1"/>
    <dbReference type="InParanoid" id="K1WA77"/>
    <dbReference type="OMA" id="GSCMCGG"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="136" mass="14446" checksum="F017722898411A62" modified="2012-11-28" version="1">MPSGSCLCGKIAFEYTGEPALTALCHCHACQKWCGAAASSNVIVPRDHFKLLRGTPSVYKQPGDSGKLNARHFCGNCGSCLFGELEIMPDVFGIKAGSLDNGAADYKVCNTEFYTESRLSFVKAVDGAAQEPKFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAK7</accession>
    <name>K1WAK7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAK7"/>
    <dbReference type="STRING" id="1220162.K1WAK7"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="InParanoid" id="K1WAK7"/>
    <dbReference type="OMA" id="GKHAKGF"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="106"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="643" mass="70943" checksum="137B17B99FFE58A5" modified="2012-11-28" version="1">MKSDKQEDQYIEQYDDAKADAMAGRRGSHMVGGMIIENPLQVAVMGRKFAATHDLAEKEDLFERAALVARDPDNFQSLTCLSPEEQNQLAFERDHKWRVPKMLVFTMFVCALGAAVQGWDQTGSNGANLSFPVEFGLLPPPATEGAQRRDLLPRAGPAKGAGQSRGDWIVGVINAAPYLAGAIPGVWLSDPLNHWFGRRGEIFITAVILVATPIGSGFSQTWYQLLAIRLVMGIGMGAKAATVAVYSAELAPTRIRGALTMGWQLYVCFGIFLGFAANCVVMNVKDIAWRLQLGSAFIPALPLACFIYLCPESPRWYMKKGKYRKALHSYERIRNGEIIAARDLYYSYVLYMEELAEARGAGYFARLRDCFAVPRIRRATVGASVVMLAQQMCGINIISFYSSTVFVESGFSDQQALYASLGFGALNFTFAIPALFTIDTFGRRSLLLSTFPFMIITLLGTGLSFLIPYHEGGSKARLGVVATFIYLFTCFYSVGEGPVCFLYGAEVFPTVQREQGMAFAVFVNMLFAGVLGLTFPAMKTAMTPLGAFCFYAGLCAIAFVLIFLFVPETKGISLEELDDVFSVPSGRFISYQTKQWLPYFVKRRLLCNSRAQPPPPLRANYRDRAKSGVLEEPVDIAEVDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCT8</accession>
    <name>K1WCT8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCT8"/>
    <dbReference type="HOGENOM" id="CLU_2172842_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCT8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="110" mass="12122" checksum="624C6933A2B00F88" modified="2012-11-28" version="1">MTENAVTRFCLKVVSSSGTELYRGCKDRFPTDVPTYLSGVVNRLHELNLEFESSVENGDIHQYLVAVSEGSEAPTSQQCRYVVSGSWSSFDKHEKGRRTAEQATVGGTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD18</accession>
    <name>K1WD18_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD18"/>
    <dbReference type="STRING" id="1220162.K1WD18"/>
    <dbReference type="HOGENOM" id="CLU_409502_0_0_1"/>
    <dbReference type="InParanoid" id="K1WD18"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="671" mass="74991" checksum="FFB421BB78F59F18" modified="2012-11-28" version="1">MPTPVDLSDLPRRPWTSMEHSKAAAGPMPLGDDIQQDSSYSSFTNATLSTGGLLAPLPLSPSRIVAPQPETIVTPSDPLVALGFDIIYHILPYLQVGDILNLQATSKTWYGALGAGKSLWRKRVEAAVSARRMRELDKIVLNRTTKAEQDGQPLKHFEISKFLRSTSPAHHARQIVVDRDARLTYALTAERLDDEEEFGTEALEVRDLDTGTLLARAGQLPIKGTIVAGHGFVVIWWATALAHGVYPLAPASYIEVYKVGYGPRYSHRKVRPELDLHRGRLSLVKSMARNYWVYGATIHIDTGTRGRRTTLAIAAVPSKLSNDKYAACSLYGAMLGLSFDNVPPHWTANRMGNRYVHFYNLDLPGNKEYSVLDLGTIIGFHKNITIDDVYVFISSEANVRIHARYEPDFVVELSLHSKYLLNSSRLSVQLQRYHEIEVRAAVHSLNQQLYDGELDSRNLDFEKMLDKELERSRKKPPSPRQDVVHSTFHKDPERFTKVAVANRHLVITTIKGKIMVIYNYRELLDGMDASRLNTFQRAAILRNNMMVISTDSNVLDLSTYGNKIGIRLSNGFHSRREDFLLFLDGGFLPDLNDTQNPVHLKSWAIISPINRSILACGKETGGMVIDDFGICLPGTQKCELLQPQAKLTPRPPILPLGPFAVIVTPLLVFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF80</accession>
    <name>K1WF80_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40s ribosomal protein s23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF80"/>
    <dbReference type="FunCoup" id="K1WF80">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WF80"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="InParanoid" id="K1WF80"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="145" mass="16007" checksum="F94FCCCD63CD6555" modified="2012-11-28" version="1">MGSNKPRGIQAARKLRTSRRENRWADKDYNKRALGKFYKTSPTGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFTDENDEVLISGFGRRGKAKGDIPGVRFKVVKVAGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFC2</accession>
    <name>K1WFC2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFC2"/>
    <dbReference type="STRING" id="1220162.K1WFC2"/>
    <dbReference type="eggNOG" id="ENOG502S7YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256836_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFC2"/>
    <dbReference type="OMA" id="SFDIYLV"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854378" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="220" mass="22109" checksum="246567DCC4AABD98" modified="2012-11-28" version="1">MLVKATTLLTLLAAVKAISITQPTDNTKWNGGETTTITWTSVSTDEDTFNLAIKDKNNDVKIIAENVDTNSHSYSYTPDANADGDFNIQILSAKKNQQNAILAESGFFEIQPSTNANAAQSSDSEASASATSSADAKTSSAIPNKLTSPSADIKSGAAGQTLSMSAGENQPSAQATNGNTNGAAAAPSGSAAAGTKEAGAASALVPSLALVGGSLLAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFL4</accession>
    <name>K1WFL4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFL4"/>
    <dbReference type="FunCoup" id="K1WFL4">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WFL4"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFL4"/>
    <dbReference type="OMA" id="GEKTWQQ"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="6">
        <location>
            <begin position="320"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc knuckle" evidence="7">
        <location>
            <begin position="960"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="787"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="934"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="984"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1029" mass="116789" checksum="435592F2F4AA59BF" modified="2012-11-28" version="1">MSEGDDDVLGSAFGLGSVLADVGVDANALSAFLEKTEGKRSRDIEQALEEEGQYMDDVSDDGLPEETEEDKQARRREQAAIKAEEERWARRAANDLKAMPTDADKRRRQKREETEKDRVMTVWPDYKPGTMLKMSEVFYETPAAAQSRRAGILKKKRRLLEGPPKEELDQPKKSSSKVSFLLPNLPSLPGSDQTKSSYLAPIGEWFDPDWIKDAREIRREEMTRPPPGIDLNGDDGKMLDLADWESDVIMDPDLQPKRVHDPNQLRNTHIDAGDWLREVVWDARLATPDLVEDHEDEEEAETQETKKTESTEAVSKLDKFNIGNDHLYEHTRASRYRIRQTFGAIEVFHSIPAQILQMPFYKTTLNKNEARTWHRTPLQFPNNVWLSFAKLKPNPNKSKGKFVADPAERFKTTKDLSVTEKCPFALLEFSEECPPIMSGYGMGTTIVNYYRKKDDKDEHVPKLELGQPSILNVGDAEPFLLGYVDPGKVTQVIHNNLIRAPIFKHQPENTDFLVIRQTINGHATYYIREINHLFTVGQTVPNMSEVPGPHARKNTTTAKHRLMIVAWILIKKNKDPEKQRVKLARLLKYFPDQTELQMRQRLKIKGNEFLEYDHDSKFHSGYWKLNPKYDFPKEKKDVLRMVTPEYASLYEAMQVGAQHLRDAGYTKTADGNAEDEFGDKGEEGLDVEQRLAVWATTLNYKRAEAQKAWLQVHGDGDPTGRGEGFSFLKTNMKNYFLRKGETEEGRRLEAEAKAGGGPVKISNAEQSRIYEEEKRKVWDLQWAALSNPKPPSLTQEDEHRSSATEPTPAGLAPRFAKEPPRQFSRAGSLAAPAFDSPMEDMRSPSAMSFDGESQFTGNDRAAAKVLRINRVVKGKRTVEIVRDPQVITSYLRRVEERKLAQYTDELDNLKPTGNMEEDELKIQALRQEVIRLKKNQQRRQQRKKYAGKGELPDVGEGEGKRRCGACGAYGHTKANRNCPKFNQNVAPSPSTTTPVNPTPFGYGMMDAPVQPTEQAGPGPMKIKLALGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFQ8</accession>
    <name>K1WFQ8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFQ8"/>
    <dbReference type="STRING" id="1220162.K1WFQ8"/>
    <dbReference type="eggNOG" id="KOG2763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032862_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFQ8"/>
    <dbReference type="OMA" id="QFNYTFL"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="333"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="492" mass="55292" checksum="6D6B707DAF64CD06" modified="2012-11-28" version="1">MLRSMRSSLGLGSRARAAYRSAAARTVPTPTYFSRGNATAATPVKTEAKQEAKQQYVTLQEIDRLLTHISQSSKKAKDDTPLVMRAHPVPWMKPEYITPELSGQAAKKKEEVPPLTAEEKKQFMAPKHMSASYTSFVLPLASNPRLYDKYVNFAGGFQHLDSLAGAVGYRHCLARDDRDASEDFHNQSARAGIFIATASADRLDMFGCLNHENVRDLKFSGFVTWTGRSSMEVFVKMEGMGKPGTDKTDTLMLGRFSMVCRDSHTYKAHPVPPLIVETPEEQALWDIGQAHKEERGRLSKLTLDKQASRDLHSFMLATRGKHELDGKKLIKMKDTEMSSVQIMFPQERNLHGNVFGGFLMRQAFELAFTNAAVFAGKPPRFLALDKIEFKLPVPIGAILWLKSKVVYCEEPTGGPYGEAKMHIIVKAEVEDVKTGSRNETNTFFFTMVKDNMENLKKIVVPDTYIEAMQYLEGERRIEVGDEVRRLYQAGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG68</accession>
    <name>K1WG68_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pria protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG68"/>
    <dbReference type="STRING" id="1220162.K1WG68"/>
    <dbReference type="eggNOG" id="ENOG502SA25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115537_0_0_1"/>
    <dbReference type="InParanoid" id="K1WG68"/>
    <dbReference type="OMA" id="HELDFEC"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852857" evidence="2">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="206" mass="21722" checksum="DD77A12BC05A665B" modified="2012-11-28" version="1">MIPRRLVLLFFVLLATTVLAMPAADGGLSRPKRTRGAATKAATGTRLQQAAAAAQKRSAAKGKKATKVQARAPQASKRMGQRKRAKVQAPAAGKKDYSSFLCPGGSVACPVNDADPTVLKTQLNSVADWFRVGFECVDLQTELEQCGGCRALGKGQDCSTIENVKTASCEQGRCVVLACAPGYNVSADRDACVAGGSAQQPLRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIS5</accession>
    <name>K1WIS5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIS5"/>
    <dbReference type="STRING" id="1220162.K1WIS5"/>
    <dbReference type="eggNOG" id="KOG3904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIS5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="82"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="398" mass="44503" checksum="8C65C796D037FF5E" modified="2012-11-28" version="1">MQPLRLPQDDPQPSVSATSKPVSDIAHLSYVGSHPAPRSWDCTLPAITIVLDALEVLLRNAPEYAVLPLSGRGTQADRAQAEFQLTVSVLLLSPTNQILLLHRVKTSSAFPSAHVFPGGTVSEYHEEPVPPPGNPKRHWDSEAYRLAAIRETFEESGILLAKPKGQESGSELLQLNDETRVKGRKATHADQIKFTDWLDKVGGVPDLNGLVPFTRWITPPGAPIKKRFSVQMYIYMLPLGQPTPDTAHDGGLEHTEAEWADVREWVRRAQSGEVMLYEPQAFPLHVMAPFFPQGPNRDYAVERKNLLEFIHRVPTGDSGHWTTQIPWKDKIMCPYVEGQVDDGRVIISCEHPGPEIADEERRGGCADRMVMINTWTQNPRNAEMVLRKDAKYKPVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMX5</accession>
    <name>K1WMX5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMX5"/>
    <dbReference type="FunCoup" id="K1WMX5">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMX5"/>
    <dbReference type="eggNOG" id="KOG0997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014574_2_0_1"/>
    <dbReference type="InParanoid" id="K1WMX5"/>
    <dbReference type="OMA" id="QQPFNAK"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="263"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="362"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="477" mass="52239" checksum="3DFDEE7E55F5FFBF" modified="2012-11-28" version="1">MSAEAPEREPCSGTSTPATPPRARSPYPLALTPSKATVSAASAIASPGEPSPRLLPSTPPTPDVRSKGKGKELQAQDEEAVGKLSVSSDARSELRQQLLREKSWRPSPGRSRASSSAISAKADRRNHGEDEDSLTNMMGVAQALISIFQTEDDAPRMIKHGDSKVVFNIKENLYFFAVSDWGEPEYIILSVVSAAQLQRAFQRRSNFDPSRLLEGSEGFLKHLVGSCQDNLTFMTSTLEVLRMPPALRDTAAAALMPPSKFKTSSSLRTIDTWLPVCLPKFNTAGFVHAYISYVTDSVGLVFISADRDAFESLSQWRVSVEAQLIKDGSLEKIEACVKQHSYAVGECYSFYQLTPGAIGAPGLRHFVYKSRGLIQSTAPEWEEPYGPDSADRKRLITLYQRAQDALYARSGQQTPLKLVYLATNNEAVLGWLTKPFELYVAVSPKLSMSAVVGAANRVAKWVAAEESRLFLKDAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQ66</accession>
    <name>K1WQ66_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQ66"/>
    <dbReference type="STRING" id="1220162.K1WQ66"/>
    <dbReference type="HOGENOM" id="CLU_369693_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQ66"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="753" mass="81695" checksum="A1DF9530595169E8" modified="2012-11-28" version="1">MPTTQHTFPVIVKTTFYRPSLTMASSKRLFEGLNFFLQYSDRPKETFFSDLRLIRKNDGRTTRFPLNSKPTHVVVDIPGQFRFHTYSLPAHPPPSTEPPVKWSLDQLMEHFTSPETDDEVIVVQRQWITDCIRHGKLLAASDEWGGWRVRRRRSSPEPAQDLSEVRGTGEATTARDSARPVKRSRMTRSASDTSPPRNLLSHKEFRNKRPVSFIQDDTLAERMSRSHSPTPTRAHRMSSEQPAPLTIRIPRFKPIASSSNPTPAPSVSSSARLSPPTSDSPAVSHSTQASEAAPNPNPVVDTVSAPEPESDNSFVLETPDTSFEPARDSLLSVSSVSLHLDSAEANPAIESSGTDNEEVEPPFAIIQRLRLGSVTTMTHLWEQQEQQAVSSGKAFSASGAGTTGLITDNLESEAPSEEPASGLDDSMPSELHSGAAAAVNEPAAPDKELGVQADQVELSGNAASHSGSLSTNLNEAEEKLAVEDQGSSGEDELSSLGASHTHDYQALGDHIQGGGSSSASDVVRRLVADMVMDVEQQVEAVLQANHSISSPVHSPPPIPNTPAPVRPTGVFGLFSFGLTHPMSFFVTEGTEPGIPRMISARFIIVPGAAGAELSREHQTLANGDGIAPWARVVHEQWIKHCFRDQSVLSPDDYLARPSAAPASDVEIESISSDDDDEASDIPPRDVLVRVNKIIKAVRDWRAGKGSTKTTYKTVYNFVDNLSSSQGIKGAANLYRTYRAYIARVAPDVAKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSQ4</accession>
    <name>K1WSQ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_01683</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="14">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSQ4"/>
    <dbReference type="FunCoup" id="K1WSQ4">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSQ4"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_5_1"/>
    <dbReference type="InParanoid" id="K1WSQ4"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="99"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="289"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD04009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="558" mass="61915" checksum="96C69C43FFE4FD31" modified="2012-11-28" version="1">MSAAQVKVDKTKKRKRSSKGAADEQPAADVEVDAQAPEQDTDESPEPSSSKVKLDDAPNGASNEYERVPFSSLQLSRPTIDSIARMGFETMTEVQARTIPPLLAGKDVLGAARTGSGKTMAFLVPAVEMLHQLRFKPANGTGVIIISPTRELALQILGVVKDLMQGHSQTFGIVMGGANRKAEADKLVKGVNLLVATPGRLLDHLQNTKGFIFKNLKALVIDEADRILEVGFEDEMRQIIKILPDDNRQSMLFSATQTTKVTDLARISLRPGPLYINVDEKKDTSTAQFLEQGYVVCDSDRRFLLLFTFLKRNLKKKVIVFFSSCNSVKYHAELLNYIDVPVLDLHGKQKQQKRTNTFFEFCNAPNGILLCTDVAARGLDIPKVDWIIQFDPPDDPRDYIHRVGRTARAGKSGKSLLFLLPSELGFLRFLKVAKVPLNEYQFPQKKIADVQKQLESLISKNHYLNTSARDGFRSYLQAYASYSLKKIFDVNKLDLAKVAKAFGFSVPPKVNISVGSVKAKKSADDSDDDEPPSKAHKGDGEIKKAYYRNRGHKKGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTI5</accession>
    <name>K1WTI5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTI5"/>
    <dbReference type="HOGENOM" id="CLU_1603913_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTI5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="166" mass="19201" checksum="17258757BB27F6D7" modified="2012-11-28" version="1">MTQERRPQFLQSFSCPTSPPDGNSHTRHDPRQPFKPPPSRAHVPLPSVAQVLQTLPALSTQDYKEYKRLQRVQIFPIYSARSGFQVQLPRSPLERARLSKSVKLQNGGNGYNRAIRWEEKGRKLRPLDWSLTQQGEEKWSGDWSMLKDRGMKRCEERGRSSSPDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTL1</accession>
    <name>K1WTL1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTL1"/>
    <dbReference type="HOGENOM" id="CLU_2028342_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTL1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="122" mass="13090" checksum="90F4E4B003BABFBB" modified="2012-11-28" version="1">MHAADRKPVNFAFSNSKFHRTQSQSQSVHSVTSPQQTLLPSLAPTLGSLLYASHGNGSHDRTLLRTRSALHPTTKTITTAPPPFPDHARLAFLSTAQLAYPLRASFPGTSDSAQAERPSVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUU1</accession>
    <name>K1WUU1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUU1"/>
    <dbReference type="STRING" id="1220162.K1WUU1"/>
    <dbReference type="eggNOG" id="ENOG502SFRC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1278426_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUU1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853089" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="216" mass="23639" checksum="8184D6574D827259" modified="2012-11-28" version="1">MFALIAALAVAAVPAFAAEEKATFTISPISAPELCLAVNNATNGSGLKLSKCTNGAGTAYTYSTKTAHLTAFTEEDLKGEEQDDAHHHCIDVTDGKAHNGNLLQHWICAIPSDNQVFDFDPVEGKEDKNIYTIKWSQNDYCFDVKDGNFTEGADVQIWRCVPSNTNQQWTVANIADPTCDGATDGSLETYAEEAQKLEAEQQHKRGLNGHRRRTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVI7</accession>
    <name>K1WVI7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVI7"/>
    <dbReference type="STRING" id="1220162.K1WVI7"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366458_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVI7"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="544"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="761" mass="85703" checksum="7059D586B38E1144" modified="2012-11-28" version="1">MSHASEDDLPTPSHRVCIHRDPRQQDLANGEWQNHPIELIVYDLDTRRHPDNNGSLVKSMRHILYDLGGKLPEDIKTSRGELVVSASPPHPGCLQKTVRITWAPGKWNQKVDLVRGMELVKNELEKLGHEVFWANAAASDCRTAVRFKTCLPDKGGVNNTPRWPFREREPVDWMGTFCPFELCDDVEITVVKGDFKTRYAGNTIEIQLKRPWMVDRMEDLAQTGQEWFERDYGLTGFHRSPAQIPITYPTMIASPGHLEFDVDGSLAELHRWVSAYNEAFHTNECLLKSEDGKEGVIVRYPKITNLVVTPSSLGLAQYLTQQKPRAGHPFEMLYELNGRFLLPKSEAEAAIEKEKHEAESKKIDTILRRLKRIQDHLGMSDSDDEPVERKRKRCYSDVETDSDEASAEPSEETAGGSRKRMFGSGRALALEPLVWPREEDDEGYMQALDDFNDQAERDSDAYGVHDMYNKHESPTNRTPLELNSATGHRQGGRCQSALSQPIRLSSVRGPGSSAFSDRHPCISPRWCGQLGSIEPTSPGIALSTMSITLHHLRASRSARIFWVLEELGLKYDVAVHDFGSPEWAELSPFAKVGADSGLGARAPVLTYNGKNLTESAPIILRLLADHPSSDVQSQPTEDDTFWSYFSEGSLMLYVQPSVFIKIGRKQISRDKSLGEDAQKGADAMEGWVQQWAAKNTKPGYEQAEKYLQEHEWFSGTDKPGLGDLPAISAWKKKIGQRPAYQRAMARMRDEEAKQKKAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1V061</accession>
    <name>K1V061_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V061"/>
    <dbReference type="STRING" id="1220162.K1V061"/>
    <dbReference type="HOGENOM" id="CLU_1107766_0_0_1"/>
    <dbReference type="InParanoid" id="K1V061"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27746" checksum="DC267784FD90DA6A" modified="2012-11-28" version="1">MPLNQVQHFQRHVLQQPLDRPLIPTGGRDPFSSETIYGLGLQSYLYKGVRILGHSGAMPGHAAQIYHSPERQVSVAVMVNDSEWSSQLLAIMYSVFEQVLGLDKADWGRMVFDRTAQTQLPPRVNGHGPAVMGKFCNKGYPMLDFKTPDAGIVESLPTFVSNVSASQAQLPKSIMSHSVILTAVDPPYYNWTLALSRYQPPLVGPRSTTGTAVVTDKGIGMFGYFATADVDMAEPTVQDVERKSEVWFKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1V068</accession>
    <name>K1V068_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V068"/>
    <dbReference type="STRING" id="1220162.K1V068"/>
    <dbReference type="eggNOG" id="KOG0536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361377_0_0_1"/>
    <dbReference type="InParanoid" id="K1V068"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="162"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="692"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="774" mass="83445" checksum="F10617F6D1F8335A" modified="2012-11-28" version="1">MSWPKPADDVEEDEEDLDKPPQFPLPGSAQRSAPAPSSESATPPAPALELAPPSPERQRSASPPSDLNIAILPDPIPLGNMAPPPSTTSRPAFGMKAGGGLGPPASAVTQNGGLGVPAAKPAVVKKEKKGRGKVALGPGCSALDWARLTQSGENLRGVEGGLIRVTKEELAKHKTHDDAWSAFNGAVYNITPYLRFHPGGEDELMRVAGRDGTKLFTTQSSRSVSVSRCQPPPHLRHDDVAGPPGRAIAFHLPAEPDALLALGQVNQRLHAISQAPILWVRLFSAAGYTLDPESVPKLVAARSPPGRWKGGKWLAGNGKEEGWSLWPSAWLGRLKRRRLPGAGTPPVKSQPPQSSPDTEDQIPVHWPTLFRSRQLAQEESEARGPHPLYNPARDASNPFHPSHFSRPSRPPSGNESEDEFDDSDAMVVYPKQLWQLRDHTAKIYSCAVRGRWLITGARDKCVNIYRLPKLPNDGSKPTAGPELVLREKVHGSSVLHLDFILDVNSIRGAAAEAGLDFPFSDGKNRGLLVTSATETVYTWDILWPSSNTPTVNENGEPIKPPAPRLRKRATLLGSEAPVSDVKLHGPWVCVMYVNGLCRVYSATAAGDAIPLRTVFGGEGCHLMALHAGRVLLAGDERTVEFDLHSGREMGRSKRNTAGRVTSMDWDGDHTALGTAHGTLELSRRLGRHTLVLNGSGQLVRRVLLDPGSNTLVSAGYEGRVAFWDLEAGEMRRAYDLQSGPIFGLAKDGMWLVVTTADRVIVVAYGTGLPYAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2Y9</accession>
    <name>K1V2Y9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF159 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2Y9"/>
    <dbReference type="STRING" id="1220162.K1V2Y9"/>
    <dbReference type="eggNOG" id="KOG2618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2Y9"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50451" checksum="6F3C59469788EE55" modified="2012-11-28" version="1">MCGRFALGQQHIDFLEALDAQYPRIFRRQPGGRAPQRLRGGGPHDEEKPDTKPDVKSEDAETKPSTDDAEVKDEKPQSEDLESSNAAGDESNAPNDQEEAEEDDEKPKVEDDAPERSKASEDLKWHAAPALGFKWKREQDFWPSDPSSGGLWHALKGRKRCVVPAQGYYEWQKKGSTKVAHFARLPLLKDQSEEHGIRAEDPPIVMFAGFWDEVEYESPVASKWQPAPGDEREPYPTGNPVPLATFTILTTVPAPDIAWLHDRMPCVLRSEEDIARWLDLGETPQGWVDGKGGTADVLQSEPGLDVYPVVPEVGKIGQSKHAYILPVAERKDGIKSFFAKQNSPVKPKAEPKATPKPTAEAKAETFVKAEPATPTTSKPKAEPTSEVKASQEKPASQESKPAASQEVTEVGDSEDEKPSKRKAERQGGRRTKVSRPVPEAKKDQKSITSFFKSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6Q5</accession>
    <name>K1V6Q5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6Q5"/>
    <dbReference type="HOGENOM" id="CLU_1284088_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6Q5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="215" mass="24882" checksum="0DEFE47A648F1775" modified="2012-11-28" version="1">MGTTARYLRYHRAPRCHWYWLDKLEERSPVPHLKYRGPVTPTATFTIKAPVWRLLEKKKLGFTHTIIRNGIPSRPFFRVIPWPVGRDPATFCVDDLLTRELWHGDEHPIPPPPPPFDSLRNEYQLQGEWDRHYGRFVESLLPSGLKFRVEVPVKGVDDLRLDCAIYTNAIGRHLTAEDIHSSMEEKSYAVLNDSMFDALDAFQAGGGEAWVYKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7K0</accession>
    <name>K1V7K0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000354">
        <property type="protein sequence ID" value="EKC99979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7K0"/>
    <dbReference type="HOGENOM" id="CLU_748391_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7K0"/>
    <dbReference type="OrthoDB" id="10656460at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40493" checksum="E25A60E5ED95B302" modified="2012-11-28" version="1">MPKKKLPKSHSNEQGNLQQPAEDSAPALPLRTNPNNATQLAHAQCSSPLYPPMTWYEGGTYSSPCTAGGDLDLPDRLPVNEAVLNQTDKSLNKQLWALYPVELSSEAAMEQGAALHLSALESFDPACVPLDELSRRLGWQAADQRLQMMILDNITLEDLEAVGVYNCGPKSRRHSNFVNQLKKGVSLLLAMPKKLHHVVSVEEALAKVNSMMDDRHQSEAAKTLQPPLIWGLELRAVLSDLLELAPWHPFPDVMTAEQAFATGLAQMYTGLLYECALLSYRLVTTTADSGFAPSNSRPCSSRLVTSPTASSLWLSSCTMSPTSPSLLEDMMATCPISTGLPDLTSSPRAISSREWKQRLPNPTRGRMRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8R6</accession>
    <name>K1V8R6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GLTSCR protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8R6"/>
    <dbReference type="STRING" id="1220162.K1V8R6"/>
    <dbReference type="eggNOG" id="ENOG502SBQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504513_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8R6"/>
    <dbReference type="OMA" id="ACHERYQ"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="54400" checksum="82D4EEB0FBA2B06B" modified="2012-11-28" version="1">MSTAASPSGPSTPTPFSPSTAPGSSAQTPNPHAQQRPRQPSTTASPAATPSQPNTPAAPAPQPLPTQAPPPPPEPDYAPITAVKRKRLQDTGYSPAEIAEVESRAAAFDLALALDQDAVLNPPKKPKAFTSFGDAVEQLLPYHVFQIHDDDLLTEDKRTPQQDALELTRQHASDLPSLITLLQASTQVVREEMQGVQAELRTVRQQWDVIDAENRRKRQAIEEAQRKEREAREAAERARQAEIRRQQLLVAERERLARLQQANALQQQQQQQAAAAAAAAPPATTPVPVAAAPGTPAPAVAPAGVGVPAGTPVATTTASPAPGTPTAVRGRPRGRPRGSGRGGVRPPVTPHIASPSTPGARPATPATTAAKQPVIITVAMATVQQFVNHGILVIPPVPGGPKPPASVVRTSEDKKQVILSIDLGACNQAQLQALARILGVHNKLPGASPGAVGAAPAAGTAGTSAPSTNAAAAGAAAGAAADAAAGGSNASTAQAGGGGVPTAPAAPNGPSVGAATPSNAAASGSVTPGTANAAGSGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9R6</accession>
    <name>K1V9R6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9R6"/>
    <dbReference type="STRING" id="1220162.K1V9R6"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="K1V9R6"/>
    <dbReference type="OMA" id="NVNEMFV"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="193" mass="21332" checksum="C1C121E7C5CD1E5F" modified="2012-11-28" version="1">MPRTVSNKLVLLDEFSDFRVQVVCDADAAFLLYAGAAFLTQTVKLDEATNVKFEIWDTAGQERYKSLAPIYFRNANAAIIVYDITQPPETSFDKAKAWVRELQRQADPNIVIMLVGNKLDLASQRKTPRELGQQFAQEEGLLFCEASAKSGEGVESMFMEIAKALPLNAPKPGQQGGVKVNPQQQEAQSACNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA03</accession>
    <name>K1VA03_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="11">PAGM</shortName>
            <ecNumber evidence="4 11">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_08165</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 11"/>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA03"/>
    <dbReference type="FunCoup" id="K1VA03">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VA03"/>
    <dbReference type="eggNOG" id="KOG2537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="InParanoid" id="K1VA03"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="18">
        <location>
            <begin position="195"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="17">
        <location>
            <begin position="311"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="15">
        <location>
            <begin position="465"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="510"/>
            <end position="514"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC97550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="553" mass="59018" checksum="3F7BC6FA24244C45" modified="2012-11-28" version="1">MSKPQDSSALFAAIREAADKYPKPDGVTFGYGTAGFRTLGSKLPSVLLRVALLAVLRSQRLNGLTIGVMVTASHNPEPDNGVKLVDPAGEMLEQSWEAYATLLANCSTTDELIAGYQQIAESLHINVTAPASVVYARDTRPSGPELVTALQTGLEAYGDIVKTNDLGVQTTPILHYVVKAVNDKTGEYGTPTVEGYYEKLATAFKTLIGNRKLEPLYVDCANGVGAIALQDFAKHCDVLPFKALNTDTEKPGALNYQCGADYVKTKQALPPSIAESGILTKPNTRAASFDGDADRIVYCYLRDGKTFRLLDGDKIAVLSALFIGDLVNLAKLGDKIQVGVVQTAYANGSSTKFIKSRNIPVSCTPTGVKHLHHAAQRYDVGVYFEANGHGTVLFSPEAVSTLKSAQPSSPDEANAIKYLLALGDLINQAVGDALSDLLLVEVVLAYRGFTATEWDSSYEDLPNRLVKVEVPDRSIFTTTDAERKLTSPAGLQARIDEACKKVDLGRSFVRPSGTEDCVRVYAEASTTSAADGLAVTVSELVKEAAANVAAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB10</accession>
    <name>K1VB10_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB10"/>
    <dbReference type="HOGENOM" id="CLU_957086_0_0_1"/>
    <dbReference type="InParanoid" id="K1VB10"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="32898" checksum="8B9B3646C99807C8" modified="2012-11-28" version="1">MASIIDDYHPDGPLGNFCLLPFVDEAEANLPPATHIPRHDKKRKARRRNHPEGRESKRRGREPASQSSVPEAPDLSMTSHQDEADRGLVAENDRLNGLVTRLQGQLTGYEQRQKKNTDRIRSLEKALQVQEAISHRHAQELVRRDGEERTISDQKGAGDREQVSKAQQQHGYSRKMQRAQPYDGHVKAEKVTPHLTMSHSDQVSVKIEPDADSPSPSDFDLARLSIHDKHPALETMERTRLSLATCIQDMSALPGQRLTHGDRDYRALCAVHYDVTLQIRQLERLCAKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBN0</accession>
    <name>K1VBN0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBN0"/>
    <dbReference type="HOGENOM" id="CLU_2656213_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBN0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="76" mass="8404" checksum="629ED50368CF8B67" modified="2012-11-28" version="1">MRPRPKPRMPNEDSTMTRSSSDRQLTQLGSNNPFNPHGTVRRAGGEARAPRVPPPKPVWVQFEDEWSSASSGSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBX8</accession>
    <name>K1VBX8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_04207</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBX8"/>
    <dbReference type="SMR" id="K1VBX8"/>
    <dbReference type="STRING" id="1220162.K1VBX8"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="InParanoid" id="K1VBX8"/>
    <dbReference type="OMA" id="PFGVGHM"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="14"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="269"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD01505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="396" mass="41137" checksum="C3D0558EA6522129" modified="2012-11-28" version="1">MGKAEIMRDSPDDVVIVAAKRTPMTKAKKGGLAKARYEDMLSQVLSATMKAGKVDPNLIEDVCVGTVRTPRGGASISRMAALAAGIPYTSSVSTCNRQCSSSLQAIWTISNEIRQGDIDVGIAAGCESMTHHYVPKPLDHPHSAVVASHQLASDCLIPMGLTNENVAEENGLSRKELDEFAASSYQKAERAQKAGKFEHEIIPVSIEGVTVSTDDGIRYGTTAESLSGLKPSFKENGTTHAGNASQITDGAAAVILARRSAAEKLGLPIIGKVVKVLSAGVPPRIMGVGPAVAVPKLLQKTGLTPDDIDVFEINEAFAGQALHCAREIGLDMHRLNPNGGAIALGHPLGATGARQVATGAAELQKRGGGLLVTSMCAGTGFGVAGLFEIKGGNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCC0</accession>
    <name>K1VCC0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000390">
        <property type="protein sequence ID" value="EKC98455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCC0"/>
    <dbReference type="FunCoup" id="K1VCC0">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VCC0"/>
    <dbReference type="eggNOG" id="KOG1302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016678_3_1_1"/>
    <dbReference type="InParanoid" id="K1VCC0"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="682" mass="73207" checksum="A181785BF9BEA073" modified="2012-11-28" version="1">MSTTQPQGQTPTIPASSLLRSDHRLLAAYNQPQQQTAMSSTAGPSRSTSAIHGTGSGIRSQGPGSNAPTSTMSSTAGDAPSSESGGPDFGVLKELGKAALVEVLNDIPGAKTLVLDSALAGPLGLVVDVASLKMFWLEPGPLSAPTRNVVYLTRPRRSHILLIAQQVRANPGLNYHVLCVPRSTELVRRVLEDEGVSGDVELGQFKLELIPVETDVLSMELDDVARDIFLRGDETPIFYSALALSTLQRAVGRIDRVIAKGDAAKLAGLIEKHRPAVEPSDSIDSIVIIDRAVDWVTPMCTQLTYEGMLDEFVGISHSHIEVDSQLLDPDAPAKKRKHHLSSADPVYASIRDLNFALVGQHLSRLARRLEGEYGGVKNLQSVSQMKDFVGRIGGLQSEQQALRLHTALAERLLPITRSDNFNKSLEAQQNLLAGYDAPAQWGLVEDLLAEQAPLMSVLRAAVLYSLTNGGVKPKPLEAFKRDLLQTYGYQHLSLLVALGRLGLLAKTPAGSAASFGSARKNLRLLVDDVDDAAPQDIAYVYSGYAPLSVRLVQVAAQRSALSESREKEGWFAATTQPQARTGVSRDVVRMEGKRPPTGWRGMEDVVNSIPGNSYDKGPSGSQARSTGTTLVFFLGGCTSTEISALRWMSKLGGRRFVVATTGVVNGSTMLESFGDPKPVPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCM2</accession>
    <name>K1VCM2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCM2"/>
    <dbReference type="STRING" id="1220162.K1VCM2"/>
    <dbReference type="eggNOG" id="ENOG502R38G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395974_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCM2"/>
    <dbReference type="OMA" id="LASSECH"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="709" mass="74486" checksum="332A762DECA4E745" modified="2012-11-28" version="1">MASVARRPQECASMYSPLDQLVKGAGVGVGGGAPSTISSSPSSAAPDSTDADKPIPALDFNLFRSPSIYSVDSGLETISLASSECHSPYTGPIDLASDSESDERCYTDGESSEDDYMAVDERPTSPSTPRAKRTASGDTLRGSPGSPTHTRSTTPTRQGLSHNMPYAHAGAIRSALTDSSFALKGVPSVRNGRSHSASSDEVQPSAAAAMAAVVATNRSASVPVRPQEAIQPHLVGQPSHIADDAASVHGEQGSDWGDDENGFEWLDANTPESTNGDAKRYSSSSNVNGRTSRLRVAINQPTGSGSLSPVPSEGSKESDESPTTPVATAPGSSLLRAPQLTPNNSSQASLNSSSTKKKRPIVIPRRAAPPPPPGAPENLDIPLTRSRSPRSPRGIPTSPGPPVQPRPRASTPEEVPPVVVTSASPSPHRGGDSSSIGIGRPNGRQTNLVSVYELGDASSSSDTLRGGRYAKVPLPAEAPLRGKKMGSPVSMSDMASEHRRREPRRHASSAMLSSRSSKRGSSEEDLDLVSQAKRHRDKGDLPKAAWLFMKAAEQGSATGLIHYAIALRHGLGVARDERKAFAELVHACDVGLKESPVDLRAAKTSNVIITPAQRRQLLPDLSLGLTEVANCYLEGSGVKKDKNSGLEYLRLAGTTGDLGAQEQLGEILSRGIGGVKKDVKEAAKWYRAAIQGGSNVPGLAWVWKEKYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCP6</accession>
    <name>K1VCP6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCP6"/>
    <dbReference type="STRING" id="1220162.K1VCP6"/>
    <dbReference type="eggNOG" id="KOG4365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714084_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCP6"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="328" mass="36442" checksum="83721E7F7C2D406E" modified="2012-11-28" version="1">MNEPTVVKRLHISGLTPQITQDHLRDRFKSFGTVLDLEVPGPNAFGEPRAFVYLNIETTPAQLRKCLNIMSGAHWRGAQLRLAEAKPRWDVKYASGSASSSKVDEAKRARHAAGDRAAGQVLEDREWPPRPADLYAVLPRRVIDPERWGAAHEVFPELDVEREDGWEFESADEEEEDDEGRVLLGHWRRGEESSPVYGRVQPSAEDLYATEESESEYDAGSRASSPMFPARDGSASPLFPNRDRLASPLFPSRADRERSASPLFPSRREERERSASSLFPSRAADGEREPSSPSEGAADAGSDRSVSPLFPTRMPRSGSSSPLFPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD28</accession>
    <name>K1VD28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD28"/>
    <dbReference type="HOGENOM" id="CLU_1714614_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD28"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854086" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="153" mass="16676" checksum="30A6961D36EF1CF3" modified="2012-11-28" version="1">MFTLLIALTAASSALGQALPQNGPIKRQGANVCLDNTWGDLTDGNQIQVYECFDTAPNQQWTWEPSRKVNNEQFFHLKFGDKCVGFQIPSTGNAAGAHVAIAPCDSDKWQLDWRWAGENICSTGNRCMEVGKGNNDKVTIGSCPTPFVVPDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE21</accession>
    <name>K1VE21_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE21"/>
    <dbReference type="STRING" id="1220162.K1VE21"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="InParanoid" id="K1VE21"/>
    <dbReference type="OMA" id="MWGCPFV"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001990">
        <property type="entry name" value="Ras family, other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="222" mass="24800" checksum="8D07637E20FE30CC" modified="2012-11-28" version="1">MSQASRMVFKITVLGDGGVGKTALTVQFTMSSFVETYDPTIEDCYRKQWVVDDQPCLLEVLDTAGQEEYTALRDQWIRDGEGFLVVYSIASRSTFDRVEKIVERVLLVKDEASYNATDSAGYPHGHGNGQHTTRTPIVIVGNKRDQYNDREVSTEEGRLLAMNLGCEFFETSARLNQNVEAAFKALVRQIKVAKSGPEYAHGQQGHGHPPTKSKKHKKCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE55</accession>
    <name>K1VE55_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000413">
        <property type="protein sequence ID" value="EKC97331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VE55"/>
    <dbReference type="eggNOG" id="ENOG502S3MD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241907_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE55"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1398"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1668" mass="179130" checksum="D9924C340986E94F" modified="2012-11-28" version="1">MTTVVQPSPAGFGSSHGHVPTHSHSQYPQQQQLQNSQQSQPAKHPRPPLPQPPQPPQHAQSPSQPPHPYGSQHGTQQFVPYTTPQTSASNLATITESAPPSAGTTPRTAAQASFPDLTPAPSHAPSAAASTEELAALEFAHETGTPATGLYSQNGLWSDDSDEEEQRMSWRQRLSNSTAGDRRSVKSSKSNGGHSHRGSRSKMDSIISPLSVESPWPWSRKSVAERRESPPANEQQEVLAGDNPVRGGSGNRHSGRMSPSTSISSCPQPHPGKHQHTASMHSISSQHSTVSAASVASNDLSLKQRISMGRLRRKSTSKGGFNDFPDVVPAVPQIPAALESTLSIRSQKTNSRGSLPGTAGDGKKDLKASASTKADHVNVSVIPTSSSSSSLKALAAEARVHAASPSAHSPRPSASSITTPRQQPQPLPSPSPTPTRTMPQPVPMPTPTPTQAVPVPRVPPQAQAPASNRLSITTQPKKEEKDRPKSFIKRNVERLWRSKSAHGLHENYDGLEPSSPPPVPELPSKLRKPPTSTSQQAAGGRATPANPAATLGRISSPVANPIAASAIFPMAPGTTGAAPMSPVATGHSTNSAQTGNFATISGLPSSGPAGDELAAHLAALDAKYPSFSASTLGGAAGKSTRSFNLIDPDEALETDPFASAFEPPRRPLSRVMSRTSTRTSARDSTRDSMLTLDEDVPRPWTPGLNSPSMRSLMPRLYKSKSFASSSRPSSMAMFFSKDKDRDSKPPPTPDLPTHTIVNSPVPTVPSAASDVPSPRPTPSRSPLHITDTEVEEKANAAEETPVFYDSFDVPPSEDEEPRSRCGSVTRGEIAKVSRAFPAPPTTFVDELERLEPASQQQQQPATAVQGSEQEAQAIEQSRIVGPPRGSSSGSVSGVTGGVIDGGVGGSPRQDHVPFPGPSLNRDRDVIHHHHHRISSHRHSNNSSDDDIDNDLAPRHSASVSGSSLELRTPHPNTHPDSFAAHPILKDRDHPDSRDHHQDDIPPRPESANSFQQLYDQLDINPNTLQPIHPLGPAADDASFCDPFGLSHPGSAFSYKAPQVASTSQQSPGRAVPAVPFPEVENSPRLHSSEDYAFPIDIPSQPSSCTACDPDLATTPNKLKRMAVDYSLQRKGFNPHAAAEPEPSHGLGVQLPQRSSSRREPHRHTSEGRHEHREAYQRLGSGMPSPGAGASRSRRESNEPRQRVRSGPEQWIDDMDTSSSENEQDETPLSQLHPAAAQQQQERRARSLARREARRAERERQLRCHKQNQHSDGTLRPAAHWNGEGGVPADVLAGRLENVAISNANGGLAAPLRSQRSLRRPHRSSDQSPSPALSRATTMSSRPSRPSSARPLPNPSDHGNHASSSHSQAPAQGQSRPASGASAAQHRSRQRSHSIGARHPPPSGDVPPLPRGRALPVRCIVVADEIRQISIDVYHDTIAREILSQLKGKLPAPTANAAWVVCEVFTERGLERQVRDYENIASLVKGWDASAANCLAIRESALTLARQVPESAPFVGGWCQLEVKPGKWSKRWLETRGGQVFLSKNDKGKDEVQLNTLFSDVYRPQQSYGAPQPFVFAIKRLEPSASFERPDEFLFTIASDESTGYKLHTAVYSSRSFTIGTGNPAAMAPKTKSLGRSKSMAQRRPEQTLLDVHNTPSAFTGKGLLKHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE60</accession>
    <name>K1VE60_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE60"/>
    <dbReference type="FunCoup" id="K1VE60">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VE60"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_1_1_1"/>
    <dbReference type="InParanoid" id="K1VE60"/>
    <dbReference type="OMA" id="VQTNIVI"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="110"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="490" mass="52261" checksum="B4626F0F7EE6E32A" modified="2012-11-28" version="1">MSTASSSRPSIPSTTNPSAGYGTPLSSLLLPNFKPKQVKPSHAFNSYTGFTKSVTPSTASPASSAASSPKMTASLPPPSKLDEGHPCVTDISEAIGGKANVERLHRTARDFRSDTFTMPSDAQMMEGVRASRGDDVYMEDSATAALEERIAKMAGKEAALLGVSGTMTNQLAIRTHMKQPPHSIITDNRAHVHLMEAGGIAVFSQATTHALAPSNGLHLTVEDIEPALQLGTNIHIAPTKLICLENTLSGIVFPQDEVVRIGELAKKHGVAMHLDGARAWNVAAAELERRGLDPNSEEDRTTVLSDILAPFDTASLCLSKGVGAPIGSAIVGSKEFIERAKWFRKMFGGGWRQSGSLAAQADYALTHHFPRLAGTHALARRLADGLKEAGCDIVAPVDTNMVFFDPAPAGINLEQVAAALAELPDPITIGANRLVLHHQTSPQAVEDFIQVVKDLADAVDPEDRPTKRQKLGEKDGRIRLQVTGNYTTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEB1</accession>
    <name>K1VEB1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEB1"/>
    <dbReference type="STRING" id="1220162.K1VEB1"/>
    <dbReference type="eggNOG" id="ENOG502SAA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502652_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEB1"/>
    <dbReference type="OMA" id="FVNAFTH"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851802" description="AMP-dependent synthetase/ligase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="57044" checksum="045F00C10A807AC3" modified="2012-11-28" version="1">MNIDNTTLVLLGIFLALMFWQRMKPQSLVHPLMLGKQAEPGPVRKTGESAIYRSWATGHNAPLTTQLQLRPSGQAKTVPDMIPKDKGRPESRQLLGAELDSAGLSQTATMLPGGLRELFPDLARATKDSPAPIAALIPPSTATGLPLLLLSLASRPSTPLVVVPRPSALPAALKGQGMPQAPKLVVLHVASLDRLPEIECSVLLVGDPQKNAAPRVGDRKNVQWWEDVWAAAEVVPNYTEEVSYIDTHSYWYNETGTDVAKAMHVNMTAGVASLLAIFPAEKRPGPKDTIASSQSLNTPFGMGIALAAVLSGSSIKLVGSPEPVWGASNPAADMIALAASTGPRPTILILTPAQEAAVLAGLYDTYAKTPFSSLAGRHMLRNLSGGHVSREGVWNTLVWSSVRASVGGLAADARANIVVGPVPESLLTPAAALFSLPLIRVTSSQWASGPLTATHFYDLQSPGGEIALPRPGGPIASAGPPANNVELLLKGVAEPWPETGKVAGHVWARGPSVLDILGVTGSDGWVDTGYEGGVLPNGTFVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VED1</accession>
    <name>K1VED1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000289">
        <property type="protein sequence ID" value="EKD02365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VED1"/>
    <dbReference type="FunCoup" id="K1VED1">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VED1"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_3_1_1"/>
    <dbReference type="InParanoid" id="K1VED1"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050085">
        <property type="entry name" value="AGPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338:SF10">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="474" mass="51933" checksum="AA23B0A7F7B13C30" modified="2012-11-28" version="1">MTKFLPSRNAILNKTVDNVFDSIKKDHKRLFWTAPADDENRAWHFERADGSFTRAGRSLYWYGVPDVKQVEKIIEGFEQNGRIDRVFLPVGPSTPPHRLAGAPANARAFSTSARPSLRAGAAEQRRGYATEAPRKRVALIGARGYTGQNLVDLINNHPHLDLTHVSSRELNGLPLKGYTKSDVKYSNLSPEDVGKMAENNEVDAWVMALPNGVCKPFVDAIDAAKAKGGKSAIVDLSADYRFEPSWTYSLPELYGRDAARASDRISNPGCYATNTQMLLAPLLPYLDAQRPPTVFGVSGYSGAGTKSGEKDADGHPKTVPKISQQDLEGSVRPYSLTDHIHERESSQQLQRLNGQEDFQLSFIPTVAPWFSGIVSVLNAPLAKSMRASDIVGLYEEKYANEPLVQITQQAPDVRDIAGRHGWRVGGVQVHSSGKRVVVVGALDNLLKGAATQCLQNLNLALGYDELAGVPQDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFR3</accession>
    <name>K1VFR3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VFR3">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFR3"/>
    <dbReference type="eggNOG" id="KOG1837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001128_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFR3"/>
    <dbReference type="OMA" id="AHASCAD"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="708"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="BP28 C-terminal" evidence="11">
        <location>
            <begin position="1574"/>
            <end position="1721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1852" mass="198813" checksum="8EF2EBF0060B83CD" modified="2012-11-28" version="1">MNAETTLQVFLPYHDSPNFARILAILNLPTDSPYHVPFAPLAKKAQPVAREYITSAISSARDPSLRLLTDLAESLKTAHTEGCTHRALLAFWSATLVDLLERSRSTGRVPEGVVKILVEAFVTLLSTPGVSAEVNAAVYPPLVLLARSVRLADAPFAAILEALLTPSTGAAPSQRVLTLLVLLDARKGWDQGLGADAPARLATIPQLGDLLVAAMEKYSFENAMQVIMSVLIDDVPESLDTLTKLVDYPSLPESVVKVAAEKLLNTPSGAHKDARDLLSTLRQRYPSLIDGAVLEASATSDVDPALIQWSSAETAFLDVHSADVASRVSGVREMYAVAEAAGLNRGNAAALIASDDKLRSAQNAIVARLRDIDVEVLSAVYAEPELLLSLLTGVDYIDAVLSTFNAIKPQPKVVGQHVAFLANTYIPAHPDVESRVFEKLLIPNLLATEDRRAFGPEQWPSVVKACRLAAHTKIPALDASVDQLVKFNQDLVKAIANAIASSGNIGSRVDLLVSALSASGASARLFAAVTLGQLVTCAGGYQHGVAARSLDALQASLGGKALVDVDTVESSLSEPLVKAIVTKPNQVRTMQRASLALLSAAASVRSSPNENVTWLGDDSSTESTEAQTRRVAHSLYRWANSASLSASVARNLLQSVLSQLGEDALIFFASVWTDATDSGLRVAALRHAAAFIKAYQGADKKKTDFQLIVPALLIALQDTSKEVRAAAAAILKSISESPASGSSDIYGLETIYGQRSDLVQLLKPSDLTKYLEALTEALDDMVLDASRLALVHGAALDASTKDGKKHVSQRRAVMDSLMSHVLGWRADDARRSLLSSLIRVTNASRLQGALPLLEPLTDVTKDEADWLASLPAAHKNEYLDLLFESFNPRHASVVTENDSEAWRFLLDLFSAKPTPIVNLMRALSLQRMADGLFLALKPTQRAEYIVDLVQSLHGLSAEDKIAAKAVLAKLRLSTLEIMGVVETLVEPLESTIQRKKAKSDDAEDKIEQAVYSITTFIESRDWKSLRGDASLVAALMSILSAVLTKRQSIKEGVDYLEQEVLGAILAQLEKINDASEILRARVGIEAIVKVIRASSNPRTSQRALLVASELARLVPESVLHNVMPIFTFMGSSDLQRDDAYSFGVVEQTVSRIVPVMAESLKEKATSTLELYTEARTFLNIFTDMAGPGRLPKHRILPFFVHLVKSLGAESFLAPVCMLLATGKKMPGLDLPLSVAQAFPAGVRTHTLLEIEREATRLVSGNDVGFLADEKHGARNAATLLELCAGLGKQLRGKACPQPAVEEVVRDLVSLSAEQLDSDDQLAESLEAALSNAMQLLSVPSFLSIIEKILESGREEDITRSLDMFTERLPLVKPEVRSKSSAAMGKIIKSAASLLKAGQVIAEHALIALEAVTASALPNEDGALASIVPTAIDAVKGADAETSVSAMSLVASLVRRLGPRSIPFIQPVLDACLSMASQTGAAIDAAFLTISALVDTVPTFISGKQLVSLLRATAEHRAEDEGASAVLISAVAKRIPTKTLVPVVMDLWKELKGAGQAPIEAFFALLKHALRHADRAALPALTKPLFAFFLDVFDLRHGSKLPAAAIDAVETSAIASFIELVTKLSEASFKPLFVRLYDWAVVDLSAPVNDAHVVARRTVLFRVMSGLLDKFRHLLTGYMGTLLPLVDELLAAYSNGEIADAGLWALMLDTLAKSFDVDEGAFWTDASLLKLLPGLVAQLSTLPELASSDVSPPARAIAALAAATNGETTLKKVNMAVCMTTRAEEPRTRMAALRALDAMWERHADEMIPLVPETVAEFLAELLEDENSEVEGLARKVLARIEGVTGSLKEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFW3</accession>
    <name>K1VFW3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFW3"/>
    <dbReference type="FunCoup" id="K1VFW3">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFW3"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="InParanoid" id="K1VFW3"/>
    <dbReference type="OMA" id="EMRICKI"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000126">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="90"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="263" mass="28296" checksum="C3F7E02AFA432F77" modified="2012-11-28" version="1">MAEGEHDPFQGQGEEDEEDYELAGPMVVAKLEEYGISKQDCEKLAKEGLHTIEAVAFTPKKMLATIKGISEAKADKILAEATEIHSRRSELVHITTGSVGLDTILGGGIETGSITELFGKSQICHTLAVTCQLPVHLGGGEGKCLFIDTEGTFRPVRMLAVAERYGLNGEEVLDNIAYARAYNADHQMQLLVQASAMMAESSGRGELAARQMHLAKFLRTLMRLADEVVAQVDGGQFAVADAKKPIGGNIIPNGIGDPEEMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG41</accession>
    <name>K1VG41_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NUA/TPR/MLP1-2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG41"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252572_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG41"/>
    <dbReference type="OMA" id="FAHEMES"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="6">
        <location>
            <begin position="431"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="949"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1115"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="152"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="375"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="607"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="747"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="868"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1040"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1182"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1272"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1288"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1305" mass="140835" checksum="52990B1D1BA3979B" modified="2012-11-28" version="1">MTESELATASVQCPTPEVQSATFQSAQPATPVVFPQHQKTITMAEGAPTDAAAPAAAATPTSAAQLPGDLLADVEREHALADLQASLKASEERIEKLSADNKTLETERDGAVSTSNQLRSQLASLQSAHLQSSSEMSVIQSRIDLYTLRTQKSEASQKIAQLDVEVSELKMSADSAKSLTNARNEILNLNKASTEIESRFNMYRAQTNENQTLQDNVSTHQSRLESLQRSFAEHTRRLGEAQTTIANLKTSAASQHTSFRLELERLEEENRILVKRSEDRDAAIADREAELEHQAATFSQKEAAWQEKLHRAEEARQAAEKRADDFKITVERLALAGGDGRHDISPAASLAARQRESGKSYTQFFTDYTIMETKLREVEAENVRLTDLLTEISQDLAEKAAEHDAAIERANALAAELASAHASRDAYESRAKALEANKKHDEEELLALRSQTEDLSRQVQGLLREIAIRDDPNLAHVGLDDNAKISEGDLITDKLTEFKSLRALQQQNQKLLKLTRGLVAKLEARDVRRATADASDIDTAASLDEAAETIEKLHSKLLDSEKKINELARERDFFSKLLSRGEGLRWSNGATATKNPLAGDTDNEVALSNLQAELDIVRSKADQEIAEAKEQARQKAEAAGVAEVEKVKAEAKAQMLEEQQRILSETHQLQQQANTTLEAQVRQLQGQISQTQLERRNALEQVAQHQAQETRLRDEAALLRAEKEQWESIQSRLQSDFSTVQQERVRLQHLIDNLSNVSTENEKTKNEQRTMLEKRIEELQREAGILRSQVDQAREAARAAEQKASEADARIVSETASIRSEKEAAEAQVTAKATEIETLQSQLADAKRIGLNWQRRSRDLQTQLTEASSNSSTAVQEKEKEVEALKAELETAKSKITELEGKISAAEQASSLKDGTITRLQGELEAAKASQGAEASTAAVDTDALKERDELQQKLSQAEKDLEAAKSAQPAEGSGDNSEIATKLAEAEKKLAESDAKYERDVLRVNRANVGLKKGKGEADARVNELQAELEDAKKKLEEAQAAASSGGDGSAPDQATIDAAVKAAVEKRESELKAEHDAAIEKVKNEAGPDADAVQKAVAAKEAELKEKFSKELEEAKKTAAAEAGGSGGDAEAAAAKVTELEAKVKDLSRQLRNADISRKTLERTKATLEAKVKALGGEGAATPTGSPTTPTATPALSATATAFKPGAKPAAKPAAAATPATPATPAAAAATPAAPAAAPAAAATPAKAEETTPATTTAPARGTSVRGRARGTAIRGRGAAPGRTTSVLNGKSLNVPQLQCPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGA5</accession>
    <name>K1VGA5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGA5"/>
    <dbReference type="FunCoup" id="K1VGA5">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGA5"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003224_2_1_1"/>
    <dbReference type="InParanoid" id="K1VGA5"/>
    <dbReference type="OMA" id="AHWISAT"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118955" checksum="D9E80374532BB59F" modified="2012-11-28" version="1">MSANDPNLSDAEKRLARLGGSVSQEPRAASPQTPSEEQAQSGSSTPHVPPSSGSRLLSQAIPSPARVPSPAAKPAAPPAPKPTPAPATPKASPSPKPTAPSGPSRSSSTSTPVQSKPRPAASSPVKPTQSYADWEAQAVGKVFNVTLDAEASDWKKTWLKELRSEMQEENPGMCAELCTGLSQLTDSLHANGVPRVARPSTDRSDDPDQLTVLAGMPEGETVFEYLTGCWKRLNGVNREMSRLGYSKEEKAKWHEAYNELKRLIISYSGMTLEDPTIKPVGPAEFLPLLLGVSGTGAAGDPLTSSAPQPVVQRNPNALAPADLLPFLNDLATGFPEGGMADVITPTLSLFFQEWFKITPTPDLLGQDWQKYLGAMTLLVQVKAIAAIPQIWKTYFSNPTERKTADIDANKSNLRHGLGALQNGLFTLYNAIVRASPESREGALDFFAKVVSLNVKRAGSHIDKVDPEYYRHSKRLDVSEETKIHAEKAEADEYFGQAMDTDSKPGFIPDIFYLLNHVHHLGTIKTISTRTKLERNISDIEKELKRLEGMRGQWAGNPTAEAQGEAAIKKYKGDLATIHASIHAYDTQLLDPAMVRLNVSFCGFLMNWLLRMVDPDHAHPQKPIAWVAHWISATDNCSLPLSSESPVQFRMLPEFFFENVVEYYDFLARYSPDALDDADKDILITFAIAFVNPTHVNNPFLKAKLVAALANGLYPVGYWRKGPLFDRLSTHPQSTAHLMPMILRFWIDVESTGGHTQFWVHVDESAAPDNLDQFIKFVNMLMSDTTFHLEESLTNLAAVHSLRAEKEDEESWNAKTQAEKDDTESQLRQAEQQAPYHTHMGLDHIELIRDITATEKEPFLVGEIVDRLTASLDESLATLVGPKMQELKLKDPERFGFKPKQLLAALAQIYLNLGSEQDFIRAVANDGRSYSKEVFERFARILKNRAIMTDGEVQEIVAFTQRVEDAKATIEIEDEREIPDEFLGEFEKSSPKLTIPDPLLATLMKDPVILPVSRVTVDRSTIRAALLSKELDPFNNVPLKYEDVIPNDELKAQIDEWIAQGKVAKPQEVKMDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGB7</accession>
    <name>K1VGB7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGB7"/>
    <dbReference type="STRING" id="1220162.K1VGB7"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_3_1"/>
    <dbReference type="InParanoid" id="K1VGB7"/>
    <dbReference type="OMA" id="IMKGSRH"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF13">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="534"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="760"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113512" checksum="CA93B6F3BF7C06C9" modified="2012-11-28" version="1">MTAAASGQRQEAVKRRTWRRVCKQINLTFLHRHREPTHDKSLHHAAPSTLLRAPRLNPARLCRPGFSYYDPARRRVIHTSDSSRSFAAAVATPPEYDVIATYPQRPPHHPSSHSPSLTASIHSDAAAAALVVDGSDDTELADAFFDHAPEEGTHPRSFDDHLPPAPSEEHPTYEDAMKKPRRRTRTLESTSPFDPPPIDGPSRFDWRDRRRPKFDTHGLPTWQKWWYPETPRVMPKMTKMNETEGGWAELRRYSDHFVPLLLAEQAEAETQLENRLASWSDHQLRSEGFMINGLAGSTEWQPRYKVHGVVVSFSRWGSDGTKPLPPSQFEPGATVILSRTHPCQDAFEIEGERVKGSVFTISRGVVRVLFPELPNDVELGSWRIDLGVSDFAIQKQREAIDRLNLDPVLQDQQSLPAAPSDQDPEDEALAVTMRRQRPQEILVGTGLRDLILRRFQSHYEPLPAPGSGKLDEIAAQVADMKPEDMEASTGIDHDDYSPRGILSANKLIDSWARRYRVPEGTVPIAIEGDPRVPLNPSQTRAIAMMLSERLSLVQGPPGTGKTRVIVETIKLLKQHWQIPHPVLVCAHTNVAVDNLVEGLKTQGVNAVRFGSPDRVSPRVEAHTLEARIEQHPAYPVLNRARNSKESLQAELSENLAGPQREAKQKEIGKLNGRIYLLKRRLQAEVLHEADVVCTTCLSATSRVLEVIDFPFVFLDEASMATEPLSIVPLTKGSAQVAIIGDHKQLPPVIVSEAAQQGGLGTSLFERLIHEQAVPSIMLDTQYRMHPSIAAFSSEAFYNGQLKDGTVVDGQVDPVLHPPTTAFLLPDGDSSKSLTFLNHDFPESPQNRSIANHHEAGRVCDIVADLLASNPDLKGADIGVIAPYSAQIRLITEFLTIDERRQRAFRQWLGPERAREIEDIEIRTVDGFEGREKSVIIFSTVRSNTGGFLGFLGDWRRLNVGLTRAKRALIMLGSLRTLSNGVPSATALEKKGIPIDGTRVWKRFVAWLRKNGLVMEDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHN3</accession>
    <name>K1VHN3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHN3"/>
    <dbReference type="FunCoup" id="K1VHN3">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHN3"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="K1VHN3"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000711">
        <property type="entry name" value="Probable cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="294" mass="33253" checksum="C9365657EA1C57FC" modified="2012-11-28" version="1">MSLENYTKLEKGSGTYGVVYKARNVHDGSIVALKKIRLEAEDEGVPSTSIREISILKELSKDDNIVKLFDIVHSDAKLYLVFEFLDLDLKRYMDSIGDKGEGLGPNMVKKFCYQLIKGLYYCHAHRVLHRDLKPQNLLIDKEGNLKIADFGLARAFGIPLRTYTHEVVTLWYRAPEVLLGSRHYSTAVDMWSVGCIFAEMAMRQPLFPGDSEIDEIFRIFRLLGTPDDETWPGVSSLPDYKASFPKWHGVDLNKTIKGLDADGVDLLAQTLIYDPAHRISAKRALQHPYFAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHN6</accession>
    <name>K1VHN6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHN6"/>
    <dbReference type="HOGENOM" id="CLU_716088_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHN6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="386" mass="42158" checksum="5E1C2D88BD2756F0" modified="2012-11-28" version="1">MAASTSSNATCVFDDTFHRVTDPNYNWTRARDEYTDGWSDKTAQLRRLFSVRVGDSEVSIPGCFYLGTLNSTKAKERENGGGSAVLSTQTHEIADADVWFCALRNQVVKAADSAPKPPTDEDIRYMQNNISSRPALTCNMPTRAVLLHTSSSYDMNQAPPVGVSGDGQIRDGLLVALPQFGSRVFGYLAVRRTSRHYTTERCIVTLPLSLFLPISKTSAMAYMNSTNSTCVFDNALHRVTDPSYNWTRANEEYRDGARNEALARLLATSVGKSAVRLPGCFYLGTMDETAVQECEKGGGMALLISITKRLLDADVWFCGIPGESALIQAPNPATDTDLNKIQMYVPGNPIICNLPSQNAASHRASFSQWMPLIAIGITSLVVLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHU8</accession>
    <name>K1VHU8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHU8"/>
    <dbReference type="HOGENOM" id="CLU_307406_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHU8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="962" mass="103898" checksum="34303388217A02F4" modified="2012-11-28" version="1">MEFSLDPLPTFERAAPAPLDYPESEHEVDSLGLSRTSQASLYSQYSSRASLPSVPASREDPQSTAFWGNFGVSSVNLDQDLSDMTAPLNIVKRERALSEHRLSDRRGGDRSGELSAASLPNATNHPSAIYETELSIPDIFLDPGISPAEPSPVSQRTIARKSVVPSHCVSVPHSPTTSAGDHGYPNEIPDYYRGGRKISLQFRDSVPPVPSRDSSPGEEENALLKYPPFPEDADPHSGDELLSPTEWGVEPPEMRRDSGHSSDGGMVPATPKLAAARSPPARPPRPPPNLCPPVNGLPLPHLPEEQSRRDDNLNSGLAGSQKRDLLSPSVSPPPPSERVDVRRHSGYSARDSGSDFSYRYKATSPAGSGGYDDVDSETGSKWRPSKELGSTQRQRDPTLPPSPTKSLAPPAVRKLKPRSPLAKDGQEEDETCLFSDTDEDDDFGPGLRSRARSAASSARRRSSMPESPVPFDIPSKAASILGLGDSAPESGKKKKSGGILGDIGSKRLLSRRRTAGSSSASTLRGHMRKLSEFDPIGFVKGDTREAHIDRNGDLWVNVSAEAKKRPESTRTTRTRSDSDKGLPALPQTPNEVDVAEQVELYHAVKSRALPPTPESPNSARPRTTTPSGRTTPIAATTKRARPGSMFLSRSASQSLRRTGSQASSIKAASVAVPPPIRESPPRAPPRGPLPPPPHSPPGSPRQVTSPIPGSAGHKRSASSSSGATSLAHVKPTRDTLIPYFPPEEQLIRYVSPSRPLSHAQGRRTRALARTPSQSQTMYEGSRAPQHGISDSMRDELIAALQHGNLTPEQSALLEATFAALFSRPPAPRPSAPEPGRQRPDEMVFPAPPPRTSGELLRPENALPDVDTEEDEPPRPASVPPPRPPRRSVRRHSRSMNRLNVPLETHSDESGLESARDDRSEIDPAPASAAAVQSEVSEWEPDTPATKTRFPDFMKRLNKKDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHX9</accession>
    <name>K1VHX9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHX9"/>
    <dbReference type="STRING" id="1220162.K1VHX9"/>
    <dbReference type="eggNOG" id="ENOG502QUH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039854_1_0_1"/>
    <dbReference type="InParanoid" id="K1VHX9"/>
    <dbReference type="OMA" id="FFNAWMS"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="97"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="423" mass="46287" checksum="A1FE941D1AD0599D" modified="2012-11-28" version="1">MTVPSSSQLKPIDVGLMGTGEYTTGITPGGQSKSDKKIGVVGVTMFDLRRRGKVGSVLMAGTNGSKFPQVREHFARNVASVYKGLDCDFRSFPDEGKVDAEAYKSAISELSPGSAVIIFTPDSTHYAIAKEALEAGMHVLVTKPATQKLSEHQALAKLAEEKGLVCFVEHHKRFDPAYADARARAKNLGDFGFFSSYMSQPKLQLETFKAWAGIDSDISYYLNSHHVDIHCWIVNGRFRPVRVTASAAAGVAKDMGCDPRTEDTITLLVDWVSNTDESKRGTGVYTASWAAPLKAGVHSEQRFHYMASKGEVRVDQAHRGYSVTEDDTGKADYNVSYMKYSPDEDGFFDSQKGYGYVSFEKFIDACRRVNAGQDKAADFEGKGLPTIQDTVVTTAILNAGRISLDEKRPVEIVTGKDGELQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI12</accession>
    <name>K1VI12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar protein, component of the small subunit (SSU) processome, Utp14p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI12"/>
    <dbReference type="STRING" id="1220162.K1VI12"/>
    <dbReference type="eggNOG" id="KOG2172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821795_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI12"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="35494" checksum="D70BC0DD0835DF11" modified="2012-11-28" version="1">MFGDDSDSGSDSDEAEVLKLGEGRMVFGRAAGDDKPAKAKPAAPAANGSATKARSRSPSPAVGVFGDVNPWLDGTNSGPSRKRNKLTATAETKAVGKLKKAAQVKGDDEVEISLAAPKASKATMKAEKVVPPPKAAEAKAPKSILKVKSDVSTEQAKAATSNKRRAADSDSDSDSDADLLPVAGNGPKAFTQRELVAEAFAGDNVVEDFAREKAALIEADAPQTVDTSLPGWGSWGGKGTKKRKTNPKFLKKTAGVAAEDRKDAGRANVIITEKKDKKAARFLPTDLPYPYTSVAQYEAAMAANIGSEFNSRAAFQRGTLPRVTKKPGAIVEPIRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI26</accession>
    <name>K1VI26_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI26"/>
    <dbReference type="STRING" id="1220162.K1VI26"/>
    <dbReference type="eggNOG" id="ENOG502RYKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281067_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI26"/>
    <dbReference type="OrthoDB" id="5593376at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35310">
        <property type="entry name" value="CELL WALL INTEGRITY/STRESS RESPONSE COMPONENT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35310:SF1">
        <property type="entry name" value="CELL WALL INTEGRITY_STRESS RESPONSE COMPONENT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1122" mass="119050" checksum="F7026322684CAA57" modified="2012-11-28" version="1">MPPIQRRPSTARTHRRQVSRQLLTPLPSLDSLVASVSSTANPPNISAFTHPLGHNPPFGSVHHDNAIYPDVPYQLDDPGASCAVKTDVWIGAQLDTPPSPATIDSQSDSQTGGDYFPPSEGSSTESPAAQRQQQEQQQQQARPANLSLNISALPPALSFSAGMSPASLVSTSAPFTDATSLSLVGDPSDDYFRFAEASIASAANGDQASGAGIPFAPQLNGQPQQQQPQSATHPRINTSASMNQTPSAPLTAPSTTGTFPGSYRVPASQPTSPVRMMPSTQQLRQRSATTSIAGDNGAPQFSNGVSPNGVSAVPTHLSFTAIHGGSGTASPVVSTTPGGGDHAASQVAVALGDVSMEDASHATPSRPSHSRHPSANLLSNAPNPNVAQQMSSAVPTGNDIAERLTMERLTMLDTIVNQAQNAKEALLRGEGERIPEALGQISTQLEIASDLGMAPVPTPRETTPGSNGQTISPMNYSPTAQQQTMAAPNLAAAAPALASILPVPPQQQQQQQQQQQHQQHQQHQQQQQQQQQQQHQQQQTQPPQPLSVVTTPTVTSPVSMSATASTMMHPTPVSAPPLVHSHSFPNAHQLQSQVHQPVQNATVPTTPINGGTTNFAGAVGMHHPPAISSPLAAVPPSRGQSPTNGQWMPDNSAAVMAGMEQMVQAQAQAQAQAQAQAQAQAQAQAAHQIAQAAQAAQAQAVAQQQAAAAHAQAQAQAQAAAAAAAVVSQTQPQQSQGDGQKSRRSSVVEHRADGRPIARARSSSVVKPGHALSMSTSMPPSAWQSRQGSPVDDDDDDDDDGGDDDDTQPRRPKRRRSSAGPEMADVGNTSGVVISDDIRAQLDKIFNEFLNKVCSDLEMCDSKGEKIHQVLMPKKMQRLDESPDYRPFKFRIQAFTNAFHEELQSRGITEETMSIKKVKVYLWHQELISRFNADGKKAKSKGNHIWHVDAKKLPGGGWVFRPFKRRIIILPQPVAIINHRYEWEPKIWDPMAPSASIKPTFSSPPGSLPPWLRWEDGTKLAGVPDSLQPPVQVLARAEFIDGAGNPATLETQFVIQVAAMPGNPEPMPFTAAPVPGMHPATQWLPPGAEGSIDINAMHQNMMFGGQIPGHLYPPPGPNGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIN7</accession>
    <name>K1VIN7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIN7"/>
    <dbReference type="FunCoup" id="K1VIN7">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874890_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIN7"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="318" mass="34736" checksum="EDB96344AAB1CE78" modified="2012-11-28" version="1">MGSTEKGQAVIGRQQSPGMRAAKFIFHSGVAAYMISAYRALSVITERVVTEEVSSHTLRIGPELTAGWRRPPVPDHLGEGRNGEQLDVRPPSADSSFLMATATMILSAICDVFPDNWLTRASKRVLALGAMPIELTISAIYWPLILFAPSLIVPPADPLADVTKIDTGAELFFIPLWMDLGLHLVPAVALLLGEFASNTTPHFGETSRGKRHRCGVLRATRARRPVNQQLHDGCSQLTPDFFLLEKKYTPPTSTRGAFLTALGVATAYATWVERCAALNGKFPYPFLTVASFEDRCKIYVGAGVFALLVFWGLNALHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIR4</accession>
    <name>K1VIR4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIR4"/>
    <dbReference type="STRING" id="1220162.K1VIR4"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508257_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIR4"/>
    <dbReference type="OMA" id="PARIMLC"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="210"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="500" mass="54682" checksum="D8DE41414550BC81" modified="2012-11-28" version="1">MSNPFTSPPQRRPADLLISTSDNEVELPDFGSPLSSPRSQRSQNAPLLHSLSASPAPGQHPCEAGSSIRPRSPPPHLARLLNEPIDRPFSPSARLAENGGALAGDPAQEHTSLFPERHGPSARWYHGPLFQAGIKLAILFAVFSTLCILTFWFGMPKVEPEDRPALKLPRSFDDLKALNSLLHKYKTLYPARIMLCGVVAYLYVQAFTLPGSMYISMLLGAAFGIIPGLLLSCFCEATGSVLCYTLSAILAPPLLELPFYRTRLQTWRTKIMGDASKGQQASWDSVFTVLVILRILPLPPHWIANFVAPHLGINVAFFWLTAFIGMIPMSVIHVMIGSSLDQMTSADDFHLISVRNVLGLAAVIVAVLIPITLKRIFKKDFGDLADTPAGQQDVDHIDDIPAPQPIEFDEHGLPKGYQEVDGGVRVAGGPAEEEELLVDVPKAKYTPRGRPIDVLTNFDDEPPQGSFYELSMARPKPKRVFGGKANRSYGTLDAGPSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIU0</accession>
    <name>K1VIU0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000336">
        <property type="protein sequence ID" value="EKD00651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIU0"/>
    <dbReference type="STRING" id="1220162.K1VIU0"/>
    <dbReference type="eggNOG" id="ENOG502S5V9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287880_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIU0"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="928"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1069" mass="116464" checksum="7A5D0D335FCFF818" modified="2012-11-28" version="1">MYNNGRANTGVSPEQRQPDPHNRPPVHTPTSARSMAAAGMADYTNRLAPSYQAAPDPPGVGGGVWAPPGQGGFQQAPMFAPLGPPMGYDAEGMGRDARYGYPGGQPQGMNGYLPRLDMGYMNMGGVWDDNQTSPQRRDGERGPLSAVTDPGSRPPTSGANGVPPGYPGGVQVKEEPPTNGQPVVAQPQQPEDGENKPDHRKRKRNRTIRSCVPCHNHKRKCDRKRPCGRCTALGLTGSCVYEVDEARDPNDPDVIETDRLRRRIAELEQVVRELRQRHPPRTSAAQQAAQQAAQQQQQQQAQAQAQANDADKRRVLVDRYARFKSGEVAGGAVVPTAPSLHSMSELSPTASSASGRRDHYTEPYSAHALPGEELVSDPAGRKTWLGTPAGKPMFRRLREIVHGKKIDGTLPEDAAFTGWFASTRKTYPFTTIWSHDNFIDEIIGLLPSAEEAELLYESFITEIGCMFQAWHEGNLLADFRAFFALSAADKKTQPLSHLSLFIMICALGSMVRASSNEIMGEGNEGSPTSTSQRSDKGDLTSSRLQSELYLSAAYQALRLCSFQSSPTIATVQSQFLVCVYLLHSERAADSWGLTGSLVRQCIAMGLHVDPTHLDPKVSQKEAEIKRRIWWSVAGLDALLCVSFGRPTMINYYTCALPQDVTEESLSEETGSAVQAMIPPPSNALGPETTDETFHAALFQLTLPSVELLNRVFHVSPLVARNAFMGWFTPSTFEEPTVPPTVVGNSYEDAIRLGRDIFDWYDHLPEGIKFDPSKDLDQLQGRSGVRINQTLALCVKTFILVLILHRPYLRADPSAYPESSSLCARSAHIILQAYHAMARSKSTIAWSWWTMSYRAFHAGTVCAFLAIREPGTALAERCLADLRSAIAIFEDRTQNWNILHPVQSDLCTGLVRLEKLATAAAATSPGLGVVSQQGAHSSANGTGGAGNGLGTPQLQDQPIFPGLSLDPHSVPAFPSAMNAEDHERQHMGEGSTGSANSPPGLLRRESGPFLQPWALPEKQVNCPYGHTESLALPQIWASMFNIKMDEPGVNESMGPPQMQTQPSAVSAHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIV2</accession>
    <name>K1VIV2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_06592</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIV2"/>
    <dbReference type="STRING" id="1220162.K1VIV2"/>
    <dbReference type="eggNOG" id="ENOG502RDFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1876898_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIV2"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC99051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="114" mass="13151" checksum="7BAA068AE2133BE1" modified="2012-11-28" version="1">MSVATVNPYANHSQLTPLESEVLWEYAKLADKLKRIAALARETSEKPNSELLVDLRELERKMKLVLTLESRFEAEAEAAEEQDDQTVGQYHQSDASLQQRWDDQWQGDESTIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJC1</accession>
    <name>K1VJC1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein FRG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJC1"/>
    <dbReference type="STRING" id="1220162.K1VJC1"/>
    <dbReference type="eggNOG" id="KOG3962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062276_1_0_1"/>
    <dbReference type="InParanoid" id="K1VJC1"/>
    <dbReference type="OMA" id="NERFWIR"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32393" checksum="A5323CC41190CA53" modified="2012-11-28" version="1">MSGVGRLKFKGEKSKKKKRSHREKRDDGDELDALAREDPRGWMFPAKSDEVTGPTLVLLPTEPLSCLAWDPTRERVCAAPLDLPEAPEGFNELSPSEVLSFVEPSDVNHVWVVSRLAGSNGVSLRSATGGFLSALPSGKLDVSASRGPLESFITEVIPSDSAFPGFALKSEPSGKFLLADKPDKETVLAKKTEIRCDGDEPQGGIRVKCQREFVLKVRLQQLDGKDSSKRRLLEPDGPEEGSVEDELRRNSQYQAWGGGVHKVSDKDRRELKRAKKDGRVAEAMLDRRSKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJN2</accession>
    <name>K1VJN2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJN2"/>
    <dbReference type="HOGENOM" id="CLU_934426_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJN2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="279" mass="32193" checksum="49B4CFC17BF320B6" modified="2012-11-28" version="1">MSPLQGYRTPWNEYPDWLGRYDFAVKVSPYSGPGWTHVERVGNGPLSRVVRYQGPPVGGVLSRLWRAIRPGPVFFTSFLYDDGGEHEVPRAALTNGFRQLVGDWHDLRRLALSVYVAWDLAPFQGPEGQRVPSRAEVAELEMAFYEDLLDMSKRYAKIAARLHWEAEFWGQYLAHLSDCEDAGRLPPPFSRFPGQIKNSVSERFRYRLRMWRDGRTIDDYIFRAAQGLYEREDTPELTDLKESLRDLRFKILEAKGYPEGGAKLDLLDPGRYRPPPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK79</accession>
    <name>K1VK79_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK79"/>
    <dbReference type="HOGENOM" id="CLU_131111_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK79"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853859" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="175" mass="19649" checksum="F7828D940A53E59E" modified="2012-11-28" version="1">MSAASLAVVASLALFSTASAKQWIEAADSTPTWHSILLSEQYGVFRCLDNRDGRKSLGNPVQAWECNENNNQQWRWIDGLDREGNLPAEQRAKLLDAQREHPPFIYQLKDTELCLGYAIDSVDLSKPRMWPSGQIETAKDIQLGLWPCSQAPAFFYDRATNAMHLYGNPKLPQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKI1</accession>
    <name>K1VKI1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKI1"/>
    <dbReference type="HOGENOM" id="CLU_683678_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKI1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="491" mass="54471" checksum="6278C73A9B4483D6" modified="2012-11-28" version="1">MSFSSTSTTSTRLAPIPSVGDAELSRSSSLQPCISRASHGSRTSRTSTVVPGTPRKSLERLPSHVKCTYSPPSYDESNRQTFGTVDEYGNQWRCRLGVWYVVRQKGPRKSSTKPSDAPVVINGKEWRKRFGVCDYFPCIVKRTALQHVQRHDDPRSPTIILDRQAREDPRACITDPPPTSDPGEPRALLRSDVRSIRLSDGYVLAAHRTLTAVQEEGPPTPPPEPDCPPVVDRARPPAPVPANLRPHSDSQRGPPTRPAPQRTRSRSATLPSRHIEEMHELAGELDELPTYAECARDRPPPIGPPVHVVHLQAPHGVHVVNGVQVRSGRSQSLGAAVAGWAGPDRSPRDGWVRDSDGQWRQGRRRAVPVPASNPAHPSNYPLSPRSQARTQTSRSLPSRLGLEPRPHPPHSGQHTQNQSQREQGQRPGHGQILLRPRSRQNNEPAGNGKVWRKKLGVWYVARKEGFFVETVGPQGERWRRTLGVWHVVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKW2</accession>
    <name>K1VKW2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase SHPRH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VKW2">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKW2"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_1_1"/>
    <dbReference type="InParanoid" id="K1VKW2"/>
    <dbReference type="OMA" id="ISAMHIN"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="581"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1311"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1364"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="872"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1392"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1605" mass="180798" checksum="E7F3020E97787C71" modified="2012-11-28" version="1">MSVLPTTSSEAIYLQTSEYDLGQLTKAMKATKSGKRARAAPIPDEHMHLHTLHLQATLQPEPEIVEYPNGFRDNDSYPVWRDFRRSVHDSVEACVPLPFFPPTADLFHIDGHPLKKKKSAPVSCGNVFRPGNTTKPLVKIPDICTGSDARRQFFPSSYTWDHLNWIHAALAIDPDEPPTRRGTYKPNEKRVYFRTGVDVSWTPGDSGEEDDYAITLSIALDVYLDMDVILLPQPDISNDLLGLVLVSLLPADLGDQPHPSREGLGAARADALKAFYAALRPAPDLPYGFDARKLQPDSMTKPLLPFQKRSVARLLEREGSPMVTGNKAFTYPEGQWVKFDFGKFGEYAFHRLTSQLVRLKGDPKGKRRAHDSSWEDTLDHVFPLTKVRGTMLCEEMGLGKTVEAIALVLLHPHPLSLERPMIGAAGSANARKLPEINLEKKPEFGLTIQQWVDGQAKAFANSVAWSEEGQLNVAAVGTTLIVTPQSLLNQWVSEMKLHAPSLRVCVYPGWSDLIKQVEKRRTATLKERKRQAAKNLKRQRVKFRNESRRKYAKGAKGVKIERDSDDEEYIEMESEGEDEEEEEEEEFAPTPKSEDTESLLDVTQQAFLEYIRGFDVVITTYQTLSTDLNVADPAPRRSRRSTANYRLNERPRSPLVMVEWWRVIMDEVQLQSDSSTSAQMVSKIPRQCSLAMSGTPARSSISDLQGSLKFLHVPVASSVVWSRITQPSNKAAFEGLFKAISIRTTKAEVVGEFNLPNQTRYVVPIELSDIEMHYYLDVLERQRDRLGIADGPQRDQELDFSLYRNALRHLRQICTHIQVGGLEPTQRAGNRRGDRIQLGRQLMTMEQALKKMRDDLEENFTLTSRNLLRTQLDKAQLLVRDETDDLRNLKALAIYERVREGALKLLQEAKAELNKQTEGREDSVDDEGHMDESQAERAKRLLVQSARAAVRETMNILHLSWFLQGDVHHTNKEEELEVQAYQNAENIRREILARPLKAADRIVKAMSDAIADHGAVTSLGDLQTKDTRRKGGMLSGDLVAQTNSLLKILNDNAVLVYNWRNKVVELLETPIEANDEAVPGVGEGQDVENPDEEYYAEALKAQVDAYLTAYAAAIADRKEMLLEERTLLAVHDAHITKKRSTANSKDAQVIVDPDLPTDVQDLTVKLLLERNAFRERRTEEACERPLKALLIDLGNIVHAASRPEEAAIAKGIADMLRGYIKKQTEIVDKLNKELDMLRDTHNGRVKYFAALQEISDSVAVPRFRDVKKEIEFKDRQILDAETTLARWSVRRRYLGFLDAENQNVDDLKENCAICFGTSDDTHAVLLQCGHMFCVSCFTEYRKAPYIGRKCANCKTAIDDRGIQRVRIKAPEEGGSPKAEPEPETEAIEAEPSNDKRDEEREVERRAADLAKLNMLSVDRMRPVANIDMMGEFGSKPGVRHVVFSNWADSLRIVERALTVNHIRFVSLDSNTKKNDVVHQFQNDPNITVFLLHAERESAGLTLTAASVVHLLEPIMQHSFELQAIGRVDRLGQEKQTTVYCYATMDTVESRILSQGVRNGTSIYLNDKEEDEKVAAALPNVPHAAERGGDITLGETGTAELLRLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKW3</accession>
    <name>K1VKW3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKW3"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000249_0_2_1"/>
    <dbReference type="InParanoid" id="K1VKW3"/>
    <dbReference type="OMA" id="TKEPYMF"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2690" mass="294483" checksum="16E6680DFB65C2FD" modified="2012-11-28" version="1">MPLRRSSGQTFASPSSRTIRSLDIQHTDNLSLHDAGAAVASNSASASTSASPANTSYSSRQESLMSEQKVVSSIVSRLVNKLPCNSGIKLAMMELDDGVKTTVESLLQISRIRLSLVVHALASALETLSKVCNSATLSQLTPQYSNNLPLVDAPLDTIHSQLYVLHLLVRCLSESWRLNSSAATPTASDLPTCWPDPPPLDDHLARHLLGVLVIYMRMVSDDSAQLSGALSQIPRDGKSPSSASVASWAQEHPASTGYSLGPKFIQEHSYPSASASGSITALASEDARLIGPAASSIPMAIKELTKCTSRIVFFLSASNWPLVLSRIKARVAHLTTTLEENPELVELRLLEWANVDSSRLAQALQEISTPFLHVKRPAQTALASALRNAIWNWIDVYPAEYQSLIEGTRKLDGSPDVLFDVLSSMSDATASNKRVKVFYPLMAMLLVLSPESMKRIALGESSRGNSSIAKKASFMENLRRGLGQSKSFEACAVCYVDLVRAGVSLSPRLDSSGIRSMLPDLQSDLKNALFYSSLSTEINDQNVLVEGLVALYRYNPSQTASHIFPKLWNDSSDISKIIGVRACKAIVLEGQRLPWQQSANALRADVAASLRAILKSHVNSSLNGSSSRRPGRPSLEIPSTETDLIWETLDLIATDPAFAFESIGDGNDTLGQLLISISSLTAATNSMTIRSQASKTNLAILHSLTGGAKTDAAMTQLTATTAPAIWQILIDASRQLLIDFQIGDVNDMAMMAGAFRETIYAVLETVSVLPEIAKAPNARNAVLIAKVATITSLTGPDVEQTNLAAPALMALSKLMLIVRSAISNSQAQMDEITGHSQMLAELGSLPPATGRQQQQRAIRRIMKKHVRPSTLLSTVWLGLAARVKTLTAKIIAAESDEAADRGDFRRRGLANDIDGLTEEESKEWQNLIAFLCATSNVCFHDMSLPPNITEVVGKGVLPRVYDEATDAHSAVESFLRQCVDFLVSSSIHVRESIKDALGNELPLSLCRVLVVQMSKLLSHSAKSGSLNTADPYTTFTEQAIAVLRLWVDRVNPGENAGGVQVDMGELLFMIAQYTHRLGREDTYIRIKIKFCQLMEAVFSKPEFVVLGNASKLRNALLEWMCEWSIESFRDEFHSNAHDKLQRDLDLACLRALIPITDGLVIRQVGDDNEETQLVVKSRLFYRYYHMLVRVLERSNSLETESSQVAASVSNLSMRVGPGESYPALAILVLSNLLSANVDVGLKHCLSLGYHEDSSIRTAFMQLITNILQQGTRFGGLATKGGTSAPKAYFDALTAPNLALAMAICESCPPGEVDEISMMLFRVFESKGTLLSLMKVLIEREVAQTNHESELFRANSITTRLLTIFAKTYGYNYVRATLQPLIHSLSEKPAECSFELDPSKAGADDIERNAEHLRLMCQALLDIIYQSTPRVPILFRALCHHIWEVVEERFPDSRHSAVGSFVFLRFFCPAIVAPEGIDLDVNPDTRDTRRALLLITKVIQNLANNVLFGNKEAHMKVLNQFLSENIRQVTKFLSDVAVRPRSWEVAHATKTFQEESERSLDADGDNLIIQRFVFKHISRLESSLDNLPPSFRSRQSTSTRSIRLDLDGKSMLQSLRRLMQETGPPTDMSNLSSSTRSQVYDDFMRHNAGRSTESVNTAFYEGPASQNGRRIFYFVVARVALVDYDLLAYHVFSLLDKVTDFFDLVIDLTDFSPTTEMPIAWLRRSLQMCPPGILPLVHTLALYNPNSYARKRLRRMIADLSTVGTTIGKSVVAASSPAELAEFIPFTSLALPDHTMALAYEADHVFTNLLCLSDHEMQVPVVVKLGDDCLQVASWRKQDLTASLKAYIIDVINLKDVDDIVAGTGVSSDQLIVKHSQNQSVTFISRKRNEMAQIIRTARGRLRDTPSEDRALRPSDVPGTLLNVAFLNMSSSDEVLRMGAYNLVNELCSFFKYDLSSQISKVNSGLLIPTNSLSYVYKLSKQLATSAPNLTLEFLKEWTIGFAKADTPQKTACLHYVGPWLNNLELFAKPTRDDGVESVKQVAEIVRSLISLTVAEKRRLHLTLQEHVWSVIGSSHEALVDLVVTELLHSAVNAGPGSEKAETVADILVSLNCTAVKGKVVARLRKTIAQTYLRPTASLTDSASWNEICTLARINLALAFNPSNAIDTQLFLPELFHTITLIVGIGPVFMRQTVHGLVVNILQSLASISSSDMDSASLLHLLQRLQQPEMIAAFGLSQSAGSLELSGLPQWDQNGVSHLDSLEMIVKFLGDVLSAGAISTDCANAWRARWMGLVAATCFQHNPATQPQAFTALGYLASDEVDDDLVYQVLVALSTTLTHFQETDTVLIVSMLRCLARVIPGLVPESRYAPTMFWLAVAVLQLAYIPLFAPALELLLTTVRHMNAIGSFQNGLFDNLLAARKAVGDSARKLDQICGINFDTDPCFSLVAIMYKGVRHPNTRRLTIATLTEFLRLSTATRTDLNSEDSPLIGAQSVAFFTSLLPISSANPSDLKGLFTAAGVDVAEEELRDLSTLSVFDLLAIPDNSTALLLVTLIVTILGQASTDTEKLVLYRLLAEASIEMPEVVAMAYDSLIPRMTAVLTTTASTSILSAVTLIFERAMADSTYSFGAQANGDRKYGGSSLGSNVSGAREQVLEDLGMKGLSDMSFQGVKIDRLGSMAKWVASLIESLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL21</accession>
    <name>K1VL21_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vesicle-mediated transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL21"/>
    <dbReference type="FunCoup" id="K1VL21">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VL21"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_4_2_1"/>
    <dbReference type="InParanoid" id="K1VL21"/>
    <dbReference type="OMA" id="HIRAKSM"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="253" mass="26676" checksum="7CDBBF485100A1D3" modified="2012-11-28" version="1">MFNQNAYGQPSQGYGQAEPLAFYQGSSSQQQGWGQGSMASGSNYGGNMGSMGNMGSMGNMSSGRVGGMMQGEGKWWHAFGTGGLEGEPSLMEELGINPSHIVQKSLTVLNPIAKVDTNVMDDADLAGPLVFCFAFAFVLLLFSYIYGVGALGTIAIYTLLNLMSENGIDAYHTASVLGYCLLPMVLGGLGVGIGVAQSIGYALSVISVLWCTYSASSIFVAVLQMSHQRLLVAYPIGLFYGCFALLSIFQVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL50</accession>
    <name>K1VL50_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL50"/>
    <dbReference type="HOGENOM" id="CLU_319151_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL50"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="911" mass="100438" checksum="CA31CC096CD98F4B" modified="2012-11-28" version="1">MNWSRPGVPATAVTPKLPWSFISSRLLHNWSLDRPDIPDDLIVWLKGLQPCSQASSCPDLEGYFLELLSESALTLWNVIDQYHRDGTPGPPCRACPTNVSGAAVQICHNTPPDAAVCRLRPNSERPWLFDIMPPPSADAVEWVKNRLQEVHVHQLMEASWSRLSDPTADGALVGKRSSIKRKAKQVKRFFCDLPRIDLVGATASPAQAPAVALPKTREISVYFRNDPKVSQDGHRFLLSTAPSPLPNPATASMPKDSPKDHVFLEKRVLLELLKCEWSLNEEGKLPPPTEWVSYLDRGATDSTTGGPPLTPAVGVMVCEPNFGDLHASALLGAYKSCKVRFSLAFKVGSNRNGTPGALRPPAYEFDFGRIKGLTVLFLACLVIGNDAAIDKLLGMRVSGGVIIQDLIEQDAQRLLGATARHHVGLLLNAAALPTTKWPLSDLSYRLSLWFRVWLGRPTFSGYLRARPLHLEGLIKEMFNLWQPSGSVQPAAPPASVFASCAEGKTAAIIELTTLGVYYGSAVGTAALLAGKRIAKAAADCRRIDRRLKVGDEWVQNAVSVVTSVLRSSVNLKFEETEKWLLTSLSKEIVTGSEEEIRSLYNALHTVRLNLRSVIEYYGDEMDGLRLQKAFQQAFCGVLDQGVVSMDPEKVRDFFNFNFNDDDVSSLRDSKNFGRFNVELASKIYTDLASLETLSSTCKGSRMSAVIGSISQTLSELKSLIPVAQPHFALGKEKKSTWQALLPLGVVLISYCIWLWQPSPQLSPIRPLWPAARSENRVNGDEESLCTEGAGWMRADFRVDGLRLNRGDSVHIVDCPTPDRYMIKIQRTWKVSVSRRTEISGSLSLFLAILSACPRAMAPKPIRRNASTESVWRQSGQMSVGSPGLTFPRAHLAHNFVPDEYARLIETCVGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL87</accession>
    <name>K1VL87_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL87"/>
    <dbReference type="HOGENOM" id="CLU_1005396_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL87"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853884" evidence="1">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="277" mass="31500" checksum="7BE6795C79E2D4ED" modified="2012-11-28" version="1">MKLVFLLLFAFLVVTAPLGVLAAPLDNDLAISTLLPSTSYEKNGGARFAAQHKLKHPSRRSRHSKPIATATTHVDIESELDRLGLSHLDLQNWITNDDPQAVERQYAKLRALSPASSYRAKAHALACLVSMSDHPPRSLVWEYEWSIFYGTYLDVSTHDERTRELVEYYYDRVRRVRMHSSIRERAAAVARLVSLTANPTPDLIAQLEGEVPRDFAAYVCSAREWMHRAAEVIANWFEPIRRAFNPIVTAWNTISPYFNIAKRHSDALGAYFASYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLE4</accession>
    <name>K1VLE4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD05005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLE4"/>
    <dbReference type="HOGENOM" id="CLU_716086_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLE4"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43034" checksum="DB806D70C350D803" modified="2012-11-28" version="1">MDHNPLQRVVSVPSQCQEPPSTAALGNFDPLAVGADEPFTMCPSCGIHLDTVKTSHSPVIIRITNAVTARLQLDSHSRSSTSIPLFFSSDTVKGRLEIEVKHEVKIKAMKLVVSVSSLIVGMASPAYRLVQAQCHLHIPEDDRLISLNRQDVPLYTAGTDSANVTVATYSTPRVDSGFSSTCHLNVLPETMAPGLYVLFAEGREAPGSDEDPEGWTIFFGAMMREWPGYRLWLHLPSPLCYPRDLPVRLQVRISPVTWQTATISIHLEQQLIVCGPPYRSPHTNVISLAELVGEREVRREQRWLDFELRLAAAKPSFANSDVRLEYRIVVRMLAEAHSPSEILSVPIVLVTDPARLHPQVQILMRHDLGHLPPKHERSEPPRYSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLH0</accession>
    <name>K1VLH0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tricarboxylate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLH0"/>
    <dbReference type="FunCoup" id="K1VLH0">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLH0"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052717_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLH0"/>
    <dbReference type="OMA" id="VEMTKHK"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="203"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="299" mass="32206" checksum="A1884534857E1694" modified="2012-11-28" version="1">MAPAEKGFSWSNIAVGATMNLFEVTTLGQPLEVLKTQMAANRSQSMAQAFRTVWSRGGFFGFYQGLIPWAWIEGSTKGAVLMFTSSEIEKVSIRDLGVSPAAAGMLGGIGGGIAQAYATMGFCTCMKTVEITRHKQVEAGGKPESTFKVFADIYKREGIKGINKGVNAVAVRQATNWGSRFGFARLGETMIRKAKGISDDKKLGAMDKIFSATIGGALSTWNQPIEVVRVEMQSAIKDPNRTGKKTIANTLKYIYETNGIKGLYRGVTPRIGLGIWQSVCMISFGDAVKAYIASGGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLZ6</accession>
    <name>K1VLZ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoprotein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLZ6"/>
    <dbReference type="FunCoup" id="K1VLZ6">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLZ6"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444949_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLZ6"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="614" mass="66613" checksum="2CB2434975E43BF2" modified="2012-11-28" version="1">MTTSAERSARPERSSAGRQLPNPVAELSDHFLFTTLTPKEACQGPYAHPTTGRTIELYTLDDILVYTPFKNDYGPLNLAYTYDACVALYEKMKENKRRPVCLYTGPTAETKTNLTLMAALYCHIDPWEAFQTIAHIEVIPFRDAGNGPNEFALSIQASQNKLLMLREFDAQDYRNGDLNVLGPFVAFASPMDPVWIARNTPEGEKAPEYTSGQKRMLVGAFEKVLNKFEDEEVGVVIRLNDELYNKERFLERGFKHGLGRTGVLIGAYLIYKYNFTASEVIGYMRVVRPGMVAAVDAMRRPAESLPTPPQEYEDVSLPEEQVEESRPRRPLTPARMVQSGGTTKQGDAVGQPRKGPQGKNTTIELTVVADEPSSCSSRAGKDRTDASARGVKRGSTRAPVASTGSQSVRGETPNGDLTAQPVLARSPSNASCSSSNSEIDQRSPKRRPGDSPLSKSGLSSPPPSRDSTPFGDEDNSTFPIAEHDEPQTPPQQMKKLATQPLTPPSPSLSKDNGRTIPRRGALPFGKEEKASATSSVSGSTASASENSAFSDSSDPAEPKPPAPVAISPRAKVSSRRSNPTPRSWTTLSRLGGAVSSMVTPVANSTDSETTRTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM27</accession>
    <name>K1VM27_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM27"/>
    <dbReference type="STRING" id="1220162.K1VM27"/>
    <dbReference type="HOGENOM" id="CLU_2656214_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM27"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="76" mass="8300" checksum="73C3E7E2867D0033" modified="2012-11-28" version="1">MDLSQARAASLALDFDVDAEDEEAAAERTLASATSGLTQTRYEPAYSDGPSGVRSERSPQGVNHLTEEDEELWDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM59</accession>
    <name>K1VM59_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM59"/>
    <dbReference type="STRING" id="1220162.K1VM59"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314275_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM59"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="479"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="758"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="947" mass="103087" checksum="B9599F8ABF018DDB" modified="2012-11-28" version="1">MPASPKAATMSRQQAPPRSYSLATGIAAKLSQPINSSLPDLPRIMSSGIDTNLLTPVSSAHSSSTTPAFGPFSESEASFYTSASSVESSCESSDGLASPWPRRLSGPGGKIAGPAPSVLPVVVRPDSLTSSTDEEMPTRSAWTTAPVRRHSSKRYGWSKQPTEAYPLPVSPNANASRYSVASCPTPNSHPSGPSIRVCESSRGAPRLSFVRDGMESPPQKTLEFGAKMTNSPTSKESPSSGEPSPTGARKRRLNALRGLVANLDFAQPWSIVDQPHHDETGKYFWACPGDPPPQLELSLGTKFDGKFEVDEPTPTSPDLGSPVESDTDSQSWGHSKSKSFSRSLISVVHDDDDDNRERSISPPFPMVDRPASTTPRAAPKKLGPLTSASSTHLLPPKTSALARSTSRLRKSASARQVREPPQPPRQRQESFHVRHTGYTKSTRPVMPRVETGRTWREALNDSDIYQNIVSQEDGEKEVKRQEVMFEFCETEHAFVRSCRDVLRLFAHPLKTPDGVWMSGIPTHACELFDLLEKLTDTHDELARALQGLPRTNGTVQVGQFVTAMRPWIEKLSCHEPYIASFHPVSQFLDEETRNEMSNYGEFLRMQTRNPAMGAMGLTSMLLKPIQRLTKYPLMLYRLLDATPVGHPDHAAVSELIEATETVLSHLETCKAREDEFQQLVSIQQRCDGLPLDFRLATRGRRLLGHAQVVRAYAKDAVVHPGAHFTRSHTLKNIRSSLQSALGAASTTDLAAYAGFTSSDASEVKERPSRRSTRDSTTTTSSATSATSSTQSLASSLPRRPPVSRGASLISSDGTPPPSKSPSIRKARRDDVYTMLIFNDVILIAQPMADRGNLFRTKKSDLARLRLVPVAEGGLGSVDDMKMLVGNGTAEQFALTVRGHHGPVNTTTYALVPPTSSLSRRTQRSAAIGSDGIATVDDLVETIGSMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMF3</accession>
    <name>K1VMF3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMF3"/>
    <dbReference type="STRING" id="1220162.K1VMF3"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="InParanoid" id="K1VMF3"/>
    <dbReference type="OMA" id="HELQAPM"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="135"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="576" mass="63617" checksum="6E234BF95F49DA67" modified="2012-11-28" version="1">MSRHNSLERTKSQTSSYHDPEFVPEVHLSPITSRASRRDTEAIGEGNEGLSDADTRSTRVAPEMGEKEYIEVTWDGPGDRCNPLNMKAWRKWLELANARLMVAILSFSCLCITCCSSMAAQTYPGMSKAYHISELVCVLSISCFVMGLGTGPCECQSLSVLLPAQQPLLVLDGGEEDYTRPRPIPLLTAVLLGPVSEFVGRAPVLHYGLLIFFLFNFPVAFSTTPSVHFIFRYLTGFAGSGFLSVSGGLVTDVFENAAVATPMTIWSISPFMGPILGPLIAGFINYNQPDWRWTYYVVIMWAFVCLVGLFICVPETFAPKLLERKAKRMRKETGQNYRAPMELKQETFVMALKRSIKTPFILLATQPMVLLLDLWSALLLGILYLSFGGIPYIFRHQYGFNMQECGLAFLGIGVGQLISGATQPYFNRYYARVASRSPDGKAPPETRLYMGEFGAVLAPIGLLLLGLTCFKSVHWMVPIVLSMFFGTGLVYAYNATFTYLVDAYRPAAASALASNSFMRSSFAAGFPLFGNQMYDRLGPVGATCLLAGLLFCCTPFPFVFKRIGARIRARSEFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN96</accession>
    <name>K1VN96_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03478</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN96"/>
    <dbReference type="FunCoup" id="K1VN96">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN96"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_0_1"/>
    <dbReference type="InParanoid" id="K1VN96"/>
    <dbReference type="OMA" id="ISWGIVH"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="534"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="836" mass="91957" checksum="21647BC64F4F4DB5" modified="2012-11-28" version="1">MGNIKQSVKNKLYDWTGYDPNAPQSVTVGDYLRDHKTDIREAIKNYILSLFPFLQWMPRYNLQWLYGDLIAGITVGMVLVPQSLSYAKLANLPPEYGLYSSFIGVLTYALFATAKDVSIGPVAVMSLETGRIINHVQHAHPDKWTNPQIAVCLAFICGFIVLAIGLFRIGWIIEFIPQPAVSGFMTGSALSIAAGQVPALLGTSKLFDTKAATYEVIINTLKHLPDCTLDAAFGVTSLALLYFIKWGLTYLQKRYPRYSRWAFFAQALRHAFVIIIFTIISWRINYPNIKAGKKSRIALVGHVPSGLQHVGSPYITTDLIAAMGSHLPVATIILLLEHISIAKSFGRLNGYKINPNQELIAIGVNNTVGSVFSAYPSTGSFSRSALKSKSGVRTPAAGIPTGVVVIIALYAVAPAFYWIPNATLSALIIHAVADLVASPKQSLGFWRVSPLEYIIFVGAVVWSVFYTIESGIYWSLVCSVVLLLFRIARPKGHFLGRVRIAPENNKGETRDVYVPLCRNGVTNDDVTVEQPPAGIVIYRFEESFLYPNASYINDKLVGYVKEHTRRGKDYRTIKMGDRPWNDPGPKKGQEDPSLDDSHKPLCRAVILDFQAVANIDTTGVQNLIDARKEVEKWADRSVEFHFCGILSPWIRRALIAGGFGTGAHKKGVALEVAPIVRPYGVGGDADPEHTERPHLSPRPDLESGHFDSGVEAGPSSTPTSASGSSSVFSDSDIKHAYSASDADATPRDSHDKQGSITLLDRATPFFHFDLADALNTIAVEDLHDNKEKGTKIVHAIEGEEIVREHQVLEDETPKDPHTITQVAPVDPMPEHQTRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNQ6</accession>
    <name>K1VNQ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNQ6"/>
    <dbReference type="FunCoup" id="K1VNQ6">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNQ6"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="K1VNQ6"/>
    <dbReference type="OMA" id="WILCASM"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="89"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="614" mass="65739" checksum="00480D7E8EE96BF7" modified="2012-11-28" version="1">MARPETTRTNGNGAGRPASVANSFSTNAPSTNGANTPTERTRLLASAGPNGVTVEREDTISYATHVPEVPTQKAHYNLVGLSQYNFWVLCCSMWSCSFLASFDGTIVATLLGPISSSFNASDLGSWLGTSYLLSVCCFTPIYGRLCDIIGRQSSMLIALSFFTLGNVLCAVAPTMELLIAARMVAGIGGGGLTSVGSTIMSDLVPITHRGIFQGWGNIFFALGSGLGAPIGGMISDKVGWRWAFYFQIPLLIMAGALIWFKVRYNSEFKPSGNILKRIDFLGSGLLAASIGSALLAISMRTSISPPESRITNGLFVISAISFVLFIYVELKVANEPILPVELLTQRTPIAVAVNNFTISVLSFGTMYSVPLFFQAVRLMTATEAGQHMVPNSVLGSVGSLFTGYIVRKTGRYWWLTAFCGFWAVVSALLLSTWDLNTSDFLLWTSFCPMAFAMGSVTTLTIVGLIADIGREHVAVATSLSYMFRTIGQVLGVALSGALTQAVLKRELHKRITGPGSEELILRIRQSSEEIRKLSPKLQLAATTSYGKALHAVFVCSVVLAVIGVLSGMGMREVDMNKKPAPLTTEPESIEEGGQRSYAAVANTPRDARNGSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNR0</accession>
    <name>K1VNR0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNR0"/>
    <dbReference type="FunCoup" id="K1VNR0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNR0"/>
    <dbReference type="eggNOG" id="ENOG502QPV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026648_1_0_1"/>
    <dbReference type="InParanoid" id="K1VNR0"/>
    <dbReference type="OMA" id="KQDRTTY"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="592" mass="66787" checksum="F321F614357EDD0D" modified="2012-11-28" version="1">MPRPTTTHHNSPRHFYIILQQPSTRPFDPHPPSALDSNPDSADCIPAPRHSSSVLSVHSSVICHPKHYLHPRQSKTAFATVQASKPSPSVRAAGGPYLNPLLLISTFCHSSERAPHVVQHGSPGMSYTLAHCKTDGHRGLTTLQEELPILEAFINIRNRLTALKKDSTRFIRAQDVMSIYNQIIKQLTKLNAIREEASESALQSNPSNPPKSTYEPNRVDTIIADVFSLISLMFLTVGKSRESPAVYCQIASMRQILSHMDESGVYTEAYLQGFRDRLEELKTIIKNDREEGRHPEPVLKYMQKKLEGTEAILNELMESLSVLSIELVPIHNRLVAIRKQLTALATEPKVNKAELKAILEELRKIDSKRVDGKFLGPGGSSVPEGQALLSGLIDSCFDIVQDIKAREHEENVSLPLKPIWERLTTMKQQLEQLTLTHRWTLRETDLYNYLLSLREIDSMRVDGKFVDADGNKAEGQYLLLYLLRRCYGLIYRLMSESEPISEELMPIANKLSTIKKCLNEVHKYGGPYSPRDLYPYHLALHQIDSIRKDGKFHADDGSVPEGQAILNAQLSEAHELLEMLKESMSEDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNY1</accession>
    <name>K1VNY1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain fatty acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNY1"/>
    <dbReference type="FunCoup" id="K1VNY1">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNY1"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118853_1_0_1"/>
    <dbReference type="InParanoid" id="K1VNY1"/>
    <dbReference type="OMA" id="YFYKYYK"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="117" mass="12769" checksum="2E0D72071AC3B95D" modified="2012-11-28" version="1">MSAQFDKAVSIVRSLPPDGSVKPTQDQQLEFYGLFKQATEGDVKGDRPGAFNFAGKYKWDAWKKLEGMSQDEAKAKYVALLKGMLEASNDEVAKKSLAELEGEFGIGHRELTSPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPX1</accession>
    <name>K1VPX1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPX1"/>
    <dbReference type="FunCoup" id="K1VPX1">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPX1"/>
    <dbReference type="eggNOG" id="KOG2328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010510_0_1_1"/>
    <dbReference type="InParanoid" id="K1VPX1"/>
    <dbReference type="OMA" id="DFMPSRH"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="658" mass="72754" checksum="4F76FAEA8A4C5949" modified="2012-11-28" version="1">MSRRSSLALPLNMQVNDDAAERAARRRSAHFAPMLPDKETGQGAPHKSALSVQKRAKRLSAVAPSNPPVSMEVMNTNFEEWMKLATDNIWTSRVDSVATETGKLLSGLAGAPEEADEDEEGDGAEPRDRERRRAQRSEATLAKSFAALQVKKVGIDGTGRVVFDSGDALVEEDSDDEDEEEQHATVDIAKLRDFLPPQAEVEGLNISDTLNGFYFAADPKDTPDLMALLALDDQEEEEEEPFEPGPQGEAVDFFGDDDYDAPAFDGGFEEGDVSMGDDPFTAPPTAAGPFGTSTLVTLGGAPDTNMFEYFDSGFGKAWAGAEHWKLKRVTRRVVDPEVAREKRAAKVPFKISFEPEAKLSSRELFATSSASTLLPKRRTGKKATSASRRRDEYLLPDDMHFSSRQLLRLFLKPKFALRTRRVASNNAAGEIDETFWAQAAQDRESGADDFAAEADMPFESQFFHDDDDFVDAALDDAEDADDLRLETQGQELKRARPENVHYAKKAKRVDVKRLKDDIWSDLRAGLKIEAPEFEDERRESIHPPSEPTDEGEPATFDRVITSLRASYPRDKMSEISTSFCFICLLHLANEEGLKIETARTDGGAGDTGMKGYTDQEGVWDIEGVRPPRKMVTGNEVDRIVGELQALKVFRDPTAGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ39</accession>
    <name>K1VQ39_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ39"/>
    <dbReference type="HOGENOM" id="CLU_1246130_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ39"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22344" checksum="14118C3B91F157D7" modified="2012-11-28" version="1">MPTSSLVNPDTVAAPNPTSTLSRGPRPGPGEYALPIPEQIRALLQSRLAVTLTDGRELRGTLTSVDSTSVLMSNVEELREVTSENVRRYWPWSKDGINAGYDGDVEGRGAGASAAGVGRESDLQEGEEVGQGGEEGAEGGAEEEKKIGGGGPGATIRRRELQSILVQFAHCKSIELDEENHAAWRRYCEMPEEMRPNAPSQPYLGQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRN3</accession>
    <name>K1VRN3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRN3"/>
    <dbReference type="STRING" id="1220162.K1VRN3"/>
    <dbReference type="eggNOG" id="ENOG502S1CS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1289761_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRN3"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7137" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="214" mass="23290" checksum="E54ABF97A2F3F505" modified="2012-11-28" version="1">MIQPASSASQSYYKIASGEDITFKWNFTNVLATPESITVVAYCADNNVEYKVGPTDGSSNTLPGKATQVVWNPYEWQLQPGQTPFQQATYTLKIFDERGTGVALKAGYLTPYTGTKFGMYKPQAYTPFADFIVTGGGASTPREERRRDRLALRRGPRIDEAEDAYIDHNSEAMLCSVFGRGLSAIGTLGSAFLRALGGELHALPTANDNLGILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSL0</accession>
    <name>K1VSL0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyrate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSL0"/>
    <dbReference type="STRING" id="1220162.K1VSL0"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535493_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSL0"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="201"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="366"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="51245" checksum="588071B759D80F36" modified="2012-11-28" version="1">MTHTQSPKDVLELRAKYAVVVGMPTVERVQHIHAVNPQTHVGVIVLLPSSGLRVVASGIFARPLPKSIFLGEDQTLAPAYAVVEGALAALNTSVAREAYTLAVEGGLDMRTLSEALGSGAGGSAAFNALWGPLLSGESAETQLRNAAEALSSALALAGEIRFYAPLMALARQSLGPVTPNPTVKRKEGKAAKHPESQEPSKVAFIGLGSMGLPMAKRLHALPEVVGYDVSPGGREAFKESGGRVADSAAECASEAEVLVLMVVNVAQAEDVLLASGALTALAPGACVLFMATGAPGDVLRMQERLTAVRTDVTLLDVPVSGGTPRAASGELTLFCGGLDSAPPETAAKARAVLHRLGSIVSLGAVGAGSAAKLSNQHLAGCGISSVAETLAFATALGLPGRLTRELLLQGPARSWMLGHRGGNMLAGLRQPPTSAITIFVKDMGIVVGEATRRNVPVSLAAMVQQQFVFCASLGWDRDDDSGLVRIWELAGIDVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTU2</accession>
    <name>K1VTU2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02699</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD02982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTU2"/>
    <dbReference type="FunCoup" id="K1VTU2">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTU2"/>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="InParanoid" id="K1VTU2"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="288"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="769" mass="85333" checksum="ECE3EB92AAFF7C06" modified="2012-11-28" version="1">MLSRPFAAFIKAARTPTLQAPTASLLARRTYSTPKKLRVPYPAMAAVSDQEIISRLGKLNIAAPEVHKHAAVQGGAEWRAELDKIGQKGVQLTKTLLFKPKTAKSAEPTPVLVVAKDDTETSSGPLGALLKLKDLRLAAADLIKQVIPSAESKDDVSALPLPSPVPSTLFIVLDKAVASSSDLFALHLTTSASTVFLKGTDVKAYLESIAPSPEAVRVVDFAELKANAPAPQAKAAPKAAAKEQPKKAAKDDDLYEMAIQHKKEEDFPGWYTDVVVKGQLIDYYDISGCYILRPASYTIWQTIQEFFDGRIKKLGVQDCYFPMFVSQARLEREKDHIEGFAPEVAWVTKAGKSDLEEHIAIRPTSETVMYPYYAKWIKSHRDLPLKLNQWNSVVRWEFKNPQPFLRTREFLWQEGHTAFLTKAEADKEVTDILDLYRQVYEDYLAVPVIPGVKSENEKFAGADYTTTVEGFIPTTGRGIQGGTSHHLGQNFSKMFEINVEDPKATQADREAGKDTKVNVYQNSWGLSTRTIGVMVMTHGDDQGLVFPPKVALTQVVVVPVGLSKGEGKNQPIYDACQKLADELSAAGIRATADLREGYTPGWKFNDWEMRGVPLRLELGPRDIAAGTTLAVRRYDNFKESYPLEGIAKTVEGKLEDIQKALFDRALDKFNASVRPVTQWKDIVPTLDAKCAVVIPWCEDPQCEDDIKERSKQEAMKGQDEDSKAPSAGAKSLCIPFDQDRFGKFPEGENQKCVQCDKKAKRWALFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU40</accession>
    <name>K1VU40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU40"/>
    <dbReference type="FunCoup" id="K1VU40">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU40"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="InParanoid" id="K1VU40"/>
    <dbReference type="OMA" id="AYRNNEH"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="57154" checksum="962FCEC6BCD4FDB4" modified="2012-11-28" version="1">MSILSRMAPRVSMTGRQSSTARLSAVKRHLSTSPVAMADGKTSPTDSVLYEADGAARIYKLNRPKALNALDMDMVQSLAKEVNTWRNSDQCKLVIGRGDERAFCAGGDVKSLVEGRPTQGAAPALKFFQEEFEMNWEMGRLGKPYVAIIDGFTMGGGAGISLPANIRIATKKTVFAMPETKIGYSPDVGGNYYIAQLDGQIGAWLAITGQETWGRACYELGIATHYVAPEVLPDIVRQLGALEDPTAEQVSALVASYHVPEEAGLEPSSKASREGPSPVRGAIRKFLDEAFGKNSIQEIYAAVKKGESDSSLPKEVQEWAAVQRKHMDERSPTGMAVALENFRLTQKAKRLNTTLENDIRMATGFAGTDRPTEDFSIGVTHLLVDKAKGRANWNPSSLEDKFCEPASIKANFFDPKAKHLQETPKLTFRPEPETQEGHDHTWGQFRRYGLPSESAVREWVQGENPQAGAFKVNEEELIQRMLESTGDAAGPRAKEFAARIKQVVAEHCKTDKDGYLDWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUD1</accession>
    <name>K1VUD1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_05337</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUD1"/>
    <dbReference type="FunCoup" id="K1VUD1">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUD1"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008640_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUD1"/>
    <dbReference type="OMA" id="PLKMGYV"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="19">
        <location>
            <begin position="238"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="18">
        <location>
            <begin position="835"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKD00368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="943" mass="103866" checksum="65EBD871F0B00147" modified="2012-11-28" version="1">MAASPRPILLRHHQPALGLGRVTTPSRALHVRAISFGTIPRMVARAFRVPLYGAAIGAGGVGYANYKFEGVRTATMDTLGKIQDTLSGAYSSTAEKLGSAYDTTSSTLSELSNNISGGINEATAQAQTQADAFRTGAKDWWEAFTSQFVKPQETKSENSSKEESHTFKTQPEEPEPEGPSGGGEAAVAAAATAAAYAASDDDEDKQESSSESPAALVQLTKKLIEIRNVLLSVDQSDALKLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGDNMVTRRPIELTLIHTPRKPGASEPVEYGEFPDIPHLGKVSNFATIQKTLTDLNLSVPAEECVSDKPIHLNIHSPNVPDLTLIDLPGYVQISSLDQPENLKESISALCDKYIREPNIILAVCAADVDLANSPALRASRRVDPLGTRTIGVVTKMDLVPPQQGASIIGGNKYPLNLGYVGVVCKAPPVKSGGVFSSMRGDSGTITRAVLKRESEFFGGENAGFFKGYSRTGKPLMVGTDTLRRRLMDVLETSMASSLHGITNAVQLELEEANYQFKVQYNDRRITSESYVAETVDALKARFKEYTSQFKKPAVRAKLTDMLEDKVMDILEQLYWNDEVRAQELSRLGEDKKLASSEDIDPYWRYKLETASSLLTKSGIGRDSTSRVADGLRGLIDSIAAGEPFTFHPGASDRIVDFSHAILRERMGVTADQVENCIKPYKYEVEIEPREWEQGRERADHKFAEEIVLCDAKLAEIKQRVGGGRRLNGLVKHVSDLEKWQEEKKARAALGDEPPEGEDAGAEPQLDAYKYSPAQIIDGRHALLLQNRLALLKARQHAIRSKRCKAGPEQAAFCPEIFLTVVAEKLAYTSTMFINIELLEQFFYQIDSRILYDLDRDEIKKFALENPKIRKHLELQERRDKLEQVLRSLQSLVNLHSEQDTHSRGKKDSGLFSKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUT6</accession>
    <name>K1VUT6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUT6"/>
    <dbReference type="STRING" id="1220162.K1VUT6"/>
    <dbReference type="eggNOG" id="ENOG502QS1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_3_1_1"/>
    <dbReference type="InParanoid" id="K1VUT6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24448" checksum="9B4BC9C68907DEF1" modified="2012-11-28" version="1">MPEHVRVAQTDDEVWMVFMNSEPNNQLTAEFIGQLNGALDNVEQQWKDAGSKGGALVITSQIPKSFSAGIAEADSKDTKFINEVFEPLKTRLLTYPLVTIAAINGDALGAGFLLALLCDHRTIHSSKGTYSLQDAVLGHSIPDILKVMMKDAKAAEDTAGGKVWSTDDLYDAGLVEEVIDNGGMNLGMLGERSGEIAAEKGEASADGKHGKSKLQKFKDVLSKVKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUY1</accession>
    <name>K1VUY1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000339">
        <property type="protein sequence ID" value="EKD00573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUY1"/>
    <dbReference type="HOGENOM" id="CLU_577706_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUY1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="473" mass="50593" checksum="4F6289E8B1BBEB53" modified="2012-11-28" version="1">MNALAAGPAARPRPKVKYPDAYPHWHYPADFVLKPSPFVDSAVESAHVVRRHHHSLSLSLHSHSRSNSTTAPTSAASTSSPSPSSCHSRSASTSTTPARASGSRADPVSGVTDPAAAPSTSALRTASDPDTVAYYLSAPSSSSQGAARRLLDAFRPRAPVYLTSFVYEDAGYIESPAAPSTSTSAPSTSASTPVAAPPPALSTPDASVLAPVASATSTPTTTSPRASPMRAIRQQRCTRSELTAAFGRLVQDWHRFWAFGMDVLYHVPTSPPAGREAEFEERFGDSISRLRAVWQSTQYRLFWGTYLFGDYLEALSEMEDAGRLPSRWPRTGLDTSSRAVRFPGCSLTHRAPGGKIDDYAFRAAKVINAKQGERIPEVEDAYTDIESLMWDMLEFKGLDPELSLEALPKMRGAAYSTPGRFEPPPPPYAPPSYEDACASCSGCSSAESSSRASSRASSGWGSPRSSYDSASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVX8</accession>
    <name>K1VVX8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00946</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVX8"/>
    <dbReference type="FunCoup" id="K1VVX8">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVX8"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444815_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVX8"/>
    <dbReference type="OMA" id="EHAYISG"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="441"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="634" mass="68767" checksum="A7CCB7741C2B2707" modified="2012-11-28" version="1">MGLNPGSSQEPHGLSLPSRRAQITVTRRSSLQSQEEDDSVSPLGAAGAKRDSLEGTRRYYNVESPVMGQSASDTPRARTISNTTGPRPLSATPSETSFSNFRSPSRGSVPLPTPRGFLAPQKPAAARRLETRERYTTVSTTGLAPEPRTVGGFDATTPTGESDFSHISIEPPPAPPTTASPFSASASSSAPPRQAAAQRAASPTGPAPAASISVANDHSPAVTPRLSRIAPRHPDTPTRPGESIEGHAGAWEDDQSSPTHAPRRDLSSDHLVDTVRSNSTSTEKSPATLRKVSQKTYPDAPDQSALITTSTRRYKNFENKSSTWLCGGRLMTGGDSPVNFIGSIIIILGISGVWLGTTGAWLWVHGHEYGMAKGAGIAITIVFVYLFGLTVSSMIAASFREPGILPRQLDPDPPYTPVDVYWEANPREIRVGPDGKDKISCKYCETCKSYRPPRCSHCRLCGNCVEGIDHHCAYLHGCIGQRNYFSFIVFVVTAAITDIYIVVFSAIHFSMICHHEHVSFKQALQDSPGAAVSFILGILVLPPILFLFWYHIRLLLYNLTTIEQIRASASRNLFKATTRPYNPFAKSSRWKNIVAASIGRPQVPSWVRANDGVVDDRRAVNPALTTPEKYLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW07</accession>
    <name>K1VW07_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000327">
        <property type="protein sequence ID" value="EKD01043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW07"/>
    <dbReference type="HOGENOM" id="CLU_2160193_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW07"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854059" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="11514" checksum="61C831B0340C1CD1" modified="2012-11-28" version="1">MPRSLSDQLRLATLLGLALTLGAAAHEGHVHGTTSAAAAAATGHDMSGMDMGDGSMDMGGDEHMGAMTGMKMWVHGTIGDDSADDVLEVLLPSVRPCRSPLPDLHMDMAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW41</accession>
    <name>K1VW41_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="11" type="ORF">A1Q2_00902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW41"/>
    <dbReference type="FunCoup" id="K1VW41">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VW41"/>
    <dbReference type="eggNOG" id="ENOG502SDCP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1200540_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW41"/>
    <dbReference type="OMA" id="ICMELAN"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="24513" checksum="2B938C1DDEF1277A" modified="2012-11-28" version="1">MSTTDPAQQVGPRPALLLAVATQQHLLSELFTVLQATSSAPNADALPALHAGLVQSSERLDQLSAELKVHQAAYAEMLAKQKKAKELEDEIRSVIRELHGAKVDLEEVVNEGAKVRESIEQSEKDPVSVDQLIAHAHALAKTTSAPVSSLLAPVDKAAATPWPNEAAMRQGLLFQLEGSMSGVGDVGVVGDATAPEPAQPAPQVVHEEPGRRYDPGAVFQLDLNSDDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWD4</accession>
    <name>K1VWD4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein mS38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWD4"/>
    <dbReference type="STRING" id="1220162.K1VWD4"/>
    <dbReference type="eggNOG" id="ENOG502SE4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1031297_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWD4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="2">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="270" mass="29789" checksum="D729AE8D987186A5" modified="2012-11-28" version="1">MLLRRLNHVAEASVKPATRGRSRPVRCVPRRVKADLTPASSEPTHGRRLRRGAIRPMEISSETPYMAKPAWNPAPLYPFQAGLHMGLNGHMPLPVPLGVSHYAKKLPEAPLFEAPKLGNPLAELPKTSSMVGDHLAVTSALAHPALSSNLGSFAPRSFVVDVNADAHVASDLEKAAEAVKTQADFEWELIMSNLGAGSRRVAEVEKVDEAAMKDALAGLDGLLARMSVETEQDFEVSMDSVRRKRQKKMSKHKHKKRRKANRAERKRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWF9</accession>
    <name>K1VWF9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWF9"/>
    <dbReference type="eggNOG" id="ENOG502RB75">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401801_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWF9"/>
    <dbReference type="OMA" id="HEMIYSK"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="685" mass="73183" checksum="B2B9FAF08DCBF6DF" modified="2012-11-28" version="1">MPGSVHHLPPLSRARSRSSSSFEHRPLPDPVFPHTRGYAQPAAAARHQRQLEELDQLELFADTFSKAGAVAFLSHSPTSSTSSHTFSLHGHQQVTTAHRNHSPRKHQHSPSNQSSSSYQRQQRFPQKTPPSSRPGSRPGSRPTSPSRSAEAASTPSVPVPRPGSRSSRPGSRNRLVRPSNNNAPAAEGGSQPKSRIPTRPRAYSAPALDSEILTDENAPPLPNMSMTESYRLGSLANGTAGSPSHIPVLKSRIRTTSLARVPSPDLPELTDRLADVSPPFRVDLDAALAEIEDELEARANERFRKAQPAPSTPSPTLSTSPNPGARTPQGSGTKGSTTARTRTTSTRRQANGGSTGSISKANGTVTPRTPRTPNQQRTTAGVSRASSVGASPAEHTPRDRRISANGGTLNGRKRFGSDATPNSVKNGGKIPRPRTKARTSSASAVIPSPSVHPQNNTAVATPPSTVSRPGLAAHWVPPEPTFTPPKDADWDDVVLPTVAKKLGISTLSNSGHGRNQSIASALEVSQSSTSGEAGEDDLAVEWDRNGQPIRWEKQQPKAKRENIEMSPMRASMAATSEFGAMPAQSSKPPASAEMPSPAPTGYPYQPYDPGYGRSPNAQLQQPPANQIHHHFTPGEMERPRPAPVPPQQPMMPMTDSVEKPTGNTNKKNKKKRADDDVKGCACVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY17</accession>
    <name>K1VY17_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_00242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY17"/>
    <dbReference type="FunCoup" id="K1VY17">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VY17"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="InParanoid" id="K1VY17"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD05481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="33449" checksum="543E0E830EBA5551" modified="2012-11-28" version="1">MAFGERGGRGGGRGGGRGGFGGRGGGRGGGAGGRGGSFGGRGGGRGGAGGRGGPRGGGRGGAGGRGGGRGGGRGGKAGLGKKGAGAVTIEPHRHEGVYIAKGKEHLLVTRNLTPGESVYGEKRISVATMNDAGEEEKVEYRVWNPFRSKLAAGILGGLDAIHIKPGAKVLYLGAASGSSVSHVADVVGPEGIVYAVEFSHRPGRDLIGMAKKRTNVIPIVEDARHPQKYRMLVQMVDVIFADVAQPDQARIIALNAHHFLKQGGAIVISIKANCIDSTAPAAQVFASEVNNMRKEGIKPKEQLTLEPYERDHAMVVGIYERHSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYJ2</accession>
    <name>K1VYJ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYJ2"/>
    <dbReference type="HOGENOM" id="CLU_1660680_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYJ2"/>
    <dbReference type="OrthoDB" id="2576415at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="184" mass="18633" checksum="D6A5D02599CF2DB5" modified="2012-11-28" version="1">MAARVMMSAVREEAAMVSTEALAAARSTVTTEAGAVTRQAAEAAFNPLAAKEAAEANARNVVHTTEKSLLEAMGRGSPVPGHVGTPKMTSSTSTVGNTILGEVGAEASATLRETTVSESTIVGKVLEQDMGVSVKEAMTNAGETGVQAVTEQAVQVAEAVLDGKFADTGKAVLALKEGAPKAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYV3</accession>
    <name>K1VYV3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYV3"/>
    <dbReference type="STRING" id="1220162.K1VYV3"/>
    <dbReference type="eggNOG" id="ENOG502S7BF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1176135_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYV3"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26035" checksum="F00FB6366D2C9249" modified="2012-11-28" version="1">MVVTISNKGQNNYTIVGSSSSFHDPVKHWKLLKNGTTTKHKQALNAGENYTVPYNVYSDVPSSVPHFVCLPRSSGWPVFRINQATSLESKANPRFKPQDLGLTVWVDLKNGKETTRVTAYNQTISVQEPSSSSFDVAGILAWTLFLLGVVGLLWLGSLVYFGKNEAKRNKRRGDAELRASERAKAAAKAPVVVKSGYEEEWIPTQHIKVRKAGVTSDDGTSGAESEGKTRRRKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZH5</accession>
    <name>K1VZH5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="10" type="ORF">A1Q2_03520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZH5"/>
    <dbReference type="STRING" id="1220162.K1VZH5"/>
    <dbReference type="eggNOG" id="ENOG502QS30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390874_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZH5"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Spt20-like SEP" evidence="9">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="706" mass="77185" checksum="20C8522A0EB66693" modified="2012-11-28" version="1">MASASGYNYHRFARAVLKKARKWEPSLSIQLYPTYWRFEHSEINFLYDGPMKPFLMALRAQVIPAALIPFLYDIRPPVSFVDGCLVVEIQDFRKGPETRSRVVMRPAPETLPLTIDNMLSRRQERWDDNMTLELESRIMVSLPGQSPNVGADGQFRSNAHKGEEEDNELESIRKLLGAGTRSQAGAFQPNWSVLRLLERIKAHNKQKESEAAARAAGQAKQLPTGGPGGGPPPPTNEEKKKSKKKRPAAEAADDGEKKPAKKKKAAPKKHLAEQRQSAVSFLLLLNHTPILRSHASNTGVTEEVDFTRLSQALSELRIMGREQARLIDYLTVNQTKMHPPRCRHQPHHARTIGGLSADFGPSTRPIASLSSPTPSTSDTSTPRRSDDTAVMGTLGTKRRGLSSFLYHTSFSLFILILAALLVGAAWGLGEQAAKSSHASRWNLFALCVAFAALVSIYLLLLDPCVEIHLDARLRTGIRDSSAAALVGHWTSAGWNTRCLPGRLEGKEQDTANALRAMPRPYIPIKTVDAPKKVARHIQAEYARTTVIAHMSSPTTGGHPGWGKPGTEWDGVHFRSYILATVPTMQELLLPSVKLRRSDVSELVPAAKSLDPNDSVLPTFVASYVTLVQKALYAGEEPSQKDAHATQICLQVVKNLVDIKRKRAAGAGHAGAGATAAAGTRADIASPHAHFTSPPTALPGRMLEGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZI7</accession>
    <name>K1VZI7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZI7"/>
    <dbReference type="STRING" id="1220162.K1VZI7"/>
    <dbReference type="eggNOG" id="KOG3200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059836_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZI7"/>
    <dbReference type="OMA" id="DMYKLYL"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="106"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="310" mass="33506" checksum="E86265A455D50F0F" modified="2012-11-28" version="1">MSESPKEVRLDDLQKDKVQGLPPCAYYIRDFITEDEEEYLLRKRDAATEMEDGWKWEAYWGGTLSKNGVLLPEPMPEWLDSRGITERIDSLLDDAAGSSGGEHALGINQVLINEYAPGQGIAPHEDGPAFSPLVTTLSLGSATVLDLHHYVRPDAPSPPMIAVASEDGESGRAIAAVPLGHVLLERRSLFVLTGALYQSHLHGIAARTEDWVRAPQTEPPAEVNSTAAANGEGNAEQKDKKEGAAGETQPGAPVIIANADLLSPIPKTLVSSPEGLKYERETRVSLTFRHAKKVLKGGKFSMLGGALRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W050</accession>
    <name>K1W050_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W050"/>
    <dbReference type="FunCoup" id="K1W050">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W050"/>
    <dbReference type="eggNOG" id="KOG2313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_2_0_1"/>
    <dbReference type="InParanoid" id="K1W050"/>
    <dbReference type="OMA" id="FNDSYKH"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="149" mass="16141" checksum="9AC5A36E40F68A0C" modified="2012-11-28" version="1">MLSTRPPSLLKRLWLSTLRPATVSMSAGTQAQSASTAAKSAIRIPGPVETSMQQKLMEAFKPQLIRISNDSSKHSHHAPMKAIGGGSGETHFAVAIVSSEFAGKTQIARHRLVNSLLKDEFDNMGLHALSLRLKTPEEWEGEIAKAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W177</accession>
    <name>K1W177_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261305_0_0_1"/>
    <dbReference type="InParanoid" id="K1W177"/>
    <dbReference type="OMA" id="HEYHEYA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1293" mass="139770" checksum="B622AF10E0D202CD" modified="2012-11-28" version="1">MGNAHSVPNRGADDDLLSYLSDDDFSDGERSPDQSGPKLYVRPPRWWLAHPYHEYHEYAFVSPSPGHTARAAMAPSIRTSNRFAALEEALEEYRDMTSPKEEEQKPNEEEQKTLDGFFRDVLAISAGGRVPQRGSIPSFDPPSQPVETPAGPSAGPSNQNNDNDVAEDATADTSEGSQGSQASQASQAPPSTSSSQLLAGIQTPADFLRSVCQLFHSDGSEFESDSEFDSELLTAFYEWDNEGSDAAPSFSEAMAAVQDLMTGLTSLQTMLQDGNAVQAGESDAQDDNGDDEAEGDDDEEVEEVEELVQKVNQGKGKASAEDDTSNSDAEVDAPAPFETSSPGTPTASSAPVSDTPVHRTMSWEAFQAFSRFTSFANLSDAEEYHYMILFGEADREGRLQELVDMLMGHASSGSHVAETVNGNDGNDAVNEAAPATPGPSSAGTAGSEETVSAPSTLQPRGSPSKLKIKNGSPKPATSLCPAPVSSPTVQSVGVQTAPAPAAIAPQPATQPATQPATTTQPTQPSLPTPPSSGSSSSSSLSSTLSLTPAEQDELDDLEARLSRYPVALITRHAEAQAAQRIASLEAAVNAANDRALLAELRLQAIKEGHVPAEAWVMREFRRKRGNNNGSGSGSGGGGGPPGPGGSGPSGGSGGSGGCGPSQPKNDDDLNNNGNGGNGGDAPNGGGGGAGARTRSAQPWYPRSRAPQPLVDANDLPVVAPRRGRPDPIAPPVRAPSRPAPPAPARIRFPPGLSAADIQAARQQAGRPSLGPQLEITRSLAPHLPQVLYSPRELGDGFALPVPEEQRMFVSETPFPDPQPEEQGWRQLEPQAETRLTRQWIPQQVNGQLPLNQPERPYHAEQSSYTPVQGYRQLQAHPLQPRAPYAPYAPPPPVYVPPHLRPAPAPTAPPAPPPTPQNYLQPQPSARQRGWYCPQPEQRDYHVQRTEVPALVLPDSPVFSRGIDFTVPPPHDEFQREFDRGRPPSAQGTKLNAAARPFTPGVGLHSTAEEFVVPTTYPPKTHFAKSAQSAHSEQLDEEEEDEEDYENHGLGLYAGLSPACFRESPEIVAPRPRRGDVPSHVRRWSDALEREATDRNSGELTQFPTYRSNRHFNPEPAEPVGEQAKKRWRRPDSPAPFATFFPEDTREPARERRERREQRPQEEATVRAPRHMPRGPRPPRYQDQQQDQQQEQQQLQQQDLPPRFAALAALADAESRLNLSLAAMGANRTEKAKRPRSPLPETYSVPRSTYLVSREGELATATPGQEEEGEELRNDEEEDTVRPRRRRRRRGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W189</accession>
    <name>K1W189_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W189"/>
    <dbReference type="FunCoup" id="K1W189">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W189"/>
    <dbReference type="eggNOG" id="ENOG502S752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_0_1_1"/>
    <dbReference type="InParanoid" id="K1W189"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26615" checksum="C0F2BA1D18DB0B0C" modified="2012-11-28" version="1">MNRLQPLLRASQHATSSRVTLDALASLSARSFATSAAAQAGPRRKPVEVEVPPLRWEPESPEPYRNSNGLADRAPTHTLTIACSANNCILTFTDRIGPLVPNTFAGQAKKFKGAQRGSYEAAHQATVRMIEQIKKVAEEFRQRQEKNPEEEALALAGFFAPELSDFRTRRRLNEQTANDTDVERMYIRVAFKGLFGHGRDAAATAIGGPEGEDIRNLITRVEDRTPIKIGGTRARRPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W223</accession>
    <name>K1W223_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zeta-coat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_02700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD02983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W223"/>
    <dbReference type="STRING" id="1220162.K1W223"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369694_0_0_1"/>
    <dbReference type="InParanoid" id="K1W223"/>
    <dbReference type="OrthoDB" id="9995831at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD02983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="753" mass="82827" checksum="BCBC3AD6E58EBE32" modified="2012-11-28" version="1">MSYFTFASSEYDLPHPTLSRNQPRFYIHDRPAYSPAQASTPLVGGESLHSRHPSINNSMYSGASTPYHRGSFYGSGSRTSLAALRHALHHYRTYSDNPTTDPLTPSAQLPSVPRGQCPPPPPGARPENFDGTAYEQSEASGGPVSWDSDMWRIPGQPLDALIDIHRVLYRGSEFEEGEDNAAWSEHGKEVKRVIEQWFEGDCVYDHPLVRLSSRQSVLTHFALLQLLATAYVPSFTPSSILHHARSVTSYARRALLGSDSDDLAADQAHDIQVSPSGQVDEWLQSSGPQLIRRRNADPNGWWKLWDVSAECRDIGCMECYEGYHVALIDHSVISLTLFPSIIKPRMNSLSPNVSTDSLNSTYASRSYLHSIVASVLQEFDFLLHWDLPVSTIVEFNEVGKATHVRDVVDVRDVIDTFVPFAKRFNWLSRRLTGVLTSTIGSVAMALIPGHSVVIGDPIRILDETQAAKAKEEEESRAKIKELEAKPGMGSPVGLESHVDDGFYPCPSGVRHNSLGLEGVSMAPDVDGANLSLYNVTALLVLDSEGNRVMAKYYKPPHGLAAQDLNIGAGGPGMPGLQTLKEQRAFEKSIWEKTRRGAGDIHPLPPHVILSRTSTDLQFHIVGPLATSNELMLQQTLTAFHDAVSLLLRGQIEKRNVLESLDLVLLAADETIDDGVTSGLLERPRKSAGGVIGGFPKQAFQLTTRIILETDAAAIAGRVTRPRPDTTDIVINEQTLLNAYSTFKERVSARIQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3I5</accession>
    <name>K1W3I5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3I5"/>
    <dbReference type="HOGENOM" id="CLU_366085_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3I5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="762" mass="82963" checksum="47C5E78F80D0A417" modified="2012-11-28" version="1">MVGEVSEPSTKRRSEPEALDAAAAKRAKTDADKEAEGKMEIDEEVSAPQFEKGKAKDSTTAEKKADRQAGIKLPIEIIGRVFDFYYDLVHDGRQLDSFAWDEEAALDCRLPELVSRCPHLWSLSLLDVPVFKGFDAVVILETLRLAACVKKLHLELQLMNLAIEAPGHLLNAAERCSRPDRTVVGSMSDPADVIQPFGIEGQARDFRARPDEMSEWWSSVLNEQTCDGQRADMTPRALAQRPRYVANGAYPNPVPDEPASEDWEPYVPPELELPEFLKTSNGEWDVDAITKAEYAAMMAVVYCRDTGKRQAAARWLSDRPLYAVTGRTFEQVNEAEDFSGLPINLHDARKHLALKLRWRLLDHLRAHTPESLYLVFKDPAAACIAHEPWFWQSLPVPHVRMRIARGMDPDDAFSLESLATCVPARELRLSPPSSGGTGGGTVTFWKTTTSRRVEAYPLHPRTCLELVCNTAKDLEGLKVPEGVTVLLGEGDQNWRAVEPGVPSRAMSEEERERLVQAYREDYKRHFGGPDEYVSYGMVDEHAGPGEWGSDSDPGPWAEFGHEDDEIIGTPPPDSDDEANDIPEADGAAAGVATGAAVNGEPTPNGAGGGGSGSNVTAPPQPLLLPIQVHLQQEVQTLLHQFMAQMAHEEAQMATQRQARLATHNQFVQRVQELQAQLAAVEAMELTPGQAAAQAAAQDQLLQVQQAVAQNQATGGPAAQGEVLGGLGEENGGGEPASAAEQGTQPPSQPPADDNGEGSSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3K3</accession>
    <name>K1W3K3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3K3"/>
    <dbReference type="FunCoup" id="K1W3K3">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W3K3"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026578_1_0_1"/>
    <dbReference type="InParanoid" id="K1W3K3"/>
    <dbReference type="OMA" id="MYGVYTI"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="383" mass="41574" checksum="11B7269CED5081C2" modified="2012-11-28" version="1">MPVALTNARRFVVGLGLLLLVVLLWTASNFITNDLETGEDKWQKPFLITYLNTSSFAVYLIPVAWRYWKNGRRRSHEYRPVPADASPLTLVRSISPSPDSTTLSAIVDDAPAPLPKLSIRETAEIAAWWSAVWFLANWSLNAALALASVSSVTILSSTTSFFTLTLGRAFGVEDVTRAKVFSALASFAGVVLVTKSDAMSAHVVGDNRPTHPILGDCLSLLSAAFYSVYVILLKVRIGDESRADTQLLLGFAGLFNIIFLIPVFPILHYLGWETFELPPTSTAVTICIINMLITLSSDYLYVLAMLKTTPMLVTIGLSMTIPFAMIGSMFIPSAHTDSVTGLSVLGAALVVGSFLVLGWQGWNESKQPQEVRGLGIEAEGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W401</accession>
    <name>K1W401_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W401"/>
    <dbReference type="HOGENOM" id="CLU_855774_0_0_1"/>
    <dbReference type="InParanoid" id="K1W401"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="37578" checksum="5B5487CB9469367B" modified="2012-11-28" version="1">MKFYPQFMTSIIDSACPSLLLTLRLVSRWVRLEVDARLARHILQTKERDGTAFLDLQFGTADTPQRIMHGGRTAKVLDLDASALEDGIATYRNQPPERKRRAAVFVPGEKLLVRYHMRSLALGQRYMWKGARRSVHFVDTTSFFYGLHSREAAYVRDGEEDNETVFHVAYDLRPNSSWEFREFGVRRVHNRGLTLVFSPDPVAVIGEKACIVLLRVLERIVENYAETGDSVTLVGVEGWSALIPSPAQMRLDTRRGWEKGMPMQAKIEWWVQYRARFVPDKQWNRGKKEEPEMAVKCVSLEEWREELGSHVFELMMDPEAVYWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4A8</accession>
    <name>K1W4A8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBP-associated factor 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4A8"/>
    <dbReference type="STRING" id="1220162.K1W4A8"/>
    <dbReference type="eggNOG" id="ENOG502SDNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627292_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4A8"/>
    <dbReference type="OMA" id="MWNIRED"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="51852" checksum="17D05CFBC4CDFECA" modified="2012-11-28" version="1">MSNGVIAPSALSTGVPPRPSTVASPVPTPASTATSSSQTPMQPSTPVPAIGTPSPGVNQNGKRELSPDRINGAPPAKKPLLEESQGTPRPMGVTNPVVSTAATPTVAAPSAPAPTAPAAAPAAPQPTAAAVAAPAPTPANATAGGAAGTKAPGMLPMGKGSGIDLRAEEEAARRAQRSAVGNIKFAGNASRARHTDLFGEVAMRNRLNQIAHNMTVDDDAMRYLALAAEARHQPPMSKEAAGRPAKALWSQRITSDPNAVMQALMTANKEENKAHRVARTERNARETEMARAAAAAREREEAAGGSAPSPAVETNSPDERPSPGGAGSGASSAGSKPKEPTFQAAPTFGAPPPKKTGKGKKAASRDVSADVQAKMTNIAASLATGRKKYAWQSGGSGAFRPQVPSLLSGKRKAAEAAAAEAETEKTGKTDAKAEVKAKKPKRTISAPHRRDVDVEKKGDKAAKDDGALTLVDMAFALAHDGSGRGMGTPDQIAHKIWSQPGGPYGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5R0</accession>
    <name>K1W5R0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5R0"/>
    <dbReference type="HOGENOM" id="CLU_1462335_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5R0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="185" mass="19836" checksum="FA43FFFA65678B38" modified="2012-11-28" version="1">MRKPGCGGFAVISSADKLESASEIEASMGAIAPRCAVMRSRSFSIGQAIERRREVAIVSLAKFSSVRSSAYPSSALASLENSSHDWDCPMPMHDRTVAELCWSPVQHIKDLQRACALGVSWTKVDAGPGPSPIYFGVETRPMPLQRIVPRAPLHLSCVPAVVAQRPLEDTSTPVASDALAEMSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8Q6</accession>
    <name>K1W8Q6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VPS4-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000142">
        <property type="protein sequence ID" value="EKD05158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8Q6"/>
    <dbReference type="STRING" id="1220162.K1W8Q6"/>
    <dbReference type="eggNOG" id="ENOG502S7NV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088285_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8Q6"/>
    <dbReference type="OMA" id="DRHFANK"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20726" checksum="A9A3105EBE70BA07" modified="2012-11-28" version="1">MTTPLQNVYYERKTATARPCYICNRPTQTVLATIKTEDFLYTCDGHLSDPATKLAAPAQGPTQEDIRKVVSEYQAREARRTAAQAKKDDDKDDKKEEKKGFLGSALEMGSKLISGSPSEEGAKSPASTPASPAGEMTGVPSSNVTTHNKYALHRHIFEARRNELRRKEMNKKAKETAQGLPQVPRGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA67</accession>
    <name>K1WA67_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA67"/>
    <dbReference type="HOGENOM" id="CLU_403422_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA67"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="683" mass="73973" checksum="7BDAF691E6CC15B9" modified="2012-11-28" version="1">MPSASEILYQFLMKEFRLSVISFVFLLCYGSPVLRAYRFAMRDTERALYGVFFHALPHLVHWSLEGKFHLSLTLLVASLIKEWLMTSRDPAVLLQLCVRFFSEDQALVRSGWNSQTQHRRSATGASILAVAPPLKVDVLGRRSYKGRILSPSATVNTIVGWSTFQSGTTMRPLSSVLVAFAIFLLKLVLVEAHPIDTDASDKSKRGRRHRDHRPPLPFDPQLRFFITDWQHMLVLAAFYVVFETVRWLKERRSSNGTPAPDNGANGLNPPSSESESSALNSSSSSISSYSTFSSDSRLPIALQNPALATPPDAPGPRSNWDDDLAAIRCMLGRGPPPYIPSSAETADNQNDTHTQSPGSEGIGQSAPANDRHSSPETQSLDVPISASLNGSENIGSIIPESPKNGYVIGSGKAALMTDAGAPSTSEFDLTITPGNISSGVAYSSGGQNGTKPPTAYNSASDSGIKGILNTAQGKGDKQRRVRFWDHAAQYQTGRAVRPGSSVPRPNTTCGDSFDDSTATNAKTPVQDKLAQTFSGVSPSCFSSGHYPANGKSNGPIPPGEIMSSRPAPPVPDPVPRPRSGMQHRRTPCVSSQDDITGSHATATGSRPTPHFYDFAQAAEEEEKAVQFLAQSTIDVDPSPIASRPSCSESIREPWSDLSVLPDLPAHDNRREEFKERTLRTGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBG8</accession>
    <name>K1WBG8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBG8"/>
    <dbReference type="eggNOG" id="ENOG502RBF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2223166_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBG8"/>
    <dbReference type="OMA" id="HIFEVIQ"/>
    <dbReference type="OrthoDB" id="2585179at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="98" mass="10766" checksum="741773458C86FEE5" modified="2012-11-28" version="1">MPPAEIHPDRTYIHVTTNDPKAIAKSPSPGVGLEYRGPVGELDGEHVFEVTSADGYLAPDSRQWKREGPELLKEVKAIPGVQDVQPLTAKPRAKRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBV7</accession>
    <name>K1WBV7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBV7"/>
    <dbReference type="STRING" id="1220162.K1WBV7"/>
    <dbReference type="eggNOG" id="ENOG502RY6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502665_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBV7"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF7">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="542" mass="59917" checksum="66B69F66D1D77C4C" modified="2012-11-28" version="1">MNGPVTLPDDLEQVLTVVSTGIMEGHIKQIDALRERYNEQFPLVRSLANVFTSHYATYILHLERALAQIDEALLMAETIAQGGRRSSRRLEETQLGRLGKLLQSLEELAAERGEPGLSIALSKPFQRLLKYPLLFQNLLYEYEATLAMVDEVQKIVRSIEDEKSTNEEREKTRDAWARIDGFEKNKTLMAPKPNRLLVSESSAKATAATSERRAPTLKERKSHHRLSDILKGKSTELWVVRFTDVSLLCELIGTTTLPISTMSENREKSEKAARRMSSMSAMSRRHQSLKTRNLYKFVKVHEWHEARPTPSPAAAPRLSLGFPRRSTLGGVAENATPTKLPPSNSPTKDMAEPSPTRVPLKDGDGSPTRLQRSRHPLSEAGDDASESMSVMSFAFRGDARPAVRRIKPATGAGTKPTVRRSLGAQPTTAGNANAKFANRLREDVTVRPASRVRRSLPPAMALDAAPARAGSVPVGGKRPPWNSSTRPETSSMRDLPSTNPANRKMVRPRTSLGGERERERESSVTAPTAASVARRRNLGGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCP4</accession>
    <name>K1WCP4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_06335</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCP4"/>
    <dbReference type="FunCoup" id="K1WCP4">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WCP4"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009823_4_1_1"/>
    <dbReference type="InParanoid" id="K1WCP4"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
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</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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                <person name="Li H.T."/>
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            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1541" mass="153705" checksum="06D1D8E25007A6CD" modified="2012-11-28" version="1">MQEDGTFLVDVPLPWGERQAYKYVLDGEWMVREDEDKEWDPSGNVNNAPPKPTGTAAASEAPKGTAQPMTDDRSTDAAAVPTDTTAALVSTGATAQPAVSQTQSTGLSTGDKAAIGAGAALAGGAGAAAAANSTTSEAKKKKNKKKNEKKKAKKKAERAAAQAAGGAAPVDGDDDDEDDDDEGSAFTGTTTPATTSAFATPALDTSNQLGHDVPVTTQSTTQGVDPSARTLDSELQPVKETESTAPVALIKDETPPVALIEDEPKPVALISDETPAPAGLITDEQPAPAGLITDETAPAATSAPPTDSSATAAPITDSAVPTEAVKPPTTAQVDQPDQVLVAEYDSRDPSRNFDTGFSGAAIGTAAAGAAAVGAGTAYAANKSSQSDEQARAQAAASNPSVAAFREASHEDDVASAQTYVKREQEGVVTKTTTVTEIVYDHGDSYGDSTEALVEKREPSTLRGQTEVSTAVDSADISAADGTHLGQQVTVNRVADTQVLGDSGEQVGRQTDVSQVTATQLQNPDGSPVADHIQGTNVEAFKPADTHEHETISHRAAGAVAGAAAGVAALGGAAFAAVKNATGVDIAPEAAPEAKRRGIDVEHLPQVEGPSDAVSPVGTHPPEGAVNQLQEMVDGLKHPQSVPPTDGAAIIAGSQTTVPASAATAAPIDASRSQAVPAGSVATPTSETTSQGAAVAAPVAGTAAAVGATTVPTGSQQQVPYTGGSLSPETSVKKDTTSSGAVGTGTQAQSAQGADPTQTVHGLGNQSSSAQGPATTVHGAGAGYTGDETISRSVPGQTGSTGTAAAASTSTTGAASQPAQAAHHPDPTFSKTTYDPNAPSHTRTEIIGAAAAGAAATGAAVAGGASSGSHNYASVTRSNDGNSQDQRRKYDIEDEITGKTSGQDLTFKPASSYDQSQHSTIPNMDGQSKSSGTSGTKAGDAPNGGKGFNGASRQQSSNVSDSQPPIGVNNKDRSPHEGEDLEPRPPTGTYGNPTNQPQVKAEVFRAQDTDIPSQRQAAAANNRTVPAPTIKPIKGPVTTSSTGHGAGGTAQLFSSQDRNVMAHQRALEEAEAKGETSKNLSADDAMAGLSKPLSNTSDQKPHAPTEAKVGHSGAGFNENPGATEAQKHPGLTHQAQQQSGAHTGVGAVGSTHSGQSQPSQYSGQQQYPGSTTAATTAPISQQTSHQTQGSTVDAAGNIRSPTGEVVGSTTNNAGGEVGTDAPQRAAVSSDVATGAAAGGLAGVVGLAAKNVADGVNTSAAGVQSGVNSGVSGVQSGVAGVQSGSTAGLTGARDSVTSGIAGVNSSLQQGRDSVAASTTGVKSGVVGATPDGRTQLGAGSPQTPAPPAPSTSTTTASNTTQGGLAPPHHHHHHDKEKRSGSFSKRFSSLGFGKRSSVAHEGKDESYAASQRPASNVPAAATQVQHNPSTGATAVQKTAVDSQGNVAQHTTVAQPTTTASNAGTVGRTGATESAAGSEFGTVGKQHGSAITSSTATQVPSQSAGAAGGSDFLNKDPAAAQQHPQVKKKKSGFFSKLKHAFSHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH60</accession>
    <name>K1WH60_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulation of cell growth-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH60"/>
    <dbReference type="FunCoup" id="K1WH60">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WH60"/>
    <dbReference type="eggNOG" id="KOG3739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007847_0_0_1"/>
    <dbReference type="InParanoid" id="K1WH60"/>
    <dbReference type="OMA" id="RINDDAY"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="299"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="611"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="722" mass="79036" checksum="5D8076FDAA6B5A06" modified="2012-11-28" version="1">MAMITDTGYVLHAIRLSALRTTDDPLTPRIVTLDPTFGGNPYVQAMGLSDIDKWPEIKRALDSPEPEQEPGAPARRRGGAYSPGEASTPSDVAGAEPPRPGGANLRYTQTIMPGNRTGGLGMRVTGRRDDGRRRRRDPDSRPRADSEPEPKPPSLPLSPELRSELTSSSSVGGAAPSLMGTLYSGGAVPVEDLGDDLEVDVDEGSDVDDDEVDEELVPAPKRPTHMRQVSNFMMPAPPRRVSTIHEDDRRSSTEDEPALQFGRQPLHAPQKSALTALLNAHVPHLVSTGDGQAPASTPTQVNPFNSLYASVAAPPTLPSLSLELFYPHSDEPSEPVIVQVRKDATVEEVTGYALWKYWEEGLQPPIAEEDCTTINWGLRIVEDDGEVDEDFPALDRESKISKFSYGQFGIVKASESQRKQNEAMMPLIQRRPSRIIAEPTRPPVRQNSQPAGAAGPVPPLPVMPPVPVPAAPMPALARSPEDMMDVTEQLSSSRSRPTLLRVRVEATPSVAFTTTLSVPSDMYIADLTEVLVQRKSLQGPSSEWVLCLGNKSLALPLDRTVASLGSNTELALVTRRWALENGLGTGDRRGGDPNANIFKRTSEHMPPDLTAFTKYTVLRKTGIGKHERVLAIDGDYIHNRGFFDTMKTTSFHVTLVANVKLSGRAGGFKLYVWRDGGRKRYEFEAENGRIAAEIVDNIKELMREYQKPDRTSAYIRSSVHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHH9</accession>
    <name>K1WHH9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHH9"/>
    <dbReference type="FunCoup" id="K1WHH9">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WHH9"/>
    <dbReference type="eggNOG" id="KOG4347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003538_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHH9"/>
    <dbReference type="OMA" id="HAHFKET"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000051">
        <property type="entry name" value="Probable MDR1-Mac1p interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="275"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="696"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="762"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1054" mass="116820" checksum="E6231DF4669E5E3F" modified="2012-11-28" version="1">MSLPMHLRAYTEKTKDEQTRDFFNVPLAEQLPAPNATPVVVKPAAGRARSGSASGLQGMDINAVLSVEGKEDVYNACWRAFVAPCVMLVIIPRASSPFFRHSSASSPTTADHVAAPCHCTRSEELKGVFALSLATWHGMRILTSLLPTAEHFAVLLRDALKSQLAEMKALKGFLPSLYSEYLLGAGSATTPATESLIDVGGDAQQQSDEGDLRGPGGQGHGTYERGLGETFGFPGDARKMRERSKMKLWREYFTVHGRNMTLLRYPPFQRLLQVGLPSRLRGELWEVMSGSIYLRFANPKTYQLLLEQNAGKSSQSTDEIEKDLNRSLPEYKAYQTEEGLARLRRVLVAYSFRNPELGYCQALNIVVAGLLIYMSEEQAFWLLEVLCDRILPGYYSPSMEGTLLDQRVFESLVKRCLPMIHEHFRSVDVQISVASLPWFLSLYINSLPLIFAFRIVDCVLAMGVKVLFQIGLAILKINGEALLEVTDDGMFINLMRTYFSTIGDSAHPNHPDPRVRAITNFQELLVVAFREFNVITDDTIVTERRRLRAIIADEIEKFSKRAAVRNLKNVGRFNKEQVGIIYDHYFRAVCSPEAGPIGPVPAPAPGEVEQARITVDAQGRVETRIDLRGFKVLLAGVCTWAREETVTTNAFIQRTERRVADGEIIDRLFYSWDTQKLGTLSLQDVVEGLDRVMSAGLMESIEWFFQLHDKDGDGYLTKDEVIRLSESLLFIFRNEPGDIYLAAVSRFILNAYEFGDATAPEGSVPALADDPPNGENETATENRERSNSAAGPHNLPYLSLATFRMVVLADELLESFFETDLAHSFQLEDTEEEDYHKTHAKPDGLLGGLVNLVVNDDALGKHAEWRKPALSKADPNAPAPVEVRARESLLTPSQQEEQRRKRSMSQASQMSTKTTNSVSTTATTGTTGTTATETHTLADVEARYREESEMVRAAQEAVMHRPNFAIDAIGDSDGEEDETPEDDAGVMDEVEAFLKAHGGEDDTGLKGEERKQAEASIHDSLADINRPAQGRAHDETDGSVGIGRVTVVREVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM75</accession>
    <name>K1WM75_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM75"/>
    <dbReference type="eggNOG" id="ENOG502R9Q6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428401_0_0_1"/>
    <dbReference type="InParanoid" id="K1WM75"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="639" mass="68529" checksum="E824BD1D38893794" modified="2012-11-28" version="1">MHNQPYQQVPPSPAKHPHQHHQHQSSSSSGSSHGHGHGSEPLMTTAPMYAPFQYMQHGQPPHQQQFIQPDLGEIAPPDHVPGVQVTGATPTKLRSQHPSSDIPNSSPLEVSIEPYPSVMAIAPKLPSASSSAPSIPPKSTMGPRQRTAEDEEARKARKREMGRERQRRKRLRDKEKREAARAQLSGDVYQQFAGRSAGDRSSFTSTSSFEGISSSASFSNIPPLSMGFSPSQSFVSSASTASLSDVSSPGASLSPTMAGFASDSSWNEHTAVFSNLSLSGDGTVRASKHRPAHAFNHHNAPPLPTRHHASDNDDYGGYESERSASKRRKSDAGEVAVGLGVTVDNDDWSNTARRPRASRRTASVPDGAIFDVHHSDPPTLPSNFHQNVVRVPPSSTATPEGIFFASSVVAAVSASEWSAILQSRLGLTGELLERMGNDLAITYDRWRVEQGLNPVTLDQETRMSIQTSSPPVPTSPSSASFATPSQRHPDVMQQQASPPTSSRGAPAAPGTPQSQTQSKGHSSSNASPTNPNLQTPAQQQGVFPPQPFGGDGSWQSAAPMYDSDWRNQFAGKEQYGNPNVVIPSPGMSGPDFSAPRGAFNQNARGVPATTPLYYNPQFPQQPPVPGMRPDGQVFQGFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WML1</accession>
    <name>K1WML1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000290">
        <property type="protein sequence ID" value="EKD02364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WML1"/>
    <dbReference type="STRING" id="1220162.K1WML1"/>
    <dbReference type="eggNOG" id="ENOG502S831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515048_0_0_1"/>
    <dbReference type="InParanoid" id="K1WML1"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57070" checksum="39422809C34D4696" modified="2012-11-28" version="1">MSTNALFAVRRVLQHPSYFTPLRPPLYPRTTRALHGSALRWAVEAKKTPSAYATASRHPFAEGHGGGGSQPKKDEEGKDDAAKEKGELAGDPSDPGSRPKIGPFSKPVVDDAALEAPATETKSAERRDGPEEVKEAEDHHEHPELRTRTGPHSAPVEEEDAPPPVQKVEPPPPAPQPPAPPKPVVKGPATGPSSSPPVPLEVPQELAIPPLPPPSYFGPAHQFDTYRFVQKLEGAQVRNAPARVLMEGVRGMLVGRSRKAQESMLSQQELDNQAYRFKAALSALRTEISIKARNDGLSMRAASTAMQREVEGLDRKMTEDLQGLRHDSIEMELNTRKDDTRALMKRFDIATEEINNKFTISLGELRTEIESAKWEATRRAIAIIITLVICGVAISTFTSTLAPAQGPPPLPQVGTPNTSLPSGPSGSSSTSTSTSTPTSTTSGTGTSTGTGSKGSAAVKKVVYRDVAVGPDVTAEGEHFDADDEDNLDLLHDDIDALLQQQTTTTRRPRAEKAARVAEEKKRVEFPERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMU1</accession>
    <name>K1WMU1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMU1"/>
    <dbReference type="STRING" id="1220162.K1WMU1"/>
    <dbReference type="eggNOG" id="ENOG502SD6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128881_2_1_1"/>
    <dbReference type="InParanoid" id="K1WMU1"/>
    <dbReference type="OMA" id="PTHDMTQ"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="84" mass="9755" checksum="65A52655F32E81A9" modified="2012-11-28" version="1">MSSTRSLYRSLLREFRLALRSLVTSGGKDVDRALLEARDFLKAKRIHHELVKRYNPTHDMTQEERVAATARRVGLDKPEEFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP93</accession>
    <name>K1WP93_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP93"/>
    <dbReference type="HOGENOM" id="CLU_1355514_0_0_1"/>
    <dbReference type="InParanoid" id="K1WP93"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="202" mass="21905" checksum="55EB425498B4FD50" modified="2012-11-28" version="1">MLTDMCWDFGRDPAHQLPLGCGFLHSGIRELTSVCQAPSGTRALIDCQYLGQAREMGNELHETAQEVYAAHCKRAPYPNRACLPDDANQIGSAIFRDHLGAEDPSEVADLAHDDFRLLVDMLRDSLTKSQASPGPQTEICSPPDLDIPTKSSCTSGIAALVREGALNLLDARLVGILAPLDQLLFLPFRFCSEPLRLTGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WR98</accession>
    <name>K1WR98_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252650_0_0_1"/>
    <dbReference type="InParanoid" id="K1WR98"/>
    <dbReference type="OMA" id="HETTGQK"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1484"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1532" mass="145563" checksum="938C86F2E30BD2D5" modified="2012-11-28" version="1">MGITGKSDDPNAPKESLGQQIKDKLHIGDKHHTNTGAGHEGITSAHSGPGAAGAGGVHPSTTGAGTATGTGAGYGTTTGTTGTGYGNPHETTGQKALTSQDPNAPKESLGQQIKDKLHIGDKHHTNTGAGHEGITSAHSGPGAAGAGGVHPSTTGAGTATGTGAGYGTTTGTTGTGPPNPHETTGQKISDEASRLKGASSTGTGFGQKGVNDPGFDGRSGYPGEGVSGTHGTHGTHTGTGVGGVGTGTTGTYGHETTGQKISDEASRLKGTSSTGTGFGQKGVNDPGFDGRSGVPGQGVGGTHTGTHTGTGVGGVGGTTGTYGRETTGQKISDEASRLQGHSSTGTGLGQKGINDPGFDGRSGVPGQGVTGTHSHTGTGAALGAGAGAAGGYAAGHHGTTGTYGHESTGQKLSDEASRLKGTSSTGTGFGQKGVNDPGFDGRSGVPGQGVGGTHTGTSVTGTHGTHTGTGVGGVTGTHGTTPGYGHETTGQKISDEASRLQGHGATGTGIGQKGINDPGFDGRSGVPGQTATGHSHTGTGAALGAGTGAAAGYAAGHHGTHGTTGTTGAYGHESTGQKISDEASRLGGKSSTGTGYGQKGINDPGFDGRSGVPGQGVGGTHTGTGVGGVTGTHGTHGTHTGTGVGGTGYGHETTGQKIQDEKSRLGGVGSTGTPVGQQGLGTGPGVSGTDTRHGSHLGRDAALGAGAGGATGAALGHHGTHHGTTTGTGVGGTGTGYGHETAGQKLDDEKSRLGGKSTTGTSVGQKGVGAGPGVTGSTGPGGNAGVASGDVHHVRGADEEPSNRDIAPPPTSTTEATIEGGGEMRDSAMIGSQMIKEAEGRPVTDPAYSGPPRSTEGGHGAGTTTGGNPGTVGSGVHGSGQASRLGGTESTGTPVGQKGIPGAGTTGHHDSHVGRDAALGTGAGAATGAALGHHGSHHGTTGTTGTGYGHETTGQKISDEASRLGGKSSTGTGIGQKGVNDPGFDGRSGVPGQGVGGTHTGTTGTYGSGVGHDSHLGRDAALGTGAGAATGAALGHHGSHHDHHHGTTGTTGTGYGRETTGQKISDEASRLQGHGTSGTGYGSKGVNDPGFDGRSGVPGQGVGGTHGTTGYNQGVTGQHSHAGRDALTGGALGAGTGAAAGHHLGGHRDGQSTYTSDTYGGADSYGTTGGQASRLGGVESTGTPLGQKGVAGAGVGHTGHTSHHGTHGTGVGGTHTAGGAYGETPMQKFADEASRLQGKSSTGTGIGHKGVNDPGFDGRSGYPGEGVGGTHGHHTGTGAALGGGALGAGAGAAAGHHGHHTGSGLPPNTAYRQEGAYGESTGGKLSDEASRLKGASSTGTGFGQKGVNDPGFDGRPGVPGQGVGTGAHAGTGTGYGAGAYGSHTGTGATGYGHETTGQKLSDEASRLQGRDATGTGFGQKGVNDPGFDGRSGVPGQGVTGGTGAYGSHTGTGTGTGVGGTTGTGAYGSHTGVGGTHGTHGTHGAHGEQKEGFMAKLGDEASRLQGKGSSGTGFGQKGTTDPGFNGVPGGYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTX0</accession>
    <name>K1WTX0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTX0"/>
    <dbReference type="STRING" id="1220162.K1WTX0"/>
    <dbReference type="HOGENOM" id="CLU_030902_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTX0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="578" mass="63315" checksum="064D9C8020CAEEC1" modified="2012-11-28" version="1">MASPVSEPSDVASETSSAPKSPETMSEIPATPLASSSATSTSPGQEPPNRNISGLPYNAFARVTLDSLSPMLDLDFHHRDSTSDYRYRYNESTGSRQCRVQDCGNSGGIGLGFHFVGTGYRLNGGATTPKFATTPGFGTNDLTLLKHVRVNSVRGGDGLGWMSGLDVAPYTVSATFHDRDVVFENATIDIPLVVKGRHQLVPKLQDWATRAQVLSVVENNNLNPQVTLQQSSVRYELIAMEKASLLTPEKKLSFPYIENDMGGRTKWRLYKGPEHAVLYNMTELVYKIPHNTSLVEVLGPSGDYSYWFGGSECYAAVDPRPVWGQYNVLPTSISKKVANVSDQTLFLLPLAPDVDYTLHVGGKSHDTSCPISAIRSYPYEYPSQNSSGGGDSPQESAGSPTPSKPAGKSTTGLIVGVVLGVVGGLIILVLFFWCYRRRRKRMVQQSVRSRSPVRRFVREEDAGEILEYLPPQYSENWEQNGGSTPSGATSIGESYDPSLSSAASRRPLAAHGSGVEREGDISPLKRAYMRTFGRLHHPPNDAQRPVSLQEEYKRIVEHPKNLSNLSKHTMRDPSSKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUH1</accession>
    <name>K1WUH1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUH1"/>
    <dbReference type="STRING" id="1220162.K1WUH1"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_17_0_1"/>
    <dbReference type="InParanoid" id="K1WUH1"/>
    <dbReference type="OMA" id="AIANIMQ"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="185"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="295" mass="31708" checksum="F8D051A556AF4524" modified="2012-11-28" version="1">MRTVLIDSVVGMITYPVGRTDLNIVVTLILRTCCCGLSGCSVSIVSAAAPLSSELIEAFKKRVPQAVITQAYGLTETSPLITAFTTAEAAGHDGHIGPLLPSWEARLVDLDGNDVPVGERGELWVRVAVVMTGYHKNPEATANAMHNEWFKTGDVVVVHPDGFLQVVDRVKELIKFKGFQVPPAELEALLITHPKITDVAVLGLYDKNQATELPAAFVTTDEKINGPADAAAFDKEIQAWVAGRVAKHKRLAGGVHIVDSVPKTPSGKILRRFLREKGQADYDAKLAASGVQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVT0</accession>
    <name>K1WVT0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-xylulose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVT0"/>
    <dbReference type="FunCoup" id="K1WVT0">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WVT0"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="K1WVT0"/>
    <dbReference type="OMA" id="GAHFKKQ"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="254" mass="27661" checksum="FF2F49DABDC4C259" modified="2012-11-28" version="1">MPIEIPKTESLKDMFNLKGKTIAITGASGPRGMGIEAARGAAEMGADIAITYSSRKEGAEKNAKELTDKYGVKVKTYHLDTSKYENVKAFVDAVVKDFGKIDGFVANPPEAWDKVIQIDLNGTAYCAKAVGEHFKQRGKGSFVITASMSGHIANYPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFIDKKTQDLWRSMIPMGRDGEAKELKGAYVYLLSDASTYTTGADIVIDGGYVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY46</accession>
    <name>K1WY46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WY46"/>
    <dbReference type="FunCoup" id="K1WY46">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WY46"/>
    <dbReference type="eggNOG" id="KOG3750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001788_0_0_1"/>
    <dbReference type="InParanoid" id="K1WY46"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854786" evidence="9">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="278" mass="30371" checksum="C2704B8F1A68B2D3" modified="2012-11-28" version="1">MATLVLASLAWIAFTAWMFGAGLNDRIIQATGGECAVPLRGLAQRFGMAPVDALIADTGRQPQVHGDDVYLPLPNRFCQTTPLIEKNHPHLFNFLRDVHGVHERVHAALRLPPPRWSGGFDVSGHAFLLTLGALILASELAPSWRSALAKKAAGVRVLSNTNMRPTLRHRLHVLSTIAGSALVALWVWMLFMTAIYFHDPDEKLAGLALGLIAAFGVHLAVPRQPTQVVEYKVRGPTRRPSPKREDSVEAANKVIGDYEVLGDDGEVEVLDEHAVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0R5</accession>
    <name>K1V0R5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0R5"/>
    <dbReference type="STRING" id="1220162.K1V0R5"/>
    <dbReference type="eggNOG" id="ENOG502S4MW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306335_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0R5"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="910"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="431"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="913"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1175" mass="122086" checksum="A95299A92A138A82" modified="2012-11-28" version="1">MQPTLLSPRPSQRLEGFRLSPPWLPDTKCTQVEAAEKKKKVQSSQALASAADGSCGSWSGPGCCCLAACAVCPLPSPFALATARPDGASRNRTSHSLTFLLPHFSTSTPDQKSPLPPPPLSLPSSPPPSKRTPAWFGSDSESLPHRLLLAHAHAYASQLRLGYHRRVAHSLLPPSLYSLTHPLPTSSSGRLPLSIRPRSGAYPTNVAALSELEVTQFKKFQSNTMSVEQQQQQQHAAQEGSAQAQQAQAPTNAAAPETEAADLKSEVKSDANVAAVEAGVAALSIPQPQAELHRACAEGRLEDVRSILGRGLDALETLGKFINRIFASTSVVKGCADCLKTHRSISVPTFFTPPRSAEDRSCFSSSDFSTTPKNTPEVNSVRWLFPQTSSSGRLPLSIRPRSGAYPTNVAALSELEVTQFKKFQSNTMSVEQQQQQQHAAQEGSAQAQQAQAPTNAAAPETEAADLKSEVKSDANVAAVEAGVAALSIPQPQAELHRACAEGRLEDVRSILGRGLDALETLDVASGCTPIVLAIQDGHADVVRELLSAGAIVPPPAVTMDPTMLQVLGYSQPMYGVPPPFQMGPPQFFQPGMFPPNGGHPRGSPNGGSNGAANLPPAEVAKTIPCRNFPNCKYGNSCMFFHPPGPGFYPGGPGFAPNFVPYPPGAAPFFPGAQEFVPSGGAPAAEGSQPPAGEANAAPAEGSAAAPASETTQHDSIPAPSNHVGSALSPAFVPGAMPSDAPNGAPYPYANGGPMSPSMMPIPPPPMPSDPSFYANSQPQFQGYHPNGYNAHGRRQSFGQFANGGGKPFHGKKPSFSGGPKPWGPGGRMGGSSHLGQWKDGNPPPCAFFREGKCRNGEYCKFPHMDADGNDCRHPDVVRGIIPPMPTRPPPRHGMRMMGGHYDPSQRMHFQNKAAAAAAAANANGGDSSAEGTAAATPAGEEGASANAASPATPASEKDVSGSTASLPPKPSAPVTPVSRSASGPGVARVHANGVNSRAHSPNSAGARRGPRGYANGHANGSRSSSSGDKKPIPPQRVPRADEFPALGLGGATTPTERREPSWGNKTGSQVLQAPAPAKPVTPKEEAPATPASEEPKAEEKVEEKPVAAVEPVEQKEAAEPQVTMDSDSEDGAVIVSVSTTPNPEASKPKVSPTSAAAAVSFASVAGTVIPEAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1L6</accession>
    <name>K1V1L6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V1L6"/>
    <dbReference type="HOGENOM" id="CLU_245677_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1L6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1570" mass="171102" checksum="3257800989AB12E2" modified="2012-11-28" version="1">MKSDQQSPRSHSRRSSPRKSQRSGPFKSLRGMSSGMFSDERRTLRKPPTTRSARPDSTTKDILKPKAKTRKGLSQILGWKQDHGPSEAPPLPPLPPFAADGGLAPLTRPRPSAGPDPFRQVEGGATRLPAGSSRSRKTSETVRAMTAERHAASVSDEAQVAGSRPESSWIHSLTEYDVPLTGSTSEQPLAADELPSRFSSLRQAILPHSPPASNVRSPPSTSAGRKSLDKEKTRSRIWKAISTRSRRSTVKSQHGTDDKGTAGAATPAAVRRRQKSQTSAKSDMRTRSPQDKQSDAASRRLPKRKSLAGLFGVALKRSSDMLRMAPSSPLVTPQSSPKALRRLADAIDGAGHHLIAASAGSQPMDMNDTSPDTAAFFSRVGSRGVDNPQSFDDVSAATGHLDRLVHAIGQLSPTRRRQSTSPESKSTWSSSWKSGSLLSTSRAKSPAASPSSGRFRTPLSLAPKRSSGTATAVSPSPQSKVRDFMPTPPRSPLNRLRNVRQARLSIVHEQEERVRPSSSTFRSRASIAPSTASSSIQPRSQLGHPERDGSILIGVGAGTPKPDARSLEVPVAPYDVSDSPPAAASRASVLLSRSDDFGRATLYPRAASTIRRAPMRPASTSLSAGDRDSFDFTTELAGLESGTDRISFMQALEQSRNLDSMFGLTTAIDQRHKVTKCSPSIVKTSKSDFSLPLLVPLQPKEATTYRRKPKSSTAPFAGQPGFSLPRPTVTWAPPQLPLPPLPQAQRAERPQHATHHQKQPSAFSFMSLSSLGEPIEGIYREGHMSFERNFEGISDPPRLDLGSKESLADLQSLLNQADRSLRRQSSKRLRQTSSSTTDSHLLDPQTILSMLQPASRQTSIQSMSDRLHQNSSSTLSSVNEAEISVVTGPPIDMRKRRQASVYSIRGSKDSSATVVPSPTRGTRARIPSDCSSAFSYSRIERPTLGDRMFDRDRDCMLEGMSPVSPEAALGFRSFQEQERRHREEFDDTHPYSAEYFSRAQRAQMSSVTIDLGMAYGAKKRDQRVQSSSSTFDFGDCQHSQRGSSHSSCRASDTSEQTVRLSMSMPRVFHSRDSSVSSYETPYGGALNHYLEESPLTTISDRFTAALNAQGKGKLPEWALSADITGPNRTSVLRPKPRSITRRHRPPRLQLSTDNESLPDLISPGDTSTEVSSLFSLETRSSVPPSGVHPQGRLSSTNVEVQPTIREESSYGTIRTGSPRHPLDASHSPHDLGPMDWQPNSVEKSLPAFLPSSYHDIQLFLAQSQEAYRPLDQALPGQALQQKSFGANRPSVAPLDRGDLPPPETRYRNMRSSSDAGTDGPASALLTHFARDSEVLPNSLRNLERKKSPSPVEDSSFRSSVTDSTRRRNLGWRRKRHSEDITTALGRSPLGSVSESMIKKLGVNDSSRDRKPSTASVASPLPTFIAFTPPAPPKHGSFPSRRVMVDANGSPFAGWGDSLTALRVRTGDLSPLKHVAGKRQLTSKNGDDRDRAPLGSLWSHSGNAPKSKIPQPAGKDHGNHPKPRGRTKSKPKTPKIIPLKHEPLPTRRRVFADKENAMPRAPVARTVPRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3J3</accession>
    <name>K1V3J3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3J3"/>
    <dbReference type="STRING" id="1220162.K1V3J3"/>
    <dbReference type="eggNOG" id="KOG3067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330991_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3J3"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="866" mass="96945" checksum="83DFC50B109C80B0" modified="2012-11-28" version="1">MSESKKSVEDTLSSAIAQLEEEAALKKTIKEATEPVEDIVRQATAELNRLHSANVSQHEAIANKALEIVAGAHTHWASIATLIPKGEFFRYQWALSPMFKSLGEDVGELQLVSDDYLQGVIGMVNELLEVLGAFKLRPLAPQRIIMSLFNTRDRLREKKIKFKDKADKLKVLAKNAIERAHDETLAAQVYKLAENPERHAPCAAELFLFWLYCHDQLTFHWFGDDLTAWPALVKDYEEVGSWERSKRDAWWAQYLMDRLRLLTDTSHPKIPASVISAWGLDAIHDAEAAVKEELGPTLRSRSPGSVACILRSGSEWEFDITKGWIPKHVKFDWFLSRVQEAIIRSYTTHQYAEFPEHEWLAPQSKDKKHLRVAPPRKFGPAGAQGQTLILKYAGEYVGGSNAEDLRNRWAKFIFRYEEPKGSVKPRFLPLSFTAAAMVLDHNFDDSVALELNASFRCCEVYLGVDSVPLSNTHQTNCEYCPTNFPPFKSETAVKVNGATVLFLACIVLHNPQYLDHETAEPRDVSVDSLTIGRSEVFIRWQSKSTVFPVHVLLNEGLKLATPTVENSRPTHIILTRIAIVMGCVLGAAVSLLDQIIRKQTQQAQKLKSLSAVSLEWAEILLSAAPISGGGNLQLSFGAMRQCVEDWLDAKLDDATQGLRTAIVHMNELLLRRIHYSIELLYPKAPIFRRRVVEAYLACLHRTFLLTLSDDQSCDFEVREFAVSMQHSDHSTAEWTVNRLVYWGLESQSDLNKAIGVTFFAEDHNYAAAVMAFLAAGLNLPTEDSMNTVQLSERVSLTADDDEESSPPAIEASEGNTPSVEIETVRSLWFSSFCAGTGLTLAVIILLVTTRIGGSQSDHRMPTLDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V483</accession>
    <name>K1V483_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V483"/>
    <dbReference type="HOGENOM" id="CLU_1595723_0_0_1"/>
    <dbReference type="InParanoid" id="K1V483"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="167" mass="19369" checksum="5326D44FD29B6A44" modified="2012-11-28" version="1">MPPSRTQSPNPTMDILSSVRRIDTSLKTQNHSRYAVQHELANLREATTRMQQLLYKSVKYMMERNTFASNLEEVKIDIDDTTAKIRELQEKEKAAKNEGTPEAMSEFNTKYGETLEEHIASLKKFRRQRRVVLKELKKLDAKAEKVVESCQKVLGDEEATRTARHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6R8</accession>
    <name>K1V6R8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6R8"/>
    <dbReference type="HOGENOM" id="CLU_1533655_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6R8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="175" mass="19784" checksum="E1705EB72331F7CA" modified="2012-11-28" version="1">MFRSMSIPSARYKGRQSGHSFVPPSIKRIVSHRAERENERRSESEESYVDLIFHCFNQSLTDNKNATGKMGKYLTAPVSLKAGSRHNAAVRASRSRVRSPKAFLRGARRCSSIKSSKTLAIGRETIRPTTRSLGPSLADLYDDSDSEYEYNPEDFSESDFDPSEFSDGDFQSNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V721</accession>
    <name>K1V721_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuole protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05873</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V721"/>
    <dbReference type="FunCoup" id="K1V721">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V721"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_0_1_1"/>
    <dbReference type="InParanoid" id="K1V721"/>
    <dbReference type="OMA" id="ENEDFWF"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="791"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="972"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1145" mass="124849" checksum="77D3BF256BFBE447" modified="2012-11-28" version="1">MPARDPAAAPHIPPPLSTTPPGPGLPTHYVGGSGSGRARSGSSAGAAGMYRELSTSPSTSNRRTSATLGIGLPNPDQRARRVSQGGDSRVSRLFRRLSATSDHSDGAHGHHAHHIIDPVSGVVEDAICESEFEREDDALDEAGASTTSRAIRDSTHRLASMSVQTSGYMSSGFQLDHRPHHPSPLTSYIGSTVDFHGTSPSSSRHFKGPESPKSGPSGLSVLMERGRAGLGTSQRSQDSEDSGDTTPHARPRELSPEVDPREAQLDYRASHLAEVQEVNEEIEDDMGNSSEFRQYLEAEAARPPNEQTPLLADRKQGWRSRTGVDFQVARNRFSKITLTEAVRLCITEPIHCLPAVILGVLLNVLDGVSYGMILFPTSPYFPGFSSLGISMCVVSQLVFSAGGSIFGGGNGTMMIEAIPFFHILVNLIVAEVGDDANSIVATTMAAFAFSSILTGLVFFLLGACRLGSLIGYFPRHILVGCIGGVGVFLILTGFQVAMRLPEDGFELNLESLKLLFSSVHTFALWAIPVALAILLRVITHHVHHQLVFPVYFFVLPVLFYIIVAIGPWSLDDLRHAKWIFEVDPDPKPWYEFYTYFSIKNINWEAFWGVMPTQLALVFFGILHVPLNIPALGVSLCEDNVDLDRELVAHGFSNLAAGLTGTVPNYLAYVNSVLFYRVGGGSRLSGFMLALATSGIMFMGPGAIAYLLWDTRHRVNRMEYITIWVIIIGMTVFDFVIGLFIGIILACVFFVVQSSRRRPIRTVFSGATAKSTVRRPAAQRAFIQMVGSQTYVMKLQGFLFFGTIAVVEDEIRKLLDLAMWENNPIRFLIIDFALVGGLDFSSAEAFVRIQRLLAAKDVLLILCGAEPHGLVGTALRAVDLWADEDGSQVEVFRTLNDALEWTENAYLTVFYDNKARQRPSLQATEARGIDLPKMAKVPFSLAESFQNSPRRTLLARAGDENLHSGFVTYGSTLAPPAQSPKSPPAAEEHHEAPRPFGQPLQILLQTLGPYTDAGTEFFQGVAPYFAQVVVETGHVLWRQGSASDGLYLIESGSLRATYAFDEHAEAIHETMVAGTVAGDLSALSDTPRNATVVAERDCVLWKLTPEALEKMQKERPEDASRLTKVVLKGAVEEVDVLSAHLIAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V911</accession>
    <name>K1V911_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V911"/>
    <dbReference type="HOGENOM" id="CLU_837256_0_0_1"/>
    <dbReference type="InParanoid" id="K1V911"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="331" mass="34853" checksum="BB7431EB08847AE6" modified="2012-11-28" version="1">MTSRETPTPSLTSSIGPATVTTKEHSTAAQHLQTKPTNWPSGNGQLVARQGGVRIPQASLSSEDDAERTVTGNDGLCVYDPVLNMSWCSGFVSTAGRSSTRRSSSSGDDLTITEVRTYYDYSYATITETFTSTTRSSSRSSSNTRSSSARSSSSRSSRSGSPTSAFNDAPPVPAPLSPKARAGIAERFEVDESLIVTPHTETAPRPSEVERPLSAAFSTLSCDTNRPLPALPLVDGTRPLGNEMREVTTPGSSSLSASKVLAAAGSSSMMPKTIASSTSTAKIPPGNAPESVISPVHPSAVDDTDMDAPPQYDPRWSAERSMLSSSPMMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9Y4</accession>
    <name>K1V9Y4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9Y4"/>
    <dbReference type="STRING" id="1220162.K1V9Y4"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_3_1"/>
    <dbReference type="InParanoid" id="K1V9Y4"/>
    <dbReference type="OMA" id="FRDPTIC"/>
    <dbReference type="OrthoDB" id="2594284at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="214" mass="23924" checksum="ED33E28CC03CD292" modified="2012-11-28" version="1">MSATKLKILCLHGFTSSAARLSRQLAPVVQASAPWANFTFVDAPFAVEPGYAWWRAQDRSGPDGDYAVYEGWPKSRTYLHDILREQGPFDGVLGFSQGAVVTSLLCLMPEFRDKFGFGVIIGGFKARDPELRRNYEESNPGFDRRSLHVWGREDDIVPPRASEKLSEMFKNPELIVHSGGHVIPTAEEEIGKWTAFFRERAGAKAAREGSKAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAB9</accession>
    <name>K1VAB9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAB9"/>
    <dbReference type="HOGENOM" id="CLU_874894_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAB9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="318" mass="34641" checksum="BF6B5A32F64C59B3" modified="2012-11-28" version="1">MLIPRPVPSKLLPTVQIIGRSDKTFTPKTHFLDSNPFSSLGVNRREFEARSGLSLVQVAIWSAHASWLARKAVGLNVDWDLWEFGHIAPPPDELLGAHLLPASSYADSVPPERPQAPTPARGTASGSDSEPTSYNWFLGEQGRPRELDLLDSPTSTYSDFSDASNEYLQDLVMTPPQPKRREPVSLADIRAFGSWQLDGVPSFGSDLNSPTKLRERMRRRSENVLGRPLAEDPSPSPRRNCKRGTYSGLGLGFAEKVSFRTAHSSIVQLGTTVKACNTSSWSESASSSSIGETPTRSGGVALPLTGVSQRTQPKCLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAW9</accession>
    <name>K1VAW9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAW9"/>
    <dbReference type="HOGENOM" id="CLU_1138695_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAW9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="244" mass="26920" checksum="68816C26524FF99D" modified="2012-11-28" version="1">MGLKALCMSFHRLEAPRRGLQDFSQIAIPRASSDSRLSKQHKRSVSREVHDTIAEESEQELAALEEGRLAPPKASRSGSEASTKSTKSTKSTKSTKSSSDVEYRGVNRLGWGAPNAHPVAAVDVEPNALNREEVLASPHEEPFTVYPPEYFAPVAPVLDAESAAVRPGRVPVNRRYGYIADGQAGRGVRSPTRFVQDNYTRPLTPPTRRASHQRSLSQANEDAAALRSSRTESWHSRSKSWDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB56</accession>
    <name>K1VB56_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB56"/>
    <dbReference type="HOGENOM" id="CLU_1416102_0_0_1"/>
    <dbReference type="InParanoid" id="K1VB56"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="192" mass="21916" checksum="0D260F77A45B58E4" modified="2012-11-28" version="1">MSDHAVLGAIVTDEQSVTGVLGSRPTHIPSELIMITLVLLPNGIDGTRLHRSSGCVASFHAQLTVERSRFSQIFRKPPEALLRDLVNEGFRYDDCVTAAKLYSSKEAAVIYLEQLAQHREHEKLVLFLRRRGFYRPHCEKALKLWPDVMDALRYLQHQQHERKEGCVFCDDPMKLEGIPQEKLKEGVKLKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBK1</accession>
    <name>K1VBK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CnHHK4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBK1"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_82_0_1"/>
    <dbReference type="InParanoid" id="K1VBK1"/>
    <dbReference type="OMA" id="PATIAVW"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="654"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="930"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="1245"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1559"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1476"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1169"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1505"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="978"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1694" mass="186107" checksum="99D46FB4D00B500D" modified="2012-11-28" version="1">MVASLWVQDLVDQPSGPSRQSYDDIPIQFFEQAYPFPVLIFELPAGAVRFAEATPANGTQQRSGPSSNSQNKGVERRPDEATAVEGCPLPDAALKWANHHWRNLASERPLSDFLDLKSLEQLSSWATDGTRPTTFTLQCGSPRISLSLTKSHIEDPEQVHYVVVTSQLLGFEDSSSGSTQSSDTAIVLGREDQEATPMPPPAPSLMSPPSSSAATLGLGPESPDFQTRGPSLVAGHEVKHDISDVPRTMEPKAHEHLTDQYRISTTELEADNARTSCRELYNNMDWTGKPCGPPETWSPALRALVDIAFDTVTADAVYIGTKPSDLVSIYNNNYGKFLDHPNTFGALMSEVWKDAWFFFEEMGKPMYQDFTLIPYLLDERGVWLEKYHSYSCHPIYDGPNIVGVYVAAMDWTTEVLTRRRAEVTRALADSIGIVRTRADLFQATAEDTVKLSLESTVGVPSSHRSAPSSLVLEVPRMPKAPRSATYVGGYAEDDGTFDDESLSGSASTALNIEESIASGISLASSRSSDRWPTVELDNGMWPIRLALTTRRCIRVENIRELISDYPLRQWDELPDSALVIPLSSDVSVDVPSAVVIVGLNHHSAVGDRGYANFIHNLRAHLTSALGPIIALENEIARSEEKAKMERAKTAWFRGAAHEFRSPLSLIAGPLEELSTGTDGMSSRQKEIVTLAHRNVTRLQRIVSSLLDFSRMEAGRFQARFTMTDLGAFVTDLCGLFKPAMRHPQIAFRVEVEERTDNVPVDRVLMETALANLLSNAIKYTKRGSITVKLWYDADNANLSVVDTGIGIAAEEVDMVTHWFHRSQAALASGIEGTGLGLGLAKEIIGLHHGELQVSSNVATGEHPSGSTFTAQIPLAQDVVEEELTPVAFGSYGREMARDVIGWERDESGSVGSQESSPSYGEGLQFQPSDVLLIVDDNRDMREYIKLIFSPFCRVLEAEDGVDALRIMVHETPNLVLTDLLMPRMTGMDLLAEIRKNPNTSHIPVILLSAAQDEESRVQALLYGADDFLSKPFKPRELLARVHLHMEMGKNRYDLETKFHERELELQVLSDACPSGIIRADHSGRVLYANPAFLEPAGIAADSELEDWQEHLDESSAESFRFAWNDFIYGKRSETAIRFKWRTGRSMLGFFIRLDKASGVSGIIGCITDVTYEEEKIEEAERRRAEAEESRRQQELLVDLKNLRARRDRLISSGPEGLRPEPSMLKEIEEDIKALESIYHCGVTQERIASDILSLARLQLGMLSVHHIPVDIRHEAEKVLRVFHSECKMSQIDLRLEFGPGFDALGDVMISTDPVRFGQVVTNLVNNAVRFVSVAPERRITVRYDVSRTGPLEGDTVPPSASALEPNGTLANGTPVWIYSSVQDTGPGMTETEQSGIFERFQQGSKMIHTKYGGTGLGLFICKKIVGLLGGDIDTVSAPGQGSTFRFYIKSVVVPPEHSPRPPLPKKLSGEQIVSPLDSPEEYRDGQLSPVLEGVPVPLSSPDAPSTTTERTSVSSTGRGSASSADRASATSADRGSLYTKPTSVSSTSSVTSLDAMSYSILVVEDNLVSQRVLQRQLTKLGNTVMVASNGQEALDTLVAQQGAFDMVLMDLEMPIMGGLEAAQIVRLLEAEGKLPPQRIIALTGNAREEKVQQALDTGMNNVMIKPYRLPKLVGMIQATIDSTPGHTAAHNTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBU7</accession>
    <name>K1VBU7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBU7"/>
    <dbReference type="eggNOG" id="ENOG502SCUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107764_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBU7"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02224">
        <property type="entry name" value="cupin_SPO2919-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27547" checksum="DB4F8D541F0B7884" modified="2012-11-28" version="1">MSASSSKGKGKAVTVEEEHVHGPNCSHSHSHGHSHEEEYDHFEGSEEIQDPVVKAADIEAAMETREHFMDGEVQRVQCCVSDMVRLPQLHSAMSRAELIEEAVQCEFKLTYAAGMSESGLAVHKVRLEPGRESTVLHSHLAESEWLYILQGTATLRLARPVVADEGDIRPPFGAELIEENREVSAGDFIGFPAGNPNERWAHTLRNDSAAPVEYLLGGTRLNLDVISYPAHGKTLVTHEGSGAEGMFQDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBY0</accession>
    <name>K1VBY0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBY0"/>
    <dbReference type="FunCoup" id="K1VBY0">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBY0"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396993_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBY0"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="ZN622/Rei1/Reh1 zinc finger C2H2-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="694" mass="77612" checksum="2452B52869BC6A80" modified="2012-11-28" version="1">MFTCISCRIAFDSAEEQRSHFGTDWHRYNMKRRVANLPPVSAAAFNEKVIERREQNAVRPDPRDMACSACRSHIQSKKHREREAAVARGANAPTTKGPGSVALQDQDAAMKSEDGMDQHSDDDDDDDEEGIESAIAASRRRLPAGVCLFCNHRSSSLESNLVHMSKQHSFFIPDQDLLIDLPGLIGYLGEKVAGGNLCLYCPNGGKEFGSTEAVRKHMIDKSHCKIAYDTDEDRAELADFYAFEGPMDDEEASEWEDVEDDETWIERTRPSHGTDDPVKSKVAMIRQRLADPSSALVPVAGGHGAFGRGLEVVKARNAGEAAWAKKQGRSFRDQRAREAFKTKVGFRNNNQKRKLRPCEISTDAHRLPRPIALIAVVPYAVPLCSLSQMRRLASVASPKRPLFSPKARRRRLIEEGIMCFFLPLLMLPLLYIVQGHRYDILEGLGPLMADMNTWPSSVLRYLTTVLIALGSFVYAGERPENHLSPCPAYRFGSADRQGLAVYWFFKSRSQFRSILSGSGLTTGRYFRLAALAMSDSVISLFLTLFNFLVRIVVYHTGWTPYVSWAWVHDNFDLISQYPEEARPNDNFAILQIAVPFYTVCIYAIVFFAFFGFGEEAIAEYLKLWASLRNWGNPSGATKIESFRKPSLNLGSTVMTLSGSQVPDIERSGPMSTTRLAPADSSPQHIAMRIEQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE29</accession>
    <name>K1VE29_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE29"/>
    <dbReference type="STRING" id="1220162.K1VE29"/>
    <dbReference type="eggNOG" id="ENOG502S86Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721960_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE29"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="383" mass="41209" checksum="7E41CA4A9FCE2B3A" modified="2012-11-28" version="1">MSEQPERKKRRQNVACDSCRLRRVKCDMLALLTPKDGGPERPLHVLVRENPDVSCTNCVSKGIRCTTNQIVNPAKPNKGGKRIEEAKKMFGSDGFQNTAPTPVPQPQARRASMPRSPSVATPGGSSGSSVPPNPPAMMPMFGGHQFNMTGHNGHPGPTASFVPPAPIPSPTVHPVHGWSAPPFDDWTGLAFEAQHGVAFSHPMHAPPNALELSTWETAIVVPPPPPGHAHSLPVLPSAMGSRSVPPPPLEPLFHSPLSPPLMTSSSSSTAAFLPAQSLTASPGVNSDACLPSQPPSRSDSGQSGQQPRVAGRKRTISEHEDDDVLELVRDDEPNQLDPSYMWAPRDKVMRYPQFRGLQEHPAAQPPRPGESHHRPSSSRRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEC1</accession>
    <name>K1VEC1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LEM3 (Ligand-effect modulator 3)/CDC50 family transcription regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEC1"/>
    <dbReference type="FunCoup" id="K1VEC1">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEC1"/>
    <dbReference type="eggNOG" id="KOG2952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="InParanoid" id="K1VEC1"/>
    <dbReference type="OMA" id="TWNNDQP"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="399" mass="44601" checksum="8EDED4E6A5B7C375" modified="2012-11-28" version="1">MGLFKRKNRNNDNLQSEDTNNHDAPKEKVKWSKRPANTAFKQQRLKAWQPILTPAAVLPTLFIIGIIFAPIGALIIWGSGKVTDITLDYTQCDADAPTDGTFATMPKGAYSYSLKTGSHIKASDIPPPKWSFSNVSSRPLGERAQCRIQFDVPYDLGPGVFFYYRLTNYFDPDQLLGKKRTVSQINDGNCKPVTSSGGKAYYPCGLIANSYFNDTYNAGKVTLLNPSNGASNETYQFSEKNIAWHGIAKNYVDKPYGNITDYLPPPNWHEKYPNGYSEDNYPNLEADEHFHVWMRVAALPTFRKLWARNDDDVMKSGTYEAVAMMNYPVKQFGGTKSILISTVAWVGGKQPFLGWAYVAVAILCVVLAIAGLIRHFIKPRKLGDMSLLSWNQPQAAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEH8</accession>
    <name>K1VEH8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEH8"/>
    <dbReference type="STRING" id="1220162.K1VEH8"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="InParanoid" id="K1VEH8"/>
    <dbReference type="OMA" id="RIWKFEK"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="30615" checksum="2CFDA7939CFF3967" modified="2012-11-28" version="1">MSKLSIGSTLTLNSGYKMPLLGLGVYQARGDECRDAVSTALRLGYRMSIPQRGQALSGSGLQRDAVFVTTKFMPGHDVPKSDDVYAQLRRSLPRLQPETPQDEAYIDLMLIHAPRPNAEARTAEWAALAKGAKEGWLRSIGVSNFGVAHLKALPGPVPAVNQIELHPWCQQRDIVAYCKEKGIAVQAYCPLVRAQRAEDPVLTRIAKKYGKTWAQILIRWSLQKGYSPQVKSVNEWRIQENAEVYDFELADEDMAELDDCDMGAEGACSWNPVDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGL1</accession>
    <name>K1VGL1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGL1"/>
    <dbReference type="HOGENOM" id="CLU_1289764_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGL1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="197" mass="21993" checksum="61EEE7B3BCF5D189" modified="2012-11-28" version="1">MSFFKNKLSRGHSMRVPADERPPRMKLSSLLPFGSSRRAGRPVSPLSPLSTGGVREAASAASATLRGGLQRKGSTYRQTYHHLDADQEPPQEWAPVPLQFVQDDFAYYSRDWNHYESDRRYNAPPPKPRMPNEDSTMTRSSSDRQLTQLGSNNPFNPHGTVRRAGGEARAPRVPPPKPVWVQFEDEWSSASSGSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH40</accession>
    <name>K1VH40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH40"/>
    <dbReference type="STRING" id="1220162.K1VH40"/>
    <dbReference type="eggNOG" id="ENOG502S0CB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH40"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29722" checksum="B937F94AC5242782" modified="2012-11-28" version="1">MGLPKNLSFLRFGTGGQTLDIYLDPLCPFSYKCARSLTENVLPQVREGGKYAGKLQLIIRPYPQPFRSAASTQFHSDLGVPVSSPVAVSSEQRAAWNTLAAVTTAWTLGRRSRHRDVQPVKLTCSHYFSTYPVEALLCFGADHPEQWWDYLLGVFSVQESFFNKPVHDKTPAQVQEAYVKVAEDVLAKAGVASAKEDGKKLYEQLQVHQKENGGSVMFEPLKYLIKEGRQNGIHFTPTALLNGLEDGSVSSGWGRSEWDKWLEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHC8</accession>
    <name>K1VHC8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHC8"/>
    <dbReference type="FunCoup" id="K1VHC8">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHC8"/>
    <dbReference type="eggNOG" id="KOG3380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101888_2_0_1"/>
    <dbReference type="InParanoid" id="K1VHC8"/>
    <dbReference type="OMA" id="LWHEKAF"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="17138" checksum="7836908C60E49196" modified="2012-11-28" version="1">MSNEYAFRKIDIDALEGDILLPSDLYDPDPRGPDGALADAQARSQESRGQVSRGDIAGALQTILTDPPYGEGVDQAKKLTTDAVLMILNSTRASDIPTVIKGLDQEQQSRLMAYLYKGMSALGQGADVSGSVLLTWHEKLTEVAGVGCIVRVMTDRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHS2</accession>
    <name>K1VHS2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000244">
        <property type="protein sequence ID" value="EKD03635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHS2"/>
    <dbReference type="STRING" id="1220162.K1VHS2"/>
    <dbReference type="eggNOG" id="ENOG502S69X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411138_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHS2"/>
    <dbReference type="OMA" id="CAKYERD"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="668" mass="74198" checksum="845285ADB5AF6C70" modified="2012-11-28" version="1">MSGDRSQAQALYKTGRQLYGEKQYAEALSNFDRALSLGDRSWKVLDGKAASMNKLGGPWQKSALEVARASTKKFGKEVHQTWYRLGIICAELNLLDEAEVSAKQGLGFCPPSAYDQYYLLNSKITKARQEAAKAQAKREAEDKEEAKRAKKRRTNYTHLLNADVLLCIAEQGLEVDPHMGLRLAGVCSAWRNVVLSHAPLWRRLVLTRRRPVAKLAMFVERGKRLTEVTLRYPVDDDRLARELRPQMRDLERLTFDGFSFDQIVRFTDNWRGVCAHLSDLTVKNSGGDRPTTKRPLFFGLLDPDATSLRSADVPIGNTAVYAPQDVVPLYGSREWLPRAEQLSHLRRLRLHSADLHMTLGSLLALMPALEWAELDVTAPLPHSTERTDLPFLKHLHLGNQRALNLNHTSLPSLESLSLYRSGAQVPSLDLGRFRSLTSLDVGFCYIGTQFVDLLRQLPKLRFLGLAGCSIQTDLLEHLVVTQGKPALLPELCALSLAANDEITAGPVRRIVLSRNLGALDNRPKPQAPAAKSPFAPAAGPFAPKRPKGQSVSRSQSSNGSKALLRASSITALPPASAPPPPSTAAITFLILDHCQHQYMDTGVLHGLKRYVGFVSFGNPPTVSEDRIRGRGAFDWTKVRSPTSECYLKKREAEDSWYVHHNCKMAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHX7</accession>
    <name>K1VHX7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHX7"/>
    <dbReference type="FunCoup" id="K1VHX7">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHX7"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_1_1_1"/>
    <dbReference type="InParanoid" id="K1VHX7"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="582"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="704" mass="78789" checksum="A89B92C204303106" modified="2012-11-28" version="1">MKNLKKAMLRTKSAGSDGKTKQPTKSSSGSSATPAAPANSAAATPNASESAGSSTTGAPLTPRRSPVSDKTAPAPPLVIISGAPQQPAANSEMPADPIPHSPHNRSFGSPDRPLGPDGQPTPPKAGNPLNRLRGPKDTIPIVGKTPRKQRSSRFHVTERVDIEKLAGFNEVRPEDRNDLFIQKLQQCRVVFDFNDASLELRGKQVKAQTLHEMLEYITQQRGVITESIYPEVVGMFAANLFRSIPPQVNPTGDAFDPEEDEPVLELAWPHLQIVYEFFLRFVESPDFNTNIGKRYIDQQFVLSLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAFIRRSINHVFFQFVYETERHNGIAELLEILGSIINGFALPLKEEHKIFLTRVLIPLHKAKSLALYHPQLAYCVVQFLEKDPTLTEEVILGLLRYWPKVNSPKEVMYLNEVEEILDVIEGSEFAKIMHPLFSQLARCINSQHFQVAERALYYWNNEYIVNLMGEHINVILPIVFPALYHNSKQHWNRTIHGMVFNALKLFMEINPTLFDEVQHNYKQQRKEDYERSCQRYEEWLTLRDQAIANYKASGSTQPMPAMLREPPPPRPEPFEDDGDGSVDLTANGFDPSESFTLDRSIAEDVVPPSSPTVSATGVPGSVNAAVDVASDAAFEPTSSGPMRRKSVLPIDPSVMRDLEAHRSLEAAQAAAAQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI61</accession>
    <name>K1VI61_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000380">
        <property type="protein sequence ID" value="EKC98826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI61"/>
    <dbReference type="FunCoup" id="K1VI61">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VI61"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="InParanoid" id="K1VI61"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="193" mass="21625" checksum="B31757B3CCB29146" modified="2012-11-28" version="1">MATPQAQQVKQNFLNHPYVVQAQKVVNGQVKQLDAELSKYPVLNDIEAKTKVPKAYGVLGLAASAVFLVFFNLFGLASPISLLIGYALPAYLSLQAIETPSTNDDKQWLTYWVVFGLFSLLESMFLRPILYWIPMYFVFKTLFTIWLFLPATRGAEILYFNVLRPVLGNVKARTTVTSTPVGTTTSSIHEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIB2</accession>
    <name>K1VIB2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIB2"/>
    <dbReference type="FunCoup" id="K1VIB2">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIB2"/>
    <dbReference type="eggNOG" id="KOG2830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041824_2_0_1"/>
    <dbReference type="InParanoid" id="K1VIB2"/>
    <dbReference type="OMA" id="ASKIHRT"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43951" checksum="0C794322FEAC5FBC" modified="2012-11-28" version="1">MSTSTETSTNVPLPQFYASVLRVLTQIFDGDVSVGDEAVQAQLAKATDDLYLISRMITSLGLFSPNESADELSDRDLLFMTVPWVLGEAEQGGGIGGPVPRTEALKRSETAYGAFKQLLNSYGIETAEEGAGAVPADPGRRREAKIAAYKREKETREKITVSLSYINPPVWKLTHQSVLPSHPPSSSNPTVFILALLTEEDSGSVSVNAEEKDVRSATLALLSLLSALTTGAQANTAMELELLRHAPPEPEQGPLEDPRAKRQEDEDAAWRLDRAPPSAAKPKDLISGGGRVLRPFTIMPSMGNLSERERLNSEVFRASHRLPTMTIDEYLAEEQRRGNIITGGGQASYDKPTESELMELEGEMDNYKAEEAQEKKRQKDEKWAQYTDDNRKGAGNTMNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIV5</accession>
    <name>K1VIV5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin (Allergen cop c 2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000335">
        <property type="protein sequence ID" value="EKD00676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIV5"/>
    <dbReference type="FunCoup" id="K1VIV5">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIV5"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1428931_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIV5"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="190" mass="20321" checksum="DF383E77C2039F12" modified="2012-11-28" version="1">MVKVIANKAEFDELISSSKPTVVDFWATWCGPCKIIGPHFAKLEDKYPGVQFAKVDIEEVGSWGSTAMLVRTGALLREARSPIETSSPASIAADVLIRSVKLKLQATSSICSSSLWPESAGCLAFTAQREQALSLFRAGGDVAQEQGIKAMPTFKAYKDGQVIDEFTGAVPAKLTVNQANAQALLDKISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJF7</accession>
    <name>K1VJF7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear mRNA splicing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJF7"/>
    <dbReference type="FunCoup" id="K1VJF7">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJF7"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_940690_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJF7"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="32138" checksum="569B4591F775A96C" modified="2012-11-28" version="1">MVRLVQGDRREGAGTAAACPEGADEQNHIGAGVRYNAQKRKTGNYYSTPIFAFLCKCHLCSAPFEIATDPQNAAYVINFGLTRKAEEWDSAESGGWGVFDTDDLNKDRGGLDEQAGLKATVDGDAFAALEKGETQRDATLSRQARLDELEGASERIAGDPYEVNARLRKRLRAEKAEMLRGQKADDATREKFGLNDDVHLGPAREGDGELYKEVVKAQGPGWSRETAGKEALAQRVRNNTARKMDAFETHTPRIRLRRAKTPPPKSSPPKDPPAANKSTGLGGLAAYGSDSESNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJX4</accession>
    <name>K1VJX4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJX4"/>
    <dbReference type="HOGENOM" id="CLU_1027399_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJX4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="271" mass="29437" checksum="97914043110502B6" modified="2012-11-28" version="1">MWYNCTFPQNNSLNTNCCPSGNASSAGKNSLCLLGLGGATAFTDCLYQTGNVTAPKCYLQEWSNTKPDESAAYPQVAKGVSWFSMAFLGFLLLNGATALQPPAENPVCTKFEPDDRSTWNLDAVTPQLSISTAVMCGSPGHCKVRTGDPQRYYFEVQWAADGPNGPVPVTGDYKSLDLPKDRKFAEKVWPPAVPDEFPFAPQHSGFMAVRMNAAIIPGTFKDCQNGTEYRGNVTVPEASGLYYYATIRSPQDPHGPSPDTESPPTWQDSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK40</accession>
    <name>K1VK40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_04609</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK40"/>
    <dbReference type="STRING" id="1220162.K1VK40"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014629_4_0_1"/>
    <dbReference type="InParanoid" id="K1VK40"/>
    <dbReference type="OMA" id="ICTRFSA"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="17">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="148"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="18">
        <location>
            <begin position="289"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="489"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD01111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="660" mass="72046" checksum="6CAD82181964B54E" modified="2012-11-28" version="1">MSIPDWVTALLPAKLEGPSLLSAERSNSSVDPAALAKLLHGEDQLALRARVEAILRQEGFDAQLAALPSQSRVEKMESSLRRGKHLKALRKQHNWDDASYTAAIGASGEMNVYGLHDKAFIKCLTDQTTDEQKKLFLEPAKADKIIGCYAQTELSHGSNVRGLETTATWDEKTGDFIIHSPQLTSAKWWIGTLGRTANYALVMAQLIVKGKNLGPHTFVVPVRSLETHEPLEGVYVGDIGPKFGYNSMDNGFVLFNHVRIPYVNMLARFQYVDPKTGEYKRRGSPAFVYGGMTYLRVGIAADAATTLARACAIAIRYAAIRKQFADEDKPKDGETAVLNYSLVQQRLLPLIATSYALYFACQELKDLYANYDKLLSAGKTQQAEALLAELHVQSCALKSHGTTISVEGIETCRRACGGHGYAQYSGIGHLYADMLPSVTYEGDNYMLTKQVSRSILKAAKLGVPLFQEAKNAKGGISNDDLVAAFARRVAFLTTQQQQLAKDGWSKNALLVPGWRLSTAYAQYVIVSAFARALPKLAAQLPAPTAQALGDLFRLHALVTLDGSASEFADAGALPAQLGSGIQRQKAIADALARVRPNAVNLVDGWAFSDLVLNSSLGREDGRVYEDIFRRAATNPVNELVFDPRPESKVIVKRREGAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK59</accession>
    <name>K1VK59_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_06107</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK59"/>
    <dbReference type="FunCoup" id="K1VK59">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VK59"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="InParanoid" id="K1VK59"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="32932" checksum="7D8F28537228A6DB" modified="2012-11-28" version="1">MSFPAGVKPFAERQFPQTICMFDVDGTLSPARLSASPEMLETLKKLREKCAIAFVGGSDLKKIAEQLCPDGGNALSSRAVHVTPDISMVVLRQQAGYQRDAQRAAQTLLDLFDYGFAENGLTAYKLGQELPPASFIGHVGEEPYKKLVNYILRYLSEVDCPVKRGTFVEFRKGMINVSPVGRNASTQERNDFEAFDKQTGTRAKMVEALQKEFADLNLTYSIGGQISFDVFPKGWDKTYALGRIADDGYDQIHFFGDKTYKGGNDYEIYTDDRTIGHAVTCPGDTIRDLNELFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKF4</accession>
    <name>K1VKF4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKF4"/>
    <dbReference type="HOGENOM" id="CLU_866503_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKF4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="321" mass="33984" checksum="5FCBCC1CC501BDE3" modified="2012-11-28" version="1">MLIRLTISSAMGMLSEIADETARKMANTSKRYLYSAYFKMKKPCQDECQPWYDFLRKDGKYYGPSVGDGEEEPDGTYAINVTQHCSHLDLAMPCQVCNGNKTFGPAYSDEIHSTTQSQEAGLPNDGMLYLITRCRQSGYATPESLDGYPNIWPDKEEQRRVDVGSKCRPEIIGCFDGANCSDIIDKVTGKPYDNDRRPGDGSENVPTNASAIVYGSTFSAPPSRNTSTSASNTTTSATNSSASSSNTSASTSTPTSNAGSSTSNSTPTLPVLPTSANTTAADSTAASNTAPPQPKETDSGALAVSLPLTLVLGALGIASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKN5</accession>
    <name>K1VKN5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein-vacuolar targeting-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKN5"/>
    <dbReference type="FunCoup" id="K1VKN5">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKN5"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_2_2_1"/>
    <dbReference type="InParanoid" id="K1VKN5"/>
    <dbReference type="OMA" id="LWNVIGT"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="209"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="389"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="669"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="792" mass="86245" checksum="53BBC237D5CDB9E4" modified="2012-11-28" version="1">MGRPEETDLPAPSTAPTSRRPTWRTVARIAALAYVAGNLAPLAWEYAEGLFAPSTATGGKPISLADAEEIYLKVPSNESLYKLSHKYTAHAHPAGSGWDFVTALQVKNDWERALGLPETGPTEKIYEAGSAASQHALRKGSELDVWIDTYYPVMNTPVSSSVALLTEPVYRPSLREAVLEKDPYSVLADEVRSFHGLSVDGHVSAEYIYAGYGRKVDFDLLQAKGLDFKGKVVLVKYGGVFRGLKVKAAQEAGAAAVIIFTDPGDDGDIQETKGYKAYPDGPARVPSSVQRGSVQFYPGDPTTPGVPAYKNATREAGGNFPSIPSLPMSYEDVIPILQALNGKGLQPSDLDASFDGGLRHRGVEYYTGPSDVHLHVVNRVNTRVMPVWNVMARIPGSSPETIVMGNHRDAWVLGASDPNAGSASQTELARGLGVLLKKGWKPQRTVMLASWDAEEYGLIGSTEFAEDFEDWIQARVAAYLNLDSSVSGQHFHAGASPSLAHLVKGAAERVQRGNSSVWDTRLPDTESELSALGRGNADLTATSVSALGQTQPRTEAEGGTGVRPLGSGSDYTAFLQRCGVASTDFGYGSSLQSPVYHYHSVYDNLHWMKMYGDPSFQKHKEAAQILGLLVLRLSEQTILPLNTTQYCHDLHGYYAQVEKLRDDSGLKVRLNNLKGAITRLSEASENLDRTRADLEKLLKKGRKDEKVMKQVALVNAKLRKFESGFLHKNGIPDREWYKHLVVAPGKWLGYGATTFPALTEAIIFDKDKNKGQFQADVLAGLLDGLAIELERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKQ4</accession>
    <name>K1VKQ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKQ4"/>
    <dbReference type="STRING" id="1220162.K1VKQ4"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_5_1"/>
    <dbReference type="InParanoid" id="K1VKQ4"/>
    <dbReference type="OMA" id="CTIGCIV"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="653" mass="71025" checksum="83B2ABB56CA06EF3" modified="2012-11-28" version="1">MGADNERDYDGREKRPSIDSSDSDHGLPLQPVISHHAHFDIPPAEAKDRVDNRDRLPVIDIEHAPVDDDPREWSNRKKTVVLYLMSFAVLAPMISPSIYNPVIDDVKTDLHASDAQIGLSLSLFILFQGGVPVIWASIGEIIGRKPVYIASFILYTAATAIGSRSPNMPVLIGMRIVVACGSSAVLSAGAGSLADMYEVKERGRKMGLFYAMPMLGPSLGSLIGGALGNAWGWRSTQYFLAVWGFCMVIAFLFFPDTWRKERSRIYQKAITDALKRELKHQAQLEKKRQRKLSRGLTSDAPTPATTAPHSRMTSGVVTPAFTEATTDVEAATGKVEGAPSWWRRRTPAWLHRKDKEGAEYRPTLRDVNPLPVMISIWRVPSNTVVLICSGFLFAAQYTIVYTCSVTLSAAPYSYNPLHIGLVILAFGIGNMTGSLVGGRISDRVLKRLTARNGGKSTPEMRLKASFSGMPLMIASFLVYAWTMDFKTHIAGPVVALFFGGFSILFVYSNTLAYLVDANPGKSSSAVGNNSMVRGICACVMSQIALPILHAIGDGGLYTLFAGLLTCSCCGLILVSFKGAKWREKHLAKREGESQATSAPPEENEEGPESPPSTPPAEQRPETEKLEPVNEKSERTVPAPAPTPATPGTSVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKT3</accession>
    <name>K1VKT3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKT3"/>
    <dbReference type="STRING" id="1220162.K1VKT3"/>
    <dbReference type="eggNOG" id="ENOG502QTDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384585_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKT3"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="349"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="706" mass="75321" checksum="F4D0C18E907FE766" modified="2012-11-28" version="1">MYHHPGTTGSSSSTTDPRLAASAAAGGAPSATSQPPVDPPPYSTSSSSSTDPRSSSSYPAHLVSMPPPLAFSGAPAAPGHGSGGPPPPSLTQLSSSTTGSAGATPSGAASWYSGGGGGSSDIRLPSLTAQVAPLDNASTTPSMAQQSQVITIYEFTPQSGVEGTAISINCNLTFPSDHGRGDSGGNKIRLYFGNQIVDTTLRPPTNNSEAYLIIANVPPLHNCGMTGSNAWSVPVTLHAVNDRGILEIQSLGEFGYISEANAFKKARKLSSKAGSPERRLSSAGYRRRRREDEGGYNPPTIPAGTAGAFVYDSPPPPQSQSLGLVRTTQITQVNSPNPGQPNPFIMRSKAQLQIEGDLMTMKSNWSPEMWASRRCLVAFTRRQVGATVYASFKAVEERDWTPNMIVISCLYHEARQECFFTSVDVIYLLECLMATRYTTEEKNRIRRNLESFKPTTLQKNEGQWQEFYAHIMNYPNPKPRNIDKGLKVFPWIHLEPALKKIFSNYSAYTNMPFTFDSPGPNHGSGPMGYPQHAHVSPDPLGFSDERASAPYGAPHGADAMSPYVSHLPSYHRPALSGGSASGVPAGSSSSGEASAPPTAYGGEPPMPGYVNMPPPPGPYGRDYVSYAPPSSLSMTPHPGGYYDPPPPHMQYPHVGRGSSSSDFRVVGYHNEAGNPSRPHSNPSPHMPHNAYPPQQQQPPPPPPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKZ2</accession>
    <name>K1VKZ2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKZ2"/>
    <dbReference type="FunCoup" id="K1VKZ2">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKZ2"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKZ2"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000774">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="626"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="915" mass="101113" checksum="0355C386A76FFF0C" modified="2012-11-28" version="1">MQAPASYVAGLGRGASGFTTRSDIGPAREGPSAETIQEAMAKRGEEIPDPDQFQDPEDERNLFAGTVYEADDEEADRIWDAVDARMDERRKAYREAAEAEAAAKERANNPKIQTQFADLKRGLSVLKDEDWEAIPEAGNMTGKRRKHNPRLEENQNGKLYAVSDSVLAGAAASTQLMGEIDDGPADADGTMTDFVAMGTARDRVLSLKLDQASGDAANGSSTSVDPRGYMTALNSQVLQTDAQIGDIKQARQLLQNLIQSNPKHAPGWIAAASLEVHAKKMVAARKIIAEGCEKCPRSEDVWFHAAELNTPENAKRILARAVENVPQSVKIWLKAASLEADPNAKRRVLRKALEFIPNSVRLWKEVVNLEDDPEDARILLTRAVEVIPTSVELWLTLARLETPDKAKQVLNSARQKIPTSHEIWIAAGRLAEQSPSAVSKDASAEEDAAARKKLAAQVDRLIKLAVGSLTKHQAVLTREQWLQEAEACERDGSPLTAQAIVKATIHLDIEEEDRRTVWLEDAERAALGGFYEVARAVFVVLIESFPDSPSVWRKAAEFEKAHGTPEAVQDILAQGAEHCPHAEVLWLMAAKEKWVGGDVVGAQQILSRAFEQNEDSESIFLAAAKIAAETNEVEAAQQILQKARGQADTERVWMKSAVLERQLGKLDEALKTLDEAIGRFPSFDKLHMIRGQVLEEKGDVAGARKAYAQGCRACPKSVPLWILSARLEEKAGVVIKARSLLEKARLHNPKNDVLWTEAVKIEERAGSTQQAKALLSRAMQECPSSPLLWAMAIFMENPQQRKGRSVDALKKAGEHPAVIMAVARLFWAERKIEKTRQWMQNAITADPDWGDAYGWWLKFEKQHGEPQRIEEVRKKADAAQPHHGPVWQATAKDMKNIGKSTREILEQVADKIEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLK7</accession>
    <name>K1VLK7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLK7"/>
    <dbReference type="HOGENOM" id="CLU_700549_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLK7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="394" mass="43556" checksum="107C3583A68B7026" modified="2012-11-28" version="1">MHAALATRRLGFTSRSSDEELQKRIWAYAESPGQFPIDDAPTTPFPHRRSIPHGPSVPFPDRRSVPFERQSLLDPASNHSSSGQYERESEQDEQSPEPASSPVFSLTAPNTTPPSHAAVPTAHTQVHLLDFASDASVDKLRRGRVLPLHLSPAARHILLIRTERTFDLFPECGVLLTLDPPEPSRPETELVIAIESVQDWEEADEALQAEFPALFHPDCAERYEAGGVYGGIVEEGVQGTDMRASPARATFAAGLTAQAKRRSVQLVTHEDDDVYLLPTPGPGFVNWLLAGLADALELHPGLHVSFANVQSWDSRWVRPHWAGAIVEDLLGMSAEEAAGGGPMRIHLHSGIKQAGRSQHAWDKEKMRRVREDRVGYLDEEGWERVKREMGAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLN0</accession>
    <name>K1VLN0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLN0"/>
    <dbReference type="HOGENOM" id="CLU_601572_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLN0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="156"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="441" mass="48420" checksum="8C2495EB51A1F119" modified="2012-11-28" version="1">MPSTGCGPRTPTDTGLEGAKGLPPRPSPYVRQNSTPSTAQSQPPTSNRRTWDHLRVTRPPPNNRRTSDPLATSSTFAQPLVPRPSLSVTSTQVPTKLPPPSPNYVPRQKPPPVQPVKMATMVDGFSQTEEKSSVDRGNQCSKSNTMSASVHADLIAATNVLRGTKFTVMAGTFNVPDLQLVSTYLRVVGSEDGPDPRTDYVLVPTVAQTNPDRSAAVIELLAQENSKWYRYPAVTYEWILEGVRLGSLQNTNSGDPDRHRIEAILEELVALEELHLSTRDELMNDEAERRLLVCQSMMVRLFRIMLPNTPMWRAMGAGVAPDVGVMTNEELVQSVELASHWKDPAPPACVPPEREEWTDNALDIFLGQESEESWDTDTNAVDNNIAGSSSNHREVSGMQIDSDGSEFRTVRFQTPTPSPFPLSNGQGSAQKPIVIDDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLX4</accession>
    <name>K1VLX4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLX4"/>
    <dbReference type="FunCoup" id="K1VLX4">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLX4"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078034_0_1_1"/>
    <dbReference type="InParanoid" id="K1VLX4"/>
    <dbReference type="OMA" id="QAYAVND"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="26002" checksum="E65523AB64C566B3" modified="2012-11-28" version="1">MSTWDNAIRHTRALESALDTKLSNYSRIGADIAGGGGVSGVEAAEEGVGGYRLVEEEVEELLDKTCRANDQLDQALSDLSSHCNGPTPPSTSMQNALSRHRSNLDDYRRDYTRIKRNIESALAKSDLLGSVRRDIDSYKAARASQTEALLADRDHIDASHRMIDEITATAQATRQAFFEDSATIRNINARMGRVANQIPGINKLIAAIGTRRRRDQYIIAGVAAACILFLLWYMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM49</accession>
    <name>K1VM49_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM49"/>
    <dbReference type="STRING" id="1220162.K1VM49"/>
    <dbReference type="eggNOG" id="KOG1259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456488_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM49"/>
    <dbReference type="OMA" id="HEIWCAS"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="598" mass="64931" checksum="60683EB1CB964167" modified="2012-11-28" version="1">MGGLSSLGLGPAPEPQPVTGQQYLLKLHKYLSINIARLAPPIKRDGTWLQQGYTLLTLGLDPNSAPLSRSVKVPLTLGFGTPTAPRTRPVLLRLPPDKLLYLLLRWQSLPQNLPHVGRTDVPVPPGVPVAARGARADSRSRRGEGDVESVRSWVGSVRSVSMSVVDGGWFRKPKEIDENKILLDLYAICNTLPGLLLHPPFSTDPPVAELMDAGGYTQLGGIDVRVPLDVFRNLQTVLSPINPVLHSLTVHDVEDGDEWIVELLVANDGEEAMGRAPKGDSADESDEASKTNGKGTDAAEASSQTNGADDDHTNSKARFPNLRHLSLHHVSMLSFPRLPLQNLSHLDLSHNLLNDLPDLSHLSSLISLDLSHNVISSVRSAQTFLGNIATLNLSHNRIDCLVGLDRVPGLRRIDLRHNDISDPGEVGRLAVLPQVSEIWVAGNPLSGEFRAEISAAFAAEGKEVLLDNTPLTWSEKNQMEEILRQRGRTVHRQNLREDLVVPAAAPPPKVLSPRPRRPSLPIDQERSKSPGSPTRAKPKSKSPAQDRPSTISPTPDAKGAKDSPAPPETTSTDAETTKTRRTVGGKKKKAKRRVVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNF3</accession>
    <name>K1VNF3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNF3"/>
    <dbReference type="STRING" id="1220162.K1VNF3"/>
    <dbReference type="eggNOG" id="ENOG502S5TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525985_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNF3"/>
    <dbReference type="OMA" id="TMERMSN"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="518" mass="55154" checksum="7DB6D12ADADCDB9A" modified="2012-11-28" version="1">MPIDLSAMLDQLEEWIESQVPPNLHDLPGKMLETVERVGNELIDTLNMHGPPSISIPFPPFGKEEPVVLTPPPPEPSALSKACDRAGAVARRHPYMVGGGVAIAVTAGIGYVGLATGCGPFANVGQEWRMRRKFGDRGVVENGMLKEAIVILAPSPTPPILVPLTASLLKAGYVVIVAVPLVKEAEALERRLSGLQEKGALRVLIYDTDDSTTFPPFHRSLLATLTLRFPAPATKNKGPQTTGDPYSSKQALVPRIHAFISLYPLNPAPPSQPSALPALPTLMSPDANGHTPRFITVYPSSSRLANPDSFGSQVLAHNHKLLATNLTAASGARAISVYVGNITLPSLPAIITEGRALSRREQARQRLHESMTSATAAVSVFRDLFFGTFSGISRSVLYTLGLGASSRDWSMFESRFLRALKSSYGDTYYLGQRSWLPQTLALLPSSALPRVMNVVQLPSETGPAPAPPPKTAHIPTSGSASSSDHEGEDLVSSIHTAGTTQSSASSGLEGSWVGLDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPC9</accession>
    <name>K1VPC9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPC9"/>
    <dbReference type="HOGENOM" id="CLU_042189_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPC9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852313" evidence="2">
        <location>
            <begin position="19"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="504" mass="54852" checksum="0C139954D77A57E9" modified="2012-11-28" version="1">MFGAGVLASALLASVATAQMNQLRTAWTTNPGSATLDFGPSTFPVDPSQGWNFTTLEQSDGVSLWIPPLFDREPRAYTTLRGANVTAHFYGHGAAVRGRVFEDNSTISLTLDGDRRFTNSTVLQGSADYRKLIEIYDDDPVNRWRTLTITLQSGGMQLRNVSFLQTVTMGYQYTQDAPYMGVNATQFDTDEIDKFYTTTGNWKTEKLLEPNYAAMEAPHVVGDPGATIAFRTWPGASTLIMRGIHGREAGEIKYKIEPLPHAGFPAEVTANLGRPIEAVNYFAEVVLDPTVRYNVTITNSDPKRKFKYGAALFYLSSDTYKTWTPEEEYPKNETTETTEPTTERKSWLEVNANAIAVKEDGGTNVGAIVGGVFVVDDTAMASAMHVTPMPLPAAAINSGQTYTPHHPFHPPQEADAGPVNSMDTVPPSYNPAWAGPSTSSDPDGATPSNTVSRSSFMSSTPTQGALHLHSGYDLKNLRAMDEPAEEEPRPEAPPLPTKTKPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQA7</accession>
    <name>K1VQA7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQA7"/>
    <dbReference type="STRING" id="1220162.K1VQA7"/>
    <dbReference type="eggNOG" id="ENOG502S5A2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1273057_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQA7"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="255" mass="28007" checksum="3B3DB5ABC986CA2C" modified="2012-11-28" version="1">MSVPRIAVRRFTTSARRLNAQQGSQGQVYTPKAESMPAPPASGQAYTAPASTPKQTQQVGTAGNVPVEKPVGGLRAGTAELLELLELLELRKLRNLHDDMAGKFPYSPGVKLTDSIVGFVSRLTTPLQYRQPPFPSFITHAIPANPQLLGFSAATGLGIYYLQQDTKEAQGLLTSSVEELTRDTQRITTHLDRLQTTEKDLVALKKEAATKDDLVKLRAELKKACDSLHLENLDLRAHVWGIEQDLQKVAKEGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQP7</accession>
    <name>K1VQP7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQP7"/>
    <dbReference type="HOGENOM" id="CLU_1078437_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQP7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852353" evidence="1">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="258" mass="29022" checksum="CE51EB7B29A4CBE7" modified="2012-11-28" version="1">MVSLAVVALLAVSAVNANPVRDSFSAKLVRRAEEEVMKTKEDYYKLLPAECKEKCDGSAFTVDAFWGDAKCMEDFDGDACHKVVCDTLQQTADCLQCTTISELKKAGKTLSDADLKEYDAYSKETVKIEQEQCKKLGKREILGQFHSRSLVERATDKEIEDWQNELKAQVDAKCIDKCKTTVFSGRPWIDACHIGDMKECNKFTCARFDQMMDCSFCISEPDFKAAGIEGAALDEYRKKYEEEAKKECQAENVELNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQQ5</accession>
    <name>K1VQQ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQQ5"/>
    <dbReference type="HOGENOM" id="CLU_814289_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQQ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="341" mass="37376" checksum="061324C0F653C08D" modified="2012-11-28" version="1">MKGRNKAKTGGNLKSKGVNKGEGKENKTTKRRYTSDDDKNTSQSGAAKRSRAADPESDRDMEMEGSNETKTADREEPEKREKNSNTAASVSSLHRRTAVVFNGAYGKAWHSPIALFKLKLRLTIFRVGRAKGNGNDANRYSVRVLKQILYEAGQQTIDRWIKSTVLPVDHFAEQEPDDSDDEFEMMDEPLGAESMEAEAAPGVAPGREASPVTPSRHHDAAHIANDYSRDRISTSTAANDGDGLGDDDSDDEASDDKAAKLHNTGPPPLSDEDTERLFIQSAQKTHDGSPNPSLDPRGHARPGKGDEHRHPARRRMPRWVEASRPAGSQRSRSGSCLTLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRP5</accession>
    <name>K1VRP5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRP5"/>
    <dbReference type="FunCoup" id="K1VRP5">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRP5"/>
    <dbReference type="eggNOG" id="KOG1300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
    <dbReference type="InParanoid" id="K1VRP5"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="723" mass="81280" checksum="FBA8C5AC42659396" modified="2012-11-28" version="1">MPLKALLKERFASAINSIPPGTWKALITDEHSQALLDTAFTNYEILQMNVTGVEPLMSPREKMSVDAIYLLTPTAQNVERIIADFASGRDTYKSAHLYFVDATEDRVFSMQWPQAFFSMFGALGGQVTADFAMEAFHDDMTVASRTNPYIRYYQPTHHPPLGPLAQGGSTGLHQQQKQAEQQQQGSSLRWRAAMGSSRAQEAQGDSLSKVLAQRIQHDLDHYIEQNPDFPAHSDRGRGTLFVVDRSVDPCAPFLHEFWYQAMVNDLLPIKDGKEGRTYKYTFTNTVGGKEVREAVLNEDDEVWCSVRHLHMKDAIDKLMTDFGKFVSEHTAFSGNAHNVQINDLKDMLADLPQFQTQRDQFSLHLDMAQECMGIFEQHKLNLAANVEQCCATGFTPQGKAPKTIVEEMVPLLDEPKMSSLDKVRIIALYILFRDGVADEDRRRLYQHARLNINEQDMINNLVHLGVRVIKGANAYRGQRIKNKYSNKDEEYDLSRYKPAIGLMLEEANSNRLDQHLFPFVRETPPELSQSLRASHDRPPAPSPSTSLRSARPTWHKAASARNAANEHRQRYIIFVAGGVTYSEIRQAYILGEALGKDIYIGSTHIITPESFLKDLRSLGRSGVGGNPPNAAKMYPGAPGRSDRRQPGEPQAYQAILDERHWVPFVGPPALPPPVPQQQHGGHLQQPRLPHSASSHTNLSVSSKDSKDGKVKEKKKGFFKKRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRQ3</accession>
    <name>K1VRQ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRQ3"/>
    <dbReference type="HOGENOM" id="CLU_1157088_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRQ3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="25826" checksum="1AA58CBDB3E9B682" modified="2012-11-28" version="1">MIRETGDRYHKSARGLCTKPPAGSEDSTALRLRMVGQALVRSAFHRFSGSSALANRHGSTLAGLSPRSTALRRPNRSARHEDDSELRKTMSGAVSATPQRSGTNSSGTAGIVSNSAGSAVCRAALGWYVPPETALPPFNPISSTDGFGWPSFWNREVMNAAAVVYSESDSRQSPVYGCDGYAGSARIVSSAARPSVRLLESRLPARQAVLDQRRRNTRLTQRAKAVQAERSLLPDFPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS52</accession>
    <name>K1VS52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS52"/>
    <dbReference type="STRING" id="1220162.K1VS52"/>
    <dbReference type="eggNOG" id="ENOG502RX83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076356_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS52"/>
    <dbReference type="OMA" id="DMPGYGC"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="385" mass="41883" checksum="E3B3B6F6D8BA9C9C" modified="2012-11-28" version="1">MNDVPPPPRPPKNMRLRNLVPFIAGASAATSAPVDKLGDSTLAEPTPPFDPPTAPLSPAPKLSPSNPPGYQDQKAWKVIQSHLPLSYQLNASTLPSEEWWDWSGHKIHLDRYPNPSAPVKVILFHGVGTNGRQMSTILGHPLSAHAETVATDMPLYGVTRVAPGHIVSYDDWVAAGAAFVDYELARDTRPIVLYGLSAGGMLAYHVAAANPKVKGIVGMTFLDQRIREVRDGTALLPAVAQLGYPIAGAASSAGLAGLRIPMAAVSKMWALVNDKPTLKDFFRDTTSAGNSVPLKFLASYARYAPKIEPEDFTVCPILLTQPEKDRWTPLEYSELFLDKIDKVRVEKKTLPEAGHYPIEEEGLRALNRYVQEFVLQVAKEAGTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSG5</accession>
    <name>K1VSG5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSG5"/>
    <dbReference type="HOGENOM" id="CLU_957089_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSG5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="31258" checksum="C2F83AA8A5C2DE78" modified="2012-11-28" version="1">MDTDKAGAIPNGHCGVNEPNHQNTCFSTPRSTILHDHKRSQSASATDPDPLSQLSTTEPTTPKSKSLPPLLPPAELYSHLRDTTTEVAPHPATLSPLLRSSSFRRRFSTPPHLSPVRSPCRSRPPSPLATKTHSGSSSSGYFDFMPMSGTDTPMLDRDRECQAQGRRGSIGSDALLLTPAEERQFNLSGWNTNSTASTPRTLSQRGSEDQLHKSAAASPEPGSKLSGGDSPSTGTLERRARRRQVVRLDSFGGEGLMRKPSTRHLDGGFPGSEMSQMPGGTKAPPPTPMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSY6</accession>
    <name>K1VSY6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSY6"/>
    <dbReference type="STRING" id="1220162.K1VSY6"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333750_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSY6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="525"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="820" mass="91498" checksum="E4D388D696BBF988" modified="2012-11-28" version="1">MDKVADVIEQANRQKRPVKQPTFSNLTLPSDYDHLNLVTRLWLQSRIIKPKEWEEKEKEREKRREEREKERQRRKEKQALEDGSTEPVTTKDEKDSKEVDRADGDSTPASEASSSSASSSSTSATSVDDLADEKLGLTVSRSTDGPLFRAAGSPRPKTLAEVWLWLDLCRELSPFLTKGVRKLHPMRLFIYLLEQMSDRLHTTVNLYATSQLYDLCERALGGKPASWSTALRVASSGMAMILYRELTGRLFNDNSTKLHFERQYLSMRLEAPPHGTDELSSALVYEAGIFSGMESAPYYHSGPFGLVNGVSGALAELVDIAAQVTMLVQAIGGLEQIKKRDPKSLTLIGLAFAPTLITKLSDFVYSFDEDDDEYEQHEEDVTEFENVEYLMREIATSTKYKQEATLFGLHDWCLKTWDKAREMLQAQSWEQSFQSQAKSVGFKLLNEMAGTAFYTIDTGLSLGSIHTYQGTARQLVYSVRRLFNHLNLSYQSVFYAAAFAGASEPSPRGLDIDFETTRQNGGMRIEAKDLSFTYPGADKPTLTNVNLTIEPGQTLAIVGYNGGGKTTLVKLLTGLFEHSSGSLTINGVAPRDFNSKTLHKRMSALFQDFNRYNLTLRENVGMGLVEKIEDRAAVNQAIEDGGAQAIRAKGGLEATLNPWGEPEPPRMDMKTWRDVDSDDDSDDDGSWVQLSGGQWQRVGLARAFMRAKESDLVVFDEPSSALDPRAEAELFNNIHNLTNIAGTTTVYISHRFNTVRKADRIALMENGTIAEYGTHKELMEKKGQYYELFTMQAEGYLDKSETATPAEAAVEGANTPAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT37</accession>
    <name>K1VT37_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT37"/>
    <dbReference type="STRING" id="1220162.K1VT37"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_1_1"/>
    <dbReference type="InParanoid" id="K1VT37"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="184"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="454" mass="51352" checksum="74126B51B61866A4" modified="2012-11-28" version="1">MLRNLRPLLAKAPVARQRVAPFAVRSFASEVQQPRKSTPATHTTSVEDLHNLSPEEVLKEHEGKEGNMRHFTVNFGPQHPAAHGVLRLILELNGEEILRADPHVGLLHRGTEKLIEYKNYTQALPYFDRLDYVSMMTNELSYTLAVEKLLNIEVPERAKWIRTLMGEITRILNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARMHAAYVRPGGVAFDLPHGLLDDIFKWSTQFGSRVDEIEEVITGNRIWKERTIGIGKVTAQEALDYSFTGVMLRGSGIPWDIRKVAPYDAYDKVEFNVPVGKNGDCYDRYLCRVQEFRESLNIINQCLNKMPAGAYKTDDNKIVPPPRASMKESMEALIHHFKLFSEGYSVPPGETYTAIEAPKGEMGVYLVSDGSNRPYKCKIRAPGFAHLAGADFMMRHAYLPDAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTC9</accession>
    <name>K1VTC9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTC9"/>
    <dbReference type="HOGENOM" id="CLU_506405_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTC9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="538" mass="58531" checksum="16C88556D09C27CA" modified="2012-11-28" version="1">MSFKRRKALPTSIAIQSGCKKLQDVALKTRTERLRFSKLRNSIPTTGTETWMDEDPEVTVEEQETSRDPEKIGGLMEEFMSCYAENGKSADPAFERIAGTALNRLSFNLQAALEMFLPEDALRDERDSLKNSVSAFGLARPVSSKGVLGPDSVKIILEHVLKKNGEESTGGQKETALLINVDMYSGRRVAVSHPARYMIRTCYVGSCDDFGTQTLRKWWILKASGPSATTRGFRREGSGQSTAPYQGGVQPGEYDLRVELVLPRASPEYWCSHGPGGGDAAVVARPASLQRQSRRCYRGPQAARASVRQTRPSGSEPRSVWPLYLKGAAEQAEGPAVKGTGMIHGKSKEKLSLYSAATEMLAGHSQRSHTLMTNYIRVDNRISLTAGTTDEGPPVVPQTAAANQLVAPVGLLSKKELRVRDPELGIYEEMARLLRSSLAAGSEYWKLTAGFRNLPGIGAMTAVDGAGLLSRLQKIIRNKVQKLRRQEEGQPGRVELAAAAHNSLEIDKLISDLDAISADDGKTTDGVAGLSEEATEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTX2</accession>
    <name>K1VTX2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA strand annealing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTX2"/>
    <dbReference type="STRING" id="1220162.K1VTX2"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1176133_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTX2"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="236" mass="25077" checksum="364B3A2D2D76C826" modified="2012-11-28" version="1">MKGRAAAIEKKEAVTDATKRALKTFGNVLGLCIYDKEFNNQISKIKPGPPVEDLYRRPEFEPQLQPAPPAPARASAVPPHVSGFPKAAPPPAARRVSAGSTVASVNSPPLRPVADETTDFSADEGFSFSQDDSFFSQIDESELMVADVKRETHPSRGRYTGDTAGAAARRAAAIRAAQAQSEPVRLPSPDKPAGGLNDLAAQPAGFGRPTLNLDLENVRPGEFANFASAKGMRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUA3</accession>
    <name>K1VUA3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUA3"/>
    <dbReference type="STRING" id="1220162.K1VUA3"/>
    <dbReference type="eggNOG" id="KOG4042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1116416_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUA3"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="26473" checksum="F24B411B9B9EB6F7" modified="2012-11-28" version="1">MSVASSRAQSLSPRKRPTRASKTHLTQAGCYVSEQCVLEGTIVLERGCVLHPKAVIIVAPTCTVTFGPGCVVEENAVLHFPGPGNATVGQGNAFQVGCAVDLVPDVVPPSSPPLPAADGTVPPPTSSGVVPSIGEWNTFAPRSRVKSVRVGDWCTFGPGTALRPDHPQLEVEDAGSRRWKAVPSQSVVYGATSRIRHWDGSGKEHELGVRRSATEFLREIMPKQQKRDTRPPPPASTPQAQQAPPQAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVG0</accession>
    <name>K1VVG0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVG0"/>
    <dbReference type="eggNOG" id="ENOG502SBIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447725_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVG0"/>
    <dbReference type="OrthoDB" id="2565314at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="65183" checksum="7EA97CA6225EB0C5" modified="2012-11-28" version="1">MPAAVHSATMVPLKPVPTQNRPPSPPPDDTLPRSTSTPFQPTHKRRGGGPLSSDGASRAPLLGMQVIQPAVARRQGGGKPLLEWISRKLGSRRASDAQDREAPPFARRNQPVQSSTFSHSARNEATATRFWRDRSEQPAQDTALEPYPTRVSVDAPSLADSQSMMSFGYRNPPSERRREANNPYPSLPIPLVRRSYPASTIDGDSRAPSMSMLSRSRTSSLRSLSSYARRHPVSIADDDSNASLYPRNADEDASLRPLPPSPTSMSIISRAGSVPLVRSDSVPHKTTPAPVMRRDTRSSSVDGPRSFMSDDAANLRGSREGSLASTKPTTIISFESGAPAHIAVAPSVSSSSPVVRPLSTSTGASGGGLAQSLPSPVSPTFLPANVPPEDFQVPKHTRYHPRNNPHPGSAPGPNASTQTLASSTFGLDTTRSIPRPSSVRIRDSPSAYHAHGRVFAERPGSMQGDAVSTHAIAASVRTRGNTRADDDASMRAVRRRGSWESGESRWSWKPGAPGPGTGAGVDNFSLLRRGNEDLDDVMSTNRSSVHTRDSYRTAITTWDDVEDEPSPLTPDSAGGLAAAQAAQAAQAAQAAQAAEPAFSDAFAPPKAPMSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVR7</accession>
    <name>K1VVR7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVR7"/>
    <dbReference type="FunCoup" id="K1VVR7">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVR7"/>
    <dbReference type="eggNOG" id="KOG3485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138804_4_0_1"/>
    <dbReference type="InParanoid" id="K1VVR7"/>
    <dbReference type="OMA" id="EWALNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="80" mass="9019" checksum="516428DB5A61218B" modified="2012-11-28" version="1">MLRYTANQSLEQLHARYTGTGHADMTKYEWATHQHRDTLASIVGHPPLLAYISIADGECQARERFEVIEPCGPPPPKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVT9</accession>
    <name>K1VVT9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CnHHK4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000330">
        <property type="protein sequence ID" value="EKD00968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVT9"/>
    <dbReference type="STRING" id="1220162.K1VVT9"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014604_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVT9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="351"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="603"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="826"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="573"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="915" mass="101253" checksum="3F5803710EB1FEF8" modified="2012-11-28" version="1">MPPAKDEVARYPHPAFLLPTDWDSNGDVTWGNAAWRAVVEKRTLFELASDGDCERLRVWIDKASAAPLRVEFTFGAYELAQTATDDGFVVISMPCMKGIKRTGMSVPCQRPSPSNSAHVVEYTAPQLTTVPDDNNKLLGSIANDLMIPLGLVSGPLDDLKQEIASDDAVQLLKLARRNVGRLRSLVTTLIEVSSMKHSQESADFVRTNLGAFTREISAVFIKSFEKSSSSLNVNCDLADKPVYIDRQSWEKIIVALLRMATHYNNGGVVDFHIEAAGSLSSETNAPGGVVLDFALISRLVNVHGGKLALRGNKTSCVTISLPLGSAHLPQDRLYQGTEPPAYEVSKWDDSDDGSLSSPMSVRGVDRSTLQFEPTDCVLLVDVFEAKDKDEALRIIERTPPTLVIADTMLPSDGEGLVATMRRGSRTINTIPVILLTGHERSDAGAADDYLLRPFNARELLLRGHMQMQMAKRRVLLENMYDQQADEMRMLMDESPIGIFRGDPGGAITYYNDALYDLSGHPRGTDLQDWPQYIKEEYRKPLLEAWEHCRNSDQMEYTMDAQWIGGRWGSRRSSALATERARVAEEQRRNAENAKAEVDLLVDITSHEIRNPISSLMQCASLVRTNLVGLRSELQKLVGDSFYPTEQLVQTLGDDIEALDNIYACGLAQERISNDVLALGKAQLNLLDIHNIDVNIKDEVQRIVNVFKNEARMGRIRLSLEFSEALDRLQVDHVMLDPVRFGQIKQRRIDVHVDIGTSPPQNGVCTLSDGPVTLDTDLYLCVSVADTGPGLLPSELETLFQRFSQASSKTHTVFGGSGLGLFVCRKITELMGGHIEVASRYTEGSVFRFFVKTRAVNGLEAVERVRAAPFDCILMDLEMPVMDGYTATRTIREDEAQSVSASAIIALSRFSNPALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWF2</accession>
    <name>K1VWF2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWF2"/>
    <dbReference type="STRING" id="1220162.K1VWF2"/>
    <dbReference type="eggNOG" id="KOG2290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1157090_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWF2"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="27409" checksum="15E8B329B7BF612C" modified="2012-11-28" version="1">MMSGRPLVGTQDTYSQSNDRFDSPMDQPPTYDRYSDRFADKQLHDHGPEQNAYDSNNPFVPYSGPGYSDSTEGRRYEEPWSYTDNNHPKTPVARPNPTEYNPLFEQPDAMEMRPLNPSKPAESWPPPPATHSRREQAAEALLFATGIGRLLVLLRMKKDVPVQEAINRKRSNVLPQKWPIMTICLIVIMTCMMIWELIVNKQKTGSVIATKPTFNYMIGPSFEVLINIGARFVPYAPTWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWH6</accession>
    <name>K1VWH6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWH6"/>
    <dbReference type="eggNOG" id="KOG2676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039868_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWH6"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="390"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="521" mass="55940" checksum="770370F1DE26B130" modified="2012-11-28" version="1">MDAKALQGALTPDSLRSTDSANAATKTIDNVARYVAQHLENIIAEINAAGKPVWEALGNLWPAVAESLDPSPKAPSAVSEEARVALAAATAKLERNLIAGLFENQQAALPHEPLIRRTIFDVTTFNRIEDEKLSMQSADALLAKYLTGGREDDVVIFLSVHVQANDRENLLSPTGVKWLAQLLGRLDDWVDCEDARFELAVGIVNRFIVRDLQSRLFSALGAPDQAGLTEPEEEITPSQTTLLKQLDAYLAQRADVAGTEQEEDGDNASPSPNAFLVPLFGRLAKYASASMKSGKDDARLPPVLIGLVLCTECLSSIVLSAQRRADAVKAAQKKGQNVSASAGGDEEIVAELKTDKFIGELVSVLQATDAFLPRVKPTAEENTTLPFQNVKRDLVRLLGLLAYDDTKVGDIVREKGGVETVLGMCETDERNHYLREHALLTVRNLMTGNPGNQAIIGKMAPIGLVGEDGELKPLPQRIKESHEKAASAANVPSSSAPQPASVQEVPETNAAAEQKAPETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWM7</accession>
    <name>K1VWM7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWM7"/>
    <dbReference type="HOGENOM" id="CLU_783440_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWM7"/>
    <dbReference type="OrthoDB" id="10647669at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="354" mass="39722" checksum="57D5E7B7A3F5AFA6" modified="2012-11-28" version="1">MDVTAAHRNPPPGAAQASTATHRRTRPRTRRPTPPHWPRTFPCTTRSALGDYAFFRSSTRSRILRAATLASNAWDDAVAEDRWDKITLHMFRLAVFGKVYELNQGEWDNRFHLPSLDDWMAETTHMMFFAYRLAGYQLHQHRQSIPKLVDVIPFTRACLDYCTTEDLDPDISDYMKTRPSFRFDLGVFDPVNIPEENYGYRCTEIVYTYRRRLGKYIRVKGGEREYACDELGNPLSLVHERVVPSPSKNGRVVHSGQPVAASVLNRSTGSTGTELSENAPGSLSSDHGHSSSGRAASPRLLSPRTSLDARDDKAVTHSPVLVAHESCHGLTGLEDAFLELNKRPPSPVETSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWN5</accession>
    <name>K1VWN5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ER to transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_01895</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWN5"/>
    <dbReference type="FunCoup" id="K1VWN5">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWN5"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="K1VWN5"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD03882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="956" mass="104913" checksum="A576DC38141622EC" modified="2012-11-28" version="1">MNVQQIMLPQGWEARWDAGSGQYVYVNQATGQSQWEVPTNPSFPTGHATSTSPAPAGGAASHHHSKRRQYPVADMEQMYGGAAQQQQPGFQAATPQFNQPQAPMQQQQQGGFQQPGQFFTPGMEGQQGQQQAQPGFQQPGAQQPGYGQSGVDQMSNQFGQMNMNQVGGGYAGHNQPPGWGQQFEAKQLHPINTVNLIGLQPDVRLLDAPPPPALLPSNASVTNSPNIHPDPSYQRCTLSSMPTTQGLLNKSKLPLALVMAPYRSYRESDGDEPVPVVSDSVIARCRRCRVYINPFVTFTEGGNRWKCCMCGLSNEVPQLFDWDSRENKPADRWARKELNNSVVEFVAPTEYMVRPPQPPVYCFVIDVSQPAIQSGMVATAARSILESLDNIPNEDQRTKVAFIAVSTSLHFFPLPAGKDSEASMLVVSDLTDVFLPKPVDLLVNLTESRPAIENLLGKLSDMFQDTHVVGNALGSALQAAHELIGKIGGKIIALSASLPTLGTGALKARDDPKLLGTSKESSLLTAQSNFYKTFAIECSKSQVSVDMWLFSSTYTDVSTLSCLPRYTAGQTYLYPGFNASRSEDAIKFATEFGKSLATPIGLEAVIRVRASRGIRMSAFHGNFFIRSTDLLALPVLPVDQNYCIELQLEDDLKQPFVVLQTAILHTTCYGERRIRVITQALPTTDSIAQLYASADQLAIANYLSNKAIEKVWAGSSLEDARNLITNRLSDMLSVYKNQVAGSAGASAQLAVPANLSLLPLLCCAMIKHVGLREGSTIPPDLRAYAQDLLTTLPVQSFIPYIHSRFYSLHNMPAEAGTIGEQGVIMPPAMNLTSERLERHGLFLIEDGQNIFLWVGQEAVPRLIQDVFDLNSYADLQGGKYTLPQLDNPFNQRVNAIIAKTRELRRGIYRPHLYVVKSDAEPALRSWALSLLIEDRMDNMSSYAQYLTRVKNKINGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWQ3</accession>
    <name>K1VWQ3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWQ3"/>
    <dbReference type="HOGENOM" id="CLU_2814241_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWQ3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852141" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="67" mass="7396" checksum="839B95F8BF0209D8" modified="2012-11-28" version="1">MVFKTFACLVALMVPVLAAPIPVRRTAIEAAMLEIERDVLPLHQISKRRDAVDPENTASAEPSLWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWR9</accession>
    <name>K1VWR9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWR9"/>
    <dbReference type="FunCoup" id="K1VWR9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWR9"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_0_3_1"/>
    <dbReference type="InParanoid" id="K1VWR9"/>
    <dbReference type="OMA" id="CTRDEQR"/>
    <dbReference type="OrthoDB" id="2565108at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="57"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="354" mass="39309" checksum="4EE0365EF90C4336" modified="2012-11-28" version="1">MSNKSAKRNKARRNKEKRDRDELRAANEYEDTASATSTPGAGPSSASGINYLTEEPCLFEVRSVPGKGLGLVATADIPKGTRMLKEAPLLVVKLGKPVQIEAAVSAAIQSFGPWKKKALLGLYNCHRDTKYKLHGIFVTNALPRGEGAGAVFEFISRINHSCRPNSHICWNDNLGMETVHAIRTISSGEEITINYGHTGVSEERQAWLKKRFKFDCACEVCGLGQRQLRASDSTRRRIRDLTDALHRSLSVPHIPVNIDTIRQNYLDVQELIKGEFGPDCAMRAEIYELAYDIAVLEGRQFHAERQAQAAYDIRVVAQGYDHPDAEEILKTMCDPVSDPCFGVCAPKPRNGRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWX3</accession>
    <name>K1VWX3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000320">
        <property type="protein sequence ID" value="EKD01333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWX3"/>
    <dbReference type="STRING" id="1220162.K1VWX3"/>
    <dbReference type="eggNOG" id="ENOG502RBB0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415144_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWX3"/>
    <dbReference type="OrthoDB" id="2575040at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="661" mass="73015" checksum="3F626936EBEA1A1D" modified="2012-11-28" version="1">MEEDHTASFISALANLQPVEYDNIASLDGWSVDQLKQEVIRLRRALANVGGGVQDIMPVFQPQFVQLPPPNQIAQQAHMQHHNHSHNHGHGPPHHHSPQTSHHHALPHHQSHQQVHSPHIAQQNSIPRGASVTPTQPTPPALPHAPLPPYGSPYSHTSRERSASRKRALSPPRKKRDEGTGKRVEKGRRVELARAIRTKMRYAMNIGLDDDLPPPTALTLPSAPPEVGAWVPNWPAGVSDPNNAQWLDRVCALFITEARNYQVWNKVPPEDLDEDIVKVSVAGRASRRAIRFPFGWRTRKSILALARTAFQNFAKRYMAEVDPKHAKKKEKYVKNRRRWARKDLAGTVGADSVLDAGPTRAMTLDEIGGDHSASARLLGSGQTAASYQAAGDQRPRRPILQWHDVIAVIACPVCPSAAILPAVVRSKRPSGYLASKQKRRAKAALDPSFGSVLPQSALHIDYMSSEYSSAGEDEGDEQSASRRGHWLEVLRSHSPEPQKPGKGGWAEGVDQKVLEVRTPTWRSPRLNELYQRLDMISAAQAAMRAQPASHQPTSPGSKPPLRLGHVAPSHKRFTMPSSLMRRGHLPRDLGEGWMWASGVAGVWPERSRSNEFNQPSHNSNTNNNTTTTASANGIRNMVNVPELEEGLDASVDALVQGWTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXW9</accession>
    <name>K1VXW9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXW9"/>
    <dbReference type="HOGENOM" id="CLU_100326_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXW9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26250" checksum="A41AE0F65DDD6559" modified="2012-11-28" version="1">MPPRKKVKTQNSNSTSSRWNNGDFELVSSDGTTFRVPTYQLQAASTVFRDMVETCSGEKRVELDEKDSTVDWFLRLSTGNVSFLESLCMKPNWSGTLELLHFVKKYDCAMATNQLKIYLRLQSTSPWNPHLRVLIAMHLNLTHEIANMIENEPDVFRWLRPSAFSSSETDLPPYDLFCMIPHRYLWALSSPDVLPRTRSSHYIRGSDHDALARRESFLCLLAQTENAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZA7</accession>
    <name>K1VZA7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZA7"/>
    <dbReference type="STRING" id="1220162.K1VZA7"/>
    <dbReference type="eggNOG" id="ENOG502QRGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045411_1_0_1"/>
    <dbReference type="InParanoid" id="K1VZA7"/>
    <dbReference type="OMA" id="LYIHSRT"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40114" checksum="5B3D89BE3737FDD0" modified="2012-11-28" version="1">MTVETQAPVTISYKDLLARPESLKSDIERALGSDEGCLGVILVKDLPEEFPELRANLFQQSARLAALDPSSLAELESPSSSYCFGWSHGKEVMNGRPDTAKGSFYANPLLDSPNVSSDLRAQYPEYYEGNTWPSASVLPDFERDFKALGGLIAQVGIELAKACDVNGFSPTPIAPMIERSRANKARLLHYFPSTSSSSETEAEGAEGAEGAEGAEGAEGKAEGAEDDACGVHLDHSLLTGLCSAQYLSPTPNPTSPPSFDEVSPNPKAGLYIYPRQRLSPEQSEKEIGLALKGKSSVAPVKVSIPKDCLAFQTGEALSVLTQGRLSATPHFVASGRQSSSRETFAFFLQPDVGDDLGGETFGEFTKRILKRHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZN3</accession>
    <name>K1VZN3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZN3"/>
    <dbReference type="HOGENOM" id="CLU_1027398_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZN3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="271" mass="28794" checksum="DD466AB6072D648A" modified="2012-11-28" version="1">MYCKTPLADAQPELRPPLQLDGHRLQLMRSNSPQRMLHLPELEGLEAHAQSVVRPSYEVFDVELNSQPATSDLPCCSSGSYSTDSAAADTAVSSEPSSATASVHLADTPVSICGVSCLNLGEPSPARARLSSADNQRAPTGSVHDPSVRRSCSTEALAELPVVESSTLVSQQQLGIAHQQADSSTCDRADTPSLRAVGRQLVVRDSQLTPSTLPNSSGLRCDSNFACKTAKRARCLGETLPVNAQPMLLGALRIGIRHLCLSVTRHLPVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W026</accession>
    <name>K1W026_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000285">
        <property type="protein sequence ID" value="EKD02428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W026"/>
    <dbReference type="HOGENOM" id="CLU_912728_0_0_1"/>
    <dbReference type="InParanoid" id="K1W026"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="305" mass="33816" checksum="00C605554628EF03" modified="2012-11-28" version="1">MTDDELEDELKEGDEHRHCIFSPSRTSHRIHLHNVATSCSLMAQAAGVRSVDIDQATIVVIPTTATQPPAGARKATIFVSESWLSHSIDAHDLLPFDTYSVSFYKEFEDRKPDIKDLNNSSLRHPIDQTSNVASSHTTAVKRESSSSGQETGAGSNTSHAASRVPTADRAVPSYALEKNDNGQDVVVLLDSDDEGEGAIDDDDDDLGGALKRFKKRKTHAKDVQKARYDVAECQKDRVQEIINALRAWRRVGSASKQDTVKYLRTKVKFEGWVSIFEANRPYIIQNVPGMGDRWGTAASKGYKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1W034</accession>
    <name>K1W034_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W034"/>
    <dbReference type="FunCoup" id="K1W034">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W034"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_18_2_1"/>
    <dbReference type="InParanoid" id="K1W034"/>
    <dbReference type="OMA" id="NHLPFGA"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005825">
        <property type="term" value="C:half bridge of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="205" mass="23443" checksum="C488156FE0B93A8D" modified="2012-11-28" version="1">MSAFPRTAARRSAPVPARPSLTEEQRNEVNEAFDLFDSDKDGFIDYHELKVALRALGFDLKKQEVLRILREHDRGNAMVAKADFEKVSVALRSTIYRQSRPSYRADRRNPAVPDISEKTMQIPEPEAVTEKILARDPLEELRRAFALFDDDKTGRISLRNLRRVAKELGEQIGDEELQAMIDEFDMDGDGEISQEEFIAIMMDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W091</accession>
    <name>K1W091_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W091"/>
    <dbReference type="HOGENOM" id="CLU_2016831_0_0_1"/>
    <dbReference type="InParanoid" id="K1W091"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="124" mass="13873" checksum="75CFD3C35A485041" modified="2012-11-28" version="1">MNPSESRQWTESRQWAERSKWLKRNQKVTPQPLKPVERRPSLASNTSSTSQSDSMDIPGMGQQRRMSESSMASSQGSSMGTSPTTELKNMMSGMKNASSGQQQMNPLQPPRGSRFSNSDMHMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0D3</accession>
    <name>K1W0D3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0D3"/>
    <dbReference type="STRING" id="1220162.K1W0D3"/>
    <dbReference type="HOGENOM" id="CLU_710158_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0D3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="389" mass="43722" checksum="EEA757FC183C9784" modified="2012-11-28" version="1">MQVHDIRSVQTIMGYTHVLDTSILANRVQQLENVLSRLITRVDKVEDYNDLLYEFKDPLPTYRPNKREGDEQDRKDSKRQSTDHKPSLRDHMDLDRENSVSASGHTKAASIAPSNLSQDIISPVMTMPPLRAGGRPPHQPQPGPSNSHNQIPTQQGTPGSQIMGGEATWMNSLNRDPGPYGGAYTPSNMDFLRSGFEPASKAPSAHEHDAALALEGMALGRELHNVIPQSRDEQNNNEPTPGSPITFSSFVQSKKIHKPSGGLKSFPAASRLPSIIVGKYVINHYLENVDFRWRCLHRPTFERQLEDLSQRLRHKSTDFYRDELSTLALYASCLAVGVHFLDDDGYRDLNLNEEQAEQLAATCWEVSYQALEASDWMQVHDIRSVQTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W135</accession>
    <name>K1W135_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome subunit, beta type, 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W135"/>
    <dbReference type="FunCoup" id="K1W135">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W135"/>
    <dbReference type="eggNOG" id="KOG0173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="InParanoid" id="K1W135"/>
    <dbReference type="OMA" id="KQHLFRH"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="6">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="29916" checksum="432C2F69D68736F8" modified="2012-11-28" version="1">MAATSAQPANVGFDFSNYARNEFLGAKLGGQPRATSTGTTIVGLKFGGGDSGEEEGVCLGADTRATGGAIVADKNCEKLISSNLELHSLSQGRPARVVTAMTMLKQYLYRYQGHIGAYLVVGGVDATGPQLFTVHAHGSTDKLPYVTMGSGSLAAMAIFESAYKENMTRKEAIDLVARAIRSGVFNDLGSGSNVDVCVITKSGTETLRNYEKPNERVHKNRDYKFRRGTTAWLKENVRDLIASETVHVTTGAGKAQAGFTDKPVGRGEGPGGEEGMDLDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W629</accession>
    <name>K1W629_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W629"/>
    <dbReference type="FunCoup" id="K1W629">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W629"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="InParanoid" id="K1W629"/>
    <dbReference type="OMA" id="YLWGAAQ"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="43184" checksum="6804EEF466E44F5C" modified="2012-11-28" version="1">MTTADATITTEAKQDPVFLLNGDGPYVVPQKYIFSKAHLEAFTRSKTHDAILGFIDELNDTVVGVKLSEAGEPSEILDDVLEAAKATPPVDNKLSRFGNPAFKTFYDKVTASSEKWHATIPGLKPEAVCEVQAYFTESFGNRERVDYGSGHELNFLCWLLVLTRLGVFKQSDYRFLVLGVFWRYILVMRYLQSTYWLEPAGSHGVWGLDDYQFLPFLWGAGQIKSHKHMRPKAIHDAELLEAFSPEYMYLSCIAFINSIKTHSLRWHSPMLDDISAVKTWDKVNSGMRKMYAAEVLSKLPVMQHALFGSILSFPTPEEDPELAKAIADQGEVQLDAHGHVHEKGWAMDCCGIAVPSAFAEAAAVKGGAAQVQPPPFTARPGIKPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1W693</accession>
    <name>K1W693_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Platelet-activating factor acetylhydrolase IB alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W693"/>
    <dbReference type="STRING" id="1220162.K1W693"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="InParanoid" id="K1W693"/>
    <dbReference type="OMA" id="CIRWAPP"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="408" mass="44394" checksum="AC8E417289F2286E" modified="2012-11-28" version="1">MLSYLLASGMQGTYDALSREAELEDFDAADPKSKFSGLLEKKWTSVIRLQKKIMDLEARNNALVEELASPTRAVAGSSSNTPFIPRPPARHTLSSHRAQVTRVTFHPTWTVLASASDDATVKIWDWESGDLERTVKGHTKAVTDVDYDPKGNIMALGPGKRVQEHEDAARTRPHGIERALHADGRAAHLCEPRQDDPCMGSVDGTLTGHSEWVREVVPSDDGRLLVSVSNDQTARVWDFATGETKSELRGHEHVVECAVFAPANSYAAIRELTGINSNGGAAGTRPEAGRYAATGSRDKTVKLWDTASGQCLRTFVGHDNWVRALIFHPSGKYLLSASDDKTVKVWDLATGRCTKTLDAHGHFVTCAAWGRATVGGGGAEKDGKKDEPRRINVMATGCVDNTIKVWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6G6</accession>
    <name>K1W6G6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6G6"/>
    <dbReference type="STRING" id="1220162.K1W6G6"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577705_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6G6"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="51789" checksum="7840B928D4151AFB" modified="2012-11-28" version="1">MLLRHEETPNRRKLHEGNTELVKRKFAGLVERRQTNNITLPYGVPKEFDLGIHNGERCVVSITLLDANHCPGSAMFLITSKDKAVLHTGDVRADKVYMQQLMREPVLQEFLVPAYSPSPDPSPIRRLDRIYIDTSQSWVLLSLSLADHSQGRHPGHAPEGIVCSASPPLTAQEDSLREMIYCMAQYPPETVFFLNTWCWGWEEVIIAVAKAFKTRREVYQAVSTKLMEPVRTIKMGEWNLAGSDILAAAFRSTLQQASAGEIEWPTEILYSLHENFMGAVPDDAVLATQAETRAWFAASPKHGADWLMAMDLSVVDNADPPPFLGLNLNVNLNAGTNRNLGETNLHLNIGNPMSMLNALVGGPLLTNAAALFGGSTRVMPSGPASSAGLHASSRQPATSGSTSSVGRVPALTVKQEGEPMPKEVKMEIKVESEASTAKVLLPSKGPRKRRRPASKYAVDAGSLSKLIKREPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W760</accession>
    <name>K1W760_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W760"/>
    <dbReference type="STRING" id="1220162.K1W760"/>
    <dbReference type="eggNOG" id="ENOG502S0P1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_761154_0_0_1"/>
    <dbReference type="InParanoid" id="K1W760"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="364" mass="38791" checksum="DE05DDE4B3C10901" modified="2012-11-28" version="1">MTPPRAQVRSPPKLDQYELLYNSAVQSFVRRDHVKTQATLARLLDLTRALPRTSSPWYDVSSTAAPQPGDEWMTKTLKLAISANASLYSDPPRAPGALAPDVADRLPPASPRRMLGYILDLCVSTYGSSLLPPALVSTFLLATSGGLARQPTRRIRARDRGRPPPSPRRLGRGRAQKAPRERARGVPEGGGDLHRRSPLARGRVGDGARHARGRDGDGQQEEGGPVPAPAERAGQARLAGSVAGIQRPAPATGHPEHGVRGEQRGHSPPGRTPGAAPQRLDNLKQVTDTLLLGAVLRAEDPGRLRAIKDSGAVLLLLLECRVLVRLGRGGGEVLLGNGRDLVSEQGRGGDDEALAGGLGDRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W789</accession>
    <name>K1W789_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W789"/>
    <dbReference type="HOGENOM" id="CLU_033271_0_0_1"/>
    <dbReference type="InParanoid" id="K1W789"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="585" mass="64407" checksum="140F5BCF6366C196" modified="2012-11-28" version="1">MATTKTRKRRADKKRRSKLSSDPNDVSNNGSGGVPGHHRTSQAMSKASKRRARAKRTAVSASNPVAILDCYATSATAMQVDDTMGMPVVASSSGLSKLASQPEGEPARKLVGGSVNMLLKEPIGKTPGKPADRKKKRKKSSKQRKRSKAADNGATAIKSMPIIGNEPGSNRKTPQKPPHRPANGLANKQVNKQASKQVSMQADKRAQKISSKKLSESTGKQASKPADTPISTPAAENPFSGRCIYCKTMDALLALTAPVPMSPVLARPLEVTDLHSPTARMTRTQNPLLASSEDTETKVERWRRLVPSAASSSFSAPSMCPTYSTVFSVSTAKTSSRGSSEFGSSSSVFWSPPLSVASLPLPKSDNGVDDLRCAASDPLPASHNTFRYSAFPGLHKPTGLDHSPVHVRGCTDIDVVTALGDFYQDIDTVYRIPPEKTAKKRSIERYKQAILEADCDIMFAHRRRSAAAAKLQRLGVPTILYPRSRGWLRVKMVEERTAFLLREEVDEMRLSPLEDYPDDCKATILRIMRMRMALRSEFQFDSRGFIDRRGRYAPFDPSPKEMLAFSWDWVEEFWEDSLWRAPWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7H6</accession>
    <name>K1W7H6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7H6"/>
    <dbReference type="FunCoup" id="K1W7H6">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7H6"/>
    <dbReference type="eggNOG" id="KOG1560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787983_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7H6"/>
    <dbReference type="OMA" id="RLETMCA"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="eIF3h C-terminal" evidence="3">
        <location>
            <begin position="156"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37731" checksum="5F7242C6B438D79E" modified="2012-11-28" version="1">MEGFLDVEASRDVESVKLNSLVLLKIMKHSTDSLPAPPPNTFQQDRNLPPTTNLSSHPDALGVLLGLDLDGVMEVEDSFTLPAGESSFGPANSYSTRLLNHLAEVQTPDSPVGVYLSTHNGGFVTRGAVDLLVAVEKAAGRGKAILLIHDAGKAATSGDLSLKAFRLSDGAREAAKAGKWDSAALMENKLTAATMLTSLPLEVASTPLVQAFLATLTTPAEQPKPSLSGSQVPLPPAFQPLVNPLPHSLPEYLSNTLDAVTLHNHEANNLSFMQRQIAREKANHERSIKEREDENARRRKLGQPELPIISSELRGGTKEPSRLEMLCLQGQLDGLTKSMGAEAGKGLVRCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7M2</accession>
    <name>K1W7M2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00834</name>
        <name evidence="3" type="ORF">A1Q2_00836</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7M2"/>
    <dbReference type="STRING" id="1220162.K1W7M2"/>
    <dbReference type="eggNOG" id="ENOG502S3NK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054608_0_1_1"/>
    <dbReference type="InParanoid" id="K1W7M2"/>
    <dbReference type="OMA" id="WCERWGE"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="74"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="224" mass="24769" checksum="6BBF0DA5EB692ACC" modified="2012-11-28" version="1">MRARSDHNDCTTARRPCLLAVNIPLANDSAPPPTWPEDVVYLTRSRVDRAFPRELLPLLAPNGFNPKPVTFPAHLIQIKRVSDPKHPANGQRCLVAKKKLAPKELVIPYLGEIHATLTDGEGNVTGDPHAESDYDLSLLRLAAHHPSNPTNAEVSIGIDAAKMGNAARFVNDYRGIGSKPNCEFRTSSTEGYLRMEIWTLTEIKKGDELLISYGKGWWGARKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7N6</accession>
    <name>K1W7N6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7N6"/>
    <dbReference type="STRING" id="1220162.K1W7N6"/>
    <dbReference type="eggNOG" id="ENOG502QTEW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438718_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7N6"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854245" evidence="1">
        <location>
            <begin position="22"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="575" mass="62584" checksum="24B01AB697AAFF82" modified="2012-11-28" version="1">MVLPGLVRFFLLLGLLLGVLGAAPSSSAQPAKGTALAKPPYAPLTVTTAQARSGTLLPSGGGLTLNRTRPAALIKLPKLRAWSMTVWIADRGYDMSTPDLLPAYVPDVRVTTDPSKNFAFEERRSLEALSSGGTPGKANHVNRGGDTWRLAFDDGFANFTYGWDMAENQSLNVTTEDAVEHQVLMGFSLAADAESTAPPGNVTVYFQVVDLLDAEPTVRITSYRAETGFLGDTTDSNVLLFSPVIEAPELPQPQYPNYTLPGPYPDWPQFKPHSDAGSGPTAGMFGNFTDGNFTFVVQETAGADSLVTRALGKSVIALALAGNNTVFEATSWTHINLASGFRKYAVIDGLKPDTNYTFWIYDRDRLVIYPPALFRTKKPGFRCPLMLPTAMCPGIGYASPVADVQPGGQKYLTDIPDQFANVIAENLDTFSMSLTAQACGRDMYSYVSTCADCYDAYRDWVCRMVLPQCADADPAPFENITTLPTAPHVVPRSTDSPRSSAISYPYEYSELLPCIAVCTEVDRVCPLNLQFICPHRNFNANESYAFEGRKNGVNDGQARNGRPSIDRFGNRWCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W855</accession>
    <name>K1W855_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W855"/>
    <dbReference type="HOGENOM" id="CLU_289879_0_0_1"/>
    <dbReference type="InParanoid" id="K1W855"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1057" mass="112815" checksum="55C464E051206E78" modified="2012-11-28" version="1">MGQGCHLASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTLASLPLRISVLLRLWRLFHFASQSSSDSGVSSTSHLSPPPTELCSVEDDDDGSGVVDVCSSVEVEVFSSVEVEVSSSDEVEVCSWEEVEGCCSVVELVDSSVDELVSAVELDGVGSGEGEGEGEGEGEGEGEGDGVSEEVCSSCVEEEVVSSTELVEGAASEDVSCSVDDGSCWVDVTAEDSSAVDFWAEASLAVEGADPASLPSEPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8H1</accession>
    <name>K1W8H1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8H1"/>
    <dbReference type="STRING" id="1220162.K1W8H1"/>
    <dbReference type="eggNOG" id="ENOG502S0C3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379469_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8H1"/>
    <dbReference type="OMA" id="SWKPAYL"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="424"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="663" mass="71325" checksum="81CDF2C5C77E56B1" modified="2012-11-28" version="1">MWVSPSSTSPPPHQPSAPPPSRAEIERKLSVKSNVRDTPTRKPTRPPVPIPSNSTDSASTASTVTPVTGASSHPSNLPPLVINPIFGGQFTNSPMASPATPHHAGISGLSSIAESERQSSGRMSPVDDVTEGGGEGDDSDEDHGANAELERGAEIKSGFLIKKQERRKEYSLSRAIDLKQIHSVVPVHSENQKHPFAFAIVTSARTFMLEALSAEERNDWIRVINAGRKRLSEKDEDEARRRELKSEAREARTNPVPVPAPQSLGAGAELDTHAGTWASNMSGMSVSPTTVPGGYFPRGAGHGQPASLGTSPSLPHQMGNLALGRSQSITAAPPSAATVNRRLSNPIIPPVTGLHPPARTGLHREISQGSIDLGGPGASTLSPPNQNYFVSSDEDEPYFSDPRQGWPASGEAEGVAPSDIDPNKVILATYLMKKSRKATREVWRKRWFYLTSTNIVYTKSHMDSRPLTTVPLHAVLDVFSVESADSDDDDDASLQSERKPNRHTSLRSSGKRDAPQSSGQEQHVIRIVTNKRRYDLCAPSEEEEIKWLAAIRALINRERERQAPTSSNGASGSDQRTTPTKQQLNIPTIAQQPPTPSSLPPGSPIAGQSASPTKAVGDYIEAGVQIGTPQRFVPTHGRTRSATQTAKNAVADVVRRFHTEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8U1</accession>
    <name>K1W8U1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8U1"/>
    <dbReference type="FunCoup" id="K1W8U1">
        <property type="interactions" value="744"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8U1"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005318_0_1_1"/>
    <dbReference type="InParanoid" id="K1W8U1"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="605"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="835"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="976" mass="107578" checksum="EAE277EB5B69782E" modified="2012-11-28" version="1">MLHASKPLAARSVQPRSHQAFGVVTSPTANSSYDGRYAFVPGWEDVLVWDVKRGEQVAMWHAVGVTSPVSYLAPAPPPSESSASWPATFAVAYNDGAIRLWSWAPGAEASEIVTFNGHKKGINTLAWDADGSRLASGGVEGEVVVWDRVAEIGLFRLKGHRGAITSITFLPHPTQSATTHPGYLLTTSKDTYLKLWDLSTQHCVQTVVVGRGEVTSAAVQEEGAEDGRYIVITGSGDGEVKAWSIGKEGLAEGLKENEDGELVLPVCSLPLPTSTHAVSQIVFHPSLPLIFAQTTDKTTAVLRLRSEEEVAAKRARRAKRNREKGKKKGVTEEEVEVNDLAPVAWEDRVTTWCVIRANAKVRSFALSPYDGGKTFGVLLQQSNNSLEAYAVPVPQGKSKLADGSAPEPTKVHSVELPGHRQDVRALAVSSDDQVLASAANGTLKVWNVRTTACLRTMECGYALCCTFLPGDRHVVVGTKAGELLLFDVAASTLLSRYEAHKGPVWSVAVRPDGRGLVSGSADKDVKFWDFEMREDGEGERVVSRLGVETVYKTKQLALVHTRTLKMTDDVLCVKYSPDGRFLAVSLLDSTVKIFFQDSLKFFLSLYGHKLPVLSMDISSDSKLIVTCSADKNVKIWGLDFGDCHRSLFAHDDSVMGVAFEKNSHYFWTVGKDRMLKYWDGDKFELIQKLAGHQGEVWALAVSQQGEWVATGSHDKSIRIWEKTDEPLFLEEERERELEDAHDAALADQMNRTDLDGDADGEGGVEAEGVQKQTAETLMAGERIMEALELADAEREAWKEYETEVAHHRESGNEAAAAGVPQPQGSAELKARGVTPEEHVYQTLSKIPAAQMEDALLVLPFRNVVSLLGYLDAWARADRDIILTARLLLFLVKTHHAQIVANRVMRTQLVDLRRSVRSALEGHRKRMGYNLAALRFLRNRWESEQTAGLLEEENMDEEAVRKRIEEGRAKRKRVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8V9</accession>
    <name>K1W8V9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_00473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8V9"/>
    <dbReference type="FunCoup" id="K1W8V9">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8V9"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020932_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8V9"/>
    <dbReference type="OMA" id="NFQMEPF"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="317"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD05243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="548" mass="61293" checksum="F7161CA09CF59C01" modified="2012-11-28" version="1">MRGISALRPLVRPAPLPRAAYARALQARNFSGTSIRLNEQKKDAKEDKKDEKKEKEQKKRGYDEDAGPPQSPFKVFLQVFKEEIEKNQGWQQNVKQLSGEVDKMADSKAMKAAREMYERTRMANLMKENPRLAKAAEDLKKAGMSVNEAINKALADSEVLKAIAAASQSVSAFADRATQPIRDTEAYKQIAASVSEAFDDAAGTGARYGGYAEKEERRRKRELRAQKAGKKTKRVAENPDSRGVANPSGVTELTLSAGEALVVSANQEPTSSRLSFITESPTYQKLREQYYESENPAVESFRSMASTVAGWFGENETARVIRTIREMDPDFNMDSFTRELREYIVPEVVDAYLSADREALKQWCSEATFNVLWATMGQYIKQGLVSDSKILDIKHVDIVSGKLLENDVPVFVISFASQEVLCFRSAKTGEVIVGNENGVEQCRYAFVLTRIDKEVDNELTGGWKVVEMARHGQKSFIYPLTPPTNPPKPPKPYDRLAFAPFSMHTTILTSTFRLHAEYRRELNHKFSQNPDRVHGAAGKRTGAIGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9D0</accession>
    <name>K1W9D0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RB91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240004_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9D0"/>
    <dbReference type="OMA" id="TRHASHE"/>
    <dbReference type="OrthoDB" id="2570292at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="914"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="516"/>
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            <begin position="716"/>
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            <begin position="980"/>
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            <begin position="1065"/>
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            <begin position="1140"/>
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            <begin position="49"/>
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        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
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            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="281"/>
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        <location>
            <begin position="338"/>
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            <begin position="353"/>
            <end position="365"/>
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        <location>
            <begin position="413"/>
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        <location>
            <begin position="604"/>
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            <begin position="621"/>
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        <location>
            <begin position="1492"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1524"/>
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        <location>
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            <begin position="1684"/>
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        <location>
            <begin position="1697"/>
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        <location>
            <begin position="1722"/>
            <end position="1734"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98223.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
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    </evidence>
    <sequence length="1734" mass="192130" checksum="BF02FB86171E90AE" modified="2012-11-28" version="1">MSEYRNHPPPGGGSHHGSDRGPPPRHYQPLPDHYSAENHPTSPHGSYTAHRDQDYGRRYAPHDSMPRSYYKGMDATPPSRREVIASSRASVASYPRSEAGSAAPPPVPTPSEAEVALATSKKQLHAVTPHPPTPQPVVAPEPASEGRRSYMSGPTYGGGPTDTPLAQSAPAFTGPQHTTIAGDPQADREAEHVQPSGAPTVSTWDRGHKIVVPPRLRRPGMGFTTESYDANSVAVTRPRTWGRPSDNVPQDHEQPQSAPLRRPDPSQSETVESDFPTSPSAQVHPAPVHSSAVPRQTYSSAAEPEPIYQTRDAHGQASPIPAEFSHEKTLYSAHGQRQRVSSANYPQSLPPSVHQSQGPIRSDQQLPAGHPSPSVPMDQPGPWTTSIPQRAEPIPAPAVCVQSGGAQPPMAGHGDDQRDEHQFRRAQDEPARVHDRTRHASHEQPPPATEFNVPRHSTPRHVLPPKPAQECSPKGLASEHGWSLKPSVELTSDGAAWNSPNIQAWASNVNDTQQVPAMAVLSTEAADDNVSLPERPDSTKPMPKPVTLYISPDPSPEPRMPSSAHDPESSTLPMKASGGQNSPSPNSDDDEFDRPRTPSDITDADAHDEWKEGVEPESDPEFWKRETTHPRDSPRFQSRRVIVVSPFPLHKEGYSDRAAVVFQDSIVLLMNDRNRHDGSFQSAATSSAVPVRLQIYQRPAEDEFIGLWIKVTGDRHDDRSRSASPVSSHRQQSVPAGSDMRPAPPSLEVWALPTPSRHRRMYWKIELWDPRQGDFPHAGDGDGASRNPMRLDVIPLGRRELERDFLPKLVAFYCEVMEVIPPTETWQPWKFVVCRSWKIGHLIEDLPGFTIGKWNSNIKWRGDSPLPTFSPEPRDAHQLHNAAPNLKRRILPTYKGRPVRADTWRGIPRFVDDAAIYVGGIPAHESEQSLVERFSKYGKVVGIEYERRFKYAEARVMFETKRAAESAMLYERQEVLVDESGRVVNPSDTQGDDTLSHGKEQHNAGSQQPSVSLGGAAKEDDDFVYVKVPRLPTQNWVRAKLQVTFDYSESGEIQTRVHLCPSVPVASTSSTRDTTGSRTVSRCGTDATTTASKVKQATKSPPIKSDEFQPRVLSTKMEDGQLKPVYDPEDLKRWKIKKGLPLTDDTTPESTTTPPRDDAVSLLPVRTGGHAHPAAAPSTDPGYENPSFTQLEAKSKPMSTADRRDNSRLPPQAHREVFQGEQPREDIHYPGYRRESVEQQDQQVQGTSYVPAPSQRDRQPDYGAVPDQHRRSEHPTHQPSEPPLRNESRHVPVPQLPPAAPRVIEAPPQVQRPRPVIAPRPAHGEPWAEPRRQSDSYNQGGAPRERDTWAEPRRRSDNFYTGDVRPRESYREAGFIQSSQHIPYHAGQGQHEPAGDRHQQRDPRQFDAPRVRESAGGGHYQQAEMPRHNEPPRVHEPAVQHHQLPQRPQAEVPRYSEPLRAYEPAGQRSQPPEPPQAGMPRRDNPPRAQEPAGERYQHAERPRAYEPPRGGHQPTEPTRHRDHIRAYEPADGRYQHAEPPRPRDAPRSSDQDHQAESRSPAAPAAARNLQSQPPAASQPIDYDAKPPRHDLNPDYERKAPGHKEALGWSPSPAISAGAPGPPQPGPPQTAAPAQPTSPAAREPPVTRDPSQAGDFTPPVHIPDREDSARTPIARQQESSRRRQPAAPQARQPASRVMDSHSKEEHDHGKSVWDPPPREPSVAPSSKSSQPYGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9X7</accession>
    <name>K1W9X7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000072">
        <property type="protein sequence ID" value="EKD05573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9X7"/>
    <dbReference type="HOGENOM" id="CLU_877689_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9X7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
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            <begin position="172"/>
            <end position="243"/>
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    </feature>
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            <begin position="1"/>
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            <begin position="29"/>
            <end position="38"/>
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            <begin position="53"/>
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            <begin position="172"/>
            <end position="181"/>
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            <begin position="182"/>
            <end position="219"/>
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        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="35720" checksum="0D25D6427B9F95F5" modified="2012-11-28" version="1">MTVSPKDPRPGAASRRDAELPPTPDSRRSSSVSSNSNVEVWRAGMSSLKGYGSSPELPSLPSPSGTANPTELTERDQKVNITSEPKQGLSPVPDSDVERQLQEIDAMAFPAFASPSDTLRGDSRELVTRKSSNLFSTVQKRKAQWNNEAEIAKKRHLVTLGSAFLAPLTRTSTHQFKQQLPHSDRANSRHISDRDQRAGDRDREHNRDRDRDRDWDRNRRTPPASDRPPSPPPALPDFNDDTTVLLEIPPGTTQITPRMLKGLVARTSERRNAKFLHDRRSSRSNLCDWLDRLNDAITNGDLRVLDEELDKIERERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB67</accession>
    <name>K1WB67_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB67"/>
    <dbReference type="STRING" id="1220162.K1WB67"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="InParanoid" id="K1WB67"/>
    <dbReference type="OMA" id="MSMTGDY"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="275" mass="29510" checksum="52064A74A4A22404" modified="2012-11-28" version="1">MPAHPYSTPPEIKDDIVVLSYPLPHVLHVAMNRPKALNAMNAELNQALNATFDWFESEPELRVCILGSTNRKAWCAGADLVAWQEKGKSTGDILKAGFGGIAERFTKKPIIGAINGYALGGGSEMTVNLDLVVAGETATFGFPEVKRGVSVLAGGVPRFVRLVGHARAMECVLTGRNIPAREALGMGMINAVVPDDEVEKKALEIAGAIAENSPDSVVSLMYGVRIASEVGSVSIAQKLFADSPQVRALYNGKNIKEGLLAFKEKRKPRWEGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBG4</accession>
    <name>K1WBG4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_06777</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBG4"/>
    <dbReference type="FunCoup" id="K1WBG4">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WBG4"/>
    <dbReference type="eggNOG" id="KOG0826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031067_1_1_1"/>
    <dbReference type="InParanoid" id="K1WBG4"/>
    <dbReference type="OMA" id="QHYLARC"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC99023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="374" mass="42555" checksum="4DDF8BC9BEFC949F" modified="2012-11-28" version="1">MSHATPVFPEAGPSESPYRPHLVELIPQEQLRTVLHPVFRYVLTYLAQHYPRYFLRIVNRHEEAFALVLLLLEKHHLWKHDASLSEHFYQLKLAPARVHTPRLGSIHAQQPARLSNRQRWGMLLVLVGLPYVRARLDDFYDRWSTQNDPELSLADQGPPLTTGQKIFLKVYPTAVTAFETTLLAYDVAYLFEKTEFFRPWHRWLGVRIERAIDDAPPSSTQSFLSKLPPLLPPLLLALKFAQWWYSPTSPRSLPAASKSEEQSLHTSVLPPRPLPILPSSGLLTPPHSPEDEKQELKADPSEQTYQIDAKEFGHCPICKGKWQNPAILPSGWVVCWRCGWDAISGEGELGEAGKNRCPITGVAVNQSDLRRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCF2</accession>
    <name>K1WCF2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCF2"/>
    <dbReference type="STRING" id="1220162.K1WCF2"/>
    <dbReference type="eggNOG" id="ENOG502S4MX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514840_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCF2"/>
    <dbReference type="OMA" id="EWTFESG"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854328" description="Alpha-1,2-mannosyltransferase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57477" checksum="545398434D70E267" modified="2012-11-28" version="1">MAFPIPPILRRAPPFIPLLLLLLVTSLLLLGHPTTRQHVVPSSWVGGSGRGGPVGISATDEAPLPKEYEQWFPSGQLPHELDGEPRLGKALKAFLRRPALSHDEAANHDHCPAHLAKLLVNPDQLKNDGPFWRALKPEEIRQKRAELVQYLAARQAEGYNLVHSDGENGNSTGKGRGIVLTAGNKDTTERAITLLRMLKSYGNTLPIEVFHYEGELTDAGQRSAIEELGGKVMQVRNAEKKAGRWKNWQIKSSAMIESSFREVLSLDSDNIPLGKVEHLFDADLYKNHGGAVFWPDITKDHPDNAIWRVVGEPCSFDEWTFESGQIVFDKAGNGGLNLAALWLATGMMADDAFWFKLCGGDKDTFRWAFRALDIPYARSQRWLSALGYLQNSGSFCGHTMLQYDITIPEGQVNYPPLFVHSNLLKHLGAEQERPIFKLIKKMKVDRASEPSLNYALLDVKLSPWMCTDLAIHPHVKPDEIKDNFVELQDISQVEGNPFDGFEKLFFESGGMVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDK3</accession>
    <name>K1WDK3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDK3"/>
    <dbReference type="FunCoup" id="K1WDK3">
        <property type="interactions" value="683"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WDK3"/>
    <dbReference type="eggNOG" id="KOG2062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002323_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDK3"/>
    <dbReference type="OMA" id="HENENFK"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="775"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="820"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="966"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="835"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1017" mass="110412" checksum="170983DE02E2FECE" modified="2012-11-28" version="1">MPVATVTTSAAGSLALLKDEDRDVRVYALEYLLGIVPQFWAEISEELPYIESLADPQFSQLPAENRSLASLLCSKVFFYLGERDEAVEFALRAGPAFSNLPYDEFKETIIAGCIDRAIDDTEAGRTVDTRLEEIVDGVIRSGSGDGAKLAIGLALSLRRLNLIEAIYKASRAPAESSASGSKSTSGTVHDESLLRYILAETIGGTAGSDSWPDSFRRDLLSLLLKLFRLNTPSDYNAITQLWVQLDDAADCAQGIISLLADGGVQGRVEAYQIAFDVTEMAPQSFLERLRTVIAESGWGPEGSKGDEEQRTALHEILNGNRIAELYINFLKKHNQTDMSILKGTKDSLEDRYSIYHSAITFTNAYANCGTTSDRFLRENLDWLGRASNWAKFSATAALGLIHRGSYINGVRVVKPYLPGGTAPSKFSEGGALFALGLIYTGRKAGAETELRQGLDDANDPIVQHGAALGLGVSALGTGDEEIYDELKNLLFQDNATSSEAAGYAMGLVMLGQPNERVLDEMISYAGETQHEKIIRGVVIGTALTMYGKRHGASDVIQKFITSNDAILRYGGMFTYALAYVGTGDNKVIKQLLHFAVSDVNDDVRRAAVIALGFVLFRNHTQVPRVVQLLAESYNPHVRHGATLALGISCAGTGLQAAIDLLEPMTKDPVDFVRQGAYMALAMILIQQTEAQSPKVKEIRELFQKVVTDKHEDPMARFGASLAQGIIDAGGRNMTISLATRAGTPDMKAIVGMVMFVQFWYWFPLAHFLGLTFSPTTIIALDSQLRIPKVDFVSWAKPSMFDYPSTAKPVTEEKKKKAKAAVLSTTAKAQARARSKKAEAGEAMDTDDKPEKDEDDSSPKKKERKAEPPQAVVPNMTRVTPQQLPFITGPYDPSSLKGKEKEDSLAPLHPKKGAYRPVRAVGNYAAYEADKLSDGRARVQWSGKVLLLEGEGSDGFIELDAALWPRGAVDEPASPPTPTPIGGSAAIGTAPPSYSASQSFDWDGEAPASFEYEFDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WI16</accession>
    <name>K1WI16_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative EF-hand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WI16"/>
    <dbReference type="FunCoup" id="K1WI16">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WI16"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_18_2_1"/>
    <dbReference type="InParanoid" id="K1WI16"/>
    <dbReference type="OMA" id="EFFMIMK"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005825">
        <property type="term" value="C:half bridge of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="18878" checksum="C4F991DC2FBCC2AA" modified="2012-11-28" version="1">MSGFPRTSRRGASLPPPKPSLTDEQRGEVRDAFELFDTDKDGFIDYHELKVAMRALGFDLRKQEVLKILRDHDRGDGLMALADFEKVMTEKILARDPMEELRRAFSLFDDDKTGRISLKNLRRVAKELGEHLGDEELQAMIDEFDMDGDGEISQEEFIAIMLDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WI69</accession>
    <name>K1WI69_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WI69"/>
    <dbReference type="STRING" id="1220162.K1WI69"/>
    <dbReference type="eggNOG" id="ENOG502QS8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012617_0_0_1"/>
    <dbReference type="InParanoid" id="K1WI69"/>
    <dbReference type="OMA" id="HAMSRMV"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="488"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65444" checksum="8450D7AACDFCA096" modified="2012-11-28" version="1">MPSGDQSQDVFRIAAFSGFTGDNWRALKQQASQAPVLFGDYLAEMRTRDPSLGYEQPFLQHVRLAADEIKTYRPKILTNAGALNPRGCAEAVSRLFAELGIEGMKIAYVEGDDLMSRLDSLAEAGEDFHHLEDTERKLRDWGLKPASANAYVGARGIYEALKAGADVVISGRCTDASPLIAAAAWHHGWRWDEYGPLAGALLAGHCLECGGYVTGGNSSGFLNIGPYHDLTMGIAEIARDGTFLVTKQPGTNGVVNANTVRSQILYEIQGNIYLNPDVTADIRDIVVTDLGNDRVRVTGVKGLPPPDTTKAAICAVAGYQAEAMIFATGLDVEAKFAAHREQIRRYFGKELAKFSVFDMTQYGVAATNPETEAQGTAMMRILAQSRELDAFGPTQSLWPFVNPEGLGHYPGFQWQLDLRTAVPTPFMEYWPGRVRQCHLPLEVRFVGSEEKITASPPDHTAPRVISEDYDSTEPCASLEQGATVEGPLGWIVHARSGDKGGNANVGLFVRHEDEYPWLKALLSKQGLIKLLGKEYDGYRVERVEFPGMLAVHFVIHDYLGKGVSSTVRMDSLAKGVAEFIRARYVDLPARFVERGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIG2</accession>
    <name>K1WIG2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIG2"/>
    <dbReference type="STRING" id="1220162.K1WIG2"/>
    <dbReference type="eggNOG" id="ENOG502QTWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="InParanoid" id="K1WIG2"/>
    <dbReference type="OMA" id="VGQIHDI"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="327" mass="34595" checksum="CD27AD8AF16DD3E8" modified="2012-11-28" version="1">MFVASGPRLAAAVTNAGGLGVIGGLSMTPKQLRMNITELKSYLNDKNAKFGVDLALPKIGGGARKTNHDYTHGHLDELIDIIIEEKTALFVCAIGVCPPAVVEKLHKGGVVVANMIGHPKHVAKVCDAGVDMVIAQGGEGGGHTGDVPFSILLPAVVDAAKGRKSPSGKDIIVLGAGGVTDGRSLAAALSYGAAGVWVGTRFVASVEAAAPKAHKNQILSTQWGETTRTVIYSGRPLRCKKTPYVAEWNDTRQKEIEELTSRGIVPHMHELEKHPERSIEGKIWIMGENAPRITEVLTAKEIVDELVEGAVKSIQTCAADLRGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WLM6</accession>
    <name>K1WLM6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prephenate dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WLM6"/>
    <dbReference type="FunCoup" id="K1WLM6">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WLM6"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_5_0_1"/>
    <dbReference type="InParanoid" id="K1WLM6"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="277" mass="29983" checksum="2A7E726107C3B45B" modified="2012-11-28" version="1">MFRSLATAMSKRMAYLGPAGTYGEQAAKAFLARLPDKNVELVPCPNIRAVYDDSAEYRVLPLENTLQGAVIETVDALLSTLGQAKQANGSTRPRSAVADTALQISHQLVGLKGATLADITHVRSHEQALGQSASWLSEHLPNAKREPWSSTAAAVASIMEEGDKSGAAICSKSAYENDKNRLERLADGTQGDPTPKSDVTVSFYAVPESRLIQDVKGELVAAHSRPAPQGWRSETRTSRRAWPVWTLVEVRGDAPAPSDAVWLGTFKEDPSTYQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM92</accession>
    <name>K1WM92_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000295">
        <property type="protein sequence ID" value="EKD02244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM92"/>
    <dbReference type="HOGENOM" id="CLU_855780_0_0_1"/>
    <dbReference type="InParanoid" id="K1WM92"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37026" checksum="65936088E1894DB2" modified="2012-11-28" version="1">MVTIDIAFFPHIFDSIFEASDHNALIRLRQTCRALRSRIDDDWGHLAWLVKDDRPYGAVNRRGLIIPCDSPCVRLTTVLDICHADDWCDVNEVPSCCRPEVIRIFCLGIIPLTACTKTIIILDQECGDIAGYYMEPPPDPQFSINIIYQLDCMVWEGSEGRCPPFFSYVGRMKRSADVYLLLSGCNPTGDCVKDLCYFMMESLTGYKSGVQEGEAPLGYEHNFYFVDVPSWFDTSITDLPNDDSERLDRILTTPSTFHAHMLAEAGYEEGLEDGSEAEYARHWPHLVVLERVFKQVHCISREQMRKRVGDKAFDLAFAPPMRTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMZ8</accession>
    <name>K1WMZ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMZ8"/>
    <dbReference type="STRING" id="1220162.K1WMZ8"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_10_6_1"/>
    <dbReference type="InParanoid" id="K1WMZ8"/>
    <dbReference type="OMA" id="PRYMDFQ"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="217"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="311"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="315"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="435" mass="49921" checksum="DB1568A68E113D96" modified="2012-11-28" version="1">MSAATRAKAAAITSTKPSQPVKAGSKRNVLGAVTNIREDHGEVAKKPARSTAQRQPLSNRSQTFDNNRGTTTTRATRAAAAQVFAQPEPVEVEVVSRETARIDLQSNNVIVEDEYEDDEKTVGARSDDMDEDEDDEFDDEDWLRMSPEEELAARQELMAVKDTFQDDIDMFDTTMVAEYADEIFAHMEEMELATMPNPRYMDFQSEVEWTMRTTLVDWLLQVHLRYHLLPETLWIAVNILDRFLSVRVVSTQKLQLVGLTALFIAAKYEEILAPSVDEFVYMADNGYTKDEILKGERIILQTLDFNISAYCTPYSWVRRISKADDYDIQTRTLSKFLMEVTLLDHRFLRCKPSMIAAVGMYLSRKMLGSDWNDAFVFYSEFTESQLRTAADMICERLVEDGFERVFVYVKYSSKKFLRASAYACDWAMTNYRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQB1</accession>
    <name>K1WQB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQB1"/>
    <dbReference type="STRING" id="1220162.K1WQB1"/>
    <dbReference type="HOGENOM" id="CLU_1732784_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQB1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="151" mass="16250" checksum="E97245ADAF5281BD" modified="2012-11-28" version="1">MTARVGRSVVPVRSSLTISIVGALARRRADADELSDEDKRDTKVSCVFSTGPNRLALAIEHSMTRQTQTAADVRRAARDGLKGSTAGLAPGHVQANLIILPERYAKDFRNLCLRNPVACPLLAETKPGETRFPPGVADGIDIRTDVPGYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRZ2</accession>
    <name>K1WRZ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRZ2"/>
    <dbReference type="HOGENOM" id="CLU_1278436_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRZ2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="216" mass="24014" checksum="981A283EAF78CCE4" modified="2012-11-28" version="1">MASLAASLPRGPEPAGFAPIWHWRWRPPLSSRPPAWLAQRLSLAHHPYPSYITSRRPLPPAGFWSTPTPFSLPSHHPSRLPSTPPHPSISRILVEIDCTDGSASTLPTAPSSSYDTPSPPISSRLRYQFRFESPKNRHRRRPSLIHPDARYSINHSTLSLLCRSIPPAPSPSPACSLDPQFKFSTDSRPLRPDTASLSIILVGLKRRLENRIPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSR2</accession>
    <name>K1WSR2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSR2"/>
    <dbReference type="FunCoup" id="K1WSR2">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSR2"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036100_2_0_1"/>
    <dbReference type="InParanoid" id="K1WSR2"/>
    <dbReference type="OMA" id="LDMKWLP"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="380" mass="41399" checksum="78C9A69B89007C33" modified="2012-11-28" version="1">MSEADALATVDTEYTADSIEFCPHAGNEQYFTCGTYQVIPVTKPTKAANGSASENGQPNGSTNGTTTEYSKVVDGDDSESDSDEATPPAPRVGRLYLFKLDGDTPIEVQRTETAAILDVKWSPTDSALCVADAKGAITQFDFADGKLSEKSKVQVTDESRLVLSLDYAKDGKGLISSLSNGALAHLSARPEGWEVTEEWHAHDFEPWIAAYGDDQNTVWSGGDDCRLKRWDLRAPQMATFINKRFDAGVTTIAPSPYAEHVLAVGSYDSNLRIFDARSPGLPLLEMELPGGIWRTRWHPSSERRGDILNACMHGGFAVVRLPDALAGGELCRRVDQGEIISTFPGTLGYGADWCRRKEDGPTSTVATCSFYDHVMNVWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU01</accession>
    <name>K1WU01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU01"/>
    <dbReference type="eggNOG" id="ENOG502RZ5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037534_0_0_1"/>
    <dbReference type="InParanoid" id="K1WU01"/>
    <dbReference type="OMA" id="WRECIKA"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853145" description="Glycosyl hydrolase family 88" evidence="2">
        <location>
            <begin position="17"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="45809" checksum="8585D0DCEFFEB174" modified="2012-11-28" version="1">MLKTLGALAALAVAGAAPVPTLDTREYPSLSYYGYMNQPSSPATSTARLPVINKASQPIEFHDASNEGAVNANKARAALMRAEGLSHKTWEVSTFFQAKAELYGVTEHNWSSKAFAAQQPGDPAVREATDKLGALLDIAGDGYLVNSDRGSQADVFSLVPAVWASGKQDAAKNMVAWLRTQGVRSGDIYSHRGDRQSLWSDEGYMIPPVLAFLGLVQDDVSLLSEALEQWTKVADALADERGTFRHVPSEFDPHAWTSGTGWMLMGLARVFASITEAGHEAEFTAQINVAKDMARRALFAAYGAQTPDGRIPNYSDRDSPAETAGTAAVTAAYYRLLLQHPSTFGDEWLFAAAEKAYDGVMKQVSDDGTVSGCVDPSGADFNNANISDSPEGHAFVPLMWAARNAWLGHHPDGKLPKGQQEQTGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUD8</accession>
    <name>K1WUD8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUD8"/>
    <dbReference type="STRING" id="1220162.K1WUD8"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007694_1_2_1"/>
    <dbReference type="InParanoid" id="K1WUD8"/>
    <dbReference type="OMA" id="NIWRIAH"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="452"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="801" mass="86460" checksum="86F5735F16E1C326" modified="2012-11-28" version="1">MSVFRRSSRLPPVSDSDDTSPSTLAAPSVSVADSSDNLSALSTPSTLSVDKSSSRLSAAPKANSRLSPLRIVSRSRSQRDSGTIASPPIAVPPTPTDPNTDKKQPPVETMAADDDTHAQAPASPPPEGAPGTAPVVGLGAAAQVAAQQQRAGRHAHRDSIVQRVAERLQSPHGHGEGKRRRRRRASTTSTAGTGASNMSRTPPVLPASASTNGIAAALAKSGLQITGDEQILKASAANRAVSSAGRSPYLVRQDYESDEGYGSEDESDVLTDDEALDNLPVTGFAVASNRRNAEFHSLFPTVDEGDYLIEGETFRRSSLTTDYGCALAKDILVHGRLYVSENHICFHSNLFGWVTDIEKKMTALVIPNAIGVYTSKERYTFASLISRDSTFDVLMNIWRIAHPDMEMTSSTAPNGADDAASPDDSAVDDSAAKAKGLPHKSTQCDCSKTGGHYAEVALDTTFPSTPEKVYNLMFNSGWYRTFMSESQKLRDDKKLMRTTSYIKPLYGSIGPKQTKCHIVDVHEHCDFDSYITMVTTTRTPDVPSGGVFSVKTKTCFTWASASSTRVLVTTEVEWTGKSWVKGIVEKSAVDGQKQYHEDLAREMRAYMKEHQSEFAVAGAEPDSEASEAAPSEAEPSGPTKAQAYAEAAGRRGKKPEDEYWLLQGCLDSITSGFSMIASGIGTGAKLVTDMIEESRFSKTSLMVGVIGLLLLSNVYTYWNRPASQHKVKRLQRFGPSDDAVTEAVRQILARRAATTPKEEVAQLVHMLDEIEARAANLRQLLLASSAVDDDREGVLVINEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVB8</accession>
    <name>K1WVB8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVB8"/>
    <dbReference type="STRING" id="1220162.K1WVB8"/>
    <dbReference type="ESTHER" id="trias-j6es27">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_2_1"/>
    <dbReference type="InParanoid" id="K1WVB8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="89"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="550" mass="59294" checksum="6F6D7E93AD37449A" modified="2012-11-28" version="1">MKQQPYGSSYLSSMGVGAALQSALIFAVTLGLSLLLRYFSGLDTDRATGPCQLRWGGVTVEGYLGPNNVCRYSIQYSKTVRWGEPRSVTTDGSGLPPSCPQSVVFGSRFRGLGVPESEDCNYMLLFIPQNADASTPIFTWIHGGSNWMGSVSMPGLDGFALAGKGQIVVLPQYRLGLLGMMPPSSHPTSLDPNLAVRDLAFMLKTIHDNIGTQGNAGAITISGHSSGAAMLRSLWQVPSAPGLYHQVIVHSDPSVFPTSSMEQHKVVRDKVYSFNMFKGSKTLQSLKELDVRAFQHAIDQLMAWSGSVNTPTDILNPVFGTMTIPYEPTRALHGDGHLSVRPRDVPMLISTTKDDGGYVVSSNHHQPLSVALDSDGLSPFLRALAGRCANDPTSQPFISEEKYRIGSYTDGPDVGRVALTDIITDGAFRCVGRDTASHWAKAGGKTYVVEINDSAPYLWSSMVGNDWCIGRDDVPNVLGYDNGATPGLGDEVSDVWSAFIQGRSIGVDTYKPDANQQNTNVKVIGGGGGEAPNCPIDFWGTKCTWAWQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1V150</accession>
    <name>K1V150_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1V150">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V150"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004488_0_0_1"/>
    <dbReference type="InParanoid" id="K1V150"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="987"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1094"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1474" mass="164399" checksum="1DED6678F6F28436" modified="2012-11-28" version="1">MADRDRLSIDTSTTAGAAPPPPAVSAGASQASSSRPSPVSQLTTFPNPFQDEPEPGLLPSLISKVKSTFGGATPQAPPPPSEAQQIAEAARKSGVGQGTKPTGPKPTQKPPAEAPTAPAPKPKQPAPPSSSQPTSASSSAATSVAPSVTSAPRRHLMPGERWRPAGASPAQVTVSPITSLTTTGPQHPEGLTPIPTTAPSVVPSFTNQPATPALPQIDITNAKGSAIHRIRRGSISTIPDSPSSASLNAMMSNPSDYNNFSFVPGFQLPADDTRSVRSFALAKRPGSVSKIIRRMRGEGLSKHYWMADENCKECYDCKSVSDQICVRSDWQVFTTWRRKHHCRICGQIFCGRCASNIIGARRFGQDGMVRVCNLCLKIMEDYDDEDDRRSISSGISSLPDRVFSPEVSYAQSPFAASQLLRSHAANESLSAIDETDVPRYWNRDPDRPFTPEGVSEAGSDTEEDGLWTGARPSTAAPFRRQDDEASDDHHNQVVPHGTPPNLGNEGDRRDFPTTPHHFFPRTETMDSETDPRYFALMDSTNGRPGIRSRLSSANSVLGINALLDSDRKDGLWRARSQSFVTPPEFLCGPSLAHFNTMLQQAIETADLSTPAQWHRVLGRLLLRVSTNVRPVLRAGDSIDVRAYIKIKKVPGGKISDSEYVDGIVITKNVAHKGMSRRLVNPRIMVVTFPLDYHRVETQFMSLDPIMKQERDYLRLLTKRIIDLRPHIVLAERFVSRIALDYLYQANIVVARGVKYSAVHQVARCTHADIIASMDRLALEPRLGRCAEFRVQTFENEAIPGRRKTYMRFEGTHNGFGGTIILRGGELATLRKVKVIADFMSLVAYHLKNETFLYGDEFHMLPPHPPMPQKYQELLAMLAEDEVPSKIYGRPVNSTSNEEDSDELTPRALPERDEERADALRLTKDIAESLRPYLVTVLSASVAVRFPPPHPLAKMADLDRQLNHLLLQKDEKEAQQILQEELRIPSGRFEAIEDEKDKAQEKEKPQEKGKEDEKESKEDKDKSNDEEKQPEADATPKKAPEKPALGEPIIEEIGSDTDTEDEKVLSSNNETPRADDTPRAERTEFKPLTPVAMDSSPESSTSSKRSSQLGPAPSTAAPSASTAPTSIPPSSSVPSTSTPSQILPTPASKGDPYRVLLNPADFEDATKLAFVEYEHAEQLKVWEHYVRKHDEPLDPQNYQGIIYTQALFRQGQDKPCTEFARQQINYYQDDDQSLGQFLDGMVNNAGLRCPGKNCEQLMLFHYDVLVHGERRLQIVMEQFMCPLVGHEEQILTWSYCRQCNKSWEPQVMRDETSRISWGTYLEHCFYPPQTNTGFGCTHDAYREHIRYFAHRNMVIRIHNDEIELFEPVRPPTKLLVRVEDKVRIKNQEYESALQRTAAFFDSVLFRLRSFSEELVHPEKLSSMRVERDALLARAVADRDEMVNSLNRTYKQTPPTDVLAINVVLQTLQEKVIQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4T3</accession>
    <name>K1V4T3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanine-glyoxylate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4T3"/>
    <dbReference type="STRING" id="1220162.K1V4T3"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148836_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4T3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="129" mass="14040" checksum="1B910CF6685FECC8" modified="2012-11-28" version="1">MYSLRQGLKEILEGDLSFEDRLARNREVSNRVKDELEKLGCGFVPLSRDIAANGMSAVRYPQGVTAADVIPKLAERDIVVAGGLHKDIASEYFRVGHMGVTSADPSRGDVDKIINGVKAVLDEAKKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5D6</accession>
    <name>K1V5D6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein sorting 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5D6"/>
    <dbReference type="FunCoup" id="K1V5D6">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V5D6"/>
    <dbReference type="eggNOG" id="KOG2066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001285_2_0_1"/>
    <dbReference type="InParanoid" id="K1V5D6"/>
    <dbReference type="OMA" id="PQLVWQD"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="267"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="794"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1136" mass="126088" checksum="DC95549C5E8AA8AB" modified="2012-11-28" version="1">MPKKNKRAKAKAKAKAAPPKPAPPPAETQEEAPSVESKDVSDAPEQPPKQKAESVGGDESDTTEDGDEAPAEPNVDDKAADATEPIADPPKEEEKVNEPIEPSTTEPSPDTPEEEKGEEGEEAKSKPASPRPPAESSKDNSTPESEDAEEDTAEATAEATTIDKQEDEVTASPIGEAPKEDPPKAESIADPDSDTSAEEDDSDEEDEDEEGDEEGVDRDEEEEEPVGAEREAESVGEDEEDDTDGESEDDEEDEDDESDDEDDDEDEEPATALDVSSRVVALGTQNGMVHVLTYEGAKVNSFRPHAANVTALRLDEDNDFVATASMEVIHSLTSTESYAFDYKRPMNAIALEPGFAKSKNRRFVCGGMLGNLVLQEKGWLGYREQILHSGEGPIWAIEWRGNLIAWANDHGVKIYDTVSQQRIGYVDRGANAPRAELFKPTLVWKDDRTLVIGWADYVKVVRVRNRPKGQQGLPPLSIEVLSVWEVDCMVAGLAPYHTSGNVILAYIPPDTYENEATQDRAEQRRKAANRPELRIIDRGDEIAADELAVASYELYGCNDYHLAASKRQDDVDVFLVLTPSDLVLVRPRDAADHIDWLVDRERYEEALTAAEELQAKHGGALDVQAIGLKYMRHLVSEENYEQAASLAPKVLRRDAELWESWIYKFAQHNHLEDPVLSPEVYEMVLNHLLLNDNTAWPTDVYDSDKVVSAVQSELGATKDDPVLLEVLAELYIGRNQPARALPYYLRLRKPNVFDLIRDYNLFDAVREQALLLVEFDQERIKNDPQAKEGKHGAAIELLVNHALAIPVDRVVKQLSAKPQYLYMYLDGLFDADPAACQPYSDEMVSLYAEYDHSRLMPFLRASNFYDLERALRICESHDYVHETVFLLGRMGNNLKALHLIIERLGDVRLAIDFAEEQRDDDLWEALLAHSETRPEFIRALLEHGGEINPVRLIQRIKEGLEIPGLKPALVKVLQASNLSVTLLEGCQRILNGDCSGLAITLQRGQVTGAHATRECSLRSPALPFVQLTPATSTCAVCEKPLFDASKTSGPESLVLVYLCRHPVHATCAVLNDDTELPERPENAAALRLLLADNAPNAAHLSSHRAQQRALGSKLSYEAMDGRYSRDRREGRRLIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7K5</accession>
    <name>K1V7K5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7K5"/>
    <dbReference type="HOGENOM" id="CLU_897677_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7K5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="310" mass="33860" checksum="1D032359C5F99F33" modified="2012-11-28" version="1">MPPKKPTAAPSRRSLRTAKKIPPRDASTALSTPPLEIDKDEIQPVKSKVQRKADKDKSAPTLHEDDTIESGHAAMSSAQIEDLFNSPSPSTATKRPRPTDDNAVPYKKAKKEINRSNIAPNALLDNDNGATLSLDDVADIVQRMHDCADNLEDGASKIKKAEVLFDMFVGKGSRLPTIPRCLTDDHIRQAFGMDPLDVSAAALQERFGCQPGAQMPFPPDHLDGTYINDAVTSIWEADSMLVTVQTRHVGFKQGTVHVVGRERTPPDSALPDMLPRERTPPESALAGHLEISPYDAAKRTLAVSDNEHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8V6</accession>
    <name>K1V8V6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8V6"/>
    <dbReference type="HOGENOM" id="CLU_2005511_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8V6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="124" mass="12456" checksum="900E71EAB30032C7" modified="2012-11-28" version="1">MAPVRRDLNPGGLTGGSWWYPSEAAHVPMPSESALDHGLGASGLTTGDGSLPVHGGGVIPHDGKLKLTHGHVEQVKNDDTDTSSTSSASTTLAPSSQPTSSSPLRRRAGVGAVVLGIALAVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAF8</accession>
    <name>K1VAF8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">A1Q2_04702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAF8"/>
    <dbReference type="STRING" id="1220162.K1VAF8"/>
    <dbReference type="eggNOG" id="ENOG502RSAS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488948_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAF8"/>
    <dbReference type="OMA" id="RWNSTGP"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="182" mass="19062" checksum="DA1D0CD9BFC31735" modified="2012-11-28" version="1">MFARSLRSAAPAVRALHTSALLRAAEKSAAELALRDALKAAMKAKDKPAVHTIKTILSDVTNLAKTGPNPDQPATQEGVINTIRKGIEKRKSAAAEFDPNSEHAASLLAEAQLLQSYMPAGPSPEAVQAIIDEIVAGLPADVRSGRGATGQVMKALWERLGDARAAVDKKDVAARVQAAIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAK3</accession>
    <name>K1VAK3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase ESCO acetyl-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAK3"/>
    <dbReference type="STRING" id="1220162.K1VAK3"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073121_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAK3"/>
    <dbReference type="OMA" id="AIYMADY"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="306" mass="33212" checksum="A52C195B520B9589" modified="2012-11-28" version="1">MLFTPSPPSTPPKVLKRRATSEPTSPSPKKPLADVDTNRSSSPLTTSSTPKLPPVPAKPKQGTLLGFITRKPATARPTKRPRDDELAEKKVKPKRNEQLVFTQGTRQTCKQCNMAWMRGVDDELHAQHHSRVLDGVPVTKAQSFSWTLATSKPLAKGSAAIYMADYTAGKVTEACDAVDRVLSAATLPTEVREKCKVFLAVVGTRIVGVAVSQPIKHAMAVIEDSGDAVKCDPKRLPTPLGIHRVFTVPSLRGQGLAVAMLDAAAGHTVYGRSFKPEEAAFSQPTEGGRKLMRKWGVTRVFEEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAT0</accession>
    <name>K1VAT0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phospholipid-translocating ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAT0"/>
    <dbReference type="STRING" id="1220162.K1VAT0"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538825_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAT0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="506" mass="58138" checksum="33FF5C7B698897AC" modified="2012-11-28" version="1">MIQAADVGVGISGEEGLQAVNSSDYATAQFRFLKRLLLVHGHWSYFRNSTMICNFFYKNVVGIGVLFWYMIYCGWSTTYVYAYVYLLFWNVFWTLCPVIAIGIFERDADEDSLMACPPLYRYGREGKYYNWPRFLYYLWEGVYQTAIIYFILCYTYHVTTTRGDGWEVYKDEMSTTMAIGAVMAANLFSGLNIDAWSWWVVFAVWVGPFLIWVFTAIYSIVPPTTYFSGVYGNDIFLFRSAACWFGWPFVLIMSLMPRYLYKYWRQNFGTNDIDLMRLVRKYNPNVNVYTDPRLGGHFKREVAEVEAPLDRYPTDGYGHHYNDNFEMMAPYDEGNTSDSFQMDDMHRRPSTDSRHHADHPVPQYTGAAPARPSFQSARPSFQSARSSGRGSAIDMSTGLSQQPSRGFGFTMEENGVAIRRMQSRLSQASVERGKHYTLRRLAAQNRRRNAENNNSEPGTSPFGKLRTRAGSILKGSRNRSSTLKSHNTATSSEMHGLSETLDDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB66</accession>
    <name>K1VB66_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate dehydrogenase substrate binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB66"/>
    <dbReference type="STRING" id="1220162.K1VB66"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_1_0_1"/>
    <dbReference type="InParanoid" id="K1VB66"/>
    <dbReference type="OMA" id="GVVLEMC"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="327" mass="35717" checksum="36A932308D6C6613" modified="2012-11-28" version="1">MTIQPEAAAAAEGSTRTQFYLFGYPISHSASPAFHNCLFAASGLPNHYQLHDTVHPENVDTDVKSDMLQILQQDTFGGFMITRYLDRLDPGASEIGSVNTIYLERDAAGTLRTVGENTDWLGVRNAIVQSLPSFQQALSRPFGDDKAGFIIGGGGTTRAAVYALSQLGLSPIYLLNRDASETEEIIASFPQYDLRPLTPSLVPSIADTIAAGVGAIPCLPPQTEAERAVYATAAELFRSGPKGRPFLEMCYKPRRTKLYAMAEGAGWTAITGIEAMIEQGFAQQELWLLRSVARPWDRTDLPEHAKEKARQLVRGMDDIPPAERDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC44</accession>
    <name>K1VC44_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC44"/>
    <dbReference type="STRING" id="1220162.K1VC44"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="InParanoid" id="K1VC44"/>
    <dbReference type="OMA" id="GWTETAH"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34181" checksum="07FE7666DA178C49" modified="2012-11-28" version="1">MSEPIVPPKVPKTYSELPVRHIRIKNHPENAPGVTPIQIVELFRPGKHNAFTYEMAADIVRTWDTFAVDDRVKVIVLAGEGKIFCAGADLSGAFQRSDDDINGHRDTGGQVALAIYRCPKPTIAAMQGAAVGVGVTMTLPATIRVAWKDAKVGFVFSRRGLVMEAASSYFLPRLIGMSRALHLVTTGAVYPASSKLFDGLFSELLDTPDQVLPRALEIAEEVAANCSSVSIALMKEMMYRGTDSPEAQHLLDSKLIFDLYGTPDIKEGVASFLEKRPVKFTGTLAADAPVHYPWWNTVDVRTRKQDKRAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCJ8</accession>
    <name>K1VCJ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCJ8"/>
    <dbReference type="HOGENOM" id="CLU_1103425_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCJ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="28163" checksum="A777131D4BACEA1D" modified="2012-11-28" version="1">MSSNQYHSPALSTAPDSEAPVSGNVAANIKPQIFLHSPKELHDEYTWRYNHVKLFYNIARATVWDDIKSSPNSHTTLLEKQLEALNEWEMDELECLKDNRQFQIRIWDLNMIRNHGQLESVTHASSAEEEHLHMLEILLFQDMTGHNDNTARSIGGTTNGSLATLLSFKLASPMAPQIQATKYYDWTDRMSVVMAQRELLAYRREPSGASLLGTSEDAAKTAAATGPRTRASRIAPQLVADDGDLPGERSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCM9</accession>
    <name>K1VCM9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCM9"/>
    <dbReference type="FunCoup" id="K1VCM9">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VCM9"/>
    <dbReference type="eggNOG" id="ENOG502RIW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152072_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCM9"/>
    <dbReference type="OMA" id="GNYYEDK"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="76" mass="8463" checksum="134F9EB40FF73BB6" modified="2012-11-28" version="1">MAPLQVKYKVQPHFGGLTPELLRPFRSSLIGWGVTAGVAVSLFMSPVPLFQKDVLQKIPFLAPYFTDNTPESDKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD34</accession>
    <name>K1VD34_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome subunit alpha type 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD34"/>
    <dbReference type="FunCoup" id="K1VD34">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VD34"/>
    <dbReference type="eggNOG" id="KOG0176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="InParanoid" id="K1VD34"/>
    <dbReference type="OMA" id="NHYFTYN"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="185" mass="20330" checksum="A5A021AA3EF2B2AD" modified="2012-11-28" version="1">MFLTRSEYDRGVNTFSPELGSTTVGITTPYGVVLGVEKRVQSPLLESSSIEKIMEIDRHIGCAMSGLTADARTMVDHARVTSQMHQFTYDEEIGVESCTQYHTDPSGTFVRYEAKAIGSGSDAAQQSLQDSYHKEAYSLALKVLKQVMEEKLDETNVQLAQVTGEKGFEILGVEPLRTAIESITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD67</accession>
    <name>K1VD67_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD67"/>
    <dbReference type="HOGENOM" id="CLU_669371_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD67"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="411" mass="44665" checksum="8B3BA19D5EA35A3E" modified="2012-11-28" version="1">MTSTPPSDASAGKKRLSSNSPPPAKTAKRIRTRTERWERACLPSPKGSTSSPEDTGPPNHRWDEDDFMDMDDHQDLCAAVWGLMEGTDANPIPPPSESTQSTPQHTGAKSTSEDSQPASSSWTDYEWIPFEECNRHLCEKAENVHAPAPNVPPAEPNTDTYQPAGLTENSSPSSFSIIVTPDFGHVSFPHSPEQLAPASLPPKPVTKQTCCEDNSPPYEQLPPRSLCIKTTGFEEDSPQYELPPPSSLFILTNAPKVGSHQRIPPLLHPLSSSMSAFNKDNSSNPNVNSNTSTHADGDPQGQRTEVHATLLQTRATFASSLHVLDPDAELKKFEENYEPPMGTEAEAEMHRMHAEISFMWSVIRKGRHKGLKKEEQVPDTSKAPNDVAGDATISDGPGQKIAKVLGGSVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDE2</accession>
    <name>K1VDE2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDE2"/>
    <dbReference type="STRING" id="1220162.K1VDE2"/>
    <dbReference type="eggNOG" id="KOG1547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391905_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDE2"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="351"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="704" mass="74230" checksum="80BA78DA2DA75802" modified="2012-11-28" version="1">MPISLRRRTRRPSPEPAPAPSLGALSLPDLTAPLVDTDHWPPPVPPVPSGHVRGGSGGGGGERGMPGMVGLGISATGRRDSGSASLSTSVPKDARLNGQQSSFGKPGVGSPWGAKRWTQSATSMHGRSGSGDRGDRGDRSGGGHSRHGSGSTVTGGHGHQRQGSSSSGYREHRECGGAGYGPAVYGTCGGAGGGCGVPPVPPLPGVVPESVASCSARDSQSTINLSGIPGMGESTTTLPFGDSTLSPYSAYGYGAYGGSQTFPRSPTLGSSTYPSAESLSLLSKSRASQQQQQQQQNLPSSPRGRAPSLVKDANGASPEFHRPFAQSVVSPPKIPTALPGTVSARKRAQKRVAALTIMVAGPTGSGKTSFIEALTSVLDPNRRRLAVRMGPTTSVVRHEVVGTSDRVRRHFVILDTPGLPSNDMVTTPIRGKALNALIAILEERQARLLDEETKVVRRKSDGGELVHLVIYVIDARTILTPLAKVDIDWDTVQEPPPCGPSTRPESELLEADPTGVDARLHLDDIEAIRRFSARANVLPILTHVDALTTGELFAVRLAVKRDLATVFGKDPLGGWGVLTAGQDFEPFEPGSETPPPFSSELASVSEDADADADDGSSTEGEETEGGRLELPYGVFSPEPGLGFNRKFRWGKANASNYKHSDLPHVRDGIIQATEWLRTSTREVVYERFRTERLLNAKGVKSLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDF4</accession>
    <name>K1VDF4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDF4"/>
    <dbReference type="STRING" id="1220162.K1VDF4"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109501_2_0_1"/>
    <dbReference type="InParanoid" id="K1VDF4"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="178" mass="19752" checksum="2CC83BCF021F8A07" modified="2012-11-28" version="1">MSAFHSARPAVRRTATVAQTRAASSAHPVPPVPWASKTHTKKAPKIPNPLPAIFPQKVVLSDGSTFMQWTTAPTPQINRLTRDITNNPLWFPGMEATSRDGIMEGRIGKFHRRFAANNADPEKDSKVEDGDSPAEGRAKEKQSFQDSDLAWMSEGAKAEKISTKMKQRLSMKQKRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDF7</accession>
    <name>K1VDF7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDF7"/>
    <dbReference type="STRING" id="1220162.K1VDF7"/>
    <dbReference type="eggNOG" id="ENOG502RXPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518939_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDF7"/>
    <dbReference type="OMA" id="APAYHEC"/>
    <dbReference type="OrthoDB" id="2562743at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="525" mass="58120" checksum="95EB91F84077487F" modified="2012-11-28" version="1">MRVRVTRVGLAFCLISSSDTRRRRSLPAHTSSELDDSEYTPHTPYALVVVRSPTLAVLSASVHCTAAGSSPTRNRNPEPGTAFGAPSAAFTTTSCVTMECVRRSLLGSTASVSGILHPQHCLHTSNPSSMSSDPVVDSVSEELEATEYAPPTYEAMKKHLSTTKVELSREEGKLKKLEFKDWEDIKNRTTKRLFVKVKHMGSHKEKLDAMEEKEEREYVEAFGKEQDSRAKISELQSQIKDLEQQLKALEPYVAQNQRLQRQLAALYKRVFDGPTPQYPQEDAAENKYHAAEKRQRELLEHQTNLRRANQLVQRATMLITSAQRSAREAQSASQWDMWGGGRMADYMERSALGQAQNCIDQARMTWEQARQYVPELAPFPQTTMPMGNLFGDVFFDNIWSDMAFHQKIMDASRRLDAVAAAIADGARRVNARTGEAEQLAKGAGRELDAARKQLDGVRREIFERAANPAPQYSAAPPQPQTIDFAPPSGPPPQGGGFAPPDGPPPPGGPGAAQRTPSAPPPEYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDH8</accession>
    <name>K1VDH8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_06669</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDH8"/>
    <dbReference type="STRING" id="1220162.K1VDH8"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009442_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDH8"/>
    <dbReference type="OMA" id="WIFREYA"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="419"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="376"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKC98915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="913" mass="101232" checksum="6D9D45DA83FC84D0" modified="2012-11-28" version="1">MPRVDAPVTAQQAAAAYTPPYQAVFTPYATPSIYGSPTAARDFASYRYAYLLWCIIGLIAILYAVSHHLRLSGGSLGAAYNKWGMRRHTMFRQSTLPSNSTMLVAFIVAASAIVLCIAGNDYITPLSAVWDFRSSKRDIIPGAPIGNIAKSFWTSGSRFGYMAFALFPLVVLLALKSAPFAIFSIRPFTHLHADKLMPFHRMAGYFVWLITTVHVVLWTVQLFQDSYKGQPVWVAAWTNYHFIFGVVAYALMTAMVVMSVRPVRKTKFEVFYASHTLLGVALLITSILHHTVIWWWCAIALGLWAGDRITRWIRYLRINSGASSKADPRGGQAYQGVATDNIALEEFHDKMVKDPFETNYDHSAQPEIRPVGAYESRYHDATPPPGSPSYDQLSNPYDSPRSVSSPRVPPKDSDEQTLTSYHQNRVSDITPESPPIEPGFAQAQLLPSRTVRLTIRTPHKIRWSPGQYVFLTLPELSGIQSHPFTIANNDPNEIVLLIKARRGITRRLYNLVKDRSESSLRSADKRQSIVPKANPVYIRTKLEGPHGSSGRVRWGEFSTVLIICGGSGVSYGLSIVDHIARSMANFEQDHETRRVRFVWVAREYAELAWAASALCRARRLLGPEQLQIDIYVTNANLTGQDKLYDDFSLQVPKAPFAGLQRNASSESLASQLSTDPRSEFDHIDAEMEATDANIRDLTQFDSEDDVHDHAQNDFSRHIQKEGKLRRAKTRRAMKARESIGGGYNGFAVHHGEHAGYDQGYDMSQMRAAPPGGAGGDDDLGLYPPQPLASPIRANSPYGSPSAPAKACMRQDARVLYTLGPEFSPAGGTLWIDEADYAATSILSESARGGRPKLAALLEEELDKAQGAMVVTTCGPSKLNTVVSNLVSRAIKPGRIRQGDRRGHVVFYSEDFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDK0</accession>
    <name>K1VDK0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDK0"/>
    <dbReference type="STRING" id="1220162.K1VDK0"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918853_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDK0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="303" mass="34275" checksum="D5C9BF32E0CC2826" modified="2012-11-28" version="1">MCDTRRQAEYGSYLPFPGADEQPQHGLSAARSSRNGMHVTFSDCEEGKRRRRCSKSGSWKADDQLKWGKRSAKSAGLAIEEVLSRWSNGELLMFKLWQLTRVPRESVTQATGQEITECFEILRSILQAQPTSTTQPYDGDLGVNLRGKLLRSLIRAAANMGADRFAVDLFFERVDMQLRRPNQRIISLKQIATDITHNRWWLLGARLLDPERIPEQLLSPEVITVAMNCTLIARRPWDTKKLFAMMHPDEAGPDSICYYLQALLQLGDRDGAHRVMQVAMERGVDPEKVQVAMVKGGGRGEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE17</accession>
    <name>K1VE17_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE17"/>
    <dbReference type="STRING" id="1220162.K1VE17"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345519_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE17"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="309"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="834" mass="89277" checksum="3ADFBD9756C80622" modified="2012-11-28" version="1">MSYTEPAAPPLPKRPSMRRHSRGSANDAASLATLSSSSPMPGIPRRSSAAADSKPLFATTPRHGSASPTPKHEFPTTSHLGLSLNAAAPSSQSQTGDSPESTTSTLVPSTPEESSPPPLSVSRRLSARGDHSPPKLSLLQRQRSDPRRSRPLSAGDLPSPPEPTSAVSPGYEIRTIRKKSGEIVKPSLKTRSMSTPDLGRGARTPGEDGDSPTRSSHDLHTKSVRFNDLGGLESVVHFLRGQKVTALSRSPDDPPTETDTDNDTDLSDFVHFRTRRSLAKSQAEESREVQVAASSSVPRLRVDFGPGTQGILKDEYVILERYDLQNAPLAMRGTVLVRNVAFQKCVTVRFTLDHWQTVSEVSAQHVSHVPAATTGDEGWDRFGFTIKLDDYKRKIEERALLLCIRYNTEGGREWWDSNNGDNYRFTFKRAAARRPAARSTRPHSFHAHSHSDAFGLPTLRLGRQSAMNSRDVRSWTFPRTGSQTAHSSQPETNAKTHQSNDAKDKDPSPPQSPPPRAAFEPPVRPDVHSHLRLKTYCAPSPPPSPPKSTMAALPLAPVRGRAGGAGNSPPMTLVHGRPANSWPPAIPANATKRDAATSPPRDKAGSPLPSTPPCTGAAPLFDSPTQTSSSGSGSEDEKKNSNGPRKSRSNGNLQALAMDDPATDAAGLITPPSSNLSSPPTPSAMLPVPLTPSATASVGSTNDSSPLLTVPPSDDEDHGPGLPADSRRILNAATYQEFIDKFCFFESPPTVSAPLAEPTAYRPVWPKSGLSSPSNGYVGRHALSHAHSPRATTPTQKTYASEADYFSERSATPTLSTGFVTPRSSPPTQASMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEC2</accession>
    <name>K1VEC2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000374">
        <property type="protein sequence ID" value="EKC99195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEC2"/>
    <dbReference type="eggNOG" id="ENOG502SF3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240005_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEC2"/>
    <dbReference type="OMA" id="RINYATE"/>
    <dbReference type="OrthoDB" id="2565251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1143"/>
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    </feature>
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        <location>
            <begin position="1246"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
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        </location>
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            <begin position="503"/>
            <end position="514"/>
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            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
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        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
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        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
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        <location>
            <begin position="1270"/>
            <end position="1281"/>
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    </feature>
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        <location>
            <begin position="1299"/>
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            <begin position="1340"/>
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            <begin position="1361"/>
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            <begin position="1520"/>
            <end position="1531"/>
        </location>
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        <location>
            <begin position="1533"/>
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    </feature>
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            <begin position="1554"/>
            <end position="1566"/>
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    </feature>
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        <location>
            <begin position="1582"/>
            <end position="1594"/>
        </location>
    </feature>
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        <location>
            <begin position="1615"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1668"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1723"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1734" mass="188999" checksum="64E35EE19A01A073" modified="2012-11-28" version="1">MSARQASQSSSTSSVAAPTAPTTRSSTRSRRDLRPRRSPPPSAVQNSETTGTPSSPKDAGPSQPMPSAMSLQSRRGGLSPTVASTTSASSVGGRLREDPLLDLLIEQQKKSLREVNPLEGGSSDEVEQAARLFLETSRLCFQTSMDAMELDEAEMESDYRSQERDNVMSTWTDMLLAGRVFFDCNQYEVASAEEVKEDVRRRNNVLTDTAAFFLDKAVALFNAIVLVKNINLPDSVATDLEELGAGTASARVTARNRVLKNLWTNFWHIVPGASNEEMDLWVQFTVQSHRVLDDERVKDNALPKPAQGGFWGKNVFADYSNLDHGSPEYRTLSNLKPPLWETFEDSVLEYIRKKSSELLDFQVEEGEGPADPGEANKDAEGGEGSPQDGAEDASMVEPLDMDMFLELAQEIEAEKGISSPFVRSPQRPTLTPLIRLGPERPTPSFDWNARQKDAVQISWETQEQESERQRSASQHSSDADYYELPGETQLQGAEGAMDVEPEASQHEDESRRDSDEELPTMTQLQGGSLAPFDPSSPAGDAEDHEVDLPPESLLKGESDAFAEGEAVSGSSETGDIDNDDFPTETQLHGYAGAFTEPLDAQATILEEDEEEDDMPSETQLNGHSNALAPIQPLEPLEEGEEEERSALPETDDFPEPDQFEGDDAAFATQAAGNGQADQSQSDVEGRDRGDLPESDVAEEQSSDGTQSGLPDMDELAGDYAALNVSEPEEAVEAVDEEDELPESDPAMGSSQGVSEPDPAGDDGRAPAPSDIEREGGEAEAPVGVAGDPADDVDGDELPSADQLQGQDGFLSDDNELAVAHHLAAEALAQASREEQPPSASAPTEHVAQRNSQLDAQGTPAVQEETQSVDVSTADALPQNELAEPNTTPAVHGLPEVIESAVAVDILHAEAAIAALSDAAEPPLTEPKISAAETRQALNPSAAGPGPRHSLPARFLHPRRPDLTEFATPDPEDGPVEDRPSTSNAAARHLHGPRRLHRLRTDSPTQRSHRYSPPMLLPFVPHHAETSPAIPKTPSQAQTQEPGSSVLGSGVIRTTSTLRMIDSQTPLGGVRRQIVTHVRSEGAASIGPRRARSNTGRLGYVAPRNDPYLHDEDGGPLEPDPEYVTPDVYPTPPQERAERRTRVPMHRKARRWTEGEALLLYRTIQKAWWSERTAQQVAWYLHGEWGQMSQRLKAFSVQNMKDKMREIVKTRVRNDRAVVGRARHWLPAGHPDREAYEEEMAAWADAENERLQQEQEEAEEEEERKALEAAQADEEEMEDEVAAADLGGSAEELPDEEMDWEAHPELLVDVEGQEHASELSEHEDGRGGPAVREAAHVTREPSAQRTTRAARTSIGARWRTDNDDEIDELESDQGEPEPADDFADNISVADSDVGIAEHADFPAPIDVAALLNSRKRRTTEPQSGTPKRRHTFGAEPRGLVVRPQARPSLPAPKRKTITYRNQPRPPRELESSETDSSEEEARLQLPALRTRPSSGTPRSGPATAVQQARRSAHTEPRPPRRSTSAARDAAARGVQSSPPQALRNQHGPRQSSSHLESESSDHDDFVPKRWFKLPEITSKRSTRASTASQRLSAAAESSCDDENTQNATLERHQADADTSSDGLPDETQASLGDTQPEKQVPRTTVVARARRGRGGMKGGPSRPLSVVAERTESVESRIDRLAPARSESASSGVIPEAETEEEAAAEEEEEVAAPETPRPSQTSRLREIARKVMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEK8</accession>
    <name>K1VEK8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEK8"/>
    <dbReference type="STRING" id="1220162.K1VEK8"/>
    <dbReference type="eggNOG" id="KOG2186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047442_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEK8"/>
    <dbReference type="OMA" id="ASAPGIH"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="292" mass="30346" checksum="B8B99842E2EA4DA4" modified="2012-11-28" version="1">MVSFQSLSSTSIGNAAGPPSAASGQDYKSHTSCISEAEKYQGALYKGPKKAGGHQGNNNKSATQTPAASTPADSPAPSESGASGIHPSRLNQMGRPEHDRGQFGGRGRGGFGGRGGRGGFRGGFQNSQGSWSATGENKLRPEGGMRQWGSAPSSDVEATSTAPGTPNVATPTTGGGDEEPTKKKRKGDKGGTGSKANSRVGSEAVDEGSSKKRKREEGDAILATENAAPPSEKTVKRIKKHMKKLEDKVTETMSLADWLKRVAEGKEKTLDNSDVLQGVQVSLVNGHWQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEQ6</accession>
    <name>K1VEQ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEQ6"/>
    <dbReference type="STRING" id="1220162.K1VEQ6"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391906_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEQ6"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="49"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="704" mass="75428" checksum="8F0A3E6894530DCF" modified="2012-11-28" version="1">MDVQDRTSTARDSALADMSGPGQVNPNGPGRNAAADALDRPGVPDGLFRILLVVAGAAAGNSILELIAALSKDPTMDVQLVANREGLRHVSQADVDARLAECPSSGPRGVKRIWTDNDDDSEETPLPSRLVQWADMLLLAPCSASLLASLSVGACDTLPLRLLRSIAPNKPVLIYPSMPADMFSNAWTRRHLEAAKQAGYVVVGPQCRDDNRGRMTDWQDIVISVQDMATFFNMRQQQAHLAKLAEQEQAESTMEGTETGSGPSSTQATRESSPGGTRKRSREGPTMPTVFQTFAPLWHESSPEHLDRGFVPGQMHWQGLPPIATGRTTGLGRSEIDLTMPSWETAKRDAEKERQSDASTPSLYPIIPIKDKCIHSRQRVTSDSPADTACEAYQQSSASAIRGAVARDGAAPPAVSSTAPMTRRPVGTTALFILATIGAPVHKDWDMISVKLQPEAAQYGQEVEQLNVLARGGETIVQVGVLGICYQFNPWIAKNCTDPGLGYPFPDLPGLIIDQPDRYRALTVALVLNPLAAGLAATAATIWVFALASNLRVLAVVALIPIVLAKFAAVTAFGVNLAIVLVCISSSPRSPLPLLICHTLPLPSPATPSRPAPRLPTELTPGPPLAYLGRLPRRSVGSHRPPVLVLRRRMLHGHARIPVRGAGHAWREEEVQQAQGPQYLLATSPAAAKSAAEDPVAVFPLVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEV9</accession>
    <name>K1VEV9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Diphtheria toxin resistance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_08119</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEV9"/>
    <dbReference type="FunCoup" id="K1VEV9">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEV9"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015210_1_0_1"/>
    <dbReference type="InParanoid" id="K1VEV9"/>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000005">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="582" mass="62623" checksum="7D635E571AEE99FA" modified="2012-11-28" version="1">MSADAFFAPATHALEAEVEVEGGAMAPDTLSLEEAFDVETTAKLILDGGYKVIGLQFPDELLPSSVAVYRALMRRIQSAGAQAYVLADSTYGACCPDVLSCLHLPADLLVHYGHACLTPTDALPVHYVFPRAELDPTTAAQELVELARKEGDLGDSAGVIWDVSYDWKDDEIEKAFHAVLPETKLEFSRINRPCLVNARKELPTGLPRTGGCCATDKSTEGCCSSEKTAGGCCSTEQPVGGCCSADQPANGCCSAPAADEAETEAQCEEEASGSVTSGAVPAAAPLAKAQSTSAPALRRVPAGSVLFYLGPDSRSLMNLQMEHSSTPIFAYDTDSGARAITGASRQLSRRLYAVHQAMASDVFGLVVGNIGLKSSQPLVQMLRDELRAHQKKSYTLSVGRLNPAKLANFAEIDCFILIGCSEGGVVDNPKDFLKPIVTPHEAMLALRGADWDPSKWTLDIDSVLQEAKEGRDADAGDAEADGESREKDLDFDLISGTYRVKRTFVEKEDDLVQGTQDLTLRNQQWSLANLESSAGSLFLQNRSFQGLEPRYGQDEPSTLEQGRSGIARGYTEEKDERHREIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF06</accession>
    <name>K1VF06_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF06"/>
    <dbReference type="STRING" id="1220162.K1VF06"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_524962_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF06"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="519" mass="55920" checksum="D550820C18033874" modified="2012-11-28" version="1">MAQRASEVLAELDTLYPPSAPWRIMGQVLSDTEQAYETSEWKRVRRAMHTFVNIRATHRMAAFKAYDVGAKVQARVDAYPKTRAFKTTAFTPAEVKYTIPLYLEPQAEMGPITLRNPTNEPEKRIVSYVKYLLRSAGILYHHVPDTHPAILQLVLPLAPEEPKEPKTWVSSLFRRPSPVRSSSVPPPTVNSVKKEQARQKGKKEEWHQQVWLRIEVKRGRSRSRHGSRAASASGSRAPSRVHSRAPSRAPSAGGSRTASQAPSRTASRAPSQAGASRSGSRAPSDGNGSRTPSLSGADRQDRLDRRVTLDLGPLHGALMHASGLGAGVAGAGAPTTSGRRRASSSGSSRVVLTLTEPRGYPLLHSALSAAKPPSEAELARQVEERSSVSSTASTSTDTTETTGSSALEIPRSGSDDSHDSREDERGRPRSKESHERASSSTTPRRLSKLSKSPHQHRSVAVGSVGSGSTAIVGSASTVGPDEREPSSLLEGVFGRETAERMLDGGMRSRSVPPGKLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFA5</accession>
    <name>K1VFA5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFA5"/>
    <dbReference type="FunCoup" id="K1VFA5">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFA5"/>
    <dbReference type="eggNOG" id="KOG2912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027534_0_1_1"/>
    <dbReference type="InParanoid" id="K1VFA5"/>
    <dbReference type="OMA" id="TAGENTW"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59750" checksum="05025E4FF7580927" modified="2012-11-28" version="1">MHERNPYRVRKPDFAALAEKDEALRPFVTKSDHGASIDFTDARALRALTAALLRHDFNLDIELRDDRLCPTVANRLDYVLTCLDLAQYAAPGPLRALDIGTGHVAVYALLLHKLRPEAYVVGSELEPTSLAHAREQAARNSIAPAAVEIKGVPPDNSLLGHLKDQDSWSFTMCNPPFFASLAEAEEARLAKATPASAAPTCAPNEQVTRGGEELFVGQMIDESVAYGDKVGWFTSLVGRYASLGPLVKHVLTKTTNYAVISLRQGNTARWVLAWSFSPYRLPDVSCTDPVKVADEQNLTRPAHVEKGTSFAKMVSLRNSFVHDEEEKDLDEVRQTITDVLKSVNIDTTADEEGVIHLAPTTNTWSRQARRAAQRAAQDAEGGEEASAALPESSTSQEPLFRARLSFTKPEAPASTDADRESDVEAPSPSVPKARAAMEWQWGRDRTIVDAFWKFVIQKAGLRKRKQVGEDGPAEKKSRLGVDDEEQQTNNPYLQHQDNPYLSHGQSGGNRGRGRGRGGRRGALGGGRGRGGYSRPQDQGWARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGD4</accession>
    <name>K1VGD4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGD4"/>
    <dbReference type="FunCoup" id="K1VGD4">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGD4"/>
    <dbReference type="eggNOG" id="KOG1529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_3_0_1"/>
    <dbReference type="InParanoid" id="K1VGD4"/>
    <dbReference type="OMA" id="NNNWFAS"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="155"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="298" mass="32690" checksum="5BF99CD188D573F0" modified="2012-11-28" version="1">MPNNPRNADQEYLQGPRIPGALRFNLDKVAEHDPAKNPLGLTHMLPSAETFREAVETLGITPDTHVVVYDTVGVFSAPRGVFTFKALGHDKVSALNGGLPRWIEEGYDVDEEELSKDPVAAKRSSYPVPKRHDDYVRSYEQMVDNSTADPALADVVLDARAIPRYAGEAPEPRPGLPSGHIPNSLPLPFNDLLTEPSETEPYTRYRSPQELSQIIIDGVGGKTVWDEIALDGRGLVFSCGSGMTACVGWLAARAVAEGENQMLAHEAVYDESWSGYAQRKESKIEKGHGNKDAVRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGD9</accession>
    <name>K1VGD9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VGD9">
        <property type="interactions" value="292"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001872_1_1_1"/>
    <dbReference type="InParanoid" id="K1VGD9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MAP3K epsilon protein kinase 1"/>
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        <property type="entry name" value="Probable serine/threonine-protein kinase DDB_G0284251"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0283821-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
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    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="Protein kinase" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="279"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="488"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1233"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="530"/>
            <end position="539"/>
        </location>
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            <begin position="1129"/>
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    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022679"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025754"/>
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    <evidence type="ECO:0000256" key="7">
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1321" mass="145111" checksum="373F6D1390DFE714" modified="2012-11-28" version="1">MSATALSNYQLGDLLGRGASGNVYRALNFLNGETVAIKSISLSTLPASSLPDIMSEIDLLKNLNHPNIVKYKGFARDKESLFIILEYCENGSLQTILKKFGKFPESLVAVYVRQVLQGLVYLHEQGVIHRDIKGANILTNKDGSVKLADFGVSSKAPTPDLAAVSDPDADNEVVGSPYWMAPEVIEQSGASTASDVWSVGCVIVELLEGKPPYGDLAPMQALWRIVQDESMRIPEGASPCFQKDPNLRVSAKNLLRHPWMQSAKKNLENDTVDVGTLKKGPAAREKVTSNGTKAPDVAPAASKDGHTVKSKKPITEYSAAIQKVQEWNEALNAAPKNFGTVRRIPNPTKKQHEPPLPPPSSSKAANPPVAAPIATGGLLQKNKHVSDVLKRAKESAEAEKWDDDFAFDETSSKISSFRSDRSENAADDANANHATVRQTKDPKDSQRDPHSAPKSNKGSARLKGIPEDYSDLAGDEDNLDLELKFSNLKKMGSFESEPKDKVKSSKDTGKEKEKERERAKPEPKREEPLAPKPEQPVRPPKAASRPLPKKSSSPEPQRPTTSPTLSPPGSRQSSLRGKAAEAANVELQKYTEDDDDDYNDIFDGPVIHPDGVALQSLQLTRRSNHSWREVEEEQDPFAEFDDDFATNSLEDNLLQTKRAALHTSVSDIIARLEAGGAPVREAADELLTLFETSPDDMGLEHYFVVNHGMLTKKHLLETRLEASKFIQHLTHSPLTLQMFISCRGLKVLVELLDEDYTVNKHLILSSLEGIGSVFDLQPDFCRMFTREGILDPLSTALLALIKDAEVGEETTKRAVDVLLLFCQVGQADVHVRAAFAHRTIMMRLLKSLTLLPRKQLVTAIKAIKHLATSPQLIEVLQNSNAMEVLVELLGETLKGSFSNEICSHIFQTIYSMCRLSKSRLEEASAAGLIPILKRTIDDSSPLKQFALPVLCDMANAGKVSRRLLWQNQGMQMYLTLLDDPYWRVSALESILAWMQDEPARVEEVLLGAAETESFIKCFCLAHGASFARILEPLLKLLRLSQHFTAALGKPRFFKKLSEALSRDYEAVVKSNLLRMLRAVIEQRRDRVTLVREFSLDAIVEKLAEEHNPVVVRDLARQIYPIVTGQAAAEPRETRERDPRDSLPRRAVSSRHHAGLSERFGSITERLSTASGRYESRGGLGVAEGLMQGLERAQAASAAQAHAAAHAALTGRSRPLSQQLPTLSPPIQHIQHIRRGSAGAVSSPLAPSMSRTGSGTSTLGPRRTSNGDAGMRKVSPPSASSAPKRRSHLMDVQWDVDENGKLAKSVKSPIRPKSQPGSPILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH49</accession>
    <name>K1VH49_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH49"/>
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        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH49"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="InParanoid" id="K1VH49"/>
    <dbReference type="OMA" id="PANINGH"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="172"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="692"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="785"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="946" mass="100912" checksum="6A438D6FB0CD5D41" modified="2012-11-28" version="1">MDANNAPVTPNITLSDAGGHAQSLPGFVAPTSTYAQAPQLSPQPQPPLPASQPDLSLSPAHPSGQMATPSASAPTPTAQVATSTGLLPALSPEAARLGQSQPQAAQGQMPTFAQQMPMMHPGGQPRPGQQGFVGSPHGTPGGSQNNVFQAVMGAGPGQVPQDDVGGAGNVKVYASAYSQIPVFEAMIRNISVMRRMADSWVNATQILKVAGISKSVRTKILEKQVQTQMHEKVQGGYGKYQGTWIPLDRGRALAEQYGVLQFLAPIFDFVPPPTGPPALPMRGGSATPNAKTPGGGAGARMPGSAGSAGRLMSPYARQNAAGPPPPPPQFMQQQQPMPGQQDMMMGQPQMLYQQQNQPMQGMYYQPVGHPQPPQHMVYEQGRDPNMDMSGGMQMQPNQGGLAPPANINGHGNGMQGLPQPNEMYVDQYGQAHSVGMPSAAPISAEVDAPPPAKRARVDEPANGEEPQEGTGSEDDDDETRDRPPLPASFRLSTKPFKPRLSSESHRRRQQLLSLFQTDTVDIRSVFELGPNDKPDWDIDMVIDEQGHTALHWACALAKMDVISQLIELGADIHRGNYSGETPLIRSVLTTNHAEAGTFSQLLEKHLGESVRTLDHSYDSVIHHIALSAGLKGRAACARGYMAAVLGYIAQEQTKTRELAQSTPGNGNALAPAAAIGTDTISLKRLVDLQDLKGDTALNIAARIGSKPLVNLLLDAGADKTKANKLGLRPYDFGVEVAALQVSNNEAVVAALRPEVKRPEKRNISALFEDVNRTFDGEMEKHVESLNSVEKNVRVATRSLAEKRQQVDAARQKLDTLEQQAARIDNAKRALEANMDWSGRTPLKGESSLPPAFGLVPPLAPAAGEPSSATPATDPPIPAVGEAGALTQLRRLAMWEDRMAKLLEERAAELEGDGADRAVKYRKVIALCAKVPVEQVDDLRVSEPGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHW4</accession>
    <name>K1VHW4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHW4"/>
    <dbReference type="HOGENOM" id="CLU_1267690_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHW4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851879" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="20201" checksum="C67A6650BFDC5F56" modified="2012-11-28" version="1">MSVSCTATDPALLAACCVVAGGTLFGSSCAVNAAWAFQACAGDSICDGVLVKRQETTDAGTATSAPTEPTGTETTSISEPSETSSASPSVSGSESGSAVTSETSVSGSESGSAMTSETSVSGSESAITSPTTSAEASPSAGTQSGGNASPSVSGMSGTESVSPTHTGGTGAGSGTGHGSATSGASASPSVSAPTGAGTKKRASAAALVLGVAVAALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI32</accession>
    <name>K1VI32_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI32"/>
    <dbReference type="STRING" id="1220162.K1VI32"/>
    <dbReference type="eggNOG" id="KOG1039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408261_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI32"/>
    <dbReference type="OMA" id="NSCTAGK"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="616" mass="63446" checksum="45267B2B8DD7E495" modified="2012-11-28" version="1">MSAPGPSPIPKPIPGAQARTAANIAGSPAGRGAASPAGASYRRPSTNGYSVGADDNNWRSRDNKEGTSVPKGRGPERTVGGFEKHEVRAAGGGTSALSTSKGKGEVKSLSHVPCRFFKAGACTAGSSCPFSHEVGGKKEVCQWFLKGECKFGHKCALAHIRPGEPMSMDRRNKKEQQREAREKADRDRGEGGTSYKEARSLGDDLGTSPVASTSARSAAVPTSNSNPVPIRSAISASLQSGSAQSPGRLASSPLREPYGPPAAVVAGSPSAGFNQARSISGVAGFASSPSRPSPLSTSFNARGTTFVAGSLKASAAIAHSPLRPPPPSGAFSSSFSHSNLGGDKPGTPLSASFAGGRSIWTRSETPDEPLSPRRRPVLPPTTTVVDDEGVFEADDDHGEDLLPSSLSDLLTPTERARRMSRHDSRDGAIVGSPSRAPFANPHQYVGAERLAQSAGAAIHSGGFLQALWSQDGKDARTTGGEAKPSTSSGSSSQNEAAGQQGSQRASLLSQQRSPDKRSSANISPAVDAPYLVRDLVTDPNSPSARALQEHAPGQSLPGGLAAALSRMHMQPRATSGLATPGSKADSSATTPPGYNAQLSGARRDDADDEGLFHMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJB9</accession>
    <name>K1VJB9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJB9"/>
    <dbReference type="FunCoup" id="K1VJB9">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJB9"/>
    <dbReference type="eggNOG" id="KOG2115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003094_2_0_1"/>
    <dbReference type="InParanoid" id="K1VJB9"/>
    <dbReference type="OMA" id="QKQAVML"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="671"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="927"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="947"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="980" mass="106850" checksum="B69EFC68963C6F64" modified="2012-11-28" version="1">MSKSASGSASGRQGHDPTPPPIVTTPAPSSPPASESFLSEFDGTAGSVIDTSYDAGWDTPTDAASLNIVSWKLGVNARVEDGIEKRGFNAISAVLAHPTKKANPLRASRKPLPPVAQPPPLLPKPYAPSYYDGYLKSIAPLYEQFVQSQAAATASAGDIDLQQRKSADDLPSLDNIPATFFDTNFDLANPTTWNDLMSSVPESGKNQDDELQDVLSTHLDNLERHLVHEITLRSSSFFSALSNLQDLNAESTSCLTRIADLKSSLKDVGSKQARKGLEIIDAQARLKDLRTTESGVKRMAELDEILRVARGLADGGDWSGSLDCVEDVVRWWERNDKDGKDGVEEKALALNTLPALANLPTSIAVLTTNIASQLESVLSSVLQSLLSESDHGKPFDPLEVRTRIGAMLSGLMRCGKGDSLVSIWRNAVTTAIREGLRQDDEDVDKATEVRGQTLAQSLQSMDHAQFLELCKKMYGSMLTRLHLVQKIGEEMAAMMSENQHIKALIISVGSDAPLLARSPDLPPFEPADVLSSACELANTRASKILSVRNEQHSSLPIEQFVEVFNESWQFVVATEVLAKRMIVSLRGVAASQARAFLVSYHAQKLTRSAKLVEEETWVQIDVPPSTQHAVDLMVEAAVKDPTECLIPFKTSNGSNGDQQQGATKLINIEGKSFFVVTATSESLSLLSDYLAVVINLELVVTDVMSRIIEFLKSFNSRTCQVVLGAGAMRSAGVKNITAKHLALASQSLSVVIALIPYIREFIRRHLNPKQAVMLTEFDKLKGDYQEHQNEIHAKLVAIMADRLAVHVSELREIDWEATPAKEGPHQYAQMLVKETATLHKVLSKYLASNTVVAVMSQVLAASVHRLTEEYAKIELKSEDAKKRMLQDAILIVQRLTPLSELPETLESLETLVKEKPTPKKNVAANLGGLFKRHQKESPTSPAAPTTELKEEEKAKSPLPPEKTRTPVESKGADAGDEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJF5</accession>
    <name>K1VJF5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJF5"/>
    <dbReference type="HOGENOM" id="CLU_1416097_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJF5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852165" evidence="2">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="192" mass="19369" checksum="1E6CA86213D04CA1" modified="2012-11-28" version="1">MRLASAFVPLGALAATALGAAVPSSEAANPGGHFECTEEGPNGACLRWTTSSASAITFDELNKTVIVPAGTQLSAAEGATFESVSLLPGAVVWDGLVQQRVVVSLAARGWGKGRGRLPVRGAGVPVLGPMGTGARGRILGMEVMEGKISRMARTARPRDASSGSTAAARRSQIGSAGTVANVSAERWSGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJT6</accession>
    <name>K1VJT6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 13 protein/putative endo-1,3-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJT6"/>
    <dbReference type="STRING" id="1220162.K1VJT6"/>
    <dbReference type="HOGENOM" id="CLU_1732781_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJT6"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851905" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="151" mass="16987" checksum="F2C8E8DEA9DD0A8E" modified="2012-11-28" version="1">MRLLLTLISTLFLLLGAHAVRFQWPSGPENGGYLGVPHGGCCTNAQNGTQVYAAWRIEGEHIRMAGHGELCLDAGWDAGYGTTLKIWKCFDNHAPQRFKYENERIIHIPTGFCIDVQDGNRQNLQLWECFDGNTNQRWRAIWPPTQSAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKW8</accession>
    <name>K1VKW8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKW8"/>
    <dbReference type="STRING" id="1220162.K1VKW8"/>
    <dbReference type="eggNOG" id="ENOG502QW1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263601_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKW8"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="3">
        <location>
            <begin position="554"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="903"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1275" mass="140461" checksum="60B1E55F755AADFE" modified="2012-11-28" version="1">MLSPTLAPTSESETSPTVETTRYPHTRSTHKRETSFGGGHVTRHGSTSESEWSLPDQPRGPTRKESQSTLTPPVRVFPRPPSDGNFTPTIRPGSVKSVSLERGDDDTASRRSVRSFRATVTKHRPPMPHKASHDSLLPTMVQAIESSLGPNVITGSSSNGGGSGSGGQGRRSAPPSSTTTHARTNRDLRPDKSSQNHKARTGETADRVTALNGQSNGHDGGVGVIGSFDKRLNRSVMSLGVKAKAEKVVNADPQPRLASLYLVTGLFKDPSEWALSDKDAVLGVQPMEDSLGVFWRPNMLGNTWSGEKSDEFAGRSGSKSGRSGSTVRRDANGQALPGTKPEGASRLVARAMKYAHPKDIEVVNSTLAPPTTCHTFTFSVARQGTLSAIAAQATRASKIGAQQYDNFNPASASTPYNPVPVGQEHLRGTTSSSDLIFYGVTLTVWSHADKDRADKLNEFRQRVGVRHREDSGLSESTAIKERARRRSKLPWLKSDPSTPTDVTPSETGVDSDMETTFTSTDANASLSNLVPAFGESTDVFWLPYGLTLGELPSTTRELTAVSRYPIYDIMQDYLRLSVSLPRGVLQADIQWARYQKDARSHMRQIFTLLNAEAPRPGDLFRLPIGNSRNDEVVIEATMPGALDFDKGIFKVDFQMWPIFQCLDLDNIITCVEVALSNSGRVIVTSRHPPMLGTAVQTLKYIVELRGWNGIALPHIHTRDSTFIIEDPGPYIIGLPTEARYMLTPPPEVVIVDLDTNTVSCKAFPAGVVTPREKRMKARAKLLASFGPSYPSEKSVPFEYRVSFPKGAFRNINRVNHGPIRPRYLGERLHPPDWWNQNAVISVFDKIMADKKPTLFQRLTKSGFLRAQEQLSANDMLAKAMMRKRALQEGEHWKQRFETFEKYAERLAIEASELKLRIDKEQREARRLSNTVGHAPIDLERERNAIMDAIEMQITNALEHMPITADLRRLLPPTPEPADAPTTPTDSPPGTPLSNYSVPLAPKKPRRPGARDSTQTTFSWDSQTSNNPVSVLGALIDGSIRREHLGSIVDTDEVSNADRFLSTNKNDSISQRVAIIQAKSEVQSSQAGSHDGHGSYDGHGSSVDSHYYESEDSHDYRGKPSSPSSPVSDYTTRAGSVRSSKSYRSSRSTPRRTRKLAIRSPSTAESDHEITPVEEEPLDQEEVYKLRPTIAYRPLVLRPPPRKVTQKKSYESIDSASTSYEQKRRTREVLVTPPEPEMVALHDRDGERKVVVDDARPSSVISTMTVTFGSPGSNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLC4</accession>
    <name>K1VLC4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000168">
        <property type="protein sequence ID" value="EKD04990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLC4"/>
    <dbReference type="STRING" id="1220162.K1VLC4"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_2_1"/>
    <dbReference type="InParanoid" id="K1VLC4"/>
    <dbReference type="OMA" id="HYEADIY"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="8">
        <location>
            <begin position="701"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="954" mass="104904" checksum="867CA33EAFF4F03F" modified="2012-11-28" version="1">MTTIYSPAEHEDYRPGRGGLPPRAWHKSDAQRLSLNDTWKFRLSQTAAEASDFAEQSQFDDAKWGTIPVPASWVLEGFGSPIYTNVQYPIPLDPPHVPTANPTGDYRHSFELPAAWPKDGKVWVNGKEIGTSSGSRLPVEFDVTAVVTTGVNTVAVRVTQWAASTYLEGQDMWWLPGIFRDVTLLHRPVDAVMDHFVHASYDHITGKGSLKVDCNPSGRMTIPELGIDSATGEEITVAVEPWSAESPRLYQGVLSTGANGEKIPLSVGFRTVKIEDGLMKINGKRILFRGVNRHEYHPTKGRSVDHETMVKDVALMKANNINAVRTSHYPPHPDFFAICDEYGLYVVDEVDYESHGFSCIDWRNNPTDLAVWTPALIDRTARMLERDKNHASIVMWSLGNECGVGFNIGEMATFIRQRDLSRPIHYERDWTARYVDVYSQMYTWHKEVERIGQGIDEFAPQKYADVAAFKFASPEEEAKIKARRDKMPFLIIEYGHAMGNGPAGLQEYQRLFEKYPRCQGGFIWEWIDHGFPKKTADGQEYYAYGGDFGEEVHDGNFVCDGLLFPDRTASPGLLEYKKVTEPVHIKDAGKGTVSIKNGYDFVNLSHLAFTYRVETDGKVVAEGKLEVPDVAAGEAATVQLPAAQVGAGESFWIITASLAKETLYAPAGHEVAWTQFHAAEAPKAVAAPTGVAPVLSGETITLGPATFTKLGALVKLGSLPVADSRLTIWRATTDNDRGADLEGTEGYNEAHVYANIWKAAGLDRCHTRVDKVAIEGDALVVTTRLGAANTDRGLVTVYTWTGSNEAVHVNVQIRPDGPWTGIPLPRVGLQFGFPASLSNVSWFGEGPGESYNDTRSASKENGLRLDVRHAQLTGNEGGVAIEGSPLFGLTARRWSTAELEAARHTPDLKAGDKVWVNVDYKHSGVGTASCGPGVLPQYQIPATPMDFGVTLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMT6</accession>
    <name>K1VMT6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMT6"/>
    <dbReference type="HOGENOM" id="CLU_472663_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMT6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853931" evidence="2">
        <location>
            <begin position="20"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="577" mass="61158" checksum="8058374E9F7F5873" modified="2012-11-28" version="1">MLTRSLFSVVIALGAGAFAAPVDNGEQPCDSCHGVEISHGNGTAAPGGWGHWGGGSWNGTWAKPDFSKGAEQWRKLSSSSNQSSSYKKVWTWKWTQTSSSSSSSGGLPVGNLVISAPEGKGNVTLSTGADKDHAPIQLGPIGAFGHFNIEEWKTKLANFFTTEKIAEIKDKVAECIAKYNNQARADEFKKVFEGYFTAEKIEAYKKDFKITYITEIVNTFKQFRPEFLKVVEGTTYQELKAKIDAKFTTEKIKEIAGKFQIELNDSQIEAIKGLYNLYFTEENFNKLKALAIRFLNRDGPIGGGDSTASSTASSTSWVSSAQGSSTLASDSISASATASGGASAATSATASGGASGGASGTASATGGEASATGGSSQTQSGSTQSQSQGSQSQQQSQTQQQGGSNSSSQGGSQQSGGDSNSSSQGGSVTGSNSGSNSNNQSNTQTGGGNTNVQSNTQTGQNSNNNQSSVQIGNNNQSTQTSIQNYINGISYDQIKQYLQYLPAKYQISEQKFEQLKQKYVTPENIQRFSGLAQDLQGIKTSSGSWNWSKLIELKNKYWTPENKALLNQIKADIESGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMW1</accession>
    <name>K1VMW1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-glucoside:hydrogen symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMW1"/>
    <dbReference type="STRING" id="1220162.K1VMW1"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="K1VMW1"/>
    <dbReference type="OMA" id="WITLTYF"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="71"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD05535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="541" mass="59968" checksum="0461CD92BA6E79BE" modified="2012-11-28" version="1">MVDVEKTNAPVIAYGTDDKLGMDDKDMVAHVEVIDGKGVTEWDAIRADAIKAEDAERSLGLIGSLKAYPTAAFWSFAISLLISESTSLIKANFRKKFGHFNEMIDGQPDYQLTPAWRLAVNQAPNFGCLIGIFFAGIMQDRWGYKRTLQIGLIMLTGFIFIVFFAPTVEVLFIGEFLCGLPWGAFSSSAVSYASDVAPIGLRGYLTTYVNLCWVIGQIIAAGILRAANNIQGDRAYQVAFAVQWAWPIPLFILVTCAPESPWYLVRKGRLEDAKKSVSRLAAKGSKVDIDATVAMMVRTNQIEIDHSSGTSYLDCFKGTDLRRTIIGCMTWMCQQLCGMSLCGQAVYFFQRAGMDSNNSFNMNLGVTFMAFAGTILSWITLTYFGRRIPFVSGMFVMLVCLLIIGGLAFTHDSNAKWGQSALVMIFVFTYDFTIGPLTYCIVGEVSSSRLRSKSVGLARNAYNIVSIVGGVLNTYFMNPTAWNLGPKSAFFWAVSCALALVWCYFCLPEMRGRALREIDVLFERRVPARKFAKTEVDDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN40</accession>
    <name>K1VN40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN40"/>
    <dbReference type="FunCoup" id="K1VN40">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN40"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="InParanoid" id="K1VN40"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="554" mass="61333" checksum="9872D91CF7823EDA" modified="2012-11-28" version="1">MRAHNVAQLTGALLAANALANEASFKASNVDGFFVEQFQEQIPEGRWTVSRATKQTPVGDETFSYVGTWAVEEPEVYPGIKGDTGLVLKSKAAHHAISTVFPEPIDPKGKPLVVQYEVKLQKGLECGGAYIKLLTEENGAKALRDGEEYTDKTPFTIMFGPDKCGATNKVHFIFRHKNPITGEYEEKHYTHPPAPRISKTTALYTLIVNPDNTFQIKINDEVTAEGNLLEDFKPPVNPPKLIDDPEDSKPEDWVDEEMIEDVEAVKPDDWDEDAPLMIEDTEAVMPEDWLVDEPRDIADPDAEKPEEWDDEEDGDWIAPTVPNPKCDEVSGCGPWVAPKIRNPDYKGKWTRPWKKNPAYKGAWAPRQIDNPEWFEDPHPAELEPIGGVGIELWTMTEDILFDNIYIGTDPAEAKKFADETFHVKKPIEQAAEGSLADDDEGDLSLSDKIRLKIYEFSDLAKETSLLDAAKALPEVAAGLTAALVTFLALLLGLMGLSGSKPKRANKTAKKPTVVKKKVTTTTTESPAGKVTSAKIEEIDSEGDVKVTQRAVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN75</accession>
    <name>K1VN75_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN75"/>
    <dbReference type="FunCoup" id="K1VN75">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN75"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024645_3_1_1"/>
    <dbReference type="InParanoid" id="K1VN75"/>
    <dbReference type="OMA" id="YTHIMSP"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="62896" checksum="6CDD468B89F925E7" modified="2012-11-28" version="1">MSASSSSPPGSPPLAAISTSSMESSSGSQNKGGSPTSRAPAARLALSQPGGTNSGTSTPYMRTPPIITQFNDSKSYPGFQPVTMMPAKDRDQSPPKLFGIELKWLSLVTLALQNAFLTIIMHYSRILTPPNRTYSAAAAVLMNELLKGSISVLIALKRIDDSWTSSSQSNWPERDLMGAEKPASQPARAVRKGCSMFALSRLNALRRSVFSPDCYKLAVPAILYVIQNNLQYVAASNLDVATFQVTYQMKILTTAFFSVLMLRKRLNRSKWIALVLLAIGVGVVQLQTTSAPAHAAAAAVESASVSDKALRDISPDVTEDVPLSSDKPLLEDMAMHPFKGFMAVTLACLTSGLAGVYFELILKTGSGGNSDLWVRNTQLSLFSLIPALVPILFTSHNAGMSWVQNVASKFAHFNGWAIGTVLTQTFGGLITAIVIRYSDNIMKGFATSLSIIISFLASVVLFAYPITSTFIVGAAIVLLATWMYNQPGAPDAASRSTIAVAPGSPIPSTAPILGEPTPVRNNSVKNLLGLMSRSNSRAGSRRPSANDLRPLASTSMSRSNSFSPANSVQNSSTNLVGLVSGSPPPKGSAKGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNX0</accession>
    <name>K1VNX0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNX0"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249816_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNX0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="881"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1349"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="652"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1142"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1357"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1478" mass="162870" checksum="D9545941674634AC" modified="2012-11-28" version="1">MPDSVHSVGKEDEKIDVAHIDHGVDAATVLAAARMADPGPGWSDPRWYNFMAIVTIACAASADVGFDGTIIGSVNSMDTFHKYFGLQDALTGTNIVFGIYTVGMVVAFFPSIIIPDWIGRRWAMFFGNALLIMGCFINGYAKNMDWLLAGRFFVGLGGTLAGTAAKVYLAEVSSPWNRGFVLGLSNCCWYVGNIVATGVAIPYGRRNDDSSWRVPFLLQMTFAAVNFLFIMLCPESPRWLYARGKKEQAARILANLHSRDDDVNSPLVQLTMTEIEENVKQDGADKRWWDFRPIWRTRGDRYRFGLCVIVACWGQLSGNGMVSYFMPSLLKEAGITSGNEQRTLTLVSSVVAMIGAMSGAACIDYVGRRPLMLGSEIWAACCLGIIAGLVQPNGVQNNARSKAGIAFIMLWNVFFSFGWTPLQGLYPAEILSYEVRAKGLALQGWCAAVFSLINTFGIPDAMKALGWKVYLIFMCWDVVGCVVIWLFVVETKQLSLEELDDVFEAPYPKARSVELRREAKLRAREHREAEGALQLQPAQINAKKSQSDGTDQHADWAWGLAHNSHSVHHARSGTPSTCSSFHLILVLRLSQPRELPNRYRKLTHRTMADLSSYEGLTWAPSTDEDNSSSGSSCDRGWVCPSSSDDDDFHWPSSSSREGLLSPSSNSPEPSWSVISSHPGDSLVSVDAPNSANVAGSASGDVADDLGGDDAAYLEFLLNQWIEGTLPASVPIPSGSSAPYMHAGGPNPAETPLQQLQDRLWHYEASLNTARQKEAMAATTVWLHQEQLTPLYGPRNEVIQSRAELEEAHKTADARPHSSPLEVHHRMPACRILPGVPQCAGCLDKGVECSLLSQPDEFAAFYNSIHLSYAEVLQAGAWKPIPVAPAAKPPKARTRPSRAKLRPTPNEQDEHHTRNNNGDTWNGHPGWTPEHAMSSTDALAPRRNPARDARTGKELFWNLKETDTVVFRQSDSRAPRTWRTNQSPATTFSLKKDPFQARAIVSIDRSPAATSTTSLLSSLSELSAAASAFMGNSAAMEVDRRRPHAPSPPHARTAVHMNRFSVPPSVVSEATSLGLELLVNVALQSNHGSVSDRFLPDYTEGAPLSHPHPPVSTPRSGTVPHDFYGSSVDTFNSPRYHSRTLDQDTTQRVLPQLETPSPRSGRAHQLGPAVAPPAHSQPKRRLWWQVNTPDENVSNLPPPVAPHGGSADRAAAQHSKSAWANRSKSSEPPQPTTLNKGKKRTHEVDSEPQYNHDDHMDAHHWVSDSPPARYEDHYVSFGSVGLPSPPTQMDPRLPFQVAPPVFRRETFQNNPPPTELYRADHFHSRHKDLEPRDAGRREIRYELHTGRSFNENLATNLPSHSQPARASSSRSVRPRATVPINSSHRRAAMQPLETIFRSVLQATLRIYRNDPTEVTALDKLNDAFLIALADGDMSGVQSAFFQLVAKALLKQNGRAKKNTERGMEAFKDMCEMIEKKSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPE3</accession>
    <name>K1VPE3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPE3"/>
    <dbReference type="FunCoup" id="K1VPE3">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPE3"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_5_1"/>
    <dbReference type="InParanoid" id="K1VPE3"/>
    <dbReference type="OMA" id="DVQMSFP"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="238" mass="26543" checksum="08CDF3F2DEB0A89F" modified="2012-11-28" version="1">MSGKILIHHLTQSRSERIFWLLEELGLPYDVKVYARTKEGKGPKSLAEAVPMGKQAPAITLPDGRTITESGFIVNQLLSHHPSASTESTASADSIFWNHFSEGSLMLHLQSAFTSNKIAEGFGAYKILYLLLFFQGGIWAFNKFVQGLEKKNLQPMLDYVEEFLGTNPGFSGNDKLGEGDFMMIFPLSAIAKGGRGPYILGPKTEAWVKRTEQRPAYVRAMQRMKEEEERQVTGPSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPG3</accession>
    <name>K1VPG3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPG3"/>
    <dbReference type="eggNOG" id="KOG3508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255391_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPG3"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="699"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1384" mass="150751" checksum="64392637A4ADEDD2" modified="2012-11-28" version="1">MTTPAWSFESPVEYYIAKNSLNHGTFLREVPVGALGAQSTTQLPASNGSSSSGGLARQPTLGRSPRPSPKPSPITPTAPSFVSEKRKSGSGRGISKAHVKHDPSPERRLANRWLKGKIGLSLRGTGGKDGGELRIINVVPPVKPGDKPVRRRCIFSHAITMEDSWSIPDIQHLHPSVSGRSFGLALKLRETVEEPDGRDTPPVPPLPGIVSPKPALGSAVPEEDVFAIIASGPKTPLDGPSEEHLPTPSERSERAVRSLTEPSAAQSLGKELLTTGKKFLRRRQASETGKGWKAFGRSRAKTLSKVPGEAAPAPLPASYGEDDDEAALLRPHLDESERARRAAARLSPMTPFAPGPSLGSSLGLGNGPKSPSRASLLSGIGAPSFVNTIGGESSASESEHVSVTEVEVSIFISFASAQERDEWFTILRSLAQVEGSVEGRIVRPHRRLKINVLDVTEVSGPLSVNMDRRTPNGSAIETDEKSSHLSVSGSDVMSSSGSPGRTIRSTGKDYEQSKKVKPGWSWKERLRVELVLDERLLIARTAWTKAESPNGTAFWGEQFGMTEMPPFTKCQLLIYRAKDKDKTPVLFGQVDLPLVSSFGKSEDERYPVRSLGGALIGEIRLSVSYQEVDILPLAEYNSLWQHKDQTLTTPQQIMHKVEGPKLLYVLGGRGLMEGTMEYLARIALVEKVLMPRVLDTCTLEAKAAGSTLFRSTTPLSKTLEVLMRMMCGEFLQAALGPTIKRTVEEKIEPKLFCNYGDPERPPLNYRILKDVTGLVEQCWANMYAHRGLFPNFIRHILGHLFVTVREFHDDGDDLLRYKAVSSFVFLRLIGPALMSPHLFGLSECLVPSAQQRTLTLIAKILHTLAFFSDRDLARHPDLALFRGFIRRNNHAMLDFLTSIATPVGEIEDLFPEPTRLDDYLDERRGVLTEWEAEALPHMTFAGCIDLPADWAVMLEIWAENLAKPGLKLNVVGCRVDDIQDMLDKYQGYVARIHALAFPEGRSQGGNGRASRASRVGSSSSRSLRSLTSMSAKSEDSLPMLPRKWLGYTPEDEKRASRGLSITPPQSVSVSPSSSRPTSTHTRSVSRSNSPEPSRAPSPVLEEEERIKVTLRPASTLIDRAPSPAAERVGVERSLEPPSNIVLTSPHETTILLSGSPSPPVPPKLFPPPVPLKAKLAQRTSSLPDRPAERERPTLPEKPKSPTRPIPPLPDYEADTPDSPRVPIPIPEDVDGPNVVSPTAPGFEEPESPRFALAKPPAEPHEPPQPARTHEPAPARYAAPGTQETETHPPRLAAWRARGGRCVRRGPAPAPHAGHGARGAGAAASQVERERQRAALTFSTLSHHTALGPRATPITLHTPTTPSLHPTSLPPPSHLRPPPQRQSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPK9</accession>
    <name>K1VPK9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPK9"/>
    <dbReference type="STRING" id="1220162.K1VPK9"/>
    <dbReference type="eggNOG" id="KOG0051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390386_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPK9"/>
    <dbReference type="OMA" id="DEMVQHS"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="375"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="375"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="427"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="429"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="707" mass="80822" checksum="EE68949819F35977" modified="2012-11-28" version="1">MAPLHNPPILSRDPNPISCHQSIHPNDTMEMLMAAAEASSSSQRPRNPRAINDHVDNSPGFVSAMRSTAYEDDESDNENDYYANSYSLSLRGRSSLKSPRSAPRSPLAKKKKKTPVAFDPKPLPESMVSPDHSEDEGFNLGEVTARKDLPVNNSFVTFNAFDPPAGMTPESTGAEVEDTAEEEPVEPVEVLQTPSPAVQQEEPEVAQPSSVHEPPADVEWSTINDPTDPTKTPCPDGITQEQWHVALKIRHNKSVAWSDYTPELLRAALPTQAAIHEFLASRWIPIKELHRLESFGVFTYKRGKFTDAEKRSLRMYLEDFQEVHQLSDAELVDLLMSKGKNTEKNRYGKFWPELAGAVPGRPVRYVKEVVKRMYDPRGRKGEWTMEEDFKLKQAYELYPNQWVKIAEEVQRTEFDCRDRWKGELKGRDSRKTGAWSEEEVQKLIEAVKSANVAAGLDPLSGDTPWDVVVTNMGGTRTRTQCRKKWQDSLQGGRAVGRKTRVGVDHALLINRLRELDYQHERDIEWMKVPWDDQVKPATLRSTWSVIVRQVEDQILDKLQVYVKDQAAIEKRKADQERKKQERREAQAKLVEDAKARAAERQRKQEKKDKKERKKAKRAAEAAALLAQDESFVAPEPEPEPVEAVPEETEKQRRKREKREKRERKEEKRKRKAAAAAVEEEEVLKKPRIEELEGMTPGAARKTLWWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ60</accession>
    <name>K1VQ60_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ60"/>
    <dbReference type="STRING" id="1220162.K1VQ60"/>
    <dbReference type="eggNOG" id="KOG3207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1428927_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ60"/>
    <dbReference type="OMA" id="ETGNEHE"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="190" mass="20844" checksum="D99045CD612FF672" modified="2012-11-28" version="1">MSSEPHASGSKLPYSVGNRYIHAKNKAPLTLRYIGTLPPGSDDSQLWLGIEYDDARHGKHSGTFKDAPVFQTQQHGAGSFVKYTPGSRPLLYGETVVSAIEDRYGSLIDQPDKEEEGAKNREEEAVVLGSSNAAIVVEAPNMDSVRRRIKNLERLREVGLEGQSICALGGDNERRSVLKERLKSELVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ90</accession>
    <name>K1VQ90_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ90"/>
    <dbReference type="HOGENOM" id="CLU_832052_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ90"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="334" mass="36049" checksum="D40B3A2685940C04" modified="2012-11-28" version="1">MPSVLHTIRRMTRDDVRSSPPAGPARAPTRRHGWIAPPLAPRPQRASTDSQDEHPEEEYTFFGTPRIASSCSCTGCWATPLAHNPATVAATVRARKPLPFLPTRRKPAPKLDKDELQAMREAYPTPPPETQPDPLERCASPVSVDSYAASQDEQDEPPSLPDTPPPVPEKDDVQAVRAQYEPVSAAELKSLYDEIWLSLPDDADTSLPASSTVSTTSIPGSAVRSPTPIAAPPPPSPVTSTSGCALLSRERESRRPRPLAQKAPPADTELALLCHRGSPRCTTHAPGVAQLDEAPARTGGSHEKGHAHEAERRPTAAPWRSASDRLGSPEVYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQE0</accession>
    <name>K1VQE0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_02790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQE0"/>
    <dbReference type="eggNOG" id="ENOG502TKSF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1396249_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQE0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="187" mass="19889" checksum="F6B62B7AD18999F9" modified="2012-11-28" version="1">MAGFLLGTGSGLLAGAAVYYTLSTELEKNTLNLRNELRRSAQLVTASFTQQEPAPAFSGPISTYHAPTSFSTTLKQRWNHAIGSAVETVRETDWRVVAENAWEEGRELASRLGNNATAATTGPVPENELAALATSAGPLASQEVADVKKAAKNIADDVKMAELKATTHVDRKPQASQAGIESPKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQU6</accession>
    <name>K1VQU6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQU6"/>
    <dbReference type="HOGENOM" id="CLU_1391121_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQU6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="196" mass="21199" checksum="5A5E15C9BC20542E" modified="2012-11-28" version="1">MPRQQPSLLSDIGSALASSLRYPACPDQCRCRIYTLRLPLSFSLTLILLFALGSGAGAALFGLLFTSSPYTSILSLLLATLGVALWVRAVVWDAKWERAHSLDTDSTHTWHERVPSPTIGRGTSSERGAVRVKVPTTLGLLATDVLRAAAQVGAAVFGFFWLSAPMPGSGWAALVGIPGLWCVLLWRHWRQCSILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR12</accession>
    <name>K1VR12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR12"/>
    <dbReference type="STRING" id="1220162.K1VR12"/>
    <dbReference type="eggNOG" id="ENOG502S411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_0_2_1"/>
    <dbReference type="InParanoid" id="K1VR12"/>
    <dbReference type="OMA" id="DNDAYGH"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="154" mass="17428" checksum="34CD580DAEAF0804" modified="2012-11-28" version="1">MSVNVLKARLRSQYRYFLPFRLRWADNDQYGHVNNSVYNYLIDSVVNTYLIEHCGLKPTDPNPSEPIGLVVASNCNYFSSLEFPGVVDLGLRVSKLGKSSVTYEVGFFKEGVDSVSAVGGFTHVFVHPMERRPTAMVDQMRKGLEKLYVEEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR52</accession>
    <name>K1VR52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000374">
        <property type="protein sequence ID" value="EKC99192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR52"/>
    <dbReference type="STRING" id="1220162.K1VR52"/>
    <dbReference type="eggNOG" id="ENOG502QQPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044864_1_1_1"/>
    <dbReference type="InParanoid" id="K1VR52"/>
    <dbReference type="OMA" id="AWLFCPA"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="344" mass="37258" checksum="A96CA59B405C251F" modified="2012-11-28" version="1">MFARNAVKFKAPLGARGIAVVPNDLPPVLRRAMLYGKFTPLALVPPYRGLPGSNPRMLEKSLASPADSISYDLEDAVAPAQKPEARRLVSDMLNSGKRPKGEVMIRINAVGTGFEEDDVKTALTTRNVSAIALPKTNSPDHIAWLVSRINEYAPAERRTGGASPMRIVGMIESAEAMVNIHEIAASGQGHLDSLLFAAEDYCADVGITRTPSLQELLYHRSRLVVAAKAWGLQAIDLVCVNFKQPEVLARECEDGHRLGFTGKQAIHPNQVEEIQRAYAPSDKAIRKAARVKFSFELNDQAGKGAYALDGAMIDAPVYKQALKVLSLASAAGLPIPEITEKDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSS2</accession>
    <name>K1VSS2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSS2"/>
    <dbReference type="eggNOG" id="ENOG502RWPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_230607_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSS2"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1387"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1438"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1503"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2074"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1514"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1550"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1600"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1733"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1759"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1770"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1787"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1811"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1837"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1848"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1861"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1903"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1923"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2004"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2142"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2209"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2250"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2299"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2323"/>
            <end position="2348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2348" mass="249361" checksum="C58EB5DE0A96CF05" modified="2012-11-28" version="1">MTTAATPDRSPMYNHFAPATPPRASPLRSSHPQPGPSPSPRHYPSPQRSSRPPNPGSSYAPGSPTRLPLYQTNPNTPPQKYRVTNPDPPSPLLSDSQSPMQQAQASRAQSPHRQQLPRAQSPAQQQQQQYRLQQQQQQQQQQQQRQGHLMSLMPPPPQPSFAPAASSPLKPHNGNNRDATSDEMYADASESDEKRSKSSHGSNNSGRGVRMSKSTEFLRNLAGKGKGHAYTELNGEDDDEELLRQPEPAQQKRHSLASLDLRRGSPGPEAPNTAQSNWTGSKEALARGFPQPPHPGSENPYLSDHAFSSQDSFTTAQGSGGATSPIPPVVRGKPWPAHASPQTAGGPQVADPLVPVDGPHSRSDLFAAETGGMLMFDGENFQRGRGPSAASNQHTQAPASDSHSSDHPSSNGSSSRLDFTKPRAAPMPDWNEPAPPMSWVAPADWTSEWSQARNEGQSRRPTRHARSYSDGMQLLNRQGTLLHPDSSGERLSEELGLMLGKPRNRRLSTGRLLPPPDTSKLKKPEPVRLEASKKRRARVELDVVLERECAIEGGDLRGRLEVVVHGGKRSNALRVGHGKVRVIGFEEVDGRRHIFYQHQYPLPVFQHWANGPRTTLFADPPDGEGFCAAKEGTHAIPFSIPLPVGEGAKGTYTSHDPKGPNIRYVVVGSVKIFVPKKDKRAIAHFYRPCVILPYLNPAIVLAPARAPIMTQRTCGLGWNLTGEKGKVLMQVALGRRIWVAGQRVWCEVAVKNDSNKKITKCSLAVIQTVNTYLPKKGKQAMSREPTTSHRKKVAEETVEADFMDLGSGHVTGKGWWTGLEPGEGNRWDLSCPIPSGMLSIPRSCYVEVLFTLRVTLNNSVFVDMPIEAINFLSIDPPPMPGDTRRIGGRLPVVSPIGPASIAAGAGMAGIGAGVSGVSALETSGEGSTLTQMANGNLGTVSSNGGGYDLDQLRGRNATPDADRLSNANPSSTTLHIDTIKQNARLSQQGAAASQPSTTQPIGEVTEVTEDLAPRPGSPDSQYSTRGGTMASKYSVQSIDEDERNLLASEQARREGRHSIAQTLQIQQLQEEKEKLQRELDALNERHAASKGLPAGAAAAGAVVGGIAGAMAGKGSDAPAVEVTPDESDLPTPTASPQRGTLAVPDDKDDLESVVSGTFAPAHEPKEVSYQMGSDEDDFTDADETPHGSPNHSPTQGSLDTSLPPLQLAPRPLYLSHISEEEEPLDDETLSELMSEDAQHARHIDFGDDDDDLLAEPVSGFLESTPRRSLEDRLRSACSPHGEPASPTTPRAGSSHSESQEHSASSIGTGLANLDLRAGSPGARDTFGPPSSGHRSTSSVDYTEPIDVEDISMTDMEEEGYDADAVSSEAHGSVYATSPMAAAFQKHQQSQSLPGSWEPGSPWGARRGSRPPALPSLQSARDITWGGVLTGRTVSGRSLKVPFEEEPPLASPSSGTFGTISTGSASNSNGTPSTTRSAHYEHSGLVHDHESRNLAALAEGRDEFAPPRFARTDSAADSANQSFHTAGSSPRSGGSGSGGEQEQARMPTLAPSTGSSSGSDGESIPSPRQPEGPGPDSVFAVVKDSDTASIPDRFKPKPRVVSGDSMESHMSSVSGVSGMSDMLPSVRARIAALETRDTALRSFGPQSAASSTRVITPQSTGLRPTHTGTSFASAGSGLRAASPGLRGSRPSTPSELHLRPISPALTGGSVSSNASGRSKRKSYTSTLAPRAGDSGSSQYSMTPNPSQGGHLAVPGSQAEEYSETEPESDAELPRPRSLAEIDDETPRATHQTTFTQMSVPESESDQRASVLTTGTGSSSSTLRAGGIPPAPVRTSTLSAPSAVEAPAPSKSPVPRGPRPPLRTQTSKPNIAQPQTPTHVPSASIPSGMWLSGSPPAAAEEDDDSHSSRRYSEIHTVHTFSTEATTPRWSGSTRSSPSKKSDGSPTKPSGAFAKLTGRSPRGTPKRDLSPEPLEGFARGAQGAYAINTARGSRASLAAPADDHSGRNSGRNSPSGSPLASPRIGALGTVGEHRRNSLQQFIRPGPSSTGHGVSYAESPGYVAEARSPLMVRSATASMEGNIETMSDDEEEVGRELRSAGQRQLHLQIPAQTLPQPEPVPSPADGQPQQLLYDPQTESYVPAPAPSEYAAPRSPRSAASHAPSSPRAPPSPRSAGHSSSGHLQAPLRYGGAYQPGSPKSPTRSLGRLSPGMREAEPARARLTEAGSRTDRREEASSPVRGPAGSLVGSFDGVVKVKKEEGTVNDIARRLTYDELSRDRTRPRPPPRSPMRQPSSPKPKSKLEASSPKSSKSSQSADPSPRTPSVRSRKEKEKEGSVKGDKSRRESMRRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTB9</accession>
    <name>K1VTB9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTB9"/>
    <dbReference type="HOGENOM" id="CLU_055175_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTB9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="416" mass="47274" checksum="765FE619947378A4" modified="2012-11-28" version="1">MGQPRMPKSQWQGVLKNLRRINVNVHRKRECDLFAMLWRRKQTFHLDVLWLELFRCPEVNVNFHRRPNFPAAFVHNDVPEGLGPGQEHLPLVDSGCLRFCSYLSKGALWEARVRKVVVRGAQVMWDRLEREYQVPGGLGHEEMVLVVDSSGLWYRPPDTTLTCAHRRFDDHFAQREFNTGSEDELRNRLGESVCRWGFAPLDITTCCYTIRRMTIVFWSGSPDTPWTPPCGHFHGHPITGENEASSTCSAYTRMWFDLVEFAQQTALERMTIVNGDALAIPPGAPSDQTRIDPLSELRQRILGPFEGRAPVEPEVANSDYDAAQSDSEGGDLEPAESSDGESDYSQSQSDGGYGSDPGEWDGWTLGHKDNLDSGRPPQLLISSMAEWIESGEWEDVFSRKEIQPYLNAVRQERSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTH7</accession>
    <name>K1VTH7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTH7"/>
    <dbReference type="HOGENOM" id="CLU_740078_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTH7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="374" mass="42755" checksum="161288FD2C3D77F2" modified="2012-11-28" version="1">MGRRNKEYRFTKLHSTVPWSEQLRVVTHRSNKTVDELKIKYGDSRDNMELIERSKHVAVVFPFKCFCPGDQCPHARKDHDGYCPLFLRPSFWVFKRSQFLNQHKQDKLWNAYHDLVSEFPNILTPRKAKTDTARLESDSAHNFPVPEPTNRSQSHRPLHLGYWRRSSSEIFLTADTLQNGNYQRQVAVLRFLAILDQVLFGLVWKARQVDPLAIHIGACIAERAVIPNHKSLHPTAIDDAIRLAGGGHPLRLGLMGTTVAVADGFAELYHIDRKDYNHGGCYSFSFSVSPEDKVCKVELHCPTLGYRFPYDAGQLFGLQAGDLLHRVVPREGEKANRAHRLNFTVFMDASTAEDTQSRILKTRIPYVDVPPLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTJ0</accession>
    <name>K1VTJ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_01899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTJ0"/>
    <dbReference type="FunCoup" id="K1VTJ0">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTJ0"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="InParanoid" id="K1VTJ0"/>
    <dbReference type="OMA" id="YKPQTPY"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="492"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD03886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="622" mass="70055" checksum="AD8853C9AE1D7898" modified="2012-11-28" version="1">MALRKLQNRTLKAVAQGVETFEATFDKLNHASNATQKDKLENDLKTQIKKLQRMRDQIKVWLGSSDIKDKSALLENRKLIETQMERFKALEKEMKMKAFSKEGLIAAARLDPAEKARRDIIDWIVSTIDELSRQIEQTEAEAEQLQASGKKKKAMGDRLSELDQLNERRQWHIGRLEIVQRMFENGQINNEQVEMIQEDVKYFVEANTEEDFDFDLGIYDELNLQEGEEDYNADYGAHGHEDSSNIDTNSVADTAETPSKSSKADKKSKDHSDDTPPSPVQTKRSEKKKAEKEARKEAERQEKAEKAAAEAAAKAEAAAKAKAAAEAAASPPPAQPKAPLPPIRYAAAAAAAVGGSHPAPPSETSSSKKDKDTTSEEPAHPEPEPSPMASSSAAEPSNVSLPHCCGLADNQGQPTTTSATSATPSPAPETSVNGQQQPPAESSRAPSTSYSTSPRKEQGVLENLMASFGVAKDMAERRGADPNELVSQLDVSYHNAPAQLDAEPPRYYHPHSPIQTPSYYPQTRLPQLEDKSIYQRLELDQLFYIFYYMTGTYEQWLAAQELKRQSWRFHKQYLTWFQRAHNPQAITEDYEQGGYYYFDWENSWCQRRKSDFRFEYRWLSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTT3</accession>
    <name>K1VTT3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTT3"/>
    <dbReference type="FunCoup" id="K1VTT3">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTT3"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="K1VTT3"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="97"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="307"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="781" mass="87376" checksum="69592EBE6EA55AA3" modified="2012-11-28" version="1">MSEPPAKRSKPSSGASTPAENPYLAHMNDKNGSSSSNGVKNPLAGLVPRKVTADQAKAIMDADVNPFKGLAPFSAGYRKILEVRKNLPVYDKMDEFLKVFSKNQITVMEGQTGSGKTTQIPQFVCYADMPHLRGKMVACTQPRRVAAMSVAKRVADEMDARQAGVLQPTAGQDRAVQLGKQIGYSIRFEDMTEPGTTFLKYMTDGMLLREAMNDPLLERYSTIILDEAHERTLATDILMGLLKDIAKQRPDLKIIVMSATLDVDKFANYFGDNQPGGKAPIVKVSGRTFPVETFFTQEPEQDYVEAAIRTVLFIHQAEDEGDVLLFLTGEEEIEDACRKIRAEGEELANKGMAGPLLVVPLYASLPPHQQQRIFDPAPPPSRDGLPGRKVVVSTNIAETSLTIDGIVYVVDPGFCKQKVYNPRIRVESLLVTPISKASANQRAGRAGRTRPGKCFRLYTEKDFVKELEDATHPEILRSNLANTVLELLKLGIKDLVHFDYMDAPAPETIMRALELLHYLAALDDEGNLTPLGEIMADIPLDPQLAKMLIVSPEFGCSNEMLSLAAMLSVPNVFLRPANQRKEADMAKAQFTHPDGDHLTLLNVYHAYKANGGDKNWCWNNYLNARSLVQADNVRTQLKRNMEKFDLELVSTAFEDKNYWNNIRQALTCGFFMQVAHKEGERGSYSTIKDNQVVRLHLSCGLDHTPEWVLYNEFVLTTANFIRTVTEVRPEWLLEYAPQYFDPESFPEKSEARRALERVIAKKSGKVRSSDKKDKKKRKERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTU8</accession>
    <name>K1VTU8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTU8"/>
    <dbReference type="HOGENOM" id="CLU_307407_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTU8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="815" mass="90398" checksum="7DBD9994AF5233C2" modified="2012-11-28" version="1">MVPATKFKPLYKEDHEKQREAEEEILKADRHRFGMSEEEREALCQMMEQALKALDFSFEEMHGLASESIGTQGGTTSRNVLKVSLGWHLLALEMSAGKLNFDGNSFKWGARPRYLGCIGGKRRQPHSPPGRPTVHSVVQPDPTSAGRFAALPQQIRDLNECLLGAALIHLKAAGFAHIMGVNVVHKVDSKVTNPILFPQEIRRIVATKSEAFTIVRQSNVWSHSEPLWLQNTSYRYFLDFVQGSNVGLQFSSTFTKGGERYKMHIFVLDFENVSPLIMRLCHPLGSNTVLLPSRTARQRGLVHTHYQQDAGQPPIDRFYTAVRAIPFTNDVGVQIPGQALSCKQYPVEKFNKVRLLDLVKVAASKLLSDPFNPYSIAKPYMRNDRPTVMEIKPVGHRQMSEVPTTKADLAEEERSYELAYGFMENMIHKHVSTLLRLINITCPSIAAITLVVTHHVAKQARAVAHLVVGYEDFGHSDNVGIVGGIKLLCDLGIPSESWKLKWVGEAGMFSPQTPGETSDHRPGDDRRPTSSRRGRTSREPQREAREAALQSRPHQHPIHHPLPAPPYRYEVMILLALAKTRPDLTTLAHVKEAFLQWVDSPSSPLYRSTAALAALKAEAVDPVSTPSAMNRTKASVVQAARAQYAETLNLAAELGFGHATMTILSTADWLVRGYVGLSSPVAAKADGVNHLTGNDIVKKLIKIVKQEGEARARAGKVGRNWTQREDQVIAKLLRECIDRKGEGAEFSYAEATDLLPTRSRDAITSRIGQNRACFLDLVKELGSSTYVAQVPTKGKTRALAAMTDGGDGRPSKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU99</accession>
    <name>K1VU99_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU99"/>
    <dbReference type="HOGENOM" id="CLU_542044_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU99"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="616" mass="72021" checksum="A2053435AAEE2C3B" modified="2012-11-28" version="1">MITINHSYYPHVVDLIFDHAPPASLLAMAKTCRNWRRRSLDLFYHVKNPRVIKAPIVRHVSIENPLLGRISLSKGELVLLKGCKVLDITSRERRWRPWYLPNLETVRYHEGLAKLPRTHARRAVFRNHLPPFSRFLYKVKQTKQIVIYISKERGRLYWHKQALEHFPSAEQLVFIFDDDNANNNRALSEGTSSHVNRFDMDYDLLKTVKHVVVAAVQKKIRVMLVGTERWIVETFNVLKLGVERVYERYGDNLDIYRSISLSTLDVYRGFVGEEQWAVMTDWSGTLTPYRLRLTVHFTLHQSTMVIIDHSTFPHIIESIWSYVEEDDYAAKAVMAKTCREWRQWALHAFHHIVNLRVKSTWTLSFEWSRYNLQTITLRRAERGLLAGCRFLDIYYDREEDAWGDTGLADLCRFLPSLDTVRFALSEDQCHGQPVIPARQLVFSGVLPTLLNGCPEIKRIAIHMTYQQRYQVLDWPDLSELTGLEELIFIFEEPPWDLEVYEYAESDSDSDSGTDGDINTPYQSRNRLCPKLQLRTIRYTAQAALRQGANVIITGMEEWGQRLIDGLKLGIQWQIVPAQQAFASQNTLSLVNLCDYESFVGEREWEVQTIWDFRLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUH9</accession>
    <name>K1VUH9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUH9"/>
    <dbReference type="HOGENOM" id="CLU_1687972_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUH9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013107780" evidence="1">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="156" mass="17426" checksum="614B5409BA050BEA" modified="2012-11-28" version="1">MKVPLLLLLATPAIAKTITTTAFSIPRGECFRYASIPLQQLKWPCVDPTLDYWGMYAVCDTFMLSLTAAMQAYCPPGEFDHTWERIKDWGEEAKTTAPMPDREALLAKLAQIGPLPTIDIFAPGQMGSNQTRPVMITREAYDVGEHTDVSETRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUS5</accession>
    <name>K1VUS5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUS5"/>
    <dbReference type="STRING" id="1220162.K1VUS5"/>
    <dbReference type="eggNOG" id="ENOG502QW74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_5_1_1"/>
    <dbReference type="InParanoid" id="K1VUS5"/>
    <dbReference type="OMA" id="LRKPPNH"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000020">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="352"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="492" mass="54413" checksum="6618C7EAAC75DA0F" modified="2012-11-28" version="1">MGKRAEQAKKRKRQNVAASVAPAKRPAHDLPTPPAEELLLPEEIESAIDVLRTLAANPSLLQGKDMKDLKRGVYDLHRVMAEGATLGASLTSRISAALRDYRFTDALVLLFEMHARALPPKLGALQRWVRECDATSNPDGTPGDPEALRCLDMILRIAGDTGPEARERGEGEVSRALVKRPRVWTARGPVEGEISLWPLMRSETLFDIPPTLPYPGFKSVHFVRAHERRPPNLYDSTVWGSDDGAIHLTPAEQRRKPTKLDVPGLPGAFLVLDVFTPDECLQIVRAATAHGWEKDQAAEGSATQKTSILARNFVWLADHQFHDHFYNQIKEFVPQRAPDEEGRLGQGGRVRGINRRFRVYQYTENQLYRPHIDGAWPAAGLSPTGEYMHDSQPADDPLWSRYTLLVYLNGGSDIPDETGCTTFFTPSPEVGVMDAHSVRPVQGAVLCFPHGDTHGSLLHEGSAVGPDGGKLVIRTDLLYEAKGYGQFKPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXA6</accession>
    <name>K1VXA6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucoamylase s1/s2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXA6"/>
    <dbReference type="eggNOG" id="ENOG502RBE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004516_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXA6"/>
    <dbReference type="OMA" id="HTMPANA"/>
    <dbReference type="OrthoDB" id="2564946at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="971" mass="102745" checksum="AE8EFD7E9FB25BA0" modified="2012-11-28" version="1">MGIFRRFRAGTSSSTSGAQPDQKAPVDPAKSQQSTGQKFVRRTPSLNLLNGQPRASTASNAPSSPTTPAPLQPQRTGGKLPWSSRKKSSEPPSTDRGYDDISAPPPRPAFSTPSSPSLHSQNGRYTPDPTSVPTIATTSYDSPSPKTPSRQSYGPRPPSRPPPPSASVHSRPGLTVSPGSHASSNGYAGINVHHRSPSQATVISIDSTFTGGSRSSLEWKQEGGILGKLGFEDDWGGLGDTLPLQNANGQPSAPQQRPMRSDLREDPESTTSAAARTSPVKKITTAFSSRNPSSTTNVPAAPPVLSPTLVDTTEELESRSSHQGDPRDLPDEDKRSKMWTRGRKSSRSRTSDAPDSIPPSSPPKPRRSSSQTGDQSAALRRPSSNLFHNPFGRTTSRSSLPLDQAAGADDGSFQLKSFRHISGASGADSKLDQYFNLSRSSDAPLSSGGNTPSAGPSPRHEVPPTYTTPLTAPPPRPRLSSAAGSSGSQQNRVSIAEFRKNIRRPSSSMLADAADGGDDDDMPLSMSRAQLRAEAAIHRNSSAISLGSDAPSPSPSMSRLMPSVSPMADKERKLPSSSPLSRPQSAFLLGANDAVSDSAKPRRSSNDPNLARAKQERTWPDSPTASEASTAASPTTPTGLREPIRGPRRRDSLKNIRKALPPAPEPHTMPANAVANALSQSTSPVKPTFASGLTDAPGELEGIKLPPRPDEIPDEPVRGSRPPSRSTTLSPGLTAVLDEPLRRISGLWTGTPNADNDDKEEAFDPSIIAAIGNGPPPIGMGERQRTASEGNRMSIYDRLNSVTSAVSSVVPSPMAIMKGEDPNKLFIPPVPDSPEKRVLPQSPASDRTASPVRVPPPMTAPPAPPPTMPHSSFGRPSRKQPEKVRTRKEAVGWDTSSEDEDDVKKSSPVIAAPRPLKSAMKHPSRTDLMSTSPAPAPAPSADDSEPDEPLVTDHHRSAWVSVSALPPRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ15</accession>
    <name>K1VZ15_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ15"/>
    <dbReference type="STRING" id="1220162.K1VZ15"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ15"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="436" mass="43617" checksum="C69A0421C93B41B8" modified="2012-11-28" version="1">MLANSRSTLAEEVIKGVEAAGAIAKPYQIQETLPAEVLQKMHAGGSLKPKYPIIDALTKPEELKELDGFLLGAPTRYGRLPAQVSAFFDTTGQLWASGALAGKFASTFTSTASQHGGQETTHLTTIPWFVHHGIIYVPLGYTQPYLTDLTDVHGGSAYGVSTVAAADGSRTPTQGELQLAKYQGEYFSKIVGQFVAGKHTNARRLTGGAIGGHQTQNVASQGQTGQTGQTGAQQGQGHGAGTAAAVGAGAGAAGAGAAYAATRGVNSQGDREQTFTSVSAETPGAYNETDYIGGQQPGQGQQGQGYSVSGRPDETSRQTGAGTGATGTTGHPSTTGTTGQTGTTGTGSHTGTAAAATGAAAGTGAAAAAGHGQEGTKPSAHKEVPEAVVAQETIVAEGTPTATGTLAGGAAGTKPPQAQQKKKGGLFSCCSTSNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZL3</accession>
    <name>K1VZL3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZL3"/>
    <dbReference type="HOGENOM" id="CLU_1714612_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZL3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="153" mass="17585" checksum="9B7DD37140CED624" modified="2012-11-28" version="1">MCEASAHAAALCAIVDRMSTTGMGDVMLDLFWVYLVFTASVVLYQYHTQLQRNRRRDRLHAQLLDISSRINILEEQRDRQLAHLDAVILRRAAAEEELERRVEEGRSVESVAHAEIRLAEMRCDEVYWAQKVRETVVGLADMYTLENALAHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZL4</accession>
    <name>K1VZL4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD05007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZL4"/>
    <dbReference type="STRING" id="1220162.K1VZL4"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="K1VZL4"/>
    <dbReference type="OMA" id="IEILQCM"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="257" mass="28168" checksum="37495FFB46D5A001" modified="2012-11-28" version="1">MIQIPGYQVKDELGVGGFGRVYRARRASDHKCAIKVQSEVTTTLGTILFRNEIKALRQLSHPNVVEFLDVIKCNDEVHLVMEFCDGGDLRTLMEDHLERGLYIHELDVKSIFVQLLLALHHCHQILLTTTGSVKLADFGLCKILHPGKTKAHSLVGTPGYVAPEVSAGAPYDAKADLFSLGCVLYEMCALDLPTLDNKAPCSTDSFIPKSFSSEMEQTVTRLLSQQTSVNHSPVGGPDNCQLAAGDLLFDRVGLHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZX3</accession>
    <name>K1VZX3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VZX3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZX3"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_5_0_1"/>
    <dbReference type="InParanoid" id="K1VZX3"/>
    <dbReference type="OMA" id="NINCMFA"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="809"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="7">
        <location>
            <begin position="1185"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="653"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1595"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1615" mass="178996" checksum="6A269F8A305006EE" modified="2012-11-28" version="1">MSLPPGQRPGGARPQRPPYGHPAHPGHPGQPQMGRPSSRNAAFENIFGRPAGGHHLGGPGPMAPGPHGGPPHAQRAPYPGAPAYPPANPAQPSFPPTQPTAFPHPGAPKPHGGAPNPYSNYPAEAYRAPAQQQGYDASNSGAYANMRGPSYNPQIQQLQSADAVPNRRTSLNQNTQSGRQYLQRAPTQTSYNSYQSPGDRLPQVQERLPHISVIPNGGSGGGSGQPVAPLQQQKTGGSVVMPHPRSMSGSAATGLQPMTQASVPPRSRSLHHQGGRPPPQSNPSQDSSRIRVNIPSPTISGGGIMPFPEIQTESTISGRHSHDQDSTDFSRAMSDLSLNNGNDSMHATTSESSFYADSISGLPRDRRSDHHLRAWDGGQEPQERLHDINPSRQPVASGSKMPMHRRQPSDSSIASSIYTVNGRMAPLSQIDNTGLAYDSAIGSPTTPNGSENGYPTMNRVTRKSMESTHSLPLPQESPLPPGAANSVYDHRAMSFSGSGVNRRDVVQAVRSSSIKSPSGSGIGALGITLDNVGNSPVKSTKSMKHSTPPIVPADIEVDAIPALLSTVAEAFRTIIKPTEMIKDGITYKDAFDGRTAVTLIARIINTDDRNLALLLGRALDAQKFFHDVAYAHRLRDTPNEVYQFKERLVAPFTQPGAADSPSSDHLNLLRPSSTGSAVRGGGAAPSIHSTNSVFFNNATGGGTPRPSPGVDGATPQSSDDESDDLPNGVFTLLTECYSPTCSPDALCYSISCPRRREQIERLNMKSAHPGLQREVEDNVDDVIVKPTGTLWIDSVSQEILDSVDDQEKKRQEAINEVMYTERDFVRHLEYLRDFWMKPLLSSEVVPANRRDEFVHQVFWNVQDVLSVNHVLAERLTKRQKQQPVVQSIGDIFLECVPHFEPFVTYGAHQLFGKYEFEKEKGANPAFQKFVDETERKPESDKLELNGYLTKPTTRLGRYPLLLGAVLKYTPDDHPDKTDLPVVIEMIREYLKRVNTETGKSENVFELAQLERQLVFRQHENIDLRLRDKNRELVHKGPMKRRGGTQGENADLIAFLFDHAFLLVKSKWVNKAEQYKVYRRPIPLELLVLITPEDHFNSARSRKLISRGTNKTKEGVHVPPKPESRHGFSITVVHLGRKGYQIQLWVDTYQSRKTWVENIEKQQQIIRDRSTIFTSETISENYFQGLRRITCVSPYDNGNRMIYGTDEGVYFSNLRDPKLREPVKVINLVDVTQVDVIEEYQLLVVLHERSVTTFPLDCLDPNDPNAALKRGKRISSHTSFFKSGICLGRTLVAVVKSSPLSSTIKVLEPIDQNMRGKKPQTGFMRRLNGGQESLKVFKEFYIPLESFNIHFLKTKLCVGCQKGFEIVDLETLDMQSLLDPEDSNLDFVLKRDGVRPMAIYRIEGDFLLCYNEFAFYVNKNGWRSREKWAIIWEGQPTSFALQYPYVIAFEPSFIEVRHVETGHLVQIIPGHNINCMFADMPPSTVNAPPPPRQLMYGGQQPPPNMYGRPPQMYPQTTGGPYGGYANGPNGMAQQQRMHGPGYGSMQGRPPMPGMPQQYMGPQQMMRPPAGPQHNFAFRPQVIFTSDEHHVQFLKLPPRGRRGSDAKSIKSMKSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W039</accession>
    <name>K1W039_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W039"/>
    <dbReference type="HOGENOM" id="CLU_1367101_0_0_1"/>
    <dbReference type="InParanoid" id="K1W039"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="22270" checksum="CF2D7EB4EB7A7CBB" modified="2012-11-28" version="1">MQSPARVVEHLHNLPTKRVDVRLPPHQVDLDVLDPLRLRLILALPLLLMAAPPILNSADEAVLEAAALLTLRALRRNGHEGIPSLHTDHDPWIAPRGSPRDHFDELAKRRVPVEVAGLDLIPPSEGGENQVRVRAVDAPADRRQGTEWRSPRAPSRRASKSVRGVDLDHAHIGAVQATEEEERPPPRRECRSRVVEESPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0K2</accession>
    <name>K1W0K2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000121">
        <property type="protein sequence ID" value="EKD05342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0K2"/>
    <dbReference type="STRING" id="1220162.K1W0K2"/>
    <dbReference type="eggNOG" id="ENOG502SER1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1455375_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0K2"/>
    <dbReference type="OrthoDB" id="2574139at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF22">
        <property type="entry name" value="BTG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="186" mass="20559" checksum="8E94C0532BE8C271" modified="2012-11-28" version="1">MDPPDITGLSLSSQRTPPRAASPALATPPAPTNATPGAGLQLDMTLGSAVQALVHHLVQPLAAHYSHSQLMTLRQRLTKILTKAYEPSWNESNPHQASGTRSLISDRVHGLPPLLREAAGKDIDIPTWSKAISASHRKRAEGEDESEWEVWCDPGMVVWRWGGWGWDEPEFDPIRRPRGEYTVSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0Y5</accession>
    <name>K1W0Y5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0Y5"/>
    <dbReference type="HOGENOM" id="CLU_937458_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0Y5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33368" checksum="31439E904BF9CEC0" modified="2012-11-28" version="1">MHSTVATHIGIWHTTPSFKSSTTMPRTCFKDEFEEAMGLFSQRHSSFSTLKISEPLSVFSQHFTLVSCEGELISMPIYDLMSWSKFFRDLLQTGRGEKRVELEERAETIEQFKELVYGKRVTWREFSPTPFFEQVFALTAFLDKYDCPRALKDLVEILTRGASGPSTTATASGGTSTSQAELPPLVLFAVGARLAQPEVCEAALDLPKGSWAHYKPWTHPPGIGDKYRNTLHPLGIPFQLLEQLPYEYTLALALTPVKENIKPGYDKDRARNGREFAEQLSKIGKLKKAADGKRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1M0</accession>
    <name>K1W1M0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-glucoside:hydrogen symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000043">
        <property type="protein sequence ID" value="EKD05657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1M0"/>
    <dbReference type="STRING" id="1220162.K1W1M0"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973823_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1M0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="30979" checksum="39A8CEEDB1E19473" modified="2012-11-28" version="1">MTNQVQEGLPEEIGEQLESLMVVCDGPTATGRNAALDGEWDGAVKVYDKYPRFCELPYPRASGSVLTRSQGHCGELDAHQRVPGARRHQAAHVSTRPSASCGTSWSLPPSLEADTPGIQVLIVGELLCGIPWGAFSTSAVSYASEVSPVCLHGYLTTYINLCWVIGQFISSGVLVGVHTRCDMWSYKIPWAVQALGSMSAMVAWWSRGCGISPSEQVREGQASNMVAMMVRANQLEIDNETGTSYWDCFKGTDLCRTEIACIGWAAQVLSGSSFANMPTYYFTQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W284</accession>
    <name>K1W284_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 13 protein/putative endo-1,3-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W284"/>
    <dbReference type="STRING" id="1220162.K1W284"/>
    <dbReference type="eggNOG" id="ENOG502RECF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072653_0_0_1"/>
    <dbReference type="InParanoid" id="K1W284"/>
    <dbReference type="OMA" id="KHASMID"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="226"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="366" mass="39399" checksum="2A2817541B0719B2" modified="2012-11-28" version="1">MLPAILLLAPLAGAFPLLRRADVYEKHTYLVTVHPANQNGNDPPFLREKCLGANNGHLYNGAPVRVGDCIPGANFQLWESFGEGVFRVSGSDFCVNSPEGRQQPSALGLGDTLNKTEMTMSIGAQGSVTTTVYLTECSSKPIPQGQLWLTSARPNSADDRPLYYISPKPGSEPTSTDAKTEPTASSAKTESTATSTNPDTTATATDAKPESTSTEAQPTEAASTGRDFTLSAVLKDGSTKRCMDARGSELQDGSAAHIYDCDGNSAQEWELKSDGSETTVRLRSTTLCLDGGRPSNGAPLSFRTCRDKARTQTWRLSPRGHLSLADFNLCVDVRDGVPDNNTRLQLWECINENDNQRWSYAGHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2D2</accession>
    <name>K1W2D2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2D2"/>
    <dbReference type="FunCoup" id="K1W2D2">
        <property type="interactions" value="797"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W2D2"/>
    <dbReference type="eggNOG" id="KOG2928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018596_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2D2"/>
    <dbReference type="OMA" id="YDFELAY"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="197"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="443"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="518" mass="56354" checksum="6EBAEF124BB8205F" modified="2012-11-28" version="1">MPPRKRARADTAAAAPKTHTKRTKKAESPPPPVPTKAKSPTPADEPSASHLVSFLTSYTDRYDEREHGSDSDSGSSDGEKDEDFEDHADDDDDDETPTTPLRGLVGTPGRRKAPATTPRKRAAATPRKPKTPKKVEQEDEGFLRTSRADNYFMNATRGSKTSGLSYSALARPLSQAEYEGIVSGARGKTKAVQEKLEELARFFPQWASELETGFNLLLYGYGSKRRLVNRFATETLNDLGDVVVVNGTFPGLGLKEVLAALEARLPLSDEVPAPLGASPLERAAYRVYQSYRSGKDHLYMIIHNIDAPGMKAPKSLAALSLLASCPGIHIVATFDHVHTPLLFSATLSNAPPHPPTKDEIPSSRGFNWIYHSAPTFDDYDVELSYARLSSSAALGQSSGTISEEGALQILHSVPPMAARLLKLILLKQLDNGEGPLMGVGGAAPAYALDVDLVQKAARDKFIAREEERFNALLGEFKDHGLVVTAELDAEGRQGRWAWVPLPRAAIERILDEMKNVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2Q2</accession>
    <name>K1W2Q2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2Q2"/>
    <dbReference type="HOGENOM" id="CLU_375165_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2Q2"/>
    <dbReference type="OMA" id="PQPIQYY"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="78169" checksum="A1373FE4BD1CCD73" modified="2012-11-28" version="1">MGLFDGLYIFVQVKDRPSRDVGRDIRTIMVRLPPSLSNGTPLEGPADTAATCLATFPQTSTILHPNLRRTTAQPAQRLSPVDVRPPPVLLHVSVPGGVWGLTSPGVGGESRRERLPSNPSVKSNYAGPVRDISKDPRLKGKLLKSANDTQDDDRRRRSPPAKSESSEEDEPLRNRQSLKKRVIHSFTPSPHQTPRPSPPKSPVGLSVKASPKSPQSPTSLESRDLKGSTSLNGPAPAHKPAVPPITVSIPSAQNQSVQTAPSRCYVPRSVQSSAPPGQQEATATATANGGKASTDGKGTAPWSRLSTSSPPPGPTSLRASGSATIISTTATAAAGPAPPTSKAAPAPAAVLKASSVSGGEPVVSQAALIVSTTASNRSSASLTPLPSPVLSSTSMTYKSSAVPVRQEQPAPVAVSQPSPAPAAPPADTLPTPVTPATTVPPSAPTVAAAAQAPPCPPERAEPGLLAPRNPPMPLRMFLSEGLKRGTRNIVAVSLPILALANLQLGKASEVPLCDADYVIVSSDATKRRLPGPVPQWAVVVDEAWLHDSFLNDELQNVREYFVDPPASVPSAHPSPVALVASISPSAPSRKRKSATLSSAEIESPKATKSRAPKRPAPAPEPEPEEDMVIDVDDSDDESYIGSGDEADDGDGDGTDGDRDRAASAPLREPTDADISNVYWLVDELLKWDKRGPIRHQLERCSRDVGIPNARKLYYTYKEYIKKNVPDLRARRPYKKRARVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4F2</accession>
    <name>K1W4F2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4F2"/>
    <dbReference type="STRING" id="1220162.K1W4F2"/>
    <dbReference type="eggNOG" id="ENOG502S7T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353362_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4F2"/>
    <dbReference type="OMA" id="PGSANFM"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF38">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="657"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="686"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="105"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="357"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="401"/>
            <end position="415"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="583"/>
            <end position="596"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="816" mass="86081" checksum="F8E8F97F9DCBD6EE" modified="2012-11-28" version="1">MDSASSGLSPSSSQHYFSTLDFLSLAGIDGSAEAQSAGRHYGHDDDAPLDDPSPITLESRTSSGPGHSRNPSSPASFKDRKAAAAMDVDNHSHTHTPGASQTAKAHSSGHATPADELNNPVEAGSSSYDAMQAGMLQHQIHMQSPMVGATNPTSPYTNMASMFLTSPPSQQSAMSHSEGSSSQQSQSQSELARSHYQRKYNAAADAFGGILTPGPSGDLVPDVRMDLMSPMQLEMLARGEIDMENFHTVPLLSPALSGHSSYASPMVQAAYGGNANHHALQQLQHQQRHFQEQLQLLQEQQKQLQATAAAVAAATGSPYLMPQGSSSSGQQGQNQSQGQSRSQNGHHSQHSGGGAVSTPSPGSYFSPLTSPALEPAVSRSAALRAAAAHLSPAMHGSNQRAPHSLSALSSPALNPVGSLGGAQQTLSPALEPQGNNDLADPEYLNALQGLLDSNNSNTSASSDQREYQSPMLGPSSSGSTGPHRSLPAKSRPSPMMKPTHRHRQANSGSLPSSPMAFKVPQGGVGFLPPAAIDQRHHQPQGPPSNTPSPVDLAQIMPPPPVPAPSRPKSLMPMTPASLMNLKSEAQSSSGPSSSAPQPEPEAEADASKLPARAAKKAAAPKRGSRLVPTPPKRALAIRPPGGGARKAAATPATEPENRRTSHKAAEQKRRDSLKAGFDELRLLLPPINTEALDPETGEPIPGSSAPRLLPKSSLVPDDNPNRGVSKVALLKFSNEYIMRLHGKLDKRDAYIEKLRAEVERLREGGAEEVKGDEGEDLLEMDMTIGEEEDEDEEGMEVEPEIEERPKRRGSARKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5X2</accession>
    <name>K1W5X2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nonmuscle myosin heavy chain b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01354</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W5X2">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W5X2"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_8_0_1"/>
    <dbReference type="InParanoid" id="K1W5X2"/>
    <dbReference type="OMA" id="QARITNM"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="95"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1488"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1574"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="871"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1488"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1574"/>
            <end position="1583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1613" mass="181164" checksum="B629609264CAC139" modified="2012-11-28" version="1">MLTQPPLPPNLIFNRPIHKQTNHPPYDDDDPMADDNRRVWIPDATEGFLAGWVKSEPSAGDAAADATAEVVVSATGEMRTVPTHSLSPMNPPQFDGVEDIAELTHLNEASVVNNLRSRYGAGSIYSLPHLPQPLPPPSDLHFHHCFPVPIKAERREPSAHLCRRRASLAADRRGEGEPVDPDYSGAGKTENTKKVIQYLAAIANTNEPSSSGASAPLSGLPRSSSFKGRAAEELSVAPRSDGELGLLERQILQANPILESFGNAQTMRNNNSSRFGKFVRIFFSPSGAIAGANIDWYLLEKSRVTQRAAGERNFHVFYQLLKGAKEAGFADRLLLTEGPEKFDILNKTRLEIDGVDDLAEWRLLKEALDVVGFSEEEQFELFRIIAIILHIGNIGLTATNADQALMPPESQPVVEKVCHLLGISDKEFMKSVLAPKVRAGREWVTYPRSKKQAEDELGALSKFMFERTFGGMVSRINKALDRPNAKSYEQLLINFTNEKLQQFFNFHMFTLEQEEYTREGIKWDYVNFGLDLQPTIELIESAQQPVGIMSMLDEECIMPRATDITFNDKVQALWEPPKGSTQGPHPGSAKFKATRFSRGFVIKHYAGDVEYVTEGWLQKNKDPINDATARLASQSTVPAIKTMFHEYAEDATTATAGKRVKRGAFRTVGQRHKEQLNQLMSQLASTQPHFVRCIVPNSEKKPGKVEVNLVLDQLRCNGVIEGIRIARLGYPNRLSFAEFRQRYEVLVPGVVPQGYMDGRKAAGLIAEALELDPDFYAIGATKIFFKAGILAELEERRDNLLTDIFRRFQSAARMHICRRRINKLINRAQAVRAIQRNARAYISLRDWPWWSLYVKVRPLLAATKVDDELSVKRAELAMIKERAERDEAEKKRLEELKIALLSEKEKVEADLLAERDLAVEKDEMLKRAKEHEAQLQERVAELEAELEKVETARSEVSATGEKQRDALTKLQHKHDQLAQQISMLEKNELSWRNREAELLRTAKDRTAAHTKLENDKLAVERQLEDLRRDIGTKDEATRRAADKKASEISELQKLLAEEKKKVEMHTTKAESLQKDLQSRDVASKDLQEMIKAHEATLMAKSQAIADLEGKHSASVKAHEATESARAALQTKAESLASEIAARDRQIQKDAAERATLEKSLDELRKVMDAKANEDVKRREVEKSREAEMASLRQQVASLHQSQEKQRENAIALANKLRVDIDALRQRHSTAEKNLAASNDALKAKTSEAKKLESAADAAHKAKRAIETDLEQLKARLRATEGSLNGANSEVKNLQARLKEKDQKFADLEDALLPLEHERQVLRKRLDETSTHLAKEIATRQALEKSLSEHQEEIANHRNELTQFERELAQAAADIKARDDEVALMRSRENKTIVEHVHVLESAKKMTDRQLVEQVSENKKLNQILKSMETHRNRLQADLEDLQRSHDMLKKERSREARAGRASLGPADVTSAVLEEERKARAAAEAKAASLERDLSDIKRRQSTAPLNPLSPKRSVSSSSEGKLARALDEITRLQKSLDAVSHENRRLGSELASSRQKNDLLQQLQKSHDALGRDMSDQLKRLDSSALGGPRRQANGHGHAQQASMGSKPAFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6R4</accession>
    <name>K1W6R4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6R4"/>
    <dbReference type="STRING" id="1220162.K1W6R4"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046722_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6R4"/>
    <dbReference type="OMA" id="WAVENTD"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="368" mass="40256" checksum="478EB0CF37ACB312" modified="2012-11-28" version="1">MADLNTLLRWAIENSDKDKLHNEAAHAKDGGMQLKYKPAAPGQEPSKHNATLHKDDQGVSPASTPGPATPKEEKSELTTDIIDLILGKPDSATMKEKMEYATNPENDTESRVEALDDFEMLIEMIDNANNMTALKLWEPLFSLLQSDSPEIVRHALWIIGTAVQNNLKAQASFFFQDGFNKVLDAIEKNASAPATRQKGAYALSNALKYWPLASMWLSANNNRGYDALKAGVTDSAPPVRRKYAFLVGNLVMQAGTKYEGDMALPDDVKAQLVDKITAQGGKDGDLLKGLEDNGVFSALIEGMKMPDDNDVEFEENAIRALANAAEKGGLSAQEKTEAKSIWNKWDQEGQKERGFEGADAQQVTKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7N1</accession>
    <name>K1W7N1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7N1"/>
    <dbReference type="HOGENOM" id="CLU_1939598_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7N1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852311" evidence="1">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="130" mass="14343" checksum="572C4E4F742D15DC" modified="2012-11-28" version="1">MLHLPVTVALLASAASARYYYLHPQGQPQFCLAIDPCSGGDKREFPLVTAECDNSDNQKWATRLIGDTETITWYPLSAADRCINGNTTSDPPQQGQQVRVAACTPGQYNKWQDWARDGNQLIAGSLDETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9S6</accession>
    <name>K1W9S6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9S6"/>
    <dbReference type="FunCoup" id="K1W9S6">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W9S6"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_1_0_1"/>
    <dbReference type="InParanoid" id="K1W9S6"/>
    <dbReference type="OMA" id="EHNQAVQ"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="490" mass="52294" checksum="14221EB121B0F866" modified="2012-11-28" version="1">MPPQHVAVIGGGLTGLSAAYRLAPKAKVTLLEASNRVGGWVGSPKQHIKFTTPSGEQVEGDVTLESGPRSIRPKGLSAASMLKLTSPAARNRFIMNNATGKLMAAPTSPLALLSPKTPAPIRELLLGVMKEPFRRNSPASADDESVHSFFLRRFGPKVAATASAFVHGIYAADPNTLSVRSAFQMLWDYERGSGSLVMGMLKGDKAGKARELEAWKECGAWGERRKNWAMYALRGGMSELTDRLAQVCQERGVEIASGTRVERITPINTSIGSIDADHVIAAVTPRHLSSIASSPLPHLIANRSTTVGVVNVVFPLPPSQVHPDGFGFLIPASDANRAGVLGVIFDSTALPGTEVPELEGKITKVTAMMGGPYWSSYKTGGSVAPIPSKEELSEIAVNYLRTVFPHLASVDPILTKANLQVDCIPTYAPGHGSRMRELHEAIQNGPWQDKLSVGGSGYGGVSVNDCVYSGEILADAVGEKTGLERWKDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAD5</accession>
    <name>K1WAD5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_07110</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAD5"/>
    <dbReference type="STRING" id="1220162.K1WAD5"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418675_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAD5"/>
    <dbReference type="OMA" id="QSAMEWA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="17">
        <location>
            <begin position="378"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="122"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC98618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="726" mass="77664" checksum="5DEE9F15908B813F" modified="2012-11-28" version="1">MKLHAIAGIAAASGAYAAAIQPDGANAGALHARHDGGRWPFGGWRQHQTFDPCTPPSDLQDFHGEIEENGQRRQFDNWADFQRELQNQQSNGGWRKWAPWLFPATSCTTGAGSLPTLVDGKQNAAPTLSPNPTLTLGITSSADSEGTDTAVPETTDGVVTSTPDPNLTSTSSSTASSSANGVDSSLVVPSSAPLSSSANLVTSSSAEPLATTAIDPTSSSADSLSSSANSDALSTSSSAALNASTSSSVDPNAASTLAPTSTLPNATAVPTTNATVAPTATSANITTVPTTGTAVPSNATVLPTNTTQAPPQPTIHNNSGSIDDPSVVQGLDKIRGVNLGGWLVYEGWITADGGGFGSGKNWVDEWTMAQTYDQNKEYIDNHWKSFVTEADFAEIAAAGLNTVRIPVGYWTFIPTAGDEPYRGQVVTWEVLKQAFGWAQKHGLRVMLDMHAVPGPQSLDAHSGHKTDRAGFFFSEENKKRTIDALVVAATEFTQPKYGGVLKSLMLVNEPRLPNERRDEARQFLKQFYVDAHNAIRAIPAPGIQNMTILIHDSFDGAERYGDFRNVTGDPNVAMDRHLYSIFEPSKANWTGAAVLKAQCEQANSLVDFARKYFTVMVAEFGAPARGGSCSWFEGVAGIQNPGQCPGWGDEPDRVTWVKESLLAQLQAYETVAGWVFWTWKTANGDIGWDMKRIIDKILHGLLGVQRFDQITLDRCQYYNASMPKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDZ5</accession>
    <name>K1WDZ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxamine 5-phosphate oxidase, FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDZ5"/>
    <dbReference type="HOGENOM" id="CLU_1563993_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDZ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="171" mass="19328" checksum="51058465A3BF7E8A" modified="2012-11-28" version="1">MGLLRRSKTPTPPAPPPPARGEGDWRTLVEEAVKTSPTAKELSLATCTPNGPRNRTVTFQGSKVEQLKHNAHVEIAWFIPSGACQFRIRGVVTVIDDDFAQNKIHHLAPNAPELEHAYWDATKKAILDAMPPRQRHPLVMLALEPEHVQHLDLIKFAYTEWTEHEDERCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEM0</accession>
    <name>K1WEM0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000351">
        <property type="protein sequence ID" value="EKD00049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEM0"/>
    <dbReference type="HOGENOM" id="CLU_1262309_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEM0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="219" mass="23780" checksum="68FD291BE60C4043" modified="2012-11-28" version="1">MTSNGSSNGISALVASIGKGTYHDDSEAVCKVVKNLIDVVCLHEQARLRARENDSGRLNSTTLEDSPTDTETNLKPLGRSSADEPQIGHEARGDTVKPTATESHPACEGQDHAASLGTEASSKEVLADGTPHESVGPVKSKTKHEANKNRSKESKSQEDVDPDQARLQRLCRVEREEARMRAGLPPCESRPSELVKRLKKLRAFIKEQPGVEEYSSEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEV0</accession>
    <name>K1WEV0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEV0"/>
    <dbReference type="HOGENOM" id="CLU_377757_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEV0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="703" mass="79415" checksum="D314976318183DF5" modified="2012-11-28" version="1">MDAHRPLRRRPLRFPSFRIRFLPIFAGLSFAGLVIALGTLIYVSYDWVRVISDPYWLSYEQSYRWHTNGVRSLIHEGVRFDVGLSIFAVKPANGTERPECTEEKLAQWRSSRIGFTKADEGPDILRTSDRRLDDKPPCDSLYVAETNELWSGIVARDLTLADKTSESGIDFNIPPETLELLLKEPRQLIGVGPMSTLVYATVTLIPKVGVAVSNVEWYKDGMEDLPYVGDGLFAEATKSVPVKEGVKNATALRQTYLNSLSVRVPLVKTNFRGAFVATGVQATLLRQTNWIKRDVFEDRHAVLMHGACTSRARNWVKHRLLCAEERYETTGHWRAAYELETKTAKRRYSHLHYAPYLSYSGVGSMSHLQVPKSSQLKEFGHHNLKFRLAIVGHRRMGFLDHETVLNPQLGRDRAEDQRRHDGYEALHAVLGLRGWRAARLGGSHVLSVLSWVGWLMGRLLILLYWATRTTTTGISLWGTSLLVIGEALRSIAFTYDYYLETLPSWLFYVSIWGILLLPEVLQLRAILPTSLEKQGDTWTVADIPRTARERRSARLDIGPFYLAVLWVTLTAASYMVYGWPMRVLRASQDHFMRKQFEYPYLGEEVFSRMSLLPIAQATVTAGQIAQLVMNFRSKTFAGNYALTCACKVAALGGMAAPFVAGKAYHEGLYLGAVAQGFLVLAEAAQAAWYPRVEQEVEDDDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF50</accession>
    <name>K1WF50_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF50"/>
    <dbReference type="STRING" id="1220162.K1WF50"/>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024840_2_0_1"/>
    <dbReference type="InParanoid" id="K1WF50"/>
    <dbReference type="OMA" id="RYMALSI"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="210" mass="23068" checksum="FE2E642A94E575A9" modified="2012-11-28" version="1">MNMRELQKQALEPEVKKLGASISWGDDLTGVPEFDREPSFISRLLPASSDRFEKIPVGSRLEVSPESSKAVREMGKLIQNGGAGLVIDYGADRVFSDSMRIVDIFQNPGKCDLTANVDFAYLRESLEGVASAQGPITQAKFLLSLGLEPRLAKLISSARDEERRQRIRDGAMRLINTSGMGNQYQVMGIVPEKVAADVYPFPPASKVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WF55</accession>
    <name>K1WF55_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WF55"/>
    <dbReference type="HOGENOM" id="CLU_1679206_0_0_1"/>
    <dbReference type="InParanoid" id="K1WF55"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852841" evidence="1">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="157" mass="16760" checksum="12E5A6C49BD2BF71" modified="2012-11-28" version="1">MLAALLATVALAAPALAANHIKVQGAEFDLCIDNTDGKEVAGNPLQVWKCYTGSSNQAWNFSDTGKYPTTFKLGDSNLCMGVQQSPLADGAPVVLMDCAAGYDHTTWSAPNGRICLLGTNYCLQLDDDCAHDGTKLKVMTLSTSPSQLWDVKEPAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFS2</accession>
    <name>K1WFS2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Long-chain-fatty-acid-CoA-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFS2"/>
    <dbReference type="FunCoup" id="K1WFS2">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WFS2"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="InParanoid" id="K1WFS2"/>
    <dbReference type="OMA" id="KIFQWAA"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="102"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="683" mass="75308" checksum="17D311565501B8C1" modified="2012-11-28" version="1">MAPRKHHEFASWEVDADKPKPEGETRARRSYCTKELVLRPENGIDTVHDIMLYSARTHGSKKALGNRDIVDTINEEKEITRMVNGKEEKATKKWQYFKLSPLSWISYEEALEDTRNIGSGLRHFGLGGENETFFNVYAQTSRNWMLSAQAAAFNAVPICTAYDSLGPEGLRHSLNETEVRFMFTNAELLPTLAKVLPGAQTVKFVMYDGKADPAMIEKIQSIREGLQVVHIDDVRAAGKAHPAEAIPAKREDVYCCITAGTPKGVLLTHGNIVSAVGAIWLLLYEFLTPDDVYLAFLPLAHILEFVVEMSFFFCGLPIAYGRVKTLTDANVRDSKSDIMEARPSIMVGVPQVWEIIRKGIMSKVDAAGGLKKSIFNLAFKAKSAAQHYSLPLLGGISDAIVFNGVKAQTGGRLKIMFSGGGPVSRSTQQFLTTALVIMIQGYGLTEGTAMACILHPDWMQFGSVGGPTPAAEVKLVDTPEAGYFSTNDPPQGEIYLRGPSIFKGYYKRPDLDEEAFTKDGWFKTGDIGQWNKDGTLSIIDRIKNLVKLSGGEYIALEHLESVYKSVPFVANGAVIASPDHSKPAMVVMAHPQNLPAFCKKNNIGNGADLETLVKDPKVISACLRELNETGKKQGLKGMELLEAVVLTADEWTPESGFLTAAQKLQRKTIERHYHDDIDKVYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGN5</accession>
    <name>K1WGN5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGN5"/>
    <dbReference type="HOGENOM" id="CLU_1225531_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGN5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="24192" checksum="5598A3D5C80293E3" modified="2012-11-28" version="1">MAPIAAVHAVHAVHAMTGKIKTLKLTKSRLSAASIDKLAACAARARIRDIAMLLFGIGLGVLLYALLHDLVLAFFTREPPLECPPGCMCEPLPVYREKEEDEYSVPPGRPRGADKEDGAGEERWQGLRWLRAISHDVKPARLSGSVAGEGVSATEHYLLPEDSELVPIRSGVAASVQGLCKDKQEEGSGVTASQAERVRLAENNVALLCQSSTLTAVPTPLALKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHU8</accession>
    <name>K1WHU8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHU8"/>
    <dbReference type="HOGENOM" id="CLU_1696749_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHU8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="155" mass="16511" checksum="68935FD747DDEAEF" modified="2012-11-28" version="1">MGKVREWSRALQDPLQEQRERLISDTSNSKQKQAHPTPEHDEDEVGDEEEDWGEAEEGERDAELVRGRVDDPGPAGDARGNSGQPRQPVPHAQACKTAWGTGLGNCVLESSPSGSRIAPSSSTPNAAAVHPPLADIDEGGAVPSITARHLPSLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WI23</accession>
    <name>K1WI23_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WI23"/>
    <dbReference type="HOGENOM" id="CLU_740077_0_0_1"/>
    <dbReference type="InParanoid" id="K1WI23"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="374" mass="41328" checksum="B7EEFDCE20ADF3C5" modified="2012-11-28" version="1">MELADEKGVSGTAVKRKSAGEHAKQPKRQLLGTTSLPPPGTTPTPSPRTPANSTSSSSSAELDILRSQLHAAKAKARAYKERNEELAHRAEEANRLAADAEDQRLDAVSRAEDAEERAETAKSEAEMEVAELKDELDKAERDACAAEDRVEDLEERLEAVERDAQRRIADATTQAANSEAMVTTLKLLLQATEQQVQTLEGIVARVAGVLQDAPKDLSTATFAETEVTTTDPDITTHHTLAIPRHSINRRDTLREQWEKVHDLIQDVYSEVENNLWNTPMGDSSDEQSDDSDDTVYSSLGEKKSDAKQRTRQASMWMERADALLDLDKVYKSQLKDFAGPGKSGDQMADRFAKNLQELQKQAEALRKEVAQGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIV1</accession>
    <name>K1WIV1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIV1"/>
    <dbReference type="STRING" id="1220162.K1WIV1"/>
    <dbReference type="eggNOG" id="ENOG502RZ9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIV1"/>
    <dbReference type="OMA" id="KRCKPRS"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852958" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="193"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="439" mass="49021" checksum="B3715E717629EA82" modified="2012-11-28" version="1">MFANLATVLPYLALAGLALEATPVAAKHQGGVQRRAAHARHVKQVERNYNAHLPRSSKVKRDAPQISTLPDGRKCKVRPSPAAPSLSQPTSTQSADQQQQGQDQQQQDQSQQQQGQDQQQGQDQQQGQDQQQQQDQGQQQQELQQSASAEAPPQASAAPPQIGSTSTGCATAGWKNTGSKLGIAWPNGDYWGPNDQQYITNYIGSKSSWYYTWSSYRVRSADEAGLEFVPMLWGKDKIDDGSWDENCNKNFDGALVANALFFNEPNQHDQSAISPEDSVWIWIEKFLPLRNNKGIKLGGAAPTSAPDGVEWVKRFHQACVEQGHADWECTADFAPVHYYDVDVEHFKQYLINFHNQVNKPLWVTEYACQNFNNGAQCDDGAIWYMHSEMSKWMDQQDWIQRYAPFGVMQNMQNVNPNNALMSSNGYITPLGSSYASGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WLE3</accession>
    <name>K1WLE3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="14">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_03611</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WLE3"/>
    <dbReference type="FunCoup" id="K1WLE3">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WLE3"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_11_1_1"/>
    <dbReference type="InParanoid" id="K1WLE3"/>
    <dbReference type="OMA" id="EMADQFV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="567"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="571"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKD02059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="638" mass="70804" checksum="044102F53F22D740" modified="2012-11-28" version="1">MMNRRDERDPKKKQQGGKKEDDFQQPKLPTAAELYVESLPGIPNMAAHPTHPLNVYAGEIPSYPGPGKGGGDGQVGVDADIFFLMVRARRQAGKQRVIFWFNGGPGCSSFDGALMEVGPFRTVPDKDTVSRLVEVKITEGGWEEYATIVFVDQPPGTGLSYVPAGGYLTELTEAGQHFVQFLKNLYQIFPDLENQDYIPYIADAILNADLPKMHLKGLAIGNGWVDPLNQYPAYAEFAYQKGLIKKGTPEGKELDLAVGSCVETMKQYEDPLKTPVHIDGCESVVMSRVTDPVDGQKMCMNIYDVRLVDTWPECGMNWPPDVSDVQSFLRRPDVVKALHATKHEQPYRECNGQVSVRLRNRNSPASVHLLPSILERGVKIMMFAGAEDLICNHVGVERTIENLVWLGERGWGANTTTLPWSMNGTQVGEWTEDRNMTYVKVNGASHMVGFDVPAVTNDMIMRFMGVDIKELGGPTGEVDSKVGDDERPALHYGAYPETVGIPLLKGGKSDWESWYNAISAVLILLTLFGIVGAYLYLRRRRLRRQLAARGGRVSSLEDEEERVPLATYDGETYRDENGRVDRKGKGKARESFDEEVSEHVLAHSRRESRGSAHSSSRRGSGSGSQTVFALGDEEEDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMA6</accession>
    <name>K1WMA6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMA6"/>
    <dbReference type="HOGENOM" id="CLU_1679202_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMA6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="157" mass="16712" checksum="C871CCCBB129838E" modified="2012-11-28" version="1">MPFGTLVIDGGAGGITAESTRGMDEYRRNGVLRCEAEIPSEGLGANRDGLGDGDRRSGTASRRPVSGVSDDSARWPAKARGRLIDHAPKPPGMCSAAQHSATCVDQVDKRMGQARQKRAGCCPDTDASGRPGIAARVVACRQIARHALARFRKWTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMJ6</accession>
    <name>K1WMJ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMJ6"/>
    <dbReference type="HOGENOM" id="CLU_772055_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMJ6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="41026" checksum="0A26919B2ADF387D" modified="2012-11-28" version="1">MRPSVFGSIDTVTCRSWTARLPLEIITKVLEDVPQETLFSTLTVNRDFSKAALPLLYRHLYFQPKRTSKRGKISPEHLRHVKMLDIFDHDLKHCEKLEFSHSPDVVRFHWNDSIEKLHKWHGDDKPCPLLSLKPKSVVFVDFDATKAPPDAKAFKNVIYPHTENRVVMWDISEELDNKGWNAAVKNVIFPPEKDDTGFESRIKAIKKGKGGEPRPDDLTRREIVVFANNTTNRHAGFGFLWWFKSFAKEHCRRKHIVVNMGAYRPRDAHYIDSLEEELWKYCANKSEESDLPDDDEDPDKYDNLHLLSINTWERIEDCRPMLLEYLTESEIHNLLPPPKEPKASTKKGKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNE9</accession>
    <name>K1WNE9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial outer membrane protein OM14 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNE9"/>
    <dbReference type="STRING" id="1220162.K1WNE9"/>
    <dbReference type="eggNOG" id="ENOG502SCDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634892_0_0_1"/>
    <dbReference type="InParanoid" id="K1WNE9"/>
    <dbReference type="OMA" id="SDPKQWG"/>
    <dbReference type="OrthoDB" id="2553651at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46492" checksum="3251F681AE6C0702" modified="2012-11-28" version="1">MSYAKATKSHIPEGEMPEPSQELLDGSTSSLDDAGNEAAGAKKNVQQASGKARATLAEDQAAEAEIKELTAAEKLAAEDVKGSLRKAKQDVDATTKSSKPVDKNFGKQVESDAKAAAEQAKKDASKAAQQVGETYDKVKKDADKAAKELGEKYDAAKKDAKKQLDNAADQAGKAYNAAADQAGKAYNAAKQDAESKYNAAAEVAERTYNSAAESARETYEDVSEATKKATAEAQKQLDASAKEAKRKYKEYKKKAQQEWDEAENAFAAYWEKGKDVVLRPSTLGGLLGIVNVGLLGGLGYTAYKNKDNRPWDPQVVGGAIAGTLALFGAEGYLAESYLETEEGRAEAERAKREGSRLYLEAKKRILRPDVAGGIMGLVNLTILASLGYVSYKNWNQPWDRRVVAGVAAGLFALTNVEGYVAEQTLEREKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQH2</accession>
    <name>K1WQH2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQH2"/>
    <dbReference type="STRING" id="1220162.K1WQH2"/>
    <dbReference type="eggNOG" id="KOG3112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062640_2_2_1"/>
    <dbReference type="InParanoid" id="K1WQH2"/>
    <dbReference type="OMA" id="WKEHTGE"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="302" mass="31518" checksum="CD3FAFFA65D3B0BF" modified="2012-11-28" version="1">MTPASRVVVAINLSPTMSTGPIYPVNGLDTSKLKDTVLVVPSVSLGNVPQLAGDLLVSSLGLKRVAFVGTGETVAPFAGYDSEAGILTGGLERKLLYWSPSKLTSVYGDQGSVYVLLQRSPTLKVRTDGSNDLTAYGELTLQTKKDEHVALIAAAGKAFGSVLVLASLDAANQDDAQLLLAIVRDASTTILERLAQLPALNLRLEGAPPREQQKEGVYPPFLPGAGLTRRTLAALKEQGTPAGALAAWVVEGDNRGDAHALAARTLDLAGIEAQLREPSSWKGLFGGEGWSGGAGMDAEIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQJ0</accession>
    <name>K1WQJ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQJ0"/>
    <dbReference type="STRING" id="1220162.K1WQJ0"/>
    <dbReference type="eggNOG" id="ENOG502RBCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372210_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQJ0"/>
    <dbReference type="OMA" id="YYYPEQY"/>
    <dbReference type="OrthoDB" id="10680801at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="79040" checksum="B6D47441E4832C83" modified="2012-11-28" version="1">MTDAAPETSSPAAPTPAAAAASTSTTPKTTAPKRKTKSRRKTRRRDGSDSDASSDGSVSDAAANAAPKSAKGKGKAKQKPLFPESSHTTPLVWADADVSQNEIVSFDFGDSSSKSTKPAAPAPGKPQREFTEEQRKRHEEKLRIKKEKQKAKRRAAKEAKAKEKEAAAVKDSKPKDDAEKTDAASKAPQPSKEDASLAASTSALKLDDPAPAPASVPTSTPASAPSTSPPTAAATATTTPAVRPNQPFAPHRPLRERLSNPPEGRFAPRPPHWANDQRQPVRPMPDFWRGRGGPRGIPRGAFRGFPRGRGRGGFGPFGPGGPHFRPPFRPQGPPHGPPNAVNAAVANNASSTPPANAPSAPRAMIDSSAASGSGTTPASEQPETTETAKATEPESADKPQPTPAQPQQQQPAQPQQPVVPPQRFRPNMPRPDGRWGHDGFHQHMREDAFRANRGMRARGRGRGFAPRGGFRPFFNHPGHLPTPEVSPDRAEKPAATAAAPAAPAAKPTESASIEALLDDSGAVTVRLPGETETVAVDPVPVDTRPPSQPTDLVSQSPLPPAFTPSNPSPGPYSDAGSMSSSGYVGPIPAEYYGGVAFRPPPYRGFQSFTPEPFQPGHASHPSHASRGSFSGFFSGSPMDPRAGSPFNPYAPGFVMPTAVGKDVTGEPKSPHSEGTDSMPGQIQTPEFAMAPYYYNPYAEQPMGQMGQMGGMGGVFYPPPQGYWPQQYEQGMYAGFEGEYQNQQGHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQK5</accession>
    <name>K1WQK5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQK5"/>
    <dbReference type="HOGENOM" id="CLU_909696_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQK5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="306" mass="33326" checksum="8598A3C0A4C0D4E4" modified="2012-11-28" version="1">MALPLCYSERELRLHRRNRRRAELEQPILSPGAGPAPPPATGATPQGSHPYRRPSRSSATPTPDLGTRAALEAVADLQDEAQGSASKLHPKGEDKAGDAVAVAGEASLSDAESTSVTSGAGDEPTSELEQDNGAISSARQRIDYLALAAGEKTVNIRLRTAKWEYTADEATVRRLNTRRHGPGAKVIKRICLPMPRRAVRKVAAGKKTVSLRLRILVPPDTPFPSSDQVFVRAYPQNEAPFTFGREDLEGKQKEEWDDWVGWVDSVRSDRLGHTTSTSRRPELDPASAAAPEQPSTRPRFSFSKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRD4</accession>
    <name>K1WRD4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRD4"/>
    <dbReference type="eggNOG" id="ENOG502TM10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246546_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRD4"/>
    <dbReference type="OMA" id="IGRCTHI"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1069"/>
        </location>
    </feature>
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        <location>
            <begin position="1112"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1225"/>
        </location>
    </feature>
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        <location>
            <begin position="1245"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1547" mass="162911" checksum="BF9CC1636BAD0865" modified="2012-11-28" version="1">MAGGKRKRTSSPGPAATPEADPTRGSKKSKSSDARDKDGDRKVKIVYELVGTNKTYSRDADSRSLDKVATKVASRLGVPFLGLQMFHARAARNKSKREVIRVYAAGSKAPSSSSAPVTAASTPELPRRATSVPTALATPRSALRLPGNNTPRSEKRVVLALPADSPPDSPSPAPTVTPAPASPSVHPSKTRRRRVRGRASLESNENEQPQTENATAPAASRSTLSTPPNATNEARRLEIARQEIAKREAASIAKRDAATLFRPANPSPLSQATTADTSDEEPPAKKKKESKAAASPAKKATPTKSPATKKSEAAAKKRADKPTRRQSRTSDLPLVYGDIPPVVGSLPTTVAETTQPAENTPTATTASPITASGSTPTTPKGSGAARPATPLTKTQLEIRALRQRQAEEAARKAAASESAGTPSGQDTAGAGTSDQSSRPTEPAVEAEIPPKGRPGRPRKSDSVAAQGQETATSDVGTAPAPSTDAPSAEEVTPKTAAQRRKEEAQQRKKEKEEAQAKKKAEAAAKREAREKAREEARAQKEAERREKAAAKASKAAETVKQTRSQKAKAASPVQDSELESEEGQSTTDTAEKVDDAEDDSGIDAVAVEATEVEVEESRHSTPSQDGADASEAPNAPGPSAVAEEQASAQKPPSGKKRQSSSGKELCIYCGQVGLHKLLKDCPIANDKAALLNRMEERKADLAKWRREAKETGGNPADYSEASDLVLKQVRSRYHSADQTISAKVNGVHKPLAELGPSKYPTSASEPITLADDDEPGEASAAESGAPAAEAVAEVADMTVESPESSGSSEADEAMDVDVVEVAGDEEANETPKQAPVKSVVGNAMARASPRAPMTPQREAGAESSSSGSSRSSPSESGEGGTPFLPQMLQMKAARARRPGSRLSVSDAVIETGDSDSDDSDNSGSDSDSDSDSATTSDSDSSSSAAASDYDGQVLARQVMNGPLNKRQRHRVSVSAPGIHETQALSDEDIASADEEDDIIPRRLTQRRDSESSIGEFEEDNNSPAPSDVEESDEDDERRRTLLSAVADRSMAIDDDQEDAVETDSDEETPAADIANRSFTRLAERAGTSPALDDLPGDQALREVIQEDDGMEFTQNSAKESAEFSATQPIEMESVEPESAEPEPQPTSSSQAKRRPGRPAKAASQPEPSSSKSKTPEEAESPEPSASQPLRRTTRGAAAKAKEPPASQPAPGGRVTRSSARVVSSSQPVTRRTTRSSSKEPEAAPVSSSKAPTSQDIAEEDSDAEPEETPRSKKKVVTYSRSSRSKQKAPEVDGNDSDEEDNAANEEVLVEPTPAQPVPSSLPPSSLPQSNGVPSSQPPVSSQPGRTQSSPTKQNGEGSPLFLSQPTQLPQTQAYNPHPEPLVPETQAPDSGPARLSSPVPRSSPSPSPSERGSPQPNGRANGKAVMNGDDSEDDGSDQDVDYAPPISLSLSRRSTGPPMPATAFPTLSSLPKELLRQGKDATVGYISRITKGSTIGGGLPSATQQHDDSDSSDDDVDSSEDEIPEERQERYAGRKKRRSTIGQQIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1WS01</accession>
    <name>K1WS01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_01787</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WS01"/>
    <dbReference type="FunCoup" id="K1WS01">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WS01"/>
    <dbReference type="eggNOG" id="KOG0635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_1_0_1"/>
    <dbReference type="InParanoid" id="K1WS01"/>
    <dbReference type="OMA" id="HENTVEE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD03774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="208" mass="22769" checksum="3902D63464160AAB" modified="2012-11-28" version="1">MTATKATNITFHPGAVTQEERAQLLGQQGATVWFTGLSASGKSTIATALEQALLNKKLHSFRLDGDNVRFGLNKDLGFDPASRVENIRRIGEVSLLFASSCSLALTAFISPYIADRELARELHAKHNPPLPFIEVFVDAPISVVEQRDPKGLYKKARAGEIKEFTGISAPYEAPENPEIHIKTDEVDVTQAVEKVIAYLEEKGIIPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTD0</accession>
    <name>K1WTD0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTD0"/>
    <dbReference type="HOGENOM" id="CLU_1361281_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTD0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="201" mass="21815" checksum="F2810F2BD5128056" modified="2012-11-28" version="1">MMITRSVVTQFVEESKESEPSTKALRCRSVRDDRGLRCRAPASPVAANHAANGGVEDVLRLTLGRYTHSITYLLASHGATCSALPDLSSCALRPSRAASWMLPKRSADGKRSIPSAASPYWLLAPVNFHQRAAGLLRLYSSLSNRKPALVTNILLTLHEEQLKLPADAERVPDTVQALLRTVFSSSTGHFDSPQSPSLAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTQ9</accession>
    <name>K1WTQ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">von Willebrand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000228">
        <property type="protein sequence ID" value="EKD04274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTQ9"/>
    <dbReference type="STRING" id="1220162.K1WTQ9"/>
    <dbReference type="eggNOG" id="ENOG502QRPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003826_2_0_1"/>
    <dbReference type="InParanoid" id="K1WTQ9"/>
    <dbReference type="OMA" id="QRAIMTT"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="283"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="999" mass="106222" checksum="DF09FF688AA0878A" modified="2012-11-28" version="1">MAYGRTVLNVACFYTIAAETHHLPQVAVKAHSTILSTTSRTTLTQTFSNANNYIIEEATYVFPLYEGVSVVRFKATVGERVIEGVVKEREEAKQEYEAAKDAGFTAALMEQTLEAADVFTTKIGNIPPKSTFQVDIEFIGELKQDLQTEGIRFTLPAELYPRYGNAQVEESDFDQNKSGFEATVDIQLPEGITIKTVQSPSHPIDVSIGNLSTDQDAAPSFSRASATLSKKETNLDTDLVIVITPSKTGDPTALLETHATLPNQRALMTSLVPKFTLPAETPEIIFVCDRSGSMQSNIPDLKRALNIFLKSLPQGVAFNICSFGSRFSFLWPKSRLYDQKSVDEATRHVATFDANYGGTEMYRPLEATFKQRLHHGYNLEVFLLTDGEIWDEENVFRLINEASEKGNGDLRVFSLGIGSGASTSLVEGVARAGNGFAQFVADGENMDKKVVRMLKASLFPHINNFKLEIDYEGAGGESDDFELIDAASTVVDFESEKSEKPKKATISLFDTSAKIDDAPPPEVKPLPTFAEQPYLQTPSSIPPLFPGSRSTVYVLLNEGAPHKNIKSVALTAPSKYGELRLEIPVTDVGRGTTLHQLAARKECRELEEGRGFISRAPDADGKTGAARFGPVWDKIIQREAVHLGLRYQVANKWCSFVAIEKMPDGTEFKAGSTHEKAEGSLYSDGYPLGSARGGAAGGGIRKAKAAKGFGFGGLSFRSKSLVVGSAPPPPPAPAPAARFTPSAAPAPAARFTPSAVDAICTRGYEMPAQSQPVLFGAAAAPPAPKPSLFGGGGGLFGQRSGGGLFGGFGSKGSSSKGSAFESSAPMQASDALFGAAPPPALAPQPTGASPALFGRSASPPGSTKRVGIQSSSPPVAAAPPAASAFTFGSFAPQAEAAEVSAPSSSPLETLTALQRFDGSWGWTADLERITGVTFEDAKSAAPSIADDALPTALAIAYFRAKLADDADVWELMVGKAEAWLASKVINAEVAVEAVAKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTY1</accession>
    <name>K1WTY1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTY1"/>
    <dbReference type="HOGENOM" id="CLU_1490023_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTY1"/>
    <dbReference type="OrthoDB" id="2563136at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22042" checksum="1F7851EBE6A05FB2" modified="2012-11-28" version="1">MPLDTSATDQLSAPDSRNDVPAEDPVPLLDAADGTTKPEPKLKSREDLRRLNRRATQDGMYGGMLGGGALTALLAHRFGMPKNGLVITFLLSSTGISFLTTRHMIRSALGEHYDYIQSRQEATGGMRDRADGDSPLAPVSPLAPVDTEAERRRKLAEELSNLGKPRPRTMFTKGKGLEGEVEEQQEMVDPYLRSGVPRREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWG6</accession>
    <name>K1WWG6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWG6"/>
    <dbReference type="STRING" id="1220162.K1WWG6"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011334_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWG6"/>
    <dbReference type="OMA" id="SYESWPH"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="698"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="620"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1025" mass="116429" checksum="528D45AA8D536466" modified="2012-11-28" version="1">MSDYRRNWDSGNGDSSRNRGQGGWNIKRESSWRPNKRGKKQWNNGGAGGDRGDRWTGASQERRWGNDRNDRNDRDRSDRDDDRSWRNQDDDGWKRSSDRTADNNERDYDRDRERDRPSTSAWKGSSPDERKDYYEPLSSRPIQSRTSQHSASSQASQATQDRARKTGRPNRWDQREPPKRKERRWGDRSSSRGRDDSPRGRSDSESEDDRRRYRSPSLEGKRRAYSPARGPSKRARDTSLSPRSPSRGRSLTRSPLSRSPSPRRNGRSPSPSRRWSTSPKRRSLSPRRRSPSPRRHSPSPRRRSPSSPKRLSPVNRKRSVSPRKRSTSPRKRANKWDQQRWQPPTGPRQQREWGKAQQPFAQVSDGPVKMRQWGKPASPSRSPTRSPSPSGSRRRESPPPPRRWGGESPVQRGQSPSRQQRMHVDTPPRQPNVPPTGPRGFRRTPPREPGALRLPPTGPRSERSPYPAFNGGPQRSPRPGWRPIASEGPGIEAEAPEVEMDVDEEPGQRRADKWSPTKWAPVKDQGSSLLRPEAYLDRMAAKEQQYDQHMRNVSPYIKQAFAQWYAQNATPSLPEFLNHYFGRAPNQVELDQIQQLLSVRSQHDQDQKDLRDLHAQALLREKDSLRKAPPTGPRSERLQTGSSGSTPGPPGDRPPPPGPAGRGLAPPTGSSGSTPGPPGVPGAVARSSRSRVAPGEAYERLAQVGEGTYGKVYKARRVEDGALVALKRIRMEQEKDGFPVTSMREIKLLQALRHENVVRLSEMMVSKGSVYMVLEYMNHDLTGILSHPEVKLSPANIKSLNYQMLAGLGYLHRRGILHRDMKGSNILLNGDGELKLADFGLARFYNKHKRMDYTNRVITLWYRSPELLMGETAYGPEVDMWSAGCIMLEIFTSKPAFQGSDEISQLEVIYGILGTPDEASWPGIKELPWYELVKPKDVVPSRFRQSFGSLNLSEGSIEVVEQLLKFDPKQRVSADSALQMAYFTTEEPRMEPPTQLALCGEHHEMSVKQGRYRMKQQSQHSQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0J4</accession>
    <name>K1V0J4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_08196</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0J4"/>
    <dbReference type="FunCoup" id="K1V0J4">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V0J4"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="InParanoid" id="K1V0J4"/>
    <dbReference type="OMA" id="KKQGMLG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="64"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="580"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="677"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="797" mass="85707" checksum="C066B414FCCB62D0" modified="2012-11-28" version="1">MITPRATASILRGARTYATVGGRIGETKVPMSNLEKGKFVNYQRIEDNLAVVRDRLQRPLTLAEKIVYGHLDNPHDAELERGVSYLKLRPDRVACQDATAQMAILQFMSAGLPETAVPTSVHCDHLIQAQVGGAKDLARAVDLNKEVYDFLATACAKYGIGFWKPGSGIIHQIILENYALPGLMMIGTDSHTPNAGGLGMVACGVGGADAVDVMSGLPWELKAPKVIGVHLDGQMSGWTTPKDIILKVAGILTVKGGTGAIIEYTGPGVETLSATGMATICNMGAEIGATTSLFPYNDSMARYLQATERSEQAKYAQAFKNNLTPDQGAEYDQHITINLSELEPHINGPFTPDLATPISKFAEEAKKNGWPEELKVGLIGSCTNSSYEDMSRANEIAKQALDAGIKAKSAFTITPGSEQVRATIARDGFIDTLEGVGGVVLANACGPCIGQWDRRDVKKGEKNSIISSYNRNFTGRNDANPATHAFVASPDMVTAMIFGGSLSFNPLTDSIKGPDGKEFKFQAPKGQELPVKGYDKGEETFQAPPADGSKVEVKISPTSDRLQVLKPFAPWDGKDIVDAPVLIKAKGKCTTDHISAGGPWLKYRGHLENISQNCLIGAINADSGEANSVLNQVTGEFGAVPTVGAYYRDHGIPWVVIGDERLPQAALIPRQGKADIEDYGEGSSREHAALEPRFLGGRAVISRSFARIHETNLKKQGMLPLWFANPADYDLITGSDKLTIHDLASLAPNKPVKITGKRADGSEYEFEVNHTFNEGQISWFRAGSALNLMKEQAAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1J0</accession>
    <name>K1V1J0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000402">
        <property type="protein sequence ID" value="EKC97799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1J0"/>
    <dbReference type="STRING" id="1220162.K1V1J0"/>
    <dbReference type="eggNOG" id="KOG4328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017019_1_0_1"/>
    <dbReference type="InParanoid" id="K1V1J0"/>
    <dbReference type="OMA" id="DPNTLYW"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="553" mass="62358" checksum="E958F1D44F6E3378" modified="2012-11-28" version="1">MDMPKKPPKAKAASNPRKRKAPTEEEPRATRRSGRIAGVKADPVKLEEFRQEEARVREEQRVKDRRLREQVMTVGEQMEEDSAPVEQLVELLKNMPVCERPDAKSVKDAYPEKEGDKELERLKEQFKGMHLAANKKVTTERVYTMLVHPDPTKNLVLVGDKYGQLGIWDAPTGEAADAKEETKPDVKKEEGEEAQEEDEDGRVWRMQAHAKNSISCMKVDPVNGQSLVTSSYDCTLRRLDFSTGVSTEVFAFEDEDNLINHFDLVPTGQEAWLVDKNGGISHADFREKGERRRWEVQEAGRGAKLGGCSVNRESCGPHSTTSLSYQTRPEANRPALMPHLLVTAGNDQHVRIWDTRHLKKLSPKSVETILPPKQEEGKEYIDTHCESSIPYERMQGYMESKSGKGLLRASYQHGKSCSAAYWDPFGRRILTTSYDDKLRVFNVNPQQLMFDTPLPASQFKPTKAIAHNCQTGRWLTILRAQWSQNTEFTPHFSVGNMKRRLDVFSSGGERIVSLWNEAVTAVPAVTAAHPAHVNRLVGGNTSGRIQLWTSGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4H7</accession>
    <name>K1V4H7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4H7"/>
    <dbReference type="STRING" id="1220162.K1V4H7"/>
    <dbReference type="eggNOG" id="KOG3148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_0_1_1"/>
    <dbReference type="InParanoid" id="K1V4H7"/>
    <dbReference type="OMA" id="HVITQGI"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="31878" checksum="FD4F870B545AD74D" modified="2012-11-28" version="1">MRLTIRDTKEEVGSHIADYIVRRINKFVPTEEHPNFVLGLPTGSSPLPVYRRLVELYKEGKVSFKDVITFNMDEYVGIPRDHPESYHTFMFKNFFSLIDIDPKNTHILDGNAEDLYAECEQYEIEIKKVGGIDLFLGGIGADGHIAFNEPGSSLKSRTRIKTLAYETIIDNCRFFNNDLAAVPRMALTVGVATVMDAKEVVLIVTGANKALALSQMIEGGVCHMVTASALQSHPWALVVCDEDATAELRVKTVKYFKSIEKVQNEVEAKYGEQGSWRMGVAKPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1V568</accession>
    <name>K1V568_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V568"/>
    <dbReference type="STRING" id="1220162.K1V568"/>
    <dbReference type="eggNOG" id="KOG3186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1391120_0_0_1"/>
    <dbReference type="InParanoid" id="K1V568"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21336" checksum="3FA931EE113BA52C" modified="2012-11-28" version="1">MSRSEPGVSFKGSFDSARGDAAHAPSRHPEVRSYIANVVQGLSKDLELGLLRRVTVVIKAMDGLPLERFIIDFGFMQMDALDGGNRDAKIIGAPSAFDLDLLLRGFLVRLVALDSQLLDLRGETTWTIVAETHDGREPTFKGDGSVPLWTPALAQDTLHPGRDGHDDDEQHEPLLSVRAVETGVIDSVQPRPDESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5E8</accession>
    <name>K1V5E8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5E8"/>
    <dbReference type="STRING" id="1220162.K1V5E8"/>
    <dbReference type="HOGENOM" id="CLU_009095_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5E8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120740" checksum="FFA446D8C0325066" modified="2012-11-28" version="1">MPTSTVDGAGLTGTFPQRLRAVGHYARQQAPDEQDALIKKLEAGSPQDQYLAGLAAVATQNKAWIAKHVTDKTPGLQHLALRYSHLVADSVIEDALAGDPSDFTRKALVRHGLSGRPQLADKLFPILRNAWGDHFAIRVLAHCSPSVVERHLPQLLPSASVTSLWTLLANKHAGILMAALKNSLDDAAEFGILPSTWWGEFGVAVTALLKVDPTFAPSVLDMVDKHKLAAFPHVLNSQLNTFARQDPSRMLEYLSRPNWLPGRTLPRRAMRRIARPATGTPALIKYAETFIGRAWGWDDLLQALRPRDRLPIYEAMKIDGTACLDYLPRQDQIRLATSMVQKNKRVPVSRSDELSAVSYLEPSEAAPALEEFMMNPDMEIRRHAIQCYVKNAARARSPDVWDAALEKLSTRLRNQPQPVREPVINTICDVSPLTWTTNSLPFIRKIAQDALDTPDMSSVVSTLISYALNTMRERPEFEAWCLELLQAINKMGPVYLSEKVRHGQVLKVVQALEPDLKGGLKKKNFNPIYTVANWTGKRLKDIPELQHMLQDITVHVGAVRYNVMEALQLLVDVDKSYAVKAVQDERSTLEFKSVANVIARYYPELLDLGNPPKGRWLEDTTDWTFPCDAYLSKFWPEDQVAIYLEQLKRDVETGNTWNRAMRLRKLKHVPGGISTAKEYTQDKNTRIAEAALSVLASDPKELPTLLSYASTDSARVAMYCAGRAAKHVSTTELQPMLIGVLKGEKTKITSKKEVLRLIARLLPVEVASGILSEMASAPNAHRDVITAAAIAASDFLQSSPAGRVIVEETAAKNKETSMAIAKRSPLLVNDRARYAKLVTSLAKAEDDDVASAVLGNLGNWASFDPFAWTILKEAITNMNRRKVWKSAVQALTGRASDPKGQETLCETIAELLAMKEKPEDNAGEDSDLPVFRRVQDIAQRLWSLTRALPSKYGQATRAVLKVIDNSGSRDYEEEYCDLLLSLWKLDHRVLDIAIARLDGRPILAQRFAETMRNWLQPSEALPVATKLASGGYTGALFAVALAGRMGPKSRWEKEWKDVVKTLRGHDSPEIRDLARHIKAVQQDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1V667</accession>
    <name>K1V667_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V667"/>
    <dbReference type="STRING" id="1220162.K1V667"/>
    <dbReference type="HOGENOM" id="CLU_132741_0_0_1"/>
    <dbReference type="InParanoid" id="K1V667"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12203" checksum="093DDB9AFBF71825" modified="2012-11-28" version="1">MLSEELSTDMDNSGASAGAALSSISSRPPQQQVPSAIETFVADIVRRAKDVETLIAALPSKNDSAGRAEMAQANAEYKDALAEAEALLGELRDTLKVTLGDGTERNVPSLKNAVAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6Y9</accession>
    <name>K1V6Y9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6Y9"/>
    <dbReference type="FunCoup" id="K1V6Y9">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V6Y9"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="InParanoid" id="K1V6Y9"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="212" mass="22280" checksum="D0C97A78C6E1FA07" modified="2012-11-28" version="1">MADQTIKGPAPQVHDGSKLRIGIIHARWNDEVIKALVDGTLAQLKKAGVKEENIVLKSVPGSYELPFACQNRLIEGGKTQASGANSLISTTNLLSLVEGEGTGGTSTPAGDKAGAANKQPFDAVIAIGVLIKGSTMHFEYICDAVSQGLMRVQLDSGTPVIFGVLTCLNDDQALERAGIGRKGNKGHNHGEDWGLAAVEMAKATQEWAKGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V754</accession>
    <name>K1V754_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V754"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="K1V754"/>
    <dbReference type="OMA" id="TAVAGHW"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="230"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="424" mass="45612" checksum="F779C53B9FFC7873" modified="2012-11-28" version="1">MSESDMTMAVTPSEKEFKEIERLDSRHSREPVILGNVAIDRNSLDAAAFTSAGQLLPYYSTHFLPGYSKAQVAWIGSVQPLMVFSPAVLTGRFFDVHGARIQSVSGTLIAFGAIVALSFSKEYYQLLLSHLCFGIAGGLVYAPSTAVAGHWFLKRRSTAVGIIVGGSGLGGVIYPICMKVMLDKLSFRNTMLIIAGCNLVLMAPGCVWMKARLPPKTPPPWRTLLKPWHDLRFVFLVLSCSTYGFGLLTGYFNAPTLATGNKLSPNLIAYSVAILQAGSFVGRIAYGMFADRFGVGPTFGSLAFSTSVTYYAFWTPNTGPVGTCFGLVLFGIFSGAWFTLAASATAHISPPEELGSRIGMMWTSIAIPVLLGPVISGYLVSAAGESRFTYAGIFAGSTMLISGLLYVAPHLWRLVRRSKESNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7H4</accession>
    <name>K1V7H4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7H4"/>
    <dbReference type="FunCoup" id="K1V7H4">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V7H4"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038617_1_1_1"/>
    <dbReference type="InParanoid" id="K1V7H4"/>
    <dbReference type="OMA" id="FINEHAG"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="80"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="351" mass="38185" checksum="DC5E98E0DE13479C" modified="2012-11-28" version="1">MCKKLAPVYEQLADVFPSSKVIIAKTDADGPAKDLGNRYGIRGYPTLKWFPAGSLEGEDYSGGRDLESLVKFVTQKSGVKSTLKPPPPGAAVELTAENFDDVVNGARNVLVAFTAPWCGHCKNMKPAYEAVARAFKDEEDVVVALMNADDDANRPIAQRFEVKSFPTIKFFPKDWTFPMAYSSGRSAEQFANFLNEHCGTQRSATGLLNDVAGTVGELNDLAAAYIASIPSREEAYEKAKAYVSNLTSSASDAASGVSDEASKKARVAAEYYVRAMERIKSKGDAWLDKEKNRLAGLLSSQSMAGKKLDELKVKINILNAFVAKKIDEITADDEDGDVVEVDEQVVLKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA82</accession>
    <name>K1VA82_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_08084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA82"/>
    <dbReference type="STRING" id="1220162.K1VA82"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295287_0_0_1"/>
    <dbReference type="InParanoid" id="K1VA82"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="685"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112953" checksum="B88ECF5777E9DB5B" modified="2012-11-28" version="1">MEVEKSYMPTEKDLRRMTATHLKRLFATQDVFGAGDKNVASTPVPELDEKEKSTEGEATETATTAGGSTEVASVTDTAPSSAHATPALEPATHTPPVDSPMALETSSPLDRAAAPNESVTPTPTLSRGNSAKLELTATPIADRIAHSYDSDSTVSAIKRSPLARSPQRSYLYESSGIDSDTLGPPRYPSRLPRRAHPTPSVSDLVRRFQESIHDTDMLSPDAPPVHRGLRRIESEVSDSDVALPSRPKLRRNPPSRHREQKSLTSDGDRSYAVNAARIPSSAGRTRTRGTSSRATSPAPSRGRSERSTSKSLSKAPSQDGKPRLQGKGKMTRKVNEAPSPVMRMPRRVIGAGSRVTSIARHFDKISREAERDRQKRISMARGKRAGRVGVTRAKVQVFNNVRDAFKDEFDSDSSAADNEEDDVVSDVSIDSTGRAKPRRKATPTKARPVVFPHTRVKVPKDLKGKGRAKTEPGPIAAEETPGRPGMQRSETSPVDPTDATTSTIESSHREGSTEDSTLVNSSNGDSTLVDSTVAQEGRSPEATPTEGTRSGADTPALSDVEGLLKDRLHIELAPFDTNAPLTNASQPPTPAPFSEKEAEDHRPFSQMSQVSESEMSSGGGERSSILKSLTGLWAYRAGDFTPLEYPLSAAEHIFADSRVIVRESEPTSIIAFTVSSKQYRDQMRAVSAVNKASARRHEPSLLDEMTGGERPWDIISVDEAIDPAEEPRREAGTHLKYDFEAGSSTISCRIFFAEQFAQLRQSCQCEDIFVESLSRCAKFDASGGKSGSAFLKTKDDRFIVKEISRFEMDAITKFAPAYFEYTQTAFKRGRPTALAKTYGIFKIGYRNAVTGRTMHMNVLVQENLFYARTFTRIYDLKGSTRNRLLKPTGKPNEVLLDENLLEVSHTHPLYLRDHSKRILRTALWNDTLFLSNLNVMDYSLVVGIDQERRELVIGIVDYIRTFTWDKKVESWVKDFGGGGKGEPTIVTPLQYRKRFRTAMDRVYFPAVPDRWTDPEDEQGGGEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB07</accession>
    <name>K1VB07_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB07"/>
    <dbReference type="STRING" id="1220162.K1VB07"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="InParanoid" id="K1VB07"/>
    <dbReference type="OMA" id="LDCEKPV"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="271" mass="29644" checksum="6432D759FC8644BA" modified="2012-11-28" version="1">MPFQTPPPETPSEAHIVVTFPAEHILHVALNRPRQWNALNKVTNEALDRLWDWYEAEPSMRCAIMGTTTERAFCAGGDLIEIGISPMPKSGTGLAGLARRKIKKPIIAALRGIVVGGAVEMLTNFDVVVAGESAVLSLPEAKRGVPAGGGGLPRLVYLVGRQKAAEWLMTGRDIPSREAERCGLVNCVVPDGEVESTAFDIARQTVANSPDSVLLHSWGLRLVEEEMGFDRHMDRFTQSAKYKAVTSGENWREGMNAFAEKRAPKWVDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB14</accession>
    <name>K1VB14_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB14"/>
    <dbReference type="HOGENOM" id="CLU_1050487_0_0_1"/>
    <dbReference type="InParanoid" id="K1VB14"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="2">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="265" mass="28622" checksum="A4CFC9F70D4EF803" modified="2012-11-28" version="1">MWSAATTRGLSLRMERIYHDVLKTGVCALHSPTEKEPKDMPGAIKLLDAPTPPQRKAEPVQRADAPLVLNGAIRATVNLHGHRHATLDATTVNGSVRLHVKRQASVGISVSSANGAVHLWLPQGFDGILSCGSGNGTVELSETLQRYAVIVPGEKGLVWHVRLPDDLDMGHHDHNPNLDLGGDLAALAMEGDNKLTDAVPKSPESEKSDADSRIVARRESDSSDGERKPGPDRAKAETANGKVRVYVDGEKEEAGCWWESRCEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBJ8</accession>
    <name>K1VBJ8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBJ8"/>
    <dbReference type="STRING" id="1220162.K1VBJ8"/>
    <dbReference type="eggNOG" id="ENOG502S9A1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1090664_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBJ8"/>
    <dbReference type="OMA" id="WGRVNIY"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="255" mass="25528" checksum="99734F4332A8F335" modified="2012-11-28" version="1">MFAVLLALAAPALATIYTTNPVAHTQAYGGQVLRVDWVDDGEAPNLPDIGPCSIDLCIGSETDQRCVQNLGESVDVSATSSISTTIDPSVGENGKYYFIRYRSLGLKEGEYPYQQYSARFHLNSMEGNFDDEVKQLATSSTDDFIWATGTGANASPSGSAAGTTNPGAAGASPSAGASGAGAVAAAPSGSATPSGSGKAVADTASSTSTSTRTSTTATRASASASPSPSADSGVAKFAAPGLFTLAACLAAYIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC73</accession>
    <name>K1VC73_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC73"/>
    <dbReference type="FunCoup" id="K1VC73">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VC73"/>
    <dbReference type="eggNOG" id="KOG4132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051874_0_1_1"/>
    <dbReference type="InParanoid" id="K1VC73"/>
    <dbReference type="OMA" id="DPYCQQL"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="273" mass="28946" checksum="2A3DC8988F382C7D" modified="2012-11-28" version="1">MDVLLFRTPSESDPYDAAFKTAGYRPRSVQALDDVLLPEGLAPILAAGGGRWEAALITSRRAAEAWCLAVEDAQRYPSNTFESWSSVPFYAPGGAVASVFDSHSLDSTWRPTEGGTAVNAAGLAPIILNAEPRLEGHGPYLVLTGDKTLPLLSDALTGAGRRLTRVQVYETACAASLPSSLGEVSEGWAAFFSPSSAACVLPVLEGKCQLPWDLSVVAKPRGTGPRIKIAAIGRTTEGYLREQGLRVEAVAETPDPEGLLKAIQAADARQRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCZ5</accession>
    <name>K1VCZ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCZ5"/>
    <dbReference type="STRING" id="1220162.K1VCZ5"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008524_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCZ5"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="600" mass="64080" checksum="0CAB5FD4D14D3784" modified="2012-11-28" version="1">MNSAAGPSSPNRNGGDPSLSPRQREKAPISPDSVNLPPNADHEITLLISEYLSSRHPRLADVLAAEVGPARDHAVTNEIEGVERAILALESLLSGPGLLGPQTLKAFLYMCYRQQFLEYIDNQGVQPAAEAVEAAGALPAGAVRLLQLGVLDLGVDSARCPGITGLGGRGPRTREARRYVARVNGWGTARSGRVWRGSRCIEQSAQGPAADSDQAGLCLGGHGCEPEYEGTGEHRDAFRRLHESRDSEPPEAHGSRTSGECEMRRLRGRHDGRQRIKSYIASGSGDGTVRIWTPHDGQCRSVLAGDGGDIYGVCWRPGREDNVVAACYDKILRSWDLETGKLIRTFSGHAQSTLAVAFDPTGKIIASGSKDKHIRLWDAVGGVCVQTMTAHLGEVTSVQFDHEGKYLLAGCKDNSNRLWDLRMQRNIYRYTGHQNTSKNIIRCRFASPSCSLIASGSEDGMVYLWEREGSAPEENMRSPASNSNSGASTPAQGSPMFFTTTTGVPNAMNTSLSRTSTISVPSTTVPRGPSVASPSRSAAHYPPRGIMQGPALPKSMAPTTVRPLKVLAGHGAGAVYDVRSHAGTLLSAGEDGAVGVWGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEN9</accession>
    <name>K1VEN9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEN9"/>
    <dbReference type="HOGENOM" id="CLU_816808_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEN9"/>
    <dbReference type="OrthoDB" id="2593944at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="340" mass="36753" checksum="EF0944320E752835" modified="2012-11-28" version="1">MPAATPAFRFQDLAVELQFAILDEVISLSPSDLCAAAVVCQTWNQYVTPHLYRHITLTKSNREAVFAGLGLDYLSAFALESRADDVPAVDTTPNRKVQALSHVKTLAISDSSGALALAEALVTHDGVLSNVEDISIGSALFRHLVNSGLAAFGRPRSGSAFMGETLVARLKPKRVHIDYPASRVLGSSAFDPVLLARVLAVLMIDWNPETVDYHGVGSDFPPVLGAMSRIHCAPCMPADGEWDDCDGLACGSHGALVRMHLRRLFGQHARDELLEAIAEGADPTDDEDLDPDDVPDALQAKVEYHGVPCIVGADMDAFLRKTFAHWPVEIDIGERVAFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFC1</accession>
    <name>K1VFC1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFC1"/>
    <dbReference type="STRING" id="1220162.K1VFC1"/>
    <dbReference type="eggNOG" id="ENOG502SFKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169812_2_0_1"/>
    <dbReference type="InParanoid" id="K1VFC1"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="84" mass="9212" checksum="FEC73252B5D2ACCB" modified="2012-11-28" version="1">MSMLLRAAPLRVAARRQAFQVRNAHFENVVDHTIPGNTRNKAGMAAKMITYTICGFGLPFVSANESAKRSAWCVQDHMAGFCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFM6</accession>
    <name>K1VFM6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haloacid dehalogenase, type II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFM6"/>
    <dbReference type="FunCoup" id="K1VFM6">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S0RM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_2_1"/>
    <dbReference type="InParanoid" id="K1VFM6"/>
    <dbReference type="OMA" id="WIERGEE"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34234" checksum="F3E612A6B6808900" modified="2012-11-28" version="1">MPLAKEDLARFNLTVTALLLCTFTPRETADRNQELYQRPANLLSMPLANLQTLIDWETGMKDALRPLSDQPGAPDPDTILATVGKHAQHIEGDQPRTLYPDVLEHAYEQAADELGLKWTQRDAELFGYSCPRWPEFPDSADALKKLHELGFKLTVLSNVDNRSFEGTRRVLERGFNFDAVYTAADIGSYKPSAQNFEYAMSKDFDQFGTEPREILIVANSKLHDLEPGRKLGFKGAWIDRKGAHLGVTGQEDFEPDWTFSSMADFADTVSSVLGGKPIHASKSDEANQVLTNDEEACKPHFPLSTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFN6</accession>
    <name>K1VFN6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFN6"/>
    <dbReference type="STRING" id="1220162.K1VFN6"/>
    <dbReference type="eggNOG" id="KOG2652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030027_2_1_1"/>
    <dbReference type="InParanoid" id="K1VFN6"/>
    <dbReference type="OMA" id="DFEEYAM"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="21020" checksum="EDD33E606F635C99" modified="2012-11-28" version="1">MANVAVDFEEYAMDEDLLAILQSARLLETRVADFALAPGADDGNAAGSSSRPPASQASSNGAAAAAAASAPEAATGETAVKTEPEDVLRLRGGAGEEGAPRPQPNEAGLLPGDEVIDSDLDDSDDELRDDEDGIGEEGEIDIVFCVYDKVQRVKNKWKTVFKDGMIHINGRDYLFAKCQGSSGNCVPTPSNTRALSYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG18</accession>
    <name>K1VG18_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 40S ribosomal protein RPS14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG18"/>
    <dbReference type="FunCoup" id="K1VG18">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG18"/>
    <dbReference type="eggNOG" id="KOG0407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="InParanoid" id="K1VG18"/>
    <dbReference type="OMA" id="IYASHND"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="150" mass="15652" checksum="CEC71FF005D033BB" modified="2012-11-28" version="1">MAPKAPKQQQAAAVSLGPNVADGENVFGVAHIFASFNDTFVHVTDLTGKETISRVTGGMKVKADRDESSPYAAMLAAQDCAAKCKEVGITALHVKLRATGGTGTKQPGPGGQAALRALARAGMRIGRIEDVTPVPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGA3</accession>
    <name>K1VGA3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGA3"/>
    <dbReference type="FunCoup" id="K1VGA3">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGA3"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_4_1"/>
    <dbReference type="InParanoid" id="K1VGA3"/>
    <dbReference type="OMA" id="FIQRPTR"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="71"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="677" mass="74961" checksum="0EA1E9EA49B40289" modified="2012-11-28" version="1">MADAKLFSELEARGQRDKAFQRKKTTALKKIVANMTMGNDSELSVQIRTNSSVAVVPGDNPGHADPGAGDQEENPLIRALAIRTMSSIPLPSIIQALVDPLRHALEDQDPYVRKTAAIAVAKLYASDYGKKTIERENFVAMLRDLLADHNPTVVANAVASLVEISDRSSDITLRLNATVAGKLVAALGECSEWGQIYILESLMSFIPQTAMDAEMLAERISVRLQHANSAVVLTTIKVVLYLMNYMEDEQLIRMLERKMGPPLVTLLSSGPEVQYVGLRNILLIIQRRPTVLQNEVKVFFCKYNDPVYVKLAKLEIMYRLTREENVSEVLTELKEYASEVDVDFVRKAVRSIGRLAIKIGTAADQCVMVLLELMKTKISYVVQEAIVVIKDIFRRYPSKYERVISILCENLDVLDEPEAKAAMIWIVGQYSDRIENSDELLEDFMFTFKEETNEVQLALLTATVKLFIRRPTAAQELLPKILKLATEEAENPDLRDRGFMYWRLLTTNPTAAREVVLSDKPVISTETDRMDRGMLDQLLLHTGTLGSIYHKNPETFIRTAKPRFLPDSPALNLASKRHLITSFGGPASRPRAPRSSDVAPQPTGAPAAASAGAEQPSVPARPAMNGTGTENGQAAPQQVSNDPYSQLAEIDLLGGGGYQTDVPQPRGNQGQQGDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHM2</accession>
    <name>K1VHM2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHM2"/>
    <dbReference type="FunCoup" id="K1VHM2">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHM2"/>
    <dbReference type="eggNOG" id="ENOG502QQD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="InParanoid" id="K1VHM2"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="589" mass="62814" checksum="9D9566091D5A3ADA" modified="2012-11-28" version="1">MGSPTEVTYNDNEKHLGQTADVDEKDATNVNVLPAGSSESSVVEGAELGHVPRSRKFNIKRFFRSLVTKEAWFGDYDYGSLFIPNIPFLCKASPLPFYGIDDNLPYLLLIILGLQHAFAMLGGVVVPPLLLSGAAGANMGDEVTQYLVSAGLIYSGFGTVFQISRRRIFKTRYWIGTGLISVTGTAFTFCNVSLKYLNQCYDNGACKKAPDGSKLPCPDEFGALLGTGALTGIYAIALAFVPPRILKKCFTPIVIGTMITFIGASLVTSGVNNWAGGAGLCSTNHDLLCESGSQPHKWGSAYYLGLGFSCMAAIVICEVFGSAFMKSSSVFIGFLVGMIIAAACGYFNTEVIKKAPGATFLFVHTFKLSIRGQLVLPMMAAWSVIVAESVGTITASGQCSDLDIASPEFMTRVQGGMLADAISGTLANLFTSPPLTTFPQNAAVIALTRNASRQSGYCCAFILFMMGVISKIGAIFVAAPPAVIGGFTTFLFGSVSVSGVRIMAFAEWSRRERFIATAAFALGLASLVNKTWFSYIFTYDGPNTGLKGFLQAITLVVQEPYLIAAVVAVFLNLVLPHEPVDPNALPEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHP8</accession>
    <name>K1VHP8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHP8"/>
    <dbReference type="HOGENOM" id="CLU_2016824_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHP8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="123" mass="14555" checksum="16903FA50AB87446" modified="2012-11-28" version="1">MLLASLVLLTLSTARTPVPYCNTTNDDTWRVLSCNYDWHKEWGVARHCPETKRGDHDSVWGYKCPLDKEEHERCNVAFFVEAGVRQLYCDREWSEEDQGDCPLIGHFMKDEIFVYSCSWRPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHX3</accession>
    <name>K1VHX3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHX3"/>
    <dbReference type="STRING" id="1220162.K1VHX3"/>
    <dbReference type="HOGENOM" id="CLU_070402_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHX3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="234" mass="23760" checksum="6518CFC3B38E14C5" modified="2012-11-28" version="1">MSSSFHCVAAEPSLSHCCAIFSGTLSNGYCHLSGVDSQSLSEQFTACATDSAVCREGAPPLEPRQRTTSTRPIRTSSAGPRRTPSARPGRTSSTRPGPTSSARPRQASSARPGRTSTSRARLTTSGAAASRSATPTSTRSAPSSETVTDPSAGQVIASGSSANLGSPASGSAIFSSSAARPVDQSVIVRTRTRPDGSAVTITSPIGQAVAHSPRVCRFSVLGLFVAAAVAILVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI69</accession>
    <name>K1VI69_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI69"/>
    <dbReference type="STRING" id="1220162.K1VI69"/>
    <dbReference type="eggNOG" id="ENOG502S76S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1442021_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI69"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20281" checksum="344B58A84F88EFCA" modified="2012-11-28" version="1">MGFFNHDDEDDRRAYQQVQEGNEAHFSHELLAGAASFYAMKKYQDHQEENGKPQSWEVAKDLIAGFAGMEATKLAEEHVRLDKGGADVSETKGADEVDKWRAKHEAEERAKHALSQSGEFGNPGYQRQEYNHEQHGPGARREFGNGYGGQNGYGGQNGYGGQGFGGPGGPGGPGGFGQQGGGYGGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIJ1</accession>
    <name>K1VIJ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIJ1"/>
    <dbReference type="STRING" id="1220162.K1VIJ1"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="K1VIJ1"/>
    <dbReference type="OMA" id="APMSELW"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="122"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="649" mass="70464" checksum="1E505906D1207831" modified="2012-11-28" version="1">MSQPVNPATSPIAAATLAERDIKEDCAPAVLLSPSTEKDAFPSSSATLGRGTASSLTESGHVDDEDHTLKKRSWHPRVTPWSDILQHEYKGAGTEADPYIVSWLPNDRENPMSYKPSYKWFITVMAATGTLAVSMGSSMLSAAVEDIKKDFPGHNTMLYIMITGIYVLGFVVGPLLWAPCSEVFGRRAMFIFTYVPFTAFNAGACGAKDMNTLLVMRFFAGTFGSSTMTNSGGIIADMFAAHQRGLAMGVFSATPFLGPAIGPIAGGFLSEASSWHWVAAVIALFAALLTAIESLLLPETYAPVLLRKRAARLTKYTGRVYRYEKDAAGTLDIKALFLNQLKVPYKLLFTEPIVFVISLYMAIIYAILYMQFTAFPLVFQGYRGWSSGTSALSFIGVSVGAFIALAYIIFWVNPQYARQHAKLGYLPPEARLPSATIGAILLPVGLFIFAWTCVPKSIHWMGPISGTVPFGAGIVLVFLGVSNYLVDSYLLLAASVMAAGTVVRSILGVVFPLFTVNIYDAMGPHWAGTFEALLAVIFVPVPILLYRYGRRVRRMTKAGRDADDLGIQITKMMQAQAAARTAAAPTELERQETRRKEEEMMSTSMVAGDVTSAGDYARDEEAIIESTAPSLRAESRASTHPAGEVKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ51</accession>
    <name>K1VJ51_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endosome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ51"/>
    <dbReference type="STRING" id="1220162.K1VJ51"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016552_2_1_1"/>
    <dbReference type="InParanoid" id="K1VJ51"/>
    <dbReference type="OMA" id="EPDYEEN"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="153"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="651" mass="69291" checksum="E18E45B66E499AC2" modified="2012-11-28" version="1">MSFSDEQVAASERVATSSASTDQIEPAPWMTHTMPPPTKMEGKSIHSRPALNSVPLKSYEEVAYARVDSPDLKTLTYDDDGPPTILIVFIPILVVLVTVLLGVLMFLIALLCMKRQRGIRLMEDGGPLDLSKGDGVIGEGGTEGVEQRWLENADPDVQEAYKRAKDAEKGVSAWAFEPDYEENLSLFVQSRTEITFLSDGPGMPVREGGGNSVMANLPLPKVNEVYYWEVKLFEKAPATEVAIGLATKPYPSFRLPGWNKFSVAYFSSDGFKSHNYPFTASSYGPPLAEGDVLGVGYRPRTGTVFFTRNGRKLEDCYTGLNRLNLFPTVGANGPCTLHVNLGQAGFVFIEANVKKWGLAPMVGTLAPPPAYGSERGSILLDAGYGTPGASNSHPNLSGISALLEAARARAAAQMNGGQVARPIPVGTSPPPGSSGSSRRHRRNPSQPVAPSPLRSGEGGPGPSTQRNQAGGTNYVSPTDTPLVAPRVPPADVDIVSDDGYDSATSAASSHRSPHNPPTPNVLDISLHSLRGENYFERSGRTSATTSDSSNRSLAPSAAESRASSGRSSSTARPNIDRVPSYGPPADSPPPPGYAPLDPHMYSQGLPGDLPEDLINQAIAAMSEPERPAAQPSPPRSGGPLNWIRDRVGRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ53</accession>
    <name>K1VJ53_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ53"/>
    <dbReference type="STRING" id="1220162.K1VJ53"/>
    <dbReference type="eggNOG" id="KOG2449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="InParanoid" id="K1VJ53"/>
    <dbReference type="OMA" id="GGAKNHI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="75"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="51201" checksum="EDF823D73C74B332" modified="2012-11-28" version="1">MLRSARIAPTTVRLARGYASSASNVKAAEISALSQIARQYADEVSSKWAGTSATGGNTKNFIGGQFTDSKAKDWLEVRDPGKTFADAQGDVGRGLQVVEAATAITSTLLGDKLEVTNDMDTYSRRLPLGVTAAITPFNFPAMIVLWSAALATVTGNTLIVKPSERDPGATMIIAELCKKAGLPDGVFNVVHGSANTVNAICDAPEIKAISFVGGDTAGKHIYDRAIVQGKRVQANLGAKNHAVIMPDANKNLTLNAVAGAAFGAAGQRCMALSVAIFVGESRKWIPELIERAKGLKVSGGFEEGADLGPVISPQARERIESLIGSVEKEGGKILLDGRGHVVPEYPNGNFVGPTVVEVDTNMSAYKNEIFGPVLNIISAETMDEAIDIINANKYGNGAAIFTNSGATARKFEIQAEPGQIGINVAIPVPLPMFNWSGSKGSFMGDIPFYGKTGLDFYTVRKTTTALWPHQDSLSSRAAVSMPQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJF0</accession>
    <name>K1VJF0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJF0"/>
    <dbReference type="STRING" id="1220162.K1VJF0"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_1_1"/>
    <dbReference type="InParanoid" id="K1VJF0"/>
    <dbReference type="OMA" id="FANENSM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="141" mass="13880" checksum="A072ACCCA22A4BC5" modified="2012-11-28" version="1">MKDRETGRSRGFGFVTYGNQAEAEAAINAMNEQELDGRRVRVNMANSKPAGGGYGGGYGSGCYQQGGYQQGGFGGQQGGFQGGFNGQGGYGGPGGYGGQQGGFGGCYGGAPPQQGGYQGGNFGAGAQQGGQGGFGGPGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJR0</accession>
    <name>K1VJR0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJR0"/>
    <dbReference type="STRING" id="1220162.K1VJR0"/>
    <dbReference type="eggNOG" id="ENOG502SCHT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279534_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJR0"/>
    <dbReference type="OrthoDB" id="2420608at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1127" mass="122596" checksum="5EE1A73AEBEE75E3" modified="2012-11-28" version="1">MSAVPSDPEGRPIAEPIGAPISDPISEPPAPAPAPTAPTRPLSRNVTPHLTSEEVSALRRASFAKLFERWNGISHKYGMIAPEEDDEIDLITGEITCDRGRIRALKTRAFARELPFVEGDDDDDDDEGDDEEDEGDDSDTPMPPQDDDATPEPEARNGTEEGHPLLQEQPWTAEDDRDLEEFMKVERMRRLATGEAPQDEPVPAELDMGLGANMGPGQMDVIAMLVRREVERMLGGGGHQPALPVPNAAAQATANGAPAATNSGPPQLNGSNGLPTVSERPAVANHRQVERTASIGLAAKHPVSTEEWLYSKTAPVVVKCFQKAKGKGRMAGERPNEDGNLRRQSAPPPRSSLSVEITRKERRASEGDVPERQNGSPSPLDPADPPKKRRKRRISDEEVDANGERAKFTPPNVYLKSLSYHEGKLRECRYCLDAGEPRSRYAALCRGRIDELMCRFPQMTEEEVKAAIAYREEEEANYAATQKPEARTKKRTKLAPPAEVVTEIPTSWRPRPGDERYSMAPHRVRGGSFKRCKLCVVAGGVREKRSMFCMGRSGYGKCAFEFEDPSGSSGDEEETPEQAAIKQMEHRLLRAQNARMGMVARVLKKEEVPAAPLRKSTTPYVSYRQQSTRPGLPATRGPSKAPEGEELNPRAPNGRLKPRCGPCLRAGGKRAERAFLCPGSGRPKYCEYAPSAPGQGAMAGPSEDDTEATDNKDSAVEAETFPDPEIEFIVQQPLQTPAKSSAKPESVTPASGKKPTVTSANKAKEHKVKEPKPKELNAKKKKRPRNSRLGMEESSAEDYETEESDHSLSFADSDDSADSSASEDGHIIRRYNRESTGYTLQSDESQDLSVPLDYGGADAADDEFEGVDTSMESAMESAEAVDPQILRTVAAGMDDFVPRPNTNKYAPYLSFSDGGEGWATCALCEAAGGSRAECAMWCYGRDGEHMCRLNPGWVPPEPPRSRRESQRMSSAERGDLPFSPEHSPDPLESDVEMDDIVPIGDLAVHEGGETEPEIGDSSFDSEPAPIVRRSPVPHSTPPPNSLRESGAHAPSHSPPRITVNGSQPPSTQYRDPAAFVASSDPAPSSSPRSAASYASPLPHAADGLQAALARSIKRDYLATSPRRTQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKH1</accession>
    <name>K1VKH1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rrn7/TAF1B C-terminal cyclin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKH1"/>
    <dbReference type="STRING" id="1220162.K1VKH1"/>
    <dbReference type="eggNOG" id="ENOG502S2NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495389_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKH1"/>
    <dbReference type="OMA" id="PRTNKRE"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="11">
        <location>
            <begin position="321"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="550" mass="61941" checksum="3433D4E5371665AF" modified="2012-11-28" version="1">MVISSIENHAVDYSAGHALQKRRVRKGPRTNKRELYGQRDQNYLADRGAADSAATASTGLEGTVGPSRCVRATSPLPSTSDQRGEGSRSPSPGPSRQQPSQPMADEKHDEKYDEKEDSDEDTDSERDLEAQFATEADEKSDEKGTDDENPLEDTAVDVSDDSDDDGADKEEGLQALEEVPTEDTPERPQERVITVSDTLICLVLGLWMVRAPFTVVNHNKIPFIEFFKSTQLPAEMKKRMNGPVARTSAELTADVTYEEVLSLLNMAEVNLSIVAPEYITIRPKPAEKRPDEVNNRQKKDKRAEEERRKKERAEYEITKQYSVIMPEMSIAAAWVIVMKLAYGLDGTERQALLPDDPLIGRPRAEDWLKELKKRKERGEFNYKQHLEHHEEAIDAFLNDAEEVLLKNREQERWAASNFPLPPKSRLPEAPTAWQSWAPFRAHAAANPVTQAPPIPSSTRNDALPLMPGEKIRSFDASDVTGTLPPDFELVADCAAQVAGVETQELLEIVEVFERRLEKLRPKRQLELGNSQRSSKKLARTHTILRNSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKH5</accession>
    <name>K1VKH5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKH5"/>
    <dbReference type="HOGENOM" id="CLU_2348176_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKH5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="97" mass="10258" checksum="4832C0FEA33B2B1D" modified="2012-11-28" version="1">MPVNLVNAGEDKGARRDPALFLALLSPRSPPVVRLMPVFIPLKVSPQRPAKSSALDQSTATTTRRVTPPQSGAGTSPTAPVNAEPNPQPDVQHKQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKK9</accession>
    <name>K1VKK9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 39 (Zinc transporter), member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKK9"/>
    <dbReference type="STRING" id="1220162.K1VKK9"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028824_2_0_1"/>
    <dbReference type="InParanoid" id="K1VKK9"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="28524" checksum="1E801A536324BC57" modified="2012-11-28" version="1">MTAASMAVGSIPLVFKDSMSPLSGISILGTGLLIGAALTIIIPEGVVTMMAADPHSMHTIGIFLLAGFALMLLVETFTPHPPHLHSHGESHPMLPKDPSEPSSPDPTSGLSATLGLVIHGAADGIALGASSLTGTAELGLIVFLAVLIHKGPAALGLTTTLLGLHLNHTQIKNRLLVFSLSAPLGAILTYALVSMFGANNGAAADGKYGLSWWTGAVLLFSGGSFLYVATVIQPLNKSDCHTERDEISRPISRAFLLVTGMLIPLGLALLVGDHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKT0</accession>
    <name>K1VKT0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKT0"/>
    <dbReference type="STRING" id="1220162.K1VKT0"/>
    <dbReference type="eggNOG" id="ENOG502RSBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2016827_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKT0"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13174" checksum="5214BFC84FA6D622" modified="2012-11-28" version="1">MGSNSNMIPATQEDKDAFQQGMLSNYSKGMIKDIEPYAYDPIPAVNAKGGRNVDGWRSVFVATVQKDWTNGLGNLHGAAAAWIVDVISSVAIAPLATDTWWGPPMLTGVSLAIDMLYFNAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL91</accession>
    <name>K1VL91_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="4">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL91"/>
    <dbReference type="STRING" id="1220162.K1VL91"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_1"/>
    <dbReference type="InParanoid" id="K1VL91"/>
    <dbReference type="OMA" id="CVILRYF"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="397" mass="42457" checksum="B1BC3247FABF6FF9" modified="2012-11-28" version="1">MAFYSPSASSVASFSDASTAPTTPGSGSPPPGPAYVLVLGGLGFIGSHTALELLKAGKNVVIVDDLSNAFETVLSSIREAAALWCNVNGRTVPALKFYEMDYRSPGLRLVLDSYRISGVIHFAAFKSVSESIAQPLDYYMNNVCGLVSLLKTLDSYGIKKFVFSSSATVYGTKAEQGIPLREEDVVHHPHTYERDGETVTAIPGAMGLTSPYGRSKYFGEAILADLAYSDPSWSVLALRYFNPIGCDASGLLGEDPRGVPTNLFPVLAQVLTGDRPRLEIFGSDWETRDGTAVRDFIHVSDLARGHIAALDAKVDEPFRTFNLGTGTGTTVAEAHDALEAASGRKIPAVLAPRREGDVGSCVAANARATAELGWTTTESLLQSARDLWRFVARVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLF8</accession>
    <name>K1VLF8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000160">
        <property type="protein sequence ID" value="EKD05015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLF8"/>
    <dbReference type="HOGENOM" id="CLU_874892_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLF8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="318" mass="36021" checksum="1238496819EF8D78" modified="2012-11-28" version="1">MSKPKSSKKGATTVLPAFLDDESATVRYALHLMMSIDEIIRAGRLLKALWKEQQIDYNLSHISRVQVRPPHRLILFARDHEFHRLLQDNGFPVSNFWRLSVKEGRSTFVSPTIILATIQLGNLYELELWSAQQASVRPVVVFHFSKGSDDWLQHRAPMTHTLKKAVLRKAFSEVKVILPKLKSSDKCEELVRAMNKTRTEIGSGTSGEAQIWQVHFSTPAVHARDGLVSLYEQTVSGEEVNPKNWLATDTNWKNGRMNKRKEPDVTKLRASATAQVKFWPVLMRDSRGGKKKKAEANTKARKGRANKKTTTKKAANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLQ7</accession>
    <name>K1VLQ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLQ7"/>
    <dbReference type="HOGENOM" id="CLU_2198838_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLQ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853907" evidence="2">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="108" mass="11940" checksum="A068AFC6162AF877" modified="2012-11-28" version="1">MMLRTPLLLAALALTTALPIPHRDARDHAHHKRELPTPGAAAPNLAKRHVEVPVPQGGSFHNETHWWVPDTVHHGLVEPDRQAGDNTDIGGRRVQMHIVQGRAKTSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM68</accession>
    <name>K1VM68_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM68"/>
    <dbReference type="STRING" id="1220162.K1VM68"/>
    <dbReference type="HOGENOM" id="CLU_564038_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM68"/>
    <dbReference type="OrthoDB" id="10635951at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="484" mass="51744" checksum="AE2D4024DC5B9089" modified="2012-11-28" version="1">MGLFRQQSWSRSRISLRRHRDSSAPPSPTPPLPPALFSSVNDSPRTISRQLSIDSTAALSTATTNTANDTLATAQSSTPEASTPDAEPTDAEIMTAIPGSYINSQSLGLSTPTPTPLTPPAASPRPLMSPSPQIRSRSLSTGHPSPIVGNPRPLCAPVSPRLSPRPSPHLSPRSPQPRPLMPPGEDDITPPDTADTCTFSPSDVGSAVNPTSHGHVEVIPYLVSHNVDLHPEFTTGDMLLLAGDRGFRCHSGLLRAWSGVFVQQLKTERFARERVIQSLDSPEDVHAVLSFLYGRDRAHLAPGPSSSGLGLYGTLPSIQVEDAGFSLAQFRAVLAFAESYDVQPALRDLLRHAVDAEAKRLCANRPNGTDVLGLVMLAHAARSAGLWKELIRRAWPKPDGIGYRPPGPEWRAISSPHYIDEPTAQRLGSAQPLLILIARVHSATGEVKVTYEKSELPVTAEELTADAAIVTGGKDGDFVTSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMH2</accession>
    <name>K1VMH2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome condensation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMH2"/>
    <dbReference type="STRING" id="1220162.K1VMH2"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1644916_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMH2"/>
    <dbReference type="OMA" id="ASIRIFC"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="161" mass="17417" checksum="EA71317C7EA5E9D9" modified="2012-11-28" version="1">MATDIWNDYPHFVNNFIPKLTVPKLKHVAEAITRIAGINLHLRSGERKQDVVDKIRTAFETIKRQNNTGVYRAVRKGAEAIANGGASNPVMPPPTFGGVHLNHHYGGGAARVARPQAPAARAGASSGWHQAPGASSLYQQHPTHQNRLEAEPDVEADKGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN16</accession>
    <name>K1VN16_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN16"/>
    <dbReference type="eggNOG" id="ENOG502QRHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061316_1_0_1"/>
    <dbReference type="InParanoid" id="K1VN16"/>
    <dbReference type="OMA" id="HFNLPWH"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="108"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="315" mass="34785" checksum="D4FC7497ED607ABA" modified="2012-11-28" version="1">MLRGLRGTLASANLGLRNFSTTASNMVLRVGWHREHFLSPLLQLAEQDGGKTFTLVECPGGTGDMQAKLKNDEIDVCIALTDALTAGIANGQKSYKLVGRYISSPLRWAIITGKDSKYQTVDDLKGTTFGISRLGSGSQVMASVLSLNEGWSQADQPQFKVEGQFKPLRDSVNRGDTSVFLWEWFTTKPYVDSGEVRFIGSVYTPWPCWSIAASPNADNKEVSSFLEALQPYVRKFDSEESRAGPAVEFVAKTFGQQPEDVKEWLKSVKWEHNLDEVSEGVLKTTLETLEKAGVVKDAKYDIKDFVNTDVAKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN79</accession>
    <name>K1VN79_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN79"/>
    <dbReference type="FunCoup" id="K1VN79">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN79"/>
    <dbReference type="eggNOG" id="KOG2424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062463_1_0_1"/>
    <dbReference type="InParanoid" id="K1VN79"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="363" mass="39807" checksum="FEE969264A189190" modified="2012-11-28" version="1">MDPRRRGGDPRQRGNYQQNQGYGGPGGPGGQDGGYGGRGGPSQGGYQQGADPRYRGDPRGDPRDARRQDPRRREDPRGDPRGDPRGDPRGDPRGDPRGDPRGDPRGDPRGDPRDPRDPRARGRGPPGPPGPPGMDGPPRQDPRDMRPPPDAVARNGAGPPVPQPAEEEVGPSIRQRPLFCVVCASNNHVARTNNSNAGLRVISAGTGSAVRLPGPAIDKPNVYRFGTPYDTIYKDLESKDPKLYTANGLLPMLDRNRKVKLAPEKWQEQRNILADVVITCEERCYDAVCDDMLARGGEFNRPIHVINVEIKDNPEEAHIAGKSILELCQTIEKARDIDAEMDDILVQHQERHPHALLHTVAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNA5</accession>
    <name>K1VNA5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000042">
        <property type="protein sequence ID" value="EKD05665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNA5"/>
    <dbReference type="HOGENOM" id="CLU_2005506_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNA5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="124" mass="13454" checksum="8EF2041EDCA0C824" modified="2012-11-28" version="1">MAARVMMSAVREEAAMVSTEALAAARSTVTTEAGAVTRQAAEAAFNPLAAKEAAEANARNVVHTTGRLRFVFHVLTSFRKVVTGSDGTRIARSGARRDPEDDFVDVHRWKHDSRGSRCRGKRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNS2</accession>
    <name>K1VNS2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNS2"/>
    <dbReference type="HOGENOM" id="CLU_434245_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNS2"/>
    <dbReference type="OrthoDB" id="10640869at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="630" mass="70929" checksum="B797F664299F74AA" modified="2012-11-28" version="1">MLRRFVVAGPSRALLARQLSTATQGAESTAQPASTVSSTPSPDHTGVPQATLQRLIDIASRPAGTQSRQDRFEAWRIYSNLAPVDRSRLSSNELRAILRVMAPRYDEAWGMATRESDIPKQRIKQHTARMRQGHKIENSLQAVMEELMVRNENNLNDWLFVLNALGRLGRVSTIEAILSKAPEEIRDNRRVLEARLGAITNWSRSLSSAFRKPRLESIQIAHDTFWDVFQRISSHNQDLNGFTLRLLLTSISSVSKLVATSGQQEEGLERLDGLFRYILAQAYGLDLDNLAVSVQARDAGDATRTGLAKLSAKGLTAVMTQLAAVKTDPYRMIATYELLTKMPRAAYTQEEIYEQEEEDDDYYVTPDVPAEEPITEAEASLASEASSSYQGFRTMDQFFPPSTKPAAVSALPAKEAARLSVCKPIFSHETITVLLTDFLERGVDRALFRHVLRSAIADAQDARARWLAVYLGCPDSRRPRLRKSVRLSPEWFKQALERDDLELGKGSGQTALLIQRVLDWNTEELGVIFNKEKEIRGCDDLESLLEYPPWAKDPRIRRIKRNLEVCIIPEEPKTIASDTRTLKGLLERAQAMASQRSESRARQARNRSIREAEAEAERLREEAEQQEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNZ0</accession>
    <name>K1VNZ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome organization and biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNZ0"/>
    <dbReference type="FunCoup" id="K1VNZ0">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNZ0"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="InParanoid" id="K1VNZ0"/>
    <dbReference type="OMA" id="WLEKNTI"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="344" mass="36744" checksum="085BB04FF4530ED9" modified="2012-11-28" version="1">MPLGAADPTPLYTLPLPTSLGATSCTWVSPSDVTSDILVAAGGVDRATHVYQLPSLEPDIAASEGATAREIYTLMGHTGPISSVITSRTGKDIVSASWDSTVNLYVVPESEPDSHQVDAEPTSYLPGQKKRRKLHGDAPRNIEGLTDGDAGAAGEGWRRLPDLQFRGHRGRVGAVVWDVNEDLRVWSAGWDGSVRQWDAETGANVLTRQGPADKALLCLDQFQGSGQLATGSMDRTVSLWDTRQAASVIAQSLNVGSPVPSLQCHPRSSFTLATATYAGNVQIWDVRSPKHALFSVRRQGELNRTETKNGKVLGERLLAVAWDGEVLAAGGEDGEVGVWKARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPC2</accession>
    <name>K1VPC2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPC2"/>
    <dbReference type="HOGENOM" id="CLU_1670625_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPC2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="158" mass="16613" checksum="B728F0F80D3DA3D3" modified="2012-11-28" version="1">MPADIATPRPPLFSSSYLDLTPLGATRRLAPTSTSMRRAALEFDSDSDTSSLSSAQSTPLPPTPSALPLSPDSREPSPSPTPPAFIMSRGRAVPIGGVAMQRTSGSLGSDGNPFALKQEAKRQRERGLSDPPSPSTANVRALRPAASVMTIRTVEWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPY6</accession>
    <name>K1VPY6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPY6"/>
    <dbReference type="FunCoup" id="K1VPY6">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPY6"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_2_0_1"/>
    <dbReference type="InParanoid" id="K1VPY6"/>
    <dbReference type="OMA" id="RWPVCVT"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="300" mass="31377" checksum="E7FB0EE36FA07E91" modified="2012-11-28" version="1">MTTASTTPSLSPAELSYIVDGLKGTPPTRSDGRGLLEPRDIGIEYEVAPAANGSARVRIGNTEVVAGVKLEVGEPGPAKVAVDVTPQALPSLQSSALQALSTEYAAHLSEHFIPFVPRLPITKERAFLPSLHLTVVSAEGNIITALTLAARAAFSDLEVPDTKVIAWTGDDDASSAADKSGFGALKDGARGKGKGKARAKGLDDWDLGEGTHRIEGREELPVLLSLNLVQGSENTFLDPTPNEEAACPERILAWFRPNGNVCGIRTEGGLGIEAGRMRGLLEQAQGLATAMAATLNADLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQI7</accession>
    <name>K1VQI7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQI7"/>
    <dbReference type="STRING" id="1220162.K1VQI7"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_4_0_1"/>
    <dbReference type="InParanoid" id="K1VQI7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="432" mass="46293" checksum="C7A31BCB24BD7F50" modified="2012-11-28" version="1">MSKPQLIARVRSKADVDAAVKAGFKAVDYNVDAAIPQDAVSGLEAYVNVAPSVLDTEAPEVKHGTTVYQARLYSALNYVNILWDLQKTAPLAVRDMDAAHLRLFIGSGYRISTLRVRMSLLDRRCELNGLLQWCRENGVKVLAYDTEFGGFLDAAEGLKDTEEEGDGQNASHAEYVRSAGGWDVFHTAIKALDSVAHRHGVPLSALSAAYVASLGVDGIVLPPSAPKLPTLTTSDVDAIRAAVNDLKTPRGDPGDETKYPAYLSALPGDPKFNAHRAERIAEIERVAGLGGRIEASSGARWEPVAEYSRGLRVGRFFEVAGTTARAHPSGKGCLGKDAEDQATQIFDIVAGAVHAVGGDMRDVTRTRVLLKDVEDWPGQCKVHGRVFGRFGVRPVDTMVGGTVPIIEGSRVEIEALGVIGGHEGPLMRVGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQP5</accession>
    <name>K1VQP5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQP5"/>
    <dbReference type="HOGENOM" id="CLU_2851322_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQP5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="65" mass="7185" checksum="8163AE326D7C2341" modified="2012-11-28" version="1">MPPLQKAYRYFTNPDLLGGDIDLRLVPLEPAHFAQTDTSLNKLLWAVFPVNAWGAEELADTSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR72</accession>
    <name>K1VR72_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR72"/>
    <dbReference type="STRING" id="1220162.K1VR72"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373061_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR72"/>
    <dbReference type="OMA" id="PEFPRIR"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="364"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="667"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="782" mass="85053" checksum="98F1839E0F756E25" modified="2012-11-28" version="1">MAITQDGGGAGASGSLSVDEETDLALLDQHLIKTNALSQRMKTILSQLDSRLSRLDKSVAPLGIRQLSYTSKNLDAVLETLAPGSTAAARPQPSRQESYNSAALASVHSSIIDVPPPPVAVSTQSRADKRRKHGSIMDRGRAVSRPDNVPRWQEEEASMSRSVEVPPPSQWDSGISSGTDRGVLARVPDLSSLNEYMAALQGVIQELEDMNRALLEGRGGDRAAGVESLGNLVEEAYGKLVELLLRKTKEGLPRPFNPASLAGSTVPQPLTWFPEFPRIRHLSAPLSTMVYPDEPTPKTTGLLAPIFDDCIADLGGIRGEWFRQSLAPAAARVDEDGGSWDANQGGEKVRAVMNLWEGFLTAGEVALQSQLMPGASGEMLVGKVLSYATPVLTGVMNNVTASIKRDLTGQTMLLLDLYANLTEFQAKLDTRLGQIFGTREAEEVAAVLPNAMAVLKQLAQRSFPERLVDIRNPSRNNVANVGVDPVTHSTLSYLEVLPKFGSVVDGLLRSGRGERSWLMGLPPPSPAKSAEEEGGVLNLYVADILGALIQHLEQKAGPMRKMASYTYLLNNRAAQVWQRRGRSPAEWTRRAVMAHGPAPAVTSQERRGGRRRAQPLCGRHSRRADPAPRAEGRTHAQDGILHLSPEQPNTTSSFHADCVGVSAENMMNKAFRDAKAEWSDLTKLLQHTAHARFGVGGASEKQSTKEAAAAFFERLAELETQCRSYPLNRADPDLRDRVGAEADEIVRTGYKAFWTKGHNKGFDKYLKGTPEDISRRVQAVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRZ8</accession>
    <name>K1VRZ8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRZ8"/>
    <dbReference type="STRING" id="1220162.K1VRZ8"/>
    <dbReference type="eggNOG" id="ENOG502QVC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_593373_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRZ8"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="461" mass="47984" checksum="5B085E512FD47784" modified="2012-11-28" version="1">MQPHSHNPVGPDQTRHSQQSQHHHPYQARPASSSSAVGSTSSASRPRTANSVSPNNTSSDRPPKPPRKLNRSANQLHRNQACLPCRRRRIKCDAAKPHCSSCIRSFRFLARTQPDPEREARGVQCVYEESTDNEPVGGGGVEGASQPSLHVDPDHPRNTVLKLEGRIAELQDALARLSDGQQALGVSISAPNSATFPVHSSPHQHPLSAGAAGAGGHSVPRSMSWSTVDSNVAGGGGGGTGVGGGSAFSPQQYSPAPGPINPRFSFDGAAGAGMSPALGPSMISSTPLSSSPIQEHSTASHRFMQPSHTGVSHHHSLSGHSGVMDMGIGGMGHMHHSLQGSRGTANVLSDCGYQTAGMHNPALPAYQQDLGTDEDGGRGASSAGGGQYMDVFRQGWTPYLAEPSLIDHFVQTFIAAPSAQLQTPTPETPLSLGFPPTLLRSGSPKAQVAPTLAPTPTALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS59</accession>
    <name>K1VS59_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein mgr2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS59"/>
    <dbReference type="STRING" id="1220162.K1VS59"/>
    <dbReference type="eggNOG" id="KOG4096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1653383_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS59"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16832" checksum="F17EA5C6D32BF2D1" modified="2012-11-28" version="1">MPPPPSTTAGGSNFDKMKMGALMGTGVGLTIGFIFGSFSILRGGPGPRGALATLSQYMLSSAATFGFFMSIGSRALLLLWPLRSLWAMGDPPAGELARPSSPGSPFYQLSWPSPSADLQVIRTDARHALPAGTSPYAQVATEPYRAAFRRAQAEKLARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSC0</accession>
    <name>K1VSC0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSC0"/>
    <dbReference type="STRING" id="1220162.K1VSC0"/>
    <dbReference type="HOGENOM" id="CLU_050729_1_1_1"/>
    <dbReference type="InParanoid" id="K1VSC0"/>
    <dbReference type="OMA" id="RVGNAND"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852375" evidence="1">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="30281" checksum="0F5E8A4EF26B4DDD" modified="2012-11-28" version="1">MIALLVALLYATCALAGELHRPVIKYPDSRRLGLDLVAALPSRTKKVTVWSGARANKIPKGCADVVRAHKLNTKDITVVDVEYNDSDIVYALCHHPKAKMSLDKLIDWYGKAPGFLRTNARHVMAIPGTGASGIASNDNVAYFSDIGMQGFIHELGHELDTWCAFPGKKKAWDKCRDTPIWREAFNEDWAAVTEYANANHGENFAELTVHALYQWHVQGGIDRLGGTINGQPAKSSYEHEVGRIMDFCWKELGGTTHVRKEDGYKEYPVVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT45</accession>
    <name>K1VT45_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT45"/>
    <dbReference type="STRING" id="1220162.K1VT45"/>
    <dbReference type="HOGENOM" id="CLU_1138690_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT45"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="244" mass="26975" checksum="C128565BFF65D959" modified="2012-11-28" version="1">MSGTQITHWPSIDNLAGWAKVEVLRLSCAEAKELTPEAVLKHDPTKLSGDPRVDRPFLIAKLEHLTMLNGVPVSSTERWDAELYYVHFINALPSANPDHWGRYDELVAKHGKGPKAVSKGPQTLKSKLLSESPASWSGFIPVDPVSNKCGQGLSRAQLTTDLNVIPPSGHSFTLRALPSMSIAMLRKKIAVKLKQSADTIALWTAFAHKDLDGFWERGEQMDTSRDVGWYLNEHDGTVLVSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTG1</accession>
    <name>K1VTG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTG1"/>
    <dbReference type="STRING" id="1220162.K1VTG1"/>
    <dbReference type="eggNOG" id="ENOG502S8VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019366_2_0_1"/>
    <dbReference type="InParanoid" id="K1VTG1"/>
    <dbReference type="OMA" id="YACSKVY"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="683" mass="75254" checksum="4D522215CECD1D14" modified="2012-11-28" version="1">MQATSEQAISLQATGPSSPSSAAAHTSAPGSSPLLNLPTEVLHQVLVESGNTDPKSIAALARTCRDLCELIDESTALWRDLFLSTYDDPRRAAAYPTPRAADWRQEFQDRAWVQSALRRGEERYGELQESDVDRIANTLLGLYLDLPADADPDSGNPFAFFAARTRNVPLLTPLLYGKALRHLYLHTQTNRLEGGHNLRRKNGLHPGLSRLHCLMTTELDDDHGRIGVYRKVLRNHRGLMRETCYSARNFKSRNDWGPFTPQGKVEWGLLNALSTVMRCARADKKLAVAGGCHCPLSSEVVAYPLPVLVVARATAVEGRARAIALGEVGDGPGDVPHPGWMSNLSKRFRRAQASARMSGRDASRQALGSGRSPWVIIDRPPVAGQSVHQFRVAIFQTSSSFRASRPGSRTDPSLDKRTGPLPQWMLNAVDVLDLEDEGSAWLRTPPPIGTGVSAVRSQGFLDHTRPNDLPDDQVWDWAGVAGPWAGTYAYLEHRIFGQAAVNTWDGRQEELLTPLSYADWLRLNHPGMLAMESSLPRLDLTTYGEAVGDLINLYAIVDARPEDADVACSAIEGESVVLPRIETSLETSAQYPPLYFHSEQRLTGHMAQRGFIRGVARVTPDNPPEVRWTIIIRYGGEDRWRMEGVQVGGRGSKRGFFGVSNVHAAAGVGERLACFHARRRCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTV2</accession>
    <name>K1VTV2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000348">
        <property type="protein sequence ID" value="EKD00113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTV2"/>
    <dbReference type="FunCoup" id="K1VTV2">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTV2"/>
    <dbReference type="eggNOG" id="KOG2773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018299_2_1_1"/>
    <dbReference type="InParanoid" id="K1VTV2"/>
    <dbReference type="OMA" id="INFMAPN"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="157"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="333"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="434" mass="47857" checksum="A84E619EA94E5067" modified="2012-11-28" version="1">MVSLAEQLKQLEDDVPKTVDPEEAYADIDGHDLSRSHAAREHYTDVGPSALRRGEVAQTLLSDKYEGKPTSRMKIFDDDEEASEPEDEPGYDEEEEEDEDEEHFDEDEEDYDEDEGEEEEDDEDEEEEDEDEGEDQPAPSGKALDPMGALKASKMKDIEKGGAIKRQRDLFDSLMTTRITFQKALTTAFGLPVPLPSDPAGEIPSTRDSVLASLGKLNDTLLSLRTSLILPGSEPVPKRRKTDSDPTSEEYWRDSATDSFALVDASHPALVPLLAKWSTKIQAATSALGSRAAGGSKLMQGTKPTGVVDAIDASLSQKRDKSKPLLEDAEHAYRALLREVIESKQGTTPVDLMHLRREKKRKREAERGGSKGRRIRYTVHDKAVNFVVPVPLNGWGEEQTDELFASLLGGAGTKGATSEMPAQENVELGGLRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVL9</accession>
    <name>K1VVL9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVL9"/>
    <dbReference type="STRING" id="1220162.K1VVL9"/>
    <dbReference type="eggNOG" id="ENOG502SGQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1046578_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVL9"/>
    <dbReference type="OMA" id="VEVWVIR"/>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="29492" checksum="42B131B45382CFF1" modified="2012-11-28" version="1">MATTSKKTKVRAPSPAPSTSSDSSSASQSSVDSNDIDVAPVAPVTKKQRKSKPGERLYYEPPPGMEQVRINVNYNSIFEWDNLNSKEGLEVWAIRLPVDLKPSHLSGLSTNVKRDRVSGSLTHKSATYELTESEDISDLNSLNLLVPKKTSGHLFRAPLPIKRHLIIQPPKEDNLVSSSKKKLESENRSTGPIPNKTRQMPSNMKFRNPVNGFDTPGPAARPQIADEVKETVTSKEDKAAKKEEKEEKKKKRKSEAGESPVKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVQ6</accession>
    <name>K1VVQ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2C 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVQ6"/>
    <dbReference type="FunCoup" id="K1VVQ6">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVQ6"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004544_4_3_1"/>
    <dbReference type="InParanoid" id="K1VVQ6"/>
    <dbReference type="OMA" id="ANATIIM"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="344"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="611"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="949" mass="104352" checksum="B26FFEB679BEDE23" modified="2012-11-28" version="1">MLTPADLSSSQNRMPPKGSKGSPAKQPPPAKVPAADVGQLESIMQNMSIRQDFVLADAHPRPGYGTQGQPVKVTANMFPVRFNKPNLSIYHYDVEITPVVKVQNQKMPKNLASMVWRQACIDGMSRPDSVAFKNAVFDNQKNVYTIDKFELGENGKLQMVVAVPEPDKTEVDDRRRFKLSVQPAEDRVGNPKVVSISDITKFCLAKGEVLSNMEGVLTAMQAINILLRDDPMTKYTPIGARGRFFGLQDQTPISGGGVVGKGFTQSFRPTSKDGYGAIQLDTAFTAFYQSGSLVNLATEILGLGGGGGGGGGGRGGRGGPRGGRGGRGGGRGGPPQQGGGGPASLQEITAQQGRRLSKLLYGKKFTLPYRQFSIKRISSAAAADIKFLMNGRDGAPDRNIGVIQYFKEQYNITITKPRLPCVVYGKNFMVPMELVHMSDFNTINFSDLTSDQAADMIRVAAQKPTARLEAIKRWYSVLDYNNVPKIKAWGVEVNNLPMNVMSRVLPSPKVTYGQGKTVPTNFGAWNLKSVKFAEPGNTLKSWAILSLDRYCGPPEMENFRRQLVQTMKTYGIALTNENPPCVTARHQSLKDNFSEACKEAYMKGGKQDPQLIIVIMPRRDVELYKNIKTVASMSLKSWVPTQCLQWTKIRSPKGQDQYFGNVSLKIQSKLGGVTHDVKLALEKDTMIVGADVTHPPPTRGLIQPSIAASVAGMNSNNNKFESSIRLQEGRLEIIGRLQEMMEEHLRTFQKHNRDPPKRIIFFRDGVDEGQYKKVCEQEFAAVKAAAKACGGPKYNPTVTFVVCAKRSDGDRSGNLKAGTVVDVDVTHPFAFDFYLQAHAGLQGTARPTHYVVLRDENNFNADAMQRLCNDLSYTYLRATRAVSIVPVVYYANIVCAQSRNMTYNDDDVSDTTTSYSGSGVKQPKDAAFDPNLIAKRLNKSPVKEVAWFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWE1</accession>
    <name>K1VWE1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase/acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWE1"/>
    <dbReference type="STRING" id="1220162.K1VWE1"/>
    <dbReference type="eggNOG" id="ENOG502RVEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_2_1_1"/>
    <dbReference type="InParanoid" id="K1VWE1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="242" mass="26008" checksum="CBF5FDD926223BCA" modified="2012-11-28" version="1">MPHDLSDYPTVILVHGLFSNGGHWWKTILALKDKGYGIDQINAVDIPLTSIEDDVAVVKRAIEATPGDVILVGHSYAGVVISYAGTDIKKVRGLVYIAAIVPDAGESVSDILAWDPAKCADAIKPTSQGLLYIPPNEYKHAMCQDATADEAFTFATSQKPPKQGLVTEKSGNKPAWKNQPCYYAVSKDDHLVSPATQYKLVQRMPTNKTIELLASHASMNSHPQEIADLILSAAKAAAASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWN4</accession>
    <name>K1VWN4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWN4"/>
    <dbReference type="HOGENOM" id="CLU_1027399_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWN4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="296" mass="32694" checksum="DA34E991D5369574" modified="2012-11-28" version="1">MGMWFNYTFGLSEAINSLCCPPDNATNAGAWSYCAVAVGPYNGTDEKDMTSYKVGGCFAEHNVTDIRVYLQDKPEGPPSAAPRLVSKPFGVLSFVLLTLAFTSGTLAQTEQTRPNQNDELSQEVFAQDDKDNDLLRKYGTLANTPMCTHFEPDPPDKWRMDSTMPPISYGQGTPVFAAGIDDGTHTGRWLNVTWAADVPVTGDWDALQETLKKNLPQDRFDRLRERVYVPSVPDMFFFPQHPARTGRVAVSSTAVMVPGTFSQCNTTEPTHRGNVRIPYEDGVFFFAASLPPTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXF7</accession>
    <name>K1VXF7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_01632</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXF7"/>
    <dbReference type="FunCoup" id="K1VXF7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXF7"/>
    <dbReference type="eggNOG" id="ENOG502SBRX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177920_1_1_1"/>
    <dbReference type="InParanoid" id="K1VXF7"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD04157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="84" mass="9649" checksum="083AD9B22010A4CA" modified="2012-11-28" version="1">MENPHEAEQTRLLERIIKNVDKCNEAVLEMNNCVKVSFVQACELIVQEILESSHAMVMSAQLFDNYTDSAANYMENLKMMPKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXK6</accession>
    <name>K1VXK6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXK6"/>
    <dbReference type="FunCoup" id="K1VXK6">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXK6"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXK6"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="8">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="212" mass="23413" checksum="9D7750A2337B820D" modified="2012-11-28" version="1">MHGDLALQLVTAAHRSTLASAPQLPIPKYALQLILSICLETRQLGVTIAAATEQHGVSLSQDRGLVCALTVQHLAARRNKRCMLAYLANRIGGIKERWWDAGGALSFVLSQETGDPDAPDLRSALSPQELDFLRSYNSMVLDYKSDFLDVLDIAASIDKPPGELMADVRVIKDAGEVILEGGERVEFRKGERFRLERAQVERLITQGYLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXM6</accession>
    <name>K1VXM6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXM6"/>
    <dbReference type="HOGENOM" id="CLU_761155_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXM6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="364" mass="42151" checksum="E1EDBE900B1A35F3" modified="2012-11-28" version="1">MGQPTVAELDRQAFQALRTLHLKVFPPNQRTQGIFNEQDMRLKSLMKDMDCSDLAVREAWESFISTIVQSRGQSRREGTPAARHSRRFRPYHTSADYLRPYSSDLLRILDSHDHPTRRYPYHRHAESSQEEGVRDLEILPLESPDSPWRTGWNWVHTSHTRSATPEDEPPRELTRASPRARSSSPDTSASAWLQEWESANAARTRPADVPPLRRRQRFHQNRPRSDATRSRTFDELHARYRTTEDERAAALRIARRDRDRDTRRDGVVFPDTWQETIDAWDEEDDFWVAGASMARSRPQRPERSERSAEAASGREASLGARETGEGVGRSERLIPHVEVPGHERPPRRIAPLPRRARANERDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXP5</accession>
    <name>K1VXP5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXP5"/>
    <dbReference type="HOGENOM" id="CLU_584209_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXP5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="540" mass="60952" checksum="C3E48F9AE1BC84EE" modified="2012-11-28" version="1">MERNLTEALLRQLTSALVDVAGKKEPYQEQKWDPHHHCLRNAGICCHPPPRTWSGKPHLDQALLGTTVKNVPRHSNRFENLERITEQTLAQARRPLKDFYTLVKQWLPKPLRSSTEANLSVNGGNDSVNLGHIKSTVPHEFRYWRLLFGEPELLIPIFEDDLEVINFMAWSRTPEAQPLVDQITAPGAGISTGRKIEAVQYKFAAITSDRVIDTGNTYGIRINFAQYWYALESTATKWSTVNLGSGAQCLAAHSAWGTMRIWAENGLLLLSFLPVYRAPDPALWGRGLGRVGVIRMIWIEELQSPRAQRVAFHLMQSQLAVLESAVVQVVAAIRAHTPKCSFNDDYIRRRSTPELFNKDDKAAWRVKQLELRCQAWILGLESGTLLVDDAGDSRSRGSPDHRIVMEAFSIWKDVLSSPGSKQLHACLAMLSEPGSTAPAAEAATSADINHYLPSPAHRCDICDVLEPIFCGKLREHSDLTRLILCDAQIPARQQKEWKEHVLLSCFEMLHRIGRCCEFGRIIPEIAESIRPWDWQTAWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXR8</accession>
    <name>K1VXR8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000117">
        <property type="protein sequence ID" value="EKD05346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXR8"/>
    <dbReference type="STRING" id="1220162.K1VXR8"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1750995_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXR8"/>
    <dbReference type="OMA" id="AMEFIAC"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15681" checksum="9F1B3B5C98867BF2" modified="2012-11-28" version="1">MWVVPRFRAPHILAVGGILSGAACILYAAEPAGTSYWAMEFIACCCLPFGADMTVAVGSILMSNMSRDDEQSVAGALFQTSVQIGQALGTCVTSLIVSEVHANTGDMLQGVRAAFYFCSAFPWAIAIFAVFGLRKIGLAKDVGLGRASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY86</accession>
    <name>K1VY86_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000223">
        <property type="protein sequence ID" value="EKD04502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY86"/>
    <dbReference type="STRING" id="1220162.K1VY86"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_5_1_1"/>
    <dbReference type="InParanoid" id="K1VY86"/>
    <dbReference type="OMA" id="GADMNTH"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="156" mass="17285" checksum="E91DD8CB2FF119EB" modified="2012-11-28" version="1">MCPTINSYKRLLGGEQYWAPDTASYGYDSRAASIRIISAPGVKPSATRFEVRIPGADMNTHYAIAAIYALGLRGIKNKTPLPYGPIGAPGVSRDTITHLPITLERATEAFMAKDSIAREVFGDFFVDHFGGTREVELEQFARAVTDWELRRYLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY97</accession>
    <name>K1VY97_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY97"/>
    <dbReference type="STRING" id="1220162.K1VY97"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030461_1_1_1"/>
    <dbReference type="InParanoid" id="K1VY97"/>
    <dbReference type="OMA" id="PRDNDVH"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="336" mass="35422" checksum="C1B50DAC861DC4C2" modified="2012-11-28" version="1">MSITGKWTKLAIPALQRSSHSLSIVGPKAYIWGGELEPRRPVDTDVHVVDLESGKYERVEAPGAPSPRVAHAAAAVDGKIYAFGGRGGPEMSPIDESGLVYVYDPSARSWTSLKPSSSEYPEPRSYHSAAGAPGTFVIHGGCAASGRLRDTWAFDVFSKSWRRLADAPGLGRGGTALAILGDKIWRFGGFDGKTEAGGAIDSVPLNGASEWSTTVFGEQTGLGRDAAPGGKLEGQEDAPGPRSVSGLHKVGDKLVLLYGEGRPSHTGGHDAAGSFWDDVWAYDPKGEKWTKVSIGSEKPNARGWFASDAGAAGLALSGGLDDSNVRQSDTWVLRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYM1</accession>
    <name>K1VYM1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYM1"/>
    <dbReference type="STRING" id="1220162.K1VYM1"/>
    <dbReference type="eggNOG" id="KOG4386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003572_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYM1"/>
    <dbReference type="OMA" id="CWNELAR"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="371"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1125" mass="120723" checksum="F4B0D44F88152A8D" modified="2012-11-28" version="1">MNSYPPEFLAHPQPLMFVAGLGSDPAPTPSSPPPSGSGSVTSPRTQSPVKQSATPERQPTGDGEFDTLLSDLRQTLRPYQHPARVWLPPSERRQFRVELVDRNVQLPARKAAPGADGRSHSPLSPLTPGSPMNPDGLIAPVWVRKHAESVPAVFVSFMRLYEPPSPHGSAGSPLGQDMMAEAERQAERQADENLVSEIAELRKRLAERGVKLTVVLIASAQTLGLDSRLSNLRRSAGLGAKGSLFVLTPVPAAELPDFVRSLQDALWEPALEYYAAHGKRVRQKRGRVPANIGERGGRSRSGSSAAARARSGSFIRPLGQQGWIVRYDFKAGWFAECRGELDLARRHYEDCWNELARMFGSTTMLPPRTKRWAEAKVLADCVAIKLLLYEGSGSRVMVPFFVHVRRFADLSRGWGIGEETFEFWSWVARQYRLFGEVLELAIRHGFRVPPLPLPQMSTPTVPPTPEVLVSTVNPLHLLHPPAYYFYAAATCTMERKARFDAALAAEQETGSVALAGAPGFANEKGVDHSALIIDLLTKAAALGGPGAAGAGLELYDAYRVADTYVQSGKYEEGARYLTDIVGKFPAWGPITRELQALQLQCVRETGDKETNAALVVQMLAPGWFRNRAKLVKELNTLMEGTAPADPIVVDMPQGEGLLETRAGFRMAEAQAGTPLAFQVQIGSSVDLADLPVTSLKIVFSDEREVILSPGADAFVDVGDMGASGNKSAKAALKFGEGSRLVVSGKISAAEDADSIEVSDVILCIGTNGWTIDVGLKPEPLTAWTTKAGSYAPATGLHSAVEITPRLPSVDIALSHPSTAYVGEDFPVSATVTADAAAQLVVTAVCGEDALRLSHGGDSVDGRLVLDLKAGESTEVFRIVSPRPGECRLTFAVGDATETAILAIVPPFRVSPSMKNIGSQAIVAATLKLGGQRAVQVKAITALGEGKVDDSLEAETFPQSKVVPGLKVVWRPVSETTTERREPSSSSDDSPFLSNPSESTPAETDITTVIALPPIHAPQPDSFLTAEVSQPACVRLNEPFTLKLNVRNSHPTESVWGIVSGETSEHFVWSGPRGVRVAVGPKQTEDIELRLVAVSGVGTLAWPGISVREGDGEEVEVRRSGIVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYW6</accession>
    <name>K1VYW6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYW6"/>
    <dbReference type="FunCoup" id="K1VYW6">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYW6"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_0_1_1"/>
    <dbReference type="InParanoid" id="K1VYW6"/>
    <dbReference type="OMA" id="FMFITEL"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11332">
        <property type="entry name" value="AmyAc_OligoGlu_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="558" mass="63038" checksum="77AFAB5F790FE0ED" modified="2012-11-28" version="1">MTISMLNKNEDPNWWRQATVYQIYPRSFKDANGDGIGDLVGITSEVPYLKQLGVDAIWLSPFYPSALKDGGYDVADYRDVDPRIGTLADFDDMMKACKDAGIKVIVDIVPNHTSDDHEWFQAALKAKPGSPERARYIFRDGLGPNKDQPPSDWRAMFGGSMWTPVGDGQFYLHIFDESQPDLNWDNREVRDDFLKTLRFWGDRGVSGFRIDVAHACVKHMPEGEPLLSWEEIKTLSEQMVEGTLPPNAHPYFDRDEVFDVYREWRKVFNEYSPPLTAVAEGWVSSRRKPLYAAKDGLGQAFSFDLLMIPYDVAKYREVIKISLEDAETSGSSCTWVLSNHDVVRHATRLALKDDGGYLETSRKFLINKGENPKVDPAVGLRRATAATMMMLALPGSAYIYQGEELGLPEVVTMPDEERQDPTFFRSPGHDVGRDGCRICLPWKAEGKNMGFGDGAKAHLPAPEYYKEHAVDVEDKDPNSTLNLYRKALELRHELQCAEKLEWVDSDKEVIHFKRPNGWETIVNFGEKPVPVPRGKVVLSSQPITDSVPQDTAVWLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYZ0</accession>
    <name>K1VYZ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYZ0"/>
    <dbReference type="STRING" id="1220162.K1VYZ0"/>
    <dbReference type="eggNOG" id="ENOG502RYZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383193_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYZ0"/>
    <dbReference type="OMA" id="SESEVWM"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="224"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="722" mass="77382" checksum="BFD3971839F3CFD2" modified="2012-11-28" version="1">MFGNGAGQGPVNPTDFIWAVSSRLPVVEEASPDRSTTSDPSPVAMDPSRPRSQNQGRTVKVSWYRPHGKTAIAPGLKKVTLKVRVNTPSGEATTPSAALDGSASELFAPDGFPATPVMLHLLDVFRVHFGAQFPLVAELGLEAGVENRTASLFLLLAIGAIAARFSKHPLVALTELQPHEYGKVFYARAKAMVGTMLGFPSREAIIAFVLLAHLGFSEDSESEVWMFTGLAVRMSVDFGLHLTPPPESAMSERDRRLNRLTFWSVLLMDYALSFGVGRQTAFRPEDITQTLPSEDDISGAEGARSPFPYAARMMLSYGPLINALNRGYAPGYGGTKVETARAAAIKEYARLPADMQWNVGNLQAQNRARQGSIFLHLHLWMHTILASEYLTGTDLLARRPGKGSGSGSGSKPPSASSDGGNLHPSSAERTAKEVREKGTEKGTEKEKEKGGLSVNGTSVGAMTPNTAAASNLWRHSVRTIGDILVLSDIINPFMYFALPFVNQAWFVAGCCYVKEIEEARAGLSAAPSRAASPVPEIHVSEALDLRSAAVESTEAAGQSDQKEKDGDEKEKEEEDGESSGSESADSRPNVDLSRALLTSVATTNISTLQQGLQKLATYWYGAEWIAGTLRQRIEGIHDVDLGLVRENFASFYSLPDAGIAGVPHARADVDQATRTPAAGQVAAFSGGFTGDLGGFLSLPFDLESGPVTEQEVAIDQVLPHWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ77</accession>
    <name>K1VZ77_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-dependent protein kinase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ77"/>
    <dbReference type="STRING" id="1220162.K1VZ77"/>
    <dbReference type="HOGENOM" id="CLU_2122793_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ77"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="114" mass="11905" checksum="52755B81DAA47E4B" modified="2012-11-28" version="1">MRVRPELALPADSQALKKIINSLAAGRPASEAALLASGGRPKRSDSKDSGAGTPAFGAQSVPESNGTDLEPLPAEAAPPTGGQMLYAGSVDRTASFKAHRDAFFFLLQRELEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZJ0</accession>
    <name>K1VZJ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZJ0"/>
    <dbReference type="STRING" id="1220162.K1VZJ0"/>
    <dbReference type="eggNOG" id="ENOG502S57E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050729_1_1_1"/>
    <dbReference type="InParanoid" id="K1VZJ0"/>
    <dbReference type="OMA" id="GYIPKDC"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852548" evidence="2">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="289" mass="32183" checksum="3B54A5DBABE9DE00" modified="2012-11-28" version="1">MLALLSLCILAATTSRAGESDNELQTRPKIKPYPPGSLNSRLLAGTPEHDSSVKNWTESATLQDAIPLACYDAVKREGLNPADVEVFTVTYDDCSTPWELCRHQDAERNLPTVRSLHSKIPVRARELLPYALHLPGPERAYRTSEILVLGGKPDFLTIMHQVGRAIDDNCGFPGKDRRCSDTETWRNAFDRDTYVVDDIARTSQAENFAQIVIHTVVNLNFPGGLASMGATTDGQFSQNLYDDEVKVQTQYCGPYLVANPDDKCDNFRPKREYVSKSTGEKIEDPFKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZU2</accession>
    <name>K1VZU2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZU2"/>
    <dbReference type="STRING" id="1220162.K1VZU2"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="K1VZU2"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF52">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="519" mass="58319" checksum="B78E31BF74A1738B" modified="2012-11-28" version="1">MTKKEETNHFLLVPNNTASHWWRDSGMRQNVLHCVGCCLCVFYIGYDQSLLSALQALPQWNEYFDNPKGEWLGLIAASLFFPALFTVFISSWISQRFGRKPAIFVGATLIIAGALLNGLAQNTGQFIGGRALLGAGGAMTKVCAAPLLNEIAHPRIRERMASSYYGWYFVGSTIASWLCPVVPFIVMTIIFFAPESPRFLVGKGKHSEALRVLAKYHANGKEDDPMVQLEYNEIVVALESEGEEKDTSWLDLVRTPGNRRRVAMVVLIAFGTNWLGNALIAYYLTPVLRSVGITSPVQTTSLNAGMAMWNVLVCQVAAFQVPRISRRVSFFTSHAGMIFCLAFIAGFSAAFQADPEKNKGLGLGTVPFLFIFYGFYDIAWQILQFHYPTEILPFRLRTKGLALFTACQVGANSFNQFVNPIALENIKWKYYLVYIAINIAYIVYFYFYLIDTRGLPLEEVTLLFDYPRRTAREQAHAEMENRIQAEEERQRGLGKVDADNFPADDKASEERIEVAQVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0V0</accession>
    <name>K1W0V0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase, long-chain specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0V0"/>
    <dbReference type="STRING" id="1220162.K1W0V0"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="InParanoid" id="K1W0V0"/>
    <dbReference type="OMA" id="IEDCFKW"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="544" mass="59547" checksum="EF2C3C134D44A5E3" modified="2012-11-28" version="1">MSKPLKPMTRDEVAQHNKAGDLWIIIDSIVYDLSKFGKLHPGGIGVLLDKDVAGKDSTTVFYGLHRQEVLQKQQYQRLRIGQIEGEEPKIRLKGPSDLSKVPYAEPAWLTPDFVSPYFNDSHRTLQKTGPEGVVVSEHGASQALAELSRSVCGVCSLLCCITLTSDMRKFITKVVAPDAQACEENGKRPSKSVLDQMAANGMNRMRMGPGKHLHGRDLMGVPGEKFDYFHELIVNQEFALCGGRGYVDGCQGHMVIGLPPIMNYCEEPMKTQVMDEVLDGHKLIVLAITEAFAGSDVQGLRCTATKKEDGSGWIINGTKKWITGGTNADYFTVGARTGKHLSVFLVPRSEGVNTKQIKTSYGTTAGTSYVTFDDVEVPNSALIGKENDGLHVILANFNHERWMIACQTIAYCRKAVEECLLWGSQRFVSGKPLLAQPVIRAKLANMIARTEAAQALLEAITYQMCNMDYKKQSAALAGPIGFLKMNASKTLAEVSDEAVAIFGGRGLTKTGMGRFVEQIHRTRKFDAILGGTEEVLGDLGVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2P0</accession>
    <name>K1W2P0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2P0"/>
    <dbReference type="HOGENOM" id="CLU_960389_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2P0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34300" checksum="6FD66F430BCF77DA" modified="2012-11-28" version="1">MTSVDRLRFTFSRLRVRLTPAVIDHLAFPHLVDLIFYYAPLSSLVLMGQTCREWRKRVKAELYHLRDFSAKRKPPWWNNKLSGSTSVIHHYQFTTVRGVSLQVTDTGYIRRCRVLDLGSRPIIVRPERVLRVDTLRISQTPLISINHMGRLGPFSCSRLVLDNHFALNTRREVRKLVVNYRNSNFRAREPRLGPECSNSSFKVHEFVFIVHPTADTKTRGMAQYEAAGLFHKLSASARTAGGAYRGPRKVIFTFVSNTPPSTMVSGKNIRYRTLKMYRAEIGEEEFKIETNFDGPLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3G7</accession>
    <name>K1W3G7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3G7"/>
    <dbReference type="eggNOG" id="ENOG502RV8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718024_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3G7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="385" mass="43367" checksum="87A48817EF07A775" modified="2012-11-28" version="1">MTSSQGVHDAGFTALPPELIIAIASHLPRPDLARLSRVSSFYRSVCVKRLYMEVEDHVIVWPEHGIVHLRPPLNNPDYAKHVRCLQVSARPEGCCRLPPFTLPHLDVLRVQFGSQYHIYGDGAPEFASADAYTPRTLVMELPNDPYYSDFPMSYLTSRMKSTQLVLLLRNFGFADAAVSNFTPRCTRTVTIVVLLRGRQCTLERLVTALMSICLRLANQDCTPFQYHQLQHVRFVIGGMTLSRACYDQLLRSLLKHIKRYSYYTGPDVPAQYTAPESASTTASDAPKLQHGPSGDDTPYDYADRSQRPPPTIEILSMDEYLSLGSSRYVLSEDDLKDHREQVTEHVFDDAGAVAKIKKQVEEYQHVGMIMRPMESDLSGPDGNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3I9</accession>
    <name>K1W3I9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3I9"/>
    <dbReference type="STRING" id="1220162.K1W3I9"/>
    <dbReference type="HOGENOM" id="CLU_300940_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3I9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1016" mass="109035" checksum="6B363BFAB9BFA1F7" modified="2012-11-28" version="1">MSRPGGSGPSAPRVPEDGAALSVRRLKRIAEDGPPVVGTIKRPRGGFARNDSGLPPSVGFAGSSGGGGRGRGRGRGGSFNHGGGNNANRGGHSHRGGPHRGRGGGPNSFRGGRGQPGGSRGRGRGRGRGGKGGFQPTGANAEPQTDYYSTGADLYADYADVGTGEEAHHGHEEDHEPQSPPPAPRIGRPELTDSYRPERHALPPRPAVRSPGGSPHRSMPPLSSPPRMVPPSTPAQPTPSRVSLLSSSPVARFHLDSDMVFELASEADHADHDEPPARKEKEREVRRGYGEYTYSPSSPLPELAASTHDDGSWNSALGLTTAPAPKPAAADKGKEKEKQPTRPPLPPLEKDDKLAPKPLKIKPMNRNVRKNDPPKPPSLALPKEKEEARLASKSPVVSRPPLAVDSRSKSPMPSQAVSGASTSAMPAASSSAAPLTSTASSSSIINIPPPPRMRTPEPIELSSSPLVATSSIPGPAPRSPEDVKPNLALLAPSSPPPAPAPAASMPREGVLALRRADLPTDCFSTDRIRRVPARHIVAQDAKARVVAEGKIVLGTRWRDDGFCVDWQLPARPESDSDDSDDSGVEFVAAPPRPPPPVVEIIDSSEDEEPLARKPKSKRKGKSKRRSEEPGQSRDHSAAATTATTLSPTRSPPPRAFARVPSTGTQRGVDSSTLPHDPETPESGPAPLPLLDSDERDADKWAEYVAANPNGSIVLPFPVKFQKEDSRQTRGYVKWKERQLVLFRTYRSHVASNEVTSAETDGKDAWAPGLRVRWRALSEDEISAAIEKRRREKRERREAKKAAKEAKEADRRSASVRPREPSEPHQPEQRTNSSWVAAQDPRPIEERDELDEEESKDDIAERAARQEKEKERKKSDRAERRAMAKQPQDSAPRPSASPAFPLAALPSHALPAPTPTPLVQPSALSALPAPAVGSVPSPPPSPLPLSETSPEDAELARLQNEISAALEKLDRWQRLKDSVPGKVDVVSAQIEQVTLEVFSLQTEYERLLDAKKARRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4R5</accession>
    <name>K1W4R5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W4R5">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4R5"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255949_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4R5"/>
    <dbReference type="OMA" id="KTEPFVE"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1267"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1311"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1358"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1397"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase MARCHF6-like C-terminal" evidence="12">
        <location>
            <begin position="1254"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1493" mass="163803" checksum="1A9ACFE3A69F26B9" modified="2012-11-28" version="1">MVTLRTIMVAFNIAHHDLNTTLQYNSTTANLTGRQTVLALVAGNGTYADIVPSLVSRYNADFSNIVPFVFRGQIVAISVAAGLIGLILIREWIGQLDWQPRPAVEEEGELRPEDWVFRNGRAIRKTDYDFTRPRRRHRHAGTAAKEEPAEEQPRGRDTLPPPRIEIGQQQFGDDAHPPPRPSPSHVAFAAPEQLGEEPFWGYVRDNDKGKEPERSNGTAEPEAEAEAGPSRPAADVPHDVSGSTTPGNKDLGWRLQDALENPEERSYGGPSPGRPGYESPHGTAYPQSPPNGLAEPSTSATEEAYSEHPPLEEHDSLETVHSAGSGPDSSPDFRRASDPGPPASESPRPPQRPYGSSSGFPVEIIFESPPTSPSEKTEPFVENGEPSSKVLLDEATVDSPAPATPAIIHTPADDQSPDGYPFHPLEEPQPEAGEAIDHSAGSGPDSSPDFRRASAPGPPASESPRPPQRPYGSSSGFPVEIIFESPPTSPSEKTEPFVENGEPSSKVLLDEATVDSPAPATPAIIHTPADDQSPDGYPFHPLEEPQPEAGEAIDGELDEWTDTGDADAEVDGDVEGLEDEVDEIHEERIRDLIVAREAMANPLGARERLAEIADLRAEIDMMAAGDLAPEDEDDRPLDADDWDGILEVIGFIGPLTGLVHNHIFVSMAMSCTLTFLVGLPVAIGKLFLAIDPVRGSRDLSLLVLRSLVFVADGLLSLVLTIAREILNLPRLLVRPASQILGSMGVQFNLTDPTINLPTHFLIRSWDANTTIVPDFPTGATPAGRVFDGLEFLGNFCFEAYKAVRLRFVSVAASPAVMDQFWCLVTGYAVFATFLITIAVLDTAHLLNINAAIMERARDVQVFLKVLFFMTLEMVMFPLFVGIVIDLCTMPLFGATVASRIAHYGHRTFGSLFIAWLIGSIFMFSFAAFLTHMRTICRQGALYFIRDPSDPAHSPVRDIMERPALVQLPRLAVSAVMYCVIVFTIFGTMPYFMWALGATTSLFQGVLPLRLEQRPLSSVPFDLLFLHLIVPPSWEGLKVYTHVKQGLAAWWLFVVRQLELSSLVFGVNTGNRPMSRFSQLGWIVADAVCQRVFGTYDNRATPARVPNSDRIELLSLSERRKEGMFILLDSNGAPRTPADEIRLLKQDRAARRAGRNPKRDYTVVQLPEFWRTRVYALFASAMLSAAAVVATVVLVPLCVGRMATNMVFHEQIYDGYNWIVGGYICWGSYALGKDLQRRIITYSRARRIRKSGTSTRAKRVVLARLSNAYALALLYFAFPLLVGVNFELFIGVPARYGLARGVTPVLHLWDAWAMGVAFISIFVGVIGFANEGGNLPLAERLRDAFKHPLHQPFVQLSEFVLPILAILLVPITVPWAVFLGVRTALAGLGLAGFVDGTAAFRLTYPLLFVPSAAFLLRWPLRRLLSRVRQWMIDAEYVVYERVENYEPEADDGGSEWEDVDAEADGAMRLDWPGRLGGEAGAIELGGPPPLEPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W558</accession>
    <name>K1W558_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000235">
        <property type="protein sequence ID" value="EKD04063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W558"/>
    <dbReference type="STRING" id="1220162.K1W558"/>
    <dbReference type="eggNOG" id="ENOG502RZR3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013668_0_0_1"/>
    <dbReference type="InParanoid" id="K1W558"/>
    <dbReference type="OMA" id="AFMHRRT"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="945" mass="103547" checksum="5040418F20FCDDA2" modified="2012-11-28" version="1">MNPAASQAALISANGAANSSSSSSSSQVSFDVLPIEVLSLVASLVSPPFYLPPPPAEPSPRPPAHIVESLDPKPAPQQTSSQAVSALTKSSAHVLEATRPWLWENVDVRSGRGWLAVVDALTEEVVDAVEDEVVHHESVFVDTPPSPRSPGQSPGGFRPHHHHHTSPDVGTSASAAAAAAAAASQQPSQPVETMPSVPVGTAMRDPRENLGLMRSVTINENVAKAYYSDKGWTHERTRTMSPPQPRRLSMLITPPGSRNTSPSARLRGRSRSPRRNLVFEEGISSVLARSFNQRSFSGSLPPGQRPLMRQSSLSLSRTAHALLEESDDEDCDQGNHQFMQALRTPPKENEDLPKVEQEEEAHENANPDLLPPPGPYIRHLSFTNFRTIGSRRSQDEAVRGRYVTAGRLEGVIKNTPNLRSLCMTEYVDSALSSAVVEEIFFRGYSKPRVRKNRAASFSSPQARARAMSIQQEPEPAQSTIDDLMDPPRPSYVPYEEETEDDKWARRRQFQPLESLDLTGCVSDNFTDAIHEFGENWLGLGEEDEDEDRGRGRSRRREDDDEDEDDEMDEDEVPEQRHRVSFPALRRLSLRTCRRLPPAFIHALVLAMPNLTHLDLSGTRVGNSLLQALTHSPPRGMRLESLSLARCPGLDPTVVVDFLLKSPVAADLVDLNLFVNPTQGNAIGSEDLMRLLEAPCFRSGRLRYLDLSSAGITAAHLAPDVFPPQPSLVSLGMSHIPLLPLRDVASFIQTTAPGVEVLTLAGTAVHDLRPDASSLQITLCIHALLINPLTTMPFSISGLNLSGPSKADLTCGPTRLRVVELSSSIRRSLENSQGASRTEWQVIRSKGGRGWYVDVSAGWIPTSTVSDWGYVTQEPIEVGEGMGAMSFVRHLPNAHSWRQWLTRLAEANGRVSSYVGWHSRKMEVVRGEGMMGREDGMGGVDAFALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5M1</accession>
    <name>K1W5M1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5M1"/>
    <dbReference type="STRING" id="1220162.K1W5M1"/>
    <dbReference type="eggNOG" id="ENOG502SEGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062265_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5M1"/>
    <dbReference type="OMA" id="CQNANTR"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="389" mass="43701" checksum="79CC85BEDCE84789" modified="2012-11-28" version="1">MLQSPQEEPVLRQLHSGRHSVIKKNVQQQVDVAVKHAEKLLEGGHNHSRGAQEWRQLRAEVAAAEERVASLRRQLKARTSEVKKVIENAKRDRPNAADLRANIALVRSKQHEVGKRIIHARRVLVREVVDVFGVQRRRSWEIAGLQLPSSPELFRLEPSLHINAIVLHIIHLLSLMTRYLSISIPFTPTFNEQEHVGRPYMIANLPFLSTTKWRDKHLLWMSSKAYVSKKHAGSKQEKAQIVLKSYKKHKHFLESFALLCHSVAYLAFTQGVLGIGIGPQSFRPAPSNRRKSSDENDSPRFLPGSDGVLVSATSVLELIALTAESPTLGCKSHEPSTSDTVKHMGFSLDISEVVASVLTCEHARWGASKPDVEGKEHLSEGWEVMDMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7L3</accession>
    <name>K1W7L3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_00824</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7L3"/>
    <dbReference type="FunCoup" id="K1W7L3">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7L3"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="InParanoid" id="K1W7L3"/>
    <dbReference type="OMA" id="KLERMCN"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="15">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="162"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD04878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="412" mass="44445" checksum="2353CA5863755EF3" modified="2012-11-28" version="1">MLRSRTLRPQTLSKITQLSRTMASAAVVPPDVQPLSEAHQAAVLATVPALAEHGLTITKQMYKNTGVQPAALAGSVLAYAQNIKDLSPLTPVVVRIAEKHAALGVKPEHYPVVAENLMGAIGHVLGDAFTPDLQEAWYHAYWQLAKIFIDVEAGLYEKAAWQGWKDFEVRAVHNESPTITSFELVPKDKSMLPLKPYLPGQFITLRVNVPELGCYQNRHYSLSDSPSGDHYRVTIKRETGADAAPDGLVSNIMHGLKAGDTVEAAFPAGSFVLPETVPKNVVLIAGGVGITPNLAMLNQLTAGPAENWPQITWVHGVRSAPEHVFRNHVAKLAEQSGGKLTQQAFYSNGDDGANTGRITVDKIKDSLPLADKDAVYYVCGPGSFMTDIERDLIAAGVPKEKINIEAFHAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7W0</accession>
    <name>K1W7W0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7W0"/>
    <dbReference type="STRING" id="1220162.K1W7W0"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_1"/>
    <dbReference type="InParanoid" id="K1W7W0"/>
    <dbReference type="OMA" id="AWDENSN"/>
    <dbReference type="OrthoDB" id="2584499at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="134" mass="14637" checksum="585531052747D0C9" modified="2012-11-28" version="1">MAVTLARTTITGIAPSRAPKTVGPYVHATVHENTVYSTCILPIDPKSGQLVGDTAEERFRRIYQNLSVVLEEAGSSPQRILKQTLYLTDLADFYAFNKLTVEFLGDHRPARATVKVLGLPLEAPCGLEVIAARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>K1W965</accession>
    <name>K1W965_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W965"/>
    <dbReference type="HOGENOM" id="CLU_1195605_0_0_1"/>
    <dbReference type="InParanoid" id="K1W965"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="232" mass="25613" checksum="B9698F94903C7949" modified="2012-11-28" version="1">MSTYPASQVPVTTPTAASASSHTQLLAAPAVRVVRYQVIVPWEVVRFVYQSGYRALRMCLQERFLLFPLATAVEVEAQIALQTCDTINHHDHSQVISRFLADIMNCQTAFKITASTDSNAPLAWFVTLVLPKGPHGDSHSSQPRQDLVASPSELAQEGAEMEALLNMLKYVEPEMYKASNLLPTPFDPELADRFANQLGSRCHGAERRPLPTLVSQQTVDEAMDEARSFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9Q8</accession>
    <name>K1W9Q8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9Q8"/>
    <dbReference type="HOGENOM" id="CLU_1662048_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9Q8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="18524" checksum="E2C5EEBCDF0E7441" modified="2012-11-28" version="1">MSFTQSYYIRTLRKLHDQELRIEYRAAEKRSRAEYRYWKSIRPLRSTSTRYSSYSGHYGPTGYTSAMYPSHTGMHAGANYGHTGHLPSMGGIGMGGMGGIGAHGYPVLPRDRHRLARAQQKYYRRCYEIENKRHRDLERIQNRREQLLGMLNGEFRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAV8</accession>
    <name>K1WAV8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1WAV8">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WAV8"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245514_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAV8"/>
    <dbReference type="OMA" id="HMHISES"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="1108"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="918"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1355"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1355"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1404"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1489"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1505"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1535"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1570" mass="171572" checksum="5D9CA6FDC6F7E227" modified="2012-11-28" version="1">MTTSRFNTRDATARGTGSGVAGIAKQTGALDLGPAGTRSSLEAGTHQVFERRPSNTSVHSMHSTGTNHSSSTQQLRDRELAQSPASVSSSGTLPWMTPREAFNQSPQFATSSLPALPTVPGSVQAHPTQPGPPGGMARPSSHTQLPRIARPPSIDGVNDMSSPRSAPSSASPLSQNAQHGPPFMQPPPRSTSSPDPRLGPDGPGSSRSSPVTSPRPAASIPPYAHMPATGAGAGAQTNFAVPPPRVSSFTNAAALTTGSGGSDGGITPRRSETPTSTTSSHAPPGSAGQGAVQNYQPTQQPTARRSGSVTYCAKCGLAVRGQFDCDKVVAQKFFPVEDNEGRQYPLCERDYFARLDLICAKCDQALRSSYITACGEKFHVEHFTCSVCDTVFGASDSYYEHDGKVYCHYHYSISFANKCVGCETAILKQFVEINRNGRDECWHPECYMIHKFWNVRLASRNFTTPASATPASSSLSLLEMSSMPGAMPGMSPQSSLSANASPGWDAEMSAKDLKERQIAMELKVSQIWLVLSGFEESSAACIGDMLRVVNERKLLDVILLAEKFILHVETLFAVIDDLEAQFALAGVKGMSHAREAKQLCRKLVNFFSMLSQISPHANTIPNMQELLTQVTQLAHYLKILIRIALTGAIKLDREQNNPKAMTNALARLHLLSLDNAEPSLRKRGDHPNPTPPSDEWNGNETAEEMAKRSYDLLSRHPEGFIPSTKEIAYGYRSLASEVTGETTIRGPQNDTFVPNDGCITCNGAIEDDCVRLGMFNRWHSMCVECGKCHDKAGIHHDQESASDRTAELGSEGTHDYMVKAPARRLPPRVDDFCFEPPKTQYGPTDIIWCVTHRTATAETGFQSVSRLEQFAFLLHVALRRLYLHFREHHKIPSALTRSDASTDVKRVKSVTLDRKLSSTARLPQRSTVVESPAGKMADENGQVVPARSPSGSVPPPTIEEGGSTESGVDVLRPAFARNNTQIRIVKDEPPTQESQNTELSNMMLAVPQAHGKEDDAITLSDIPTLLANQQNQPRSALNSVPLFSQLTPLDASIVRHFALINLTKTGLGHLIDVDDILELLDTRKNQWWNKIFKNNGKKDQKKKGIFGVPIEVLVHRTGSDSQQGSNPTTTLRVPEFIEDIVSTMRQQDMAVEGIFRKNGNIRRLQDISDQLDKDSSIVTLSEENPVQLAALLKRFLREMPEPLLTFRLHKLFCAAATLPNPEDRKRCLHLLVLLLPRANRDTLEVLFVFLRWVASFSYRDEETGSRMDIANLATVITPSILYAKSGNPAREDSMVAINAVQQLLENQDDIYHVPLELMFVRHDKVAQIFANYSDYLPPKEMHKHLQNYLQRRYPQGNQSGQHQRQPPPPGGGPHMARADSNQNQPNRPADLRLSSLPPPHPTEGSASGSLRAPQSNNNSRPTSWGAVAPPPGPGTPGSSGLPPVLNGNAAQGQPFGPPGGQQQQPAMSMPMPAPQFRGGPFQGAERNGSRQSSRGSAPSSPGLPEADRRSFQMERDRSRERAWTPSEQHSQGHAQGHPQMSQQSHQMSQQGHGMSQQSHQMSQMSQAHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEG4</accession>
    <name>K1WEG4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEG4"/>
    <dbReference type="HOGENOM" id="CLU_027594_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEG4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="69849" checksum="AFF83730943F4E68" modified="2012-11-28" version="1">MSASLWFYVSPAVRAGVTDLERQSRERNCPSAPVFEWIKGLLNEATAANKVDRARRACLSPQLPPATALLCLRRFEQREPLVGMAGLPKGTCILSDTGVWPFDLQDSDGAVHWVIRRAQEQLSLQCLPEDSAAATFPRAGDVAGTRFGPFNNVGIVVDLQECNDLSPELARLSVPTREKWHRYLKRSGPVDIARFPPLNHTVGVMVGHEEFTDEVAMDVYGAFSCTVELSVLNDLLPAFDSTSAADCKRLPSFRGAVQLSPLNGATVLLIACCLLQAESAVHKLLDMDVTGMIILHDLAEYGLGWIMHERDMQGIVTRWLQCTDYYIGNPPPVPKLSLLLKTWMTRKCGLTIAGRMNTPMLRYREVEILAPSIDVGSDAKHSSIRSGIFCGSACGAAIALAVCQLSLDADGNTPAHVDEWVEKLIGTAQATTSNTLLTESAAEMCKGFLEKSLHGATSQDLKEFDQLRNEAMGERSSASGNGAGPWFDQHFYRAFFVSLTDGRIRDTGEGPLEWGNALRDETELRRRALIGVSCDHGSGNATADVTFRFLAVFAISLGAVVFLSSYSHLNPTSDIPLVTTQQELNMTMVKGISRLTQSVNVGPGLALKRGDLVYLLSDNLGSWCKVATKEGAIGVSATLRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG14</accession>
    <name>K1WG14_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG14"/>
    <dbReference type="STRING" id="1220162.K1WG14"/>
    <dbReference type="eggNOG" id="KOG1245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002631_1_1_1"/>
    <dbReference type="InParanoid" id="K1WG14"/>
    <dbReference type="OMA" id="YANKMGE"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDT" evidence="4">
        <location>
            <begin position="228"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="763" mass="86931" checksum="7E91F47FDCA83D4C" modified="2012-11-28" version="1">MSTEVFVDVQGDKYLARVVRTFPPKDLVLPEGASSPYHPYATDLDLEPEVVVERDDPMKYFYQVRLIEEGGDDEAQPSDTEEGKGEEFQGSVMEVQADKISRDAAVFSPWIVKKPVALRYGLPTEMSDEIREKIDKIRSSEKTRKKRERDARLGITHSEGEEDSKPEKKKRKTKAEREKEKEEKAEVKEEEKEEEEKKKKRGLKYPCEDATAGRIEVRPKPERSLPFGDDFDKFLFTWSFLNVMGKPLGLSPFTLDDYEQSLLHTDEYTAPAPILVEVHAALLNALMKDLEEGHEPVKPIVHWGLDYDNDMDYWTGTKGANVDTLRPVVEPLGESWTKRQLSYKDGRKGWESALVGCLWERADLDTLKDYLNYILHLTFEDKPAPTRPTWSTGPSTSSSHGLIPSKPERRYTSLDHKAKLNIISFLIDLVTQTANIRDFFEESTNAVTEDALEPKKEKGEDGEDVKDEVPSSVAPSPNGHANGTATNTERDELEGSMMDDTSRANSPASEADRVRTAASRRRAMKEKALEREAEEAERQAALLRERAEAKLKRAESKHMSQEKKRLADAEEDLENRQRQLDYEFRRNNQVLRVKPIGVDRYGNRVWWLDGIGSAGLYDSSGKVTYGTGRLYLQGAEEFDVEHHRAAAELTEEQLSQRRAKEEGDNVLAPGEWAMYDTLEQLEGFKNWLNPRGYRDHHLLRFLNQWWPEITQGVQKRRAAAGLDGNEDEGHGGRRLRPSRRAAGDDVGEGYLGWKNRRAAGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG21</accession>
    <name>K1WG21_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG21"/>
    <dbReference type="HOGENOM" id="CLU_874893_0_0_1"/>
    <dbReference type="InParanoid" id="K1WG21"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="318" mass="34104" checksum="CB8C4A1C623AF2A4" modified="2012-11-28" version="1">MPYPIPIIIGTTIAAVGTAYCFKKALVAQHRAQGAPGYNPISSTPVASQASSGRSSALDNGAEKLRRRHPAEMYELDETRILQDERDAPPPPYAVRRRHMSRKPIPTPPTVQRETTPVAAEKVSAQQETEKANILISLDTAAQPAEPAAVVEKAAEPAEPLVAAENSRDMEKGSKVERSPTPVRSGAASELFMPMPQAARPSIPQILQDEALLSPSTVSSVLSSPQLLGTSEFGDDDVISLSGVSNNTASYVDAETYTPRTLSPMSPSDFSVVSSRAISPFISETEVAPGMAQVFSQSGWDSESHRSDSEWEVLSNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG81</accession>
    <name>K1WG81_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG81"/>
    <dbReference type="HOGENOM" id="CLU_336218_0_0_1"/>
    <dbReference type="InParanoid" id="K1WG81"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="848" mass="90156" checksum="AD86F29FA3DB625F" modified="2012-11-28" version="1">MDSLKGGAALDAAQHHPVHVAHGPQASTQQKNPSPHINCSPPDYWNNCTHSADDADESATPDNNQHTMILKKAVRDILDHHPIVVDAQRVWSAPASYPNNRDRATAMLSAWTQNLEHQLKFLTSKFVPGPSLVVDGGKPVSFYPVPGTFHLFAPTNTVPLSRRIKYGLQKADWVPTPQAPASFAPKPGLPPSVPSAGSNNVAFANAVNEEQSEAVKVTGKQVKVTGEQFIPTLASDGSLIPVYDWDAICAAGIDLLSLTEKPLFSYEYVPVWSATKRKYKFYAQKTASPPHPLSPSGFGPLGRFDPLQLLETDISQELYSMSCTGYCWLPDGIALILSGRHDLYRHLPQGPNAKRFNATSPCAHYLHPVYDGPIPNELKGVAYFELQLWNRGGSASCDSGLTASASVVDGDDNTGSAGQEASGSRSAPEKASQSQQSADDQSWGDDSKESNDTNGNRGNSGGQGSGGSPSEDEFDSDDSFDSLSSSSDSNSDVEEEQPLPPRRLPPASEIRRAIHRRLPPAFTGPFYPRRDIPPRRRSPLGGPPITPQDLADASDTDAPEEGTPNLRRSVSWPHLGGTPSSTGHASSNNLAPLRRKKNRMGKQFARLWNDRQLLPPAIITNSGTVPPASGGGSTSRPADASIANLEQSESLTVATTSDVNSPSNRGLLRHAPMSFTTELARQLEQAVDLYASLIGPSNGVRPPARKVPAATSSHQSAGAIELPSANVVIAAGPPAAGPSTTGPSIATQAVDATDDSVDDAIPVNPHGLTYPPTNPTPYNSPNLNPTTAHSAASDSSGAGSFILVEEDHDPQCEVAVHRLLGLSGGECSCWSLVDRRPSDPSDYDGDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGW7</accession>
    <name>K1WGW7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGW7"/>
    <dbReference type="STRING" id="1220162.K1WGW7"/>
    <dbReference type="eggNOG" id="ENOG502S731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025399_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGW7"/>
    <dbReference type="OMA" id="NGWLIFM"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="62980" checksum="FCD9B31C0A54B5F0" modified="2012-11-28" version="1">MTFGFTQTALVYSFKLMTCEDYYLDPTHLPPPTGDACNVPAIDASTAKSVAMMSSMTVAGTIVNLFTSAWVISRWGVKAAMFQQTFWAALRNLCQIYAQVTGGRAGIDITIGTQVFNALGSGGGFQLCANSFISILAEESERTAQFGILSGVFMLGSGIGFSVGGVLFNYVGRLAPFVLAFGFLVFCTLFGALFLPYIAPEHKQEKKPRQSILAPLAVFLPTRKPEGGGRNWAMFFLGLGTFLSVLATGYIAMALQLVATNVFGFKPDTSGYMLSLTLVVRAFFLSVCFPKIISWGRRWYIDHPSPAATPTTTPSTPAQRGKQLPSSPSTPATPRSTKPVETTPSETENGLAVPTKNGAARSVSPARTSSAHSSTSGETTLVEEERDADGEFELVLEPTRVPGAKFDLLFLKYSILLDGVLTSCVSLANRAWHMYAAAVVLPFASGTSPAVKGVILEFAAAALPPSYDEDGEESAPLLSGRSGREGEGGEGERGRERGYGATDVHAQEQRKEGKHGGISNTDKSNVLSGIALIEKFGQVITISLFSYFFALLSEANRPRLIFALDGIIAFLAFLVLLPVQMPRPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH66</accession>
    <name>K1WH66_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH66"/>
    <dbReference type="HOGENOM" id="CLU_1563994_0_0_1"/>
    <dbReference type="InParanoid" id="K1WH66"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012113228" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18357" checksum="0FD0EE68CC737B3D" modified="2012-11-28" version="1">MKYTLALFALTGALAAPSERRQQPNGGGSVIPSTIRLEGTNLCVHAHQFISEVVDSVNLQMCQVTVEDNDKNGAPNAPDQGWISTEQGTEQASYPGWCLGVTGNGQAAIAQCGVESDEIRSSDIVFNGQNLCMAGTRECFAVRQYDDTAGNLFLTDDTGIFANFVFPYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHQ7</accession>
    <name>K1WHQ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHQ7"/>
    <dbReference type="STRING" id="1220162.K1WHQ7"/>
    <dbReference type="HOGENOM" id="CLU_392862_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHQ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="702" mass="77478" checksum="FCBDE6A8DA3884AF" modified="2012-11-28" version="1">MYSAFFQRSTSPEHIDPRALEVLIDQAVPRYSLFGRTPIVAIGKDVPHEEFRHEHAGLGYRQRLAGPGPQATNTALLQQHGVDPFVLTPEQKMAILPPFIDMFAVISHCQTLPEQSAEVASAFVNECLAQVTQFGDTQAFYDAREHVPSAPTGSTSKHSVKIHEYAGTAVIANLGENRYAIVLINVDRGEIKYDPLPAQDWCQLQLAADAANQCRMCAYVSCIRTKYPAGFALRRCVLRDCATWSWALTCASVCAHGQRICSMTGREGHVETSSGTGKALRDPKGHIAHTEADLMSEGTARKRHPGGTLSCEVIGLVDKSLTRDELQVLEQLAARNVALNHAREAAAATGDALQVVNAVRQQRGERILSASDLPRLATLNSVLVQVAQDPFGPLPTAYATYVATVSSEDVTTVNGDERGRFDLYERQLGFPDSATLLRRLQDAAAHFPAFRPRLHVLERAVMARMDIPGPAYLYYAGCSVSGTPESRASNDFQQGLSFYKQLVRFWGVESVKVYRINLGQVVVNPYEYRANRELQNEEHTLISMRFPLCLNSAPGGFNHEFSVDRFPAKPLPRLTRDPVPPAMIQALQRHFRGMYSIFAEKTRGRGIDPAALDAQIEMATPRFTVQGQVPIVAVTKDITQEAFEHRHAELSYRERLAGPGPHLANAALLHQHGIADPYGATTEEKMEVLPPIADLFSFFGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIS9</accession>
    <name>K1WIS9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIS9"/>
    <dbReference type="STRING" id="1220162.K1WIS9"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299756_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIS9"/>
    <dbReference type="OMA" id="DCTYEND"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="146"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="913" mass="102758" checksum="374B63516AB3E34E" modified="2012-11-28" version="1">MRNLKKFGGGKAAAAPKWKPDWDWVADVKDPKDITPELRRRAAGLADVPPCPLPTVRWASRQPSTDGAGSSTSSKQNGVIDVDDDEGEGSSAVSIVSPKSNGPACTAKRCKSSPRCYNNLGFEKDAKEKYVENNAGEELEFRDGPAGLCNYGATCYLWFNNVAFRNGVYEAAGEHGTLHCLASVFGRLQISRRPVVDPGPLIEALRLNKGDQQDAAEFSKLFMTLLSDEFTRRNPQGNLVKDLFEGEMEYCTRCDTCGYESKTSGTLRGEGRQLTIAPFLELEISLKDKASLESRIDHMLQSERLDGDNKYSCPRCNYKLRPAIRSTSLRKLPPFLHFSLMRFVYDPRQDSRKKTKHSITYPRKLQLSDTWYELVGAFHGHFTCEVYDEQSKQFFFYSDEQVKRVADGEGRPKKRIKLETDDDSESSRDAYMLVYRKMGEPLATAQDPPPSVVEAIKADNVALAAEIDGRVNKTSELASQFDSVQEEKLAVLSEIDGGDCIIPRDDLKTWIESPELATAWKGFEEVMCKHQRIDPEKTKDLRLVSRSAFDRIKQVNPDIPEVDVCATCVEAEFTRRTQRSNKEEQVKAFEELNPSSGDQDYLLPRAWLKEWKGKKGIDVPPTDPDYDLRCEHGQLYVPHTSLVSNVTAEAVALLQSIFGDFPVFTDNDVQCDECAVSEAQKQSDYHEWRARAADEKKLAKNQLNITQILGIDNYLLPKKFFAEWEAWMRGKGADRPEGLSMEYCPHGLLDFDPQMEHSNYITAAGWNELCRLYDHDPSDAVKVQFSASPEEGKKCSVTRGKDTVPAESKNKRRASARSKQMYVDVEKGTAIKDIRLHIYEQWKISPLSQRLFLRGNEVDASDTVESLRIVEGDWLCLEEIEEADDFGPDGGTEGFGGTALIGRKGELTTRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRM2</accession>
    <name>K1WRM2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000244">
        <property type="protein sequence ID" value="EKD03634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRM2"/>
    <dbReference type="eggNOG" id="ENOG502RBGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095428_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRM2"/>
    <dbReference type="OrthoDB" id="2560253at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854915" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17892" checksum="19AFECA6AD418CD1" modified="2012-11-28" version="1">MYLLSALLRPLPFSLSFLSPVLVLLLTLPLVPSVLAIPASEQFALSTQTQASACFIKCHNEFCDIHDMPGNTKNFPSAITINCGLARIMPRCLAVTCVSAPDVAYAVEYGRHFCARAGVPDVKFEMPERFLLSEGGAYYNDSIASSANRRTPALAAVLAAGTLALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRN6</accession>
    <name>K1WRN6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000243">
        <property type="protein sequence ID" value="EKD03639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRN6"/>
    <dbReference type="eggNOG" id="ENOG502SCVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227066_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRN6"/>
    <dbReference type="OMA" id="REIDIFC"/>
    <dbReference type="OrthoDB" id="2574995at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="944"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1018"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1090"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1415"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1787"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2318"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="2461"/>
            <end position="2689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="44"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="423"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="2193"/>
            <end position="2204"/>
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    </feature>
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        <location>
            <begin position="2502"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2525"/>
            <end position="2536"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2551"/>
            <end position="2582"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2587"/>
            <end position="2599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2749" mass="293328" checksum="2C80B36966681AB0" modified="2012-11-28" version="1">MVRDVRGPSLAHSPSFGVLLERKSLPNDSVAGPGPSSRPMSRSKAGSSSKATPRTSTMPSGRKLANLLSSEANDTPVVTKARRYRQSTPTMMRADETMLYDIAPPPDMPSSSLFGDESDDDTATSPRSAKGNAVMGRGNMLTPVNSTLFPAPPPPARLSVSRSARLPSPESMPQAVNPANLKASQSQKRTSTPKPSSSQRSRASNAPADAQGSAVATPIASQSKLSQPPSVSSRRQPATPNASRHATPPRPLVAETAYFRRTLTPIARKALKGKVVGCMEKPIHFEGEDPLLLEPELRHRSGSMTPGSVARTKRTPKTAPAGRKSRTKLKAPPATSVAQRLFVRPDEDSAPNAESTPDDDSDDDEAGNDTFVDIKKRRQPPQRSALGSHPPLNASDLKSSDTVGEEDATPKRPSPLIDLGRFVQSNSGQETAAVTTYDDEMPLEEAWNEPLFLAGSPDSSIGSPLPQSRDPSPVRATEKEEPVSPARSLSAPESPPFPPSSPPREPSPVASQRSSPALHAPTPTLGISSPMRPPPSSPAVIASPAFPPSPALRAPTPGGPNPSPLKARESLRKSVQVRSHAGKRLSESLRSPSADPSEPPNGKVAQQSRPSSSRLQSPFAGAQAEEPVGSPRQSMKNHDHGNSSDESEDNFNLEGDTVIVADGEDSLELQDTYVNTQEADAMPPSRPPSEPSGASGPIRNGSSTESLQSSNSDAFPPSSTKAKAGRTARKSDASAAVLRGASASPSSSKKSSRKSRDTGPAPAEDGGASDRARNAEPKQLTQDRSRPPAREGTAEDPLLLEPAPRSASKMTATHSRQNWLDSVRARSNTPASPLAKKKSGEPVSSLDHFLALDPASEPQASHLAPPQPSPRPSPQPSPQSGKHQGATADIPRPRFSMSPSMARAWRPQGDSEASSRASPPLIHPVEAVHGFEVGLEDTVALPSLDVSNAGDQSPGAGAPFDFSVDGPFSDNDDSEAEDAAIVQVEHRELPIQVQDEAGLEASFDLSADTVREVDLSADTVREIDIDDEASGGSDPTPEEDGQELDEQAEHAGSEPAKSQSRSPYVADDSPLADVVNAALDAGMVIDSDAQGTEAVNVELERQEASPAPSTPAEDSSEAESDDIPLMPSRLRRSLHAGATPMRPKILSAKVAPPSPPRDDRPVTPVRAPRPRVLESAGRTPSMVPGPPSAVASSPFVRDYSSPFMVKPSASPTSSAAKSSGGRSTRMQPEIVVEPSSPLVSPPSVTPKSTHTRATHSIAQDAGVVIPRRDVEPQGQTSTSSHRQPPSPPSVLPTSTERAVRPLPIRKSVTPTPTRPARVSATPIREPVSVERTVSTPIIAPTPRAIKPLPHRGVSVTPRAPQQQHDAPPSGPHLHSQPSSRASSRARSRSPLRSFSPKAIGTATAIAATALAVAVPAAASPSPATIRAQLSPEPELSPLAHSAVSSQRPGHPHLDTYRSPPRSSRSSRLSATPSAHSTQSERSRSPYEHQDHSDHASIANSRLAFALAGLSDEEDDYLPEPPVISVTPFFSRSYDRAPSAASQSSPAATPRHNPTAAAQTNFGTQRTPSVAGASKEATPTPRPEIKLTTPRPLAKEGAAKGTPLARDQPAPTTPHLRVESQSNSVTPLPRARAATHTPQSSVKGKTPASATTPASSVKATPQTKASTPRSSTKATASAPQSSHKTPTTPARATVAPTPTPLSSVNASARLSEACTPQQVSTANLQEAEEDRDIGAGDTVVHDIGADDTIDGGSAWDLTAADLTYDAEMTAFDAHAFKGADWDVTRIERVPRGASEDHRLQDIDEASEEDTASQPKEDSPPTAAASLLAEESPIKEPPAKEPPVEEPLAEVSFAEESSAVEPPAEEPSSKESLMEEELPAEEPPAMEPPARPSTPPRAPSVPKSVRQSPRLAARRRAQTQTQSPASKPKPKSTRVNARSPVTPQAPSQPAARTPSPSRETAEQGVVPTEPAAEEREDADAAAQKAEQPVASNRKVTLKVEQTEEDPTASSELSPERTQEANRQIKSAAPAPPTPPPAPPLPKTTSTSSSETRVESTLSAREQPAASINTETSRASLSQAKGKITQTESTPAGSKIPLATGGRSQPPVRPEASSSTRAEPAALTPVQSTPVASTSADKGASRPVQKPETPIGRTPAEVSGSGRTPTSFVKEQSRQIEQALGRRPAVPSKLSKQVIPSSSPAESPVAERTYSRPQSRASHEGPTSPSTSRRRQSDVAETSFASSSSSSRLKRRFEDHFDDDDSERYVHRASLHEELTAASDSGSEFDPEFPSMVAVSSIDPRAAARAAAILKMHHNWVENGIMPDGSRVGTPGPQERSRARSVGAQETPQTTRRRGAHETPHSRFFDSIESSRLISKEELLHEAELDLTPRYDSSTYEGNVDGRSWTRRDWKYLEKTFKYLASKADGPGVNFEAVVDAFLKQTGKEPVGEWSREVLLMRVRALARRHGQTEASEDRESKRQKTTTPANPPPSTLRKVMGWLWRGNTKPQETAEPAAATTSVAKPKKQRRDNDFLQTRDDSFEIGEVTMAATPSRPQDRRHASPPFEREEAYNAERSFEVDLERGHQSYDIPYEEEEEDEEEFFPEPTTYTARGERSSVTEASTSMYDHHHHRAPTPSSSRKIYPDLPNLNFPNRPHSLASSTRRYEESRPAGSRLPVMGTPRPRARVRSDSSIADTSIASRPGSVRDMVRGFEETQELDLSFESARREREKNELLGLRRVRSVVEKVKEKHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSN2</accession>
    <name>K1WSN2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSN2"/>
    <dbReference type="STRING" id="1220162.K1WSN2"/>
    <dbReference type="eggNOG" id="KOG0090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_750456_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSN2"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40214" checksum="A213561B5286B746" modified="2012-11-28" version="1">MSSETVTTTVTETKTWASGAAEKIVSHPKIQEALRHPLLQHPALRHPLLTDPKVVAIASGLLVILLVLCCNRKSAKKGTPNVIFVGPPASGKTVLFSKPHFSRSFYYDRGAPLSRRGDEGGHARRCSGPRAPARPGQQAASRQHRRRLCRRHYPHSQLTSRELPPLLTQMAGVFNRRLNGPTPQLLILGHKADLLSGSSDKCPADITSSARDTAAERLRSILTREMDRLKAARGGSGGRIEGMGKVQTSRGFWGRLFGAARAGEIEAEGEDDEAMVWGGPGAFRWEDVEGVDISWGVSAVGPANALIASKERGNGLNELEDFLWDLHLRQRMAARPADAIGPTTSHHMTEEATRALPPARTKPWTWEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU81</accession>
    <name>K1WU81_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU81"/>
    <dbReference type="HOGENOM" id="CLU_2086474_0_0_1"/>
    <dbReference type="InParanoid" id="K1WU81"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="117" mass="13202" checksum="D94486A797DAB220" modified="2012-11-28" version="1">MPAESASPVVSPSTFPPWLDGYSQTAGLLRKLHHERDARTAFNEKGCWACAMPVNVEDEEDQFVVQLTFSRTYDALEDRIDTRRVLEPAQASEQLFGARWEKSNQSAVVESTGKVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXK1</accession>
    <name>K1WXK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXK1"/>
    <dbReference type="STRING" id="1220162.K1WXK1"/>
    <dbReference type="eggNOG" id="ENOG502QQGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349905_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXK1"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="805" mass="89557" checksum="5356AB28EC33EC1C" modified="2012-11-28" version="1">MTITTSAPMALSPKPSSDLQQLLDQTGKSDYPGVVIGLINTAGDELFLGSSEGTTVDSVFWIASCTKLIASIAALQLVEAGKLTLDGSLADIAPELSHRPKFVNSDPNDLTTEPAKHLLTHTSGLRYAVFDLKTAHWLETAHPGGSQFAPLDMPLSSEPGEAWAYGMSMEWAGHIIERVSGMSLGAYVEKHILAPLGIKDATFQIETRDDLKARLAGLHAHSGEGFTEIPYPDPLMKPQYESGGGGMFASPRAYLAVLSAVLNGGVSPTTGARILKASTVDEMFVPQTLNVPNQGALGSGILPTAIPAFSRPIPLGSGKAWTLSHLTNLEEERGKSAGSAEWYGLANCYWTIDRQKGVAAIAFSNALPFGPTASGPTCASTVHKLKMAVAFSCEHFPDLWDMVIAHTDHGTQLALRLVCKFLRFKIDCFQSRYLVISEGGDSAQLIVTGPSRHIPYFNEQAHIHNEPGFWLNRPTVARVAHTRVLDIQGYCPPSNDPDLFTFMHFPALEVLRLTPSVADYDCDHFTPYVPEHFHARTLVLFSNPMGCRAMDKHWWFFMDDSDDEDSQALVPYDVDRSRLHRSVTKLVLNMRGLPTAFPDMYPFVSRIPSHVREVVANAPYYQSLDDRGSVHFEVSAHIEQIHLLAVVFRTMSTRFTCVGFDRLASDFADKFMRELESRYRHIFFNTVDYTIEDELTLKLPDETRAEYIECSTSGVRRGKQLPRNPDRPLISLKEQVDQLVSRVEFITKVEYVERVGRETAELDLLEHPDPDDRACVGRKYNWRRREDYGDTGMADYWHQMRASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXK9</accession>
    <name>K1WXK9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXK9"/>
    <dbReference type="STRING" id="1220162.K1WXK9"/>
    <dbReference type="HOGENOM" id="CLU_726013_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXK9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="381" mass="43437" checksum="056799507FD44A20" modified="2012-11-28" version="1">MLTLLKHDRIVETLFQHCGIKAQLQLRRINRALCRKINNLLFHHLVLTAMPLRGHECDVKVEGRFPLPLRMRRLNPSAWKLAPRKLVQHNLFRYTRCVTFKGGFPHGCHPTFLRSAFMSVDTLRIIPVDGLYLPFVPFGASTVVVWIPEHEQGFEYLLDHPLGEQVPCDMSFYPPLRTTKVVVHAEGTNIHLLEAYPFLAYLPPTTDLVVVAEDLSLRRLAGYRQVGTSSALFGNLSIMLRIIPDLELMVVGLWGLRQISSGSLAGYATDHPTVTRAAISVLNGVYDGMVIFPQEAVDMAALFLTRPWFRFKTSKQYRDSVGVERERLECVRDLNDPKVIKEREERLYGSGFPRHEVYEPAMERPALDLFEYLAETPGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY59</accession>
    <name>K1WY59_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WY59"/>
    <dbReference type="eggNOG" id="ENOG502SFZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254428_0_0_1"/>
    <dbReference type="InParanoid" id="K1WY59"/>
    <dbReference type="OMA" id="AYYYEKP"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37458">
        <property type="entry name" value="THISBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37458:SF1">
        <property type="entry name" value="THISBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1399" mass="142694" checksum="F1614D39216CEBF9" modified="2012-11-28" version="1">MQAQLQLRDGSSLVGTTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPSTQVVPFTLGISVGISVVTPTGLIPSLSCSWACMQHTGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY68</accession>
    <name>K1WY68_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WY68"/>
    <dbReference type="STRING" id="1220162.K1WY68"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_1"/>
    <dbReference type="InParanoid" id="K1WY68"/>
    <dbReference type="OMA" id="CVVIMSN"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="Alpha-amy_C_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="527" mass="59069" checksum="B4058BA49BDE4D35" modified="2012-11-28" version="1">MMQYFEWYAPGNGVHWKKYKEDAAHLAEMGITACWVPPPTKGSSPEGTGYDIYDLWDLGEFDQKGAKPTHWGSKQDLLDAIEEAKKHKIITYIDAVLNHKAGADEKELFKATMVDRNDRTKTVSDPYDIEGWTKFTFPGRSGEGKENGEANGHANGDANGDANGDANGDANGDAKPKDKADKAYSQMEWNFNHFTGIDYDAKTDTKAIFKIKGDGKDWADDVDTENANYDYLMFSDIDHEHPEVRDDLFKWGEWVLNETGAYGFRFDAVKHISREFIGDFVKHVKEKVGNDNLFCVGEFWKDSVPALNAYLDGLGTQFSVFDTPLQGNFKEASEAGNSYDLRKIFDDTLVQSRPIDAVTLVDNHDTQVGQSLQNWVAPWFKPIAYSLILLRGEGYPCVFYGDLYGCGGDNPQQAVNQLEDLVRARKEFAYGDQVDYWDHANCVAWLRKGDDDHDGLVCVACNGSEAGTKRVEVGKEHAGEKWSDVLGWTQGEVTIGDDGWAEFSCPAQSVAVWTKTDARGREYFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1UZY1</accession>
    <name>K1UZY1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase chain 6</fullName>
            <ecNumber evidence="1">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="2"/>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1UZY1"/>
    <dbReference type="STRING" id="1220162.K1UZY1"/>
    <dbReference type="eggNOG" id="ENOG502S14H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_1_0_1"/>
    <dbReference type="OMA" id="DQINSIG"/>
    <dbReference type="OrthoDB" id="10050457at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="entry name" value="NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269:SF17">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="202" mass="22044" checksum="CE81E9A51F39687A" modified="2012-11-28" version="1">MNTFILDLLSFGAVFSGILVITSKNPVISVLFLISVFVNAAGYLLVLGIGFIGISYLIVYVGAIAILFLFVVMMLNISLVEIISVGQEYTKNLPLGLIVGALFIFEILSLVPASYKEVGELPLGFVNYLNRLLLGVEGPSMNRVHMRFTQPGADQTFTNYLQIETIGEGLYTYGALWLFLASIILLLAMLGPIVLCLQPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1M1</accession>
    <name>K1V1M1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delayed-type hypersensitivity antigen-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1M1"/>
    <dbReference type="STRING" id="1220162.K1V1M1"/>
    <dbReference type="eggNOG" id="ENOG502SWH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055507_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1M1"/>
    <dbReference type="OrthoDB" id="2560920at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="339"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="412" mass="42715" checksum="59CA529541D76C9C" modified="2012-11-28" version="1">MCTRGKHCSSTLAAGAGPTHAETWAGPTGEHSPGKGHLVAPGSAHSAPPYERTALRLSSFKSKQAPLPQRLSSQYTLYGNLPQPNLNTATMRFSLATIALLASAAPAVNAAVFMQCADPRIQPNLLSVVLASPLPPPRIDLTTSGVVNAVTTTLSPAAEFNGCRQYCLEKNMVFSIYQPGLAGLLASCFCAALEPEAEYVTKAKDPAGNCLPGSYAVSYLPSAPWSFTSCATGSTVSGGPPPFESYQNSKCFKDCAAYKHMSMVSTEDGSYMCTCGNTLVAGTPATCDRGVAQLYTTGATASGVARRNKIAREAARRNAKRTLCPDFQTACIIPGTDSFECLDTGMELTSCGGCSDGVFDPPLDAEFTAGVDCTALPGVAAGAVSCESGQCVIWDCASDYALVDGTCVALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V375</accession>
    <name>K1V375_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V375"/>
    <dbReference type="STRING" id="1220162.K1V375"/>
    <dbReference type="eggNOG" id="KOG2786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1215536_0_0_1"/>
    <dbReference type="InParanoid" id="K1V375"/>
    <dbReference type="OrthoDB" id="2017946at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="228" mass="23699" checksum="368EE8E85F3DE2C2" modified="2012-11-28" version="1">MTTSPARALPTLARRAFSTTAAVAKGSGGKPTPNKDHHIVQYNDDDFPRGFGVAATHCGIKKNGALDLGVLVSVSERPTAAAACTTRNAFKAAPVTVTTELLASTDGRARGFVVNSGCANAVTGSQGLDNAWAMSKSLTNALAPQPETWGKEKAGSLVMSTGVIGQQLPIEKITSAVPKLAGNLGLDSKSWMDLARAFMTTDTFPKLDVSLRAAPISTRQSVDQAVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1V466</accession>
    <name>K1V466_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V466"/>
    <dbReference type="STRING" id="1220162.K1V466"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_1_1"/>
    <dbReference type="InParanoid" id="K1V466"/>
    <dbReference type="OMA" id="WQGNYYP"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="249"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="414" mass="46390" checksum="BC9EA821D92F32D8" modified="2012-11-28" version="1">MVKEQNGKSNPDNLKYNSCDPQALHRVHLWYRVHRPAPQEPALRVVSSFHAHSPDIEPTPQQLRWDPLTFPGAEGVDFVDGITTLGGAGDTQMKDGLGIHFYAFGRNMGKKSFYNSDGDFLFVPVQGELLITTEFGKLHVPPLHIAVVQRGLKFTVDQVNTTGVARGFICEIYKGHFELPELGPIGSNGLANAKDFETPCAQYDDSAEEEDWTIVNKFLGKFFKYEQKHSPYDVVAFSGTYVPYRYDLKKFNAMGTVTYDHPDPSIYTVLTCPSDTPGTAVADFVVFAPRWLVAENTFRPPWFHRNVMSEFMGNICGEYDAKAEGFLPGGASLHNMNTAHGPDTETFKKASIAELKPHKVGEGSMAFMFESAYQVATTKWAIVESGKLQQDYWKAWQGLDRISDLPHDAQQQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8B9</accession>
    <name>K1V8B9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8B9"/>
    <dbReference type="FunCoup" id="K1V8B9">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8B9"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="InParanoid" id="K1V8B9"/>
    <dbReference type="OMA" id="MFKDMTI"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000034">
        <property type="entry name" value="Related to Cullin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="414"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="776" mass="87176" checksum="249E08D920F0C69B" modified="2012-11-28" version="1">MSMASARRGKPKIRAPPKLGPDTSIKDTWTKLSHAIREIQNHNASKLSFEEHYRYAYNMVLYKHGDQLYTGVKKLVAEHLDQLAEERIVPAFPRAGGSHVAGALGGGAQAVEQAVEGDRFLRSVKSVWDDHTGSMRKLKDILKYMVYTQSAKVPTIYDVGLELFWSHIVRSNLYPIHTHLMGTLLSQVQLERDGQSIQRSTVRDCVDILLRLDNPMTPGHTVYVTDFEPEFLRRSSEFYRLESIAQLDTGDAPSYLRNALLVDNLLTPHLHSIMGMPGTGLSPMLDGDRNGDLRRMYNLFLRVPDDKGKSALRLALRENIEARGKAINEGAAAAVAGPAAAEGEDEPVDRKGKGKAKPPSAMAGALAQALRWVQDVLDLKDKFDAILDNAFSGDKQVQASINEAFQSFINANARAPEFLSLYIDDHLKKGAKSKSEEEIEAALEKTIILFRFLADKDKFERYYKNHLARRLLYQRSASDDAERGMVAKLKVEMGFQFTQKLEGMFNDMRMSVESASAFRNYLGRHGGAPPFDFNVSVLTASYWPQPIVTTSSCCFPPVLAGAQATYQKYYDSRHSGRRLAWQASLGTADVRVRFAQRTHDLNVSTQALVVLLLFEDLPDEDVLSYSELKTASDLSDGELQRTLQSLACGKHRVLTKHPKGRDINPDDTFSFNSAFTSPLARIKIMQVASRVESPKEREETQEMVDEERRHMVEACIVRIMKDRKTMGHNDLLSEVASQLAKRFQPSMATIKKRIEGLIDREYLERTGDIGVYHYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8T3</accession>
    <name>K1V8T3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8T3"/>
    <dbReference type="STRING" id="1220162.K1V8T3"/>
    <dbReference type="eggNOG" id="ENOG502QYQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016105_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8T3"/>
    <dbReference type="OMA" id="WFIGKVP"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="255"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="412"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="507"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="633" mass="68220" checksum="EFA4F91E4837E5C6" modified="2012-11-28" version="1">MTAVSPKPSSPGSPIVEWDESAVNEYFLGLGLDGYKDVIYEHGITGDVLCALDNETLVDLGMTSLGHRLNVLRNVYEIKKEQGVEMGEDDWRPQEEVALEAMEHAATIDRMWGLVLDQQERMMQLERDHARLIRALADNGIALPGVAPQLVEDAATPTTATTYAFDSPSQLLPTSGRLTASSGGLTPKPPQLARLGSGSLRAGNGKRAEGSSNRSGSAPLPSSPTPPVDLPPPTPAPTNASHSDKSRATAAAHSAAKSFRVTMEDPCWKVLPAALKKYKINDDWKQYALFICFGNTERCLSYDEKPLLLFQKLKEGGQRPVFMLRHIRDIKSPIAVAQQKQALKLGLPPTTSQNLLPTVDTVPSPTEQTDSRPGGRTPGEGGFPDLPSPRDKAEKGAGPEPGTILDVDGKIHKVTYATSIYPYIADRADEFDVAVGATFVVMSKAKGWWFVQKDPEGAGNIVSDPSKSAWVPAGCLLELEKAIAQVSPRSPGKLPGRAPLLPSNIMSSSYPGNVLMDYTAKNENELTLREGERIRVYKKYCHWSYSIKEETGERGWVPAWFVGKIVTENGERERSHHRTNGTAVSPALPSAMTIPGASSAAGGGSLENSSQQTHTTGATSTTLVDNEGQGNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1V939</accession>
    <name>K1V939_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="1"/>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V939"/>
    <dbReference type="HOGENOM" id="CLU_3351394_0_0_1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="37" mass="4125" checksum="1C48AA222F088811" modified="2012-11-28" version="1">MGTITFQLSAPSSLSTTLFQLQNNQSVEITLPDLQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V976</accession>
    <name>K1V976_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V976"/>
    <dbReference type="STRING" id="1220162.K1V976"/>
    <dbReference type="HOGENOM" id="CLU_049054_0_0_1"/>
    <dbReference type="InParanoid" id="K1V976"/>
    <dbReference type="OMA" id="DESAKTW"/>
    <dbReference type="OrthoDB" id="2576290at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="3">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36565" checksum="734E2C95660DE6A9" modified="2012-11-28" version="1">MWKQKHSDSHNLHGVQQTYSATEFLKVMDYLRTVFLQDSVFLMEAWPHLGVWSDPLFHTTCWQTWATRLKAATEHSIAERASFRSIDHVVPQLAEALHQVQQDVQSSHAKLESSVLHKLDKLLEPVERKVEHVNDRLDKVDTVYDMLRSGFVLRPAQVAGPSEELQLAAQSESQEVTTSLTPANSHPSVSVGTAMTATVVQPPKRKQRDPPPHEYPYRSMDRSVTTVPQLWREWTEGTATRLPVQEMDERYGRKWLEDESAKTWHKRRRVIITYVSDNPVFAADGPWAAVKAVEDERGHMTLDKFSKELSKRARARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAC9</accession>
    <name>K1VAC9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAC9"/>
    <dbReference type="STRING" id="1220162.K1VAC9"/>
    <dbReference type="HOGENOM" id="CLU_641215_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAC9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="428" mass="45557" checksum="03E63A7D5DB493BD" modified="2012-11-28" version="1">MYRFCRGDKQGYNVGRPCRPRPREPAFQHHAYCVICASALPRPPYDFKLCAGSSEEDAEYVDNVEIERAVRRLPFLKSSSGDGKRSIWGVIGGSKGKSGQSGAGAQDRNNGGQEGQGLKGGQGAQGGGKVFERGVRGNNGAQGVPAGVGQAQGAQVGEDKREWATRVNAAFAARRAQPQSQPEGQPDLRRKHSGSFTLYGLSRSNSRGDGGDIGRKSGVNGGKTGKGGSGGRPGSDEPEVWVVSRPKVVQPRGPARCRSHAHTPSGLARCITPEPEREMVTVSLGLGLGRLGPFAISKGGITEKEQKAARRNSRWSLRRSSVSSLKSMRSTASMQSRASERSTASTTSTASIATTMNGDMNPPTTTTTVSTGAANANTQKGKTKKKNDKVPGTVSAWPSWTVLSALRMFRPQHPETKSTRVAREHIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAH7</accession>
    <name>K1VAH7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAH7"/>
    <dbReference type="STRING" id="1220162.K1VAH7"/>
    <dbReference type="HOGENOM" id="CLU_093209_2_0_1"/>
    <dbReference type="InParanoid" id="K1VAH7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="1">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="153" mass="17261" checksum="09F35F8C065ED37F" modified="2012-11-28" version="1">MALPPAASRPWGTPATVFDRLAGTWQLYRTIEGQAEMRGTASFTALESGMLKYREEGRLRLADGNEFSAHKEYVFERAASGFNVYFAETPLRLFHGITLASDGRSLRGSANHWCQPDTYESQYVFREDGTFTVEHKVRGPHKDYVSVTSYSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCU4</accession>
    <name>K1VCU4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein HMG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCU4"/>
    <dbReference type="STRING" id="1220162.K1VCU4"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320543_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCU4"/>
    <dbReference type="OMA" id="YNAPDAN"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="444"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="561"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="444"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="561"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="739"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="317"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="779" mass="82474" checksum="8BE10645E600C0F2" modified="2012-11-28" version="1">MQNSSTATAAHPGHLAQPWSNPHMYSNTGSHQRDPTNPRSYATGAGGATSDDQYAAYQQAAGFANVGTGYNYGGNMSNLYNTTSPSMPSGSRRTSNPKSPYQQTSSVLSGGHSSQGVGSGQSQQYGSGGYYGSYYDQQHSGHHQGSAGSQWQQHYSQPSSGFAQAPVQGRQSSSGSMTAGAAATSGSGGNNDQSQQSSRTGAGSAFDYSAAGQQGYPNWDQSRQGSNQWQQQQQPSQQTSGSGSGAGQSARTQGSNSSNQQQSVVSPWQGYGNHHPFPPPPQPVPQMGGQLPPGQYGAWNQWNGAPGYYPPGPHQGQQQQQQQQQQQQQQPTQQQQQQAPAATQANANAAPAASVAAPAAAAAPAPAAPTKKSKKKDAAAAAAAAAPPATAEPTEQVLGKRPSESSADEGEGKAEPKPKSSKKNKKEEEKPAPKAPTKSHLRPPRQAPSAWQLFFTDELNKAKAAAAAEAGTTPGGTPIHPKLNVAQIAKDAGIAYANLTDERRRYYAGKVAEGKEQYKKDLAAWQATLTPEDIKTENAFRTQQRKEGKSRKGNIKDPNAPKKPLSAYFLFLKGIRENDDLKRQVWGAESETTRQSVLAAERWRGLSDDEKRPYLQQAEKDKQEYEHLRKIYEEDAALRAKGEAPTDRPQFAEIQSAVVEPPKSLLDAPSKKSDGPKGDKADGRNAAPSAADPAAAVGTINPANTTFTVAHAGTPDPEPTAPGFDAPLEIEDFHGFDDMDLTGIEGMTGHGASNEGQWDDLAYVGGDDDKNKGIPGKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDC5</accession>
    <name>K1VDC5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carboxypeptidase s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDC5"/>
    <dbReference type="FunCoup" id="K1VDC5">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VDC5"/>
    <dbReference type="MEROPS" id="M20.002"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="InParanoid" id="K1VDC5"/>
    <dbReference type="OMA" id="DWTHHPF"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="339"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD01985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="621" mass="68956" checksum="0389BD892E06EC85" modified="2012-11-28" version="1">MSSLPLFKASDQDDAMSEKQQQPQEAHGHDETLRQPYALGVRPGQPSQRERRSRWVLVGFVVLAILAGIHLSSPHGLTGCLHAPFRSHSSHHGHHGHHGHHHGHGHALKAKNIGGKSPSCPAQPDPIEPETKVDWTEERKKHSAELHAQAVQHATQSYDDNGEPGEDPRWEPFHDFLDWWRDAFPTAVERANIEMINTLGILATFEGSEPDLKPLVLMSHYDVTPAPENTWDRWTYPPFSGHNDGTYIWGRGAADDKSLFVAEWEAVTYLLEPGWTPRRTLILSHGFDEEEVHARRGQGHIAPFLEERYGKDSLLMVVDEGSGLQDDFFGAPFALPAMGEKGYLDVRISVGTDGGHSSMPPKHTGIGILSEIVVALEKQPFPVKLTERSPFLTTLACGAAYAPKFPKEWKKLLKQGPKGWEKLGKGLAAKDKMHAALLHTTQAVDVFHGGAKVNSLPELSEVEINYRIDFDESVESTQKHIEKIAHKIAKEHDLKLDAWPQNATTASGKVTLSMIGKALEPAPNTPAHGGIWDTFAGTVRAVFQPPKGKELIVAPFATTGNTDCKMYYNLTKNVYRFMGLRMDDIYGIHTIDEHSSIKGHRDIVDFMHALIQNADAYDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE36</accession>
    <name>K1VE36_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_03402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE36"/>
    <dbReference type="STRING" id="1220162.K1VE36"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033744_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE36"/>
    <dbReference type="OMA" id="RNWMIFF"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="595" mass="65139" checksum="FB8FBA2A2225F58C" modified="2012-11-28" version="1">MSEQPPTTPGGSGASAPGSAPSPAPSASTAAPASSSTTTGTTTAAGAAAEAAKKAPQELKGFRKALEHTGLPKSVINWKPRLPSRNWCIFLTVVGTVSYIYYDDRKQAKEIRKRYEDAVRPMAAVPLKNTLDLPRKVTVYAARWPEDDESDRGLLYFRKYVKPYLAAAAIDYELVHAPLYGSVARIVRAKVLKARRESLNLNPGDILGPVEKTDKERELERQADEGGVVLMGRPTMKEYMAGLTAGWSNGVSEWVWEDSVKSTLGDEPFADPPAPPAGEVVLESSPEGTAVAATPVPAVPTGAGVQHVGLPNPAAKLSLPPVEDDEPVKKSWWSGLFGHGGRKAPSPSPQTQTQTPEAPQKFSIPPNWHEPPTPLPPHAPVLLVDWCNHLGFKQIPYMIYDFFTEHKRVKAGAEAAYALITEQVRAFEPPSVTAEVAVVEDAEALHEGEAIPSAASIAGHQGGDLDFDTQFEKYYKKDYAKTPEEIGKEREKYYDEKLPKRVEAAKAFARGEREITPEEQKSDKPVETVQMLRDERNKKELRWEGNLEGWSIVKPDTPVAWDPRFAGWLKVYQAAPESLDAVMNVPEKNGESRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE93</accession>
    <name>K1VE93_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE93"/>
    <dbReference type="STRING" id="1220162.K1VE93"/>
    <dbReference type="eggNOG" id="ENOG502T6DY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639665_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE93"/>
    <dbReference type="OrthoDB" id="10642884at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="429" mass="46349" checksum="5E1237FEE5477852" modified="2012-11-28" version="1">MPPERELPRKRGQRGKKKRGNTSSAATPSSATPSSVTRSLATRSSATPSSATSSALASATSSALSSATPSSATPSSATPSSATSSALSSATPSSATPSSATPSSATSSALSSAITTGRGRKNLDFKEYTWERFDDSNTTNNYRVMPTRESLALTLPASWYDVPATGNVLHGYNYNTPLFAFFTLRQGIKPHQLDQLTTACQAIEATGLKPQTTAAHGGDFHQMWFGLWRRYSGFVFITKHAREQKLGAARAVEHLCALYDTIMGGRALNMLQEVDPLTRDRMAQHHRQVTSEFVRGMAEPAAAAANQTKKSVEVLESGQGNFDTNLRNRLGGMGTVLTVSRGEGTDFHFDHNDFKAHYTVVFVIGRRAILYFKALNRSVILCPGEVIYFQSWLFEHKLIWDPSDESTAYSAVFTAFTCKNAAMSAGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEJ6</accession>
    <name>K1VEJ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEJ6"/>
    <dbReference type="FunCoup" id="K1VEJ6">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEJ6"/>
    <dbReference type="eggNOG" id="KOG2560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019317_2_0_1"/>
    <dbReference type="InParanoid" id="K1VEJ6"/>
    <dbReference type="OMA" id="KYAWESQ"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="133"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="547" mass="62587" checksum="1C6C8448F26A77E1" modified="2012-11-28" version="1">MIRLPADHSEKIAGSSYRAQKALEDAKNGGDKPAINPHVPDYIAKAPWWAEINGEPSLNHHRKEEKKKTPIDQWYDRGVTGPAATKYRKGACENCGAMTHKRRDCVERPRKRGAKFTNKNIAPDENIQEVSREYDAKRDRWNGYDPSSYKSVVEDYEAAEEARKKFREAELEEEAKRAAEVKREAKKQKAKDEDDEFGTDDDSDEETGDTSMQADQVDQTFDTKNRMTVRNLRIREDTAKYLLNLNPESAYYDPKTRSMRDAPEEGKSAEDLRFAGDNFARYSGDATNMQKLQAFAWQSAQRGHNVNVHSNPTAGELLHREFQQKRDVVKTQAKTSILEKYGGEEHLERLPQELLGGQTEHYVEYSRTGEVIRGQEQAKAKSKYPEDVFPNNHTSVWGSWYDRESGQWGFACCHSLIARSYCTGEAGKEANQASTAAALLGTNDDEEAEEEQPVKTLAEIHRERMEAGKGKKKDDDKSREASDEPDLDKERLKRAVAEERRRKRMGEDEAWEATKKAKTDVTEEEMEAYRMSRNAFEDPMANYEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG13</accession>
    <name>K1VG13_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000365">
        <property type="protein sequence ID" value="EKC99720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG13"/>
    <dbReference type="FunCoup" id="K1VG13">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG13"/>
    <dbReference type="eggNOG" id="KOG0360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="InParanoid" id="K1VG13"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="559" mass="60178" checksum="6DDADF7FBCF0F87C" modified="2012-11-28" version="1">MAASMYQRDPRAGLFLGGSRVSGSEVRDQNVTACQTVGNILKSSLGPVGLDKMLVDNVGDVTITNDGATILSLLEVQHPAARTLVELAAQQDKEVGDGTTSVVLLAAELLRRANDLVRNKIHPTTVIAGYRLACKEACRFMVDHLSTKVDKLGREALINVAKTSMSSKILSADDDFFAPLAVDAMLAVKTVNPKGQKKYPVKAVNVLKAHGKSARESFMVNGYALNCTVASQAMKTRIQNAKIACLDMNLAKQRMHLGVHITIDDPDQLEAIRARESEITLERVRKILASGANVILTTKGIDDLVLKEFVEAGAMAVRRCRKEDLRRIAKATGATLVSSLANLDGEETFEASSLGQADEVVQERISDDELILVRGTKVVNSSSIILRGANDYMLDEMERALHDVLSVIKRTLESGSVVPGGGAVETACSIYLENFATTLGSREQLAIAEFAAALLNIPKTLALNAAKDSTDLVAKLRAYHNAAQSAPAGDPKQGLIFYGLDLLNGEVIDNRNAGVLEPTMSKIKSFKAALEACIALLRIDDSITVAPEQREQEDPHAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGH1</accession>
    <name>K1VGH1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Malate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000397">
        <property type="protein sequence ID" value="EKC98131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGH1"/>
    <dbReference type="FunCoup" id="K1VGH1">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGH1"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_6_1_1"/>
    <dbReference type="InParanoid" id="K1VGH1"/>
    <dbReference type="OMA" id="AWHAVIM"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="512" mass="56089" checksum="F15FFE0D55AC42E6" modified="2012-11-28" version="1">MSTLSRPLSTSTATTTTTTTAHTGTSHGSPKESRRNMTPSPEHNDGDTNGLPAPAQAAVAARATLNRKLSYRALHTSPSFFSINMGTGIASILLYNFPYHARWLRILGDIVFVLNVVIFVVLLFLTAYRYLKFKNSFRITLEHVTASMFWGCFPMGFVTIVSETDKQNMVAFSCVPAWGRNWARLALGLWWIDVAVAILVNLGMVFVMFVLQTHAAAVIAPTLLLPIVSTVVAAASGAVVSTAMLPYDPALARSTLYTAFVVWGTGVPLAMMMITIIMYKTITVGPPKLGAVMASFLPLGPCGQGSYGIASLGQTARKLVWEYNTPLLPKLSMDANRSISDGIYGGCLVASLILWGLALCFYVLAFAQALYALRKNWAWLGANKFHVGLWGITFPIGVWATATITLADELSSPAFKVIGAFLAAQVIMHWLYVMVLTTWTGFDGRFFRAPEIQESPDGVVERILWQAKKDRAEHGLTRHISRQDIEAGHTFSETAHRVASREPKDHLENPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGR6</accession>
    <name>K1VGR6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGR6"/>
    <dbReference type="HOGENOM" id="CLU_335611_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGR6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="850" mass="95942" checksum="4BB04090D4B85E39" modified="2012-11-28" version="1">MAIATLLEEENGAEPIPDTADHRLLGDGTTSGSRASASTPSKIDDQETPVSPSLLALTGKLAHGSGFPHSPWHYVSDVDPCSKKHYVSDLLEFCDAPPSRLSPQVIADLDALHSRTLHLKARNGVWAAGQSIEVTCRCQPRKTMIKRDVPNIPRDVSGHLYPESNAEGYWPFDYDPQSEANRNNILQWVLKRLAEYIWHHTAPYPYATFPSAKSIGWARLFPARLLPDKHVFGMSVPILHLQRPISFHGGPMVRLLKYTKPDRMEMTDLRYRWLSYLYRGPIPDGRCHDFPPLTCSIITMFLGPQLDATAAQHLWGVYKKCDIEVSRREGWIEAGYTPPCSLRDRKPCLLQGINGITVAFCAAPPSRINLFIFPEVMDVILSDLLRNGAIWLLCNKRESLKDLLELCLGRVYFTATNSDTCSLNAALPSVCRRVSLIFKAWLHRPIAPYSLLSTPLSFQEILQDIGALGDRNIEVPTSTRIQVFAGSMVLNAWREQRTETMERQWRTYHVAAFGILRGCAVGTVANIMMERIEARQEASRRMEFRLKLVADVIKTVMGPLTGLSGFAVTPELDTTVQMLTESLNRRLAKANRQDFAELKTMLQVTRDTLLQQLDSYSGTIDRDFMYRHFCQALTLTVAGSGTEEAGTREHVPAMFDPSNTSLTWEPLVSNRDTRFEPEIAHMLFHDLSRTRIVHRSHAQWHDLLMRGVNREARQRLLSQYGQFRWVFTEKRAYELAALFETHNRQCQKAMVASEKRSPPMIEAASGPSSESPSTKSRDDLGGHTENDDLHSWPKLAQVTDDYTAGPELHLKARTQIYVELGKSRGSYRFTSVEDDNIKGAILKSCVKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGX1</accession>
    <name>K1VGX1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGX1"/>
    <dbReference type="FunCoup" id="K1VGX1">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGX1"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018406_4_1_1"/>
    <dbReference type="InParanoid" id="K1VGX1"/>
    <dbReference type="OMA" id="LIHRECK"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="57"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="62853" checksum="D2E6BB0CDD7818EB" modified="2012-11-28" version="1">MPADLSQFKLPSRSDVPEEMRAQFEAFFKSKMGDLLSEMNAETSPDDALFRDELAGSPLEVKTSPQRGRGLYAARDIKAGELVWRAPKLTPGETLLKTKPLVSVLSKPNLYEPAAGQKMELHCNHCYLLKPAQRCSGCKGVYYCGAACQQDDWPSHKTECKALTRVRQLWVQSYPEKAKEGLNNSWIQAEGARALGLLTWARKAYRDQHGRDPDYWPKVEKMYAEGPDMGTGVHGIPAADQMAIHLSYYVGAAEPPKDPNNLELIDMEPYGFQDEQLMSFVRSFVLNAFTLSSFDLKPIGVAMSPLLALFNHSCAPNAAIVFPRGGKEMVAVANADIAAGEEVLTTYVDISDDKETRQGDLQSRYGFECECPACTLDAVDPRNCLLHECGGLARMPETVKCDTCGASWTVSPNALRDLVNEGLSLVEADDQDQLDPDDLPRVAEVIARLEKIMPPSSRPLLRLHTIAKNLHVPAAQPEALAYAHKALAGAYKVYPRNHPSVALLRAESANLAAQIAVHIAENGPGISEDEIKRCIADLRTAADHCDLAFGKESTIATSLRGFAHDMDVSLQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH01</accession>
    <name>K1VH01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH01"/>
    <dbReference type="STRING" id="1220162.K1VH01"/>
    <dbReference type="eggNOG" id="ENOG502QRW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_0_1"/>
    <dbReference type="InParanoid" id="K1VH01"/>
    <dbReference type="OMA" id="FRWEDSV"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="345"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="558" mass="63220" checksum="A367414A700A138D" modified="2012-11-28" version="1">MAANLPLTHLYFQQQMNPNRCKKEYEHCSSFTPIPVGIDARCKADNGAGPISPLLYSGFLEHLGRCIYGGIVDDKKHPSPAELLEEQGNGRAGWRKDVQKVLAADGDLAVPMMRWPGGNYVSNYHWQDGIGPVDQRPKRVELAWRTAEDNRFGTDEFMDMCRANKWEPFICLNMGTGTLEEALAWVEYCNSTGDTYWANLRRKHTGRDEPHNVKYWGLGNEMWGPWQVGNIDAKEYAAKAKQWAHAIKLVDPSVILISSGETGFSLWDKEVLSEVIPYVDMHSLHFYSSLFHEYFTAPGHNFEKNVFSPAAAEAGIKIAKSLIDLTNADNSFRGVAAKDVKICYDEWNVWDQTKAGVDIGLEQVYDFTDLLGTVAWLNLLVRQSADVAVACIAQSCNVISPILTRPDGVLKQCTFYALQLFSTMMRDGHLLQTPDMPDFYDGPTWPYFVQQIKCNPRYIDIVAMGKDDGDKRSVRVSVLNRHPELDWDANVINVGGLEIEKVTVHEMYNDDLSAANSWEEPEKVVPTIKEYSAQEWKDRKHTVRKHSWQFIVVDGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH16</accession>
    <name>K1VH16_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000251">
        <property type="protein sequence ID" value="EKD03415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252714_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH16"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1427" mass="153071" checksum="4A9EAA6C5D1CF7F0" modified="2012-11-28" version="1">MNPAASAEAASDQTASAGQTSSQDRSDAVPDFSFYRLTEQAPAWNPHGFCGEDFTRASNLAHQPGCTANGQHQIFTEPQVTPDPAHPRTPFTPGLSPLHLAGESLPTSFADLFDVAKKALAAVLSSDVEPSTEEKTAYNEWAASMQSRSRDRSPTSPPCWDLLPGMPPVVPLAPGTNKYVPSSLLALELVFRLSFTQTVPEGWGMLPQDIFKSPAGPVSASVFSANCNRFAFSQAERTVLHRLDRHFVIHAQAHLCRTGGVFLPSLGDPQYQALVKSSVSSRGDLYSNSFIWADRTPGPRAPAVPLKLSAEEAAALARPLPSESHHQPILLDSEAGPIHWGQLFSAVLADQDHLFSRPAGSEHSVQSWLHEWHRAAFSLKQDSTGTLPSVVPIVPTIAAARVPSLAPTLAVFPGRLFALDAALTLYYFEVLPSGAKVKVLKPLSSSLPRFAECLLKAGFAHAEVLAAIGPAGRGLASTFFSEAELSFDFRFGSFFPHGRALLSGKALDETRLKMFGPPVVSLSVSPGPEGVFKVPSSFESPMTRALAAPITFMGVDPMLQAVPAPLMGDYFAFQSSLGFDARRNAAEGEDPHTPPYNLSFRNRGEIVFSPQHASFLKLTPPRPRPSELPTPNAKRPSRGHGSKGDGGGGGGGDGGGGGSKGAPPPPLTPPDSARRPHFNSSSSAQQSPTTPTRQPRNRPGPAEESGHPELDSCDLPQLDEAATSRAGSPSPQENQDSPTAPKGNKGNKKVTLKVVARVVKGEAEDTSEPNPFQADGPQVPPPLFRSLLGSRSPSPPSDNDSFGSSRSQHLARDYTPGVDVAITSDEPLVPESQEVEEMVVDSEAACEPMDGIETSDPEVHVETTASANDDDHSGDDPMVGRALDSPRVSAPPSPAPHDSQETPQVPIEVEPVHQPATQPSDEEDPTWLENIFMESPNGARFKLLAGFECDCCLDKVRDVPPPQEGPIPEGEVSPASPTVCHFQVSDDGALSSCKPQLQVAKTSPQAVTDCRRCSFLHPYPPELTQLADSIIHRLRSGSGPFSATLIKDLKFLILAIAHPNCERHWSDLAGGHTPDDFNLVTEPDPDAHRWLRPSSLPEVLGLRIDSNHSQSSTTASSRSSLRYRPGSSQSVDRHLTMCVLDLEAPPSNLLDKHKTVKTPTDLGFAFGGQPVRGPLLTHEGPPSHTRPSAEMKLAHVRSGCVLFSGPVRCRCCRQRGAFCAHVVSNLFGTPEQRKSTRTGRPFTASLPCATCPTGASYSTCEHASGSSASARRLQFLTRLAAQVLVVAAYQTCPSADFRANLVDWVVLLRDFSSGHLAAHFRRSPNGHFLGLPPPPPGSPPLLQREVSLWPLAPWRSREYKFPSLEFFGPSITATLHESTMGLVLNENGQGPSRDTVARTLPSGQCPSHLRYPTDFVELFSSSELPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH87</accession>
    <name>K1VH87_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH87"/>
    <dbReference type="STRING" id="1220162.K1VH87"/>
    <dbReference type="eggNOG" id="ENOG502TGN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414568_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH87"/>
    <dbReference type="OMA" id="ANDISYR"/>
    <dbReference type="OrthoDB" id="2569636at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="664" mass="73217" checksum="F74DB47657C1CC3D" modified="2012-11-28" version="1">MDNSAAGSKKVPIPRPRKACTICRGLKTRCLPDGEDSNPTSRCSRCARLDLVCDYSRARKGRGSAARRDNNNPGTADAGHDGRYRQTDKWNDPRMGSSVDSRELAPVHGLMNGVGMVGAVSPVGMGITSLPPMGHMNAHMQLVRGWNTQQPNMTSRAPMGSKPVAPILPRPAIPNSDHPSTVTNGHHPHAMYARSTNSAESPNNRSRAATSVTTLSNFLDPVLGFDDNRPSTDGSSHRSQAYYNTPADAGIVTEQEARYLYDQFIQHMSTSLGLFDHRFHTYERLLGLPVLLTAILSASSRYFRADVFSHISQLAEQNLSQAIATGDHDLQLVQAIIVMIVWLKGSDPTAYVKLGIMSRVLNELRVTFPVQPSAPFNNEDDERRAIDVDRTIFSLDLAYSRLLHLPASSTSSLPTSQQAEFWAEMHSHLDVPSDSHKAFLAGIWEFSSQFGSSPQKMTQWEWTESEKSLIEHLNKWINHPSMSGTMFAAFTQIIGKTTLLNLRILGLQQRVATAISPIHLMTIADEIGLAIQELAGRPEVMYFSELHCVMFTLPGLLLYNVLTEISRVLDFCRDVWQALEGIGGGTPELPITKARHCYRRLHGALDLLLRSATTPKTASSSHSVLPGSAMSGTVPEVVGQQQQQQPSTWGVDWLWQGIPPFQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHH0</accession>
    <name>K1VHH0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHH0"/>
    <dbReference type="STRING" id="1220162.K1VHH0"/>
    <dbReference type="eggNOG" id="ENOG502QURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320337_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHH0"/>
    <dbReference type="OMA" id="WISMDIA"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853792" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="906" mass="95998" checksum="63BDB873013B80C6" modified="2012-11-28" version="1">MRWPVAYLCLLGWATLAAAKPNLVTPPQSQLPPVARVGEDFVWDILPGSFTSSTPIQYSVDGLPSWLNFSSPVTTFSGNPSSKDVGQYNFTLNANDGNGTTSTIINLIVSDEPAPQVGMAFSSQLQDPSSRQLASVQIMANNQGVTVPPRWSFSLGWNGNTFKRAEGGKRLFYDARLKSGQPLPQWLEFSNSTFTFNGVAPSGGVFPIVVTGTDFWGYRAATSEFILAVGGGDAVELAGQWQPINTVARSKVDYKIDTSTVTVGGKNVDAAALKVNALLSNFHWLSFDNKTNTISGTTPDDLVNGTVVPMDLPISLASVNASNSLSYLAYTKLNILPYFFTNFTLPNGKAAVNETFAYNLSPYIAADSPSINATVVPAEAAKWLTYYYENRTLVGTPPGNITYNSINLTFMGTVNNVAATTQVFIPIDGVQQPPQTNSSAPVPNGKVGKKSKKAVIIGCVVGIVGGLLVLGLLALLFFCCYRKRKNQKRVSFSSKADSDPFAKRERAQGTPSTLVGTPEAKKKLDDSSISSGTTAQSTPLATPLMPRFGGIGAADGNDDAAELEDKVEALKTRDDSHGSSFVGQGEMIGSVDPNASLNQTPKMKKTAAAGAAAAGIAAGAAVAKVPKSASGQSGPRPSRRTFSGESLASWESQPSFHWSDESNYLPPMALPSDGVPSTANNSVVNTSVIPGVPIPSSETADMLAAGDVARSPAGPIPRPLPGFYPKFPRHIAPGQPAPFISSDNLPSIDFSEFRDDTSRSLNSNSFADSGSPINSANFFPSRSTNALSSGEVLYSGAFTSGGYLSSDEPVIQTAQRQSLEAQRSTIVEVAPSSVVTPPYMASSNVPSPPAPHIPSPLSAEKQRNTQRRVSSQRRPPAERTNSTREHIVGDAPVEAYDDGYWTTDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHH2</accession>
    <name>K1VHH2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHH2"/>
    <dbReference type="STRING" id="1220162.K1VHH2"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440185_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHH2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="321"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="621" mass="69464" checksum="AC02360D085D0EA8" modified="2012-11-28" version="1">MSTSVISPERRQPHLSPAASTSTPHLEDRNATQHRAKKAKTNLQSWEEKKRLHKLKKKERKERKERKELKRLQKLGWLLTGQSAVPTPSPDRQAQSRPRSELRGTSEITASEPSGSPSNSRDARNGLSPAVTGLKAGIEEPLNQLEVTRTSVLLTSTSAPHLSPRTGSTLARASPLARNSSTPASTEPIVIADDDDDKALPEPPSNAPPIPVPDSPIATARPSGSSGLVSAPPPVSPEQARRRRRRDLPVPVSTAAEPIVIEDEEDPDLRLLSATRPTVPVVRQRSRADERFCELYYYGPRRAPVYEKIEGLYGLDEVLVEGGERRIARGPRAVGSGKGFGLRATSDIKNGQVIVHESPLLIVTDSDISGVPALFDALSDEERRICLSFPWTTESEDPFVGMISTNFIPHTGPNGEDQSAIFEYISRTNHSCCPNSHWYWDNEAQERYLMALRDIKEGEEITASYVDEFDLLNSRAKRRQILRELHEFHCLCPGCDVDVVTGRQSDKNRKRIMDLLVRWESVRTTQGINVLACEPGIVEEISSVVHLLKKERIEIHLDYPIEILFQIHAAYGRRELARDTAKVLVQTLRRKAGRRSKTWEEMKWARNPESWHGYGSLLVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHI8</accession>
    <name>K1VHI8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHI8"/>
    <dbReference type="STRING" id="1220162.K1VHI8"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350618_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHI8"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="123"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="803" mass="89308" checksum="27004062F78F7AEA" modified="2012-11-28" version="1">MPFPSKLLSTPVGGQGPVMSLTQHQWDCVNRCNEHFSRDGLVLPVGEGKKETAPLTEREKMFLSRDAYLRFLTSVRGDISACVEKLEKAIIWRRTHQIDDFDEWVRRMKFDSDMGKTFLCHFAPDGRPLLYMLCNRDQLPMNKRHPWLVLFCVERATELMANGQTALINIFPFTKKQGLPASVSVSRTLMSSLGNYYPEVLSRSYVLDAPWQIRTFIGLVWPMVDWSARRKIKICPSEVIFKDGEVPSERLLKDAGGKLDVPWDAEAGARFQRIHCGRHRGGSVGHDGEHALVRRFGLYSPSVNAYTSEHGIKQWKDNWSFHGTKTSPTGARPNMTSTSLESQHGLVQRVQENEKWLKTNPPPPSSLPPQRRCSIQRAEADTLSNSGSSSSGSSVAARAPQRKSSLRAPHHHPHARRYNGSSWTLDSEDEEEPQPRMYPRPPPPPRSLKSFISSSALSTTAPPLPSPPMERARTNSLEAQSPKVTTRPLHRNGRAAATRAATEPGYPYRDEPALRLQPRRQSRDVEKERKITDLLPVSDPEPDIYCPAAESDTDAEPEPITTPENAPDGMDAFTSRVHLRDADDHGIESLSKRDSVSTVDTGTSDGDHSTDYMSSMSSPPHDRWVAILPAAMSSTSHLALEARLEAELQAQLASEGSNDDDATIKCSDVASVKSKFDACPAPLPPSPKHLPPSPTHHKVKTHTIDNTKSWGKSPPARTSPLRVPPRDSAVKGPRSPPRSPRSPGRPVPGMPYLTNPAPFVPHESPPRLPQMQTDRWRFNAPTLGMQPQWATLPRNGGNMRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI55</accession>
    <name>K1VI55_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VI55"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003017_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI55"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1251"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1285"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="71"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="835"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1349"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="658"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1439"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1354"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1373"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1573" mass="174240" checksum="2ACCB195B67AAEF6" modified="2012-11-28" version="1">MSAIPSPARRRASLVGSPTPQSPHSQLPRPQSASGRYRSYGPPPSDPIPSVPSSSNRSSSPTAEDNADKGQVRVVLRIRPSEPEDPNIPSRHRSVLVHPTSSTEVRVSVDPATLAGSASVASTSKRHPTFTFDRVLGEQASQIDLYNVTARERIEEFLRGFNVTFLAYGQTSSGKSYSMGTTGDEEDYLDLSDHSRAGLIPRTVEQVFRRAEEIRLQSGPGASWECCVSFLELYNEDLIDLLSNTNMPVSIRENQDGRIVWSGVREIKVANVSEVMQLLSEGSLRRRTGETNMNQTSSRSHAIFALTLIQTRRADSGNSDAPSGRMTPSRRPMSVAGGNGSRSTTPVFTRAQPPSSYSKLMRPSSMYTGGGAPAPHSEDELVVVTSKFNLVDLAGSERLKRTGAQAERMKEGISINSGLLALGNVISALAEPAKNRGHVPYRDSKLTRLLQDSIGGNAMTTMIACISPLEYNISETINTINYASRARRIKNSVSKNQSEVGWDDIDYLRNTVLKLRTKISTLEANPGAAVRSAGRFESSVDEEALARQVMELTDKLADLEDDFSHLQDQYFEKCREIVALSDPDALEDDKLRQFNETIEPVVLEYEKVVTSLNNQLAMLRAEAAAREQSHEEQAHDLIKTQERLSEHESYVTELQGRLTKLTARNESSEAYIRDLEQKFRNFTDNDDRQTDVIAGLSKEIQDLKAESAKSNTYITQLEQRIATADNRATELADLVERYEREAEERESTVRDLESRMAMVDNQQDVNLLLEELESRERRIQELEDKLSKSKAQTLLAGAAGAATASAATVAVSRSAADMPEDVDEDDDDLSIVSRPSMEAKQGEPEIPKPEEPEVEAKAEVKDKAAEESSKEVAEEVPEKLETPTVKEPEAEEAETAATNGHVEMPREIDLSDDLPEEVEAAGDADITPKKSAVSPTVALAKDVPVPALEPSHDAPKSTSPTPPETPALRTIAEDSESEVDILRKENEALLMRLREIEMRHEMQHPATPALEPPSEHDEELEDEDEERDGDSTTNNKRGSTGNESSESETTLQTPKLASRAVSPQIHTDDPLSLQRSPYAAFRANSIDARRINSERILRPLSLSQSINGLAYMSNSPRYSWSPPANGNGTLTAYERSPKFDRSPKRQSMPFESKPMRSVQSLEIDINLLQKAVTDRDAQLKQREAEIKYLTNGGISIAVTRRPTSRPWKRKLNKEHNTDVYISKHDIDQPPFKERLQTSLLRPFVLMFCEPIILFMSFFLSFIYSLLYALFFAFPIAFEEIRGWNIGMTGVSFVSIIIAKIPAVPKNPREGPALSLLAHSGLRGSGWVKCSDGQCLCSVLSAEAADLKSQNQELSKNRDSKQMIDRSSRSKLPPIGPPPTAPLPPLPAGREAILSPTLTNASLPGRTSAHEGSVESARSSKYDSHDGHAVSLRPESLVTVAEVEKALAEREEALASLTEARDKLIELESSLGSAQKDNEAFTKDLIELRKNNSKLKVRVDDVNREMAELKRERDSLRRDLVEIKNELADCQYERIADRQRLEASKTELAQCKAKLDRMVDAKVSKRSDQKLKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI57</accession>
    <name>K1VI57_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000380">
        <property type="protein sequence ID" value="EKC98821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI57"/>
    <dbReference type="HOGENOM" id="CLU_1070341_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI57"/>
    <dbReference type="OrthoDB" id="10529437at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851883" evidence="1">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="260" mass="28255" checksum="BBFD7E9E56F9FBBC" modified="2012-11-28" version="1">MFGIVDFTTLTAGAALLAGVAAVPSVPLQPAYKWDMIKPDEAKVKQCLSSADWVMEWSGNPINLGNADPVKEFKDLIGSNQCGSVSCHKGTSESLTHKVAGAEDVVDTSYRIEISEAWFNNQAMKDLMTEVVAQGIEGASQWETKHWEHPTRLDFLNGNFGPAGSGDNKEVTLPGDEFTLTWKDIASCSAFRLKVNYIDTRYCGAWTFGTTLTKAFDFGALAGVTDWSQSAAGIDALKSMVQQKVQGNINITTKMQQPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIJ0</accession>
    <name>K1VIJ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000339">
        <property type="protein sequence ID" value="EKD00581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIJ0"/>
    <dbReference type="FunCoup" id="K1VIJ0">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIJ0"/>
    <dbReference type="eggNOG" id="KOG0942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_2_4_1"/>
    <dbReference type="InParanoid" id="K1VIJ0"/>
    <dbReference type="OMA" id="MELSAVW"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="666"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="974" mass="107660" checksum="3C0703748A2A818F" modified="2012-11-28" version="1">MWNPDAGKHGSVDLSTASASSSSGVLATVRAKRLAREQERRQELAALAIQRVWRGRSSARQTRAQLLAHLQDKPIGIEDTGKVLVLLSGDGDRDGFGAIATKWATSALDKDRRPAFVAQLGDDEFAYRFALLLRRLLGFIAKQPRTVLSAQLLGKLVDLIAPPVYAGLEAERRQAFVATLGGDWVKTGVGALREFIAAGQRLPKKKHPLSTPIVSVIMAPIAIAPPAQDSPLVASLLQDLMTLPSLPFSLPLPALTTLSRSLPLFQVLLPAAAADPALLDAGGLSTELAKTHFLSNLATFGITGGMLQRQGAQGMRDWIAVVGTMFSTLGEGWGRWVATSGSEVEPMVVDDSDSDDEDENGKRVARKPVREPLPSNVAARLYSFASPAHLGTLVAAAMQGDSKTLVDFSFFVLGLLNAFRGSARWEATLDAVMEGKRGARMTKLLWREGVRGKWGSGRKDWETFSSNPNRAMLMLLSHIYCHYLLLTPDDEFFSNDTNALTLDEVLDLSTIWRDLAYWGFMEGVSSGESPSRGPGTEEVRSLFTRGVTRVAERKKFAPHNFWVMRELNSDINSFVNAVRYEEASLQGASAPRALRQRELAYIAPRLGLLNNLPMAVPFETRVDVFRQFVRADQMRTRGDNPFHSSRVQAQIRRTSVAHDGFRQLNRPGALRGMVQIQFVNEHGLPEAGIDGGGLFKEFLTCLVKEAFDVERGLWLANDENELYPNPHGYATEPHQLEWYTFWLGRQSYLDDLSSLDAELYRGLISVKNYPKPEELSLSFTVTEDDFGVARSVDLVPGGSEIPVTAENRAEYIQLMCQYKLGRQFAAQSRAFFSGLAEMIDPRWLRMFDQAELAQLLGGEHADIDLADLKRHTHFSGFAPDSSTPTAFWRVLESLSQEQRGKLVKFVTSCSRPPLLGFKYLNPEFAVRNAGSDTQRLPTASSCANLLKLPDYKDERLLREKLLQAIESGAGFDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIJ9</accession>
    <name>K1VIJ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIJ9"/>
    <dbReference type="FunCoup" id="K1VIJ9">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIJ9"/>
    <dbReference type="eggNOG" id="KOG2484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_5_5_1"/>
    <dbReference type="InParanoid" id="K1VIJ9"/>
    <dbReference type="OMA" id="PEILCKM"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000571">
        <property type="entry name" value="Guanine nucleotide-binding protein-like NSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="71"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="649" mass="70463" checksum="079BB5E1606D3439" modified="2012-11-28" version="1">MPKASKKGGKGKVYALPTALKKKDGGVPKLTALRDKRAQAAPYTKGKAVSVDATPIDSSLTVRDSSAKAFMRELRKVIERADVIIQVLDARDPEGTRSKWVEDEVRKRDAQGKKLLAVVNKIDLVPRENLELWLRHLRHSFPTMPFKSSTQGQRQHLSQNAVPLAAPAQQVGEKRKLAELPQTSSSLGAPALLNLLKQYALTTPHSALTVGVVGYPNVGKSSLINSLKRSRACGVAAMPGKTRLVQEVVLDKGVKILDCPGVVLEDIGREYEGEQGRQKQAELMLRNCVKAEIIDDPVSPVEVILQRTDPATLQKLYNVPPFDDVRDFLIKIALTRGRLGKGGIPDLIGSAVSVLRDWNSGKIPYFTKPPAVHASSMPQAQPQREGADVSMDEGEAVGSAKVLTQLSEAFTIEGLFDNIGDDAEWQGNGEEEIEEDGFIPDEEPAPAPAPAAVAAPQPAVQKRMRMAMDSDDESDSDSDVSLGSPVASTSALPAASHPTAGGAFMPVPSRGVADPSRLFAPEELATLGANSDVLDRKRAKQLAKREKKKRQAAEKLELELTGGLLGMDVDEGFRAEMDAIPVPASKKQKLEKRKKKKAALKQAERQQRMADPEFPEELARGDMQMDEARKESDFANFLAQMGADEDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ16</accession>
    <name>K1VJ16_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromate ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ16"/>
    <dbReference type="STRING" id="1220162.K1VJ16"/>
    <dbReference type="eggNOG" id="ENOG502QRJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_0_2_1"/>
    <dbReference type="InParanoid" id="K1VJ16"/>
    <dbReference type="OMA" id="VWGMART"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="57361" checksum="F079914E69AD5962" modified="2012-11-28" version="1">MGVVYHLKEVFKHYWDLGFVSFGGPGVHVIILRKRFVQTLKWVDETVFLDLFALGNALPGPGSTQLAFSIAVVCHGVLAGLLAFFLWSLPGAIGMGILGYGVGRIPDQIPAIVMALLTGLNAAAVGLIALAAVQLGHAAATDKITLVILWLSASFGICYHAPWMYPVLIVAGGLTTLLWDFRRQWFITPAKKLVKKHEHHPQQHGDIPLEAIPERRSPTAPVADNASLRERASIRKTSDTDIPVVPEVSSVPAPAPIHERPGSTRSVSNGIGNVSSTSLRPRASPSEEEAPEPTPEPAQETLKFKVIPTSVACALLLGFVLFLAVPLGVRGGLKHAGKHVSRAFDFFCAVLIPSVIIFGGGPVVIPLLRDYVVAPGFVSDRDFLLVFSILQAFPGPNFNFAVALGVIALTPVGQPVLGAFLGYIGIFATGILLKLALLPIYVNWKDLTVVRAIIRGLNAAASGLVFTAVWQLFLVGYIYSSGEGDKSTSLSGPLTADPFWAVVASGSFLASYRFSSPAWASVLGGGVAGLAWYGVQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ29</accession>
    <name>K1VJ29_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ29"/>
    <dbReference type="FunCoup" id="K1VJ29">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ29"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_3_1_1"/>
    <dbReference type="InParanoid" id="K1VJ29"/>
    <dbReference type="OMA" id="FWYTVSS"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="98"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="532" mass="57005" checksum="70FF1F52A4E5130C" modified="2012-11-28" version="1">MLSAGDHRHRAPFAHQSSSLDLYAQHAQNAPYTPYNEKYVYANGTSNGLPTSPRGASFSAGLFGGLDSLSASLGSSAGDDSLVSRVLAALPKPATLKFITLCTLWYASSAVSSNTGKVILNRARFPITLTIVQFAFVSGLCWLISRRQLGLGHRLRRPTRQIVVHTLPMAAFQVGGHIFGSLAISRVPVSTVHSIKALSPLFTVLAYAVLFRVSYSPATYLSLLPLTLGVMLATSFDISLRNFLGLICAFGSTIIFVSQNIFFKKVMPSPGSGGDVSGPRLDKINLLYFSSSMAFLLMTPIWLWVDAPKLLSLMSAPGSGHAFSTAVYYAINGTVHFAQNLLAFSILASTSPVTYSIASLVKRIAVICLAIVWFKQSVHLVQALGIALTALGLWMYNRAKRDVDRGEKKVRAAEMAREGVLPSNVRDEDMLDPAHKIHKSPRPEYVSNGHAGHANGHAGHANGHSYSQSSALRREFMPPPLSVPPPPPKFKQALPQGPYPSPPASTASSPPLPSTKLDEHPVGLGVGVGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ56</accession>
    <name>K1VJ56_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ56"/>
    <dbReference type="HOGENOM" id="CLU_345190_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ56"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="819" mass="88914" checksum="6DE6AEAEA6AE109A" modified="2012-11-28" version="1">MAKVEPVTPKSEVSPPQPTPHSKWNTGDVSLVTSDHVMFTVASYHLQSWSLAFRETIGSGAKTLDLPYASYTLEQFLDIVDTGKFAVSSKASVLVQIAALARFLSAHQCALATELFVHLVRAHTDWSPIVFFLVGVHLDRPELCAEILDSYPRPEDMFWLCPAPESAVLKPSEIPFEVFAQIPHTYLWALRLTLTGVEKLKVEGFERKPFGAPVAVDQNKVGKVEEVGGEEQQEKVTGEPDGNERDLVQPAVPAVWEEPDIRDEATTQNIAVDIPKSLEDAAMNGYTAEALEDIPLSADTDQAVENMVRIESLGGSPEHTSSVTPALASATEKDTGFNDAMKDDVHDNDLVHNRGSVDNEGSDETIACATVKDEMTNVHNPTTGRATCNGPALTRDRQDSLASLSSETDSCWDSSEGTLRSGTLPEEAEENPLPVQNVQKKDVIVEAVDVGVSPQQAQFVVLESVTEEDDVTANGPQAGSNNGDALSAKVRARDNVADDKAAPAAPLNGEQVIIDPHVPTAVNPEAAVVASRTDLTATTKAPTTTTIPVMTQTKTKLQQQSKRDVKPLVLTLRIAVALPLVVVVMYCAPRPRSMSDLFVPSSSSPIDMSHPINETPEPAVNAKWQHGSFEIIAMFRDMLATCSGPQRMQLEEPSHTIEQFLDIVTTGEFQLALSDDSGASTALVQLSRLAKFLRKYDCPVALSILRNSVRYRADAALIALLLVEIPDKPRLFINRLDSFTGDENCLWVGGNTPTTSFKPKAVPLEAFAELPIQYHWALRHARVGNLERSVIQGGNNQMMTPGQRFQCLLESAQAAGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJN5</accession>
    <name>K1VJN5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clp1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJN5"/>
    <dbReference type="eggNOG" id="ENOG502SCZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059618_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJN5"/>
    <dbReference type="OMA" id="MATYLAP"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="38951" checksum="C9F93DBCCF94EBE3" modified="2012-11-28" version="1">MPLARISSNKENSFCRPAAAIRAKAAKVKAKAGLAAGLGLGLPSRRHKRSTSIQRAKAANSKPKANAKLQSSNASHAAPKSSEGYIKLPLNLSRPALPQVAELELEGDLVPSAFVVDKLQPILSGMLLAAALFQPYPGASKSRTEGRRSFAFGLPRSVSHLNVSGLEPDLCLALHRPGSTEALQIFPTHRLVYTSQCAYFPSLPLSYPSDEEEHGLETIPEDDASVCSSAPSSDASDASDAESDDDSASEASADLHAPSYLHLPVLGLEVPSPETWELVHVRLHSSDEYCWQKQLLGLPAADTPAAARKALSVLDAEELFKIMRRVHGAWQNCCAIGVTNEKVWEQLGSAWAVVIDVIKARATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKG2</accession>
    <name>K1VKG2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKG2"/>
    <dbReference type="HOGENOM" id="CLU_1086608_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKG2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="256" mass="28059" checksum="5081E4E060E20198" modified="2012-11-28" version="1">MFTLSVKSNFPRTDWSGQPPPPLAVAAKSRRALDRIEYAARVASQRWALLADRGRLEYVDTTMYKLAVLDKVFEMRRAGLKLPRVAGASGPLRPQSHGPDALPEARRPSPAEEAEVRAFVMATKDFGYRSWADAWGGVPPGHLLHFDYELLGRYDPAREDIPGHIPEPRHLDPVWDGFVGDLEDPGGGGVAAAEGGEDEDTSVNLVGTNSDSVCFPGRERGWCHLLSVAIKVCLVVAIEVWCLQGLYSTLRAALFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKI2</accession>
    <name>K1VKI2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_08445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKI2"/>
    <dbReference type="FunCoup" id="K1VKI2">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKI2"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_1"/>
    <dbReference type="InParanoid" id="K1VKI2"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC97287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="53199" checksum="E6E3F324CF2584F7" modified="2012-11-28" version="1">MKLPMSAPKDAVKYVLASTFMLTPGSRLSKAGFQQISERNPKPSSLAAGGKYYYTRNQSSLVAFTLPPKGTAPTAVSFAVGHVDSPCLKVRPISKRQKAGYLQVGCELYGGGLWHTWFDRDLSLAGRVIVNTPGAKNGFTSKLVKIDRPILRIPTLAIHLDRGVNDKLTFNKETEFLPVLGLVNEQLNKPASNNPSRAGTPKPDTKKDDGNGRADATSNEERHHPLLLAVLADELGCSIDDIHDFELCLYDTQPSAVGGLNNEFIFSPRLDNLGTSWSSIEGLCEAVEAEGKSDSKEPNVRCVILFDNEEVGSVSNHGAESNLLPSFVEMLSRLPSSDKGEYQILANSYLISADMAHAVHPNYESRYETNHSPKLNAGVVIKTNANQRYTSNAQTTFLLRQIAKRAGVPIQDFEIRNDSSCGSTVGPALSTHVRTVDIGIPQLSMHSIRETCGSGDIRYYIDLFKVFFEEFSQIDAELKVDDQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKT5</accession>
    <name>K1VKT5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKT5"/>
    <dbReference type="STRING" id="1220162.K1VKT5"/>
    <dbReference type="eggNOG" id="ENOG502RSPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_1_1_1"/>
    <dbReference type="InParanoid" id="K1VKT5"/>
    <dbReference type="OMA" id="TAHENII"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="564" mass="62673" checksum="E5D97538BD9C9FD9" modified="2012-11-28" version="1">MRLLSTLPPLGTSPFASFSFASLSPPTAPRAAHSFKTTDCHHSTTTRDFHCFVTPPPAPPERTTTSQSQGRRYSMASPFPSRPTSIDGVHFVQRRDLNPLRHRPHKFAIYFFNALRATALFRIWHMLVFLGGWAAMVVLVSEKTKADLGIPTTMITVRVLLGLTLSYRTSSAYERYQEGRRMWALIILASRNWARTVWFHCPDSMSGNPPSDPQAKAQDEARAVIEKKTIVQLALAFAVSVKHYLRGEEGIYYEDLFHLVNFIPSLDLPSGMAMGNATIQPDLPSLSSNHPGYHTRPMSTLSKEPTYVSPETPGYLRPADDAPGFDWSSLFRFHKKNKVADEEKARQAQRVETAPMPFGCNNIPLEITMFMSSWVATMEKRKVIGVPTINQLNLCLNQLNEALATLERILTTPIPCTVIVGYIIIGYASIAEEIEQPFGYDRNDLNLGYFCRHIIARELDAITARPLVDPDEYVFTSKNRPLGDCEPSADRLVEKSVEVIRSRLAVTGLVGSATTAKASLAYPETQGNLANGPQRNDTRTSLSYAQKTSPLACVPPMCSSSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL61</accession>
    <name>K1VL61_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL61"/>
    <dbReference type="STRING" id="1220162.K1VL61"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608573_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL61"/>
    <dbReference type="OrthoDB" id="2593586at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="450" mass="48150" checksum="2C803DD9E5B7BCE2" modified="2012-11-28" version="1">MLERNAFSDVRLWPRGVDLEQFGPSNRSQTLRDIWGVGPAPIAPLPPSPVALKKLAHGLPPTPPMSPVVVPAAPSLASIVISTPATSSPLTPISPAQSTASSVAGDEKPDLVILYVGRLSWEKNLSLLLHAYSLLPSRPKLVFVGDGPARADLTAHCEKHGYDALFTGHLSGPALAAAYASADVFAFPSFTETFGQVVLEALASGLPVVGLDAEGTRDLVAHGHTGLLLPMPMGPGEQAKGKADLKGGWASACKNLDADSRLVQTYASLLASVLRDGEMRRRMSANAATDGIRGFTWWDAMEACVDSYRESIRAARRQRTVDITVSSPPPTSAPYSPYSPFSASPYLNSTPASSVPTSTTPAADPAFSPTLSPNMPPRQRRHEAKRISRVNRVVSRRLARKEHEDGPAALALKTLAKLALALGVAYWVWTRHLGQMGRELGWDEVFRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLE3</accession>
    <name>K1VLE3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Formin binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLE3"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253786_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLE3"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="758"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="849"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1350"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1350"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1400"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1409" mass="159020" checksum="363807739E3EED01" modified="2012-11-28" version="1">MNGPASSSTPAANGRPNRPLVVKAGYDGATRRVQFPSAATARLESLHSRIEECFSLSAWPFFLSYVDDDGEEYSVRTEDDLTDAIAYFVSGDDDHSSLYSRSGINIPPSKITLRLDVVVEYDGPSLSDTSSIASFPTSDGSSFMSRRSGLSSDSRLSDPYTSHSGSHGYRADPNRLSDYSRSDYTERYDPRYYAASRRSSATSGTQRRPVVDRELASVTDIFESAVIDDGASALTTSTTPNFTQSELGSRWLREQSQIASRMPRLRLRRREFEDGDPDPDASDEEIGDISLVRDARGRYYYSYQDQASIADSASLRSVPPPAPPKPEGDAGPPTLAPDCSACGLRLEYMRYVCVSCGEGDMWSQSAPDNRLRLAARVPPPSIPSDSDGSDSTAWGPAPVPGAPGDSSACLLQPRSRTASMSTTSSSLSIAVTNGSASSPTAASPRLPDGADEIGFDERQYTRRGYELCPGCIETHGIVHAKAAAKGKSRDRHGRRVRGFRHTFREKIWGNGKWVDVEYAEDSECTICRTPLMHNRFKCVSCSKFDLCRSCYQKVEEIHPVHAFLSLPDKHVVPAPPRVAETRPPRHHGAFCHNVSVMCEGIGAAGDGSHTADHIMIKAGACAAGESSTASAAAPDSQYKNKVGQVPATAPPTHDPTAYLNDQIRGVWLRCAHCAAGFDMCADAEQVADHDVTHVFVVFKARVDMTRFRQLADLAATHSKPLLNQQRPITSQAEQGQQHHSSPTMSASASPASALVPGTPGESQWREYKSADGRVYWSHALTKQSVWEKPDELKVSYRSEAKLTIQTPFERAMNKTPWKQFTSKGKPYYVNSLTKETLWDLPPELVELKNKIDEQERRKARGETSPAPSARSRSPSPAGSSPGGALQRYRSPSPEEEEEDNEPLVIPHGGFKNHAEAEAGFMRLLKRIGVDESWTWEQTLRRIVVEPMNKALETLAEKKAAFEKFLDNQAKERAAAKEARMAEVRPHLRKAFKAAHIKSYHTVKTGEQAFASNKHWRRALPDERRILLDEYTSELRQAEAAEARELKEYATSKLSDLISTLDISVTTKWRAAHDVIVRSSAFKEDSKLGKMETIDILNVFDNYMQRLEREHQEESARLAKEHKRRARKARDGYMELLRELREQGKLHRAAKWKDVFPIIRKDPRFEALLGMPGSNALELWMDAVDDLQVEAEERAGRIEGEIPKNRVTLETTREQFEELVKEAGVEAPAENIKEAFDVIHERLARVKADEERRAERKRRHRIEDLRDALRRIRSITADTTFEDATKDMSSIPEWKLLEDADRRSAFDKHIRRLKEKASERDRDRRGDRMDVDRTERDWRRDRDERYARERERDSRRDRGLDYRDPRDRDRERERERERERERDRDRKREERDPKRRRVSTVDDEREEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLU1</accession>
    <name>K1VLU1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLU1"/>
    <dbReference type="HOGENOM" id="CLU_074425_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLU1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="403" mass="44557" checksum="82E3CB898FA5BD19" modified="2012-11-28" version="1">MPTIDLSFYPHDTSASAMPSIDLDYYPHITDALFAFAPSASLKVMRGVCRSWRSRADAALSGHISFRATYTCYDEKGVRELSLRLSSVRDPSVGTIFTLGLKTKKFSSRSTGLLPSAIRVVDIDAASHKHFALTHSMFPIPFFERNSQTTSLRAEYEVFKNHIFRHLYEADPIAAETDEAEMGQRNDRTVRYAVLDAETFCYPLDVGCIVLFAQNTTPETKATAYLEQIGRLRLCGPGKAVLHLRHPGSVDGSVRAEMDDITIFVHPWAHLKVSYDSVAEAVPNVLGTLLDIVQGVQSYAKRINVVGLERLSPASLGLEEFDEDLGDAVVGALEQLSKPVAPAYQHIPPGFSSQPCADPLAAILPELSGCKRRCTINFYSVQAYRCMVGREQFEIDTNEGALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM12</accession>
    <name>K1VM12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM12"/>
    <dbReference type="STRING" id="1220162.K1VM12"/>
    <dbReference type="eggNOG" id="ENOG502S5E6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078557_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM12"/>
    <dbReference type="OMA" id="PREYCCC"/>
    <dbReference type="OrthoDB" id="2552042at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="30602" checksum="2D0CFB127550AE99" modified="2012-11-28" version="1">MATGVLCFAAPAVVGASPSPMWLSYLLGVICFVGVLVQPIGFFGVFREKTTTFKWYITLNAVATYVALAVAAVIVIISGVKHNTAVANCKSTYYAPPDEIRTMSGPLEILSDQSDPICMGFCWADLGMMAGLWAICFVMQSYYVWASSKYSRSQVSDHKLYHSVYSENPEAFTMSILQSRRYNPDSVYFQNPSTPGGLHPNDAWDHRPSYDATPAGTPPHPNQQGGQYHDQPYEGYSDQHPNQFNDRYTDDITPGPPQQYAFTQPHAGYVDHSNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM60</accession>
    <name>K1VM60_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM60"/>
    <dbReference type="HOGENOM" id="CLU_2335137_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM60"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853916" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="98" mass="10321" checksum="48ED5C59F41AF629" modified="2012-11-28" version="1">MKLINVLAVLATAYCAVAQVGAGQDENTHEGLGLELCNRVQNEGMDCSTDRESLITALGTGGLILLDKASREGQGPGTPDYDKGMRMQQLAGDLRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMK8</accession>
    <name>K1VMK8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">A1Q2_03755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMK8"/>
    <dbReference type="STRING" id="1220162.K1VMK8"/>
    <dbReference type="eggNOG" id="ENOG502S63G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410031_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMK8"/>
    <dbReference type="OMA" id="HENTEIQ"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="670" mass="71037" checksum="DABB664D93AF4896" modified="2012-11-28" version="1">MDVEEKPPSAFKDVSLTVDGYVLDARKLRSIEADGTLVYEEPKPPQANETETLQRIWDEVPGGFLDLTEEGLRADGDEFPEPEEEVKVEEGEKGGLMSAEDMEALRTEVCSNLNDARNELWFVFELAKTLAASSGMTSHPPPDPIPASAPQPKKKKGAAAAAAASAMASAVSTPLPSGPESELVLPAGTYSTTPGTASEPPVQLQAEKLETALRARSRALDECSNLIDAAVSELELMSNASERFASDLDQLRGKELWAIVPKPEFGRASTAPNARARDVVIPYALDEAPAALHARSLAAFDLDPSKPEMAFGARSFLRLRFLLRRGADAPTYSSAVYDASKEEGTDVCAVLRAAQAETLDEDLFHELRAEALRVDGARVEATSFTLKVGKDKLTAELYDSRSPPSTPRGELAEMLLATARLNMLHGYRRRKARIVTGTGAPHPPALVTLLSLVQFMGALDAIRPTLETIVGTLKQAGLSAHLAERHACADPTVSECLMTARAKYDVLGVVFSLDLAPGASEASRNWGGAVAAHNAAISQLGGYGPSTGGSGGRGFLSVNLTAPAAITVVVPGTSFPVKDLEALGGIVAEHAAGQIAPLLFRGIKGQPGAFYDELERCVVLGDRGPLTLEIPAPHTSLIATVDGERYDSATAGVGLEDWLKSLAGENGFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMW6</accession>
    <name>K1VMW6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMW6"/>
    <dbReference type="HOGENOM" id="CLU_1225529_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMW6"/>
    <dbReference type="OrthoDB" id="2558705at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="25149" checksum="42553FC2FEB20FC1" modified="2012-11-28" version="1">MFFGVGVAGRLPTRDRQCFLCLLADEQYPSLNLSFTPLQQSSRKTHGENRKRNDNEHPQRPVTDLELELCRKRQQADRPQPERDPADGADGRGTPRRRGDPEHRPEGGPGAGDCVHEGGADGQVRVDFRQPLNTDYPTSVSQPVSAACLLTGKADSRYTFDSRPLQSREGDKVQKLCRKLPNGSTSCIILGLETEKLFMTMQGQGYFCALPAEPNQTHMECVKIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPA5</accession>
    <name>K1VPA5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPA5"/>
    <dbReference type="STRING" id="1220162.K1VPA5"/>
    <dbReference type="eggNOG" id="ENOG502SEY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1562700_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPA5"/>
    <dbReference type="OMA" id="FRTANFI"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="11">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="175" mass="18667" checksum="F491E453E6901583" modified="2012-11-28" version="1">MNQGPTQQQVNNSYYPGLSEALKRARRPYQMRNLLTGGAVVAFILGVYAYSISAVKQDDFSDVVDLLPPAEERALVKTIEDEQREAEAARLGSTSTSSTPSSTSASSSSSSPSSASGKSGVASLLPRRLSDIEWVRQRGLVEPGRDNVLVWGAPSVDNIGNMRQNPGTTPGSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQB2</accession>
    <name>K1VQB2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQB2"/>
    <dbReference type="HOGENOM" id="CLU_1225523_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQB2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="26065" checksum="2BD3E479A7843403" modified="2012-11-28" version="1">MGNTFSLCSPFRRRLRLQDSGHEKLEDPLPQPQFLFPSEEYPKYALLPSSEEPYEVRFCTHTPEPDSGRCACDEWTESRHWRLVAGLDDATQPGTFEALQPKPRSNPFEKAEVQLAPDVVPPRYALLSAAEMPNTVRNCVHVRYEGEERCDCDQWLESRRFRVQNGLDNPEDPDVRRGLQSKPRKTPTIRVKRRRYTSISIPKDNSDDGHSPSSTHSRNSSRNEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQD4</accession>
    <name>K1VQD4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQD4"/>
    <dbReference type="eggNOG" id="ENOG502SDEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_746369_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQD4"/>
    <dbReference type="OMA" id="FRIPCTI"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="355" mass="38799" checksum="57597719335357D5" modified="2012-11-28" version="1">MGGNAFGTPAVPLIPWAYDRLLAHITQALSGLELAVPPPLPKEEHGDVDVLVSSSLADFEGDSKGKPAASYTDIAQLESLGDVDSVCSELCRRMGGTMWTRFGRVVSVAVPLSIALPSVPPPDPDEFHQVDLILVPPRSLAWAQMEMTYGQAPQLLKHLCRTAAGGRMSVQATHLGFLCQGPQKRRLEIELTTSPAQLCAWLGLKPYDPHTFHNTSVTSPTTDGVGTGTAAEIARMEPLFAWLGSAPPASLAGRAYARLVEQWEHGGLVRRTGMVPPLSNRQKKMKYDDDVAETFCRWLAEHRRGGTGEDLPSREEENVDEDLQVCRARCPELGDEAIRTLLFFDKMETYLATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQK1</accession>
    <name>K1VQK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQK1"/>
    <dbReference type="FunCoup" id="K1VQK1">
        <property type="interactions" value="699"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQK1"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030821_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQK1"/>
    <dbReference type="OMA" id="CLIKTHI"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="274" mass="29783" checksum="40546B704FFA532B" modified="2012-11-28" version="1">MVYPTTVKTYLERAASHPNAAARKLLEIMDRKKTNLCVSVDVTTSAEVLEVVRNVAPAVCMVKTHIDIISDFTPALTEELAKLADEFDFVIFEDRKFADIGNTVALQYSSGVHKIADWSHITNAHPLPGPGIISGLGTVGKPKGRALLLLAEMSSKGNLATGEYTKTAVQMARDAGRDWVVGFIAMGRVDAEGDPEGKEDFLILTPGVGLVAKGDKLGQQYRTPREVVYDSGCDVIIVGRGIYGVQGGREAVLAEAEKYREEGWKAYEERLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRT1</accession>
    <name>K1VRT1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRT1"/>
    <dbReference type="eggNOG" id="ENOG502TKKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671186_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRT1"/>
    <dbReference type="OrthoDB" id="2562427at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="410" mass="45949" checksum="40B2325E2BF11C14" modified="2012-11-28" version="1">MLGMFRVEKRDDYAYRRYDMRSVGVGPTKTTESAVRGRERSVRQRETELVQGAGPSVAEIRREFNRASAVQADYYEDEEDYPDDDDYYDDELEVVEGPLAARDLVRRLDRLEALDAAAKAYDESFDLRDLRDFRDLRELQLSDGEISHPPPYPDSRGSPRSHSPPRNRPVLTTIFFSFVNRYIAPHLPEDIQAILHDPPSLNDPASLVPLLRAAAPYTQYLLVLVALYVVWAFVTGIVFYLGRFLRFCFRIGPVLAIIAWVMASTGQGGIDVLFDALKAYAGEGAGNNRQAGRYGGAGGAGGVPRGAAMYEAGRRTRRRGPGGGERYDAREARGYYNNPRTRTRRNEPQEAGAGADMLSAFFNNDGLAGTVQEFVKRAVAKGTGLDWLFNQNQNDEQRDKRDGARTTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS19</accession>
    <name>K1VS19_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS19"/>
    <dbReference type="HOGENOM" id="CLU_772055_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS19"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854323" evidence="1">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="361" mass="41766" checksum="5A888E5747B5B792" modified="2012-11-28" version="1">MQEHQVFPIIHIFTLVPLVHAPALPVEIVAMVLELVPRETLLSALRVNSTWYSAALPLLYAHLWFDPKGPKPGQIRTEHLHCVRTLDIYNHGIEDCAGLVFAKSPQVIRIHFRFTLDMMLSHSGHGGRKCPLLELEPETVVFLDYDGLRTPSRGRDKAGDILLFPNARERVLVWDISQGFYDCLGARPIIFPDRPDDVSLADMVERLERKETSLKDDPPTPRRTEVVIFANKTSDGIGEDDLFPWMAYWTRARVRTRRAVVNLRAFRPNDADFACDIGLELWEFVRDMGIECLPFEGEFSLRLKYQDLLATHHARWYSTREYYREARRFLTAREIRALLPREYLWQPACSHGGESYIASYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT03</accession>
    <name>K1VT03_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT03"/>
    <dbReference type="FunCoup" id="K1VT03">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT03"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792703_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT03"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="103"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="246"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="350" mass="36069" checksum="24AD300EC6B3435B" modified="2012-11-28" version="1">MVKAIAVLKGDSNVSGVITFTQETEGGPVNVTGKWMTGDIPIGPASVQCLSDDSGLSRPLRPHHLLPFPPSDTTDLQINGLDANAERVRTIFFNNKAQALTRRFGDNSNGCTSAGSHFNPHGKNHGGPTDAERHVGDLGNVKTDGSGNVDVNITDKQISLIGPYSIVGRSVVVHAGTDDLGKGGHQDSLTTGNAGGRAACGVIAKTPRYALSPPPPPGTSADITRLPHPPVRTIFFNNKAQALTRRFGDNSNGCTSAGSHFNPHGKNHGGPTDAERHVGDLGNVKTDGSGNVDVNITDKQISLIGPYSIVGRSVVVHAGTDDLGKGGHQDSLTTGNAGGRAACGVIGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT51</accession>
    <name>K1VT51_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT51"/>
    <dbReference type="STRING" id="1220162.K1VT51"/>
    <dbReference type="eggNOG" id="ENOG502QW31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526966_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT51"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="517" mass="56513" checksum="2D9EFF0781E16E12" modified="2012-11-28" version="1">MPRAPDMCDAQLYVLALARPALAPGMPGPHPGVWHRLSARRPKRANIPSRQPLDRTKTLHCLKRSQEARQGRASDRTLTWPGSQLRASANERIQGGSPQPRTHCTNSQAPDTEYDRIEGERGSLKLSHPSLMLDSPLTSRLSPLPHPLPRTDCRASAVQRNRERIPSEERTTLALDPAASLRRTTSIYPLANLAPSSHNTRPLRLTPWTLSSLFSFSSSFFTTNCSLCNMWASVLALLAVPAVSAQVIPTGPNGPTNPDHPEFIPVGETVNQGSLSRLISVNAIDDFCMYAPMEPGPDSTIGNHEHDLVAWCTKPRNGARLIPDGTIHAAQFIRTPAYVQVAGWWDGTKLNIPHGDNGGELDPHGATGDGNPVGGNVTTNIQGRQGDTFYEEWMMFISYDQFCARICTAEVNGVTVAKQCDHIYDLMGCQWVMAIDDDDYYNMNKFESCEGDIAAAPGVYGASTFYQGQHPTPSAPAFYPKKSNCHTWDTISNGVGGDMKVTASPTLFQNQKCPTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTB1</accession>
    <name>K1VTB1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTB1"/>
    <dbReference type="HOGENOM" id="CLU_1687969_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTB1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="156" mass="16662" checksum="E647A0D4C6A7658D" modified="2012-11-28" version="1">MSSRSSATPRSNLSEYQSRRASSSATPINPFKPAIKAARTKSPQQPAAGPFSGMRRGEPMAVKAEPFTQAATPLSSGHPSSASSSATPVSPAPLQPRRTVSSATPGGSAKLEEHPRERLQSWLNKYMEEKMAILEQRLSGGDSDEDPEMADMKLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTB2</accession>
    <name>K1VTB2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTB2"/>
    <dbReference type="HOGENOM" id="CLU_1012612_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTB2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="275" mass="30317" checksum="42AE49CD2AF46190" modified="2012-11-28" version="1">MADLPLEENELDIPYLSRPLEDLLDNSGAIPRRPTSTRFANRTSATRTQASHHGSIRVYGEGEGTGRGHDRPVDVENHGRGGKYKSPDDSIPADSSTEIHVWEDGVGAHVHHAAETATARAVYLRAQAKLLQGQDNRNRLLAFARTNGWCALCPLHEVGYVMSERTENSTSMKMGAKAVGVGQGITLANHIRTRHPDDWERIQRGEPPIIRSATSTPNSTPEDKRLMGEALGRARQIALSHQPVVRGSFSREALDAHLTNQRTFDNWFISGVAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTE1</accession>
    <name>K1VTE1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTE1"/>
    <dbReference type="STRING" id="1220162.K1VTE1"/>
    <dbReference type="HOGENOM" id="CLU_1129755_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTE1"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="27337" checksum="D081A8896F565024" modified="2012-11-28" version="1">MIEVLTDAYMTHKDFLELWSEEKIVIHILMTSLVCFFLEHHEAWVGEVDGTIQGVALYVPPGRDFMRKGDHEIVFGPALSMIGKRRQTFIDRELMPTTSARVESRFPGGAREWCYLAMFGVDPMWQGKGLGSRIIQHKNKQLKGTPMCVSTQSSRTVNFFLSNGFDVRIEHKFELAWGPTWFEWFMTNPGSAETRAAPAPAAVSPIQPKKQLPAARPQAKGCNGAKVNAAVAAVSPSRIHAAGAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVR0</accession>
    <name>K1VVR0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVR0"/>
    <dbReference type="HOGENOM" id="CLU_967051_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVR0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="31373" checksum="9C4030D0F6FF22CC" modified="2012-11-28" version="1">MEEIPSPGVPNYVSELVSYLSRRPELQGWVPDGTLLALWLMTLMNRGWGGGGGGIILDVDVSSSRRPGGATGRATRQAVTSVFGFRTKLLHLNAHSTASSVSLTGAQACVVTGLEHVSSPVAIKLRREVEGNDALLIWVRDEDYDAFPPWLLSRSATASLDAFVRAHTVLSSSFHLPPGWREAMAAWKKRSGRSATPFTVGEGGMGDWASKAGERPKPAAVFGPETQVEDCERRGGENMLYALEGSAEDRVKHCKLPHVGELDENDRRAAQKRREDLDEDLVDILEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXC9</accession>
    <name>K1VXC9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXC9"/>
    <dbReference type="STRING" id="1220162.K1VXC9"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="K1VXC9"/>
    <dbReference type="OMA" id="ANEFDIG"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19080">
        <property type="entry name" value="AKR_AKR9A_9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="75"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="414" mass="45759" checksum="EEB8A405A29D02C8" modified="2012-11-28" version="1">MSSTYFTEQKASDYPPSDAVLRTSNSLSHFLYSECPTPVELTAAVFGFFPEAPPPKTPLAEYRVLSPTASVRVSPLCLGAMNLGNQWAGLGSKMSTADAFAFLDAFYDAGGNFIDTANSYQAEQSERLIGEWMQARQNRDSIVLATKFSWFYHYRMDRVDPGVNVNFQGNSAKSLHVSFEASLRKLQTDYVDILYVHYWDWSASIPELMGALNDLVRQRRVLYLGASDMPAWVVAACNEYAKARGMAQFVVLFSLADRAVEEEVIPMLRHQGMALAPFGVLGSGKFKSPEALREQEVRGTKATDAEIKLAEVLQGVADELSTSDMKVTVPGVALAWSRQKYEHSIPLIGGHKIEHLKSNIEMLRIKLTPEQMATIDKASPHHHMWPQTVIGGDPRGLGGKSDMAMSSLGGHWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXS2</accession>
    <name>K1VXS2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000110">
        <property type="protein sequence ID" value="EKD05351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXS2"/>
    <dbReference type="STRING" id="1220162.K1VXS2"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070631_1_0_1"/>
    <dbReference type="InParanoid" id="K1VXS2"/>
    <dbReference type="OMA" id="SANMESK"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="118"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD05351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="232" mass="24545" checksum="A28B19572538610E" modified="2012-11-28" version="1">MSEPKRTTKETHPHLPPGLILDKDGKVCKVCNSWQDFAGIKVYKKDPNAKGGSSSGSSGSGSKAGAAAGGMAGMMAAMSAGSSGSGSSSSSSSSSSSTPATSTTSSASAAKTQDRSECPADTVELGRSTWTFLHTTAAYYPDKPTPVQKTHMVNLLSSLPSLYPCTWCADDFGESIKANPPQPAVESATKLNEWLCRRHNEVNKKLGKPEFQCDWKNIMRRWKDGPEDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXT1</accession>
    <name>K1VXT1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXT1"/>
    <dbReference type="STRING" id="1220162.K1VXT1"/>
    <dbReference type="eggNOG" id="ENOG502RYE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319626_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXT1"/>
    <dbReference type="OMA" id="ANTARYQ"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="482"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="920" mass="104277" checksum="FD3B244A9B1AC59C" modified="2012-11-28" version="1">MLLPAIAVRFALLDRDEPSCRFVVAILPIPPSPRLPASAIRPLPRSEQSLVAVNLLSSTSLRHCGLVADLAECEEGEEDTRKTHHEHSRGPREPLSGAPGAAESETAQLCCRGENPNEASGPVINEMRERLTAIETMLLRFGERVGRSRSRSRSYDRERDHDRDRHRRYRREFSRSRSPDLDHDRGRHRDRERDREHGGDFWSDGGRDRSDRPGQISYARDTRDREWEPRRVAWDDRGRTRDMSRDPRDEPRQLNRQPYSTSPIHQRQEPQDNYGTLVIDKSGRSKWLGPTAGTEWLKNVSFTVTPQADMQQELSSSARPRSTSPQSSSPTRVDESGGLFPFPSWGPPPTMDTLKSHLPAPEVAKDLLDCYYENYAWNHDVAPRQGVEPIFNKVYEYSDEPLAQRVHLQQLALLFIIFAMGALHNPELPPHHPSAEHHLAASRWCLVKGDFMGVNTVPGLQALVIMAHYHLETEKGRSGDSAWPLWGLAMRLVTAMGLHIDGERWNLPDQVIQDRRHVFWECQTIDVFQSNCFSRPSSLRSEHIDTEFPSYPSTTPHDASWSDNVFRQLKFELCRISGAVLDQAMSVRSTPYSKIGQLYDRLCTFERQIPFNLRCRTALQALSSVYQDTEAAIKDSPNIKLDNLHLTFQQFTLSLNVSETIIFLQRPYFIKALQENPKDPTKSIYGKSYLAIVERCTVIIEVVAGLYECFPRVTARHWFFWYHLFTAAICIGTMIIKNSSNPLSQLALVQIDHAIKLYSSVIKLNPTPSLIQNHQWLLHLRQRALAASEQESTGSSSAPRESTEDDDDDDIDVKLMGWRTRLIQRATAAKKYTPPPSTGVPAQPPTAPVPQLDAVLQQHMLQFAPQSTDISTDLFFWDPTIMLGSREDAGNNGQLVELGPDTAHGQRGHDGDAAVVSQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY01</accession>
    <name>K1VY01_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromodomain-containing factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY01"/>
    <dbReference type="FunCoup" id="K1VY01">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VY01"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001499_4_1_1"/>
    <dbReference type="InParanoid" id="K1VY01"/>
    <dbReference type="OMA" id="KMNIPHY"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="219"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="410"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="604"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="80710" checksum="763EF7A29F3BDC98" modified="2012-11-28" version="1">MSAETAPAGPGASEVTVTATPPIDKPLINPIQTHTPPPSSTIAEAPRSPNALNPAAARKSKSASPVKQSSPLVNGSGAPASRASPSAPASKASSAGPATGSPLPGAFPTPANTSFDPAQPSNASNATAMDVDSTDSNSLKRPGEALQAGEVKRAKEEHADGQDSAAGTTPIVAPGADPNAPIVYPWTNYVEPPPRDPGPSTRLTLPQFKHLLSTVRSMLKSNNSFNFREPVDTVRFNIPHYHQVIAYPMDLGTVETKLVASDPRGPPKDKAKAARWDTSKGTYNSVAEVTKDVRQIWENTRKFNGRDHVVSQAASKLQDQYERALRTLPSDNLSHAASPSASSARRASVSQPPQIRRDLDSSRPKREIHPPPSKDINYDGPSSLRKPKRRSDPQLQWAAKTIQSFEKTQKYFEIASPFLYPVSEIIAAIPSYTSVIKKPIDLLQIKQRLEDNVYEDVQQINNDFRLMISNARQFNPPGDAVHNAASALLQVWEEKWRSLPPKQEIREQSEDIAEEFDDSEDEDKDVVRLKEAKAERAALDREIADLEAKIARKPAKVKKTAKAVPKQAKAPRKYSSTKTSSPGGANGVAKKPRKQKETPVYRDDDDSDAEEQTITIAQKQELAEKIQSASMEVLAQAIEIIQTSTNISGDQEIELDIDSLPAATVLKLYNLVCRGRKGRGKKGTGNNKAPAGGRKHLNEKEEADRIRRMEAQLQSFEGRGGGGAGGANAYDDESSDEEESSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY65</accession>
    <name>K1VY65_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY65"/>
    <dbReference type="HOGENOM" id="CLU_880504_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY65"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="33397" checksum="36DF5DEC6297676F" modified="2012-11-28" version="1">MGKHWNVARKLWVTDAMVNQATAERRVERWREHIPSDGSACRPSAPPSRFPSFAEGATASGPVSCNTSSGVAATSHSTTNTTFETISNSAGRAPIELGPNCHISDVSRTEVDAASAAGSAHDDSRELVEVQTAKSHTVQRIPTGHPARAVVLSNSSENAVSTIPAPATPERPPRRLYPVPPARQLRRSPRNGVSGKAVSGSVNSEGNTADGNGPDEPQAVVAGEAPPLEVLQRSTFVPMSGSFRGPGVPGHLVLPVSPPARPPRSPNRPQGLRRQPTEPLCIITDVQLKSRSSSAGSHKRRASDESEGNDSKRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYE2</accession>
    <name>K1VYE2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYE2"/>
    <dbReference type="eggNOG" id="ENOG502SCWF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183929_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYE2"/>
    <dbReference type="OMA" id="NLTMQMA"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="93" mass="10077" checksum="0F1A1FA3D50A2253" modified="2012-11-28" version="1">MASYDDIQGAWGPPTAPATQSADADVSVADAIQKEKMIKDCLNLRDGLRGLLVRITEVQADADKLAKDNEFLGTYIDNLTRNTVVAAGQNQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYG8</accession>
    <name>K1VYG8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conjugation with cellular fusion-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYG8"/>
    <dbReference type="STRING" id="1220162.K1VYG8"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019536_3_1_1"/>
    <dbReference type="InParanoid" id="K1VYG8"/>
    <dbReference type="OMA" id="YHRDISA"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="658" mass="68197" checksum="8E574773189AABA8" modified="2012-11-28" version="1">MYQSSQQTPQQQQVPLSPHPYKVPARNTSSGSGSTPLNVGLASSPSNFDLEPITYPAHLAQTRPPEVGGIVQPLTAGATGSSTATSTSGAGSPNTATGGSGATSPGAPAVPARSAHRYHRDISALGSGTAALASAMNLTTSGLAANAVNTPAAPPSNSQSAATPSIGGSGFASQNGGTMGGPSTATSSSSIAQSQQQPSMGGVSQGSGDSTPTVGPSGSGNQPSGASRSSASRKASNNASSSGRRAASGTATGADKDGEDGSADDVQGKRRGEGGVSRSSRRPPKARERDHANAANLEGEGDNLLSPVLPTAKVPRAPASAMYFSPVAAHGRPPGQALRAHTGTLVGDRMWFLGGVDARSCWRGVASFDTESLQWSTVETHGESLPPLRAHTTTLVGDQLYIFGGGDGPTYSNDVWVFDTVTRRFSRPVIATPRANLPPPRRAHTTVLYRNFLVVFGGGNGQAALNDVWALDVSDPSRLTWHEWRTRGDVPQKKGYHTANLVGDKMIVFGGSDGHASFADVHVLNLQTLTWTLVNTEVKHNRLSHTATQVGSYLFVIGGHNGQTYAQDVLLFNLVTLAWEQKIPKGIPPPGRGYHVAVLHDGRIFISGGYNGVSVFDDLWALDLGAGAYLPQVTTFEVDENAEHLHPPAPPSKNGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYH2</accession>
    <name>K1VYH2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYH2"/>
    <dbReference type="FunCoup" id="K1VYH2">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYH2"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="InParanoid" id="K1VYH2"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="516" mass="55723" checksum="B02550AEBA44D735" modified="2012-11-28" version="1">MNVFADEATEERGENARLSSFVGAMALGDLVKSTLGPKSTSDGKVTVTNDGATILKSIQLDNPAAKILVNISKVQDDEVGDGTTSVCVLASELLREAEKLVTVSRIHPQTVVEGFRIASKAALEALKESSLDNSDDPMKFREDLFNIARTTLSSKVLAQDKDYFANLAVDAVLRLKGSTNLENIQIIKKAGGKLTDSYLDEGFILDKQIAVNSPKRIENAKILIANTSMDTDKVKIFGARVKVDGTGKLAELERAEREKMKAKVDAIADHGITCFVNRQLVYNYPEQLLADRGIMVIEHADFEGVERLALVTGGEIASTFDAADKLKIGRCDVIEEVMIGEDKLIKFSGVAAGEACTVVLRGATSQMVDEADRSLHDALSVLSQTVKESRVTLGGGCAEMLMSCAVENAARTVTGKKALAVEAFARALRQMPTILADNGGYDSSDLVSKLRAAHYEGNTEAGLDMDHGEVASMRELGITESYKLKRQVIVSASEAAEMILRVDNILRAAPRRREAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYS9</accession>
    <name>K1VYS9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000192">
        <property type="protein sequence ID" value="EKD04677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYS9"/>
    <dbReference type="FunCoup" id="K1VYS9">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYS9"/>
    <dbReference type="eggNOG" id="KOG2989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053603_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYS9"/>
    <dbReference type="OMA" id="NNDYQCE"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="35515" checksum="AE29AA91507F0E15" modified="2012-11-28" version="1">MSERKVLNKYFPPDFDPSKIKRRKRQGPKNSQITVTLKAPYTMRCTKCGEYIYHGRKFNARKETAEGEEYLGVKVFRFYIKCTLCSQEITFKTDPKNADFTPEHGATRTFDNWSEADPEGRAGALPTAAEDDEDDPEREARDAMAELERSQEASRREMEIMDELADLRSRNARVDTSKVGDDPEALLAKLHEERLSREEEERRKREAEEDDAEVAKYFTKMAPPPLPLGAGGKGKEKAREESPDEKDGSEEVDDKPKEAKGPTIKRAVTAAGEPSVASILAAKGKAAEPVAPPATAQVKRKREGMQKLLGIKKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYV7</accession>
    <name>K1VYV7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glyceraldehyde 3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYV7"/>
    <dbReference type="STRING" id="1220162.K1VYV7"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="InParanoid" id="K1VYV7"/>
    <dbReference type="OMA" id="QVKLYVW"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF134">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="12">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="41459" checksum="7B46C4EFEAEE08DC" modified="2012-11-28" version="1">MRGLQRANLQPAAHPTQRPRRCLAIETASVPTVGINGFGRIGRALFRLCLERDDLNLVAVNHTAASIEHLLTAIRHDSTHGPCHHARDISVAPADHPGMLKPTEINPNPSALLYKGRLIHLFSQRDPANLDWSSVGAEYIMESTGKMTTVEKAGAHINLAKGKKVIISAPSKDARNIVYGVNHADYAGDDVVSNASCTTNCLAPVALVLNRAFGVEAGMMTTIHASTASQKVLDGFSAKDIRSGRSAMGNIIPATTGAAQAVVRVLPELAGKFHGMSVRVPVTNVSLVDLTVRTTKPFGSKEQLVAAFKEAANTPVSEGGLKGVLGVSDEKLVSSDYLSSTESSIVDADACVTLNDNTAKVVAWYDNEMGFSSRMCDLAIYMHQRDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ52</accession>
    <name>K1VZ52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000301">
        <property type="protein sequence ID" value="EKD02048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ52"/>
    <dbReference type="STRING" id="1220162.K1VZ52"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_449901_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ52"/>
    <dbReference type="OMA" id="VCRPAIG"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="11">
        <location>
            <begin position="336"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="493" mass="54176" checksum="8CCE74703426BF74" modified="2012-11-28" version="1">MSRQDLLAVVKVKKLSDFRTIMDTIGEQGSQGCEICKPAIGSVLAGLHNEHVMLPKHHGNQDTNDKFMANIQRNGSFSVVPRMAGGEVKPEQLVAIGQIASDYGLYTKITGGQRIDMFGAKKPDLPDIWARLHKVGLESGQAYGKSLRTVKSCVGSTWCRFGVGDSVGLAIDLENRYRGVRAPHKFKGGVSGCVRECAEAQSKDFGLIATDKGWNRRAAYQSAEHLQRTAPWVESFDGGLAKLQRILIDDELGICADLEAEMASLVDSYEDEWKKAVQDPLVRSKFRQFVNTPERREAVEIVAERGQNRAADWPKEFPSQKFTLASLPPKSQWKWVPLAAVSDLAPNDENTTSAAVRYGKDSQLAIFHVPHKGYYATQQMCPHKRAFVLDHGIVGDKNGELYVSCPLHKRNFKLDNGDCINDADYSVLAFDVRPEGGKLLVRLPPEDELDMVIGASKWMVRKDTAKEMGGIAATAVGGCGGDNGGCGDPKLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZZ1</accession>
    <name>K1VZZ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZZ1"/>
    <dbReference type="HOGENOM" id="CLU_061637_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZZ1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42891" checksum="89CEE3915AE4B73A" modified="2012-11-28" version="1">MKNASPARVLDGLHFPHVLDAVLDLVPPATLAAVSQVCSQWRLHIKHMFYHLTVFEEERKPRVPIFRLSTGRTFQATTLLDQAAVLLYHCRILDSEPPKFARCINSSALLDHAFPSLQVSRVSDYWNDSRLLCGIRITHHAHPPTPGNACPCCHWSSDHSETYTFYGQGVGKFVLTTWGHDAMFDTRLPFKFQSMAIIFMFESAHPECPGDVEVFWETFSRAVIETWRIKRTVVVVNAESLNNRPLWLRDLSGCEVEEKLRLLALEGVYYEIMMGLSEFEEASQEPIDSANGDFDLEGSETDRELGTSDSVDVEATTEADAPDSAGLTRAEWDSSMRDLPPGPVCPVHFLSLEAYRALVGEHQFAIDTCRGWMREPVMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1G5</accession>
    <name>K1W1G5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">A1Q2_02782</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1G5"/>
    <dbReference type="STRING" id="1220162.K1W1G5"/>
    <dbReference type="eggNOG" id="KOG4686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030987_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1G5"/>
    <dbReference type="OMA" id="AYVIFER"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EKD02838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="482" mass="52828" checksum="3D89C5D28BB7ED4A" modified="2012-11-28" version="1">MATTQDRIAVLAHPHELAELERPRTHASVVDVVVSGDSDDAKDEKIDTLSVARSDIPHQVTDTPLHLRLIALSMILFFTTGAAFAESTLGPLKSTFVKELKINNAQFASISTASNLVNTVLPLIGGTVMDYYGSIYGSWLATVIALDLAWNSVTVVIARVSAVPMSKLGPNGGWYGWALWIPTIVCAACTLLVIAYVIFERRFVPPQYRPITGREVEQKRREAGLGKTTILQRMRTSVLNVLRLPVFYLMLAGTHLFQNSARTVYSANLTDIQERTRGTTALTGGYYSSLLNVIVIVVVPLLGIFFDKVGWRMPFVSIGAAIYVVAFALIGLTKVNAIAPILLASFGLSLNVLPWIASFPILVPDPTLIGTAYGLFSSLIACNNVILEVACGAIQDATPGQTYDRVIYLLIAIKAWQVLEGPVFDWLDGKMLGHTLRMSEKQRLHFDEECEETGRVLPGLKRCRPVTIIVACQMQTLELSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W479</accession>
    <name>K1W479_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000243">
        <property type="protein sequence ID" value="EKD03643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W479"/>
    <dbReference type="HOGENOM" id="CLU_2591484_0_0_1"/>
    <dbReference type="InParanoid" id="K1W479"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="80" mass="8682" checksum="FB9F0D920A78A82B" modified="2012-11-28" version="1">MLRTLNTTATRFARTYTTSAAHPPPAGQMTKPKRSLTYMASLLGLGFGGSYAALRMAFGRPPPPLMRAVPDHPRARRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W485</accession>
    <name>K1W485_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W485"/>
    <dbReference type="eggNOG" id="ENOG502S97N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015708_0_0_1"/>
    <dbReference type="InParanoid" id="K1W485"/>
    <dbReference type="OMA" id="IPHARVM"/>
    <dbReference type="OrthoDB" id="2564465at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852259" evidence="2">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="264" mass="28503" checksum="B3C58E3DEC13D275" modified="2012-11-28" version="1">MPYISTEALVGAALLVALAFGYQHITASGNDATSSAKKKKKNNKKKSKSAVPDDVAPIAVASGSETETKNNKSKKKNKGKQQATVKDPKSTPPATTPRSPAPEPVPDEPKSFAEAAQEDGSQEPKKPKMLAEKLLPKPRKTKVDDMLEPEDRAPQIARVMKIVHDTPASQKVSSFGDDYEDDSEGSSTKPQNDGWNVVAAKKKPVSLSIGGTPAPYKHSSDTSDGLTKLQRKNQKKAEAKKAAKAAEEADRLRRLAMHKKDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W503</accession>
    <name>K1W503_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W503"/>
    <dbReference type="STRING" id="1220162.K1W503"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129657_0_0_1"/>
    <dbReference type="InParanoid" id="K1W503"/>
    <dbReference type="OMA" id="WIGPNCK"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="131" mass="14610" checksum="0E4FA4A54C12B1B6" modified="2012-11-28" version="1">MADVKDPKIAEADVQSDKSDKLVLSETGTGDLAEFASKLDPTKASFGFVRVTYSNDDHSQRVKFAFVTWIGEQVKVMRRAKVSVHSSDVKNVIRSYSIEVSAESTDDLKEDDIVQRMRKAGGANYDRSKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W541</accession>
    <name>K1W541_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W541"/>
    <dbReference type="FunCoup" id="K1W541">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W541"/>
    <dbReference type="eggNOG" id="KOG2767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_1_0_1"/>
    <dbReference type="InParanoid" id="K1W541"/>
    <dbReference type="OMA" id="YRYKMEK"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd11561">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
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        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
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    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
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    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
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    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
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    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="200"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="362" mass="39173" checksum="E6CE9BE0F808A998" modified="2012-11-28" version="1">MPVLQTKIEGRGNGIKTVVPNMEDVARALNRPPSYPTKFFGTELGAQTTMANDRYIVNGAHQADRLRELLDSFIDKFVLCASCKNPETELVITGKGRNEDIHRDCKACGAHTGIDMRHKLTTFILNNRPKDGKKGGKKGMTAEANVGGPMVFDEKEGSDEGDAGMGSGAIGMDAIIGRGADPVLSNPDAICGKVKDLDLDDDEDDADSPYGQLGLWLEENRSASDADIIAKIKELEIVGKHKALIPIGAKLFTDKGVVTEISERASLLQALVTGEKHQKSLLGGIEKLVGLSDDVDDLIAQGAVSKILMALYQDDVLDEDVAKQWGTHVSKKFVPKDVSKKVRKNADAFLKWLDEADESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5T4</accession>
    <name>K1W5T4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_01426</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 9">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000228">
        <property type="protein sequence ID" value="EKD04283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5T4"/>
    <dbReference type="FunCoup" id="K1W5T4">
        <property type="interactions" value="929"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W5T4"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="InParanoid" id="K1W5T4"/>
    <dbReference type="OMA" id="TPSEHIH"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000011">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="16">
        <location>
            <begin position="10"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="17">
        <location>
            <begin position="336"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="18">
        <location>
            <begin position="481"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="568"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="228"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 13">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="128"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD04283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="651" mass="71510" checksum="0C9B0482478721E6" modified="2012-11-28" version="1">MGRLSHTEALLGPELFKKVRTTPILVVGAGGIGCELLKNLVLVGFSNIEILLTSQIDLDTIDLSNLNRQFLFRKPDISKSKALVAAATARHFNPSSGIEIHARHGNVKEASNDIEWISKFGLVMNALDNMDARRHVNKLCQAANVPLVESGTAGYLGQATPIVHVRCTLQRKADHQDKTECYDCVYKPAPKSFPVCTIRSTPSEPIHCIVWGKSYLFGKLFGEDDEAVDEAELDKAKEEGENAEEIENLKKEAAAFREVRRLLGEEDGPQRVFRKVFHDDINRLLAMEDMWKVPGRVKPVPLDYDGIMDGTFVAPPPRAPAQAAPAASTANGATTSAKLKDQKELSLKENLELFIDSCKRLSARAIANPDVILSFDKDDDDTLDFVLAVANLRATAYGIPTRTRFQVKEIAGNIIPAIATTNAVIAGMVVMQALQLLVRNESTVYKRHYLGPIPIKPIGNETAEGPNPNCSVCRDIYIPFKVDVNKCTLGEFVNEVVKKWLVPGLSGDDDELEASILEGGRILADPDFEDNFEKTLAELGLERNKMITVLDEDDKYRPIQFCILEPSDAQGNYSLPEQPPTIPERPPKAKEDAESEDEDDIAVLTAPPSKFPSPAPEGQTIKRKRSAAEGEEVPAKKTRTGAGAEDAIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W606</accession>
    <name>K1W606_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W606"/>
    <dbReference type="STRING" id="1220162.K1W606"/>
    <dbReference type="eggNOG" id="KOG2896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370137_0_0_1"/>
    <dbReference type="InParanoid" id="K1W606"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="752" mass="81013" checksum="BA1BD37C7DDF1381" modified="2012-11-28" version="1">MGGVGVHELTLEVPSPAKSSGFLSSPRARRASSISAHDRPVARARAPTLAGEGKHPHIQVGPAGSPEPEEVPARPLARCFITMTVPEATSNGDKNPPAHLSPGSPNLKRPAVTRSRTTSLPPMPEDRETRADQPKKEKKGGTASGSSSPARRPVAVRRSTMGLAPQSGRPAPVPFFFSPIHSPSTNPRFRNLDPEGDFAPWLTGTERAGTSVDIGVWVEERGRWRRLRGAGGLVDLTQLVPVPADTPLPPNTIELTLSTHPRMKFCLPPPGTEPPKRDLMKGVVERSLRETRMKKGANAGALHQLVSIQSAIAETQRQIAQLQGQIDALLQADADRSTLRRDMSELALKTKWVRDRVAEVDHSTEEARARNTLHRSRLSARRALLDAAIERTEITRGQASELANEIAEVEAKRTEILPAIHAKRAQHAQALDQLFPIEPVDAGTLIYSILGVPLPVPLGAKDPAPPLSLPPAQTPEGCPRIDERTTSAALGYAALLVQLISNLGGPAAGLAYPVTYGGSRSHVRDVVSVMQGPRSYEYAVFLLNKDIELLMHEWDLRMLDLRQTLPNLKNLLLMLSSPDAPAPGPVTGPGWASGAASRASSRRPSSLYPKSRSASLVWSPHPASRSASIASLVWQPSLDEKVARLSITDGNDKEHRDRIDAVRTDSLAGASVESVMSSASARDLSVSPASPGERRDDLTGQVLKSPEPEFNHDRIEEEEEGSEGTAEADGPSHPDEGEEHDEDDASSDRTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W677</accession>
    <name>K1W677_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W677"/>
    <dbReference type="STRING" id="1220162.K1W677"/>
    <dbReference type="eggNOG" id="KOG3997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405542_0_0_1"/>
    <dbReference type="InParanoid" id="K1W677"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="248"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="678" mass="75323" checksum="2092DB550E456C98" modified="2012-11-28" version="1">MGTAKTGKTRSRRAVKKANRRNKTASRSGSPAKSAAAAEASSPSQRSPLRRSPRRHLNNSDPVLMGYTRELQESSDDGFALPLTEGSWTVARTPQDSRNPTPALTEDQDDDTGVADDDVIPGTPTVELILDAEAGTTTGDQAVTVAAAPIKGFHLSSDGGVQTVMERYVDLLPLLGPPTADIGVQFFIGSPRRRVDDISTWKREEFQRLSEGHCLKHWTVHGNHTTNLASANPLGAFYEFDEQRKRYANVEAAVRRVATQINRLLKAVPTVKLALENMVHNNTGCGRDTHHWSLQELKRVIDLVGDSRAMLCIDICHAYITDYDFNMLDGVKAMNDFIDDVGTERIACIHVSNSSTRHGGTCEGHTHICNGQISIPAFRAVLRNPRILGKVPYYLETPYHRAGLRPRTDNTKYLKELRLKVLEWDLLEYLIIASEAEWEPTSWETQFQRFKGGARKLEKNIAYRATKAETQGEVRHANHLLKSRRALNARAVRVEKEEWLKTVKETCLTPANGAVVEDEHQRYTREIAQALVKPVKKETPPASTEVQVSEPQTAGKTVRTMKQRSTSASLMLADAAGRIVDTRPRRAAAAQSAGTFANGGESSVWASFDDYELPQDVDPPEHEEHPLYVPNAYVKRTLKRTISVDESTTAWRAEARQGSAGVPSAPPPQRRRRRSDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6H4</accession>
    <name>K1W6H4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6H4"/>
    <dbReference type="FunCoup" id="K1W6H4">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6H4"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004825_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6H4"/>
    <dbReference type="OMA" id="VTWPAFV"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="532"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="908" mass="102682" checksum="42C316FD83523A6B" modified="2012-11-28" version="1">MFFPIFLLTTNQRIVHPYLFTDQFFTFLFAYGIATVCGIIFAEHSSFPALASHFMKAVDTTCQLLPTSLDTILHSEIGTDASSSASPRDEEAGVQGVPGMVDPSARVKQQELAKRLRSQIKGIQQTHKDYSLDIVHARHHPKALIPVIRLLSRLQRNPLLGPTGHVPGDRIRAALERTYASPLFHRSTNHSPMGRTPRRSLSRHSLTSAVESAVIVASPSQLSLELNRLTEIRGGTRSLNGSIRGSIRTEIIRPDSPGRDSARFRLKQACLSLTDTITAALYGTGNLVAIACDWQGDQAPKDAVHVPELKAQLDRALLDLQKRLGGIVDTIYGADGLARTTSDSHLSARAITFEDELIETDWLDDEDRFRIAFYMIALLDLAKDTRELLDKAEELEQTSGKKRWYFPPILWPWSPVAPHAEMPSIERVSVPPQDDAQDAPREEDLDYVHKLLHEKRELHLHAREGSLTQRIANAWRLIWDRHAVVMARVWLSKLFYGIKHSRHVHFAVKQTVGICLLSIPGLMPPGQAGRVWYDRSRGPWMVVSFMYVIEVTTGATLRIGFYRMCGTFLGCVTGYVCVLIAHKNPYGLVTLGTFFAVPISYGVCFTHFAPMMIVFAITLAPLLFMEYLNLDEGQGIFELSWMRFVDIIIGIAAAILLGSWLWPIHARVQYFSAVGDTMENITDYYLRMSRDLLRPTPVYNANSKQYRVLERRARANIARCRTLQTVQQREIGLLPRPTRLYGEIVDLLERLIETFSEIRTLRFSLPRKATVLDVLPIRRELVSSILVNLWACGQAFRSRSPLPQVFPSPRNPLSEVMETTDDYAREVRQMRAREKHRRMRDSTDDREDSGAGQQAYHAELGVLYAMAENEALTEAINCIDESFLDMDVNPHDVKGENSAHSSAEWWHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W739</accession>
    <name>K1W739_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000192">
        <property type="protein sequence ID" value="EKD04688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W739"/>
    <dbReference type="STRING" id="1220162.K1W739"/>
    <dbReference type="eggNOG" id="ENOG502S0NE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376426_0_0_1"/>
    <dbReference type="InParanoid" id="K1W739"/>
    <dbReference type="OMA" id="RMNTERP"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="201"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="669" mass="71063" checksum="9313CC8EF2413929" modified="2012-11-28" version="1">MGDNTRYGNPSEFDIDLHSIYAAYLGDFDAQNIDWWDASWGGYFRSFNDFLGFGWEAMVIVDLHTGRAHIAARAEQIALFGETLDREPPSLLPLTPAPARNRTLHRVVNIHDIAGYKKLSTTMAPAELSHLRARVRAGEPGVIGALFHAGSPDPDAYAATAGVRTNGQGYTWACLRTTWWDRGGPPQGYVPGHGRTVMAKPGQGGKALILELGLAALRCANLRAVRMNTERPNYPRAFGFGRSAFVSEKSVERIVDASLGALASHDSEGGANTLVLLSVGEPQPIPLPATTTLQQNILQLDVLQLEFALLQQAQRQGVPGVGDRRQPLGSLRQLLHHLQIPVAPHAPLGNAGNEAFYTVLAFQKLLMRDTRLPDQLFQQPAFAQPTDYFVPPAMPAFAPAPYSPFNSPGAGLPMPPPIRDGSRRGSSSSLNRFSLPPIDLEPPSFPAPMSRQNTGDRAPRPTTIADEMSSPGGSRQPGRGSANGNGSAASPTTGIPRSQTVYWDEAKYSEGGKRPPSAAARANGTSLSGSRGPNPPSSLRHSALFPGNMAGSRSVSFHDAHGNGPNGAHSGGASTIRSQESANGSGSFSRTNSGSMLQQHTRGSSVSGNSGSGSASASSGSGATSEASLTKPQNQEEPDRTSNERAVRKMKSEKSVKHLAGALAKFWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7H3</accession>
    <name>K1W7H3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000188">
        <property type="protein sequence ID" value="EKD04838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7H3"/>
    <dbReference type="STRING" id="1220162.K1W7H3"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="K1W7H3"/>
    <dbReference type="OMA" id="WTSIVYE"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF1">
        <property type="entry name" value="AMMONIUM TRANSPORTER AMTB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="44"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="561" mass="61078" checksum="95E928CC233CE77C" modified="2012-11-28" version="1">MVNVTYGILTPNADGTYSFDKLGTDIVATTKDGETAIYSAGDIAWVLTCTVLIIFMIPGLGYLYSGLARRKNALQLLFLSMASLAVVSFQWFFIGFSLVFSETGGSFFGDGRHVGMRGVLEEPTPESGGRLPRIVLATYQLMFACLVPAVLLGAAAERSRTLPALLFIFCWTTLVYDFLAHWIWSSNGWAAKWGVLDYAGGVPVEIASGVGGLAYSYFIGKRRGYGTERVLFKPSNVSSVTLGTVLLWFGWMGFNGGSCYAANLKAAMSIFCTNLAGSVGAITWMIMDFRLEHKWSMVGFCTGAIAGLVAITPAAGFVGAPAAALIGLVSAVVSNLATRLKSTMRVDDPMDIFAVHALAGVVGCLMTGIFAQSSVAANDGFTEIPGGWLNGHWIQLGKQVAWVAVGAGWTFVVTIAIMFVINLIPGCKFRASEEAQIIGMDEADHDEYIADYAFFRRDLEEPDMRMWRTFTPQFNQTPAPYRRSMSQEDVERGRGLSPHPRHDRSRSRTRTGDIEPMEPINEAHGEGQVRFQQEKLEGTPTSSTATSLDKPIDEKDVADRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7I8</accession>
    <name>K1W7I8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7I8"/>
    <dbReference type="HOGENOM" id="CLU_2063129_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7I8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852675" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="119" mass="13315" checksum="6C571AA0BD6252E6" modified="2012-11-28" version="1">MLTNFRFFAALCLFLGLQALAFRITSPARDAQWKTGNRETVSWEDGPSGKLIFQLQVVNKAQFIYYDIFSGDFGAGNGQFAYKPTTKDAQTAEWAGTYLRVIDGSGKELAVSERFDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8F0</accession>
    <name>K1W8F0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8F0"/>
    <dbReference type="FunCoup" id="K1W8F0">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8F0"/>
    <dbReference type="eggNOG" id="KOG3298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="InParanoid" id="K1W8F0"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="171" mass="19013" checksum="28E3DA1051F1C635" modified="2012-11-28" version="1">MFFIRELTHTILLHPSYFGAQLEDYLKQKLYEDVEGTCSGKHGYIISVVNVTDIGEGKIMPSTGQARFKCSYTAIVMKPFKGEVVDGKVSNVNKMGFFAHVGPLQVFVSSHLVHADMKFDPNASPPCYRSADETIQAGSRVRMEIVGCRIEANDIFAIGTIKKDYLGQIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8U6</accession>
    <name>K1W8U6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00453</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8U6"/>
    <dbReference type="FunCoup" id="K1W8U6">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8U6"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_850427_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8U6"/>
    <dbReference type="OMA" id="FERWQYW"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="227"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="327" mass="37339" checksum="AD0BB3C98F1C1B0D" modified="2012-11-28" version="1">MADVKPNIKPTVTADGHEVFDIPVEEEELEVANSMGQSKIWAMKVPRFLLERWERVNVGGVHLGTLTQPPKITLKLPIQEEGSEEPPNKRARLNVEGIPDEYEVVMPSERAKNTYVFTEHERTWVAAPGEESSSAKRKREKVGRRTRPRGFCPPDPEREVPQDPSAASSRERELETANRPARRQEHVPGQAQSACLRFLQRVEYARQGHGSDMQLGAARVAPGERFARLERNELIDRLFALFTEKPYWSITALKQTLKQPDAWLREVLKDVASLIKEGQYANMWELKENWKDVNVGGADSKAKLEKMEAEEEEEEDDDEDDFEVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9N4</accession>
    <name>K1W9N4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9N4"/>
    <dbReference type="HOGENOM" id="CLU_1662047_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9N4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="16938" checksum="0F462C8E12330C50" modified="2012-11-28" version="1">MKPDLGDRGGKPPSSSSRSLAAHAAQDKPVETRDATSDVGPARPFCSVLAAALLLSSGFLWEQVRSGATTGVEPVELANRTQLTMNVHNVHPPGRSPGDRAPGLRHMLSNCRPRRYLKPDLDPASVNSVLARLCLAVSGCVWPACARTDTGLVTYNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9V7</accession>
    <name>K1W9V7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000089">
        <property type="protein sequence ID" value="EKD05558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9V7"/>
    <dbReference type="HOGENOM" id="CLU_2074787_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9V7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="118" mass="12902" checksum="FEF65A61048CD0B6" modified="2012-11-28" version="1">MSSDYTATAQAIRENQARRNSNSSMPLFNKTANPMSPDITNDRRQSWDWAEAHAPSYNTAKQAALAPGAAAMTQQPPPTAAPAPSAPTQQPQQQQRRPSWVARHLSMGDEDARRAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA00</accession>
    <name>K1WA00_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA00"/>
    <dbReference type="HOGENOM" id="CLU_1732777_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA00"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="151" mass="15407" checksum="252A691138D07850" modified="2012-11-28" version="1">MQRAASLVSGCATGVVVPSAQVVPLTQVVPSTQVVPSTLVVPSTPVVPSTQFVFPPGGHALAHDPDPKIWSGRARDPGRARNPGRARDPGRALDPAILAHDPDIKLIVMQTAASLVSGCATGDRAAALVPIPVKIATEIASETATDIASTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA69</accession>
    <name>K1WA69_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000043">
        <property type="protein sequence ID" value="EKD05648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA69"/>
    <dbReference type="HOGENOM" id="CLU_1289756_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA69"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="214" mass="23702" checksum="0C4E0DE3905D3C8C" modified="2012-11-28" version="1">MSSGEHPLRCFNVHHTECARTPNPTHSAAVVIVPSLFPTSFYSALHPNLMATTLNAQMRWHSRACAALSSSWHSADETWPEGHSQRGPVLELASKSKTWPSCCGVHCGEHSWRNLVHKTSTSVDLNEASDNLPVSLGDDKVVKRCRAPTYSAEVVHEKLSPLFSLERDATDGRRQQMVQLEEEVLGVGITLSVVDNRAVHVIRPDIKRRGLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD01</accession>
    <name>K1WD01_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD01"/>
    <dbReference type="FunCoup" id="K1WD01">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WD01"/>
    <dbReference type="eggNOG" id="KOG0269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007954_0_0_1"/>
    <dbReference type="InParanoid" id="K1WD01"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115004" checksum="DE25035CDF91BED4" modified="2012-11-28" version="1">MNRIATVLYPARDVSPARSSPFPPGPSGPPFPLSINVPNATKSIYDDPRAIRFPSPPPVLLHADSSTPQASPGGTLALPKNGRTSRSASASRSHRNSINSSSNSNEAGSSSFASRTSASRTSSPAPAPIPDRSLRVNLMQAAQPKPSHKSRAGTPAPTGSGRLTSMAKGPPSRFAIDLRVLQITDPEGSIPLAAQATPRKVSGRQPGAPFARGPGGSTVSEVVNLWKGSWSIGKGVNAVDWATGNYDSKVLTATPSGSFLIFDVNRGKLEREVSSGTPRPMNAIKTCKSSAQGHLILTGGTEGQARLWDLRDPDPVSRKYYKHNAPVTALEFCPDDHHQFVVGTEAGGLFRYDYRVPAKAIGKVWGAHGSRAVHDLKWKIGGEDWDQTGQGWMASAGADRTVQIWDMALPWEKGSTPVHTLHTAYPIRYVDWRPVHPTELLVVPFDQTSNPAYDANKPEPSEPVVMDQGEAALEVWDVRRHYISKFALSGCDDIPVAAIWDDEDSLVACYQKGTMIQIDLQSRVVPKTLSLETIPRQVVSWSGKGELAYAIDRFKMGEIPFDDVKPEFASHWQIGHGGTRGKSIADPGYEPAQTTGVLPLPDADDAEFEYMANHYKLEGDSPLQLCRWNREVASLCGRTDEAQAWDLLHGLIDEFAPVKALFNEGIFSQPTDGFTPAQPTSPTGAPDRNHSPDYEAGIPIAPAEEDIVARENRSEESMSSRSSFEEDDASVAPQPKARFLSFNPPEIETVRPSAIRNVSSMVRGGSSGGGSRNPLQKRLTIETPRDDTPTPVADMDYPDPYGIAAALDAWSSGLGSVEPLGRGRITSRSTPHSTRPPSPTRLAKAGGSKPPSNLGSQRPSIDQTKERIQPGQLTRLSHSAYTPEQWDNYRTQRCAGLLDWWQAFITDGEVQVATALFVVGGTVIDFPRKQTLRVLESYLVPMAYLRRFAGLVETQTVGAIEGITQIQYCMKCGKSTGSLEDAPGSRPFWCGHVMVARGADSSREPVRGLWMSCRKCKHGGHQRCMRLYYTDISGDREASTRSAIDAAHGVTNAISQPAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD27</accession>
    <name>K1WD27_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD27"/>
    <dbReference type="HOGENOM" id="CLU_339533_0_0_1"/>
    <dbReference type="InParanoid" id="K1WD27"/>
    <dbReference type="OMA" id="RECETQA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="837" mass="92025" checksum="11A6B0E65078D7F9" modified="2012-11-28" version="1">MPCSPELGEMRDLPDSPTPNLRSQRSRSGATNVPQPPPKLPSGKIGSTHVVKVPSMPPLPRKPFSEPDIFSSFKSNVKRNAQSKLGLGAPRTRTKLYMSPPPRNKSGGLMRRLSEELVRRSHNDTADDSITSEESFGDDQSFDYSNESRPWEGLYPGVVEQMRIDVAILDELETDELAHLIFVMADKIKSEEQAGKSKAARIVQLERQLGKTALTPDAVPVITVLDEDSREVPPDVTETFSDTPSYLDEDSELPQLRSQLLVRDTQIGILERSVEERDAQIDKLEAQLRECETQACAWAEKGSKQQLALVEKERDIANLQVAVEEHRAAATEARKQLKAKEAVYARLSAEVEERERLNLALQSEVEAAEAEIAALQADVVEREARIARLELEAEEREAELADVTLALEELEEEGRYADAAESIDGDGHELQHRVSTRELLEGMEALRLANDEAAADLGSVRSQLRDALKNAAEYKARAAEAEDEADKARSAADRAEATLRKTRTLVAESHRQAHEAIHRAQTTPPSPPSSGSATSSALSEARSAVAESLAAELATAQAYSATLESRLSELQLSLESAKLDSSKFERLYEAHSAESTATSKEMLALKDEMEKLRTASADADMKVFSLEKTIHDLELKIEEMTVLISSYEIERQLMTPKGTPRGTPRGTPAGTPHRAGTPHRAGTPSLRQLATTPKTARSLRKELSETRSETPTPTPSKTRVRKLATPVALPKREPSIARTSSVREGVVRNSSLKEPSVTRSASMRDSGISPLRASTRANVSTTSTDSTESEKEKKGEEKKERRSSKIYAQAAANGSKLPRGRYSVIRPCRVMSSEDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDP3</accession>
    <name>K1WDP3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000365">
        <property type="protein sequence ID" value="EKC99718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDP3"/>
    <dbReference type="STRING" id="1220162.K1WDP3"/>
    <dbReference type="eggNOG" id="KOG0360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_0_1"/>
    <dbReference type="InParanoid" id="K1WDP3"/>
    <dbReference type="OMA" id="WMALACK"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="349" mass="37759" checksum="54273E8355BFF1BD" modified="2012-11-28" version="1">MAASMYQRDPRAGLFLGGSRVSGSEVRDQNVTACQTVGNILKSSLGPVGLDKMLVDNVGDVTITNDGATILSLLEVQHPAARTLVELAAQQDKEVGDGTTSVVLLAAELLRRANDLVRNKIHPTTVIAGYRLACKEACRFMVDHLSTKVDKLGREALINVAKTSMSSKILSADDDFFAPLAVDAMLAVKTVNPKGQKKYPVKAVNVLKAHGKSARESFMVNGYALNCTVASQAMKTRIQNAKIACLDMNLAKQRMHLGVHITIDDPDQLEAIRARESEITLERVRKILASGANVILTTKGIDDLVLKEFVEAGAMAVRPPLRALRIDCSPQRQTTNMFVLKGSSMNDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGT3</accession>
    <name>K1WGT3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000337">
        <property type="protein sequence ID" value="EKD00634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGT3"/>
    <dbReference type="STRING" id="1220162.K1WGT3"/>
    <dbReference type="eggNOG" id="ENOG502S3WR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422840_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGT3"/>
    <dbReference type="OMA" id="MYDACTG"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="281"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="486"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="648" mass="67368" checksum="5B8C06183FA22128" modified="2012-11-28" version="1">MADAESFLLLTLPGATVTQDFQGDQMVLAKGELAIDCVSLPIPPEIGHQTANPFSNTEPNPTHDLWLVLKVGHDFENTLVPENFLIPRAPQRAGEGPSYTVRSPDIPGASLTLSLQPPHSLGEAEDLQTFETLLQQYGALKQGESALTGVHLPMLVNKGEDQKAHPAPVGGPSTGAAVAGGAAAGAAGAAGSGAYGQYDEKHPPPPAQLEGDATNDLKGKLVLVDQDSGSVMGELDAPTVAHDVHNQDPHAPVFVDFDMAEKYVGHPVEVTRIPPEELNDSTILWTADKLSRGILWFGDAGASALRSGAGAFVKRTLPRPEPMHFSDTTRKNLDRTYRTTAGASRVTRSTLNSVHNVIAHLVSKKDAKDAGVPAESTGQRLRAEAGSAYNTLMDVGGPALNKLKAKAGYGSSSGYSSPATGAEGKPPLPTSEKPPLPTSEKPPLPPRTGEEPPAYGTTGASGAYAYDRKDATGTPGAYGQQQAYIQTSQPGSGATTPSGKKRPLLNRSLLAVDSVLSSLEAATNQLISSGTSAASQMATHRYGAEAGEAVAQVGGSARNAVLVYVDVRGMGRRAILKSTAKGYVKARLRSGEKVELQGPGQNQQSQAQVASQQTIGGAGPSQAQGAGGNGLYGHGKQDIVVDVPQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIQ7</accession>
    <name>K1WIQ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIQ7"/>
    <dbReference type="HOGENOM" id="CLU_847828_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIQ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="329" mass="36619" checksum="3A64353AFF82A325" modified="2012-11-28" version="1">MSEEPRFANVYGHVPATTIEYLKSAFNYLPYALALPFVPAGLYTVARALYDFHSTHKILYTFVGTHRARLCSGYPIGLLRIEGPLTKILAGVGAPPELLLMEEGEQTNMGAHYSPQLFLGLHIWARKMMVELHAARKENRPPRCMLYTGEIMDVQEWLQCPPALPYCMLPDAYQELGPVLQDRTFKNLGQLIDAINEAKIDMGTGVVWSGERRFGARTERRFGIHWADVLVGNIKVEHAGCVPSSVKAVHNPDPSLDFLMKEHLAREETEDEGKQELGGNAAAALEMEHQNGGGTRGAHVPQDKFDVRKAQVGTGTAGECWCRKLKLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMP2</accession>
    <name>K1WMP2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMP2"/>
    <dbReference type="HOGENOM" id="CLU_061637_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMP2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35426" checksum="EC8ADF8EA9B991A9" modified="2012-11-28" version="1">MSAQRVLTESNFPHILHAVIDISEPITVFRVGQVCQHWRRVVKDRFYHLKAHYTARFGNVECVLRPRASPSIMFAVQRANEDKLYQMRHCRVLDFEDKAGNALLSSSILPAGEIHPWLVFAQVHTVRLFCWAKVSYFSINIPRVVVPQGHRLESTPVSPRRRSKVVTLLQGCWPEDTYNLLWREAVGSLVLLFRPYDTAPIAPTPSSGSVDASPLLDIPEGLKYLLSILCTAHFTHVKVIVVNAESVYLPPSHRGTGQTVRDLLERCKATTDFATRLRLTNAPFSFLTLEEYRSSIGEHEFAIETERGYVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WND0</accession>
    <name>K1WND0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyoxal oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WND0"/>
    <dbReference type="STRING" id="1220162.K1WND0"/>
    <dbReference type="eggNOG" id="ENOG502QPS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009630_3_0_1"/>
    <dbReference type="InParanoid" id="K1WND0"/>
    <dbReference type="OMA" id="NKPNPGQ"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854860" description="Glyoxal oxidase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="71"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="466"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="71334" checksum="EF4AC7F7DA95C0C1" modified="2012-11-28" version="1">MYATALQALWTVVPLLAATANAATPLSFEPAGDAGISAQMMFLGTKNKVYILDKSENNPTTIDGKYGTHPAWAVEYDIKTQQVRTMDVYSNTFCAGGAVLGNGTWAVFGGNQPVTTNGVATNEPAQYKNLAGGTAIRLLDPCDDESCQYVQGEQTYDISKDTGGYLQMTGKRWYPTVETLPDGTLIVIGGDKNGGYVNTAAQDNPTYEFFPPNDEGAVNLQFLTDTLPVNLYALTWLLPSGKLFMQAARKTIIYDYKTKEVTWLPDMPHATRVYPASAATAMLPLTPRNNYNPTLLFCGGSSTDKWGDDGGPHYNVTAVPADNTCVRITPEGTSNPQYEDDDYQMEGRSMGQFVMLPDGTMWHGNGVAMGTAGYGWDKYSIGQSFGQDPIYVPTIYNPDAPAGSRWNRTGLQSSPNERMYHSTAILLPDSSVLIAGSNPNADFTNEQWRSRTDLELWYPWYFNEQRPSSAGLPKTFSYGGEGFNLTLTDIWVTSEEKVKTAKVVLIRGGFNTHAIGFGQRMLELNSTYIMDQSQDNKTTLCVSQLPGDVGPMVFQPGPALAFVVVDGIPSHGEMVMVGNGQLGEQPTKPNAPLPASTVIPKPEPPKPTEDQQQNAAASEPSTTSDSKASAPSDARKSGALPLVSGITTALFGLLLAPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP91</accession>
    <name>K1WP91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP91"/>
    <dbReference type="FunCoup" id="K1WP91">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WP91"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="InParanoid" id="K1WP91"/>
    <dbReference type="OMA" id="NMWAVFT"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="59539" checksum="DDF64C43BFBE8038" modified="2012-11-28" version="1">MMPTHNDKSGASPTAVHQRSQPHKANIIDFTITVPGCERKSTDEPPKPRWWTPEFYFYYLIFLIVVPIMIYIPIRLSSSLGYLVPSHLLRRLGYTSAPARAIFISVFAVGMLFGLHGWSVLKILAILAVNYFAAKAKKPATLEKLWPGVVICVNMGLLLLSRKFDGYRFSLLHDSLGALDSMDGMLSWEVSFNFSVLRIISFALDYHWRAVPPTTAPTEYRDRVKASHPEEEYNFLYYIAYILYPPTYIAGPIMTFNDFMWQLRHPVEITPRERVSYLVRFAGCMLTLESILHTMYVTAMQKTQAWQGASAADLSMIGFWNLVIVWLKLLIPWRFFRLWALLDGVDPPENMVRCVANNYSTLGFWRSWHRSYNLWTVRYIYVPLGGAKRVFLSTVLVFTFVALWHDLSWQLLAWGWLVAGFVVPELVGRALVPASKYGQKWWYRHVAAFGGALNVLLMMTANLVGFVLGLDGVKYLISMLLGTGSGILTLLFNIACLFIAVQVMFEYREEEARKGIDRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQ42</accession>
    <name>K1WQ42_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQ42"/>
    <dbReference type="HOGENOM" id="CLU_960389_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQ42"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33611" checksum="26462B72D5F3D392" modified="2012-11-28" version="1">MLQHLNVMIDHAYYPHIIDLIFDFAEFDALLAMSRTCREWRDRSRGKIDHVYQFDGMYMCYPFPINRTKALHYCRTLDVAMNPLDEFDSLEDGLELVRRAAPNLDTVRFVDIGCLKMPVWVVPTRRLVYGRFDPNPDLYGFGEPEDDEPCASSVKKVVINHTSDRASCHHFKAEDFSVPTDEVVFIFHGKETCPCCFMAVIRATQIGSVPLTVVGIESLSKQTTIQPYNVRKQKLTRSVGGHRQAKRGVTALTHMEYRQLVGEKEYAMDTNFEKPRQLFRYEAPSFYDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQM7</accession>
    <name>K1WQM7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQM7"/>
    <dbReference type="FunCoup" id="K1WQM7">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQM7"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="K1WQM7"/>
    <dbReference type="OMA" id="AWRTYYV"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63812" checksum="4DCB0F9458237D39" modified="2012-11-28" version="1">MSALRSMGQLHASVAIDVRPPYNPDVNGASPGIACLSRSAPLSPPVESSATMTEKFEKVDELRLEPVDSKHSHPKDNGGISIHDPAANDAEQLVHDHDEFTPQEYKKLMLKVDLILMPMLMIIYGLQFSDKTSLSSGVVFGLREDTHLKGNEFGNLSSFFYMSYAVAQYPMAWVLQKVPLGRGLAVCVIIWGVVVLCLGVCNNYAQLAGVRTLLGWFEAVVTPGFAIFTSTWWLRREQSLRQGLYYSMNTFFAMVFGVGIYYIGKNAQENGGLSGWRVINFFLGGVTIGMGVLFFIFGGTPDEVWWLSKREKRMAKARIVENATGSTQHPWKWHQVRECFRDPQYWFAMLFALAGNIPNGAITVFNTLVYKGFGFNDLDSILYQLPGYAVTFVIVVASAVGVRYYPKLRFPLAILYQGITAFVLLFVGLAEVGRWARWGVWLLCLVYSIATFITAWPMISMNVAGRTKKSFFGGSSLIVYCIGNVIGSQIFLPSDAPKYHRGLIGCAICLIASIFITGGWWWYYVRTNRKRAQFFASQGISEEERRFRAQVNGELDLTDLENKEFEYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQN0</accession>
    <name>K1WQN0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQN0"/>
    <dbReference type="FunCoup" id="K1WQN0">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQN0"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQN0"/>
    <dbReference type="OMA" id="ENRFRFP"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="369" mass="40167" checksum="2A13EF5E8FA0FC48" modified="2012-11-28" version="1">MAPALFTPTKLGAYTLKHRVVLAPLTRNRADPKTLVPSDMAIEYYKQRASDGGLLITEGAFISAEAGGIAGAPGIFSDEQVAKWREIADAVHAKGGRIFIQIWALGRTANPALVPVVYGPSGEPYVANPKKPVPVPVKEMTEEDIDRFVANYAKAAKNAIAAGCDGVEIHGANGYIVDQFLQSVSNKRTDSYGGDINGRTKFPLRVLDAVCAAIGPERVGIRMSPFGIVQGMREKVPLDTFLPYAKLIVKHQPKLAYVHAVTPRTYGTTDMPENMVVKDDDLEPIRRVVRDAGIAFISAGGYRPEGALKAAEDTGDLIGMGRYFISNPDLPARIAHEWDLTNYDRKTFYTNGAHGYIDYPTYRGETAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSW0</accession>
    <name>K1WSW0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000235">
        <property type="protein sequence ID" value="EKD04059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSW0"/>
    <dbReference type="FunCoup" id="K1WSW0">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSW0"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="InParanoid" id="K1WSW0"/>
    <dbReference type="OMA" id="GYDSAMN"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="14"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="384" mass="44107" checksum="E9FEA4745D9861D9" modified="2012-11-28" version="1">MAYRASRGRKQAKKGVQLTIMVVGASGTGRTTFVNTLVEQPMLPHRAQQILKDPENPRSEVDPSLAEQAAADAHVERQIQIKPVNVELEEDGVRIALTVVDTPGFGEGIDNEHCFQEIATYLERQYDDILAEESRIKRNPRFRDNRIHALLYFIQPTGHALREMDIELMRRLSPRVNVIPVIGKADSLTPSELKAFKRRIMEDIEYYGIPVYNFPYDPEEDDEETIADNRELRSLLPFAIVGAEEEIMINGEAVRGRRYPWGIVEVDNPEHSDFGRLRSALFQSHLTDLKEITHDFLYENYRTEKLSRSVGGDADTTALLPEDMANQSVRLKEEQLRREEEKLREIELKVQREIQIKRQELLAKEDSLKVLEARLAAQGSNQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTI8</accession>
    <name>K1WTI8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000232">
        <property type="protein sequence ID" value="EKD04194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTI8"/>
    <dbReference type="eggNOG" id="ENOG502RBE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2672864_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTI8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="75" mass="7546" checksum="D33EC59C7D6A072F" modified="2012-11-28" version="1">MSAPQQMYQASDGKWYPVSSMPQGHQQSYGGGYGGGGYGQQGGMQYGQQQQPIYVQQGHSGGGGAGAGGAGCLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU49</accession>
    <name>K1WU49_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU49"/>
    <dbReference type="STRING" id="1220162.K1WU49"/>
    <dbReference type="eggNOG" id="ENOG502S0ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541000_0_0_1"/>
    <dbReference type="InParanoid" id="K1WU49"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="54134" checksum="43F3BB1798E4AFD9" modified="2012-11-28" version="1">MYSWTLRARGGSERSELATRARVELQAEPVGASTDHDETEPVEVEGQPARVKSQEWRPICDAAITGSAFKTRSHELPRRAWIRRSVESIRRAHRLGLRWRAEIRSGVEVFHRGGTTSELFQRQDIQGSGDGRWAVPARAGGNGRCGILPAESGSPLCRLCRSRPYCQLPPSNRTDHRHNIYAAKDARTQMENTSIMTLPSSYGATDTRPSSDSSKSKPTEPTEPTEPTEPVLPTIHPSLGHDISNGTNGSGQASRKDRGQAIKAWLAKSVDSKQASLISVANCFLTGFTSAVAFSACYIWPGFQTGNVAQLAISLARVFDPAPIRTHGFQKGDQQALVSLVCFWLGASLGRIGARLGPKARRWILPATFCQVVLTVVAAVLVIPEPDYGSRPNPSWADARGMAALGCLSAGLGIQGIIGKRVGSEMNTTVVLTATWVEIFNEPGLFTFGFVKSRDARIAGVLMIFVGAFVGRALLGVIGSQGALGVLAGLRALSALGWAMVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVJ1</accession>
    <name>K1WVJ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diphthine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVJ1"/>
    <dbReference type="FunCoup" id="K1WVJ1">
        <property type="interactions" value="524"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WVJ1"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_1_1_1"/>
    <dbReference type="InParanoid" id="K1WVJ1"/>
    <dbReference type="OMA" id="KECINAE"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="199" mass="22631" checksum="052FDACE0CCC9F3E" modified="2012-11-28" version="1">MTALGSTGLQMYNFGQSVSLPFYTETWTPDSWYDRLEENVRYGMHTLVLLDIKVREQSEENMARGRLIYEPPRFMNPAQAFSQILLTENKRTNPPPPEDSDDEAVAPGDKFLKPEETLAMSLSRIGTPSQRIIAGTLKELSELTEDDYGAPLHSVVIVGKRIHPLELEFAGRWCVGGENGQWWKVAKDVYGVERETFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V002</accession>
    <name>K1V002_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V002"/>
    <dbReference type="HOGENOM" id="CLU_2238501_0_0_1"/>
    <dbReference type="InParanoid" id="K1V002"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853485" description="Invertebrate defensins family profile domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="10686" checksum="C99AF1AD5C9C9BF1" modified="2012-11-28" version="1">MRFVIISAALIALVSAAPAPTPAGDAVNVVMLYGRDWQGGPTIDCSHARAVACAESCRKLGYAYHQCIIGSYAGCYCRPGPPGGNGGGSAGTWKRSIETGAARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1I0</accession>
    <name>K1V1I0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1I0"/>
    <dbReference type="HOGENOM" id="CLU_630360_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1I0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853872" evidence="2">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="435" mass="47764" checksum="D84893E0B623418B" modified="2012-11-28" version="1">MINVVGTLFLILLFTSGNVERSVCRHTTSTESGARKRSSNRRSYKTQKLARSFGILGRLPQPISWLADRVLGWFPFYQSIKTLAVLACAYWRLELVAVPLLKRHERQIDLTLSLLYVTFGVLYHLAVELPRALIRRFLRSWSLWLLPCDDGGSSDVSDTQCSSREKRQQEAPPATSKTTSKRARRRVSPSSNASQLPQWPPTKRSVFSGDSSTTRKPSLGLPRSRSSKPTASVALPPITQPTKEPATERRPVSGTSRVISGGERHRGREDRVTARRGPTQGNAIASTAAKLKSLPRPPSGDLNHSSGSTSSGSTSSPTDLRPSKQAASKAKAHQDHADVLPQKRSRNVNEDERSPSPERHTTRQRRLASRETGNGVKRLTVKERATLATASTVKAKSASSTAAGKRRRTADPEGEAALPKRVRSTRSTTAKRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V296</accession>
    <name>K1V296_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V296"/>
    <dbReference type="STRING" id="1220162.K1V296"/>
    <dbReference type="eggNOG" id="KOG2306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_662550_0_0_1"/>
    <dbReference type="InParanoid" id="K1V296"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="415" mass="46323" checksum="0EF8F7DF8C1C857C" modified="2012-11-28" version="1">MSAAPHANTNFELHMKAVAIGKCDPEIRAPKALTLPFTAQCYDLGERQSPWVGDVDIERHFFEKYAAAQSCPSPSPSGYSPSTDFNSELPPSYPGYRVPPVGQLQLLIKTPKAAVKAFIVSYDLTAVPVGGRLLARERTYVSRPSSTSPDAPRAESLRFAVQLQFVCTRQDRKRQYHLSRSVKLVFAAGPGWDEGEQRVERHDEVVPPERRRRRESSPEAVRRRSLLASSPAERRRSFASSFASSPIDSPPRRRSIYAQSPEATSLGSPRQSLGQTIESWAAIRTEWEHRREVEQAEKAERERKEKEDPRPRLRRMPTRLEGFQPPPARPTSPTPPRAQPSLLSALRAASPVPPSPITMSSTAPPASPAEPQTPRRTRLELAEIERGATPPLSPRRRTSAVDRELSELLRSTTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2E9</accession>
    <name>K1V2E9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2E9"/>
    <dbReference type="FunCoup" id="K1V2E9">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2E9"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004969_2_0_1"/>
    <dbReference type="InParanoid" id="K1V2E9"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="259"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="730"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1034" mass="116525" checksum="E0DAB377A12E131A" modified="2012-11-28" version="1">MPPVNGKRKAVVVSDSEEEVEPSTQGASQSPVKRPRVRDRHGDSETDEEDAATQRRSSRRQFSRVNGSQVNGDHDSDEDEDEDVIPSADYVAGSVVRIKLKNFMTYDFVEFHPGPHLNMILGPNGTGKSSIAAAIAIGLAFPPKIMGRAHDLKSYVKQGSEVAAIEIELKGRRGKRNSIVHREFSRVDDKSTFRLNGRTCQQSLDKVSDFAKMNPVTVLHETMRAAGDSRLTKWHEALVEKGKVTESYDDDIAKDIAARDQLQRQVDELAPDVENYEARAELEAQQEWKHIVKLGLEFEQAKEIKAQKKSEVAKAKLKLRAVESRVSPLQELSKELITRRNKREKNYKKAQDEVKDWRTAIRDGREAVNQVEAETKGIKDEMQRLKREEKRRLEKIAALKARKEHYERVLQEPQEDVRDKVKEKQQERKDLSNVQNVRLQKAFQLDPSIEFACNWIKAHEMEFEAKVHLPPMVSVNVPNRNYAWQVEMCTSMAQRKQRKVSLHLAVVNVTDETVNPPRPCSPEVLARLGFDGFAVDFVEAEPAALTLRSGAGLSADQVTAANITSWATKDDFTKASRSAYGRRDWTYTSSAPVSAKAFSLIGNGGAEARAPKHGAQDPEAGGENAGVSNDKGGTEVGLREWASSDAADCQDRTGRELKELQNEIQKYEKAHYELSDRLENTPSSETKKMELSEKLKTLARRRFNTLKALQAACDPAILRFHSVQTEGFGVRQAEANAVVVQEVVQVAEDRMKEHKEAVNKKVEEWQTIKEMLLAKAEAIHDLMKDRDSQALKDDIASVQAELDEIDDKLAVSLNVTRDVIERHERLSEQLGRIKHAVDKQQRARDRAHAEVTAILDQFNPALDALVSETSKKFSEAFEKMGCSGEVRVNRVEGRYDEWGIEILVSYRDNEPLAVLTANRQSGGERSLATVTYLMSLTEMARTPFSLVDEINQGMDKRAERRVHNQMVQVTCSENAGQYFLITPKLLEGLHYNPRMRILQVNNGVRLPDSADKSKRFGRLKACLEKYRAAHGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2T7</accession>
    <name>K1V2T7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2T7"/>
    <dbReference type="FunCoup" id="K1V2T7">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2T7"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="InParanoid" id="K1V2T7"/>
    <dbReference type="OMA" id="TMIMTEP"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="156"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="593" mass="64544" checksum="0029C4A256808FFE" modified="2012-11-28" version="1">MASPKDSIETKVERSDYATKEPKAVPTYDPNAPMSTPNYVPAKAEGPGGYDQGAELGNRLTHTLSSSSQRIRGLDFPSLTQQSSHLNNIYRAETAQGYIRPDEPGLSPILTGSTHHSIATTFSRQMTQLADKKIVTWTEGDKANPWNWGKARRWFYTAICAISVVQVAFMSAIVTGDFGDQMEYFGVSAEVINLTVTLPVCGFGIGPLLWSPLSELYGRRPLWLIPFVAYIVLNIGCALAPNIGCLLACRFLAGFFGSGPLTLAGGTIADMWGPSERGFAIAIFAAAPYGGPVLGPLLGGFIGKYANWRWLYWVNMCFAGGVWISLLFLPETFAPILLKRRAKKLRKETGDSSYVTEQEVLPRPISEIVVETLIRPFQMLVEEPILLLMSLYVSLVYGLLYAYFFSFPVVFVEGYGWDDAKTGLTFCSVLIGVALALLVTPMLEKRYLAKGENVTPEDRLPGMLVGGPWVPISLFIFGWTAPPYVQPHGGSWVGPCISGIPFGFGMVLVYFSANAYLIEAFPAYVASALAAKTVVRSAAGAAMPLFITQMFHRLTNGGASSLLGGLAIVMAMIPWAFAKWGAQIRARSKRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V336</accession>
    <name>K1V336_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V336"/>
    <dbReference type="FunCoup" id="K1V336">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V336"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="InParanoid" id="K1V336"/>
    <dbReference type="OMA" id="DERAHIP"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="236"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="358"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="504"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="662"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="863"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1023"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1148" mass="124512" checksum="9444DCB6EF7D1865" modified="2012-11-28" version="1">MGVKRKSTSGAPFEKKAKAVEPDTDEEIEQYAAHSTLVDPMIDPQHSDDSDGDDEDDDDVPEFDGMDQDEDDNVPEFNGDEAAEDGEEDTPAASSSAPKKSLYKAPTLKELDELRDAEASGGNTFSMQLDELLGSALLSTTPAAGLKTLLGAVHDLVHSLPEMAPVAPKKAVKKVPGVPFPGPKALLPTAEEVQWKLGFEKPTEVLVAGSWPVVGGYKKAKGEEGNIDIVVMMPSRAYYLGVIAQALKSAAKENGPLKGAEITWEHADARRPIISIRAGKAQGLKRAVDVRIHAGAPDVFPLATLYPSKSLIRADDEATPTPQTSTSLLLDTLHKPHLLHLHRLAQALGDRGADKFLALWRIWATRRGIARHLGGSGWFASMLLGWVVEGAEIGGDKPRRQRGLGKALPPWGALRAAWENLAHTDFEETPVFLGEANVPRTEFSGDVLVDATGTVNLFAGWEKGDVEMTLAMLEDTAADHFQDVFLRAETLGPATYDDVDASKAKTDAGLVAEAEQPRAIDRLAHRAADVVRQGLTDRARIVHTTVLSDTQFAVGLLLNGEEAGRTLDVGPHADQQEACAAYRALWGEKADLRRYQNGVIAESVLWTPHRPEQRAQIPFQAAEWLLKRHLGAVSVASRSANDSWLQIIQVPDAARDAVCVANSETQGFAPIMTAYQKLHSVLKNIDDELPLGVLNVTPASELLRYASVFVPHPVDANRLATAPESLGYVPVAEIRLQFESSPRWPDDLEAVQALKLALLERVARVLQPRIRARMAIALDADATAVEDQASLELLMDGVAFRLRIMYEKEKVMIERALEPARPGVPKPPAPPRRLLLPALAKWERRFEHEPRHHSTLAPMHHRFPSFSTAVRLMKRWTAAHMLRIEGEALELLVAHAYLAPGSLGAPAGATAGFLRTLEELAAWDWRTSPLFVPLVAVTRDAASASGRPRFPTAEREEALAAFSRRGEKHAWSIVTETDTSGTRWTGSIGPLIAGRVQALAGATLAAVRNTGPLDVPALFATPLEHYDAVFHLSPGTRAAQALKPEIPSGFRSAEAHEVRLGFDPAGLLAADIQRLYGDALLVFHDVNGGRAIGILFNPQRITPRAFKPLLGYNTAPASKSLVSLNKAAVIEEIQRLGAGVVTSVDVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3P5</accession>
    <name>K1V3P5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3P5"/>
    <dbReference type="STRING" id="1220162.K1V3P5"/>
    <dbReference type="eggNOG" id="ENOG502RZAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2442436_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3P5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="90" mass="9447" checksum="68646D332A9C8711" modified="2012-11-28" version="1">MDLIPEGSKVAAPGTSRKALIADDDEAWTAPSSPAFVQLKFPSPVDPTRIALTFQGGFVPTSVAVTATTEAGEVTGTVYPEDKNARQILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7B5</accession>
    <name>K1V7B5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V7B5"/>
    <dbReference type="eggNOG" id="KOG4522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003154_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7B5"/>
    <dbReference type="OMA" id="RPWEWTE"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="144"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1504"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1547"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1595"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1644"/>
            <end position="1653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1653" mass="182211" checksum="F8F9261CB8651E5A" modified="2012-11-28" version="1">MPPRQYLSHGVRTSHPTHSSKTTTRRRSNGAHTTDPGPLADPVPIEEFPPPAWRTVLNSRADLGYPDFYPSRPGYGQPEDELPESFVKSGFSSKAAVNVTAESFSMHGPVFQQLQSGGLEKLMELGQQIIEQRNASMPTFSERVFRIPVRVTYNDAKRLQFLAELANPAIPLTRLMRTPVPHGFKGVDLLETMFCPPQPTVRPTPGAAAQGPKPPSDPIPIDRALWFIRVLGANEITTHRGRAQPATVGVQAPSPVAATPSSTATAPPSAAPLNSNDWYTGEFTNAFTAWLRIQLGQLVLPARPAKAGAPPPPKAPAGVLGDEKSKARWLAKWQYSNQLLHQLYRKRLISPRLLVQWLSDFLGTANLAQLGFVSQLIHDNLVDVAEYVVVGRHCVRAACAKIDEIRASPARATMSKVEQLLINIVQVLYDSNPEVILSPATWTRHSARLSELLDSTTPTFQDLTRRNEALVAVPPVVDAGASPRRQQMVEVNKLDSIAAETDMAALCKSYFNGACAPTSPKIDLAKLEEKVFILVNWAMGLYQLGIHRPYAVYTLLKKWQEWHEEQRSEPFDFFDILYKWLDTSAAAQRPDNVLAIGIAFGEMTRQGMFSYGRYIRKLIAVGHSARNHTGPPSHHLELLRAMPIFVESKELCVQRRLILSGDSDPRERERGQAEEDAALESFKQELKEYVPEIFGLKRYGRSATFKEQIDYQLPSAASLNRYEFVQTRFWMFAAAVNAFKRQGPQPAMSASTFARIINVFNQCWAYSTTTDGIVGTEDEEILLIILDAIKRHADVWTCIDRWNEITTALMERFRVMQRKGRFFPPLAAVLLMLAQHNRVPPNAEEEVRAASEAHRHKSPATPAFPVDLDQSLQGLKQIIMSGDAAKASALSSKMFTRHGKFSAWSEKWWAAIIEAVQSADNSKADAVMAAVAHICEVEDVAGDGSLRPVVAAWLDTLVVATRLEVFGRRNVPPVVRLLLQLVVNRRLGSAVLLERLVFPELKHAATLASAAHPRLGTKRTHAIDWAVTMTQQLLLCTAHKTLPPQNLREAYIVQTARAAVFHASKVEGLISHLPVLVVLERSKVVPEKIRTQIGEIFRGLAALPQFKTAAFRNLDGLKDSFLSNDWIKRTSDSSLETGMVEGLKLMMSDSTTRDKSSTSLAIERGARYSAWRWTRVVLEMRVEFKRLTMRITNNDEPVEARQQIARIVRSSLDREASPDDMDLLVEAFRGADSVVAQEILSVGLDRLSVLLSQLLSAENQHQVEDTAAAVDQVLRVIRSAGRQERLEVATAAARDRLFNLLTVAFQSIERQVTSEDDVQLLPGAKPAEPGSVLQVVFKLLRFALALPSQDTIVTAAPRPDYAQLDTAFLHLAVEVFTDLDTMRDLLIYLVDSTPTSSQAAVYQALSYEMSTSAVQDLLTAHPSFASALPRPPPTFRAMALSGSHVAESEGIALDDRPWEMMEHLTPLETPSHVDVFLSSKPLKDTASIPIALFRPQLTRDEVPVLSTSPEPWDYASSERNLGNGAAGEPVSARQMATILYAPAPAEEEPKLAPAAPKRARNATPVSVKGTGTTTDPIDILESSEEDEPLQKKPRTAAAAGKTTRASTADKAPRKAAPAKKAPAKAPAKAPAKTTAAKSKTTATAKRRRSGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V827</accession>
    <name>K1V827_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000348">
        <property type="protein sequence ID" value="EKD00120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V827"/>
    <dbReference type="HOGENOM" id="CLU_894842_0_0_1"/>
    <dbReference type="InParanoid" id="K1V827"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851676" evidence="2">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="32449" checksum="24A31A1E1B022099" modified="2012-11-28" version="1">MRTTTAIALVAATTATTALAKDAGGFQLLYTSSANVSWCIQPRAEDDKGNPRPPQVGDQLIFDDCHYAVEGLKRGQIWSWLGNQLQVQLGGSSSFCLGLGERVVLASCSQVEDGQGEDGDDQGQNEGDNEAAGAMAPKTTVAASLINWKALTVAPGSHATAAADPSKTAGTAGEGGKKEEVKTKWLFPFDGKLCVSKDECISAQHPQDAPTSITPALTITDRDYAAHIGFARTYNPHGVDAASQAGAGRVGGEGVQNQSGSAQGHKVPPSDNGEEQNTDSHNGLGRFGRIGLPAKVWQDDGGKNDETKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9A7</accession>
    <name>K1V9A7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 39 (Zinc transporter), member 1/2/3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9A7"/>
    <dbReference type="FunCoup" id="K1V9A7">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9A7"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="InParanoid" id="K1V9A7"/>
    <dbReference type="OMA" id="CWVEGII"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="45539" checksum="F9533AEEEB6D333B" modified="2012-11-28" version="1">MAPTLASVATTATQVAAAAATHVIIPILKRAEEEAAEAAGGEEEDACAASYDDSHWGLRIGGIFIILATSLLGTLAPILLRSSRVVPRAFFEFVKYFGSGVIIATAFMHLLAPAFDELGSECLSGTWNNYDWAPAFALISCMLMFFAEVAAYRIGTQKLEQIGVNYSSHVHDETDAHAHDHRAPSVVAGQSNPANLHSHALEHEIAHEHHPNINGHGLGHHGPMPDGPTEAEIYGESLDGGKLRKKVDLESGDSDSALTLGPSDAETAAQIVGVAILEFGVVLHSIIIGLTLATSDEFIVLFIVIIFHQMFEGLGLGARLASLELPKHLWWVRYAAALLYCICTPVGMAAGLGVRKSYNGNGTANLIVSGILDAISAGILLYTGLVELLAHEILLNPRMMKSSNSKLAYVFICMCLGAGLMALLANWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAH2</accession>
    <name>K1VAH2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAH2"/>
    <dbReference type="STRING" id="1220162.K1VAH2"/>
    <dbReference type="eggNOG" id="ENOG502RZIB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_1_0_1"/>
    <dbReference type="InParanoid" id="K1VAH2"/>
    <dbReference type="OMA" id="AVYIQHQ"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="46784" checksum="91966CAAC47D8CE2" modified="2012-11-28" version="1">MRSSSTTSMASVSAPIRTRAFVGPFIVLIGVVLSSAIQTEVASYEASTLGFDKPYFSFFVTHSTFVIAFPVHLALVSLKGGLNGAPTRARQLVRGLRAVLADQLGTVPRWRVLAKPFMYKIVPLTVLVTIPAVCWFAAMALSPAVDITALYATSAFHTYFFSMLLLGTRLTRTTLGAIAVAFAGVLAITLDGGDGGNMGSNRMLGDIIMVVGGAALGLYEVVYKMVLPESQGGVSHADTHDPESSGSDDEEDEIVLGSSRPVATTPLLAGSKPPSPNGSLSDIVPISSRANSPRTSLNGPRPPSYATHTPLRAREAHHHVPTLPVGLHSNFLVSAIGLATFLLLWFPLPILNMTGMEKFELPSTAYLWGIVAVVAVCGAIYNAGLMMLIGLWGPTTSSVANLLTIGLVAIADALWMGRAPDLQTVLGAGMICAGFAVLLYEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAI8</accession>
    <name>K1VAI8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000327">
        <property type="protein sequence ID" value="EKD01040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAI8"/>
    <dbReference type="STRING" id="1220162.K1VAI8"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434244_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAI8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="128"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="630" mass="69480" checksum="C246E04AC0427611" modified="2012-11-28" version="1">MRIPTLLAAAAFAYEASAQDRFILGSSNALTVSRMDPIISPGAFGGHVHRVYGGSAFRTMAADGIHRLCHHCNTLLLAYCLGGVLGTDSKTRQVPQPPAATASPSLPLISRSLRLRSLTPPDVLNDPQDQLDKSHCSTVKVLADKSNYWVPALYFINPNGTYSMLNGEPRIYYLLDFDKSQPLAAFPPGLHMISGLAMRRDPGAKQAQGIQLTVDAYLNVPTNNQFIPNGTVHPDPPGQGYVQLNVRFPNCGWANQSLDSWDHFSHMAWSVNDKGEWDPMGRKCPDTHPIRYPQIFLENFYRLEPWQKDQWNRTGPSVILANGDTTGATFHGDFVNGWEPEVLQRAINECRTAGDDLDKCKAFDGQLQDPWNKTTGAPADMYDCRLQSQIPAEDVGFYRPLEHLPGCNPRWDWDGPTDHRSITEGRDACPWFEGEPGWTSPNLQYWAQREYSFPIVLPGVDSSSVSNLVTSVGRWQGTGARIVPWPTDQDGETPQSVPPNSKGYRGVLVGSQAEVDKAAKTKDDKDWQPSVFGWDSPPGHWEQEKPADSPKPAPVDTKRYEKMAATTHQTATYACATTTAWAGLPCGPEYVKDAPKAKDEEHKKHGAGTRVLPSVACVLSMLLSVAYVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAQ9</accession>
    <name>K1VAQ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAQ9"/>
    <dbReference type="FunCoup" id="K1VAQ9">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAQ9"/>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_600184_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAQ9"/>
    <dbReference type="OMA" id="FESTHAK"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000050">
        <property type="entry name" value="Related to MRP4-mitochondrial ribosomal protein, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="456" mass="49760" checksum="F29586A3BA734A5C" modified="2012-11-28" version="1">MNPATTPLRAALRGQALSGKCSTVLCQRNLQLRTDSGRQSSGGRPISGGRQKSAMKAVGTSEAVSVVITTCVLASSEAGTGNKAYENVRSAADGLTELTSLGRRANITAKRALSTTAPMLGAEERRHGNTRSKGYKKYEDPLAEFEANAWKGGLKRARDFRQRMADIADTPDAKLPLYVPPEATKAAPIPTPKDPKTATLSTLMAAGAALGHSQQLLAPSFTPYVYGNRSGLSIIDLDQTLPLLRRAAALVRDVVEADGVVLFVGTKGKHRKALLQARERMGDNALVRDVVEADGVVLFVGTKQKHRKPLQQARERLGDNGYSTLKWWPGTLTNAETYFGPDPIYNQTYLPDLVVILDARNSRSAIRECTGRNVPTIGIIDSDTDPRLVTYPIPANADSARTLELITGSLSLAGQEGRNARLRKEEKRKEQAKRDREWRREAYERYDQERAPAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAR0</accession>
    <name>K1VAR0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serum paraoxonase/arylesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAR0"/>
    <dbReference type="eggNOG" id="ENOG502RYG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033924_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAR0"/>
    <dbReference type="OMA" id="NDHHYRE"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44294" checksum="F7289893DCE9EC7E" modified="2012-11-28" version="1">MAAQLARAGLFAIISYLAQSAFHRGKTLGAVRLALGTETNFHPSANEVKIIPDTINCEDLHVHQGLIFAACQEKDGTRKGWFPALHNFKDPSQAIYGNLRIIDPETDTAIPLKIEGFGNRAFTTHGIDVVADPHNKAAVFIHAVNHAPNTDPEGPAAASRVEIFHHVLGSGSAQWVRTVAVPVITTPNDIFSVSPSEFFVTNDHHYRDGPMRLVEDLGTRQVAAWSSIAHCDADLDYTDDVGVNYKLALEHKLHNNNGLGHGPDGTVIINDAAGGAMYFAKIGEDDQLQLLPGEIQLPSTIDNPFWFADPYPEVSHDASGAVNAGLQHAITMAKTLQEDGDIASVVYLSKGTPGAPAKEWNTTRLFADDGSKLNSASAAVLVAIDPKTNGGKKQAKLYASGFASKGVLSTVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAX6</accession>
    <name>K1VAX6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAX6"/>
    <dbReference type="HOGENOM" id="CLU_1094939_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAX6"/>
    <dbReference type="OrthoDB" id="2596508at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="254" mass="27196" checksum="C54CE3068D221A6E" modified="2012-11-28" version="1">MAVPSLGALPAGRPDYVYPRSDWSSACWGPPNVAAETLDSNLFQLGAKFASDTVQQALRGQIPWDKVGINGLYLSIIDVVLQEQVIFVDSRLTLGATVCVKKRQYGQLSTFSTPPPCIQAMSYGMKRYCSAALIAGFRLRIDAGTYPPPEAFVRVDVGFLGDYMPTADRLAQYGMGIITGSVSAKATEGELLARAGRWAAAHPGPLPPNPLLSGPLPQPVYPPLGPIPDTNLEVTEAGGLTTMNAWHSEESPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VB84</accession>
    <name>K1VB84_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acetyl-CoA C-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_04378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VB84"/>
    <dbReference type="STRING" id="1220162.K1VB84"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="InParanoid" id="K1VB84"/>
    <dbReference type="OMA" id="MTAFPEP"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="295"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD01300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="409" mass="42939" checksum="C6DC4898584A191C" modified="2012-11-28" version="1">MTSSITNALPSLGKARLLINSPDDVVVVSAVRTPFTKGGLKDMLPEDLMKVVMQESIKRAGVKPELLGYLDSKLTTSDVQVGTVLPPGMGATVARMAQLSAGIPYTVPLATLSRQCSSGLQAVVNVANSIKVGNYDVGMAVGVESMTANYGAATMPPAFSDDVMENPESADCLLPMGITSENVAKEYGISRKEQDEFAAKSQQKAFAAQKAGLFKEETVPVKAHWTDPKTEEEKEIIVDSDDGIRDGVTAESLSKLKPAFAKDGCTHAGNASQVSDGAAAVILARRSTAQKLGLPILGKYVGSVVVGVPPKIMGIGPAAAIPQLLENYNLKVDDIDLFEINEAFASQAVMSIKHCGIPFEKVNPVGGAIAFGHPLGATGARQIATAFSEAKRNGQKTIVTSMCIGEYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBQ1</accession>
    <name>K1VBQ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBQ1"/>
    <dbReference type="STRING" id="1220162.K1VBQ1"/>
    <dbReference type="eggNOG" id="KOG1487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_1_0_1"/>
    <dbReference type="InParanoid" id="K1VBQ1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="99"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GTP binding protein second" evidence="6">
        <location>
            <begin position="195"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="980" mass="104891" checksum="F09202B4872BDA72" modified="2012-11-28" version="1">MTTAQKIKDIEDEMARTQKNKATEYHLGQLKGSLLLLSWRAPLYRRILTSAKLAKLRRELINPPGGGGGGAGIGFDVARTGVATVGFVGWKIDSDVGSDAASYEFTTLTTVPGTMVYNGARLQILDLPGIIQGAKDGKGRGKQVIAVARTCNLIFIVLDVLKPLNDLKILMDELEGMGIRLNKKPPNITIKKRETGGVQITNTVPLDIDHATIKAVLNEYRMSSCQVSIHEPNATIEDIIDVCEGNRVPISSKLWLNVDDELKEEMWKKLDRCKVENFCDAIHKDIKRQFKHAMVYGTSAKHSRGQKVGLDHVLEDEDGQAFAVIKEIGHTTSRVATAHTDTMASAQDEGSVSKKRIVMFVSAVGVGLARLVGAPYRPNDSGYAPQLAAKLNITSTQSNLVGLGGNLGVYLTGPFTSPSDELRPLLSATLLNFFGYLFISWFYRGVLPIRTSDDIDTPASPLLLGLLILSMFMTGAAGSAGLAAGMNAVAKSFPDKLRASATGSVLAGFGLSAFFFSQISRTLGGSTSGFLRVLAIGTAVPMFIGAILVKPYPPAQPSEYEPVHCDDPDDHRDADLSLSRQVSQGVPAETLAQDPRFGISNDLELARSSSGSLAHRNHEHDGDRDSSPPTPTDPLLQRSIGHKRYDSNESLPPTAIHYSPFDLIGRTDWYLLFSILAILCGIGLEWINNVGAVTLALARDGWDYDPKKVKVLQATQVSTISIFNCLGRVVGGALSDFMRLRFGIKRIWFLPLVALMFLGSQVAVIDTEQVKHLWMVSASLGFAYGSLFNALPMLVLEWFGMTHFSQNWGWTSVAPIIGGNVFNMIFGKVYDSNTVGRVGEPSDLGLPGLGHSIRRSSISVGVARDARDISGALGPVSRAVRAALGASGPARGVVTRGGGANAGVSGLVASAGTAGDASGPGTIVAQFARAGTGSGDRSHECLLGAACYATAFKVSSLGCVVALILAIIAGVRRERRAHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCB8</accession>
    <name>K1VCB8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCB8"/>
    <dbReference type="STRING" id="1220162.K1VCB8"/>
    <dbReference type="eggNOG" id="ENOG502SVEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063099_1_0_1"/>
    <dbReference type="InParanoid" id="K1VCB8"/>
    <dbReference type="OMA" id="FTWPTNI"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854069" evidence="2">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="215" mass="21484" checksum="FD877FF0E81AA370" modified="2012-11-28" version="1">MFSLVFSVVTTLAAVASGQALTINTPCQPVQLSWANGKAPYYPSAIPAGQASAAPLAKFPPQQGTAFTWVVNLRSGTDVTIRITDATGTTAYSSPVMVQDGFDDKCLSEAVNVTADDRSGSGSGQTGGQNGQNQTNAPPSSNGGNPNGSQQQPQNAQPGQNQTHASPTPEGNATQSPAQNQPQTSPAAANSTASALTASVAGAGVAVAALIAVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD29</accession>
    <name>K1VD29_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Programmed cell death protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD29"/>
    <dbReference type="FunCoup" id="K1VD29">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VD29"/>
    <dbReference type="eggNOG" id="KOG3431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_2_1_1"/>
    <dbReference type="InParanoid" id="K1VD29"/>
    <dbReference type="OMA" id="IANMAMQ"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15392" checksum="A9AD398E9A49F819" modified="2012-11-28" version="1">MSFQLPAGMRPAQAPQKGMSEEERAQQQQQQQQREEMKRQMIQAMLEPEARERLSRISLTRPQLAQQVEEILVRMGSGGQIRGKVSDEALKGLLEQQVSSSSQPKPQSSAPERAGTRRLGGGITRKRDDSDSDEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD81</accession>
    <name>K1VD81_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_03764</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 11"/>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD81"/>
    <dbReference type="FunCoup" id="K1VD81">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VD81"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="InParanoid" id="K1VD81"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="41"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="386"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="219"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="79"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD01945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="550" mass="58315" checksum="ACCB5DA42FAA5348" modified="2012-11-28" version="1">MFVRAPLSTNLLRPLSHPGSSYTAGRHLIRVRHLASEAGAYDVAVIGGGPGGYVAAIKAAQEGLKTVCIEKRGKLGGTCLNVGCIPSKAMLNNSHIYHTITHDTKNRGIDVGEVKVNLPNMLAAKDASVNALTGGIETYLFKKYGVDYIKGTASFESPHKLNVALNDGGETQVEAKNVIIASGSEVMPFPGIEIDEERIVSSTGALSLKEVPKKMIVIGGGVIGLELGSVWSRLGAEVTVVEFQGAIGAGMDGEVAKNFQKILQKQGFKFKLNTKVVSAERQGDNVKLKVESAKGGKEEELDADVVLVAIGRRPVTKGMNLEKVGVELDPKGRVVIDDQFNTSVPGVKCIGDATFGPMLAHKAEEEGIAAVNYIKHGHGHVNYDVIPSVVYTHPEVAWVGKTEEQLKADGVKYKVGKYPFAANSRAKTNQDTDGFVKHLVEKDTEQILGTHIIGSDAGEMIAEACLALNYGASAQDVADTCHAICALAPDASPLAPFLSRDCAQGVEASGRTKCGTPSSLHEPQLIPQHPTLSEAFKEAAMAAHGQPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD82</accession>
    <name>K1VD82_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD82"/>
    <dbReference type="HOGENOM" id="CLU_402352_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD82"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="465"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="570"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="684" mass="74229" checksum="6D694F4157988B98" modified="2012-11-28" version="1">MVPDPPPTPRLNSLLSGFQVNSDPLWGTSSEATAILAQVQAWLASKNASLQPISDVPLIYSQAVMEHFGFTRRDMRKPGSFKYLCGWPQLTTPRKDGRLAPVRGRKGWGVHPALSFNRVDGYNPTVYLFFPSLAICTECKLTASFPGRSLCKNASAARFPTLFSTPSFARNKLGDCNYCKSRDLVCSARNWTFLGSTGTLPDKHTLDEAVAYEQWMEDHAVDTEFTQQLVKRKRASVGGTQSKKRTNPRVSSPRSLPTQSASSHRTPSPQLPPTPDSRPTVTPAQPSSAASSLGPSNHDNERRNNPPNVVNGPGFSSSYHPTPATGNRLFPVGTIPATNSIPGTSVTPSPIPPAASSSVINLGNTANETSAPLLGSSQNPLSISLPTPSSLPGSSLNATPSSLPSSSLNALGITLPTPRHPEEVMAAHNLLWTEYQLQQTRLAAIPSLESHITQLSASQASQASLSALEEELSSLRSTHTSVEGELQLAQVELTVLRAGQRARDERIAALERDVTGAEQRAEAMKQRMQQRAAEMERRARAGEAAAQHAQFADERTLVVQQTLGRAEARIRALEADVALSKVQAENARVELVAARAETAQAREESSVAKAEAERLRELIRAEEEPEDGEISDDPIALLLVRRKLAQTQKRLAAEQKEKQALTAELARVRAELERATCPDIEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD95</accession>
    <name>K1VD95_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD95"/>
    <dbReference type="STRING" id="1220162.K1VD95"/>
    <dbReference type="HOGENOM" id="CLU_607185_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD95"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="451" mass="49916" checksum="CA32FA3556E85D09" modified="2012-11-28" version="1">MTPSIQDHDPKHQTSDVPQTLSGSESCFDGGLNQPEQTTPPSPPPYSLFTKKQRWLILGLGTISVSTTHLNLNLHLHPSHTKFTTSSRLSTFSGFASNIYFPAIPTIASSLNTTVENINLTVTSYMIFQAITPTFWGAVQPLLPDSDLAMPAELGIGEHDCYRFRHGRRRDDARGAWRRHGHLPDGSPTAARYWASARRCIRPDAWVARHILVPRHLRGRVLDRSGPVPPRDAAESRRRWIDPPSTHLAGTVRQGTRAAAPRADNGVQGAQARHYRSHPNPLLPRGVRDAPLPVSALWHVADDDHGASLVVRKGIRPERLGEWAHVPRQWVRVHARHADDGQDPEPRLPPRQGRVYGRPGRLPDRARKAAYRLDLVAAAVVWRAAVWLDAGPAAAYCRAHCGVIRARVGGHVGAVCNFDVSRRYLPAAELVGDSGAEPRPLPRWRGRDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDL3</accession>
    <name>K1VDL3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDL3"/>
    <dbReference type="STRING" id="1220162.K1VDL3"/>
    <dbReference type="eggNOG" id="KOG3122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503615_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDL3"/>
    <dbReference type="OMA" id="NNYAGTH"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="56772" checksum="1D031235636F57A4" modified="2012-11-28" version="1">MPGQRLRPTKPTRPRASLVAAAAASESPSTSAPAAGQQPLFLDPDADDEADEKHDAMEDTKEDTREPAPAATPAPALTQAQAPTQPTASASSSQVQGARTEPVKMKFKPKMPIRRAVQEDVKTDVATSSRGRGGIRGRGRGGMRGGRGGSAAVSTIAAGPFGGNRPTSRRVVAPPPPSRGMETVAVEVYSDNEDGSRPGVIDIDAVSGLSESAPTSVYRARDLDGGKAAAKAKEKEKIKAQKERKRRQKLVRAAVAGDVPGDVFVKAEPVSPSRPGAPLPTTADDDMNMEREGDSMIPADQTQDRDEAGRRVRALTSVTDISTVSGTPDVNEAQRVDLSESEDEEFEEDLGGDFILVPGGEHPEDKLFTFQFPHMFPKFKPPPEPVVDVDGAAEGAAGAGGAAAGATGAGAEAEKKEEKPKLAAAAAGRKKPTPPPTGRIGSLVVLKSGKVKMVMGSGDSAVVMDVSPGVSPSFLQTLVHVDQKSKTLAVAGEVHKSYVVTPDVDRLLDELFINGGETPGDREKRALRQVKMERGVKMELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE14</accession>
    <name>K1VE14_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE14"/>
    <dbReference type="STRING" id="1220162.K1VE14"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_35_0_1"/>
    <dbReference type="InParanoid" id="K1VE14"/>
    <dbReference type="OMA" id="QNGDIPY"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="306" mass="34567" checksum="9FAB30AE68FCFECE" modified="2012-11-28" version="1">MDALGRVGKEDDAIPVSEYRTVGLPSNVDIAYIEAGKIEAGNTNKHTLVLLHDFPSSSAQFKTLIPRLATRYHVLAPDLPNFGFTSVPMSYKPSFESMAKAIAEFLKVMGVDKAAFYGVGYGADVVFRIALQTPDVIKALVVQNGNAYEKGLGDAWKPFERWWQGEGAARDELYQTLGDPSWTKHRWYVGVPDSDVHKIDPMQYTEAYRGTLRDDNKRDTQFTLLWDYQENVKLYPKIQEWLKKNTPLLVLWGRGDDVYSTAAPEGFKKDSQYAKVVMMDGGHFLTETKVPIIAKEVRDFLEGVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFA8</accession>
    <name>K1VFA8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFA8"/>
    <dbReference type="HOGENOM" id="CLU_811797_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFA8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="342" mass="36327" checksum="249B99A899E48B2F" modified="2012-11-28" version="1">MIPYPPYVPPSPPLPVSALPRRRDSLPSPPPTPVSPVPVSPSLIAVAVSLGHGEVVAVETSRAAPPSPSSWPPPNSVSNPLSTESADRAERPPAAPMPSFKPPAHYLNRSSRSFPTLTFPSANDLPRPGFAHAAVQTDPAANRPNLRLSTSFSAQTHLSHLSHVSHLSHVSHLSHVSHVSQVSQHTHASTLSCQQSCPCSPPCSARRYRLIETGIPSRIPKFPTEVIDSDPPTPDSPLSSASSGSSKLPLSVSHLSSFLATSFYLLFNLPLVVILSHGVNEASALRLRLDCLTHLFPAHSLTLQALWRGLLSATAVALAIPSPPADRFHTRTLLTSSAAYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFJ9</accession>
    <name>K1VFJ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_02804</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFJ9"/>
    <dbReference type="FunCoup" id="K1VFJ9">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFJ9"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="K1VFJ9"/>
    <dbReference type="OMA" id="HFVNFQR"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="222"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD02860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="660" mass="74299" checksum="3B30F20118BCB975" modified="2012-11-28" version="1">MSGNTASSEVNKTAHEFDKTNLDSLLSRRFFFAPAFEIYGGVAGLYDYGPTGSALQANILDAWRKHYIIEEDMLELDTTIMTLSDVLKTSGHVDKFADWMVKDKVNGEIFRADHLVEAVLEARLKGDKEARGKKVEEKEETDEKKKKKKKNVKSEAVKLDDKVVEEFEYILAQIDNYTGPQLGELIKKWDIRSPANNELSEPVEFNLMFQSDIGPTGQIKGYLRPETAQGHFVNFARLLEFNNGKVPFASAQIGKSFRNEIAPRQGLLRVREFTMAEIEHYVDPLDKRHARFNEVRDVVLALLPKDVQQEGRTELTRMTVGDAVEKGIVDNETLGYFLGRTQLFLTKIGIDAARLRCRQHMANEMAHYAADCWDFEIQSSYGWIECVGCADRSAYDLTVHAAKTKQPLRVQQRLDQPRTVEKLDVQYDAKAFGIKFKKDAATIKSTLAESDKERLQCIKDEMDKDGKSLVKCADGKEYELTPDLVKINPITVTEHMREFTPNVIEPSFGIGRILYSLLEHSYWAREQDKARGVLSFPPLVAPIKVLIVAISNDPALTAVIHDISIKLRKLGIASRVDDSSASIGKKYARNDELGTPFGITVDFATAKNGTLTLRERDTTKQLIGSTEDVLKTVDQLVKGTIDWEGASKVLQEYSGVQDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG20</accession>
    <name>K1VG20_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000399">
        <property type="protein sequence ID" value="EKC98011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG20"/>
    <dbReference type="STRING" id="1220162.K1VG20"/>
    <dbReference type="eggNOG" id="ENOG502S7NG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022092_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG20"/>
    <dbReference type="OMA" id="EHCRAWY"/>
    <dbReference type="OrthoDB" id="2568455at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="388" mass="42894" checksum="6EC837BD5F6E1CA5" modified="2012-11-28" version="1">MSRRGELSSPPPAELEQFAAACRAFYFSLTPPEGAADAISRILANLPPAHRATYTRLQSQLRSQAHLHHLRVRISTLHALLSATSPGGSLSHAARAEPGGPRARAERFERAAHFVRTWGAASGGLEPFFRGLWSVIRVQSRPKGGAGDKRVVWEVDDAILLESGGPEFMHEAVTTLKGVLGFEERALEAPPSLRRHSGVGPPSPSPTSPPAENEGERDRSGSDPFTDKKRRAPPPPVSRRARLAAEAPPTPLDMDGDDAAAEEADLNRPRFRLWVFPAYISDEEAEDLLSLFPTFRTRGKKADARLPTPTAPNEKSLEEGLGANERWRQTQIEGQTLLTPREECEDALGVLRSGTGRMWAGDEKRDEGWRGGTWFRFKRWWRRLFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGI0</accession>
    <name>K1VGI0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGI0"/>
    <dbReference type="STRING" id="1220162.K1VGI0"/>
    <dbReference type="eggNOG" id="ENOG502QR1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310133_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGI0"/>
    <dbReference type="OMA" id="QNLFMCG"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="733"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="898"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="963" mass="103588" checksum="39528FE1F2CFA61C" modified="2012-11-28" version="1">MKAPSSARRTSSSEAYSPYPQSSFSQPAAPARSNSNSRASGADSPQADMAPTQYKVARAISSCTRCRSRKQKCDGKLPACSACERAKVECIGFDAISKTNVSRNYLHSLEQEVASLRAQVAALTSNAADPAANRKREIASVTSQDMASFVGSGGLGSSGGLAIDPTLQGPEGEPPMRSPWDGPSHARRGSDYFPSTPHSDSIHSPIVGSGSGRAQNPITAGAAATSLTRMVQDAALRTGHAVTGATLLNSAGTPSHSGSIRGAGESPSDRSVIGKDSPLVEHADESQDNLHTPRSTHGHVPSHVPHSRGPPSVSSQSGSSKRGKRRFNVPPLPPQPAVERLVAAYVDFVGVTAPMIHIPTLGKQIQRMREGTDVDESDVFVVMMVLALSTMASSRFVDPPDELRACSEAFHAEALKHLDAVFEAQSYIGLQAILLLVWYSLLNPDKGSIWFLVGLASRTCVDLGFHNEHNSQAEKLDNLEIDMRRRLFWVTYKMDRLLSQSLGRPPSIPDGFMYVPLPALQHDVDIHAGQYGAPTGDVCAYKTVFMHTIKLRQLQSEILNHTYGVNGQPLPKQEWFDDMFERLKHWLATAPEPRGTVSSEGYAISFHNSCLLLFRPSRGNPKPGRTALSTVLASSSYIIRIYRRMQLNNRISWLWMTSHFSFMAGLSFLYAFFNLYSHGGGNNVPSLDEAMMDIESCLAVLEYLSPRVPSASQCHETMRSVSTAILEQLSKVKPNRNDLPSRSPGARFGAAISSARDDPLPSDASFPAPLPPTQLPYELTLLDNLFLNPITSHHKLSEYTNGVKKRKLDDGAAQPTPTQQPASLPPSAFHSVGPYGIAAQVTSAATKNNGLSLAGAAGAWLGTEAGQTASSAVVPGQPSGHAGAILDEMIINGVGHEQQQNGQAAPNGNGADPTQQQPQQPQQGQDQAAFDIFSFLMDEDSALGQLTTNWNALDVPPDYPLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHV6</accession>
    <name>K1VHV6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyamine transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHV6"/>
    <dbReference type="STRING" id="1220162.K1VHV6"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="InParanoid" id="K1VHV6"/>
    <dbReference type="OMA" id="PICTFMS"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="89"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="544" mass="59399" checksum="B175E15BB2F807D5" modified="2012-11-28" version="1">MSTDIEKAVGGGALAADNRADDPNDGNFGAQALESPDASTAPSEYHEPLKLTQTVLSTRSAREAAKQLQNFDTSPENPRNWPLSKKWGLCLTITVTGFISTSASSIAVPGIHQVMAEFGIHNLKIGTLITCFYVLGLGTGPFIFAPISELWGRQVAYLSSQFFFVIFAIGAAVAPNMAALIVLRFFCGMMGSVGPTLGVATCADRGLPVSIYAIGPMAGPVLGSMLGYWILFGGWRWELWFMVIASGLNFALLVCFSQETYAPVIQRKLGYRIQYPQPDPTSFLDRFSPKRIIHNLGWMSATVSKSEAGDAFSKALTRPPRLLFGNPVALITCVYYAYLYSIIYVFLISTPLLFGPPPFKVDGLFSYQWPRGTVALGYVGSAIGFFSAAFVAATQQDRIYKYLMRRNGDNGQPEYRFVLTQIGTVLLPVGLFIFGWTAQAETHWIGPVIGQVILSFGCMLAFNSIQNFLVDAFFPFHAAATAGASAMRSMFACVLPVYCAQMFGTLGWGWGGSLLAFIALVAIPGPLIMFKYGRRLRERYKFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIE2</accession>
    <name>K1VIE2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIE2"/>
    <dbReference type="eggNOG" id="KOG3687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001943_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIE2"/>
    <dbReference type="OMA" id="ICIHELE"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1440" mass="159846" checksum="C0B60A1C779F7E69" modified="2012-11-28" version="1">MGEREGDLDGLAGKGSTRPTVKLEVRRVSAPRRTALMGEPCFEWWTEECVELGPWGEVAPSGEEAEMVAVMPALPPPPVDAWTEGEAAAEVLDGLRAVVQANAPDSGRGLLKTGNVPLVSLFSTLVHRVPHAVGKLHARLHTSQSAAQSDPSFYHPKYIELLLDLGPNLDEETGAIIIDYYQRECLCLPFTSEWIKNIWKLLEAFALSNDLPIARERVSHLLYNDVYVYVEDLPESREQLVEQVIVPYFERWLPEETDDELLHDALEVLVRAAVSETMQKDDERRRERANRAQVDVEAEDANALPTQQMEEEMQSGSFDAIRKLLTKLANEPACKEVFGGEAVTSRLTSPLSPGIEPMTSPPLNPVRGRAPRESGLRSLMRTLSPAREPSPSSSSNVSVAHEDISKEKESRDSKDSEESKKIIPARKGNQHTDCKSVHAVKALIAIFTRLAFTSPQTRVNGQRPIRTPASARCIVVYRDLICLLFPLSETPGITKLPARCPRARLTILQWSMRLRADRQHRILFRGDINRFVAPFASILYRTKETEESVRQAMEQEEQRKRMRSQGPAGGRASTGGADEERGRTARPDQPSTRSRSRSKAAGPMLRTASIDSQQYNPLWCVPETLNFEAPPDNQPSEGLMTYDPYHPSLMVEGAPLVEGVWLPVSEYVRALNGLLRWESNWELVSYVLTFLPQQLGNKHFFHGTRATREVKGLLRVLCEGILETDNRWERRFQTPSFIKRPHINSAAYQSLSILISYRSTFDRGECDALVQSLVAGLEGNALLAKPCLQALTICIHELEGYVAKNMLAILQKTQQILSTPAVAVHILEFLVALGNSSLYRNFTDDQYRLVFAVAIGYIAEHNTRSDQSVDFSGARDAFTLSQHVIGLAYHAIYLWFLTLKIPQRQRHVSELVRGLLHAKSQRAPVDERTEVCFDWLARYTYGNADPKPASSFLNEMVMVQNGDNDTPPRSQSWLLGGAIITITAHARTGWATIQTTRATGQTAVVCKLENVPLLDLGEANADMTSLPATLMANRELVRDVNIDPVADQDVSTQKEPEVPAEKAIDGDIDPARAIALVKPKSDAQEPETYVWSGVTPSQRRKDVVIEPSYLALQLLSSYPNSSAAIPRGRIIPKEPKFDRALRGIEATPVINAQSIAVLYVGPGQTTEREILGNTDGSPLYLDFMAGLGRVIKLKGQMDVFTGKLDRVNDTDGAYAYAWWDDLAQIIFHTVTLVPNLPHDPEFNNKKRLVGNDYVRIVYNESGQDYAFDTLRTQFNFINIVISPYATRDVADGSGGPMGPSGLGGATSPPPGAAPGAGGAGGLDDWGGDSEDFFKVTLQRAPGIPDFSPIGEYKLVSKKNLPSLVRQMAHHAHSMAVRFQHVQNSSNAASAEYITSWRYRLRSIARLRELLPQIAEPGEEGNKEEVLRDFTRIFSPPQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIN3</accession>
    <name>K1VIN3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIN3"/>
    <dbReference type="FunCoup" id="K1VIN3">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIN3"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="K1VIN3"/>
    <dbReference type="OMA" id="GDEPYTF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="191" mass="21266" checksum="67350FAA46C1063C" modified="2012-11-28" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGEDPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVKEKWFPEVHHHCPGVPCLIVGTQVDLRDDQGHLDKLARQKQRPITTEQGERLARELGAVKYVECSALTQRGLKNVFDEAIVAALEPPTSPKKKRCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIY0</accession>
    <name>K1VIY0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIY0"/>
    <dbReference type="eggNOG" id="ENOG502TKZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259213_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIY0"/>
    <dbReference type="OMA" id="RICLRRE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
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        <location>
            <begin position="955"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1329" mass="146615" checksum="6D3E38831F3B6ED0" modified="2012-11-28" version="1">MMDPLIPFARSTPSLTSGTSDTPSIPMTDDSGLGTLRPRSPALIEFSDDGNPDPPRKPLAYSSGAGVTPAEKLRSLLRQMESDVRDPPPPPKPTPTQRRPATPQLIDAPIPTSNSNARANDEENSEEDSPPTPPPRIHSAYNARHEPDHEPEAGPSRPRRLPSRAVALQAAMNKMPEEKASPAPSALETFIAKHHETPEAWKPKHSGRTDWSTSRADSSATVQQFPSSAPRRRHAARRTTIEAPPDDSLAFAEGIQDPSIDMDDDSSLPAGWEEESSGAPDRSRGSSGRRSDRSTASADDPRRRFELDDSVDASPERPKNRFQTRRFIKADLSDELPDRPEPPRRSHRSTRSESPTEPESRTVRAERQWTRTSRSPTASFATAPQINPSTSLDMSLPQIAAESSDEDSGAMRNRASMFRPSSESPKSRSSESPKSRILRDPTNRTTGSSAYVDATSRSRDWASQVSKSQPYESFDDEVDRSLDEPEPPKRFNASRSRSSPDDADDRLAEEPEPPRRFGAHRRQHSQHSHDDLQGDSEPPRRLRASQSRDSIRDAANEPESPRRLRASRSRELQDEVDDELDEPEPPRRLRHSRSRELVQIEEEETVERSVDEDAGAVRVSRSRDMTTRYMDGSTEERHQSSQSIYEPLRWSQSRGSIEEPSLKQSRSRYDTPDESHGSVHSGNRYATPDESRVSDSRSRYDTPEEPSLKHSSSRYDAPEEPSMQHSRSRSDKMDESSMKHSRGASQSISRHSRSRYDNPDDTPPLRQSRSKEELAAEASRTSMHASQLRGFSFPRKRTRSDEAESAPAPPTPSPPKPLESSYLRPQKAAAALNTPVRPSGMRASALRKSARATPTPNRVRWSPDVEGGHISPPQSSFQFTAPKTTTPPKERSTTPPPSTSPPTSPPRTPAPPAPVEQSPLQPLATPVRGGDGNSSLRTPHPPGWFPATPLGADSGPSSDAYSTPAQASKTFEPGSAMRTPHPPGWFNPAAAPSTPGAKFFVTPAPKEKQPEKQEVRGVGVGAGFTTPLQPQQPYPLATPKPPGAWGWTPAAGSRLRNEITLDSSQSSAESSFERSLLGNGDVHRLRLSPKRKPASPKASPSTSPQQRRTESKDDSFEEVSLTTPKKGSGAWPPNDPPTPLSERLLNQSVAEDSFMDDSFLQADTSVMARVRSFLSPSKDADLRSAREKLEAATARSQASRKEIEDAQKAWLAALSALPAPSTSANAGTSTSTTTVVEIEKLAVKEKKEWPWIYWVIIALVEITVMWAVFRVTVDWVDAERSRTSSALVRRLPSGLGVFRRNARSSNLFDILELLGLRWAPQERRWNVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ32</accession>
    <name>K1VJ32_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ32"/>
    <dbReference type="eggNOG" id="ENOG502R51E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313127_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ32"/>
    <dbReference type="OMA" id="PPISETH"/>
    <dbReference type="OrthoDB" id="2586466at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="936" mass="102654" checksum="84D2852428FC4A4F" modified="2012-11-28" version="1">MVGLLGRPSRSYKDVEHNVDGLAPAGSRPYSAGIGEPPQPSINKLTKRAPSGAGGHTVKTYRPSLTEMHFKRQQMHDPFSTSAFNLGRKNKEQARAGQRAELDHILEPGYKSSFNYDDESTSVAGPSRLSSVRTAGGLSALSRRTRDKLNGEDNIHRSGSTASFANGNAAGGAKKSGVYLDATGRLHDTEYDPFAGVAELSRRRSRRRGAMRNRRNSASSSDTTSSSEESGQGRGARTLSRGSMTDDPDRDREEIRRRLDQERRKLDEVSGYAAARRRSMMSDRASGHYSGRGTPSVRSGYEDAGSLHPSIAPSGMTSITNGRTPRANQPSPLSPTLSKSSKAQSAVSGGSGASSRAAESQKSIEDSPRKHTETVHSSMPRTQRSASDRTITQKMKDLGQAQDSGNISDDEAEGDDGFQDATDDVNHVEEEGAVEEEQPPPSYESHQPPPQPGREAPQPQEPQMEEEGSESESGDESGEETASPLDRERDVRFHEPQMERITSLQSPQHPSHEPIRRVHSHTQTPSHPKHPRSVSSKGRLERPAGPARTQSHDYEQRPLYAEVDMVRELPLLKPRPAKQHSQEAAIEVIKTYTREPRESREAKEPPPVPKKDKGPTRVTGGFESMPLPKQRVTGFEAPRRPSGAPSGHSVAASHLATSHLAGRAGSIRSGVSGDSDDHERKRRPKPAERPREQLFPETPAQMKRREERERRELRSGKTPAGRLAADSVATSSRSRILPEIEIVDDDDPRIIFPTNGPSTQSIARGHTFRAPSLSLSNSHFPGDHSGPTSLRSDHRLNDDTSSRSIAYHDSSKAPSAIIEESGGGYLPSRWASGDKALRLTEEEKERYRPREWGGRKGDLGGRPDQWHEQNVPYGDGYLDARPRSASLSTSQYNHGGSADPSPTAKDEVKRGVKDLSTNARFSMFRAKKKLLRKADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJA2</accession>
    <name>K1VJA2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJA2"/>
    <dbReference type="STRING" id="1220162.K1VJA2"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601565_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJA2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="202"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50952" checksum="9BF912746DC45729" modified="2012-11-28" version="1">MSILMRHHNAQRQSKILICAQTNATVDKLCERAMELFPAGVGRNFVVRYGDDGRFNHSVQEVSVNGLARQHILVGESRQALEYQSGRELESYNAGLISEDEFTEIIDDIVVKLKALKNQRADEEAWRCEILRRAKFVFSTLGSSGADILDTCQFDLLIVHGANCVHEATSLIPLRHVDRVVLFGDRRQLQPMVTDVSRWIGYNRSTYERIIDGGYPCWLLDTQTQYHPTVYKQVSLVVYEGKVTNGQGTPGLLAWQSWAPGWGPNTIVNVPGEEKDTGNSFSNADEVKAVFDVLRSIFDLCLMEPKEVREQFTIGIVTPYSAQASALQRATNLLTVPPHISLKCGTVTALQEQQFDVSIVSFVRTYYPGYLNNLSEANVAVTRGTRLRVIVGDTTLMSEAQLWGSILECSTANLMEVSMRYMPEESLTCQWNESSNPRLQLSTSLPPSSHNLINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJK6</accession>
    <name>K1VJK6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJK6"/>
    <dbReference type="FunCoup" id="K1VJK6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJK6"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_11_0_1"/>
    <dbReference type="InParanoid" id="K1VJK6"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="18249" checksum="B0A2B78DFCF67560" modified="2012-11-28" version="1">MGDAGIRIYRASEADKDAAWSIVTAYNEEIGVIVRDTPEGFAKYFNPDSGLWLAEQDTSSGRKVVGCIILRPIHVPGVERTAEVKRLYVLPEARGLRIADKLLEQLDQFAKEQGYEWVYLDTKDDLTAAIKFYRRMGYEDCERYNDNPQATMFMRKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJV5</accession>
    <name>K1VJV5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000327">
        <property type="protein sequence ID" value="EKD01036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJV5"/>
    <dbReference type="STRING" id="1220162.K1VJV5"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="K1VJV5"/>
    <dbReference type="OMA" id="GLASCPH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="569" mass="63311" checksum="26023E06DFEEDC47" modified="2012-11-28" version="1">MTVAGAAAEALDRLPVVGPVLASWPKTTLTALIALAIFVALYAYLYVYRSLTLPFANVPGPEPSSFFWGSLMEIIKAPPSAMHEQWYAEYGSTFKYRAIGGDWRLCSTDPGFLSWMLGHDELFPKPPHSQKFLWKLLGPGLVTVEGDHHARQRRVVSPAFSTKALKDQVPIFFDKAAELRDKLLLFVEGKGDERPALPPSPGDEEKGGRKIDVMKYLGQMAVDIIGQAGFGYDLASLSGHPKPLAEAFRVMMGAGLNPGPIQVLKTFIPFLSFIPTRADKILEESNVIAHREAAAIIAERTREVRAAGDVDEGAFGKDLLSMLLKSNMSSDLRPDQKMTDEDVFAQVTTFMLAGNETSATALTWILWRLAQHQDMQQRLRDECREVNEGDYSAVNSLPYLEAVVRESLRLDSPVPATLRVTKEDVTVPLSKPIRGKDGTQMDSVRLKKGTTVMVPIHVVNWAKDNWGADSKTFNPDRWLKEQSPWKYQNPGVFANLMTFNHGPHNCIGYRFSIAEIKVTLFTLIRALSFELLPSRPKFEMKTGIVMRPMVVGQEKEGPQMPLLVRALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJZ0</accession>
    <name>K1VJZ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJZ0"/>
    <dbReference type="HOGENOM" id="CLU_424004_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJZ0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="646" mass="69945" checksum="28CC547C5E2F1448" modified="2012-11-28" version="1">MGARNWSKSFISPSPSPPSSPMSRDNPDSDDNDDATSALPRSSNLNRRLDLSTREDTAVVPDANPFSLSKKRSAAQKGKGKTSSVGSTIRPAGNVRPASARKAQASVPEDTFERKKGWSNGHGESIPPVTKSKRKADDGGSCKQIGGNRLPRDANLSLINSSTVKKTSSTSTSKKKAPKKKADDDISFHRLHSDESRNFPIIAGLARQRSLPTKAEKPEPDINLIVSGHGARVIRNTRKTGRSQPQDESSRSSGSSVSSVPSLQKWLAPDAPPQPSSSAAEQRHTASSPPSVEEDDVPQAGIEAPQAPETPPPSLVQPGASGYASSAVTTLKTPSTVRRVEREPTPEKRPEHIQLLEDMAEQLPQGYSLHEQADCRPELNRNHSTGQAYAVESPSPVAFGTPTQISTSKRLSQFRFNGSSAAIETSSYSHLSENLSKHHTSHPTANLNNTAGTGYQPQPHPATARVPLPPAFDSPGEPPQIRPLPFRSVARPSFTSIPLPHVLTPKFSSPAQVIRPRSQQRQPPQPPRVAPPYTQPQPRSQPHQSVRTIGSYVGLYQPKPTYPANSGKRRLTLAPGRTSYTGGAKVTTWEPTPLSQSRVTAPAPVQQNTYVPRHLRALQQAAEPMPPPRPAPVEEDEDWDADWRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKJ9</accession>
    <name>K1VKJ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000193">
        <property type="protein sequence ID" value="EKD04670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKJ9"/>
    <dbReference type="STRING" id="1220162.K1VKJ9"/>
    <dbReference type="HOGENOM" id="CLU_370532_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKJ9"/>
    <dbReference type="OMA" id="FQWNIGR"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="520"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="751" mass="78863" checksum="ACBA9BD33038982D" modified="2012-11-28" version="1">MATTTASANAGPSVPWLTQGQPEHHTCERPTVTRTTSLPSVSPTAPADQPPLGSQWISPDDPQWPQAQARWAQMQSQAQASTQPGTQPLPSTSARAETQAQAQPPPTAPTQVQRPATQLPPLPRAQAMWSAPLVPRPPQPVWLTPAEFAAEARKRKEKRDQLEAEMRSRSRRHERSPSIIEIPDSPEPEPARTGEVRRREGEDGRPQKRARVEDDSGSGSEPPPSAPERREAEDFFNALSLPPASQESQNGGARIEEIPESPERPTSTQSPAAHASTSPERTTATQTSASPPPAGQAPRWATQSSQQHGREQTSTEPAPRPEPSGTLATQPEAGSRPSAPALQETTQAVVVRGPASASVANGHAESSDQANARAQTSTMPNALANGATPAQATRHAQSSTSVAPATPSMPRTPAQSRAPVRAVQAEEPSTPGPDPKLEEHERRLAELEAQLRMLRELIPTPARPARPSEPLQTNGHVSQPQDFESQEPAAMQQASVPRREQSDGATSQPASSMDVDEDASTASTPAVTGTAAAPAANNTMTATSAAPNGPSEGASTATSTASQSSSSRGPQATAPVATPAQASGTSSAAQVPSTAQVAASAPTSDGQTPHPPSAPGPETTQRNQRSSPPPPPPNTQAPSAPQSAQQVCPSTPAAPDSQTPTSAAHPTQAEPTDDQLVTLKSCLAFMESEYRRADKEREALVSENEKLRKEVEAMKLANARLKLRVQITRERQSSGGSGLGMPVSQPTIDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKU7</accession>
    <name>K1VKU7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKU7"/>
    <dbReference type="HOGENOM" id="CLU_521939_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKU7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57852" checksum="73397D81C3C1CDC0" modified="2012-11-28" version="1">MELTSTPQITKRLLSASSSEPYKRQRTSDDDPAPHLPFNTAAPIRAFFYGVSDSVRWIFERGGGTTVLLAEAEYVVCASGEVKGRPETAALVSEDWVWSSWTTGRLMDPSEFPVPPGPAQYVEAATPALLSGDEVSAGHVSPKSDGSASSSTFSALALAYSPPSPEPSGAPADIVAEELVSSTPFSPPKSPPVATSEECDRDANIHLPTTMLVAHKKRVELLILALRKWNKRGSLLVFLRDTGITSAANLYYQHRQCIHENVPGLSERVYAPDVDSDDAECEGDSDAIRLPKTIPKHHKPRVRAIIQALHTWNGRGSLSDFLRRLPITSALRLYYQHHQTIAEHVPGLLERRDINDWTEEGSGYGEDLLPLPATVPLKHTARVWAIILALRRWDKRAFHKFIKGLDVPNAMALFYLHRQCIEDRVPGLSQLRQDNSDLQLPVESGETTETLPAYISSNHAPRVSLLIRKLKEWDKQGNLTSFIKSLHISSGLNIYYRYRAYIAEQVPGLPGYEAKAFPATDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMA9</accession>
    <name>K1VMA9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMA9"/>
    <dbReference type="HOGENOM" id="CLU_2251930_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMA9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="104" mass="11873" checksum="DB6D1FF3DB8D691F" modified="2012-11-28" version="1">MTHHDGHHDELQQDQTGKVPNPANETQVIEALDQQRAVNDQGYVKKVLENYIDNRKKEGDNDAKISEKLNIVLDRFPHYKNIVDEITNARGLPPCTQGDQSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMF9</accession>
    <name>K1VMF9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMF9"/>
    <dbReference type="FunCoup" id="K1VMF9">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMF9"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_9_0_1"/>
    <dbReference type="InParanoid" id="K1VMF9"/>
    <dbReference type="OMA" id="MHGKDVN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="258"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="393" mass="42341" checksum="D7E92818E62C1B57" modified="2012-11-28" version="1">MSTTTETQNKNGQDNAAVAADSTASTQPTPEVEGYRVYVGNLAFAATEAEVREHFSKVGGEILSVILPTRFKSRRPAGYAFVTFKDEADANKAVETLNETEIGDRKIQLQVARSKEENAERKAEILAKRKEAADAKRKENAERKAAAKAAKDAEKAQSSAQAGGDTTAVESDKSTSKATKSKKKKATKTKNSGRRRGPDDDDDTAVEDDKDSSKAVSKKKTPKDARIDGGDEDKEAKPKKEPKERKPRLQLTGENSKNTVFVANLPFTVDDEKLAELFSNLSIKVKSAHVIKGIRRLPGRRPFRGSKGFGFVELEDPSQQDEAVEKINGSNIGDRKVTAKVAQEMKPIEEIQAEQDKKDKEEAAKSGGATPTPAEPATSNAAASPAPATATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMG3</accession>
    <name>K1VMG3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMG3"/>
    <dbReference type="eggNOG" id="ENOG502RPRS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370138_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMG3"/>
    <dbReference type="OMA" id="HSTREMR"/>
    <dbReference type="OrthoDB" id="2596526at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="752" mass="80941" checksum="CEE05A99EDB2F174" modified="2012-11-28" version="1">MPSSVRSGQRAAVRRADVAPQSLGLEEELSFGSDEDLMETIGEIDVPTAPSTQELGALKKTQVNASTNSLKRPGKSSKASTLSLRSHKSKVTEASLASSTHLLPPLPPVPSGSTLDLPSEMFGDRDGETGSVGSRKHHKRGSLMGTFKSVKGLRKWRDDHSNKSSLFSHESNSPQTSTLSLSKMGSNTSSRPSLASSYAQTPVTPAYSAPQLAHLNLSHLSFEQPPTKGYPNAGPLPDLYSKQQPRYEPSLGNSSVTTDSSAPVETPPVSAPKVRASSSWYRSELSSAILPEFPATVSQLQPITVLTVPASFRQMTQNHNGRQIRWAPCTLVFTCFKMSVDDKPRGAADEHSVAHIHVLSAPSSPRGLSSAHSVGSLRRPSRNGGTPFVPDVTTRQEIDRRLLTRYSSAEITRDYAHSEGCDLALRVVFGDSGESKGAGEWQLEIKDMSQLKESMNQIKKTAIMINAEELGYGHAIRDAFDTPSVSADELAQKLSVHARAVAARRERKISEAIEPPSEAMGKLKLQASPKSSASQEMGRRDSYDVAQASAISRSRSAEEVRSPPVTAPAPLPVIEDTMDYPEPREEVSRLSFGSTSAFTFAATALAFPAPPSDLPSALAFPAPPSDLPSRRPARPLPPQPAVNVVAPSGVSREYEEGSGAATPMGRPPTPPRTRSGSMSSSKRTLTVHDSAVSVNSKDSGSSTSRLRRLRGKPQVVDIMAEFSALEAEHMPPEEEEEPIRDDRARRIRFAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMU0</accession>
    <name>K1VMU0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMU0"/>
    <dbReference type="eggNOG" id="ENOG502RXKS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_346530_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMU0"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="255"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="737" mass="79694" checksum="1F003A4865FC01D1" modified="2012-11-28" version="1">MSSGPSGTPFPGPPPLAAGSASSAGSMEPISSYYRQASEGAPSKRARMDVDERTKPVCQNLEDRVAGYESRLRDQEGMIASLTRWQQQQMAAPPPQGVPTPSGSRSGSGSAPVGFPSELAPPAMLSPSHDPSHAHPSPGGLSTTSFSDPRILPADEIVTSLINLYYTHVWPWAPILPRQAYSAPWGIVPHAIVVLALRLSDDPRLDRLPGGKQALRQAAKAHVLSHAVESTSIASMQALSLLALDLIGSEQGPSSWGTLALLTRSAAHLGLMTEDDPEPRRRLSGPQAPSSLAPFDPRSSLSSSMKRRGVQKRTAIVPPPATWEEDEARRRLFWLVLVLDRYASASTGWDFALRDSDIKRRLPSSDTLWFTPPPPGSPWPRAPLFAPVLHRDPYPPSVLANLSPMVFLIEAVDLLGRSHTLHSSGGSAEEARDAALALTAACRRWAAELPRLEGSLGLTVLALHHATLLKVNAYHAFPASGGSVAPFRDRCAESTSAVAELCRQQAGLGWRGASPLFIWGAWVAARVVFITRFVAHSADSGGVSGVSGNLASDPEFSVLLASLRDASRHWSLASHSAGRSSAGPGFEFWMLWLECCLWMRGSGLGSIRQRSSDRVCERSTESPFLRAPTGSYGLVRARTGSVRGSAGPNHRLCQIELPSFEDRDPFSRYTIACRQRADPIARQISPPLPSPQLWKQLRCSEDQADIHSNLPAWAVQPLLGDLHHWFDLPPNLFSEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN42</accession>
    <name>K1VN42_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN42"/>
    <dbReference type="STRING" id="1220162.K1VN42"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="K1VN42"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="27565" checksum="F8B44386C7E2A1B7" modified="2012-11-28" version="1">MAGTSTTNQVTSRLLPDKVVVITGASQGIGRAVAIACAENGARLVLHHLGESTLSDAESLKADLEKKGTSVTLVYGDVSEPTTAAAIVDAAISAYGRIDVLVSNAGICPFHSFLDMPLDLWSRTHDVNLTGCFLVTQACANVMAKMGGGSIVAISSISALLGGEFQTHYTPTKAGVKSLMESCAIALGKYGIRCNSVLPGTIRTAINEEDLSNDAKREGMEARTPLKRLGKPEDIAGPVVFFASDMSAYCTGASLLVDGGAAISLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNR3</accession>
    <name>K1VNR3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNR3"/>
    <dbReference type="STRING" id="1220162.K1VNR3"/>
    <dbReference type="eggNOG" id="KOG2890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1442025_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNR3"/>
    <dbReference type="OMA" id="WDEAQIN"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="188" mass="20538" checksum="C258780E1EB044E9" modified="2012-11-28" version="1">MCVPSGLLVAFTQIIPEHQIQLFGIIKARVKVGRSKAFVAADDTQTIPGIFLLISNVLVLVLGPSPYILIQFGFFVAWVYLRFYKLSENGEYRGDRSETFAFQYWLPPPVRYVLFRLVQAWDEAQINAYAALPGPGGARAEAERRRAVALRALDARLASSSPGPSTPAEAIAKAVPQSSATDQASPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNY0</accession>
    <name>K1VNY0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Inner membrane protein, Sco2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNY0"/>
    <dbReference type="FunCoup" id="K1VNY0">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNY0"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_0_2_1"/>
    <dbReference type="InParanoid" id="K1VNY0"/>
    <dbReference type="OMA" id="CRAFRVY"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="99"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="300" mass="32902" checksum="3EDE9C357F8BDDE0" modified="2012-11-28" version="1">MFRTGLRATARITPAVRPAAARAPIAAVPRFSRGYAQNESSEASSQAKDRAAVGPFTWKAAGLFIVTGAALYYYFTEEKKKVLERRPDPTGQELETKSVGRPQIGGPFNLVDQNGKPFTDADLKGKFTLIYFGFTHCPDICPEELDKMSDVVDTIDKEHPGKDIVTPVFVSVDPARDSVPQVKAYVQEFHPRIIGLTGDYDNVKKACKSYRVYFSTPPDAKATDDYLVDHSANKTPPYRPPSFVAGFVANSSIFFYLMDPLGQFVDAFGKSTTPEEVTEKVRDAIGKWEAAGGNKAAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP28</accession>
    <name>K1VP28_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitotic spindle assembly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP28"/>
    <dbReference type="eggNOG" id="KOG1820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000539_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP28"/>
    <dbReference type="OMA" id="NWKERKE"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000068">
        <property type="entry name" value="cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="245"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="652"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="913"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1288"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1148"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1531"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2007"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2122"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="588"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1234"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1546"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2148"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2188"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2211"/>
            <end position="2226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2226" mass="237650" checksum="D7737479C130EAAF" modified="2012-11-28" version="1">MDGEPPQEEDFSTIPLVERSTHKNWKARLSAYNDVISQSAKTASDTDPFFRPYLNDPGLLKKWCLDSNAVAQEKGIEAVLAIVTNSGETSAKLRPEIVPAIVEKALGNSRAGTKKKGTELCATSNFRSFGVQALGNVKPLLKALPKVFAHSDKNVRAEGIGLATALYTYLGPALMPALADIKPVQMTDLQKSFETLDGSGKGAGSGKPQRWTRKAQREREEAVGGDDDGGDVGGEEEPAVIDPMSLLDPVNVLDLFPGNLMELIASSKWKERLEGFEECNKVLAQPQNGRISDSNIGAYGSLVQTIGTKIQKDANVNVVMEAAKLLEGLARGLGKSFGQFRSSVMTGCLERLKERKANVVEAIGKALDAVFLTSKNPQVKAGTLGFLHRSLKVTTEAPGKDHIKPMAEALVGLLTDSAEPVRSAAAECLGTMMKILGERAFNPYVENIPEIQMTKIKEAFATAEIKYRPGGAKKAAPAARAPAAKPAAKAPAVVKKPPAAKPPSPTKPANDDELLQDFAAPPKKAMPARFANRLGKKPTPAASEESSPAPESPKKAKPVEDQLLDEFPEPPKRAMPAKFASRFGKKPAAAASDDARSSATPSPTKAPAARAPAAKPAPKAAPAAGPSKPAPAGKPGAAKALTSSPSEPVKYRYSSDDAMAKAEELIPASYHTKLADSAWKVRLEGADEMVTWVSEGGGEEVESEIMMRFLSKIPGWGEKNFQVSGKIFQVIQLMAEKSASFGKPAASLVIGPLTDKLGDLKLKKPAGEALIAIAEKTSLAFLLAQCESRPEKAPKAQADALAWIKQQVIDFGAAGIPLRELIAFIKNALGSPNALVRSNATALLVQVKIFVGADISGFIEDLNPTLLATINKEFDKVDGQTPPEPTRQQADLKEVAGGKGKGGKGGAADALDDLIPRVELDKLVNQTTVLKDFKSDAWKTRKEAFESLNALLDVKSNQRLKPTMGEIATVLKKAMADTNLSVKMLALGIITKIATGMGQPIEKYCRVLVPAVASVCADQKATTRTAAINTLSAIADAIGSLDPMYSGIGASLESVNPALRSSVLGWVASRLADDPPGPSADLSPLAGPVVTCLEDRNGDVRKAASVMLPFVVGNVGYDACIDKTTNLKPASKATIVPMIQAAAANAPSSSSAAAPPPTPAKAAPAAVATPARSLKAPTAKVTAATPRASVPRPSGIAPPGRSLAMKALGSASSHRPPSATGERPLGIPKSRMMAPRPTSSASSRPAVASPTGRTLPFVTSSPDAKANRLKRDAARWMLEAGARSDTLEYLAHQMEPHASADIFTLLFSKDHRAEEDFMTGLAVIAEFYDPETAGEFGLPDSELDAIQLANNDLALKYAAIRLMTNHTQVNNRSLEVISNVLDYLTRSGERLTEVEVRLFVPALVMKLGDPKFVPKLTPIFDGLDKIIPASQVVQLLVQYGLEEKGAGKTQKNESLALIEKAFKRRGSVLRKDERGFYEAIAKCIADPGTRPNALNLMALLQLQGESRNLQAVVAGMPTSAKDMLANRRNALSASKGASGIPRPGEAPASPRPGSRASSNASYGTPASSARISRELSSSTSARPQPRGIPTPAASRLPTTTPARGQPRGIPAPSGIPGSIKRPAARSLANDFNGAAAPSRAMQPLGRAAAPPPEPELSEAAMLIDAIYTEDVEEAAEALKATAAVLDEDEEIFIPEARNLINGLCFQLNNLPKDPAALLEPRSLRRMKHLMRTIHITFSKARLVKKVKLEGLETMFAGIRQQYASIEVWSEARGDDNQSANDLRDYMSMVLSSMISTPSREAVYTILFEGLVELCKDMTPNPDPKMGSEIGVILQCTYKRVRSIDADLRNERIRAGTLLAIIESLLQVIPPVQWRRRPKYGLPHGDLPLRVIKTLLQRVIVYTKEIGVGIYDLLQEQFGAEADMTTVYSYIFRIYDAAAANAAAQNAAQAPMQPPAAPAPVVAPTPVAAPAPIAEPVPSRADQFSRQESEDRVEALERNDHVERMERMAERMDRPPSLSHSRRRSGIDRPLSIASSAASRMSMGPDGMPKSPPPARDVPEAERLVRRLTDTRDNEQRLNELHAFMKLSPENEAEVRAAIASTLNPAAQTFVWRALDRRNAVDQPVQPLSPPSRSPVRELASPPLSATTSRQSLSGSISSRPSSMAPDEQMEKLKAVFARGSRVSLGGARTSSSPNMNRPLSEIDSQQVSPERSLHSSADRPKSEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPY9</accession>
    <name>K1VPY9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPY9"/>
    <dbReference type="STRING" id="1220162.K1VPY9"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="InParanoid" id="K1VPY9"/>
    <dbReference type="OMA" id="YDNETEH"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="597" mass="64502" checksum="BAAF5392044A55AF" modified="2012-11-28" version="1">MPYLHEYDYIFAIGVIFAALDAFNIGANDVANSFATSVSSRSLTMRQATCLAAICEFLGAVLVGAKVSGTIKNGIISLSTFDNNPGVQMLGFTCALVASATWLMIATYNSWPVSTTYSIVSALAGVGVALKGAGAVQWGWNNGKGLATIFAGFGIAPAISAGFAAVVYLITKFAVLDRKNSLKKGLMLSPFYFFTVIAVLTMSIVYKGSPSLKLDKLPEVTIALAIVLTALVVSILAIIFWIPYVYCKVVRRDYTLRWWHFPLGPLLWKRPAPPAHEDPNHQHVQDYRVYGREDERPAGTTAETVAVVSPPVAGAESGNNSIENEAEIEGKAWGSEKDVEAGEPQLHNQPAPARPARLAELEQEDQHKIEGSWFLPQNLWILIRYKIPGKLLKGWNFDVHEAQKGKTDKEAARIREMHENANQYDNETEHMYSYLQVITACTNSFAHGANDVANAVGPFSAIYYVWSKGVVTPKDTPTPTWVLVFGAAMLVIGLATYGYNILLALGNRLTLMSPSRGFSMEFGAAITVLLASQYGIPVSTTMCITGATAGVGLVSGGPKAVNWRAFGHIFLGWVLTVPVAGVAAGCLCGLFINAPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQR4</accession>
    <name>K1VQR4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">beta-glucosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 7"/>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQR4"/>
    <dbReference type="FunCoup" id="K1VQR4">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQR4"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="K1VQR4"/>
    <dbReference type="OMA" id="INICRSP"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="8">
        <location>
            <begin position="420"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="863" mass="95007" checksum="BCA31E84403F748F" modified="2012-11-28" version="1">MTTPFTTIPNEMDRSFLDADVHDIVSKLTIDEKIDLLAGRSFWETVAIPRLNVPSIKVTDGPNGARGGSFWKMTKATALPNETAMAATFCTELIEDTGKLMAEETKARGAVCLLAPTINIQRSPLGGRAFESFSEDPTLAGELAGAIVRGLQSGGISPAIKHFVANDQEHERSGNDAIIAPRPLRDVYLRPFQIAQKRAQPWAYMTSYNKLNGTHCSENEWLITDLLRKEWGFDGLVMSDWFGVYSVSDSINAGLDLEMPGPTIWRQKGMVKHLIGAHKIDPRTIDARVTTVLTWVQKLAKLHPDIVYAPPKTMEKSRDSEEEKASDAKFARQLAGEGCVLLKNDDALPIKKGKIAVIGPNAKAAVITGGGSALLRAGWAVTPWDGLKNNAPEGVELAYELGCIGEKFLPVLDEQFTTMDDKPGFDLVFHPIEKGEVVTDPKREVREWWDVSSMHLADFGHRNLGEHFTTELHAKFNPKESGTYEFGAVVTGHGWVYVNDDLVIDLSKKTPKGSAFFNNGTIETYNLRFVHDSRPPPDVAGTPLVITGLRIGARKKIDPDAAIAAAEKLAKECDGVVVVAGLNADWESESYDRPDLSLPYREAELISRVAKANANTTVVIQSGSAVEMPWIDDVKAVVQAWYGGNETGNAIADVIYGARNPSGRLPLSFPKRVEDIAAHNNYKSARTRTEYNEGIWVGYKHHNARKIPALFPFGHGLSYTTFEYSDLAVQASGERDEWRLKASVKVTNTGEIEGDHSVHFYTAPPPPTATSEAHPEVSLQAFKKVRGLKPGESKTVEVEMDKCEFTAKARDKKLTTDAVSHWDTLDGNFRVEPGKWAVEVRPDAATPGPHAEFECKEWSWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQT8</accession>
    <name>K1VQT8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQT8"/>
    <dbReference type="STRING" id="1220162.K1VQT8"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_1_1_1"/>
    <dbReference type="InParanoid" id="K1VQT8"/>
    <dbReference type="OMA" id="DPFENPP"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="194"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="370" mass="40307" checksum="86106ED0F8C91F81" modified="2012-11-28" version="1">MAEPTNPTTPDQILADVPGKWEKAKESGELLFFPSTERIVPGDFPFQIRLCPALAQKPTSSEDEKKDDKPKASPFQPPYIPELYVGCLEGIDGEKNMSVLLNKFSVAPHHFLLCPVEDEPQSLPPTPPELARTYSLVQAARKRGKSLLAFYNGGPGAGASQKWRHVQFTEGEAPVESWVRNVTFERKDRAIVHPDLPYLHIIHPLPDCPYPPTPDQLTELADKLAPVLMRSLDLAFDALRRAGLDKSQGWNLLVTDQHLHLIPRSAPNYALPGSGGTLEVNALGYAGQLLVKSEEQSAALDEVAKEKDGLTNILLKCGLDRKYGEEALTQDATQHGGAGSALELLDASDPSDASGASGEPKTETGKRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR15</accession>
    <name>K1VR15_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR15"/>
    <dbReference type="STRING" id="1220162.K1VR15"/>
    <dbReference type="eggNOG" id="ENOG502REAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470249_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR15"/>
    <dbReference type="OrthoDB" id="2563749at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF25">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="564" mass="61772" checksum="B4491C782CED3000" modified="2012-11-28" version="1">MASADDQGHHGPPPLNLAGVQVQVDDSLVDPALHPDFFKDGKFDDELAAAAVVAAAQQHEMLVQGVHNVQSQSVPQVGDHQPQPGGVDGVNANLNVMGGSVMDVHGNVHGMNDGINAQMEGPQAQAGPSQPSHLHVRAAEAQFAPFSRPIRTEGQTPHPEMLAFTNRAEFDVWFEGESSWCHFVQRRTTTPQKRAEERLRARVKAHEKMLASLPPSEAATAPPLKRRRRNRTSSIKEKVTFTCHHAGRYEAKHSTTLPREKLRLNTKKSVKCDCPARIVLTEMEDGECKVSYFWKHEGHDAYADDELESGRLPKVIDEWLVAQIEAGKDTDAIRRSLMMTEEEKSAYLAQIAQDPHNVDPDKPPALALTLKVKYPDIYNRFRKLRGPIKDFKPPKNPRGNRKRGANSSKEPESGESATPKSGEATSSADAAPTNEQQAQAQAQAQAVQAHAQQQQFGPQPVQQSTIGVDKAPGTAVQQMDQVDQVDIQDNLMQYDMEGFSLSEVEVDGLGSFQDGLSHEGLARALLSLPRAGQDDGGMGAAGVEELNTALRMAEQDREKWEVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSP6</accession>
    <name>K1VSP6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSP6"/>
    <dbReference type="STRING" id="1220162.K1VSP6"/>
    <dbReference type="eggNOG" id="ENOG502QSCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304059_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSP6"/>
    <dbReference type="OMA" id="IDWTRYK"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="382"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="962" mass="105093" checksum="B991802F7C20410E" modified="2012-11-28" version="1">MSAPSGVSIAAAPAKPEAAASSSSTPSASAASRPTSLPIQRAPSSGGATASASPAPQASAATATNDKKRKAHPTAASGAAKAGDDAASSSASANVAAPAPVPVPRPREAKRTRVHFSRVPHLCRPFLNGVEDPNANSDVHARLATIEEHRQTTPRRMSRRSQLKAKMFSILNQHRNPLLNRLVKSFPTSRLHPGLFPANLSTSTPVGRSGFGWGLREGRMISLSVEDNAELRDLLLTLRESGITKNHLEWLIAGVPGRRMADALVELYFRDIDWTRYKMNRPAFERRYVAFFDSIGRNPTSPKIDADTIKWLPLMFIVLAIAVLSAGPDIVPADEQQGWSRRFYGSARSGLEYAKALQRDNLEVLFAGLLASRYMLLTRRPAEGSTPLTTAFQLGLYRDGTVLNMTDKREMEVRRRAWAMLYHLDRTISLLVGRPASISDAHTDARPPANLDDEEIESGDFDPAGHPMTKPTQYTYVIVRHKLAEIMGRIAYHTFTIQMPDYQTVLALDKELLAWRDSLPSFLAMINPDTSLDASHPYLFVQRHLLACEWYYTRITLNRPYLLRRKPQDGRYAYSRNAAIESARADLLSRRAFMLEKGDLIINSGGYRVLNSYMVLGVTIKLDPDSPQADELRHLLNVVSGRARDEQGRLSEPIVKEELAIVEFLTAKNPTKAAPSTANGAAQKQRAANGEGSDENTPVDLLLGLAKTNSGRRAAEEERRQLRLQQRREMEEQRMAQRRSMSSASNGNNQMSSASPWGYVAPQMPGLDVHQPFGSQNASGMRRVPRPLQPPTGAKREGSDSGKDSLGNWSPENPFSFESARASPGFNATGPNIIPSPHGQFQNVSSQNNNANQISGLSSYTDMSLPITSPNDQLTTTLQQNSAELFGSNGAEFGTAVGDGFDFTNLGVPGPGNMDMGAFNPFTITQTGGNDEGSGSEPGPDDETTFLNFILHKFANNSGEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTA1</accession>
    <name>K1VTA1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000356">
        <property type="protein sequence ID" value="EKC99917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTA1"/>
    <dbReference type="HOGENOM" id="CLU_2741843_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTA1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="71" mass="8152" checksum="57A4BA7330E849C8" modified="2012-11-28" version="1">MNSPKSVAYGWAGENEKRWKDQRARGLRSPEHQDWKDKLAAAEEEMRAEIQANAAKARAAKEEQQQNNRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTC5</accession>
    <name>K1VTC5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein DUF6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTC5"/>
    <dbReference type="STRING" id="1220162.K1VTC5"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_4_1_1"/>
    <dbReference type="InParanoid" id="K1VTC5"/>
    <dbReference type="OMA" id="QIIFIRM"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="44750" checksum="E7E47E838280E5B7" modified="2012-11-28" version="1">MKLPDLPESLSARRMRSHFPPTVLALYDNNYGLFLIATSMLFFAAMSLSVKYLMETTGMSTLTLILVRMGITGMCCWAVLWGVQRDPHPILGPPDIRRLLLLRGLCGFSGLLCAYQAFRYLSVSDTVTIQFLQPTVTGLLGWLLLKEPFTLREATAGIVSLCGVVLISRPPFIFGHGWGGHDTPIEEAVPPTTGVEHDRVLGATWAIIGVFFSSGASESVRGPGSEIPVEQSSGRGRGILFTPGQHSWPKGTYDFALIILIGVFGFIAQALLTFGLQREKAGRAGLASYMQILFAVVLELFVFHTIPSFLSFVGMSIILSAAAWVAMDTLKTAPPPSVEDPESAPISRTPSPSNTGVKTVRGELYSYSSVPTSDPAVATGQTLRLPSPAPEARQRADSSASLASATGSVTGSLNGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTL2</accession>
    <name>K1VTL2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTL2"/>
    <dbReference type="HOGENOM" id="CLU_774310_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTL2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="40325" checksum="C92EBB9B0AD04D2B" modified="2012-11-28" version="1">MMRRGWTKKLLADRAAGKEQQGPTVIPISQMPDEQRTAYLAEISADERPQRWHDACENALLAQPVVAPANTVQPYPGQPSEPGAVGCECFKVLPPQKDIVEHLHLHHVLPKQVDEALEMWGQIHELKTCPWQGCGADVGEAKEFAAHLASKHEGDHRCMVPTAYMTACNERATAEHLEYHHGLISYEESNEERKSHCGQHLVVYCTVCFRFVRGRMLLTDHMDSHIDEVVTLIKSDDRCLGKGGILSAWRREVFCPKCVHDTTLDPEERLKGYEDLVGHLSTHLIFHKPDTILQCFFPSCSATSTPLDLADHISNHHRIRMFQEGLDGIHGDPGKLMLPTDDPNIQLQMDLHVLPICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTL8</accession>
    <name>K1VTL8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTL8"/>
    <dbReference type="HOGENOM" id="CLU_638077_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTL8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="517" mass="55150" checksum="EBC2685A1A53D4EE" modified="2012-11-28" version="1">MEHDRISRQQRRAIGFGPARLGPPPSSTFEVHSTAHVENIAADNNINDDSGTATKHDSKMHPPDKGKGKRVAPISSGAFSFSLGAGPSKKPKGDEGNNNKAAASEHVGASKPRSPVVSKTLRQPSKTHAQTAVTTPRRPERPLDSSTAKPSPRLQAMPPPMSLTLTPKLQKTDVTQTTPTSARRAPPTFSLAEASPKGLGSPQIARTRPLNPVSGSPFRLSGITAQKAPKPDVTAASTSVAHRRNRWGGVSAKAEERTQVRRRMQDAPVLLQVTRTMRAPSPSAALAHCRVLRWAAGTGAHAADEDVMVVFKSLPQECPRIGRALERIDENTRAAVWFPTSELELRAQRGPDSGTSDGRERDGQERQDAPDGQDATVCVVAHESSESDKHPQEPQDGQGHAPDIRRADRADRADRPLPVLAFGAWGARMRSLAVCTTPAKLSGVLNRDSTDALFGGSSCLTHFTLMSPHTAETLQPSSSPGPPSFGPASCRLDRLVLHPLSCCLALEHGSEAPGPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTQ9</accession>
    <name>K1VTQ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTQ9"/>
    <dbReference type="STRING" id="1220162.K1VTQ9"/>
    <dbReference type="eggNOG" id="KOG2372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_593145_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTQ9"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="294"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="432" mass="46557" checksum="BCB18D74A013FEA8" modified="2012-11-28" version="1">MSSQQQFNPSRSPTAKSPQGHHHSSSSDFGDFHSAPVSKPGDIFFDPPASCSTRGLHLTDTDLLGSFEDVDPMPTNRPAPPTSRAPPLLDFGRDLLTEEPESTTASMVSPSDSRNLSHRTSKSSLESSPSRSRFLINAPFPGPSSPPRVSESGSEILFHAPSSMDEAATQFRRLRRLSNDDFNRTKSAPHPGNGVPHTQHSLLDALATTKVASRWKRSVLNPLRSEPEPPSKTAVPIDVNHSSPFASVDQIAGRNYVAPSGAPGFRPVSESSHKANDEDEWASTTLEGRRDTTEPVLSIQQAHFAHSCLPAKGCQTRGACFHGASLSTLYRLVEVYARTHRTTGNLLAVKDSEGHVFGVFLNEPILKREGTYYGSGESGTSYGLLLDSTFSRNSSATSPAFQNEVLCGGSGSDLTEKAQPFDCLGLEVWATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTS8</accession>
    <name>K1VTS8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin-specific chaperone C N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD02972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTS8"/>
    <dbReference type="STRING" id="1220162.K1VTS8"/>
    <dbReference type="HOGENOM" id="CLU_1134237_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTS8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26257" checksum="22EECF5365CC2EA3" modified="2012-11-28" version="1">MTSTSISAEFQPEFARLKSDVEAAISASSPASAAQSLLTLRQAFISAHAQLPGYDQKKYEREIRDLEARMDASRASKPKARGGHRSSPIPIRLRARYNPHALKSGPLPHRPPFLPPAQSPSRPSLVVSPPPALLARGRASTPPGILRALSPELRPSYPVIEGCRSIYTMPAPFREEEVQVGGEGGEGGQGQGEGRWDKVQDFDSPTGASSNWRTLTSDEQATVKDGIRTSVESGSVEPALASIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTZ1</accession>
    <name>K1VTZ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTZ1"/>
    <dbReference type="HOGENOM" id="CLU_365704_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTZ1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="763" mass="83239" checksum="E937D5846CF7F16A" modified="2012-11-28" version="1">MLPPNPDLAPRPLSGQRGRFGAPTTPGNGGRGGDSVRVHGGGGNPAPGTQHGYANDQQQGYINAGYHARGGHAGQAGNKGGWGHGYDRGHTHRGFSNHRGRGGSFRGGPPPSPTTRRDIPASNSTVTPGYSASAPPSLHGSRAPSRAEPHAPPPAPSRPGTADPTMVQWFQTAPSRPASAAPRTQVEPIETIEWSDMPDSREPSRAPSRAASHAGSAPGTVLFSTQGQRGLGSGGLSTAGYTVATATPPSLQGSAWNAPLRFDQGPRAAPRGRGDYGRGRGGRFSFQDIDQPGFYNRSSNVNRFDNTPNYSYPNYRGRGRGRGRGKLWIPRNPLTPEALGSLKDDSYAATGTLGNWARQTRPLSPPLEEEDSRPSTPFSLPPTPQDSPHAPSTAQPHLGAKLDASAYPHIFDQIFALTPHAGLLVLRLVNRAVKDRVDARLFRHVLLCTPERASGLVLLSPWGDRLPFVPWDLDPAPAPDHRDYDDPIEEYFGPLKEEGDDTAALDAAYFSRMAQLRHVRVLDFYSTKSRIKQLALGLKDVQLVRSKPDWHWERHPRKWRVQAPTFVSYLNLVQSWAEFDDAGGWGLEFADGQLASPFAFLIPRAQHAVLHLHYDSERGLLPTRFRCLPDLESLTLVWHNAAGGEADASQLVEIVQGLPMLNLTLVGLEPRNMLQAGDWTAPIYTRLDQLGTPNFRHVRIMARRAWEEGADPLIGQDALTYTQPYIPVNQDFGWDSDDEAFARKYYRPEPEGVAEESDVESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTZ8</accession>
    <name>K1VTZ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTZ8"/>
    <dbReference type="HOGENOM" id="CLU_2591479_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTZ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="80" mass="9057" checksum="F996EF6F2592631E" modified="2012-11-28" version="1">MIMSFLSRSLSRRSSTSSTSSGSSDQAQSRVEDGFNPSPAMYWHAPCATAPFYVSQREARKIERNYQKMLQKGIVEYART</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUS2</accession>
    <name>K1VUS2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">A1Q2_01470</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUS2"/>
    <dbReference type="STRING" id="1220162.K1VUS2"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_0_2_1"/>
    <dbReference type="InParanoid" id="K1VUS2"/>
    <dbReference type="OMA" id="SVFIGAW"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000002">
        <property type="entry name" value="Histidinol dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="203"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EKD04251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="820" mass="87157" checksum="CDFFC1100B2FC80E" modified="2012-11-28" version="1">MTRPVFVPLVDPTANALIPSLALIGPLLIPTSLVDAVRPSLPPTASYIVEASAAKPDTDLVALLNNGAKALVVSQAQLDNLSDVPKERLIVKVAESELANAAQLPAGGLYVSASKVVTPKEIGFKGPVFLQTEVSAANAVETIKAAGDATVVLPTALLTEGASTSSHVGIADAFLAPVISDRPDGLFPTIVASSTHSSRPLGMVYSSRESVAEAIKTQKGVYQSRKHGLWRKGETSGSVQDLVKIDLDCDTDSLVFEVVQHGTGFCHLGTPTCFGQWSGLAKLEDTLQSRFVSAPEGSYTKRLFTDEKLLRAKIMEEAEELCDANTKEEVAFEAADLIYFALTRAVSKGVSLKDIELALDAKSLKVTRRKGDAKPKWEEKVKPAAAAAPAPAPAAETAEDKPIRMRTTVLKDVPKEERPQLLVRPVLNSLAMIDKVKPIVERVQKEGDAGLKAMTKQFDKADLESNVQLPPFATPSEAELPADVRAAIDQAYSNVKEFHAAQLDAAPLRVETMPGVVCSRFARPIQRVGVYVAGCKEIVLATPPRPDGSISPEVLYVAKLVGVTCILKAGGAQAVSAMAYGTKEVPKVDKIFGPGNQWVTAAKMLVQNDTDALVSIDMPAGPSEVLVIADETANPVFVASDLLSQAEHGVDSQVVLVGINLTAEKLSAIEAEVDKQARALPRVKIAREAIGKSLIVLVDTQDEAMEFSNEYAPEHLILHLKDAPGAVAQVENAGSVFVGAFSPESCGDYASGTNHTLPTNGYARQFSGVNTLSFQKHITSQEVTADGLRKLGPVVVTLAEREGLEAHANAVRVRLAELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV12</accession>
    <name>K1VV12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV12"/>
    <dbReference type="HOGENOM" id="CLU_364545_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV12"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="766" mass="83827" checksum="57F92FDB962C95BF" modified="2012-11-28" version="1">MPKQCSRPPSATHRHLDLSDQPSSLTLGSTLQPRTRQAAPRTLHPVHQPVPAVKDIKPAHHEDTTEKRTRDGVERVASRAAAPPAKRSRAVADEHSAPIGVVPRGNVGSSTSATVHTPQGNTNPFSPPAAPRKQNPRVAIFRSSPKTPAPMSTAKSAEPSSSPVSKIRRAFSMPQGLRSSASGKQPPTAEDVRTAIMGLTHDFGRLADAQKTDGGWTESSRIFHEMLGGRKGVSRQSIGNMTFHSDEQFTARKGELVFLKGDSSKDIRAQIHERLGPTHESVSNISLPLPVAQFDKHPELLKRRIWVRVSDESSSDITTWSFAPQHVVVFIEVEGDASFNFAYRQHDLDTRSMSKRAVFCSWLSSCQETYRAAEAGPSWSSPPRLSGHKPAAIAVPPRIDIEALPLTRLGGLCESFLNLVGTMNDLVKPVNLEGPLDPVDVRNSHGVDRGGHCRRTPRSRDRARSLGPHRGASGNAEQFGLGALWLASSPQDLDEADEYQEDFAATGVIENDQDTTEVVNKEGKADNEEHCEDEPPEENDERGVGNEDERVAEEENDSADETASVDNAEGTGPSTAPVPRQFRIPDLSLPAPHVRCLIEILNSLIDGTCEVNRKDALVRWKFDFEVLDTIADFANLKHTPSAVSLPVPRSKMTAAFKGGLTVGVLLTDLEGGNLWNAAPLRADKIRVTIKSVQTDKIYFTYIESDLPSTAYNQWWFFLMFLDVAARYKADEEGLQKVRKRAESKAAGQALARALPYKNGKLKGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVT8</accession>
    <name>K1VVT8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fructosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000213">
        <property type="protein sequence ID" value="EKD04661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVT8"/>
    <dbReference type="STRING" id="1220162.K1VVT8"/>
    <dbReference type="eggNOG" id="ENOG502R5N9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708207_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVT8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="4">
        <location>
            <begin position="79"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="390" mass="42031" checksum="94FE25E2FEEC8F52" modified="2012-11-28" version="1">MPISTEQISAPPTRKWCTGSDDWLVGGNVEALPENALFGKWRPKAHIISPNSWMNDVCDTQGQRRAALPCVVPVSPWTWGPPSQASCVSPDGVHWRDIGAGPLNPTVLAPDAANGGPLAIFDGTVVPGVTYRIFTAVNHLPIGWTLPFVPTSEVQNLAWTTDQGQSWNVFEGNPVIGSPSREILDTLAGVQGDYNVSSDPSVVFTDPRAIYMAVAGGNRKMGSPALMLYRNTAGSIANWEDLGVLFMPTGGIKASPWASNVGHNFELFVKKVEGVVPHSDDEGHWMGVDGTYVTLGTRLAAELVEAFTTKDKLIFTGTNVANGISPQPQCQQYYVDVGCCFTNRKGTFSLDVLATPDGAEYTRIIYDRGAASRPNQVEHDSGAGRPRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW08</accession>
    <name>K1VW08_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW08"/>
    <dbReference type="STRING" id="1220162.K1VW08"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007645_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW08"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="38"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133714" checksum="96AB6918C530A907" modified="2012-11-28" version="1">MVAAGAAGAIGVTDGLSSILAGRDIRWYKGHYLRLTMICLLIIITSMTNGYDGSMMNGLQSVKNWQEYFNSPSGTTLSLFNAIQNIGTIAGLPFAPYVSDWFGRRFAIAFGCCLMLLGTALQTACQNFGMFIAARGIIGFGLSFSCLASPVLITEIAFPTHRAPLTSMYNSTWYLGSIVAAWTTFGTFRIQNTWSWRIPSLLQGLPSILQLALIWTIPESPRWLVDHGKVEKAANVIAKYHCNGDREDPLVAFELAEIEESIRIEKENQTGWIDIFKGRGNLRRLRIIIAIAFFSQWSGNGLVSYYLVLVLNGIGIRSQGHQTLINGILQVYNLFWAYAGALAVDRLGRRFLFLTSTAGMCLSFVCWTICSAIFRQSSTVFDQECMTKYPTSYEDNCTALNANHAAGNGVLAFIFLFYAFYDIAMSPLLVSYTVEIVPFKNRSKTLMLMQLSVSAALVFNQYANPVALEALNWKYYIIYCVVLAFEFVYCYLFVVETRGKHGPLPLEEIAAIFDSPGAAWGFKKREFIDEPIDNESHPNALDIDDKKGLDHERVSDVSKTQQGMQKMHPTLASRTPAIRRRTVRQAAIGAPSAIRRVSPEPTSPPTIAQQPSEVLSRCRRKRRAPATTAGNAKFALALKQQQAAAAAAQNGGTENGFAHDPRGPGPVRNSFSRTSYGPYDRYDEYESVQGTPRSGYAALGTPRSPYGAPNPGALRGDIGGLSWLDSMIDGSLFPDLGGFEMLGPGTTQFGNEQAQLLSLESPENLASGAGSATSANGAAQRAVRDRSPQIEDVTSWANISHYISLYLAYLWPLLPLVHRPTFAENLVSRLDLRDTDFRALLLSIVAFTISQLPTTRLVTEQFDVEGLKRLQRKCHRTSQALQKGYTGQVSLTQICIIIFIGLQHTAAARLGQAVQLAFCLGLHSDARTEALGLDPVEVQLRRRVFWQLYASDKTRAIPGNPMLINDFQGVCSYPEAVDDDFITSQGMFPQPSSKTSLLVGFVAVSKLFRVMSECFFHHRCLQSGLKTINSQWPQLAEERIHKLLNELPLSIQDPNTASANRAIFATQRANILITTAIVKFALYDLRSALAEDERGERGGDRSEPDSNDSNETRDTRETRDRERERQVIAREIYNLLISIPVEDLASNGESVRSKVIHIACALVNTNTSEDNTLIKDWCDMFSAISFVQMPVPLLDSRANTPPPAAEPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWA6</accession>
    <name>K1VWA6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWA6"/>
    <dbReference type="STRING" id="1220162.K1VWA6"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="InParanoid" id="K1VWA6"/>
    <dbReference type="OMA" id="FIFFIAN"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="121"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="594" mass="63946" checksum="F02A247721EDE945" modified="2012-11-28" version="1">MTAPSPQSPIHKGDTEVTATFDRVDTVGTTTSFATAHSQDSTDTRKHGSTEKLSPAPPAPQEDESAREPEPDAAYHSEEPVIRDEKAPQDGGQAEAQLARTVTGGSGRPYSAFPKRTKWLIAGLGGVAAVFSPISSNIFVPAIPALASAFHRSEQDISLAVTTYLVFQAVTPSFFGSASDTFGRRPIFLLVMAIYIGANIGLALCPTSEYWLLLFLRAVQATGGSGVVSIGAGAISDVALPREKGKKSSAMLGPSFGPLLGGILAQTLGWRSIFWFLTIATCCVMLPFLFLYPETLRSLVGDGSLPPPTICSSPIAIWQEHQRKKKARAEIDAGEGAEVEEEVEQELATRAPRKKYNPLTAFQCLLVPEVLLVFVFVSLPYLEFYCVLVVFSTALKDNYGLSELHIGLCYLPGGAGTIASALVNGQLLDRVYRREEARVGGDFRKCPTTFRLERTRLWCMYPFALLFIVACIGLGWCLQAKAHLAAVLVMQFFVGFGTGTTSMATIYGQDVLPGKGGAVSASLNLVRCAFGAVGSAVIQIVYGRLGAGWTFVLFSGICLAGFPLAFIAEKYAGGWREKRAEKRAAGTLWKWMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWJ9</accession>
    <name>K1VWJ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intracellular protein transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWJ9"/>
    <dbReference type="STRING" id="1220162.K1VWJ9"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025813_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWJ9"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="61"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="630" mass="68461" checksum="288DDE56EF278D05" modified="2012-11-28" version="1">MSFWTILDFGYPQNSEIDTLKMYITTEGVKSEMAVREDSSRITIQATGATSWRRADVKYRKNEAFVDVIETVNLLMSKDGSTLRADVDGQILMRAYLSGMPECKFGLNDKLVLDKKGNDNVAKGDSAVELDDCQFHQCVRLGKFDSDRSISFIPPDGEFELMKYRCTSNISLPFKLQTHVIEPTKTRVEYTIHLKASFDSKLQANNVVLKIPTPLSTTKVDSKVGIGKAKYAPGENVIIWKIPKIQGQQECTLTAEAELAHTTTRQAWSRPPIEIDFSGELGSAACQLTFSRHVHRLRTARPVPEGVREVGSCSGRGASVGLLVLGGPAARRTGEILVRLEKTLLLPLEADGALTSLVELASAGRLVSANLGPSLLILHPDEREDDKPPVSHVRAAGPDGADIVPPDERLRQLPEPAVSVMSGFRGTALQFPNVACDAVRAWPVSTFGGLGTHAVHEILPLDAVGGPTGQASAHDEEQHGRRRRERLQGETLSLREEVPGREPADGKAGQGAEDDRARRVGDANTAKEDHALESLSQHRDEGKTEEDETSRSAGAHLALLPGTRDVGDARVALDGTDELEAPLCLRHRQAKEGEAHHEDDERGNAAKNTLPEILSVLPEVVGEVVELGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWV2</accession>
    <name>K1VWV2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWV2"/>
    <dbReference type="eggNOG" id="ENOG502SGNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_748063_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWV2"/>
    <dbReference type="OMA" id="KWWHALC"/>
    <dbReference type="OrthoDB" id="2574168at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="326" mass="34498" checksum="4BA2402E9B956B29" modified="2012-11-28" version="1">MPSVPVINTAGIHSTKDYVPLDDQLEEVTGSPTTAVNGSVVYSKPLSHGHGSRHGSGSAGGSRWVEEEDGDIGAVRYKGKERAWDESSSPAQSPATADFSHSYPPLSQEEEEERRVQANLAKFTARETARRKAARASRVFPSQTDSGRSSASSSTTSLPRSRLSSIQGTVKRSSVFGNLLHKGKGSRSSSTSSSQSHDLSLPSTSGANAQTAYPNPYDSPAESDPLRSPTSAAASPTDASFKPSMKKSSPFADPSSAQSPVQSPTTEGNVGYQGQHWRGGAAVTEETVAPPKKEKWWHALCAWGNDLDGGHGNRSSNQAGRTNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX47</accession>
    <name>K1VX47_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="AMBO01000236">
        <property type="protein sequence ID" value="EKD04052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX47"/>
    <dbReference type="FunCoup" id="K1VX47">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX47"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX47"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="378" mass="41352" checksum="B61B70C2442C0CC0" modified="2012-11-28" version="1">MVLNIPLMQQAGVVTGKNLRALMADAKKNKYAIPAINVTSSSTVNAALEGARDNKAPIILQLSQGGSAFFGGKGLDNADQKASIAGAIAAAHYIRAIAPAYGIAVQRSSYPGYCEQADSSPVVLHTDHCAKKLLPWFDGMLAEDEKYFKEHGEPLFSSHMLDLSEESKEDNIALCVKYFERMAKIDQWLEMEIGITGGEEDGVDNTGVDNASLYTQPEDVFDVYKALNAISPDFSIAAAFGNVHGVYKVGNVVLSPQLLEKHQRYAEQQLGQPEGSKPIYLVFHGGSGSTKDEIATAVKNGVVKMNVDTDTQWAYLQGIRDFILKKQDYLKTQVGNPEGESKPNKKYYDPRVWVREGEKTMAHRVAEACTDLGDINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX66</accession>
    <name>K1VX66_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX66"/>
    <dbReference type="HOGENOM" id="CLU_1023743_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX66"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="28938" checksum="73790D9B1D10590E" modified="2012-11-28" version="1">MNRNCTDGNGISRSPSLEPSLPDNSPTLPRSPAVTDSADQLANQLERARLSTPPPSAPVPIALPSPVGSTITNFEEEGHRRASRPGTPCRSCGDRYLCPTCGLCGRCGREYAPSPEPEPTPELTPEDSNASTFSGLWSMSSFGNGGVQPRRMLEVTVRGRDVINAAVAGSALGRQFMLSANGVNLLSVDQLRRVGDYFAGVWPNSSDEVPAGTHYSCNGQTAIFRFEIEERDLTGGTAVGYHMAQWAQAALGGMWEHSVAVIQSSEDRSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXU7</accession>
    <name>K1VXU7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXU7"/>
    <dbReference type="HOGENOM" id="CLU_928094_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXU7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="331" mass="37304" checksum="9D8FB0E8A07C6DD7" modified="2012-11-28" version="1">MRRLDWKFYPHLFDTILTHVLEDASAEAYVVHGIPAPTAGDSLLGALRLTNHAIRDAIDRRIDNHAVALLQPRVLYTFVGKVKLYKNPETVARARVLDVHPGSASKVAPPHRYRSKFKFSGAKYARVFSESCEEVLDRIIGHNSQDLTVIYPVLEFQSYRERRIGSTQIKVTRTITLLPVNLGSRNQSRTWVKPKSEGDAEHLAVFLAAPGADTLTQSDDIYEYPMAQFRHGLMTLAYDMISSARKLAPGRVATVGLLESIRASAPQGSNCAEWYTSFEDLAFGNSSLMGALHAHRYSWEEWRDQLSQEEWSLIESIPGVCWDTYTVHSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY31</accession>
    <name>K1VY31_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY31"/>
    <dbReference type="FunCoup" id="K1VY31">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VY31"/>
    <dbReference type="MEROPS" id="M76.A02"/>
    <dbReference type="eggNOG" id="KOG3314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079125_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY31"/>
    <dbReference type="OMA" id="RLAGCEF"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="219" mass="24846" checksum="DBD2A4226C4BD6BF" modified="2012-11-28" version="1">MSATEAGNSADAGSSSQSTPNEVPAGFERWRQSLARFTGMGLSDEERAERAKYDEQVKLATDWDRCEKWKSELMTRSPMIIFMLKQLRLAGCEFPASAMQCHPCDETRVGGFSPEHGILMCQNRFMNKKHMEDTLAHEMIHAFDHCRFKVDWSNLRHHACSEHPLCDGQEAAEKAVNEVWESCFRDTRPFDEVSARRGRHEGPIEGWRLVVGGPAEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYA2</accession>
    <name>K1VYA2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYA2"/>
    <dbReference type="STRING" id="1220162.K1VYA2"/>
    <dbReference type="eggNOG" id="ENOG502S0ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500771_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYA2"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="176"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="544" mass="59839" checksum="2CE156CB330B05A7" modified="2012-11-28" version="1">MPRIPSREEPYHSVAKCNRHWKTKREFVTKAANKASHVDGSHYLLVCVTPKGNIEVHASEHFYDDTNQQRTDGVINWDVLRKRSSAIQARNVERWQEVERQEKRFGVEGEGEDEDNDDENEDGEVSVSDLGVPGASGSDTSSVVAMGGAPVVSSFPTSSKSSPARPVSSVTLRPDTLEQEYSMRFEHLGQGVCANVLKAWIKVVEPKKQTKFPYKDKKGNEGKPPPWWPTGMRHIEPDHLHKDERPRLLSSIIMQASKARSEGSGKIATSPDARELTISRLHFATAEIASAIPPRQHYELRQIYLIAKEVRKAVEDRMRECKSKGFAFDETVPAWSEITVEFFEKSPSASSNSGKRSFDNADYDLSRMPLANKENLDYGSRPIKRGKHELQVSPLGSHQNIYAPVHSYQIEQQQPPTPSTSPYAGWNGVGAITVPTTAANASPSSLSSTSATYYRPFVPDMAYGTPTTTASTPAASAYQYATPNSTTGAATYGYQTVAYPPAPSSYGSSTPPAASYPTPTATQSYTYPSAYEGQSFVSELTLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYR2</accession>
    <name>K1VYR2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYR2"/>
    <dbReference type="STRING" id="1220162.K1VYR2"/>
    <dbReference type="eggNOG" id="KOG2687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351320_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYR2"/>
    <dbReference type="OMA" id="EDEMAYR"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="608"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="331"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="801" mass="86713" checksum="42549F95AADD9B94" modified="2012-11-28" version="1">MANLSSVAAAFTAAQNGNATPKAVSHRALSPMPEPSRALSPPERILHDNRALSPVTYHLHPPPEDLDLLNASGDYSSFSSLGNSSGDYSYAKEDMLVNQQRSATSRRQPRRNKALEDEMAYRPAEDEGVASDSSGAGGEGVVRSGALDGRSATRGKRKTKGEGYLGDGLGIRPTMTRPTVRRGTRRELDITEEEQSINMSHSPSVMSRRSQRLSVSPAPINHPFTSPGVAYQDPQMGRASRGPSAGRTAATNVTGWVAGSLAYLVKLGSSFILFIVNLPRNLMRKARRGGNGALAVAGLVLCLGLLLAARELSGNLFKSTYRSPVAPPSNIDELIARLTSLETALARASSTASEDLTAAQEAQRVLMKRIHELEARQHQEDANGMETRAGVVDVQDSVKQLKVEVNELQSRVSKHDQKFANVDSEIEAVKGKIATVEEEVRRQLSEGHLRDIMLHIMPAKTPMDDGNIPPSVWAALKKVFVGSDAVDEKIRKHLAGIQSPDSKWALEHHQEELNKWLLKAGHSLGYDKAAIINGIEGEVHALQKELQEIRRDARNVNSGKPVAQPAVTFKSSKGEDVTQALHAIVDAALLKYSKDMLAMADYALLSAGARVIPAGTSETLVLKRPSVVGKVLRGDRAITGRPPTTALETDTAVGSCWPFEGSTGTLGISLARPVNVKAVTVEHAAKELALDWASVEGEENQDKVKQWFEQREADGWVEDEGAAFKETPDRIRLSRFTYDPMGPSPVQTFPVVPEIIKMGIPVSDVVFAFNSNWGGNLTCIYRATVLVVANEQVRVHGEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYR3</accession>
    <name>K1VYR3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000217">
        <property type="protein sequence ID" value="EKD04647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYR3"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="K1VYR3"/>
    <dbReference type="OMA" id="VWQLIAT"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="519" mass="55336" checksum="C9323C1C28456835" modified="2012-11-28" version="1">MSTTTIELATLERGVHGSGDPTPGPSIPPTPARSLNNSPDHSRRTSRTSFDIPSRPPSAVTTIPKANYEYEYPPPSAVPSAHSRRPSEEGIGAAELDNDTATAALPPVDGGKRAWTFLAAATFIETTVWGLPYTHAHAGGYVADGAHVHVDRAAWTAFPHYSRQFQIIGLTVSTAALIGSAFVTQASHLVITFGVLYPFAGALYLPCATLLYEWFHQKRGLANGILFSGTGVGGTVLPIVISALLNGVGYKATMLALGIAFGVSNLVAMVFIKRRVPLPPRSGRLRDKLRGLRPGRPNRRLHDGHSGRHTGGLRGKWNVDLGITRTWAFWCGLLVLLLTSMGNFNPTLWIPTFADNVHAHPDGTAMVSIMNAASVPGNLLLGWISDRASARVTIAINCLVASVIVLTLWGFGTSSSLLILFSIFWGFSALSFVSLWGKMITRICKDRPSWISLIFSMFAVLRGVGNLTSGPISSKLLQTQAFKGAAGAYGKTNFGAVLIYTAATIFGGGAIGIFFPGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ04</accession>
    <name>K1VZ04_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ04"/>
    <dbReference type="FunCoup" id="K1VZ04">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZ04"/>
    <dbReference type="eggNOG" id="KOG3064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050888_0_1_1"/>
    <dbReference type="InParanoid" id="K1VZ04"/>
    <dbReference type="OMA" id="CPLANTK"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="329" mass="38331" checksum="8A5BE86AE4362511" modified="2012-11-28" version="1">MQVINQQFCSYKVKTVTQNFCRNEYNLTGFCSRQSCPLANSRYATVREKEGVLYLYVKTIERAHSPANMWERIKLSSNYTKALEQIDKELIYWPNFITHKCKQRLTKITQYLIKMRRLSMTQQPKLVGIKKKLERREATRERKALAAAKLEKSIEAELLERLRSKAYGDAPLNVNEDVWRQVLEMDKGKGKLEDMEEDDSLLDEEEWEGGEREFVEDDESDDDIEDYSGSEFDEFDSEAESDDDEGQEFPSDLEVSDEEDEEDDDEEDGEGDEGAEAKKPAPKPPKKPEAGAKRKATKDPKRANKRRPHVNVEYEMETEPLSREMLNNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZB5</accession>
    <name>K1VZB5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZB5"/>
    <dbReference type="eggNOG" id="ENOG502QTH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_937460_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZB5"/>
    <dbReference type="OMA" id="NTHEDAC"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="297" mass="32967" checksum="498FA693FA08C98C" modified="2012-11-28" version="1">MKQLELAIDKYRQKDPTLCIEIHMHPFQLNGLITETPIKRQDFGERKFGKARWDAINASLVDKFKSVGIDFQTDSYMSSSHLAHRLAALCADKKPEEEVSLAMDFYDMHHVQGIHCSDKEALARIAVKHGLFNTEQEAVNWLNSSEYDLQVKKCYQKAQQNGITGVPFFVFQDKYAASGAMGVDEFVQVSLSHSRASGWSVDRAALNICPAEGIRFVRANRSHESGSRRPSTAARSCAKLTLQILSEVSRREKSLSPPPLQVSGDTCPVNTHEDACHADDACHVEHAQTQPAAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZD3</accession>
    <name>K1VZD3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZD3"/>
    <dbReference type="STRING" id="1220162.K1VZD3"/>
    <dbReference type="eggNOG" id="ENOG502S7FU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034578_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZD3"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48689" checksum="6EE6C7520B1CE583" modified="2012-11-28" version="1">MAPDGVIISVGNPGWTMDDLSANDFSLALWEKTAWTRMSVFAAQMLRDSSVMDADTLEQNGRYHQRVFHLNPGLVASETFPYGQLPFLIGIARRIAIMTPAAVEPDDYADVPVFVAMFSEEAERIGQGRLLDKNLAHVDPGKWAQDEVHRAEVWEFMERAAGASGPELTSRGQPSVVVAVLRPPSAYPNADVVVDLSAAPGYGETPELGARIRDLCELVTYSLKLTAGSKLPPKAQIYIDAVDILAEDHTPYAVLRSLRSILAAVNASKPGRLILSLPRDSRFLPLVTPASLSPGLILITPHNPRAVEAMAQRLLLTPEDPRFFSLLDRFSGDTLALAGSGLEVGEPSSYAVQVLIRKATGGAKAIVRAVEGYTAGKPVPLEQVASFKLLAEEKRTTTHADLNLPFNLSLTDRQKSERGAVPLPYAHEGEGADLGMGMDWSDDEEDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0G4</accession>
    <name>K1W0G4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0G4"/>
    <dbReference type="HOGENOM" id="CLU_2361227_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0G4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="96" mass="10602" checksum="ED486E4EFEE34E23" modified="2012-11-28" version="1">MFEITSVPANALLLYMPMRSVGRHPKTSNIADCRAIPAALRQKEEWAGIGHKSSAAMAGTKASLFHSLRQFFRFRRARSASLLPLALVTAHQPTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2G9</accession>
    <name>K1W2G9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2G9"/>
    <dbReference type="STRING" id="1220162.K1W2G9"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="K1W2G9"/>
    <dbReference type="OMA" id="WIPNDAR"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="69"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="612" mass="67081" checksum="467055CB225777E9" modified="2012-11-28" version="1">MSESKRDLNASSLTVADGGDHTLRRKPWLRKTTPWADIVGHQYKGAGTEADPYVITWLPDDPENPMNFGNGYKWGMTMLVTMGSSMLSAAIKSIRMDFPGHNSMLYIMITGIYVLGFVVGPLLWAPMSEIYGRRLLFVLTYIPFTAFNAACCGAQDMNTLLVLRFFAGTFGSSTMTNSGGTIADMFSPAQRGAAMGIFAMMPMLGPAIGPVGGGFLSDAEGWKWVAGLIAIFSGVLTTAGTLFLPETYEPVLLRQRAKRLQKNTGRVYRYEQDVKKEFDARKMFREQLKVPYKLLFTEPIVAIASLYLAVVYAIMYMEFTAFPIIFQQYRGWSSGVSALAFIGITLGSFFGLVFLGVYVNPRYAKAHEEKGYLPPEARLPAATVGSILLPVGLFIFAWTCVPVRIHWIGAISSTLPIGAGIVLLMLGVSVYLVDTYLLLSASVMAAATVTRSILGVVFPLFTVDMYTAMGPNWAGTFVALLACLFIPCPILMYIYGRRIRRWTKPGREADDLGRAIAQKHQAERARAAASGEALPKDSEAELDLRNEPEYFTPEDAHKDRAAEMALEEGSIGEEEPETPKVAGGMSASSSTTAFTQPQEGRRVSAIPTLDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3B1</accession>
    <name>K1W3B1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000255">
        <property type="protein sequence ID" value="EKD03378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3B1"/>
    <dbReference type="STRING" id="1220162.K1W3B1"/>
    <dbReference type="eggNOG" id="KOG2911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021165_1_0_1"/>
    <dbReference type="InParanoid" id="K1W3B1"/>
    <dbReference type="OMA" id="VEDRPMQ"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="547" mass="58236" checksum="DB0B92E863591443" modified="2012-11-28" version="1">MPPLSFLRDSPVPDPSPERLAALYAFTRAQATSNPDGYASNVAWWGQVLAAGLQEGTLGDADGSGSAASSRAGSAFKPDLASASSKGPRDTLVLTVDDGLLSRVTQDGRRPKGLGGVVESLASERSLMRLAAYNALTSGVEQGPGLARRALGAGLGLIGGLVWGKGAPAPEETCWKTAQGRWVHVGNVKAAATSFAAHLAANPPLHHSDCLFSRATFLETFATTAPEAPLTKRDVDVLLLYLQRDVGSVQIDGDVASPLGLGEGPITEADRGTLSVKSTLAAVEAQIEDIESQSAKTMDKVRSSLKAGQKAGAAAYLKSKKGLDDVLSKRIATGEQLRSVLRSIDDAKSNAEIMSAYELSTSSLASALADPRLSPDRIANTTDALADVLADSKEISDAIEIGGAQARQAAGAPEFDEDELAAELDVLVLEEKTAQKERAEREAREAVARKEAEGKAAAARKVAEEKQKVEEKEKKEREERERAARVAAAQQAIKSSEKVAEKTEGSKMTEEEEWAQRHADAQQRQREEKERAERERLEKESQRLPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3H2</accession>
    <name>K1W3H2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3H2"/>
    <dbReference type="FunCoup" id="K1W3H2">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W3H2"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_1_2_1"/>
    <dbReference type="InParanoid" id="K1W3H2"/>
    <dbReference type="OMA" id="MELWSAN"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="204"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="386" mass="42649" checksum="4227A45AB0D6C635" modified="2012-11-28" version="1">MRGILAQPVRLARVVRPAPRAVLQPSVRCAPRTPSVLSHLPKRPFSTSGPKRSRYDRWDPYGGQGQPGGGRQNVQNYVKRRLGGDRGVKIYAIGIGVALIYYVCHLERVPETGRLRFMDCSVDQETEIGLATYQETMQQFGGQILSPNHPISKRVRHIATRIVEGNNLGKMKQGHSLGAVEGPGWGQDLEYIFGEGVRKNRNPNLPADLNEWEVYVVDDPKTQNAFVIPGGKIFVFTGILPVSGNDDGLATVMGHEIAHVVARHGAERMSQMKVLFGVSLPNSRTNETEADNIGLKLMARACYNPAEGPHVWERMTEVEGMRGGNNLDFMSTHPASKKRIKALRKEQPEAMAEREKHCGAAEAAMDGGFRDQLGGWTKNNNTPVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4I0</accession>
    <name>K1W4I0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4I0"/>
    <dbReference type="STRING" id="1220162.K1W4I0"/>
    <dbReference type="HOGENOM" id="CLU_967056_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4I0"/>
    <dbReference type="OrthoDB" id="10688251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="306" mass="33675" checksum="CC4E7E3B0DBF0C8B" modified="2012-11-28" version="1">MPAPFPDDGSIVDQDRVGQSLIIEYRKIDQTRRAAASTLLGDGDMQEFVNRIRHHRGERPVGDGHLLPLEWKDAAAFEADMLTFRALHPAPRIAVLIDAARRAPEAPVFLRYAGVTAATTPSARNQADLLRTGTCWSNLTAVLERTPKVFSLKGAHSNKTMTYTAEIRLPCSPAEHRARIDLQDIERALVAAVFPLCGNSAPGGLHHQPDLSPYEAVPLPRFDVEDDKTAERLRALNLQINQHHDDARKIWSSVSRKGISDAAAEDARCNAQVTELYQGGVGIDSYGSVLHYKGMEQFASSLIRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8A5</accession>
    <name>K1W8A5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8A5"/>
    <dbReference type="STRING" id="1220162.K1W8A5"/>
    <dbReference type="eggNOG" id="ENOG502QQB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280925_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8A5"/>
    <dbReference type="OMA" id="CTHQFRT"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="359"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1117" mass="124485" checksum="07A58433FD2DAA77" modified="2012-11-28" version="1">MSVRSFSPRQRTPCLSYAEVAHPDFSNSDGDNDSNGDPLEAPHSLPDTPDTSSTNENGSPTTSPLNSTSAPSPPTVQASPGVTPSSPSVVETDTEPIRRSDFAQTVEEVLEDLPELSHPPMPRFNAPSKAELETEMSNWALREGFALKVRSNNKPRRRAGRPQRHYITYQCIRGGEYRDSVGEEARQRAASTFLTSCPFAVKVHLVPHDGRPRYLVVGHPEKVDSDGNRVRTDLHNHPPIHPGQDHRMRQLRSEILEQIRSLAKTTLSPVQIYAHICDLYPLETANLLSSDISRYCKQARASQLCGAGPAEYLRRYLAENAQREGIIYRIEQRGDDDTLNTAVWLASTSRALAHRFSTVLSVDVTYNGDRHDHKILHIAGFTATNESFTIALAAMPDENEETITRCLQTVLHLLGGNLVPEVVVTDRGMSIRNAVAAVWPSPATQNLFCSWHIEENLRTWLAQALSMYVSVQQKAQETRRAAEAAARRSRRSRPSNGPGGGFSGGATQTTTQPVATISDAPPESAYGLFDDEGRVLDSAGLLNLKKRVVRSYRQKVIQAKTEEELRNGLAAWAAEWRGESYHGALERVVVAGLRYAEDDGDGFIHCRTNRYLHFNQRTTSRLEAMHASLRSYIGDRSRRHRLPVDRLVVLSLDKFRAQWSQLRHHMDYEISHRPSSNSLLLFHQVKARVSEHALNLLKNQLGIAKNIIKRRRGVRYHRDGRLVPETPPCTHQFRTSVGLPCAHEIARVQDTVNNGSGALTMAHFHRQWWLTDSSTLLNLKDTLDARIQPGSPVVTLEIDVLQPCGPRRLLDPLTASARRSLAVGGSATSRRAPPRRGPRTHTGRLLTQAEVRNGDEPHVSDHPRCPACLRHHDPFSNPCRESTEAATATATAAERRESQRDGEETQFDSDDDDFRSINPVYLSLRAADCDSCPFCRKNHSRRWCNLMYEWRRWYAAQNAAGDRQEPASPNESFVSALEVASEPSESLEDAERVAEAVIACGESVPATPERLPFDPYYDPTPSPPTVSAADLELDDIVGWSNAVRTQRLGSIHHEWMAEQPYPSSNDSMVPETQLETSSPVPAPEPVTTPSDSEMVSPPPLRLVPEGVERSKRRRCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8W8</accession>
    <name>K1W8W8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8W8"/>
    <dbReference type="HOGENOM" id="CLU_1918546_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8W8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="132" mass="15221" checksum="A8F7656042844E53" modified="2012-11-28" version="1">MGVIQLEKRYTDVEPYYYEPWWERTSEATRIGIYVAIVILIAIAAGCIAWWIMLNRRRSSAPYTPQPAYTGTRPNVHVSPWNEQGYTTLNGSKESLDGYNVPKPPPRAYSYAEPDGIQKDEIRAVLYKYDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9F8</accession>
    <name>K1W9F8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9F8"/>
    <dbReference type="STRING" id="1220162.K1W9F8"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1016317_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9F8"/>
    <dbReference type="OMA" id="WVINIAR"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="39"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="274" mass="29687" checksum="0FFCDFE2A1D3D8C8" modified="2012-11-28" version="1">MTYVEVKVSCTLASVADKQESFKTLPAFSPLISVEALPTIALVALLAAFALTFFLTTDIVKLSKSSSFALISMGVIVFSVVFRSVGVDRSLRGDPTHAFSVVRPGVFEAIGVISFAFVCHHNTMFIYQSIDVPTLDRFNQVTHASTSMSLICCLLLSITGYLVFTDKTEGNILNNFAADDWVINIARFCFGANMSTTIPLENYVCREVIEDAFYKGRPFSQTRHVAVTSGIVFGAMLISLMTCDLGVVLEIAGGLSATALAFIVSAENRAEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA21</accession>
    <name>K1WA21_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA21"/>
    <dbReference type="HOGENOM" id="CLU_073667_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA21"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="36057" checksum="7AB414B595DC9FBB" modified="2012-11-28" version="1">MITIDAACFPHILDSVLHQLHLSGHDATLASCRLTCSAVKRTIDSRLPRHRILSPIDPVAPPRKTSLCVNHETLLWNSDTEGWRPTAISEVADLHVTGDLYWPALSAPVPVLRVFDYRALPPPSGAETLILFPDPAYVAEQGKLNRVVELCYEASRIVINMHYDHAPPDFAFRYAPEAELRNSMYRRIGVLENPQELVLMFTPTGKAQDNVRMETFLEDWTYSVALAVRHNLGLNVVLITDGWKWSWFVREEDECLREIEDEYERFVAALKRLMLVYLEQAPETDPESCLTRISFTTMEAYQSEVGPRMLKLMCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA72</accession>
    <name>K1WA72_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000043">
        <property type="protein sequence ID" value="EKD05653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA72"/>
    <dbReference type="STRING" id="1220162.K1WA72"/>
    <dbReference type="HOGENOM" id="CLU_2172835_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA72"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="110" mass="11599" checksum="BA9347380EDB15E4" modified="2012-11-28" version="1">MRLLHCQHLQPVSLYTGLMFGLSLTANLWCFFRISGGLFHPAVTFAFVLIGGITPVGGALLFITQLAGPLYAATILLGRPGLLDRGVHDPPRGPGVRPSARAAPARPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAU9</accession>
    <name>K1WAU9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maleylacetoacetate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAU9"/>
    <dbReference type="STRING" id="1220162.K1WAU9"/>
    <dbReference type="eggNOG" id="KOG0868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_20_0_1"/>
    <dbReference type="InParanoid" id="K1WAU9"/>
    <dbReference type="OMA" id="VYNAHRF"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26255" checksum="3FF31A6E946787A9" modified="2012-11-28" version="1">MSKPDETYTLYSYFRSSASARVRTLMALHHIPYDVKFIHLLKQEQSSDEYTKLNGSQTVPTLVVQPGQGDKWNLGQCIAIMEYLDEKWGPQSKYGRLLPENAKDRALVRSIVDQVVGDLFPMLNSATLGAVTDFGGDKIKWAEKWSDKFLMALERLVSKTSTNGKYCYGDSLTLADVSLAPQMYTVLRFYPQALEKVPTVKSIFENISKLPEFVQADYKHQPDTPDELREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB99</accession>
    <name>K1WB99_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB99"/>
    <dbReference type="HOGENOM" id="CLU_769844_0_0_1"/>
    <dbReference type="InParanoid" id="K1WB99"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="360" mass="40536" checksum="85CBA2350BA2FDB5" modified="2012-11-28" version="1">MSAPRAMKFAAVPDELGLLEQAVLINVLPITLLNAGRILRIVWQAQGIQWAVSLYSYNDYFPMTFEAPANKLLFSQNGVVHHALVEKEIPVAPFMTRNTPSSYRRPPFIDPARCMAAIQYSIAFDQALQLAPKAQPPVANLDWTFGGHNWGCSWVPVTFPAVIEAATEKLRVASPKLHEREGNPTHVQAVRILNSLDVTVPLGHGENGPTVRIHWTSPTVGNRQVFLRWFQKSAKGEDVSCVIHELLRADSRCREYMDSLHQDPVAPELEFNAKIGDPSCRIQYGRQYEKKGKSLKRHAEPPKRKAKKDQNGADWLVEDDVWQDADFAMYVERDVAFDLSTGEESDEVMDEDVDYDALDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WK80</accession>
    <name>K1WK80_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein ypt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WK80"/>
    <dbReference type="FunCoup" id="K1WK80">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WK80"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_7_1"/>
    <dbReference type="InParanoid" id="K1WK80"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="18154" checksum="3093C913579D83E7" modified="2012-11-28" version="1">MFILPSRQSPCLLSQYYYTPKQWDTAGQERFRTITSSYYRGAHGIIVVYDVTDSDTFANVKQWLQEIDRYAVEGVNKLLVGNKSDLATKKVVDYAAAKAFADELDIPFLETSAKNATNVEQAFLTMSKQIKDRMGSNSMASGPGGKSTIKGLGQNVEQKTGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WL09</accession>
    <name>K1WL09_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic recombination-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WL09"/>
    <dbReference type="STRING" id="1220162.K1WL09"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022672_2_0_1"/>
    <dbReference type="InParanoid" id="K1WL09"/>
    <dbReference type="OMA" id="NSAMHEW"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052130">
        <property type="entry name" value="AEBP2/jing_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854826" evidence="2">
        <location>
            <begin position="17"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="704" mass="76627" checksum="0B6FF8796F95A1B4" modified="2012-11-28" version="1">MRTTLFIALLAATANAGLFERDSASAASSHGAAATHHIKAGIEDLKDEALEKWSESDLRFWLVEQGILSPQSTREELLALAKNKASRLSSAMFGGPTDTLKADVRHAASEAEASASSFEKWAKPSAESLASEASKSASSFEKWAKPTAESLAREAKKEAKTLAAEAEASAKSFEKWAKPSAESLASEASASLSSFDKWARPSAESVASNVAASVHSAGSQAAYWAQRKYDDAKDYVFSSWDDDDLKSWLSAHKINPNPPPKDRHGLLAAVKEAYTKAVGPIYNAWSDSNLHDWLVSHGIIPPPETKRDQLLKSMKTYYYDAKDKVYSDWTDSDLRKWLINEGVLSPESPELKRDKYLKLMDEHYNDAKSTIWGAWSDNSMRQWLVDNGFIQDNWKPKNRQELQTKMQDHYHYKKHEYLSWPDARLRATLRSHGVDDSKLLGRPELLQEMRTRHIEHKNAFQKLWGNIEAALHHAYSIADTATGGMLSVLFSSKLSPEQKFEHGMSSVSSVLNKAVQSGSSAAYSMSRSADSAWSQASVSASRSAESVAAHAEASAHSVSKSLEHEWHKASARAEAHKDEASLTSAASAASKSWSSHWSSASHAASVSSLSAKQAAHSVASEASYKAHSAYTIASRSASSAASVASHTASLHRKSLSSIYSVASKSASSLASAASKSASSLSRSHEHAKVTDKVKNAAEKLKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WL81</accession>
    <name>K1WL81_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WL81"/>
    <dbReference type="STRING" id="1220162.K1WL81"/>
    <dbReference type="eggNOG" id="ENOG502S9D9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282875_0_0_1"/>
    <dbReference type="InParanoid" id="K1WL81"/>
    <dbReference type="OMA" id="SHVERIP"/>
    <dbReference type="OrthoDB" id="3366083at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="453"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120810" checksum="AB6598E9724BBE5B" modified="2012-11-28" version="1">MSDDDTRGMTVPDQVEVFRCPLCPSPRAVSTRHKLMTHINRHHSHHVFSADQLLLWGLDDCPKCHWLLASREKGLARHRCADSYELKEYDGDLVMPDGSLVPSWDTLDDDDSPGDVSDAEDDDPPAPTTSQQADNILSSIFHNSINISPSGPAPTVAAVGMRPPPLTPQRTPATTAPGPAPNCPPQSTTPRSPPNDTPTTPTPAPPRRRAPLPGPSARGSKRTAPNSAPRPRQQRPEKRQPPPGGCGADIKDLSVLLRYPAPRRVNKKETRAGVRECVGRLCRAFIQAPSAETLRPLILFPKLGYQAHCHLGRRALLRALSSYPDIPTPTPPPSGIPSHNRFTRASRMIGQGRLGAAARALEAAAPIAEATAETEAYLDKLHPKGHPLPFSHLKHPPNRPNALPFSEDDLMDAIRSFDRGTAAGPDGWCPPLVEVVSDLPDFRLAMLRLFQLVTEGKAPCRDLLCASSLTPLAKPGGGVRPIAVGSYFYRLIVKAALKAKDSTPALLETQFGVGTPGGVEPILHWIEDLVSKTADDDDPTYITFLDFENAFNSVSRVDMADAIKKHVPHLLALAEWSYGARTPLLSHPDRSLKPLRYSEEGIRQGDVAGPLFYSVTVRDPLEELARYIEQIIVAYLDDTATAGRDPDILDKIEEFLIRTKSSLRLNRRKSFTISTADIRANGVEILGSCVGPVERRRDFLSKRIDAEESKLQLLHTLSRQEALLLLRASLQLNLAHLLRSLDPTGLEDLWQRYDELLYDTVRTIRGPPAHPLLYEVDESLERELVTLPPRLGGLGVLSHVERIPAARSASRDSAHHLISSFAGVEEPDDRSPQYLRHQALVDRRFRLLLGKLNPYQTARIAENASRFGKAWIASYPTMPSLRLRDSLVSAGLCYRALGVPSAPVCTLCRGSTGWGHEDTCSNLQPSRTIKHEAIKNSLIAAFRSIRGVYAGEEPSIANRPGTFNDIRAAGPPGSEFVPVDIDVNSTSLARGDLLKILDEAASSDIALLPDPLLPYKQAINRALERAAREKYKKQPPATLDSFAFVPFIVSAGGTLADTGESALRSWQGTMTEPAFGALTRAISVALLQAREPRFGTAEGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WLP8</accession>
    <name>K1WLP8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WLP8"/>
    <dbReference type="STRING" id="1220162.K1WLP8"/>
    <dbReference type="eggNOG" id="KOG0760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_15_0_1"/>
    <dbReference type="InParanoid" id="K1WLP8"/>
    <dbReference type="OMA" id="WEANYER"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="135" mass="14334" checksum="C144ED45A1AE714A" modified="2012-11-28" version="1">MSVPFTAVQFSAYESLKSFMNPSGAYSPVTHVVAGGIAGGLAAAVTTPLDVAKTLLQTRGSSTDERIRNARGMGEALKIIVERDGWRGLKRGMLPRVLTVAPSTAISWLSYEFFKVLIRQGGVMPEAGQPTPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPF1</accession>
    <name>K1WPF1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPF1"/>
    <dbReference type="FunCoup" id="K1WPF1">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WPF1"/>
    <dbReference type="eggNOG" id="KOG4593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021480_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPF1"/>
    <dbReference type="OMA" id="YKLDFMP"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="371"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="642" mass="73322" checksum="8503056878462F74" modified="2012-11-28" version="1">MSRTPPVGSRIPSVRSSFRPTSTLGKRPAGEASLSEDPVATRRALTQSVSKQNNLERKVLELEKRIRQRDQEVEDQRIRIETLTNERRILLEGETHEKQIGEERERAWAQEKLNKERRKATESTAELSEVHGKYTMLSAQHTSLKQEYQGLDEVLNGRIEELEGDVNKLRSYKKKAEELSIQLKEEKRRSEERERAHRDAENDRKGEEVVRRELKTQNVVALQKSNDELQSEVSELRQYKKDSQSADRSSKELERSLRAEIRSLNEQLERARREVDRLEALSQLHRETESQLAAEKAQNESLHDRLSRLASDSQQASFTLSKRAEEAERELRWAQERCKSAELREELVRKELEAVRHGLGASSGGADPQRVKDLERLLEEYKQQLEEMSRDSRDLETRLAGGKGLVKRSELEDEQERCKALQSEIETLNSTIEELNAANSTLDGEVTELMKRVASGEFNPARERCLELAANPAAKVKAVRAQQLEELKAENAALLERLAGAGEAVPLMVYEKLVQERDDMKVNHEKRLQRLKEIFGIKSREILDAVHSLLGWRIKFDDNGHDIRLASMYAPKGRMGLTLKFTSQEGHFGTMQMSGGLARGLEEARDFWVAERQSIPGFLAQVTSELFEKTTMGRAAGYVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQC2</accession>
    <name>K1WQC2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQC2"/>
    <dbReference type="HOGENOM" id="CLU_415725_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQC2"/>
    <dbReference type="OMA" id="RTWRRTN"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="660" mass="68165" checksum="4ADF8EA546CE519F" modified="2012-11-28" version="1">MGRRKNKGSSQNGALRAADGSSAASMPQPIVPSSTPKVRRSSRVNKNRALNSDAQAQQSGGTGKLGSPSGRKRLGTQADGVSAQATNLVSQQPQQAPKKRKRVASTSKGTSTSVPDVRRPPPPTSSTSNKGLSTGKDKAATLRLTGDPARMSDLDARIQAKINARAQVALSLAQMPPAPVTPKDTGLEAIIRAKIRARADSLGSSSVYSPAAPTATSPSVPSSHHRPLRLLGSPGSGGISGASPGNSDHPPAGTPRTSDQARSAKRSKRQQETQTTPRRTVYVEIPRRARISRVSTQPSARSPDKADVPLPQVPSSLPADTGGGSGSSPTDTLSSRIAAKIRDRAEKAEARRLSLGTGSQVTTPPAPAMDTLTAKIHAKIQARAKEQAERRMSQDFQTAQTLITESGSPVARLSESGTRSTHGASPASGPAHVGARRAKADNAKTSNPKKRKSQNANDINTQQGSAWAPPPGPLGSKGLAPGPRGSRDASLVSPHMASPVSPGSRSGPDAFRRSLPLSDSESSESSPFSPQPQRTQSSLSKQASRTSSASVSDILASSPGPFGGLSSPQSEMTFLIPSSPPSPPPIATASAAETSTSTAETAAAAATSAAHANVRSRWRHRSPERPGSAEHAAKDTGKGAVSTPQLVRAGPRWTVTTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQL8</accession>
    <name>K1WQL8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQL8"/>
    <dbReference type="HOGENOM" id="CLU_2723999_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQL8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="72" mass="8126" checksum="392EFCA42EDE0C0A" modified="2012-11-28" version="1">MGTWRLIRRFYAQAFSGEWTIAEPSNIELGPYDIYIEPNSNTTVTIDYISIEIPLATNATTGVDEVAELWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQW4</accession>
    <name>K1WQW4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQW4"/>
    <dbReference type="FunCoup" id="K1WQW4">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQW4"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017554_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQW4"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="376" mass="42602" checksum="7ACFDF80DA4A73C1" modified="2012-11-28" version="1">MPSDLSYWLISVPLHDGDPSSVLQDVRHATGGQVTCGGWEIPDLKAGTLSSLISLSDALPKTDAAFTQTVSKLLDTLRSLVNDDKDRMQQHVRVNDRPVEEYLIPDPQGSGSWRWDKGRWGEGGKVVDVIAALQSEMNTIESSQKQKTQQYQLAKGALNTLQRKQQGNLAQKSLIDVVKKGDLVEGSEYLETLLVAVPKNNIKQWYDNYERLSSMVVPRSSKEVAEDGEYKLVTVTLFKKFHDEFVHKARENKYQVREFKWDDDASANQKEELERLEKEEKELWTVRMFVESVLRYGLPADYAGVIVKPEPKTAVKTLKQLSAQYNDLASGKSKEKAAAKRKQAPGAEDLIGEWANVMEQEYYDFVLFELPKVQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTT0</accession>
    <name>K1WTT0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTT0"/>
    <dbReference type="STRING" id="1220162.K1WTT0"/>
    <dbReference type="eggNOG" id="ENOG502QWBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_1_2_1"/>
    <dbReference type="InParanoid" id="K1WTT0"/>
    <dbReference type="OMA" id="NEYTHAE"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="456" mass="49905" checksum="FED8C8CEAFA5BC81" modified="2012-11-28" version="1">MPVEPLTFRFLGTGTSAALPVGPCLAGVSKPSRDVGEFLKFYEQHSSSDASPSRWLGYDPKGEWPANVPCASCRAAVDRSVPDGWKNRRGNPSLVISRGGKNLLVDVGKTFREQSVRYFPRWGIKSIDAVLITHGHADAYNGLDDLREWCNRQGAAIPIFLTQTTFETVSASFPYLVDKTKASGGGDLPSLDFRIIKDDEELDVLGIHVQALPVEHGKYFTPTPAAEVGPSKPATPAPGKCCGDDGKATEEHKASGEQKDGAVANGGANGGKKEEVTYVPHPEQRVTTGYTPFLCLGFVFDRSLVYLSDFSLITDSQWALLDRATAHHQLPLTLIVDALWPVRPHTSHVSFPEAMSVAERIKPVHTWVLGMTHPTTHEQWARMGRSVKGVEEEDDITTKELLRKVWDSYEMRTNGDKIRHWGGDVEPAWDGLGVTVDQEGVHEMPLGQGSAGGWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVC3</accession>
    <name>K1WVC3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_00895</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Chromosome</location>
            <location evidence="16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1WVC3">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WVC3"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_11_0_1"/>
    <dbReference type="InParanoid" id="K1WVC3"/>
    <dbReference type="OMA" id="DVRLYRM"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="19">
        <location>
            <begin position="1956"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="2639"/>
            <end position="2949"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="20">
        <location>
            <begin position="2947"/>
            <end position="2975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2389"/>
            <end position="2411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKD04784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2975" mass="330928" checksum="86DF1AA2A395515B" modified="2012-11-28" version="1">MNTVAGLQTALSNIESEKITERKAGQDALREIFANRENLLVFQETATLEGGAGWVALFQSLFQGVVLEKKVVLRKPAAVGTYPPHSTSTESPSLKGIELTTTAERRLIQAANLVRTTAERAVNLLSRRPFLALFTHMTTLLVHDGRIFELIATDYIKALRTLLSYPPHLQHLDAGSWRTLMRICWAALLGEYVSLEEDDEGSASDSSLAPTRQKVALSASVANELMTLIPILVASPAAPLLPPSHEHSEPSDAGSGSGILQKISRYIRKQSGAPLPLEILRTLNTVLGEMELNSREDFQAASLKLFPQLVDQWIATSRTNLGLREHIVIAMRMMLPFITHITVKDFDQQTAVRSAMDKFIDSITKESRSRAGIRPLDLDSLQLVSVSTQAPSARRGPFELTGLTAGFEFDASQAVSWAAIELYADCCFQTYKQNAVPSTPSASARKRQRMESSLDKIMHLTLGNDESERRIALQVLVFFFNKHWKNLAPDARDSIRLKMLELLDDEDAVLQSWAYVGLSSLAHAENAMEAEEIANRSLPMTPAAVAARRRQEQTAWERVWTHAVRKTSFIATSRAACHAVDTIIQTGKVDSARCVKDVGNLLRNVDIQGPPTVTDAACAFLTTAVESVRADAGLYAANLEEKVIDWFAKTYEVDGGSRLRNRMGSATTAGILRLLGAICGFSKAAIADTTVAEHLVDSPVVNRLIHEYQTNGLRQLILYGTMPSVPGDEMEAAVSVGISAKEDSESLGFLEGRPRKLSDFLQATAQITVNEWSPKDQRSSPLTVIRLRKSLDAVALLLTFQAAVQLNGFRPDTTGCIMTAVRLLDTVLPHLGSLSENVAAQHLVWRGVAPLYSRLSSNIDAWPILLKPDRPSGIRKDKLPPRRYASHIPEDGEHKPGPYDDLLSIVWRKGEVSQQVFPHHANLQTADALLRLIEVSKTTLEQVRPSTVATSSTVVGYNDDDDFGPIINAEVDAMPQSFEAKEAQRTIASLTKTLVELRLRGPLLAHPDRIPTKDNDLFNSLATADGTRFPQLGFVICDAILEGSLRLSGAAVSLILDELHDRLTTYAFNRDGDTIKLAILFLARSASIWLAPKFGLTDLAVEQAKEIVRLASTGRLHSWQARLHLLLFIDEYLDYDPSYGAWLQLGDTDEADIEMGGHHESDWGPLSYVLKATLDVDARVRFRAASSAAAIHYLPDLSSERKAQAYLDLLPKQVMTVFNWDVFLTNLVWKLNTCIASALLRSATIFHLYEVADYNPDFLSHLQPGLEAVAQRLGLSSLQPLYMSHANTIVTQQLQNQQLPLRLGPTLYGCSSRREFAQLCLNLVGSTILATRQNTAFFDALCEAADVPKQRALGRCVPAAAAMAVTYSFSQGETGRVTAQQTANAEDVLKQLPSPDSRSCAEYLAAHSEIVMASLFPLIDLALCNSDIASMLAGFNDDGRASQCYVTLTAHDVDPRHAPTVLEPQYSFWAVLQALLFLRTRFQETLSRRRMVFSALIKLFHSINSSYLVIEQRRYLRSLALLASLYPKEFQQPMVLQQFLHNIINLLSSEDNGPMLLDLIRWGFDQLAATKSVPDGLVDLLVMLSTTYTKLKGDSNLRETADGLTALIRDRAKLWQQNKEIAPALEYAIVFWPPEWAKYFEETFELGFVDVANIAGRPATMNPMALCKRLSASAIIGNRAQNRDTFMSSTFWHLKKALTASEWDRNGIMAFLDLIYMSNGQVKAPDMQAIKSLAGRSQLSDLAKDYKDPKVVLRITVIDKIVEQTSADDYQLRTTAIEVLQTVLPVISQMSERQKMPTRLNELAGLLVPSTPTSSSQEQAIDTILEETKAWVVKSRVCDTWARDMALLLSTLAARDDPFYLSLQPLLSTPGSTTTGFLPYLVQAVLSCGFEEHSDQSLHRAAVLSDHFSQVLQYPMAAAETLEAIINVVLHLRNFQPPHLSNDLAYNHWLSINPLILSEAAGRCGAFASSLLFLELSNDWNDGAGCDLSSPRVQNDPDGFYGIQNNDVMDSLLRRLDHEGQPLNSLGYNLANVEAAPGLKSGPSLMSSMRNLHDLGFNRLAGSVLQSSRQALGDSEADPFFLDLAWRMSDWDVPLTPDMTATPAGQFYSALRAVHRERDRSVAQQIVDGAIRSEMARLEKIGVERMTEVKNATLNLLCLRDIAKWLSEPIQQAVNEGDFASGRLADFKQAERLSATRLSLIRSSRARESQTMFGDLMTAQGEGLVDLEISCQLRLSHLARKELDLQAAVNAVMAVRQLEGATPSEHAADEFGQVLWAKGEHGLAIQHTQTLYDAIQASSKSVNQARSAILLGRIANWTSLAKLKAAEDIRASFREAMKLAQKHRSDTTEQAQLAYDFAVFADQHYVALSKSPELERLTVVMDRKRGELEKLDSMRSTPSSSRRKADKEDLELEEERAAKEKMDRELLRYLCFTLESYASAIALSDKHDDSITRMVSVWLEHDSTEHAQRSFSSHLGMIPTHKFIFLSPQLAARLDRPKQLTTFNANLNDLMLRMAQDHPFHVLYQVITLAQGSDYKKGDGAGRTAAASEILARITTDSERPIAQRAGKEMDAFSSAAVQWCNFDYEKRRIPKPKTMAPAPVPSQCPLMPFKRLSIPVATFIPPIDLTLQYMNVPTLERYRSNYRLAGGLHRPAVMSCYDSLGKEHVQLGDDEVRQDAVMEQVFEMTNRLLARDRRASARNLKFRTYTVVCLANRSGIIEFVGNTQAIGDWLKDAHIRYGKSTDLAPDAVRDSLRRIQVKDPDSPKLVDTWKANMKRFHPVMRHFFTEKRREPLAWFQMRLNYSRSVAVTSMVGWMVGLGDRHCSNILIDKSSGELVQIDFGIAFEHGMKLRIPERVPFRLTNDIVDGLGITGVDGTFRQCAEHTLRVLRESKELILTVLEVFKHDPLYTWTSDATKMRRAGGGRSDTERGQDQADRVLSRIRGKLGTELSTEYRVNQLIQEARDPEHLAKIFVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVH5</accession>
    <name>K1WVH5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase RpdA/Rpd3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVH5"/>
    <dbReference type="STRING" id="1220162.K1WVH5"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1611965_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVH5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252">
        <property type="entry name" value="HISTONE DEACETYLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252:SF77">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854988" evidence="2">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="17889" checksum="F76EF5753FD53231" modified="2012-11-28" version="1">MRGHAACVQFIKGFGLPLLMLGGGGYTVKSVSRTWAYETGLAAGVELGSSIPNNEYYEYYGPDYELDVKPNNMADHNTREYLDKVMSGSGVGVLGSQVFRCSGDQELAKDGRNHGHGWSKVNQSKADRGKPRSLRSVFVSGARSARSSKVRIEDRGFCVGADSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V006</accession>
    <name>K1V006_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V006"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="InParanoid" id="K1V006"/>
    <dbReference type="OMA" id="DACIGQW"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006526912" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="718" mass="74810" checksum="46CAAD1A00C0D624" modified="2012-11-28" version="1">MQISVVAALTAAALGSSALARLNPIDHPVLQARYDPLSTAGTNVTQTPPPTASNSSTRFRTANTESFYVPSMPDVNFQFGEMYAGTIQLDSTTVNANASGTGSNATAQADEMFFIFMPKEGGEPVDELTIWLNGGPGCSSMEGFLQEVGPISWLAGTHSPERNKYAWTNITNMLFVDQPIGTGYSRGTPSATSQPESAAQFLAFLKKFQALFGISNFRIYMTGESYAGRYIPYIADAMLNANDTQHFNISGAIIYDGVIGNHLFTQQQLVAYPYAEENWSHFGFNSSDMATFKELHQQCGYEEYINKYMTFPASGVQPPRFWNRTDPETSKCDLWNSALIGVLNINPCFDPYESNKPCPILWDVLGMSGITNLVPPGTTVYFDRPDVKKALHVPADLTWQQCTKKPVFMAGNGKAGPGQNGDLSEDPIQGALPRVIEATQRVLVANGDFDFVIMTNGTLLSIQNMTWGGALGFQSQPSEPLFIPLRDIQHREAFAASGLGIDQFIMAQGQMGIQHYERGLMWNRVWGAGHMLPAFQPRVAFMQLLWMLGHIDSLGPISAPAGGAGGAAAAGNGTADSNVMSSGNNNGAMSGATAGNSTSSAGSMTGGNAAVGIDSAAGNTTASGNGTVGSGGADGSNAVGGNGDGGSAGSGDLAASGVAGAMVSQAGSSPTASGAGTSGPATVGDAAGGGHAAGGEQGAGGEFVAWASSEFTFGSDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0U4</accession>
    <name>K1V0U4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0U4"/>
    <dbReference type="STRING" id="1220162.K1V0U4"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083411_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0U4"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="31978" checksum="D2C106BC32087585" modified="2012-11-28" version="1">MFKPLPQVLQVQRLATRLGRTRRPLRPTLESRISTTSPLSNALISAPLHARRQMPIKTDMASQETPNGVVKDAVKDVQIKGAGGKVLPEPYNVPAHAGAAEARETLRLDPGGREAGRVTSCAESMCLVHDLAEAYVGDITPVEGVPASVKHELEEKAMSAFLDEMLGGPSNAQARERFRSLWEEYEARETPESKLVKDLDRLELVLQGVEYERADPSIRSLGTFYTGSIPDSPAHLEHPSVRGWAESVMAERKQLWEERGRGEEEQAQLNGVKVGEIADAKARAKAESESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V144</accession>
    <name>K1V144_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V144"/>
    <dbReference type="eggNOG" id="ENOG502SRRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115517_0_0_1"/>
    <dbReference type="InParanoid" id="K1V144"/>
    <dbReference type="OMA" id="SCITHSY"/>
    <dbReference type="OrthoDB" id="2581067at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851544" evidence="2">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="193" mass="20855" checksum="03811F1B111B66C9" modified="2012-11-28" version="1">MLWLFGFLSALLCVTANVGGFAYWPVLSPSPSIPWVVGEKNILAWKTAAGLGIETFDVQLHNVDKKVMDGFIKLALRVPHAAAGKYGTYGGELEVDLTEDVPTGDKFVVIFTESMHGQVYAKSEPFSIFKAGEQPGNYSSNPDKVPEPKTTATLTEGPVPTQEWAITLSGKPKVYSTEMDAAEKAKETATSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4R6</accession>
    <name>K1V4R6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4R6"/>
    <dbReference type="FunCoup" id="K1V4R6">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V4R6"/>
    <dbReference type="eggNOG" id="KOG1763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042870_1_0_1"/>
    <dbReference type="InParanoid" id="K1V4R6"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="35901" checksum="FC7B2E9733A1F54D" modified="2012-11-28" version="1">MPPKKKVADDKTFGMKNKNKSSKVQKYVQQVQQQQAQAGKNKQEIAKQKEAEARKKQKEAEAAKKKMDAQLFATAQVQKVPFGTGNKCKFSHDPNVGRKAEKVNIYEDAREDKNTDTMDKWDDEKLREVITQNGRKQKTTTDIVCKYFIQAIEDSKYGWFWICPNGGDTCMYRHALPPGFVLKKDRKKEEKETISLEEFVEVERHKLKPPLTPVTPETFAAWKKSRIEKKEAESQAMEKAKATARAAGKLTGMTGKDMFEFGGELYAEAEEDAAEEEWDISRMLARYAEEEAEREKEAEDKAKADALAAGMEGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5F5</accession>
    <name>K1V5F5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5F5"/>
    <dbReference type="HOGENOM" id="CLU_523974_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5F5"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="539" mass="60486" checksum="9B88A52F041EB4C4" modified="2012-11-28" version="1">MTVTAPFQPASKLTASALLKEEIAVRAEIGVLGQRLRDIEQKKAAMTPLPEDKKEWVKEADSWTTVSTTPPGASSLQADVLIASTFGGLRPNRRRLTGSLRFDGMVLKDDQTPADVDMEDGDIIDCDLDPKWARPPPRVSKTMLRNPRDRTSQQARSSTLVLISTNSTELTPAMTVIDHNVFPHIMEAIYSYADFDTLLAMRPTSKTYRDWSDARLSEHVVVHVRRPKNEQGKPIWAAGSRSVEIHAPGGRRLPFFRSWKRANGDDLSQWRAFGKYFGRTTTLDLADEGLMRGRTECIKAVCPKLHTLRMLNNYESEREVANMSSSAVSFPSDAKDGTFVQFCYAAKPADPMAEGRVSRALFVNPIPRGVRRCVVNLIGDMRDPKLIFIANTTLPPELRELVLVFHQIAGPTPEVKDDYQIPSATLHCFHSFAQLIAQNAHKCKITMAGALGVSERVYGFEYMEDQDELRDTLVEFLGHIADEQTPMGPDEIKKANAAFHDIPWPSVAQYRKTLAPGQWENESVPRPWYSSPELSWYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V742</accession>
    <name>K1V742_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V742"/>
    <dbReference type="FunCoup" id="K1V742">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V742"/>
    <dbReference type="eggNOG" id="KOG3265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060354_1_2_1"/>
    <dbReference type="InParanoid" id="K1V742"/>
    <dbReference type="OMA" id="DYADQEM"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="211" mass="23332" checksum="3737B0EEF0306391" modified="2012-11-28" version="1">MSIVNIRNIELVNNPAKFDDDYHFRIKFEAIAPLAEDLEWRLIYVGSAKSEEYDQELDSCMVGPIPAGVNAFDFVAPAPKHDLLPSVDPEEILGVTVIIITASYRDKEFVRVGYYVNTDYEDEQLRLEPPPQVVWDKLYRNVLIEKPKVTRFQNPWDSGSADPYGAPNGDGQAELDQPLSADAVFNSPLPPPVQKAPAPSSGMDVDGGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7G4</accession>
    <name>K1V7G4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylic acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7G4"/>
    <dbReference type="STRING" id="1220162.K1V7G4"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="InParanoid" id="K1V7G4"/>
    <dbReference type="OMA" id="SWVGGYV"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="84"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="537" mass="59329" checksum="2F08F1358DA80E2D" modified="2012-11-28" version="1">MVSPPQSFKDTPRHYEESDDGLAHTSVKSQLSHWHAIKGREHRSFVRNIVPSFRWKTQKNSPNEIVIHNPIKLLRSVPAKGWLYFLVGWFAWTCDGFDYFAVSVTMTDLAHYFGKSNHDISTAITLTLLFRSLGAFLFGIAADRFGRKWTLFVNLLMIAALELGSGFVQTYSAFLGVRSIFGIVMGGIWGTSAAIALENVPPHARGLMSGMMQQGYAVGYLLAASVNFITPHSKYGWRCVYFFGAGFSLLAALLRLVVPESKQYIEARERAKAEALPAKEATRRFGRAILDMLKTNWIRVIWAICCMTGFNFLSHGSQDLYPTYLKETKLLSPAVTNRAVIISNVGAVCGGTIAGYLSQYSGRRLTGLIFLCITAAFIPLWILPGNFSGLAAGGFWMQFGVQGAWGIVPIYLSEVSPPAFRALFAGLSYQLGNMASSGAAQIETDAGESIQIPDPKEPGKMMPDYATVQGILIGAVIAWLMIFLFLGPEADGSHFEHAKAAYEEGAGKETGTRLVHEDEYIRRESQMHREEREAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7T8</accession>
    <name>K1V7T8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000351">
        <property type="protein sequence ID" value="EKD00065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7T8"/>
    <dbReference type="STRING" id="1220162.K1V7T8"/>
    <dbReference type="eggNOG" id="ENOG502S19E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_0_1"/>
    <dbReference type="InParanoid" id="K1V7T8"/>
    <dbReference type="OMA" id="WHRLNPW"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26565" checksum="273DF78BE69D99AF" modified="2012-11-28" version="1">MSPAPIPKVLAFDVFGTVVDWHGSISRAVTALRPGVDGDAFALAWRAGYVPAMRRTMAAIADGSGSFRVLDELHLEILRSILPDFPQLADLSEAEIQDLNKAWHRLDPWADSVEGLTRLKKKFVITPLSNGGIGLLTYMAKRAGLPWDLILGAEVFQAYKPDHRTYQGVARVLDVKPEEVMMVATHHSDLDAAQDAGVQTAYIERPDEMGPRKELKDDTPKERHPLHFKDLNALADYLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V936</accession>
    <name>K1V936_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="10"/>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial DNA endonuclease involved in intron homing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the LAGLIDADG endonuclease family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V936"/>
    <dbReference type="STRING" id="1220162.K1V936"/>
    <dbReference type="eggNOG" id="KOG4769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542038_0_0_1"/>
    <dbReference type="OMA" id="EVRVINI"/>
    <dbReference type="OrthoDB" id="2443709at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006314">
        <property type="term" value="P:intron homing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0404">Intron homing</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="503" mass="57182" checksum="D3B4B1576843907D" modified="2012-11-28" version="1">MPLSGIQSHSGGSVDLAIFSLHLSGMSSMLGSINIITTILNMRAPGMTLHKMPLFVWAMLFQAIIIIMALPVLAGAITMILTDRNFNTSFFDPAGGGDPVLYEHLFWFFGHPEVYLIIIPGFGMISQVISAFSGKPVFGYLGMVYAIASIGILGFIVWSFYLNIYKVVALPYCEVRVINIAVCWNSLTLIGTFNSKNLISYTQSAGNRYTSSNRSLTRSSETKRNTSFNLIKFIDHYKNFYNLPVPDYNWLIWFIGFREGDGAILCYKNRPQFVLTQKEGRILYHIKKVLRFGIVKYYPTSSGGYYRYIVSDLRNIKTLALLFNGNLVLNHRINQLNEWFKVLGFTSKFVVTPVLPTLNDRWLSGFTDAEGCFNVNITSRLNTVTGYRVSLRFLLDQKNAQITLEYIKNLFGFGKVSLRSGTNQVYRLTIDSFKGLVNVRDYFLIHPLRTKKAISFIKWNEIYTIRLNKEHLDSKGLSKIKLISKEINLNNRETIKTGSSKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V966</accession>
    <name>K1V966_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V966"/>
    <dbReference type="HOGENOM" id="CLU_769845_0_0_1"/>
    <dbReference type="InParanoid" id="K1V966"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="360" mass="40111" checksum="E23161054A1B9CD6" modified="2012-11-28" version="1">MSAINHSTFPLMFDAVWDAMDTATVLACRNVDSRWRKRADQRLQQHMMLLPAISRADADPSNLAYTAHLPATLCSRDAPHIASLRCELPPPDAPIAVLKNTMLSIKPTFSNLRVLDVDCSGELHGAASLIGPLFVATCPHAIFRAFVPTESLGQVVGVGREQVFFMDLERPAKIITYKPNPVILNLRCDAEENSPFQFVQSMGGADLWHVLDHQLMYKRHAVCICGFLFTIANVDLSYLDSLSVWLGCSSLPTHAALTFETQITLVGFERLFTEERDYRLFKHYVKCRYSGPLGAPGALDLGGRGAGEQFMGPVDPADVRSPVLADWTVSPLRRLLVRVLTRQEYEDEVGSEKFTLYTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAD9</accession>
    <name>K1VAD9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAD9"/>
    <dbReference type="STRING" id="1220162.K1VAD9"/>
    <dbReference type="HOGENOM" id="CLU_180253_1_0_1"/>
    <dbReference type="InParanoid" id="K1VAD9"/>
    <dbReference type="OMA" id="TNIAWGR"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854024" evidence="10">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="101" mass="10989" checksum="81C650D0EFDAEF48" modified="2012-11-28" version="1">MTNIAWGRFLTTSAVLFLPSSAPGATALLEELTAVIGGGYALLVTTTPTEEELYNRLSPDLRRKVDEIRRQREGGDNAVKEQLAAAGDTDKIVWASELNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAY0</accession>
    <name>K1VAY0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol carrier protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAY0"/>
    <dbReference type="STRING" id="1220162.K1VAY0"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="InParanoid" id="K1VAY0"/>
    <dbReference type="OMA" id="PSLYAMM"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="2">
        <location>
            <begin position="271"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48603" checksum="8855815BC732FD60" modified="2012-11-28" version="1">MVYSPRKAYVVGVGSTKFDKPRGLRDYPELGLEASVKALLDAGLTYDQVETAAVGYVYGDSTCGQRVLYQLGMTSIPIVNMNNNCSTGSSAFVSAVNSVASGQVDCALALGFEKMSPGSLKSHWDDRTPPLLGTHMQLTEIEESKQYFVKQKGPGAAIIFAAAGLEHQERYGSKPEHLFKISFKNHKHSAKNPYSQFRFTPSPEEVGAARKITRELTLPMCSPTSDGAACAIVVSEDFVKKYGLEDRAVEVAGVGVATDSPKLYETRSRIELAGTDMGRKAAAQAYKQAGITANDVQVLECHDCFAPNELITYEALGLCPEGKAHELVDAGDNTYGGKYVVNPSGGLESKGHPLGATGLGMVFYMTLQARGEAGPLQVPNVRNALTHNVGLGGSCIVTVLRKADFYKKGSTSKDRLGYDFAAEVREITQKDLDKVRSKEYSNYIPPALAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBC6</accession>
    <name>K1VBC6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBC6"/>
    <dbReference type="HOGENOM" id="CLU_636450_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBC6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="431" mass="46281" checksum="9387E43941AC97AA" modified="2012-11-28" version="1">MSRRTGHGNDLDRAGPRRLSRFLHSCVLIDPAHPGLVNNGYRPATPAPTGAASAINKLSAAIDSPAATIQQEIAAPTTIPPPSPPVTILVDPRGAFVQLSHDGRVRGPAASTGATCAAAAAVWTRAAKKTECPAAIEAGGAETPAVIPDADDAVSVPAHSDEWSSAERPWHIVSAAKRLWTRGANSVDVFRQEARAAADTVKGALSDCEPGAAPPLGGDVRRGADKPGQSRAARRAAAPAPLARRCVLHRLVQDHGHGAQADTLVLAPAAQRADDPEHAERAECAQRPPLVDRTFARQRHPAEFPPPLAPARAARVALFDRQLRRRDRRRDGHEPAHECADRTSARNSARASARASARGPHLTDLKMDRMDDLPPIKKVEEKQEKPECSSVLFGRRFSMPVPRIKSMPEIVRPLRRLSFQPRGHSLDRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBE5</accession>
    <name>K1VBE5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBE5"/>
    <dbReference type="STRING" id="1220162.K1VBE5"/>
    <dbReference type="HOGENOM" id="CLU_1180932_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBE5"/>
    <dbReference type="OMA" id="ICPNDNA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852020" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="22203" checksum="72E3972A13A8B63B" modified="2012-11-28" version="1">MKLSLLVAAAAVSYVAAQDDPLANVPDCLKKCGEQAAKDLGCQGLTDAQCVCSKQNELIAKGAPCVTADTSCLQYVAQAPGMISGVCNQLQNGAASSASESAGAAENTASSADQSASSAQEQASSASEEASSADAAASQTSSAVSAESSAVSQSESASNAGASASQSASASASNAAEGIKASATSALQSATSAAGSAAGSATSKAADAAKPSGGAMPMVASAGSIVAAVLAFAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBW4</accession>
    <name>K1VBW4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBW4"/>
    <dbReference type="STRING" id="1220162.K1VBW4"/>
    <dbReference type="eggNOG" id="ENOG502QPU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337450_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBW4"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="844" mass="94018" checksum="2603330C42ACC828" modified="2012-11-28" version="1">MNVLLARRLVRPDVLRRAISTSPVFFDASAPAAKPNSDGSKSSSGPSKSNKGRLNKTRKPSFNSKAARPEKPGRGRSLSNSRKPNRKPRREDDEERLSKEVSFRDGVSQYGLKKPGSENGPRKPWKERPAAVAAGAAAAASGARASAALRSDSASEEEKERRMLDEAMAAEDGYTRNAPDVEDPLVAVEDIFEPLEKSVLAASDVKIVPVKPPRDAPVARLNNRLQRVLFSPGVHHMRDPRTGVFNFDQALERIPTPEEFAFHRLPQYITASQDPELTGMATTNNTRYTGSTSTLTQSLSQIYFTLSNARPVDTSTLSAEFQEQRPDFTAGAQLPALINIRLQENGTYAIDNDKTHSIDNNVLSDYGRILEKQLTASPEDFKRFLNSAPESAVPESERTEREAYAYSKSGKLLMRSQLDCQDSRLPGSGTFDIKTRACFPIRQDRANWEKNAAYTIYKQHGFQESFEREYYDLSRSGMLKYCFQARIGQMDGIFVAYHNTRTFFGFQYLSLAEIDRVLFGSTEMADQVFQLCVGLMEKLLDKATDLFPNESVQMSLRRQAIQRPDGTNELIAVVQPVGGADRPKRALALRVQNVLDGKPVSAEALKFSENPEVRKQQQWAVNYTIAISPEHFDGQEAVQTEWNTVVGLLTSMNHLYIPDGKTRKEMYLEDGAKLGASATPPKKSDDDDSLFGSEDIVEGPRTQWRLPSKRIAAIRAMAQQSGRQAAVREISWPQSRDGDSWSPEPKGLTEAEQAEWDAKVAKDLKELLDRHHAEKIEYFAAKRAAAQAKRAKDAPHFDARDEEADIAMEASRKTQGQKKAPSNTGKKSDAEPEVPVVSCAWPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD44</accession>
    <name>K1VD44_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000383">
        <property type="protein sequence ID" value="EKC98685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD44"/>
    <dbReference type="HOGENOM" id="CLU_2442435_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD44"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="90" mass="10270" checksum="7C2615F26D81E821" modified="2012-11-28" version="1">MADAIATAIRTARTNLENAITDARKATETEHKRITELQKEIALLQFEEQNIADAWPDIKREAEEERAQYDKEAHARLAALQQDVLRRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VED8</accession>
    <name>K1VED8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VED8"/>
    <dbReference type="STRING" id="1220162.K1VED8"/>
    <dbReference type="eggNOG" id="KOG3372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068714_2_2_1"/>
    <dbReference type="InParanoid" id="K1VED8"/>
    <dbReference type="OMA" id="RSYNTKQ"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="164" mass="18998" checksum="570551F7DE67642D" modified="2012-11-28" version="1">MYSTFQRLNQLSSLATTAVMVLLGLISLASWYHQPTPAPGKIDVKSLMITRGRNPSRWRAPEEDVLKLKFDVKADLTPVLRSYNTKQVFLYLLADYVDEVSKEAHQVVLWDRIVTRASGDFRSVDAFHDGRQKHRKTKTYKNAKIRLEGARNVYFWHQPDGKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VER5</accession>
    <name>K1VER5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein priA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VER5"/>
    <dbReference type="STRING" id="1220162.K1VER5"/>
    <dbReference type="eggNOG" id="ENOG502SWWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874888_0_0_1"/>
    <dbReference type="InParanoid" id="K1VER5"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852100" evidence="1">
        <location>
            <begin position="17"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="251"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="318" mass="34822" checksum="8119D647C90875BE" modified="2012-11-28" version="1">MLAIAAVAFMAASARAIKYTNDFSSELTQRFAEREQMNFNSSPCTNVQRAECYVNMENMDPATCQCVGLQPFQRTPNQPVADTALFPFSFSKDVSALAGCWDQGKVADSEGQCISLEEGDEEHEKRTFLWRWGRDPGTACSNASKTKRCYKLGFPCDYRCVCIDPPQVCNKCYNIFAIKKCFLQGLQVNPDCSCKPRRRCDCWDQWRCQCKGGHLDDNCNCVVPSSKPRWKRAPACPAGQKSCPVGGGKNECIDVQSNLESCGGCAQGGDGIDCTTLAGVNNVRCIKGECVASSCKPGFELFGNQICVQTAEAVEATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFF2</accession>
    <name>K1VFF2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFF2"/>
    <dbReference type="HOGENOM" id="CLU_924982_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFF2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="301" mass="33286" checksum="796E5D734666A2F2" modified="2012-11-28" version="1">MAGGYFAFLSNPHGFFQQGFNLEDSSTWSFSSSTVALSSHHSSPEPSSTTSSVTSPASSLEFTKRRNYHSLLLLLRMTDNNNPGTPIYDHYKRRGAISAPVPVVSPTPPELPHLDLDATAMRDPTGAVRHSLFSGEERTWLSFSSLGPAPKPDRHAIMAAHQHASSPPNFNLQDAIEVRPALSAHQTWLVLQNVDRAFFRKYGSAVARGTLKLGVVHESSSVKILGRHVTVRRWHRAVWFEDECEHFKDPLAGVAVCRGRGPCSLELHEFVRVNEAAFDKVPGPVKRALGYYKYVKGDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG60</accession>
    <name>K1VG60_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vps72/YL1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG60"/>
    <dbReference type="STRING" id="1220162.K1VG60"/>
    <dbReference type="eggNOG" id="KOG2897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371397_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG60"/>
    <dbReference type="OMA" id="PVISYWS"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="749" mass="81556" checksum="FA42906B547440CA" modified="2012-11-28" version="1">MYETVTQGRAKRSTAGNRMRELLEKAHQEDQKDALFEEDPEDAEFEAPADVRDVYLEDFADTDEELDDEEAEERQLRREERKKAKAKAGFNPLQPKTVRMGQPTVQMPSAEELAILGPNIDVSKMAPSTLILEIRRRKREAKREQRSEQRRSNLRASTLKTEADVIERERQEKIEKQNSRKGRKAQHVTGEIRGARPMTQAELIAAALEEEERNKEALTDWLKKEEERRELRRVGRKRVRGPRWTWVSRTVGRLVEVVEDETTAVPTPAPRDSTAPVTEDRPSATPATERNADEKGPSVEASASAKDVNDAQPSSATEQHEPSTASTDAASRPAEEGAPAAQSANSEEATKDETAKTDEASSPATAPTSKDVDQSSPAKEAASKASGPAAPEGTSDGEPKADAVASADVTMSEATAAQEVPDTASASEPPVPDAPKDATSAQASTDQSAKADEPKAAEPSGKNESETSKDGLPKADESVKPNASKDGEPSPQLAEAKTDAPAKTDEPSKADPITDAAKKDEAKEDEKKDEAPTGPYTRNYLILSQVPGGLPAELKLILGDHVDWSDVKVVPARNRPITDRKRPRDPLTGTPAPYRHPGSMVPYSSTESYATLQAILANRYVFTPEGIWAGGEADMAAEGAEEIPGWKEACARGWLDGKRIPEDEPEPEPVEEPEEEAEEEEVEEEEEEPQETKRGAKRRKTEPAKSKAKGKGRAKATAKSKPKAKPKPKAKAKSTPKAAPKKAAPKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGW8</accession>
    <name>K1VGW8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000351">
        <property type="protein sequence ID" value="EKD00061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGW8"/>
    <dbReference type="HOGENOM" id="CLU_994624_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGW8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="280" mass="30348" checksum="C070471160C38B2C" modified="2012-11-28" version="1">MASNDGNPPPCGAPQPYPSAAFGLTPSASDASSPSPTASTTSTIKVTAIPPVYPQPAKLQSAPHRQCGLSASEATPLQLTVDALKAHDKRCERHSVRQAIRYGQRPAHKPKSKPPKSHVIRRLEGEFRDAAAETIYGLESALSAMQDQHARLEVVNARLHAQVTELQSRNHILAGTITYERAARHHAESKAIVQERAMQAEVDYLRRSLASTGKEGLRSHRTISPKAQPETTQTVVRPQLPPPWHPGNDDGVDHGDIYSDTLAAFLTHGAMPTSNWTTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHJ5</accession>
    <name>K1VHJ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000344">
        <property type="protein sequence ID" value="EKD00316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHJ5"/>
    <dbReference type="FunCoup" id="K1VHJ5">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHJ5"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="InParanoid" id="K1VHJ5"/>
    <dbReference type="OMA" id="RQIPIYK"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852166" evidence="1">
        <location>
            <begin position="25"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="239" mass="26316" checksum="B10D02FEC0F6B70E" modified="2012-11-28" version="1">MAQIVAKPFRLALLQLAGLNATKANNISVARAAVKKAAESKPKPDLIVLPEIWNSPYAVTAFEQYSERVPNVKNGKEEPAKGEEGESITALREMARDNGVWLIGGSIPEKEDGTNNIYNTLTAYNPEGEMVAKHRKVHLFDIDIPGRQKFKESDSLSPGMTLNSFEAPFGKIGVGICYDIYGHSSVVNPLGDVMEEADENEAIVYADIDPEMLATTRRNLPVTIQRRFDVYPDVANPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHY0</accession>
    <name>K1VHY0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">A1Q2_02051</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHY0"/>
    <dbReference type="FunCoup" id="K1VHY0">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHY0"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028295_1_1_1"/>
    <dbReference type="InParanoid" id="K1VHY0"/>
    <dbReference type="OMA" id="LESKCHT"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852148" description="triacylglycerol lipase" evidence="20">
        <location>
            <begin position="21"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="21">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="394"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EKD03705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="483" mass="52521" checksum="8CF1A94FBBDEE855" modified="2012-11-28" version="1">MWIPFAAQLSLLVSQRVLDSAPNDESSGSVSLAPRHAHVASYNQSQPLLFYSNPNTFSINSDPLVLKTRKAKIRRARSRPPHMLSWARSVKDAREGRVNASGWIAPNINTAALPFGAYAADGDGGDGDWDDVEVDAPDVTDRQTLLTLAKMSSNAYTTPDESNWWPLSKWNNGTGYGWEPDADGLRGHIGTSAGVLGSGGPTAKNDKFNDNLMFSCCCARVDFSWSTVCDCYAGSYKCEQQCVENALVEESVYASVGTNLYNNVTYMYPDANIWLTGHSLGGSLSALIGSAFGAPAVGFEAPGDRLPARRLHLPGPPAIPPELSGITHVYHTADPIPMGACTGAYSGCYAAGFALESKCHTGETILYDTVTVKGWSVDVRTHRISEVINRVLADPWPVGDDDGDGDKKPKEPPKPGPGDGDDDDDDDDDDIPGWPWSNWWGWGNKPRTKKPKWNPHGGVPKAKPEEDCVDCYKWEFGDHWDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2024-01-24" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIE4</accession>
    <name>K1VIE4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIE4"/>
    <dbReference type="HOGENOM" id="CLU_268341_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIE4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="395"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="803"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1224" mass="140453" checksum="D8D0E2B224643F43" modified="2012-11-28" version="1">MSHEGVINAALFPKIIQRIFDVADADSLRALSRANRSFRREARWRLRPLEHFDLHVAKVPEAINRNVTGAFLYELSGPGVRVLADGKHFHWGHAGDAWEEFKRATSLLPPVLWDLEADWEMVRSGDNFEAGAAYERPKGIEQVNCIEEIPQKDLDALKHARVLDVHYPLGIPESFLTQRLLPRLHTIRYPAAQSIEAHKALIHALPVQRIVIFDNPGRVIKRGYRNEVLEICSPRTTKLVIHQSTGSWRTGDIFPPSPPPSDGLKEVAYIFNRWTPMENMSGTSSLNSCQWFAIWALKRGMKAYVVGADDYNPDSVRDRLQPEPVIERCLKGMILPYVSSSQFADTEMSEFAESQMGLRSLRFVTRDEYRDIVGQEDFEIETDIDYYKVIDAAFFPHIVQEVFDYADFDTLCTLSLVNRSFHRAATRRLRPYKHFELLTADVPESIHKDRTAWYLYELKGIGVCVLADAMHFHWGLASADHHDFEGIHTPIPESERGYPIIVEYYDAEEEVYVCPKEDGRVDCLEEIPATDMFTLKRAQVVDIRYPLGKDEAFLNICLMPHLHTARFPAVAPPMIQESLSEPPAVERVVFFDNPGRWFKPVPYNKDFQLCSDRTAKVVIHQMNGRKGRDKDAMCPPSPMPPSKRLQELTYVFTPWGLDKNEDGARSLDRFLFLMVWAALEHNVKVTVVGVQDIDPAIFRDERLRIAPEPPGGYTKDKPDEYYDPENYKSITTGDDIVAYFKQKLAKVARIAKSAEYAEKAQRNVTFLTREAYRDSIGEEDFAIETDVDYHKRHFALVIDAAFFPHIVEEIFKHADIEALRVLSRVSRSFRSAARRRLLPLEHFNLEVVHESNDLRRVSGESTRYAVIGKDVQLRADVRLFDSGVKALELYQTLGPELFNWGYDSDGEESIDHESGCSDWDYPTQPPPGWEDSFDGIPQEKRDALQRARVLDIDWSLKQLEASLTDRLMPHIHTVRFEPVDNSCPLPIEPYAFPRAQRTVFLDHLYSDNLDNLLWRPLLFAVADELDFDQSGKFALCSPDTIKMVVNQVQGFKYGASEKMFPPTPRPTAQLKRISYVFKHWDVDPQEDQSSSLDLFVKFTVWAAGHGIAVTVVGAEELDPLLIVQRREKTAKGREKIFARGEQNSISRKAIVQVLKQEITKCAADVEAHPSEGMPKGRLGQKMRKNVTFISREQYRDMIGEEDFSIETEMYYFDSYPLNHWLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIF1</accession>
    <name>K1VIF1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2 9">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 9"/>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIF1"/>
    <dbReference type="FunCoup" id="K1VIF1">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIF1"/>
    <dbReference type="eggNOG" id="KOG2915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_4_0_1"/>
    <dbReference type="InParanoid" id="K1VIF1"/>
    <dbReference type="OMA" id="RITRICC"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14801">
        <property type="entry name" value="TrmI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="12">
        <location>
            <begin position="69"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="391" mass="42578" checksum="3B81E02A2C2FF4CB" modified="2012-11-28" version="1">MTTVSTMTTEGKSMFHSRVHIEAGDLVILFMSRDNMTAITVTPGASFHNKFGMYKHDDMIGMKYGSKSGYLHLLRPTPELWTLSLPHRTQILYMPDIAYITMRLGVRVGGRVIEAGTGSGSMTHSLSRAVGPSGHVHSFEYHKARFEKAGNVCKDGFGDVENVEAIFLDLPAPWEAIPFAVKNLNVTRICCFSPCIEQVLKTATTLREEGFTDVSTVEVLTRTYDLAAAPPPHSHALQDVSSIADKLRDHERRKEERRVIQMKNARAKARAMKEKAEREAAGAPEPSTEEGKMDVSEEDAINAAAAAGRSARTKARGETEPDAAEPGAESAASAAGTKEEAATPAKPVSGEPDVAWSRMTLTKPSPEMRGHTSYLTFATLYPAAIRAEMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIG9</accession>
    <name>K1VIG9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIG9"/>
    <dbReference type="STRING" id="1220162.K1VIG9"/>
    <dbReference type="eggNOG" id="ENOG502S97I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2499472_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIG9"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="6">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="86" mass="9105" checksum="BEFC8259D48E1EE9" modified="2012-11-28" version="1">MPETDQAIALLLAYGASTATTLLPVLNAVLTDPYSKPPLSTTELGMLLSSYVPFLVIPLAMAVDMGARLCNIVSRVQAADARKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ71</accession>
    <name>K1VJ71_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone acetylation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ71"/>
    <dbReference type="FunCoup" id="K1VJ71">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ71"/>
    <dbReference type="eggNOG" id="KOG4140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_706005_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ71"/>
    <dbReference type="OMA" id="RIGMASK"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="3">
        <location>
            <begin position="177"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="399" mass="44046" checksum="4A6CD2CB56D53769" modified="2012-11-28" version="1">MLKLRARSSPDRPAFSFETSPPPSEDAPGPFPRPPGEFLPERDMHMYGAQPVDGEQFEPGRSLVRCPRCSRTVLEWASADHKRICSHVLDGTPLLAKKVKGDKRVDGKKRRASEGESDASPSKLKRQRMLEDIDDEDLTSVKGLKKSEIKKLLKERERLRKRAAKEQERAAIAERKRQRALNPLDYDRQCGVINDKGLPCSRSLTCKTHTVGAKRAVQGRTRPYDELYIEWQRTHNPNFKEPAPKKEGNKLALKAVTAQKKRRALADEDGLRFDEDGAREMEELIRATRICGDRVKNVSSALGNGFTLPPSAPAAPKGAPAASAAAAPAPPRPRPAQTPFPSVWRTTTYEQLNMGDLLTKALAARPRPQPQLPARIGMASKPGPVSLVPPPAPQQGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJM9</accession>
    <name>K1VJM9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJM9"/>
    <dbReference type="eggNOG" id="ENOG502RXXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477502_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJM9"/>
    <dbReference type="OrthoDB" id="2524557at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="61690" checksum="33091485975863C0" modified="2012-11-28" version="1">MAANPSHLLISRNPRSPAHPQLASTLTTSPYLFPFPTDDSTLPHVSGGERNAPRHTRSQSTPAFDLDLEDDTEPLEIHPTFRRDAEFPGRVLVIVGGYEFWCHKEVLWFASPFFNALLKGPWTETGGKGHQAHGHGRSDSHHSHRSHHSHTRSHSHSIIPSSTSHVPSSTPPDPEPAAEQDHDVAAPDTDTLSLPGKEDEQKGSVYLDAQDGPSVAEILAELRNLPEPPTASEGGASAANRLSMFGANPAPPHPATQQPFQLPEADERKKAASPLSSLSSSGVLKPKPKRASTQSGSISTPVRPCSAPAGERHRDVDCVVELKEESPEAFQDFLYWAYPHLDCKATWTNVEGLDQAVRAVPHDTRLRTARHGHSARRAAWQCRAVQGGEPVPPRPADVGPGGVREPQRDDAVEAEQATDVVPGTSAETRHDRREEGVHLQAGLPRSEQVPNAARREVETSILGGVAVWSAAGERRLPLSTTAGDLSHQPQPGHAAPAVSDECEELGQHAYAYGIELTAVFDRMFQPKVAFGLVTPGTEKVSCWLRFSADDSTGFTSLSTNITLDGLRSSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJP9</accession>
    <name>K1VJP9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJP9"/>
    <dbReference type="STRING" id="1220162.K1VJP9"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="InParanoid" id="K1VJP9"/>
    <dbReference type="OMA" id="RYLYLYC"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="526" mass="57910" checksum="D2E68BA0A78C5580" modified="2012-11-28" version="1">MSVPEYTETPLDEIDLTYDRLNATFHSFKTLPIEYRLYNLKQLAFLIQDNIEAIYAALHKDLSKEPLDIDVGDVWPILNEIELAVRRLPEWMADEKATRDSVLAFKLSRPHVRRQPKGVSLIIGAWNYPFQLTLSPLVGAISAGCPAIIKCSEHSPASAALIAELLPRYLDPEAYAVVNGAIPQSTALLKKRWGHILYTGNGAVGKIVATAAAKTLTPSTLELGGKSPTIVASDANITMIARRMMSIKQLNIGQMCADPSLDEFYPKGSERSLIGKHGQAAAFRNAGDYDRIEGIIDEAQKGGKLIYRGEEDKPNRRMGISLVRLNKDGAGETGILVEDEIWGPVLPIIPVDDVDAAIEYVNARPTPLALYVCSAFRSTFEHVINRTLSGSAIWNDFSFAPVVRTLPFGGVGESGWGSYHGENGFLAFSHRKAVLEMPGWMEIAQKSRYPNNYVEGTHKRMKMVMTAPLGFSRPVSVEHERRALERRRNRRTFYLGVLLVLVGAAAGLGGRRIASFLGGLKAKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKD6</accession>
    <name>K1VKD6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKD6"/>
    <dbReference type="HOGENOM" id="CLU_804571_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKD6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40832" checksum="29B27A98038C32A4" modified="2012-11-28" version="1">MSTIDHSYYPHIIDLIWDHLDYEDQVVARAVCSEWTARADARLLHLVISCPQGKPPHVYDVSTRDLSRPNVPPAWLTETSRTLHRRPTRHPTHPVNEPGAHDLQRQRKLAAHFKANALDAVEVIDFVGFDLRSHAPLALGRNPFIRSILKEYGVVRWFGSPPDLTDLGGPYDYYNDPEEVELPPALVDVYMFSFQSNAPVSVLKWKDLVNRKRLQIIDYVCYSDPTGASPSLGPLIDVDSPSRSLCPVNIIFHNRIPPSYQSLPALDPGIVAAYGELVLGGNVVAIVGLEEFLNPKELRKFIKIVDREVIRGRWIDDDDGGQTWWVPNQSCLEDLCYWTHEEYRQHVGEETYRIRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKG1</accession>
    <name>K1VKG1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKG1"/>
    <dbReference type="STRING" id="1220162.K1VKG1"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1349743_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKG1"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="203" mass="22663" checksum="C624431D36879D96" modified="2012-11-28" version="1">MADKLDLDQILEFAKDTARKLIQDGQKRRMQENASQDQKINSVDFAADTSIGEETYDGQKITDDPTWIAAWRAALAKHQPDRRHDKLRQAGRRRRVQPLPEPDVLCRRGPGCVRRQHQAPAHEEGSERPRRGSVSSPSHRRANISVAVEYGSSRRDPAMSNKLNSFKKLTSDKKDGGKMVHSLRSVGSAALNICMVAAGDIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKJ2</accession>
    <name>K1VKJ2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKJ2"/>
    <dbReference type="HOGENOM" id="CLU_991075_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKJ2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="2">
        <location>
            <begin position="120"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="281" mass="29814" checksum="18ADA940A45A8D72" modified="2012-11-28" version="1">MGKAVDTTSKTTRVESGPAAIDGGSVDMPPSYDAPPYEDNAGSSEAAPATQPPPPAPVSRPAPPAQAQQTGATAVAPSKAFNRRIPPPGAQRAVAPLTITRNDKSIKEDYVVSIGENKRGPDVRLETNDARIDSFIYLTGSVPRAAVVEAVTDDSSIRLRVQREEGQAVEIHAKTNDTGGMFELTPGRVHLWLPHGFDGLVTARVKGGKAELSPSLRNVAVLWPGASEKHTQTWAIRLGKDRSTTDEPGPDRAYAQTKDAGIRIYADTDDEAGEGDKCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKL0</accession>
    <name>K1VKL0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GCN5-related N-acetyltransferase Rv2170-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKL0"/>
    <dbReference type="HOGENOM" id="CLU_821800_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKL0"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCN5-related N-acetyltransferase Rv2170-like" evidence="1">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="37463" checksum="13C6462BDA061BE7" modified="2012-11-28" version="1">MAATLQLYEHDPASLLPLLTKFLPHTQAVLGAIVSCPPPGQTPQSALDAPPLETMWASFPPGNLPSDSDTDWLVTLALPAPSEQIRIWHRAEVELNNEEIERVKQIEGSVVSTEALREAESKGGNEDAAAQVIEARRIMREKYPAHFVMGQLNAAWEPALRHALMAPGRGICRVFLAPEELPSTGLDEERLRELGLKLDTTRVGDEGEYHPPKYILARSKYTTLVRPIDGGDPVCWVLTHADGSLGALYTLPEWRRKGLAKIVVAERLRAMAESNSEGSGEGDRARAEASRRLRANLQVEEHNEASEALWTGLGWEPAWCVAWVYSQEDQEKYRSVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKN8</accession>
    <name>K1VKN8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKN8"/>
    <dbReference type="STRING" id="1220162.K1VKN8"/>
    <dbReference type="eggNOG" id="KOG4379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021382_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKN8"/>
    <dbReference type="OMA" id="DTRFVHH"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="295"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="635" mass="68471" checksum="6314A61BE5593809" modified="2012-11-28" version="1">MSASKSRPAELFTPDRALLNPRFETYRLQSLDPSAARGHRLPGEGATQSRVGYGKQQLGFKEVRSRISWDHLDTRGGRGVYVDTEWKVVGFELDPVSSGEEHAEYPRALALSDTLWAVSSGSGSIYVLEVSPPGSPFAGKFIARYDLDSPSLLYAAHGDGSSFRLLLTRAVVQESSGSKYAPRTATFDLFEVSIDPSHTNDIDAGEKLQPEWELTGGDLPLWAAWAEGGWVVLSEEAFGPRPEAREETDAERAAREHKEKKAKLGLGAHLPTAEQTPADTPPPEAEAMDVDTEQPKQYPFHWTQDQGSVTITIPLSSGTPRDAISVDFTPSSVSVSVKAPGLSVPLFAFLSAGAHTFWSEVAQSTWTYEADEGRLTLELEKQPGDARWPSVFIPDDSDDDDVPETFSPAALAAIRESFGKVQTRTDESMPETNPTIPALLREQLDFDEDDDFAERTEGAFSDLSAGSVGRNVLFGSIVAGQAVWSRQPAAVLSLPLLTTEPDLPAGQGVIVRNAVDGLLIAPTPDGWKHEGTNPALAFVMSSKRDLRLVRHATRKEEGHAASLVLAFDAGSGTGQGNAYLYWPPKKGEDTARQGVLGVSGGDRGALLGVGEVVVGERRIAVALCEKSLVVLDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL35</accession>
    <name>K1VL35_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL35"/>
    <dbReference type="HOGENOM" id="CLU_687329_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL35"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="401" mass="44729" checksum="AAE0B8C874D4E2C8" modified="2012-11-28" version="1">MWFSTTLSSIHHLPATMSQPTGATIEAEYKCDLIYPTWKWPPDHVLPNPFHIKARRVTATYIVTVLGLVQALCLEWGLELALLHNIALRILDFFRGPYTMGIPKEQRDFCPDCQAAGTLCVRCATRTTHLDPTHQCYWKPDPQYPNVPPRADTPSPPPRGPASDIGPGPCKRHKASDSVSSDRPMPVYSRFSPGIYSDDFVAACDNADATSEAAPAPRTVTSETALAPHAVTNTAKNDNTAKDENAATPESEEWTIPWTRTGRRGWGPRQLHVNWSDVLASPDHLNVVRRMCSLLVNFVFPDQAAADHWTDNVRRWVPAYRVAPVYKSIEDKSGPYQSYYPRRLNAHADMSFQGPRIAIEDRPTRSDIHPGACNADPEAGVGRPLGCITWLEKFPDPFQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL85</accession>
    <name>K1VL85_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000351">
        <property type="protein sequence ID" value="EKD00042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL85"/>
    <dbReference type="STRING" id="1220162.K1VL85"/>
    <dbReference type="HOGENOM" id="CLU_392863_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL85"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="702" mass="76359" checksum="26D3A49FA6DFA885" modified="2012-11-28" version="1">MSRATRLRHFSTGSASFVVTFPVDDLELATSWNQTASSGTSARSRSTVSWPARRSAITAFPALIPRPTLVRDAVAARVGEEGPAYMFYTGCTIVGTPVSPVADELAPAAAMRAPTEDKKQVLDGLTKRYRDLDAARTAAAATGSLVAVVKAVCEARSERIVTEQELARLDPVKNDLINFARDPFSALPPSYATYVATVPVDKLDEAPAGEPDGLTWYERQITFGGFAELLARLDDAIATFPALIPRLTPVRGAVAARVGEQGPVYMFNSGCTIAGTPVSRATKGPGSAQQLITSLFDLWQVKADVYRVALEPVEIGTFEYRGERQLQLVEHCLISTRFPHNLNSAPGGFAHDYRVDLHPPCPLSESLREPAPAAKFEAVRRHLEGMYAAYASRRPTATTIDPDALAHQVDAATPRFLARGRPLVVAIGKDATREEYNGANPDIGYRQRLSGPGSQATNAALLQQHNVDAAMATLDQKLAILPPFVDLFTDPDFHFWLWSLIFLRRYFSVIGWPSVVWAVSGKVAAAFLDGDLAAVAEIENGQAFNDCREHVPAAPAETAPKKAVKMVDSAGHAVICDLGHGHLAIVLVNYDRGVLKYDPQPADNRRLGAYKRALCGTAIRPPSAPSTSFTTLGRLPFPLICVQSGESCVRGETTQHPIARWIHQVNRGYDPGLRVSRRYQQFHHQRRTARLILKANNNKGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLG2</accession>
    <name>K1VLG2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000348">
        <property type="protein sequence ID" value="EKD00122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLG2"/>
    <dbReference type="HOGENOM" id="CLU_832054_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLG2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37771" checksum="A4C37D50F274AB4C" modified="2012-11-28" version="1">MLTRDKTRKKAYAASVRCIHLGGSMVGLGPWDWVTLLSFFPNLTKVTCVCFEIDFKSISRKPADMLNRTLTITSMDRALLGDLQTISQSGWGLMSRLKVDAYWPPPSDFPRDCNGHPQIPEMFFMPLDVLHLPNFWINELWLVILRYRKAAGIPLSLLHWRLGQNAADMGSVAAVVPPGLRILILDSACDYPIDWMLDAITTSLDSRSFPSLEVLVLNILFSAGVTDNVNPLDQMRWFGEGDWASVTLPPTLRIVLNLTIFDMHDDPRTDDGYYEEQMLQSLPLSWLRKMRQRLGSENRITVTTTRDDDMRTFPLATPDIATSLQQILHAGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM01</accession>
    <name>K1VM01_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation diffusion facilitator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM01"/>
    <dbReference type="STRING" id="1220162.K1VM01"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_10_0_1"/>
    <dbReference type="InParanoid" id="K1VM01"/>
    <dbReference type="OMA" id="VECYHIG"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000011">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.174, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="215"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="351"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="481" mass="52444" checksum="8E5D044FFC049A3C" modified="2012-11-28" version="1">MSSPKSVLGGGFNPYGSNPGLGYTKPRSGTSSPALPPGSPVTLPPHLIRQRSRSPGRVTMSGLEPLTANDPGSFARHRLRRGLSCTDVHLLDIISPEERSVTDFMGVPLTESQINRQPRKNLDVIHGHYQEVDELLNGDLIRVIADSFRSNKRTYTVMSDLNEHPSHSRWAFINGGESGEEAGEDTPLIYTREEQRQRIASLALNGTSWAIGIPTDRHKYPAGKRRFEPLGVLIFSVVMIASFVQVFIEALQRTINVIRTGHGEPADLSNIGIATMLATIGVKSVLWAWCSRIPSSGVQALAQDAENDVWLNVVSLSFPKIGSPYLDPIGGIVSDPNVHLPDGSVSGRTASPDQYARILYLVTRFNPVLEISDVECYHIGDDLTIEVDVILPHDTSLHFAHDVGETIQCMLENLDGVLRAYVHCDYSSKNPAQHTARKKVAYPVPPRSPTGYESTLSGSATPKAPTPLSAPRITTQSPTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM50</accession>
    <name>K1VM50_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000402">
        <property type="protein sequence ID" value="EKC97802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM50"/>
    <dbReference type="STRING" id="1220162.K1VM50"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="K1VM50"/>
    <dbReference type="OMA" id="DAVFPGM"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="29931" checksum="4A9C11D2321BA3B5" modified="2012-11-28" version="1">MAPKDMAPEVMPELGVDTLFNLRGKVALVTGGATGIGRMIAAGYVRNGCKVYIASRKLADLQRVADSLNPVGKETGGSCHAIQADVGDKAGCDALAAEIAKRETSLDILVNNSGLSWGAPLIDFPEKNGWDKTFALNVKAQFYLTVALLPLLEKDKTNIRPATVINIASVAAISAQAEGALSAPGSGTYSYQPSKAASLHLTKVLATSLAPKHVNVNVILPGVFPSRMTSFGLQNSEDALVANQPTGRVGTSEDMAGTALFLASRAGAHCTGTAITVDGGSVLGRTGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMC4</accession>
    <name>K1VMC4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMC4"/>
    <dbReference type="FunCoup" id="K1VMC4">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMC4"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="K1VMC4"/>
    <dbReference type="OMA" id="IGRFKEM"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="441"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="547" mass="59192" checksum="90D17547CA346A7F" modified="2012-11-28" version="1">MPKQIIWKSTIPAPELPESSLIQYLIGGAGQTPLPQFDDSLPAFIDGFTGKALTRGQLKDGALRLAGALGKLGLGRGSTVCIFAPNSVNWARAAFGAMAAGVTISPANAAYAAKEIAYQINNSDSKLLFIDPVLLPVYEEAQSQIENKLDASRVVLLCTPEQKPKGSKYRTIDEVIATSQPVPFATAKGNEIHDTAWLCYSSGTTGLPKGVMTTHYNMTSQLQAVNKAYQSLESGKDTVLGILPFSHVYGLTVVLLQPLTVGVPVVVLPKFDEIPVLSAIQKFKITHGLIVPPILIVLLHSQNVKNYDLSSLAFNKIHPHISLTQGYGMTETSPVITTMTSEHSASHPGYVGTLIPTFEARLVRGEGEDDAGIGERGELWVRSPSVMKGYFKNQKATDGTMSGEWYKTGDVLVRDADGWLKVVDRVKELIKYKGFQVPPAELEALLLQHEKVVDSGVVGVWEESQATELPRAYIVAKPGLLKTPADKAKLEAEVSAWVASKVANHKKLRGGCIVIEAIPKSPSGKILRKDLRVRAEGERAKETRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VME9</accession>
    <name>K1VME9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000107">
        <property type="protein sequence ID" value="EKD05355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VME9"/>
    <dbReference type="HOGENOM" id="CLU_1107762_0_0_1"/>
    <dbReference type="InParanoid" id="K1VME9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="251" mass="27678" checksum="074508C31D0FAFFF" modified="2012-11-28" version="1">MELLAEEVCGYPQTSQRGSEQGSSDERPTEPVNDKTRPIGNYTAELARSLQLDSYLQLSDLVPSRPTLGQGLTVVGITTEIPTEIPTEIPNESNLPKQLEHWSENGSNRTSVLHASPAATEGLKQSESVWWESPLKFPPRFPLRFRPRFPMNPTGQNTWNPGQRMAQIEPVCCMQPQLQLRDGISPVGITTEIATEIPTEIPTEIATQIPSESKLPQQLEPWSENGANRTSMMHASPAATGGWHQSGGNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMF5</accession>
    <name>K1VMF5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Formin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMF5"/>
    <dbReference type="STRING" id="1220162.K1VMF5"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065002_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMF5"/>
    <dbReference type="OMA" id="KSAPRYW"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32339" checksum="7A33C7462FA5D656" modified="2012-11-28" version="1">MAEYWVSKKQYWCKYCNIFVRDDAPHQGNKERFIRDLYKGGERDKREKAAHAAEIARIEAAASAAHSSRDGGVYTGRPIQQAAPAPVKRAKPSGDKWSNYSSAADLGLAPGEEGPSSYEIEQMVRGRTTKVGEWEEVVVPSPSAEGGADGGEKRKAEEDPEDLREFKIQQKKHADPYDDDDWDPAALTKLKFKSKEKKIGEKEPEVKEEQNGEGSRAGPSAWAKAEVKTEPREDVKVEHTEASEVKQEPDVKTEAGQPEPPVKPEPAEPPAPAPSAGGSLFKKRRPPPSSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMN4</accession>
    <name>K1VMN4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMN4"/>
    <dbReference type="HOGENOM" id="CLU_1856712_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMN4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854246" evidence="2">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="138" mass="14580" checksum="562295D8AEB3B2FF" modified="2012-11-28" version="1">MHERNVMVIAAIRPLLARELALPLLLCPSSFEQVERVSTAAPQVDPSRILFAHLHPSPAPDILWVVPIRAQLLRPLALGGIAPVSPPAAHLYAVLGYGLGDSAAVMEGDREVVGPAPESGVDWGGEKDEGEGNVKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMQ5</accession>
    <name>K1VMQ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenosylhomocysteinase</fullName>
            <ecNumber evidence="6">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="7">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMQ5"/>
    <dbReference type="FunCoup" id="K1VMQ5">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMQ5"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="InParanoid" id="K1VMQ5"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="8">
        <location>
            <begin position="158"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="402" mass="44498" checksum="3A34AC487E86C7CB" modified="2012-11-28" version="1">MAPQQIKFKVADESLAAFGRKEIELAEHEMPGLMEIRRIHGPKQPLKGARIAGCLHIPPSSSRPSSLSGETEEEYLWCIEQTLTAFPDGKPLNMILDDGGDLTTLVHEKFPQYLDGIYGVSEETTTGVHHLYRAAKEGKLKLAAINVNDSVTKSKFDNYYGCRESLVDGIKRATDVMIAGKVAVVAGFGDVGKGCAESLRSYGARVLVTEIDPINALQAVINGYEVTTMEDAAPRANIFVTTTGNRDIITGKHFEVMPEDAIVCNIGHFDIEIDVAWIKENAKECVNIKPQVDRFTMPSGRHVILLAEGRLVNLGCATGHPSFVMSCSFANQTLAQIALWEDRDGDRYQRGRVYTIDKRLDEEVARNHLATLGVKLTTLTKTQSEYLDIPVEGPYKPEHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMU8</accession>
    <name>K1VMU8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMU8"/>
    <dbReference type="FunCoup" id="K1VMU8">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMU8"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_2_1_1"/>
    <dbReference type="InParanoid" id="K1VMU8"/>
    <dbReference type="OMA" id="MSYQQER"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="35985" checksum="7DADAD97C7855221" modified="2012-11-28" version="1">MWADTVIKKDKSPVTVADLSAQALISLHLIPAFPKDEIIGEEDTSELRRNDALCDKVVSLVNEGFTRVSGPMQNDTFSKDQILDAIDKGSAAGGPKGRFWTIVSYLSLIELTPQDPVDGTSGFIRHQQYAVCLALIVDGEVELGVIGCPNLGPEPAKIGEEVVPNGKGVLMVAVRGEGSYSRPLTEDKYTRLTLPPMPPADNPLTFLESVEAGHSAHGIQKRIGELLGVQRPSLRMDSQAKYACLARGEGGVYLRIPTKYSGGKEYQEKVWDHASGALLIAESGGVCSDMRGKPLDFTQGRTLKANEGIVAAGKEMHEKAVKAVQEAVGEAGYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN00</accession>
    <name>K1VN00_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN00"/>
    <dbReference type="HOGENOM" id="CLU_529124_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN00"/>
    <dbReference type="OrthoDB" id="10583837at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="515" mass="56701" checksum="B1BB092373BAEB15" modified="2012-11-28" version="1">MGQSIDTATVPLTDESDDELAAPAGSEQPSTEASDKPSQATSATTPSSASAVNKLMAIPHIVTTILRHARQDRPSLARLMRTNRNLYAAAGPILYHTAVIWEENIDAFFEGSFKRCFCTDCKKSMEAKWGVDHATGELNAFGELTARPHGYGKYTNPAPRAASANETAAAAEVSKPKKTKGGNNKKKNKMKKKAQQNKAVKEDAATSPLDSKDSTSNKGKYSVPHSRKPVIPGEPKSTLPLSKRQLLAHVRVLTLSGHHESACEGYAPHAAKYLVNLEILRVVEMPHTPFTTFHICENIPGGSCPLIDNLAPRKLVVRNISGLRLPFPPSWTANPKTKEIVFVLPTESAAYSGKDFNEATTLRVVFWDGWDRSLCDHPLTRTCSPEQAADLRKRNPPRPIHVDDVASILHGFARTRRTKLFEMRRPRLEIYGLGSVQLSTYSKSPLVDEYKAANPGKAVDLHTVAKLKAMRMEVSMAVLPQGGPPIMLGPCFDITWFTLENYKRKKFAAEISEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPE2</accession>
    <name>K1VPE2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPE2"/>
    <dbReference type="STRING" id="1220162.K1VPE2"/>
    <dbReference type="eggNOG" id="KOG2068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354953_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPE2"/>
    <dbReference type="OMA" id="LHEWGGE"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="714"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="791" mass="84933" checksum="3422D59CCF9EA084" modified="2012-11-28" version="1">MPTVHPLPVNPTTGQQPLGALRGSISSGGQSSSGGVNREVLKQLQDVAWSDEEDDPDCMVCAEPLDLSDQNFKPCQCGLQICQFCYNKLLRDDPRCPGCRRKYDAASVVFQPVDFDEAKEKKARRAKITKQLDTMGRRHFLDTRIVMKNSVYVVGMKIPGSSPEESVSILRSNEYFGQYGKIARLYLKDRTAISSVTPGPDSDTPATSTGIYIVYVRREDAARAISSLDGIPAPQGPPGQVLHASYGTARYCDAFLRGMKCDNAHCHNLHEWGGEGDCFTRTDLITALTRPAEYDARQKQSQIQPPPLSSKSAWPKPSHDDVDANTALPRSASWGMRPSPARPGSATGRPSPVGSSRPTKIQSTLIPLGRSSAAFPPPAPSPAPPVHQKKEKKPQNMTRVRSEASSAGSAGAVGSITTGSAHNSPKKKPVTVNITPHQPATSSSSTSTPTTKSAPPPPPGLAPPPGLGPSTTEKTKTKKEPTRTPTPPAAEEPTPPPAVTPESDKEKEKKEVQPEAGPSSQPATKPTKKDTEYQIHSPYPDFDDVFMEPNARDAGFSFSLGIDEDECKRLLALAHELGAFEPTEFDPLFEQLPKLGIPLTSLIALPRFDAISVGAYSGSFAPFAPSSPLETGSVPTSDEPSAEASSTSDADPAPRTASRFEFARRGSLASGSARSGSPFRGREDWGRAPSSNGYAPEEPRAPQHFHPALAQLNSGSGLSHSAHSAASERGSEYGYGQPPRPYQPSGYGSAYGSPQRETHYGVPPGYNEYQQQQQQQQQQVYGGVGYGQRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQG0</accession>
    <name>K1VQG0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQG0"/>
    <dbReference type="STRING" id="1220162.K1VQG0"/>
    <dbReference type="eggNOG" id="ENOG502QQPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031812_1_1_1"/>
    <dbReference type="InParanoid" id="K1VQG0"/>
    <dbReference type="OMA" id="HYAITDT"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="361" mass="39161" checksum="E601FDF1E428AC2F" modified="2012-11-28" version="1">MSVPECAQQKVDSVSDDLRKISLKVHENPELAWKEHTAHDALVDYLKGVSGVKVEEFEKYPTAFKATYSNGNGRTFALCSEYDALPEIGHGCGHNLIAVCGLGAFLAIKEAMDKGHVNGNLVLMGTPAEEGDAGKVRLMDIGAFVRTLSMTHLRVTFKGSPAHAGLAPWEGVNALDAAVLAYSAIGVLRQQIQPSCRASMLYLIRAPSAALVMDLKKKLTAAFEGAAMQTGCKAEITGGLLLKEMRNDVSLSIMGDMYDIPVRVATEECMGASSDFGNVTHAFPGCHPMFNIKSKNSNHTVEFTDASKSEQAHGEAMKHTTGMACTGIKFMTDDKFADKVKESWKDEMEKVKKEHESLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQG4</accession>
    <name>K1VQG4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQG4"/>
    <dbReference type="HOGENOM" id="CLU_1289763_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQG4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852349" evidence="2">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="214" mass="20894" checksum="158EB192BB255083" modified="2012-11-28" version="1">MRFSTAFGILFSLVTANATPLLVPRIDECNPGGGSHGGGAVIPSYCYSSVSLATSSVYASPSDMAPSSTSKCLPSTTSTYVTDPCNPGGGSHGGGAILPSYCYSSASASTSSAYVSPSNMAPSSTSKCLPSTTSTYVTDPCNPGGGSHGGGAVLPSYCFSSTTSVVTSAYASPSDQAPGTTSKCPSVSPSPTSSYNPGGGDHGGGAGSPMSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQS3</accession>
    <name>K1VQS3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein component of the large (60S) ribosomal subunit, Rpl2bp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000271">
        <property type="protein sequence ID" value="EKD02981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQS3"/>
    <dbReference type="FunCoup" id="K1VQS3">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQS3"/>
    <dbReference type="eggNOG" id="KOG2309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="InParanoid" id="K1VQS3"/>
    <dbReference type="OMA" id="HPYKFKM"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="251" mass="26988" checksum="F07F266987E9A68A" modified="2012-11-28" version="1">MGRVIRAQRKSGGIFKSHTHHNKNPARLRNLDFAEKNGYVRGVVREIIHDAGRGAPLATVVFRDPYRYKLRKETFIAAEGISTGSFIYAGKKAALSIGNVLPVGQCPEGTIIFNVEEKVGDRGALARTSGNYATIIGHNEDGKTRIRLPSGSKKTISSSARATIGVAAGGGRVDKPFLKAGRKYHAMRAKRNSWPRTRGVAMNPVDHPHGGGNHQHIGKASTLARDASAGQKVGLIAARRTGRKTGKVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRP7</accession>
    <name>K1VRP7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRP7"/>
    <dbReference type="eggNOG" id="ENOG502RB8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1230678_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRP7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="222" mass="24315" checksum="93E7D6816909976C" modified="2012-11-28" version="1">MNGAPPDPARDALLSMREALLAREQELMADGIGSMSMEERGPIATSPTTRSGKARAMECIRQGEAAHPANKMSLAQADPRPMGESLALGTRDFDNQTAARFANLGLQQQRPETPESPDQRAWQELRHQAQASHYARSHVDDPSNTFADRDAYSAAAVYASQEDDPGTGLPMDVARSRRDEGYDSDMRMDREEEEDAENEFSEGNDEYEGDGTNTMDAAPGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS15</accession>
    <name>K1VS15_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS15"/>
    <dbReference type="FunCoup" id="K1VS15">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS15"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS15"/>
    <dbReference type="OMA" id="AICAMRI"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="621"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="736" mass="79926" checksum="519584AE2E65BFF3" modified="2012-11-28" version="1">MYAVGLALCTFANIASEEMSRDLCNEIEKLLGSSNTYIRKKAALCALRIIRRVPDLMDHFSDKAKTLLQDRNHGVLLAGITLVTEMCDMDDEIAQQFRPAAPLLVKHLKSLVTTGFSIEHDVSGISDPFLQVKILRLLRVLGRGDVEASDTMNDILAQVATNTNSTKNVGNAILYETVLTVLEIEADSGLRVMAINILGKFLTNRDNNIRYVALNTLNKVVGIDTNSVQRHRNTILDCLRDGDISIRRRALELSYALINESNVRIMTRELLAFLEVADNEFKLGLTTQIWLAAERYAPNKRWHIDTALRALKSAGNYIREEILAAFLRLVAHTPELQFYTAQRLFTALSNDLSQESLTLAAVWILGEFGDVLLQGGSIDDGEDVKPVTDVAMVDLMETVLTSPYANTLVRQFVMTALAKLSVRFAETGSQSGAEQQRRINQIIANYSTNLELEIQQRSVEFGTLLNMGDVKMGVLERMPPPEIKATIMGTVSERRKVGTTRADKDTVVDLIGDDMSAPSGPSNGAPQQSLQSTQDLLADIFGSSDATPVTSPSAPAPAKSHAQDIMSLFDSSPATSSPAPTPAPAAAAGGSLFDLASTPSPPPTTRSPPPAPAAARPPQAPQLQSYTAYEKNGLKITLTPKVSAQPGVVQILARFTSASPVEGVNFQVAVPKLQMQAMSNQNVQPGATETQQLRVIAPPGAQIRLRLRVSYKKDGQPVQDQLDFSGFPPNLTSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSG8</accession>
    <name>K1VSG8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSG8"/>
    <dbReference type="FunCoup" id="K1VSG8">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSG8"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_0_2_1"/>
    <dbReference type="InParanoid" id="K1VSG8"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15777" checksum="9153502280187B16" modified="2012-11-28" version="1">MGKRKSSKKPVAKKTNEPLLTSSPCSARSTARSSRLRSTVGPPCRSSLTTDLSVAVDVYCDWVDACDEINQKAKPKPKIRQRSPEPAPRFTENEDEDEDEPPRRKISSRDYDSDSDDEDDRRARKVARRAYDDDDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT04</accession>
    <name>K1VT04_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multifunctional methyltransferase subunit TRM112-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT04"/>
    <dbReference type="FunCoup" id="K1VT04">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT04"/>
    <dbReference type="eggNOG" id="KOG1088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086140_2_0_1"/>
    <dbReference type="InParanoid" id="K1VT04"/>
    <dbReference type="OMA" id="DEMPEMW"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10554" checksum="08CA52A08AB654AB" modified="2012-11-28" version="1">MVRLITHNMLACHVRNCNTNNFPLAFSDVELVVRPAEANYDFLRRFLPKLDWAALVDTARSLGDESLPDEMPEMWDDEMLQKLHHVLLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT24</accession>
    <name>K1VT24_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT24"/>
    <dbReference type="STRING" id="1220162.K1VT24"/>
    <dbReference type="HOGENOM" id="CLU_2607719_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT24"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="79" mass="8714" checksum="C2D406D1F2A19A8D" modified="2012-11-28" version="1">MSAEFLRPGGTEGQYLYAEGTASKVGRRMAFTRIDFYNEKDQLVAFGSHTHAVLPESKPHEIVFSEDGEKAIPVAQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTC7</accession>
    <name>K1VTC7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTC7"/>
    <dbReference type="HOGENOM" id="CLU_2005505_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTC7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="124" mass="12871" checksum="C7F9FDF10945ACF8" modified="2012-11-28" version="1">MRGTPTSDESKYGTQPKAAGLPGTPSSRVPSPGGEKGARMGASPASPGPTDTRDSVPHRPLPSAPLGSLAACCAYYGSAHRRFDQRSSSKIEKTRATWQPLDLSRRPAPVGPGDPIPSGPVRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUJ9</accession>
    <name>K1VUJ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylglycerol lysyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUJ9"/>
    <dbReference type="STRING" id="1220162.K1VUJ9"/>
    <dbReference type="eggNOG" id="ENOG502S16U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467071_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUJ9"/>
    <dbReference type="OrthoDB" id="2595275at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051211">
        <property type="entry name" value="PG_lysyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34697:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Phosphatidylglycerol lysyltransferase C-terminal" evidence="7">
        <location>
            <begin position="244"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="584" mass="64394" checksum="B4DA3112F716ACB0" modified="2012-11-28" version="1">MVLIRQPEIADPLDKRFNQDPFDPANVNSLWEHPSLQHLSLEFLQEDAKTTPRFSMNVIPASATAPDRPKASSESPRQESLYSSPSLTASTPPLTREPSLASSSVELRSPSSSSLEESTSTSTPASSITTSKAAARAAKRRARREINKEKRRAEEEAKAKKADLQGWEIALDGLKHPISAKRELRARRESIEKFQVPADRQVATRSGAPVPATDFSLEHNVASALTEELVSQYGGWSITFSDPSYRIWISCGKNAAISYKHVKGMFHHYAIVFGDPVCSSDVKKDILDQFQTYCRARRWRLAMVGVGAETAAIASAARWSTIQFANEQVVNPQSNAILDGTNGKRMLFTVKKMAKDGVLRMYNPADGRDAVLEAYLQGVYDECYASKEVAKGEASAYSTKLRVFDLPYLQTYFYTVDSDERPNGMATLMTVSPGRYLLDPVVAIPTAPAGTTDFLTVAAMGWLRRAGAEHMTFGLEPQRVIGSIEGLRKHWHGATRRVNAAAFDGFGFAGKKMLHDKFHPDPSRTEPLYVVLASSHSMTQADGALAICAATHIRAGPVLSRLVPWSKNHSRLDQEPEQPTPERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUK7</accession>
    <name>K1VUK7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUK7"/>
    <dbReference type="HOGENOM" id="CLU_588188_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUK7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="465" mass="50510" checksum="8B21BC6C292168E5" modified="2012-11-28" version="1">MPNANRRPLSSTPVDSGADVPASILRTEVPTLLYEANDAAGSETFSAEVSDASSSEVSEGDARYEESTEVDESEDDDEGEESECEGRDPRLTAMALDLAMYRASLRPSSSASSHLFWNWPTLSGHASTGGEWTREVRLASEAIQAHRAAASSASGSISNLDSTAEAAQSHGANDSDADSDSDSESETPRESESARQRRILIERALAAREAQTAAERAELETWWRHNPMPSRTAYDHTYAYAAQVAREAMEADRSSRIQEEVIQAARRLERQARGVGVDTDGEADVEADVEADVEADVEADVEEREDAGEVAGERSWHTGRALEMVLSAARAGQLQVRGDTRPHMQYIGQASSVRHGQRLAHSAHSSHSAHSSHASTLYTFGLPSTSSTPVVSPPTVTYGAPSTQSQQQAHQQQRLLSLREARKATIDAANRRFWAERELGLFLLREARLEVDGGCQVLESGPMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUX0</accession>
    <name>K1VUX0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUX0"/>
    <dbReference type="HOGENOM" id="CLU_505465_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUX0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="539" mass="57740" checksum="722801C9158F5206" modified="2012-11-28" version="1">MIGTRWRRASNANLAANINNLTVDASSPVPSLLVPSPRTPTASSPRTPTSASSAMPRTPTSYQSSQPRPSMTRTESSRSSNSGEGSVYRGAAYAASTPRLSTSTSRSTWEMVDAASLPSACDRSDRNMQSIRTTRNFIFPLSEEHGPVSSVSEVEGRSGKLGFTGFVGAYEDEPVVVVELRIDSRKTVPIARSMGSKTPKEMVSTLDMVRSFGLMSEDTTVRQTTRKLEPERPERRSMIRHKNSIPQLQTERIPIPPPVALEAEETSPALSSAPTLGSSIASPITPSVVFVPSPPSPAMSQFPADDIAFPLPPTSMPTPQQQSQPKFRRTMSSCSNTLSTCSTTSSADMPTYDDQVPMYPRPPPRRERRTPASTSGSSFGYGSSIGGHSSNMSMGSSIAGSSLYHSDELESVGSKRLSQSSTEPTTPTTPTTPTSNNWTQTRVHRSPSHSHQRAPIFKRSMSFRPASGTSNGSASPGVSFTVLPASEATPLDTLGESPAMSPKFDDRRGSTLLGTNHGLYEANPSLTDIIAADHETHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW12</accession>
    <name>K1VW12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Retrotransposable element Tf2 protein type 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_04652</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000326">
        <property type="protein sequence ID" value="EKD01048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW12"/>
    <dbReference type="STRING" id="1220162.K1VW12"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_6_12_1"/>
    <dbReference type="InParanoid" id="K1VW12"/>
    <dbReference type="OMA" id="WNDEFIN"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="197"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="506"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD01048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="571" mass="65579" checksum="5D5513A06BAFEF31" modified="2012-11-28" version="1">MYFNTKRVLDRQQARWSVSLSRFDFSIEHRPRVKSGKPDALSRRSDHALTDADATEERVLNLFAAQLWQLESLSHETIRLAQQSDDHSRSLADRLRKDTAATGEKDYKLDPKGLIRWRGRLYVPDTGELRLRIMEENHNAPMAGHPGQTGTWELVRRHFYWPGQRVDINRFVGSCPTCARAKHARAKPAGLLKPIPPPERPWETVTLDFITSLPDSNGHTAILVMVDPLSKMAKFEPCGNDIDAPTLAECFVRRVVSQFGIPRALISDRGPQFTSHFWRSLTARLGTSLNLSTAFRPQVDGQTEIVNGWLRQYLRSFSCYQQDDWCDLLPLAEFAYNTSVHSTTGVSPFFAMYGFDPRGGDEATVPLLKPGDRRFTHHDALAKADKLRSLHEFLRRQIAIAQDIHKRYYDRRRTSPPQFKEGDLVYLDARNIRASRPSRKLSPKHLGPFPVDKVVRPDVYRLRLPPTMRIHPVFDVQLLKPVAANPYPGRVLREPEPEIVDGEEMWEVEAITDSRWFGRGRQREVRYHVRWRGFGPEYDTWEPAANVEGSGDLVSDFHARHPSKPRPRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW30</accession>
    <name>K1VW30_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear mRNA splicing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW30"/>
    <dbReference type="FunCoup" id="K1VW30">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VW30"/>
    <dbReference type="eggNOG" id="KOG0316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537685_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW30"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="507" mass="54906" checksum="DD0F5BBF62BA89FF" modified="2012-11-28" version="1">MTLDVQDASTSSGSFVVLHIGNTMSNNAASSFRSQLSGFRWANSVQDDSATTAPASQGNVFSRSWNSVSGYIPLRNEGASREEEAYFALSFALAFTLGSCLFMLGFAILHGPMAPHYLEGAFAVLDSVLRFARPDALLRHRRALDDWHPRRCHRPGRRAAHVPRRLPSGRCRDAPHGLTDAPARSRKRAARVVDACRVTHHVNNKTYRPIKGGTYVSFYLYAIADDSLSHEAGVNVIAYNHGSKYLLSGSSDRTIRLWNPATGKEVKVYRGQAHEILALDVASDNAKFASCGGDRAVFLWDVASGQTIRRLQGHFGKLHAVAFSNDASLLASGGFDAKIMLWDMRASTRDPLQTLKDATSSITSLSIPPDSVQIIAGSMDGHVRAYDIRMGQMTEDLVGLTAVVPSPSSPKDTLLVASQDGKLRLFDRSNGSTFSGHAVGQGRSRPAFNRGESAVLAGGEDGKLWAWNVLDAKPLAGFPQSPHRKAITSVLCNPNGKEMVTASLDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWP6</accession>
    <name>K1VWP6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWP6"/>
    <dbReference type="HOGENOM" id="CLU_1027399_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWP6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="29780" checksum="2B8B0941247DEB78" modified="2012-11-28" version="1">MWYTCTFPQNDTLNNACCPAGNVTDALQQGTSACSLGFGNATQFNECLLDTNVTHVRCYLQDWSNKPSNSATIRATSKPLGWATVTCIWLLFLNGVSGQVQPAKDPVCTKFIPDGQSSWNLTAETQHVITSIAIGCSAGPKGCMLSMDGKNLYFESVWSADGPEGPVPVTGDFDDLSLPTDRAFADKVYIPYMPDKLPVAAGHYGLTAAKTNAAIIPGVFRDCKNGTSEVRGNVTVPEARGLYYFTTWEKAAPPTGPDPQQNETMPLWQYQDGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX91</accession>
    <name>K1VX91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX91"/>
    <dbReference type="FunCoup" id="K1VX91">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX91"/>
    <dbReference type="eggNOG" id="ENOG502RAA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621302_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX91"/>
    <dbReference type="OMA" id="HKRDICY"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="434" mass="46423" checksum="26C9078414769BED" modified="2012-11-28" version="1">MQYGIEAEGESLPLLECRKFTAASGSSSGVMFNAGVPVWGLDWAAGSQHVAVSTCASDPAMGSRTTTPGSIQIWSAGGQCQVFLCTEAEVCAVKWMPVGVKDLNTLGVLAAAQLDGSVCVYAVPKPGPERVYIKAEPMVRIEVDDATAMCLDWVSGGRLTVGFSNALKEGDQTPLPDTYTPVALAAISAIHVARVPPVDSEGEPDYASDPYLVVFSSYDGSTGLLDLRDPAGTITFCRSRIPCSSVSWSPQNAAPLYIDSDYMVVMAQLRNASNPGTFILAPNRGPVLGLGCSDYHPMVAAAAADGGLTISSAATGFFRRKGVGLFYVRLYEVDYDEKIDTDPERTLKGTIRITDAFLPDHSTIEATNKRKDENRDDAAVKTAAWDREVGLHRAVWQNANGIKHAGWLASGGYAGIVRIEEVRGARLWPHEQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY79</accession>
    <name>K1VY79_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000089">
        <property type="protein sequence ID" value="EKD05561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY79"/>
    <dbReference type="STRING" id="1220162.K1VY79"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411714_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY79"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="4">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="4">
        <location>
            <begin position="155"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="667" mass="74205" checksum="90BC9B975C9FB1D2" modified="2012-11-28" version="1">MTQDTRIRIVRVSHMRYRHVDLAKARQFLEDFGMELAFSENNGKTLYFAGQGPDAYCYVAEQGEAEFLGGAFLVETKADLEKARSLPGATDIVPAGPADGLMITFRDPDNIPMTLVWGLEERKPKANAEEVPDINYPIQKIRKGEFRRFEKGPCPVFKLGHFGHDFDKTYEFFTARFNLKATDILHNPEGKNVSAFTHVDREEEWVDHHTFFFRQNADRQGVHHCSFEVNDPDVQAIGHEWLVSKGYTPSWGVGRHILGSQVFDYWYTPDDFMIEHYSDGDLVNCNTPTGRILAGPQSLAIWGPAVLVDASRVEHPGHSCALLSDKVLVSGHRLLPPEMWDPCLVADVPISGPTRPTRPTSHLPNRPPTHHHHVPPHHGGDSLMRPTTMTNDNKWTRLVRFVDEQGQERLGQPVDEKIDVGLAIAAGEKVEAFLISGDIYDGTVTPQKTTIVKLLSPVSRNDVSIIRCLGLNFMANRGIPNEPILFIKPRTALAGPGELPVAKAAQDDQLDFETELALVIGKDARDVSEADALQYVLGYTAANDVSVRKHQLANNQWCFGKGFDDSCPLGPVLVRNGVIDPDALAFKGELSGETMQESNTDDMIFSCARAVSFLSQGTTLERGSVILMGTPSGIGWARNPKRIIKDGEEMRIWFEGIGTLVNTFKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYU0</accession>
    <name>K1VYU0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYU0"/>
    <dbReference type="HOGENOM" id="CLU_510167_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYU0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="534" mass="62510" checksum="AFC4B745062FBDB2" modified="2012-11-28" version="1">MKLTDQRKRLTLPTELLHMIMFDLELDDLHKCRLICRSWNDAATAELRSFAVLNRGRVQRRWDPEAAKSGETYTPFWSHFSNAYWLHPFHGSRLRQPPLKEISIGLHHPRECQHLSTEEEVGISKLLEAAKNPYNYGLPSHLPVLKITLQSSPLFENYWRIEDDPDCTPFEQPTPIYGYKVANMHGEYIATPSKQPYTDGVNAVRPDDLTVQFTHCGFSDLVGAQVNTIGKLVLYNVPFMYGEVSDAVYDRFHHKVEEMVWVLTYPGRCKVSFECNDMGLCGEHATGIPDYKAKDLARIIPTDKDRRLKKVTIVFKPKDPSMKWDKGCRHRERRGAWWAPRLLGNLARELAKPEYAGIDFEFVNLDCLSLLHAWKPGRVIEPQIRRKYLPEWLRNMPGLESYGDEICLHAELDGIMRMAYHDAMWENPEVEIEEVNLRSTQLSFTTMKDWVESEGAYGILTAKEIFRYKEFWRLGPEKYYYQYPHSHDFFTDEHHHRPEERRRRWADDEESESDWESDEPVSDSESLIEDTSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ27</accession>
    <name>K1VZ27_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ27"/>
    <dbReference type="HOGENOM" id="CLU_1310883_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ27"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852578" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="79"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="210" mass="22639" checksum="3EC4EE795AC3B830" modified="2012-11-28" version="1">MLLKTLAALALLFSASAVPGSEWGGDHSPAHAVAPATMHANAKTPTARLCTEEFSPNGQYIDHGCGIAIQTHRKRYSGVLCVRTHADTKEGDDVFLAPCEALTTSGGRWDMLLGSTSIRNMQASEPGYCLAASSDRTRVVMAKCKDCEDQRWFTSLSDGYVGKIQWGGPESNLCLANPGSGRNVRELKLDWCNDFPGQVWEMSQLGEATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZY1</accession>
    <name>K1VZY1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000288">
        <property type="protein sequence ID" value="EKD02378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZY1"/>
    <dbReference type="FunCoup" id="K1VZY1">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZY1"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_4_1"/>
    <dbReference type="InParanoid" id="K1VZY1"/>
    <dbReference type="OMA" id="KMDHREI"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="375"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="221"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="473"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="732" mass="79320" checksum="5D04A9BB0A2AD481" modified="2012-11-28" version="1">MQPPATRLPRVGGSPTKASGIPKGIPKPVTRSALGAASTVAGEKRKVPESPKLPAKRSTSGPKLGKSTTGIKMSTRGAASFAPKRKASAPTLGKSTTSSITTRRGPVSEAAARRPASAAATRSTARPTTTTAAAATRPVRPATSLGGPSRTPSARTSAASRNGNVTPEDGRLDNLEKMLQMIHEEQTKMAALTATKEDLASVVLNAEDKERENRRALSNGSEEMEALRARHLRDMEEIERQLRTKERENRGLLSELSESSEELGRQRDIVRELRQQLADQSTQHMTLSAQLTASQAQNNALQIEVERATLAVSAMKAELEAGYQKAANAEELAALRIKEAQAECDRRVAEIEEELRTAETIRRKLHNQVQELKGNIRVFARVRPVLGREQDNPEGVAQITYGDERLAAETGQSQLEVRTKSESATGKEREQVLSFQFDKVFQPKDGQQAVFEEISMLAQSVLDGYNVCIFAYGQTGSGKSWTMEGGDTPETAGMIPRAIEMIFAVSAQLRDRGWKYTMEGTFLEVYNDVINDLLGSGQFDTKRHEIKIDKDNNMTVTDTVSLPLSNPQQVSTLLEKARSRRAVAATLMNERSSRSHSVFALKVRGYNPLTNESSQGILNLVDLAGSERLAQSGAGENKDRLKETININKSLSALADVIGALGQGQQGGHVPYRNSTLTRLLQTSLSGSSKTLMLCNLSPLAAHLGETVCSLRFATKVNTTPAGTAKRTLTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZZ0</accession>
    <name>K1VZZ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZZ0"/>
    <dbReference type="HOGENOM" id="CLU_973821_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZZ0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="32016" checksum="EE18A82ED59E2DD7" modified="2012-11-28" version="1">MVTYNTHPHIVELIALFSDPSTRALFRLVCRSLRDYVDIRSVLPGGVLFEWHGNGTPCNLETTEKLPVFSPTTFEWDGKDAQIDVISRAPRVTIGGGTTIPYIEELLSYLPEHSPVTITHDGTGPPLNMDMLAPLYLDVDAVVRCQCSRHQPGAVFRHAATHLTVHFTLPALLGNQADSACSLLRGLWSPTIQLLQLCFESPDWPFEALIPSIFPHPIVNSNLHIQFHFAWWPGYNVVETADNLRILLASYFGISLDRVTEVIAVRPFPTMPKVTCAHLPERPYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0S9</accession>
    <name>K1W0S9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0S9"/>
    <dbReference type="STRING" id="1220162.K1W0S9"/>
    <dbReference type="HOGENOM" id="CLU_041051_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0S9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="510" mass="55751" checksum="3AAA796D84823D1B" modified="2012-11-28" version="1">MPVRFTYANFPSLWDDIIASSGHEGQLVIRSIDRSLRSVIDARQVRHLILSPDQGNVVTVRGPHNGVAALRRLNPDSITEAQRALCANTGVIDVRGFFHPTFDLRPLAPLFPSLKVLRMISDAEQQITPYVPLPSETLVLFTNPSGLGGVYEHWYFRHPSESPATSEPGSDVENDYQYEVHGRRLAPRGVSRHKLPPQVKRIVVNMCGDHAPPTTMWPIVENPPSHVKDVVIVVPRYRILEGEGEMDAGCVESVLAIGILEMLRAPHPNFTLVGVDEVSEEYEDRLRELLRTDAAQVVHADVDYSIDDPLTSEMPIQIRRFAQEASEQMRVAREENPEEELETRPTEEDDEEAAEAGNVDTATTAAEEAAAVGAAVTQAAEEGEPEQQPAGEDVKAGENGTGGDVAATGPIARYGEVEVEGTGQPEDVEVGANVNRAGRGSAPSTPEGPVVPPSTSKQPLMSLQQKVDNLFARIEFLPKEQFIERVGEETAALELLEYLDPSEYDNGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0U2</accession>
    <name>K1W0U2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0U2"/>
    <dbReference type="eggNOG" id="ENOG502SA8U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025525_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0U2"/>
    <dbReference type="OrthoDB" id="3360632at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="508" mass="54441" checksum="7F73DB003E4C92FB" modified="2012-11-28" version="1">MSRPDLSVGHAGPSRARNFSNASGMSFVSAKSYHSATSNISDTDNLLRVGEGTSSPRPSLTNLSRPQSRASRTASVTSTGTMVFKKHAGKKDSDAEDGLSSEDEDDGEIEFGSRDGSDSLDYEEDEIPTSSTSDSFSINFSEMEHEDEMSEDIDADSDEPLTRADGQLVAPLILAHPLALFPALSAVPQSFLPAGVALFIPAFCILAALSACAHIVIVYLAWYLKVGSFEQVFAACAGERFGRFGQAVGRGFVVVATLGSSIGWLGTVASLLDPVVQEYLPNGLLRSRIFWTITGGIFTSDSDVAMWRKNRMADWQILPALIPSRSIRHLRALPVAFALLLPLVTFIVIGRTVEVKKAADEAGETIVTAAAAAAATLQHAAESAPEGVTAHIRRGLRGLSPKTAGSGLTTLTMFFTPHLQTLQIHGSLKRVKRQQFAVPILAAGVLILVLALPFALVPYYLLPPAPTAFDQLPRDDGWTNFARVLMCLLVLASISSWLVRGRDSVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0V9</accession>
    <name>K1W0V9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0V9"/>
    <dbReference type="STRING" id="1220162.K1W0V9"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009189_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0V9"/>
    <dbReference type="OMA" id="VKSNPPH"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="487"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1030" mass="109254" checksum="923B5593735C67E2" modified="2012-11-28" version="1">MSEQKGLFSTLSLGRTRSGGVNRVTSEPIAHPLLGTDDTKDKDLKDEPAAAADGSLPYKPRQRNSQWPNAAPSPTLQPSPATTTAAPAPSFAGEADTAAGKLQLQSLKAAAQRLGLKNGSMGMGMIEAIYDKGTRARDAGDWAELLKVLTSNKAVLLLPETAASSLPMTPQTLRDHIGFIAPPSGDGAVVITLSGLIGTLRGTVLSFESTAPGSPLLAALRDDEKRTAMLSTFRPTETSEALEFPGFTVSSEPSSLPFPPLGKQHQSERRDVPGRRMGFMSLFGSSGSGTPMQGRSLSPERATSPTPPSRVPSPRPSVMSLEDDSEGYSVTAYMVDKPVRYAEVHKHLVKAVRSTVKKGLEGLPDRVADKVVKLVMSSICPIAGSTVDQALLKSHHRGYSDADGAIPLDFSDPALCGERLQDFMEAIYDDLIKHYRPRRSVDTTRSGRSLDEEEDDTEASAGTERVEALVCSMLYNRIFSPLSSDDANHDEALASRIAGLNMAELTLDHLGLITRPPGDDGKLAAGLDGIVEQVGAELQKLNAPHCLKPKDKVDVLVAAHKLVVDGLAKLPPVKLRPEGEPYQPPGPGETAELSEIKADTKPEPASVDLNADEDASEDRGETSKDATPMSEETSEAQQETRPEDDTGTTASGADLILPLIIYSVVKSNPAHLASQLMYVRRYRSSILLRGDQSYAIVNLTAVVEFLEHVSLAELGLGSYSSRVLSVADLTPIGLGEMDPDVASASTRLKSRVFAVGELAVGSANKVLSGIADSGWSAMRGFMSPDHLAPPGAGAQPQSPTSPTQPGRPRGASTFSLASVTASVANIAAAASTAAARTRSQAGAEEDLVGGKELVDVPASSRPETPAQVYGSPVEEGENLLGASLGRSRSHSDARSTRSTRSDTRPGPASRTDSKSELKSSTGPKEKGQKGEKSRFASFGRLSSSENLAEAKDKGGFFSALTARQARRPSIMTSLDEGAPASEGEDFEPPVERWMVCDPGELRVGEVAALLRDYRRLAGVVAKLQRERERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1B3</accession>
    <name>K1W1B3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1B3"/>
    <dbReference type="FunCoup" id="K1W1B3">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W1B3"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_3_1_1"/>
    <dbReference type="InParanoid" id="K1W1B3"/>
    <dbReference type="OMA" id="ANRWECA"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD05587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="214" mass="23889" checksum="7A5FBC3667967DEB" modified="2012-11-28" version="1">MVQRGALIVFEGLDRSGKTTQVDRLIARLQKEGRKARLQKFPDRTTGIGKMIDAYLQSKAEMDDHAIHLLFSANRWECVSSILASLDAGESVVVDRYAFSGLAFSAAKGLDFGYCQAPDVGLPLPDLTLYLTLSPEVAAQRGAYGQERYENVELQKEVRRQFAAVFDDLRRKHGQERMVEVSAEGTLDEVEEAIWAEAQRALDPVEPIGTLWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2W0</accession>
    <name>K1W2W0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2W0"/>
    <dbReference type="STRING" id="1220162.K1W2W0"/>
    <dbReference type="eggNOG" id="ENOG502QXAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503616_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2W0"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53155" checksum="55325F99F0F68796" modified="2012-11-28" version="1">MQQLLDFAGRAYAYACPPPFGILNPIHRIALRAQPLTPDLLMWFNWLVLPLVPLVLISYLLVGGPKDKLARESRPIRAALAVAGWTMLTHSFLTRRFTTLLKDPVVDPWMALGRPRWVAAIDLAINLRHVYLGSVGLDTSAGPPNLALPELKPGERPQVEVHLRHWRRQPRPTTRLAAFARHLGHFLFIYCLEDALFTFVRAVGPDALAPPGGRAWLPQYDHIVPGLIAETRTILLPSTIGYVVPPFYVGVVLKAAAPMMIWGMLSGVYHLGAILCIGSGFWEPETWDTDMFDAPFRSTSLRDLVSPHVLNCTKTVIRVLHLPSNTFTFYGLIYLFSGLLHALGQISNDPPPQFSGVILFFLLAGLGNALEVMFKRVTGRFVGTLILNAWVDPGWAACSFFPDKGFGQLVVPYMLKHGLTLEPLHGAGSAIAEVVESKPVLAETFVKITAALAESVVESAVESVTTTTAAVIETVVAVAADAAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W317</accession>
    <name>K1W317_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W317"/>
    <dbReference type="STRING" id="1220162.K1W317"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_4_2_1"/>
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    <dbReference type="OMA" id="CADGHEA"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000024">
        <property type="entry name" value="Calcium/proton exchanger, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="154"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="484"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="633" mass="68662" checksum="D383A5D9DD7B15B8" modified="2012-11-28" version="1">MANPPVSIDEPEPDIRGFTHSSIDNSNDRTVIAHDLPAPLPQHHLDPTALLDEKTEHVTVYEHADLSQPNLQRHDFATHDANVKRVPEGGNNPNASVDTFEPHHGDDGEAPVKWEDPTYWQSFKNMMRGVPILWITPALVPVAWGLHFSHQNPVAVFVVSLLAIVPLAGGLGFATEELAIRCGDTWGGLLNATFGNAVELLVAILALVKGDIDIVQASMAGSILSNILLVLGMSYFAGGLRFHEQVYGVVGAQTMISLLGLSVFAILLPEAYHLAWPSTSTARSSAQSAEIPPEQMAIILSMSRGLSFILLACYVAYLLFTLWTHAYLFKQRDEIAVSALPTPSHQRVFPRPQWVPSLHTVISRDTDTKSQASSDDSHMHTLSVPTVELNGVAQPHRNSGSSSPGVQSPSILANNQQTPPELDIGRARAYSSASATRTSPSLRFRETTHPLSTATTIDTLDIEAQHHRVEAGLPENPRTKAIFAFGMLITFTGLAGLTAECLVDSIDGLTESTSVSREFVGLILLPVIGNAVEHITAVTVSLKDRLNLSMSIAVGSSIQVSLGILPLLVLIGWMIGQPMSLLFDTYETIVLVIAIILVNFAIADGRSQYLEGFVLMMAYVCIALVTWFYDPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W351</accession>
    <name>K1W351_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_091800_0_0_1"/>
    <dbReference type="InParanoid" id="K1W351"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30086" checksum="25BB621E45669684" modified="2012-11-28" version="1">MDPVEQPAPPLAQLFSGDFSFPVDEFLVLVETNTLPHKCYYAHTPHKTAYVANALTGRARLWYVRWAGEREHKAPVYNEKGQSFQSAWKTYKDKHYETFRRDLVAQFGIPEFITPPFALRHLTQNRLPVQQYVDRWTELANACLENLDSEYNRYWFIYGLRKEIRDHMLEVFPFFRTFAKIVDEAKAMEKHLQSKVVERVIERVIVQQVPAPPTPIASAPATPEVTTSPVAPLAPCAPSTPTTPAPPAAETLASPPPTDEIAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4K2</accession>
    <name>K1W4K2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4K2"/>
    <dbReference type="eggNOG" id="ENOG502RB68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1200539_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4K2"/>
    <dbReference type="OrthoDB" id="2593121at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="24966" checksum="019161105652E04B" modified="2012-11-28" version="1">MPADAPSPTPSTMPPPKRRANGGGSRNTKRRKADDSNDSGTEKGGARPAFGVGMVKGREDEWSEPADVKTKVDFLELPVDALYRYLELYTMPPAAPVIPPDSPRRDTPMAVDEPTEEKPSTTEGGEGEDGEKKEGEEGEGDDAAPPTTRSKTAPQRKATETHPPIKRGIMTLSDVHAARAVLADKANQHWMKGLGGGQNREGETIVNFLYKNKVGHGRLLRVYNPTPAPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5P3</accession>
    <name>K1W5P3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator HFI1/ADA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5P3"/>
    <dbReference type="STRING" id="1220162.K1W5P3"/>
    <dbReference type="eggNOG" id="ENOG502RX84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513878_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5P3"/>
    <dbReference type="OMA" id="IDTHRIK"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50367" checksum="D6EA7F2857DBD8E4" modified="2012-11-28" version="1">MSGHASHALATPGSVSAPMPSLTSTGPGVGAPSHRPSVPTPLGASVPLPSTPASPASNLPIPFQRIDTHRIKQQLYDALGEAGLPYWKALNGYLLGQVGRDELVALVRGWLKGKSLQLHNQLLTSLLHNASTPQIANQSASSLHMNKRRRGGIDAPDFDSDATYIEPMDRVANWAMGLGGRERERVRRAVDAEPEEVVEADEFDAMGKKRKWSAYQSGAAHPTLAQSGRNIPSSHQLALRLAQVAKTWNLEVAPDATKEVGEFMGVGLHQHLGDVLHSLVHLTGRDRPGEDTLRVPPGVHEPSPEAPDIPTPTLGTLQYLFTLAPSLHPQASPTLYKLESSLTIAEVEASKPREEREEEKEFDARTPRPAANLLPSATPQTQTVGLPGALPAALPNVPSPVKAASTLHAAAGQGKIETVSQTLQDTGLLKIDKAGRGEEGEGGDRKREKKHNLHWKYEDPALILKDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5U8</accession>
    <name>K1W5U8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5U8"/>
    <dbReference type="STRING" id="1220162.K1W5U8"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006770_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5U8"/>
    <dbReference type="OMA" id="DSLFLNW"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="173"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="769" mass="84303" checksum="4FA437A0BCA19B8F" modified="2012-11-28" version="1">MAINTYNEGLKIASVPSRAIAAESSISSLSPLTSPLPTLNKAFQLYISAAEAYSHLLSSALVAKADRPTVTKKWRLVLERAEKVKKRITELGGRVGAAEIDDEAEEAAVCRRASRFNNVVAELWRAPPPDREFVGDRYRDQTQPELADEQLAHDPEWAEVSPSLWDLKGADWQVSQGPGADCSVTAGIGSCLAHNERWGTTDALYPQAVSGQPKRSENAKHVVKLLLNGAWRNRPLHITARNNTSPLGPAWIPIAVKGYFKARGGYSIPGSNPAPDIYAFTGWIPEHLDLNSGFRREKEWKRLYDAWQKGQVILTLGSGVNVSEGMVPLHAYDIRETDGDRRLDIFDPGLARADHTLAEKLEGMDLNGERANGFTFSMSWDEVCSKFETLNLNWDPALLPNTISRHWSWPKPEALDVETDNLSQMCRQNVLDDVALHVFRDYTKGGQGRDKGRIITSAHQETVRYIVFGADSQNPYTNALHTLVRLPLREGDNIFNVLASRDRGHFQTGFTLTAFASQDTQLNLSRVSLALPFSETYKLTVGQPTNGAAGAKKSTLRLELQGAKDMAWNVKLLWGNGERVYDDTIVVASGAYSYGMAYCDISDVDAGTYTVLVSSYEQDDTGPFTLCVESSSPISLSPIPAEGAGMFSRSVSGKWDETTAGGRPSGNQYDRNPHVEVVFSTPATLQARLHLPTPGPIPINLTLFRRGVGNELGELVATSGPYVERMSGVSIGRTKLGPGVYVFVPSTYGTGELADWVLDVWADAAFSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W698</accession>
    <name>K1W698_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W698"/>
    <dbReference type="STRING" id="1220162.K1W698"/>
    <dbReference type="eggNOG" id="ENOG502S7RX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708209_0_0_1"/>
    <dbReference type="InParanoid" id="K1W698"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42811" checksum="66CB22A9BD15A39D" modified="2012-11-28" version="1">MGSLAVDPAGLGSPFHTPTTPRFYSTQTPASGSGSGSGPVPAAVAAADLHSPTASTRKTSLSKSLSAKELQFEPSSEISEGDAEEANEASMATFTDLPVEHIHTLADNPFLPVASRYLYNALTGASATYVARHMLYQYRHCSHKEILTFALRRPIVTIPVLEEMVRIWDERRDFKRRAARNRPTHVDGVPVTPRTTRPPLEVTDLPRRLFRHPPKPGQPSIDPMIPYLLNEYDPPINGHKGYALLKSVVNRNYDMVEFLLARGADPRYRGNKAVEAAIQIKDLRMVKLLVEPPALAETPKEGKSKKRRRLSDRIDIGQPLVALAMKQGTEEIVKYFVDEKGESLEPEGSEGSSAAQRGASSSQVTLVHSDQCYSPLLALCRASFLCASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6F8</accession>
    <name>K1W6F8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_08291</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6F8"/>
    <dbReference type="FunCoup" id="K1W6F8">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6F8"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="K1W6F8"/>
    <dbReference type="OMA" id="IRQRHWF"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000554">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKC97368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="182" mass="20650" checksum="C57A23858C42D5DD" modified="2012-11-28" version="1">MGLSVSRLLSGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRERITEAREELQRMLSEDELRDALLLVFANKQDLPNAMNAADITDKLGLHSLRQRQWYIQAACATSGDGLYEGLEWLSVNLKKRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6H8</accession>
    <name>K1W6H8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6H8"/>
    <dbReference type="STRING" id="1220162.K1W6H8"/>
    <dbReference type="eggNOG" id="KOG3670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1054441_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6H8"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854225" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28160" checksum="2E9DF581F4264503" modified="2012-11-28" version="1">MRKLSPLPALVAVLLLFPLLSFASFPWLAPLSALAAPLPGPKIPGKYVRFSDLDQCPDLAPHEPKSSRDVRLDNIGVVMALGDSITAGFLATPPTESDWLGDQRVLGGLVDLEEYRGVSYAIGGDRGSVTIPRILKRYTKPHGQSHGNHPPLACPHASCQHLPDDALNAAVSGAVSLNLPQQANDYLVPTYRNMSGADKQGWALLNVAVGANDILTAANSPFGPGTPEDYARGIREAVEALIVNIGMQLPTCFHRTRANAQSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6R2</accession>
    <name>K1W6R2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Siderophore-iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000220">
        <property type="protein sequence ID" value="EKD04603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6R2"/>
    <dbReference type="STRING" id="1220162.K1W6R2"/>
    <dbReference type="HOGENOM" id="CLU_345191_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6R2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF55">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="819" mass="91506" checksum="887C9FF5B626DB9C" modified="2012-11-28" version="1">MSAVNDLLQAGTLALRNLAALGVSMATRFQTDPASAARAGAPGSQSAGVAAPGTISAPAAQGDEEAQRSSGLPPQPKEPKVWEQRQRNIVWFFMFLNCTSFAFQHTLLWSGPVSPSVTLNEGEEKRPAGPIVADAFTVLSSLLLAFALDYVGRGLGMAVSLGTATIGLALFAASYDSPMRSAGQVFYGMGSTGVKAITDVLVVETVRQEIDMPLAYAFMALPRAIALFSVPTVRYGLREPERHVLIAFSCVVPALGAPLVCVLWYYRAHLVLHKPFRHLMMFVWARHSNRPAFLAGRFLLVATLLVVFLVLWLVQMDVSPWPAAIPPLVASLIVTAPFCEWARVQCQPVWFHFRFFLIPSLSRTRVRVRYRWQRRQWFKFRGLTSMLMPVRRARNFCRGLGREVASWSSGLKVNLQRWHLEFAVCASCLTWKMAHTCWSTNLHPYLQVAFSKSSVEARYLISMSTATEHLGMLLVGLYAVYRPHEIKPANLKSVPLYCFGLVVFILAISLGHIPSLFVASQVLLAVSRSAFEVTKELALLADCRYEWPDFLHRSPTLLAYLGLSEKVGGMIGATISDILWAKALHNPPNRYLNGQTILSAERVHPNLGQHLATPQGSPERGRIISNYDETQAIALAISGALMALAFLCLRGIQTSRHFTETLKRRDLSVVAYNSFVEEIVDLLDKHPGRQICEALKAPIHSQDLVEAYVLDMTEYKSLRSLKPEGRRMAVSRAAEATSPKRFTDPDIRTLEDFELRQSLYLALKDEEHCRRMLVALDDETVREQHVGALLSYRTIASSELCFQVREDYELWAKWHMRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1W740</accession>
    <name>K1W740_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W740"/>
    <dbReference type="FunCoup" id="K1W740">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W740"/>
    <dbReference type="eggNOG" id="KOG2817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020227_4_0_1"/>
    <dbReference type="InParanoid" id="K1W740"/>
    <dbReference type="OMA" id="LIRECKM"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="322"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="322"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="379" mass="41280" checksum="FABD5D6CDFC7D994" modified="2012-11-28" version="1">MSTADVSAALDALEALASTSATSSSGPLNALLEQHFAVARERILAGSPPKHVIAELQTNIAKAKKQVERGLKTWYAALGNTGKAVEKAFPPTLSDISSAYDDPPLFTEPEAAAALDRVVLDSLGRRGLWDAVLAFEAETDLAYDASKRDLSARLAEIVSDIEAGDLSSALAWCHANAAFLSSGPHPSPLPYHLHRAMLLAQPTPAAAVEYARTHMFEYLATQPVLELVTSRLFMGTKESPYEIENAPLAQMFRTDYCRCHGWAREDPLEVAVDLGSRGGALNAIEKARKVMGDRLGNVRTWPELPMEVHLPRNRRYHSVFVCPVSKEQASDTNPPTMLSCGHVINQESFNRLLKGNRKSAKCPYCPDETGQQGAQTLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W897</accession>
    <name>K1W897_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylthioribose-1-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W897"/>
    <dbReference type="FunCoup" id="K1W897">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W897"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_3_1"/>
    <dbReference type="InParanoid" id="K1W897"/>
    <dbReference type="OMA" id="QQKIVPR"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="241" mass="26155" checksum="2F5BEBE17E2FE302" modified="2012-11-28" version="1">MPKLPEMMTSLRVSDNGAVEIIDQLRLPHEVVCEPVKTPEEAFDAIKSMKIRGAPAIASLAALAIRQHLMTDAPKLESIEDVKAHLLPMLDYLQSSRPTAVNLGEAMDRIRRLLEASPASAPALLDSVKETCYAVHNEDLARNREMGCLGAEWLWSQRGEAAKAAGKKGLKVITVCNTGSLATSGYGTAIGVITALFEADELDTAYYAQTTPYHQGSRLTSLELTTLQLPACMVCDVRHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAI6</accession>
    <name>K1WAI6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAI6"/>
    <dbReference type="HOGENOM" id="CLU_799711_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAI6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="347" mass="37823" checksum="3A3D5E96A3A3BD00" modified="2012-11-28" version="1">MKKPIIAALGAIHTRLLGSRRLYCFRSPERFVDTCRPLEEEDTSTRGRGVEGPASLVPLVIVGGRVEALGESKGVCEESQRQVKVEAECSSQDVARVNTRKDHWWTSKSGRAANPAETQARQPRVGSRGLYYRVEKFEDVVELQHLRHNNTSHDTELGAGRHVDNTHDPAAALPPLPQEPLLPPGPACVVRPRSRVQNLPPRIKGQACLESASTTSRSRRVPPTRPRAPAEVQLRAERECALAPDQEHHALIPLRSEGVAGGAPIPAKDIPARPLSAPAAHEGEARRPEADEGEDGGTRQSAREGEEAEMGEGVGRNHIRPPYAEGELEDGMGGQGRRGEFARPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB46</accession>
    <name>K1WB46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB46"/>
    <dbReference type="FunCoup" id="K1WB46">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WB46"/>
    <dbReference type="eggNOG" id="KOG0296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
    <dbReference type="InParanoid" id="K1WB46"/>
    <dbReference type="OMA" id="GPDEVMW"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="372"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="460" mass="49240" checksum="399B2D5FF1C8678B" modified="2012-11-28" version="1">MTPEEERQLENNQEEEEEDVVLAAEDVAEVLEDDGLKPDEDMEEDLPADHEPMIKDEEEKGKPSNAWGGTFLHKPGSSIFALALHPMFPNPPLAVTGGQDDVAYVFCPLPPSQGGAWNRDTYQPVRLTGHTDSIACASFSNDGEYVATGGLDGRVRVWRRVKTRRGVTYDDADPEAWRFWEFITSLEAGGDVHWLQWHPKGPVLAAGCEDASVWLWNLPSGRTMTVLSSHTMACTAGIFPPPGKQLLTASLDSSLVLWNPAAGSHEFKSSIFYPPHAPELDPSVHGITSLAIAPSGLVACGSANGRIRLIAMPRGECVQTLDAHDKNESVEGLVFMDLLGGRDGGKGVVLVSASTDGQCFVFDATTGRGRAMMKHPAAVTAMTPHPAPSQHLITTACTDGSLRTWDVRNGILLAEHTGHPGAVLGVAVGKAPDGESPLGLPEAQLVISAGEEGASLIWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB82</accession>
    <name>K1WB82_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB82"/>
    <dbReference type="HOGENOM" id="CLU_1171333_0_0_1"/>
    <dbReference type="InParanoid" id="K1WB82"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="201" mass="21688" checksum="634C7A56DB85185D" modified="2012-11-28" version="1">MSTSAPEDDAADAAANAAAEAQAQAFAALARTSALAAAAPSIPHESADSTWMELWGQRVGDDMRFAAPVQCVCVQCRSPSAQHDCDYDHHPAEIVRTELSTESKCTSNPLTYDPDLPTLSTGGRYFAFRRGACVECTRVGRGAQCSASTVNSGQVWVFDTLTARWETHLVHGLWYSRKAGVRGRRARRPLSFCYAGSRGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD39</accession>
    <name>K1WD39_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_06104</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD39"/>
    <dbReference type="FunCoup" id="K1WD39">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WD39"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="K1WD39"/>
    <dbReference type="OMA" id="ASHCYSQ"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="445" mass="49163" checksum="44DB117E0E05BADA" modified="2012-11-28" version="1">MRRIPWSLFRPYGPVFGAPLMHWNYVQLEKLGEGTYATVYKGRSRTTSEIVALKEIHLDAEEGTPSTAIREISLMKELKHVNIVRLHDVIHTESKLVLIFEYCEQDLKRYMDTHGDRGALPLNTVKHFTYQLLNPQNLLINRRGELKIGDFGLARAFGVPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDIWSVGCIFAEMITGYPLFRGRDNNDQLVQIMKIVGTPSDATLQQIKMNSPEIQIKQPLSKHPKQPLHAIVPKAPRDAINLLEHLLQFEPNRRYDANEALAHPYFTAGPISPAVPPGVASGAASLALPPRVAARASQASAAVQAQQAQAALQAQQAAANQAAQAQAAAAQAAAQQAHAQAQMAQQTYNMMVQQHQSGQGQQAGPYYDPMQAQAQAHAAVQAQQAHAAALQQHAQYAQQQVHQAQQQGHYMNPDGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1WED6</accession>
    <name>K1WED6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WED6"/>
    <dbReference type="HOGENOM" id="CLU_1005393_0_0_1"/>
    <dbReference type="InParanoid" id="K1WED6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="277" mass="30580" checksum="577C1F39D81D4401" modified="2012-11-28" version="1">MPHVCAIGNKRITANPPVHQDSPIDLTDVPDSPKGNADDPIDIHDDDSDDMVKLETEGYQRMHPMHILVQHPQARSASPPRFNDGRLGIEEIRRRTSRLSRRRWPTGLPSMEEIYRLIVPTGAVVDAAVYYTGPHVPGDVWSEPGWTEDKCRLKFGVGYGQAARMPPLFNEHFLLDPTLRDLLVVAEAALIYDKPCESCIASGNMYCFADGRGGRRASTRCSRCVVLRRDCSNAKDSVSRAKRAAVQAAAEELAAVARNCGADPTIVARILEKVAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG06</accession>
    <name>K1WG06_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG06"/>
    <dbReference type="STRING" id="1220162.K1WG06"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="K1WG06"/>
    <dbReference type="OMA" id="YTSRGQF"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="554" mass="61793" checksum="E8566D37410967ED" modified="2012-11-28" version="1">MSYFNEKPPGISRHNIVTKLQKGKLLVAINAIASLSIFFFGYDQGMMGGVNNAEDYIKRMKFGYTEMKDGKPTPVVTDSLLQGGIVSVYYLGTLVGCLVGGWLADRAGRIRGIAFGAFVAIIGASLQCSAMNHNWMICARLINGWGTGILNAIVPVYSTETAEHKSRGMFIAVEFSLNIFGVVVAYWMEYGLSYIDGGRSPFRWRFPIAFQIIPLIVLLVAIWFFPESPRWLAKVGRNDEAQYVLGRLRGTDPEGQVEAKLEYEEIQAVIRDEAHIPTSYFAVFTGIGSGDLHLGRRSFLVILLQILQEWVGIAGVTIYAPTIFRLAGFDSDKAQWISGLNNIFYMFSTLICVFTLDVIGRRWTLYWGAVMQGIPMFLCGGLTRLGIDADARGDKAKAGSYGIGAASMIFIFTSVFGATWLTVPWLYPAEIFPLAVRAQGNAMGVFGWSIGNGWLSLLLPVCFEKIGEKTYYLFGIANFISIPIIYCLYPETNQRTLEEIDLLFADRTPWVWRAEKNFKRLQAERPDIAHALHAGKRVDVEQAEKTSDELHEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKQ2</accession>
    <name>K1WKQ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKQ2"/>
    <dbReference type="STRING" id="1220162.K1WKQ2"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="InParanoid" id="K1WKQ2"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="28761" checksum="5A873C5B1E023292" modified="2012-11-28" version="1">MLAMDALANPLDLTGRVALVTGGSGGIGRAIVSLFLQRGANVATTFVPGVEDAQKLHETFGSPASLTFHPLDLRSADSIRACLDSALEEHGRLDVLVNNAAVGSATVAAWTDSVAAQDAAMLAINADGTLKACQHFLRLPHEGPLPRKLINISSVGGGIAIFPGFRLSDGMSKAAVAFLTRQLGAECCHKAVDVFAVCPGATNTEMFRQSTLNPMSEQQRTDFLKALPKGRLIEPGEIAAIVNFLAGSASTVTNGAIIDASMGLGVRPGIMTEMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WL36</accession>
    <name>K1WL36_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WL36"/>
    <dbReference type="HOGENOM" id="CLU_1240906_0_0_1"/>
    <dbReference type="InParanoid" id="K1WL36"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="224" mass="24878" checksum="F260719EBB3BA0E1" modified="2012-11-28" version="1">MDRPSGSAPSQPSQTLEGPQSGVVKMVWPPGATFARVYETEEGSPGTLRSSIKPIPRPPSGGFVTFTEEELIRTKIRQQEPELACHVKDARYPFAFDVLLTKWGNSVGYPKRSSDGTGNLSPLPKQVYQLYFSASRLLARELEGPYHRTGFVPERFVFKYEHPHVSVEVVQSDEEVEARLASIARGPETVVGEGRLIDWNARLEEELSRPGDDSAQRSAGDQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMF5</accession>
    <name>K1WMF5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000293">
        <property type="protein sequence ID" value="EKD02304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMF5"/>
    <dbReference type="FunCoup" id="K1WMF5">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMF5"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_0_1"/>
    <dbReference type="InParanoid" id="K1WMF5"/>
    <dbReference type="OMA" id="ANCMHAL"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="762" mass="83683" checksum="97C4AE3273D41451" modified="2012-11-28" version="1">MAAPPRKGSYPTLNSEYRDRRADAIKRVIANHTIGKDCSGLFPDVVKNMKKLVYLYLMNYAKTQPELVILAVNTFVKNPLIRALAIRTMAMLRAEKILSYLATPLSRCLRDENPYVRKTAALCVAKVFDLKPEMCLEYGFIETLRDLVGDGNPMVVANAVTALADIHEAALAMPESEDENAPNKSLFIIDQSTLTKLLVALNECSEWGRIAILSTLSRYRTNDIDEAEHICERVMPQFQHANAAVVLGAIRVIMIHIKHVQREDLLKNLTRKMAPPLVTLISSAPEVQWVALRNINLLLQKRPELLQNEMRVFFCKYNDPPYVKVEKLDIMVRLATERNVDILLSELKEYASEVDVDFVRKAVRAVGQAAIKIEGAAERCVGVLMELIETRVSYVVQEAVIVIKDIFRKYPHSYEGIIPALCGSLEELDEPEARASLIWIVGEYAEKIENADELLGTFLESFKEESYAVQLQTLTAIVKLFLKKPDESQGIVQAVLQAATKDCDSADVRDRAYIYWRLLSSDPAAAKGVVLAARPPISLPQTTVSPAILEELVAEISSLASVYHKPAATFIGKGRLGAEDVKREDEDEGRERALQTVVNAQRTENLLDFDDEPAAEAGSSSADLASLGAPSASASGISQQTITNVAKSTNPLDELMDLFSSTSVAPSAPSPAPSPGFASPGFASPAVASPAPPAPQQQQQQQQQAQQAQQQQQNADPFASLNFGSASPAKAASPVQPQQQQQQQQPSNNKPQSAEEDLLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMW3</accession>
    <name>K1WMW3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMW3"/>
    <dbReference type="FunCoup" id="K1WMW3">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WMW3"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_1_0_1"/>
    <dbReference type="InParanoid" id="K1WMW3"/>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="135" mass="14520" checksum="636363F684F1306D" modified="2012-11-28" version="1">MSDAGSNASNAPEQVEQVEVADNSGPMSVEQALEEVVKTALSAKALDKREAHLCVLVETVTEAEYSKLIEALCAEHNIQLIKVSDAKVLGQWAGLSKIDREGKPRKVVGCSCVVITNYGAETAGLQVLLDYFKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNT4</accession>
    <name>K1WNT4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Swi5-dependent recombination DNA repair protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNT4"/>
    <dbReference type="STRING" id="1220162.K1WNT4"/>
    <dbReference type="eggNOG" id="ENOG502RB88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647563_0_0_1"/>
    <dbReference type="InParanoid" id="K1WNT4"/>
    <dbReference type="OMA" id="MEPENEM"/>
    <dbReference type="OrthoDB" id="2576607at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46800" checksum="D6A62C94249E8B38" modified="2012-11-28" version="1">MSSWSLVLWHPPPSYAPPAEEEPLYTLNPHVTALLRDENRLPRLLSIPAAFPPLCTFEEATSEEVMEPSSTGITLETQLMDVDSPEPPIESTVIMPVDEDEPPPPDATPPTVAEEDKQPSEEDEPSTGVRHQGMHKRPAAEPVDTAKVLKRPFKSPARVVLRGAKRKPESPLPSPVSSPALPTPQIEWPNKLPAKLSSLSPPLPHSPRSTSSRSSSRRLNAKFKPPGPSSASSDSEPSRSSRRRRGPDAELIANLEQRVRVLKQASACGEDERVVALIQQWRAAGREVTERLFRMIPEPEPELPQRSKGRSSGWGWGWDETFTEPVSRACVEFIRDECAVKNGEIVDPEGVPLQDDVALDDLLPRGGGRVVEAKRPRILTDNDVLAPPEVQPWNRGTMLSKLGIDPALLGFNVEEDDWDDIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQ58</accession>
    <name>K1WQ58_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQ58"/>
    <dbReference type="FunCoup" id="K1WQ58">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQ58"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039675_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQ58"/>
    <dbReference type="OMA" id="SFAQVRW"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="332" mass="38260" checksum="157303EF32468FCE" modified="2012-11-28" version="1">MEGLLAEINKKKSKDFAPAKPEEKYLSRGEKERLREEAERAERERREAEREAAKKRKADEAQEERATKMRKESRSQAAEAVADDSEDRYAISPEECTRRLRLFGEPIRYFGETDSERKKRLKALELESESRGGLKQVQNDFKKAKEDLDRREQERRARGEASGAGTPQPSSKSEEKAKQYTSELLDLELIKTDFNKLHPIIFWNFKALLKEWEEYLEARPEDAKKSAAGKLASTTQLQSAQNLKPLFKKLRNRDLDNDVVVSLAEIVHFVQKREYRNANDSYLKLSIGNAAWPLGVTSVGIHERSSDSKITHNVAHVLNDEVSRKYIQAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WS28</accession>
    <name>K1WS28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WS28"/>
    <dbReference type="FunCoup" id="K1WS28">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WS28"/>
    <dbReference type="eggNOG" id="KOG1120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_0_2_1"/>
    <dbReference type="InParanoid" id="K1WS28"/>
    <dbReference type="OMA" id="MRAAFTI"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="92"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="199" mass="21454" checksum="611B35D9BF74FEB9" modified="2012-11-28" version="1">MSFSVLRHSRLLAQAPRTVAAVRLLSTPPARAEVRTTTPTPTVPPPNFNNPPASASAGSSVQPSKNIDSKPSSSSSSSSRPRRTIKSKKAALTMTPEAIERLRALQANPTEPKLLRIGVKTRGCAGMAYHLDYVDPPGGKFDEVVEQDGVRVLIDSKALFSIIGSRMDWRDTKLSAGFVFDNPNIVDTCGCGESFNIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTG5</accession>
    <name>K1WTG5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTG5"/>
    <dbReference type="eggNOG" id="ENOG502RR7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313128_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTG5"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="496"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="953" mass="103108" checksum="92586E26F242B40D" modified="2012-11-28" version="1">MKLLIWIESDTWDTWGKAGKDSSGSVGTVVSVTSAQGFIGGVKVGVPDESGGGLEYLLRPQARSQGQAEVGISALAQSPGQLDHLVLPLPPVPPVPRTAALPRLSARHQYTRHKPQSTTQVLTTDPTRPPPTYLPPYLLSIFLIQQPAVLAPRLPAINSDSNNGPPSPRPEQEEAASHTPQLRGVPSHQIEILSDTHTAERHTPDSADNNQVTDHGRAARLAHICPNQVSKITQPKSVTIAELTARVKYLEESLRRNGLAHELTASEAPSVTAPNASLSPPNMPSSLPGSSRSAVEMAAMLGHMALGHIPTKRHAGMGTTAFYLSSPEQSEDEGSEDERRGSNLWKPPWGRSTGVSLTGKGHLPGVLLDRCRIMLPSRRAAKDMFNTFFEVTSWRIQPMTPAFFDTVLASVYDSSEGAHPHDLAVLFATMAMTMLFDEAASGAAQGFQAKDYHETAYSCLQAGNFYTETSLSSLICLHLLGSFLINSDDKRLPDGIFPITGLGVRLAIIAGYHRDKETAHAGTRPEEADWRRRIWHELLALERVHCLTALLPGSIAHDHYDTPYPSDAHKEGYFVWKWNLGVHMQRVHDFWTRVETPDLNNIDAGLRRLLHSLPAHLRCSSFPIEAFPLVRPGAPAVVVSPPPASAASPGSSDYTTTLSAERLLHQQYRMATHICMVFFYLHRPIFMRAMATGDPSCELSVRTIIEVCERMLQLVRGILNQDGSMARWFSFAADLFSVLLCQAVLVVKTTEAHLVPQRLGVLEEGLAILEWTVKLRPNSKNRALTQRMRRVVAKAREALAASGLGASPNHVEVERVEFQPGLGVLPLHSLGFPPTAFALPHQSFQPELLSNAGNSNSARVNPLGNGNGAAPGGPGGPGGAVTGGVAAQMGNGVHGAKQHTPSDSSPQDMAEDAAQTANDENFEAWLAMLFPPGTGEMPVVDPALLDAWAAQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVU8</accession>
    <name>K1WVU8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVU8"/>
    <dbReference type="HOGENOM" id="CLU_1817154_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVU8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="142" mass="15089" checksum="E0373DB239A97C34" modified="2012-11-28" version="1">MARLLGGQLQDGGQGDARPARHRAAEYKAAPESARDQSHRYHPPCCGRLQRAPSSPASASGARATTARPKRPSTTLTSAGRGADMDGPILQSLQPEQRLWVLRSHPHAGAWTVLDVWGARRQGRLDPWAAALSARNGGDGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WX60</accession>
    <name>K1WX60_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WX60"/>
    <dbReference type="STRING" id="1220162.K1WX60"/>
    <dbReference type="eggNOG" id="ENOG502QS80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013511_0_0_1"/>
    <dbReference type="InParanoid" id="K1WX60"/>
    <dbReference type="OMA" id="QTELAIF"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016864">
        <property type="entry name" value="UCP028035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028035">
        <property type="entry name" value="UCP028035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="10"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="975" mass="110847" checksum="49253FCA6223298A" modified="2012-11-28" version="1">MDRPFDYEGYKRDTAHVVRWVLTTFNKILRANPLHEGIDVPEIAPDEEAPTFNRTGKAQCRELLSKVRYISRYVSCAPSEVLRKLRSAIRLREEAYAHFQKLSKTNPRYANGNKGHKDFINVLQQMFEQLGGSGWLIRDKAGEPDLTEQEATVRLINYFEKLHVEHGEDVKEPSADEEEPSTRHRAQQQRKKKGKAGKKRPKTKKVPPPEQEEDPVEMLENLPLERFEILPDEDSAVTDHLIAVHGLIQECVDVRRYIQDVWHDVAYDELNSAVAGALTNTAIAAVTRRGQKLQEEFGGTASYDAVNEIVAGGDIAKIQGQFGMPYTSGGERKWAEIDVTEQFMVPAYRDLVEFVTDYRLNRNGKPTKRMQKELARWDPDLDLVKASTEERLSWRRLYTLNWLYELVRVYTYPVAQGISAGKEYKWEDVDWSPSGPWASHRRLFGLDNFASFLTTLATQKPGAPIADKIRHHHVLQLQLFVDSFAVTRGWAIHVIRGHVLETPTAGFECQRDIDMFLDRDEQRGQQGFLPAMEQSMEGLKMALGSLRSEDNAFLEVLEAVDDQLTEWLGAADPLIDIPGLAPPRFPEFDGLWRYSPLLCGVGLEEALEMVALLGRLLCDALSELIPLMHVYNMLTQRGYLEPIDLFEIVLEMYPDAFFEGGEVPESDFMAALFRRLGAQSIHDVPRKLGRRDYGLPEDPLEGRTVWELLQSHKYEFFTTEPLLIAARRAGWDPAKVSPETFDFPSLMGWDVLRRTPRVRGATGERFADTPFVKRVRARSARASGLNEADLVARVRRYNTPYRARDAGHIGLRAITDGSAAPPPPRSESPTEVPPSQLPAWSLREYLDLLRVDFNNDVCGKPYPRSGINYFSVASLVLQATERIVSALTHMHHNICIAATRSGRCEPDPITVLALLLEADEAALEAVAMQFEDVDFGYWEFNYWDVVEAPERRSQKKTKKKWEDGLPAEPETCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0D6</accession>
    <name>K1V0D6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Response to osmotic stress-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V0D6"/>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253659_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0D6"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="786"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="224"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="395"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1212"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1272"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1299"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1376"/>
            <end position="1395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1411" mass="152038" checksum="226A92F34A57A01D" modified="2012-11-28" version="1">MDSRLHSEVPGTKITPSSPTRPGPPDAYAHSAQSTPARGGRDASISPSASMSSMNSGLASAPWAGGSGGVASGALAGGAVGGAVGGISGLPGDRRTVGHGVPPPQGQPVDSTRHSYQGHPYQQQDQKVLRDGSIQPGTRTSSIGAVESHSRNNSAGQQDYGSAFGGRAYGSNSPASASTETFGIPGGLERNEGVPAHASGTAASAPVTTHGSGGVVSAGSNPFGVDLVIPYDISGEKGDEAEIERGYRRLTDALQSAGLRIASRPAKGKGKGQEEVWVFVGASDGKVKELIEREHVVDESHGLRTAESNPNFPSDRIRLLYDLLTASKLQHGLGITPGEGDWARVKSIAALHDDERDKAWVERWAVADWKTGLLQGLSREDEAALSRDQPPAVRLYFNYLVFYTLSLVPIAAISLLFWLFAPADSYPPAYAFALALYSTTFVACWRIRERKLAVRWGLRGVEQVIGLMRPQYVLSHHLTTTTESHRRADVRRDGKIVLSVPIIMGCGLLLGCVLMAIFFLEAFVGHLWDGFGKEVLPLLPTALFSLVVPQVVALFTALARRLVRWENHPTYTSASRSLTAKTFALNATVAFLGLYLSAYLYLPFGPYLMSYIHNILSPDQGEVVIKSDGVNTSIRTRNHPGAHRDKINASRLKSQVFAYTVTNQVINTFLEVGLPFILRWVNDLRSGNKSVKGMFNGKEEKKREATESTEDKFLDKVAAELELPEYNIFTDYAEMVTQFGYVVIWAIVWPLAPVFALINNYFELRSDALKICQHVRRPVGPRVESIGTWLDTLSIISWLGAWTSATLIYLFRPSADRVVSTTAKYLASFDALPSYSTIWGTLVRVALVALAASHAWFVLNSLVTSICEKLFWRGSKEQRIVDGAGTLNADRTQQVLAKLDNSAGPDPLAGHGFWNGAAEGEAEIVKVFKKDLMPDGVLVMHERYESQINSTPLPTLTTLLYDLSQLSAVPCIGFSPLDQRLANTPDQRSHGRVHPREQRRREQAQEAKPRRATQPDVGQLRGADDTDEGPPPNEHRELQGQQRLDADAAERSQPPGTDHAPAEPTPEQAQQYLVLAVQLFLAHSGCPEQSGAAGAQFAREGGSAVVPWYSARGRTGPRTRDAEWVSAADIGGARRVAELRSALTAEEKSLATLRRQFSSAVAAEHETPPRRLKPRTPSISEPLAPLRALSPSSNSTLSSRPLTAPRTSGEGRSPDKAKQDGKEGPLATLKESMGSSNPAQDTIGVGALWSAMAQDAEETIQEGKRFWGQLMKSVTASPQGNTGKSQRPESHIGLTGIKSMLPSLPSLLPDAAPPSRPKDVRLKRASLTPLSPSPNPKVSLSGSSGSEIGLSRTASRNSAISSASSQNLSAQGMSRSEGRGEGKEGEEKGDKRRSEPPTPSSLAAVLGNVMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1V309</accession>
    <name>K1V309_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V309"/>
    <dbReference type="HOGENOM" id="CLU_485008_0_0_1"/>
    <dbReference type="InParanoid" id="K1V309"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="562" mass="61264" checksum="4BBB59C72AFA4C48" modified="2012-11-28" version="1">MMAHHPPHSHRQSKHTLLPLAYTMHRRTSPLLTTHTPRRGAPRHNSPVTSNVSQSPSFLRFPSSTTKLIRLLRWLSRGPNPWDRSRTLASSALRPHRRTSEEDSAAVMESGCTFPECCYQARGPGSGPNLRPHHGCRCPFAADRGPVRMLCGAHGQLALAAKRFCKLSEAEYLYYLSKVLGMVVITKPCTGPNCSNLLPPFYPASLLFVCGGEYLWKSHLTDSQDISLCHTCEGAHKRSLRKHEAEAKEDLGQAFIIEAPLIHVSERALPCADKTALDCPGTALASTSRATSKAKLSVRGARGSIWKLSIISPDCTPPYGDDCYPGQPPPPQLGYAAGHASRRVLGGGHLIVHRRSGGTLGLSYHASFKGKNVPDGTFAKMATAFRNGNSIRFGLHHTGIAPSTSTKDRPFAAWSVRAAGGARQARSSPLVLYPFVARTLVDHPCLWATTTARARSADRFAALDGVFSGRRTTAEMFLKALYQANKDVADAYAAKVVGQAESSMSPLKATDACGSHAVKVKRCQEEPQRGPDLRRLLPMTMARTFLKAQYEMEVQSIESAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V478</accession>
    <name>K1V478_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V478"/>
    <dbReference type="STRING" id="1220162.K1V478"/>
    <dbReference type="eggNOG" id="ENOG502RYFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685474_0_0_1"/>
    <dbReference type="InParanoid" id="K1V478"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="402" mass="44494" checksum="51992B5F226B5989" modified="2012-11-28" version="1">MPTELLSFPPAYSVVGLYRLLTDPSIREPVYAKVKHASVRGAIVSGAYAILGWGIMDWVVKKFVLRGKTGTVTLGHGSLSINIDLLFYTHLLILLPQLGSIMRFFIIKNLRIARSRAFNLTVQSRGKPAEFWNQGYVEEWQDPPKPTTSERKLFGRLRGPTHHQEKWVKWLLWWPSKIVIKNSFGFVASWLEGLPIIGLLFSVSNRIGAAMWAHDLEKRQHLFGHHVLKPLPPNRTGMFGSGTALDITPEVVRQEKEIHAKWSHRPAYAPVTVDSEEIDDQPPSYEMSEGDSLRRSAGAPASSDVRGVSGSVDVGLTQAAQRMPPPLPPRKGNVEPHMPDKIPRPGRPGAQQATAPIPDVSDREVNAIGLRGSILHDEVLEPCAEAAELANSMTCIDSDGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4C9</accession>
    <name>K1V4C9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4C9"/>
    <dbReference type="HOGENOM" id="CLU_523971_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4C9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="426"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="57345" checksum="07BBD38B60D249E7" modified="2012-11-28" version="1">MSNPTQRLPMEVSSLASKFEVEPEIASLSTTLAVSRPATSALHFPSTSPGGTHHPERKAWYKAEHRKQIWERATPTKVAKPICVVVRYGNVVWHAKVGEETYIYYLKSGQMGCMSPHPPLSMTVPIASDTEDVSSLSRSMAAVGIGGSLPRATRLRTESEKAALLEKDKPSSDSRAPSVISTTASLNSEKTINDVKPWIRGVRSARDNGWILDEKLARGRSGPRSTRGAFDIKIRYGNINDTWEVYTTSPVWRLKKMKDNLTLGHYGMEDGDIIDVLPDFNLRPSRSQITTAFLIIMPSFTLLTPCPLSPPSIAFKPYFTMTVATSSDSTHSVSCLSRGLALLGLSPTSKRAPLSEKNLNLHNGSDASSGSGSETSSTESWFTVEKPEKTAKIDGVEKHPASDSASQLVVETYEEDLPEYTEKSAIAVAVRYKNRELFFIVKPTTRIKTIKNFGSKGELRPNELQLNYNGRKLRDRMTVAECGMEDGDEILCMIDFGTLESLGAADVRLYPHGWVIRAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9Z2</accession>
    <name>K1V9Z2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_08155</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9Z2"/>
    <dbReference type="STRING" id="1220162.K1V9Z2"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066250_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9Z2"/>
    <dbReference type="OMA" id="YGLKMNA"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="102"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="31457" checksum="833A14BB5CA08F5E" modified="2012-11-28" version="1">MAPSHPLRRVSTGSLNSLARSTDRPQSNAGLDVLAPALQDLADEVAALSTNTQRISALHDALGQFNEGFAAYLYALKMNAFCVEWPQAPNDSTLARLQQLGGQLQPDPEPTPSPPPQPASQVQQREDEDENAAADMTYATAYSPEPKRSAPSRSRVPPPRAGGAGVPVKKKPAGPGLAERKAAAAAKKKRDIKISKLIDSSLPLEYRGANRDNRITMEGVIERLMVDYENDGDGLASSRRLCQAGSTAPAREQVSDRARREEARDEAERERDQEASTGRDLDAQSEEGRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBV1</accession>
    <name>K1VBV1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBV1"/>
    <dbReference type="STRING" id="1220162.K1VBV1"/>
    <dbReference type="HOGENOM" id="CLU_516988_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBV1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="527" mass="57579" checksum="577384F4991E8713" modified="2012-11-28" version="1">MTASPLEATTNSTAAALEPQQEPLWEFGALTLDTSSSSTRRRSTHRRSQSTATLATSREYRSDYHSSASRGLERPIELRRDSMTTSASALSLPTLAEDNDDNPPERPKLQRGRTWVVEPPTTYTHSRRGSNATIAGQFVSQTTSGSLRHRATISFGTPASPGLSRRGSFASLHGEPTPLPVPASVSVSDVAAMATMSQEPTTPSRRNSTANPSDTLRARLRTLSQLEGKAPEPGTPPRLLSPATPRSNRGTPGHSSSARGTPGSSTPTSSNHHHHLAPPSPTPTSRRLMRSHNHRHSMPDATLLFQDLPTTSCLRQPAQLRMGGAKETLWEPNRTLERRSSARESSRGLERRSSQRDSSRDSRTSNRYSLEMPPPPLPLSRRPSAAPSVSGEEPPEILLPYRSAPRDAPGDLFTVRPPRPPRRGSTLSMVETPTPTSSEQSSPGSLVSDSGSLSPTSIESLSIGPAMMRERERERAREEAQLKLTAISAYSTRRNSRGPAWKARRARVTQSMHLDLDEERFLDFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBX2</accession>
    <name>K1VBX2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBX2"/>
    <dbReference type="FunCoup" id="K1VBX2">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBX2"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_269284_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBX2"/>
    <dbReference type="OMA" id="ENDASCW"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="4">
        <location>
            <begin position="712"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="848"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="5">
        <location>
            <begin position="1090"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1215" mass="137482" checksum="AABAA74B7C445905" modified="2012-11-28" version="1">MASFFGFASAPVDVEIRLNGEDDRKQVEVKGEHDKKELCPVYYDGESVEGKVVVRVKDGKKFQHDGIRIELVGSIELFYDRGNRYDFVSLSQELAGPGEMRQAQTFDFTFKNVEKQYESYSGINVKLRYHLKDVIVGKVYFLLVRIKIKHMELSIIRRETTGAAPNLYNESETITKFEIMDGAPVRGETIPIRLFLGGFELTPTFRDVNKKFSTRYFLSLVLIDEENRRYFKQQEITLYRIPFPLTVLGMLFELQAIDKRLNQKVLLMQEAASAAQKAQDSLASFSLDLGSLIGRDASKSPRYPEKYIKTLDGILQKVAMGQDSKFRRAVAFFWSSSWADKTFQRQLKESRKLEDIILAFVSAATKSLRKEHDLADGGWKAELNPQILMFLDLLHDSLSSVGSGGTELRARLSTYRSRLQSDNTGVTSSAPTVGALPEDNRPMARSAFELDVVLKVLPVESSKLAEAVDALRSSSSVEAALEDLKRLDAGNESPYDRDEFADERTWSDFQARERSALLQLSRELQNLELTKDRSGDRSEVNGITAALDSTGLGPHRFFYIPTDPRQTYRQLLRVCLDYDLQVLRTLPEDQDVSLGILSAEHTDFLTECANRWRLPLSFRSWVFLEAIQEHYEHGEVPPDCVFEAVGGVGRASQELPVSEWPVSDQSGLQTVLLRRNTFFLNDVEVALTSPKGYLSPEFRQAVSQWQLLDATDEDHVVLQRIQRAICDRLRQQAYTNYIDEASEMYAREGGKNRQFALALASWIESGAKKLDKWFPEPISPANSHSSSVTDLFDSFHSAISFLLGLRWDDPEQMATFATRLAKSCVKLNNIDAMRHQLDRLYLDMRVDEFASLDVNQPVSASTGQSSLFTIKIVLGEGLQVDGGAKAPDSFVVLSDEHGNRYAKTRTIYDDFDPRWDETFDIAIRQPSWFMVTVRHRSLSGKHDLVGRAYLRLDPSQYVDFISKDVLLPLNTKGHVLLRVSMEGERDDIQFHFGRAFRWLKRTESDMMTPVLRHTLSRNNIKSVLKPNTGIDYNDALRISNDAIGRISAAYRNAVSAAQGDYSIPLPPSEVQSAKSQSATLKRGPTEAEIETAIHPLFDYLDTNNHTLASTLSSDAMQMVMAKLWKQILTTIEALIVPPLSDKPSQMRALSHSELDIALRWLKFLRDFFFAGGDDSGVPLNILQNAKFNEIMSVSMYYDWSTDELMEVGAYSVDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCU2</accession>
    <name>K1VCU2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear envelope-endoplasmic reticulum network protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCU2"/>
    <dbReference type="STRING" id="1220162.K1VCU2"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353737_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCU2"/>
    <dbReference type="OMA" id="EYDHARM"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="763" mass="82069" checksum="13573EA923737F64" modified="2012-11-28" version="1">MDAIRLPIQPTGAQLSEHVAALDLLAARLDALASRQAWPALVPFNSKASFPGSIINTNSVKIATGPDSWAEMPPAHAAEYDHARMTEGQAPNAAQPPLPPHRSLKTKDVRFSPVLRRPEDNPAQPVAQQVAEQQPKEGQFALRGPNGEEQEVPASLRSLVDLVGEHLADKLHLPGDETVNEEGLPIHEIRETPDGQLIGSEPMGDGDGEETIPEKEDDYWTPEAAARREALKRRVFGSMSDSDTEDEDDSMDVEPAAAESAPAQEAANGLVPPIGRPSTPPNDPSPINEPLYAQPAHRSPGKQPKGILKAPSRKKSVTFDSSVPLPPDSPPAKPGQERISIAQKPVPILNVPTPGKRAFGGLKSGFLQSANAAAERDKAAAAPTQSNLAPSPSATKPNFASRGVVEHAPVPPQPQEPPPASKIQEIGSDDDEDDSMDVDEDKPKKSLFAQRRAGAKPDFPSIGSQKPMPTMRNSIVERAPLPPSVGELPKSSTSAAPADRTPLVVVDNDSDTDEYGDLGEFDDDEEDEYALDEALLQREAALALHRSLQRQRPIDEDEIDPEAEGDGNVYMAVPRVSTIQGGEGDEPLRIINPTADDLGQFLRVGREEDGGLVFEPPTVHEDSESDGEEEGQDAEDRRQRRKRRRDVMDQLRAGVYNPDEPVRDPTKVMRDYEGSLPPSVQSQPEPQPMQDVVERQPAPSVASGGVVERPPAVGGVTERAPPAPKPKPSAIGGVVERNTDTAAPEPPQPPKKVSRFKAARQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD41</accession>
    <name>K1VD41_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000308">
        <property type="protein sequence ID" value="EKD01900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD41"/>
    <dbReference type="HOGENOM" id="CLU_2456357_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD41"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="89" mass="10129" checksum="A1E1752C0434D024" modified="2012-11-28" version="1">MFFTHDYLYFSARSNRYLREQESEQASASLGTMPLCRPVSSYEYLPQLAQKEHRASLLEPTTLSSAVVAPLPTLHVRAHTVARSQPHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD91</accession>
    <name>K1VD91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD91"/>
    <dbReference type="HOGENOM" id="CLU_1541201_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD91"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="174" mass="19860" checksum="26C0F473EF9910A0" modified="2012-11-28" version="1">MTWVGAGKYYEVEPDGLKMKTVAGGNGKYFFTPSQLREAYPAIAEEAIAYMATGPRGDFCQVVIDQVHDNIVRLRGRYNDNGGHGCKLLHGKTLGWDRKDWGRQYLHLNGPLTVVSIPAPRDERGKLLSNEELQERHRMAMAKGEPLRWKKVWVSEREPQYRIDDGKDDRTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEF7</accession>
    <name>K1VEF7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEF7"/>
    <dbReference type="FunCoup" id="K1VEF7">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEF7"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_4_3_1"/>
    <dbReference type="InParanoid" id="K1VEF7"/>
    <dbReference type="OMA" id="EIMDLCC"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="386"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="433" mass="44914" checksum="AA75C85831AB3120" modified="2012-11-28" version="1">MEDSHSVHLYLPPGGGTNEPSEDIPEQPAGSTVSNEGGEDKGVAMAAVFDGHGGSTVAKFSGTTLHTRLASLDSYKSGDYETALKQAFLKTDEDLRADPTFFNDPSGCTAVLSLITPDGRIIVGEAKAMSNDHKPTNKEETARITAAGGFVEFGNLALSRAIGDFEFKQNYTLQPEQQIVTADPEIITHKADGEEEFLVLACDGIWDCLSSQQVIDFVRRAVANGDDMGKICEDLMVKCLATDSETGGIGCDNMTVVIIALLNGRTTEEWQAWIKERVDNKVGRDTPESIPDVFGQSQSPVGGGFGGGGGGFRIAGAGGLANIVNILGASGIRFQTADDDEDGELHIVDPSSAEGLILSEDEHGAKLDLVDDDGDSHMDSGEDSDATAAATEPAASASASATSGSATGTAQAPTTETTPSSSASASKASGAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEN6</accession>
    <name>K1VEN6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEN6"/>
    <dbReference type="eggNOG" id="ENOG502RBAE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361760_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEN6"/>
    <dbReference type="OMA" id="RCESTPA"/>
    <dbReference type="OrthoDB" id="3268641at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="773" mass="83999" checksum="9173AF0F24E3C9FB" modified="2012-11-28" version="1">MGETLRTPPALGPRMPKNGTLMVDYPELNVAEPLLDTYSPFPTFGSGDPFGLNAFLLHPADPTFDYLLTRPIAGELLPADQHAKVPPGLFNQRLTPSSLQPPGLTAKDTRRRSPLALEVKPEDDEEDQSADSGSMSRLRPMSVGNSLRAMIGRKSAAPEAESPIEEDAAYVRSESVSSALSSSSSTDGSDGLRTPRDSTHNSPDETSAAAAKLAAALAEDDERRPKSVSWRNWLGSKNKRGSFLPFRSDDASPSESGTTLQESPRASAIDLATEAPVPEGISRSAIQLRRVSLNKLGSLRMPSPHPLALVLMRQRANLPDEVAFSIPSSKRVFPMSVNAHQGVGSDLMPAQGGLRLALAVRNVITKLDAGDRPPELSQVKSRQPPRQNAIRPRGVRDFVDRKPFEERMLVYHPDGSCSQISMARSGFAIEDLDFSDHILALMRVQETPSSSSSSLSQRSSLAPTRSQSTNNLSIRSQPQTRMSTVPATGRPVSSFRKPTKPATWDDSSDEEGDVPPSRPVALRSQTAPARAVNKNAVNRVSRVMDAQTALEVVTKARERRQDNDSGNVERRQVGADITREQRRKSMMPTSVSTSALVQKDSRPAAQQRASSMAITALKARDQTSRNPRARASSATLATKAREDAHAEAAAKLTGSKTGRSEHRTRSPAPSLPATSRSQGRHSLNPSLRARQSTMAMGMYPMPMAPVPTVAMYGSPMMGQPMMFTPMMPVMTGPMQPNHTAMYHQPQYGSMVPNMPNYRPRPPATGRRRERPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFB3</accession>
    <name>K1VFB3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VFB3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFB3"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002027_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFB3"/>
    <dbReference type="OMA" id="CVFVKHK"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1393" mass="149608" checksum="62A40F9BE6AA7BF3" modified="2012-11-28" version="1">MTGSDKEPGSPSDHHHHHHVSISALRNKFETLAHDTRDYVSKSRPVSPRPPATPAADHSAEATAPHAVDPPLADEPPVGQDDSVPIVNPNLVVKVPQPVKSKPKPPPKPASKPPPVKETTVVTAVGTPVNIPTAGSTAKVPPPRPPKPSASSLSASPKAPVQSPSPVLSPTPIYERYSRPRSPLCQPSPPPRVVASPEPGPPLVAEESPAPAPGPIPAGPAGDVDEAPQSFAAIRERFAKGTAAAAPSSSGSLTAKKPGDTPSTRSSSARTSPAPSVHVQAPTLLPPLKKEKPGSPHPPSSFVAPPLSTTEAPAVPDSRPKVASSGASTAEKSDRAPPPPPPISRSASPSRLMRSASPADLQRSASPANLAPGGHTLTASPVQSPVLMRSESPVEIDEPVQLDQAPHSHRPPPPPPPKSAAQRDEPVILQPTPTPHSHRPPPPPPKKSTTSVASAGSADSQTGNVPKPPLPVRRPTGNAGEGAIPVAPPPLPQRSNTLGPSPDLPTDTAKASSRPPLPGNKPAAPTPKSPSPPESVPQRPRSRTVAGARPAGAPPLPVRQNTMSTGHSPSPASRSRASSVADRGALPPPPQRSDTASTGLHRSSTVSSRGSGYAPPPRRDTISTPQRSGTIMVPADSDDEDDASATATPGLTSMAARLLEEHPDGSQANRRPPQFSPDIEIKAAHSITAFTVYGRFVVCAHHHVKVYDSHLPEGPILDFDPKHMGLDSKVKEPRVTSLCFRPSTNDAHEGRYLWCGNRDGHIWELDIRTGEITATHPGVHSAAVTHIMRSGRNMVTLDEFGKLNVWEVPTTDGPEDEGGVRMVRNLRITEKPTFVKMIRGQLWAATAPAVRSTTNSATARGPTVRVWDITYPGTAPPPLMALTTEWTGSATSAAVMPLDPSITYIGHEGGFVSLWTISDGQLQCVRVLKVSSTDILSLEGVGERLWAGNRRGEIHAWKLDEMPWVTTNIWNAHGDQPVHTLVVDPYSIEATRRFMAWSCSRDTLHAWDGLLAIDWIDCQMVARQEQYCEFREVRILVCSWNIDSAKPTDLVGGPNSNFLPELLSSVESPDIIVFGFQEVIPLTDKKLTAKTLLFGKGGSDRVSGVYQAWAEKLSLEVRKNLGPYTKVHSEQLVGLFAVMFVKTELRDSLRDVSVSTVKRGIGGMYGNKGALVARMVLDDTSICFINVHLAAGQRHKAARNADVAAIMDDKAVFPPADKLPYVHGGDGSGILDHEFVILNGDLNYRIDQRRDVVISALSRGDLASLLEHDQLRKEMKSNHAFRLRYFAEAPIDFLPTYKYDPGTDEYDSSEKKRIPAWCDRILFTSSPRISAINYRRYEPTVSDHKPVSAALAVQVKRVIPDRMRKVQREIDQDWQLREAELLVKMADAYKALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFE2</accession>
    <name>K1VFE2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome-c oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFE2"/>
    <dbReference type="STRING" id="1220162.K1VFE2"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140536_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFE2"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="116" mass="12652" checksum="9CE349A514B30389" modified="2012-11-28" version="1">MSPNPIARSTPKAPPTTVLAQAGPFTNDLFFSTHHSTPRNHTANMAVAPITGMLKKRLLFDIGAGLGLGFAGGYAFWYGVHVPMMKKRDNYYAKLDAKKYGKDAVPTDILQESVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFN1</accession>
    <name>K1VFN1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFN1"/>
    <dbReference type="STRING" id="1220162.K1VFN1"/>
    <dbReference type="eggNOG" id="ENOG502QSUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026443_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFN1"/>
    <dbReference type="OMA" id="MQTAIPC"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="400" mass="42089" checksum="E2E4745B24D343EE" modified="2012-11-28" version="1">MIPRSLLLLRGVRSQPSTRLSPTFPSFTPMSKRHYGQSRPVPATFYRGGTSKALLFNDADLPPSREERDALFLSAMGSPDPNGRQLDGMGGGYSSVSKVVVVGKSEQEGADVDYTFCQAVGPFALETGLVPPHPTERGNLVRIFNTNTSKLVHALFPADGTRPLLSGGYTIDGVSGSHARISLEFLNPHGSRTGRFLPTGHVVDTLDLGEWGVVQASLVDCGNPCAFVLASDVGMSGTETPAEIKGDVLAKLNALRNAASVAMGLTGTMAEADKKRSVPKVVVLSPPSEHAVLSGAVLGREDTDVVCRCISAGDPHRALPITAALCTAAAAQVPGTLVAKVARRGDDGIVIGHASGTIAVDARVEQTPQGWEVPSASVFRTARKLFEGNVFVDEVEELDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGE3</accession>
    <name>K1VGE3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGE3"/>
    <dbReference type="HOGENOM" id="CLU_1338367_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGE3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22904" checksum="B91A9D12503AF338" modified="2012-11-28" version="1">MATIDHLGFPHIVDLIFAFAPPESLAALGTACRDWRRRACAELHHLRDFSTSRKQTSSGISTQTYSFQTLSDTWAQTSDPLFLKFSRILDLAAGVLGGKVDPGIMVHTIRLPRVRPPLIIAPKIPPLAGYGCSRLVFDNHFALSIARRIDKLVVNYRGSFPYLAAPGADCRLPGFEVGELVFIFHAWDEPGWQRKTAEEYRERPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGN6</accession>
    <name>K1VGN6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IgA peptidase M64-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGN6"/>
    <dbReference type="eggNOG" id="ENOG502RITG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030040_1_0_1"/>
    <dbReference type="InParanoid" id="K1VGN6"/>
    <dbReference type="OMA" id="WENGNIT"/>
    <dbReference type="OrthoDB" id="2961863at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851852" description="IgA peptidase M64-domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48537" checksum="1047A0DC5E6DEA94" modified="2012-11-28" version="1">MASSPGLTAASMLLLFGTLALANQVVFSHGVHGSDHLGPSVPHRWFSEFDARANGDDGKAPEGMELIPLAVQGENGDRVNLAIFADGYEKDKFLADIKTLTDDIVGESGAMAHVADLVNVYGVWVESEKSGLGHDGPLPGSPFGLYREGATLRAVMPGYPKRARAACQQWSKDKDACDQAVILGNDELYGGLGGEFTITTSSKANGVVVARHELGHSLIEVGEEYDGGYVYSGDNSDLVENVGKIKWADHLSEPNPVIQDAHVAIQNYAWHNLNTSWSGTPSSANNKSCSDAYDNSMLRLSLSSIAQPDHINVTLNGENIDLAPGFLPEMKDSLDRRWVEIFLTEPLPVGNSSLQISLTQKGREAKEGKGGKMVTSVEIIEYGRSFVKQEGFVGAFPTVWENGNITLRPTNEECIMRKVNYPSFCSVCKDSLRKHLLGRIEKKKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH33</accession>
    <name>K1VH33_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH33"/>
    <dbReference type="STRING" id="1220162.K1VH33"/>
    <dbReference type="eggNOG" id="ENOG502QUN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1644913_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH33"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="161" mass="17433" checksum="1037363F150D4842" modified="2012-11-28" version="1">MGFISTAYAAQLSPTVSLATRFGVNIYSYESDFSVGGEWWIGRRFGGGRGPAVEPTPEELETIAKRAKLGGSLRDDPGPDSEPELIDIAEKAMRQVGAARLKADKERDGVLKASLRGDWSLALLYESRIRNCLVSVGLVSDVFSGTSRAIRGVGLEVQYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHB5</accession>
    <name>K1VHB5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHB5"/>
    <dbReference type="STRING" id="1220162.K1VHB5"/>
    <dbReference type="eggNOG" id="ENOG502SGA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2086475_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHB5"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="117" mass="13413" checksum="52DB76FCDD3AA8CE" modified="2012-11-28" version="1">MARYRPPPPPPNPLRLGGVLTYSVRIDGHLGTAMLEWWEALIVGIVVLPITALFWYSCFKYFPSQFHYMSRRFAYYVFGDENVDMIAAVRGYIAELLNLLWFYIRGAPAKAAVGHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHG2</accession>
    <name>K1VHG2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254800_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHG2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1395" mass="148095" checksum="934612E5C06DC29A" modified="2012-11-28" version="1">MLAALYAAPLVCLGLSAGLSAWRRPELLVLTGHALLSLVAGWVHSGQYGGRTGNVLLALASTPAIAVLLGVGVMRPRKSMMALTATHTSCANSASLTPDTSSNSLRPAPIYRFLASLRPTSLRWSLLATVPVITLSLLLALFAPVASVMALNAVLVALHTSVYAYSAPLPGFWPFSPVSSPVLPQEEDKISSEKSLRERQVEDWVGTFEDTRQQVVDEWSLSFTTAATASRRRSASTQSSPMRVASRLYSPVKARLLRTQDSGIDDTFGHTTTGPSTSGVYDTAKSTDNTYTTAQSKASKTSKASKTSEHSVRFARPLSPTPKAARLGFDESDMSVPAPLRLPPLAKVAPSQGSSRKPSTPPRSQHDPVHSTENGTPTSWLSSPGQSSILHPDWSFSSSGSDPAAFLSSTVPRASIDTRRSIDVRRSINTSRLSVDGYRKSMSVDLPREPPYAFLSQDPTQKRKRGSTQTAASVSFHDYVSVHSAHSTSRQKLSDAPGTVRRLSCPASIAESFNMSVGGSILGDYSASPSQPLPRSFESLRSFRTRTQSKSSHEPDAEPETQERWEVVPPFVSEFVPAELFKERNSEDVPSFFVDIVEDKEVQTWSLGWPGVLGSLLLLGLSSPALLAEGVATRALLLASSFVPALVVTTSSILSPRPVEVDIEAEQKRIKYHPRDRSLRPTHGKLLRARPELSFAPPSPLKSRPRTMSAAARLRTLRGGIVSAMAPAMGHCASDSVGSTGTHDTQASTRSQAEEADGSHGWLDAHIGVATVATRSRSPSVLKLDWTGIASAPTTPARKTMTHVKSPRKSPAKGTPRKGKDSDDDEEEDDDDDVLAAATAVAHSPSRVQRRRTSAFATSGCDFSLPSSGYAPSLRGSITGAAAAAQRALPKRAPLNRVVTCPISKASAPPPRLPKSSGASGASGASNSTAASALSAASGVTSDAPHTASSSDTFGTKAASTATDSRVDFSTYDFSKPRQISSSEGEGIGRAVLGFNIPPPTTPMPPAPSVPAAPLALAPRNISAEKIDLYSTPARRAKSSETSSILRNAELARLLLAEGTPAPARHKRSFSGGSVRSHPYSVSRSARSSRSTKSSKGSKGHKSSASWASIKASLKSSVPSPLTPKFAPKRPSTPSTIARLESSFEERFEQDPPAPRSHPHPRPFSCDYATPWDHAPLRSRAPLARPVPDVGSSYEVSSRENTRLHTTSKRSKSEAAFVKHLDKSEKGLRPLVLAERHNVNVNEPVKRSPRFGGTPNVSGVSLSDETEDEISYFDVSSSLKPGIKAFVSRLSGTPDKNPGASTERDSGTASQRASASQRMSQRTSIFGLGNIWNSSSVSAGNSQPGIEAATLVGPTNDTLSSTPSLPCPLLNDPATLKHVSSSTLAEPRAPAPPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHN8</accession>
    <name>K1VHN8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHN8"/>
    <dbReference type="FunCoup" id="K1VHN8">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHN8"/>
    <dbReference type="eggNOG" id="KOG1897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002893_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHN8"/>
    <dbReference type="OMA" id="IVDFCLF"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="104"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="446"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="756"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1119" mass="120284" checksum="8E2B1C4611C02365" modified="2012-11-28" version="1">MLYIASTLTPTPVTHSVAVTGFTGEGQSLVVAKPDRVEVWDVTATGLVFRGELTIWGTIAGLAVTNISVEPIQGGALDYLVSQARATDTSSAKARVLHGRHHRQQRRSSLTLDSIREHNLLDLTFVPCEDSGNPVLTFLWMSEENKILLQPRALSLQTHSFTDLAARTDVVNPLDLPMSDVDNPNFLETDFSCPAGRSVLSLGMGPNGCRSFLVVGDEFAVMYCINPVPASPKTIAKGPVKRSPRSEAGGTGKRRKSSQSGRSVNTDPEPLWSVQPVWRVRQGFGTVLAVLLGDEYGRLTAVGWEFEDMEKVQVGMIDMGVVSAPSSLTYLDNGYLFSASACGDSLLVYLVLPSPNSTRQPSGKGKEKAHDISDAGAYEIVTAEPQHGRVDVRERWMNIAPAKDFAIVKEDDGRVSHVVVASGSASSNSFRVVRSGVGFENLMTIEEIPGIERMWTIPAADGPSLLVSFAYSTTILQLEPEVSVFKAADQVTAVPTFAAGLVDKSLLLQVTPEGIRLWSDLAAGTLAGNVDAPEDNRIVTANVRGNIAVAAFRDGTVTLFRASSQGLQEVVKGFLAIADWCGEIELVAVEGADQGTVLKSIREAAYATSLQFQESNNEPTRMLAGLSDGTFVSYSVKLNGAECSDNRHASSLGLRPLRLITLDISPNAEEHVVAAGISDRLSLVFESRDHYEFSSSGKKGIVFERLTSLKKLQVQTLDLGNRSATRVAALPGYNLVVAGTVTRSMDHQTGDVLQSSSVELRNATTLELLSEFQLPEREAVASVNAVTLHGRKYILVGTAIFENEDALEDATLEDVTSFIATNRGRLLLFQINESAGPSLDLVTSMTFNGPVYDTVVIHGFLAVATSTKVSILRLTTQPPSLEEAASFAFAFETHHLAVVEIDKEKRLVVGDAMRSIIVLSVDPESGDIVGDQRDMNAHLVRCLSAVHDVEPGVMIADNYANLLTFRLGKGITPAASIGLSEDVTRLQPGTLAPVSAEGDILRADLLCTTVNGRLGVIGELGKGSIRTLDDLQRNMNKLYKGPGGLEWKESGNMLVPRETVGFIDGDFVQRFSSLDSSLQDKILSGTSAPEAVSKVVDGELENASKADVERILEIVGALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHZ6</accession>
    <name>K1VHZ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHZ6"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003918_2_0_1"/>
    <dbReference type="InParanoid" id="K1VHZ6"/>
    <dbReference type="OMA" id="RIANFEM"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1202"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="498"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="1172"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="1305"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="741"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="772"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1546" mass="170410" checksum="B6696A01209D35CC" modified="2012-11-28" version="1">MTTPSSPTPPPAGDSDPPVGSPMTSSTQSPGPSTPAILVSSIDNPERDRSRSRSRTRFAVGSSPPRSRSASRHSRSRSSLRYSVDEPFTPTAQPVQLSSSDLPSPDQAPRKVPSPVIGTSSSPPPPPTRQLSTQQGAAPEPHIPSGDAMLAVSDTGVPIIKPKPVRPLRKGSTYEPDPADSDREHKDDDIIELKPIKAKAGRGRRMRSPSTATTTSQNQGDTPLADALIKPKGQVDDFHDPTFDEKSEGSDVTKIGAIKSRLNGTTKTDAGSNNSDDSNAKGSDGILGGAAWGEKGARRRAAPANGAERHIAFDVESAEGEDDEGKEEDAAGKKKKKGSKWSQSPLKEPIDKLLHIIWIFLGKPEFGWIKPRLNWNDMEPVFRVGLSVRDQGRAFTDGTDMVGVHSHPHQALGAGYWHGGLPGSHRCVHGAPMAADCAVPGDRPQPVFLRIRWLGMGKLLSVSCNAKFKVALGTFVANAVRVEMDPAKVQAGLAAAGGSMTKAIFNGTFIQARPCIVCAVWLSVGTGIALRTAPSPATFPLVLTCIMIDVMGWTVFKPIAIQAGIGFVCSIFVFPQSVTHQFRRKFVGVLKPLAQGMAELEEHFTQAASLVDGGDGPNHHSPREPFPPNDDRTSFDSDRSTDEEHKIHAWGDWSASIRTTLLGSLAGMQPLQAQERYLDVDISYTRLSGHDLKDLFYLLTSMQIRASGLSFFFNQIVNKIRRTHLDSGAFNAHSTLGLSRANSAQPYSRPLSRATSHVGSRPPSRGISRPASARDIRRNSSSKEIREVHSAGAKELRDARSHSYRDLKDSRNPSARDVREHALVDSTPATPRSGHVTPHRASTDDMRDHAKTLAHKLHLFRQNDKNLHSSRQSTSDLHSLKGSTTALQALRDLTGKGSHISLLDRLRKSQQPVGVYESQRYMDMELADDSDLQPLVRQLELLAAGALPLVKSLKKCLNGAVAWSQAKDKKRWTEDKSLAKSLATMKIILTEFKEHRVRVIDPYRDMFDPLHPTWQRLTPIQHKGLYYCFVAQYHLIEFSEAVLAFIEKALEKDAQRPKKKLWLPRLLALFKQFRESVKSEVDHAAGDNGEDDDQELEDEEREMYEHELDHHELGAAGRRDPDYSPYTNVFLVILSKITKIPDLIFSKSGMYAVKAGMLGCLTSLPAFFSSSAGFYYANRGIWCTIMAQLTLAVYAGDTFSAWFGRLQATFWGCCIGTAVWYIGSGSGKGNPYGLATICFFVFMVLNGFYRNYNPGPMLTRVMTNASLMLVVGYTTNATWGWDVGWRRFVCVVIGITCAWVFTYFPPTYSARHAIRYSYAGTINKAGRILCTILSAANDPHEQIDPAWNPAIRKELVKTRTKIGSLGIRHNNAKKEFSIRGEWPEERYRGLMNTLIETMSLLSQLNHLLPQMDWKWRKAFLMRTRMNDPLFLGDVLAIISMSSTALRVGSPLPQITPGPLVAKYHLNKYKGLDVPLVDPAKAAFDDDDIPSVVTIEVLESEEYMRYALGVSTAYALMSRLDAIIVACKSLLGENYHIANMKLDGMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIP9</accession>
    <name>K1VIP9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIP9"/>
    <dbReference type="HOGENOM" id="CLU_1116420_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIP9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="27727" checksum="69458ED32D860165" modified="2012-11-28" version="1">MQWEQSTALQVVLAQTFQGRKLMFHVVAIILAAFQVLADSCPRSFLLHPNGNKNYCLTIDEVHSAGSPVYVRRCADPPAFGQVWYFMPFPRNAGYFLRNVIAGTNNLCLNAEICEFPTPPVDLIEPAHQQQRQALTPDRLESPPYNGRHLAITECYNDGANDWKQNGHHQIELGAFVDGRSTFRRLPLLTHQSPVWISATGGSMAVQSRSGIAMKEATIRTSAGRLRVMSLKTKVRDVARPDRDVVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJE1</accession>
    <name>K1VJE1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetamidase (Predicted)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJE1"/>
    <dbReference type="STRING" id="1220162.K1VJE1"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="K1VJE1"/>
    <dbReference type="OMA" id="NTITEVW"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="74"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="526" mass="57562" checksum="F4C8D9C13B6273A1" modified="2012-11-28" version="1">MPDGVALAKKAIAARDATIPKEYALPESLFPLPKDRRDLLQRSGLLDKKELEIVNQGVIPLAKAIADKKYTSVEVTKAFIKAAAIAQQATNCVLELFPEEALQRAKELDDYQAKNGKTVGPLHGVPISIKDHIRQKGHAAPCGFLYAVDQIADKDSHLFAILREAGAVPYCRTINCQAVMHLECRSAWGATLNPHNVDLVPGGSTGGEGALLAMRGSPLGIGSDIGGSVRSPAAACGIFSFKPSIGRVPNTGAETLSAAPGYEGIISTLGPMGHSVEDLELIMKIVADAKPWNYDPSLQVKPWRKVEQKGKLRVGVLRDDGVVRPVGSVQRALDYAVDKLKKNPNFEVVEYKPYKSERSWELIVSRDRLWKADAQTHLYFPDGGKLVYDSLAKADEPADPMTDWIVGQGRALDRDEIINLVAERDAYRMEVAHHWQGAGIDCLLSPVGPTPAPQPFTAKYWNVDKQDEKDKQDGYKPRNDKEKEIYSTYDPEVAQGAPLCLQVIGYVGHEEETIDAMKKIVDAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKM3</accession>
    <name>K1VKM3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKM3"/>
    <dbReference type="HOGENOM" id="CLU_763307_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKM3"/>
    <dbReference type="OMA" id="STGVHGY"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853869" evidence="2">
        <location>
            <begin position="17"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="363" mass="33417" checksum="E00930EA2163CCD5" modified="2012-11-28" version="1">MKAAVLLATLPLLAAATVSTPEQKELPVERIAADEQYEQPLEKRQSGCLAQCTGSVGCDALWGCVWEKCQGSDWDDANGQDGQNGQDGQGGQGGQGGDGGQGGGDQNQGQQGGDQNQGQQGGDQNQGQQGQDTSGGNGVGIVGGGTTGGDNNGQQGQQGGQSATPSGSSAGASQTGAGAAGQSGSQSGSQSGSQTGAGAAGQSGSQTGSQSGSQTPGAAGAAGQTGSQSGSQSGSQTGAAGAGQTGSQSGSQSAQSGSQSGSQTGGAGAAGQTGSQSGSQSGSQTGAGAAATSSSQSGAAAGQSSTSSSQGRVNQLTSQAGSAGSAATSSAGSAAGGDGNSASALKISGVVAAIAGAAGFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL94</accession>
    <name>K1VL94_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL94"/>
    <dbReference type="STRING" id="1220162.K1VL94"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037639_1_1_1"/>
    <dbReference type="InParanoid" id="K1VL94"/>
    <dbReference type="OMA" id="IKAHFAS"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="333" mass="35708" checksum="289A27C810F90AB4" modified="2012-11-28" version="1">MSAPLSKKQQKAQSFRAKQKAKRAAVPDLPEQDDDVEVSESADLASTSTSAKAKPSKAKAEPAVDEDEAYAPLPEKKKDDSADGEKAGGKKKRKRTDGDGTEDAEIEGYGKVQKHRRVTEPKPKKEVAQRFILFLGNIGFKTTKDEVAAHFKESVGRIPAVRLLTDKATGKSRGIAFLELANGNELQSALKQHHSILNGKRINVELTAGGGGKSEGRREKLKQRNERVSTQREKREKEAKEKEAKAKAAKGDQAGQAAEQPPIVGEMSNQGAKIGAGGGGGDAGWGAPIGEGYKMRGGRRVKVKPSGGPGGDRERRPQRPKWQPTGANAQPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLL3</accession>
    <name>K1VLL3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SWI/SNF-related matrix associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLL3"/>
    <dbReference type="FunCoup" id="K1VLL3">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLL3"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032229_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLL3"/>
    <dbReference type="OMA" id="WWEREEF"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="504" mass="57223" checksum="6F562C8A0FF78EC9" modified="2012-11-28" version="1">MPYQYATPTRPPTHAPRPGYPPQAHPQHAAHAQPQRPQVYQLPLQYPDGPLGFFLPPPGQRTLDPTLQTQPATQGLFTTYPSRLRTGVTSLMQPENAEGGPKEREAWSEQFDIDEAARSSGANTPRTDSPAPRLSRTTTTTLSGRRAGRVNYAEKESSDEEEEESEEEIEEAASDPDDDTYGERKRKKDDLVQQQKVIKRKKREEQAKTWTWIGDRVPAERVTSSLAPRSRMEVQSEEKLQAEAGRAEALVPISIDYDIPDPNGEGKGLKIKDRFLWNASEPFVKPLEFATIFCHDVGIHENNAATIAELIMSQVEEQQNAVAIDLATRDVTPDDVVFSDDESPADDEYPEPDCRIIVNLDLQIFQHVLRDRIEWDLSSPLPPAEFARHYCAELGLTGEAVPIVAHAIHEELIKHKRDALEMDLFAQTHPGEQAKWERTGGQPKTNSRTGAKGLVGVWRDWWERDEFSPLLFEISHDDMVKREQERSREARRIMRTLHTSKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM26</accession>
    <name>K1VM26_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000141">
        <property type="protein sequence ID" value="EKD05170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM26"/>
    <dbReference type="STRING" id="1220162.K1VM26"/>
    <dbReference type="HOGENOM" id="CLU_584203_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM26"/>
    <dbReference type="OMA" id="SFERTEC"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851955" evidence="2">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="468" mass="44449" checksum="9BB82F9FB2C04B0C" modified="2012-11-28" version="1">MRYELAVSLFMALAALGAPAAPVQERDDAASPTAFAELVTPGDHHQNLCDGKDNCKTAINDDKGCRIVWGHGSFPTGITKPEHKDKADLCGKLPNCRTVSVGEGSWKIEWGGAWKPTPTGPITRPTTPPNLCDGKQNCKTVQNDEHGWKITWGYSNSWGWSGKWGHGSGGGNNNGGGGGGGGGGGGGGGNGGGNGGGHGGGHGNGQGSNAGSATATATSGSGSATSGSGSNTSGSGSNTSGSGSNTSGSGSNTSGSGSNTSGSGSNTSGSGSNTSGSGSNTSGSGSNTSGSGSNTSGSGSNTSGSVSATGGGSGSSASATSGSGSATSGGTSGVGTPVTSPYPSGSGAPGTSTSGTSVARVARDTRGHQGGQGQQGGLGHLGTVGETGKNGGKNGQNGKNGQNGQNGQNGQNGQNGQNGQNGQNGQNGQNGQNGQNGQNGQNGLNGHNGNNGLNGNNGHNGNNGLNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM39</accession>
    <name>K1VM39_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SIMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM39"/>
    <dbReference type="HOGENOM" id="CLU_980673_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM39"/>
    <dbReference type="OrthoDB" id="3335918at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.170">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052022">
        <property type="entry name" value="26kDa_periplasmic_antigen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387:SF2">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852288" description="SIMPL domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31124" checksum="8B91E4E98D351390" modified="2012-11-28" version="1">MDNHFWISVLLSLVVGALSTGIARTALRCRTSPPRIELSGEHEVRRVPELCDVYVRIRDESKQPGEAMQRVSATASSFAEQVRTLAPAKLGDAEPRLALDASEATDVPEEFPPSSPEKPVTGWSMQQIRSWSFERTPPRHPDPNDNTEYGKFYVAEASAKITFHDFAELSAFVMELSPLISIDRLAWRLSPGTERGLYARVRQAALRDAIQKAENYAQVLAIPGARVHVTDISDSSSGGGAAPRAMFAAAAPMGRSAKQANTITIEPEPIDVVANIFVKFEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM52</accession>
    <name>K1VM52_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM52"/>
    <dbReference type="HOGENOM" id="CLU_2160188_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM52"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="12718" checksum="609DC5065ABA5032" modified="2012-11-28" version="1">MGSLRLDALEKQASQRLGLELAEAIEFRRLLLEQSFLLGRDDEVLPDSEPVGRLNVVKIFLYKRDPSLPCFLRREGNSLAVENSLEEVAVRRWILPQDRVRTSLARDSPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMB9</accession>
    <name>K1VMB9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMB9"/>
    <dbReference type="HOGENOM" id="CLU_785707_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMB9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39507" checksum="F71A29964EB26FD9" modified="2012-11-28" version="1">MLDWKYFPHIFDHIYDYLDADGMNVLRLTCTTLRHRVEIDLWEHITVSHGIMMCTTSDHHSRTEALVYTRPQTYSTRYGCPLPRAYQDGHPQITKTVNVVHHPGRAGKGGISHCEDDRPEDHEWCCDSACPTADILECISTAIGARVAVQLLYPNTYRCSDLSFTCHFGGFHSCITAFPLKALINSGPDYMIDVAAPQHIFKLAYPPRGLATAGTVDFIKELIFKIHHIIVLLYPESSDDCGNESACYHPSGVKPFVEGIVPCATESFVNKVTCVAIESWPPDAPRGPRLLTPHTTSKAFRVALKASKESYRATQPDKVIFFNNINVISWEQLREQVGETTCSLLAKDIPPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMH1</accession>
    <name>K1VMH1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multi-sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000103">
        <property type="protein sequence ID" value="EKD05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMH1"/>
    <dbReference type="STRING" id="1220162.K1VMH1"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334058_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMH1"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF5">
        <property type="entry name" value="HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="248"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="641"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="761"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="780"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="855" mass="92945" checksum="DE8A828C3F3230F1" modified="2012-11-28" version="1">MPDHIPVARRPSMSTLSVTGETMTTSSQAPNGGGETLSSSQDTQTLSERDQLDTLALMRSSLALAQEKDSLVLLCTLLKILCQFMRCDYAAIGLTDEGDRSVLRLKAAGPFQRILPYDLDVAEVSAQTVCPTSIMLHVSRTGIPITQPAKAFRLRNDPFFDDRQPRMLMCLPVINQGIQSGVILLMSMSNAATALQSESAREVISTLATFAYIIHMHHVFTSRLKTEVTMRTRELTAALQAKTLFLSQCSHELRSPLAAIMGLAAVLENSAGLTPVQREHLGTILTSGNDLLALISNILDHSKLESNSVLLEHIPFSVRDVVESALDTVAPVAQSKNVELTVLSIFRNDPPGLLGDPFRVKQVVLNLLSNAVKFTPPGERGKRTARVTVERMWEDLGDGQIKIILAVEDTGVGIPASKLNKLFKSFSQVDESITRSYGGSGLGLVISRDLACLLGGDCTVESEFGKGSKFTFSFVGTRDPNWKPTVIRRFPQPKRIFVLCSRDMVWGRLLEEDSKEFNCIPTRFVDDAKLALDPGRVNGLNSGIEYAFILIDAPAVDLETLTRMRELQPRAKFLFVTRITEIAAEMDRLQLSRESILARPLKFKSVHDAIIPEDTPKGGNLPAPKAKRPINKQLGKDKPLTVLVVDDAPVNIQVCRRILELYGYKDVDSATDGLQATELAEKRRYDLILLDLQMPVLDGFGALERIKASPLAGEPCCVSLSANVDKATRDRCSDVGFFAVLDKPVDIPRLGEILIKVHNHRNGLPTDQPTSPKVSALLSPKTSPTLSPKVSHSDSATPKPSVNCTASSPTLSPKASRGDQITSTAQSNDAEPPSPSATPKPTPAVNANASANGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMM3</accession>
    <name>K1VMM3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMM3"/>
    <dbReference type="STRING" id="1220162.K1VMM3"/>
    <dbReference type="HOGENOM" id="CLU_041051_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMM3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="442" mass="48387" checksum="D142AD4534DCAC10" modified="2012-11-28" version="1">MFAYRVFHLANALRPSLVRGAHFASFNIRSDYLQRIRHLNIHQLLVMPLSLAYNDYPQALDSVVAHLSCDDQVRLRLVCKAFLRAVDNILKHHLILFPNGAKISVQGVAHRIPGLKSLDLSNPGEIPEAHVLDVRGYFPPSVDLSKLKESFPSLQVLRMTNSRGRLKSYTPYVPVPSRTVVLFTNPNGFECNPTPRAGWGGHDRTAHLPAGLEDVLPDTVSKVVVNMNGDDIPVADMWRAIHRPAPHVKEVIIVIPRYSSLDDPGALGTFNEPIVGMDVADLIVGAPHGFVGSAATAPTAPTAKFTIVGLEAVSVPNYAEHFRAVLREHLSANRFEDVDYGASGPAVIHGEGGPVFVPATGQAKAAHDAKVESILHMVDMVTKEGYVKRVGRETALLELVEKLEKNHTRQHCQPAAPAKIQGDVGVFRGWMGLFDEIFSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMT9</accession>
    <name>K1VMT9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMT9"/>
    <dbReference type="FunCoup" id="K1VMT9">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMT9"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMT9"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="262" mass="29744" checksum="5F9E804682B97DF6" modified="2012-11-28" version="1">MSWGGFKKAASRAGTQLMQKTGQVERTVDHQFAEEEAKYRIMEKECNNLQKEAKNYLDAMRTMSASQNRIAETVELFYTADKASDGAMAGHSYKAAVDALDDVVTRDLDGPYRATVLEPVGKMCHYFNNVNAAIDKRNHKLIDYDASRSKVRKLVEKPSDDTAKLPRAQSEHDEAREIYDILNEQLIAELPQLVELRVPFLDPSFESMVRIQMRFAEEGYEKLAGVQRYFADGIRDEYANGQLDVQVENVLAEMKELAIYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN50</accession>
    <name>K1VN50_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN50"/>
    <dbReference type="HOGENOM" id="CLU_491064_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN50"/>
    <dbReference type="OrthoDB" id="2588667at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61054" checksum="BA6BC83B92CC3FB3" modified="2012-11-28" version="1">MSANTSSTGSEADFEKKGPQAPVQVLDVPAHEFAHKKYSLKALWHWLGDRDIHVWIMSLGFTLLFTSYPIQGVQTIRFPDTGAYILIVLYSAYFVTSMWATFFLSWWGLEFCLIWGPISYGTWIACMFANNNAANLVGAAFFGWGAGILWPAAGQLIAACSTPHNRASNAGIYQCAFHLGVFAGGLILGGVQKGLPNWNHQYAVFLGLCGTSVICFFIHAISFRRRFRGHKTAASAAHVEQQPDVELHRVKLDDGTVEYRRVEKADLKNENAVVQDLALSGGSGSTGSKLAAWKANFWNPVKMLWHPVFGPLGPSIFVTGGMTQGWFNASFNKIVNKVGGDWNGWIYAISESWALVAAILFGIFYDRLRTRYVASKFRWIMYIYIGAYYCLCGLALAAYYMGEKGVGSEPGMTRPSHYKAVLSFAGAFYNIQLLALEVSILTYLSTFLTYNADVAFSSKIGCEAGGYLLVFGLVNVLNPKWMIVLLFCCGPPAHIVYLIWWHAPDRPVAEILESANSSQTAISTPVAESVDEKVVESPAQSPSQPAQATVHVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP05</accession>
    <name>K1VP05_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP05"/>
    <dbReference type="FunCoup" id="K1VP05">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP05"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP05"/>
    <dbReference type="OMA" id="VCIRVYT"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="164" mass="17642" checksum="D0997585BECE0A80" modified="2012-11-28" version="1">MFRVNAFAASFRALSVRPVASSSRLVLPAKPAAFSTSAPLGLTANQLIRGDRKHKTKQSKAPLLEGCPQKKGVVSKVYTTKPRKPNSAVRKVCRVKLSTGKSTIAYIPGEGHNLQEHQVVLIRGGRTKDLPGIRYKVVRGALDLPGVAGRTSSRSKYGAKKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP13</accession>
    <name>K1VP13_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000288">
        <property type="protein sequence ID" value="EKD02371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP13"/>
    <dbReference type="HOGENOM" id="CLU_1316230_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP13"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="209" mass="22542" checksum="E432CCCC8712523A" modified="2012-11-28" version="1">MRVAAQLTSTAAYMVGLSVRERHVIQSLVELTRQLEDVDREFTAQMLSMEYKMTGALVNYSKSLHVDEPEENLSSHVSTASISASELSYVREAPAKPHKPQPHRLVNDLVLLDRGQLSPSMTVAVGNVDRSAPELQNTEDDPDTPRRSSGDSGNSSPASPLIATPNAVVNVSASPAPLLPLTVDREGDKPSDLGSLPKSNSIPRLLQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP17</accession>
    <name>K1VP17_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit alpha, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_03328</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000288">
        <property type="protein sequence ID" value="EKD02376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP17"/>
    <dbReference type="FunCoup" id="K1VP17">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP17"/>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_1"/>
    <dbReference type="InParanoid" id="K1VP17"/>
    <dbReference type="OMA" id="NETKMEP"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854270" description="ATP synthase subunit alpha, mitochondrial" evidence="14">
        <location>
            <begin position="18"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="17">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="15">
        <location>
            <begin position="324"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="16">
        <location>
            <begin position="554"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD02376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="687" mass="74225" checksum="278253B1750A97C2" modified="2012-11-28" version="1">MHAALTALTALLAGAIADRNTAAGSNRPANENAGRGSSQLPQATEPQFSGTIRVPPPTLAPPTPDPRDTGSNSSRPSHLFLLRQNPSPLPPHPHTPYTAHHAVRHPELAPRQSERKGPLEFGSAEKAKGAFGDMAHGRIQQQLHSTILFAMPAHRLLRRDAPVRARVPAVRTYATAKAAASEVSNILENRIAGTNAGGDVQETGRVLTIGDGIARVYGLRNVQAEEMVEFSSGVRGMCLNLEADNVGVTIFGNDRLIKEGDTVKRTGEIVDVPVGPGLLGRVVDALGNPIDGKGPIDAIGRTKAQVKAPGILPRRSVNEPMQTGMKSVDSLVPIGRGQRELIIGDRQTGKSAVAIDTILNQKSWNDGNDEKKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYLAPFSGCAMGEWFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNEKYGGGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFKGIRPAINVGLSVSRVGSAAQTKLMKSVAGSLKLYLAQYREVAAFAQFGSDLDASTRFLLNRGARLTELLKQPQYSPMPVEIQAPLIYAGVQGLLDQVPTDQITTWEKQFTEALKSQHQDLLQKLSGGVLTPEIEKEMRKVIEDNVSDFLAKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP66</accession>
    <name>K1VP66_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1764-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP66"/>
    <dbReference type="eggNOG" id="ENOG502SCT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103523_1_1_1"/>
    <dbReference type="InParanoid" id="K1VP66"/>
    <dbReference type="OMA" id="WNVYKAD"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19624" checksum="3C553D6889672DE6" modified="2012-11-28" version="1">MGKKDKKPATAVADTAADIDDIFAAPKKSKPAVAEQPSSSSKPSKSSSKDKSKSSEKSEKAEKKEKSDKKDKSEKKEKKRKSESEEPAKKKNKSERVVEEVVDPSLAVKAAVEKAKQKPVKAAKARGKEVEEDMAFRDSRGDAGRKRTEEGYLVFKEAELGIDPEAGGTPLCPFDCECCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPE7</accession>
    <name>K1VPE7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPE7"/>
    <dbReference type="STRING" id="1220162.K1VPE7"/>
    <dbReference type="eggNOG" id="ENOG502QUVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373058_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPE7"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="3">
        <location>
            <begin position="146"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="83346" checksum="FF534E5AFCD7BF9D" modified="2012-11-28" version="1">MFGSDQGPWNHTFRIEHKLGPRLRVVGVIDPDTARAERVLRKKCESFVKPAYEGAVVYSSLDDYYNKKTEAGLPDPRAFFVGTPPKFRGGTEPGHNDLELQMIKYFPNVAYFIEKPVSTAPLSEVNDVVQALKKNGNIISVGYMLRYLRAVQKMKQIIHDNKLTSAAYPSIAKPAWWNKAFDQGPVIEQGTHFCDLSRYFGGDVDLDSVKAHSVEWYEKPGVLSRIPVDESIVPEDQRIPRISAAVWKYDNGAVGSFMHTVAIHGTAYDCELEVWADGYHMHLVDPYNAPTLVIRRPGDDHEERHAFTDDDPFFSEISNFIDAVEGEGNPHILSSYEDAAKTLKVNARRPHVSPLLTRHFPLLLSPLQRHSATRAYSLAVLVAAVVALRHVDIVNRGQRKHSETSEDGVEDEDTVQRVRIPVDGDIALSGGQVADCARVLAYELRDIGRQRRGTKVSVQRGLKQRTAEGHAENLADRAEHYANLHFSLALALHVGHERDERAGQDTGVSESGGRLGDPENPVRAANPPREEHEAARKDDRSTEDHDAPVSSRVAHVPSDHERAKPNEHAEIREANEEGRAARHHAERQDRLGGILALDEEEEDERHGERKQQSQNERVSPSKLAAVRLRGRRLERDAEQKSADAHTQERSAQVVDLSQECQPWTLLPLSHVSGYEQRDEHERAEQQGYLRAEREAPAPAVRHPAAYRAAQCRAESLYVSSTNGPLTSKLLQTRPSSSLSYASPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPH8</accession>
    <name>K1VPH8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPH8"/>
    <dbReference type="STRING" id="1220162.K1VPH8"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025520_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPH8"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="613" mass="68285" checksum="19FC21056CF1E632" modified="2012-11-28" version="1">MSKDVSRSPPKPHVAAAVNTPQRRVLSGEGPSRRPTVLSPAYTSRRHSLYGIDDRVVIDPGSRVWKAGFSGEPDPRTCFWACDEKYPGEAWGLDISYTPGCRGNRSEGRRLVRARVEKRLREVFHKHLLTDGKARKVIVIESTFLPQLVKEEIARALFDNLKCCLHPFQSSRSSCVRQSYGSCGGLRMAGDNSHSGRMLHTRLRALLRHFGQYHSPSPEHAAAKYVPRHILTDTLVERVLTESCFLNSSPPAPSDPMDVDFQRDESSQDEAPAEVTPDMDDMDLMFALEERYSQSTAKDWTVTLSPRRGSGRCAVLIVPGWIREYVAEVLFGDGPSEEYSVPEIVLQTLRGLPIDTRTELASSILVAGGTASLPGFIPRLRNDIIRLLPPGELEQQSNDVRAEAAEWRKRSKDKYAHLHGLGSKIAIINDPAPGPNKSSGSAPRWTPAIIKTGAPEILREDYDQLCNEDEERGVAFGAMVEESRQGAPDPKVGLELSELRPGMATGPMAKRKFGWESEVLPDWTTSGTANVENNTPTAFQHRSSQPRMSVAQWRVFPQTEAVPQPQWRSPFRVASAERYEVISGRTNERAPGIRRVIVFHVHPVLLPVVRIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPI7</accession>
    <name>K1VPI7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPI7"/>
    <dbReference type="HOGENOM" id="CLU_696744_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPI7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="396" mass="43692" checksum="253B5B9EDC1A8FED" modified="2012-11-28" version="1">MEERKTLLDRTVAKSISDFEASEEFRLLSSDLMQERLLHLCREQMVAAAALNHPTQDQKLIEQLTFRNAQTLSDAGADLSDPFLPAITKLGAMTTFWALRSSGVLGTRVGYSGLSCYLNGETLERQATVYFLATQAGMVTTIGQDGLPYFDTLDVHYKNAQQTLKALDIKHKDPCWVSMEALYPTSAERLTLIILAALGGTSCDHWTPYQQLMGCFGASLVAEFFESVLNPWEPTRSISPPVITPVTESMQVAEDYLTQLASSQEEAPLHALHDVRGESQQASQASDCDKPTLFCTTGNDHTASHRRCIPKGLFDTVASWYRTLMGLPSSEAAEFLRSDIPNPLPSLVTDDHNDPIDVAAQREALFKRTLDAALAHASATEREELLAAFAQFKNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQB8</accession>
    <name>K1VQB8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06661</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQB8"/>
    <dbReference type="STRING" id="1220162.K1VQB8"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_2_1"/>
    <dbReference type="InParanoid" id="K1VQB8"/>
    <dbReference type="OMA" id="KQAMDKW"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="88"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="320" mass="34830" checksum="42D677F8430EA88A" modified="2012-11-28" version="1">MSPSPINQTSTSDNRSTLSPAIADEQMTKQDITLGPMPDAEGYFGQYGGSHIPPDLKAAMDDIAKAYEEITKRQDFQDELQLLQQTYTGRPSPVFHARRLSDKLGGAQIYLKREDLNHTGAHKINHCLGEALLAKFMGKKKVIAETGAGQHGVALATACALVGIPCEIHMGQVDIEKEHPNVTKIRLLGAKLVPVTFGQATLKEAVDSAFQEYLKNPTDYIYAIGSVVGPAPFPAMVRDFQSVVGREAREQFQKAYGKLPDHVVACVGGGSNAMGIFNRRLFHTVHACVIGFLGLYATECVRGIIMKDGPRRPNRSPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQG1</accession>
    <name>K1VQG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQG1"/>
    <dbReference type="HOGENOM" id="CLU_2361233_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQG1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="96" mass="11155" checksum="6D9AC802E71ECF70" modified="2012-11-28" version="1">MPPRLPPELLPRVLSTVDPAQIVDRRLLARVARSSRELYDLAMPLLYRELEFDDLRLLDFLACGRQLTRRDPEWGLFTAKEESEYPEEEMALGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR94</accession>
    <name>K1VR94_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein Pumilio</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR94"/>
    <dbReference type="FunCoup" id="K1VR94">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VR94"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004017_8_3_1"/>
    <dbReference type="InParanoid" id="K1VR94"/>
    <dbReference type="OMA" id="SHELMIN"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="299"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="574"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="643"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="711" mass="78182" checksum="22749D71495A4EDF" modified="2012-11-28" version="1">MSGAAATSWAQPASDSNDIASHMSNLSVDDYGSPHRQNASPGAPPPPGGPYANVHTPPRPAAAFNPYDPFIYYAGVDPSTFTPNGAGAPQGYPYADVTTPLQAMATGANVYGDPYPSPPETYGSHTPDARSPGQVPAALTAFQHQLAAATAGARSQQVYRPPHTGQQLQVPHQLPTPPQQGYYNYIERGVYWHPRQNSVSSRGGRGGKANPAQRHRAMNSINGSPSTRRNSQHGHQAQMAQPNHYPTLADYANHAQQYTLQSPPMSTFGSPPANTYALPSPYAPYSPPAFGYGRQLKRDDSSVVRSQRLEEFRSRKSSRLEFSIYGSICEFASDQHGSRFIQNKLETASPEERQKVFEEILPNAFSLMTDVFGNYVIQKLFEHGDAAQKAALIKKMEGQALFLSNHMYGCRVMQTALEHARTEDRAKLVAELDGHIIECVKSSNANHVIQRLITLDPPRGFMDAFIGHVRELSTHPFGCRVLQKSFEVLPPEKIRPLLDEMHTCSHELMINQFGNYVVQSVITEGEGRKHDRDLAVAEIKTRIFDLCRHKFASNVVEKALKHANPADKRELISEMIGDDSGENRIQTLLRDQYGNFPVQTALAEAEKDQRDKLLSIIIPLMPNLRHTPCGRRLEGRINELESKGELPSLTSGNAWESPTLSSESESNTPETPGAATQQTQAQVNGNAKGRRSSPAAANNKEEKQVLVDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRD1</accession>
    <name>K1VRD1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRD1"/>
    <dbReference type="STRING" id="1220162.K1VRD1"/>
    <dbReference type="eggNOG" id="ENOG502S6Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419893_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRD1"/>
    <dbReference type="OMA" id="VETKISW"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="653" mass="69723" checksum="FD6CC21AC9C8B386" modified="2012-11-28" version="1">MSEQRRSSSPLSSASPSPVQEPTANGDPPPAPLHLGPAADILDNDNDEGDLVGGSSPTTLTEPLTDSELTDDEDDVDDVPQQADGTAEEPGNDAQDEEEADAPAPDDTADETPVGKRPSKRQASPSPSLTPPPPSDPPHNDNLPSSPMEKEGDDDDEPMLEEGAEEDPETAPAEPVVKEEESHPADDEPEADGDITMRAEDNEEAADDAEGTITAAVTENEADVEDAAEPEEEPAAEEEEAAAEVEVEASAAPSRASGHHSSHAPGPSTAAIRAMVALEVKFAALRDRLYVERLEEAAKEEEMILNEARRERLHEIALRRYEESLADLKIWRDVETKISWQTWTRDQMHWEEFEQTWSKRRRLAREKNEIETPKVQRPVPKVEKPPKPFDWSPGPVPSRLTTEQGLADLSAIDAARQQQQQQQLSRHASPAMYGGYAGPSTSAYGYQAPGQHPASHLHIDDDPRRHHHYSAPVQVPRQQHRQMQPNVQAEPSAPSRSVASSSSSLPQSGPSRKTLGTEAFAVPRREVVPHTNGGGDKQHVNGHSQQPLGGGHGPSSQPSLGGDVKPSIQGSQQGGSGGERANASARFPGLADYLSGSATPPQNSFQHHLLNSSAAQNAGSKGAPAPPAMSASSGAPGALSSSSLGGISRMWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS96</accession>
    <name>K1VS96_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">A1Q2_06158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS96"/>
    <dbReference type="FunCoup" id="K1VS96">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS96"/>
    <dbReference type="eggNOG" id="KOG3154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035060_2_1_1"/>
    <dbReference type="InParanoid" id="K1VS96"/>
    <dbReference type="OMA" id="DCSWKSL"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="133"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="333" mass="36725" checksum="7C61B7D6E270BE8D" modified="2012-11-28" version="1">MGKPGKAKNAAPPTRGRGRGRGGSSRGGRGRGAPRGGGRMTRSSARDDPVPVIVDEDESDTTEDEDSSEEEESGSGSGSGSEEGEEQEQEVRVAVPVAMWDFDHCDPRRCSGKKLARHGLCTAMRVGQRFRGVVLTPKGKKPIAPCDDEVVMMSGLAVVEASWARLDEIPWGRIKGPHERLRKFTFARRELTSVPFLIATNPVNYGKPWRLNCVEALAAGFYITELTSRLSKFSWGHAFYKMNGRFIERYRTCNTHEEVQAMAEQIQDDLQAEYDKDKAEKAAYDDGDLLRANPNHAGWDEEDDTDDSEEAEGSDAERDDVEELVAGVEGTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSI7</accession>
    <name>K1VSI7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSI7"/>
    <dbReference type="FunCoup" id="K1VSI7">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSI7"/>
    <dbReference type="eggNOG" id="KOG3257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_1_0_1"/>
    <dbReference type="InParanoid" id="K1VSI7"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000005">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="146" mass="15323" checksum="E916C3162AB0F282" modified="2012-11-28" version="1">MSGKAAVTQIVKLLVPAGKATPSPPVGPALGARAVKAIDFCKEFNARTAHFKPDVPIPTLITINPDRTFSFTFKTPPVSYLLKKAAKIDKGSGAPGSDIVGEVSLKHVYEIAKVKCMDDALKALGEERVARSIVGSAKSLGINVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSP0</accession>
    <name>K1VSP0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSP0"/>
    <dbReference type="eggNOG" id="ENOG502SBFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035170_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSP0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852068" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="433" mass="45091" checksum="D56FB5E7DE431E7B" modified="2012-11-28" version="1">MKFAIALSLLAALASAATQKCNPAARHVSLVIDQSTSNQWTDDRNFRLEGAKQIVQSLTSKTEASPNNLEADSVAVVGFAWDAWQVLDFSDPTAASGAIESLRDNLKGGTNVGDGMRLAMQNLQNLSADQLSGHSAIVLFTDGEDTQGNKDAMQSALREAKAKGVRVSFVRLDSESGNPWLGLFKIGGDKNYIDAAMTESIISTGGTVSIVRNASNLQAFVDQVLKNGLTGDDGKCGGTTIENPGGVLKNDVTSIGLCSTNAQAVYTYKAEKNEKLTFGVGLTSKNNPVQLTVVYENKSTGERKEIKVNGSNASGTVEAFAQAGQDVTLTVNPSGASRDACQYHVGLKVTPGQGPQPTVVPTTSATPSTSTAPTTSATPTTSASQCPSVTASTTTVERTVVTTMTVPAPSPSASVCICKCGTEGSKPLPKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSW6</accession>
    <name>K1VSW6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSW6"/>
    <dbReference type="STRING" id="1220162.K1VSW6"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888995_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSW6"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="313" mass="34543" checksum="526D5D06852A4F93" modified="2012-11-28" version="1">MPPREQILGESASTIEARDDHGDEISSFFAETSQLTSVIPTKKRAFVEVLTRANEKLRSVFGLEIVELRARRKGDLDDPQTQAQTQAQTQRKKKRRRRKDDASDASGSEEEEEDGEMATAKALIAEMTKPNPLPLPEDEAAAEAAQADSGAVLQWEKADASQTGALGLLGIRTVILCIILSLGRSVPDDQLHSLLRRLGLHRDTVLPYASKDGTGEKLTLDKYLDLLARKRYLEKAESGGTGGQPKVIEWRWGAREAEFSEKAAGAFIEKIFFDQAESDSDDEDGEAIRAREANRKRVRNELERAAGGPLTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT29</accession>
    <name>K1VT29_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT29"/>
    <dbReference type="HOGENOM" id="CLU_1876893_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT29"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852079" evidence="2">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="136" mass="15168" checksum="FBCEF582DC679811" modified="2012-11-28" version="1">MKVIAPLVLALLAVVSAQPFQEGLAGRPAKRGHQAQLEKNDVYADKQAWKRTGDWHDHHGDKCSDFYCRLQCKEQGFCRSECRNGKCKCSVRRDQHGKCNVPSKKPHPPRPTNGHGHGNGHGRGHDHDEDGQGDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT85</accession>
    <name>K1VT85_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000357">
        <property type="protein sequence ID" value="EKC99902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT85"/>
    <dbReference type="STRING" id="1220162.K1VT85"/>
    <dbReference type="HOGENOM" id="CLU_1246127_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT85"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="222" mass="24334" checksum="52AF648C1B5D6C26" modified="2012-11-28" version="1">MRSRTLSKGLSVIRLRSDQQRQWANALVREAADSPSGESPLRDLLAGKVSGLELTPTLRWRALASLAALGKTDKSELDAEYKRDSTMTGATALARAEASFPGVEVKRRVWDELTTESLTNDRQGALIAGFAQGPSSDRKEFVAPYFANLTKWWKEMTMTMATRLARGVFPGSSIEEGKLGSNAVEKAAQAWLDQNENAAKSLRRIVIEGLAGLRRQLAAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTN8</accession>
    <name>K1VTN8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000351">
        <property type="protein sequence ID" value="EKD00058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTN8"/>
    <dbReference type="HOGENOM" id="CLU_1662049_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTN8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="17644" checksum="497674BB40B5E549" modified="2012-11-28" version="1">MPNSPTRATPSSRLELVQVNITEASSAAPRMGPISRHVFDALQEDNAKLAEAIRTRATRETNLRLLVRIQELGKEHGRKDLQSVIEKTTASLKELNTCLKQFALEDGIDATNGTVTFRRTVEALREVEDRVEELMRIAGDALKPMLLPGPTPETPSRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU67</accession>
    <name>K1VU67_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU67"/>
    <dbReference type="STRING" id="1220162.K1VU67"/>
    <dbReference type="eggNOG" id="ENOG502S81V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072561_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU67"/>
    <dbReference type="OMA" id="YKPMLEA"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852105" description="Alpha-acetolactate decarboxylase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="30808" checksum="B980E53D8AC6984E" modified="2012-11-28" version="1">MKLTAFVTVAALLGSAVAKPVPHRDESDDNDDKWDHWKGNKGKGHHRHGRPWVKANELHQYSNIAALTEGVAANGTLIDNVLKYGDLGLGTFGELRGEMIVVDGVVYHATADGQVSTPDPSETETPFMAVTQFEPEAETSVQVANMTDFSAQLPSWWGNITIRNQFVSYRLDGTFTLRIRAPPGQAYPMENLAGVSSRQVEWTHANVKGSMVGFHTPKYAGQINAAGDHLHFISEDRKIGGHVLEFKTEGEANIQLARMPSFHVEVPTDGQFTGIDLGTGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUI5</accession>
    <name>K1VUI5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUI5"/>
    <dbReference type="STRING" id="1220162.K1VUI5"/>
    <dbReference type="eggNOG" id="KOG4353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2428624_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUI5"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9877" checksum="EFE220352B49EB83" modified="2012-11-28" version="1">MTAFLEAMPLSRHDCQTLDCHPLKGAQAGAPELLLTVTGSVLHGPSVMKTGDNPNVDPSDMPRKFREVFVLRPVEAAEGMQPKSANFRFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUW6</accession>
    <name>K1VUW6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUW6"/>
    <dbReference type="FunCoup" id="K1VUW6">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUW6"/>
    <dbReference type="eggNOG" id="ENOG502QQ2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059017_1_0_1"/>
    <dbReference type="InParanoid" id="K1VUW6"/>
    <dbReference type="OMA" id="EATHLMK"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="333" mass="35898" checksum="DB611B7762290ADB" modified="2012-11-28" version="1">MQSWKTLSASLPSVDLSAASKNFRNTVQATRERFGNVAPEAITELPIEYKQLEARVDALKDVHQKMLKITKVYETETYDYPSDIAENVSELGHQAQAAWASFANKNLKNTSLPVPIPEEKQREHAPKTLPHALSRAAKSGAQELGAEDKLGAALATYATAMDKVSGSRAERACVSPETHRDAPSTSCVAWTKANTQVGDARLAQDSLIAERFVTPWQATLSTSIGLAMKARANVKTARLELDSARAALKSATPAKQEQARLHVEEAEDKLVQGTETAIGLMKAVLENTSAVGLRVETSAVGLRVETSAVVSLQAQAVTRRSAKGNRHCSAGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV78</accession>
    <name>K1VV78_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000252">
        <property type="protein sequence ID" value="EKD03402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV78"/>
    <dbReference type="STRING" id="1220162.K1VV78"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="InParanoid" id="K1VV78"/>
    <dbReference type="OMA" id="CMTADTG"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="122"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="497" mass="53665" checksum="14B8516B5E8E9BC6" modified="2012-11-28" version="1">MLPPIAWVSHDVMSGEVRRSPCSTRYGGSCAKVEQGRWDGSGGGAQIIIRFLVQISNQSTGDLKVETSQPSGTHSPSRRPRLTSITSLPLLTTQPIKDRRRIMADSTSGQHHWNGVLNNALEGVGNTPLIRLDKIAQAEGLKCNLLGKCEFMSAGGSVKDRIAKRMIEHAEKEGILIPGQSVVIEPTSEYSRNWSGANDEAATLRKTSDGSGIGLAMACAIKGYKCIITLPEKMSLEKEVMLRALGAEIVRTPTEAAWDSPESNIGLAAQLKEKIPGAVILDQYNNPNNPLAHELGTYPEIRYALKSSNLKRKDIAALVAGAGTGGTVTGLARGQRHAEKEDGVKKAVIVAVDPVGSILGGGEPGNYIVEGIGYDFYPGVLDRDESLIDKWFKVDDSEALPTAKRIVREEGLFIGGSSGSALAGALKFLKSEDGKVIGQDESANVVVIFPDSTRNYMSKPWFIKEEQETNPLREQLRSILGRDLDDPLRKRQANGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV79</accession>
    <name>K1VV79_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV79"/>
    <dbReference type="HOGENOM" id="CLU_1200545_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV79"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="24034" checksum="5648F5497E02E1CF" modified="2012-11-28" version="1">MLYPPHSSHGLHASADAVIKVRARLLLAHLVIVEQLLRLLFLVIAVGKELPAALIQQLLFTSTAVHARLGELEEGRGLLEHAEADADAALVAGGAGCVGPGVGRDARAGGAAQSQRGARVALARPDLGHALEHAPEDGGGWCQLPTKNIRAWMAVPAVLTDEGAVEDAIGDVGRVDGDEVGQTRHEEEVRPVRVLELHAVTRRAAGALLVVGQEDAALADAKPELALAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVC6</accession>
    <name>K1VVC6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVC6"/>
    <dbReference type="HOGENOM" id="CLU_582909_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVC6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="469" mass="51290" checksum="5B2D2F8E1B157272" modified="2012-11-28" version="1">MVHAIPLPLGSLFSRNRFDPRDYERTPLLEKLENKLEDKLERLRPEQQRLRRKAVVAKLWIIERLQRAKNSSHAARERIREASGGFADHLMSGSHTQPDNTDFMPTRPETRRKGHGRDDSETAANEWCLGAEFTDTYATFPRRRLRSNRLGRVRSLSGASTGSAESNIWQYRPYSPEAWSFPERPVFSDESRGRALSTGERRSIGASVGESKWCPHDARGRNSLHAEGSGITAASLREALYGAPCARTLSMSPTSPLEPLVELAELAEVDLTDASDASSETEIRTPASTPPNSDGYLSDPALSPTSPSSSTLSDPSNPYALSPKQRRAPPLPPRPSRLQLAAIDTAVMPTLSTPSAPSTPTTAENLTPPPALIPRPSLASLNSVNLSSSFPLSDREEFDDVLIWSDGEGEHTRSRRRSGAQKRVRFAAAPGVMEQHCNVYSTSSSSVNLAAQRSTSSTSVNLLSGVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVR1</accession>
    <name>K1VVR1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVR1"/>
    <dbReference type="STRING" id="1220162.K1VVR1"/>
    <dbReference type="HOGENOM" id="CLU_393888_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVR1"/>
    <dbReference type="OMA" id="ESEMIMM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="745" mass="82834" checksum="F3C54A2ECC348DC8" modified="2012-11-28" version="1">MEEEVDWGEGDGYSDDCLSLGGDDIDDVAAADTANDVTAAPADTKEDSKPIEQSKSDAASASAKAAKEPPTGPKAATQAQSTPTEQTKDDNAPPKPSSIDSQKPSTSSSSVNGHPGRPIANGRERLPPAAPRGGRHDRQRGIVDNRRDSRNQRLPAGPVRVRPREPSGPPPDTHEELRKPRGNEDRGAPLPVGWQRVWSNTQSKYFFHHPETGETTWERPKNEPERKPDASAPVPSRERSPRKRSRSRSPARHDREPPRGPSSSTENDGRPPRAWGPGSANATMSAPRMDDRRAPRDGRDRGWPQRPPVDDRRDARDARDARDGRPPREPRGRRDRDRRDERDREREREQQRRDEPRRDERPSETAPTSNSLPPKPEQPTAASATNEEAEALKARLRLKEELRKQEEEMRAAQERLRKLKEQEAQLEAGVKAQPPAAASGLPPKPSTDAYAGPSTTADTKAGPSPSAAPVAPARQPRGPPVEGNGFGPNTPNAPNAAGAGDNRPPPAYGPGARGSLPNRPFPLVPERPGLSRRDSRRRERENGGFDGRRGLGGADMYRPSGGRSPPRERGDRMDRERERERGMDRERERRDERRDDPRRDQHRRDETSHRERDRRPGEPARDAREPPRDARDAPRDAPRDAPRDAPRDARDAAREPPREPRGGDRGESQRERDAPNSRGPPAAPRESRESRDAPREGSGKPDSRGKSLSDRLGPPVDRKRREPEDGLPAGVHPDRLKRMRSPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVT7</accession>
    <name>K1VVT7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502TG1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247835_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVT7"/>
    <dbReference type="OMA" id="WWSTAKS"/>
    <dbReference type="OrthoDB" id="2596744at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        <location>
            <begin position="813"/>
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        <location>
            <begin position="946"/>
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        </location>
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            <begin position="1247"/>
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            <begin position="1359"/>
            <end position="1519"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
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            <begin position="323"/>
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        <location>
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        </location>
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        <location>
            <begin position="486"/>
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        </location>
    </feature>
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            <begin position="517"/>
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            <begin position="544"/>
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        <location>
            <begin position="768"/>
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        </location>
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        <location>
            <begin position="778"/>
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    </feature>
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        <location>
            <begin position="882"/>
            <end position="897"/>
        </location>
    </feature>
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        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
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        <location>
            <begin position="1087"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1436"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1473"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1519" mass="154932" checksum="B0E0783483AF4018" modified="2012-11-28" version="1">MANRVSGRFAPAPPPHVDLPTLPHPQVVDAGGFELTEEQLPDFAGEVIRATTAEPTTESAKEEERNDEQESDEMEVDGEVEGDAEPMEVEEVEATEGAEPQEPPKQPLLDLAESRRKAKAAEGTPAPPHEIECIARVTLQVGPMSFPNTELWVGQFVEEREGVGGTVRMRPPKAPKEPKPKEPREKPREKRPSEREPKKKEPKRPRTSATVPARPTPRPPAPAAAPPAARPPSQTPGAGPSTGPIPGAGVRYASRADIRVNAAASQHPWLSILIHKAARNVANKDELAKLGRVVGRLGRGEGVGEGPEMPGLPGGPTMAGLLPRPGAPGARPAPARPGAAAAQPAGVRPPAPGVRPPIAGARPPVAGAAAARPPAGVRPPATAAAAGIRPAAAATPAARPMTAGAPGARPPAAAAGVPARPPPATAAPSVRPAGVAAPGARPPGVAQPAAAPVSAAASAVRPPTATAAQSAAPATSAAPAVISPVPAAPQPTPAPAPSAPAPAPAPDQPQYTPAESDLSDLSDSDSDADLTGPPQSGGGPVPVPSATAEAPAHSASSAPEPAEAPTSTAETSADVEMADAASTEQEEAAIAAPAPPSAPPATAAASSANPPTQAAVSTAAPAASTVQPPAAVIPAPSTAQPAATAPSTGAPATPQVSTTPAATQPLSTPTSAQPSTPAPASQQPVNPSVQATSVSVPTAPAPPAPASSSATATTPASTATQATAAQTNHGSGPRTVPTIPVTPTPARPPNVAYYMPGQSTPQSGPGKVGASPSVSTPGPAPPPKPTYPLPPRFLLVAFKEAPTEKFLIPLGSNSYVSRVGGDYVTSPAPLPPQVKEPSPVKVEIKEEPESVSAPTTEAPAKKRTRASMAKPPPPKEPTPEPEPEKEPTPAPPKKDPYADLPVVPGMKPDSGTVLLSTYLPMNGWHKPDWTKFQKRLPFDNPKFVEKLKAPSTTEQSSPIKSPQSPKRDLRPVQKPAKPPVTTREGMLNLAAENYLPAEGKVEPITIRIVGLNDQNWKRFKGVMDEVEKCELEALAWAEPELNKNAPESKPVTPPVSQTAASSTPATEPVKGAAASVPADSTARPGDAAVPAVPAAPATPATAAPAPATPAPETPAASVTASAQAPTATQPHQTPAQTSTPAPVSAAPAVAPTPASAKTTETPTPATPKAAPPSPAPQKKTLAPEVRETWLSRKKERFTSLLNRVGERVFPRFRVESTIPLITEATADKWALRPYHMTTRPLYTRDAGDGEEEGEEFMPLSPELAAKRGRKDPEPTVTFEMPVSLDALDERVEAGAAVSLSRRGRGRGSAPVRKFRRGTAGAICEGCGKPGLKVWRRGPNGRGTLCNGCGDKFLAGTLGELKAPGAASQKDEDDEKEGTEGLEEKDGDEVKKEPKEAETEGADKAGETPAETAPDSLAETPAPKDAAPSETPAALEGPKEAEEAADGDEKMDQDGAAKEAKKDDVPSEAPSDQPAVASLPADAAAPHIEPVEPAAAPPEPEATTTTTVQPPTSDAMDVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW39</accession>
    <name>K1VW39_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000244">
        <property type="protein sequence ID" value="EKD03632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW39"/>
    <dbReference type="STRING" id="1220162.K1VW39"/>
    <dbReference type="eggNOG" id="KOG0713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278883_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW39"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="828"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1132" mass="123409" checksum="D080BB2DE1C23DA4" modified="2012-11-28" version="1">MAAAVSPLGTSPNNPNRPVSPPPIQPLSPSTPARSPAILAIQRAAPPSLNGTLDSVVSGRDLVAAHERDHKSVFIPEPLYTFLRSPDHTVTACLANSTVDTSVRVIAEHLFGLGNGSFGLWTGESVIRPKPPPTPKGVKRWLERLSLGRKQKNSKLKNRLGAADEGSKGQADSSTAASGCSDESDSDLSTEDHYSRMKLLSPPQLDEVRRCGQWRGSEPSTLFLNIYAQALMSLEKNVLNGMVSPPLMAGCGVVPVTVISHTSDIVQHYADLIVNAQREIIFTTNVWEASESSKTIVEAFRILSQRVADRNGEKIVVKIMYDRGAAEHSGAHQIVSAREYTSADIGLPAPDEIPNVQLEVQNYHIYPVGTFHQKCVVIDRKIALLSSNNVQNRSDVGFMAQYEGPIVQSFYDTTLLAWWTSFNPRPPLVYERIKYPAKLTAADFQFGAENPAVEPKGDLDVLAERTRQKLAEPTFSDSGSIGSGTLGDGVSSTKSREHNCGPPLQPVLLHKPHDPFPFALVNRTPRGRRGHGDAFVPQNQAWLAGFKFATKSVFLQTPTFSAKPVVAAALDAVRRGVLVEIYADLGYDEKSAGVRRVARAPRREPEHGGAWPGVQRRRVARHGRKVDRVCPAYADTDAECDAVSPRCLHREPRAVLALQVGYQPDPRAEEAHQPRRQVVLAPRAAAAEPPSRRRGCEVIEGVGRKCLLVEVKRSCFRESGGGKRAIVDTLRLSSSTSHPISLHLTSRLLRRRSKTTMSYLSPLLWAFLPPQLTQILLPFASQFLPFLFPPAPPGSQGYRRNYRLLFTTLVTLWLAYTFVTQSEDRGRSYYDVLGVGYGAGEAELKKAFRGLSRVYHPDRQGRLSEPEMEVANARFVAIRRAYEVLSEPTTRFVYDRFGPSVAACTSCKSLRDYMQSGLMSSVSFYIAAVSGLGILAIARAARDGAYWRFTVVGVLLALELAIVLAPGSPAATPSHDSNDASDPTPLDLASPPVSAAFVPFGLIGRVIGALLGRVFDSRPPFQVVRLLRALATDVGIAISQLAGIWADPPADPEAMARSNLALAKDVASQAGTALNSTVGPLLASGTSEDELKDKVSDRLLDSNAAKHPAVLPAYDTRMRQNMRDVHLLMRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWL0</accession>
    <name>K1VWL0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWL0"/>
    <dbReference type="STRING" id="1220162.K1VWL0"/>
    <dbReference type="eggNOG" id="ENOG502QWTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027723_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWL0"/>
    <dbReference type="OMA" id="PNDKEWM"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="461" mass="50700" checksum="212E671B58E5DB85" modified="2012-11-28" version="1">MAPYLFPYPVPGSVTFSTLLLDRSGTYTTQLAEATVARTRLQAALKAAADGQPGSSALAVLEVYHPYLLAIMSCIDGDDLLYKGDPVFPWRPALTSYHLSTPTLSLPTIQVEHYFVLLVHTIALANYAHSILDGLPQFEAKGGQAPIITKEDEQKTSAGLTRAVDLLSQAAGIAEYTAENITPQLDAGRTTTGGRLGKYRWPVETGGEAMTGLSMILLADAHVTAIRKLLLPILSHTLFAPPGPPLPASHPSPSLLGKLYLHVSNLYSSASSLLVIPTNQQSNSSGSLLRRKKSDEIDSIDEDLIVELKRYLKKEAKLSKGLSYKYLGIDEASKSLGQSLALLQESGRCLEDLKDSKLESKMKGLNFNKDKKKAEAVRNLRQSRIDREYYSVQAWLQANKKLNDTVNFERVPPFQEVVIPPGRPIFSAKKYTLPKLKFAPSHIEEEEEKQEAEYAGRGNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXA8</accession>
    <name>K1VXA8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_04232</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="AMBO01000315">
        <property type="protein sequence ID" value="EKD01483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXA8"/>
    <dbReference type="FunCoup" id="K1VXA8">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXA8"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515995_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXA8"/>
    <dbReference type="OMA" id="NYGLSIQ"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD01483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="528" mass="58339" checksum="1EC224DF50D6E07D" modified="2012-11-28" version="1">MATAVMASPPATPFAVVFDWGEEFGPYQSADSQAIAVGETERASARCLRSIADGACALDNPHNVTLPIVPDDPKARYTPTKEFVEAMVETFKNGGKMPKRVVWEIILGVKSVVDAEASLVEIEVPKGVTCDIVGDTHGQFYDLHNLLSIIKPPSDDHMVIFNGDFVDRGSWSVEVVLTLFAYKWLYPERVFLNRGNHETADMNKVYGFEGECKAKHGEMTYQLFADVFTALPLATLVTASQPPKSLKSEGSQPAILHDGHKRYFVVHGGPPVSKDGVKLEEVKAIDRYGRQPGQEGLMCELLWTDPQEMPGRGPSKRGVGLGFGPDVTRRWCELNEVTAVIRSHEVRQDGYAIEHDGLCITTFSCPNYCDSTGNQAAYVKMQDDGTLSYHQFSAVPHPDMKPMAYSQGFGFMAKPGTYPYPKLCAISNNSATLSRNKAHSVPNSMFGNSARTNANAPRHEPAKGARASRRMTFAAQRKLEREKTEWQVVPQLGKREGRRRRKRMPRVRKAREVERAEGSLVSGVSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXK1</accession>
    <name>K1VXK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXK1"/>
    <dbReference type="STRING" id="1220162.K1VXK1"/>
    <dbReference type="HOGENOM" id="CLU_883356_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXK1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854435" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="133"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="315" mass="30160" checksum="5C1D9FE3BB9B264F" modified="2012-11-28" version="1">MKYSLVAALVAASVALAEPVDPNTIDPCLKNCAETAATAGSVGCSSIFDTACVCGKKDAFVAAATPCVLSGCADKAGEAIAMVSTLCTEGIKGGGDQQSSAAPEPTSSEETKPEPSSEAPPAPSSDAGEQSSEAPAPTSSAGETKPSAGGEGETIEGLSPCASKCMVEGAAKQGCKGQDDTACICTDAFKTAVTPCVAACGADDVTAALALSAKKCAAPTSGEAKPSASASGSGGATKPTSGGEAECDPRGGSGACAKKYTEAGTLTKSEDKPAETSQAAAAGAEADAAKQGSGAKALTTGAALTIAGVIAAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYT2</accession>
    <name>K1VYT2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYT2"/>
    <dbReference type="eggNOG" id="ENOG502RUZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253423_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYT2"/>
    <dbReference type="OMA" id="EHSEVKH"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1416" mass="155108" checksum="2E6C850528DB7D87" modified="2012-11-28" version="1">MGKDKKNPPGGLDKTPMPPSVGETYTLKVTFHGATNLPPADWGDSADPFILAQINTPLHTRNKHDPHVRFRSATSYKTLDPRWEAVWVVAGIPTPGAEFKIRVYDEDSGSHDDELGKVHVHTGRLSADYVGLDRQTFDLSSRGASVKAWGRKACMKPFSSDARKDATITISIENLGRTNPEVGKVYTANSFYWVHFSAILGHITDTVAPDPDAGGTEDPDFQANELQLAGPAPNALYHRYVEFLPFVKTMFQAKHLRGKLMHELLHREHEKVYHFDPKTRYGTLRNGHERARRFLDMAHWGEGDRVFTYVVTLDGLMRFTETGPEFGIDMLSKHTMHSDVDEWICVSGEFFIRKYKPGDPDGDMVKGVTSSVGDDKAQGIKPAVEKDIQQLKINTQYDGGDSEGGNGEEGERRGPMEVKSPSEVGMPSRSGHKRSDSRQSGYYTPPEYDEKPGVAAVVGGHRKSNSASRGGPNAAGPEFGDDGQPRASDEYRGHQRTGSNWGAESQRTITRDGPNGSALGNTVNDFPTPPNVDRSTTATPGHANATVATGAQTPAAYNAQPGSGALVGPNVPASATGPDGLPTSNAIDVFGGAPIDGNGLKGRRGYIATRTVETELPNGRRIVETSRVEVVHRKGEPPQEHREFERHEISPKPRALPLPPDGKPDGPLSPSSRKMSLPSVPGSPGTTPGVMSPGLSGMGSPTLSAVAAPIAIQSVTTPGAGEGAHIEEINDEDDKPNGVKGIDSVPEARLRDPKQSARVNRPPSHASVHGSMHESMYAGIDNRASGASFEQRPSTDNRRSTDRRQSTDRRKSTDKPSSPVAAMSPVNGGESRPRSLAGPEHHYHHPGSDGSSVSEDQHLHDAHLDVNGHPQSAFREDGDILLAQQRKNKNPLLSTKLDKHAARHQRDKPSTAPQLPPQQQSSVRVPLTTEALEHHNSMGKKGSPTSPKKSSPKKDKKSPTTDADAIKASLIPQAPAKKRDSSGYKIVDNPRYSTSQGQLASAGNSPEKPKGPQHQPLLGAGGQPIGRVAEHPPQIDVMSLNTTPEFVERDPHGKTVGVLTGPAKPSALELSDSDDDVPQGGFLVYTNERDGKPVEADPYGEKARKRAEEARKQAEADERQRQADEKAAQEAEKERQRQAKIDAKQSKKDRKAQEKQEKQERKQREKEEKEERKQREREQREQADAVQREKEQKQRQEQEKAKAAQAMRENAETGERARANSMEKAPVPGVQGVGVGGGVGAGHKAAPHGKTEPHHEHHRHKHERHDSARKEKHVHPVETNWILGPENGGSTDPSDYQLIIDNDSGTYRPDKQIMPLFEAWLKQEFPGLHVMAMSCDDDRLQNMKKKRQEKKKERNKGRVWERRGSHGSMSSISSSDEDDIEAGRAPVGKKEKRFDFLEHPGQTLREKVKQHGDTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0H4</accession>
    <name>K1W0H4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0H4"/>
    <dbReference type="HOGENOM" id="CLU_562823_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0H4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="54290" checksum="835E4BC2D18ACB16" modified="2012-11-28" version="1">MTSYQTNELFRTLTNALAEVAAIPDLHAEKKWILTIAAFAAKLIQDRDNFGEPRKTEPTSPRLLEPVKASPAELEGHFQQYNYHGNKVGWNNRVDDEARDIRRRFRGRAPQRLQEDTLITLPGKNYDYFQWPYQLPITWAGVRKGDQLLKLDQWRTNLAKHLPSAHRLDSVSPCRLEEFDASRFGTETFQTFEPQTPCPNMPPHDKGSKSSWTIPSRPLLSHIWAGSIFPAHCYHMRSADVSALRLLLEILGGVLRQLALNSPQFKIPTPAVAEESDMAALVVSCAYVVSEWKDQALSAPPSGASYLSSGLITSALRRWYQCWTSSPSSSDGLSSPAELPLCHVFDHLEEGICHHRARLEKQKQEEREAAARALHWNLANNAVVASRNVSRSATQETPPHEAKAAAYLALFGNDIFGVDSSSLPKIAQIISTALIAKLPSEDKELAIVGALEMIHRTGMYAERVRAMPAITAAIRPWDWRSAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1W107</accession>
    <name>K1W107_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W107"/>
    <dbReference type="STRING" id="1220162.K1W107"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853072_0_0_1"/>
    <dbReference type="InParanoid" id="K1W107"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="326" mass="36655" checksum="7C07174C42107BE3" modified="2012-11-28" version="1">MGRKKIEIKPLTDERNRNVTFLKRKAGLMKKAYELSVLCGANVSLLIFSSNGKPYEFSSADFDSEIDRYNEYEGTIERRRGAEFEAMINDDDDDDEGGAGNDDGEQQPKKGPAKSLKGKESYKKRRVAWREPKRDESFVGSLLDDRERERERDYERKREREESPSVAGLSYALGLQQQQPQYQRASYPAYPPQVPNNYLPTPGGLGGDMGLTTYAWLHMQQAHQEQKRALLEQQQQQLLKLTSCSSSNSFLRDILGGAGQMGLPPQQGQQEFVWPTAAHGEQERMHAAQQQQGGAGGVTTPPEEDLIWALANGAGPSERGVKRMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W196</accession>
    <name>K1W196_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W196"/>
    <dbReference type="FunCoup" id="K1W196">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W196"/>
    <dbReference type="eggNOG" id="KOG3318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098404_1_2_1"/>
    <dbReference type="InParanoid" id="K1W196"/>
    <dbReference type="OMA" id="QQTFKVI"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="179" mass="19317" checksum="C912B44BD1D77FD1" modified="2012-11-28" version="1">MSVDYHTGASVSKSLPNPPGFAVSAAGGKVASGTTKKQNVGNANELKLKRAWEMAFAPAKSLPMQAIMLYFSGSGIQIFSLGMIFMLLTTPITAISNVFRTFEPLRTTNSKGELTYALIIPPMILYVACQLAVFGLGLYKCWTMGVLPTGRADWLQFETRPSPPEWSAVRGAALSMFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2024-01-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1E1</accession>
    <name>K1W1E1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1E1"/>
    <dbReference type="STRING" id="1220162.K1W1E1"/>
    <dbReference type="HOGENOM" id="CLU_2063123_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1E1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="119" mass="12857" checksum="30B452FDC6F14330" modified="2012-11-28" version="1">MRPPFTRTAGSLLRRQAPVASSSLLSRRAYASAAAAEVPAQVTTLPNKVRVATENIPGHFHSVGVYVDAGSSVQEHEQAHRRRDDRARRPARLADDVLVLARDDHVPVYRLPSVAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1F2</accession>
    <name>K1W1F2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1F2"/>
    <dbReference type="STRING" id="1220162.K1W1F2"/>
    <dbReference type="HOGENOM" id="CLU_063146_1_1_1"/>
    <dbReference type="InParanoid" id="K1W1F2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="205" mass="22083" checksum="A7FCB7C5C84D007A" modified="2012-11-28" version="1">MSNNNYDSIKLVAVSPPIDVYGRVRNEPVTLVLRENLYADSPTDYAICDLNGDVVLASTDAAAVVDSAGQELYEIHDKIFTVHASMVGKKEGVQLFKVEDESKAEGGARAKVILSDVVTKSGSEQTMELDGDWAGDGAVLSFYDKSTKKPTQPVAKASRKSMTVKPGAYDDQTYFFTVAPGIDIALMAGIAVCFDEIRRGLEYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1N7</accession>
    <name>K1W1N7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_02832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1N7"/>
    <dbReference type="STRING" id="1220162.K1W1N7"/>
    <dbReference type="HOGENOM" id="CLU_505462_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1N7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="539" mass="59183" checksum="91DDA48EF5540E3B" modified="2012-11-28" version="1">MDFDIVPFEDIVWGPRIGGGSFGSVYRGQYLGIDIAIKEIHSSTQYDGYMSPEIIMGEDFDLPTDIYSMGIIFLELCTRILISSKIYHPETKKKPPVFVPDRNELLKHLDTGCPLEFFELALHCLSFTAADRPVVTEVLHRLEVMYASCVSRMDGGDEPMAVEQPTSPTSPTSPGQIRKGKRRAMPIFDHEGSSERAEKEVEMEIGGFSDSSSDSDEGEEPRRGRQREQKHIQTIANKHVRIEGDGAIRRRKTRRRTVTQEWLDAQTRTRSSSPSVRSSNRDYVHAESSTASEETARQGLLDSPVSAGTTAAATALTNVSSPVDITMPCAYPPSPPEETCSTFTIRGAAEPIAAPPTPASPPADSPRPLRPPPGPLRSPPPAPIQVPHSPQSLVTELPSPGTPQSPQFPQPLQLQQSLAPLQRRQSARDNSTPKSPTLPARNLIQHKFTISAKSSTTMAAVLQGTKRIPSTLISASPNWANIFYSSSSSRNKCKVCAKKLGLNYLQCNDCHALIHTKCKSVEYNFLCTSFPAQQLEPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3X0</accession>
    <name>K1W3X0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3X0"/>
    <dbReference type="STRING" id="1220162.K1W3X0"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015435_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3X0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="784" mass="82625" checksum="DAA209F107375E52" modified="2012-11-28" version="1">MTIGRGHDLPHAGPSHLGFAPRLPERVERAAERAERAERERHDRFDNPDRAHPTHSASAPGSASASSPASSASAAMHRRPTNPSYGAPLSALLPLLQRGGRNGHAGHSHTTFASHAHTHNGHREMNPYARPITHPRHPSATASATPASPAGPSISAGGTPTASGSASGSRPVQRSRNGCYTCRKRKVKCDERTPICIKCEYSGRGCEWPPEDPVIRRKNRPRKMKLHLVSDSKPASSPPAAPPAPPPPLTEDAKRTLRVPIHALQAFAATLPKLPRDRGYDTGPAGIAGTMTGMQGLKGLKGMGERMMPRRLRAGLMTDAAFLAPYFPQVDERLIFRHFVHHTAPLGLARDDPDPKRTWNPWVSLLAPLAFVHLPGESPAGDALRAALLAIGSVHLHYLSDPLDSLGAGKIIALARPTILGLVRSSLNTSSTPPSGVELDLILGSLLGLCVASALSADSAWSPLLRDVVGLLTDLGGAAHLLSTAPKDQLSIRRFVLEQLAVRDVLGCMAEIAGSGEPMLLKAGRDRAFAGVFFDAAAWSATDEEWESVERGFGVSRTLVDLIAKTSTLVAHVRGGQAESPTAERPGSRDSAAGAGAGSGSGVGEKPDGAKDGAQSGGGGEESLEAEADSLMAELKVWDESAKFSPWHQRTAYGNAAHRHALTIRLIRDVFNCPASDRRVQAAAKAVLELAVEAVSTFGSVVWLAWPVVLAGCQLARTDPAREVVMNLLGNTSRRACFDLDAARELVVAHWRRCDAEALAAVAAAAGAGASGTAGENGKKAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5T0</accession>
    <name>K1W5T0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000228">
        <property type="protein sequence ID" value="EKD04278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5T0"/>
    <dbReference type="HOGENOM" id="CLU_1846504_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5T0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="139" mass="15917" checksum="54D34A4C761E7D7F" modified="2012-11-28" version="1">MTAPLRFLPRISVSCFQRRLAANTSTLHISSWTNNLKVVDLEDSKSPPPPMRQWLRLPPNRTPFISVVVDPPSPVDTAFQINSQRGPTRRQQNIPVDAHGRLLSLSRHHSPSLLPIPVQHLYFQGRLSRHFFASYQHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6D0</accession>
    <name>K1W6D0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette (ABC) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_08261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6D0"/>
    <dbReference type="FunCoup" id="K1W6D0">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6D0"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="InParanoid" id="K1W6D0"/>
    <dbReference type="OMA" id="MYTGHTL"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000085">
        <property type="entry name" value="Probable ATP-binding cassette (ABC) transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="115"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="425"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC97338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="684" mass="73246" checksum="07EB61890097CF24" modified="2012-11-28" version="1">MLPSGIALGLRLGIAPRPCRLRLSPRALRVNSSVGRVGLGLRFNSSVPQKSTTSDEQTKSAVAEANEEPRKGIFSRISSALSLKNVGPQDTSETGQSSVKQLFQLAKPERKTLGIAVGLLCISSSVSMLVPLTIANDQTTFLGMSFPVAATLLTTAFFVGATANAGRVVLMRTAGQRIIARIRNAAYDSTLRQEPEFASRSAGDIVSRLNADANILGDSVTSNLSDGLRAIISATVGICAMFWISSQLTLIMLCVVPPISIGAVVYGKYLRKLSKMTQESLGDMSKTAEEKLNAFKTVTAYNAQPLEANSFAQKVNNVFQLSKREALASGIFFGATGLTGNLAMLCLLSYGGHLVSTGAITVGDLTSLLIYSGYVGSSVSGLTSFFSGIMKGVGAGSRVFHLIDRQSEIPLGVGQTLSSVRNGPIEFENVRFTYPSRKEVEVLRGINLKVEPGTSVALVGTSGSGKSSILTLLDRFYDPSHGRITFDGTDIKNFTPESWRARLGVVFQDPILFEGTVAQNIAYGHPNATREEIEEAARAANCNFIWDLPQGFDTMLGKASLSGGQKQRISIARALVGNPSVLLLDEATSALDSGSEDSVNSAIDDIIHQKNITVVLAAHRLSSIARAERVVVLENGVVSEEGTYKELAKDEKSRFRHLMAAQLLLEQGKEKEQDAKEMARVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6H1</accession>
    <name>K1W6H1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6H1"/>
    <dbReference type="HOGENOM" id="CLU_2401239_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6H1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="93" mass="10091" checksum="4DE9CD2055F809C1" modified="2012-11-28" version="1">MSANSNTNTNTGAQGQQRPPHHHLTSQQLDELSADAAEFPEVEAPKQKPVVGYGDLPNITRVPTEKDHENVAKDTLDQMVATLETDKAQKGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6I9</accession>
    <name>K1W6I9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6I9"/>
    <dbReference type="HOGENOM" id="CLU_1511652_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6I9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="178" mass="19861" checksum="015A89FC84626FEB" modified="2012-11-28" version="1">MRVAMRASSSALRSDNKVLKALIRSLRMPVEKDLPGYFRLEPCSESTARECLDLSRLPIPDPGALPNMFFTGQVLDQKLMPRQGARLAGVASMCPDGAVSITFRFMRVSEGDVVRFPDNGLIVRATRVGLESPLGFLGTSNVRRQGNAWRFKHEDFAWVFPFQGENTDSKPCPVRMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W765</accession>
    <name>K1W765_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aerobic respiration-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W765"/>
    <dbReference type="FunCoup" id="K1W765">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W765"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072692_0_0_1"/>
    <dbReference type="InParanoid" id="K1W765"/>
    <dbReference type="OMA" id="RWLNNVK"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="26876" checksum="E15EB38F1C3D6A34" modified="2012-11-28" version="1">MSALRALRPALRSVRAAQVARVAVAARPVAMRAFSVSFPARGSGESDGELAAALASEHAYETEAASDEKPAFLKELLNEGVWSLADEPANDDVVLTRKFGDETIKLTFQVSDLDESEPMDGVDSNGEAIDGVSPPCITTTCLLSKSASPKSLLIDLGAHPDGFEITNVAIYDKALAEKTGADADWTRRSLYMGPHYDTLDTSVQDAFAGFLAERGVDEALSNFIVQYCEYKEQKDYISWLAGVKDFIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7Q3</accession>
    <name>K1W7Q3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GrpE protein homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_08029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7Q3"/>
    <dbReference type="FunCoup" id="K1W7Q3">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W7Q3"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_6_2_1"/>
    <dbReference type="InParanoid" id="K1W7Q3"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC97648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="218" mass="23847" checksum="78D54C38723186A5" modified="2012-11-28" version="1">MFSRSIVGSFRQAAARPAVMARPAVARAVAVRGYSDAAEAKDEKKAEEGQSDEAKKIAELEEKLKESTKEMQYLRADYQTVVRRGQEEKAKAADFAIAKFARALLSTSDVLSQALKHVPQPVDKGTPLADLVTGVELTQKALNQTFNLHGITPMGDLVGEQFDPNNHEAIFQVPAAVAPKRPDGSDRQPGEIIEVQKLGWLIKDRTLRPAEVGVVQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W909</accession>
    <name>K1W909_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W909"/>
    <dbReference type="FunCoup" id="K1W909">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W909"/>
    <dbReference type="eggNOG" id="KOG2597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_0_1"/>
    <dbReference type="InParanoid" id="K1W909"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854276" evidence="5">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M17 leucyl aminopeptidase N-terminal" evidence="7">
        <location>
            <begin position="94"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="6">
        <location>
            <begin position="213"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="528" mass="56030" checksum="47D5EF201684D1A0" modified="2012-11-28" version="1">MRLASLVLSAVGTLAALPLAAGTYIRQPHDLEPFRLFRRTGGDSNRPEVTVSPDKNTGAGAAVFFAQAKSDGSVDILGDALSAQRTAQIKKFFPVFGFTGAEDSTVKIPGEEGDPASLLIFTGVGNEMDKNTTRGAAAFGVRAAYGVTTKVAIMVPKTHDDVIASAADGAVSGTYVWNKYKSNAPPRVDCIIIVSDCDPAKIVHDVTASLYVNYARDLVNEPANVLNPETFAQLASDIATPAGIAVEIWDEKRLAAERLDAILAVGAGSENKPRLVKLSYTPGGGKRNNWRHVVLVGGGITFDSGGLSAKSTADMSNQRGDMAGAAAVFKTILAAHELKVNTRITAWLPLAENMPGGGGMRIGDIVRTYANKTVEIVDTDNESRLLMVDAIAFAMQEEHDILVDISTYSSSGDQNTHAEYNGDNFRCEPDMDCAYSPVGKRDAADADGNSAADTTNSGTPLAFLYRFPGMSSSWGRYAKRDNYNPPKLVHINLGAMGWNPGRPYADQPSMGTGAGVKTLLAVAEQYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1W989</accession>
    <name>K1W989_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W989"/>
    <dbReference type="eggNOG" id="ENOG502TGT0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419774_0_0_1"/>
    <dbReference type="InParanoid" id="K1W989"/>
    <dbReference type="OMA" id="RERWATM"/>
    <dbReference type="OrthoDB" id="2564972at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="622" mass="65879" checksum="E3E4E1F248F964B4" modified="2012-11-28" version="1">MAAAQEAPAADATAAPAPAATAPTAASSSNTSTIQANTTVLSTLHNLLRAHVAAHPSPTLPYLHPYAPLPASAWKGKAKAELLSQPQQADALQAIRETMEGAKAVLAKRENDRLRLTRAMKEVVNHETALLPLGTTLSSLPPARRIPLSPKGTSDLLHALAKRVGLQCFAEDAGGQKTTLTLAGERFVVDVDIETDRDGKVTIHKLTATHITPGGETGKSEWIEGVMRKAVDQHTSLWNSKQGNDDKLRASGRTIECLLGELKMLDDLAVRDKTGIDYFAELETLTAAFGEKLKGTDEKVRIYPDPNQGIFPSFRLFDGGVNGNPTLRLRPTLQGESVSLPPSPESQVAPDGAAAAGSAMEVDQQHPTGICKGSWVIEAVDEYPEPCSSGKGIVVRRTWAIPGPEDGESKAWSASVKAEGAVEALGLAAMPIFPYNTDFVHPTESLKQHWSMGHPGPEGFVVGRIAVPGTWEAVGSVCSALRVQAVLNELINAAFPPSKLKDQAEQQADDAAGSAEGDDAEMVDISELEGARSDIPVSAMLFQQSMRVSMPLSEDADGALLLEIQATPEPPYVSVSWRVDDGVTVDDATRGRLDDAVTATKSMGPADLIGIVRDVAKALTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAV3</accession>
    <name>K1WAV3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAV3"/>
    <dbReference type="STRING" id="1220162.K1WAV3"/>
    <dbReference type="HOGENOM" id="CLU_783437_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAV3"/>
    <dbReference type="OMA" id="MMEPESY"/>
    <dbReference type="OrthoDB" id="3259746at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="354" mass="37001" checksum="23AE8D0A679FCD3E" modified="2012-11-28" version="1">MSTTGDLTWTGPTSVRQCERTLLTWSGGAGPFRLRVTSGSGTSRQLGPSSGISGRSYSWLVDYPAGTRLTISVVPSLARYYPTVSVSVLSGSDDCTLYGAVRPATIRSSTTRTSATPAITRITITPPRTIATSTVFATAFTGTSSDEESTTEEETLQTSTTRDSLSLSSSEYERLKQSDFTSSDRTASISGSHQPSGSSTGGSDGGTTGTPGDNVGGGGGGGGSAGGSSRDIGAIVGGVVGGILGLALIGALLYAWLHARRRRRNEPTNVLDLEAETTEAMMEPESYPVTPYTPTVTASSDHTGIPEESPLLVTKEAPAPPDQTDEYAIDAGPVREQRPPQYDPNWSREQPKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB95</accession>
    <name>K1WB95_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB95"/>
    <dbReference type="FunCoup" id="K1WB95">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WB95"/>
    <dbReference type="ESTHER" id="triac-k1wb95">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_1"/>
    <dbReference type="InParanoid" id="K1WB95"/>
    <dbReference type="OMA" id="QFCGDMY"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852826" description="Carboxylesterase type B domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="160"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="688" mass="73597" checksum="57A20AD18916DC7D" modified="2012-11-28" version="1">MLSLLPLATLLLHITSVTATPVPIPTDANEPCESCDWKGSMTYESERTSRFGVSSSYESSHAMPGTGGDSGAFQHDMPDAASPSGTGNTRVLPIPKGSSDASHAMPSSNSFASTDPTSTGSANASTPDLQGQDNASSSGNDSTGGVVNPFANANKTVTATMSVNGKDVTVHGVSAMGTDAYLGIPFAAPPVEDLRWKRPEPYAYGDEVNATTQPVGCMQPPPLGAWGGGAQAPYGQSEDCLTLSVLVPEGTKPDAKLPVMVWIYGGAFTQGSGSIYNSPLLLNYGAEAGQPFVLVTVNYRLGIFGFPIGQDAKTNKAGNLGLHDQIAGFRWVKEHIASFGGDPNRVTGFGESAGAISLSYLMFNETQDLFSAAILQSGAPSTTNTPPLGSWDTEYKTVLSNAGCQDWECLKQISAEKLLNVSNEANVSPALVFTPTQDGELITDRPFEIVKQGKFADIPFISGNVQNEGTLFLPPNITMDELRTYFKNTGDAAMSNETWQKILDAYPANGTYTSSVNVSTSSTQGQQVQVSSDFHRAATLYGDKSFDSRRRWMMQHARHQNTTYAFEFAGPYSAFPPVYGVGHGSDVFYLFGWVGIDPRNPKEQAALGYQMMAYWINFAYHHDPNAKPAISVGANGIAQAVQQTYWPPYGDDKASMLLKPGNVTRINDTFRPQMSVFDEEDVAAASNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD05</accession>
    <name>K1WD05_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein DGCR14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD05"/>
    <dbReference type="STRING" id="1220162.K1WD05"/>
    <dbReference type="eggNOG" id="KOG2627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024820_2_1_1"/>
    <dbReference type="InParanoid" id="K1WD05"/>
    <dbReference type="OMA" id="DAFQRNY"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="70324" checksum="B64EFEC64EBF585A" modified="2012-11-28" version="1">MPDDLRPRPGPPPRLIEGPSASSGQRSLYQQQVLDEDEYTETLSRIIGRDFFPDLPHLRATNAYLSSLARNDAEGLSSSIRQLARIAQDKDEGRSSWASDHERKEREKERAQEELRQQFDSTPRINLGQRGWDTPLDRGSTRRRARSVSPEAGPSRPQKARKQARDDLSLDAFQRNYTSEDNAAFSSILDSENQDRKRRNQLVWDFERVQEDRRIEGEVKRKAILDAAQSGWVVDGNGRRMIGGLAQGGRERADGEGGAWEERKLLTAPTEDSEAREGKGERGALVKRIEAGALVKSTQPTLNEKILPDSHPLSRALEMAGLPPTAITDKDGAIVPHRDLASGSGDGRGRGQSDRRALSDAEKAALSSQTREGGNVQQWPYKAMNGLMFPPDSYKAPYPPPPSKPSTAPSARKAPAPSVSYRNTRINDDEDDTGKAPSTSYASTWVDRAVKGKSFARRGSTSASVTDSGTDAGFDDEEDETGKEYDLVDEPDLEPEDMPLMTYGSLLATPKRVSADDTENDSFDGPSFRFPEEKKRDELGRKLGNKASKSISDRARMYAPSPSTPRTPSALKAAASRTTRPSSGSRGSMGPPSQRGNLTPAAQSLLQRTTGRTPMRFGKSDGGGGIFKSKVGGMGWSPSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD24</accession>
    <name>K1WD24_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA splicing factor PRP9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD24"/>
    <dbReference type="FunCoup" id="K1WD24">
        <property type="interactions" value="924"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WD24"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027160_1_0_1"/>
    <dbReference type="InParanoid" id="K1WD24"/>
    <dbReference type="OMA" id="LMYEDIP"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="489" mass="55536" checksum="AF95537764EC264B" modified="2012-11-28" version="1">MDSIFETQRATHEEIERYEQALADVLMQNPTAQRNITRRDRKAADILDRIGELRHNLVLMYEDIPGLRPTELSALTAPAKGEGDELAEFYSRFEKIKDFHRKNTNINARQLINEIEDMVNSDGLEKVQVEGEEEPIIVDPAHDVFEPEGKLAPVVRGVPRHAATRTSGADAGSAGEGSPRLPPTIYNYLVSFFDRALPLIDIHKKLKEDDAEFEKLWAAGEIEGWTEGKANGGVLNKEGIWCPYCQKRYSKQTVYDAHLKSDKHKKKEAAGKAVPESEASGAAESSTSKDKYKQPARYTFLVTSLLKVDPIPKILADSRVEVERRAALTAREREAELEEQEEAVPPPAEITSALEEEDEDDDERIYNPLKLPLGWDGKPIPYWLYKLHGLGVEFKCEICSDYVYMGRKAFDRHFQESRHAFGMRALGLPNTKHFHEITKIQDALALADKLKREGRQELIQMEKAEEFEDADGNVYDKKTYEDLKRQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WD96</accession>
    <name>K1WD96_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Import inner membrane translocase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WD96"/>
    <dbReference type="FunCoup" id="K1WD96">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WD96"/>
    <dbReference type="eggNOG" id="KOG1652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="InParanoid" id="K1WD96"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="181" mass="18709" checksum="48D5A20BF641C3F6" modified="2012-11-28" version="1">MSHADHTRDPCRRLSPPHAPHTAAPRSIQRKADSSPYVILNDFGGAFAMGAIGGGIWHGIKGARNSPKGERLAGSLSAIKARAPVLGGNFGVWGGLFSTFDCAVKGYRQKEDPWNAIISGFMTGGTLALRSGPKSAFGSAVGCGILLGVFEGVGVLMGRMFAQPVPAMQLPEQAPAAPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJJ1</accession>
    <name>K1WJJ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sphinganine C4-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJJ1"/>
    <dbReference type="FunCoup" id="K1WJJ1">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WJJ1"/>
    <dbReference type="eggNOG" id="KOG0874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043293_1_1_1"/>
    <dbReference type="InParanoid" id="K1WJJ1"/>
    <dbReference type="OMA" id="FFIFWDR"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="188"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="360" mass="41816" checksum="2A8B399F25ACED6B" modified="2012-11-28" version="1">MTMFDFPTGWIDRLPSFAASHNATLLNRITPQTFNPPWYYIARERIHPAISDTALSLAAPIIVYWIVSSVFHFLDVMEFPYFEKRRIHESAETKSRNRATLSQVLWAVIFQQIVQTITGFIVLESEKDVLRTEYYKDHMASLRWLAPRVADVTFALLGQSAGRRVLEAAGPRITEWFYWWGIPALQLFLGCCVIDTWQYWLHRIMHTYPVLYRHFHSHHHRLYVPFAFGALYNHPVEGLLLDTLGAGIAQFATFMTIRQATLLFTISSWKTVDDHCGYRLWWDPCQMFFANNADYHDIHHQTYGIKANFAQPFFTNWDYFLGTQMTREQAEKRHLPKGTIANGAPSTKVATANGESKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKM1</accession>
    <name>K1WKM1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-X-X-X-Q-X-W domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKM1"/>
    <dbReference type="STRING" id="1220162.K1WKM1"/>
    <dbReference type="eggNOG" id="ENOG502SS8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095794_3_1_1"/>
    <dbReference type="InParanoid" id="K1WKM1"/>
    <dbReference type="OMA" id="HPNTAFN"/>
    <dbReference type="OrthoDB" id="2593293at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852988" evidence="1">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="183" mass="20228" checksum="A6D5866A1F963557" modified="2012-11-28" version="1">MFTKFIPYLIFAGLVSAQCAPKGTTLHPNGDTSKCLDVRGAQFANGTPVQMLNWVLNRGNGKVQVAGTNYCLDAGSSMSFRGRCADSEAPGNGVKMKIWQCYDNLPAQQWFYTGDNRVALTNRGLCLDLTDGACSFPVYTDYKGKKTNANVMQTWECTPGNTNQIWTSDPTVQRRSLRYSQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM25</accession>
    <name>K1WM25_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM25"/>
    <dbReference type="STRING" id="1220162.K1WM25"/>
    <dbReference type="HOGENOM" id="CLU_444224_0_0_1"/>
    <dbReference type="InParanoid" id="K1WM25"/>
    <dbReference type="OMA" id="MPRTTHS"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="615" mass="65892" checksum="6AEAC980550A7D6B" modified="2012-11-28" version="1">MTAPPSRVSRTSSSGISESSQSAPSGDGWQVPDPGVTLGAVGGKSGRAEQATLGGHPHAEHELSSLYVSAERAAMNDIDKHLTRGKQRQGWAASLVNSALTIRTAYRLWSGWRSHEDDEEDHNDDDMHGGETSKSEDRLVQSDHSEPPPAYDTIADGVSTIASSPAPSVTMSRRRRKRRIKRPSIAELIIATRQQELAMLSPPTRPSSTRASSPETSLPSPTFLSLTPGQTPHRSNKRAAPEPIEEEGESEDEEMSLRLDDMTRRIQNLINDGQRALHSQPTLPPADPMPLPLLSVTPNSATSSTSEGRPSSDLFSPWMDDGRTSRRSSLSGLARNRTSLPATLTPPTKKFARDGPRHSTPVPTASANTHSAGSSPYTHTRIPSYHGSPLSKSPRPGKPMPAPTLYGSGTAPPLPWRRERVGSNKWIQRPPSPTLGELASTDQRDQRSVGSSFGGSFEFGSLSSSDASHPGTPVHGTWSGSSRPKLAAPGTPLEPPAYLRPASPASHTPQASQPAPHTPARSRIPRFDHGRSGSVSSRPGSAASTHTHQRTDSMSRTSRLTTPATPKAKGRARAGTDGASSLQPHRSYLPSPNIKPGTVAQRRLSFTKPLSHDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMN7</accession>
    <name>K1WMN7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMN7"/>
    <dbReference type="STRING" id="1220162.K1WMN7"/>
    <dbReference type="eggNOG" id="KOG0945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572650_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMN7"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="4">
        <location>
            <begin position="107"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="477" mass="51515" checksum="0F95C6001A409182" modified="2012-11-28" version="1">MVRLFSLKMPQEVPEETFDRLLHHLPERAQDRVRRFRHPDDAVRSLAARLLPTWYLREAGIVAPSEHPKFGVASRGKPYLLDPTAKVGFNTTHEGEYVLLAVGDGEVGVDVMDLPKDPQELEEGISFQDERLGLSTTSGIIKSKYLTTLWTMKEGYTKAIGTGISFGLERINVHVGDGQVSALEIDGKNARLDGWHWAVGSLDAGAYGWAVIWNGEDDQTVTPEPLDWNSKSHVERSAQLEKLADGDGGERDPSEEDVATDSDFSDRTVRASTVAPAGGGNSKQEETNRDGVAELIIERAAPNIDSQEPSNVPAVWAGTTRAASGKIETTEGLSPLPVTTSFDTSSQVCLESSSCPRSDPALSPVVESCSTGTPSSTRTHSRAKPSTGPLADRNFPLGIPSRPKTNTERVCVPFKSSLTSSSMGVDADSPSELVEDVEKMSGLEPTPLGPHSSAPSLRPAASTLLKAFKGRRSYFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMT6</accession>
    <name>K1WMT6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMT6"/>
    <dbReference type="STRING" id="1220162.K1WMT6"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759073_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMT6"/>
    <dbReference type="OMA" id="MALFRMR"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="365" mass="40122" checksum="437A877A9F4CADFB" modified="2012-11-28" version="1">MASLTEEERAIDPYRVLGIEVTATEQQVKKAYRKRSLKCHPDKNPTPEAAQEFHRISIALAILTDPGKRAFLDKKLEQTRAAEARRAEMDAKRKDLLRREEEAKRARTAAQDAIRQKAKEEEIREAGKRLLEERRAQAAAMRANTAHTSHPPAASAKHLAPPPISPEDLTILLVVSAPPPNAEELRKQLGTKYGKIADVFVSAPKEGKKKVRAVVEFAPGNWGGCWSCLRDAGGIKGAKAKWVGAEPAWVKWAAAQDGTNSLSPPTGDRTHAPSPPSHTGTPAAAPSTRFGSGAFGSAPDHFASVTMFPDIANLTASHRQRAQDERTAHAELASAQESATLLRMRQREKERQDMERRIRQEEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPA3</accession>
    <name>K1WPA3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOPA 4,5-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPA3"/>
    <dbReference type="eggNOG" id="ENOG502S93P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090062_0_1_1"/>
    <dbReference type="InParanoid" id="K1WPA3"/>
    <dbReference type="OMA" id="EGRSHHY"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21225" checksum="2DCD2D0B421F498A" modified="2012-11-28" version="1">MADRFAALKPYFPKLGSPQTSNPDKTELSYEPCPNGDGKSVYNPPREGRSHHYEALYKGEKEGSGEKPWWDFHVYHLPLNPNHVKYAQELYEAVRREFPELRVYRPLGPHPIPMFEVNVFNPLQLGALMSWFVQNRGPCSVLIHPNTGDDVKDHTTNGTWLGEKVPLDVDLLRAVDAMQAEKKEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQX1</accession>
    <name>K1WQX1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQX1"/>
    <dbReference type="HOGENOM" id="CLU_535491_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQX1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="509" mass="56736" checksum="B968319A8FB62E30" modified="2012-11-28" version="1">MLSPSTEVQYASPRKEEYSTIKLEPAPLSRHISENSSRESKPKFWRADRQPQASPMSANSASPTSPKPLRAPTPGAATPSTASSRMSRERQSSQTPDVEMEKLSLERKAFTEEPPSPPANAPSPDLGKAARPISQSASPPLRSPAQVLRQQPQHQNHANVSNSQSRKPKRMPQLITSLPSPRRHVSQPFSDKVYATSTQAHSAHPCHGGHSHLSPQPKSPVYGPRPASSFEYARAHGPPMHGPMSASVLSPVVRTSHRYSPYALPPTAPPTPVRTGFILTSPTTSVKGKHLVLVSSDMAEKMRRGGVIQFQSQDGKEYHARQSEVPGVAEQSALLSQLAEGASGKTFKYQAADEAMDVEEDTSPASVANARRGRDVREVRELRERRSPLLLSPPQVDPIVAATLAAEREYLRERERMLAVREREMAERAHILQYEREYERVYEERQRHFAAHPYYPRYAEREMRPVAHAQVGPWDSRIDHPRADRHPIVYATRPPRSITPREPPRSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WR37</accession>
    <name>K1WR37_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WR37"/>
    <dbReference type="STRING" id="1220162.K1WR37"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004823_3_0_1"/>
    <dbReference type="InParanoid" id="K1WR37"/>
    <dbReference type="OMA" id="ICTHMAT"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1196" mass="129025" checksum="D60599AF9FB918C6" modified="2012-11-28" version="1">MPSPPLSIIQSLSPRVAVLASDDVNDSCNANGCKGLEELLRPWEGGTERVSILSSTLQPTVHPSFPLRFVSYPSVYQQLSSPNPDIIVDLIGSCVGKHSPALLLSSRPLAPHETFNHPVGVMIAISTTTPDPMGTLTSLYGQAVGTGAQAAPWMDGVQVLKFFVVVHDVAKAGPSLVKAEELLANVKKAYGPHSTLLVINSRQQAGDVSTDVTTAEGPDSQGDAGALSQIYANALSSLTLSPMGAAAQMAEDGPPKTYASLLTSEDIQRLMALVRELVVQSLVPWMEARIREWNEAYQSSRRGLTGRLFGAGRKLFSSRPSSPSTTTGPAGYNAIKGYYPVNSPDGLSRRLADFAFMLRDYRYAAGVYDSLRRDYVQDKAWRYAAAANEMVGLSQLLSNAFFLPNTPPGSIVPFTTLQHTEISTCLENAVISYYQHGPPGHIQLDALRATVLYYEAWKAIQEWRGVGSALVKGAGEADEVPCAVLVEEAAAADVKGGKSKRGSRRQSLHLVMAAKKYEKAGYKAFSRRCLEQAASLMRGAPWKAALDNLEYALGRQAYTLGESAVAVEHFLRLLKREDTSSPGQSMVLEDMALAYEHLQHHPDQLEAAKGKLKLPTPIFDISKTKILLPEASSEHSTEGWELLEKRALANWDRKGKKPLSILPDPRKIAACVGETLYVELIASNPLNAPIVLENLTVGIEPAAAVEVQTIDEVALAPYETGAIRLAITPKAEGPFTVANATFTFHRFLPCVESLERKGKRLFATKQQRLKPMYAKDTSLTVHAEATRPRLEIELTGVPGSMFEGELVDAEITLRNKGTLGVENVELITNHYGAIVSPGKSVTVPVVFTAVAPGALDVKALAIFSAAGTDVLGCSRVSHAAEVRRALAINTEVAPARKGYFLAVTVTNHADVPLEVTGLSAVSEYWHLTSPADVSSEPLLPQQTQRLVLSVQAGGANVDLTQARLVSNLSHVLAGRPEAIESIEPVSVKLQVPTAEYLRARRAWRLRFATEHFPTLPRELVPRVLPLLDPLELDLVASWAAENRYGFACAHGIRPAPAFSLVESLRGGESTAKRTMYEETGRQMRALNEAVLEGVFADEADPLLVRTRVPSAKQGRVTHDFTKGGPVYTGTLSHRGTIPAGGRASVKTHAWVCEPGRVPLGGWEVIRETGDAETDGEWVPRMSWIGAGGGSVEVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRI1</accession>
    <name>K1WRI1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRI1"/>
    <dbReference type="FunCoup" id="K1WRI1">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WRI1"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068770_2_0_1"/>
    <dbReference type="InParanoid" id="K1WRI1"/>
    <dbReference type="OMA" id="VKFYRKE"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="295" mass="31982" checksum="66D9BC9D18A73886" modified="2012-11-28" version="1">MPNPQLSAVPVGTSVKRKAAPRDDEGDESDGSDVSMINVDFDFYNLNPDVDQIAIKRLLRQTLSHDDHLIDVHQLADLILAEGTRLKAGSTIKTDGEESDPWGMLAAVDIRKCQDNPALKPLIDYYLSTAPPAAIKSALTDGSSKPALLFSMRMLNLPLPLIPPLYKMLGEELSSAGFTHYILWGRGYKLEGAEEATGLEFDQSATNKKKKGGQAPGGLAAGSFTYHPEEEMIDSRAEAVHTYSLKTAPPRDDESFGVEQFGRLLLVSSDKLAQAVGAMEEACKPSFRVPNASAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRP2</accession>
    <name>K1WRP2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Organic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000243">
        <property type="protein sequence ID" value="EKD03644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRP2"/>
    <dbReference type="FunCoup" id="K1WRP2">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="InParanoid" id="K1WRP2"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="153"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="246"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="339" mass="36980" checksum="657269D8B306C904" modified="2012-11-28" version="1">MSTKTAAEGAVVPHKPAPLPFAYTFAAGAIAGVTELLVKIREPSAPVTHLNTKTPPEAVHRLVNSGRTLRRVRSNNQMLYPLDVLKTRQQLDSSKNPPGMVQTFKNIVKQEGVGRLYRGIASPLLMEAPKRAVKFAANGWWGNVFTDGGKKKTTQPIAMLTGMAAGATESFLVTPFELVKIRMQDKNSTYKGPMDVVKKVIAQKGPLGIYQGMEPTFWRHVWWNGGYFGSIFQVKALLPKAEGKEAEMINNLIAGTIGGFVGTVLNTPFDVVKSRLQLHATGEWTYPALFRIAREEGIGALYKGFAPKVLRLAPGGGVLLLVVEALSTVFRKQLGPPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRX8</accession>
    <name>K1WRX8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRX8"/>
    <dbReference type="STRING" id="1220162.K1WRX8"/>
    <dbReference type="eggNOG" id="KOG2172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003783_0_1_1"/>
    <dbReference type="InParanoid" id="K1WRX8"/>
    <dbReference type="OMA" id="NEHESAV"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="77870" checksum="C70B2A031EE94747" modified="2012-11-28" version="1">MARKNSRASAVFSASTEGKKKSKPKGKGKVRDNVDDAYTFEQELPKRHRTAESKFALTREEKVGGARRIDDEDEDDMNARIRKVAMMIAGDDKADVLDSDDEDVESDDAWDSEGSDEERWGDAFRKLEKGKGKKGKGKEEVLKINLDETDDEESDPEVERSPKTAFKSAFPEEEGEDDEDEDDEEDDEGDDEDDDDDEEEDEDDEEEDEEMFEDPELPSDLSDDSDEDLDGLDAFVDNLAAADKKSKAQPDAEKKRRVLPVAKGPGLADGENKVDLSSLIASAPGLAGASSLLPSKKENKSTSVLKGGVLAAPLPTRVQERLDREAAYEQTKQEGQKWSTLMKRVKEAEHLSFPLQATERGGVKSSGEVVATFKPENEHESAVQALLAKANLTDSGVTAAEDAALRGQDLSPEEIAARRAELRHQRELMFRAEAKAKRVAKIKSKTFRKLKRKREAKAAGDGPSLEDLERLDPEAAAEERERLDRERALERATQRHSARNRWATNAAPTDEAMEARQDMFDMRDRLRAKVHAKDGSESESSESEDDSDEEAIKTRAFDQLSKLDSKLPEVPQKKGLMQMAFMKKAEEREMKKVAEEEANLRRDLEMFGDDSDSGSDSDEAEVLKLGEGRMVFGRAAGDDKPAKAKPAAPAANGSATKARSRSPSPAVGVFGDVNPWLDGTNSGPSRKRNKLTATAGPHADGFHEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSH9</accession>
    <name>K1WSH9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSH9"/>
    <dbReference type="FunCoup" id="K1WSH9">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSH9"/>
    <dbReference type="eggNOG" id="KOG0448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSH9"/>
    <dbReference type="OMA" id="RCERMIL"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="12">
        <location>
            <begin position="212"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="870" mass="95282" checksum="C80A3F8A4E24D4D6" modified="2012-11-28" version="1">MQPYRAQAADSPFVEKESHIGHHSALSQSIIAGNAALRDYEAKQNQLSTAIDSTTHLVADLKNFNGDSWQIRYPHFSSAPPSSGPRARPGIGRRTMTFVDEPQASSEVIVTARPNVRQQLTRSVSYISSGSNLTDSEESVDSPLTELSEEPLSNVAEPNDDFSILSLDLNLGATRHAQSLITRLERSSISALLDNRLSAALRHLSLLHARVNDAHSRVLVTGDLNAGKSTLVNALLRRAEVMPTDQQPLTTRFVEIASAEENGGKEEVHILDQESYDVNNPSTYSVAAISELESLATDPDVDASAPPLRVYLKNRESDIPSILHNGTVDISLIDAPGLNRDSIKTTANFARQEEIDVVVFVVSAANHFTLSAKEFIWQAGQEKAHLFIVVNRFDQIKDKERCRKAVMDQLRQLSPETYADADDLVHFVDSASAAFGFSEDDEGAEELDETFSQLEQSLRSFVLVNRAKSKLGPAQNYITHLLADVELLGSANTLVAVKERDAALQVVERVKPELDQMRKGKDDLEDSLVREEESATSHAITAAESSLRQALDRVGRGEVPGDVEMPRYPGLLGAWDYAFEVRRALLSSLDKAVRDAEDASRMLTTNAVKEVNVIGDKHLPIDVERSKRVFNANAMFFNHGKARRSSGMTNVGLSLANNAILKEVSVSDIFDLQYLLFLGDDVPVDKKSSTLKSLIPASVPTEMSGLGAASVAIGAFSMAGGKTMAIRTIFESAIHLSELASSPVVRKWAGPALGVLVIGAVAYVVYELPRSIPRNVGRHIRASLLAGAADEGEETPFHQAEAQRVGREVRKVMRLAAWDLRERFRGALESRTEIVRENEEAARRACGAIEWFAQVDSRVEGIRSQLGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU53</accession>
    <name>K1WU53_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU53"/>
    <dbReference type="FunCoup" id="K1WU53">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WU53"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012507_1_0_1"/>
    <dbReference type="InParanoid" id="K1WU53"/>
    <dbReference type="OMA" id="FVICRSH"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000186">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="W2" evidence="11">
        <location>
            <begin position="625"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="804" mass="89176" checksum="3FF083E3900F91F9" modified="2012-11-28" version="1">MFALFWTSEPKLELDRSSIPLTESNAAQEAGPEGRAEAGEYIPLTGVNYRCPAVYPPYGLADIQRGDNVDEAPLQAVILADSFNRRFEVLCLDQPRILLPLCSVPLLMWTLESLSHSKVKQVFIFCGVHADKIRAFVEESPFQHLLDIQCLSSTTARTAGDALRELDAMSLLNPENPFILVHNPIVSNYDISHMVEAHKKRREVDKNVIMTMGVARGGRQHPESPVMLVHPKSSRLLHYSLNPLSPRKQRVDFPANLFLDPWPASIDEYEIWSGTSAASHRGGYRDVGIDVCEADVPALCTENFDYHDLRRHFVNGVLTSELLGKNINVHLVGEEKAEEKADAAGKGGRYVERVRDTRTYGEITQDILRRWVYPLVPDVNIPGGSNYELRRGNVYVSRDNVMLARTTDLDGPVLIGANNTLSPNVTVSKSTLGAKCFVGPNTTIESSHIFTNVRIGADCKLEECMIGSNVTLGDGVVVGKGTLIGNDVVIGNGVQIPEFSRIGRAIYRPEDWDSEDEDNEEHEEAMRNHSLTVLGPDSKGFLWPTEEEEELSDSDDEDEDPYEHPRNKRWLQLGRRLSDVSVNTEGSLSTLSIASSTPDESLIDVDGDDFDSDIEMEVAGLNLNGGPSQAFYNEARSSLARAYEEGHSVPNASLELKTLVMGYNSGIDPAREEVVNFLMAKIPTEGGAAKILQTATALWERWGKLASGLARDSSDIALDAQTFAVRNPAYIPWFGLILRALYDSDIVDEEGLIEWRSLSAARGEGAKENEREKYREAFAKGKQYVDLLEQMDSDSDEEEDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WV28</accession>
    <name>K1WV28_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000205">
        <property type="protein sequence ID" value="EKD04664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WV28"/>
    <dbReference type="FunCoup" id="K1WV28">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WV28"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_3_1_1"/>
    <dbReference type="InParanoid" id="K1WV28"/>
    <dbReference type="OMA" id="PYNYQYE"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="198"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="644" mass="71301" checksum="DED0CD03B6C1EA53" modified="2012-11-28" version="1">MAQPPTMHSGMGHRTSETSLNSYEQSSSNHGYNRAYGPSAGAGIGGASAGTASSRGGYAQGTTSSYSSTPRYASPANVSPQQTGSPRFSPAETMPLREGVRGGSGPLQGIDESDLDDQLHTFTAADRKDLSTPFDITSWRGWANGLTLFVLMAGFIVLFAGYPIIDWAYNNENSSGGNTPGFNLGGVNASGQTPQMPADFPSMIDPDTPEDVKKRTGFDGEEWTLVFSDEFNKEGRTFYPGDDPFFTAVDIHYWPTNDFEWYDPGQVTTKDGHLVLTIEQIPTNNLMFRSGMIQSWNQLCFSHNGYYEARVSLPGHNDIGGFWPGVWTMGNLGRPGYGGTTEGLWPYSYDSCDVGILANQTYVNGTGPEATLTTGQVDDRQGYKGTLSYLPGQKLSKCNCDWDDHPGPKGVGRGSVEIDMIEAQIDLDVGHGEVSQSAQFAPFDDHYQFYNKSGYKIFNEDVTRPNTYLGGVFQQCVSCLSYTHDSIYHDNQVENRPTADGSSEPFGVFGFEYVADYENRKDGYVTWVNMGKQSWWMNYDTVQPNKKVGVGQRLIAEEPMALIFNLGMSNNFQNVDFRNMNFPNYMRIDYIRVWQKESGLVGCDPEDRPTAAYIEKYKDVYNNPNFTTWAQAGQKWPKNKLTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0W8</accession>
    <name>K1V0W8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000407">
        <property type="protein sequence ID" value="EKC97564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0W8"/>
    <dbReference type="HOGENOM" id="CLU_1125208_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0W8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="247" mass="28694" checksum="BC639EFF64A04FC8" modified="2012-11-28" version="1">MSLQLGLLSSEPSFEAFRCWFSQHAAPKLPTSYDLLLLLSIFHFVQWAYVRPLDPESQRASKHLYATRHTTLLANLLFFHQTAVKTAGYLLLWVFRVDPVAGAPLWTYFSRHGSSHLLPFYWWISVPLICTLAFFSMLGLLVRYPVDGFDVDLNRLSGMWALRLQHEYGVHVPRRRRGSFGCEKYYAEDDESDSSSLYDRAEEANPEDKVHLNMSTVLRLRREGVDLEKWRYGVRQATMADSRPSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V198</accession>
    <name>K1V198_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V198"/>
    <dbReference type="HOGENOM" id="CLU_1628231_0_0_1"/>
    <dbReference type="InParanoid" id="K1V198"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="164" mass="17992" checksum="7BCC72CECF40D03D" modified="2012-11-28" version="1">MPNAWSQFATSAIPAQEEEIAQEPACADPADTTPLYLTMEAMSIGETPEGEPRYLVKAKVCIPEGTQLAAPRISAEPSQEEEFIDIAFLFRLASDGKLELHLHPDSVLTQEQADNLDENLIAVKWEPREEIKMFVTVPDLTVLGFAGPGWPTIDKSRLATAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1W4</accession>
    <name>K1V1W4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1W4"/>
    <dbReference type="HOGENOM" id="CLU_508240_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1W4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="536" mass="58132" checksum="7289EF6916B9E921" modified="2012-11-28" version="1">MGDATLGERGAMLANELSHPPFTFKYESELETWFMKQFNALMDHIMAMWERPGQSICPPISWQQQNMEYRHYSGDLRQAMMDISIRVEDEVLTSGELKHGLRLTQSHFDALDNLRKRDVALWVRPYNPGVDSKTHMGTDGKRLPATKLQTNFYHCGLVTPTQKSAVVGERGVQVLVCRWPRSTSGRLPFELRDGDVSNARGPRLSPLETAALQLITETPCYGWLSRSERGSTWNGDRWIATVLDPHGTIDLKPGAKPKPPQIFWGQSLGLKQHGPQMSSSNVPDSGTASGPTMSGKRHMKSTISSRRKATTSRLHEDADLDAVTEEMRIMAVEQRMESKASAVLDIFTQPSPDSEAMQSSPVDEPPSFLAQLLGDAYLAHKTNSRSVESWPSATQPVKPTPGPARPPGDPSLRTSTGTPSRAPSRRTVGASTASSTASSTATSTATSTASRKMVTKASSKAASVVGTRTAPVKPERPARGAKSQDKGKERVGDVNGNGRAPSTAPPRPSPGARARARSERTGQTVDTKGGAVPPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2S5</accession>
    <name>K1V2S5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Las1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2S5"/>
    <dbReference type="STRING" id="1220162.K1V2S5"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031483_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2S5"/>
    <dbReference type="OMA" id="HRCTHED"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45531" checksum="02E54731F9E10ABB" modified="2012-11-28" version="1">MRVPRRVPWASKAELAELYDLLFAPGANDASRQAALSRAASATRMSYAMAVVRFVNGMVDPLQTGPYARPISHLAASLGIPSSLVALRHRATHEDLPPLPMLRRAVEQALDYLHRQSFLPLLASSSAAGWDRRAKLEGLVAEWKKIVKARVRTHDVTNESESGLALRRLKRAIDAEDADDVLDAVVRTGLVPVARKKRSHRRANRPPKEGLAIWRPLLAHLDATAPVSAALTECLVGALLDTAPRLNPPPAAPDAAEDHRKEMASYRWTLGTWLLWLWAGEGGLTVPEEERTGVLRRIARELVHGDDVLRRVYAELAEDTDAPALDELDELLLHESDAESESDEEELEGLEIDDGAEKPDQAPRDVDAQLAAMEANLAALNEKPKHTLQTSADGSSVPGWEHVAEWKAAPIGVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2U5</accession>
    <name>K1V2U5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2U5"/>
    <dbReference type="FunCoup" id="K1V2U5">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2U5"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_8_1_1"/>
    <dbReference type="InParanoid" id="K1V2U5"/>
    <dbReference type="OMA" id="QNGSPMA"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="369" mass="41266" checksum="2CEE588C34D4F48D" modified="2012-11-28" version="1">MQGLVAAGVPALTYDPVKQRYIDVNGREYLPDELEQDDDELEFDSSSQGSSDETSTVTWITWFTSLPGHDYFCEVHEDFIEDDFNLTGLQSLVPFWKEALEMVLDVEPEEDSSKIPDVSIVESSAELLYGLVHQRFILTKPGLVMMVEKYEAGHFGICPRVFCHATHVLPCGRSDMPGIDTVKLYCPNCGDIYTPPSSKYQQVDGAFFGTSFAPLFFQTYPELLSAPFAPASPGSSAPSRDRHMSPDPSRVGGETLTNPNPHGGQRPALGKVYVPRIYGFKVSERARSGPRMRWLRERPERYDELEMVDHRGRWKDGSAPQDVEVGGKPAKTRNGRLFDDDDDEDDDEEEEEEEEDAPAGGAPVATTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V421</accession>
    <name>K1V421_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V421"/>
    <dbReference type="HOGENOM" id="CLU_947277_0_0_1"/>
    <dbReference type="InParanoid" id="K1V421"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="294" mass="31309" checksum="2AA0C4D60A576EC4" modified="2012-11-28" version="1">MVRTKAHANSALSGAKKTHKGYNYVQKTMHGLATLCAIGSLIASAICAHKAHKYRGDDDDDDDDGGHYKMARNVSIAAAVWSGLTILQQGGQGGDQWKHATKVAKLRKLRRNNNEDQRGLNAGGAADYGYAENRRRQLIHLAIQAAVIIFGIVVLAIWANPLMKRTYRNASFISSLKAWGILGWIALGLLILGLLIALLMLFTKKRHTVDNAGYDNAAYGDTAYTGTTATTGNVTHTGPMAHSGNMAHTGNAAYTGNTAYTGSTVPIGNTANVGNQAPVANQATYGTQPQMTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1V550</accession>
    <name>K1V550_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V550"/>
    <dbReference type="eggNOG" id="ENOG502S7YB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794980_0_0_1"/>
    <dbReference type="InParanoid" id="K1V550"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="entry name" value="SO1590-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43800">
        <property type="entry name" value="PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43800:SF1">
        <property type="entry name" value="PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SO1590-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="287" mass="30390" checksum="D93BBFA6CFA65335" modified="2012-11-28" version="1">MVQLRSAALSDHPSILMVWRRSVEATHDFLTAADVDRIAQAVPTYLDHVRLTVAIDDDRIVGFIGSAVPDASASAPTTTSDLPTDCERMVSIEMLFVDPSVFGRGIGTQLLEDAAKGNSTVLVDVNEQNPAALGFYKSRGFAVVGRSERDTQGDPFPLLHLKRVTSPATPVPGSHIVGSFDLSFTGEMQGKAHCTLVMTAYGKQLANGHKPNDFAGQAYFTGKLGGAEGSIAINQVGIFDGKRMVSTWTFLPETGTGQLEGLTGTTELEGSDPTPGAFEGAVEATFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9H1</accession>
    <name>K1V9H1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_08308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9H1"/>
    <dbReference type="FunCoup" id="K1V9H1">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9H1"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="InParanoid" id="K1V9H1"/>
    <dbReference type="OMA" id="NIYESFF"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851697" evidence="7">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="39412" checksum="030A59053C7B14FE" modified="2012-11-28" version="1">MWGRVVLLLFLLVGVLAADYYSVLGLDRSASEGDIKKAYRKYHPDLNPEKEAHDKFIELSRAYEVLSDDELRRIYNRGGEPALKRHEEQKNAPDPFAQFFGGGRQEPPRTPTVFANLKVPLAQMYNGHTAEFNMPRKIVCPHCAGGGADSPKHIAKCGTCDGQGVVVQKHQVFPGMFTNVQMHCPHCAGKGQKITKLCHQCNGDRVVQRDHTLAVHIPAGAPEGYEVVFTGEADESPDMDPGDVIVRVRSDPKSGQGWTRKEGGLIGRVTLSVAEALLGFERNVTTLDDRIITISRDGTTQPNEVEVIEGEGMPSFHDVPQGDMFIEYSVVMPAAVSDATRRKLVDAFGPHASLRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAP1</accession>
    <name>K1VAP1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAP1"/>
    <dbReference type="HOGENOM" id="CLU_2456358_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAP1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="89" mass="9856" checksum="F4551A631E136C7E" modified="2012-11-28" version="1">MAKYLTAPVARKAGAHNHAVRRATRTRACSPRASVRAYRRCSSNSSAKQLAIGRVDPRPTRIVVSDDSDSDDDEEDHVVYYSDFDGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAT3</accession>
    <name>K1VAT3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAT3"/>
    <dbReference type="STRING" id="1220162.K1VAT3"/>
    <dbReference type="eggNOG" id="ENOG502SA5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131612_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAT3"/>
    <dbReference type="OrthoDB" id="3597994at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21796" checksum="0EF741D3561A8839" modified="2012-11-28" version="1">MAETHAPPPNVPGGTAGAGNTKLAAVKTNAAYLLHGKNAAVQPKSVATRGLLTTCRYVIKYMIRRMFRVAKYAAIGATVAVVGTTVLGALGTSMAWFAAPSLGMGIGTGIIWGLVKRRKGGMGRHGRDGESDRERATSGTRSSADEQFGWRHRPDRLRVSWWESMKERADAGSDPAKDEAGDAAAAAETPVRKRAGRDDIWMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCD9</accession>
    <name>K1VCD9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCD9"/>
    <dbReference type="HOGENOM" id="CLU_1344092_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCD9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="204" mass="22657" checksum="5D29C8D4182094C4" modified="2012-11-28" version="1">MPPSRPQAAMRIHRPHRRRQDPAIPPAPPKREDVERSRLLAQLEREKRRVASLDADFRSIGRRQEEIRRRARPTLPLSWLPPAPATHEACGHTADGVNGTTTNGDPENVVNGANGSNTEQRAPVRSNSTAIRSNSITRRDQDLDAHTQLALARLDETAAQRRIERAERLIKIQTVEGLLARLVPAGGEEGYDEGSERSESVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCF9</accession>
    <name>K1VCF9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCF9"/>
    <dbReference type="HOGENOM" id="CLU_1687975_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCF9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="156" mass="16671" checksum="E6120E5AF5B33968" modified="2012-11-28" version="1">MGGPGLAVHDQRTFGTGAQNLVGRGAISGRWAHGSASSGRLFAQGVQHARERRCSSSGTECLTGDIPAAAALKGPRHPAKRAKSLPRPRHAPPENAGGSFTEMSLRYMPWQQGKRHVGHESVRDAYEQTPDKNGTNERSQSLRTSAGNTDIIALIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD80</accession>
    <name>K1VD80_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD80"/>
    <dbReference type="STRING" id="1220162.K1VD80"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="InParanoid" id="K1VD80"/>
    <dbReference type="OMA" id="REAMTAC"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="384"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="660"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="717" mass="79073" checksum="5EEE45382AFB4ED4" modified="2012-11-28" version="1">MLPRLFRSTRIAARPAAAVRTTIVVPRLPAALRAYSALPKLKDEEDAFVGTPAGQEAAQSKIAAAAANVGRAQLSESQLAADDFFTPEVAAEAEKVDTRPAVQPAAGNPEDDPRKFASLKNKIDPDLLKALTGRPFRLTDMTAVQERVLNKLPELATTDREDLLVKAKTGTGKTIAFLSPAICARDAQLDKAVEATNPRDKAVAGLARREERTKQLGALIISPTRELAQQIADEAEKLQTHNKDRQVQLLVGGRGRFEQLKRWRSIRNGRKDIVVATPGRLRDLLAEPEVRDVVATTDILVLDEADTLLDMGFSQDLQFIVDHLPPKTERQTFLFSATVSREVRDIARDFLKDNHDFIDCVPKNESNVHAHIPQHVSVVEPEDQLKHVAHLLLQDQLEHGPKSKVIVFLNTTKQTMLFSTLLKQISQAHAFPRGFKVHEIHSRLTQVGRERSADRFRNEKYPSVLVTSDVSARGVDYPGVTRVIQVGVPSSEDQYVHRVGRTGRGGSKGGRGDLVLLPFEAGFTNALERLKVPFTTLTYTEQAEAVVAGDKMGEEAGEKLLSKVDAATQALPELLDERAIGEVYFSLMGFYASKAGVIGKTNAERIYEGLNDWTTKAMGLPQPPYLSHEMKARFGLGGKKAESRGNRGGSRGGSRGSFGMREDAGRGGRDRGDRNDRFGDRGDRNSRFGDRGDRGPRREFGGDRDDRGPRRSRSPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDF6</accession>
    <name>K1VDF6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain containing 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDF6"/>
    <dbReference type="STRING" id="1220162.K1VDF6"/>
    <dbReference type="eggNOG" id="KOG1552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_3_2_1"/>
    <dbReference type="InParanoid" id="K1VDF6"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="321" mass="35315" checksum="DA1A903B31A2F79E" modified="2012-11-28" version="1">MASAQALLRKAHYIPLLALGLYSIVMYCLTVPWIQRDCTDLLVRYPAVWHLTAAFKTRNVYLDTPDGERIGVWHVLEQEPFPPRGPLSEVQFDEAMAKRPTIIYYHGNAATRAASPRIRGYIEMSSRLDWGYADSTGVPSQAGLITDARTAWDWVAERAGKNGKAEDNIVVVGHSLGTGVTSALAGQLADEGELRMESGELTTRHLPARADTHRALHVYFGAARFRTRSPTLILHSLIDEIIPPSHSQRMFRQLVAPNATAEASDAAFSKVDIVEYPGWGVVKTATRDGLPMIYLEADSGGHNKIGWAEGTLDLIAKIADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEZ6</accession>
    <name>K1VEZ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEZ6"/>
    <dbReference type="HOGENOM" id="CLU_1295222_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEZ6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="213" mass="23247" checksum="9FA35BBA7E5BFD67" modified="2012-11-28" version="1">MWWGGGQGRLARSRWGGVGGVSAESERNEYDKRRDRSPDSWLEIKRELGGFGVSRKLKHNASAARVHRRDETVRLERKRGNGGSDSDEDGRTERRRTRALIRAGGVGGSGLAARTRAGARHGESAVLRRCDTSASSRISTRSAGSDCSASPRRAHPARRRRARGEDKRPLIARRDVQARPRAGRDGRESAGGDDPGPGAGGEFLQISMISLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFR1</accession>
    <name>K1VFR1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFR1"/>
    <dbReference type="HOGENOM" id="CLU_092901_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFR1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852127" evidence="2">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="186" mass="21879" checksum="479F104CB5CB33BE" modified="2012-11-28" version="1">MRITILLATGLAGFAAATPLLPRYVLEDMDTLAPEEENPNEEGDHHEEGDHSEEWEPEGKDDGEWKPEDNHEEGQAQEEWKPDNADNAEEEWKPEENQKKWHPEEKQEEWKPEWNQEEWKPENGQNPEEQQPHEDQKSEENDGEGSDSSEEYVSAPGERPFHWKPESLDTMHKLEDWIKAERYGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG07</accession>
    <name>K1VG07_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG07"/>
    <dbReference type="STRING" id="1220162.K1VG07"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="K1VG07"/>
    <dbReference type="OMA" id="LNFMIYN"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853751" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="871" mass="91917" checksum="605A9DFCC4EE0525" modified="2012-11-28" version="1">MRAFALSAAAATALLAPAAQAMAAYEPEFQQLVSRATTQDAMAAADKAFDFIVVGGGLAGLTVASRLTEWNNVTVLVLEAGGTGDESQNIQDRVDMPGKSYINSLTGTEYDWKYKTVQQPKSGNQQKSWPRGKILGGSGAVNGLFWCRGDKDEYDAWASLNPGTNETWDWNEVNKYIMKAENFMEPPTDMVNQMSLKYDAGAHGSGGPISVGYSQYIYPVTSNWIPSWTELGFDAKDLAGGSTRGVMLTPSTLNRDTQSRCDSKVGYLDPHEDRGNLVVLTGQQVTKIVFNGTNDAQGNPIASGVTFSAGPGQKVFSAQAKKEVILSGGTVGSAQILQLSGVGPANVLQGAGVPVVKDLPVGYNLQDHVSNTMYFNTQPIDTWYELANNKGLQDEEAQKWKNSAQGLWTYVNEAVGYISGADLYGTGSAAASNVDVDAMLTTLDGDIGLPASVKNGIRAQLELQKQWLSSTVGQFEIILHLWGQTANNIGIQVALQHPFSRGTLFITSDSAWDSPSINPNYFGIDKDAEMGARAQEWVRKLVATPTWKKIITAEVGRDGSKGPTDDQGWFAYNGKTEYHPLGSCSMLPEDQGGVVDTNLKVHGISNVRVIDASIMPIHVSAHLMASTYGIAEKGADIIKAKYVYVPPPPSPSTSASSGASSTGLSQETQAGPATTAEIEDATDSAIKSAAADGNAKASSGQMTMGTKIGIGVGVGCGVLALLAAILFVVGAARKNKRRAASEKGWYAGPSADGGAWDAGAAYSEQEGYPMAPPRGRPFSSAGASVSTMATADLYHPTPGSPSGHGDGYDAYSMGDYSRGGAQSPYRDFVDEQPSYPTPGTPGSPGSFTGQGSPMPSPPQWGAQTYTPVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG53</accession>
    <name>K1VG53_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG53"/>
    <dbReference type="HOGENOM" id="CLU_1147877_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG53"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26766" checksum="FB988FC46E66C87E" modified="2012-11-28" version="1">MSKLKQDSASVPISRDVTLIPAVGGARIMVNRTQLYAASAGEANWTSPNTIQFTDPAFESGEVLRYIASLVSNGEIGPEGDVFDDNKQVVPAVVKFLRRWDCPRFLAVICQRTAEAHAGAEIRDSQAFVIGALAEDVRLCQQAVAHRHEPLEVSHIPIEFWPHIKPEYLFALATIKAGKERIRCDELCDARTWRALVELGADGLRYFAESCEMGKAPFPLSPCVCKKEKKKSIVKKELGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGB2</accession>
    <name>K1VGB2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger Mcm10/DnaG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGB2"/>
    <dbReference type="STRING" id="1220162.K1VGB2"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015393_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGB2"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="3">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="892" mass="97550" checksum="1739F44B7578AE6B" modified="2012-11-28" version="1">MADLDTADLDAQIARLQEERAKRMAKAEAEQRRAEASAAKVLIADKEKGRIPLPEKPRQPVFVPRPTAPKTSHVDLQQAPKKSTVLERLAARKAMSDKLPSLPSVERSTSFKDRVASREGSRSATPVGAPLKSINPGGDDLEIVRTGKERAEDLTLDHELELGPREFGKDPEGEEVWRALEPNSGIRLSKRVLPHEDVQDLIRGRFFLRPPQVYSIARLSRDGATYDIPVEGDWVTIAVVAERGDIRVSGTRNVKSDDEDDDDDGSDGDGRQPQHQKGKKQGKQGKENKKRKPRKYINLKLVALPPRNKTLGSNTISGDAHLQLLLFESDSIVNGKDDEGNETRSYRGGSGGAYEKWCNLGVGSVIALLNPRVLRPLKAGGTPHPLTLPLALNPASADCISYIGQAMDMGRCTANQRDGSRCRTWIDLRLGQVCEYHIHAAVKRGRSGRGALAGATTAFELTDRPMMGRRGGFGNANMDKYDPSRKTGLLPRDGARAAPRGAENGGGGATYIVGSGVARIGRTDGALAPIGDPDLANKLGRNTAMKRKRKMEVAEAEAALSRMFEKNGDGTSAGAKYLQALGKAPTTEKEPGWEEKTKRVYSAQAIKNIGFDPTGRRNENAEKRRPIRATLNFVQATSTISAFLATLHYSTFTSFHHLVTLDIPTSRATIIRYRTGPHHYPRARQTGSPAHLLPTPHPSIMTTLPPSLRPTAVASLTPPPVLVPPINFALVAPGVYRSGHPNRRNFGFLQRLGLKTVLYVARSDEYRPDGADFVSQHNLNLHHIDLSDDEELFTPSGKKRMYEALQIVLDTRNYPILVHDDTGKAAVTLLCALVRCYQNWALTAVFREGDMFAGAGGSDDSGLGNAGKEFIATFDPRSVPLDPEYLPDWAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGC1</accession>
    <name>K1VGC1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyl-CoA thiolesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGC1"/>
    <dbReference type="STRING" id="1220162.K1VGC1"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_3_0_1"/>
    <dbReference type="InParanoid" id="K1VGC1"/>
    <dbReference type="OMA" id="CPWAGHE"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="189"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="35862" checksum="4528F96C98124B9F" modified="2012-11-28" version="1">MPPQGILMYDSLKVVPTGARLLGLECFSAVNLWTPPGNRGVFGGQIIAQALMAANQTIDGMDLHSTHCYFLLPCDSRKSVTYAVERLRDGKSYSTRLVHAIQDSETIFTLTCSFSMPRGNSGTKRFQREFPEDITPFRDAYDNRWNDHITVMSDFGVKIADTEENRQKFFASKERPLTAFGARPQEGKYFNQRAVWLQPHLGDSRKLTPNEIRAMIGYMTDTQAIATAGRTIGLSADSNPKLGMVATIDHTIHYYPFPEGYDGTQPLLHVLEAHIVDLQVGRGYITGRVYTEDGVLIATTSQEGVVRAQAPGVKPRRETAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHI9</accession>
    <name>K1VHI9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHI9"/>
    <dbReference type="HOGENOM" id="CLU_069202_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHI9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="228" mass="25502" checksum="5A46FEBA1C0C37DC" modified="2012-11-28" version="1">MVTDTSSRAAEGMVWNLKLYTHAKALTPPSARGLGVARFLRRLCASLAFTLRLPISLQPSGDVVSLSPSVQSSQRQSSSPTKMPDYEFFASITLFIARLRLAWWILIRDLFEVLEFCLVLYSELVFEVLLDPMSAFVDRQVVSIRILFLIEPINLLPARVIDLLFRCENEVPDFGDNTMIPGRRNRTYMPSLDAGISDAPLETLSSPGGCNSDESVPFWRDNGVNVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHL7</accession>
    <name>K1VHL7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Minichromosome loss protein Mcl1 middle region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHL7"/>
    <dbReference type="FunCoup" id="K1VHL7">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHL7"/>
    <dbReference type="eggNOG" id="KOG1274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004219_1_0_1"/>
    <dbReference type="InParanoid" id="K1VHL7"/>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="321"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="628"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="102789" checksum="F2C5FBE971FD8FF8" modified="2012-11-28" version="1">MVEASADAITTVPCHLAGITRVAFSPDGSKDHLVTASADNVARLFTYPANEFEGYVTRSPGVAIRWVAMDQKGEQVAVCSDDNIKPVRSAAWDPEGKFLVTAGCDGKIKIYDTTGTAPACVKIMEGIIGQTDVDGNYFAVPLRTNDIGIIAKDGWAKLPTFSQDGHKGPVSELAWSPNGKYLATAAGNEIIVWKTEGRQVVSRYTYEDGEVSGLVWSPKDNMIAFTALDGSFNRWKEPVPSHEVSPVLSDAAVAKKVDKLLDDGLFGDDDDLDDQGEDLGEDLGDDWIVDDDGGLGAIDDSEDKWTKGRTEVVNVTKAQPAFVPGATEWRSKKRYLAFNMIGVVDVTDQETHNVVNVEFHDTSARRGYHFSDHNKYSMASLGEQGIAYAAPSDKELGTPSVVHYRPYDSWGSSAEWTVNLLDGEEPVAIAAGGPANGMGAVVVATSRGFVRFFSAGGIQRYMWRLGEDVVTMVAGKESVLIIHREGGTTLDGCQNLHYSLLDIDSYDVVQQGRVPLPRKVTLTWAGINNFGAPVIFDSDGLLSVLDRFRRPGQARWVPLFDAEMLRDAAKKETYWPVGVTDSHFNCIILKGFEKEPWFPRPLIQELDLRMPLLGLDNAQAQLEESVARSSVELNLTAEPSRERTVNIDKELLQLVQGACKADQLARALDLTRLMHSTSTLDAAMKLATFYHLPGFQQRIAKVKEAKEREPVRQVREYGYTAPRPRESNGGERVERQFGDFAPSTRKRSFAGKGNGKARAHTPQASAQTFIPETPDAEDEYAGDNSAMLLDDMEEQAAEYEESFTSPPVKRKREAESSLPSLPSLPPAFSKEAPKNPFAKKPPASNPFARPGGTAKPLDSVKSTSFFDRVDDIEAHKPKRGKLATGAKDKSKQTSLSFAKKPPLRAQDSMTETEEESLGVLEETDSNLQETLVDEPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHW8</accession>
    <name>K1VHW8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHW8"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_581649_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHW8"/>
    <dbReference type="OMA" id="FDSHHRN"/>
    <dbReference type="OrthoDB" id="2596937at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="551" mass="54637" checksum="282DDAF5E3931C7A" modified="2012-11-28" version="1">MASNEHSLPLGNDPSSPTSSANATPDPPTSSAADTGSEPSQVTPSSNGGGGGGEPSPSRTMPSPQPSSDPAGPTTSQGGGGQPSPSPSQPEPSPSSNPGGGGGQQSSSGGESTPSAQPSSDNGGGGETSSNNGGGGGGQTSSQDNGGGGNQSPSPTPSDNGGGQPQPSSSNGGDNNGGGQQSSTDGGNNGQSSSENNNGGGGAQTSSEGGQSSGNAGSGSATPSTSHSVAVVTESQVVTNAQGGSSVIYKTVTNTQAVPTLAGQNKSHKSSNTGKIVGGVVGGVGGALVLAALLGFLFWRRRKRHEVAFDDKMFDPHHSTRHSQADPLDMAGDLSPGPASTEAPTIEPYPFDQQTMTTAAGAGVGAGTAAALSQDHSHYNYEPSQHDYNYADDGYNPNHYGATYTTQPTMQMPDAQHYFPNQGYSDYSGYGPMGTGAAAGAAAGAAGAGVGNAISHDDYASATPAAQAKAREAGAAPMSPDSRPASRTSSRPLSSVYEDALMSQDGHRRTPGPGMMSSNQSWGHGNEFEDAPEHLQNEIPPNYHSIPSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VII3</accession>
    <name>K1VII3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FUN34 transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VII3"/>
    <dbReference type="FunCoup" id="K1VII3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VII3"/>
    <dbReference type="eggNOG" id="ENOG502QUJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_1_0_1"/>
    <dbReference type="InParanoid" id="K1VII3"/>
    <dbReference type="OMA" id="AMHWAIS"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26612" checksum="3E7F25FBE414C50C" modified="2012-11-28" version="1">MSATELNGNHGAEVKAQNQASDSASGYNQGPPISRFITPGGNPMDTSQPAFPVFHRKFANPAPLGLLAFGGTTFVLSLYNAQARHITVPNVILGLALGYGGLAQIIAGIEEWACGNTFGSTAFTSYGSFWISFGVLYIPQFEVLTAYAGKGHMLDDALAIYLTMWAIITFIFLLGTFRSSVALFLVFFFLEITFWLLAAGHYTGHKTVTKAGGGMGVVTAFTAFYTALAGLLTRETSWILIPTGDLSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIP2</accession>
    <name>K1VIP2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01674</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIP2"/>
    <dbReference type="FunCoup" id="K1VIP2">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIP2"/>
    <dbReference type="eggNOG" id="KOG1825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021763_1_1_1"/>
    <dbReference type="InParanoid" id="K1VIP2"/>
    <dbReference type="OMA" id="TLIWRHY"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="12">
        <location>
            <begin position="169"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="355"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="617" mass="68861" checksum="D93D62989DB2DADE" modified="2012-11-28" version="1">MVMASKPRYWNVAFPLVVVALSVSPREVFMEHWQACIDSISSKTKDRTSRAVGMNAFVRLLWVYLNRCPESSTSTRRRLEGLLRNHFPVNTGQLLPTDLPLDPFQSPQCLTSPILFPRTVATQNRIAMAVEAKPEAGDVLRRPSVPYSSLPELSKPFLIDPSKRSFKHQYANVYFVRLVELRPIVEEHAKRLWAERHCGYIFRNYLTLVKPRLLPRILDLNRGQPCYIVGTVYMDMPLKPNVLEDMARSNWIAPPAPRPKFYSSQDAVHLEDESGRVRLVGDVIRKERDREGGGFVTGVIMGVLGFENSSGDFEVMELCFAGMPDVYHPSSLGTANGKGKARESMDVDDESKTWVALVSGLSVGNETSAPDLKSELLVEWLMGENGGAQDQLEGSRIARVIFAGNTLAAPIKGQDDRKIKADLNHPTKNLAHMLSDLLASSLPMNLVPGPSDPCGAVLPQQPMPKVMFGGKKMEGLECNTNPTWLEIGDRSFLCSGGQTIDDVFKYLPGKSRLPMAKRTLEWRHIAPTAPDTLWIYPFPDNDPFIIRERPNVYVVGNQPEFETALVGDEDKTRIVMLPSFAATGTVALVCLETLEVKTVAFEVPPWIGEVKVEMKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ10</accession>
    <name>K1VJ10_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ10"/>
    <dbReference type="STRING" id="1220162.K1VJ10"/>
    <dbReference type="eggNOG" id="ENOG502SE22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1548705_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ10"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="173" mass="18599" checksum="C2210FA2264AFF6E" modified="2012-11-28" version="1">MSFPGLSPTLAAAAAARRAEREKEVEAVRRRVRQTMPPVPELRFEVAYLKSILPAVSPKRRAVITEEKDGSMRFDKPSNQETAVAIYNAEPVVVDWGRVLAVTIKDQIISPFLQGVFWGLLSVTLGSAATSLKGSLFGHKVQIKAPQVGDDGRDAAGFRAGGKVAAVKAVTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK32</accession>
    <name>K1VK32_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MutS protein homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000369">
        <property type="protein sequence ID" value="EKC99541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK32"/>
    <dbReference type="FunCoup" id="K1VK32">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VK32"/>
    <dbReference type="eggNOG" id="KOG0218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_0_2_1"/>
    <dbReference type="InParanoid" id="K1VK32"/>
    <dbReference type="OMA" id="HTSCEAF"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="987" mass="108399" checksum="A6E36CC4E808E6E7" modified="2012-11-28" version="1">MGTDGGQTRDDAVDLTTPPPDEPPAKRAKVSGYFANSKDDSSKLKATFNSVPRLGEYRLSRNPDNAPLPKQRTAEEEQRHEQWQNAVLGRKFFRRRSLQLDDAAAIALREQLGEEAGEQTPASGSATPATPGPEEDTQPESSAAAALRAKFAAPPAKGRGKKKEDIGPSGLTYTPLEKQYMAIKERWPGVLLMLEEILRRRRKGTVLLLGPANVRLPRENSASWHSRTATSTRLRSRLISLGYKVGVVSQTETAALKKVGDNRNAPFTRELTHLYTSSTYVEESSASSSTVRDAPVVPGTASPSTGALVTIVEDADDKRSRIALVSVIPGTGEVLTSDSRIRNELETRLTHLQPAELLLPDDLSKETRKVIDHLTVGRSTADVRKERVDQVDYTTAFDYLTQFYKEREAIDLTREDEEMGDEASREDGEANVDELVNFPKPVVVALSMVVKYISADSSDLKARADAIEEIITTNSYQVEKLRNLLVNMPDLVRGLTRAQYGKTTPNELSAILTGLVRISTEFRPENANGFRSDLLNDLVRKLPTIKDAASDLLAALNMKAAKNDEEAALWQDQDRYPAIQDAKDCIDVCTMELDQHLAQVKKALGRPHLKYVTVAGIEFLIEMPHRDAKIVPPKWVKVSGTKAVSRYHTPEVINIETLALEAKGAFKAFQEEVAEHREFLVVARELAVIDCLTSLANVAQANGYVKPTFVAEPCLRIKDGRHPMVEALRDDQYVPFDISFGDKEGRAKVITGPNMAGKSSCVRAVALMVCMAQMGSFVPASSMTLGIHDAVQTRMGASDEISRGKSTFMVEMTETSDILRTVTPRTLVVLDELGRGTSTFDGVAIAYATLSHLAALDIPTLFVTHYPLLSRLEAEYSTVSNWHMAFTEMPGPSGPEITFLYKLRRGLADASFGIWCARLAGLPDELLETAQEKSERMREETRDRGRAAVGKYLRALVGGDLTAAEKLEGAMAYVDAAGPGGRVEVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKA6</accession>
    <name>K1VKA6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKA6"/>
    <dbReference type="STRING" id="1220162.K1VKA6"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2401238_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKA6"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="93" mass="10918" checksum="48D8912F70973352" modified="2012-11-28" version="1">MSADREMRTGKHTVRDVFCGVCDEILGWRYDYAFELEQKYKEGKFILECELITERPESKARDPVFRPRIEEIVRESTRPDAALAQQIPILNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKG3</accession>
    <name>K1VKG3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKG3"/>
    <dbReference type="HOGENOM" id="CLU_924979_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKG3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="301" mass="33025" checksum="75795E8290EEDA6F" modified="2012-11-28" version="1">MSKELHGIQRKFGIDLLFNVVKQCAEVGCSQQLGSVWFLLQEHLQPHHLDRKVRPNPVQVSNNSLLQCLRLVYDAVDPGNPKDNDELLGRVALSFQDSSAFKVASLKHTARASILEVEKNEPLSVVSCDSGLAIGAWEPAIHLSRSDALNALAWPGVHPQSLEAREILEERDWGPYVWMSMYVPNQVHCLCSASGEGGIKPLVVAGDARLRWELLNLGVLVREKVLESVVFGQLGPRCENPSLVGRGSAEMVVESLLSSVAPGTAHLAGDMQAMVRQELPDEIDDVRKALKVNLRHDGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKG4</accession>
    <name>K1VKG4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKG4"/>
    <dbReference type="HOGENOM" id="CLU_826880_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKG4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="336" mass="38301" checksum="7A52B7CE2AD0D809" modified="2012-11-28" version="1">MKPDHVIVSSRAVQRAIKSDVYRSTHKLGFEADDFLAKLFDFAEHTCITWPSDKAPTPKQLFRFVRRSEGIDNKVIKRIRKSADFDSHMARSLRLRGSATFHGLDSVSESCLYSPEGSKKRYFSRSQCKFGDVRMEGQSLILNLNDTAPDQPLPPHEYDTFEFISTGDIDLTALRKEVKPYTTGPHCLFMSAYYDNIIATAANYRLRARVTAAVEKLRRSRDVLEAYLDNRSSATPTDTRDAANADETYKWARITLRELEEYPGAHEDLFEDKLYDLFEEETANFPLTSERLKITALEDAEPCSACGRKDFEEEETLSSLIAATQSLPLMTTRMKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKT2</accession>
    <name>K1VKT2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKT2"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031002_0_1_1"/>
    <dbReference type="InParanoid" id="K1VKT2"/>
    <dbReference type="OMA" id="GPYQLYG"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="448" mass="46959" checksum="6E9297C26038762D" modified="2012-11-28" version="1">MKTVTVYGATSYTGSTHLLPYLDTNYAGQVHLIIAGRNRSKLDALNASLSAINEKHRSVAALSLDDPAAVKALVDKSDVVINLAGPYGLYNALELIGACAKAGKHYLDLNGDVGMLAADVVPRWDFAASQTGSVIVPMCGFESAPGDLIVYEALRTLQNHVGRNVGIAHSTTFYDIVGSVSGGTMASVEAGIQSGSAADGAQEAALLGQASQVPSPKVKLVYEPPVRVAGAPKYGAFFIQYLPNRAVLRRSWHLLRLPPSTVSHKSNGQFSNDSEPLPADKVTFEEAMSGMGARKVTSWIGAFLTSLVVIVFGALYVSAAWFRRLVSPWVPKPGQGPTLEECAKGSTHLINVSVGHDGTAIKTEYVGKGDPGYSHTAMLLAESALSLALPAPKGTKLPPLADVGGVLTPATAFGGVVIERLRLAGVADINGQIVQPLQGTHAEGKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKX4</accession>
    <name>K1VKX4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKX4"/>
    <dbReference type="STRING" id="1220162.K1VKX4"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="InParanoid" id="K1VKX4"/>
    <dbReference type="OMA" id="IEAPNAY"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="74" mass="7656" checksum="96271CC7AA9C0CA3" modified="2012-11-28" version="1">MTCGGCSGAIERVLKKNIEAPNAYVVSLPTQRVVVYGPSLPPFDTVTEKIAKTGKEILSKEEIPAGGAVPAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKZ7</accession>
    <name>K1VKZ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKZ7"/>
    <dbReference type="HOGENOM" id="CLU_390384_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKZ7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="707" mass="75635" checksum="AB9BF3F2EA1939CE" modified="2012-11-28" version="1">MITLPLHEIREGDAINILHSLLFRAYKNSDWSFPKQAHIVVPAEALILGGGKEQKELTKSIGVMMRKHTPGPWAGIMLEKWDKEDELGGEPSARFIAGVVSLREALPSNPFVVLVGPSCAIDVLRAIKLGIKDVPDCTTKSVSRHRGTADISVFEPWPSPRPRVPRQPVSCMTVDTNLCVWTKGGKPEGMLQSLCQAAASQSVPVMLLPEVAREVKPPPPSGRNTTPSDPKRRAEHAYWQFVAQQSTAEIGERMLFLDVLTACGHQNGSADNAESEQNRTCIHLVGGERWTGDRAILLEHQELHRVMASRKPEAHKDTHQIVALTGDEELSVKLHMLGCGSVWISPPNNTRGQPAPASLEQANHLVASIVEAEKLKAEYAGEGDDAGRPGGPAHSETPELGHTTAPASANVGGSGCLGDTRGEVKIKSKNDQHGDNSDDNEQSELEEHRSRRARSGSEHDVVIQGGSGSAQPEPSRLCASTDRPGPPKAMGMLPIGGDREAGGQDNAADASHPFKAVEMPCVGGDGEAEGQSDDADASDLFNAMSVLQVGGDREAGGQGDAVDPASTSEQRTVENQPRASAERCALLPLSAERLRDHVARDETEVSGILGAATASGSASQPKVDEIQFDKIQINELQFDETQFNDNLLGEIQHETQLDGIQVGQNLLDTDQLDANATNSELHGSGAVAGKERDGRGKSVDEGKINED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL62</accession>
    <name>K1VL62_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL62"/>
    <dbReference type="HOGENOM" id="CLU_370140_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL62"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="747" mass="84234" checksum="E83233B724E7EE18" modified="2012-11-28" version="1">MPAREVTPGPPETPFATVDESYHQWLKNTDTCKGTSLCRELDKFFAASRRSELSMSFLDDLREIAFCPSLITCTCPGGTLIHPNCRPATGRLHANHEWSFDLSRPGALQDWTWRRLLEYYWYYAWPSPEAEFPPLSTSATTSFESNVLGPLHHPSRTAVHQGLTMTLMRHAPPKPNPRSQLRNKWMRYLCRGADTLPAVDQFPPPSPAVGTMVLDNQFDEEAAVGLWGIFERCDIDISTCAGWTASGFSRPATIADDETVSLRSINGVTVVFLSLVAWEHRKVFCQSWRLQGIILSDLLRHGVGWLLFQNRDPYSMSISTQLFFQPLDLRDTNEGALMWSSIFEWLPPDPGDVFPSTWSEGRARVLLLFRTWATRYATKGPIQDSLPRYLNVLRDMSPAWYEDFDWQVHDAHVRFTSSCGWALGTGVALVVERYEQMLGSDLPDGAHTLRAQVADFFREYFDTAVRTSGRRTRPFNGLVSLRHWSLHPELRRLGTTFDSEWHDFLHRMDASNQVRWENRSALMRHFRTAFLDALLTRVDLDEYWRDTARVVRSNLASPVSIQLVPEADRNQLLTFHNTQGADLGADFAAKFMIGLNEKWEDRWDGEPSEMRETVPQADAGDPPSEATITELKNEDPDPDGPNPPPPSDKPGRAGPHQLWISVVLAFLALVIAFSQGRLGNFSPGHLQTLTSDPAQSISTGHIVARYEAGSSLVFTVGDRVDVLEQPVPGWVKVRTDAGSVARLVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLK9</accession>
    <name>K1VLK9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLK9"/>
    <dbReference type="FunCoup" id="K1VLK9">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VLK9"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_1_1"/>
    <dbReference type="InParanoid" id="K1VLK9"/>
    <dbReference type="OMA" id="NTPYTEQ"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="418" mass="46764" checksum="E619D7BCBE5E827F" modified="2012-11-28" version="1">MYRHSLRLARPAVRSAPRVLRAAPSARGYSTGNNGNNNEQPKVDLKRLALGGAAVGLVAALAAGYARSNPTRLDGTPCVEVIETFGAPWEPVHAIEQDDPKDHIVKTLEAVEASAPPDGEHEAQTFLRDHWIRPSGGEGSSCVLQGGRVFEKAGVNVSIVEGKLSKAMQTHMRQEHDSIPISDEPLPYFATGISIVIHPRNPHAPTCHLNYRYFETADPKDPSKTLAWWFGGGSDLTPTYFYPEDAEHFHATLKEACDKHDPAYYPAYKKWCDRYFYLPHRKETRGVGGIFYDDLTSTSPIHGGKNPSQEDIFAFAKSASASFLPAYVPIVLRRMNTPYTPAEREWQLIRRGRYVEFNLLYDRGTKFGLNVPGARIESILMSLPETAKWQYMCPTGDVKGSREEELIKVLKEPREWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLS6</accession>
    <name>K1VLS6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLS6"/>
    <dbReference type="STRING" id="1220162.K1VLS6"/>
    <dbReference type="eggNOG" id="ENOG502RBFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681834_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLS6"/>
    <dbReference type="OMA" id="SWHRRTS"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="404" mass="44888" checksum="E3ABA679BC18C088" modified="2012-11-28" version="1">MSSPASRRSLSTADWPIDPALENSQPSQPSPPPSPPRRITRSSQATLEASQPPPESQNEKEDEIVEIVSGPGPRRHRDGSASQSRRRPRSSSLENNGADVINPPEPKRRKTAEERQRSYAQGWETRRENLWAERILPTYSTGLDTDYSDLPPDFLLDSISQHAGRYFFDRGLMKNPKRSWHRRTSIKPNKKRRMLEQGGAIARVLRESGIQPSRLSIDSTAERIEGEQETEEEREEQGEEDGEGAEEESDRVLRPRTSTGSTPAEGADREGECSGSDTDASEDAYNPDKDADPESDEENPATNSNPPMTSSARAGSKQVVIVAPAGRTQQLREEASQKSRRRGPYIRRDMRNAIQGAGLLALGVLVEEMIRAQLKQAGYAPRQRDRRASTAVESDVEPISDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLW7</accession>
    <name>K1VLW7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLW7"/>
    <dbReference type="HOGENOM" id="CLU_442265_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLW7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="398"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="618" mass="68785" checksum="8B8C95791DD9BA7F" modified="2012-11-28" version="1">MWPTLREFLAEGFYPIPPIPPPRPGSQTTRATGIRQPSSQSLDLIEATPGQHITIKTNFDILQPLQAALESRLNLDAPVSGEIPLQFARAAADSRNAAVLEGPNLMDELKRAYDIVNNLVRCTLGKEAVSLGKWTVVGNQTGPQAHLAFDHNHPGQTFVSGTPDATCAVDGRRETPAIALLESTVTAMFSDDRDLRRQKATLRSDEGMIVYMSQASRKLRTWNSYLRNGTAQFWVNFMAQVWEEMHQYRAECVVITSWKFTSLFKRMGANLIEVSPISNFDDDLTGRLNMLQILTAFAVSKVDDPLTAWTDHPGTPSLLRRDSEELDRTGDATPMPCPLPAAITISVSGQPMNVFPNQQGMGENQSRSVAQLSLVYANDHGARDEFSKHVPKAGNYTVHLGEHIGSGRTYECYRVKDTNMVSASGGLVAKVVQLEQFPVRDAKWKRSRVATREAVKAEAALYTGALKPLQGDAVPTFYGLWTGALTTPGRVESKDFAMPNGEKTEPCNEIMVMILEDVGRVIADRSEYVGDFDIVDIVSLYERLYSANVVHGDIGVKHIMKMGLGELRLIDFENAWEVDPDKPREYVDLLDEKRTLLREFKQIIPPELENLVPPWEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMC3</accession>
    <name>K1VMC3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMC3"/>
    <dbReference type="STRING" id="1220162.K1VMC3"/>
    <dbReference type="eggNOG" id="KOG0086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="K1VMC3"/>
    <dbReference type="OMA" id="NTPRIFR"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="218" mass="24256" checksum="AE18B6A3AC15D60F" modified="2012-11-28" version="1">MDWDDGGTELVEAYGGQRTHDRRGVLLTNAANRRQEREAAAGQERFRSVTRSYYRGAAGAILVYDITSRSTFEGLTKWLEDIRALASDHIEIVLVGNKLDLAEDREVETEEGERFARDNTRFKLNGSDTKLTPDLTFIETSSLTGENAALPFHLAARSILAGIDQGNLDPDSAGSGISYGERQLRAVADTNTPRIFRRRRRDSISIREFVGAKDKCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMF7</accession>
    <name>K1VMF7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMF7"/>
    <dbReference type="HOGENOM" id="CLU_821799_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMF7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="37442" checksum="8EBFAA45D948D2F6" modified="2012-11-28" version="1">MHVAQIVVHASTPHSTSGRMSGLKFDPPQVSPVTEVDRRRFPRFRAYIRRRIAETLPESILQGAITEVVTDAIGTLDSRSEKEAILCVDSNIDLERLLGPLKHQRIPAHLMTWKDEPRSLGVRSTTSTKSGVHIPDITVYVKNVATGQIVVAHVVEIKWRAGVAQAILNMSQAHEAQQTTDGTFVLETTFCRLFASDLQELLEKSSELANSMPHDFAPSQQPEATKVDDIGIDVAQFELLWKHFQRARAHIQSLPPAPVGASAILIPTLVDPSFEREIVRRTPLPAPREESPSGDDDTEDDGADGDVPLQRLLAQFTLDGWHVKLVSPRDFNTISNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMI1</accession>
    <name>K1VMI1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-1,4-mannosyl-glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000308">
        <property type="protein sequence ID" value="EKD01901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMI1"/>
    <dbReference type="STRING" id="1220162.K1VMI1"/>
    <dbReference type="eggNOG" id="ENOG502QPVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038606_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMI1"/>
    <dbReference type="OMA" id="FEWPAGE"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="354" mass="41029" checksum="B87BC45DF3C9F24E" modified="2012-11-28" version="1">MALSRQHRRFLFLFLFVVVVSVLTFWSRLALAWRDFGYLTRPLWDHPERPFTVVPHYPRSTLSSSEWCSLHGWKPRTSTPKVFDAVIFSVEIDLLQLRLRELYDVVDGFVILESDRTFTGLPKNTTFADNKHLFDWASDKIHYAFHEGHELKAGEHPFDQEAQMRTSMNAALERAGVRQGNLVLMSDVDELPRASTLELLKTCDYGDVIHLQLANYVYSFEFLLGHDSWRASVRRHPSTGYSHGRVSETLLGDAGWHCSFCFKHIADFQFKMQAYSHADRSRAELLGEERIQKVICDGTDIFDMLPEAYSWSELARKMAPMQRTNSAMDVPRLLKEKPEQYRYLLPGGCEREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMX7</accession>
    <name>K1VMX7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07603</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMX7"/>
    <dbReference type="eggNOG" id="KOG0437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001698_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMX7"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1885" mass="208159" checksum="739E6D8DDD9566C0" modified="2012-11-28" version="1">MFKAISSAVSSVVHSRAASPMQPDHNTPGRYKEYCGIADALKGDDVPVSSADCAACKAPCAPTEANGAGTIAEAGNAWSGKTYEEYVDDKYGDLGTLPPAIDTDWDSDLAGSGGPNVARVVVISTGKSNWDEEDGLAYQINKYMETLPTSKGAKSKDGNPLKPSTYIKPSEFPPPSKPLTEPIKTRPALYSSSLVSQSDNCKDQTVLVFPDWKVVSDVENSRAGAKALYDTELGSTVGRAGLTLSSGGGGDGVFRKRSHVMPYRAIVLLCSHKTRDKRCGIAAPILRSALITCLEKNGVSVDESGASLAMPEGPALEELDGTDAEREAAVGKAISQIEGVKGGKGGQVGIFNINHLGGHRYAGVMLRSGPAHRSRPGFSTRYPSSMPVADHDPPSSPLSRPVKLAKMEDSIDISEATTALAAPSSVTSSRTTPVPSRVATTDSCVFGLQLVNDPSSPRAFFWSDTTPRPAKHSRTSFSLHFTILSDTTTTAADVGTNFFLEPSSIGKPIAQEEVRHLCELNPAVTGEAKVASDPSFFTSNTLVITSNVSPQVEDAIAELLWNMVDSHPDTTHTLRIDQPFPSLLAYSRDLNFDGMDSMEHSHVPWVVLLVRAATVWRESLPNSKEEKDEFKKLIQSWRRKGDEENFDEALAQAYRVWTPSVVPYDIAELLKDPATVNISSNNLHLLLHTLSKFLETAPHLPPVAPTLPDMHSSTKSYVTVQNLYKQQHLHDLARFSELLGSVLESIGLPDDAIPSTEVESFVKNVGGVAIIKGTPLKEAKTYEGAMKELINFGPDSQPQMSICIILAILASEEFYKLFGKWPGQEKGDPASDVAEVERLATKAIGTVHCNAEEIHEPLYQAIEEVLVIKISATLSLRRAALLYNHHSSVLCTKTVSQTRFLQTSSVTLAKKQQQKSKMSAPAKADAAATQPVVTMEKTDKRDYLIALEKAAQDAWAQDKLFETEPAPLPEGVSTYADFFEKGLSMEEVHEKHPKWFGTFPYAYMNGSLHLGHAFTISKIEFAAGFERMRGKRVLFPVGYHATGMPIKTSADKLIREMEMFGEDFSGNVAPEEPKEEKEAAKSNDPSKAKKGKLNAKSTGLTYQYQILELIGVPREEIKQFADPIHWLEYFPPIAKEDLTGLGARVDWRRQFLTTPANPYYDAFVRWQMNKLHDQGRIKFGKRYTIYSPKDGQPCMDHDRQSGEAVNPQEYTGVKMKVLEWGPSVTDEVKKATEGKNVYMVAATLRPETMYGQTNCFVGPTLQYGIYEANDNDLFLITERAARNMAFQGCFDGRPEGVFKKVADIKGDTIVGTKVNPPFGIVPEVYVLPMEGVLATKGTGVVTSVPSDSPDDYRTLMDLRKKPEMYKIQPEWAGVDPIPVISTPKYGDMTAEKLCTELKIQSQRDTKQLAEAKEIAYKEGFYNGTMSVGDFKGEKVEDAKPKVREQIIKAGLGFPYAEPESEVISRSADVCVVALVDQWYLDYGETEWRATAERLLKQMNTYVPETRNNFEAVLAWLNQWACARSYGLGSKLPWDPQFLVESLSDSTIYMSYYTVANLLHEDMWGKTGKLGIKPEDMTDAMWEYVLCDGPFPADSKVDKETAAQLKYSFQYFYPLDIRSSGKDLIPNHLTFWIYVHAAVFPEKHWPRSVRCNGHLMLNGKKMSKSTGNFLTMREATKKFGADAVRLTLADAGDDITDANFEETVANAAILRLHTACQWAEEMKKDAGQLRTGEFNEFDRLFQAEMDSLIENAYKAYDNMDFKEALKLGLYDFEAARNWYRLQCLPENGGEGMHKDLPIDGRAFKKKVLAQGKRAFGRSLPFSELDAIKLLIPYIKVNLKFAEVDAVSVNDAKAKIAAEGEKDGWSLERAEASEPGNPSVQFWNIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN12</accession>
    <name>K1VN12_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN12"/>
    <dbReference type="HOGENOM" id="CLU_074425_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN12"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35251" checksum="0CF7F2C77B4730E7" modified="2012-11-28" version="1">MPQVTVDAKFFPHIIDEIFAQASRSTLLALRINREWRKRAERMLAYHVRVTETVTDSESLPRKTPIVQSSDGDMLGVIKVGSPDSAAPVFLSSTVVIDLHVPNFDKKVAPILTHCLTPKIGRVVLFFKDDALHGRDGFYSRYRLNRIPGPKQLVLHLRSHGRADASYFLDIRDSFGELGGMTLILHPREPTRWNFGPHSLEYKVESQLSFLADFVVFAYVKNVPVTVVNLACRKLEGLDEQVYSYEDVKNTLLERITRAKQGYTSYPVGSVYTPVRFLSLDEYRAEVGEELFQIDTNEGRLWPPHLLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP16</accession>
    <name>K1VP16_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ricin B lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP16"/>
    <dbReference type="HOGENOM" id="CLU_018242_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP16"/>
    <dbReference type="OrthoDB" id="2590151at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853949" evidence="1">
        <location>
            <begin position="17"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="506" mass="55927" checksum="6B7A1AC46024B3D7" modified="2012-11-28" version="1">MLSLLLLASSALGGLTVGPIGPWTHPDDTPAFPFTDKDGTFYTQSAHAGYEIDASRVWSFFTGPDIDSLKLNTAITHSFDPNEPRDRNDNTTFRCTVRSPTGRESTMPPPTSSYKQKNFCDLAGMWVDPDTGDWIGLVHNEFTPSPFGDGLHYDAIDRAISKDQGRTWTITEHLITTPFSTKRGDNVTFPQSTYYYGNGDPRVTFDLKGGYVYVFYNSRVVDKGGSWKLFYPHVARARLQDKFTGFKKYYKGSWDQPGVGGKESVLVPTSVDKNGYSAIEYNPRTPGKADEQVAAGKAPATSRLFVLDVTYNAFIGKWIGEPQSPEKDASPQEYYVCDDIAVPKWSLLGTSGETYKTSSWYRWFIDSVSKTSGQITGRKWRGYCSFYCHDKKNGDYIEISHDQADGLKPLSGTLGGYTLKATGDGAYTLGKSGKALGVTERKWGSAATLGSGTDAKSQWWVIPDANGGYRAVNRWSTLVLAGDKTVPARHWDNGSDRVADQILKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPM0</accession>
    <name>K1VPM0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPM0"/>
    <dbReference type="STRING" id="1220162.K1VPM0"/>
    <dbReference type="eggNOG" id="KOG4173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069441_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPM0"/>
    <dbReference type="OMA" id="ECHDELA"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30713" checksum="E8C07FD8AF7150C3" modified="2012-11-28" version="1">MEWRNKRRRSESISSESEDEGSMRSRTPSPEPAHTTKFHRGESPPKELLCTLPPTCSQPGKAQAFATQAELDAHQASLHQWICRVPIKDKVGRVGEGDFVIVPEQFSGRSTFGKGNKWRECGKVFPEERLLDLTHDPIARERQERGEDIFACFLPEGQCDKLFPTPKKRRWHMVNEHHYPHDYFFSITNHGVNQITRQEGPAASLIRPRRDPPPPEEQRPKPARPPRRPSDDLMSIDDLTTKMESLESSLAFVPSGVRKARARRAMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPT2</accession>
    <name>K1VPT2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPT2"/>
    <dbReference type="STRING" id="1220162.K1VPT2"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_883194_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPT2"/>
    <dbReference type="OMA" id="HANDNIP"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="128"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="346" mass="39027" checksum="5B51312FF8E0F1F6" modified="2012-11-28" version="1">MDTVPLTDSSGFEGRSASLPKAKDMSHHINQITKNRSPMALKELYRYASQPGMQAFAGGIPSPELFPFETLSAEIQRFDSLPLERPRVPTKPKKTLMEWLFGGNLQFTIPKYASDPTDPMAIQLATSLQYQAATGPPALPKFLREYVEKVYQPGYADWDVLVDVGATDGFGKAFNMLLTMGDAVLVEEWSYPGAMNAYMPFEVERVAVRMDGEGVRPDHLEDILANWDQRTEGRPRPRVFYTVPTGQNPTGATMWHQRKKEVYAICQKYDVVIIEDDPYFTLHCGEYHPPGKKLAPLVQRSIDEQKKEGKKGNQAFIDALPPSYLRFDTDGRVIRLDVSKSVVEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPU7</accession>
    <name>K1VPU7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPU7"/>
    <dbReference type="HOGENOM" id="CLU_1714613_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPU7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="153" mass="16538" checksum="B88567C2F372C0F9" modified="2012-11-28" version="1">MKRKLSVASRISSSKALVSKVHRGLGLRDLTTVFNSAPLDIHLACKRGELASGDRADPSPHRLIRCEVSDGMLPKPRNRADSQSTLNRTLVRSLTVSFELILSPPSPPYGPRCGTSSPQFQVAQVPPSSKSRVIGELSKFSSSVDPQLLDSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQJ1</accession>
    <name>K1VQJ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQJ1"/>
    <dbReference type="FunCoup" id="K1VQJ1">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQJ1"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQJ1"/>
    <dbReference type="OMA" id="IYRHQWQ"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="100"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="396" mass="44278" checksum="B7B7B3845743F809" modified="2012-11-28" version="1">MAPIATETQPETALPSVQDLKISNNANGNKDTVQPAKKKLQWFSETGLPKSAYPYEHLLPSFDRDVTYGTLEPFEHVDPGHAAKEHSDPRAFLAEADIDLLTPDFGSEVSGVQLHKLDAAGRQQLALYVSQRGVVAFRDQDFIDQDPSWQVNDWGSFFGRNHIHPTSGQPKGYPELHLVYRAWGEDPGDGLDKRSGSSSAPPGRVSSVGWHSDVSYELQPPGLTALWLYDSPTSGGDTAYVDARAAYNRLSPSFQAYLETLHVVHSGHEQANFSRERGADPKLTAYAHVRREPVKNIHPLVRRHPVTGEKALYVNRVFSRKIVELKDEESAALLELLYQIIERGLDFQVRVRWRPRTVVLWDNRITAHSALADFDGVPGSRRHGARVTPQAERPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQJ5</accession>
    <name>K1VQJ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQJ5"/>
    <dbReference type="STRING" id="1220162.K1VQJ5"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="InParanoid" id="K1VQJ5"/>
    <dbReference type="OMA" id="QFMMYEL"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="108"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="320" mass="33851" checksum="8A641449F9DCA469" modified="2012-11-28" version="1">MGDSAIHALAGGVGGGISMALTYPLVNLSTRAAVATKKSDMTLVQAIKKTIHDEGLSGLYAGLGSSLVGIVFSNSVYYERGLTPQAFYEETRSKILRRRPAGSTSSALTTGEGILAGLIAGTVTTLVTNPVWTVQAYQSTRGVTNESGKKEKPTASSALKAILKQDGIKGLWRGIGPALILVINPVIQYTTFERLVSAVLTWRAKRSGTTSVAGRGSLTDWDFFILGALSKLVATGVTYPYLVVKSRLQAATHKYKSSITAVIQILKTEGISGLYAGIGPKLLQSALTAAFMFVAQRRIFELVKSLVVAAQQKKAAALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR87</accession>
    <name>K1VR87_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR87"/>
    <dbReference type="STRING" id="1220162.K1VR87"/>
    <dbReference type="HOGENOM" id="CLU_457225_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR87"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="597" mass="63134" checksum="DC11A358EC42D804" modified="2012-11-28" version="1">MKASKLLRVLLYAVVLPLALLTCVWELIQVIVNSVDIMKTGLGPIGVDKSYMGDLGGGGGSGTGSGSGSDGGNGSGSGLGSGGGDQLDSNPGSYRAMTRTTITGFGPVVTWMTGPQTRYYTYTGSNLDIPRVATVTVRAASWVTTDAPWTSTIFPTRFEYFTRRRRALDTAAPQPVATRRDGEGRASSAAPTHAPTPTAASVVKERAPTPEMEAAPLARRQYGVSLDDLREAAESGGSAGYVGSVTMEAEVEAAFLNKVPNFLGLFWSAAVLIWLGILPCCSAKSRAKAAPRSLDSMEKTTLGFWISGLILSLYTVVVVGYNAGMSSYYTATGLSVCIIVFIWLTTIVLFSVWLWLRRWGRKHAKGQLHRSMEAVEDEDAGIASPGSDPALESKVDAADMPLKLPYGANEAHSGAFPSTSSTPVTEQYAQPQYAQPAQSALPAQPTQPAYGQTQFPYAPPTSQAPVAPAGYTYQLVPTGSAGAPSAGAPSMGAPSVVAPSVDAHSASSPSPPPKDYYSGMHQQHGAPVSPGPPSPVQQYHPAPASPEQYHLPQGQQMAPGQHFQQTHQGYHGYPEQHQPGQPMYQPQPVQPQQNFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR89</accession>
    <name>K1VR89_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nam9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR89"/>
    <dbReference type="FunCoup" id="K1VR89">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VR89"/>
    <dbReference type="eggNOG" id="ENOG502QTS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041823_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR89"/>
    <dbReference type="OMA" id="GDMFQVE"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="366" mass="41360" checksum="E7C12C8B24B6A889" modified="2012-11-28" version="1">MPQRPVGVRDVFNFRQAIPRMSWSPKNLYNMWRRTAPQGDLYARTGHDGQLHGAKLYQERWNAKRLTKGYHADHLPSKKFGRWYLPQALPVMRHNSAKSDKRQNDLSKWVEGREAAGGRTEMNKRLAQLQKDGLSPVGTMMFAETERRLDVLIFRACFARSVWAARSYVVQGHVRLNGKLCRNPNTLLNPGDIFTVDPAMIPFINPRAPKEGEAAEKAEEDADEALANSENSDEPAAEAAESAAAESAESAESAETEGEGEKKEKKGKKDEKAEKVHAPGEYFKLPDYAQPFIFVPAYLLPSYLTCSAVYVRHPTARAAYSEIPSPYDAAGPLMSMTWEWYQKVAPRMRPARRARLLGPERKNDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRC0</accession>
    <name>K1VRC0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRC0"/>
    <dbReference type="HOGENOM" id="CLU_806951_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRC0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852397" evidence="3">
        <location>
            <begin position="22"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="344" mass="36201" checksum="913BFD368EFA297F" modified="2012-11-28" version="1">MPRTRPVLLVAAILMATAVLAAPQTMTAATAPAATAPGIPDDLSPGDMDGNLLTATPTVTPIPKISATSSAAANSSSVQLSESALAGIIVGCVLGGLLLGLVSSAIIFVCLTRRHEYYEEYEDDTAATSPEKLHATHSRQAQPPSPSPRSPRAPVVPPRPNAGLGMTALQPTESGTSDPVAPSLPSIHCTSLGTPADWEAERARINPNVLHVPTGTALGYSDSRPITPTRFWRGLRDRRVSQMTIRSAKTKAKRASIVTVKSMKSGKSRRASILTARSKLSGRSKHSNKAGGGAEAPPVPPLPFTRRVPVPPLSPGLSSMPPHRPKRRVHMRLITPDPPAQFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRJ7</accession>
    <name>K1VRJ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRJ7"/>
    <dbReference type="FunCoup" id="K1VRJ7">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRJ7"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_1_1_1"/>
    <dbReference type="InParanoid" id="K1VRJ7"/>
    <dbReference type="OMA" id="RAHVHCW"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="399" mass="43799" checksum="7B4D439C05B038A7" modified="2012-11-28" version="1">MAAIRPSLRPRALLRRPASLLRRYEHSTPDVTIERGGPVNVDRLCQVSRDFRNAQIESAFLATRGDDVYGEDPTTIELETRLARLTGKEAALFCSSGTMTNQLGIRAHLQGPPHSIICDHRAHIHLWEAGGIALFNQATTHALVPKGKFLTAKEVEKNLHLGNDHHIAPTRLICLENTMNGVIYPQEEVVRIGEAARKHNIPMHLDGARIWNVAADEVEAQHLDSSKEEDIQAVMSNLLEPFDTASICLSKGIGAPIGSVLVGPQALVDRARWFRKAFGGGWRQSGVLAGMADYAITNHFPRLARTHILAQRLAVGLQRHGLRILAPVDTNMVFFGGLDSQLVIDALAALASPILLDSNRCVIHHQTDAEAIDEFVSVVEQLVAEHGVSEPTEDEMLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRY0</accession>
    <name>K1VRY0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRY0"/>
    <dbReference type="STRING" id="1220162.K1VRY0"/>
    <dbReference type="eggNOG" id="KOG1875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004632_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRY0"/>
    <dbReference type="OMA" id="QLEILWY"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1146"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD02252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1223" mass="134929" checksum="5427EC87D48E9B53" modified="2012-11-28" version="1">MSYSRVPDGAQSPSGPPTQPPAALHQLPQPVASSSRNPQLGPNPYFRYPTPTPEQIDEELPPYWETENVALGPMLDRLSRKGYGDMKVLVEQTLPPLAMRQKPKQIIEYAKTTRQAVLKYLALLRWKASVDMPSAPTTAPPAAVGAHSFPTPHSNGESNDTSPSSLPIKKPEEQQRGKVTDARRIQQFLEHQNAQHEAAIAHIRHVTSMVETLRERNADLLTAMSLRSAGNYTRLPSMLEESFVPRPKLKPAKVLDTVEKLNEHLLYRLRCVDYLPPSLVVEKVADGRAYVRGGGEAGWRAQLTVAGFDDDARWWLTGVEWEWTAKGQKKGFAPDERQQILDMVNKDILEPRPIPEGKEGSVDAPLVRVTNFLQHLSLSYQLEVLFSQALTLSQQTYRNQLIVDIDRTKKELTLKYWVRPRQAAPGQKRPGGPSTPIVGGIITFAITESKTPINDAERLLREVSAGTDVPADRPVGLELSVKWTVGDAGTGGGLKAGNQMDGSLLRIDSVGLSMKEILGTATRAHASFIARSTFSPLLANPRLALDPLNLPKLIESESAARPVQFIIPLPPAQGAAHFTVSVSATTGLIEIEDSMKDSGQVLENKRLLQTKLATASVNDQKTRLADDLHRLITAVILETIEDKMRQLGMQPTRRIPLRSHELTKTDLQPSSTIFVPLAVSQSHYFVSKITPEGVAYELLWLLRVPMENGGYRMAVGDRTPIDLQKLMERRRTKAHKRARDEDEVQQASDAWNDAQDAQAQAVKCRFDVKAKDLRDMFFYCNALVAQTIVEQQLKDRGIPYIPRYPDESDFPAPFSRSALAGMVPYICVNASELFKDGRATEVAAPQVYFVLKDWWKGSKCSVETIVRLQQASMSNDEAATSGVDPASSSASRAEGIKYDQATSTVRFHAPNIAKCVPDFLEQWERLSKVIIVAGEVNRLNKTEAYRDVRMLSFDLCTATLQYWDGFQVAITYTPTSDSYEVPFFKGDESASPHQLLAPLLSHHLNELTAQPSYVRDALGSNGKQFISLLRATLPLLLEQEALRTQSASEFPALVVRSVFDYRFVWDQFGTTRFALDITLSGNCRSFLLSDGARPRPPSEQVDLSCGVLTPIPNFDRVVQKGYQAARLAKVATPASMSTPGAAVAMTPKTPKTPGAGTQGKDARTPKTPAKVLIANGRAVGMPLPPAIKLDNGTTLMCAATVLQDVLRAMVAEIETQVAAYQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS39</accession>
    <name>K1VS39_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS39"/>
    <dbReference type="FunCoup" id="K1VS39">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS39"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_7_0_1"/>
    <dbReference type="InParanoid" id="K1VS39"/>
    <dbReference type="OMA" id="IDARIHI"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="93"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="389" mass="41133" checksum="CEA05C1C6AB01A4D" modified="2012-11-28" version="1">MLGVGFAPSRTSTTGGLALAALSLLFLSSFGLFRRLAYEGFIALHILLGIVLLAALCVHRPMYRAWAWGGFVIWGFDRIISLGKMGWASRAGKTGKTGKTGAVVEVLGADVVKVTVTTGMKWNPGQHMFLTLPSIALQQHPFTMASLASAASDASPASPASDASAASDTNAAREGGEAVFFIRAHKGFTRHLLSHPGPQRCLIDGPYGIPPALTHYASVTLLAGGTGISFCLALLLGLVRDARRSDSAVGLVHLVWNTRDEDAVAWIKGMIEMEMGGSAGRMEVRVDVHRTRRGVETATPSVVSDKDEQGENDALVSVINVLEGRADVEGTIRRNIASTPNDAGGMAVVVCGPSSLNLETRRAVCAVNTPSAVAKGQPPIHFYSEQFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS45</accession>
    <name>K1VS45_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase (Ubiquinone)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000250">
        <property type="protein sequence ID" value="EKD03421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS45"/>
    <dbReference type="STRING" id="1220162.K1VS45"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="InParanoid" id="K1VS45"/>
    <dbReference type="OMA" id="WKLNHMQ"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="411" mass="45291" checksum="5A4F76EE5A8D8318" modified="2012-11-28" version="1">MVSARFAPVLRTKAMARQPRLTRSIADLTILNQPTTSKQVPITKAGPSNGGRSAVSGHTVTVFGCTGFLGRYIVSKLAKEGTQVIVPYRDEDKKRHLKVTGDLGVVVPLEWDARNPDQIHECVRHSDTVYNLTGLDWESRNFSYEDVNVKTAGLIAEVCAQSNVDQLIHVSHLNANPNSSSRFYRTKYDGERAVRNAFPDATIVRPGPMFGAEDWFLNAAAQYPALFKLNGGNTKFMPVHVLDVAKALKVMLDAPVTSVASTFHLAGPAIKTGNEILDLVSLLTMKPMNKAVEVPKSVALAFAKLVNKAIWWPTVSPDEIERKYINDAGIEALEPLDTSAYPDGWAPSQQSSIIPGVDGEPVKTFADLAISPDHIEEWAIRYVRRYRSSATYDMPVELGHFKNPKPYHTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSL2</accession>
    <name>K1VSL2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSL2"/>
    <dbReference type="eggNOG" id="ENOG502TM3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797808_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSL2"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="144" mass="15576" checksum="6A30298B73A74DEA" modified="2012-11-28" version="1">MVTTRSTESSTSSSTTPEPVGVPPVRRLSEPQVAEKEQTSVVADEQADMPAGVVGDIIKSIWEPGANATVVIAMNVSFFFLIMVLVGLGAMTNWMKEVVFLLATSVLLWGAMMHKIQSNPENMPIKDPLLDTSDAPQSETKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUL2</accession>
    <name>K1VUL2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000262">
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            <dbReference type="EMBL" id="EKD03202.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
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    </evidence>
    <sequence length="530" mass="58420" checksum="74975E05856EC8CD" modified="2012-11-28" version="1">MASLLDQLDHDYDGAETREVSPPSPLVDQPCSAVMDSGPSLVETSTGGAGDDSGIDLDTDGDSPMTTDPPTPGPSTDDNRNTLSADDAPVPPTESPSDDSEEGSESDAESSLNSPTVVLDQLSDTLRECARRDAELEGARREIDQRQVELRGKEGQIARRDGEIEKLTRELQLKSEALAQKEVELVQKNEEVETLRKELEAEKLLAKESNQSSSSSTKASTDQSCTSQDNRKDIGRELKSLRKAHRKLTAQIAVQYKMIASLRALVEEADKRYGNLYPMEKAIVILSAVYGEKLRGQPTIMNRFRRFMAGSYPSNIDKRLNVSIADLKAALEPLEQYLGKAVGQRNTVAHPSNDMKHFLQWDLDRIAARGTLGDIALHRTLVECAKSHPYGHRAGQHSARVEEVEREKRAPPVFYVEDSDEEDIREIVESASMRRSAPVSEASSLEEGEIDERKRKGKGKRGTKRKAPTVSSKEDEAASESDRERRVGPTCATAGAGGESIENRTLPQAEQQGRRRERRESFLAPGRTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVD2</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="EKD00738.1"/>
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            <begin position="100"/>
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    </evidence>
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    </evidence>
    <sequence length="376" mass="40021" checksum="E5A7A04C8915AEE9" modified="2012-11-28" version="1">MPPQPIVFASPADPAVGLKTKSSGFVSFSVAPPREPTPPPAPVLTFNQRRKSAVVVPSTASERLSSKMRPLNVTIVARCLVRPKVPSPPPTNKKRSSHQTPAASPTPSIPATGPAVHPYNRLHDLANTRSTIPSPQELLRAERAEEEKARQKKENAAAARAAAALARRRKALRSSRGTRGSSTVATPTPTPMIPPIQRAVAAQRARSAEAAAAEAHAAEAAQYKLPTTEPEDGGDTPTPRTLKRTRSSGLAPVSVGGNGVVNVNSPLRAVTSADDDKDKTEVDGALDETSAPRKRSRLAESVPPTRASRRGSTSPAGSASSLPEASPRKSGESSPKDSEDATSMRRVQSETQTQPMVRERSRRETQVPARMRDYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>K1VVJ6_TRIAC</name>
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="241"/>
            <end position="284"/>
        </location>
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            <begin position="241"/>
            <end position="250"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EKD04561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="321" mass="35117" checksum="D6F78E1B7854C1C5" modified="2012-11-28" version="1">MVAIGPRADPPAKRTPAERERFVGGDLDLSGCLVAEHAVEILPATLPEPAPLLFPYTFWIARPRSLATDPWTAHLSLPTTTFGPTSVIPVSLRLVCPPTYHAIALTLSLVREEMVMTRVGPGSSSQNNWTTVALTRRLLRPSGGEARAFVPLDLRGAQLAPSSSIEVGPADKMEEDDDEYLWTSVSSNAGLKVKCEYRLCVQFEFGTGSKHIFVPVVIGSVGEPRDAVRQYEWSELYFPPTSQSSPTLTTHNHQHAHEQTPTRRRAGNGSLHLVGDGEHEHEPSPILIWGTEEGSEDGWLVPPPSYGEALDVVPYVYDPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVN2</accession>
    <name>K1VVN2_TRIAC</name>
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        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
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            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502RBBR">
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    <dbReference type="InParanoid" id="K1VVN2"/>
    <dbReference type="OrthoDB" id="2413468at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1690"/>
            <end position="1699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1723" mass="184320" checksum="629F109AAD405C10" modified="2012-11-28" version="1">MLFASSSILPETQSPPSARTRTPLSPIDTTTLTPSPALSDYGPATLPDPSTLAKRRSTGASEALQYYWSSSAGGRSESFSSSLGTLASPLETSSSHTVLSSPYSISPNPLLHDGKSHSQMSFQEVIVGGESPKGTRGLQLVAEPDSTDDLNTTMQATSMPSNRPTPPPGSSQPPPSAYNAHSASSTLTSTSRRSLPMIPDAGITPHGAQNTSHPTHTMHSHHQPPQRLPHLPSPSPSPQPPSASQMTVDSGSDTIRSTSTRRKRPPLPPIPTSTPQTSSPASSYSSHSHRRLPSRPPSRPDSESGESRYSVDDSPAPIPPSLVRRDTAIQDELARLHSHRKGMVDMNGDIDVLLDPTFDEWAHQGGGNWNKAQSGSAASTIAEKLVTPTQEMANERGDRPHVAVNTDLREWGKTPSPRSADSGEKTPQGSTEVLVKPSPVSSNNSSKGRLSVRPTGGSAPGSTPGSDGPDSRRSTPSQASGSSRNANGGRQERPRRLSASPQEDPETPHSAPAYKTSFGDLRLPGRPASLLPAAKVDPPRRSQSLDKPEVLMSINQQQQQQQRQQSPSPQLPPRRSPDPPPRSELRQPNLSAVQESSTVFTASPTSTTPVEPVTSTSYNSTAPYRTTTLPTIINTPHTPVTSPRSSQQLRSKTDPSPGGDARSSSQMANSSTIQDLTHVVDNAVDEIGLINSQDTPPPLLSEPEKSTPSRPRSDLATSSLPPRTSSSMSSGDGASLSPTSAQFPGARPPMHVHSSSSNSAVGLGLMSSMGVSSALAGTQRSAINVGQSAISVGQNVGRHVRKASSILSMRSSSYTLSPTNATFQNQQQQPPVKSLPFAIMYGNIKALKTPGERARAYQQHIEGLARADSGLREWCSNVRNAPRQNVTKARVGLGIRDPAGAPRGLTIGEPTPRNVSGASEFPMRSDATRANEIRVPTVETTDNSTTVPLNNLPYPQLASVKGSGSMQSLASIPAPPTPAKNRSGGGLLSALRLKKEKENTSLGPPTNLLANGSNGKVARSYTSSSTSLGRASIDSPDGPRAPHSPSPHGPRPGPVTRTSYDSSRSSLDSAGLLGRPSSNNKAGSVNAPHGLSPLSRDDGVNEEDVRYMLEMLPHAERSTIRQYLERYGDTSYAMTYELDGSTGLWKEVAMLSRWSIAVDCWFWQDRRRRPTPTPRLRIVGRPFVRIPPETLANLPRLGSLRLKAKAHSWLRRPSSAGSASGSGSPAHSREASAVSHVSNLVSHSRQASTLSQVSSFFSISSRSRSKTSSQAPSLSSSHSREPSVASSHTTRAPSPVTPTAAGFPSDVAATTPAPPVTPAADAAVPTQPTADIEATPTPQAPAASAADDRPHPAPSKPSATSLHSVAESAKSETMSHNSSDSSAQDFLQCAYPRQSQNEVKQDPAWTEGDFELVSADGVRFRVPSYYMYASSEVFREFGQMSPSPGKQRLVLTEDFETSVIIGLYLEFVVHATFLVPGDGTTLESLVTVKRLVLFLRKYACDGVLKLLLLTIRECIKQPSSVSPLVGFIAGAIAEDAYTCSSSLDVGDWTWSMMNIPGSGLGSANVFDPHHMPVNVWQMIPGMYTWALTTAWKGDPAPRRQDSAMSMSSLGSLRYGYSSHREGHGREGSRIGGDSRMGGDSRMDSRMDSRMDSRMGDSRMDSRMGERERMDRVGDRVEEMRDMGSVHGSHRREGSRVDSRRSHRSASRQEPDVQRKVYAWQQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYA0</accession>
    <name>K1VYA0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clathrin heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYA0"/>
    <dbReference type="STRING" id="1220162.K1VYA0"/>
    <dbReference type="eggNOG" id="KOG0985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110377_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYA0"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012331">
        <property type="entry name" value="Clathrin_H-chain_linker"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="CHCR" evidence="1">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="218" mass="24727" checksum="E905C1663CA2CC33" modified="2012-11-28" version="1">MIMEQYQRYLQSAQYNEAAKIAANSPRGILRTPQTIETFKSLPNVPGSLSPILQYFGILLEKGELNKYESLELARPVIQQGKKQLLEKWLKENKLECSEELGDMVRTVDMNLALSVYLRANVPNKVVACFAELNQFDKIVLYSKKVGYTPDYAQLLQHLVRINPDKGAEFATQLVNDENGPLVDLDRVVDIFMAQNMVQQVTSFLLDALKDNKPEQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYC3</accession>
    <name>K1VYC3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYC3"/>
    <dbReference type="eggNOG" id="ENOG502RE71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562592_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYC3"/>
    <dbReference type="OMA" id="MEIATQS"/>
    <dbReference type="OrthoDB" id="2564914at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="394" mass="43280" checksum="B5900A744F857C40" modified="2012-11-28" version="1">MAPSPVRDKDSAAAEPMIDPELADLPPPPHHSSNGSNGSTRLPGEPTSITESIASAPNPHTTDFSPLPFTQDESQIPVVDDEPGSPTARLLRALAPPNAAQPDPKWPPPPPNASVNLFIGRALLSNGNDNWPLKPNDIVNWIRKHYPEEWDGDEGRCSAHRVRTYLARKGADMYYEKLNQGCIAGWRIRQNHLWRFENGGFQGRGMKQEEAMAQQAKENEAMATAVHKAAAAAALAQGHPGIKVSMSSSGLNESANKRRKPNGQARRKNEKKKPEEFDYSTYQATPTYEADSAALQSLEQVGESSTQPAQQQQQTTEEQNLDASQLQQAMAAANAVAGVGSVGQMDELEMGMQLPIEMQMHSESHDDREYYDGNYAQGYGEYNQQQYGDGYQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYD0</accession>
    <name>K1VYD0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">A1Q2_01114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYD0"/>
    <dbReference type="FunCoup" id="K1VYD0">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYD0"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="InParanoid" id="K1VYD0"/>
    <dbReference type="OMA" id="MPILASC"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="397" mass="43705" checksum="762E98EB21CE210F" modified="2012-11-28" version="1">MHLRLASHFGRHSRNFLTHHLLTVVSQHIDLLEKERSRLPIIIMRLTEIATLPGHEDAAWGVSFNPQRNLLASCGTDRTIRLYTYTTSSGSPEFQFHTSVPTGHRRTIRAIDWHPTGSTLASASFDSTVCLWEDEDAEGQWECVTTLEGHENECKSVGFSSDGALIASCSRDRSVWVWEVGEELECIAVMMDHSADVKAVAWHPVEEKLKPSAAKKEIPTLLADMRSEVERNEDELEVPPLQEPETVWCLAWSPDGKYLASGGDGGGIRIWRRKPGTSGLSSEFEETLHVGAHAGPVYAIDFLAPTDAMKSAAKDGSVALLASTGGDGRIIVWNASNEDEAECEDVPRLRLEPVAVVRDAHGVSDVNSLKWNKKEGQEGVLASCADDGSVKVWKFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYI0</accession>
    <name>K1VYI0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYI0"/>
    <dbReference type="STRING" id="1220162.K1VYI0"/>
    <dbReference type="eggNOG" id="ENOG502QSMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008599_2_0_1"/>
    <dbReference type="InParanoid" id="K1VYI0"/>
    <dbReference type="OMA" id="PEGTGYF"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="368"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="708" mass="78976" checksum="3749068C72C639B8" modified="2012-11-28" version="1">MGDTPQEEPAPVIKISCVECRRLKRKCKRYDKTCVFPEAENPRRGKKYLAEVKERVAKLERLLAEHAPQVSLDDLDIYLAEVKERVAKLERLLAEHAPQVSLDDLGGPLSPAADVKDEPDLPHKPPHGAKDAGGGSGSVSSSPVSRFQDYRQPPTPPAAAKPRPERKPESLRDNRIGVVEAHEKQPKKASGYEWNERVSAAENDGTACLSVEPNGEGYLGFAAGATLLRILQGAAGRQGGLDLSVSPRSEPEPPLGWAPTHGETQRWVDAYFRHYHSQYPIVHEPTFRAQLSEVIPQPPAAQWMLLMNTVIGLGAFTAGAPMYAVDYFLEQASSVISVDLLETGSLVLVQAYTLLSNLAQKRNKPNAGSTYLGIAVRMAIGLGLHRELPMWNIPPFEREVRRRVWWVLYIFDSGAAITFGRPIADVRMVHNVPDRDFTRKSAHVPAASRGATVYSSLIWQSHFCMIGNKCYDRVIASPPPTAEECLELDQELREWHNDVPNWMTRTATPDMFDDTPWLYFSAHKLYWRYCNLRIILHRRPFLDRALKPQSIADMTSPTTLDHGLAMECLQAALDTITDIHQFMLNGEHTRLEVWYALHFLFQACFVPLIAMWTDPASAERPLWAEKVREARETMARAQGDPLAERCMAIMDQVTPSDVVPGGVGPPVAQIQDIFSANLWQGTEFPGELIPFADLATIMSVWPAGGNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ98</accession>
    <name>K1VZ98_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ98"/>
    <dbReference type="HOGENOM" id="CLU_033753_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ98"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="465" mass="51917" checksum="7E5D706B9D0B4184" modified="2012-11-28" version="1">MSLCSPDANYEQTTGTFADATPYDSTPLSSRNEAHYLAQHLAHRCNDDLYPADVHFLDPWENLLNLPFPKRSWHSGLQRAMPLKCLTVDGRPALRSIKLARPLDPRLQRRRSTRRFERWILKHARTPELLWTASPAPNAPMTATASGSVRGWIDLGREAILQSVIYAALTYQVTGAALGLCVFRASFGRMFALNDRVIAMEDIRSPSERETMGRVPHVLDADEFSHLAVRMKDDTIEERLPFTFLSEEEGTNDAQLEALSNWTHAAYRLMLKQPRNGRFSRLPRVKSDLVEELLARVDAAKPGASPMSRPSTGKRKSPSSSPCDSATKCRRLEPPRHEWAWETEAESLLAEVTDMGYDGDDEGFASESDLGEGANETEPEHSEPEDQIMDIDDSPIEMPEAVIDHETNAYLGARYMMTPKGRGPSLSVYAKIVRALDMAILFVSLAEMSRLIADLNDDHVAGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZG0</accession>
    <name>K1VZG0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZG0"/>
    <dbReference type="FunCoup" id="K1VZG0">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZG0"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_1_1_1"/>
    <dbReference type="InParanoid" id="K1VZG0"/>
    <dbReference type="OMA" id="MIRASEY"/>
    <dbReference type="OrthoDB" id="2579858at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="213"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="582" mass="64858" checksum="EBF1B2731BB9DA0F" modified="2012-11-28" version="1">MLRSIRPTHLASVRVRPQLQLHTTSRITSPKSSPSNNAPVDTTAHSTSSTAAAETMRDAFTSLRAHWDSARRHARGHPRLAKGATGGALALAGLAYFLSGDDGKNDPMLGRPNPADVDALSRVPLSKLVVYAFCSSPLLIEWSEPLFKTVRQVPIIGYFVDDFARRTFFRQFFGEETPRLAALNVWAPLRAEHVGVLTAYNVEAENYDSILSHATIRECVEGTLDAIRKVGTFGLANSPPSAAEAGDTRCWVRTKVSGLLPDPQIMIRASEYIVHNRQGAVPYPGVPEDGDFDRLMHGDGLSVEDRRALKGLFEELRQFMRQGQKYGVRVILDAEQSWYQPAVDVMTEELMREFNSGNGPAIVCASTQGYLRRNTALLKSQFKRAQRDGYKYIYKQVRGAYMPYERARWKEKGFAGPPPVWDTKEETDATYDTAMRMGLKAIKERQEDGSKPDVAVIFATHNEVSVDTAIQYLEDYGMGTRQPDGSLLIDPFVANRVAFAQIYGMKDNLTNRTAASVKTEDGLPVVCKSAVYGTLEHALPNLSRRAAENKTVMEGRGGAIAERRRIGRELCRRYVPFYRSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0S5</accession>
    <name>K1W0S5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0S5"/>
    <dbReference type="HOGENOM" id="CLU_1031300_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0S5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="265" mass="29181" checksum="1ACEA7EBF3850B23" modified="2012-11-28" version="1">MSSSLSYRTLEPSDVAQDPNIMPVPYNESDPMRDWTDEYFWSKDLPADNIVCTVGDGTDSITTSQCCPPAIGIYSPNGGCRMSNTAQNSAYFHNCTLQLSLEEKPNTTAARVNATCVPFETYLNVTREQRRDEIERRTYDTLKGKARTFMQSIPVCSSVGWPERFNYTGKCCDKLGGDHTMTQGGVLKSDRSAHSLMDCYSPKNDSKFPAKFTQCLDDFGTWAVCAESRWKTDNGETDSSSAPDTTMTRMGAGLLVAGAALALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0W7</accession>
    <name>K1W0W7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00222</name>
        <name evidence="2" type="ORF">A1Q2_00223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0W7"/>
    <dbReference type="STRING" id="1220162.K1W0W7"/>
    <dbReference type="eggNOG" id="KOG1107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135248_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0W7"/>
    <dbReference type="OMA" id="FMITINF"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19300" checksum="6AB04EB4BE908A74" modified="2012-11-28" version="1">MAVPEDPKILADALNVVKVQTVQLKRYLELDEIMEALKAASTMLSELRTSSLSPKQYYELYMSVFDSLRHLSSYLYEAHIDGRHHLADLYELVQYAGNIVPRLYLMITVGSVYMSIQDAPVREIMKDMLEMSRGVQHPTRGLFLRHYLSGQTRDFLPVGNVDGTRSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1W109</accession>
    <name>K1W109_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Deadenylation-dependent decapping-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W109"/>
    <dbReference type="STRING" id="1220162.K1W109"/>
    <dbReference type="eggNOG" id="KOG2937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_329551_0_0_1"/>
    <dbReference type="InParanoid" id="K1W109"/>
    <dbReference type="OMA" id="DEADHVC"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="122"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="709"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD05497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="770" mass="84838" checksum="144D42C52AA54501" modified="2012-11-28" version="1">MSHYAPGPTPPITASPSQPPLEDEDGGEDNIFRDMTFEEVLEDLNARFLVNLPEEEMSLVRVYWQAEQAHWFYEDYLRPLNPLLPSLGQRQFTHLIIASSPLYADTDIDYDAVWEEYCAYKKMVPCCGGILINDTADKVLMVRGWKSNAGWCFPRGKINSEESDVSCAIREVEEETGFDLSGLINEDDFIKTQVNAQEITMFIVPGIDESTVFETQTRKEIGAIEWVPFSDLPTWTHKKGPKRTGGKGQKRFYNVTPFVGPLKKWLSKHGYNPHPPRRKEKTGPVGRELKPFAFDDAPAQKAHPTTALDHLFAKFIEKDETAVALESDNARTLDRLFGSLEVSDGSHQAQTQQQRSDDDALAKLLSGIGHVSAPPPAPQLQPSLPEKQTKFLSVLNQKAPAPLTPPRSTHQTNLLSMLASPPKVAQHDPTPPPASHQGNLLNMLSSGPQQPHQQAPPEDQMARQRALLEASFGGVGEQTAATPPPRAVSASSMMSPMPPLPPAEGGWYGQQESALHGPPGTPGYQRLPMPGSPRGMPGSPVRGGYPQNQLRQTALHNSQRYPAPPQPQPQPQAYPQPPQPQQAYQQPPPQQYQQPPQSYQQPPQPPQPANDHQRALLGALFNGRQAPPHMQQPPVPQQQMPQQYNGYNQQQYPQQVPQGAPQVAPGYAPYPSPGAPNAPPQMNPQMGYGYNTYPQQPPSQPQHPPQPQQPQQQPPQQQQQQHQSMPQPQPAPAQSVQQPAVGPPNPPSPSVHQPVPRPPVGGGLLGLMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1X0</accession>
    <name>K1W1X0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1X0"/>
    <dbReference type="STRING" id="1220162.K1W1X0"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="InParanoid" id="K1W1X0"/>
    <dbReference type="OMA" id="SCHSHGE"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="360" mass="38581" checksum="2898BC40CF89AC0E" modified="2012-11-28" version="1">MSTTTTASTPSPRPSSPRRRTVSDNVCCTPTDQRESVIPWRRANPSHGPHCPEAHAQSACGTVVLGSYNMGMHIASIFIVLVTSFFGIMLPTVAGWFKGPSVADLDSASVGREYGVWGCVFFFARHIGTGIIISTAFIHLLYHGFLMFSDPCLGTLHFPPTAPAIALAGAFITFLFDFVAAWRQGVQDDRDKEASEACNISIETAQRRKAAWQVILLEAGIIFHSVMIGVTLGADSSSAWTTLLLVIIFHQLFEGAALGARIASLHWQTKLHTILQILAFMLITPIGIAIGIGVRQSFSANGTAALVSIGILDSTSAGILLLASDFVDGPLKNASGFRVFMAFASLLTGLVVMSILGRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W275</accession>
    <name>K1W275_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has a role in mitochondrial fission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W275"/>
    <dbReference type="FunCoup" id="K1W275">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W275"/>
    <dbReference type="eggNOG" id="KOG3364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="InParanoid" id="K1W275"/>
    <dbReference type="OMA" id="DGYIGMG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="137" mass="15433" checksum="47C76DB010DE392D" modified="2012-11-28" version="1">MASIATDLPYAAEAETSLSYDELEVLRNQYYKEIESGHVTTQSKFNYEIYSASPSHRRECTYYIAVGYYKLRNYTYARKFNDLLLAVEPENMQAQSLRQLIDRAVARDGYIGMGILAGATAITGIVAAALIKRATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2R0</accession>
    <name>K1W2R0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2R0"/>
    <dbReference type="eggNOG" id="ENOG502RE1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_4_0_1"/>
    <dbReference type="InParanoid" id="K1W2R0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="326" mass="34666" checksum="EFD3A8F70BF0AC8D" modified="2012-11-28" version="1">MAPAPAFNRQHATGSVLGLATGEALALPYVSSPEKVDKGVTMISGGDWSEGEWGPSTAMALAVLSAMNEAVIYNREKWADYLAVRWVEWAHSEGKGLDSRTRDLLRSVSREEASEEALASRAKASGGAGALPVAHVAPLALLFLGEDQEADLAKAADRLARMTHPEEDAREAAVLVALMMQQAARYGSVSIEEQIKYLPTGSQDKWEQLLKEGGDAASFNSIHVKSSDANKASVAVLQSAVAAFRSRSAVENVLIQAVRSTANAHVAAVAGALTGGDEGSRELPATWTSKLHGENLNGRGSAVDAITKDVENVVNRTYQWDPYKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W642</accession>
    <name>K1W642_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000417">
        <property type="protein sequence ID" value="EKC97238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W642"/>
    <dbReference type="HOGENOM" id="CLU_769845_0_0_1"/>
    <dbReference type="InParanoid" id="K1W642"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38050" checksum="918D654FFE80D3C8" modified="2012-11-28" version="1">MVMIDHTFFPHIIDALWARMDFDSVLAARTTSKEWLRRGNKRLRRHMLLQPPDQYDESSSDDVSTVIKYGYMEDNYYLTFLLLSTKDTTYEAFDSQNIRPRRLSETDIDTLRHPPAPGTLCEVLQDVEVLDVRFSPELYQSFVSYDVLLWHAQKRAIIRVNLMQHTPGVVPETTVGGMGGTQVYFVHLQSSIDIRALVPETVILNLNCQEDSPGFSYRHSRLEVSPGGLDKSRVVLIIQNGFPSRYFRDEHVMFLWSWTRIDCRTVDVTVVASEDLYDTEADLRIFKQRICQQVLGTRGRTSIAPPRILTPAEYKAEVGAEKYKIYTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6D4</accession>
    <name>K1W6D4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_08266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6D4"/>
    <dbReference type="eggNOG" id="ENOG502S27S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037802_1_1_1"/>
    <dbReference type="InParanoid" id="K1W6D4"/>
    <dbReference type="OMA" id="CYTPVYP"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC97343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="37960" checksum="2BF73CEC425602BD" modified="2012-11-28" version="1">MFTPVQTFLGGLLLHLSTQGLLEDTGRVFGISGIVSEAAFGDKARWRWAVIAGLVAGPALVHTVGIAPYVPDPTAWTWTAMSPARFALAGGLIGFGSKMGSGCTSGHMLCGVSRLSPRSIVATAVFFMTAVLTAKFFPAPVNVPPPAYQLAPFSGQGTLALLGTVLGFVAAKKLIDRLVPRCVKPTVPAPDAAECERITESPAGLATYLWAGLSFGVGLVMSGMISSLKVLGFLRLPPPLDSFDPSLGMVMLGGVLPNALSYFGMMKESNGHPKPRFGWEQWRVPTRKDINPRLIAGAAIFGVGWGLCGVCPGPAISTLGEIAVAAANGVSLDKLQPGFTAWGAYIANMLAGMYAVKLVDSVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6G2</accession>
    <name>K1W6G2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000223">
        <property type="protein sequence ID" value="EKD04508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6G2"/>
    <dbReference type="FunCoup" id="K1W6G2">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W6G2"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_0_4_1"/>
    <dbReference type="InParanoid" id="K1W6G2"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="145"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="471" mass="51637" checksum="A757D2C0639A98DF" modified="2012-11-28" version="1">MTTHLARTAFTYPLQTPSWFAGHMAKSLNQLPALLEEVDLVLEARDARLPLTSVNPAFDNVLEHVWGHSGAGPDRHGKGKEKLVVYTKRDLAEQRYEAPLRRAFQNLTGQRVQFADSTVDSNVRAVLKAAVNIAKERGETLTDLKVLVVGMPNVGKSSLLNALRRVGVKKGKAFTTGATPGVTRKLTGTVKVYEKPNVYVFDTPGVMVPYLGKGEVGAERGLKLALTAGIKTGLFEEEVVADYLLYKMNLRLAAEEMVGSDHRHAPYTQFLGLQATAASDDLNEFLESLAARLGGLKKGGALDTESALTYLLRVFREGKLGPWTLDDLDGAEEAYIEKYGEERAPEANMRYSELGAVGVTPATDLIEEPPIDLGDGPEPPASTPIVQAAVQNVEAEGGVTPVHLSLDQRVMLSVSRFMDQLAEQKADEEAGRNRSPTQVKKQERREKLEERRKKSEAKRQRQKAALASARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1W718</accession>
    <name>K1W718_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000205">
        <property type="protein sequence ID" value="EKD04663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W718"/>
    <dbReference type="HOGENOM" id="CLU_2361230_0_0_1"/>
    <dbReference type="InParanoid" id="K1W718"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="96" mass="9981" checksum="F0634A04D9793AF7" modified="2012-11-28" version="1">MLAAPSPASASAPSLSPAASTLDSTLFSGSPKLPQVYGAEAVPALDFMYAEQLWPKEPGAADFALDAWFPFPPLGELSSAVDELTPDSDIHDSFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7A6</accession>
    <name>K1W7A6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7A6"/>
    <dbReference type="HOGENOM" id="CLU_2656211_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7A6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="76" mass="8041" checksum="E7D0DB848F2B9FE1" modified="2012-11-28" version="1">MAFASLADELDLDGPGYDYDDEYEYDRGVGVSLADELLDGPDDLGRGGASKLTPEPGLGSLAAELDAPTLDYEAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7L0</accession>
    <name>K1W7L0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7L0"/>
    <dbReference type="HOGENOM" id="CLU_660882_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7L0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="360" mass="39720" checksum="5536CB1E7407F66B" modified="2012-11-28" version="1">MATPKKSTLAQIFDFDKDVPRQRHRFGFNFTPPPPEKAVSEGSGGDDEVPELKVFTGDEKVEEEVHMRDEGEEHREGEQSDEGDELMSSVASADGSLGPSSPPKDAFVTKADTPPRLYVTVPLRGVTPTMAPPSNLKPPPLQGKSLKIEHHLEVRTPSKVKFTVQSPEADEPASVDPPSSDVHQPTAKLAALQAERLTIAQIKKQVKNEKSKAKLLAMPRRVSPEKKRAWLKKTNGDRGRAATLSKRSETKPRTPAARHSSPAASSEHATTLSNVVAFMEAHPALVAPPITLDTDLSLVARLTPVLINEVREKMDTLRRHLREAEDAGEDLEPYMAQWKRWVEEHNAFVLHDKLRGPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7Y6</accession>
    <name>K1W7Y6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7Y6"/>
    <dbReference type="STRING" id="1220162.K1W7Y6"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_706343_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7Y6"/>
    <dbReference type="OMA" id="EMDEDAM"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="391" mass="41596" checksum="7FF13E96A08F0050" modified="2012-11-28" version="1">MAQKRGVHNTLASMILGEIPAFPLPPLPPITDPVLSRTALTHPSLHQNHRRPFDLEGADRPEDYEKLEHVGDALLGSVVTLLLHDLHPDLDPGAATSLLVSNETLAELCQRYHLHDNFIGAPAALPTIRAAVGTRACLFEAYIAAVYYDFLTSERPGLYPSGSQSTAPSITGATIGSDVGDDGDTAFGDDGAEERSQTPTPTEPPETPTGLEDLSISGNKTPPARPGSAAPSATSSAAVPSAYMHVASDAELPPLVPRYKRTRGMAVDYLESWLRPLFTPVAEVGLQSMRAKWREYQASGAAEDGDLDARAIGALSALNQFTNAKWACMPRYKDAGATESGGWKFEGEVTSPEGKTYTATAVRPNKKSAQTVLAYKIGKAMQADGHNVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W990</accession>
    <name>K1W990_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ER membrane localized phosphoryltransferase, Gpi13p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000092">
        <property type="protein sequence ID" value="EKD05393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W990"/>
    <dbReference type="FunCoup" id="K1W990">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W990"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004298_1_1_1"/>
    <dbReference type="InParanoid" id="K1W990"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="790"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="854"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109562" checksum="7E9D99C06B29F1E9" modified="2012-11-28" version="1">MAEQREKEPVVQAAARRVASRWINGLGRVTLALLALGTVAVIHLVGLLIFTNGFLLTRLSIPAVSPAYNATNPPPVPPSFEKAVIVIIDALRTDFISPNYPTLKSEYHHGVLSLPTELSEKDPSHSLIFNSYSDPPTTTMQRIKGITTGSLPTFIDAGANFASTAIEEDSLVQQLLAVNKSIAFMGDDTWMGLFPDKFKHAHPYDSFNVEDLHTVDNGVIEHIFPYLAPENRTEWDVLIGHFLGVDHVGHRVGPERETMRQKLKQMDDVLRDVVDKLDDKTLLVVLGDHGMNPKGDHGGDSDLETAAALWMYSKGPALTGPAINDFDWPTYTFPGSTKPIRHVNQIDLVPTLALLLGIPIPYNNIGAPIPEPFSSSLGTLAAASGATAQQIERYVKAYGNREVATNLLRLRRNAADDSLEGAIKHNYAVCATALSSLRALWAQFSVTHIVVGLGVLALGVLASLAMYLGVRNSGPRWDAYVRFALDTALTAGAGVGSVAGTLAGVYTRKPAVALQVFFVAMAVVESVVLAAPLFTGHIRSITWNLGKSVGPLVLLLHCLSFASNSFIMWEDRMVLFLLVTVLVVHMAQSFTAPTASQRLRILLFALVFAVIARLLSLVTVCREEQQPYCQVTFYSQGAGQPNWALAFAFLSAVMFFPRFIATVLDWSKSYAGPAPLFVAVFWRVVIVVNTMYWVLDFCETWDGLNPDRIPLAKMLKQWAARLSLGAVLGALPYLWWGSGLCIRAEKETDQATGEEAVKVYGAGNAWGASYLLWLLVPFALVHLVSPTPGQMVLIGMLTALLMHLELVDTQRDAAVMKRTFTTGQKGMQATFELQGAGEGLIVRPSFSDVVPLALLATLAFFATGHQAVLATIQWKSAFVGFDTVTYPWSPALVVLNTWGPFLLAALAVPLLAIWNVSPRPNDTVPIVGHVLQVCLAFSTYFAAIALASATCAAWLRRHLMVWKVFAPRYMLAGITLLIVDIGLIAAVAVFGLTQQKVKRTFRSVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA56</accession>
    <name>K1WA56_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000061">
        <property type="protein sequence ID" value="EKD05633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA56"/>
    <dbReference type="STRING" id="1220162.K1WA56"/>
    <dbReference type="eggNOG" id="ENOG502S2KW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1020098_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA56"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="273" mass="30023" checksum="0F8365D17F63C259" modified="2012-11-28" version="1">MQLHGPVPLALKHRFYPFKGFVAPMFEAKGLRGMAMHHIMHRQHKQTYHFDEWTKYGVLPDPPAPESRHPSVSGPSFSEPFAPGSLPAASETSVPTSQESVAGSSVKSVETQGGGNAEYEMARRFLDMCHWGKGARIFTYVITRNGMMRFTETGPEFAIDLLSKHMMHADVDTYVAYSGEFFVRPRRRANGSAASSPTHSRETSATSVDTNGDEEEDVRNMLEPVPVCIDASSSGVEQSSDTPELEELVLLQLLGEGNGVVLGLRGNYCQLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WCF7</accession>
    <name>K1WCF7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WCF7"/>
    <dbReference type="HOGENOM" id="CLU_1143239_0_0_1"/>
    <dbReference type="InParanoid" id="K1WCF7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="218" mass="25417" checksum="9612FF0F0B8844C9" modified="2012-11-28" version="1">MSANGAQHDSRSNEDPGEVWRRRYSMGREDNEDTLWDQLSVRQYRMLNPWEYIDFDWMPAAGYPPLVLFGASDETCEVKCALAHVIWDEDVTTRTPDDVQRLEDVTADTPSTPLAPAIGQFSFKAVPGLKEWALADDGSGDDKMTWDRYCFHRVDYNKCNRDVVEFEKRIGKDLVECGGQKWATLAQDRRWDWLRDAHERREKLRVGQTPKKVKKEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDD5</accession>
    <name>K1WDD5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">A1Q2_06042</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDD5"/>
    <dbReference type="FunCoup" id="K1WDD5">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WDD5"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDD5"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EKC99623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="32284" checksum="960769EEE04F466D" modified="2012-11-28" version="1">MMRTTALRALPRGTVARQLSTSAASQFAQPSESTATPAAGTKPPQIKEFKIYRWNPDTPSEKPKLQSYKVDLNQCGPMMLDALIKNEMDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIDKDTSKPGKVYPLPHMYVVKDLVPDLTLFYKQYKSIQPWLKHDNPPKTEILQSQHDRKKLDGMYECILCACCSTSCPSYWWNQDQYLGPAVLMQAYRWIADSRDQATEERKEKLQNNMSLYRCHTILNCTRTCPKGLRPGSAIAFMKLEMATGKKASHGITEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEU0</accession>
    <name>K1WEU0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEU0"/>
    <dbReference type="HOGENOM" id="CLU_1180930_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEU0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852880" evidence="1">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="235" mass="25217" checksum="B4BEBBC505539A51" modified="2012-11-28" version="1">MTLLPILTLALAGTATAGHSRRSAGKKLEKINGCAFADTSCASEIEWTSPCCRAGNCHYDRLESGVCVPVVPDASTFDSGNCWVAEVSPRQTGFGSLEPGPLFDDAATNAHADEMNSLTYIAPTREWDSWALKHVTVGATAQTNFENEVQRNYAARMAYHAANDSTSVHKKQGIKQYEGPEWVHVATFNLGDCSSIPRGSIMTGSMRVAVEKKGEGTDVLRSVGGLLSSLAKQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFW4</accession>
    <name>K1WFW4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFW4"/>
    <dbReference type="STRING" id="1220162.K1WFW4"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_1_0_1"/>
    <dbReference type="InParanoid" id="K1WFW4"/>
    <dbReference type="OMA" id="MNGSFQI"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF20">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="8">
        <location>
            <begin position="64"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="8">
        <location>
            <begin position="239"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="460" mass="50610" checksum="633AC454532B2294" modified="2012-11-28" version="1">MSSSRYPTTTDEDAQSDNQAHDLLDDRRVKAIRPLIPPQILTEELPLTLRGAQTVLDGRRQVEAVVKGDDDRLLVVVGPCSVHDPEQALVYARQLADYAEKAKDDLLIVMRVYFEKPRTTVGWKGLINDPDMNGTYQINRGLKMARKLLLDVTELGLPTAGEFLGEYMRRPLGRRASCAIAMCARVSTEKKRWRRSERKQGGKLRGKVLGRRNRRREGRRSLRKGRRPEQRKAKKADTIADVISPQFLADLSSWGAIGARTTESQVHRELASALSMSVGFKNGTDGSIGIAIDAMGAAAASHTFLSVTKQGLTAIVETEGNNSTHVILRGSTKGPNYSEKDVLEAGEKLKKAGLNPRIMVDCSHGNSNKQHARQIDVGRDIAAQLAGDGPTAQMIMGVMVESNINEGNQKIPPEGPKALKYGVSITDACISLEQTLPLLDELREGVRQRRRNVAAKRTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH27</accession>
    <name>K1WH27_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH27"/>
    <dbReference type="HOGENOM" id="CLU_672988_0_0_1"/>
    <dbReference type="InParanoid" id="K1WH27"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="409" mass="44591" checksum="286421E324EE57BA" modified="2012-11-28" version="1">MSVRTGSENGSGPDDSASESTGSSSSPIAIAGSSRHGSALLPDPPTPSPQRCTATSPYRTPPTSSSPPPTNHGDGPFTGLVFGVLPDQWEPEILMEAQRMIVLGGGKVRRPGARVHPPPELLLLPLIYEQRTPGGSLITPLPAGWNNLKFVVTPWIVSCHQLWRRIGYERPILLGLDPSIMTPSGPAVTTSTTALGYRHSAANLMEEMMRLRERHAAEVAALHEQLQLQQVELDKRRTSSAALAEEITENLKGFLRVELERQIQATDTDNFGRYAVKKPSSTNVKNDIDSLDQLSLLPPTPETAGCSRLSKTCENRMPRAPTSADPSPTSLEDKSVALTADISAFFAQTESCYQTSSTSSVDRAERTLSGIRRILFPSQPSKKRASESEESPQPIKKLKSRPYWYRIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJK3</accession>
    <name>K1WJK3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJK3"/>
    <dbReference type="STRING" id="1220162.K1WJK3"/>
    <dbReference type="eggNOG" id="ENOG502RDG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031875_1_1_1"/>
    <dbReference type="InParanoid" id="K1WJK3"/>
    <dbReference type="OMA" id="CKMLHTE"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="42"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="438" mass="51299" checksum="98D9FBE5AE84C292" modified="2012-11-28" version="1">MENFITGYPGHEHEMRRALRAVLGPEKYEYFFERFLTYFFDEADAAFFASLGLNCLRLPVNYRHFEDDMNPRVFKEEGLRHLDRVVDLCARHGIYTIIDLHAAPGGQNVDWHSDSGIAKALFWDHKDFQDRTVLIWEKLAQHYKGNPWVAGYNPLNEPTDVEHTRLLAFYERVEKAIRAIDAEHILFLDGNTFGADFSRFGKPLPNSVYACHDYSNYGFPNPPEPFTRSEKQIATLERQFERKIKYMREIGGPVWNGEFGPVYASPEDGDDYEKTNDERYAVLEEQLKIYARVNASWSIWLYKDIGFQGMVYVDPETPYMKLLKPFLEKKKQTAVDAWGCDDTPVRDVFVPMERWLTESAPGIEKLYPPMWRAHKHLFRRVRNCLLGEVMSDEYAEYFRDKTTEELDELAKSFALANCQKRGRLNHILTEDGKREVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNR1</accession>
    <name>K1WNR1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Import receptor subunit tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_03085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNR1"/>
    <dbReference type="FunCoup" id="K1WNR1">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WNR1"/>
    <dbReference type="eggNOG" id="KOG4111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094333_0_0_1"/>
    <dbReference type="InParanoid" id="K1WNR1"/>
    <dbReference type="OMA" id="LVWIVTT"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="17580" checksum="8BF6C4AE7CEF8591" modified="2012-11-28" version="1">MVLVEEVKEEIIVDRESDYETESEFSEDDAESVISEDDFDPSTETFADRVAALKDIVPPETRKSLANTAETIKSWSSSAYNLSGNIAWWVCTSAILVALPLALASENEAMITQQERELQMQSTGQQQHELRRLAEQRKVVRSAAAADVDLSYGTCGGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP21</accession>
    <name>K1WP21_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCA1-associated 2/ETP1 RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP21"/>
    <dbReference type="STRING" id="1220162.K1WP21"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921928_0_0_1"/>
    <dbReference type="InParanoid" id="K1WP21"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCA1-associated 2/ETP1 RRM" evidence="2">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="302" mass="33107" checksum="90EFFA9AD03947C3" modified="2012-11-28" version="1">MLTAHSDVYSIIIEVHPDNENPEQPGQDWRLGDISVDWVDLIREKSSDRAWQEDDQHQEEERIEKHPTVPGAMTKTTSKPSPRHRKKKRPESIDDLSLQPLLAHIAGPNPFEASSSSGVTHVGNGVVHLFKHAPPASLIARLEGQNGEGSSGPPDPEGWADENAEGGDGSLIAILAVPAWMRPADLIEFLGGWAGCLEGVRMIRWVTTIVPANQQRSNDPQPVNRTAQVQGSAAGVRLYGDLCWQGVLDTRAARDLSPHPRAPPRPAPLGRERHRRSRIPAKRVREPRQGAAEAAEGRAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQA6</accession>
    <name>K1WQA6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyroglutamyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQA6"/>
    <dbReference type="STRING" id="1220162.K1WQA6"/>
    <dbReference type="eggNOG" id="KOG4755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776559_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQA6"/>
    <dbReference type="OrthoDB" id="2595403at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="357" mass="38335" checksum="57A459290A23362F" modified="2012-11-28" version="1">MPPVLLCLEVDIGRNWWYIAASETRVESPVALGVALEVAWVLTAKMSSSGLWRPQRTCSATHARFGNSNILRSEASESCSREGADDGRRPGESGMGAADSTAISDKTSRHADRVTTTKPGSIPSSTPRLQQLHHPSHPDMIIITGFAPFGNLPDNPSRTCARMAVSLLNAEGIDAAFVEVPVEFDGAFPTVQNVVRDHKLGAGDGLICVGVAANRKSVSLETTARNIIDARIPDNAGKQPRNTKIAPDGPDTISTRLPIKAAIEQIKNAGIKVDFSDDAGEYVCNCLFYQIVNDADLKNHGVVTGFVHVPLEEAVKIDDQTNALIILAKEIEKEAHKKHRLPTDDQATNGKQVPLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQL0</accession>
    <name>K1WQL0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000259">
        <property type="protein sequence ID" value="EKD03334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQL0"/>
    <dbReference type="FunCoup" id="K1WQL0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQL0"/>
    <dbReference type="ESTHER" id="trias-j6f4x8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="K1WQL0"/>
    <dbReference type="OMA" id="NNWYPQF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005137307" description="Carboxylic ester hydrolase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="43"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="588" mass="64414" checksum="DC0BCB4B0984A1BF" modified="2012-11-28" version="1">MKVASTFIILASLLGSSFASPAPVVVSDGGMQGGLEERATTITVNVPAGSIVGTQEIWTENFNGIPYAETAQRLRKPVRRKDPLVNWDATKAAAACPQQIADSDDPNFIAQVLSTVSETSLFKKALKISEDCLTVNVIRPKGVKQGDNLPVLFWIYGGGFELGWSSMYDGSLLVKSGLDVGKPFVFVAVNYRVAGWGFMPGKQVKAEGIGNLGLLDQRMGLEWVADNIAAFGGDPDKVTIWGESAGAISVFDQMAAYDGNNLYNDKPLFRGAIMNSGSMVPVDPVDGSRGQRTYDAVVKKAGCDTAPDSLQCLRDLPLDKFTDAANSVPAILSYQSVSLEYLPRPDGVFMTDSPDNLVSNKKYAAVPMIIGDQEDEGTLFALFQSNTSATVESTTDYLQKVFFPQAPRNYIEDLVKSYGTGIEALNYGSPHRTGIFNEIYPGFKRLAALLGDAVFTLTRRIFLEKCTSLNPDVPAWSYLASYNYLTPIMGTFHGADILQVFYGILPNYASRNIHNYYLNFLYNLDPNNASGGDGSNRSKVKENWPRWDSNSRQLINFYAMYFKQITDDFRERSAAVLRTAYGALGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQU4</accession>
    <name>K1WQU4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000250">
        <property type="protein sequence ID" value="EKD03419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQU4"/>
    <dbReference type="eggNOG" id="ENOG502RBBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459415_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQU4"/>
    <dbReference type="OrthoDB" id="2574658at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="594" mass="64108" checksum="F3DD956711CEE9EE" modified="2012-11-28" version="1">MSAASSVQQPRHRRGSNSASMSNSSDSASLRSAAASWQASVRSGTSKTSKEKSGGLWSRRGSVAPKSLRSTRSRGSTRSGQREGSITSGSEQAFEMTAVPLGGRGKKKVVIENEAARQSRAKADAAMAKWRKWIVEEQPRAEFDNPLQPSRSMSITLGANAGPSSEYSPLRSMTPNAPPSALPAHLVSSPPGSSRQNWADTVGTVSSVNSYASASSSRNVPSTPSQLQHLPGVQDIYTTESVRQLRDVELAIDPAFYGQGTVNGRRLSTHPRMSERENPFHSIHALISRRGIRPFVLELVQALGAFIDAVWSVCHPGKACPWAGVPTISRRPSFAGALQQSKTWCSWTLAAVQEGKRQGFLNSPPTEKDVTFWNREVRYGLRDIDEAVNRRKDLGWAFGKTVIEGQYGDITASNVFAHDGVSAGNIARLLNDLEEVLWGDAIPAPSDLAYEHDPDFDPFSVYREGDELIGVEVPRQPELREAELRRVFGDFLPTQAIPPTSPVSPVPPGTRKSSGSAGRPSIPSSPVQEAGPSRQARGSLSGPSGDGMPDLDMSALGALQDLSLEEKLQLGRKRHQEYLERVRAETEGAKGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQV8</accession>
    <name>K1WQV8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQV8"/>
    <dbReference type="eggNOG" id="ENOG502RV8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718024_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQV8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42160" checksum="686446D30B8DBDFF" modified="2012-11-28" version="1">MSNDQNPGCGFASLPAELIADIIAFLSLSDIAQLLRVNSPLHEACIKAIYTQTQDVFESDNLFERNHTHARPPLDNAKYAQHVRCLDVRARPQACCNLPPFSLPNLDVLRLRFDTEFLECNRGCLIPEFVSTDVYKPKMLMIHTPTSFYGDAFPIDYVAEKIKTAELVLVVKCSAGCDMAVSKCTPVTARSVTIIIHVGSLQETFPAIQNLCTRLANLSCYPFYGHRLQHVRFVLAGIDLTSRCYDQLLISLQEHIRKCTHYKGDDAPGADATQAALFAGPLAGDLQEDAEPVSNLPPPAIEVCSLYDYCLLKSGQLVLSWEDIADHCDLAPDNELDDPKSIKDFIESYSYAGPARNTELPRAEDIQGLLALHMGQLVFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRP8</accession>
    <name>K1WRP8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_02000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRP8"/>
    <dbReference type="STRING" id="1220162.K1WRP8"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020346_4_0_1"/>
    <dbReference type="InParanoid" id="K1WRP8"/>
    <dbReference type="OMA" id="HYAFENA"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="13">
        <location>
            <begin position="419"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD03654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="698" mass="77623" checksum="FBFAEED54A43776B" modified="2012-11-28" version="1">MVYDPVRDCDIPSPAIQRRPSLWESPQASTQQPSYSPEPSPGVRPLSGPGMRSLLNDDAPGPSRRGSDLTAASSDYEEHGQAARPHLSKLLNDTPTINRRTSSSSSVHHHEPTASSPRLSSPTVGLHPGSLSRVSTQRSPLMPEARLSSPSSAVSTGHYDLPPAFGDRPSSRRSSFDVSSRSMPPPSEPIRHELTTPTSHSAPLRSPSMSASPGSHHIGLPSERPQPRGSRSNSGTSTSRPPPPTTWSPEPNHSRRASEEVPPSPSNASNGRRSPPPPPARTPYEPRHPSSSRTIRQPITQDELQRLRTEAAGNNPLRRKRRSAPSWSAPSPQRGSSIDASAEAGPSHPHSRGPSRRGSTASATSRPETVPQKRSSKDMEPVDDRAVQRRRQDYTGNAAEVASHYNARPEVGVEHREFSPIIGLKKFNNWIKSVLIGKFAYRERGRPGAKVLDLGAGKGGDLNKWKQARIDLYVAMDIAETSMDQARDRYNTMRGNKFEAHFYPFDCFSNPISEILPSGLKRANLYDNVSMQFCMHYAFETASKARMMIENVSRYLRPGGVFIGTIPNAEQLLSRLEEIPDGDELRFGNKCYEIAFDEKQHKGVYGHRYRFYLQDAVEDVPEYVVDWDNFVNLAREYGLELIYCKTFNDVLQEEQNDREFSQLLTRMGVVNQDGESAMDDDQWEAANIYMAFAFEKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU10</accession>
    <name>K1WU10_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU10"/>
    <dbReference type="HOGENOM" id="CLU_2639856_0_0_1"/>
    <dbReference type="InParanoid" id="K1WU10"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="77" mass="8439" checksum="30679F0F48784BBA" modified="2012-11-28" version="1">MGAAEAAALAHAEAAQRRKDPQPRPKEAPTKKDKKNLPPPPLQIRDEGRGAEYTRTGFLGEVSTSAMQVRSRESQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WU15</accession>
    <name>K1WU15_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WU15"/>
    <dbReference type="HOGENOM" id="CLU_422839_0_0_1"/>
    <dbReference type="InParanoid" id="K1WU15"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="648" mass="67297" checksum="B87AA7DAAC93D112" modified="2012-11-28" version="1">MVSHTPRTPFPDVPPSPPCPAKACSIPLPPSPTFPPVSARGSPPVFSPPSAQTARESGVSGTSEWDGATLVSSVSSEPRSSRSSLSESLSDSRPAASAVISGRAAPSVIEPDLPTLSGSAPLPDLPPRSSSLPDTQPAQPAQPAQPALPQRSSSLPALPPPAPMSKFGSTSIVTVTTPLQAIVEGREIASPSASTGLDPSLASYALGPLQVIEERTEPNTADTSLDTSLDTIDVSLLSNPFGEDEVVSGAAGGAGVKEQQEQQEQQEVEEEHEEHEADVTGATFGDTTLDSVYSQESRASSVYRRSEVLLRGVLGRGDGLRPPTSPAPAAAPDTVTPTPAGETELVGPEPASGVEGVRAGSGVAVGERGREEVEQTGKGEGKGELQGEKKGEAGRSKAQAAEAGEQQRDVSPLQPLAKREEEDLPGCSYDELFKSVNPVSLEEVRLEACGPRRAPSDDSALQCCADDADADSVLAESVLDAAEVDSIMAAAFNEADTPHTEAVATAEKDDNGDDGDSGAEADTEADPAQVTVRGSPTSKRASPKHTATPPATPRPKRSHVVHHRSTYALRSRRSLPDQSTHRPTQSSTQTAFQNLAHGLELLSQEMKAAGKATEARRRRIASAPVPGSEADGEMTDSEGDAEMDVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVJ4</accession>
    <name>K1WVJ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVJ4"/>
    <dbReference type="HOGENOM" id="CLU_1983129_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVJ4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="126" mass="13621" checksum="C25BBF5224AD8515" modified="2012-11-28" version="1">MVNAIAPRDGTAQGGEAPAGEEQKNAELDKVEAACKDTCKPVTTLFTDQKTKPCVSLPEDKLKEDANCRKVYCQALKDVLTCSKCQFRALGQDPESNSGASEYFKQVEEQEGAKWCKDTGVDLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1WVX8</accession>
    <name>K1WVX8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000180">
        <property type="protein sequence ID" value="EKD04974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WVX8"/>
    <dbReference type="STRING" id="1220162.K1WVX8"/>
    <dbReference type="HOGENOM" id="CLU_511099_0_0_1"/>
    <dbReference type="InParanoid" id="K1WVX8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34863">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34863:SF1">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="463"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="619" mass="69526" checksum="EB70724B079BE7F5" modified="2012-11-28" version="1">MVIPGSLDFGSIHASVDWKGQQYKVKIYPRLVHTIKSFNSRFQGAPLMTVAGARKKLQVCDKMVHSLSETPANEMGGFRIEVSLTDSTLRGAKATADGMPFYDLNWWLDPPAGYEAYKLDFKVLSPKALVQNAKWVLQRAEDLGMLASDNNRSIDKLQKKVMADVQASLGWNAGKLKTTKSLSPTAWWTGRHSDSTLDYTETSSNVVILNYLTKHFDTRTSFQRLITDIRKELGGLVPCPKSLEASPTHMLKRDGWDPVRMLCNAADCGVRLHGRAVYRWLAQLVIKGTISKQTIGIGSGDKDAVIMAQERAVSPDNALNDTARHLIKTYGNSKDQIKDFFNVVRHQLSAKIGAEYLPCQKNPFDLTHYYNIHKFDPKNFSKFRLRCENETCRHGMSAAATWAYIARFVDSGELSRIAVGLPPLRAVDSGELDLPRNTLSNIRQKHVTRVKNVPASPVAPAVFKTHWTRGDGNCMFSAIAKAMGGHLSHDQVRTAGITWIRDHPADFITRIEHNIPQDVYWAELKQSATITDPSRPIMQALEKGYLNVMKNSGVYGDDLILKAVCEAYSLHLVILQELDDKRATWMEVRCDGSEPEAVIWLHLRDLHYENLLVQSQLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WX04</accession>
    <name>K1WX04_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteolysis and peptidolysis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WX04"/>
    <dbReference type="STRING" id="1220162.K1WX04"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1129756_0_0_1"/>
    <dbReference type="InParanoid" id="K1WX04"/>
    <dbReference type="OMA" id="VEKINCP"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="246" mass="26783" checksum="AD3261E53BBBA0D1" modified="2012-11-28" version="1">MSVRFRASASTEPHRKPGLIRSLLSEDPRLINQKDDPDLEASDAMGWTPLLVAASSGHKQNVAELLDVGAKLDAVNDKGQGALHYAASKGNVPINIKDRASQHPLHRAATTGNVAMLNVLLNPPEGRPRTRLNTSDRAGNTPLHLAMESGHGEAAVVLIEAGADRERHNADSQYPEDIDGVGGEEQKRVRQCLVLPVSLQLMMYSTTVIHPLAFDRSSILRHAVEKINCPRMLPRPAQSVWWGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1WY00</accession>
    <name>K1WY00_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000090">
        <property type="protein sequence ID" value="EKD05544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WY00"/>
    <dbReference type="HOGENOM" id="CLU_1483010_0_0_1"/>
    <dbReference type="InParanoid" id="K1WY00"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005686842" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="18217" checksum="B15DC5B874F13A43" modified="2012-11-28" version="1">MRTSAVLFTAAFAASASASSILIPRQDWLKNCEDECNPIADWALGCRTDTVGCMEQCTSELLQQADKCGVCVQEKNPDFGNTVQQYVGMSKQMCGKEGVTTEGDSSEGSASAQPSASASPAGEASPSATPEASASPSASAEAGAASAESASASDVVASASTQAAEASKSAEGASKSAEALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1N6</accession>
    <name>K1V1N6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1N6"/>
    <dbReference type="FunCoup" id="K1V1N6">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V1N6"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_0_1_1"/>
    <dbReference type="InParanoid" id="K1V1N6"/>
    <dbReference type="OMA" id="GHSHMDP"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="297"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="392" mass="43364" checksum="368830FC632318C8" modified="2012-11-28" version="1">MSSDDEIPQSVHFQFTLLTNRLVDSGTDVHERRKVPLTLLTGYLGAGKSTLLEEPWLPHCCVHECTDIESKSLQMSNPNDPSATTSSMLSLPNGCLCCSFKDMGIAAIEEMVAAQKEKIDWVIVELTGLADPAPIAKDFWTNEEMGDLILDSVVCVVDCRNVLRQLDEPTPDDGKTANSTDASGKKDPISAAQKQIACSDVILLNKTDLVTPEQLDEIEKRVRSINPTLRVYKTEHSKVPLPKLYNLKAFSESTLLGGKQEDDSTSCAGCSDGSHDHSHHTDGISTVTLPLPRQITFDQFQNLEKFLQDILWKSPTKESKYDILRTKGYMRVDVEGKIQEKVVQGVADLFDIKDAHATPGEVKPKIVLIGRDLDGPKKESLFREFGLHLMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2R0</accession>
    <name>K1V2R0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000396">
        <property type="protein sequence ID" value="EKC98144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2R0"/>
    <dbReference type="FunCoup" id="K1V2R0">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V2R0"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205521_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2R0"/>
    <dbReference type="OMA" id="ERGRHEW"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="230" mass="25065" checksum="1D58B83043EDE9F2" modified="2012-11-28" version="1">MSTKDQQTITKIQGEWAKIEALQEEKVKLAERLERIVNRARERGRHEWKKVGGIDIDELETDVKLGDLGGADLVLPPQGLGSGHDGRKDKRKGKGTVPLAIQISSAGSSLGIPSPAGTPGGSRSGSVGRGGGRRKEQQQQQEVEVPAADDMEVEGEVEPDDALYCFCQQKSYGEMIGCDNGKCPYEWFHVKCVNMSGPLPDTWYCPECVTKLGLASSDGKVQKDRKGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4A8</accession>
    <name>K1V4A8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_06922</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4A8"/>
    <dbReference type="FunCoup" id="K1V4A8">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V4A8"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_1_1"/>
    <dbReference type="InParanoid" id="K1V4A8"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC98819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="297" mass="31840" checksum="E03CB911C709E204" modified="2012-11-28" version="1">MAERGEKEKEKAPVSPITLEDFAAVLMVFLNAHLASRWGNEVVVYGALPGSAIDINRRRPPEVAATSLVAHDNDPSKNSNPEAEESRILILNATPGGAEDAEATDSKTAKASGGGGGQRGYVGLMNCVFAGQKAKVAIDVLTLPPESTMTAPPIFLQQAAYLTEGIYWRWNGRGGLLQYLHSMYLPPPSLRNKPFTVPPQDAVDFRAVCFCHHDVVDVGFVCIFCEVKPICSMCKTKFPLTSLARLKQLAAHLQPIPIPATVPPPKQKKGPNSGVAQSPVTNKAPPTLPDADVIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5M4</accession>
    <name>K1V5M4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">A1Q2_06484</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34 35">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5M4"/>
    <dbReference type="STRING" id="1220162.K1V5M4"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009484_1_0_1"/>
    <dbReference type="InParanoid" id="K1V5M4"/>
    <dbReference type="OMA" id="QPYRFST"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23 34" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="32">
        <location>
            <begin position="585"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="33">
        <location>
            <begin position="746"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="EKC99284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="868" mass="92381" checksum="CB5C7E22A24ED19E" modified="2012-11-28" version="1">MTSPTPTPSSPGESSLATSIYDSKSEDESFEERAQKWHFATQVVATDSSQNQYGASSTPIFQTATFKGMEGPYDYTRSGNPTRGGLESHLARIYSATQAFALSTGMTCLDVILRLVKPGETVLAGDDLYGGTNRLLTYAKSHGQVDVRHVDTTNVDAIRPHLTKDNKIKMVLLESPTNPLLKIADIAAVSKAVKEVAPNAIIVVDNTMMSPYLQRPLEIGADIVYDSGTKYLSGHHDLMAGIIAVGRPELAQEVAWLINAMGTGLAPFDSFLLMRGVKTLALRMDKQQANCILIANYLDALGFLVHYPNLKHHPKRDVHFRQSSGSGAVLSFVTGDKELSERIVSTTRLWGVSVSFGAVNSLISMPCLMSHASISPAVRAERGLPENLIRLCVGIEDPRDLLDDLEFALVSSGAIVPANGVDLMSSDKLAQLYKSDAPQWAIERARAFRRPQEEGLVEGVNRSLNLSNDTIDGDIVVSAPGKVILFGEHAVVHGVTAIATSLNLRCYGVLSPRNDGKVAIQAPDLEAECEWDISQLPWDAVPAGAGGSKAPTDLDETLLKRIEDIVAEGHPSSTGFRGSVAWLLSVTLTVSANLPVGAGLGSSAAFSACVGSSLLIAHKHVSATSTVSKQAIDLIDAWAFLSEKVLHGTPSGIDNAVSVRGGAVAFTRTPAGNRLHDIRGFDSIRLLLTNTGVPRNTKQLVAGVAAKKAAEPHIVNPVLEEIQAISDEAQALLDGTTVVERAEFVGRLEELMRQNHAHLRTLGVSHPSLEAIVDTTAKHGLTTKLTGAGGGGCAVTLVPDQYEESELDKVLAELAKLGAEPHLTSLGGPGVGVLSGQERRNASHALKVAGPKGLHAWSEALDGTWIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5U5</accession>
    <name>K1V5U5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5U5"/>
    <dbReference type="STRING" id="1220162.K1V5U5"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_2_0_1"/>
    <dbReference type="InParanoid" id="K1V5U5"/>
    <dbReference type="OMA" id="VTIKHNP"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="549" mass="60917" checksum="5D22BA53FF4669BC" modified="2012-11-28" version="1">MVQQANAHNNELLGKELKYFSQAGFDLDRIHIKRNAPVAALYEDAIVNEGAVISSSGALINFSGKKTGRSPKDKRIVYEETSKDDIWWGPVNIALDEHTFEINRERAIDYLNTRENVYVFDGFAGWDPKYRIKVRVIASRAYHALFMHNMLIRPTAQELADFGEPDFIIYNAGQFPANRFTTGMTSTTSVEVNFKRMEMVILGTEYAGEMKKGIFSVMHYLQPVKFGQLSLHSSANQAKSADGESGDVSLFFGLSGTGKTTLSADANRLLIGDDEHVWSDTGVFNIEGGCYAKCINLSAEKEPEIYNAIRFGSILENVVYNPADRVPDYDDVSITENTRCAYPIEYIPNAKIPCIANRQPSNIIMLTCDAFGVLPPVSRLSSEQAQYHFIAGYTSKTPGTEDGIVEPSPTFSTCYGQPFIILHPGRYAKMLAERMDKNKVDCWLINTGWTGGKFGTGRRCPLKYTRAIVDAIHDGSLAKAEYEKFPVFNLSIPKAIPGVPSEILDPAKAWSDKAAFKAEVEKLGGMFNKAFQKYEADVSAEVKNAGPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8X0</accession>
    <name>K1V8X0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulation of translational elongation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1V8X0">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8X0"/>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000504_2_0_1"/>
    <dbReference type="InParanoid" id="K1V8X0"/>
    <dbReference type="OMA" id="KYATQRG"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1534"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1704"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1823"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1845"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="2168"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="2277"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2711" mass="293520" checksum="A917E45E1093A328" modified="2012-11-28" version="1">MPAADKVGSWLGQKGAKKGKEAYESDSEASDITEPEQNAPTPDNDEVVDDDEIVEEDKDSREANIDWADVLPKIRPALLDPSKKRREQFASRYLYVTPESPAPESTGQLLQQLLMTLTASTEWKAVDLIVQVLMDLVRRDEEQQAPMKLGDKLVKWVCAETAKAVDAAKSAPPQVLLPQLNLILALITTLLGSRSDAFVQSAQLKDLLLSLAAVTDGIEARQSPNPRKAWRVRHKVNIRVWRVLRLLRENLQLVAQTLLKAPQPLRSAVLLGNVVGVALRVKMPKGKAPAREAIEAEKPAIIDYYSTNILGSKVALQPYLFSSLSEFLSTFVTDADLTGKLIPATERMMLRSPEIALPVTAALLDECKKDISAIVPGKLVAGVISSSKSSNAETRAKSVNLFQAIVRNTASDEAQLKIANEPAIIDYYSTNILGSKVALQPYLFSSLSEFLSTFVTDADLTGKLIPATERMMLRSPEIALPVTAALLDECKKDISAIVPGKLVAGVISSSKSSNAETRAKSVNLFQAIVRNTASDEAQLKIANEVLSLPKTGKTANADQRVALYNMVSSIPTSAASVVVDTLPPLIAKESNEAALNALGAALGPHLAAVLVSDKPVAAASASALTKELASSKLSVRRAVSTAVGEAAWTTKEPSAEGQKLLDSFAAPLESNLKTASANVPSNPTGFLEGYVAVALALGPLKDSKLATSAPMKEVLTVSPKPSFVLNDKAWIKLPTETDELWLLRAVAALIANNNIEDKAVRVALGLALIHLAFESKHPNVRREVYSTVSDLAAQHPRNTAQIVREALISWLRTNEQRRAAARAKGPTAEEEENIVSKSREIGRLLSAAVSRGSADQETLEDIAADLIVIAHHPEIGEESQVSWITIVQSLGLDPANLVSVKRERILDLLWEVASAPPKDARFAEAAYRAIATLAFVDPVEFVGDILAKIKSDLDPAALDFIGIEERGIWQTPSDQMFTDVLSKKSDQVENKNRKDYAVEKWEQEVREQLAKKKATTPGANLSKQDKALVAAQLRKEAGVREEIALEQARLKRGLELVSSLAASGVSAVESQLGTLAHLLLSSVFGAGAFLVDDRAFEVFIQISGLASDRLDEYRRLTAAAILRGYEAPFVPEDYLQEGACELVTRILHQILFLVNKAPLDPTTYALVSMLLHRVVAVGGIGCQSAQSDEAQEQLTLVVGIIGACVGEFQDDAYPRLETIEDLLKIISTQPRLAKDASSALADLGTAIRDVATPEEIAAIIKGTLSGESNVRNSALQALQPIDLTELNYSEELFIATHDPDAANAALAEHLWEDNGLDIPETYLDSLVPYLCNKSGAVRKGTAEGLTDAAEQHPSQIEPTIKALEDLYVAELKALEPEIDRFGMVIPETVNKPDPYQSRVAIAEALEKFAPLIPDGQVEPTLKFLIEREPLGDRHEEVRRAMLNAATTIVDIHGGKDISGLMSIFETNLATPSTSQTTDYVKESVVVLFGRLASHLESSDKRIPNVVDRLVEALNTPSELVQSAVADCLPALVQDMGEEAEYLVDRLFSTLTTGKSYAARRGAAYGLAGVVKGRGLRALKDYDLMDKFTEAAEDKSSYEAREGAVFAFETLTATLGRVFEPYIVEIIPLMLKLFGDSNTYVREATQYAAKIIMSKISGHCVKIILPTLLDALEEKQWRTKKGSIELLGSMAFCAPRQLSLSLPTIIPHLTGVINDSHAQVKSAANASLKRFGEVLNNPEVKSIQSTLMKALADPSANITKALSSLLKTTFEHYLDAPSLALVMPIIDRGLRQRSSEIKRKSVQIVGNMASLTDSRDLVPYLHELMPLIHEVLVDPVPEARATAAKSLGTLVERLGETNFPDLVDKLLQTLRSDTSGVDRQGAAQGLSEVLAGLGIERLEALLPDVITSTASPRAYVREGFISLLIYLPATFGHRFSPHLARIIPPILNGLADESEYVRDASMRAGKMIIANYSNKAIELLLPELEKGMLDSSWRIRQSSISLTGELLYRVTGISGKVELEEDETAGRGADQARKALLEALGQERRDRVLATLYIVRQDTVSTVRQASIHIWKALVHNTPRTTREILPMLMQLLVSLLGSPHMDQQETASRTIGELCRKNGERIVGEIVPILKKAISSTDSRTKEGACLAFSDVMQSASKDAIENHEDVIISCVRGALVDPNPDVRTAAAQTFDTMQQYMGAKAIDQTIPTLLEAMRGEGEASETALQALKEVMNVRANSVFPVLIPTLTAQPISAFNARAISALVRVAGSALNRRIDTLLSALVKSLEANPSEDVKPDLEEAIEALCASVEDSDGIHLLMMLLFGWAKDVNPTRRATACNIFGTLCQVNEEDMDDYRVDWIRILVGLMDDSDEGVVTAAWEALDHFVKTIHKDELQTLVVPLRRTIESTGAPGRTVPGFSRPKGVQSLVPILLAGVLSGTQEQREQAAFGIGDLVQRTSEAAIKPYIIQLTGPLIRVISGQSIAPQIKGAILQTLTVLLEQVPQLVRPFHPQLTRTFVKSASDPAALSIRVKAATGLGELMKHQPRVDPLITELIGAVQTGEREVAPSVVSALAAVCNSAGQNIGAAAKTSIVELIEEAFMGGHGDSYNNAIASVAAGLAKADAEALRPIVDTFLAPATPPASLVSICIRTMLEDSPDAFYELECTEDVAKKIMASLGSDAANIARPSREARELFRSQPRYKDDAAVQAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V943</accession>
    <name>K1V943_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V943"/>
    <dbReference type="STRING" id="1220162.K1V943"/>
    <dbReference type="eggNOG" id="ENOG502S247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_297399_0_0_1"/>
    <dbReference type="InParanoid" id="K1V943"/>
    <dbReference type="OMA" id="IDAREWH"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="107731" checksum="2532A256DE0006D3" modified="2012-11-28" version="1">MTSCSLTFSVSSHISHSNPTSFQQQQLAHPPPLTAPRPQSGSRHRPRRRSRQRMQDLAFLGPMERSQPGPSKYNGGHLPPVPYIHRAEEVLVGLATARAQSDKAYAFAIVDGYIRSKKARGQVPSYIASKIELLEARIPMNFASVFIDAREWHRLPPSRIIRRRRTPSDAGPSRTSNVGQGTRPQRPVSAIAGTAGGPGGPSMPGGMPSVTQMAAMDRRPPVNRQPVRQQTQEDEAPPPPYSAEDPEPEATRALQESLAAAAEQQGSDFTPEPSHRRANSTSASMVTAQTSLSTSSRRTSGDRPRPSEFPGSPAARAGNATSNGPSAVSSPSIAPSNPTPAADAPPVDTSNMNEEERRAVEESQLEEAMRASRQAEKERLEYEAAVQASLAQAEEDALRRALAYPGESPAESSTRDRKERSRSTSEERDREPRSGRSSKRSSLHAPSVSSVSSGATVRRTGSFNTNKPLPNPNPSALPPVQEPANESLMDMLASIDFNAPEIKPIQPTLAPQGTGGTGGSRGSFSGASEASIEATVASPQSSSNGSWVSGGTATATNSAAPSLGTTPTQPTYIHHAEPRLKSKNPFLAPEEQDPPAVTVAGPPRPTRSPPPPPPRSDTNETARPESYDHHNHSQYLDPSSAEYDHSGGSSPQYSPNWRGDAHGLTINTSPRSGTAPSLSSAGATVAGLTPSTGSHSPSGFPFPVAVPSGLPPSPRPTSEISPARNLPPIPQSRSAENLPQGPPPPVPPRSNLSHTPSASYSSQHSQPLPQPPTQNNHSAAAAAGALELLRAYDTVFLVDDSGALRDENWEAAAHLLCNLVEMAPEGLDVYFLNSKRIGKALKERIDVEELFAGLVPREGKQMGVRLEGVLTEYIDRLEREGGMRKLNLILVTDGGFAKPVLSRAKHARGIADLRHELLSSAGPEDAEAVLVSAGKRLDRAGFPGDQVGVQFVQLGDDNDARKALQELDSLASVHSVRDMVDTVRYRPDSSAIGPELAAKVLLGGIHRGVDAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA55</accession>
    <name>K1VA55_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA55"/>
    <dbReference type="HOGENOM" id="CLU_373060_0_0_1"/>
    <dbReference type="InParanoid" id="K1VA55"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="745" mass="78782" checksum="AF0152C20C0D34A7" modified="2012-11-28" version="1">MGVSSKQTADGTLMAPSSSTPMTTLNEEVTINANPVAATPTATAPAVMDANECASSGSDSPTSSDTPPTTPDTSNSSDLDDDSPKSKDKGKAKAVPVDDDDETDSAPVSPAWSERFGDDDPFMLDDLEAAIMESHRSALTEPKLGESSRNNSISTDSSSSGSPTTINSIGSGTLSTSPDQAYAEFWPRGSAQSAARALVRLADADYSILETDLEADTQSSPPSHPSPHPYSNEPFLFANPGPPDLTDLLAQAQSDSIEPSSTEATRAPSPMPSESVFNQPPVSAITASDAFIPLYEDSFPTTYEPFRLSAQRAFASRDGGGDAESDLPSLTRSSNETLLTWRGSEYTDSVDSSPSLTFTVREMVETRAPFVERPPSVASATSATGQLVMPDAPTATLPTMQQLRRLDIGDDGLSTRHWDEEHWEQRSRNFESPDPFVQENEEPAASEAGDAATEVSARSTAQEMAQVPLVQALEAAEEQDIADVSLALDDMNPFSATPITAEADTEAETTESTEIADVSLSLDTPPAGATAPTAMLIGRIPAIAPAEYPVVRLRRGVLPIRRHALRVADIETARAKRAERAERAAATATETSEAAASPESADHTCAGDSVSAVASLVDGIVARAVAASASLTPCPFPPYYPAPSPPPITPTPPNTPVNDSASPSGGPLHAALGLTLGTFRDVRGRAARFWRGFLNFRLESEGGQPPALAVIVLMTLLALCVPLMSRYFPFDESMAEIWRRRFGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA59</accession>
    <name>K1VA59_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_04773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA59"/>
    <dbReference type="STRING" id="1220162.K1VA59"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_1_1_1"/>
    <dbReference type="InParanoid" id="K1VA59"/>
    <dbReference type="OMA" id="ERKEMPW"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="352" mass="39677" checksum="9D2ADA7DF24711C6" modified="2012-11-28" version="1">MARRNKAPKAKEPEIDDDILDEDSEVDEFENYKPGMAEEAYSGEEDEDEEGEFEGEFDSEDEGDGVGIYEADDWDDEASASDSDSEDDDEGPSMLQKGLQDIPLDTLRKAQKALKGKGKEVDEDDGLTAKERKLREAKAKLASLQRAKGKAGAVESGSDSGSEDERDEKRDGRAQKRDNKHAGDVDEEAVNAELHSKGYAFLPEMLEKERSQLKDEVKRLSKLEKTCKLVEKPGVTAQREEKELQLSKVLNRLSSLRREQAEREVLSKAKREEREKREQGKGAWFMKKSEKKDLLLKARFEQLEQSGGKKAVNKAIEKKRKKVAGKEKKSRAIIENSNRGSRGDGSKRRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA62</accession>
    <name>K1VA62_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Importin beta-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000406">
        <property type="protein sequence ID" value="EKC97605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA62"/>
    <dbReference type="FunCoup" id="K1VA62">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VA62"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="InParanoid" id="K1VA62"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000402">
        <property type="entry name" value="Related to importin beta-2 subunit (Transportin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="924" mass="101714" checksum="3A3BE2A59BA18F19" modified="2012-11-28" version="1">MSWQPAQEGLNEVLKMLRDSMSADTATQRAVTTRLEELRHVPDFLAYLSHVLVHATNEDAGHRVIAGLLLKNALIQRHGPASTEADARAMAYVKSTVLLGLGESNEKVRHTAGTTIMAILYNEETGAWPEALDALTKGMGSQDANLVDGVFNTFQKLSEDCPHRLDMTVSGANLLDHLVPQFIAFAGHSDPKIRLYALETLQSLSALRIPSINANIDAYLQSLFQRASDPSADIRRTVCAALGLILGSRPDKLVPEMKNVVDYIAYCTTDSDETVALEACEFWLTFAEDPNLKEQLRPYLGKVAPLLLEGMKYSDIDLLYLDNDEEDEAVPDKETDIKPRAYGGKSHGAHETNEASASSGGAGKSREAADRALDDDDEDDDDDFDDDDEDGAAEWNIRKCSAAALDVMAVSFGNDLLEILLPYLKERLFHDDWRYRESGILALGAIAEGCINGLEPHLSQLVPWLITALKDKKALVRSITCWTLGRYSAWIVAVSAQDKQTFFIPTMEGLLQMVLDSNKRVQEAGCSAFATLEEEAGGELVPFLEPILRNLTYAFSKYQQKNLLILYDAMGTLADSVMGALGTPQYMEILMPPLIEKWMSLSDSDPDLVPLLECLSSVTLAAGKAFGPYAQPVYQRCISIIHQSLMQWDAFTASPDTIDEPDRTFIVVALDLLSGLAQGLADEMPSLIASAEPPLLQLVAMCLNHFEPPVRQSAHALLGDMAMTCFPLLRPHVPQLMPAIIEQITPEPPTECISVCNNAAWAAGEIAIQYKGDASPIEPFVDDLIKRLIPILLNSKSPKSLSENAAVTIGRLGLVCPSLVAPHLGTFAQAWCIALWEIKDNDEKDSAFRGFCMLIGANPQGLESSFVWFCNAVCKWQHPSRELDNMFRQILQAFKAQLGDEGWNAQVAAFPSVIRDRLRERYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAC5</accession>
    <name>K1VAC5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAC5"/>
    <dbReference type="STRING" id="1220162.K1VAC5"/>
    <dbReference type="eggNOG" id="ENOG502RB90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499847_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAC5"/>
    <dbReference type="OrthoDB" id="3219336at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="254"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="545" mass="60886" checksum="AEBF79387DE84F8A" modified="2012-11-28" version="1">MKRLQDASCAICMDSLFDLRDDLDEVLPIATPDCGHVFHERCLLDWFKSQADVYLANAREYRGEELTAADAPAECPQCRTECFADPESGEPAIHRLFINWGDEEAMSSQMVGSSPPRPTQKSWKRPADQELLNLARRARNLGAEVNSYTADSNEDDVMGTLRRAESLRMDAAETKAAKGFKAYIGGLTRALNEFSGRLEEHPLVGTLQTRLAAAEQRVRDREADLLRFQRVELPRAVSDAVRQETARMERKVAHADAQRELMQHELQKEQVARRNVKRAAYEREQELESRLKAQEERIKGVREDAEETRSRLDDRNKQVQLLRSREMKRRIAELEAENAALKAGGAVPAPGAADAADADARGRSESATSLPGTPEPTEAEESLMVDMPSLQGLDSSPPLPRRSTTARTFSYGPTGKPSKPIKSKTKSKYFSTPSPKRVLVAASSSPLRPSHTVVMSPEPVRERTKTNPFKKPHPRPETRPETRPETRGVKRPTPSPEREVIVLDDTPPRPPKKPVPPLGIIDLLADRNGRPKKGLATGPKYRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBG1</accession>
    <name>K1VBG1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000318">
        <property type="protein sequence ID" value="EKD01375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBG1"/>
    <dbReference type="HOGENOM" id="CLU_1983130_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBG1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="126" mass="13278" checksum="1B36BBD0FC3054C5" modified="2012-11-28" version="1">MAHALSVRRVIDQRPDSGRPHTTETRRGAAAAHVVAKEPQAPRNTSLKDTTQAGGMLGLVPGANDGDSAMNIHKLSRASDAHLDDVLESHDADSALLAARLGRHQQDMTAAGLEAVVSPADEQMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBL3</accession>
    <name>K1VBL3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBL3"/>
    <dbReference type="HOGENOM" id="CLU_280480_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBL3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="984"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1120" mass="121240" checksum="3EE60E84C339D563" modified="2012-11-28" version="1">MSSSTSSSPPSSPSSPLTLEGFQLLTAQTISAPAHGPGKGPEDIESFTSNRPNPVRSLSQDSQGSFGSRGHRIAGRASVTLLRVSDIKLSNRSSWSSATSSPPPSARSIMPDSSPPRLPQTQTQTSPSQDTYTRTRSIARASRPPALPLASSSHDGLGGASGSPPDRLLVRAPTPPKSRRQRTFTVPPDATEPRGASTAAPATPTAPEPTSAHSHRSFATFGGDREAESPRTKDPPLPAPPSVPHRAPSPRARHQSLDTRQAPIPHPPRLSSISHSGVPDLPKLHVPTRTSSLATTGSGVAAGNTAHVQISSRHQTRPSKAQHTRDDSDTLGPSPWANRRARGSSVYDNAGGSKSCIELVRALEKWAQHCPIAPPCISRLIAAPISVKRQRTYAAHSPPEPARRGAPPASSEPSPALQAARAYLTVGRRSLPQHCDARTTTKGAPDPPQPQARAGAGCVAPRVRRGAVEASWPENRGPEWSRDDCVPHLADEEDHEDRMPRRTKSKLRRPIEAVKVPENLQVYVSRETSVTETVAPATHNPLDSAPSSPPSTPPQTREEAIRARRRAQLAKLQRILGSPISPRLVLAPDDDVPTCGPVRSPSETSLGSPRLPLRERVKSFVIPSPIYAMSETERRLARKRASKLEHLFGDAPPTEMIFPPVKHEAAHKHALDKIREGAPTVGVAMGVPGIEENRMFISTSPAAAVYHTPEETFEGYRHSLLGLMNLIEHDQVRLAAIVDQLEPQLYTLHIQSSLALQMGRHPRPGLGHPGQQQRPARTNQASGPRQSHHGDVVLNPGPTTLQRRSSAPPLPSFSRANGAPDTKGTPANGAASSHGHGPRASVHTHDPGHGRQGKGHTPHASVSSTHERHERPSLQSQRGHADPFSEYLRSQSAESRLDISAPHEREASSATNSTVRAAPSSLGHGGHEKDKEVLKDNPREKKGPYGTHATSPRMLSGFFGKPKQAKGHVPHGSVSVMNLSRIPQQAHPAHAAHPPHAPHQPHQHHPQHPQPHHQRETTQEKEKDDSPPATARAKRGRKFSKLFSSHPKPPPQPMILRPNPFYIRRQTLDGVLAELRRSFLLDLDHGRLRPHDAHILHDMLELLNHMRAGSPWAELEDSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC52</accession>
    <name>K1VC52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2">3.4.22.40</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Bleomycin hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Homocysteine-thiolactonase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Leucine aminopeptidase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Y3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04126</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC52"/>
    <dbReference type="STRING" id="1220162.K1VC52"/>
    <dbReference type="MEROPS" id="C01.085"/>
    <dbReference type="eggNOG" id="KOG4128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_1"/>
    <dbReference type="InParanoid" id="K1VC52"/>
    <dbReference type="OMA" id="DDGGWWQ"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="557" mass="62511" checksum="FBA46A63AB346A11" modified="2012-11-28" version="1">MLGAWDDKVPSPAPAYQSATSAVTVTALTAFSPALREHLAGTHSISPADITFITPHPRLNTMGSAYSTNKSAMTNTVETIDEKKQYLADQKAALQRARSASLDASAEAVPELTADVCNKWDKDLEQLARLILTNNDPIATLKRRDAVIDDEKVFNVNLKGTGDKGQYPGPRVNQASSGRCWLFATTANVLRYNVIEVLKLGDFQLSQSYLYFYDKLEKANFYLETMLELVDEPIEGRLVSFLNQAPVNDGGQWDMAYNVVEKYGIIPHALYPDAFSATASSRMNWVLTAKLREFALDLRKLSKTASKEQLAKVKASQMREIYQTLCITLGTPPKNDDKLTWNYYDKENKFHSWSGTPLEFYDQFGKRKGMDPKDSFSLINDPRNEYGKLYTVKRLGNVWKGPNVRYVNAPIEVVEDAVIAGIKANTPLFFGCDVGKFSESKNGIMDTRLYDLGAAFGYELKMDKAQRLITGESSATHAMVITAVHVGEDGRPIKYKVENSWSKDRGEDGWFMMTAEWFREFVYQVVVPRSIVDKKWVKVLDQEPIALEPWDPMGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCU9</accession>
    <name>K1VCU9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCU9"/>
    <dbReference type="HOGENOM" id="CLU_2251934_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCU9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="104" mass="11462" checksum="FB87812D46A4B5E6" modified="2012-11-28" version="1">MAHFCPIPSSHSFHGELKEEATAVISAVNDATQKYVGERASLITESVESAKNGTLSRAACSMKVWQCKGAYSEDVTKMVRELHDQIERACSLQLQPPKNKHFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDE5</accession>
    <name>K1VDE5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDE5"/>
    <dbReference type="FunCoup" id="K1VDE5">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VDE5"/>
    <dbReference type="eggNOG" id="KOG1438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_1"/>
    <dbReference type="InParanoid" id="K1VDE5"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="11">
        <location>
            <begin position="112"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="462" mass="48924" checksum="952126525D57CE3B" modified="2012-11-28" version="1">MATGLSPETFKHLLKKLVQSPRDFTADDCGEAFEHLALNASAPAQAGAFLTALTLSGMDSSAEIVAACAAVLRKHALTVEHHMPQKDTPAPDLTHGNWDYKDSDVEGDGYKGIVDIVGTGGDGWDTYNVSTTAAVVVAGAGVRVAKHGSRAATSTSGSADLLISLDCRLSFPVEEVPKFLPASPFLFLFAPHYHPALAHIAPIRRQLNFRTIFNVLGPLINPARPQRMVLGVAKRELGDTFAEVLRLLGVDRALVVCGCEGLDEISIAGPTWIWRLENGKITPGEIHPERDFGLPLHPLSSVKGGTPDENALTFNSILDNSAPPPHLASPADENSPSLEAIRDYVLINAAALLHISGRAPTWRDGVAIARESLESGGARAAFDGFRDMSKRAMGEKGLDLPPAPEDDGGVAARNGFVKAWLHSRRNSGYGSPVFGSSRSPVFGSSPGSPGAIPSKPLAEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEE1</accession>
    <name>K1VEE1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000288">
        <property type="protein sequence ID" value="EKD02375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEE1"/>
    <dbReference type="HOGENOM" id="CLU_1994219_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEE1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="130" mass="13749" checksum="73D258E6BE7F9038" modified="2012-11-28" version="1">MHHPHTTSKRAVSDTSAGSAGRQRAHDAIGSHRAVPEQPDVAFGSPGTPGTPGYGHVTPAPVSASSQFSHPTGPQLIPSQSESELRPDRDFSFGAGLHRLGSTWPVLHRARLLISMHLLVLHLASLDCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEV6</accession>
    <name>K1VEV6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEV6"/>
    <dbReference type="STRING" id="1220162.K1VEV6"/>
    <dbReference type="HOGENOM" id="CLU_1344088_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEV6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="204" mass="22102" checksum="402CAEF5E6507520" modified="2012-11-28" version="1">MKALSKPAALDSDSEHEVQAKFDEYDPNEAEPEQVERIRRRLEAQKLEANRTGELQNLQEQQKLESQKMQARALRRNNTGNTGSASTPSGPTPATTNTFQDLQDLDFGAVNPHLPPPMRPDSDDDAYSGGSLSDFSDYDSSDEEYRRGPVTPLSFRLKGPRALAMPSVPSPLAYAAIARNAPGSASWAAAHGHPLAPGLSPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF41</accession>
    <name>K1VF41_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF41"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_7_0_1"/>
    <dbReference type="InParanoid" id="K1VF41"/>
    <dbReference type="OMA" id="WMAKKLV"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="77012" checksum="4FDCE12270F3F18E" modified="2012-11-28" version="1">MIRRVRPLLHARWARTVPSLSLKRAGGSRTTAPLALHTPLCLMSTEAGPSTPAAQDAERPTEPTRGESDDKQRTDLLESYRELVSSGRLKWDDEQVRVVMKLRHLIKDLEEYEPPMELLAKLGPTPPRRPKRNWWHGRGDHAEFGATEKERALVRVMTGEEEIAALTTPKSLLLSLAFDAIPTPYKKRHHYHAFTLWLYQRVFAEIEAYKNSAPVARHESNMNKAGAKGWRSVFASGRWKEGADVDLSDQYPQLDDPRDTIPFRIAKEMILDYHILYFDELQLVDASSATLLKDVLGWYWRLGGVILFCSNRLPEDLYMNGVQRERMAGFLDGLRARSELVELDGGRDWRQAGGGEERWLGLDDQKFDDWWAKEGEGSGEPKTLGVYGRRVEVPAAKGSACKFTFGELCETPLGPADYITLSSTFRTFYLDEVPVLLLKSKNEARRLISLIDALYEARCKVVIRAAADPEHLFFPDAVDPSLDPDMFDPIAAESLSEALDAQPLANVSIYNPRTRAEQERDQMSDRGTAFAVSNIFTGEDERFAYKRAVSRLIEMSRSEAYQKEAWLPLDERAWEAFGAETTAAVREPRRGIFADPMQRSYGGKGMGPIARSRMHNDVLDSMAAESGAKAPGMQEEPIPPSPREGAPRIKEVHAWGVEDRWGPKAGDWGKGASVYDTGYKKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFB0</accession>
    <name>K1VFB0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFB0"/>
    <dbReference type="STRING" id="1220162.K1VFB0"/>
    <dbReference type="eggNOG" id="KOG2508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_6_1_1"/>
    <dbReference type="InParanoid" id="K1VFB0"/>
    <dbReference type="OMA" id="PANWWHR"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="93"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="234" mass="25934" checksum="3D91954120AD9FC6" modified="2012-11-28" version="1">MIEESLLESHLENLTDDYHDGVATLDQPPSAIEALRMINRSQPVIIKAGTVKNWNSKSTYIEIMGQKPVSIAVTDDGLCANPHGRVDDEIHYLQSQDGNIYRSTPGARGPPELADFQPFIERDTVWMKEATGYSAEAVNLWIGASRSTTSLHHDPYENIYHVLSGSKTFTLVSPIDGLRIEPPDVPWVEGTDIPAHARHTIVTLNEGDSLYLPANWWHRVEQQEGEGGLAVAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFH8</accession>
    <name>K1VFH8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFH8"/>
    <dbReference type="STRING" id="1220162.K1VFH8"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704345_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFH8"/>
    <dbReference type="OMA" id="SHANSFN"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF317">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="392" mass="43991" checksum="D1BCA2473E4A7982" modified="2012-11-28" version="1">MDQKPIGSKPEYEYSSSFNAYNMNAPGAVPAVPPSLSPVTPLNSEFPATSSTQEEYYDRRQGPNPPPQSSENYTSPGFSSPTSTASRRSSDQNYDSKSPLAGKPETEAIIIPPIVPPSVQWPTTNFEDWDDLPDILRQDRKADFTPRRPMNVYFIYMRVRRSELALHNPQLQTGELSKILGREWNNMTPDQKAPWAELADRLMRAFKKKFPDYQYERGGSRRNGRRRGGRGVGGAFTVVTPHMMVENAARRSSVPSYQLAHPRSMPYPDPQSHQHQQFGYRDFANPAQYPMHQGGLAPLTAVPLHYAQGQWAPMEAAPHHEYAHPPPPPPHAAQQYYAQPSEGPSSYASAYPPQQPQYSHAPHPPPSHQSQPAMYSQPQQSEGGGWDEYIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFP8</accession>
    <name>K1VFP8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_07703</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFP8"/>
    <dbReference type="FunCoup" id="K1VFP8">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFP8"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="K1VFP8"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="77"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="425"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="260"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="115"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC97906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="538" mass="58792" checksum="08151BDAAC108086" modified="2012-11-28" version="1">MLTTTHHFTALARNSTVQQVKRSVSTTTGLIPNTRNSSFARPARLARAIPPQRFFSSTSRINMPPLPIQKAEEVGEYDIFVIGGGSGGLATARRAASYGAKAGLVEGSHRLGGTCVNVGCVPKKVMWYTAEVAEGIRHASSYGFGTEAEDKKIADNFNWPYLKEKRDAYIKRLNGIYDRNLAKDGVDYHEGHASFVDPHTLEITKEDGSKYQVKAKKIVIAVGGVPTVPTEEQVPGAQYGITSDGFFELEEQPKRVAVVGAGYIAVELAGVFNSLNTETHLLIRTEHVLRTFDPMLSDVLVPWMEHTGMRVHKDTGVEKVEKTATGLRLTGKNIDIEVDCLIWAIGRHSNVEGLGLQNAGVEVNKKNDIPVNEYQETNVPDVYALGDVAGKALLTPVAIAAGRRLSNRLFGPAQYKNDKLDYDNIPSVVFSHPPIGSVGLSEPDARKKYGDDDIKVYKTSFRAMSNAMLEEDAKQPTSYKMICQGKDEKVVGLHLIGEGSDEMLQGFAVAIKMGAKKQDFDDTVAIHPTSAEEVVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFR5</accession>
    <name>K1VFR5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFR5"/>
    <dbReference type="STRING" id="1220162.K1VFR5"/>
    <dbReference type="eggNOG" id="ENOG502QUAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFR5"/>
    <dbReference type="OMA" id="ISEKWHP"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55236" checksum="466BC84E7D4D7500" modified="2012-11-28" version="1">MIRAHSKRLGPIAKRGLETAAHPPPPPPMDMGMGMMGRAARKPRAEGDIGSVFASLSNEKAQALPPRFRDLKRVLMGDADNQARLIASWTRLTDRLARAASDIERRQQACVPVLSYDELVSGDAKAIARFKECGTAVLTGVIPESTAERWLGEVEAYVAANPDVKGFPADDKQVFELYWSRPQLEARSHPRAMAVQRALLNLFSGSDGPAAKQPLAYADRLRVRHPGDSRFALGPHMDGGSVERWEDPAYRAVYRDILTGRWEQFDPFELGARARANQNLYDGPGACGVFRAFQGWTSLSHTGPGEGTLRVYPRLRELSAYTLLRPLFRALKTEAEVGREAYLASENWVLDTVTSDFPNAPPARSQEFNDETHPHLQLARTMVSIPHVRPGDQAWWHADVIHAVEATHGGNGPSAVMYIPSVPMTPLNAAYVADQREAFVNRIPPPDFPGGVGESAFRGTGTPDDVKGSDARRAMGLEKFEVSDTMPANERAVVEACNKILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFX2</accession>
    <name>K1VFX2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFX2"/>
    <dbReference type="HOGENOM" id="CLU_291376_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFX2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116446" checksum="48F86ADF6CA27548" modified="2012-11-28" version="1">MVAPETPRSSFARRIAKGKGRARASSSDSDGDDFLEELEIDGDDLLAADGGSDDESENGSDDDELWLDDGSEAARLDIEDTIKAAATVIQTLASLEDRLRACDEMDDKLDARLGRTALKKRARLSDLKQVAQGKDAFGWKSDLYVDDTSPIPKAVQRVVNVISRARALHPSPDKREQLDSGGPARHSRDNVDMTTVIDNMAKKGMPRIIRDLIDLQAMCPEVDISGLAAFINRLEAMTSASVSRRSVFSKGLRRYLAEKEAGDLFLDGSNPGFGWRAALPESSIERVIASYSDRDIELIESIEEKLKSDAVKWRVKRLVKKVRQRLSKRDKKAVELVYNADSVCTLVYGSETTTRELATLVSRVVLRYLLLCGKLWVLAKRDFSSAWLDPIAVFMHLVESVVVAGYVRFRDKDGKPELLGTVDLISGLPHIRGGLSGSSGKVTYLAHEQHGLPASMYNGDDDDDSFGNHGHESFPVNLTRGSWPFPTMWAHLSSRQPALQKLADKLAPVGVLQKVQLPDFEPTKQMEAMWRHNHVDPLDAVARDPSLPQRMKEGLNSAEQEVKNAAAARRQQQADADKTAKAQGRHLMAGRCDTCGIALLSHGTCVACRRDAKRLEGQRKHLQRFEQALRKAKELGYVGNAKPIVRAAEPRAIVPRLPDELNVGYGIQAAAELQETFFSFECARYRRVREKGWAEGTADASICDICVHVERRNSDEFQRRPVCYQCGIDKCREWRKGPVWAAMICLPCWTSHLDGPQESWHLPVPGVHNDLGSLAVVARQGRRRQSLYAPSQHIAPPDQWRRAQEAHGLVQKAVAAAATDAKPADIKEELARLVAAQGVQASASSATRVYDKRPTDDSFDPRAVTSRFGVPGVCLFPQCDSTKLTNGFPVVTRVGGLCGPHHSFISRKSNHDVKQAMVRCLVEVCEADPVGSLKDAFAAAVKTKPRASNTTGSHAIKFTSVSQTDASTGKPKAIFKDIQTAGDRCPGLWINYISSCRQVPSSTALYMAIAQDVFSRRSQRVAFCYQFYRARRNSCLFSLPSLPPIDDATASSLAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG45</accession>
    <name>K1VG45_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="6">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG45"/>
    <dbReference type="STRING" id="1220162.K1VG45"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023294_2_0_1"/>
    <dbReference type="InParanoid" id="K1VG45"/>
    <dbReference type="OMA" id="LTHEKDS"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="7">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="8">
        <location>
            <begin position="333"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="507" mass="57030" checksum="B62392439AB78F8E" modified="2012-11-28" version="1">MDAVNTNGKEAVRLCEHVVRQAFGDVVGASLIILLQHHLVGSTGGSRRNPPEEEMYEFDIIECLMRLRWGRMLALTEKEFGEEIFLYGKLTMEEIQDVLAEYDMSASSLRRVVTLMLRRGFLEPTCAELTMLRSDQIDRRYRELKKAAIDEITDERMDFRNPSRALKELKVPKKSSSSALKGKSKGENWDVVDGVPLRANYDKYNVLIRNEMIIQAATDRWNAAAGEVMRAALAASIDSQSDPRELRTSVAVNVTQIVDRIPQHAYKLLMAGMVGTGSKNIPEITRQYLAVMSGDDLASGGGGGRFLTHSDGTSPTFFVELEAICTALKHSLLTELVRERIDEKAARVLAVIAEAKFASETMVRDCAMIPLREARHILSELQKLSLIDIQEVPKTAAKGRNMFPGNDFHLWSIDLRKAYGFLLSGVYKTAANVMQRRQHELEKRSVLLEKLERDDYTPEQVVEYLSAKDRQDYDELNNALQMLSLAETRTDLIVMMLRDLPGGAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG64</accession>
    <name>K1VG64_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-1-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG64"/>
    <dbReference type="STRING" id="1220162.K1VG64"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="InParanoid" id="K1VG64"/>
    <dbReference type="OMA" id="HGRQGYA"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="234" mass="25341" checksum="45F8E1BBE40F828D" modified="2012-11-28" version="1">MSPQSVTVDAVLFDMDGTLLDSTPGVEATWEQYKEKYDLDLDEVLKHAHGMRTQDNMKNWCGIKGEEESAKEAEKFEGLIVENAKRLQDMGKTGLIILPGVKDILESLNTAPEPCWSIVTSARYKYASAALPTAAVPPHHHLVTANDVQNGKPNPEPYLKGAAKLGVDTKNCVVVEDAPSGIKAGVAAGAHVLAVCTSFPREMLEGLGAEWIVEDLTHVRAEPIDGRVKVTILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG95</accession>
    <name>K1VG95_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellular response to glucose starvation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000360">
        <property type="protein sequence ID" value="EKC99835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG95"/>
    <dbReference type="STRING" id="1220162.K1VG95"/>
    <dbReference type="HOGENOM" id="CLU_756909_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG95"/>
    <dbReference type="OMA" id="MMIMEAM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="366" mass="38518" checksum="16AAF3B6356828B4" modified="2012-11-28" version="1">MPSMMRQVGDRLIPIGYTSSRATGTADFSMSIPQGEGRRSRRTRERERELEEMMIMEAMRLSLLDHEEHQRKSATETQNKNQPQGAPQTQGQPQAAPEQTRRLSTNQPPAGGQTPSSPMGATPSSSRRSSNAAGTMASWRASSNDAHNNGHGGGRAQAAASKLLSKITVNRSRANSKSSVHFAASPTTMGGGSSSSSSGPGPSSARARSASASTPSTISSEHHPSPLGSNSLGPASRRSLDVNATRTQPQTLVSDRDSITEFSAGPSAPTPERSNSDLIDMGSVDSHEMTTTPPDVDEPSTPRMAPAASAPQTPTANVTQEPLDISPSRHSMAESFESRSSMAASYTDPVPRAARSKPLAAMADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGD0</accession>
    <name>K1VGD0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGD0"/>
    <dbReference type="STRING" id="1220162.K1VGD0"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020372_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGD0"/>
    <dbReference type="OMA" id="HEAGQAN"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="190"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="627" mass="68797" checksum="1F3E6D72039B87C9" modified="2012-11-28" version="1">MRNVANYTDFADIVLIRRLISITYLIPLPADAVVTPITFVVPKRRADALRGFLREFDLLESGTRELTGEWVVGNEVWKRLKSERRAKWHAELRRRQGPGPSRLRDDMSDSGSSAAPTVPLLHGHPHPPRPGRRSYSGPRTHSRGNSLNGTISGLPGSSADSTQQTPRQGAATPEPEMEGESPGRRERVIYYVHGGAYYVGNAATHRLITIGVSRACNARVFAITYRLAPEAAFPLPLLDVVQGYMRLLAPPLSIPPENIVVAGDSAGGGLSLALCMYLRDNDYPMPAGLVLLSPWVDLTMSCGSWEENGDSDVVPLPPLDSHLNPVGCYLGPDGVGAYVTHPYASPLFGDLRDLPPMLIQSGDSEVLRDEITLLAHKATLAGLNVTHELYEDMVHVFQMFTWLPATTASINSIGRWVRQTLPRIEWEARQNELHDLEEEPLHPPLHPHDAPHEHDEHEAGQANPYDAEEDPFFAAFNSERRLRRSHTQHPLHVRSPTSPGPRSRAGSRAASPSTLRRRRQTASMHMSSPVSPVENHPFNVTTSGLASAFSTTGFDALSPTPSVRRRLRAPSSHPTTPSTRARNHSHTDIFELVEGYMEGGAANATVVYAPGGEIRSVGVLGDESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGR4</accession>
    <name>K1VGR4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGR4"/>
    <dbReference type="FunCoup" id="K1VGR4">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGR4"/>
    <dbReference type="eggNOG" id="ENOG502QSQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021703_1_1_1"/>
    <dbReference type="InParanoid" id="K1VGR4"/>
    <dbReference type="OMA" id="CFRSASY"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39091" checksum="104E453B9CBB8409" modified="2012-11-28" version="1">MGHSDVPAALKKPKLDPGSGILSLKDGVFTTTQASYPLKLLSPHAVGVRLAYMIAYGGGLVAGDHIHLDVDVDGVLVLLTQGSTKVFRHQPGIRRPQSHLLHSIHHSPETVGKLEGDEARPLNTYTGGRYPADLRVDEPEAPTSRQRMLVKVAPGSTVFLLPDSISPFKDSRYIQSQRFVLSPGASCLVLDWVNSGRGRFEPAPVLKDKIHVKDYVHVPTEADEWWAMDYYASINEVVIGDKVVARERMVLQDQPGNSIKDRLLPYHVYATVLVYGPTMAKTRKLLDAIADNESQFQIPRPPGLIWSWSVLDEHGGIIRLAAVHVEDIRDWLRSVLTQGGMADVVGEGLWPRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH00</accession>
    <name>K1VH00_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH00"/>
    <dbReference type="FunCoup" id="K1VH00">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH00"/>
    <dbReference type="eggNOG" id="KOG1876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107765_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH00"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28608" checksum="2EA85A4D2866DBDF" modified="2012-11-28" version="1">MQDRGSLIGSSDRMTLRVRGQRGTNNEVDRGARPDSTLERNKATTHPEVHADGHFCDVVVGERNKIVEHPPPIPERGPRDAHGGAHARELLVPGRRATQQARGRVEPNWPHQLQPTYGLANNRNTPEVLLHPLIISRNESERVLIEPSINSIRVSISIKQADDIEKILCHKFTRFMMMRAENFVILRRKPLPGYDISFLITNFHSESMLKHKLVDFIIQFMEDVDKEISEMKLSLNARARIVAESYLATFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIE5</accession>
    <name>K1VIE5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIE5"/>
    <dbReference type="HOGENOM" id="CLU_2293661_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIE5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="101" mass="11474" checksum="B1CD92F73ABE0922" modified="2012-11-28" version="1">MASLCPPPYALPPSLPPFPQHHIRLLIPSEPHLIPPALGHLLTSSEYPTLRLHFEQRVALTYPLRPALLDELTQLESDLYAWSGDEALWAWLKGVHAEHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ28</accession>
    <name>K1VJ28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ28"/>
    <dbReference type="eggNOG" id="ENOG502S284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268748_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ28"/>
    <dbReference type="OrthoDB" id="3353982at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1220" mass="133350" checksum="C5E89ED7246D9FCD" modified="2012-11-28" version="1">MSSVHNIPHSPTPQPAKKLRPSLSPARGCLRPSSPPVEFDASSRTSSARSSFSDGSDYRRCKTVHWQGEVDGCVVTKCFDTYSASEYDRTPLAPPSEQERSCVLPARGARCLSYMDDDEDDDESDHDEAMAEASDSDDDTRPSSPFASPEDSDLSGVEDDGDEWSACFARRRMMFARMSSLDRESAQPQFEGYRSLSATLVELLKSVGCDEDDDTTTLSSTPGSSADEGGMSKLSSVSSNESIATVVFSRLREERPEDDERETEPEIDTPSLISSADSEAECSIASPPCSRVEFVPPPIMWTRTALTYGPQDGEKSHGFPEDCLVCSTASTPPPHIPISLPITTAHFSNSLRSPLWPAPREHSGTSATGIAGHAGHAGHAGRATQAGSWELEPELGAGKNVRTAANGTDGMGDAGNDPHATAATAGSDAILSNGHAECAPTDTANGVNDSNGVTRPDTSEPNDDDTPDDTADSPGQQTSLLSLPPELLDVVLAHVPPAQKLSTVRALSLVLPYSVSRRWRWEHLVLTSPRQFYPLYNALAREKERRMREEENGGQRGAGRGGDELVRTLCVECWKGDVDMLNNLQTLMLHVGTNFAPEHLEDMFASPRPDLSRLELRFRPYVEEANYYQFLKGSYFDKALHTLQTWPETPSFRYLSLVQDLLPRKHLPIPRTRVAKLSGALDGSEDPDADAPTPTPEDSELESDLENLSLGPSEEGTPALTPARGTPGTVTPRTMSGAQTPADPPKDRGYTGQGMFPYLSQKLQHAKPKTFAQPIVFFDVRCVAFLSSAPVAKHLTHFRLRVPSRDIAYVLVTKPEPLAPVAFSTNTPPAPVANGGAPMFPALTYLDISTTNVRLDAVLATLLRNYDRLEHLVLDRTNLFGFRSKDKGELMSRELGGLCVTVCLQRAKEREKALAAWDTRMRTAAYLREQRAQEAQRSAASVRGLSAAERAELDLRRAEEEEAARQAEYARHRRGHRSAGQSTISLRTNSRRNQALLAASGGVNPADLPPSNRAYFVLPALPRLRSVNIGGEAVGISKFYDLNIWRHAFREGWVESVQRNLGWAKNATEKYVRARKKIAEWQAYTGSLHQSRGKKKPGGAKTQPPLDVRLFRYPLPGETPPPPTHAGEEEEEEDKALAGLIEVDEAGALEYLATYKDYLGDCERVGGFPCVFCLTPDCEGPYRRGGEGERVDGRGGMDAPHEPGCGHLLGRRIWGWEGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJG9</accession>
    <name>K1VJG9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJG9"/>
    <dbReference type="STRING" id="1220162.K1VJG9"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="K1VJG9"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="77"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="176"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="494" mass="53627" checksum="25678D3AE71007C6" modified="2012-11-28" version="1">MVQDPVDNYSTRAAQAIANRDATIPQDWMLPKSAFPLPNNVTSLLSLKLSPEEMAIVELPAYELRDKIAAGKLTAVDVTTAYLKAAAVAQQTVNCVVELIPEEALERARWLDEQLKTTGRPVGPLHGVPVSLKDHINLKGHDSPCGILSFVGNMVAKDDAHLVSILRDAGAVFHVTLTSGGSSGGEGATMGMKASALGVGTDIGGSVRSPAAANGVFAFKPSSRRLPYEGCNMPVGPAGWEGVLCTQGPFARSARDLEEYMRVILNSKPWEKDPRDDGVVEPVTPIRRALEDAVEKLSAGRGDTTFELVEYTLPSPEEAWKIITSLYWPDAGDMVRSNLAAANEPVMELTDWILTEGGQKPTLDEALERIVTRDQWRSMLAKHWHDAGLDVVLAPVGPTPAPKHGTAKYWNYTSYWNLADYPAVVFPTGRFVDPTLDVHQPERQPRNEKEAFVWSNYDADTFAGAPIGLQLIGYQSHDEETLAALRAVLAALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKB7</accession>
    <name>K1VKB7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKB7"/>
    <dbReference type="HOGENOM" id="CLU_346887_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKB7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="94886" checksum="411BD943DA34524E" modified="2012-11-28" version="1">MPTIDAQFHPHIVDMIWDHMTEDSAIIAGNVCRSWRDRAIPLLMKHIALHRRDDNEDADPVLEDMPIGAPLPYRRITGRVLIKSYTIGSKRTMLLKSLRYRRREIYNFDADEWFYEKEEIDEDLGMDLQKLLAKAEVVEAVNWNLHECQLGELTDLLFRSTRQVQFEARTYDMWSPIRPADPLRTETASIRPPLVRWRVQDYTMPHWDLGPSEVLFFLDYSHAQNIAEVFIEDFDKVYGRKPHACRHLTLSIDCYCDPVLGMWDITRSMGPGDVRGRQDDCTILLFNRTGKKRGEGFDDVGHTRGLLVNYFETFPNGVFSDVTVVGLEEFFEEQEPLEQYQDFLRKQFKKTAKEHGLHLRPSASGAVLVFRTHAKHKAIMDDYYGPGGYERRALSGGFLRPKATRVHTNGLLNIEFAMLDAKLYPEVIDAVWLFMSEDAAIVAGNVCRNWRDRATEVLIGHISLHLHEDTIREDEVPQETYEGMDPSYRNIDGRVLIKSYQVGSKKTLLLRSLPYRRQEIFDWDRDDWKYEKEWVEEELGEKWTRLLARTRVVDVINWGVNECRLGELTECLFWATNQVRYNDDSWPDYGPFRELYDGVDDDDDLSEEPVPPLVRWHNVGPRMPHWDLGPQHLLLFLRYSHSKITPEVESVHEKYTMGREPQSCQNLTLSIDCYGDPIQQTYGSWPALGQDFHEWGQEVFTVLLFNKTKRRRWMSFSDVGNGRGLLVNFLETFPSVTFSDIIIVGLEEFIDDKPSLETYKRFLTQKFKKKAKASGLRLHPSQFGARILFRTHRGHKIIMNRGYGKSGYATHALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKR0</accession>
    <name>K1VKR0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bud site selection-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKR0"/>
    <dbReference type="FunCoup" id="K1VKR0">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKR0"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024195_0_1_1"/>
    <dbReference type="InParanoid" id="K1VKR0"/>
    <dbReference type="OMA" id="GDVQRQE"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="352" mass="39502" checksum="94D60C8661259CBC" modified="2012-11-28" version="1">MSDLKTYLASKYMSGPRADAILAHAGVDKKKRRKKPKNEDYVGGSGSASGSGLVLMDEDQWRGSKRKADIDFDGDDAPVIGKDVATFKKGQSSWSTVGATALPVRTRVKSEPRDGESPIPSNPEDDSEPKPKQQLTKRRGGLRTAAQMAEEAARAAEEAKARSPSPEPDGAHTQTVHRDRSGRVLDVEQLKQEARREELEEKLKEEERKEWTKGFVQREDREAAAKELKKMESKDVARYVDDAEMNREMREVERWNDPAAAFLTKSKKSKSKGPRYQVYKGSWSENRFGIRPGCRWDGVGESPSDPGVHSCERLTSKLTPDRGNGFEKKWILAQNAAARREYEGNQMDMEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKU5</accession>
    <name>K1VKU5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Siderophore-iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKU5"/>
    <dbReference type="FunCoup" id="K1VKU5">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKU5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="InParanoid" id="K1VKU5"/>
    <dbReference type="OMA" id="WTHTLPG"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF55">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="568" mass="62247" checksum="00BC58E3DBD3C6DE" modified="2012-11-28" version="1">MRANETLTLAQNAAVEGEERKSADAELYDEKTDPSPPTPTEELQDGVRQAEAMTQSWNRASLITLYVFITWNLSAYITSEFAEHSLIPVISIVANVMSACAYMVAAKVLNLWDRSWGYLGMLVLATLGLILSAACQNIYTYCAAQVFYSVGFIGIIFAIDVLTADTSHLKNRALAYAFTASPWAITAYAGPPISERFYDSNWRWGYGAFAIILPVVGLPMFAFLRYHRAQAVKKGFDTKREASGRTFLESVAYYVVEFDVLGIFLLCAGLVLFLLPFSLAQSAAETWRAPHIIAMLVIGIVCLIAFAVVERFVPRPFIPARLLSDRTVVGACGLCFSWQIAYYCWASYFSSFLQVVYGLSISTSGYIGSIYDVIAALWMFPIGYIIRRTGYFKPVLLVTVPLYILGEGLMIHFRKPGYSIGWIVFTQILIAFAGSSFTSVQQVAVLAAGKHNDAAALLALLGLFGYIGGAVGNSISGAVWTHTLPQALQANLPEEVLPDWGSIYSDLEVQLSFPIGDPVRTAIQMAYAEAQSRMLIAGTAIMALALAFTLLMRNIKVSDINNVKGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKX6</accession>
    <name>K1VKX6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKX6"/>
    <dbReference type="eggNOG" id="ENOG502S5R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1082542_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKX6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="257" mass="27614" checksum="A54FE408DFEE4AD3" modified="2012-11-28" version="1">MASTLLTPFLVRAAGRDAASKQSIKSTCSHAGLTRPFVLPQQAYSPDSPFIRGYADTLPVPQEAFIAFIDSLNVAMCRSPEAQAVTVASFASMIICCSALTGWRLRELRRTRGKTDPRIVGTEELHTLLGMTLPASATVPAAPEDDEEDDDEDGDLYVTDAKRPASAQSATPSETKSSSALGKLTPYASLVIEPSTILPPVKVTYHGRNDVLANTTARTQAWRTQRKEKGAAKKAAKGKGEKLAKLHREALWDGCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL47</accession>
    <name>K1VL47_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL47"/>
    <dbReference type="HOGENOM" id="CLU_1200543_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL47"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="231" mass="25355" checksum="CC18A1C5C656A7AE" modified="2012-11-28" version="1">MAIVLVPASSDSEQDPRPTATDQSLLVASSPPPSPREPLVLVPPSQPPSPSPSPARTPSPPLTGLSALISFLTFKNGLPFAVTSQSLTARRLQWQDPMNLLLALSPPVAAKYGLVLAALDEPVQPIKCAWGCTCIPQLVYTAARFSCRHAIRAGWRTLIHVFYAADCRLGSCYYCAQHGTDCDLVAQPLCRIEQRLPLFFLSKAVVARYAVPEDYAQWHYFFELILVHKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLL0</accession>
    <name>K1VLL0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLL0"/>
    <dbReference type="STRING" id="1220162.K1VLL0"/>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080229_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLL0"/>
    <dbReference type="OMA" id="QEGHYDG"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="2">
        <location>
            <begin position="216"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="34960" checksum="010D5817A251A57B" modified="2012-11-28" version="1">MAVCRGHAEHTETLPAPVTGAICQQSQVALRFRWCNLHRIRPRPPLSSSPDRSPADTLHRLTTTTKKSTMRATRPLEQLLKYTLTSPSPLIRIRGSPKAPPTLAEDFAIYPSFFNEAECRQLLSIALWKLDRLDVTRKRGSRRRSASSAPAAAAATEDGAPLQDMFTGTYGFEEYREALISNYPPVAGDVSWLSRLYQLVPGLEGTTDVPPPNSSTHALHLSPEGEILAHVDNVEASGQTIVGASLGAARILRLEDKEDKQHGWDVLMPSGSVYMQKGDVRYGYEHSVLGYNHEGSHWDGERLKPGHRVSFMVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMC2</accession>
    <name>K1VMC2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000138">
        <property type="protein sequence ID" value="EKD05310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMC2"/>
    <dbReference type="HOGENOM" id="CLU_584209_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMC2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="506" mass="57363" checksum="8CB0CA383B551C87" modified="2012-11-28" version="1">MDNNTTTTLLLQLTSTLAQVADKKEPYQEQKWILTIIAFAVSGAAVIVTILSHIVSNRCWNMLSPTTKVNKRWHRPVRCDWLDDLPDFKLSLWEKLVTYRLMNEPQCLSLDAARALNFGKYMYDPGPRTDASGNEIRGTSYWKLLLGEPELRILILGDGFFIDLCVLACPPVLIAEPVEAGSEEWCKIPQHQLMTTAPNSLRCSAYTLAETINQARLLRSHDLLDVNPFWLEQRVGTQFPREVFEIKYEFIKITSDRIIDTGTTYGIRIPFAEYWCTLTTTRTKWSTFKHSSGSEGLVATSVWGTMPHVPSTTKFSDLWGDTPHGMPIVRREEANDSATRLLNLKERCKSVIECWEVQGAMAQGGKGHLSASDVNVLHIAELFKQWKEKDIPEMPEKHSFEYGYPEPAEPSGALTDHAAQVECKMGLLLSSVFSDPGQGVLRNIPKRLRYGIDAKPPAELKEWKQGVVVGCLELIYRIDSFCDDVRVIPDVAELIRPWEWRTAYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMH7</accession>
    <name>K1VMH7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000339">
        <property type="protein sequence ID" value="EKD00572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMH7"/>
    <dbReference type="HOGENOM" id="CLU_950576_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMH7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="293" mass="33750" checksum="A9A97365F7D5DDC3" modified="2012-11-28" version="1">MNAITTYLQKWIEEELEHVPYKPSELFSSNHDHAAAFCAKILPPSRTEHNIFVRNRHKPIARIARSSEKPSGFFASLSPPPYLFTTFYYTTSQGMRTSCSRSDLCQAYATLQSDLDDTYRRLSALRDVYALPFASAVAGPMVRFESTFGSRVRELERRCEAIMEREEWALDLFASYLAHLQHLETYGTLPQQWREYLGLDAEMVRLPHARESIWLMDGMDDYVFRAARLINTSSLPPEVRRLHRDLRQVAQEMMAQKGYAACVIERLLPPSSEKRRPQTVAPPAYEPPPPYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMQ8</accession>
    <name>K1VMQ8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_07799</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC98002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMQ8"/>
    <dbReference type="FunCoup" id="K1VMQ8">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMQ8"/>
    <dbReference type="eggNOG" id="KOG0962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006184_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMQ8"/>
    <dbReference type="OMA" id="NIIFCHQ"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="12">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="12">
        <location>
            <begin position="67"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="421"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="628"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="781"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="841"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1137" mass="129948" checksum="60DD74F16B4C5CB7" modified="2012-11-28" version="1">MSATTWEMNNIGEGLDVRSVDWIWAALNKLAIRGIRSFDDKHVQVIEFYSPLTVIVGHNGSGKTMANEKEVKAQVRLRFWNVNRQRMTVTRSLQVTTKKTGGLTMKTLEGLLAKTDGNDGKCSEMDEEVPLLLGVSKAILENVIFCHQEDSNWPLSEPAALKKKFDDIFEATNTKLTTQMREDIEEMIAKENAKQTEVERLNEVYQRIKEENFEFAQQATSFNTIFEHVTMLEKEKKMHESYRDTILEGTTILNDLKRQYENFDAHLNSIESKRDKQTELRDKEDHALRDLRRRENNLISTQGGLQANRKRNVKEREAVVRNLAKQHNFSGFDYSPLEDTKVADFIEKLQELVRKAESDLKRIQMDGVRKERELQAELDHLSSAKTAAVTTKQSKLDQILSSRIHHMEATFDSVSSVDADISVLANDLEASEQRRDRLDEEIRNAKYDDQMRERGAAIRQKELEKDKINAELSALNRQADTRAQLSIKRTEIESKTAQVDASRRERELQEAEATAAASNRTLSQLQTSLNIAKQSLQSKTGELTPASRPSRTPSRKRRRRSTSVKSESQVLIAPLTRSEIADTETSVKFYKKILDLGKTKKKCLGCDRAIHENEKPHFEAYRCSVGNMDEVKEELEQWQTELTSLRKHVPSVAQAKLLKEKEIPDLQRQIKEESAKLETVQTEVEESREVVQKAKLATRDLQNMRSAATVVTRTVGEIKDLKIDVQRLERDLQGSGSVKTVEEVQREREQSSLSSEKEFKSNALHTVREEISRKSFKLAELRTKQEKRRMDELALKEQQEERTKLQAELKELDAAAAAAIAPWREKTEAMERFRADRQSALDDANVQVDNYRSSATQLESKNRACQAYISEGNDRKLRENEAQIDDLRREIEATSATRAAIDKQVTALNDDISRASGTRKNIKSNIDYRGEMAKIEEVDKELASIDIEGAAQARRDFNKKYAELSQEETDAQGKWQLASGVLLQMTENRKKAEHLLKTEYRDIEKVYIDQLIKTKMGEHANADLDKYGKALDNAGQKVLASIIIRLALAESFGQGCGVLALDEPTTNLDQENINALAESLAEIIRERRRQANFQLIVITHDEGFLQRLAAHDVLEYYWRVSRDASQKSTLERQRVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VND6</accession>
    <name>K1VND6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VND6"/>
    <dbReference type="STRING" id="1220162.K1VND6"/>
    <dbReference type="eggNOG" id="KOG1851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293763_0_0_1"/>
    <dbReference type="InParanoid" id="K1VND6"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="2">
        <location>
            <begin position="702"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115151" checksum="2A79948624635CA1" modified="2012-11-28" version="1">MPLTAEVCTLADSQTTTPVQREFTQQQHSEQNAESDRFPSPHSGAVQPRLLLFLNRLDALGFVCVQPCRLVPRARAPAASGIALLLALPDRRSTPPPLYIPLSAHVVLTLYAALPRSYKPTTRPFYGHASTVESGFQDDDLDEDDELDYEEEEYIEIVDDTDFEFERNTVPPPLPTAAHSPAPATMPRTRRKDADALAFKRIAHLLLSAVQSKSRSSTSADDEPYYEDPGIMWSSNPDNALAGPYTTPSGKTVQSDPNDERLSNLGIPLALPYKVETLAEMDARLELIVCRLTECVKAKDWIVGFRWWQSMGYPMKRDLKIRLIFLYYEILFVPGLRSGFVEGRANELINWLNLTVNDLRIPWRPLYDALYNELFPHPNKLARHSVNLAPVYLNVAEAAQRLFHPADAEEMMETILPQFAPHMDSILATQLFLVHFLPTASCDKWLPVLFRLWYGLNSGLWDDQASDIIGQLAMVHIETHRSDPVLNARIPRGRTNTPEEQARNPSLKKAERNHRARILDAQNDVVDDADGLTYWVDPEKLPVEEEEGDPNYARLRRDVGIFTDEQFAFIMSKCLRSLNVPVGGSMASQNSMSITQADTRVSKKILDAKKPIDRTQSLAEVIIYSMSEDAPVAPFGTTGAPTRAATPAFTPHHPSSVDPITRVRNGDVAMSRTDSTDSLKAAGESIERSKKYLAGSKALDHLSRLITSCETFFHPSNAGPWSSFLTVFLSHLTSNFVQRWKMEEEPNCKVPVEWRLTPEIKRSFVLTLRPVALTAMFNKDMESAQPAISTLKRLALLEPDLIMPAIMERAIPSLQGLEETQRTASVTFALAAVAQPLAGRSVWRFGGMYVADILNLLLPGIDLNDPTKTGLSCMAICNMVDQIRIADISDNEATPNGDAGRTVRRVVRAKVDDDPNDPVGQEFEEMTEDEIESRLRISTGAFQDWVHEFLGRVLLLFANLPEEGGKTGRAGGRTEILTLQSVLHTCGAIFGALDDKLFDAGLDVSLRTQHCSTSPPHRCSLPRACDHASYPPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNG3</accession>
    <name>K1VNG3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNG3"/>
    <dbReference type="FunCoup" id="K1VNG3">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNG3"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_0_1_1"/>
    <dbReference type="InParanoid" id="K1VNG3"/>
    <dbReference type="OMA" id="PTEWYPP"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="242" mass="26157" checksum="7A8174B16D09D35F" modified="2012-11-28" version="1">MSAACCSLPPVQAEYTPKGSYGKLGGIKSYGVGPTDTGKAILVVYDVFGYSPQILQGADILASAGFRVEMPDFLHGTYATADMFDGSEAGTEKRNKFFSGFPGKYDTQSDQIGEALKDLKSQGYKSVGTVGYCWGWKATVTSSCVNDFAAIASCHPSFIDLEDAERINVPVLLLPSEDEDKKTNDGVYEALEKKNPGKNKIKWYPGQPHGFAAARGDLSGGKATEAYQDAYAELIKFFRTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP24</accession>
    <name>K1VP24_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP24"/>
    <dbReference type="FunCoup" id="K1VP24">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP24"/>
    <dbReference type="HOGENOM" id="CLU_033323_9_4_1"/>
    <dbReference type="InParanoid" id="K1VP24"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="210" mass="22763" checksum="8A33FAB14FA64510" modified="2012-11-28" version="1">MTVQLGYERVASLARGRGVEIVPNVFYFLRHGQTPRNALKIFQAYDEPLSELGQKQAVDAAAALANEPVRSIVVSDAKRTLQTAEPSAKALGLTPTPTPLLKERHFGALVGTSSETIDWDCKPEGGETLDEFVQRSLSGVEFALNRSEDQEPTLIVAHGGNLLVLVNALGIPLDRSKFSNALPLKFTRVDGQWHITPLLAPSDPAHANMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP42</accession>
    <name>K1VP42_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP42"/>
    <dbReference type="HOGENOM" id="CLU_991074_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP42"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31715" checksum="911D3111AF90481D" modified="2012-11-28" version="1">MPLIPTTIETLKADLARAPVDDVFLILSGTEDANGQSWCHYCNLARPDIERVFSSDDKCECNAFPVTVLTEDTLVLKVVRGELLSESMFWLASSLQVRGVPSIYRFARGGQPVAGWEDHPFQPHWEPASYRASDFGAYLDWWAAGVSEFEDFLLSSSSEPYVPPEQRVEALAQEWDEMKTIIAARKAKQEKDDAWRREKAEKAAKRKAREQRRASELAKAAEVNRPALAKLDPNVYGRQQVRAAALRRLRPTKGRLQYIKSVQRENTKVFCDGEVCVPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPA7</accession>
    <name>K1VPA7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPA7"/>
    <dbReference type="STRING" id="1220162.K1VPA7"/>
    <dbReference type="eggNOG" id="ENOG502RB55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311729_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPA7"/>
    <dbReference type="OrthoDB" id="2593364at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="989" mass="106439" checksum="31C5236CD8441040" modified="2012-11-28" version="1">MARETRGSARAAESPTTPQPDSSTKRKRMSADAAALQEANGGDNHDTKRARMANPNGAGDASNGNDVKTEDDGPGRPLSMDVREAIAVVIAQMAKSLPPPINNLLSLSLPPDFSRSDENTLGYMLKQDTLTWENLVSTIHLFTEHLLAPSSYPNPVPSLSRIHLPVPPLPAHFPPMTLYSFCTALHQILLQVEPLDDGSSPLDFTQTQERWALMQKTPGNGVGTLSGEWFTASVDLREVEAAKKKVKLEPGKTLLETFAETGQKFGYAKPVAVQTSGVLGEPDEKDVPKLSEVVIRRASLKAQRWKDILKARRTGSFDTTLHPVSVPRVSTGAFTPSFAPTYDSSSAAGMGYDSTLDAMHESARERKYLKESTVHNVPEEGWKGVLAKKPEEPGDKLEGEDEAEVKVEESVDDVLAANAERIEELQEWQELRVRKGDATWVSDREQAVADELFASLAKLRRSAAPGPRRCPSSSHRGRSQWDARGRPGADREQAVADELFASLARLVETSDTPPSALVDAKPGMAHTLAKRLLANRAPIIRGTLDPARPRALHDNSTIRLRAQAAAQINTQAPSALGLNGVAPSPHAPPPKAQQPYGQPQMREPPPHTMPNTPRYYPQQQRPAYGSVPAMSPPQGGQQHMGQMRMPYQGGAAGSPSYRPQAPNYPRTPMTPGAQNASLGGPVQSPMPQTPVGPGSPMQAPMQQQPMQSPMYQRMGPGPSNLRQSYMPGYGSPVQMRMMPQQVSPQVQAAMLGMPIPQQQMTPPGMTPGAMTPGSHGSMTPGGPSGMMQPQMGMQGQNMQGQGMGIGVQGMGQQGQQGMQQGMQTQGMQQGMMQMSPGMNMGMPMMGNPAVSPQPQQGQISPAQQQQQLMQPGMQMQPGMQGGMQGMQGQGQMMGQGAMGMMGVPMMSNQISNKPALASPNLEHHPSPFLAPAQVHANCSPGPSSTPTLRLREPSPAATPVNPVGRPPRHRYASRRKKKRTTPGLILDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPF1</accession>
    <name>K1VPF1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPF1"/>
    <dbReference type="STRING" id="1220162.K1VPF1"/>
    <dbReference type="eggNOG" id="KOG3272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076656_1_0_1"/>
    <dbReference type="InParanoid" id="K1VPF1"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="175" mass="19964" checksum="4FCD00F329EA6B4B" modified="2012-11-28" version="1">MVLFFTSKVTIYMGRDKVENEDLLKYGLPTDVWFHVDKLSSAHVYLRQPDEQPHGDWEHLPAALVNDAAQLVKANSIEVKIIYTPFTNLKKTGDMAVGQVAFHNDRKVKRDIRWPKNKLLEGDAGAICARALDRRPWRLAAPTVFNLRRAGRPRNADQLCGQIFVESEIAVHAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPL8</accession>
    <name>K1VPL8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPL8"/>
    <dbReference type="STRING" id="1220162.K1VPL8"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279156_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPL8"/>
    <dbReference type="OMA" id="SCFAQMR"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="617"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1130" mass="124390" checksum="016948432192B860" modified="2012-11-28" version="1">MRAEPPPTSSAAPAMTVTSSSSGSTQEHEVRVHGLGITDQDAHRRSRWSMTEAESGTSSSLYNLASPAGRRSMPENINGDDGIRSRHQSGVHHHDHPPLPPLDTSSALTHQLAPGSALPSPRPMTPSSPPDYVVAVVGYENVGKSTVIRRAVKTWGGSPVTTSYTPDGYKSSKVEFVEINIRALDKSGIGEVFPPGMSPVSGLILCYDAHRQETLHGLSEVIQYLSPTMPMVLFACKSDPDMPTEVDAQVGDSIGQPYNVGLIEVTTATKHGKHKMRTGLRWLLYRLEERQYHRSPVTDGSVTQDSPQTVSTERSASEHSTEEYSDAHSITSSFEKMQNWDDEDVASAQSTPTLEETNSKETSPGGHEEKVPDQPTVTTPTDSSSEPQVYLSMQELMNQLFTAIVSTENLMAEFVERFTEVEQYAVSRDIRLWALMKITSSLVLWTTRYPGDLADEETQNIFRDLLALMLQYSFLAHLTVELVKVEQSLGDVIDIDRSWACGSSAHHHPTTPTTIPPTTPADPDSSKAIELVVDKEHLYDEPEEMNGNLSVAHSHSMDKPTSTRSMSSSNLSVDAIGRPSEHSSSLSDSNSDLNRQLTADPHSQRWAAAINTIISMDAHVFAVELTKIQWQMFMNIRPRDILRHDLGKERDDPVGLSIEFFNHLSRWVSTMVLAHPKPKMRAKVYEAFVRIARRLRKLNNYDSLCAVIAGLRETSVHRLGQTHALVKLDPLIMRDFQSHLRLMDPRGGYTHYRRALQADATYGHAAIPLLLVSKLQAARPEDRRADGKIQWAKFARMGEIMASIPDFQARGSMVPGNATTAFRRLIEATPVISSEDVSYSRRLQTTNKQGLYERSKMLEPAGSHPQGMFRKLASLAFPWHLQWSTSAPSSPSVRFSDPRAFELILIAVVQLDSSQPQHSSTGPRVPAHSEKLASYQKPLALLPAGEYRNKLWLQTLTSRVLAFILCLGLEAHTEEFFAVLANPNLNVCRWLSRTFLPQTSHGPLSALEGRLHTQFAGQVSTSGDVPERELAPLSAVLTAPAPVASRAVSTWPVARYQDRSAQGAACPPMPGVQRLLGLSGRRPGAASKAHSGSSRDALSHLPIASDILALAASCARNGSPRRVELLAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ29</accession>
    <name>K1VQ29_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ29"/>
    <dbReference type="FunCoup" id="K1VQ29">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQ29"/>
    <dbReference type="eggNOG" id="KOG3217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_0_1"/>
    <dbReference type="InParanoid" id="K1VQ29"/>
    <dbReference type="OMA" id="YQQVTRF"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="2">
        <location>
            <begin position="6"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="198" mass="21774" checksum="1500BA1109FE0551" modified="2012-11-28" version="1">MAPQSYSVLTVCLGRSPMAEAVLLAEAKKRPNLDLKIDSAGTGAYHTGEKADPRWVRVERAAHINASWRQLVLHRVIADSRTISTCKQHGIPCPSIARKVRDSDFTDLDYILAMDQSNLQALQARKPRGSKARLALFGTFDPDLLLASPGSRKVRPAPIEDPYYGGRDGFETAYTQCVKYAKGFLDFLEQGGGDVPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQI8</accession>
    <name>K1VQI8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQI8"/>
    <dbReference type="FunCoup" id="K1VQI8">
        <property type="interactions" value="811"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQI8"/>
    <dbReference type="eggNOG" id="KOG1241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008296_1_0_1"/>
    <dbReference type="InParanoid" id="K1VQI8"/>
    <dbReference type="OMA" id="QQYQERW"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="859" mass="93409" checksum="E1427B142D974C15" modified="2012-11-28" version="1">MDAATLLTNALSEDANTRNTAQQQLEAAERDNFPAYLHTLANELANEQAQPHIRNAAGLAFKNALSARDVVNQPALSDRWMALPEDVRTPLKHTLLQTLGSPVHKAAFVSAQGVAAVAAIELPRGQWPELIGQLLEFVGNQENTGLRIATLQAVGYVCEVIQPQYLSARSNEILTAVVQGARKEEPSTDVQAAAIHALYNSLEFIRDNFEREGERNYIMQVVCEATQSPSSTVQVGAFECLVRIMSLYYEHMEFYMERALFGNPEEPVALQAIEFWSTVCEEEIEIAIEAQEALQYGEEPALESKHFAKAALPEILPVLLELLTQQDEDADEDEWTKSMAAAACLELLARNVGDAIVQPVVPFVEAGIRRPDWQGREAAVMAFGSILDGPSSQTLAPLVSQALSTLIGMLQGDSDLHVRDSVAWTLSRITELMLDVVDPSMHLQNLVTALVLGLQGTPRIINSCCAALSNLVTHLLPDADIVSEDAPPTSPMSPYYEGIFKALMPVSERPNNDNNCRAAAYQTMATYITCSAADTLPIVDQVAAAMLARQESLIGMENQLVGMDDRQNWNDMQISICALLQSFIHKSPALVMPYADRLMTNLLTILSSSGKHAGVLEDVLATVGAVSGALEGGFVKYMEAFSPFLFQALGSYDDYQVAQAAVYCVSDISRAIGEQLTPFAERIMVALIDILRSPAIQRQVKPTAITAIGEVALAIGPAFVPYLETTMGILSQAGSTAASTTDLALNEFVWTMREAIVDAFIGIMNGLKAGDPTPFLQYVPGILGFLRTCLAEEDRTEEFVGAALGLIGDFGDTYKQAVRDDICQEWVQQAISIGRQRGASRSSRTNAAYAQKAIKELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQX3</accession>
    <name>K1VQX3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQX3"/>
    <dbReference type="FunCoup" id="K1VQX3">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQX3"/>
    <dbReference type="eggNOG" id="KOG1232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="InParanoid" id="K1VQX3"/>
    <dbReference type="OMA" id="FDRTVVC"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="39309" checksum="76E9F04988BCFFBF" modified="2012-11-28" version="1">MNKVRSFDPVSGILVVDAGAILETTDNFLESQGFIFPLDLGAKGSCQIGGNVATNAGGLRLLRYGSLHGTVLGLEVVLPDGTIWNGLSKLRKDNTAQNVAAFAVSSYEGVQEVFADAKKYLGEILSAFEFWDAQAYTLVRKVLEENGVEREVFEEEGPFYCLIETGGSNAEHDAEDLMEKNKVLTGVLSQDDTQFKSIWALRELLPESCGKAGAVYKYDLSVPVGEMYEIVEKMRERLRERGLLKGDGAAGDPIRAVVGYGHMGDGKCREHLSPLIAGNLHLNIVADKYTDEIEQAIEPYVYEIVSEKSGSISAEHGLGVMKAPHVHYSQSDVSIDLMRKLKHLFDPKGVLNPYKYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR59</accession>
    <name>K1VR59_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="12">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_06402</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="12"/>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR59"/>
    <dbReference type="FunCoup" id="K1VR59">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VR59"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="InParanoid" id="K1VR59"/>
    <dbReference type="OMA" id="LDMKGPF"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC99202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="326" mass="35815" checksum="848B2E5A01B6D85D" modified="2012-11-28" version="1">MSADLAQKLQPHAKEIVIALGVILLALVLLAGKKKEKPVLDPVEFRPFKLIKKTQLSKNTYRASSTGSGVPYAFSTTSHGALRPGCASRQVRTGGARLPAHLIADRRYRFALPSPTASLGLPIGQHISIMANIDGKQVMRSYTPTSLDNDKGYFELVVKAYEQGNISKYLSKLNEGDSIMVKGPKGKFNYTKDLSPHLLMIAGGTGITPMYQIIKSSVMDPTDKTEIELIYANVDEGDIRESRGPGDSLHLVLREELERLSADSNNRFKLYDMIKERMHKAGVSSGSKVLLCGPPPMMTAMKGHLKELGYPAPRTVSKLEDQVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRT3</accession>
    <name>K1VRT3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor SPT4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">Chromatin Elongation factor SPT4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Transcription elongation factor spt4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_06339</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRT3"/>
    <dbReference type="STRING" id="1220162.K1VRT3"/>
    <dbReference type="eggNOG" id="KOG3490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1373073_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRT3"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000002">
        <property type="entry name" value="Transcription elongation factor SPT4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="18">
        <location>
            <begin position="95"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC99402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="199" mass="22127" checksum="3E1B6B509F8CB79B" modified="2012-11-28" version="1">MTPTSPSTIALHLHNKPVVVISRILCVYDTTKPFYTSLIGTHAGLRIEIPTDGSTYLPSQHYSTAARHTFLGPHPSPSPPLATTMPPKGARQPQLRACLVCSILQSQKDFVDYGCPNCEEVMDMRGSAERVVECTSTIYDGMIAMMEPEESWVARWQRIDKKKRGLYAVRVTGRPPQDVIDAIESRGGVYRPRDAVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSQ6</accession>
    <name>K1VSQ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSQ6"/>
    <dbReference type="STRING" id="1220162.K1VSQ6"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="InParanoid" id="K1VSQ6"/>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="8">
        <location>
            <begin position="203"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="612" mass="67480" checksum="82EDB5CB652FEB54" modified="2012-11-28" version="1">MVAWSNLSVGPPSPKTKLTLQRLGQLASILRLLILLKFLVKASRHVYAYGILGTAEQGYIALKNFVVRLALSLPSSQRQIKEQLGEVRKQLVQKLAPREFPEGVDLTICRELPANGRDIEWLRKEWTNMDKLNRGDVEKGRVSGAVYHGGEDLNTVISEAMAHYVVSNPLHPDVFPGVRKMEAEMVEMVLGLFHGKDGAGTTTAGGTESILMSCKTHRDWARAVKDRVIPETAHAAFWKASQYFKIKLHVVPVNPTTRQADVKRMKRFINPNTIMIVGSAPNFPDGAIDPIPELSALAQRYNIGLHVDCCLGSFIVAFSKGAGYGEADVKRMKRFINPNTIMIVGSAPNFPDGAIDPIPELSALAQRYNIGLHVDCCLGSFIVAFSKEAGYGDKIPKFDFELPGVTAISCDTHKYAFCPKGTSVIMYRSRELRRYQYYSMTDWVGGVYASPSMAGSRPGSVIAGAWAVLNHVGREGYLESAKQIIGAARHFKDEIRRRFPLDFEIMGDPQLSVVAIKSDTVNIYSIGDRMGKRGWHLNALSRPAGLHMAFTRLSAMSVDKLLDDLAECLKEEKENAGKDSGDLVALYGIGQTSVGPAIVDEFAKTFLDVLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VST5</accession>
    <name>K1VST5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VST5"/>
    <dbReference type="STRING" id="1220162.K1VST5"/>
    <dbReference type="eggNOG" id="ENOG502QUQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026011_1_0_1"/>
    <dbReference type="InParanoid" id="K1VST5"/>
    <dbReference type="OMA" id="YEITLAH"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="264"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="563" mass="62527" checksum="027E71E2D459CCB4" modified="2012-11-28" version="1">MSHEERDAALASLIHVLEPATYPLEDYDAALDRANNDVSRAAELLLLGMGEGSGSSEESKGRKRQRGIDFFMKPKPSLTSSPNSKRAKGNYTSRDPTPPEAPPEPFPEIDREAQKGAWSSLLKASAPKPRLASGPEPLKLPPLRLGTPAAIKASGIPVAMLQSPLSPQFAAQLYHVMMAESPKWNYNKFFLNGRECMSNHSSSTYSRTPKVFGIWRDYVLSGAPVEYFKMPPELEKAALLVEDAVNEYLDSVPRYPLEWRGRWRANMCGANRYEGAAATVGFHADQLTNLGPYPTIASLSLGVPRAFRVRPSASELDSGPVRTYEVDLTHNSLVLMTPGCQERYKHTIPPQKAIDIYRPQWDREGNPVPPEKQETYTSRINITFRFYRDGKLILHPEVDTQTSSQNTRPNVNAICPCASLRADQKGKVRAAYGIRPTSVTTVNGREIVDDGMVFFWQCQGSRAGKTECNTFKILDINAEGRGPCMRDPGPDFEPDEEQQPVKKEIDAKTEAVERVEPEAGRADERVSDRFKQDTGEPASSIVKNEPLKEELAVKEEPATPLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSV1</accession>
    <name>K1VSV1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitotic spindle checkpoint-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000365">
        <property type="protein sequence ID" value="EKC99722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSV1"/>
    <dbReference type="FunCoup" id="K1VSV1">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSV1"/>
    <dbReference type="eggNOG" id="KOG3285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSV1"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="16"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="225" mass="25037" checksum="3F90D412286C08D3" modified="2012-11-28" version="1">MATAQKQRQNQAITLKGSVALVTEFFEYSVNSEASTPPTSSGKHRLADLSADSRMVKKYGLPMLVTADEGLQEYIQTILQQVSAWLMEGALNRIVLAIKSIETEETVERWQFDIHTEDGPTQAGTMPGAPKIKPKKKTEKEVQGEIREIMKQITSSVTFLPILDEPCTFTILAYTNDKPDVAIPNTWGDADPHLIDRGTVEQVRLRSFSTNVHSLEAMVAYRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT71</accession>
    <name>K1VT71_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT71"/>
    <dbReference type="STRING" id="1220162.K1VT71"/>
    <dbReference type="eggNOG" id="ENOG502QVIJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017834_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT71"/>
    <dbReference type="OMA" id="FCGTNIG"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="677"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="273"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="800" mass="84854" checksum="34672653053772B6" modified="2012-11-28" version="1">MSEITARSIVTLVVFFVVNALVIWPIKIPIPRVLGVGYRRLIDGVEHLLGFGPLDHEGPIWGGNSDGTRQNAVTETGVTDAAESVPAPDVAPSGPGVPSAPASSEATTTVNGSGSGSTADAETTAKQRIRDKEKGIPRHFKLGLVTAPPAGVLLLLASTCITGRTVREGIVAEPIRPFDVMILFLSFAYIALSLDQVGLLRYLAFLVAKKATDHTAAVETPSATPGATPGQTPGPSGRATPTNSAIAPGATAVETASSETVAAGEGSGRARRRKGKSAQPVFAALYALFIFISAVAGNDPIVLSGTPFVAYFSRTSGSPAEPYAFMEIYAANLASAILVSSNPTNLVLSAAFGLSFLQYSAWMVLPTLAAAVVLYPVIALQYRSQLRRAIRPPDVDPRSALVDPAGAVWASTVFILAVVVLVVLSATGQLHGAAGVWSVAAPAAVLVALRDMWHDWRHRGQRGKDVELADLGQSGQNGASGERGERGVGQAGECTCSNGERRSYEEEEKEDEEDIDGELELHIVRPVMKPGMRRRLSSRVCRSRPSPAALAPLAALAPLAPLEASTSAVMPSTPSASTPTVTPGSSLGLGTSIPTPASSSTAASNTPRRRRTRRRRPRHHPIHWFRRTFPTVSSIVPRLPFPLVLFALSFFILVRSLETWIGIWARWWAIYVARTGLAGAIFMLALLSVVGSNFCGTNIGSAVLWQQVLVEWKRAARAEGGDVDQRILYASMLTLATGCNYGAYSFTFSASLAGLLWKDLLFARGIRVRIGQFCVNNLVPLSVTMLVSCLIIAAEVCVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTB5</accession>
    <name>K1VTB5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTB5"/>
    <dbReference type="STRING" id="1220162.K1VTB5"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_12_0_1"/>
    <dbReference type="InParanoid" id="K1VTB5"/>
    <dbReference type="OrthoDB" id="2587207at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="73"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="232"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="834" mass="91045" checksum="D94991F18CC23345" modified="2012-11-28" version="1">MTDSNFSLAPLPTSTPQTSVYPCESGTQHARNNFVPRTFTRVPSGVERGESLLHILKKYWGYSKFRPPQQEVCELSLKGCDVLVVAPTGIGKSICFQLPALTIEYGITIVVSPLKALMAEQVMSLREKGIPVAALNENTSRAEHVFHELKLAHPRLRLLYATPESLCRKDYQACFNTAHQQKQIARIVIDEAHVLYEWGNTFRPSVEAFVRQFPDIPKTAVTASATAEIRSEIARSLRMKRDGGNLAQFVLPVNRKNLFYECDVVAEKLNDSGITASPFYARMPEAQKSRALVDWKDGKISCIVATIAFGMGIDHPHVRYVVHADMPKSFEGYYQETGRCGRDGHRSRSREDATRAMSQANSTGMERANRQMLNSLKTQFAEDTTTCRHVGVCRYFGEIIETDPDTVKAYCDGMCDVCTNRAGVYLAAQHLTEDQPTLSPIEPLEPLEHSSPPAMTEQGTSNCTFAHLHDESQAGLQWTGVFSSIGPTGSGNGDARGSSKVDDDLAPLFDNPKSDTGILGTRDQRAHQTPLFDVPSSLPDNEQTRTPPIVDLSGSSSSHGKVGSKEGAPPSTVASAGKETMPPPRTAPRRAAPSILQALDVNGTRPPQPRAESSRQLSTIDELAEQGISGVVVIGAARSPGHAKRKIRDREETFKDVAPLSGDDAAFAFYNSAAPRKKSHVERLKFKTPGPALSAAAPQSSPLTRISTGDRNMLHGTPPPAASPARPVTDRKSGLARLLTALTVSLEKGDLADEIFACWNRDEVGEQRAAREVEAKIALETRHSGNYAIADIADSCKIARNERGVRLITSGKIRSLLDKRAVNFKVIEDCIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTB8</accession>
    <name>K1VTB8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTB8"/>
    <dbReference type="FunCoup" id="K1VTB8">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTB8"/>
    <dbReference type="eggNOG" id="KOG2206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010129_3_0_1"/>
    <dbReference type="InParanoid" id="K1VTB8"/>
    <dbReference type="OMA" id="SAIWIST"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="8">
        <location>
            <begin position="316"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="729"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="607"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="906" mass="97539" checksum="6C10F20BAB28C280" modified="2012-11-28" version="1">MASGNGSKSKGKKAASSSKPSSKPSSRAQSEGSPSAPGPVPNPSTDFAGFVDNMTKALEASTSAAAGFPDKSDLAFHRTLDRKFAKGLDATGQRVLDLTDRLLQLAVEGSQEKTKAAGGKVKPRRKVTDEDDVVDSFQATVIEPIDALLEDAVGSGCRTLLTLKDSNLDEVNGKKQKAAIDIKPSLAAKAGQKLPGPFSQTSQARLPTHLFNAPGIAKPQLLFQDGVDNSPDARWSPTLPVKEHAMVPLGHTISEDDSWPMGEMDDDPKKVAARREKIAKFEQHPYYYETRHLPYPTSMFTSSTPIRPKSFEDTPFEFIDTPEQLAALTETLKKAKEIAVDLEHHNQRSYYGFTCLMQISTREGDWIIDTLALRAELREHKLGHVFADPSVVKVFHGADSDIVWLQEDFDIYIVNLFDTYHATKVLEFPKFSLASLLQLYCDFEPDKRYQMADWRIRPIPDEMMKYARSDTHFLLFIYDNLRNALIARASRTPSPSVEGQTPKPNPQRAMRKVLDLSSETALKLYQRDGYDPVKGQGMNGWANLSKKLGKKDVMKEEVLIQLSHLRPNNASVLARTLVHQSAEAYARADEIAEVIKNAAAAFRARSPSKSPSKSLTPLSGTTSRAQSVVTATKKSTKAAGPVIDVWAGIGTGAGAPSSSALFGSTLTKKTASPSKNSQKASSSLFGSTLSTPGGGRSSRKASPGFNAVQSSIFSALAPAVAAPKVEVEAPGSSLPAPETVPFVPAANRKNATSDQIPTATTTKKSAQPAETTAEVEVATSAAPKATVDDDGIVSVKKKKAKKPKKASPSPVTDGAPGSGDAKSEKKKPAKKQKVKAGDIPTFSYENEANLLDEPAKAATNQRKAKKAKHDTKGDSKKKTGIDTSAFRRPAPDATAPKSGNRSGTFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV24</accession>
    <name>K1VV24_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retrograde transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV24"/>
    <dbReference type="STRING" id="1220162.K1VV24"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738079_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV24"/>
    <dbReference type="OMA" id="HARMSIM"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="375" mass="38261" checksum="99908E75FFA429A6" modified="2012-11-28" version="1">MNLIISHSAAKALRSSGRGSGAPSGSAGTGPGSAGGRAACFPKQLGPAWQSAATSVGGIGKARRALSVATSDVGAKMVALATDENDPLLANVERKMGRGYEQIAAMAGQAIASDNVILADSLGYQALNAKAAQDALSQRLQILDDAQSATKAAINKRRTVERLKASSSINPAKVDDAIADMDDANLAEQTLNHRLHAISNNLHQALRAHSRNAHEDMAVSLLEHARMSIMYNRHVLRELEALKPDFNKVNALATGQKVAPPVVGHAPPQSAAAAYASASTAAAAHSSASTPTAPTGPAPGSGSGTPFRSPASPAPATAQSMFLPTQSAPGTPGSQGSDPLGGGVAQSMVLPGQQKRPPPRRLDERKAAKLLAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVH0</accession>
    <name>K1VVH0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVH0"/>
    <dbReference type="FunCoup" id="K1VVH0">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVH0"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="InParanoid" id="K1VVH0"/>
    <dbReference type="OMA" id="REELMCV"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="109" mass="10861" checksum="98B408D6DF8CDBC0" modified="2012-11-28" version="1">MSEIQNLSLAALILADDAVEITADKLIALTSAAKLEIDQIYASLLAKALEGKDIKEMLTNVGGGGAPAAGAPAAGGAAAAAGGDAPAAEEKKEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVU4</accession>
    <name>K1VVU4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,3-1,4-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVU4"/>
    <dbReference type="STRING" id="1220162.K1VVU4"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026397_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVU4"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768210" evidence="2">
        <location>
            <begin position="16"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="113"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="673" mass="72144" checksum="E48FB87E74381BDF" modified="2012-11-28" version="1">MLATALLALASSAAASPLDMSKRGPERSLGWKLQATTGTRHGTLRPSTTRREAKPTMSLCPAAPAASTFEGSTALSAADGAEAEGAASHFSGLKQFGERTSASVGPATPLLHANWKHADNSYVNLDEARSKNLTWVDDQGRFGMKADHWSKPARDQGRGRDSIRIQSHERFFDSLLVLDLVHMPTGCGTWPAFWTIGTGEWPTGGEIDIIEGTNDQGNNQYTVHTTTGCKIPKKNNDDLSGNNEAFTGEARALDCSPVAGCSVDGSDPDGTTFGPGLNKAGGGFLVTRIKQSAGISMWWFPRSKGIPSVLTEGKNQVDEKELGMRIAHFPASDQCDLEKSLTEQQLIFNLAMCGGWCASRYQGAGHCQAKYPGKSWEDVIYDHPEEFNEAYWLINSLKVFQPCDECGSGPDTVPPPASSSAQQSSASPSPSQSSSESPSPSPTPESSSDSPSPSPTPESSSESPSPSPSPESSSSEQTQPSSTMEEVQPSTSTEDTSTQTLSVGETVTMDGKPWTSTWSTAWTSAWTSAWTSTYTVPAALPTDWKGHFNGGIYLPGEGGNGDGEAGAGDDGAAREKNEFQCLGQHQMPADDAWDEAYERWADEYQWHYHSQGNRRWKHKVLRGNASGASGASDAQSDESGKQEVQAEPAAETAEPVKRAQRHRRSWASGSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW93</accession>
    <name>K1VW93_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW93"/>
    <dbReference type="FunCoup" id="K1VW93">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VW93"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="InParanoid" id="K1VW93"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="36435" checksum="95EA505F89E124DE" modified="2012-11-28" version="1">MAYHSELSERLKSLASSGDFPHILFYGPSGAGKKTRIMATLRELYGPGVEKLKIDQRVFVTPSNRKLDVNVVQSNYHIELTPSDVGMYDRVVIQDILKEIAQTQQVDFNAKQKFKVVVINEADSLSRDAQAALRRTMEKYMTNMRLIMCANSTSKIIAPIRSRCLLVRVAAPTDDEVAKKERFTLPPSASDAIIEAADGNLRKALLVMEAMRMQNPDLNGDVDVAKPDWELYCAKIAESIMQEQSPQRLLDIRGKIYELLSHCIPPAVVLKTIADGLVARVDDPLKPVVVHWAAHYGSKKIFHIEAFIAKIMKVVKEAHFMGVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWN2</accession>
    <name>K1VWN2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWN2"/>
    <dbReference type="HOGENOM" id="CLU_1797807_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWN2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852139" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="14767" checksum="1D5267B0EBCDC1B0" modified="2012-11-28" version="1">MFKSLALVSVLALTASADLFNLKQIHDVSEKCHDHCGEVGNVISNNCTSLFKGCLTEFCKAASVKPCLECLKTEKMYDKFESVCDFFGKDTNTSSSSSAGPSATSSSAVSAASAKEDKKDNGASFAAPAVGVAAVAAAAVAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX10</accession>
    <name>K1VX10_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_01681</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX10"/>
    <dbReference type="STRING" id="1220162.K1VX10"/>
    <dbReference type="eggNOG" id="KOG4390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036207_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX10"/>
    <dbReference type="OMA" id="RAFRYQN"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000097">
        <property type="entry name" value="Potassium voltage-gated channel subfamily G member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="146"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD04007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="535" mass="59172" checksum="C47F3695B8A64225" modified="2012-11-28" version="1">MTSYPPSSSIPAEEFELTGPALAPTTSRTPRQKTLTLNPNSSSTLLFSAAPTTAHRRPRRTSSNPIKSGADSEGSRVYSRNHFLQDDLDQGATEEVHVPDFAHILGLHDPGEDSFNIASNMRSRWKRKLYLLMEDPSSGREAFFIHVTVTGAILFSVALTTMLTLPVFNTNPGAIKALFGLDTALVVLFTIEYIARSLAHSDSWSMYYNWVTSFFAILDLLSILPYYIELARQDDTSTLFRFSILRTFRLLRVFRAFRYQNQMLLTIEVMYVAVRRSKDALIAISYFIVLVLVLFSTLIYFAERGTWDPTLGAFVDSDGEVSPFSSIPETTWFCLVTMSTTGYGDVTPKTALGKILAVPLLLFGLLLIALPSFVLGRNFAIVHDAMVASAKHRSPRDSISEAGTPIQSSLTPIEEAESSSAPLLPLSARSAQSNSSSRDRSPAPGSGFHDGHPMQMPMWAGDASAGRSAPARDTRDLTNTKLAKNQYVLLEQIESLRKTIDKQGEMLEILTKALVEVKQDKGKGKAPEYDHEHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX17</accession>
    <name>K1VX17_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000317">
        <property type="protein sequence ID" value="EKD01388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX17"/>
    <dbReference type="HOGENOM" id="CLU_850429_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX17"/>
    <dbReference type="OrthoDB" id="2593987at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="327" mass="34978" checksum="A516957E14A541AC" modified="2012-11-28" version="1">MFKKLKAKANNIATSPTDKTGSALAGMQFKGGSNGKASSGPRSRPEWQCSLRPDPATGTANPFPARNGIFFLDAKVACADQTEVGNLLVALAEAGIRPVLVPSALKIVANVLKSRPKANVGARNDRSLVEAYLLDAMWAAKPTEEVVAKLNPALDMSWLEEKRYGLSDDVEAGVWLALVNGIDNLNPNGNKADIAQLAEHTKDAKLENQKQTSDRLTISHEIVTVCRNTLGPHMLFCSDRVLEASTVEDLGGPQLASRHIDIPDKSTSIGLRSKDAAKQLITELQNWKPMSPPVSPQAPVEPVRPVSPTSPEVATVEPVRAVSPMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXX8</accession>
    <name>K1VXX8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXX8"/>
    <dbReference type="eggNOG" id="ENOG502TKTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345878_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXX8"/>
    <dbReference type="OMA" id="CHYHEYS"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="562"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="786"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="895" mass="97385" checksum="D06FF0B8FD5524C2" modified="2012-11-28" version="1">MGKSRGKAAPKQPAPPSRLTKRQQDIADKVAPDSHKSSLRKAAAARPTSPAQEDSEDDDGQIKGEFGIWATEWMEKYKDDDPVWGSEEGVTNYTTILIFPPQPLEHCEDNLFPNAAALWGLSRHLVRKELDYSFMTKGRGPSCYIFPGSKKTPCHYHEYSFPFLYDPPAGLICANAAAAGCPSLIIRWDPVEGFIAACAYCFYTTKSNCSLILYQLSWCADRKYTKEESDAAKVGRSRNWKVPAGGMAEFLNKIQPIPAITSSSPSADSVSDDLEHDKRSSSHQGRKSSSVAYSDYDLSSDEEPQRRPKPSTPKKRSRSSEPEPSNKKPDHKKTPTPAPVSPLAGRSESTLRAEADDAARKRKEEEEMENNLMALREIEAAEALEQERLRLQLSDMTPELRNALSAMTTGVVDAKKTSEAPAPDRGASSLHPKPVNPDQVAAALSTFSGGLGKSADGPASTEEAARIVERMASRTPAPKADETSEQLSSSAGRISSNAEFIASRRARSVTSVKKLLSHLVDVLTEEQTKLEHDAQLDDNEVQDKLGQIAEDLLLPASIETTNKQLADNLRHAESLVQTLQGDVKQAVEAAQLKEQEMTALKQSTEVKLSNLATESQLRWENYNKLITATKELNTVKEDLKQARLDGQTLSLAWQEQQKSIRTLQSERADAVAKSNLAFKENQILQQRCAEHETSESALRAQVADLNTRVAALEAQNRLLEAHAREGSPLEKAGGKESRRKSVPSGFAPAIGNDVPTVGGAQQVTFPAPPGTVSPLELMNTGGGQTSSSSLVPAPSSSLAPAPSSSLAPASDDPAIKTLPAHSGFNCELAGRNLELGWASSIPVRYLLELEWASSIPFDGISNWNGPVRSRSTASRNHQVITPTPLVRSTQHEQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYW8</accession>
    <name>K1VYW8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYW8"/>
    <dbReference type="STRING" id="1220162.K1VYW8"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="K1VYW8"/>
    <dbReference type="OMA" id="WLEDATQ"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="293" mass="31262" checksum="F2BD9A53953DE73E" modified="2012-11-28" version="1">MLSRAHASRPPDSILKYVIVGDAAVGKSCLLVRLTDDKFANAEPTLGVEFGSKILTVGDEGKRVKVQCWDTAGTESFRSITRSYFRGAAGALLVYDVTRRESKSSHWLIISQVLCWDGNVAVLAALALVLTVAFEHVTSWLDDLRTHAEENCSIILVANKTDLCSNTPTALPQIQFGEAVSPSDVDPVDPEETPSTPTSPSAASASASDSNSNSASGSGLLPRAVSTLEGAFFAKQHGLLYVETSAKEGWGVVDAFEWTARQMLERIEQGQVDRKAKTVELGKGRSGAKGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ91</accession>
    <name>K1VZ91_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000298">
        <property type="protein sequence ID" value="EKD02083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ91"/>
    <dbReference type="HOGENOM" id="CLU_1138691_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ91"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="244" mass="26466" checksum="FEFB14776AD62D14" modified="2012-11-28" version="1">MPSATARVEADVMSACAFGEQHALSPRCYNRSFCRCRAGDFEDYTAVGFPNRFQDPATVRKALVPLSHLETSEDSSHPPKSASDRFPKPLGMPLGMLVAQILAVAVAASGAAATNLVPGTLEHNAPRGPRRLDTEPHAEALDKRGDWDNGYYGPAARRAFDAWTDTVFSFPTIGNYFVTASYVNYNIFCPHTEQRATYQGAEYVLYSFGCGALFWSKWPALGISSVNCRGNGGGSNTGASVYCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZJ2</accession>
    <name>K1VZJ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD04992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZJ2"/>
    <dbReference type="STRING" id="1220162.K1VZJ2"/>
    <dbReference type="HOGENOM" id="CLU_1662045_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZJ2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="17763" checksum="195FD8D53BC96CD8" modified="2012-11-28" version="1">MEKEQQKPKALAKVWAHASMTAALLHKKASHSSAFVLLESVYTTTEVSLEGRPGRGPGGRPQLDETCTFTVTLRFASEIDLVLSMRFCRKEERSTQEYAAVLAAIQGANVLLCDHPSKSFTPINAFFQFLWCEGLCAICQCGYCYKEWQPVVKVVILWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZW0</accession>
    <name>K1VZW0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA-nucleus export-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000291">
        <property type="protein sequence ID" value="EKD02353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZW0"/>
    <dbReference type="STRING" id="1220162.K1VZW0"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429713_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZW0"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="637" mass="70383" checksum="1403711A4F0CCDC9" modified="2012-11-28" version="1">MARGKGKNRKRSLDLSSVGEKTASAPSSGDEKKRRNRRKAKITLTEPEPTLDPAADFIDLSKSTPDIDYIDLSKSSPRSEAMDLGNELESDAKAAPAESSKQALERTPDAKGKSREPSFEIDTNPAPVPEYHPSAFTPMKSLLSSFVHKDDDDEAEDGEVVETGAKELQIGKGRNKKPILIDIDVEPHPETEAKLDGERAEKDEAEKEEGHAGDKSGLLLPEHVRLMESDEEDDPIEDSFVGPQDGVHVVDDSNAKLDEDEAAFLAAADQRQIARFGRHLTPSVPPVEPWMSMTGETVPGASCASGAASEDTENRTAPIQFRVLRGYEAATAVACAITWRTLEERDAAEGWTKEAVGGNPETKWCYNCAMDGHLGDDCGKRRGSLARPVLQSAFSEVIANRGPFASFPRRQGKHHRFDDLPEETSYSKFGGANPGRRGREKQQQRHRYADRRSGTDSDDWFSRRRDRSRSPDRRPWDRDRGGRGRDDRRDDRRDNRGGPIKFGRMSLPGSSGRDGKGGLLQQALHNGQKRRRQPSPRPMRDWDSDSNSSGGLRIRGRGNDRERDMEREWRASGAGGGNVADWGDDYDRMMRDRRDGRDSRDDRPRNGPFPLRSGGGRGGRGGGGGGRGGGQRYRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W002</accession>
    <name>K1W002_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W002"/>
    <dbReference type="FunCoup" id="K1W002">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W002"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018195_2_0_1"/>
    <dbReference type="InParanoid" id="K1W002"/>
    <dbReference type="OMA" id="IAGSIEW"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="6">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="5">
        <location>
            <begin position="185"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="36666" checksum="2FDF65D32BB073BC" modified="2012-11-28" version="1">MPSNTLSADVPTLGWWYGGQEPTTRGVPIWTKLIENMGGAYRARLEKDPLLVHSGLFLDTPSAFTNPTLGQVKENPTRYPLLQQAVEAFDGRCSCPVVHSKADAAVDFVIVIGHEKLTIELQRLLAPSGVKVVPLPKSGGVVDLDDAYRELAHSQQVRTYFYGEPALPSSLAGLSGSTVPLGLQLNPYSFQIPWDALHVLRVGEGNAAPTSALPLGSSHVLSPTRLTRVDPGGPAHVVRLLNTVLAIVRVDPEDRLETAKSKVKEEEGEKAEEEVKEVEIDEDEVPYREEIAQREVLGFVVITAIDTLKRKYTILSPSPGKLPSTVAIAGSIEWVDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0L3</accession>
    <name>K1W0L3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000107">
        <property type="protein sequence ID" value="EKD05357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0L3"/>
    <dbReference type="STRING" id="1220162.K1W0L3"/>
    <dbReference type="HOGENOM" id="CLU_752692_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0L3"/>
    <dbReference type="OMA" id="AFECECE"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF13">
        <property type="entry name" value="OS09G0290500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="368" mass="42919" checksum="6FFCA8DD3AE3867C" modified="2012-11-28" version="1">MVDVTFGTNYYNLPCLHVVGKTNLNQTFTSAVVSLPNKYEKTYREAIQAWKEHILLTTIPHLFINDREPGLNNAIRAEFKDIRIHYCEFHVERNVERHTSDAGQLTKKEITEFVEKWKNSVLHCSKRGDLEKGFNDLKNEFFTCHERLGFRGAFHYIYDTLRPDLEQFLSAYVNLHPHLGNMTTSPAEGTHATLKTFLEHKQPKLYKFIVATRKFMSSQYYSWTLAMAKQASKPTRGRHELLWQFDSRISRFALNMLPTSLKTLQTVFLLPCAHELARRLNDGTWSRYEFDPYWHVTTPDGMEEMITKLAAYDPERARNARQRTEHVDMPPIVLEPTVRPGAHLGHVNFRLSRSLRSLLPSEMIPPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1K1</accession>
    <name>K1W1K1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000061">
        <property type="protein sequence ID" value="EKD05637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1K1"/>
    <dbReference type="STRING" id="1220162.K1W1K1"/>
    <dbReference type="HOGENOM" id="CLU_1042767_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1K1"/>
    <dbReference type="OMA" id="PVCIDEA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="267" mass="29777" checksum="A4F21986F0923862" modified="2012-11-28" version="1">MMRFTETGPEFAIDLLSKHMMHADVDTYVAYSGEFFVRPRRRANGSAASSPTHSRETSATSVDTNGDEEEDVRNMLEPVPVCIDEAAHPLLDRKRTSTVSTVERPHGPRTVLGRVIVSGLERLGPNPTSNQPIITRTLMGPDGGGSTDPRDYELVIDNESGTYRPQVELLPILRKWLAANFVGLKVTAMSGMDPQLKSWKDDRKQKRKERLRGRIFAAEESDLSSVESDSDGDEGLPKGKHGKGYEFLADPKGTTKRKVWRRRKAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1P6</accession>
    <name>K1W1P6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1P6"/>
    <dbReference type="FunCoup" id="K1W1P6">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W1P6"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032677_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1P6"/>
    <dbReference type="OMA" id="IRDESIQ"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="76"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="241"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="592" mass="66806" checksum="9C385D5EE970E037" modified="2012-11-28" version="1">MADLESTHSSSHALSDEVEPERRETHSESGGQSFDDPDSSGDDAMADVVDVQADVAGDYGEDMLLAEGEQGGGKRVKAWVDRGTGHCKGVYDDHNDVALLIVEAEDPPPEIRHAEGAEGPGGFLKDDLLLNTRVSKEEKYDRQQGTLIVWTDHTTQQDIALSFQDVEGCDDIWQFIVEVQKHLSNQFGDDQKMAMASSSSPLATSPLLGSSTPQLGGMPRDEWQQPTLANIKDHEMWLRMQAKSAAGRERAVEHIIGEHYIKQLIGVLNQAEDLESINDLHALCSLMQTILMFNDNGIFEYILQDDIFMGVLGMLEYDPEFPTLKASYRAFFRQYSKFRQVVEIKDESIRNKIHQTSRLLYLKDVVLARLLDDPTFGILNSFVFFNQVDITTYIQSDEQLLHDLFVDFRTDDEGGNDAKKRDLVVFLHQLMVMGKGLQLANRLALYRTLLDRGLLFACEWAFRQREAVILHAGAEILTLAVEHDVNAVRLHVLREEEISRRTLVLEVIGLLQSTRDQGLMQQMIESLKTLLEGGQENEVSFWFKDELTVKQFARVKEMPVVETFTQYFYDLCAAQLFAPVSALPELKDLSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W341</accession>
    <name>K1W341_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_02423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W341"/>
    <dbReference type="STRING" id="1220162.K1W341"/>
    <dbReference type="eggNOG" id="KOG3905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021937_1_0_1"/>
    <dbReference type="InParanoid" id="K1W341"/>
    <dbReference type="OMA" id="FKHNVID"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD03313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56171" checksum="80F7C9DE42BDFB8B" modified="2012-11-28" version="1">MQASGLLTPRPSRVPSGSGARTPTAAGPSSNPADSADLWEDILRSADRAKTHAHKNIVLLAERHRGRTHLLDKLAGKRRQRPEGASALAIGYQVLESEDRDEDAAPPVSVFYPPSSHPTLLKLVDTALPPNPLPDTAVVIVLDWTKPSSMVRELLTWLSWVDGWAQRVSKDTDEMRDRSHLQHYAEPPAPGTPAPTKALGTTLLPLGPGTLTLNPAGVPIIVVCTRADQMDSVGDEMGMKGGSWEERTDWIQQVLRTICLSYGAALFYTSQTQPQTYTLLRDYLVHRLYTTPGASGEPVARYPFAHRANVLDRDAVLVPAGWDSWGKINVLREGFDLQRVHNAWESSINRSGQSTDADEEAIDDLWTAMVPDTERPKNRNDGAITTTSEGEQAFLAKQLEALMKDPNRDPRASFRHAVNSAAANEGEAPQRFGGVVGPMGAGGLNLPGVEKAMAEMEGGDDVKERFARIARRQEGKPQSPPNERPAVPNEALHNFFQGLLAKKSGGTPTQTPTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3A6</accession>
    <name>K1W3A6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsular associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3A6"/>
    <dbReference type="STRING" id="1220162.K1W3A6"/>
    <dbReference type="eggNOG" id="ENOG502RJAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391907_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3A6"/>
    <dbReference type="OMA" id="HISIFEN"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="658" mass="73865" checksum="9D4E1E6F635FBA5B" modified="2012-11-28" version="1">MYSLPSPFSWLLARTLGNFHPHITTRPLLDSFNSTPHTTPHTTHGPLRIPQLTLCDPPDPLKTHLDPQTARIPQPPPLHPITHPPPPDTQQPPTSPAMGLLSVPRWATRALSTAASPLPTTKLAPPSPLYQLIPSTVGAPSLSSSASDDSESTYATTDPDDLDPDHRSTGPSRQRGAPFARLDPLVVTAALLATGMFIVMFIWYPFPTTIHAFVAVAVGVVSWTMGSWARSLAGVVLRKPNLYRYSVPQLTGLAVASILTIYWLILGIHPPQEVAPPLNLDGERYFIAANLYNNEDIIPRWTGQIEKLIDHLGPNRTFVSVYESNSKDSTPELLRDFGDRLDAMGVPHRIISDVTERWWPYPTSPERIGFLANARNKAMAPLQSADSDTRLPDYDSYTKVLFLNDVLFTWEAAVRLLATKHDDDPDYDLACGMDFGASGLYDTWVSRDVCGTPTRPFWPYVKDPATVQRVRDEKVFPLAACWNGMVAFPTKHYLYQPGKPGKPAPAPAEPTRLAKRGWKMVDNSTYEGGRMSPALSEPILFRASGIDACDHSECFLFSYDLHRLYPQGSGGPKIWMNPSVRTAYEEHWYRWNNYVLRIPMVQWWVRNWSHGLPFEAVDWLWERLARHRDLCTWAALEKHAPERCPRLPGAKKNPWYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4C7</accession>
    <name>K1W4C7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4C7"/>
    <dbReference type="FunCoup" id="K1W4C7">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4C7"/>
    <dbReference type="eggNOG" id="KOG3143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_1"/>
    <dbReference type="InParanoid" id="K1W4C7"/>
    <dbReference type="OMA" id="GIPFFDH"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD03708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="21546" checksum="46C5E6B7B4314274" modified="2012-11-28" version="1">MVRQASVERKTGETAIAVTLNLDVAPGEKQAINVSTGVGFLDHMLTALSKHGGLQLDLQCKGDLEIDDHHTVEDCGIALGEAFKKALGERRGIKRYGYAYAPLDEALSRAVIDISSRPYFVGHLPFTREKIGDLSTEMISHFLESFAFASGVTLHVDSIRGTNNHHIAEASFKALALAIRMAITETGSNDVPSTKGVLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5B8</accession>
    <name>K1W5B8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic respiration-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5B8"/>
    <dbReference type="STRING" id="1220162.K1W5B8"/>
    <dbReference type="eggNOG" id="KOG4618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2741841_0_0_1"/>
    <dbReference type="InParanoid" id="K1W5B8"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="71" mass="8473" checksum="18C67D3F80603D89" modified="2012-11-28" version="1">MATPVPPNKNPTPKEYLPPPPTPEMKQPADYKKTLQAHKDHRVVSKCYEFFKAYRECKKNWQEQRKRDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W622</accession>
    <name>K1W622_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000419">
        <property type="protein sequence ID" value="EKC97218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W622"/>
    <dbReference type="STRING" id="1220162.K1W622"/>
    <dbReference type="eggNOG" id="ENOG502QS59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025989_0_0_1"/>
    <dbReference type="InParanoid" id="K1W622"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="738" mass="81219" checksum="AC83A108AA378685" modified="2012-11-28" version="1">MSAPIVEPVPARPSAEFSLLDKPDFEQVETVDRIPLSSTRVDERARSQLHSSSPMREIASSPDEARRQTTPSARAAVQSLEGQRATPPSMREKQAATERDLMDEEEQGTVVEGIEDDNLWVLLRMFNTQVNHVLHPARGLPPDQPDLRQTNLPNVPYRSDTLKANLERFIKAIAPPSSRGIREVQRLSDWHGEFYRTLAYCAGYFISWGLGCTVVAALCFFAILVAFPGTRRFLFPDLPEDVPPPDPLEHIKEEPLAKATPAAKDHKLTRAEQAEEHSVEVTAVMLGYIGKLLLGGEAREGNAVVGPKDLVAETDEPDNIVTDADGKIVGYQTEEHDANAERMRVNGEIVKVRRDKEARSEAQSEADARREELTTRMAKATENGVGGAADFIEIMQKALSPVPVYPDSFARFKLAALLVAPALLLHYVPAQLIGRVVTLLFGVVFWGHEPMMKGAKQLMERFPNWMDYLDPRNHLLSGVPTNAQLTLHLLRASEAEGNPLPLPPVAPTLEEANEAINDEEDGVKTKAAKAAASDTKAGKALSSGNPDNNKGVRKAAKKTGGKTKSLFKRAARKLAGMGSDVTVVGEESGVLKKKINSMVLKAKWGDEVPEGGFVAKHNGTSGHLFLDDEEGCLSWVPLLSKTPEKVWYIDDLVEMKKQGLGVQRLALAMMSGAEIESLGLALRFAKTADDVSMKDMTEEEQLAHAQRAEESLIFRGVEAREQLFNRLIAMGHQRWEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6L2</accession>
    <name>K1W6L2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6L2"/>
    <dbReference type="HOGENOM" id="CLU_017140_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6L2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="568" mass="60093" checksum="06D37D0F910159E3" modified="2012-11-28" version="1">MPTMAATPSTSTAPRLARGLHHSNPSLPHLNASSSLTPTSSSTHTVIEDRLAPLPPSANFSKSSRRVSSNNYSPLAPPRQRKAFSIQALPPNAFGFKHPSGTASSINLGQFNNSAVDLSSSAPSEPLLAGPSTLKRTPARMAPPPSSYSPPTHSYSSRMMRQKLPSMSSSSSSSASASDDEVPQTPNVNFLPPGAAMPSAPQWPKPMPTGKSGGLGITVPVAGVDLASGRSSPAFDEFEDAREFPDPEMASTYGSAYATPRTFTPQPSSQTQVNELHQQPAISTAPIAPTPNGQQMVPSLSSSSSTDDAGSLAGESMRTVSSNGSIPTTPTRLEFINSNFESLSNPTTLDELRNLRQVAKELEVEAQRLRRQRGGKPPSPKILPRKAVPVVSVTEYNELQQQQATKPPVPAARKAARMSLMNPVTVPTFSLQVDPLVSDEEDSSPLFAPPASRKAFYGLERSAMSVLEFSSRKSTPSPEENVPTFKPMQTMQAAAPLHVEERPALGLGLPPSPPEKSEAEQAKAKALASVPPSATANTTSGFRKFSRFLNKKKSMSISAAAAEVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1W881</accession>
    <name>K1W881_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W881"/>
    <dbReference type="STRING" id="1220162.K1W881"/>
    <dbReference type="eggNOG" id="ENOG502RTMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361307_0_0_1"/>
    <dbReference type="InParanoid" id="K1W881"/>
    <dbReference type="OMA" id="SEWYALG"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD05053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="845" mass="88469" checksum="104E3A791DF5CDBA" modified="2012-11-28" version="1">MTVNKCHQFCSGRRYAGLENGDECWCGDVLAPTDPGTNAGTKVDDRECGIPCGGDKEVVCGAPWRLALYESNLFEPEPNLCQPLLPGTGNGTGAVVSIDREVLTHSFDAAGTSASASASASASASASASAGTEVPMLLTHAGPGSLDATLLNGPSPGVSASTTPTSGPQLLTHAGPDPILDATSATPSATAATGSSSDSASSDSASSTSAILIDGTPWLTHGCVAASDARVLSSFAVLDQPNMTTVACLSLVGRKGYRYAALGLGHECYGGNVPAAEYGGSDECSYTCSDGRRCGGKWAVDLYQIGEGANASATAAGNGSMGPVASGAAGAAGAAGHVNNTLPPTSGTSASVNGTMANTTPIAPEIISGLAPPPPSSKPHKVWAHFMVGFTYAYTSHNWDVDIAAAKAAGIDGFALNMGTDPWQPKQVRMAYDAAKRAGGFEMFLSFDMNSLQCTTAQNATTLVEHVKAFAKDEVQAKWEGRVLVSTFAGQQCSFGRNETKPEVGRRDNATASTPASASASASAAATPPPPPPPVPDAWGPAFVDPLKASGIEIFFIPSLFLPPAQQASYAWLDGAFAWNSAWPGAANDTTSTTDSEYLAALEPRGKLYVPALSPGFFAHYGPDSYDKNWIYKSDDWLYCSRWEALIALRARAPMLEIVTWNDFTESSYLAPYPNNASLDEHSPAWVEGMDHEPLQALTKFYSDAYKTGSYPEIEEDSLVLWSRPHPKDATARNDTVPRPKDADLADDALYAVVLAKAPARVTIYSGKNEHAFDVPQGLSKIRIPSAPGTIGGFVERNGVKTTQYDSGGRFEYTDKPEEYNFNFYVGASSDPGQMIKSFVAVPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8N9</accession>
    <name>K1W8N9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosol aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000399">
        <property type="protein sequence ID" value="EKC98013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8N9"/>
    <dbReference type="FunCoup" id="K1W8N9">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8N9"/>
    <dbReference type="eggNOG" id="KOG2597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_0_1"/>
    <dbReference type="InParanoid" id="K1W8N9"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852784" evidence="5">
        <location>
            <begin position="17"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="6">
        <location>
            <begin position="378"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="6">
        <location>
            <begin position="540"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="695" mass="72834" checksum="CFB2C7C6207FDE51" modified="2012-11-28" version="1">MRVAFLLLTFLGTSAAFAPAGDPYLRHGRSLEPTGLFARENWGYDGSGHHPSVSVSSDKNTGADIAIIAAQSNAEGTPTILGDALNGDRAQQIQDAFKNLGFSGAAGSTVRIIGADGDPAKTLLITGVGKEVGPEQLRRAAGVGLRAATGSAEKVAVLFPTDGDDVLHAVAEGAVMGSYSWSKYKSKKTVPVQEIVVVSGGDSGVVDRASTLTKHVNKARDLVNTPPNDLYPENFAQMAQDAANAVGASVEIWDEDRLREDGMNAILAVGSASARKPRLVKVSYNPQGASKHVSLVGKGITFDSGGLSIKPTSGMWEMKGDMSGAAIVMHAALAAAELKLNTRVTAWLCLAENLVDGEGYRNGDVFTAYNNKSIEVLSTDAEGRLVMADGLVYPENFAQMAQDAANAVGASVEIWDEDRLREDGMNAILAVGSASARKPRLVKVSYNPQGASKHVSLVGKGITFDSGGLSIKPTSGMWEMKGDMSGAAIVMHAALAAAELKLNTRVTAWLCLAENLVDGEGYRNGDVFTAYNNKSIEVLSTDAEGRLVMADGLGIASTENPDILIDVATLTGAQVTALGERTAGLMGDQGAIDRVNAAKDHTGEPFWAMPFPEELRADLDSYTADIKNVGSGPGGMLIGGIFLKEFVGEGAKDKWAHLDIAGPAFNAGSAYGYQPTEGTAFSLRTLVKIAELINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8R5</accession>
    <name>K1W8R5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8R5"/>
    <dbReference type="HOGENOM" id="CLU_2672868_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8R5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852785" evidence="1">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="75" mass="7590" checksum="EC0BC32970F5A848" modified="2012-11-28" version="1">MLLSTLLSTLLLSGSALAHPSPLKQHPIAIALTTGNPTPTPSPASSFIVAVSAPATPTHAERHALPGVVTSTPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W996</accession>
    <name>K1W996_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000092">
        <property type="protein sequence ID" value="EKD05398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W996"/>
    <dbReference type="eggNOG" id="ENOG502RB7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031073_0_0_1"/>
    <dbReference type="InParanoid" id="K1W996"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="465" mass="51009" checksum="9BCDEEE63768CEC5" modified="2012-11-28" version="1">MSIKEIETRLPSPQETKRTQVVNGGGRYDPPSPSRPWQLADVLWQPLPQPGRSVPNKVSRPPGQPFHAPSHSLPGHLPSANGTQRQHPPNSPRRHRMDEYLNNRPQASPLRHSKNGSGHRRASSSISSLQFLQNDPYRGGSPLRPKQKGSGKKRSQSHSNLREANQQASVAAQPQHRPTTQDVDAARALTSMLGSVRSPTEGQFPPQAAAERGIHPRAMQLPPLHTSSLPGPFAPDMPPPRPRAQSFAAESREPFEHALGHERKRSTEYRPYLPPLRRHGGPTHSRGLSMDSSAAFRERFAPPPWPQNPDERYRERSGERGERYGSSERYGERYPSVERYGPGERFGGPERYGGYGAAFGYNSGPQGPQGPNQGPGGPPPSGGGPNGPGYEQYRVEEEPSMAGRGEEDKAAAELMMFLATSPSPVRGKREQVPSIAGTARVLFDDREPPPYPRPGPPPLSAAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAI9</accession>
    <name>K1WAI9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAI9"/>
    <dbReference type="FunCoup" id="K1WAI9">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WAI9"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="K1WAI9"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="255" mass="28243" checksum="E11A4C583FCFB9D1" modified="2012-11-28" version="1">MPNAPLQKPSEPILYVFDDVPGLQGSLAEFIKTAQDKAVTDHGFFTVALSGGSLPNNLKPLINEQGMQWDKWQVFFADERIVPLDHPESNYAACCKAFLDHVPIKREQIHTINTDLLTEASRTDPEGQHADKEADEREAQDIADDYEKQLISVFAVPNAVRYPTFDLILLGMGPDGHTCSLFPGSPLLAENDMWVASIIDSPKPPPRRITFTFPDLNHAQRCAFVATGAGKQDTLHDVLDEPEKGLPCSRVRPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEX1</accession>
    <name>K1WEX1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000348">
        <property type="protein sequence ID" value="EKD00119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEX1"/>
    <dbReference type="STRING" id="1220162.K1WEX1"/>
    <dbReference type="eggNOG" id="ENOG502QVV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015536_1_0_1"/>
    <dbReference type="InParanoid" id="K1WEX1"/>
    <dbReference type="OMA" id="KLHYWAS"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="179"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="572" mass="63333" checksum="5AD5820B81B31C75" modified="2012-11-28" version="1">MPATLSPFRYIQLARYVVQWWLETAPGLQARRKAAQARAAQIIYAPRMRKPLAQPKKEEYVTAAAGGSSAALAFKPTAVDKFEGLHTETELEDLPPYPDKYPDPRYPPENMDIYRLMNDERAFLPGSTTPPKEIVVLCHGLYGFSTATPIPLFPSLKLHYWASVLEVLRDRMGAKVVVVGVKGTGSIQERAQQMHEFLKSYLPRGVGVNFVAHSMGGLDCRHLISTIKPKEYKPLSLMTIATPHRGSPFMDWCAANIGVGSIAPPSVKNADDRIAAAAKYLPFTMKSPLLTREAREAEARKDTDAFSSFTSGLTNYLLNIFDSPAYHNLTTSYMNDYFNPNTPDDPNVKYFSVAGRVSKMSVLHPLWFTKLVLDSAAERGYPSTEVLPGHQYEGNDGLVSVASAKWGDFLGVVDGCHHWDLRGEGGLWPQHGAFKVEDEEARSGDWQALGLSGSGPDSNKKDPQLESSQQHDKDLATARAMSSPAASAEGSPKDKGWDLAHVGQLVDWVSDIFPGDKKDGQETRQYKDAKAEIERPEKEKGEGKTLKKVVRDKFDLARFYGGLMLKLREEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJA1</accession>
    <name>K1WJA1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJA1"/>
    <dbReference type="STRING" id="1220162.K1WJA1"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_0_1"/>
    <dbReference type="InParanoid" id="K1WJA1"/>
    <dbReference type="OMA" id="PYINNCY"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="81"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="499" mass="54805" checksum="91995AD065165FA8" modified="2012-11-28" version="1">MDRKDYYTSKGDVVDVDEKDSIPYEPERQPTHMTKDETIAKVLEVHEGGNYHHHKLGHHDRDVDRVRNIVDLIEDGERKYHKLSWWRLYIVMLVSAVALGTLSMPSVFATLGIIGGTITSVSMGCLSVYTSYVVGQVKIRYPQVHHWSDVGRVLIPGKGGVFLSRFMACAYVFFVCLAIGSHYLTGKAAFRTIVDDQAICGVVWSVVTLVVMFVFSLPPSFNEISWLGYVDFASIMAAVFCTLISTGISAHKKDWNTGWKATALPGTTFERGLVSASNAIFAYAFNVGQFSFMEEMANIEDYPKSIYALGITMICIHTSVGALGYVFVGPGIKSPALLSAGHTMARIAFGLALPVIFISGAVLCVMNGRFIMDKMYPNSVVRYVNTARGWAIWIAIIAALSLFSWLVSEVIPGFNALLGLVGALFNTATTVYGPSVMWFVLVRQGPCFGTRKNTILTLVNGFIIAIGLFVLVAGTYASIKDIVDYYNQVDVGKPFSCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKJ2</accession>
    <name>K1WKJ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromodomain helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1WKJ2">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WKJ2"/>
    <dbReference type="eggNOG" id="KOG0384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_29_2_1"/>
    <dbReference type="InParanoid" id="K1WKJ2"/>
    <dbReference type="OMA" id="GYKKVDN"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="344"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="649"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="894"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1293"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1192"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1324" mass="149284" checksum="7DECB623F24E4CD8" modified="2012-11-28" version="1">MQSDSDEGSSPLPVSSHTTASSNTKAPRQIILNAPRAASDDDLTPEPSDNGIDDADGEEELDMDSREAQTTEVQGRKERFVELPFTLTSAPSHFPSKRPSSDSSDEDYATKSHKKKFFERSGGNSRGTSTPDTAFDSDGASWRRGAARKVVTYNEASVDYGLDSEGDDDVMYYQQEARIVAMRSTLRTKRTFLKRTSFKKVENYIQKVWQVEQAFHNPAPDAKWKPSREDLEQYEIERERIRDLHESYKQVERVVGEKEEERDGQSVTLFLCKWTTYDEIKDQAQDAIQAYHERMARPTVPAKTQFYPIHNRPTYQKIAEDPEYLKCGGALKPFQLTGLNWLAYLWCKGGHGGMLADEMGLGKTVQSVSFLSYLFHTQKQYGPFLVVVPLSTINAWQMQFRTWAPDLNVIMYMGSAASREMIRQTEFGPLKNLKFNVLLTTYEFILKDRQELQQIKWQALEVDEAHRLKNSDSQLYEALQSFSTGFRLLITGTPLQNNVKGEWKIVITLTLELLSLLHFIEPEQFQLANDFELGDTEQEAKIKALHSQLETLMLRRLKKDVVKELPTKSESILRVEMSGLQQHYYKNILTKNFAVLSKGGTQSVSLMNVAMELKKAANHPYLFDGAEDRSKPVHEQVRGLVMNSGKMVLLDKLLQRLKADGHRVLIFSQMVRLLDIISDYMSARNYTHQRLDGTVPSDVRKKSIEHFNAPGSPDFAFLLSTRAGGLGINLETADTVIIFDAMARAHRIGQTRHVNIYRFVTKGTIEEDILERAKRKMILEYASDGGHINGTSTPKDKNGDFSKEELAAILKFGAKSMFQADENAQNQKLDAMDLDDILNKADNFDTEAAAAPGGTSSGGEAFLAQFAAIQDVKNDADDLSWDDIIPVEERVKLDEEESRALQEGEVGPRKRAAARAPGAYEGMDEADGEPAGSKAASPAEKKQKVAGPRKSNAQRAIELKEAKLTSKNRVVVIQTCDDVLTQAEEAVTNHKNELRAMQERGETISSSLRQKAILFTFRGIQGINAETVVARYYELKALVEHFKRVEDIENYAIPHDNLKPTMNWSVEWGPKDDSKLLIGIWKYGFGAWEQIKNLHDKIFLEDPKVVKDPNAPKAGIPGPIHLVRRGDYLCGLVREYEENRRMLIEQQAVIASMPVKEGFGYDHPPLPFSVSAKASSSSRGDKGKRRKTPEYTDSEDEESYESMDEDAVKELLRPAKRHLLKSGTDNLSREEKIAALKECVAGIGSRIEEIVAEKAAEGADSAKWRKHCWVFASFFWPRQGVNYSKLMDIHSKLDSSPVQKKPKTKRKGGDTDNIVKKRVKTEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WLR9</accession>
    <name>K1WLR9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WLR9"/>
    <dbReference type="STRING" id="1220162.K1WLR9"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398485_0_0_1"/>
    <dbReference type="InParanoid" id="K1WLR9"/>
    <dbReference type="OMA" id="PRMGTWP"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="70367" checksum="5C4314E28D22C55B" modified="2012-11-28" version="1">MSPSAAQAAPTPQPISAQPNPSRPVRKMSTSQHPLRLPSYSRGGASPMSFGAAMSGVSFTNGGGGFSYGKNAGDVPGSYGARFYGEGSDATQIPFSTSVSMDFGSFAASGSAFGLGGSSYRGRSYAAAVAGRDYSTANLSTSLASLSGLGSMGRSYSRGQIHDMMAMRSDAELTKEYECCGIKHSGLHALLEHVEDQHPYGVENQNTSSANNSAQNAIDLGFSPMMAMDLELEPDTDAAAPSGTNSTRSTTSPCPVPNYPLTPTTTNTNGTTAVRPDALTAQKGKGFALSFSDMLKSPPTENEVNLPTLMPSTTSSSPDNLPTPTASANPSPPFHAPPKITAASRSAFLSEPQRTGNQRLERAFNEVVSGNKPGAPEDTTQPPGPTAVAPGVLFTAAAAMGIPPAPPLGRQNGRDGTINPAATTTAAPAPAGGDDKKDANGKDANAAGGDRPKPAEPHLPPPSLFTTHKAWRCPNPGCNKAYKQSNGLKYHLQKGQCDFAIHDAIDHGLTLEEAEERSRPYVCAVGAGCTKRYRQMNGLKYHYLNSGEHGQYGLRMLQNGTHPHPPSLPPPPKRDRPNQNARQHAAPYNVPNHRATAATTTTAATNAAATGPRMGTWPTKPAQPTAGGVQRTAATAQPQNAAATPAAAARPAAAPKMAPVQRGRDAVLFANTEPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNY6</accession>
    <name>K1WNY6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_02989</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNY6"/>
    <dbReference type="FunCoup" id="K1WNY6">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WNY6"/>
    <dbReference type="eggNOG" id="KOG4777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_1"/>
    <dbReference type="InParanoid" id="K1WNY6"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD02759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="353" mass="38109" checksum="F73BE172DE118D59" modified="2012-11-28" version="1">MAREPINVGILGATGTLLSTHPYFKIHALGASSRSAGQEYAKVTKWKLASPIPEDVKKMVVQECKSENFKDCGVVFSGLDHDVAGDIEAEFRKAELIVFSNAKNYRRDPIVPLMVPLVNGDHLSVVRHQQKELGLKKGYLVCNANCSTTAVVVPLKALEVAFGPLQTVNVVTMQAISGAGYPGVSSLDILDNIVPLIGGEEEKIEWETLKILGGVNADDTGFEYHASSPLVVSAACNRVPVIDGHMACVSVKFAGKAPTPEEAEEAFRKYTSEAQKLHCPSAPPQDIVVHDAPDRPQPRLDRDLHKGACVHVGRVRDDKVLDLKFVCLLDNVRLGAATSSVINAEIAVEKGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP58</accession>
    <name>K1WP58_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000275">
        <property type="protein sequence ID" value="EKD02834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP58"/>
    <dbReference type="STRING" id="1220162.K1WP58"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319625_0_0_1"/>
    <dbReference type="InParanoid" id="K1WP58"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="389"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="594"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="859"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="996" mass="108159" checksum="EA6BFEF324CA2D0E" modified="2012-11-28" version="1">MDDYDDSSALLDDIFASVDAAENPDVVANSCDEESDLDEPKELPPTQTVPAITVAAHARFAGVPKGTPLRRPLGPATTTRSPALLRTPVSAQRAPPPTSLGGGGDYEYWMVQCDLDEPKELPPTQTVPAITVAAHARFAGVPKGTPLRRPLGPATTTRSPALLRTPVSAQRAPPPTSLGGGGDYEYWMVQCELYLSMYARLTGAETWDGDAFLRISGQRASLYSEEGKLFDKTIGGTGRSGPAEDETPKKTPVTIARAPRPAFKSPLLERPYSVPIQSSRLRGNSQSSEPPTSSPAVGPSTPHSATPKAVDRGSSHSKPAAAPKPVAPSSRPRATAKTSPKKKLHVGSATSGKDIEAWGGALHDPNAPGAVVMERPPAEEAEQRIGRALVVCPATLINNWKKEFTKCFAMRSCQPKIDLIVCDEGHRLKKSGGSKTSRMFDELHTSRRISEPRTSNGVLTTVLSGTPVQNDLGEYWAMANFVCPGIMGTYSQFQKQYENPIVRARATSCTQAVAEKGRLLSKECEDGNYDTPVPPNERLRTHQRKKDDEDDLDESELNMSVALSTVPRSRKLDISLSGECAAQVLTDAVGKLMALDRILKLVHATRDEKVVVVSSWTATLDMIEELCNMRKYRARRLDGSTPQKQRQELVDSFNRESRLASMVFLLSTKAGGAGINLIGASRLVLFDSDWPWVASTEEAGVHLSSAYREHDRREDLPATADEGGTVGPDDGPGCRDRRERFEGLKLTLADDLLECNCQGKGTVEQRRDSASTIMAEDSEDSDDDPMERSFVMASQYDGASERRKEARAQRAKLAALKEWSHVNALDYQCFKHLKDTLLHNDLSERATALPKIIPSVTIPANGEAADDPPPRKKTRRVISDSEGSDTEPIIADNDGANDSFNEDEDGGRDLPPIVKVEGDITDVSDDEDPPRPSLRVKVENGASREGSVASAGRKRRADSTESGNAIETYDLRELADQGHGGRVLFVFEKVAKPQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQH6</accession>
    <name>K1WQH6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endo-1,3(4)-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQH6"/>
    <dbReference type="STRING" id="1220162.K1WQH6"/>
    <dbReference type="eggNOG" id="ENOG502RGZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483277_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQH6"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853023" evidence="5">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="242"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="564" mass="61371" checksum="D7DF99BED0D20F1C" modified="2012-11-28" version="1">MYTTLLAVLPLLLTPVVESASVPLNNRADIKVAGRAIPEANRRLVRRVVRRGGDSSNCGNSTGVDNGGKEHQHKPSKTKTRPHWKPKPTGGHNHGGDDDDDDDDDDDDEDWNDGDDGDDDDDDKPTKTTKTDDWNKPTDSSSSSSSSSTTVWWTSQTTPWWTTSSETATASSSSSCGEWDWDCHHRSSATPTASATSSCAAWDWDCLHASSATPTASATSSCAEWDWDCLHASSSTSASATTTSSGNPPESTSQWQLVTKIAGNEFFDPKHWWFWSFDDPTHGDVHYVDAGTAWNDGLVSINERGNAVMKVDTTPYREKGKRKSVRIHGTRVFTGGMVLMDAVHMPTGCGTWPAWWQNGPNWPHGGEIDILEGVNDNTQNQVSLHTGPGCTMPGNFESGQKGVLHRGNGDFDAFNCGSAATFNQGCGVLDQSSDASYGESFNNANGGVYALVWADYAIQVYFFKRSDIPQDIKDGSPNPDNWGTPVANFPTTSCSPYEAFYDNFNIFDTTLCGDWAGSEGAWSSCRAKTGYATCSEYVANEGASFKDAYWEVVSVTYYNSTNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSJ5</accession>
    <name>K1WSJ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSJ5"/>
    <dbReference type="FunCoup" id="K1WSJ5">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSJ5"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_127_2_1"/>
    <dbReference type="InParanoid" id="K1WSJ5"/>
    <dbReference type="OMA" id="DAYDIDM"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="319"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD03954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="624" mass="68022" checksum="E34C87392B93C742" modified="2012-11-28" version="1">MSSVGAIEPSEEESMAGDNPKSSEAHVAARRPSASESADAHAAAALQARRAVADNPALLSPPLSTPRTPDSEAVSPGNISVKELATPLSEMQRPDMQRPPTQDSVAPQAGSAGTPELIPESAFLPGAKFRPLPAEAQGAMNIPPPSSAPMSRNVSENGTRQNRSQSTSSQKKGFLAKMFHHDSKVEKMTPANGSPPMTPNATDSDQSRPPSRAPSFKRTKEEPPAPDKLERRPSGIQRRLSERTTSHGSTGAGAIAAVPEAAPSKFTLKDLIGGGKDGKLSRRGSEKGSARGSDRGSTKGSEAGGENASTASLLKKYGICDRAAIGKGATAVVRLAHKWDRREEKLYAVKEFRKRRKNETEKDYVKKLTSEFCISSTLHHINIVETVDLVQDEQQHWCEVMEYCPGGDLYAAIKKGGMSSAEVECTFKQTLHGIQYLHSMGVAHRDIKPENLLLDGRGHVKITDFGVSDVFRMCWEKKTHLSKGLCGSEPYIAPELFEMKEYDARLVDVWAAAVVFYCMQFQELPWRVAKPTDATYATYTSQYYPSGARPEGAPACPAPLNNLVPRECRHVIKHMLDPDPKTRWTVDEALKDKWLQSVEVCVEGQKNNHSHTTVPLDVVRVTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSU9</accession>
    <name>K1WSU9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSU9"/>
    <dbReference type="HOGENOM" id="CLU_590772_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSU9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853057" evidence="2">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="463" mass="50140" checksum="B83984D01B3744AB" modified="2012-11-28" version="1">MLLFQSLIALLPIALGMAVELDTALHSQERRELHSWLETAQKGDTMRQGNTVYEIVQPHDAILAKRQGTGSCPNAQYEKREILGTSLDWVGPSPLPGGCMDCFNNQMPCHIARTVGWSISETVSVGMDLGLAGKFAEDITANIGFNKGYTWTKGWDGSMSFTCDTPAGKGDRVTVRTRVGVADAKYPLKDKHGLVVEAPRCETVDSLEACMIVVVAYRLSQRFTDERSSRHANAHRPWPERLEPTRPRSKPSVLPDLPAHGTPATGSKNAPLSQFVGKSDVCWRQLVLINGAYTEAGTKPGRGVDGGHHSAHTPIEEGYHHPACFLPADVAAASVPAHSPPPPLTDSPGPGSPRRPLNPPSPSLRAPAQLPMPVPHAATVHAAHATQPDPWALVASTAQPRLARPARTARPPHSTSQPSQHDLPSAQNRRPDEPAMHFRTKSARMGQFKTPDKAPMPQISWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTP2</accession>
    <name>K1WTP2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_01473</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WTP2"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_0_1"/>
    <dbReference type="InParanoid" id="K1WTP2"/>
    <dbReference type="OMA" id="CLAAQMD"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000235">
        <property type="entry name" value="Probable nik-1 protein (Os-1p protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="401"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="493"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="583"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="676"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="750"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1150"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD04254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1303" mass="140141" checksum="1D47C958B3E04B3F" modified="2012-11-28" version="1">MGDPVVVLPEGATAFEAHVLSLLSSFERQPSLAYAAPSTTLPKTEAQEAIESALFALARRALPGQQAQIQPNARVADGSSLNNSYKTPPPIDTTQCSVTCPSCGTSVQSPVVSVATPSTSFASLDISSSPRPVPNVAWINAHVNETGMSAEKELELLKAQVQDIARVCKAVATGDLTQKIIVPVKGQAMTELKDIINSMVDRLKTFATEVERVSLEVGTEGKLGGQAVVEGVEGTWRELTNVVNRLAANLTNQVRSIAKVTKAVARGDLSETITVVASGEIAELATTVNGMVMSLRLLAGEVSRVSLEVGSMGKLGGQAYVPDVEGVWKDLTVNTIEIEAEGEMAVLKDTVNSMVKQLTTFAGEVTRVALEVGTQGILGGQAIVDGVEGVWADLTTNKMARNLTEQVREIAEVTKAVARGDLNKTVNADVQGEILDLKITVNDMVAQLTVFAAEVTRVSLEVGTEGKLGGQALVPNVEGTWKVLTDNVNLMALNLTTQVRSVADVTVAVAAGDLSKKISVEAFGEILQLKNTVNAMVDSLRTFADSSVAREVGTEGRLGGQAFVPGVAGTWKDLTDCVNVMAANLTVQVRTIAHATTAVARGDLTQKVTGVAVSGEILDLVNTINNMIDQLAIFAAEVTRVAREVGTEGKLGVQAEVENIEGTWQEITSNVNTMASNLTTQVRAFAQISAAATDGDFTRFITVEASGEMDSLKTKINQMVYNLRESIEKNTSARQQAELANRSKSEFLANMSHEIRTPMNGIIGMTVLTLESELTRQQRENLMIVSSLASSLLTIIDDILDISKIEAGRMTMEQIPFSLRLAVFSVLKTLCVKASQNKLDLIFDIDPTIPDQLIGDPLRLRQVITNLIGNAVKFTTEGQVALSCRLKANKDGEVELEFCVADTGIGIKQDKLDVIFDTFAQADGSTTRKYGGTGLGLTISKRLVSLMNGNLWVESEFGEGSRFFFTMRTEATTSTREQVIERLAPWAGRSVLFIDTLGDQAGVSEMLLQLNLKPTVVSSPNAVWDLKQNVDGFPHFDTMIVDSLAAAEKIRTIEHLRYIPIVLLSPSNRPAGPENPSFIDLDESRRKLLALPSTMDQVLSPVPVKDCLDMGINTYYTTPLNLQELSNAIVPALESHQVQPGDSVKDTVLAILLAEDNVVNQKLAVKLLEVAGHKIEVADNGEIAIEKYKRRQMERKPFDVILMDVSMPVMGGMEATGLIREYEAVSGVAPTPIIALTAHAMIGDKERCLAAGMTAYVTKPLRRGDLLAAIAKVLTAKPQPVPQYNPNKSQQDDTERTLILASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUB1</accession>
    <name>K1WUB1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_01191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000223">
        <property type="protein sequence ID" value="EKD04494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUB1"/>
    <dbReference type="STRING" id="1220162.K1WUB1"/>
    <dbReference type="eggNOG" id="KOG3582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_576443_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUB1"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="334"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD04494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="474" mass="53396" checksum="96F51AB7B2DFC450" modified="2012-11-28" version="1">MSTSIPIPSVHYSGGGGTSPRSRPLPSPGSSSRSPSQSSLSSYRAQVAPYPRRPSQDERGEQGRERFLPPPNSGTPLHVLHERERERELRERELREREMRERELMRERERDPRDPRERDPRDAVHSRDGRDHLRDLDERELLLREREFRERELLRERELLRERELLRERELRELREYRQQQQQQAAGRPALPRAQSDRYSDRYSLPSFASIATSPTSAMNPSMGPPAHPSPPGGSPKGLRPSYSYEASSPRNAPAPLERERGCYRSSPPQAAEVSPPLRSINSLYAHEYAQPGAPMGGRARSHSASHRDWDQQRYYSPPVAAAPQPGPGGGAKSRRLAHLMSEQKRRESINTGFKSLRNALPSAIPTDSKAIILRKAVLHINYLQDELKKLSAANGAPTPVLTRGTSGNSAAEVDEIMEQDPEEEQDEIEEQDDDVAAVTPKVSNLHVKTGAGGKWEVETIENIDIDRKPNIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1WX43</accession>
    <name>K1WX43_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WX43"/>
    <dbReference type="STRING" id="1220162.K1WX43"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="InParanoid" id="K1WX43"/>
    <dbReference type="OMA" id="TYIRNSH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="200"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD05289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="380" mass="42526" checksum="A390372DF0B5241F" modified="2012-11-28" version="1">MPPSTSHHTLPPFPDDIPTAPLLTIHLSKLEAGDESESSRFFQACKDLGFFYLDMFGSALGERVVSLAEDVNALQNRWWALPNDVKDQYGRPHLHEFFAYRYGEVTGQYDANGELVRNQNYNLPAAEGWTVLTAKIRKDCVLGLDERLACHQMITDAQETLEGYMRSCHQVMDILFEHLEKNLGLEKGTLLEMHRLNERSGDHIRFTRAPAQPFNEVIAQQGEHTDFGSLTILFNWLGGLQIRRPDDGKWVYVKPVPGHPIVNLGDAMVTFTAGILRSNIHRVVPPPAPQDGLDRSSLVFFRRPENSVILRRLKGGLIDAQPPTADGPEMTAEEWWMARGTGKMPGIFTKNGFEPHVGGDLYAGQTAKFSQANTPPVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXD8</accession>
    <name>K1WXD8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXD8"/>
    <dbReference type="HOGENOM" id="CLU_1161856_0_0_1"/>
    <dbReference type="InParanoid" id="K1WXD8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="239" mass="26519" checksum="9E07FA28503308E3" modified="2012-11-28" version="1">MLRPQSGDTPLDLEHSSSSTEESGAGRVRSNGQLHSARLVPASLLCVISTSFGALRTSHHDWSDQEVNAWHPRRSHTLWRIPSIRTDSPLHTTIAIVCPGVCSGDNGSRYTRDARHAPYAPTSGNWYRTHLKWTHRAQPVQIPTDRTLVGRVSSFSGDDEMPFGVRVPAHFSGTVSMRSQKSHPTIMATCLPVFRQVEPLSVLPLTVAHCFPLPVELASISATVKLRKQWPEWAGFQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0G0</accession>
    <name>K1V0G0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hsk1-interacting molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0G0"/>
    <dbReference type="FunCoup" id="K1V0G0">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V0G0"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416781_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0G0"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="515"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="630" mass="70269" checksum="FB6493928D03738E" modified="2012-11-28" version="1">MMRDISNNNPSQPSKAVPGVNGVALPNGTPSLSSKHDPLKRTVLGRVNVNIAHNATAAAQKQQQHRTTRSQLAKAVPQPAPAHDVFEYDAGKTTTTSLGKRLRLDQQHARDQTLSKRARAEASQQAARHLEEQDKWIGKWRKAFPSLVFHFELGVEEGVGRGLRQRVLGMGARVSHLVVKGVAASPQKKAPSRRREGQSDNPFLDSTGATDLVTKAEKLGIKVWTVKNMLNKLAPVDNEKHDSLSNLLADEKLNGTRERDLSAPRPDYYYFRPGSKYLLVEDATARHRPVMIKEYTKELEWPIIHDQFLRLTTSSQLPPSVEHSKNLVRDLRERAWSLYVENTPFRGEEPPVPTLKRSNSLREMPVTPLPEELPYHDKASGNSVVITSNIASTSTANMTPNAFAPGGALALGANKDRAIMQMSKRVQVLKGNARMAASVSASKHEREAERERVSRRRSTGTETPAPAATKEFLSQTQVVNMLRQLRAPTTQTKPSYEERVRNREHVDAGYKRKDQDTASGYCENCRVRYNDLSVHIASGKHRRFANNPKNFADLDDMLQCLQRPPNPLMCVPTRVCRPCWAKHDKDARCGKCLDDEALFSSPKSTPGSTRQRHYAFAEGYATSEGSPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5L1</accession>
    <name>K1V5L1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5L1"/>
    <dbReference type="HOGENOM" id="CLU_721962_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5L1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="407" mass="44976" checksum="F81A3988DFCFDB61" modified="2012-11-28" version="1">MPAQTIIKTIASPFYDGPDGEPDWTPSFLAGEHPWQQRLAALAGMFYRYNTDQMQNDVMRLARSMLKHAEVKPRHRVIFRIAQPPARDSQRGMPNSDKESLFLDADRSQGPLCILVTTARHYQHHLGESVRRTRAMQALSDAAQALNLLHEADGTFLGLACVNNKFSRLFCLKSSNTFEFWRACDTAGPLFLLEVPEGSPMAGKVATLDAYCKLDVHANLAHTLVAKNLGPPRRPRDLAVNRTMATAVTANEDLTSLPKLSPGFRSRVRHFVASAQELVDPEQIPRSCSSHSMLNLPTSALSSLWNGADQGGSVSVATTSPAPRWYQRLPSFTKGQWSTIKAWAHGVRRGGRSNWDNSSNEVELENVRGEMLRQTPTFVLVDPSTMDSLVESAVQEVLAAAQVQTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5P1</accession>
    <name>K1V5P1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5P1"/>
    <dbReference type="HOGENOM" id="CLU_1246128_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5P1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="222" mass="24503" checksum="0C2A14B955E3D64B" modified="2012-11-28" version="1">MDRPSTRLPEFDWSSMPKVDGRKIAGRAHGRYDLTTGRTSTFHEMVSGSAIERKLTFNKITATQLGTIEVNLEGGTRQLSTLSGLPTLSPAAHHTIDEKLKKYATRPVLMLKDIIPTPRGEQEEPPALIAAGTKKEKENVKVKKEKQTKKRKSAGGRSGEAGPSRIPLGVAAAPHDDEIQPLETPSKKRKIHTVDLTNDRKPPVFINLLDSDDEDEKPFIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6Z7</accession>
    <name>K1V6Z7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6Z7"/>
    <dbReference type="STRING" id="1220162.K1V6Z7"/>
    <dbReference type="eggNOG" id="ENOG502QTWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="InParanoid" id="K1V6Z7"/>
    <dbReference type="OMA" id="MDENTDG"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="352" mass="37301" checksum="4248F0ABEF1F0599" modified="2012-11-28" version="1">MTAPLQTAITELFGIQHPVILAGMNVAAGPGLAAAVSNAGGLGVIGGIGYTPKVLRQVIGELKAGLKDPKLPFGVDLLLPQVGGSARKTNYDYTKGQLDELISVIIEEGAKLFVCAVGVPPKHVVDRLHKHNILVMNMVGAPKHVEKALERGVDIICAQGGEGGGHTGSTPSSILWEECVDRVKGKTSPLTGKPIYVVAAGGIADGRGLAAALMYGAQAVWVGTRFVASVEAGAPKYHKDLVVSADFGDTATSLIYTGRPLRVRRTDYVKSWETPDQVKKIQELTSQGKLPFELALAENPKLSIPGRPWLMGDVSARIRDVKPAKEIIDELVNGAKEALENGNKFIRNNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7G8</accession>
    <name>K1V7G8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7G8"/>
    <dbReference type="STRING" id="1220162.K1V7G8"/>
    <dbReference type="HOGENOM" id="CLU_1166558_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7G8"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27715" checksum="B192B5D8BCB41C25" modified="2012-11-28" version="1">MAGDDVWDGAVYLNKPGVKEAAEINGRTIKRALVEAGIPESKFPTLDVLEVGAGVGTVTRHLTGFHSVHSIEPSRSMISVLSKQVEGLDNVTWAMHEFGPTSAAQFDRGEEMPSPIESDPERKLAPPRKRFDVAVATLVAHHVGTLKPFFEGVLSVLKPGGLFILIEFRHGDDGEDISAVFHVKEEPKNEPVEDWDQGVITGNQFRTTPTKAQLGGLLTKYGFTGVGDMDGEGVPAFRLERGPVPTLVVWGRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1V949</accession>
    <name>K1V949_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_05195</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V949"/>
    <dbReference type="FunCoup" id="K1V949">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V949"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_6_1_1"/>
    <dbReference type="InParanoid" id="K1V949"/>
    <dbReference type="OMA" id="QCRIMAN"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="16">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="15">
        <location>
            <begin position="221"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="337"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="464"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD00530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="539" mass="59180" checksum="666B085CCCC87D42" modified="2012-11-28" version="1">MSFTIPANIAPPSDSGSDSASDDGGCSDWNSTLGDALCTQALFEDTVYPTAQEALAADAAKGFDLAAVSAKLGLDLYGRMRLINWIRRDKPTPADAAAIAKDDPKLSDDALLQPVLADDPLLQLEFDEDWSDDEEAPKAESSAEVEKLKAEIAALRGMLDRTMVEEVDTKGKGKVRDDDTHYFDSYAENDIHEIMLKDTTRTVSYARFILSNPAVFRDAVVLDVGAGTGILSMFAARAGAKHVYAIEASGLASKTRENIAANGLQSKITVIQSKVETVELPVKTVDIIISEWMGYMLLYESMLDSVLVARDRFLAPGGLMAPSQTRLVISGSTATRLQRERITFWENVYGFEMSNAMTTPYYGEGLVEVVDKEEVVTSDCIVRDINSHTATVAQLEFNAPFSLVATSGKTETVRAFLTHFDTFFSPIAGEAGHVPPHQNVHIHEFADDLTEKTVEPVNNAEANLVSFTTGPRGQPTHWKQVSFLLREPFELKPDQTVKGRFYCKKASCNSRELEIEIHYAVCDPGQEPETYKVHTSKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9X8</accession>
    <name>K1V9X8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9X8"/>
    <dbReference type="STRING" id="1220162.K1V9X8"/>
    <dbReference type="eggNOG" id="ENOG502RB99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708205_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9X8"/>
    <dbReference type="OMA" id="ADYWERD"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="390" mass="45817" checksum="9AF415B2D64B31D7" modified="2012-11-28" version="1">MRSPSPPYRRSRFRSPSPRSPIRFGPSRGGDRYRGGNDEYDDRPDRSERERDRDRDRERDRDRDRDRDRDRDRDRDRDRDRSFRNERWGRRGDRDRDAGRDWDTYYSRRRESRETREASPKSAASVSRAGSPEEGQITSPDASHGRRSPRRRSRSPGRYDRFDRYREFDRERRWDEREDRSRERERDRGWRRSRSRSRSRSRSRSRSRDREWERERDRDSPRRRSPSRSPPRRPPTGPRSDRAPPTGPRAYAAPPRFEPASRWGREKGTPPSGSATPGLHRDSPHAPAPNPYSTPHLATPSTEENTFEQRLLAELPQLKVPFKGAWEAELATYQARMAPLAQATLKAQAHMRSAAAILADAEAQRGEAGERRRIYLEQLHAGGIEGIMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAH8</accession>
    <name>K1VAH8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAH8"/>
    <dbReference type="FunCoup" id="K1VAH8">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAH8"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="InParanoid" id="K1VAH8"/>
    <dbReference type="OMA" id="ILCEEFT"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="162"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="536" mass="58664" checksum="A2FB1AB34F76F546" modified="2012-11-28" version="1">MTLEPNGVATANGNGAVNGTAALKAAVSAPAPVPAEGKAVDLSHHLSLVARSRMPSPLKDILTYMHLPGMISLAGGLPHPSLFPFQSLSTSVYHPSTVLDPANPVPPSDGITIDIARKAQPGNVSFLERDLQYSGAAGFKPLAEMCKALTAAVQPPAYADWDVLINCGSTDAWQKIVTLLCERGETVITDEQIYPSAQAAFIPEGVKCLPIPVDDQGMRPDALCAALDAWDTATQGPRPHVMYLVPVGQNPLGSTMQAERRKEIYAAACKYDLVIVEDDPYFMLQFEAWDPLAPSDESATPPADFMSKVARSFLIHDTEGRVIRLETFSKTLAPGLRIGFFVANSMFIERLLRGTEVQNQQPSGFSQVILGETLARWGTEGYLQWCAGLCEQYRVRRDWMLDALSSELALTPSAETMVATINGRKVLSFTPPIGGMFIWCTVHFDEHPGYAAFVGDGPDRRDKEHEFETAFWKKLVDARVLVTPGWYFTPYEGQGVPSSNNEPGKGYFRLAYSFESKEDMEEGIRRLANVMKAEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAK1</accession>
    <name>K1VAK1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAK1"/>
    <dbReference type="HOGENOM" id="CLU_071384_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAK1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="336" mass="36649" checksum="A9C0F42117CF15AE" modified="2012-11-28" version="1">MHMSQQVPFEAARAHVERQARNLVLDATYPLTGAILTRGCSSSHLSTLEARLDDSTTRSGAWASTSSSPPSQTSASAPHHSSRSQNEQLLPPNSNRQDPEANLPPFDARRANPPPYTRYDVHQPPRPPMPAALPLHGPYGSGSYRQPSPDYRPDPSLSGGYASDSSHVSSASGASYASYATATSARSGFSSSASYPRAYVSPPYVVGTGASMANVCYSSHGSHHPPSASTPSNHTYDPAAAQRFLASNYAPVPREQESWGQRRERESRNAAWRANMRMDAGGYAQYDWKDHAGPAQRHEWHQHTAECSESCAKSLDRREGVKEREWIRYGQGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAW5</accession>
    <name>K1VAW5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAW5"/>
    <dbReference type="HOGENOM" id="CLU_2238504_0_0_1"/>
    <dbReference type="InParanoid" id="K1VAW5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="108" mass="12483" checksum="2E5EA5E0E565767A" modified="2012-11-28" version="1">MFYYDKESFDRRFAFHAFEHTSFRAVLCLLTWPIVARRSYQFGLHGAPDDFPDITFIWPGGKMLPNIVASDVPLAPPDRELWLSTNPVLAAKVAKPLPEFRTLFKPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC19</accession>
    <name>K1VC19_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional regulator nrg2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC19"/>
    <dbReference type="STRING" id="1220162.K1VC19"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560414_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC19"/>
    <dbReference type="OMA" id="YHMARSH"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000286">
        <property type="entry name" value="Zinc finger protein 770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN RSV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="487" mass="50916" checksum="A203C038888FFBF1" modified="2012-11-28" version="1">MSTEASPQQATHLQSVYSQVPPHMTTAQDPQDRGYANAGQQQQQQQQQDSAPDSPAVQTPVTKGKNGATGPAEGKPKPHVCPICQRGFTTGGHLQRHQRIHTGIKAFKCPYPGCETRTSRQDNLQQHYRTHLSPTLRRGSGTAARQAVAAAMMAAGLKSSTSRQPRKSKNSQVGTPGSSSGASVTHGQSPYQTPTQATAPYGGYMYDATGQHGGYPPYGGIPPPGVSMANAQSAQSSRVASPVNGHSSASSVPSAHHQQYFGQPFAQPGGYAYPQYSQSQGGYRYGAPNAMPPYGAPPSQHSMYSGAMAQDHHQQHMYSPVSAGGFSAPHSARDSYGSAMAQGGYASQQVMSNGYPARQQTSTPLSAGAHEDIDPRYRSTGAPRALSPRRSSLTQQGDLLAASSANGASSSTAQASAGTSTARGTQQLQASAQSYSYAPSAHLYGSAQHSNGMAQPSRDGPSPMSYSARPSVASLTEANGSSKGEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCY3</accession>
    <name>K1VCY3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCY3"/>
    <dbReference type="FunCoup" id="K1VCY3">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VCY3"/>
    <dbReference type="eggNOG" id="KOG0321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_4_1"/>
    <dbReference type="InParanoid" id="K1VCY3"/>
    <dbReference type="OMA" id="TIRTWPL"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD01835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="378" mass="41912" checksum="A358407828C88582" modified="2012-11-28" version="1">MQTNDPDYLFQTTSELSNAERRERKLKAAEKVGDPIKVSSKVLDLLVDDQLAWTAESGWQARKINLATTMLYKGHKGPVTSVQLFKVAGETPWLALITSSWDKTVKIWDAAFTLQGHQDFVKSVTVLPTSPPTLLSTSSDKSCRLWDLSTLSSNEEPTTIQTIKDHTRPVDSAAYWIPEAGAQDNIIVWTSDSLGVIKRWNLIKAVGSTQTPMKFVEDLNTHDTSVGQLYPTEDGIWSVSMDKTARFHGDPSVVLKHPSYVKSLLPQPFGLPYILTGAEDEEVRIWDAANLQATKNQPISIVSGHCGEVTAIVPWLKAENGKSIPHVVTAGLDGTVRRWTIQELLHPPKLDYEPASQDSVALTEEEERELAELLSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCZ9</accession>
    <name>K1VCZ9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide lyase family 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCZ9"/>
    <dbReference type="eggNOG" id="ENOG502RZ0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680054_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCZ9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853704" evidence="2">
        <location>
            <begin position="18"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="3">
        <location>
            <begin position="228"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="451" mass="48228" checksum="4A9ADA9FB399DD09" modified="2012-11-28" version="1">MRFQLFSILAMIASVSAVEVNSQHEVRGVVGQAGPARVVRSYEHPHAAEPRRRRRHTKRKTTCKPKNNSSQAPASGDKPADNFVQLDASAPAASAAAPSASAGQTEAEQNEEAFEEAEAANPESTQPAAAEPATKEKSKTNKVNTSVLEPAKGVTKWTGTEMPSQDPLGSALSTFSTGGGGIGGSFLDMGGDTSYGSFAQMTNEGHNDGLKDAYGRLAVNGDKWTFTYRKGQVNDNDSWFWYTTPDPGNTGMDLTKARTASFTYTVQFENGFDWKLGGKLPGWYGGDSAEEAKHCSGHAGGPGCFSSRLMWRPDGVGEIYNYYWGSEQAYCNDPASYAIGTGQIICHSGSGDSLGRNSFKFEAGKPVTVTNTITLNTMNGDKPNADGKQSLIVDGVKVIDANNLVMRHHDQGRIRGLFFSTFFGGSGGSWACPKDQTATFSDISVSVLENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD63</accession>
    <name>K1VD63_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD63"/>
    <dbReference type="STRING" id="1220162.K1VD63"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_10_1_1"/>
    <dbReference type="InParanoid" id="K1VD63"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="322"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="494" mass="51666" checksum="FEEDE1B293BC5228" modified="2012-11-28" version="1">MSVLTGTQPNTTEATQVPDAAVAPTTAASDAVVQQPAATTTDAAPVADAPVVSPPAPDAAKTSEAVIANDQNAATSTVASETSKPVEGAVASTDATAPAANTTTAPAAATTTTTTPAPAATATETRPAAAAATTTPAAANANRGSKGSSTEEKAAGSSIAASSPAKSATTSSGKKRRKRGGLASIFVALGCLSADEFEDAAPPKTTQTRQARAPGRTGGLTSGAVQAPGSGSEIIHQHMLHRTESEHHLPHAQDLAHSRTDTSGGYTDLSDDNVDEHGQQEMLYGDEDFEDEEDRLIAQGGIGIPLDENGNPAPLLPPLLDMDKGRKCLVLDLDETLLHSSFKMLPSADYIVPVEIESQTHNVYVIKRPGVDHFLQEMGKIYEIVVFTASLSKYADPVLDMLDVGRVVRHRLFRESCYNHKGNYVKDLSQLGRDISTSIIIDNSPASYIFHPNNAVPVSTWFNDPHDTELTDLCPFLTDLATVDDVRGVLDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDD9</accession>
    <name>K1VDD9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VDD9"/>
    <dbReference type="eggNOG" id="ENOG502S20P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258289_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDD9"/>
    <dbReference type="OMA" id="WNRVRMI"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="876"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="711"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1340" mass="143781" checksum="0D5123D9931ADDF0" modified="2012-11-28" version="1">MSLPRVSPRRRKSVGLSERNLNNFDDDNLTLPATLKPKKRGVSMGGDLTSSRSFDGLSEKQRMRRAASILKLANPDEDNTAAYAETIDFGSLSKSRQSLGVERRVSFAPTTHEGVMKPRRKSSMGMMMSRNKQQHESPARPSLPSMPRRRSSIPNVQPPAPQYFVGEGEGGGEESMELESDDSANSDEILAQISAVSPAKSSDMSDSEDEMSMDETVIGGGIVQWDEADTEEDSDMDISQSSAATDDEEKTMDFTVALGEVVPVKAPQNAKRNRQSIGYSHPLEPGMLPVRPGVSDGPDNSAEMEMEETAIYGGIYGGMHDDSTISSNDSAGAEHTVTYTLGRMDFTQAGGGIVGRESLASDASFVTAGGMDFTEVGGGIIGRESTINRADFSYTMGGGMDFTEAVGGIVDEQTMAGQTTTSYTTSGGMDFTIAGGGINYQSTEVYGRTMNIFAPQPQPQQTPAPIPPATPKSSSSTRARSAIPDAPGSTPAAPRNPFAPQPATTQKPTMKNIFAPGTPAQATPAKKSTRRMSTPRAPTPARPQVTATPAKPPTRSTATPAKSPAPPIGTPGFARPTASSVKKTGTPAKSPAPKATPKPQKRNVFAPSPEELNGPPTPRTTGMHTAASVAKKLDFTPSSTKGTPNTTPASRIPLAASVQTTPLTLSTPGKRKRDEEDEDEAEEEAPSRKQQAVEAPDADSARSSTSEGRDSTSTIPTPTPSVPASARASPAPAPAPSLSTTTAGHASRCMSVAPSPVPEVHVESPALGPEAANEGEEDMEIEESEEVEMEEEDEGEEAEVEDNDREMTPELKPEDEDRPLPTITPTRRRSSVPRPSLGTPMRMLTAETAGMTLHPFETSRERAAAAAQDDAAAKTESDDDNAASGPVSLSEFLETVGVRFLDDLNPHVHQPRRSSVAPRGTLSAGEDTLSSFTVANAETIYVNMYDYGIDRMSSELAKSQEEIASSTRVCDADNPAVMREYYDSPPEERALYESTLRNFKAKALLQAQGEWYSWRLDVIERILPDFTAIHTAMAEEVEQHAVNHEVADTLLPDLAERHASLTVELEENKKQVAEILESDPTELADLKAAVVEQGEEITRFESELAQKSAQLGELEKEVAELERQEQEHTAALAVAKGMCDEYTSSDIRRLQSELSAMQALHGWRIVKTQPFEAVYANELLLKLDGEPRLSLMADAEGATDCLLSLAQGALRELKPASLAATVRAAGQLWTAASRLRAELALLELYYPAAFEIAEGELQCKARLMLPSAKSRADLTFAIGPQTLRRWPEPEAFAVPVHAEVKYGRARGERLEEVAKETLASAVPHVPGVLLQAHPSVPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDH1</accession>
    <name>K1VDH1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDH1"/>
    <dbReference type="STRING" id="1220162.K1VDH1"/>
    <dbReference type="eggNOG" id="ENOG502QS84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017785_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDH1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="534" mass="59285" checksum="FE4C1877C2B07F71" modified="2012-11-28" version="1">MATSASNTQRDITGKLVIQSFAADISPAGTPRLRCTRRARVVRRGEFMLPTDKCIKSVVFGDTENLWEVLWYPNSGVQGGEFASLYLSCVQEREQGINGKWTRKGLWLFRFDVKVMDERTNKMQTLCYKEASDHTFAVKTANWGWQQFVKRDHLFLHPSVVANDTFTIVCTISGQSLPPLGYRLGMAPPRQSGSTSSEAAIDTGASGGPKRIVPRDLVSAVGDMFDDPCELSCVGIELTAVYSDIEFDDLDDLLDTLSDSDVEDEAMNNVNSLFSSTTTRDEPLADMSQRIQPDIHFAEGAPPVNPAEIESEHGLGSADSVLSDEDMETRSQSMAEGDDDMAEESHEAAPRMPVRRISRKRMRERDEAAVIGPKKTRVVVKDAAWSTWWAILYWWLLERGMREGEGATGPRPVSAKSVYRLADKLDLPALKMRAFQHICSQLTSLNIPAEVFSRFSSTFDDVRKVAFFLQHWGEIKKSDTMQNIWKQIRGGKHVGFEEVGIGATAAQKAGPGSSGEEELVVRAVRAVHNEALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDI6</accession>
    <name>K1VDI6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDI6"/>
    <dbReference type="STRING" id="1220162.K1VDI6"/>
    <dbReference type="eggNOG" id="KOG4005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677957_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDI6"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF38">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="435" mass="45795" checksum="07BBD042E5749C90" modified="2012-11-28" version="1">MTNAVASSSSTSKRPAGAAPAGSPAAKRANTAKKPETDEASTPAPEGEHDDNNGEAKQPEEEMDEEARAKAARREARTIRNRESAQRSRNQRKAHLAWLEARVVELEAENRALRTGSAPSSPAKTRESSPANSVLSLASDLGIPPEIVTAGGGVNLATVAPPPAHVLEDIKPSIDPTAPPAMPEFPTPDLAAQSAPLPGHEQDVRAENAHLRWRVGMLENIVKQAATFFSSYNQLAGQPAPVAPNGLVGTPISSPAPGMDATLSPPLFPAHPREAVKSPLRLQTQLVNAAHHNVLPTPSSSDSSFIDLSNPVARHPAVMATSPAVSSKRRGQALQRATGSLTGINWDLPANRQRLDVVAKGTSGQVQNGTQQAQDGWFPEGTQATQWDEEMNDLLETLESSRPEGVAPVVPGGGAVGVAPVTGEEWAWEATMVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE19</accession>
    <name>K1VE19_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE19"/>
    <dbReference type="STRING" id="1220162.K1VE19"/>
    <dbReference type="HOGENOM" id="CLU_744310_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE19"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="372" mass="39754" checksum="0E26D6B62042B952" modified="2012-11-28" version="1">MSSPTKEETEKVDKSTPPASPSGAPKSGSPPPSYDVAKASPNARSSPSPAETPAVPESGVDKEAVKELSAMFPIIDAGVIEAVLESTGSKDAAAEHLLGMTDPSFVPDAALSERERQASLDADFAQALHFQDRQDHADRFPPPPRAPPYQGRGAQARAADASRRVRDTLAARLDRDEKPFDPATYVPPYQPRVRKPRAPRHGPSPYDGDYARAHELQQKYGEEDVQFTEFEKKVLHIAEQGKQTFSSLINRAKAKYDEFSDQRDHGQNPESSTARTGGLWGAPRPHDPHAAYAGATKPARWSPSELDDVEDAQPLSPRAVSGKISPPRSGNNSGTASPASPSGRPSSPGKIDLGESHSCAGTAKAHVEAHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE44</accession>
    <name>K1VE44_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE44"/>
    <dbReference type="STRING" id="1220162.K1VE44"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1367100_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE44"/>
    <dbReference type="OMA" id="INQTEEW"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046874">
        <property type="term" value="P:quinolinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF3">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="22486" checksum="F974D8385F723CDE" modified="2012-11-28" version="1">MPQPLRAAMSESQIPARPYDHERTRGSLVFITSLSSSSTLSHPLVPSRQDAAPANQLSQVARGELAPPQAPCNKCMYKGENFIVMIVGGPNTRTDYHINTTEEWFYQYKGSMVLKVVDEGKVRDIVINEGDMFLLPADKADTMRWLCPNTEAHGDELVVIRQCQFHCSDLDTQLKPHLDEWMANEDIRRCPKCGVVAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEA2</accession>
    <name>K1VEA2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">APS kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEA2"/>
    <dbReference type="HOGENOM" id="CLU_103816_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEA2"/>
    <dbReference type="OrthoDB" id="10502779at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="181" mass="19663" checksum="A163C77136873345" modified="2012-11-28" version="1">MSTDAHDTVARTIFLNGTVGSGKTTTATAIGSVLEERQIPHAVIDIDQLSTRWPSPADDPFDFRLTLANVISVAANYRAAGVQIVVLAGVIETMHQLRQYEEGLGVGGAIFDHVMLVAPPSVVKQRLLARHEDEDELQWHVKRAPELAMILDSAGLPGPTFDTNQPLKPLAQRIIQTVLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEY3</accession>
    <name>K1VEY3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEY3"/>
    <dbReference type="STRING" id="1220162.K1VEY3"/>
    <dbReference type="HOGENOM" id="CLU_877690_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEY3"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF108">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="317" mass="34093" checksum="5207FCA3F3966E65" modified="2012-11-28" version="1">MSDTRKAAHHGEDKWDGDDYLNQEGMLVASEANTRNVLAGLKAAGFPEDKLKSLNCLEIGSGPGAVTRHLLPLFGSVHSIDTSPSMLKTLSKQSFAQSDNLTWSLHALGADTAAAFKTALPSPKNGEDSSATPPRDQFDVAISTLTVHHVDDTKSFFAGAKALLKPGGVLVICEFTKDAEGNDVLAALREKYPEMAHGHAGSGQHDHGHDHKKETKGHEMHEGKHGGDSQSKGHIHDRGHAHAHGHAHHDDKVQSVNAPGHFHPSFEIGDIRKMLQEAGFTDIEGGNGEPVVIPKFKEAIPCIWVFARKPGEGWKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFA6</accession>
    <name>K1VFA6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFA6"/>
    <dbReference type="STRING" id="1220162.K1VFA6"/>
    <dbReference type="eggNOG" id="KOG0423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_5_3_1"/>
    <dbReference type="InParanoid" id="K1VFA6"/>
    <dbReference type="OMA" id="QPAKCGA"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="247" mass="27039" checksum="0A9AAD14FBC85D44" modified="2012-11-28" version="1">MSLTPTALRLLSREIVTLRKEPPEGVRIVVDEDDLSELEGWVQGPAGTPYEGGYFRIRFDFGPEYPNLPPKCTMMTKIFHPNVSKSGEICVDTLKKAWKREYGVGHVLVTIKCLLIYPNPESALDEEAGKQLLADYEGYCKYAKLLTGIHATPKLPPAPFRDAKARPTSTLLPSPPAHTPATASPSPQPPSPHKQQQAQLDAPRPAPLGTYARQETSPAPPSVPEIKKTVPAKKPPAAKAKRGLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFX9</accession>
    <name>K1VFX9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFX9"/>
    <dbReference type="STRING" id="1220162.K1VFX9"/>
    <dbReference type="eggNOG" id="KOG2428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685472_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFX9"/>
    <dbReference type="OMA" id="KEMYDIN"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44241" checksum="4E3A47A685EE03F2" modified="2012-11-28" version="1">MSSDNENDLWGESSPPAQAPSPAPATRHPDPDEEEEPAEEGGGDICAIFPRGIREPARVPGRGRGRRGDAGGVGECAAPAVAAPEAYRRQGLAPQAARDDGDLKPVEAKSKMIGVRNTIRWKWVNGPHGPERRSNARMLRWSDGSVSLQLGNDLFDLAPSYGSTLARPQDAAPPAAAEAGNAETSFLCYTSHHEQVLVAETAIAGQVNLVPTSMDSKTHRELVNHVGQQHTKHSRMKILDDIGDSSKVAELLARAAPQRPVATKRPSRPGANKYGGPGGRSRLKRADSEDSGFGSPERRRREASYDEDDGFVVADTDDESDSDRRRKKKRRDREEDLDEMEIAERLIEERERARKKAKKNKPRRKHKTYSSDEDEDEEPEAEETDDDAEGEADDMDVESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG14</accession>
    <name>K1VG14_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC98006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG14"/>
    <dbReference type="STRING" id="1220162.K1VG14"/>
    <dbReference type="eggNOG" id="ENOG502RSBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281895_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG14"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="6">
        <location>
            <begin position="638"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1081" mass="116355" checksum="C709B8E3B5D8389A" modified="2012-11-28" version="1">MLQPDPARSLPHPLILLHAPVRATARNRKLVVDGAFASVPGSSCRHLGEGRAMSPSHGFKCPSSNAGVNNDPPPITRRHRPAMSRHQHPLKSVAAHASPAGSSSAGADARNTLAYDQLTPGTGFPTGQLTGSLKLLYTPKPEEDELHLDFAIKVKLAASSDYVQSKQHRRTIMVRFILLPSPSDDAALVAQARDANYDLLKRSLGSTLTVDCAGAKVLGRGEMGDRTPVVKIRATGSRVVTVDGIRHEFLKCERPKPSSRSRADDWFSPSPAPSVPSAPPMHPTTAAQTELTRGDVTRHGGAVPAMRPLSAVPQFTIRSEIKAVHAAGHASASTSAPRGSERRSPLRPLPAPAPTPAPALAAGEAAVDTSASIHTVAQNTTDTVRDPRTTVNLSSHGPGSVAPPHAPASPPFRPLLPSPSTVLSSRPETVDTPPSSMELAKGESGKAKLNLDPAAGESVTRASTREGQLGWSSPGTRPTEMSENSETEDSYFPDKQLSAIEMEAKRRTLLAAASAAGGAEAAAAQVESRSVAPAPALQQRRAKRPRDDEESPAHAGQKKTRIDHGEQHHVQPAAPLDPRREAETRAAAEASALRMRQAQLREAEAALAQRRADAEVLHRGLQVHLSADFQGRSIPRTYVTLREAASRSSANVAAVIVDVKGMRTTPTGDRSLTVVIADPSSHTQGNASEDMVVTLFRKTEAPLHLLSAGMPILFRALKITTYNNKAKGQMYSNGSCVLYALREGEVVTTDTSGEGLSPQEVERLQQLQQWWADNGEAPSTTNAAVGDSNRGRQDVELGSIKEAQYFQLTGKLNTRGGNFPKYELYIADGTVSGDEVRDFHGVGNRYPWLPRGSIFTLAVQNDPVGPAFAPGQIVRFPNVRVKRYAGQLELIWSDKVTLQQERDGWKSRRHFLVPGGDERAVIIEKARDRDTPEDDPHRSDPAPAQSLAEEPEGESDRAEPISDPDTYCKSCEDTGYKHAEVRWQFVLLLEDEVGGELVVVMSASRILPPLPSLAHESSSGIGKLRATAIPALRPKVENILQGAMFDGARTRPWIDMTLESYVVNVQEGEVVAWRVFGMETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG88</accession>
    <name>K1VG88_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG88"/>
    <dbReference type="HOGENOM" id="CLU_742244_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG88"/>
    <dbReference type="OrthoDB" id="10683502at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="373" mass="40328" checksum="D85C69AC3C028D61" modified="2012-11-28" version="1">MSTTPSPSASPSPSARSVWTSRTVLSTRKTQPVAGPSIPLLPAAPQCQSPRQMGGPLRRSRARHMRLCNPHEYGLFTVSEAEEIEAAERSSSRCPSWLSTRSSASDSSAPIHTPRSETEDPFEFWSAICDEPPVPPLPSGAVGRKRPPPLDLAPYPRSSSRLPRVSASEPAGVKAPLLPALPIRSPLPGAPKFAKQPEPEVPIGLGIMAPNGVNLVSALRELLTSCGEYDEFSHDEMFADAEDDDESMASAPVTPTTPVTPQIAYTIPTPRAPRAQAPREHRNAVLFGDHTYLQSLSDSCTDAEEDAFEVPSLSNSWNSTSSRTPNLSTPYMDEPLHVPVVPMAGSLYSMPNVSLEDSKRMSSRSSRPGWRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGG1</accession>
    <name>K1VGG1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGG1"/>
    <dbReference type="HOGENOM" id="CLU_729953_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGG1"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="37411" checksum="F58F603CD9BBEE82" modified="2012-11-28" version="1">MPTRKKQQEMKGQKLDTEPPMFSSNIAGIMALSPQTKYESGNFNSEFTTGGDTFPIERLNITDKVLDQSDKSLNRKLWESFPVNKHLDDIKKMGQEAMVQTAMAMHMGNANIAELLPVHARDQRAQLFIIIYGVCSFIEGEQGSLLASVMQDIAVRKAKNRIDPIATVVAEVEAKKDEANDLFRSINLAPNKDRRTVDALIAYIRALLALAPWYASPLVFSGKQAFDFGIAQLQSALLLNIAIACQYLGGADPRFYRKAMQFASLIIEMRYVKHKTLMKAIQILNSNRDELCRIVGESPGAMPRIVQETLTKMEAKAADGWAHENCRTAKHEGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHD3</accession>
    <name>K1VHD3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHD3"/>
    <dbReference type="HOGENOM" id="CLU_537687_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHD3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="507" mass="56815" checksum="082E85B3ED4E4856" modified="2012-11-28" version="1">MREDELDRLKAKRDRALKAIPMDTTPSVPPKSPPPSRPRRPISPPSAYPLSPLMFTVVDTQIPLRSPSRSETVETLDAAVDFTRAARLARAPSVTSITSSVAHSDRKASMTRTPPTTAPSSPTMSDIPLSPMSSFSAGDTRAAARAKVFNSVLGVDVEVLVIILSLLINSFQHYIWLGSIVVMDQRNDAEQALQALRLRLLAILAQEEGGPQSDEADSRLHCLYCSTPSRSCRAPHRQLPPSAARLRHAQYCILQACVSPTIRTPLMTENGIMKCPEPHEYLRPEKWTTKFPPEQAWPAAPAANRSGGEENDAERRNALRAGSIDRHSRYTAPAHHHQPPHHQRIPGAHYLPPIPYRHYFPEDDANHIRDRRDHRGHRDHRRRREPLEPGEIREHRPPRPAPYHLPNDRNEPRNQPDRLQWRRNPHPGDYRPRNNHHAYEPRDHYRPPPWDERNVPHARHPPATTSATANAVMATTTGATANTVPAAKVRVAAPLPPPATTIAADFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHE4</accession>
    <name>K1VHE4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHE4"/>
    <dbReference type="STRING" id="1220162.K1VHE4"/>
    <dbReference type="eggNOG" id="KOG4759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092155_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHE4"/>
    <dbReference type="OMA" id="WFRKEVA"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="6">
        <location>
            <begin position="117"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="264" mass="28350" checksum="3DD01C031ABE0CD7" modified="2012-11-28" version="1">MRAAFRIARIAARAAPAPRAAAPRALPSPLPSSSVLATSSARAFSTTPITLKKATKKDAKKAGDNKKGGKKKAEVEVEETVMTDAQIDAIVKKANEKMNKSLDWAKSVLFEGVERGRGRVSPAVLDTVKVAIPDQGSQPLKAIASITVTKGGLLVEAWDSDTVKHVESALHKANLPGMSPQRDGDRIRLPVTRPDTSVRNEIVRSLGGTVEDAKNQMRQARSDGIKSVGGKNFRGADEIQSALERKSKELDEQLKTAKKELEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHI2</accession>
    <name>K1VHI2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cleavage/polyadenylation specificity factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHI2"/>
    <dbReference type="FunCoup" id="K1VHI2">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VHI2"/>
    <dbReference type="eggNOG" id="KOG2071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015606_2_0_1"/>
    <dbReference type="InParanoid" id="K1VHI2"/>
    <dbReference type="OMA" id="ARSDFAN"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="611" mass="66912" checksum="DED3143B76080B7D" modified="2012-11-28" version="1">MYGHYPPPQHQQPNHGGYYPPPDPFRAWYADRLSELTFNSRPIIQNLSIEAMKQRDQNNWQAMQAIVEEIEGAVLRAPPQGKLPLLYLIDSISKNVGAPYTDKLLPPIMPRLYLRAYREVDGVTKSKMEEMLKLWRTGGPYGAELYPAGVREEVERGIFGSALPAVGPPVPPAVSTPPQQLTQQSVQATLRAFLREKEEEMAQEFSMAKAKRVDVLVKIDQLLSSTQVSQNELVDIMEKIRAMQAGKEPGAAPVSRPPPAQPNFQPRAPYPPSQAGGFPQPTPTYPPFPTQPPASYRSPLGAGAVPTPPPAATPLAVPGNLNVADILKNLSGVLSQTHTPEPAPTATPKDSLQSYEDMILALDMKVDVFDLSKLSLPVSHLPVRCKQCGMRFQEGENNLQAHMDWHFRRNRKERETEGRGAHRRWLPRAGEWINESNEAGPSSPVKQEATLASANKLSAERIAALRRKWVRAPSDPNNAPPCPICKDQFKPEFSEDEEEWVFMNAVDVHGTIYHATCRAEKMSTVAAKRLLANEPRGGSASPGPAGEDIPSPGTKRKAEEESDAASEGKRAKVEDVKPDVSGDAAAEPAVQTPPEGGAVKTEPETEANGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI58</accession>
    <name>K1VI58_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI58"/>
    <dbReference type="STRING" id="1220162.K1VI58"/>
    <dbReference type="HOGENOM" id="CLU_063099_4_1_1"/>
    <dbReference type="InParanoid" id="K1VI58"/>
    <dbReference type="OMA" id="IARQCEH"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852179" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="10867" checksum="717AF6427E0D8152" modified="2012-11-28" version="1">MLYSAVISLLAAVAVVAQDGGATVATPNGLTTCQPTLLTWTGGQAPYYVSIIEGGNPNGKAFKTWPATEATSLTWKVAEVPAGQSITVQVKDGSGAVKYSAAARQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIM2</accession>
    <name>K1VIM2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIM2"/>
    <dbReference type="eggNOG" id="ENOG502S3SS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891946_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIM2"/>
    <dbReference type="OMA" id="VESHQIN"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="312" mass="35629" checksum="73DF94DD1193A7A9" modified="2012-11-28" version="1">MYTFGFNYGKYTTLIDYRWVAWFPLLDFFMAAGVQLFYAERAWKVTGRSNIFIGLAIMPFLLSFVGSVGICVKGMASRTYLDDTYVLFGFLWVVGMFLTDIVITGTALWGLYQSRSEWEQTDYIVRRLIRVACESQLPPTILALALLIDIIIQRDTWYAVFFELIQGYVYIIGMVYVLNQRQSLNRTLEQATVQRSSQFRLGSRNRFPAGPATIHVQTETYVESHQINPEFAEHKIQPKLRQISETEFEGTSSSGHEGEYELAESSAGYGTINQSLSNLHMAVQENASRKQRTVDMDSLRGDSLRGGFEKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ84</accession>
    <name>K1VJ84_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ84"/>
    <dbReference type="STRING" id="1220162.K1VJ84"/>
    <dbReference type="eggNOG" id="KOG3801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120076_2_0_1"/>
    <dbReference type="InParanoid" id="K1VJ84"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="129" mass="14316" checksum="8A5A5095C7AEDFA5" modified="2012-11-28" version="1">MSTKPTLAQVQALYNATRQASQRYASYNFRKYFLQRTDETFAPALALLGDKTTTPPDALKAAGAAAQAAQNGYGAPHHLPDLVNDNGVLKEDKLESWWKLAQSEFGPIERQGQISEMYKGTQRLVVENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKL3</accession>
    <name>K1VKL3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000363">
        <property type="protein sequence ID" value="EKC99756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKL3"/>
    <dbReference type="HOGENOM" id="CLU_090088_1_0_1"/>
    <dbReference type="InParanoid" id="K1VKL3"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30037" checksum="6783A6F9521D8691" modified="2012-11-28" version="1">MSDTSNVRDHHFWRFGDFILISADRVRFRISSRSLFMARWASSTPKLTLSKVFADAAECAGSSEKILEFTDQTIESAAVLDVFMRLAVCGEYFLSSSFGPSKDNLTDLEDCQRHMNVLNFLKKYDCPILIRLLEMSLYDLLPYDSVRRIPIFFMGAVLENRNICAAALEKMCKANFEQRTNTSPPRVCPADPGSISNDIWKRLPPKYARAWVVGWAMGEGAGGHLNDPGQHNLDQVIRCFKYATESYDSDDEAESDDSDGKSEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKU2</accession>
    <name>K1VKU2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKU2"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_3_3_1"/>
    <dbReference type="InParanoid" id="K1VKU2"/>
    <dbReference type="OMA" id="ATFTIHD"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="360"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="678" mass="77600" checksum="1E9D91198E3166A0" modified="2012-11-28" version="1">MAVTFSFPWAAWARPSRRMLYVLGTIMAVFLVLFNFAPHTLPPVIAPGRGGYADSSYQSPDKWMPPILSNSKSRPPPEWDANGNCLFLSPFDALTDEEKALADTIELDLVSPGNVRLKNHTSEVPADIKANPILRLLRDGEEKWNNMMNSQSKTLEEAVRKYEEKWQRPPPKGFDQWWLFAHSQNTLLIDEFDSIMESLLPYYGLPKETLAERTKEAEKIVETYTIIVKDGKAEIQWNDDYARDMWSSSRPRADDQVNIMEPFLHLLHDFRATFTIHDQPSIQLEAGPQKELVDAALAQRPVKFAHDVDHLERDWKKMCGEDSPLHRGEVETHGPGTFIHDHLPAMDPCTHPSIMEKHGMFLEVHNKDSHPQPHNTLYPIFALSKTALNGDILVTPFFRAGRHDVGYDPKWNDKKGKVYWRGRATGMEHNKGASSKWRHSQRERLHWLANSKSSEPMTIMEPKDASGAARMVNRPKNKLGQFYTDAKLVGGPWQCDGNDGTCDEMAAEIDFAPLEGKDKANEFKYILDVDGNAWSSRFPRLMLAFNVVIKSTVFPEWFSHILPEWYAYVPTKVDYSDLYSIMSFFRGSMDGKGGHDEVARRIALNGQCWAEKTLRYEDLQVYMFRLYLEYARLTSPDRDNGKMDFVLEDYHRDGSSNEKNAGDEVGKLEAIPGIDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKV5</accession>
    <name>K1VKV5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKV5"/>
    <dbReference type="STRING" id="1220162.K1VKV5"/>
    <dbReference type="HOGENOM" id="CLU_2122800_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKV5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="114" mass="11978" checksum="545FF5032DA6C26E" modified="2012-11-28" version="1">MVRYKVRQTREAVKVPCATEIAALLMCFSATGDIRATSEGASGCASAMRNLHKCMEKGGGGGKGRASSVSIAVMMGDGEPVFVKAVWRPLGSAATPCAREPANSQINYLLSKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKV8</accession>
    <name>K1VKV8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiopurine S-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKV8"/>
    <dbReference type="STRING" id="1220162.K1VKV8"/>
    <dbReference type="eggNOG" id="ENOG502QS1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_1_1_1"/>
    <dbReference type="InParanoid" id="K1VKV8"/>
    <dbReference type="OMA" id="RDFISVW"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27734" checksum="7D836452427FE50D" modified="2012-11-28" version="1">MSASAPPAAPTDPKRYIDGWEKKWVDNNIHWDQGKSHGALVKFLNDDTETAKAGIPKGGWAFVPGCGQPLVGTALPAEKRKARLRGPPSTANNQGYDVDLFARHGLDTIGLDVAPTGVVAANKWLESQPPRNARALVQQGDFFAYKPDELFDLIYDYTFLCALPPAMRKDWARRMAELSKDAPSTRLVTLMYPLNGDPNIGPPFRLTEEEYHELLGDEWEITWERAIPEDEKRKGPPGDEKLAVWKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKY5</accession>
    <name>K1VKY5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_04263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKY5"/>
    <dbReference type="FunCoup" id="K1VKY5">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKY5"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_2_1"/>
    <dbReference type="InParanoid" id="K1VKY5"/>
    <dbReference type="OMA" id="MGVMKPD"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD01421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="169" mass="16904" checksum="26A20CB444566163" modified="2012-11-28" version="1">MSTAADLCPAYAPFFGAMGATAAIVFTSMGAAYGTAKSGVGVSAMAVLRPDLMMQGVIPVVMAGILAIYGLVVSVLIAGGLKSPMPLFTGFVQLGAGLSVGLAGLAAGFAIGVVGDAGVRGFAQQPRLFVGMVLILIFAEVLGLYGLIVALILNTGSVPTTYECPAPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLQ6</accession>
    <name>K1VLQ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLQ6"/>
    <dbReference type="STRING" id="1220162.K1VLQ6"/>
    <dbReference type="eggNOG" id="ENOG502SNFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799307_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLQ6"/>
    <dbReference type="OMA" id="IPYCERS"/>
    <dbReference type="OrthoDB" id="2564987at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852249" evidence="2">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="320" mass="33630" checksum="9F035DF427235ECA" modified="2012-11-28" version="1">MYALSMLFTTLASLAAVSAGGNVLFSQDNMRATVYYDVASGDQCGQQNGGPFPADWAVTSGINDGIPMCQNLKKGSLKQINSNQIVAMDHNMMVAHPDWCGKEVKVYRPDGSEVTIDDGPLVLYDGCAACMTQGIIDLSAKAFIAASPDRKCGNNPEGLRVEILDNSPWGGDSGSAPEPPKSSEAPAPSSTQAPAPTSTEAPAPSSSTAGVPEPSAVSSIVKSAELQGHNFKAKPTTASVKSEQVSSTISIPDEIPTSVQPDQVAPTSGSEAQCQYGKWSCDGKDLQVCNYITNDLLDWECVSTCENYCEVKDNGMVTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM32</accession>
    <name>K1VM32_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM32"/>
    <dbReference type="FunCoup" id="K1VM32">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VM32"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2098549_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM32"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090161">
        <property type="term" value="P:Golgi ribbon formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042887">
        <property type="entry name" value="VAMP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46897">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46897:SF1">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="124" mass="13950" checksum="FDC201972956CBB9" modified="2012-11-28" version="1">MHQNITKVAERGERLDNLQDKTAQGFRRGANRVRKQMWWKDMKMRVIIAIGIAVLIVVIVVPIVKAGFTDNIFGNYKGDTDAKAELAIGESPGQLEMLEARKNYQGPGGCRWRRYVQDEGASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMB2</accession>
    <name>K1VMB2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMB2"/>
    <dbReference type="STRING" id="1220162.K1VMB2"/>
    <dbReference type="eggNOG" id="ENOG502S71A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="InParanoid" id="K1VMB2"/>
    <dbReference type="OMA" id="DITTQHE"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853920" description="NAD(P)-binding domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34197" checksum="5C2C414564361EBF" modified="2012-11-28" version="1">MKVLVLGASGFIGLPTALAFSRAGHIVYGTTRDAKSARKLEIHEIIPVITPPTPGHGAAHWSKIAQDCDVIVDTIRTSDGDAPEGTLHAAEALSSSSPGTRKTYIYIGTLADLQAKGAGIEGWVSETTAPTGQEAWRAQLENQVLSSNAVNGIVIRAGILYGRSGSTLEPYLFAPAYDASKNGGAFDTVGFPETRVLMVHQDDLAELVVRAAERAPALKGVALAAANPQSERWTDVLDAVIRVSGASEYRLRAPGEISAEAAWASTTQLRPTLAHALTGWTPRKLGLVDGMDAYWAAFKAHYVGKKMIPAWDLPGVVPPRASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN51</accession>
    <name>K1VN51_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_00105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN51"/>
    <dbReference type="STRING" id="1220162.K1VN51"/>
    <dbReference type="PeroxiBase" id="11639">
        <property type="entry name" value="TasAPx-CcP2"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035270_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN51"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF53">
        <property type="entry name" value="HEME PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="9">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD05615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="564" mass="60507" checksum="6E82915EED88A0B7" modified="2012-11-28" version="1">MLFNVLPCQAGGTNRDNAAEWLRASFHDAADHNAAAGIGGIDGSFKYEAGYNGNRGLQMRSVVSQYSGFQGEGVSFADIVVLGALDAVRSCGGPIIPFYWGRTDVSSGGPTDALPEAEDSTESHVQRFARMGFSPSDMVAMVACGHTLGGVHSANNPALTSQGYHHFDDTFAHFDNHVAVAHFNHGSPNPMGQQWDAANPGSSSDTRVFSVDGNVTIGRMAQSDAAFHHECVDAFSKMWNDAVPSSVTLKGPMQPLKVATSFRSYMRNGVISFNLGNARLYDMEGQWSSFEVGYYNRDGSVGTDNSILQVGELVTFDVGVPLETKAFNFLRPSIDPATGLGGLFVNVQMKDGSAAPIEADSFQPFQDTVLVDYGNLYTCKYKGDASKVGLNMTAVVLAPYDASDKVEFFLRTSSGDQLVRAAYRGPRDDYYNLYNLFIEDIDAIGLTDFTVQLTRSDGTVIRDTHGDGTLYSTSVGTCGAGEIFPSNPVPSGTIARRRQLNPIREAPEPCPRGWLMCNDRCTNTASDLEHCGGCAGFGGIDCTTVSDGTIACIQGKCVVTDESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPA6</accession>
    <name>K1VPA6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPA6"/>
    <dbReference type="eggNOG" id="ENOG502TKPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973820_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPA6"/>
    <dbReference type="OMA" id="DEAVRNW"/>
    <dbReference type="OrthoDB" id="2594273at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="31675" checksum="4BE5C07661122C74" modified="2012-11-28" version="1">MDDIFDSTFPQGTAAAAPTHEHHTAAGDEHAIINEGSNLPDAAAHEQPLRGKAATQGLTMEEKKERQKLQNRRAAERSRNKKREELTALEMTVNNIQDENNRLRARLSTLLASKSAEQPPSSGDQELITGTPVDYSHLGKLQAELASAKSTLMDREMELSRIQGGGDEDIEKLRRDVAQQNTALQNTQAEVKTLHALIKQLRSERDNLARQKDVLTREIEARRLLRDSSGETPSLSTNARAAGVERALLELRGLIDGVIRSWDQASLTRYRAADVAGRTFAQQTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ92</accession>
    <name>K1VQ92_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ92"/>
    <dbReference type="STRING" id="1220162.K1VQ92"/>
    <dbReference type="eggNOG" id="KOG3101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056472_0_1_1"/>
    <dbReference type="InParanoid" id="K1VQ92"/>
    <dbReference type="OMA" id="PSDCPWG"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="31707" checksum="558C5DB963B4D89A" modified="2012-11-28" version="1">MSSLKSTAENRVANGTLTKYTVPSKALGLDSPVNVFIPPGFGPDKPAPVLFYLAGLTCTEDTGAQKGGFFNTAAKEGIALVFPDTSPRGAGVEGEDDDWQLGTGAGFYIDATNEKWKHYNMYSFITKELPEVLAPLGLDFKRWSITGHSMGGHGALTIYLKDPTRFKSCSAFAPICNPAVVPWGKGAFGAYLNTRTRSNPPAEWLEHDASHLLQASQAPKGSLHMLVDVGTADKFLKDGQLEPQALERAAKDRGAPEELDLRMQDGYDHSYYFISTFSPEHVQFHAKYLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQP4</accession>
    <name>K1VQP4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQP4"/>
    <dbReference type="FunCoup" id="K1VQP4">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQP4"/>
    <dbReference type="eggNOG" id="ENOG502RYJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="InParanoid" id="K1VQP4"/>
    <dbReference type="OMA" id="GLCFICV"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="5">
        <location>
            <begin position="211"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="38493" checksum="2F9D73FFB23784AB" modified="2012-11-28" version="1">MLPSLRTLSSVSRMTQTSAAKQPRALVFGLGAIGGIYAAILKRSNACDVSIVARSTYDGVKKHGLRFNSEKHGNEVAQFGDNEAAASGSFDYVLCANKALLDAKPSLAELISPVIGPETAIVLLQNGVGNEVPLHAAFPKNTILSAVVWTGGRVVPTTDGSVEVAQFAREGLTIGVDHAEGADPEQEKAQLDRFVDILHKGGSTDTVTTDDIQSARWIKVIWNCAWNSLTAVTRVRTNHIFQSSEGAADLSLELMREVTAVAKAKGLNIPDGTPEKLLNDVQVVPGPGLPSSMMMDNEAGRPMEVEVILGTPVREGKRLGVPVPILTTLSTGATPTGDPLNLCMMMRLTWTTTKRKATEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR75</accession>
    <name>K1VR75_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_06417</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR75"/>
    <dbReference type="STRING" id="1220162.K1VR75"/>
    <dbReference type="eggNOG" id="KOG0470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012922_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR75"/>
    <dbReference type="OMA" id="IPDYWIK"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycoside hydrolase family 13 N-terminal" evidence="13">
        <location>
            <begin position="54"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="11">
        <location>
            <begin position="292"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase/branching enzyme C-terminal all beta" evidence="12">
        <location>
            <begin position="584"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="969" mass="109690" checksum="CC4204D3A44E8381" modified="2012-11-28" version="1">MSQQTSKAPAMSKDGRSLPYSGALRDRYSAYQKALQFIDTHEGGLDRFTQGHKKMGFQIDDKGGVTYREWAAGAVAARLIGDFNNWSHTANPMTKNEFGVWECYVPPTANGKCAIPHDSMVKISMTTADGESIDRLPAWITRVTQDLDVSPVYDARFWNPPAEDRYEFKNGHSTNSIEGLKIYEAHVGISSPEKRVTTYKEFERDVLPRIKDLGYNTIQIVWLPGHQLFRGLVALRFVEWFFAVLTIGTPEDLKSLIDTAHGMGITVLLDVVHSHACKNVLDGLNMFDGTDHLYFHEGSRGRHDLWDSRLFNYGHPEVQRFLLSNLRFWMDEYNFDGFRFDGVTSMMYKHHGDYHEYFGDSVDQEAMVYLMLANKMIHDLYPNAITIAEDVSGMPTLCRPVDEGGVGFDYRLSMAIPDMWIKILKEKQDEEWDMGNIVHTLTNRRHLERSVSRCVRDNVGVKLTADDYMSDLSPLTPIIDRGISLHKMIRFLVHSLGGEAYLNFEGNEFGHPEWMDFPREGNGNSFDHARRQFNLVDDHLLRYKYLNAFDAEMNNLESKYKWLSAPQVSPIVGGKGMLTLKAFVSLKHEGDKVIVFERAGLLFIFNCELWEDDYRVGVDVPGKYHVVLNSDEKRFGGHDRIDNSGEYFTTPMEWNGRKNWLQVLNVKVSAFAERACSIDVRATVCFTSMSSITSSTMPFLETLNGLIEPLLFIGLSLSYVPSTISQVFRERRLVSWDQFQFLWFGNFWRTVGPMVRDGAEARVVPLLQGRVRLGTAVPPDGDSRGLPPGVGGTVIEVGPGSGMWVSIYGDQYATLSDTVDKSIPGKRTRVEKVFGIEPNATHHAALQSRISEAGLDGRYTIVPVGIEDIGSTGLIPKGSVDAIVTVLCLCSIPEPEKNIRELYEYLKPGGRWFVYEHVKCYASQGNFMRWYQSKSLRAAGPWKEIDLAMPTDAPWWSTTPHSYGILTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS71</accession>
    <name>K1VS71_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="8" type="ORF">A1Q2_02258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS71"/>
    <dbReference type="STRING" id="1220162.K1VS71"/>
    <dbReference type="eggNOG" id="KOG3846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_1"/>
    <dbReference type="InParanoid" id="K1VS71"/>
    <dbReference type="OMA" id="SHVAYRS"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="7">
        <location>
            <begin position="218"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="492" mass="54772" checksum="FFF8184BF8DB1C05" modified="2012-11-28" version="1">MAPPNKDQLAQMDKEDPLNWTRSEFEIPDAKACGGEVGEYYSSAGKVSGLHGASSGYRPEPGGTVTSSSVARAQLTSDGEAVYFCGNSLGLLSKRGRELVMQELDTWSTSAVTGHFKHKYDRPWKHLDAPITPIMAELVGAKESEVSHSGTLTGNLHNLFTTFYRPTQKRWKIVIERGSFPTDWYAAHSHPNLHSDILSKEQIDNAIIALEPRKGEDTFREEDILKVIEENGDEIALVWLPIVQYYTGQYFNVEPLCKKTHEVGATFGLDMAHGVGNVKIELDKWGVDFAVWCTYKYLNAGPGAIGGFFVRDGLDDGGRRMAGWWGNDPSVRFEMKEEFQATPGAKGYQHSCTSALGTIPLLGTLEIIKKAGFDNMRKKADKLTGTLQELLEASPFYVKEAPKEGDNKVGFRILTPEAPWRGTQLSIEILPKVKGTMPRVFDRMLKQGLVGDERFPYVIRLSPCVLYNTFSEVGRAVEILNKALEDEQKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSD7</accession>
    <name>K1VSD7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSD7"/>
    <dbReference type="HOGENOM" id="CLU_1031295_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSD7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="270" mass="28846" checksum="A12C02C1FDB084DC" modified="2012-11-28" version="1">MSTVTRNAGKHICHEPFSARGLRSRSSAWGLCLDGVCARSSIRTSAQAPVGPNRLAVSAGFSLPVAMYKRIPIFDEHPHKLMPQYTELLAKFRRRRLRTSSSTTSISSAASASSSSTVTSSTMSATKPSIPIIPLNAPSYVPKPAAESIDLGVVTVPESPTSTPPHTPFHKQVQSALANPPKVSGAPSPMLCWVVPAAPMSPPESEPSSPSHVSTVPEPAVAPLRRQPLMLPPIPARNPVNELESEVRELRKQLEELKKVNTKIAALHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSI4</accession>
    <name>K1VSI4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSI4"/>
    <dbReference type="STRING" id="1220162.K1VSI4"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="InParanoid" id="K1VSI4"/>
    <dbReference type="OMA" id="ESKHINH"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="57374" checksum="09E08BEFF1014052" modified="2012-11-28" version="1">MTVTPVAKLPARTHAIKLAGELTKQLPEAERQGEANFNYLTGAHDVHDASVLITFTPGANNVQHTLFIPPADPLETMWSVAPPTLDDARNRFDAGEYKATTDIASALSQLPSDVTIHTLPVTHEFPPLPSAVNEVLQKAKHSSEHLRTALHIARLTKTEEEIDLIRKANAITSGAHEVLMRELGRFAARRAKGAPSSKERTGHEALTEWEVESEQDAEALFVATCRRMGAEQAYLPICASGHHASTLHYVLFPSTATPRVPGDTSFTPRRMARGCCGDIPDHDHASSTSALHAGAFEPQILLIDAGADWQGYASDVTRTIPVGNGGKYTDRAGEIYELVLRMQKETEDMVRVGAHWDTLHLRAHEILIDGFLKLGIMKGDAETILQTGVSAAFMPHGLGHSLGLDVHDSLQYLRTVHLDLPERTKQTPAKLYTYLRLRQKLQDKMVLTVEPGCYFAPQMLDEHGVWDNQYIDHEVLKKYLPVGGVRIEDVVVVRDGQKCENLTTVGRDRTWVEARCSGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSK2</accession>
    <name>K1VSK2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSK2"/>
    <dbReference type="HOGENOM" id="CLU_2251929_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSK2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="104" mass="11079" checksum="DB05B2AD5790A5AE" modified="2012-11-28" version="1">MFALRRSVAPVSRSVRAFSVSPMSLKGSKDSKEAAFAAAADVEEYERSFGEGASENKANDTAQNIANKIEDAAKKAAAEADAQVQSYQDAELGLPQSNPLKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSM0</accession>
    <name>K1VSM0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSM0"/>
    <dbReference type="FunCoup" id="K1VSM0">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSM0"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068297_2_0_1"/>
    <dbReference type="InParanoid" id="K1VSM0"/>
    <dbReference type="OMA" id="MIFGFDP"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="22852" checksum="BEC9025328FA597F" modified="2012-11-28" version="1">MSLARASLGLRVRTLAPSAAVARRFNSTSASTSTATDEVPPNYTSPRDLPMTWSDYLAMRKRRRQWSSITSIPTSLGGLIGGAMYFASKDVDPTQLIFGFDPYMVYGGATFACMAFGWLLGPTVGNALFGVTHPKLSKGNPSPLEVMDREFFNRIKSRRVDPSRQSMNNPSPDFYGEKITSIPAYRQWLKDQKAYAAKVSHGVPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSV6</accession>
    <name>K1VSV6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSV6"/>
    <dbReference type="STRING" id="1220162.K1VSV6"/>
    <dbReference type="eggNOG" id="ENOG502S1N4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033184_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSV6"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="601" mass="68257" checksum="E7AC0C5545EC3AA0" modified="2012-11-28" version="1">MHGEHRRSPTLDMDQDETPLLFKDKDFEPTPPSAGWWRSKPRFGRRLVPLVLVIAVLVFGGLFMLRGVPEHLRSAASREDDLDLVVRLRLLLQRMEEHYASNPDHDTTILTLPAIRRLLDCVEKETCGPGERDVVIFACQRFAGAEKGRVSGENIWAASTIRSFRAMNNTMLYGQGSMDSLLMYQHVPELVRLVFWESSSLDACIARNGTLDAYEDEDYRRAADNWQGGRGREKGCMVRDDFPDGIPYYKSLVFHFWGDARTPLGHEFTLAPWDFSALHDDTNRYLGFSIEDHCMTNKYYPPEERKHQALILGKLAEYFYPGPHNWIAHETLEEAVQDLPKENGEDFKLIATAKQDGVNGSTAVLPEHITNLGFQKQHEWTDLLARSKVMVSVCSAAFTPLSPIRPSPLLLPRAWPLKRLPPRKSANVQIGLGWPAYSPSPFDALCVGVPFINPIQYVNLEHPDDRKGWRTQNDALLALDPPYVYHVHKKNATELGHALKSAIENPIPRFIPQQGGMGGRSNSRPAPRPAWTFADPTAENMKFENVLERHRVLMTRNPLVVAEAQWEKLYGSNPAMEYLLLPGANSTAYERIHWQYRKTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSX5</accession>
    <name>K1VSX5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000362">
        <property type="protein sequence ID" value="EKC99767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSX5"/>
    <dbReference type="FunCoup" id="K1VSX5">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSX5"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSX5"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC99767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17974" checksum="E2430B009BF9E853" modified="2012-11-28" version="1">MVKLIVEIAMELENLASVKPAPDYEYFFNVTCTSCREEHPKVVSFNQQDEHELSGSRGSANFVWRCGNCKSCSFTPAGKDKSTAPLPYTSDSGALQPLVALDCRGLEVTKFHFRGKWVAETEGGKEMECDFDEGEDRWDDYDEDGGVPVSVSEMRSEVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT63</accession>
    <name>K1VT63_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT63"/>
    <dbReference type="STRING" id="1220162.K1VT63"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568816_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT63"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="9">
        <location>
            <begin position="385"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="480" mass="51453" checksum="D57966B4C062061D" modified="2012-11-28" version="1">MSGLLPSLGRALPSASSSRAAAFSTSALVAAAPKMGAKSFAKKKSPSKRQGPSPRVKVHRLKLTSNLVRPAPDMSDLVQLFPESIIAENTAKLSVIPRKTFDVIQTFGLPAKVDKDLTLGAPATVIRQATLDIVKALENGKDGDSQSACDGVSFVHLSCELTAVHVNGLNWEIIKCLTLKYGCYTYVELIRARWGPVAHAAFLFFGLATNVIVCTMLVLGGSATVTSLTGVNTVAACFIIPLVVAVYVTFGGMRATLIADYTHTVALYAILIAFALVVFEEGQSDRKTQVRVSSWFVVRTDISATLLKSTRVTFVVPSVPFGIRSGVRALRSPSSGTDHDPNSIALCLHLPAMTLTSRPAKRLRSSTRLSKAHTATRSDPPADAIKDAATAEIARVQLWQWNHYGKSTDSGKKINVQNLKPIFEEEAAKVAKLPGISAKHVQIAKDYMLSQVAANYPSEFLTSDLQCHLDGGSVPRKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU69</accession>
    <name>K1VU69_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU69"/>
    <dbReference type="FunCoup" id="K1VU69">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU69"/>
    <dbReference type="eggNOG" id="KOG1475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_4_0_1"/>
    <dbReference type="InParanoid" id="K1VU69"/>
    <dbReference type="OMA" id="ALYGTWR"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="4">
        <location>
            <begin position="266"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="364" mass="39782" checksum="FBE6AAB377729FA8" modified="2012-11-28" version="1">MAARPTVSVFSASGEASGSVPLPAVFTAPIRIDVVQAVHKSIAKNRRQAYAVAENAGHQTSAESWGTGRAVARIPRVGGGGTQRSGQAAFGNMCRGGRMFAPTKTWRKWHVKVNQNQRRYAVASALAASALPSLVLARGHRIEKIQEVPLVISSAAEKTEKTKAAVELLKSLAAYPDVAKVSNSRKIRAGKGKMRNRRYRQRRGPLVVYGKDEGIVRAFRNVPGVETSPVDALNLLQLAPGGHVGRFVIWTEDAFKALDKIYENKSGFTLPEAKISNTDVTRIINSDEIQSVVRPAGQPTQKRPFTQKKNPLRNKAVLFRLNPYAKTLRRQELLRQERKAAGKTKKTAKTGRAGKEFANTLFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUI7</accession>
    <name>K1VUI7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUI7"/>
    <dbReference type="HOGENOM" id="CLU_398597_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUI7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="400"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="656" mass="73043" checksum="B408A6FEB830D8A9" modified="2012-11-28" version="1">MITSNGGTLVTSPLIAAYVLVDIPFERTAPEQRKFYIHQRRLDSSLSNWDRWSRDWTWTLDELMGLAADKRLVCAPGNTDNDDQSDDENKIVEDDDNDDDEVSDIAAVVEDGEILPISSTRSSVASKLVVQRCWLKECIKAGRVLDHDCGWYVECVEGWQYPEWDKPRPEENTIATSEDQSRWTWGVRVDEYGFGFGWRKEPVTQPAPASPPAPSPPRQRAGTPPWCVPPMRVNASSRSVSTPSKPTSRDPKTSPWRFRELDGYRVPWSERDSAFSRARREKPSDDMRPDLRTGPDFGRPRSPGRLFRSAAWDAHRQPLSVSAFHMGRAPDCHRADRDYSRGGGVSGGRKQYKVKGKRVTSSSKPSASSTLKKTAAAKSSVSQIFCAAEPLVFMDFSGARDGLVARIKRHGGRMGESKEADYVILRTQPGQTRNSTFLSAIRGERHPRKPGSSVVAKEWIDKCISAGKLLDCGPYLVTAGPELPRASAVPMTPMIATSPPPEARKRIRPATPEPHYPKDSTPHPATPPGGLPPTPPSAVENTLESTLAYDDGFINLDYDDGEEMLIDLDVHLNIPSHYDWSKTPQIELPPTVLSTHIDAVRILISELTIWDGEGTKAECLNRIKKKAEELYGTYRSVINERVPGLDYSSGTKRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUQ7</accession>
    <name>K1VUQ7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_05173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUQ7"/>
    <dbReference type="FunCoup" id="K1VUQ7">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUQ7"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1344094_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUQ7"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="177" mass="19529" checksum="36550584FD2A1614" modified="2012-11-28" version="1">MTQPCRAQLNLNLDPSSIHPASPAMVLVLVIGDLHIPTLTHDLPAKFKKLLVPGKIGQILCTGNVCDKETYDYLRTIAPEVHIVRGEFDESLRIGVAHGQQVVPAGDGEMLAALARQMDVDVLVTGGTHRFEAFEFDGRFFGPVIVTYVYQLVDGEVDKVEYRKPDRSQDAQQSSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUT2</accession>
    <name>K1VUT2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUT2"/>
    <dbReference type="HOGENOM" id="CLU_611373_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUT2"/>
    <dbReference type="OrthoDB" id="2590973at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="448" mass="48469" checksum="9A4199EC0FCC8D17" modified="2012-11-28" version="1">MLDAQRVSCTQVEHVQPYASREDASEPSCRAKPAPASLDLTRPLRRGSTSSWRMRAGSGPRGFKEEAQVSRVVSLPRPVPGWHSGGWRGTRTLTPSHYPLPTSTVRSACARASPFSPHQAPVSYPTSSDPTLRTFLPGRPLPLLRRRQYNTNKASALSSPLPSSPSTTFLISRTVLFFSLSVPSTSPPAANMPSLKTLMFMRIASLLTAGAFTVACVGLAGKSLKDLHDNRVFLPMGIQGGIDAKDVLGAMGAMLGAAGLGVICPLGVLYPTLPKTKRAGLSKPPGPPRGAGVQSPRAHVTRCSEIGHFISEFIWWKEERGGFLPFRFRFINEIMLGISCIFLLAASIAAAIICGTKSAKIWLNPPMPQAVVDGMLKATGKSVRYRDQKAFPAMIMGWLAFFFLVISLILTIMAGLHYRRVAAERRSSNGSANHHEKFSEAREDAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV19</accession>
    <name>K1VV19_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV19"/>
    <dbReference type="STRING" id="1220162.K1VV19"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_305922_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV19"/>
    <dbReference type="OMA" id="AFETHGH"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase regulator activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0440">LIM domain</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="785"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="937"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="632"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="128"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
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        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="994" mass="106533" checksum="3344292ADD477235" modified="2012-11-28" version="1">MYSTQTPSYPTGVNNPPHPHQQYYQQSMPGPSTYPGAAHAQPQHPQHPQQQAYAQPQQQQQWYGQQQHQQPQQHPQAPPPQQPPQPYQQPPPQSAPQPGYHQQSFGQQPQPPQQPYAQHSFGQQAYPQQTYGSYGQLSQQSHHSQPSPHSSYHSHPSPHQSYGQHPTPQQYAPQQQYPQQSLPQTHRGAQQAYQQSYAAQPYLEQQTPPRPLARSDTVAIPSPQRKTDYQAPAFKTFQERKREREAALRAAATASAASTPTPSTPTPPPAAQTATSSPAQPNGQSPAPSQPNLPPHVLAMMGAPGSGRPVPLPRANGSPAPPQRNQPVPGQQSQPPQPPQRSPSPQPPLRSHSPQPPQRSAPPQPPQSPQRSASPQPPPRSVSPQPPQRNPSPSPAHPSLANFKQPPASTSKFAPPPAPPSWMTGGSDSAPKTEGSDSRSSSPTREPLPRASEVPKSPQPTRMGLQNGSGGRALPTPAGAPSDAPTPSAYQLMRSGGFPSNIPRNRAVEELLQRSDTVASVKSLDRGNFGPGKRVLPSPPVGVSASQSLDRGAMSAAAGIRRSNGRKSPSSPIAEEGPDDLAQQMAGMSVGSGSRSPTSNGSNSPRTPMTPVGFPQAPTIVTPDIPVISVGEATPKVPQINIGSPPRSRSPAPSVPQINIGSPPKSPRSVPAVPTISVGSPPKPPPRSVPSINVGAPQVPSINVGSPPKAPSIRVASPVNDDPQPPSIVVPPPGISIGSAPSSPRAERPASPSGFEFSGQPTIAVESSDTRASAGPTRVHASSAIVCAGCNEAIIGRIVSAMGKRFHPQCFQCGVCGEHLEHVSAYEHDGQPYCHLDYHERFAPKCHHCRTPIVDPRFITLNDEELGQRFYHELHFFCSECGDPFLDPSKSSAPGTQRSEAARRGIEEEDEVDETNDFVIHKGHPYCERCHLKLHKPKCKACRQPIPDIAVGALGGKWHRECFVCEQCRSPFANNLFFPLENKAYCVECFEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVX3</accession>
    <name>K1VVX3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVX3"/>
    <dbReference type="STRING" id="1220162.K1VVX3"/>
    <dbReference type="eggNOG" id="ENOG502SBH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1972022_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVX3"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="127" mass="13506" checksum="F1685C5667B3A871" modified="2012-11-28" version="1">MSHHPTIEPLHAPGRAAVVQRQRNVSGPVNREFCKGVCNSQPANDVIPGQTVDPAVPGAAMGQKALLAKKMAQANSKPTVSPTDQHDSPTTRKLKNVKERHFAPGAKGKTPAMQRMAGLMDENSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWY9</accession>
    <name>K1VWY9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD03987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWY9"/>
    <dbReference type="FunCoup" id="K1VWY9">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWY9"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="InParanoid" id="K1VWY9"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="329"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="38537" checksum="691B96A9547CF189" modified="2012-11-28" version="1">MADASSSSSSSDITLTIKGPSELKLSITISPNKSVADLKDAIAAKCDVEKARQRLIYSGKVLKDDDKIEAYKIQNGHTIHMVKGAAKPAEATPTPQRLPQMGTGLSAGNMADTIENYHHGLAGFNPFQGMGIGNLQDPNAMTGLMNNPEFLRQMSDLMSRPEVVDQLAAMGPQMRQVMQSPMFRQMMSNPETLRMMQSAMGENGMGGMGGMGGLGGLGGLGGFGGAGAGAGAGGAGGNTANDPFPNLFAPGAGAAAGNTAGAAAGNTAGNAAGATGNTNAANPSSPGAGAPPNPFAALLGGAGGAGMNPFMMDPSLLFGGAGAGGAAAPRDDRPPEEIYATQLGQLNAMGLWDAQKNIRALRSTGGNVEAAIELIFSGSLDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWZ6</accession>
    <name>K1VWZ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWZ6"/>
    <dbReference type="FunCoup" id="K1VWZ6">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWZ6"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_1"/>
    <dbReference type="InParanoid" id="K1VWZ6"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="579" mass="60996" checksum="93EB7C3F80F46BA3" modified="2012-11-28" version="1">MLARSRAALPRPARLLNSQPAARRYLGSKDVIFGNDARQGMLKGVDTLAKAVQATLGPKGRTVIIGQSFGGPKITKDGVSVAKAITLKDPVENLGARLVQDVASKTNDTAGDGTTTATVLARAIYSEGVKNVAAGCNPMDLRRGAQKAVDKVLSVLEANKRDITTSEEIAQVATISANGDKHVGNIIAQAMEKVGKEGVITVKEGRTIEDEIEITEGMRFDRGFISPYMITDAKNQRAELDHPLVLLSEKKISALQDIIPSLEIAAQARRPLLIIAEDVDGEALAAIILNKLRGQLQVCAVKAPGFGDNRKSILGDIAILTGGTVFTDELDVKLDKATPDQLGSTGSATVTKDDTILLNGEGDKSNITGRCEQIRGVIADPTTSDYDRSKLQERLAKLGGGVAVIKVGGHSEVEVGEKKDRYDDALNATRAAVAEGIVPGGGTALLKASAQLDSIEVDNFDQKLGVSIIRNAIRRPVRTIVDNAGEEGSVVVGRLLSDEFVSADKFNWGYDAATSQYRDMIKAGILDPLKVVRTALSDASGVASLLTTSEACVVDAEDKSAPAMPGMGGMGGMGMPGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXB9</accession>
    <name>K1VXB9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dolichol-phosphate mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXB9"/>
    <dbReference type="FunCoup" id="K1VXB9">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601564_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXB9"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50155" checksum="5040C3859B4EE15E" modified="2012-11-28" version="1">MTISKPPSPTRPTRTPSRTQRYLAFQAHLHRHLRALGLNYHLHPPSMSVPATTFLNTLPVAKSLVIAVLELHFPELGAFHTRSEEFVDELLVRIVSAIREQVGPHTPRSAVEHLLERRDREEDIDLLGHIADPHCEWFGELSTFPITKERSHPYFTSGDLNSRRSVVFIGGLFNGMGDVPYLGMLSDALAQAGWKLVQLHWTSAYTGFATSSLDTDVSELASLVTHLRAAGDTTVVIMGHSTGSQDVMHYLLNEPIPVDGGIMQAPASDREHFGFADDAMSKAWAEKLPLATEFVKGGRGMVTLDAGGMKITAYRLHSLMSKDGDDDYFSGDLPVEPTEGFKHPLSQTFGKLEAPVLVLFSEKDEYVHVEDVPTMLRKWRDTANGKLETVIVRGASHAVETQGKEQLCGAVVAWLTEHWPKTQDSIIPQDNPNCPPHVPSVAPQDPSKPAPPIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VY38</accession>
    <name>K1VY38_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VY38"/>
    <dbReference type="HOGENOM" id="CLU_1361279_0_0_1"/>
    <dbReference type="InParanoid" id="K1VY38"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="201" mass="21672" checksum="641FE43844B981DB" modified="2012-11-28" version="1">MTSPDNGSQQPADTSSRPPLPTNSPRFAQGADWIEAYRRGRPLTWTDAWTVVKIKLATSWSNALRARKTLGLCLGGIHLFLRCREKDVEKTRPPPSRLTSSALILLGTVGGMAAHEWVTVFGDLQHWQIDGSVWKVIATRLCTWSPFSVTDHASSECLPSASAPTPASRLTRSRSPTGASRIAPDSSSSPGRAGARASHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYG4</accession>
    <name>K1VYG4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000221">
        <property type="protein sequence ID" value="EKD04582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYG4"/>
    <dbReference type="STRING" id="1220162.K1VYG4"/>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1134238_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYG4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="245" mass="25621" checksum="F0D56E8A5ED70116" modified="2012-11-28" version="1">MFPTVARSPPQNLGPLLKISVPSSKSRSPPQNLGPPLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPSSKSRSPPQNLGPLLKISVPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYU9</accession>
    <name>K1VYU9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYU9"/>
    <dbReference type="STRING" id="1220162.K1VYU9"/>
    <dbReference type="eggNOG" id="KOG4653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291057_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYU9"/>
    <dbReference type="OMA" id="KWGVEPL"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="694"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114034" checksum="8A0B9DEFC13E4E7C" modified="2012-11-28" version="1">MSEPDAVNLKTLLSSAKALLKPPQPLPSSPPALLERLRSSSELLPSWRSKPGWGEDDELDEIGDDDDSDKDKRKARRDALVQLVGKRSLDIVVGMQEWLEKEFWPLEARGGLDAKEYTPRPTRREATAGSQLELELALHPTNDHHHDAHQRALDTDRAGEHDAGMDADGTSTDAGKTRPPKAWIRRYPAYVESALSALMSGQLQRPGGVRGIIENVLGEAGNMVGPEAVDAQKLDQIVGLLARPPRGVPEEQYIPALMERLMELVAPESAAHPIVFTHAAAYIVYRLWYTNPIAKEWLDHHLHDPFLNPGPGDGVLVPPNQVARNVQALGQLMLHAPPNTDFVDFIMRPILPPIFALYDALSPSGTSIEKVKTSGLLEDVSTLLTSWGKLASEADGVAGLWSIVTGGRGWPASEDGTQLAWRPEGDSAALVRGYPAELEAGMDVDEPIRTAGEDLGEDALLNQLNLAPNPARFAQFLKRLDRKDLSSAILLKVLNAWRVRYAAGTDPLESLLYLKLTLEMIETLGPDKIMADAGNVLSFVEAVLGDEAKAAKQTQASATEEKKPKGPLIQEIDEGDGDAKMDGDEEELPELTEEGVAQLGLVETSISLLIAALEKDENINHATARILHPINDHLEVLSESSPSSSVRRLAREALLLLLLRRSQALSVGDSSNTKDAPADDSGRKVEASGTRATYQRALTLLSDPVVPVRAHGLQLLADLTKSPDYDPALTPGIMDAFMGAIQDSDSYIYLHAVTGLVEMCNNLGAPIFRSLVNAYCPGGELSGDRLDKALRVGEVLGMVIERSGKAFAANADTIVPRLMRMYPDASLPTVLRSSALSLLSTAVESSHLAMLPWMDELVSGCLDLIQLESVTGEKSAPEPEEPEMKTTTLREKLNPKIQLVDDEEVEEEKPKDEKPRIVDAEPTKANDSKHPALRRAAVYLLGLLVAALIEAAMEEPAPETEFKMRLPGQTDISADIRASGQKGQQQQQVDAGAINPRTIDRAVNILRYVASVDDDDVVRGQSAEVVALLERLKMVQVTKGIASGSRPLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYW1</accession>
    <name>K1VYW1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_00957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYW1"/>
    <dbReference type="FunCoup" id="K1VYW1">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYW1"/>
    <dbReference type="eggNOG" id="ENOG502RSAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_1_2_1"/>
    <dbReference type="InParanoid" id="K1VYW1"/>
    <dbReference type="OMA" id="SERVQCR"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="801" mass="88272" checksum="A6DD775E04E92DAF" modified="2012-11-28" version="1">MPIAVQHAYVLSDASALSSYQQQHHTYPYHASSSSPHPHYYQPTPLAHPHHPRVPIPMPASNQSGSESPQASKRKRSRAGCYTCRRRKKACDNVRPVCGSCTRLGIPCVFPKLYRNAKGELVPSPQPNGRTKKLPREDASLSPVQSTTSAGGSQHHIPWETPGASSSSAPNAPVNWTQPPPSVGQRKSDGSIDGNEADLTDSALDAFLANLGDIESGQSWAWPLFGDALELDLGPSSDNMSSSAPNSLPTPAQHSDSSAGNSNFLPNKMVTAAAYWVNSFSHVLSVLGPGHNPVVNGMLPVVQRSPLVMCALIAWAATRRANTGHPYEDVARVATETTILQMDQLDIERDLTDDEKEEYMWTFMIVGGLEIVKGDVKAWASRLPMIRRLLSKTLETTDFRKSQTWQALSYNCVYHDVLASLTTTSSPDFPVELYNRILGFGMSDLEMDCYMGATRVVFPFLVETAVLAGQVSQLLKQPLSPARDAQLAEVMARCEPLLARLRAVDTPIGLFSHPLPIGTDKSLLVVSFQIYQLSAELYLRSAVMRAAGSDIQCRLLAGRLLNYLRLILDTPNESQMMFPLFLAGLYISDERGRAEILGIFTKFSERVQCRNAFLVETAVLAGQVSQLLKQPQSGARDAQLAEVMARCEPLLARLRAVDTPIGLFSHPLPIGTDKSLLVVSFQIYQLSAELYLRSAVMRAAGSDIQCRLLAGRLLNYLRLILDTPNESQMMFPLFLAGLYISDERGRAEILGIFTKFSERVQCRNVFTVINLMLEVWKRDPEGDRYVDWRAVAEEVSLGVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZK1</accession>
    <name>K1VZK1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZK1"/>
    <dbReference type="HOGENOM" id="CLU_1246129_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZK1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="222" mass="23897" checksum="8B89CC7B38D38B7A" modified="2012-11-28" version="1">MPRCLAVSRASAKQAQSRTTNSATQPGHFAIPYLRELVMSQNPLMFRHQAEHKPASDSGERGCRATAGRCADRFQPKRKPSGRQERTREARSSWPGVSRHHGKRAPGLPLPTPGLPGPATFPLFALPPPSPSASSVHYKFCTSAQKGSRLHPPSSVPERFASKRFPLLLPSHVPSAARAGLLAGRTQPSSLFPLAPSLLSRCLSAQSSLRTSLPTLALVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1W036</accession>
    <name>K1W036_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000283">
        <property type="protein sequence ID" value="EKD02433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W036"/>
    <dbReference type="STRING" id="1220162.K1W036"/>
    <dbReference type="HOGENOM" id="CLU_680050_0_0_1"/>
    <dbReference type="InParanoid" id="K1W036"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45072" checksum="600F4617D310C2FD" modified="2012-11-28" version="1">MRPDFLPSPLSRLHIRRRRPLVLLGAAVLAVLLLSQVPTMLSLTRLAAMRISALSISTHESAPLPVVVPGLLAASWQGTTEDPATFLKLHIFSEDTPAGRLRRDVIRKYSPTAWVKPGTVELKFVVPGHPNALLEIDASDGDPHGEPHGHNGTKVDDRIAGIRDGRRSRNRNEITEVEQRGAVDAEADEFGDVLRVPGHDVAAEWISAVGRAESARWVVKADDSTLPLLPNMIRDLRARDWRVPTYFGTTTGRDLDRPFFYRGMMYGFSWPVAATVASARIATGTGVGDAERTGQLMWSLPSSKGMPRLLLGYPCLQTDACPASFQEDTMRPALFDRLRNMPDYPRRDDPRTGLRFVNYLGRIEGPQPWIRNDARTAIAYYGLDEEAYVEKYQRLDKAMRRAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0B7</accession>
    <name>K1W0B7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0B7"/>
    <dbReference type="eggNOG" id="ENOG502RZEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028037_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0B7"/>
    <dbReference type="OMA" id="LEIFYRC"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="121"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DNA ligase OB-like" evidence="8">
        <location>
            <begin position="344"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45767" checksum="F60CD6DFD818B9B2" modified="2012-11-28" version="1">MALFEALSTRRATGSAADRLVAGFLMQHGVHGKELETFRQLLDRNLVAGFRSRTLESVPWPSISPAHYSPPFSTHPNATEDAPAAASSASYPWTNPNRSWDISVALGLPLKLPYEVEGKLASRKYDGVRVVAIIDLVGDDVVSVRFLSRQGNEFTSLARLEEVLRNLKPQDLPRKAAYKVDALEGLEHEPLPVSDSPKYRIVLDGEVCAMVGGKEDFTASVSQIRRQATMEQPTYLVFDALTWHEFSSATGSRPLSDRLSDVRALESALSSPRFSAIKQERVRDDAHLATLVAEAADRGWEGLILRSDVGYRGKRTGDIRKLKAWAEAEFTVISRAVGRIALAGRVQKACTSLTVDHRGHPVSVGSGLSTAQRLRFVDKAEIVGKQVTVQYFEETEKSLRFPTVKRVWDGERDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0C5</accession>
    <name>K1W0C5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0C5"/>
    <dbReference type="HOGENOM" id="CLU_1361280_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0C5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="201" mass="21938" checksum="71C19A9220D2B9D1" modified="2012-11-28" version="1">MADRVHALRTGRSPGRSLRPPPVSGPSSQSKGKQPIRPNPQFEAYHNPWRLPESDPDDGFWSWLFTPPSKPSSLPSSSPSVVSAAQGKGKNSMGYDGYGVYAAYGGYDDEDDVPEAKGAARWLKPLALLFTVALLITFVALVPPPSYESRGPRPNSTLIVQSSDSDVPSDFVRELAEEHPDVEQPGDAEAQRVFRIVHQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1L6</accession>
    <name>K1W1L6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000043">
        <property type="protein sequence ID" value="EKD05652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1L6"/>
    <dbReference type="STRING" id="1220162.K1W1L6"/>
    <dbReference type="eggNOG" id="ENOG502RSBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802122_0_0_1"/>
    <dbReference type="InParanoid" id="K1W1L6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="341" mass="37092" checksum="F332035BC47F8855" modified="2012-11-28" version="1">MADSELSTRRHRMTMACQYCRQREIKCCGSAPCANCTRTGHTCGYSPVSDEANRWTRQRKAVAKAAKVTYRATRVAPSYMDVSVSSIPYLAGPGDVPAPRSFSTPGIHASPLLAYSPVPPAPAIPSHAQLEYPWLLGRPVPLTNDLPTAAVHSAMTDEEIYDADEASAYATCTATPVSSTESPASPSDRMPVTPWDKPLLNTLPHNTLPHNTLRHTSNQALFQAPSGLTYTPQPSPFSPSPLSWATYPKSPILCAGQAVQHNHPQQLNQPLLGLGIGHAYAPACYSSPLSNEYLPVFGHWPQHDEHSAYLQTRPRTNVQSSSLDSSRDELLTLDKTILLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2R7</accession>
    <name>K1W2R7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dipeptidyl-peptidase and tripeptidyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_02632</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2R7"/>
    <dbReference type="FunCoup" id="K1W2R7">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W2R7"/>
    <dbReference type="MEROPS" id="S09.006"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2R7"/>
    <dbReference type="OMA" id="YDVYDIA"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="209"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="647"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD03183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="855" mass="95136" checksum="8493ED5FE421788E" modified="2012-11-28" version="1">MAGDYDPVSPDDHRRGVALPEDDATVRESFESTGSGSDIVYRDHLDEDPFDEKTHHRQGSYDHEDGIEYPVEPTRIRPRKSSSRRILAALVLIVGGAAAIGVLAAIGYQTPTVKRGSQHITLDHIYNGTFTPKSQRLSWVSEAADGTFSRIDDDNNILLLTAQQRNKTEVLVKAEDVKDPRTGKTLEWDDWQLSADMDTFALQEPHDYPIMAYAKWSPVGHSVAFVSENDLYVVPGKELETSKPKATRVTFDGSDVVFNGVPDWVYEEEVFSTDGALWWSPQADTIAYLRSNESAVEIYDLQIFNPTDDAFNINPYTSTVQMRYPKPGTPNPLVSVHTFSLTRFEYASANGVASSAAVSQAKSTLTWPDEYPQDDRIITEVGWVGNDTLLVKEVDRPSRKGHVAVFTGGKSVGEVTRKLGKEGEQGDDGWIDHGQNIVKIETRADGSGIDGYLDIVPNADGYDHIALYAPVTASKPVWVTEGEWEVTSIAGVDREKGVAYFVAANPSIDRHLYAVTLPSSPSLVGYKPEMTPLTDVSAPGYYDVSFSPSAGFYSLNYRGPNIPWQRLKSTDETLDVVLEDNAALNATIAEFHQPVEIRSTLNHAGNELNMMTVLPPNLDPSGRKHYPLFITMYAGPGSQTVDNRWKIDWFSFLACEHKYVIARIDGRGTGFKGRKLRNPVMDNLGQLEAEDQAALAREMIKRKFVDRSRAGLFGWSYGGYATAKTLEAYPDLFTAGISVAPVTDWRFYDSVYTERYMNTLSANVAGYQNSSVHNVTAFQGQDWLLAHGTGDDNVHYANMASLVDKLTQERIRGWSMRVFTDSDHSINTRGANRELYEWMTEHLLKSWGKGGNIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2T5</accession>
    <name>K1W2T5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000262">
        <property type="protein sequence ID" value="EKD03203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2T5"/>
    <dbReference type="FunCoup" id="K1W2T5">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W2T5"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_79_3_1"/>
    <dbReference type="InParanoid" id="K1W2T5"/>
    <dbReference type="OMA" id="GNWGPQQ"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000341">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="373"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="680" mass="71371" checksum="5ECF1938ECE307FF" modified="2012-11-28" version="1">MAATPPVNLDKLRLDDEPHSDDENQTQQSESKQTHNACPALTSPSNPSPPPSPTKTSPSPHPSPAVATPAPISAIPPKPTVAVPSSATVPGQAANNLVPNSTSPNSASTHPSLSVSPQAQASPSPTSPRGPVAGFTSPAARAQLEAMRAGTRGSPAMPVAGDVRPPPPGAAVGAQRMVRPMGGPMGMRAIGNQPLPSKLPPSLQAKMDAVSGRHRAGTPAAHTALGGMNPAPAATSMSALLLQQARQGGAGGAGGDAAGGSRPAGPNTGPLGLAARRAANRPPMTLGGAAGRPAAGAGGLAAARAGVGIAGRRGPPGGLSLAQMGASTQDNRFDDFSRIMQPNGTLKFSKAVLHSGGVDFGDGQSFKINMDEMEVLGELGKGNYGSVQKVFHRPTTVPMAMKEIRLELDEARLNSIIVELDILHRAKAPEIVEFYGAFTIESCVYYCMEFMDAGSLDKLTGMGRFPKDQKEMDEPPEHAVPEDVLRRITASVVRGLRFLKDELSVMHRDVKPTNVLMNSKGEVKLCDFGVSGQLERSLAKTNIGCQSYMAPERIRGESQNQQSTYTVSSDVWSVGLTIIELARGYYPYPPESYSNVLLQLRAIVDGPTPTLPKGYSEEAQDFIAKCLVKDPNGRPTYAQMLEHPWLLKDKDADVDMAGWVAGALERQAKRGVIPLEEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4D9</accession>
    <name>K1W4D9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_01949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W4D9">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4D9"/>
    <dbReference type="eggNOG" id="KOG3691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004025_1_0_1"/>
    <dbReference type="InParanoid" id="K1W4D9"/>
    <dbReference type="OMA" id="HMEVRCR"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="7">
        <location>
            <begin position="265"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="8">
        <location>
            <begin position="562"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="346"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1288" mass="143017" checksum="7CBDD80AD9E1FDA1" modified="2012-11-28" version="1">MQRNNALGSRFNISSPQANDGLNLMGGMSDGPYPSLRPPGQSWSGAGGSDPRSSPSPSPSNASLPPARSPARRYGDIPPPAASPPSVRANGNGYGGLGHSRMPSDASTGPSRPARSQRRMEGNAPPPSQPHLLAPIRTNNLGRPDSQEMPSPISPEIPVVGTPMAEGEDPFAMDRLQRTQARKATLQTPNAALHAPSPASAALTPEERMRKAVAAFASNRKESHDSDQKAPVRRPPRRRGTTVSRPKDESWDDFYMGGGKFAEVDSVMKVIRKEWPFIMGAEFSPSTLALSLLSQQPSQTLGPHPDLYHFQDVHNGLSNALQKAVRGHFQTFAASLPTHANFVSTLDRAQDQVKSSREALKQAKEGLAGKSKAELASVRARERMVREMLQVVDQIDELKQAPEQLETWIAEKKFLQAALLLVKSMKGINRESLQEIGALSDLRQYFQSQHNTLSDILIEELHNHLYLKSFNSESRWKAYSPGQTTVPVIDAHDDQPTAPDADHSRFSQFLSHLAVKPNHIPNLDEVTANGITQNRVSLNMSRAPSMTSITSVGGTVDTSGGETDSFNYMETLLEALAALGRLGSALDIMVQRVPSEIHQIVDSTMEEVEERIEQRASDLTTMLRPTTMLLADKNDLESMPLFDNDTLRVVVSLDATGPPENAIVLRDLFWTLYSKLAAVMEGHRAVYEVARWIASRRDFKDTTKADLNLNVPVLEIWRPVQQEVRTLLQAYLSDDSQGSALKNSALPSINEILREGRLVRDKQKDLFRFGDSDARAVNGEIKEIDDSLKQTLRASVPGLVNLQAGDTGNVLGAVSGADERYSTSGKIRTLIPPNPFNVTVLFQPTISFIKRATDIVPSGFEDEMSQFGTVLEEFVENVFIPQLDEKVTASFQHAVTGYDAYQIDRRPIFGLEKPPLKSTVRVLALIQSLCAMLHESPFHRENYSRLVVGVIGQYYQQVNQHFKEVVTISRREDGSPKIGLPADWALNGDLDVVLNQIRTIAPEDVREMDRLEQQEARVEMRLCGDTPPVESQLLNSSRKLEALAHVAQSVRWFMNSLLNLQELVDDDDIDKPSLQPQEGAPKLPLTRAMAQRFESIVQFYEQLVSMTLNTLHLEVRCRVLCNLSATLRRNDYRLESEALEPDPDVVDLNATLLEMDSIASKTLSLQDHRFMFKGLGNLIDNIFIQSARQLKHINGAGARKIRRNILSLQQTLRGINTTDVVLKSIEYWDLYELGPKQMLESIGSKPDFGFDDYNAMLSLQCQENGLDLNSHLIDLHALAMDIEDWEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4F5</accession>
    <name>K1W4F5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01969</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4F5"/>
    <dbReference type="FunCoup" id="K1W4F5">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4F5"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4F5"/>
    <dbReference type="OMA" id="AMECDER"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD03743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="237" mass="25228" checksum="99F3CADBF62E02A4" modified="2012-11-28" version="1">MSALRLSSSFRVAARQASIARVARRGYADVADDKLKLSLVSPSQAVTQVNIPAATGDMGILSNHVPSIEALRPGVVEVIEEGGKTGKYFGTAQGRLLSHHWSGRQLHVAQQIPTGFATTSSITRLSIAATWSRGCRAAMECDERSPTSPWRCHIHDLGAFTLTSVSTGFATVHPNNTLTINAVEAYPIDKFSADAVRNGISEAQKVIGSSASEQEKAEARIELEVFEAINAALGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4V2</accession>
    <name>K1W4V2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4V2"/>
    <dbReference type="HOGENOM" id="CLU_746364_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4V2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="371" mass="41144" checksum="7B50275C660B8A76" modified="2012-11-28" version="1">MSSDENRHSGTATPPLPTFAIGAVAVDIEPLTRDVESVSLDDWISEQTEDEGPMNRCSNPGAASSELFERTFAARAGDQTFQSQNGTHLENRARVMSYTYPGRGARQTRTPDKTQAGSLAEGMWKNSPVEAAPTTAATYQKTESEYAFWSVSGSSRQVDEAVVQNFLGAAYVLLAAQAQASRNNQTAPATPPSLPAKTDHHLVRGEPEAKRPRLVSSGRPEQSSADARRRAMTLIYLQADPQTNEVREVRPPPRPEPEVISLLDDSDDDEVKMEDIKPRMPACDGADSALRLGQQVCLRIVQLRFTGDFRTLVSGEEMSWREVARELELEEGAARDVRKFDEWLTRRLMETGLGWRAVLRGIGFRHMKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W589</accession>
    <name>K1W589_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 30.4 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_01573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W589"/>
    <dbReference type="STRING" id="1220162.K1W589"/>
    <dbReference type="eggNOG" id="KOG1713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_0_0_1"/>
    <dbReference type="InParanoid" id="K1W589"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6 10" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="9">
        <location>
            <begin position="94"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD04098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="282" mass="31592" checksum="A220CD6C941B9E9C" modified="2012-11-28" version="1">MAARSSLAALRGGLRAARPAQIAVARGLRTSVALAQAATNEPSAPPFKEPVGVNPADYSASQVSPLHEYGQYITTCLPKYIQQFSVYKDELVLYIAPESVIPVLTFLRDHTQCQFKQVSDITAVDYPTREHRFELQVVYNLLSVAHQQRIRVKTYADETTPVPSAVPVFNGANWYEREVWDMYGVFFAGHPDLASADISRRILTDYGFEGHPLRKDFPLTGYSEVRYDEEKKRVVYEPLQLTQAFRNFADAASPWEQVGSGTPSTPENYKIPPPPPPAEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1W753</accession>
    <name>K1W753_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000408">
        <property type="protein sequence ID" value="EKC97543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W753"/>
    <dbReference type="FunCoup" id="K1W753">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W753"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="InParanoid" id="K1W753"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="208" mass="23493" checksum="6E8E172339343C2A" modified="2012-11-28" version="1">MSIIRPFEATDIQKFHTVNADPWTATYHNGYYAQYLAQWPDLCYAAQGAFEDNVGAYMIAKHEPPPPNKDHHGHLTALSISPAFRGLGLARVFMAILERLSSDGTAGWAPEPADEKEKQELGKDCVDSFFVDLFVRCNNGRAIDMYEKLGYSVFRRVVDYYHGMEGVGSTRDELDGYDMRKSMPKDKNGEYVRENGKEVLVTPAEVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1W816</accession>
    <name>K1W816_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TAT-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1W816">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W816"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000536_5_2_1"/>
    <dbReference type="InParanoid" id="K1W816"/>
    <dbReference type="OMA" id="MAANIRM"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="674"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1343"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1448"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1343"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1367"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1402"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1458"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1559" mass="169838" checksum="B00F6908908A6628" modified="2012-11-28" version="1">MSGTPRGPPEPDYNHPHHPHSHPSPNHPHSIGIGGQPSGTYYPCPSPQHHPDFHPHQGFPANLAGYPYQHGYHPSASYQVPNGVVDRHQLPSGSAPVPYLNQANQPPYFDQATNHQQSVQQPIRVDGYGNPITPAFETAPHSFSGPGLPPTFDQQAQSWQPQAAYSAQFQQQPQQQQQQIPPQPLVPTPPSDPVPTEQPHLEADSPSTATLSHPKIILRLNKPSGDMPSRSRRGVKEEATTPVADRPRRGRAAKQVNYNEDEDDGDFQDEPEEEEEDDDDAEDEPEPPVVSRPARGGRRATRRTVVEEDEDADGEAEFEPPAPAPAATEPTRRSSRSSKVPERYADDDDFENNMLDTSPVIQEVGTTRKTRRRIVDPDDEDADAPVNGTEEPVLDTAPDDTPVPQRKRQPSRQRHSSADAESFAPTESDQSSEPESPDEVVDDYEEQDDDDNFLDDSPPRRRPTRRATRSSVRATRSTRAMDSDDSYGAKRTLRKRASRPNYELPPMDISAEIQAAEIMNNAIAAASRPGGARRGGGFPGAGAANFGAAVSGKTLPWSLKGKDFAQAMGDPDSSDSDMDLPALGAGGGAAAAAGGGAVGGPSGMPGRTAGPSDVPNFGRVNPKSNMADADPLGVDVNVTFDRVGGLDNHINQLKEMVALPLLYPELFQQFGIIPPRGVLFHGPPGTGKTLLARALAASCSNGNTKISFFMRKGADVLSKWVGEAERQLRMLFEEARASQPSIIFFDEIDGLAPVRSSKQDQIHASLVSTLLALMDGMDGRGQVIVIGATNRPDAVDPALRRPGRFDREFYFPLPNIEARKQIIKINTREWDPQLPEPMLDKLATLTKGYGGSDLRALCTEAALNAIQRRYPQIYKSTDRLQVQPGSVRVQPKDFMLAVNTAAQLPPQLVPLLSESLEGIKRAVDLALPPVKKRTALEEAEFEDDDGDTFEKELMLQCFHVQSFDIATLMSDSTRTPEAAVVQLFVEAKRHQPSVIFIPSLAQWAHTISDAARSTTRALLDSIPPSDPVLLLAIVDGPLSSIPSDVRKWFGIGDESRIEIGKPSADQREKFFSELLDSVQRPPNEFPDGVPRKKRVLEILPPAEPLPPRKPTEAEVQRELERDAAARNMLFVSFSSLIAEFMRKYRRPASIVKEEAFAHAAWQAEQAALNANPPQTPPPAAAPIVPPVEAVNGEVTMEPATIENAAAETQPAGTVVVEAATTEVPTIPAVMITSACGDVSTAAPTEAGDLQQEQAVATVAKPWEAHNIDIDIIQRKLVKHKYFTPDDVLADIALIEDNANHTMDADRQLKISEMAAHARMHVQSFDPKWIPEFAHYGERMRQRKAERAKAKAAREAEKAKEQEKANGEAEAAGENGEAAPGPQIEGEAASLKRPREEGEDDNGPAKRPRDDAMDVDPATEAALETANEIAATVEPIGGVDPTVAISAEPAATNGSPAKEPTPAPKEPTPAPKEPTPAKSPSPPPVYPPLEVPDLSALRAALRDDTGLLTVEELEQLRAALLDRVWRSRQSWDRAPLVEGLEKFVRRYLDEVKLDREEEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W878</accession>
    <name>K1W878_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W878"/>
    <dbReference type="STRING" id="1220162.K1W878"/>
    <dbReference type="HOGENOM" id="CLU_967053_0_0_1"/>
    <dbReference type="InParanoid" id="K1W878"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852321" evidence="2">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="27521" checksum="1EE95118BA804046" modified="2012-11-28" version="1">MIKNVALASLVAASAVLAQDASQLHIDTPNGPVACQPTRITWGGGQPPYYVTILKGGESSGTPLADLTGGNPTSETSLTWWVNLEPGTSITATIKDSTGAQNSAAKVDVASGGNTDCISKPLSVSIAGAMATPSGSSNGETPQATDGGNQQGGGAVGGAGGDQNQQSQGGGDQQPSATPTGGDQQSQSAAPSGGNEQSAQSQSQSASQSAEQSAQSQSQSAESQSASAQSASATSAGNAASSLSSQAGSATSAAGATASSAKPEGGASALVPGFVAPALAAVVAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8S4</accession>
    <name>K1W8S4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8S4"/>
    <dbReference type="STRING" id="1220162.K1W8S4"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505392_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8S4"/>
    <dbReference type="OMA" id="FNWADHG"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="160"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="492" mass="55470" checksum="772CE3992C7F70EA" modified="2012-11-28" version="1">MSRPSEPTMQRGKLAHYAPYLAKQSQKPTPVVPWRTFLPFLPHPEKTAPPQPPRPKLKPLPEGWERSFHAAPAAYPREIREGHGDLSRSSHPYRRSPVPARESKEEKSRRQAEELNYSIDQEYAAHRWDLSEARAAAPKGLWSSVERWRRTQPRGGYTLVVTHANGLLKEQWHPALLELLARDPSAPGATFGTNQPLKHQKPVEIDEVWLMDNTNQAGSMDLNAGAIGPAQIWDDCGRDVLYFVKHVLPALRKEEDAGWHLKYTEQAPSRKVIGVGHSIGGNAIVQAAHAAPELFEAVFLVDPMCPPHPVTPEEWRRDGVKHFKLSAGALKRRDVWPSLTEARRLMADNPFYKAWDPAVFELWLSHGLVPVDYANPSGPVTLATPSWSESICFTEPAGEARGWDKLPYLPMPVGFVMAGTNFTTYGPELTQEMVWRPQRPRNERVMDAGHLITQEKPHKVADALWRFLTTYAAGEWGLKQEIQDAYAAQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8X6</accession>
    <name>K1W8X6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8X6"/>
    <dbReference type="eggNOG" id="ENOG502RBET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508243_0_0_1"/>
    <dbReference type="InParanoid" id="K1W8X6"/>
    <dbReference type="OMA" id="HHIMANI"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="405"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="490" mass="54970" checksum="127020EDA58F9AC0" modified="2012-11-28" version="1">MAWLSGGLVEAEPHLVPFWTLIVHINRTWFVKNVEDGTRKLRFKQTQWPTAQMFTIAAVPETHWAHGLVLTPDSFDMAVCSEDPSLERIVRGDNAHLFPHYDPLFAAKFAYGPPKMSRELLQAIADRQPLLYSASQGKTMLADKLREVNILGDTSSFIFPHYRLIYRQTNDPDKEAYFDTGEVQNGGLRPLVRIPGGFGRRSEDDLAGPNRPVHMQWIPAQNTIAIGHCPPAHSAELHELLISSMRSNPIQKIASFPPELTNSTYTPAFLQGKPIADPLFPGIQRRGPSVSEHLRRRAASVSSTASAAGPSNVAGSAGTRPTAKAGPTVTDSREQVETRNRLLRQRLREQVQRQRAWAAVGSDDGRVTPGTPGAPSQVVAAYEEKQYAAGRPQPAVHKIISDPRSYYKRLGMVPEPRHLQYFHEKEVDAEIKEVYRELTLQNHPDRAASPEEEARLHHIMANINVAKDHLETAEKRIVYHNRFSPTKLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9K8</accession>
    <name>K1W9K8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9K8"/>
    <dbReference type="HOGENOM" id="CLU_1541196_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9K8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="174" mass="19197" checksum="A3A9003D142D18CA" modified="2012-11-28" version="1">MPVRRIRRKQPYGGSSTHVSEQALRFQYRMRSRLTSCLGQGIAYFWLLVSSWLLNSRLNSLGLAAQLRPAPPQSTRATCATPLLYEYTRCNPVGTICPTPDVTEPPDRGSASAYWLETRASAPGSSALAAVFAGTLSVSARWFAGRLSYADQTQYRGVCPEPLLHDFPGDQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9Y2</accession>
    <name>K1W9Y2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase family 18 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9Y2"/>
    <dbReference type="STRING" id="1220162.K1W9Y2"/>
    <dbReference type="eggNOG" id="ENOG502S1N4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033184_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9Y2"/>
    <dbReference type="OMA" id="NPYFQTG"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="1">
        <location>
            <begin position="293"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="551" mass="63010" checksum="852DA62D64047E7C" modified="2012-11-28" version="1">MAGSASFEDPDREPLLRSDLEAGREKLPLGWRGWRYWLPRSSSGCRDYTAITAIPRLVRPHARRVPILILLGVILFLTGFVSHPKARASTSDFLREQSGKVMKPFHDMRPGDKAKANEIRVLKGLLQTMYPATHGSPTRDRNWGELDRLIECVEWANCTNQEKVVIGVSQHFRGGEVGGVGGEDVWARSMLNGIRELNYTFLFTSGHMDTLLVYQKIPSMVQAVIWEPNEFAHCIARNDTNYAELEAHEADADGTWQVGRKACIQSHLYPEGIPYWKSFVLHFWENPVTDLGGQWTLSPEDYSKITWNGAGNQFIGYSIEDRCLEYEVYDEREHRGLILAKEPKYFTEENGFKGILGQARDSVRPARVGGEEVPFKLVSTAGRERDADGTTEELPEGIVSLGRMPQAEYTKTLARSKMLVGIGNPKLSPSPYWGLCMGVPFINIIEDWRADDPDNRQHWRTQQDALRFTPEPYVYHVRHDDLDGLSQAMQRAATTQIGRFIPDWMRKEGQLKRIERLMETDWYAEARKVVEDKYENDPKWQHLAPLHRGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDR3</accession>
    <name>K1WDR3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDR3"/>
    <dbReference type="HOGENOM" id="CLU_1078436_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDR3"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29486" checksum="DE3E876367F88EBF" modified="2012-11-28" version="1">MPDSKSDIVDIRDHPDWQNGDFSLISADGWRIKLTISDTFRDALNADKPTITFTDPEMESKRVLSFFARLISHPADKSDTPIFGLETHLALIRFMRKHDCEHTLEVYFLYLKAALLSDRMRPMEAWVLGAVLDDSDICAAALRQETPQFQKVYWRAHCAHRYYAASPQIFNISDLPLTALSVVPPIHLHALDKVRRKNWEELVPEEQRNGYSVERLSALNASQEYAEVVAQVQRQHAAKRGESRVSSPAESAAKRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1WG46</accession>
    <name>K1WG46_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WG46"/>
    <dbReference type="FunCoup" id="K1WG46">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WG46"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_1_1_1"/>
    <dbReference type="InParanoid" id="K1WG46"/>
    <dbReference type="OMA" id="RGAESCY"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="98"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="328" mass="36502" checksum="305FD5C4193AF5FC" modified="2012-11-28" version="1">MLSASSRLRQNVPRLLKRFVSGGPSHPAPASAVWGNYTPLDPASAMAVYPEPLSVPDQIERPAYVPDNFFTHPIWEHTEPKEEEEGGPIKLGTDDEHRVRRAARTVADILAEMEKHVRPGITTEELDSIAHHLITSRWAYPSPLGYAHFPKSITTSVNNVIAHGIPDGRALEPEDIINLDLTIYLDGFHGDTSATFLLPNTDKPGRELVAATEEALDLAIRACRPGERFNVIGKTIEEFAKRHGFSVNEQFCGHGIGKRFHQHPYIIHYRNTEYGTMKPGDCFTIEPALVQGSRSRGTLWDDGWTVSTEFEHQILITEDGADVLTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHA2</accession>
    <name>K1WHA2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHA2"/>
    <dbReference type="HOGENOM" id="CLU_1008975_0_0_1"/>
    <dbReference type="InParanoid" id="K1WHA2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="30222" checksum="1BDC418E7207790C" modified="2012-11-28" version="1">MARFIGVEAPARGATRKLSHDEPTPEPTPPTGKMTLRSATRATPPPSYTYAALTARKTSPPAKKRSRPDPPVKTERSPSLTPMHQWEKSRRSDFPVPYRHASARSSVALPPPRPRRKRVLSVPEDLRHAASQVHTKLALLGVSPSEPELVRLVLPVLLGRLYDREHLWDHLVQASLKRQVTSKAPGTALLSRLNHAWNERNFRCEIAASSAANAGCGRGVCVRGGGVAAGADPRLVVVTRNGWLYELSSDNGAALDSRQTKETTQRLGSQHRNGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WHR3</accession>
    <name>K1WHR3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WHR3"/>
    <dbReference type="FunCoup" id="K1WHR3">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WHR3"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="InParanoid" id="K1WHR3"/>
    <dbReference type="OMA" id="TTLCLCG"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="76"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="216" mass="23916" checksum="D2F7BF5BBF3F0DD8" modified="2012-11-28" version="1">MTRFVKWPEYVRLQRQRVILNQRLKVPPAIAQFSNVLDKNTATQLFALMNKYKPESKQEKKARLQAEAENKTKDSTTKDSKKPLFVKYGLNHVVALVEAKKAQLVVIAADVDPIELVVFLPALCRKQGIPYVIVSGKSRIGITVNKKTAAVAALTEVRSEDAQALATLVSAAKANYLEKHNEISKHWGGGKRGNKSTAKLVKRAKKAGVKNVDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WI30</accession>
    <name>K1WI30_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WI30"/>
    <dbReference type="STRING" id="1220162.K1WI30"/>
    <dbReference type="eggNOG" id="ENOG502QTJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710161_0_0_1"/>
    <dbReference type="InParanoid" id="K1WI30"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="410" mass="45250" checksum="8982BAF1A5DF364B" modified="2012-11-28" version="1">MSDVRHADVTSVDDHHPGGARDDLSVTSVPIDARDEKEVLEVVPDEAALFASPLPITGERKTTTRTELWVGALVADSGLGPFNFAISAWQNLLYLAGTDPATGEACGDGAYGSTRSVNSIVLITNGISFALQAALFLIMGSMADYGSWRPHITTFFTLLAWGVSFGWLGVMDPSKWQAGTALYILGLIGYQGALTFWTAAFPGLARDLPEMQRSEVELKEGQIDTAEFDKRDMLARNRLANYRPGHRLPPHTSYLTAGVKQIYHAFRLCFRLKQTFIYLAAYFFLGDCLNTLVTVIATLQNEVASFDSKTLNYLLIDGIAAQAAGILICWLIQKHFVIRTKWMLVANGVFILILAAWGCVGITQSKFGFHNVWEFWLYQGALELIQGVFVANVQPTTEFSSVRGMLYRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIS0</accession>
    <name>K1WIS0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIS0"/>
    <dbReference type="HOGENOM" id="CLU_970396_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIS0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852906" evidence="3">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="287" mass="29910" checksum="34EB06FAE1ED88AA" modified="2012-11-28" version="1">MTRTHPFALLVLGGSAASAPLTPSPNSICKLTRQAHKRKVDAEVRLRAKLALTGVAHPCPAVPPTSLHAPRNLPPGAEREHEPDDEWSPADTAVASPQDPEEERVDAGDDGTCAALHVVHDASGRVAPVRAKGAVGRFAGMLALVLVVCELVGVLELAPAHAAALMFLLLVAARGLVRRPHTLAPPALEAVHVLHVRLHFVQRIVGRGDRDVAGGAVPVLVVVELVLEQLALRGPRQVALVAAEAEVVRGRHVSPAVGVCVECERAGVALQSGKGVVGLRAVSVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1WK66</accession>
    <name>K1WK66_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">A1Q2_04065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WK66"/>
    <dbReference type="FunCoup" id="K1WK66">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WK66"/>
    <dbReference type="eggNOG" id="KOG0122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="InParanoid" id="K1WK66"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="206"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="292" mass="31373" checksum="EF08A39FCC156577" modified="2012-11-28" version="1">MSKPLKSDWAEEDEFELPPTTETLGADGITTIVSWKLNDAGKKVKVTRRVRRKLQTQVVSHTVAERKHWAKFGDDKGKPAGPDRQTTIIGENLHFKIAPLNKAAAANAAAAEAAEAEAAKQPAGKAVVCRLCKGGHFTAKCPYKDQLAELDSAAAALDEDGEAGAPMGSGLAPRGAGAAAGGRYVPPGQRGGGPGESMFRPRDDFPTLRVTSLSLDADDSDLRNLFEPFASRGRLARANVVRDRETRESKGFGFVSFENKADAELALQKMNGYGYDSLILNVSWSQPREPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKF4</accession>
    <name>K1WKF4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_03847</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKF4"/>
    <dbReference type="STRING" id="1220162.K1WKF4"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="InParanoid" id="K1WKF4"/>
    <dbReference type="OMA" id="LYNCNYF"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKD01784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="570" mass="63437" checksum="F41F72F93A0E599E" modified="2012-11-28" version="1">MSTISSASSSDSGVSTPDTSVASSAPASAPASAPLSPHLKPTASTSSPAKRSAKTLTRAEVAERICAGQLLLLRDEEVLNVTNWAKHHPGGALALQHFVGRDAGDEIVAYHSEGTLDRMSKFVVGRVELDDTTGWKPLTPPIALGLRPHPDGVKGHWMREGRIRLEAEPECGTTTTSTVNHGPMGLEVVTITPNDIEPPAQPEVDLRTERKRSKAYRTLKARIEQAGLFRPPGPLAGYGEDIARYLILAGASAFLFFNTSGWLGQMASAALLGFCYQQLTFVAHDAGHTGITGDWWWDRVIGMIIADWIGGLSLGWWCDNHDIHHLVTNHPEHDPDIQHIPFFAISAQFFRSLWSTYYKRIMAFDGPSRFLIQAQHKLYYIVLSLARFNLYALSYMYLFSAKAKKNAFWWFEIAGLCFYWTYFGAILKSQTSWQMALGYLLVSHVCASPVHVQIVLSHFACSTDDLGPTESFPSRQLRTTMDVVCSEDAEFIHGGLHLQVTHHLFPRLPRHNLRKASLLVKEYCGEHGIEYLEYGWLEGNRKVLNTLQDVANQLKILKQVADKEVAEKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WP71</accession>
    <name>K1WP71_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor (U2 snRNP auxiliary factor large subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WP71"/>
    <dbReference type="STRING" id="1220162.K1WP71"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560412_0_0_1"/>
    <dbReference type="InParanoid" id="K1WP71"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="347"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="487" mass="50948" checksum="745E73310AA706E5" modified="2012-11-28" version="1">MDAAYDALDAATSSYKSSRDGAATATTVIGTTTVVTVTAATAETGTTTAAIAIATATVVTEATVIATTTAATGTGTGIGTTSAAIGETETTTVETGGATTGMAVMTGGMFTYGPGRVAPPLHLGLPSSFVSPLTQKKRIYFAGVTDAMNENRLRKLFNKVLRDVGYDGEAVSGVEINKEKDYVWVEFVSSDLAQVVFNKKDLDFDGAPIEPKRPKDFVGIDPALGFMGVSGDPNNKLFVGGLPTTLGSDEVKELLTPFGELRTFNLVKEGNGSVSKGFAFVEFLDPAVTDIAIQGLNGFQLGDRALVVQRAATTGRSASSTGVSGTAQFLAQSSILEKADEPAPATRVILMLNMVGADELYDDQDYADILEDIRDECSKFGEVEGVRIPRPVPKSTKWEPSDSAAQTAEKNRRIDQENGVGRVYVMYADTESAVKAMRALGGRQFAGRTILVASCSEEDFLGPAPPPPPSPPPAPEGDDVPPPPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTX4</accession>
    <name>K1WTX4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTX4"/>
    <dbReference type="HOGENOM" id="CLU_634894_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTX4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="432" mass="49282" checksum="B8C841AFE45BF7F5" modified="2012-11-28" version="1">MHIVAGWAEWDQRGVTRVRVVMASRLPPQTVVWLRAPVLRFPDLPNLFPVSSLTLLIINIAPPRGSSSASELQSPSPRIPFLPFDSSVALPFLSCRPLPCNPFPEYHLHPLAPIDLIYRRMMYFDWGRFPHILDTVVLAALGSGDDQLVRTLRLTHRATRDFIDHRIVQHVVCVQRPFALRTVVGRVRLAFEEPEVAARIRAFDMHMGYNMTMRPYVDHYKPFKLPNLRFMRVFSVHRDGDPKFWLPDDARGLTMIYLVTKPYNNGYSWFVFRAKTPTFASRCITLAPGAYCMKGEDDDSHSAEQNDIDAFTKLVGKSPADLSLGKGFIGAIMNSGAPVQRLSNRTGLPFYPEPPVEDCAVVGPRDLAKDMLDKFTNDRHTGQYPCRFVTLVDWRAELSDHVRRRVVADRVHPQGLLGALERLRNLRHLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WUW8</accession>
    <name>K1WUW8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000218">
        <property type="protein sequence ID" value="EKD04629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WUW8"/>
    <dbReference type="HOGENOM" id="CLU_2499474_0_0_1"/>
    <dbReference type="InParanoid" id="K1WUW8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853159" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9390" checksum="8C543230BDCA771F" modified="2012-11-28" version="1">MSPLLLILTSLRYALDALGLGHQANARQLEEHEEHRDSQEGEDKHENEARNRVQVNIGIVGVVVVMSQSAKGAQPDVPGVDDWGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WV32</accession>
    <name>K1WV32_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000196">
        <property type="protein sequence ID" value="EKD04669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WV32"/>
    <dbReference type="HOGENOM" id="CLU_1836538_0_0_1"/>
    <dbReference type="InParanoid" id="K1WV32"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="140" mass="15186" checksum="196234AEDBEFC883" modified="2012-11-28" version="1">MSGYSTALTGYSTAYEDLPSPGSADSGGYGNYNLYGAMPVTTSYNQFAPPRSAVNYTAAGRQRPNSWHVSSTPSPSFPSSPVQPAHLVPAVPERDAKFLQPPDQYFVDDAQPVGPRPSVELDIKPGFRVEFDEARRGRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1WW35</accession>
    <name>K1WW35_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000167">
        <property type="protein sequence ID" value="EKD05009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WW35"/>
    <dbReference type="HOGENOM" id="CLU_2110659_0_0_1"/>
    <dbReference type="InParanoid" id="K1WW35"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="115" mass="12356" checksum="8CFC65348C5E6383" modified="2012-11-28" version="1">MVRTQGKAMDSDPGALWDWEMMLSLTGDQVNCTGDDWHLPPRTYDLEGNTMTGAENGSPLNLFVGEQWPAPVTDSQTCYGFTLPAMNNIVGSVVPAPGVPGDQCSLAPFECFNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWI2</accession>
    <name>K1WWI2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000146">
        <property type="protein sequence ID" value="EKD05089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWI2"/>
    <dbReference type="STRING" id="1220162.K1WWI2"/>
    <dbReference type="eggNOG" id="KOG4129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326024_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWI2"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="7">
        <location>
            <begin position="727"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="916" mass="100481" checksum="21C3CFC8E5B92B1D" modified="2012-11-28" version="1">MASSIHSGAHPSSALATPHGSPGKLPSSSSSDRLFRLDADPSTQVREARCTSDMSSLPRIVRIYLCLLAKTTILEDEEAAESSLWAASLEPERGDAENRAGNADPDAPLVNRSRLERGLRILNAKKAAGQGLFYDYFTPKELSARPIYPFLPPGLQEEDLLDLCSSRSSPLACTNFIVPLPDIDLNVAPSTLLHTIVAWLYSDLFPSHFLFRQPRYVCNEDFEDVPIDMDAEYNDTWLYARISARVLTHIRTFRNSAAKGLHPYHLFSWAHDAAALAHILPVIQRQVTHFCTEQRCKLYFDVKSSFNLQRTVKACFLINGVELEIGSTLMVPEPRACDCEACEASASFINQLMATAHYQPLRNASPPLPSSPSAHHRPKRRLRLRPLHCLLVLSALCVVAVLSTILLLKGQYLRLCLPGPVYKLSPALHQKIACSPAPAPAAYAAQNATASKVSRPFTTTAAPSSTSTLASQIDIMVGRLSDLLQSQNQLFVDDLKKGHGSGWHLVNGNEAGDLDSISSAVAFAVLNTALKAQRTVPLMMTPSKYIRLRPENLLALKTSLIGPEDLLSPEDLPVSTEELGSLGVRFDLVDHNRLLPDFGDNEDKVDAIIDHHEDEERSDGAMTRLIVFPTGSCSSLVTKHFQPEWQASISGPAGIAGSPVPRELATLLLSSIMIDTHGLKEGGKATDVDRAAAAFLYPLSTFVDDNKVIALQSIAGDQVPDPLLRFGNELVEVKFNVTGMSTHDLLIRDYKQYVWHPKNTKKVQVLNIGLATVPMSLKNQLKQEKDDWTTYLQTCDSFMTEKGIDVLGVLTTYKSEKKGKSKREILLVVRPGGSIPDAALCRYVSDTLAAGMERTGGVLDLLPWEGKGKKLEYADKFGEVAVGHDGRVARVWEQGNAKSTRKQVAPAIMDIVHDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WX30</accession>
    <name>K1WX30_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WX30"/>
    <dbReference type="HOGENOM" id="CLU_681839_0_0_1"/>
    <dbReference type="InParanoid" id="K1WX30"/>
    <dbReference type="OrthoDB" id="10677031at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="403" mass="46348" checksum="4B9A7302BA77DE45" modified="2012-11-28" version="1">MPPRKRKSTSSSRSRSAPEPAPALVKRPRTRLYKKQNPLHIDHLSFPHIIDSILEYGGWAVQIKFRATCKAFRYRVDSQVAKHIVVRADERFAYSTSPNRRIISFHSPEGPIRGFQAMKEQQLLDIATSRRNKDRWLRTIFQHVEVLDIVMNVPLPVRTVLGSLAAAPRLVRYVRRYHAPNSELERSDFFTKVQAPTVVLYPGMRLKHNDAGQHSPAFTRLDVPEGPMQRLVIQHHFRRYQSLNHQRQYYAVSSKRQALKEIVVLFSLPDPDVNSQPINWDGHVMQNRNSLFTMICGLALDQHPDTKLTFVGLESIPPGDFDFRPGTPFETVKEHLALGVRAKATRQTWYPLKPENVDATLNKIRYLTLEEYRAEIGETQFKAEMDASPPPPPASEQQVQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXW7</accession>
    <name>K1WXW7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_00275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXW7"/>
    <dbReference type="STRING" id="1220162.K1WXW7"/>
    <dbReference type="eggNOG" id="ENOG502QTWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="InParanoid" id="K1WXW7"/>
    <dbReference type="OMA" id="PKYVGAE"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD05514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="351" mass="37123" checksum="E2AF1E8D84B66AF4" modified="2012-11-28" version="1">MAVISTPLTELFGIDHPVILAGMNVAAGPRLAAAVTNAGGLGVIGGVRQTPKILRQNIKELKEGLDRKDAPFGVDLLLPSVGGTARKTNYDYTGGQLDQLLDVIIEEGTKLFVSAVGVPPAYAVEKLHKAGILVMNMVGHPKHVKKALDVGVDIICAQGGEGGGHTGDTPTSILIPACVDACKGRTSPLTGKPIYVVAAGGIYDGRGLAAALSWGAQAVWVGTRFVASVEAGAPKKHKELVVSAVFGDAERTLIYSGRPMRVRRTDYVKQWEKRQDEIEKLCSEGKIPHEVELSKKPELSMPGRAWLMGSVSAVIDQVLPAKTIIDNFVYGAKEVIEANNAKLVGGARARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0D2</accession>
    <name>K1V0D2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0D2"/>
    <dbReference type="HOGENOM" id="CLU_1338370_0_0_1"/>
    <dbReference type="InParanoid" id="K1V0D2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="205" mass="21398" checksum="12F55B70C2744366" modified="2012-11-28" version="1">MTKARFDDVGGGREFGVRVLESPSSLFCYPRSSSALPALIKSAADRYPVVGDPRDFAPCSLPASPAPTSGLDLDDYRNPTASFSDSQAVTLSYLSLTQCAAHFPPGTYGCAQVWSIPAPPQVPAGSVTSTDDRARFRPGHSQVVGRPGLLVSAAPSPHTPVSVKPVSDAEGTASRSNVVRLFGVDRATEPQSQKLGVGLGVGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1B0</accession>
    <name>K1V1B0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1B0"/>
    <dbReference type="STRING" id="1220162.K1V1B0"/>
    <dbReference type="eggNOG" id="ENOG502R51R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327054_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1B0"/>
    <dbReference type="OMA" id="CRPNISK"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="857" mass="93787" checksum="3640BE33B3851774" modified="2012-11-28" version="1">MRPLNGLARAVFVSERRIASARPPPGPSCSRWFSCTCCANDSRLRRKSVVHPRAPVPPIAILQQMQMPNLPLPPPLPWSPDSQPFLRHMHKLSIAILSESPDQSWEIYTALHPDMLKDVPDDVFSALLNHQLQADDSVKGGRLGDLLSLAAQCDMDAGALGLSLVEEALESALTSAARQIRGPGGVKRAIDYKTMDWLWGSLKNLVGDDLSHVSLVIRREWLVVSAFRHRNNIPLVHQKLEELIELGGGEGLDEQAGRIVSMAKHKSTDLLESSLRLAAWCLARNINIRPLLISRTIGHLRQAWKAQGKDGAERSQSTAMALAAELREGGADAAAAVFESVVQGIVRKMLPVEGRVRMLADTASTTDDVYKVASGILTKDMTGAADLEALVKLCHLAMAKEGNAEPLIRRTVKLLASRPAELDHLVFKLADDVWSFSRNGGRLSPPLLTRIFDLVLACPISDNSYRAAYRLYPLVRAADPPEQHRWLHSTAPTWNRLFAAAVSHGQIFFASRLYADFQSDGLTVPKQQLLRLIERIAATETVSRAILLDRHVKDYLWDEAPPSDLITALVRGMSSTGSRSAVEGLRLAKRISPDQLPVAAIEAALPVLAASSHRSRRALAFALLKELPTDQARTGYERVLSALVKNSRAAGLEPVLAVVHDMFERGIPAAEKTSSLIISALLKNGQVDAGMATFRAAVSKNIALSSRAVGQLMVNLAQAGRCDDAYEVERTWRALTDEKANDKAVRGARLLVDIKAGRDVDLDVYTCDDGGTKEHAGYRPNRHYLDFLRKLRAPEPPVEAPEAPGAAAETSKHTPSGAPAYSPVETQRRASRDSRHEDHLDKMERTVQPVTTGQVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1J7</accession>
    <name>K1V1J7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 8904</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2012-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yang R.-Y."/>
                <person name="Li H.-T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.-P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1J7"/>
    <dbReference type="STRING" id="1220162.K1V1J7"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_1_2_1"/>
    <dbReference type="InParanoid" id="K1V1J7"/>
    <dbReference type="OMA" id="KGEYMIS"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851549" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="420" mass="46183" checksum="6104B0537B32070E" modified="2012-11-28" version="1">MLKTSTAFVLLASLVSAAPTALDKPLTVPLSRDVAKPAASPEEQAFRSDVHLLSKWPQLLYPEARSKIRSKLRSKTQGDAVTEDLNNFYDVTYTADFQFGTPPQSFPVIVDTGSPQFWLYSEKCVGCGKGHVDTTKSSTFHSTGRNLTISYGEGDTSVSGTWGNDRIGFGGIFTDNATVGIMDESVKMNLQDISAGISGWSWPLTRNGTTLEPLPWVQATKGQWKNKEFGMYLNRQGFGAQLQHVNSTRPTGALTVNGVDRQFFDGELEYFPRKVLDERTHFAWGIDLDGVTVDGKFFDTKGNGAVLDSGTTLIYGPKDVVTEIYKQIPNAIDTGDGMFILPDCTTNHTVSFRFGGKEFPIFSPDFGSVSLFGCQGAITYAEKLDFKNNWLIGDAFLKSYYTAYSYDPPQVGFAKVKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V341</accession>
    <name>K1V341_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V341"/>
    <dbReference type="STRING" id="1220162.K1V341"/>
    <dbReference type="eggNOG" id="ENOG502QQW7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_1_0_1"/>
    <dbReference type="InParanoid" id="K1V341"/>
    <dbReference type="OMA" id="GVYPRIM"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="342" mass="36301" checksum="3005BBB707DCE192" modified="2012-11-28" version="1">MAIQTELTRALGIKIPLVQGGMQWVGTAPMAAGVAAAGALGILTALTQPSPDALRAEIRKTREMLKGTDGKFGVNITLLPSITPPDYAGYVKAAMDEGIDIFETAGNNPGPIIKLIKTYVPAGQSSVPKRYVIHKCTAVRHALSAQKLGVDMLSIDGFECAGHPGEDDIGGLVLMARAAEELKIPFIASGGIANGRGLAAALALGAAGANMGTRFMCTKESPIHQNIKQKIVDSNEKDTVHIFRSLKNTARVFKNKVSVEVVRLERRPEGAKFEDLRDLVSGARGRTVYEDGDPDAGIWSAGVTVGLIHDIPSCKELCATIERDAEQVINGMQKLVTPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3A1</accession>
    <name>K1V3A1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3A1"/>
    <dbReference type="HOGENOM" id="CLU_708208_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3A1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="390" mass="42164" checksum="F3B28BEFCB504B61" modified="2012-11-28" version="1">MIPATTTTPRPPVVSRQVALDASTPLPLAPRSPTLPKNHPFANSLGRSRSNSNVSGRSGSAFEREKESVYSSSSTSTTTIRTPPTPAVQLPPALRSSPPPRSPLSLAASLPPTGPPPKSPSKSSWRKKPSITIPFRKVSSSVSAGSTPTSATSTRPAPAYSSSSQTQSAPAQVELVFDSVFEEDDVARERFCPQVRWLAGELCVKPDKDSPRRRLARYPAPLPPMQELAREFSGLGLNIEPPAAKSPPTPSAATPIPTSNVRSGVSPSSGRTPSTTYPQPYYASPPNAMLQMRRPSAPHPFYAGPPAEEERQRPRSQPHPKPERHHTHPPPSFAGHHQRSHSEAGTMLAPNCSQHRPSKSLMELDFLNQTRSKGYMFGSVKSRLRTIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4I1</accession>
    <name>K1V4I1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4I1"/>
    <dbReference type="HOGENOM" id="CLU_432919_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4I1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="632" mass="68296" checksum="1AE593633098420C" modified="2012-11-28" version="1">MSAHPTGGIPSGYPFDDHYVDPVSENGTWSDEDEERKASSIGHDDHADMESLFGGYDEDEPSPGLHMDSPFTQAIDVAIREQLAEPPIYADSPGYANAQTPVTPTRCGHVNDEEEIRQDSDSLNSEYNSANDSWVTAPTPETPCPSRSARPSRQVQKKVYSEVLEDLTEEGDEDSDEEDEEDEEGAEEDEDGDDGEADEHDNTHEVGGEAEEDDMDAEEEDDPDYVPPVAPSPALTAATSIPDIDAWRAGCRSGPSTEEASNNIRSPIVRSRRSSASRDALESHIESSRAHLRRERRRFERAESRVSGFSDDEDDEDDLIPRQSALNAVGIAIANISRHVFRRPKTKKFDKEPENRRPDTPSGSRGPRNRSDSVVSGFPLPAPGSLAASTSKRRSSSPVVSSRRRLTINTSSANHDVSLPPGSAIFLPGGPASSPAGGAMVPWQQAATGISPMNTALNSLQQGLNSLGVGTPTIPTFGLTATSAPIVNISIQNNFHLAASPIQPVPPPDPFLTGAQDALAPFNPLQPSAERAGDEHVIGAQGEDMRVPAHYNPSSQNCVCLPCSVRRAILANPDSAMHLRDARQEHHLMLRTSPAGRTDWRAFANRASGERTLGTWQSFISGLPPHDAIILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V609</accession>
    <name>K1V609_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V609"/>
    <dbReference type="HOGENOM" id="CLU_1908173_0_0_1"/>
    <dbReference type="InParanoid" id="K1V609"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="142" mass="15627" checksum="6B15A683E1D84833" modified="2012-11-28" version="1">MPAQVLRDYHTYSEQRLRSVGDAAVERGQQTFSETFLPSVSSEIHKQDVCSRLSMAEQPALKLQSPSGDILYEGYMNRFPTDLESHLSGVLTRLQVLNLPFQQHVDGSTLVLVATVDGARGTAATAKGRYVLSGSWESARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V662</accession>
    <name>K1V662_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_06231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000371">
        <property type="protein sequence ID" value="EKC99499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V662"/>
    <dbReference type="FunCoup" id="K1V662">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V662"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019224_0_0_1"/>
    <dbReference type="InParanoid" id="K1V662"/>
    <dbReference type="OMA" id="AYTGWID"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC99499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="520" mass="55944" checksum="0102821CB9F491EC" modified="2012-11-28" version="1">MSRPSAVTLPAEQSASAASWLTLPNAVPLDLVVLQSAPKRTTEIFPHAPSAAVRCVDREFLVVVSCGLPALPDDTGLSSNSNTVEGEKSASGTEGAKDSTNGGKVLAAAISAHVYTLPNSAAELVYISKVDSSGYASACGPLTRVLASSFISYFLEAPGTVAATLFARAQGQYLFPNSVEGGGKRVLGGLGLCGWWKRVFEDAASKVIEAEKRPVVKPRQVELSYLLPSYSAAEARGMLPAASALPAGVKWDYKPPFTHRILPGTSLATLIPSLPDDPKTRFLEELVDDALDKEPYAVRERRRSSQAKQPEDSKDENGEKSDANGEPKDDKEKERAKLSRKERETEAEEEERRKAYAALENVPTDEFWERMGFRQECASGDVTGFFHVLVVPDPEGGDASSFVAAAEAQQLAAESKPDSKPESSDSSKPPASGKDAHTLPPALVERILTSMLNTDFGNRQLASSGTSFWTQATKSLVVDAIGEKGWDACFGSIAAKQGVQREQKRKEETVTMLQPRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7I4</accession>
    <name>K1V7I4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000354">
        <property type="protein sequence ID" value="EKC99959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7I4"/>
    <dbReference type="STRING" id="1220162.K1V7I4"/>
    <dbReference type="eggNOG" id="ENOG502S46I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="InParanoid" id="K1V7I4"/>
    <dbReference type="OMA" id="MDGTFNT"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="217" mass="23554" checksum="FEF89285F2123108" modified="2012-11-28" version="1">MTAKLCIGALVFPGFQSLDLFGPLDIFNTLSLKHPIELSVISTSLDPVSTQWKEGQVAQSIVPTCTLEDARTDYDLLIVPGGFGTTKDVDPYVDYIKRAYPTTGSVLSVCTGTRLFARAGILDGRRATTNKNAFNDVTPLGPKTHWVAKARWVKDGNVWTAAGITAGIDATLAWVEDKYGAQQATDAANWLEYKRTSDPDDDPFAAVRGIEDVLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9D1</accession>
    <name>K1V9D1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clathrin-coated vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000413">
        <property type="protein sequence ID" value="EKC97335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9D1"/>
    <dbReference type="STRING" id="1220162.K1V9D1"/>
    <dbReference type="eggNOG" id="KOG1822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_449181_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9D1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="608" mass="65180" checksum="DE35C59FD18935DD" modified="2012-11-28" version="1">MISNAVLTSNPNEVPGPVQRRHLEFSPGSGRTSVTAPAAPRASPSTEASRSDEDSPYPPSDTSRLPPTSSAASPSASMINTCPHADLLASEIFDTTTPSQAVSHSQPLPRPAQPRSHDDSRPHAFPSQLDSYARGTATIASMRELQVSYDDLLERSEDLRSKYAVLHTRVKRVQGRFQKLAAQAKARSRGDYNPLSDYRPPFQSPLFPMKSGTPKPFKRQREVQESEPGELLMSPSQKRMRSSTCASAGLKGGCAPAPSSTSPSTSKKSPSAPQSFCPRATLIVRDFLSSPSSLSSPNPPSSASPSPPVSPGPPSTCPSAAPDGFPCANCVFWQSQAESSARNKQILSSAREMMSECRLMHAGARRMRVETAVMKIRTEHVHERVQKLVGKAGAAKYIREVAEELEPGLKVGDACQKVQAAAEVGAPPYVEPSSATESMQPALLQAAVTVFADPENYSGSAAQAAIAAQAGQFTSVWASTDGYAFGVTSLLKARERERGATEEDVFLNRDKIEMAFESQLNHPIIGSAEHDYVDLFNAEAMTESPKPVPAQTGVIDAGVQLCRLAFSPCSLRTLKSADLSCSSDTAISLRSRLFSAMIGLKPKVRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9N1</accession>
    <name>K1V9N1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000335">
        <property type="protein sequence ID" value="EKD00665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9N1"/>
    <dbReference type="STRING" id="1220162.K1V9N1"/>
    <dbReference type="eggNOG" id="KOG3351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035272_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9N1"/>
    <dbReference type="OMA" id="HIYTALW"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="136"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="33761" checksum="30BA8E0DFE688BF5" modified="2012-11-28" version="1">MAARNSVLILPFTSGILKDPSSLLPVIFDAAQEPTESLTVVFSTPGSGKQLYAELREAPKAHFEELQRFLGKVYAALAAGQWTANRVLLNVEVRFDGELGDWSEKLQALPDEVVRLEGDAKLAPWTPVGGYPVSAIGGTFDHLHAAHKILINMALFVSEKRLIVGVMSPDQLKSKSNAGVLEDLDTRIGGVNAFLKRCGPGDIQLDVVEIQDALGPTAWDPEIEALIVSRETMSGGAYVNKVRKEKGLGELDILCIDVISSIVAEEAGTTVNLSEADGEQLKELKMGSTAIRGWIAEQKKQHDLEERVNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9R3</accession>
    <name>K1V9R3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_08212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9R3"/>
    <dbReference type="STRING" id="1220162.K1V9R3"/>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816809_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9R3"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="340" mass="36487" checksum="496582AA3EADAFB5" modified="2012-11-28" version="1">MNSTLPLLSLLPNGNYSGSASLGDNNNFRSYDYVNSGEDNNGSNGGQTIDFGSYGYPDDLSFSVSHPSYQRPSSGHGQQNGGYPHLVQPDFSNQYRADHGHHGSHHGGHGGHSEHHHAQHSHSQHQHHVMNDHRNGSMAVNGGDASRFLDLDLSQPGPSSYGHGANGLYSSSEASHEEANGYVDARREDELVKVETSKEGTAPAAEGEDADNEEPLYVNAKQYHRILKRRLARARLEELNRLVRSRKPYLHESRHRHACSRPRGKGGRFLTADEIEQLKREEAAKAEAGESTAPSTNGDVTDSAPNTAANSAAPSKAPSDAGDANSNTGSAPASNEASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBR3</accession>
    <name>K1VBR3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000393">
        <property type="protein sequence ID" value="EKC98230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VBR3">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBR3"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000366_0_1_1"/>
    <dbReference type="InParanoid" id="K1VBR3"/>
    <dbReference type="OMA" id="AEPLSQF"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1734"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="853"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1268"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1441"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="853"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1186"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1209"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1301"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1462"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="2053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="2086" mass="225342" checksum="76711A36EBAFE6BB" modified="2012-11-28" version="1">MDRNKNNQPSSSQHQSSLAYHQAPSTSTPTAQTAPVSYHSNTVTSPPSVPNAPVSNESTASANVRITRAQHRQASSSSAATSAEAPPPATPTPVLPRRSARLSSNYNQASPEQQSTPSSKGKADPSSSSTSSLSADRKGKKRATREPTPPRSDPAEDAEPAPKRSKKSPAKRGKGKAKATPKPKMPKKTAGKKGDTSARQLIDDNMDEDEHHWGESTSAFLDDEHYREDEDMDESDHDEDEEDDDDEDEHRGSSAYDRLARLADGAMFDEATAAALFGGEYRAFGGFMSGLSSRFKRLKENLRSSKTSKRLAALRECSDLLLVSNEDTLGASFSTSAFATEFIAILSGKPNIDSQRDGDEQMGESDEMDEDAQLAAALAMSAGDAFPEGDQEDMECQLLACRCLAHLMEALPGSGHTLVHLGAVPVLCSKLNEISYIELAEQTLSISAEYPAAIVREGGLAALLNFLPFFSTNVQRTAVTTAANCCRNISGEHFAMIRDVFPILREVLTQTDQRLVEQATLAVLRTLESYRHNAEHLEGLLDLPTVVAINALLMPAGGSPIISDSTYTHLLKALTSAARASAKVTIALLEAGMTDTVHYILTGVLPAANEQEEQGDAPGGQGLGGGVADMAVMQNLAHRPKDQIEEALGLVCELLPPLPRDGVFDHRAYSEKSLAKLQRRSRPSSSRRSSSRAEGGSGSPGEPAEASSVPVLGSYPPGKSRRDVEALNEQRLTLLKSQPELVSKFMRCLMPVLVDVYAASVSLRVRTKALTGLTKATAFAEPGDLKQTLTNVPMSSFLGSIISSKDNPTFVLHALQLVELLAGKLPDVYLTSFHREGVVFEIESLAEADLSTKVKEEREEAKAKEEAKEGNLEDSPTTPRAGQAQESPTKSNVGELSGVLANLISSQTSASHRIRSSSVVDPNDANILRARVIGAKRIFAVDDTQQNEASLVLEELTKLVERLCHPEATEPELRDTLREIAAQFSNVGQALSSFELLKSGLVDGLLEYVDIDGTVPSSARRDILFEIFSDTAVASPSPLVMLVKRLHESLGRLENLEVETAFNGMGTGSSSLARSMRIRLQAEEGEDIPKQMSALSVTIQAIAPVQALHDYLRPRVADPNYLSGNSALQNMFAAYAASRGGGGGSTSRLLAALAAGSRGVGAPPGTRDEPSSSTQPPQSQQQQSSESKETKEDAKPQRRRSARLSGLPPDAESTAADAATGEAAAGPSSGAAASSEPAVLPQMPVSMDFDDDYSEDEYDAEVFEEDMEEELERPTEKVVNMSMAPDGSRVEAQTPDGTRIATPNQAASSSANAGSSSTPSRSSYAGAVKTAPVDWHLEFSINGQVLSLEDTVYGAVHKYAKSSSSPLSAFNVPVTFKFRKVEGPASAKAPVDAPSPASISSTLPPVLDPAAPVYSEDEYDAEVFEEDMEEELERPTEKVVNMSMAPDGSRVEAQTPDGTRIATPNQAASSSANAGSSSTPSRSSYAGAVKTAPVDWHLEFSINGQVLSLEDTVYGAVHKYAKSSSSPLSAFNVPVTFKFRKVEGPASAKAPVDAPSPASISSTLPPVLDPAAPVSKILRLLRVVHTLCVEGRDTLMRVDVPDESLFVNNKLTAKLARQLEETMILASNCLPEWAVELPKHFSFLFPFETRYSFLRSTSFGYGRLIAHWQASQPRSNSNSRRDDNLAHLGRLVRQKVRISRAQLLESCVKVLELYGTSNGILEVEYFDEIGTGLGPTLEFYSLASKEFSRRSLHMWRDEDTSKEGPYVFAPNGLFPAPTSEKIKNAPSSKHSYFKTLGLFIGRALLDSRIIDVNLNKVFLKLLLGKPVRKNIATLKQVDETLARSLERLQTYLQARQEIESLTALPASSRRNKLSALTIGGAKLQDLSLDFTLPGYDIELKPGGRMIDVDDSNLEEYLELVLDKTLGSGIAEQVKELQVGFSMIFPINDLGIFSPEELALLCGNTDEDWSKETLEQTIKADHGYNADSRSIRNLIEILSAFDSSERREFLQFMTGSPKLPIGGWRSLNPPFTVVRKPHEPPIKADSMLPSVMTCAQYLKLPDYSSKEVLATQLWRAIRDGSGSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VC16</accession>
    <name>K1VC16_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VC16"/>
    <dbReference type="STRING" id="1220162.K1VC16"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_980676_0_0_1"/>
    <dbReference type="InParanoid" id="K1VC16"/>
    <dbReference type="OMA" id="WENPLAP"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="284" mass="30771" checksum="F7865CADF73A7A46" modified="2012-11-28" version="1">MPPKGSKKGKGGKKTDSAENPPLPAEAPPLPDEAPPLPDEQPAVPTDAPPLPVEAPPLPDEAPPLPVGEDAPPLPDEAPPLPDEAPPLPDEQPPLPDEQPPLPNEPVTELGGSKEKDANPAHAWQAVWAPEKNAYYFWNTETNAVTWENPLAPASSSSTPAAGSTAASASATPGPSVPRGGLPDIDPELAYLLPSESRDAAGTQLLAVSGRFQQRDDGAFAARDEYERQKRFGDAYFDVEGWEKERGKRRREEEQPRKVTKKDMERFKAKKAEKTRRARAWLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCR9</accession>
    <name>K1VCR9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCR9"/>
    <dbReference type="FunCoup" id="K1VCR9">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VCR9"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCR9"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="714" mass="80094" checksum="A30951FA9B7A4A38" modified="2012-11-28" version="1">MGLLALGTPLDWPDTKPLAEHIRTHGIKQFLHTWRRWQDKSGAGLLWGDEIEYLVVAKDEEKPEDAVRLSLRQSEILEKLAKVTMDPKLEASMPKKCDAIPTFHPEYGRFMIESTPGAPYTGSLSDLVRVECDMRWRRKIIRSHLLPNELPITLTSWPRLGVEDSQFTDPPTYPDPEHSSSRSKYVAQLITNPHARFPTLTANIRQRRGSLVDIRVPLYIDKNTKVPEGERAELSNGHAGPAKPLPGTPYIHMDAMGFGMGCCCLQITFQAWNVDEARQVYDALVPVAPILLALTAGAPAFRGRLADVDARWNVIAAAVDDRTEEERGLKPLKENEYRIPKSRYDSVSLYIADDPRNKPEYADISAPINQRVRQELLDNGVDDKLASHIGHLFIRDPLVQFSETIDQNDEESMDHFENIQSTNWQTVRFKPPPVNSNIGWRVEFRPMEVQMTDFENAAFSIFIVLLSRAIISFDLNTYMPISQVDENMQRAQQRDAAVANKFFFRRVMFPHGIDAYNLDSRPVSRPVSPPKSPPNEKSSPVSENGDAPSLANGKPAVNGFHKSNHWRYGSTASSSCASLQQEEDADHSPEVVEMSMDEIINGRKDGFPGLMGVVNAYLNSINADVAVKMEIRKYLDLIKLRARGDLVTPAAWIRKFLTSHPDYKQDSIVSDKMQSDLITAVDEIERGIRPAPELLGPHYVGTDVGSPAGCNGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDG1</accession>
    <name>K1VDG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDG1"/>
    <dbReference type="FunCoup" id="K1VDG1">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VDG1"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="InParanoid" id="K1VDG1"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="484" mass="51447" checksum="5D2A6D176B9100D2" modified="2012-11-28" version="1">MLSLARRHAINSARLQARALRTSAPLAELAKFKMPAMSPTMTEGGIASWKKQEGEAFAAGDVLLEIETDKATIDVEAQDDGVLAKIVLALRVVLGLRSGCRQLPQGWERLTIAQKQDGAKGIPVGTIIAVIGEEGDDLSGADKLAAEPDEVESIPKEDEAEAPAPKEEEKPAPKEEKKEAPAPKKEKKAEPVGGDMPHFFASPIARKIALERGIPLGQVKGTGPEGRITKEDVEKFKGAAAPAAGASAAAAPAAEYVDEPTSNMRKVIGKRLTESKQQIPHYYLTVEINMDRLLKLRSVFNKASEGKSKLSVNDFIVKAAALALGDVPEANSAWLGDTIRTYKNADISVAVATPTGLITPIVKDAGHKGLATISAETKALAAKARDGKLKPEEYQGGTFTISNLGMFGIDHFTAIINPPQSCILAVGATTPKLVPAPEDPKGFKTINAMNVTLSSDHRTVDGAVGSKWLNAFKGYLENPLTFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEA8</accession>
    <name>K1VEA8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEA8"/>
    <dbReference type="HOGENOM" id="CLU_1125212_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEA8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="247" mass="26798" checksum="1EB1A4ACF8B58243" modified="2012-11-28" version="1">MGNSNSKPPKQGLKVPSIILEENVVRHFLAPHLVDGRIPTPIEEGAFLAALEALTAVEPRMRHYNTSFRARSLIKACDEFHDRLYAVYCELQNSGSIDSIAPAEPATSDTPAGAGNLQRPASGVDSDPDPQPNALAPSSQTQPCPTTETTVSAISTSTCTAPQTKDVEERCPSNVAEADEDQDHVCAKVQSLESKVARLERTVSLLTKMIERSRSIRQNLQKQNAHPIKEAKDDHVDPPKPSDTNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEL9</accession>
    <name>K1VEL9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Coenzyme A transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_03225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000282">
        <property type="protein sequence ID" value="EKD02465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEL9"/>
    <dbReference type="FunCoup" id="K1VEL9">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEL9"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="InParanoid" id="K1VEL9"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="140"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="247"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD02465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="338" mass="37484" checksum="FC5173574248F160" modified="2012-11-28" version="1">MASHSAGDKVSPARDMDTVHLQRPSDLRQAWLESRHRAKTDKSSWDYIITSGIVGGIAGCVAKTAIAPLDRVKILFQTSNSDFRKYAGTPAGLIHAMGKIYRTTGVLGLFQGHSATLLRVFPYAGIKFMFYDWIEKRTPGRFFLAGATSGVAAVMLTYPMELVRVRMAYQTSGTERPTLRHAVRSIYEEARGNPGVSPFTRALPFYPFYRGFSVTLLGMIPYAGVSFLTYGTLKTHLPKYVPYLRARPTQRDLLCGAVAGLISQTCSYPFEVVRRRMQVGGARGGPGINWRQAVGSIYKASGWRGFFVGLSIGYIKVIPMTSISFATWQFLKRLLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEN3</accession>
    <name>K1VEN3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEN3"/>
    <dbReference type="STRING" id="1220162.K1VEN3"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399664_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEN3"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="689" mass="73130" checksum="CD4CC7865931650D" modified="2012-11-28" version="1">MHESEDEDEYDEEPTPKAIVIDEPATKPTAELEVEPEAEPEQDADTSASSGSSGDSSLRRLGEGVLGFLAGLVSTPAPAAPAATAPAPVMAPTVPAAVQGANKQAKPVRVIKNKPVRAKGKENASVKPRTRPESKPQPVKTGETKNKDMPRYALATAAVRAHGQEKQPTEKRKRDAGSPQRNVRRKVPAASALSTRPLRSLPRAPLGSAPKETASASSRPIKSMPSTRSSGAAARSTGASRSVSATSAASSSSSTSRGPRTGSTVTAFTAAALARLPKPGETKAKSSPVKIRDLERARDLAVRKAVFERFHPDADVSLSNMSFGSTAPTQPTPAPLGESSSSNTGTTSRPMPPTLNGKAKNLTVPMSGKTPGKASKMRAASRAKFDAKVARKAALKAKEDEERERIRRQVEEEMDRERRRATVIRARPLPEMYRAVITGASSGIGASTAILFAKAGLNLVLLARREDALQKVASDATAAAKEFGFTPQITVKTLDVNDRAAVDALPKALQDAGVKSFDVLVNNAGGAVGTERAGDVQLKDIDFMVDTNLVSLIQMTQVFLPTMRKQDSGHIINIGSLAGREAYVGGSVYCAVKHAVKAFTQSLMKELVDTGIRVSEVAPGFVETNFSVIRFRGDEDKAKAVYKGFEPLVAEDIAEEIVWCALRPPHVNIAELYVLPVAQGSATIIHRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFS3</accession>
    <name>K1VFS3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Constituent of 66S pre-ribosomal particle, Mak21p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFS3"/>
    <dbReference type="FunCoup" id="K1VFS3">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFS3"/>
    <dbReference type="eggNOG" id="KOG2038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFS3"/>
    <dbReference type="OMA" id="EIWCNDE"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="610"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="887"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119044" checksum="8668200EDF6514FA" modified="2012-11-28" version="1">MAKGKSRATSKADKPQKPVKAGKPASKTSDNEALRQAVKELGGDDDDLDLIAGVDSDDEAAPANKSGNIDEKALKAELGAFMKGLDFSSLAPQAANDDDDEDEDEDDEEEEEDEEDDEDDDEDGEDDGENDEDDEDEEDDDDEEDESESEESSEEEAPKKVEPKKGVKKEQPKKEEAPAKRNVPLVADWSSLVPELAMPSKPLGKAPHSKINSLRMRADQLLRDLPKPQRAGSSSDTAFISQILSSGTHQDKLSALVLLVRESPIHAISELERMRAMAGWRDGAPHAGGGRDERLATVRALADWWVTGGGKENGKLKYFADQPLLAHPDITDRHLVVYAFEDFLKKWYFNLLQILETLSHDTLPYVRSKALDVTFQLLQGNAEQEQNLLRLGVNKLGDTDRAVASKASHHILQLLQVHPAMKAVVAREVAAIVLKTTLTGAAGSSSSGTHMRFDDDEPKKKAEDGAKAPPNHGRYYGLITLNQMTLTQKDREVAGRLVEVYFEVFREILGEEQKKGDEEKAEADELDAEQMQKVTGKVEKWRGRRKGAKPKGGRKQPEEELVDSAEAKLVAAVLTGVNRALPFAKLDDALFEGYMETLFKICHAGTFNTSIQALQLIFQVSQSRPSVVDRFYRTLYESLFDARLITSSKQAMYLNLLFKAMKADQSLPRVMAFVKRLLQMLNLHQPPFICGALYLLGDLFNATPGLRRMLIEPEDDGEEHFVDADAKGKKPVAEKAGESSKAAEKQYDGKKREPLYAHADQSCLWELLPFTEHFHPSVALQANQLLMGQTLTGSADISLNTLISFLDKFVYRNPKKTLQPKGASIMQPAAVNDTTGNVIRNRGPRTAPESNVNTEAFWRKKVEDVPVDQLFFHRFFSTKLAKKEALKKDAKKRKGEDSDEDAMDVSDDEMPSDADEAAAGSDAEEDEIWKAMQASMPDAGDDMGISDDSSDEDVDYSSDEEGDDAAEVDEDDDDEDEEDEENEDEDDSDGDDFPDLDEDEDDLIPLDEMPNIELGGSESEEEEEEEDPVAGAKRKRREERKERRKKRREMPAFASAEDYAALIDGEPDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGH6</accession>
    <name>K1VGH6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase, C-terminal domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGH6"/>
    <dbReference type="STRING" id="1220162.K1VGH6"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_1_1_1"/>
    <dbReference type="InParanoid" id="K1VGH6"/>
    <dbReference type="OMA" id="FQGAMFM"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="203"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="317"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="614" mass="66304" checksum="067AFAF42730741F" modified="2012-11-28" version="1">MSKPQVSQPATSTTGFFQPTPVVQNQWEEDAALRRASALFVPPSVLSKVSSELSKLGAEVLTPEILAHVTNAEKNPPYIDGDGFNSFGVPKDSAALVTSPGWKALQDFGLENGVVATGYAKDLAGSARVVQVIKIHLWGASSAMVVCPSGMQDGATSVLIAELSRPPPSSLPKEMVDTRTKVFKKALSHLLDTNPKNAWTSGQWMTERRGGSDVSGTETFAKWVGLDDRTDADGLPLGPYSISGFKWFSSATDCGCALVLAWTEKGLSCFFAPTRVQGGAMNGIKIQRLKNKLGTKALPTAELEIKGMRAWLVGEEGRGVSVIATVLNVTRFHNAARGVGFLGRGLGIARAFSRVRTFPKTGAALKTIPLFNKTLAATTLRYRADTLLTFFLAALLGSVQAQAPNPLVPEGQDAELLLRILTSVAKAYTTKHGIHGLQECMEALGGVGYLENFETPEINVARIFRDANVFSIWEGTTDVLATDTVKCLTGRQGADVTAALDRWINTTLGGVKGFDEEKKEIKSQWEQFKNLPKEKEELLSLSRYVYHSLGDIVCAVLLLADAQRDGDAVAAECARRFVAGTLKGEKRQGGDWKEVSKWDHRIAFDGETQQSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGM2</accession>
    <name>K1VGM2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3beta-hydroxysteroid 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.270</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000261">
        <property type="protein sequence ID" value="EKD03260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGM2"/>
    <dbReference type="FunCoup" id="K1VGM2">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGM2"/>
    <dbReference type="eggNOG" id="KOG1478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029944_1_1_1"/>
    <dbReference type="InParanoid" id="K1VGM2"/>
    <dbReference type="OMA" id="WTGINWP"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="429" mass="46974" checksum="4EFE66D93BD19CBE" modified="2012-11-28" version="1">MVSTRSKSTIAVPADPNRIVAVVTGANSGFGLGICNALLSNLSVPSGSSIPVATAQVSALSPSLASSFDAGAASTASAMPRPHPFLTLVLACRSERNAKEARDKILAQHRKDLEARRRSCVPVPEGWEESLRVEYELVDLDAMGGDKGVMAFTRRMKERYPHITSLFLNAGYAAINEVNIPRFMWQVITDGPLQALHHPRYNIEDVGLLSADGERGRVWGVNVLAPYVLELQPLLAASPKELPFNPRVVYTSSIEAEADGLKAKPLDDPELLTYESSYRASKYMGDLVMTQLDRDLSPSGVRCLVAEPGCVSTNIAVSGLGAWQWLVKIKWACYWLSFWLANLFGSPHHPVWAEYGAAPMLYAALVASVYLLPATKVPGPKVHVVAKRWAQPGVGYGEVDEWEKNEDVAKGEAVYCEQVRQQWRRKEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGV0</accession>
    <name>K1VGV0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ste11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VGV0"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002076_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGV0"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="173"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="745"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1537"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="855"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1331"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1342"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1362"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1484"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1494"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1566"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1828" mass="198347" checksum="5733375DA3AB78BB" modified="2012-11-28" version="1">MSLLPEPSTDPPQHLHPLRRDLHRQQMEPPTTGYNQAWTPIGYVLGQFYHPPSHAIQVVPHPDREGPTTTGPVELDDVDEQGDGKPRECPLCRRPWSPVITPSARPSRTLGRGDSSYFRVLERAHGFSQPGTPIDAESNRDSTTPVEPSSTSGADDMIDINDLPAMGYYRRFFKEEARLGIGAEGSVYLATHVIGGNALVKKIAVGTSKTYLVRMLREVRLLEALRHPNIIPYYHSWVDETQFSSFSPPILALHVLMMYASAGNLDAFLINRSHAASVDTESAGGLALNDDFEHLPKAERIKAFKRRRQSGVGRVKGESRGVLLLGLEEVLKLFGDVVEGLAFLAPETIIMDVNGDWRPSDSHADMWSLGKGGHVFSAHSASDDLSALHEEIIRYRGFHPTPEVIEVCERRHIPRAMLLLLEKLLDLSPEQRPNAERVKLALSRFKSSSLGNKLGSLWKNKFKDKRRQEVSGEGNHADVEKRAADRSPVRSLLALPSPPGYPEVKVAPTEPAVEIEGIDWRRYAWLALFTLKPNVLGVQLPPAVVLCLVIIAVVDVPSDSTSLALSGGLLLIHISALVSAKLNAKKGQRSGSVAWRTRMGPEPQVSQSSISSRLGNSFLPVWSFLHPGHHHILRRKRHCSDRPPPHAITPHTPPVSTSQSTLFCHISVLGPSRPLFASRPANACAAVSSAATHQDDESSTTPTSEGFAMKSDADGAARNGQHRPTTPPLLKAPPGQTFGAHVRLWGDAEIASFLNMYKCDQYIELFNRNDIDGKVLLDLDMSSLKEIGISKIGDRVKLLGGVRDLRKRAARTPSSAILGARMLPTLVPAVDGSPVPTSDARSSQVQKRLATALFSKRLASSRPPPLNLQRPNPLPSTVDGSASGGSPNSRSVTPKSGPPKQISALTEAGSARPPLPPQEPSISLRPPAGREMRRSPSPVAGQTHSNPNSRGGVPSGDIPAQLVDDSWTNISAAAKSSDRRQGVHRFGDARADFMVSGKAISPTQPQIRDNVQPHPFANVIRKDDASSSENHKRGALPRNGMPANSTGEAIQHRTIPLEDLWRHLVKFVNSEDGTSRTVNVSNCTSGLAVLDLVLKKFGKGGSNWNPDSESGDSDRLEWDGWGVFTRKENGEEDQQLSESALLDICHDQRSVKLGGLDSTVVRERGLLIKRVSQQPNRKNMEIFFGEAPPPPGSPNSPSHYGVPRLGRQAEDRRDSATKPAANKQMNRASTVSIMSGLGVPGAVDASPSVNTSRASSTGNVSSRTKRMYNFFGHRPPSELISNHLSEYFPSARKRDLEKTVRQSMRLSQAPADRLGLGGALGAASPLSASLENVASPNRKARPPSTRTVSSSTTPAVIPEEVETAHPDVTGRNRASAEQDENGAPVGSHPPLLPPFESTGESLVDSLQEYSPAPTSVRPALRPGRRGSTGSTLSRISVISSVKRNKDKSDTASLLTVDEITAEVENRRASMATTDLFDTDPSLTSASSSVISVPDSDDDSSSSEASEDEEEDSATSDDDERDQGRALTSTGSRRMIKWIKGALIGQGSFGSVFLGMDAQSGLLMAVKQVELPSGDARNEEKKRNMVQALEREIELLKELQHENIVQYLDGNHLYIFLEYVPGGSVAALLNNYGAFEEALVRNFVRQILTGLNYLHERGIIHRDIKGANILVDNKGGIKISDFGISKKAENTNRPSLQGSVFWMAPEVVKQTIYTSKADIWSVGCLVVEMLTGTHPWAELDQMQAFFRIGSMARPATPSDISTDAAEFLQRTLEIDHDLRPTASALLEHTFITAQAAAVPGAVSIEQANATMDAVAAARRNPMPGLPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGX3</accession>
    <name>K1VGX3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000351">
        <property type="protein sequence ID" value="EKD00066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGX3"/>
    <dbReference type="eggNOG" id="ENOG502SPZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413994_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGX3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046528510" evidence="1">
        <location>
            <begin position="19"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="663" mass="73254" checksum="D7E51F9BCC805AB5" modified="2012-11-28" version="1">MKTTQAMLLLAFLGATAAEIPTFTFQGTTTFPRKMGADIAASQFVDETGTYRFISSVASYAQYDDGTSYTRTFTGNNFGHLSDKWGTDETSMVDYNSYWDKPGSMCYRLDEREVNPMPSLYQDDHCDVIGVWIDPATKEWYGGVNDEYQFDPWNHGEVTQNARIKTGRHNNRLLLARSGDQGKTWAVVDQIVTDPYQPNQTITPELFPNATYSWGLSGVRFYPDYISGYAYLLYNHQFRTKNGDKTLLGYFSMARTEMASGLTGWKKWYGGKWEEPGVGGRDGFIGEPLGFNVVYDPKTDYLAFEGKGADGSDVVYQNEIFTAASGFKFRDLDGTEYHVSTASKPHSITRDGSQVDKVTYLDPVVNRTILATIGVTGEMVFNATDADGASIGWVPTKGLNIFKSPEWRVYVPPKPLNQAGFTYHVPSSQYLANGYELPISATHDLGDPSSWRPVGKQTEDMLAHASYLSVLDTGSLTNQFVTGRTLSLISDLRVTEDRYTAPADNAYLPDFYPPDAEGKPLTEATYNVSIGDKALGRFTLEWVKDTYNGAYTGFFRLKGEKGYLKTDGSVADTRKWGAPLVTGAKGPDFDPKGNGGHGSPYGSDVWFLIPFTGERTSLDDTQGYKLAHRASHNVATNGASGAELQSNQRATNEATKVSFALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGZ1</accession>
    <name>K1VGZ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGZ1"/>
    <dbReference type="HOGENOM" id="CLU_2265587_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGZ1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="103" mass="11691" checksum="902265523BD412B1" modified="2012-11-28" version="1">MPPRNPAFRSVDPDTTPEVKNQYTQALIHNGIIYGSGTIPWNRERQIVGDNITDQARDFAAFEQVLREYFGEHKPARINLNNPQLPANSLVEIDFIAAVEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGZ8</accession>
    <name>K1VGZ8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000254">
        <property type="protein sequence ID" value="EKD03395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGZ8"/>
    <dbReference type="HOGENOM" id="CLU_1074379_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGZ8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852150" evidence="3">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="297" mass="32035" checksum="4E4C80553D4E0163" modified="2012-11-28" version="1">MKVSAIVLGAIATTASAAALPFGDGEWKFPNIRIGYAGAHHDYGNLDKRGMMPCHQAHGAVQRSNQPSGLGRLLAHLGFDSYTVSRYEHHHKHDDGHKGHHKDHKHEGHHHGDVAFQSEGSFAPPPQDAEMRILPIFGQKADEAYAEKHVAAQPAQRPHYHGHGHGHGHGYHHPHAAAHRALSAVLYKLDHAGEAVTAFIRSLRFDAAYLIIGYIVGGALGFVAARKIRQARARRNAIRLDDALAGAPVLAASLMCDMRKLSWRGGLDRARGAGAGRLSDGAKVVPVRAFVVNAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH60</accession>
    <name>K1VH60_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein YHM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000347">
        <property type="protein sequence ID" value="EKD00136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH60"/>
    <dbReference type="FunCoup" id="K1VH60">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH60"/>
    <dbReference type="eggNOG" id="KOG0750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053371_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH60"/>
    <dbReference type="OMA" id="GQPWFSD"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD00136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="299" mass="32137" checksum="94F399AA4B53D11B" modified="2012-11-28" version="1">MSPPGDFKRESGTARILGSGTSGIAELIVFHPVDTVAKRLMSNRGQVSASTLNQIIFKNAANAPVVTKFMSLFPGLGYAAGYKVAQRVYKFGGQPYFRDLIDKGAGDWFRDTFGKKTGSMLMQASAGSLTGIGEVVLLPLDVLKIKMQTNPEAIKGRGLVKLITEEGLGSLYRGWGWTMARNAPGSFALFGGSAATKEWLFHLNDYSQATWTQNFIASIAGAVSSITVAAPLDVVKTRIQNANFGQNVSGFTVIKDMVRSEGPGAFFKGLTPKILVVGPKLVFSYTLAQSLIPFFGKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH98</accession>
    <name>K1VH98_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_07183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000388">
        <property type="protein sequence ID" value="EKC98501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH98"/>
    <dbReference type="STRING" id="1220162.K1VH98"/>
    <dbReference type="eggNOG" id="KOG1118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448341_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH98"/>
    <dbReference type="OMA" id="FKPKGMC"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="514"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="574"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="694" mass="76175" checksum="A4E5E8D0B49438BE" modified="2012-11-28" version="1">MARGRGGCQVPRRASGPAQSRPEHDSVNPEIRPLPSLSPSTPAFQRPWCHRASPYEPGRTSGKLEIIQSKPPFTAFLDIASLISPPLPSPPAFVRPCSAKRSNRCAINSHAAADIQFNKVTQWTNEKVFSSTEKTKFSEEFEEFEAELEPLCIGVERLHTTSNAFYEDSVKLKANPDPYPSGENGKEKMRLSEALGLVMMDYGNDAGGALARCKLAEYQDEFSARLYEHYVMNTEKALNCVNEYRTYRKKMDSRRLTLDASLTRQRTSKRDNPAIEQEVELAQERLDEAADETKLRMQAIKEEQEMQFHALAALLDAELDYFTRCKSVLEDLLSEFPTSYEAPAASTSSRPVTRPRAKSSASASGRSAAATPKRKDSDEDETPKKERPEMNRARSDSASRKRISIMSSLGNIGNKGMKGGKAAASVASSAASKTASYRPSQRLFGRSEKKYANMDEEERRAVSLATDDEDSRYDPPARTSSPPKSRQRSHSVAAEILTTTNGAGRRRALTTPSTPGTFVKVLFDFEGLEADELPLRRGQIVEVRSEVSADWLIGEADGMTGLFPKAFTEEYIPDRPALPSRPGSFSHLRNHTHLGVPDSSNRSVRSDISGGESDSDSLDIIDDGQSTSLASAPAPTPTSRSRAGSVARKAPPPPPSRRASVMSPPRPPVPRSRSSTLSRPQEASPFGASPFSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHJ2</accession>
    <name>K1VHJ2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHJ2"/>
    <dbReference type="STRING" id="1220162.K1VHJ2"/>
    <dbReference type="eggNOG" id="ENOG502SJQ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367605_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHJ2"/>
    <dbReference type="OMA" id="ELVAWNW"/>
    <dbReference type="OrthoDB" id="2745718at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="699" mass="77995" checksum="9B080DAA6FC2F84A" modified="2012-11-28" version="1">MFDRLTMVLPTDKEEPSAVDSVLDRISMWGNSKPKWEPDGPCFLLGLPHEVLERILLLADNSSILNAIQTCRTLKAVSESPAVQYRLILERSGYIDCPNHPRPAQPTFSGVASSRARTSPHTGRLRPTIPSVTLADWPATPAETVDLSNLSAVDKAKLLRAREDRWDALDAAEVRTFQVSGHMNVYELQEGILLVCEIVRLIPLPSVTDPDLEDPIIPTKANKVDFQIADLTMDPTQDLIVVSELDPRPERPGQPAPAHKLHLLTLSTFEPHPLAARTVLDFPPVDVPAIMPRQLLQVLGDTLVVLVSREGANMLQQADDLLAVFGIDMEEELVAWNWKTGEVLARIHLGRSASECSFVMLTPTTVAIAMPAVVESLRPVRTAPPMIQIYSFAQRNPGQKVDQPLTFNRLDDTTPRAVPVAKLLIPALTDGAGLYTFHMRPDPAFPPQKDAPLASKPFTQDPGKGVIVCDLVIASATAPHTEFHPQFFDFFILREYLIQLAEEGEARRRVGWENNLSERAALRTIFWEDWGEANSRMLLKFMDPPRQLVRILHPELHSPSSLADIQVCSCSGYRYVSMLNSTGPSEYLNIVIQDFNPHTIARERARRRAEGKGTGWIQSDDGEYQVALWDRDEPTTIAPEPAWRDKVVTTLPFRAVQRPFKATGKKPKGVMMDAERVMLIASYDEEVGTIRQEITTLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIX5</accession>
    <name>K1VIX5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIX5"/>
    <dbReference type="HOGENOM" id="CLU_809385_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIX5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="343" mass="36471" checksum="6E758031D9791978" modified="2012-11-28" version="1">MAPPPPRRPAPPLPTMPTPTRPTHSTHPSEVKADTLPAFYNADALKSLNGTATVTRDPARRRAGAFQKFSPRTPRTQQPCSPRSPYSPRRTPRTPRRRCSAMATGSPQWYKTVGEASVERALGSMMHSLRLAASSPGREISRWSSSTDGSSSGGASSFASFFRGKTQSADSAPTADTSLASNSSTKPADAPNTDAASIKSVKSAHSSRSVRSFASFRSARSAKSVAAASTKSSRSRKWHWGHKNEGEEIPPIPAWHAADAEAAPAHHFAEGSEGSSGGYHPFKERPRKIVEGFLKRLTPRRSHEDGRGASYATLLTHSAIAGGIESSSICPNTGGTESTETGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIY3</accession>
    <name>K1VIY3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241218_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIY3"/>
    <dbReference type="OMA" id="GGRTETY"/>
    <dbReference type="OrthoDB" id="10691946at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="464"/>
            <end position="489"/>
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            <begin position="642"/>
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            <begin position="750"/>
            <end position="832"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
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        <location>
            <begin position="983"/>
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        </location>
    </feature>
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            <begin position="1199"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1799"/>
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            <begin position="1836"/>
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            <begin position="777"/>
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            <begin position="810"/>
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    </feature>
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        <location>
            <begin position="1505"/>
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    </feature>
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        <location>
            <begin position="1544"/>
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        <location>
            <begin position="1677"/>
            <end position="1711"/>
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    </feature>
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        <location>
            <begin position="1877"/>
            <end position="1888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1943" mass="209540" checksum="67442672C63ADA1F" modified="2012-11-28" version="1">MPDASLTFEYDLKHVNSACKGQDGGSGFGQRAHCAGYGLEGRRPGRTWARPAREAPNSAAKPTSRAAGEGSGLELLEQWAKTGPSANREWIQLDEGTLGVERKHFTISTLTHLTPWPGTALSRILPGLPSTAAHSTPTICSSAVQTPYAPAAEDSVTAIHDQPSARPPACVFGCDPYLTLPTSHLYPSFIFHLTQSTCTTFTRRPQPVCSIRLSCPPVPQRPQAVVRTRGSTRVARITGVVYPTRQSLCPSYSMVVVNKRLCLLLPACTLYQLRLLALSIPFSTFSTAHGADVALMTPHPRPPTPCDYGHSNQNATPIPIPDIIVAFPDSLEGPNYYGNYNDFYCGSEFTSTSTTLSSLTRLGSFRRLTRSSSSLGPKSGQRGRAYSTGATTGLGDFAEAARDAMAEKRRPWGRTGSFRTSGVDSRRAPPPPDDDELDGYVPYRPPYVSQPTPSTSQPIVIKPSGAQGIGLAPKRTPPKHGRPPISKKPSFFRKLLGTTRNDRSKLISASTPSLSLQEKGDRPHYHQHQHQHYHYQRHGRQPSQSSTQFYQANTFNGRHYQTRRHDARNIPSVGTGLSGPSVLFSPLTRNSSVRHSVRNGSTGGSNVSNLNVALLGDSSNMNIQPSTNHHLYASTPNLIDMSEKQSQPAHDWRHTREHRRPGASISHSQAPTTPPTRRRSLRRGDSTLSLHSEGSRSRLAVSTMCDALTFPRPRMYAHEVTPPDSPTDDEALSTQATANINEFKQAMHATVSRNTEREDWAAITRRPSGSSMHRKSSSWSRGSDCSHSQPSIINGPPSAFTTPRKHNRTPSRERSRDRSERDYGERIYPQRTNSVAGSLRSFFIGSSSNAHSEDDLLGGGGRRSRPSSRMSYSDTEQSSNLHSGPVRPGSASSGHSLTIIGSSRGLPKSTSTPSLVPHKTPKSTGHTPRRSKSHRHSRRHSRNDSGPQYVPPPPVIRHAGPPRAFQFHLQSAARAHTGVVTIGGTSQERTTRHFRPPPPPPVSARPVDFAQARLRRPQSTEPPVQRRNRPRRLSSPVNLDRPPVQMVSIKAAPDEEIGVAITTDRDQPLRSPVRRRLDADDDSASAHARYLAARQQRQNASLPSLLSDGPVTPTADRQVLPPAKSQTGSGPFQFQSSTSSVVPVSPKEPRRSLERKDRFLSTSDVPPVPSLQASWYAAHARSPSTPPLSTQSVVNIPAETEVGPSSPMKVAGKGSERGSILSEKPIHTLSTPTASSSYPESPTESSVLQSLDSPTISPFADVHRAPASAPARIPPRRAPPTHPPPPAPIFAPSHSRNNSQSRSGSSWKFNAPSVSSGSQHSQNVVTPARSKAMTANMTPLGFLAASSPPKSTRELTPEDQEPAMEESPEGTQPRSDTPPPKQRETLMDESPTPIRTFRVQALAPPRPSPSAAASFAAQQAATPVSSSLPAAQPSSPMVPLSPTTPLGNRLNMGSTTSLVPGPAMPDSLPDSSPLIGQVSPVSVSQPLASPAPETPTFGAERSRSNDSISTTTSVAMPSLSGRTPESAERPPAAAAAILKRRGQGSLSIQTSPSTDRIRQDHRHLSVTRSLTPDSIARSIAASEMSETTLPDLFPPPEESEASHYSSAMEDSGSVDTHDPAPEEFFTPTIEEQQPMFPDFRLSSIELALEPFPEPPTPAERDRPLPPLPALGTRSVLGISNATPGPSRPSTARAQSSGAVTTLSQKSSNQSIRFAASVKQQEEKRSVSGPREVLENLLHTPRALSRRSSGHSTAHSTAFEYDKRSSLASLSSGSEGSMRPSLDGDFNGLFFRAPPVPAPLGHPFNRNSQHSQKRLSASSSASGSVIAPLASVKRTPVIEQLNEPRSAITDSPFVGGSEGTPELRTPLTGDPHFGRTLPTPPHPPSPRASPPRVTLDMSVLESPPRTTSYEPRGEIDISASPVPAPARQLDEHSWITECYPSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJG4</accession>
    <name>K1VJG4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase (NADPH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJG4"/>
    <dbReference type="FunCoup" id="K1VJG4">
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    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJG4"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_2_2_1"/>
    <dbReference type="InParanoid" id="K1VJG4"/>
    <dbReference type="OMA" id="AWKEEFY"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="309"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="594" mass="67233" checksum="9B8E28F864912C17" modified="2012-11-28" version="1">MKITDKLAKAEREGRPFWSFEYFPPRTAQGLQNLYDRIERMRNLGPEFIDITWGAGGKNADLTSSLVQVCQETIGIETCMHLTCTEMPKEKVEWALAQAKQFGCQNILALRGDPPAGSSTWKPTPGGFVHAVDLVKYIHKEYPGDFCVAVAGFPDGHPETPPTPEGHHQEMLWLKEKVDAGADFIFTQMFYDVDILFNWVKEVRSYGITVPIVPGIMPIQNWQKFQTWVQRENIKVPEHWYEALNPVKGDDEQVRAVGTKLVGEMCRAILANEECGIKGLHVYTLNLEKGARMLLEELGMNPNREQVAPLPWRPSLAANRRQESIRPIFWANRVESYLSRTSDWDEFPNGRWGDSRSPAYGDLDGYPVAINVQPADAENLWGQPKSEADVRELFARFCRGELKKLPWSSQPPASETSIISENLIKMNERGYLTINSQPAVDGAPSDDKVHGWGPAGGYVYQKAYLEFFVRPELLSQLIKRIERDPRITYYAVNKQGDLRTNTHSEGPNAVTWGVFPGKEIVQPTIVEAVSFIAWKDEAFELGNQWANLYPEGSESNKLIHKIMDESYLVNIVANDFKDGLAIFEPFLLDQPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJJ0</accession>
    <name>K1VJJ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger protein 830</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJJ0"/>
    <dbReference type="STRING" id="1220162.K1VJJ0"/>
    <dbReference type="eggNOG" id="ENOG502S9DW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041821_1_0_1"/>
    <dbReference type="InParanoid" id="K1VJJ0"/>
    <dbReference type="OMA" id="WDSHVRG"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29962" checksum="F0024680FCF62549" modified="2012-11-28" version="1">MDAKALLRAQKAAAKVQHPYASYNASGQLRCIVCAVPADRKVKQWDAHLLTKQHRQSVQRERAEEAKRAAAAAKRKQAAEPEPETAKRQRVTEPEPEEEEDDRPSLPPGFFSSGNGPSVAEDDEQESSAPPPKEEKKGDAELDAFLASLNDVDDAPAPTAAEQGETAKTKATKKRRVGYKESEEDGVASISAAPVLIQRNEAGEEKEPTPEPEETEQERRERLAREEKEEIIARLEEEQRAQEDADNRVLALKARMEALKKKREAKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK04</accession>
    <name>K1VK04_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000370">
        <property type="protein sequence ID" value="EKC99516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK04"/>
    <dbReference type="eggNOG" id="ENOG502RB74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_742246_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK04"/>
    <dbReference type="OrthoDB" id="2591812at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="373" mass="40287" checksum="E3D1FF01FF24D19E" modified="2012-11-28" version="1">MSTEYLLGGSPTSGVPAVTSFSADDGWHTMTNAEPTPTPSRRPLNSGIGADSKTIYLVFLAVLVLIVILAILLTIRRYRLRRRYWTATQLAISRGEPLPPARWGDDDPWGLLFPRPERWQGRRKERRWMRVPTLWDAVDTDGEIWEATGQSRLPPPPKPEPVLPAPVPPPQGLHAVGDAIRRGWRGAEPPPPPPPKVKEPKESDRPLEAEEPVRIAVLIQMPVDPSAPAPLYDDAEDEVAWRPGMELGVWEGNLAGSTNGMRAHEAEHVWAYPPVGYGDGGLESEPPASRPGRAGRGPAQAQAAQYASPSGPPPGLYSGHGAGGFDDRQPQTYSSSSAGIYGGYGSGGLESEQGMYAPPPGPPPTTYPPQRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKT6</accession>
    <name>K1VKT6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vacuolar protein sorting-associated protein vps5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_08300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKT6"/>
    <dbReference type="STRING" id="1220162.K1VKT6"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323137_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKT6"/>
    <dbReference type="OMA" id="WANPFAD"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="510"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC97377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="892" mass="96196" checksum="ABBB0602AA986929" modified="2012-11-28" version="1">MDEEENFARLPLRSTPAPKPKWGASEDSVAADPWANPFADADAGSGWGEPGISSFQPSTSTSSAPAPESPEQSVHDLPPDPPSVIAARERAELEGAGGFGSGGFGGGFDEDPYAPSPFGTPAARSPTKSPEPPTKTSPVVSQKHIPAGLMEYDPLTTTMDEEENFARLLSASTPAPKPKWGASEDSVAADPWANPFADADAGSGWGEPGISSFQPSTSTSSAPAPESPEQSVHDLPPDPPSVIAARERAELEGAGGFGSGGFGGGFDEDPYAPSPFGTPAARSPTKSPEPPTKTSPVVSQKHIPAGLIDEELLNESDPSVSLKKAFVKHNAPAGTSSAPATPDKKYVFKPKDKPVLPALPPAKKDVNPASIPLPESIAGTPTTSRPETPTLSTDRVNISPLETPTGETEKDFGFQSLAIGSSGMNGSSSPTAGRFGGRGWGAIEADDTPLTGSGDPWNEGGSGGWNNDSAAKEESDDDSEDNAPLRSSERAGSGDSTSSPDRRQKRLNTPMFQITVSDPTKVGDPVRGHVVYTVKTKTTSPHYRRGEFSVLRRYSDFLWLFEQLCANNPGVIVPPIPDKHPFGRFQDQFIETRRAALQRALGKMTSHPILQLDPDLRLFLESESFAMDIKNRRSQTPESTSSSGLLGSWTGPKYVEQDDWFDQRKAYLDHLETQLKGISKSLDIASKARLDMADSLGVFSDSTFALSESDLGAAMCTAFKKLSDLVRREKEMNENQAKDDVSKLLNLSDEYIRFIQSVRLAFASRVKAYHYWQSCEKEVNKVRSAREKQRLAGRAGGSGHEVGEAERRARDAAAEFEAQSKLVKAEFARFERERVDEFRTTLSNHLDDQIRRQRDITTAWEDYHAMLLKMVQRAQAQQQAQAEAQARAQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKZ1</accession>
    <name>K1VKZ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-nitrophenylphosphatase</fullName>
            <ecNumber evidence="3">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_00889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKZ1"/>
    <dbReference type="FunCoup" id="K1VKZ1">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKZ1"/>
    <dbReference type="eggNOG" id="KOG2882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKZ1"/>
    <dbReference type="OMA" id="PPMHRET"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD04835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="38919" checksum="832D2B20A15A29CC" modified="2012-11-28" version="1">MSATPSAAPSVPASAIPSQRTSPAPRHPEHVPQFPPGTDIDQLDPPFLHTKEQYQKLWDSVDTLLLDCDGVIYHGPIVVPGVKTVLQLARKQGKQIIFVTNNGTKSRRMYKKTFDKLGIEAHESEIFGSGYASAVYLSKVLKFPQDKCVYLLGEKGLEEELDSVGIKHKGGTDPADNVVLTSPPDFSSFEKDPSVGAVLCSMDFGINYKKLSKAYSYLRDNPGCEFLLTNQDKVYPTGGTTWVGKLSLARRELTPGSGSLSSPLVFALQGKKEPTVVGKPNKPMMDAIIAEHHFDKSRALMVGDNQLTDIAFGNNSGIRTLLVLGGVTHEDQVWGPKASDIKPTYVMNSLGDFATLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL20</accession>
    <name>K1VL20_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="2">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL20"/>
    <dbReference type="STRING" id="1220162.K1VL20"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_2_2_1"/>
    <dbReference type="InParanoid" id="K1VL20"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="84" mass="9427" checksum="21C79017D3C7C413" modified="2012-11-28" version="1">MLYVIGLGLSDEKDITVKGLEKCERVYLEAYTSILMVEKEKLEEFYGRPVITATRETVELESDDILKDADKVDVAFLVVGDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL38</accession>
    <name>K1VL38_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Peroxisome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_00841</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL38"/>
    <dbReference type="STRING" id="1220162.K1VL38"/>
    <dbReference type="eggNOG" id="KOG2879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024591_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL38"/>
    <dbReference type="OMA" id="CQPWNGD"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="50"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD04895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="406" mass="44958" checksum="0066F35C84AC4D67" modified="2012-11-28" version="1">MGEASVSRRQRAYEPRAPLVNQVDADELDDGVVEMLVDGVEKAVCRFKPNIDIKPELTLLLKLLVLGAGVLGPSNASPGAAMQNLRLISSRGPTRPTRRTLLLYLLLHPPLFPAYILQRVRQTALSRQWPDLPAHDWRRRAWRLLTRLETLARAWELAGWTLFLWDGAAPSLLMRILHLRFAPTAPRLARMVSYEFMNRQLVWGVMTEFLMFAVPRIPSLPPALNPATAFAPVRQFLSQPTQIDYAALSASAGELSAARKAGTAAPSSAHSGPFARLPASVCPVCYVRRTEQPQALSGTDIELPSLDNAETEDEDKIFVPAQTDCWGQCMYCYYCVADELARAGKRAEKGEQEKPVWPCLRCGGDVTRAWRATAQETGFIPPTPESSDSDSTPTSEKMGDSYVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL81</accession>
    <name>K1VL81_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL81"/>
    <dbReference type="HOGENOM" id="CLU_628800_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL81"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="436" mass="47884" checksum="FB2AA10A0EEB9E82" modified="2012-11-28" version="1">MHEAIEPGHWSARSVSNARHALLSGLKGGFRSALRDCAPLVLSEVRVPARIRHDCVYETLQPCQGSQSLGSLCAIYHPITGFKIIASSHDGILGAQCSSDALPKRVGLYGSVPPPTFVTGQYATASMFANDRSGPLTAQRDTPPAHECELCRAHEKSTAAGFVHLHYPRDHDCVSAAYGDDGTTYLLYREDRATVTRLQQTGRPLAIPKKLYRKHKLLSQALDGALQDAFREAGLKPPPCIAVPTAEPPTTTDEDSAAGAHCPAAGATEAQVAPHSTEEARDVQRAGELLEHVSIASDQASASQLALSRKPLGRYPVFRGELCDRCCLDTGSWVHVHLPSYGLCWTFRWVRGLRRELSRLGTDPGTAQTEITTEQAINLRKAVERNVRIRLESFYAEWDFAEMATDPEKRDKIWKRQGVDLEQWEQTKQRGDGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMJ7</accession>
    <name>K1VMJ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMJ7"/>
    <dbReference type="FunCoup" id="K1VMJ7">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMJ7"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001514_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMJ7"/>
    <dbReference type="OMA" id="LSWRKYA"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="589"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="853" mass="95069" checksum="BABD78E419E65AFC" modified="2012-11-28" version="1">MPSRADLAQQGFTVTSAKATNGETVHINDLTPRITVQRCAHPRVSPAEHSAEEGLASPLERAARPPLVVLPSERLPPHVKEVLLSRYEYLLTEKEMVADLLDAYRTCCVCEQWAASQDTVRCEVCKQFYHMSCLNPPLLAKPAKGYSWACLACTIQRRKDVESEKYRFVSNGGSAPPRTKAQSRKEKAAAAAANEKIFDKPDVMFRGWPWSLHTRAEDTLDAEDLIYPRAVTRVGTKFQANVMTWEEQQRAEEKRQSSLLDTGSSRLILERGYDPGEQNHDPTLMVLSEPSDDLADYMEEVRRMKMPVPPYDVRRLNAAVEAYTAYGRDDAIRYLKSLKLADFNPMVWSDEETRLLEAEFAKWNGLQASAASKVLGKRPAEVVRYTYMWKNKKYKAENELLRQHRKVHSIHGRTSSTLGPIPLGHVRRADSEMPDDDASSLYNANYVRDHKLQCAVCWTRISNVWWKCPRSVTGNAMCETCGSNYRKYGVLSAPKAEDAKRDYRKEPKSRRGAKADSASGTSTPVPQGPPKLPPCSLCRRMEPKASMARCKTCTFSAHAGCYGIKPEDLGAEWECELCANVTNEENNLDIKCMLCPRDQASVALKLAPKNKKPPADFDVLSALKPTEGCRWAHIICASWTPEVQFSDGTTLKDVEGISAIHDASWEAICTLCGQADGAKIPCTSGCGAVYHVSCAYMAGYKLGFFFSPVKAGKRDVTATITTFKDDAGIMSPGVWCKGHEPPPTTATTDMFELDPEQGECALNVYNKTYKAIPSDELFPLLRKAKRLDRFEPTVDEVKIELSEDKDVVMTTAKTCAVCGVDVSPRWHESTAGLECHKCWYANKPETRPVAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMY0</accession>
    <name>K1VMY0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuole protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMY0"/>
    <dbReference type="FunCoup" id="K1VMY0">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMY0"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMY0"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="276" mass="30374" checksum="F485BADD6B794857" modified="2012-11-28" version="1">MSSALPPDQEPLLGASSSKKGAARQSEDLVIGSSSAARNAWMDQPPDDDIPDDFKVGVTVADCDEAIRRAFLRKVYAILLCQVGLTALTAAVLMIPEAADFIHQHSWIIWTAMIGTFVSLGLTYWKRHSFPANMFCLALFTLCESIMIGSAVSYYDTFVVLQALLITSGVFVGLTLFTFQTKYDFSSFGPFLFAGLWGLITAGFVGFFLPFSHGFDIAIACAGVLIFSGYILYDTQQIMKRLSVDEAILGSLTLYLDFINLFLYVLRLLNSQNDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN52</accession>
    <name>K1VN52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN52"/>
    <dbReference type="STRING" id="1220162.K1VN52"/>
    <dbReference type="HOGENOM" id="CLU_671189_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN52"/>
    <dbReference type="OrthoDB" id="3943625at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="157"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="500" mass="53730" checksum="9C5F009182ECD969" modified="2012-11-28" version="1">MNHPNVPVEVTYPIGPNTGTVKDFIDSGKIPVWNGTRDLLNGQLPANLGDASTSKAGATGQFGPEQGTNSNAAVFRYHGSVVARQYNPDLQLNLSIGAADYEGRKLDLTAQPDLPLPNPDRQLRCEYAYEHVLGGNGTTPKGALWALEGYVDLVAADVRQGGIGDCGMGAAVQAFAAGGWTRYLTRMFLKRFDTPNAGDRNIVAVFRRDGKVQPVLIDDQLPTLRNANPNCWQYPGFQPVNDAAYPDVTKPTPIFFMPLFEKVSPASAASGLRGEPFTPTVRATLTPQAFAKFLDANADWKSATGYTGYAGLEGVNPSYVLAAITGGNPSWVWRQRPGFDGPIIAAIARCMQGTAPCVVSTTNAQLEGLGTKDSTGALWLAPNQQPAYIPGETSGLTATDTNGVTFTVIDFDNLKDGKSSVFSWVSGHAYAFAWTRGTRWPIQDLLSPRIKFLNPWGVNPESWPGSNGKGQWDDPAELTSSFRTFLESVSGVFTVTDMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNB0</accession>
    <name>K1VNB0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNB0"/>
    <dbReference type="HOGENOM" id="CLU_1662044_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNB0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="16862" checksum="2430252814D572A3" modified="2012-11-28" version="1">MNVCPPSVDPWNSPELSSSATVQCDHYPGQALHTDAAHDYPRRPCEQAAGKRVSPWTRAAISISVSDRLRAPTAVRSTYRARCGHAAIIVGPGLPNSDSSAASVRGPPSAIDRHSPPYPHPQAPPFVPSVLALLRTAPPILLPGATPQVWTGSTPLAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP64</accession>
    <name>K1VP64_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP64"/>
    <dbReference type="FunCoup" id="K1VP64">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VP64"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_2_1_1"/>
    <dbReference type="InParanoid" id="K1VP64"/>
    <dbReference type="OMA" id="HEYETTH"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="320" mass="35531" checksum="12E08FB7CBED637F" modified="2012-11-28" version="1">MDTGEETYVRSALYNADATRAPNSTIKNDLEEVAQRWSQRGFDIWEELEGRHFYTDFVSWRSLQAGSHFARRMEDHGAADWYAGKSAEVAAVLTSYWNDKLQAYVSSDAQALAGAKRDGLDAQVLLAFVHAGDSGARGAWSPASPRVLSTLRAYVKSFKGLYKINPDASWTDGRLVGRYREDIYDGVGTSRANPWFICTHAVSTVLYLAAAQLSVADSIVVTRESRAFWSDITGTEVPEGTEWEKGEPEFDTALRNVHRVADRFAETAATFYDSGHMAEQIQKDTGKQTGARDLTWSYASFIEQERAKEAALNATPSILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPF9</accession>
    <name>K1VPF9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPF9"/>
    <dbReference type="MEROPS" id="S10.006"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="InParanoid" id="K1VPF9"/>
    <dbReference type="OMA" id="FDIGEMY"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006526913" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="606" mass="66677" checksum="53D0085F3E1007A3" modified="2012-11-28" version="1">MYKALGLLALAAPGLASMRDYIPAKYLKQPHLDIIHARDLQERHNDGHHDGGDKGNSSVGSRFLNDQTKPFHVPSLPDINVDLVEMYSGLIPIDTNNKTDGELFFVFQPKTSGDPVDEVTIWFNGGPGCSSLEAWFQENGHFQWLPGTKEATLNNFAWSNLTNMLYVEQPKGVGFSTGPLGFYTNEEDVAQDFIKFFKNWQDTFGIKNYKIYVTGESYAGRYVPYVSAAMLDANNTEYYDLKGALIYDPCIGQHDVIQQQLPAAQHIRDNNNIWGFNQTFLELIDKLDKQCHFSEYIDKYLTFPPAGVQPQLSYNSSNGGTNGLEQTLDPDYGCLIFDLALQEENRINPCFNLYEIIDHCPLPYDPIGSIATGGGKDEIYFNRKDVQEALHVQPKEWTQCVSPQPFHAGKRGGPEGEGDFSANPIEKVLPQVIDATKRVLISNGNYDFVIITNGTLLSIQNMTWGGQLGFQEKPSKDLVVTTPALNEAATIDDLTYSTPSTQGLYHEERGLMWVETFYAGHMQPQYQGRAAYMHMEWLLGHRDDLSARNSDLPIRKPKKGDGDGGDGSDGGDGGDGGDGGDGGDGGDGGDGGDGGDSQGNNTSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ54</accession>
    <name>K1VQ54_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Co-chaperone HscB C-terminal oligomerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ54"/>
    <dbReference type="STRING" id="1220162.K1VQ54"/>
    <dbReference type="HOGENOM" id="CLU_534405_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ54"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="4">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="510" mass="56638" checksum="682492EEA72738D0" modified="2012-11-28" version="1">MATDETDKVDNHDLLMEILEARETLEEADGQEVEELRQDNQAKVDDIVHQICELLHSKEPDLHAVKRLAVELRYGGEQWHLEPEKHPKQPTVPTVPDASHNVPPLRHTPPLSHVAAPSPQRLRFQLTIVHHHLDVSNLYSIHSSPAVLLTFFIDCSQDETHCRCQCGPFLTPQAPIDEDGFVVVSDDNSEENFSTPDNGPATPATPSPLSRQDIAEVFASSFTQLIRDSEVKAASQTAAVVASAVAKVRAELQRDIEALHATQVSLSLSLESVEIKAQQAERRAAEAEAQLEEMKDNCLCNGGNLSKTVCHLERRLDVTTNHCYDLERRMNSGDSLTVVQRNVNAVNLQTHKEETNKRLTALETRTKALEGTCETLEKRTAPPRFSSLPVAPTVQPIQPLSGFQGGADIALHRVEQRLNDDLRRKQEKLDSLSAQLKTERACSDSMFVKVAAMSLVLRGGPLPTEDGKVLQKVSSWLDRFKAKTSDPRLRERADGYITKINEKMVGTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQK3</accession>
    <name>K1VQK3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Microtubule motor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_02752</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000273">
        <property type="protein sequence ID" value="EKD02921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VQK3">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQK3"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_33_2_1"/>
    <dbReference type="InParanoid" id="K1VQK3"/>
    <dbReference type="OMA" id="PFDMVFG"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="61"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="991"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1034"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1104"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1135"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1205"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="429"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1104"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1205"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1240"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1258"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD02921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1318" mass="142421" checksum="D40E1A091AFA6112" modified="2012-11-28" version="1">MSRRQPIGRTASRPASLASGSRIARTQSSMMPPGTPRRATTTGLSAGPNAVKLSSEVSETNIHVVVRCRGRSQKEIDEATPVITTTGGPLSKNITVETTPVAAAAAASTFTTASSYNNGSGNTKTYPFDKVFGPEADQTMIFKEVAENMLDEVLAGYNCTMFAYGQTGDVDPTPLMEPSTEAGIIPRVLHRLFALLDAPENPEYAVRASYVELYNEELRDLLAPEYKDYTGGSQIRIFDDPANKKGVMIQGLEEAAVLDVKGGLALLNKGTQRRQTAETKMNSVSSRSHSIFTLTVQVKETSADKGEDLIRIGKFNLVDLAGSEAIGRSGAENKRAREAGMINQSLLTLGRVISALVDKSHHVPYRESKLTRLLQDSLGGKTKTCIIATVSPTRSNMEETLSTLDYALRAKSIKNRPEVNSQMTKAGLLKEYLTEIERLKADLFATREKNGIWMDPDNYKELQQSQQRQKSDYDEARQRVTAIEVELKTRKAEFERLTDRFVKTDSELKVARDAEQQLNGLLEKAKVDVDKAISDLAQERVVSEAYQRGEERLNAVAGELRSVAVDSVHDVDGLHDKVERMASVLDGNSETSSRFGTDMRSLFHVLQSDLSQLHSVQTEFGNTIRSDMQNYAQRGQQRHLADLDSSFKSFEQLVSTLQGSTEEGAAQATDRAAAILAVKAEVLSAVRAQAEAETERFTKMGEELLMQQQKHLSSVSNVINSTADVVEAVLSAARTLKTAQNETLQAAKQQSNSAAEAEIARLRQQNQQLTQLLIDKDAETAKLRENLIAGVTDLITGATDAQNTSLRSAIGKIQAGNDAGLREVQAFKVSQSAAIDKGAASMETFSRQIATQKDAFQGQRDNGQRAIADAERGLQASLEEYASEASEQARIHVESIEDFCGLITEQAEGIETSVTEKAQEQADTIASLQSNGQASFQLSSSRVRAGADDIATLTSTLLDSHATSSEASAQAHSSAKRKIDEITDATDAFLSNLRQDEPTGSTPRKKQWAIPSWERTGPREMLLRGFRSAPPVIASPLKRSFSGDDDADVSHTSADARLSPQAAAPADTIASLQSNGQASFQLSSSRVRAGADDIATLTSTLLDSHATSSEASAQAHSSAKRKIDEITDATDAFLSNLRQDEPTGSTPRKKQWAIPSWERTGPREMLLRGFRSAPPVIASPLKRSFSGDDDADVSHTSAVSVGSAVSAASGTSAISAASGRSAQSSGSRPRSPADPPAPPRELKESKVSRPELRPAASLPPLSRTTSSSSTAVEDRGPLVNSMNGKRPKNKRIDSTSSDIPRVNVLGEGGNIPRKQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRP6</accession>
    <name>K1VRP6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03494</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRP6"/>
    <dbReference type="STRING" id="1220162.K1VRP6"/>
    <dbReference type="eggNOG" id="KOG0155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013872_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRP6"/>
    <dbReference type="OMA" id="GMWLQPP"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000502">
        <property type="entry name" value="Actin-Related Proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000044">
        <property type="entry name" value="Transcription elongation regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="10">
        <location>
            <begin position="605"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="663"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="938" mass="107992" checksum="43E04CFF729CB4B3" modified="2012-11-28" version="1">MAGGLEDKLFIGKRAQEYRGLLKIQYPMEHGVVTDWDDMERIWGWVYNEGLKALSEEIFFETFNVPAFFTSVQAILSLCVRKIGAQLTSRYSTGRTTGIVLDSGDGVTHAVPVYEGFSMPHAIQRIDLAGRDVTDHLQLLLRKAGHYLHTSAEKEVVRTIKEKTCYLSLNPSKEEKDHAGAWEEFRLPDGKVIQLGTERFLAPEILFNPELVGQEYPGVHQVIVDSINRCDMDLRKSLFSNIVLSGGSTLCTAPDGKTPYYYNAATKTSTYRRPVLVVPAAPIPPPAAPAAPPTEKKRKKEKAKVKTPIPGTSWTRVTTNEGHTFYFEKETKRSEWTVPPEIAEAVAAFDEAERREKEEKEKAERLERIREQERIRAEVAEERKRKAEEKKRKAADQGEGAPEPKAQKQDKEKDDEVEEQYAPEGEDEEAWMKAVAAEFAEADKKAAADAEDAEAAQKKAEEEAAKKVFAAKSEVKVSLEEGRALFKEISPFAPWDVSLPFFVNDPRYVLLPSEKERREAYEDYCRDAGRARRLNKPKPAVEKKADPEREYRALLREQVTSTRTRWDDFRRRYRKEKAFYSYGRDDREREKLFKTHLRELGERKRADAQRAEADFMELLKESDDIKPGAPWSQAKQGIKNDPRYDAVGSSSLREELFNKYIKTLGETEPESTETAAERKIRERKERQQASLREREQSVREQQAKMSEEVDKSRKDAGREEGERMFSSLLTDAIRDAMTWEEAKAILQQDRRFAHPALRMGDKQRLFEGHVARLGGKRDNALHALFAQHAQLDTPFDTVYPLVIEDPVVTRLGLDARALEERYDQWIQSREEKARAEFIELLGENSFVDFWGRMRNKEIDADASKIKDEEMADDEEGKDKNMVDLAQKIDLGEIKSILRRDRRYRQFDHMPEEREQWLRDYLENLEGSKGSETVHNVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRQ6</accession>
    <name>K1VRQ6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic amino acid family biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRQ6"/>
    <dbReference type="STRING" id="1220162.K1VRQ6"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1961133_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRQ6"/>
    <dbReference type="OMA" id="KELQAPC"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF1">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="128" mass="13706" checksum="B56C42C6E40DE238" modified="2012-11-28" version="1">MSDLADVLKISILGNESIHAGFHLVDYIFHTVLTTLPSTTYALITDTNLAKLYLPQLEEAFAKAAKDTGSKARFLVHQVAPGEGAKSRAVKAEIEDWLLSEKCTRDTVILAFGGGVIGDLTGFVAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRS3</accession>
    <name>K1VRS3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRS3"/>
    <dbReference type="STRING" id="1220162.K1VRS3"/>
    <dbReference type="HOGENOM" id="CLU_2160183_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRS3"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="111" mass="12158" checksum="83F5F1CB6534422E" modified="2012-11-28" version="1">MPRLQAQDAPYTPSEAPEDVIIVRLGAPTGSNNFNSTGADGVERLVELPAKIRKMTLASRGMFAPSTLDTQQQPQQRAGDSDELPENPNRRRQVETDSEADSSEEESSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRT7</accession>
    <name>K1VRT7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRT7"/>
    <dbReference type="HOGENOM" id="CLU_427104_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRT7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71310" checksum="C97B5044351A213F" modified="2012-11-28" version="1">MAPKRKSDPDRRSDGRKKRSADKVSTTSETPATASDGKLAYNEFPHILESVIRFAPRDSLVQLRRVSKHVKKLAEAELCRHLVIYPDYGIVMTTRRGTMVNVGVGTLEEGGRVQANPTFNAWYNDYIDTYRPMPDFSENFLLGEDEDDEFDDDDESDDDDDDDDEEDDDQEPDEPDFDSDDGDPNGYDIDEENVLDLGAALFPQGHPPGNGGNEVSDDDSELSFSSEGEQEEAMALMQMLVQQNQILGNESIVPPTNANGGPIGHAGELLAAAIAAANGNGGAGDSDSGGSSEGEGGWETFSDEDDDDGDTEDEDDGLSDGESDLMDDFLGRPGGAFADTGDEYSSEEEMGIEEFSHRLPEQAAIAMKNAEVVDIFQRPPYRGIIRLMRATNKVHSVRYHLPYAQPHSMVKCFYASNAPRVVQFSLLAPIKQYDLFDEGNPGSALGRSTRFVDSTKLRRGCKKAVFNVAYDVGCKGLRNGRIRFDDYPDTVEEVVLILTKTAWDMKPTAKGNRRDARPYDGKGWFEEFVLTEASKPTHKLTIVGLQDVPPGALSLKRDATPAEKIARFDYRMHEAKRLLTDDNFTRQIYWEMEGPSENWDAEFKKYMDDLEYLTHDEYKARLGAAEWSIENEILPGVRHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT82</accession>
    <name>K1VT82_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT82"/>
    <dbReference type="STRING" id="1220162.K1VT82"/>
    <dbReference type="eggNOG" id="ENOG502SG8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1316228_0_0_1"/>
    <dbReference type="InParanoid" id="K1VT82"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="209" mass="22991" checksum="9607BB624A3CCFBB" modified="2012-11-28" version="1">MSSPSLHYLLSSLRSPIFNTAAVTSNARTGAKYLKRRLRADNALLYAVQSPTMRVFANDKNFRGWEGLARPGDDGYDTQLPIDMVVPPSTANVEFVEVPRAARPGPSNITKYRSHWIEDANEYVRFDVLDGKRANGKTAPKKGEFADGSEGAVTRRGSGRRRGKADSAAPRGIFHVPESYLCSLQLQKPLCRANITGEGKRVLAGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTY1</accession>
    <name>K1VTY1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTY1"/>
    <dbReference type="HOGENOM" id="CLU_434897_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTY1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="629" mass="70230" checksum="3F7EDFD0DADFDCB2" modified="2012-11-28" version="1">MGTTIDYASFPHTQHDALTLPPADPKDGSLIVGSTAFDIPVLRAPESKSDDETLPLTAGIDRAQEFAIRQARTVSIWSTDFMWDNICASKYGPDYTSPFTMVTASRLHFYLFDINISGQDHNEWLPIKFPPTVRELLIHIVNESSLDGVEVTHSCTALTLLMEVGCGRRLEYDRIGSFIIDVVTPDVKELLILPDRLSDVLIYLKAIQNCKTHPQLRIVIAPCYLLPRETAHALRQIVAGMVNAEVVVLPRRCNAVHWSMEPRLLCDLGSTQGCACFRPDGSLLLLPHLSPWLLVSIHLSFTTPSPTQSVHFDPDITAIEFGPGMVSTLDYAFFPHLFSLVVEHCDFETQLRLRLLSSTAKLEVDKQLCRQIHVYIFPTEYEEDHPPDLESPQCLPEEASFSITIEGGEARLRAPILWSAGSGPEMEVSDMTTAIRPAFVFALRNAHIVTTRSECLLWDHTSATNAAQGGTSYHSPFEVLNPSHMNLYVDEFLWLGGEFMGPNPVPLPASVRHLFVHFCDCGPAADSWLAHKCTTVTVRLELYYPLKEEDACTLMRELITPCVRDFLVVVDDMNDAVAYLNVLKKTDRHSLLAITVETTSKVDPYDPDELQARLNKAAQTEVVVRPHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU03</accession>
    <name>K1VU03_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic initiation factor 4F subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU03"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002459_2_1_1"/>
    <dbReference type="InParanoid" id="K1VU03"/>
    <dbReference type="OMA" id="DSKWPSM"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="801"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="730"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1378" mass="147616" checksum="8DFF898C31A3F45B" modified="2012-11-28" version="1">MSKPSSTSDKAPSQAPANASAWSRGPPASNPSSNVASSSPSPSNDAPGSNPVAIGKKGSLMVGGNSDVPRGQPQRLQNADNAGNLAFGTVDSPNPLLSSSPAAPSTTGGHLADAVKSFGSIDAETTATGSSMIRPPRRTSGSTPADAPAARKKLDVHSLFAGKPQQAGSGSSMSPPPQQGSPAAHDRRQSLGQSSFPSNGMPYQQMPGQPHLRPPQGMQGQPRSPVMGGQPQFNPQQSFRVPQNQQQAVRPGNGPMGVPRPMMGQQMPYGMPYNQSPGGYQMMHPQGNYYVSGLTAPVTDPSQYGVSYEQNQYGMPQQWMPQQHSPNMPLSPRSAQAQLGQPSPAPPNAQLPGSAGGSPMPTPPSRPQSLVGGQSTSSPMPTTPSRPLQPGTPFTPQAPAPQTPGLSPGAAAFTPRPKQVIKIARPDGTPVNLSEEAAAAKGPTASSTPETPEEPPRKKMPTLPVLVRMESEEQKKARLAEEEKLKKIKEQEEKEEAERKERRERREKEEAERKAKQEEEEQMAKAAEAAKQEAEEVVEAEKSAEEPKPALTDKEKQDELRRSLMTPAASVVSSPLASPALAAAGLPAKPLSALNPASGSRRPTPSSLDIKSTPSALSSAKPIENLGSIEYPASVKPQSAELNAKSEPGKFRYDRDFLMQFMEVCKDKPDSLPNLEEIGLEADTSSGFGQSRRGNRGPMGSSSRTAPGLGMPMGSGRPFTGNPMGSFGYSGRQGSSGGMPRPRSGPSGGMHMSRPPRGSSGRGHPRKPQNEPDVAPLQVSANAWVNARSAGTDEKSPVYIERKVKALLNKLTEEKFDSISKQILEWANKSREETDGMTLKLVIKLVFEKSTDEAHWSAMYAKLCRLLLDQLDPAVTEVIDGKSVSGGSLFRKYLLGRCQADFEAGWKAREEAALAAMSTNEADKQAAAQSNEGDAPLMSDEYYALQKAKRRGLGLVQLIGELYKLEMLSRGVIRECLVRLLGNVEKPDEEDLESTCKLLTTVGKQFEASSTQPLDPVFDRLKAIVKNDSISSRIRFMVMDVIDLRKNKWQSRKEVVPTTIAQIHQQAARENAEKAQAARESISRGGSRAGHSRREGPQPGEWQSVGATGPRPPQRPTDYSNLGRGVSSAGMAAAPTFGPSGVFARGKKGSASGSTPPLSRHSSTTNMSNMFNILNETGDSAGDAAEAPQRKKLQLAPRTKPLPSKEGSDEESEGEGEVEMTEEAAKNKIKMDAQELWGEKDSGGSRNPEDIVEYYRALPSEYRHLLSEKLCDDVFRIAKLRDAEVVAKGWSAALKENAASLDDLKKGLEGRMPTLDDDAIDFPQAYKAIATIMRSLDLNAEDIDALVAMIDVYGEPKITPKMKLEKALGQVDEEAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU64</accession>
    <name>K1VU64_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU64"/>
    <dbReference type="HOGENOM" id="CLU_1950314_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU64"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="129" mass="13926" checksum="155D8C52C493EBA8" modified="2012-11-28" version="1">MSTGHQGQEAIGLGRTGIEWGFQHFPLRLVSAFSASSAHIAPVSAHRGAFGATRPLPGLLSSPSRLARLLYPPSNDSRAHSVSRPAGLRRYTAVLTAQDRAFLPTSHLRITQPHISPGYKPHSHLVHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUZ1</accession>
    <name>K1VUZ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_01367</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUZ1"/>
    <dbReference type="FunCoup" id="K1VUZ1">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUZ1"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021710_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUZ1"/>
    <dbReference type="OMA" id="NEDYLVC"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="12">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="385" mass="43471" checksum="A00F199A0F8C855C" modified="2012-11-28" version="1">MPAQSIIPDIPGTLLTDPEVTHHLNEHVAQLCHLNQPNFWVCEKSDGVRVLLFVVMNGMTGSQEVWLQYFSVDNLHFTHWESLDDPLTDTILDGELVIDIDPRTGAQVMRYYAFDCLVLNGENIMKKPLVKRFAKAAQRFPEWKENAPFEILAKKQELAYHVSQVLNVHVPQLQHGHDGLIFTCAESAYVPGTDEKILKWKPPSENSIDFRIELRFPPSATDPSEPDYCAKPHFLLNQWMGGDGADAKYEFFDEMDVDDDEWEQMKETGEEYDGRVVEVTWDLKRGGWRMFRFRDDKPHGNHAKTVRSVLHSIEDGVEIADVLAQQDKVKAAWKQREQRNRAAAAAAAPPRPPNGYQKPPPPSAHGGHGGHGGGAPRPAMSGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV52</accession>
    <name>K1VV52_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000225">
        <property type="protein sequence ID" value="EKD04416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV52"/>
    <dbReference type="STRING" id="1220162.K1VV52"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="InParanoid" id="K1VV52"/>
    <dbReference type="OMA" id="NTMGKTP"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="557" mass="62656" checksum="C3634FC58663807B" modified="2012-11-28" version="1">MTRTIRTVIIGGGLSGITQAIRLKKELGDRVQITGSPGGVWRDSIWPEAGVDVPIHLYTLETDLETDWREYFAFQPDVLAYWLRLVDKYELRDSFVFNSEYVGSHWDERTQTHSVTIRNTKTKAQTDITTEVLISATGPLAKRKFPNVPGLKDFKGAWFHNLDWDGSVKLEGRRIAVVGNGSSGVQIVPGLAKLPGTQVTHYIRSGGYFIPKIQREYTPWERFAFQWIPGYLRWHRFGILQEHDRHWSIKFSGDNKQREQDERELLAYLRAKAPAKYLDALTPTWPLGTKRPPLDLGWLDSLHWDNVELVNGALESVDATGITVNGQHRDHDIIVYATGSDIGAHGLGANTRLFGEGNLELEQYWTSIGGPQAYAGIAVPRFPNYFTIIGPNSVAGSWGYTALRETAAVARIVREILDYNLSSVQPKQAVFEHESEEIQKELNKATIAVAGVDNYWRSPGGRITVNSPLSGIGLWWRTQRTRWGDWDAVRLVKGSDGKTRLQHVDVLAIKRRRAAVKALLVAALGATLYKRWDAVVAAFQWAVKETGADKLLQHIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVJ5</accession>
    <name>K1VVJ5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVJ5"/>
    <dbReference type="FunCoup" id="K1VVJ5">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVJ5"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="InParanoid" id="K1VVJ5"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="7">
        <location>
            <begin position="947"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110590" checksum="EAE0E1BD91585248" modified="2012-11-28" version="1">MDGKDPNAVDIMVTSKDPEKEEDLTPKHDKGKQRQDDKEEPEISEEDLQLKTELEMLVERLKESDTNLYLPALESLRTLIRTSTSSMTSVPKPLKFLRPHYEELGQIRESWPKELKEQRALLASILSVLAMTYSDNGKRDTLYHRLISESEEAPGSWGHEYVRHLAAELGEEYTALIENPTDETAAPANGEKQTNGEATTEEEKDPRRQYSVEQLRSLGLELVDFFLKHNAEADAVDLCLELECIEVLGDKVDVNAYPRVCQYMVSMVPLLLPPDDERFLRTAATIYAKHDRLPEALAIAIRLHDRKLVRKYFEAAANPVMKKQLAFIIARANIPNHWVQTLDTMEPETEEGDEWGPPPPELSTELTECLGNSNLSSYFRTFGKAVGVEEPRTPEDIYKSHLETSSSVHYNSARDNLASTFVNAFVNAGFGNEKMIVNPPEPSANFIYKNKDVGMMSAAASSGMSLIWDHEGGINHIDNYTYSEEEHIKAGAYLAIGIICANIRPQPDMAFALLQDNVDNPSSEIKIAAINGLGMAYAGSERHYLVELLAPYVADESSSMDVAANAALAMAFVYVGSGNGDVASIILQSLMEREDAQLDSEWAIFFALALGLIFLGRQDAADATLETLKVIEHPVARSAEILVEVCSYAATGNVLKIQSMLHLCAEHANSKGKSKGDAEDKDEKDGEEAKESKDGDVNMDAASPAAAFPTPGSANANANAAASEDKEDDEEKEEKKAADMRHQAMAVIGIALIAMGEDVGAEMALRQFQHLMTYGDPVIRRAVPLALALISASNPQLTILDTLSKYSHDSDLDVAVNAILAMGLVGAGTNNARLAQMLRGLASYYAKEPDCLFMVRIAQGFVHMGKGTIGINPFFHDRQILSGNAIAGLLSLLVSFTNARKFVLAKHHWQLYWLALAMFPQFLITLDEDNKEKDVTVRVGQAVNTIGLAGTRSGISGFQTHQTPVRVGTTERAELGTNEYFPYSNTLEGMVYIKKNEAYDAEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVM5</accession>
    <name>K1VVM5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVM5"/>
    <dbReference type="eggNOG" id="ENOG502S83X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674709_0_0_1"/>
    <dbReference type="InParanoid" id="K1VVM5"/>
    <dbReference type="OMA" id="GESEMMV"/>
    <dbReference type="OrthoDB" id="2564232at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44610" checksum="AB64E48EB798B8B4" modified="2012-11-28" version="1">MAEFASFEHTPTPRVDPGEKDFVRAYEPKDRDTVEQLIGQSIMEAQAQANNWAPCSAVSSSLAANPISSQRVDRRDHSDPHQRKTFNGGVDGAAHLTFTPRHPRRIPQLCCLRARANPSVLFKPSTILTVLVVGAVLDYVVGFTPKPGDNLSLISPLIGPCLVLIPIMGWVEWKHRGSFLPILRRIVGSPDIRDPGAYYQGGRSKCLLFEHGGQAIGVICLDARQPGEKLESVLGDGTHGSRGPKPADQSSATSTATKGKPGKGEAKQRKADGKNAGSTDAEIRHLTCDLQYRHNGVGTELIAAALDHAFGIAADGTSSGSTGVLRVILCTNPFTRGGEEVWDKTGFKVIKTPDANWRKPDVYGMGKWEGRWMGILKQDWVKRREYLFREGQPQQKETTAVVEEKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW00</accession>
    <name>K1VW00_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_02099</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW00"/>
    <dbReference type="FunCoup" id="K1VW00">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VW00"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002664_0_2_1"/>
    <dbReference type="InParanoid" id="K1VW00"/>
    <dbReference type="OMA" id="NSADYRP"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000958">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="160"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="950"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="667"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="884"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD03622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="999" mass="107373" checksum="FD80CB6A05866071" modified="2012-11-28" version="1">MTTTNGIHTPSYGGVVSTGAEWDFTASPNSARNRSASRSPHRAANDHRSVSTPMSPPGDPSAAVSGSTASASAGNFGARSTPSEEARNYVGRSVTASQQATAQQNSTKGSSPRTGASPGQKQSSTLAPPQAPASSQQSQSQSTGAGGSSRRRQYRQVGDWVLQKTLGQGSMGKVKLGVNVNTHERCAVKIVPRVREDHKSQTDSSGRNKDESKEIRTVREASISLLLHHPYICGMRDFLVHQNHYYMVFEYIDGGQMLDYIIAHGRLRERAARKFARQIGSALDYCHHNNIVHRDLKIENILISNNGNIKIIDFGLSNLYSPHRHLSTFCGSLYFAAPELLNAKLYTGPEVDIWSFGIVLYVLVCGKVPFDDQSMPALHAKIKRGLAEYPAWLSSDCKALLQRMLNTNPQERATLAEVLSHPWMTKGYEGRPDSHLIVREPLRADEVDMEVIKRMQGFTFGTPEEIYDNLQRILNSEQYLRTAAAWEATRERRRSSANGTMGSMNNDGESPKKKRFSGFDLKKKLFKEEKKPDEIQAAVKEPLDPSSGFDPLISIYFLAREKKEREKVYGASHFASSKVSLEGQTSTMNYEQSLASVPEPPSAHASTFDTKAATNATVRDAGTAASARRRPDELGSSAPPATAVMSHPAADAARSNIADVPIAHRRGATTPQVPSPSAPSTPAAPLSAPMVATPPSAALAEDEHAEGVPIPAATATPASGAGASAGAITTAMAGTTLYGRETGVSSNPATVVQATTSEWPVPLGIIQDKSGGIRPIGAPELDEIEPADVANIDVKSVYLKGLFSVSTTSTKSARTLLRDISHVLDRVGIKYRPIRGGFECIHVPSIDLASVVHGDEARSQLHVPQTDSGPLENSPSKNKLTFKQNAASSSSTQQRGDSPAPAGLGTSSVGAGSDGVAPGSSGTVGMLDNASVPSRKLDIIDDDPWGTMHGANSPLCVRFEVFVVKVPWLPLHGIQFRRVGGDGWQYQQLAKTILREMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWM1</accession>
    <name>K1VWM1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_00736</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWM1"/>
    <dbReference type="FunCoup" id="K1VWM1">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWM1"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_1_1"/>
    <dbReference type="InParanoid" id="K1VWM1"/>
    <dbReference type="OMA" id="FYNQGAR"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD04936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="542" mass="60683" checksum="9E7827E6B54BC1B8" modified="2012-11-28" version="1">MTPKPKSYDADRQAKGADTVYTASNGAPHPHPYQSQRAGNNGGLLLQDFHLLDLLAHFDRERIPERVVHAKGSGAHGKWVCTDPLDDLCIAGLFKKGAECPITIRFSTVGGESGSSDNARDPRGFAVKFKTEEGNWDFVGNNTPVFFLRDPTKFPHFIHTQKRHPATHLGGGDDATMFWDYLSQNPESAHQVMILMSDRGIPDGFRHMHGYYGHTLKLVKKDGTWVYAQFHLISDQGIKTLTNEEAAQKSPDHGQKDLYEAIERGEYPSWTMKVQIMTPEQAVEAWEKKQINVHDLTHIWPHKDYPLRTIGKITLNENAKNYFAEVEQAAFSPSHMVPGIEPSADPVLQSRLFSYPDTHRHRLGANYHQLPVNQPHTKYDGSSFQRDGPMAFYNQGSRVGYLPSIDPPKFSDKRVDLDKVHGGFAMTAVSYLSQITPADFNAPRNLWEKVFSEGERKRWIDTVSGHMSTVKDKEIIKRQIAIWRECSEDLASRLEKATGVKGYNGIKGMKFNGSVNAMDSNIILANQNYAGGLGNAGPSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWS1</accession>
    <name>K1VWS1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWS1"/>
    <dbReference type="FunCoup" id="K1VWS1">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWS1"/>
    <dbReference type="eggNOG" id="KOG3478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125172_2_0_1"/>
    <dbReference type="InParanoid" id="K1VWS1"/>
    <dbReference type="OMA" id="VQTEFAQ"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14107" checksum="2C7768FB9ED3CE02" modified="2012-11-28" version="1">MAAAKIGAIQAKLQDESREFQKLEAEMAGVIEARQRLDAQQAENESVLKEFSTLKADNTIFKLVGPALVQQDPTEAKANVEKRLEYIKSEIKRVENQIKEHQEKANKKKDEREFQQLQGPSKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX15</accession>
    <name>K1VX15_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_01686</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 12"/>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX15"/>
    <dbReference type="FunCoup" id="K1VX15">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX15"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="K1VX15"/>
    <dbReference type="OMA" id="NRYTDLN"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD04012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="368" mass="41344" checksum="626EC0C0F5D7E46D" modified="2012-11-28" version="1">MADFVKLSIFGTVFEVTTRYVDLQPVGMGAFGLVCSAKDQLSGTSVAIKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSTGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTIASENTLRFVQSLPKREKVPFATKFPSADPLSLDLLEKMLVFDPRTRISATEGLAHEYLAPYHDPTDEPVAAEVFDWSFNDADLPVDTWKVMMYSDILDFHNLGDIAQNDAEGPVTGDVGTAAAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXG4</accession>
    <name>K1VXG4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXG4"/>
    <dbReference type="HOGENOM" id="CLU_861042_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXG4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="323" mass="36666" checksum="A2A34E9A70A8F4FA" modified="2012-11-28" version="1">MASFPPPNSSKLLFLRRVRTSLSDKVVWKRKPSNGRLPRSLPPSLLPEDYPHVFETIINCLPLKQRLRLRCVCSALKALVDRSYVTLDLSFIFTGRGPADVQAENIRLPYFHEAGDQVLQASAIRRARHVHIRGNTTEWMPLDARLNVWLSHLQDGTVVTIESIKNTAQRPLALPRIQRLDIGREYLQGGEEGRRLFISRHGARELKLYLHIHEYPTHLLDEANFASRGRAVDFLNQGVETLIIAVTWKGFNHAAGHVSNVIRLLFYGVLGAQIFRRLRVRIECSDIAFHGFYGALDLQEDIAGHFRIPTSHVSIASPLRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXK2</accession>
    <name>K1VXK2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXK2"/>
    <dbReference type="HOGENOM" id="CLU_2135286_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXK2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="113" mass="12018" checksum="60A394D26B4BB52E" modified="2012-11-28" version="1">MQRHWNKGNCALTDGPLVAISGGKAEKYNKPVIPPYLAAPIYLKGSESAWNTLYFSADLCSPNQQGNPICEYLDAAVGVAKYLSEHVTGASSIVCKAVNPDGKAQTEKCSDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXS8</accession>
    <name>K1VXS8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000227">
        <property type="protein sequence ID" value="EKD04312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXS8"/>
    <dbReference type="FunCoup" id="K1VXS8">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXS8"/>
    <dbReference type="eggNOG" id="ENOG502RYJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="InParanoid" id="K1VXS8"/>
    <dbReference type="OMA" id="LWNASWG"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="211"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD04312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39300" checksum="36E7E6163AB97BE2" modified="2012-11-28" version="1">MDISHPAARSDSTKVNILLIGLGSIGTIYGYLLEKSGRARVTAVARSNYSLYKEHGVRIDTDRFGVVDAWRPSRVFKSQEEALADGTHYTFCVLCTKCLPDVRSNAEVLAPTIESGQVSTFLLIQNGLGVEEDLKAAIGSTPLLSCLAWISGVTNPAGDVVTWRGIEKLGVGLYPPPSRAQPMCGRSEAALDMWVSLMKSADANVITTDDVVSMRYAKNVWTATQATLQGLTRTPQPCFALVDESSQQLIKDFMTEVVALGYATGLLWEGMTVQPAGTTAGGPESIVQGMWEKFVSKPNPAKTHKWSMLVDIEQGRPFEVEVVLGAVVKLAQEKNFPVPNTRFAYALMKGMQQGILHKIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXS9</accession>
    <name>K1VXS9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXS9"/>
    <dbReference type="FunCoup" id="K1VXS9">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXS9"/>
    <dbReference type="eggNOG" id="KOG3000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041744_2_1_1"/>
    <dbReference type="InParanoid" id="K1VXS9"/>
    <dbReference type="OMA" id="WIKRFWD"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="178"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="266" mass="29636" checksum="88CD4A0A3DA52CDD" modified="2012-11-28" version="1">MPSCTLSSQVCDLELTSARGELLAWLNELLAPNVIQKVEECGKGIIYCQILDSIYGDLPMSRLKMNAKMEYEYLDNFKILQKAFTKHRIPKPACGRANAQPIPVERLVKCKMQDNLEFLQWMKKYWDSNSRGEEYNAVERAGGHRAAPTPPSRGPTARVASGRPSLASAGGAAASRSTSAASNAQIQHLNAQVGELQSTCEGLEKERDFYFASDIELIVGERINLEDVDEQERDTLAKIQEILYQTEEGFEVPDGEEGELLDDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYK3</accession>
    <name>K1VYK3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYK3"/>
    <dbReference type="STRING" id="1220162.K1VYK3"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034129_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYK3"/>
    <dbReference type="OMA" id="ACTSMAR"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="493" mass="54060" checksum="1CBAA50CA91D526F" modified="2012-11-28" version="1">MVVDPFSAASKPMPDWDSIPSRPLPFAATLETLDLNGPGSATQHLPKPVRREKDGLPAAFPTPVYSHDRSPRPLAASGTGRRLSYGSAEQEIGSDEWIQKKVGECVDNARGCGLTVLSTKIADLRDLVTLQQQSPTGSPMRLRSLPLSTASPPRAPFVPRLRDRPFARTQSAPASADALGGQDHVLRARGLLPPAVVEEGASVPGRKANGSRTFTRSRTGAVTMGDKVEGSRPNLAVYLARNLLTRLDSLPAAIGSLIHLKELNISNNNISYLPAAITELPLEQFAAHPNKWREPPAREAKDGGSPRVLSPKASLQPGTVPRLTSLCLSVLLSPRQPLGKPPFLDFDWDDWRRGRSHPLLDVETLADLLPPSLRDKGLGRILQAVRSACTSMARERAGVDFFPRSNEVLRPDNASDNPYYRPCPSPKHQEWQQGEEENVRVTRRIFLDAAEERFEWVTVAGVPNLPIQWLGCSPGCLDFLEDDDDEWLEHFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYN5</accession>
    <name>K1VYN5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000309">
        <property type="protein sequence ID" value="EKD01878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYN5"/>
    <dbReference type="STRING" id="1220162.K1VYN5"/>
    <dbReference type="eggNOG" id="ENOG502SWPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608336_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYN5"/>
    <dbReference type="OMA" id="ILAPSWE"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="440" mass="45031" checksum="1EEA8FF6CA935FA6" modified="2012-11-28" version="1">MQQTPGCLPIPNGGVTRQPSFGDRQFMLNVQGTAPGAQIPRWGPDILRSPGILAPSWEAPAPPNPSTTMLTDHRTPPGGPSGSPSSNPHSGLHPASYNALTFSALALGAAAPGSSPYSSSMAMSISPPRWGPGSLTGSLGASGFGLGSGFGSMGSGLSGSGGASGASFVGSVGGTLGTSFGRQAEGRERELEAKYVKDFTCCGRQLSGLHELLEHYEEEHAGLAADVRMAAINAAQTKTTTFASNIGTMSSDVPSTPGMMDMDMDMDEPSVLSRPPAVAALSLNSSIPGTLPGTLPGGISSASASPWSAAFRPSNLQPPACVPPSVLSYPTPQPQPAPASPAPKLSQEQLAAKALKKAQKKAAQTATPPNETENGDATKDQTPEEKGEKRFRCPIEGCGKVYKQANGLKYHLTRSINSGHGNVAAMGGLLSMLGQDEDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ64</accession>
    <name>K1VZ64_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin lateral binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ64"/>
    <dbReference type="STRING" id="1220162.K1VZ64"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104738_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZ64"/>
    <dbReference type="OMA" id="EQWETKY"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="166" mass="19438" checksum="A3AC15DEF610F6C6" modified="2012-11-28" version="1">MDKIKEENGLTNVQRFTLLQQKIEAAEERAEAAEAENKKTLLERDQEISSLQHKLSLAEEEADKAEEKLKELKGSAEEGDTHRTASENYQRKVQLLEEELDKAEKDLKETTEKLRQVDVKAEHFERAFQRAEQERDEWERKHGEAVEKFEQSKRELDEVVAQMESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0Q1</accession>
    <name>K1W0Q1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0Q1"/>
    <dbReference type="HOGENOM" id="CLU_2098546_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0Q1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="116" mass="12793" checksum="DA9C2B26DFB89533" modified="2012-11-28" version="1">MIPLLSRLLDTQTTAFQAHTRHAPQSELLRGMRGPSIATFADHVLRGGRRERVVKRDRLSTLHVEPLASSDVLEQTLPLPVLICVSASAWLRGTAVFLRWLSDTVAGHTLHARAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3A0</accession>
    <name>K1W3A0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000256">
        <property type="protein sequence ID" value="EKD03368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3A0"/>
    <dbReference type="STRING" id="1220162.K1W3A0"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_6_1_1"/>
    <dbReference type="InParanoid" id="K1W3A0"/>
    <dbReference type="OMA" id="GPWEKID"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30870" checksum="BDCF941078B73CD9" modified="2012-11-28" version="1">MGLRSFLYFFLQPWIFLCLATLHLPLTWLAIIRSGDYGALLSPSRFKEKWFAVLWLTAGPLVRAESEPRVKPLLEGRVLRGCITKSAASTPLKGSVMEIGAGSGMWAHLFTSKTVDAVYAIEPNMQQHPALLKRAEELGIRDKYHVVGKGVQDLKEGEQPQVDNIVTIFCFCSIPDPAENAKAVYKFLKPGGRWYVYEHVAAHPKQGDFMRSYQKMINTIWPQFFNGCSLCRDTGRTIEQAGDWAHVDLAMPVDEGWYAGIPHTIGILTKPGTMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3E2</accession>
    <name>K1W3E2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000252">
        <property type="protein sequence ID" value="EKD03408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3E2"/>
    <dbReference type="STRING" id="1220162.K1W3E2"/>
    <dbReference type="eggNOG" id="ENOG502S4M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092522_0_0_1"/>
    <dbReference type="InParanoid" id="K1W3E2"/>
    <dbReference type="OMA" id="AIQAMCD"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="212" mass="23468" checksum="02566E9CDF2A4A78" modified="2012-11-28" version="1">MSAQLPPLDSLTDPAKLTQCLSTLFEPSTALKEILVPQLVKKYKADGTPLSYAGVIHDCAEASKEWTWEQKSDFVTGHPLIGAPATGLSGKEQGTETTKVVLDRLQHTANINGAVMSLKQLNSLYSQAFPDLTFITFVNGRPRSEIVNEMERKIGLPESPKPLPDSFDCSSTTIDPKLVRKKGSPEWEEECDRDVNDVWRIARSRLRTLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4U8</accession>
    <name>K1W4U8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4U8"/>
    <dbReference type="HOGENOM" id="CLU_051553_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4U8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="435" mass="46657" checksum="DE5CE1FD23B6AE6E" modified="2012-11-28" version="1">MSRRLCHTIFILDPSTSPVCAKHEPMRTVGRVSTYRVGKLAATSGTLVPSPLMRAEALALSEFDAIDERQPTGLRDGHRTAEDSTAVETVGDCKLSRGSLEALVVGISDTPVSSGLGHVPMTSMNTEPSIGRCFGTFGDACLLGGLEPTGTSAGCCCRLSTALSGPWLRVRSESVLRRSFHITSRQPVTSSTTPLSLLSIHELDLQGTSKETAMVAPPPAANQNNLPPEGGLVQDALLGMKYKYIREQPTTLVVTITPQGKGHPNSYHVVDDKGLLIIQTKSDGSKTNIIFDGEGGELLCMSPNLITMHHSISGTHGGQDVYKGSVHSGYTDAHPAGGESEYRATYTNHDTNVTTEVDYYGPWEEHDGKIIDHSQQDRVLANVCRENIFDSNMPRIAAAGPGTEYFLQVVAGVDLASVATIAVGFDMILERDHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6E4</accession>
    <name>K1W6E4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6E4"/>
    <dbReference type="eggNOG" id="ENOG502TKWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834239_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6E4"/>
    <dbReference type="OrthoDB" id="2574664at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="343" mass="37370" checksum="AF82545EC17B6BD4" modified="2012-11-28" version="1">MAEVAARKRARSSSPVCDVLASPLEVLLKRRRRDLSRTSSVALPPPSQPIFDPPGGTGGDTAMPSSSSPGGLPSSSSPGFENYSHDANSLRGIERRRTRNWERLNAPAHAGPSCEPDSSPVARRSMSDRHLVSSSPVRHQPPAPVFRDEWSAEERLREWGDEYASQNSVLHSLVSRVVSMAISGGRWYSCRFEVEIANMQHLARLESQQSLHSLHSVASAAYSPFELAEPASSPAPMPSTTPLRTPASANPWRTHQTPGFTPGGFTSSEYVSSPLFSPPPHSGPHHTHATPSRTGEAHGEVRASYEETNRLLAELNFARLRRHDAMSSSPPPPSTDPAMDEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7C7</accession>
    <name>K1W7C7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">A1Q2_00899</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7C7"/>
    <dbReference type="STRING" id="1220162.K1W7C7"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030200_2_0_1"/>
    <dbReference type="InParanoid" id="K1W7C7"/>
    <dbReference type="OMA" id="AWQMGLT"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854236" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="182"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EKD04788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="472" mass="49242" checksum="19E88AB68E92208D" modified="2012-11-28" version="1">MAALATTVLVSLLSVVNAQAAAAPAPAAASTSAAPAGAAAAAPNPAITVAIDPSLPQSAAQTGPQGFVIPSLSALTSGAPTDKTVALHTTFAVGATPSVSSAPAIPTTPKSTDYPPLDAIPDVNSPEVKKWVSEIDWDKVPKYGVTTGECASSPEATKDGRCWWTCGGCTRDTDITVCPDQYTWGLSYDDGPSPYTPLLLDYLEEQKIKSTFFLVGSRVVSRPEMVVSEYMLGHQLSIHTWSHPSLTKLTNEEIVAELGWTKKAIKDVVGVTPNTFRPPYGDLDDRVRAIAAQMGLTPVMWTDYQGTTFDTDDWRIVGGTASGPSSLTKFQRILDEYVPKLDTGFIVLEHDIYSQTVDLAVGYFLPMAIASGKYKMKSIIECLGLGNEEAYIETSSNTTNTLILSATGTGTVYQASVGSVTGSAPVVTASSGNKDAKATGSEAGKENASGANALAASLSVALAALVAGIAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7T2</accession>
    <name>K1W7T2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000404">
        <property type="protein sequence ID" value="EKC97698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7T2"/>
    <dbReference type="HOGENOM" id="CLU_1670629_0_0_1"/>
    <dbReference type="InParanoid" id="K1W7T2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="158" mass="16458" checksum="EAEA74420D116343" modified="2012-11-28" version="1">MGAGSLDYVRLANDLNLIRGPGKSGDPAVAAAAQILPPPVRWAQDLPSPLPWERAEPHTGASDAAGVAGDTGDTGERLWPGSWEAAPACRFGALVQVGGRNAALQQCFPDPPQSGSHTWAGPNEGEQDYQSVPPGRDLASADFAILHHTHPIPIIPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W884</accession>
    <name>K1W884_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W884"/>
    <dbReference type="HOGENOM" id="CLU_734010_0_0_1"/>
    <dbReference type="InParanoid" id="K1W884"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42071" checksum="27C16F797C224535" modified="2012-11-28" version="1">MSSDHEPVPSDYLPSEIVDKATAPLDMDVEAEEHSAVDQALSLSETIFQPLAKDIGTQTDATIIELFKRYVTRDWVTSVTGPSLPIHPSFTKGDIVLVSSDNVAFAFPLGVLAYRSLVFRGLAELPRSEDSSRVLPITMASAKTLEILLARLHSDHSNRLVTVPSVEVLDELLAVIDAFDFQVSIIKSAVCQSDLNVGIKYAFASAYDPANENKWAVECLDVRLFSRCEQWAQHPEAHRTLEELFEKWQAASTTFVKAYERTPVNGNDNFGKRCRKQPCEEYKRGEWSSVKTVVGILIAYAMMDSPKSDRGFIMTVCAATLGCRTCEHRLAMHGAVIWKEVVERSRDVHTCLTMSRCTAIVKGRHVTERPPMSFVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8G1</accession>
    <name>K1W8G1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall organization and biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000145">
        <property type="protein sequence ID" value="EKD05098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8G1"/>
    <dbReference type="FunCoup" id="K1W8G1">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W8G1"/>
    <dbReference type="eggNOG" id="ENOG502QQTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071622_1_1_1"/>
    <dbReference type="InParanoid" id="K1W8G1"/>
    <dbReference type="OMA" id="GYWEFAK"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF2">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852767" evidence="1">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="237" mass="25291" checksum="49A7A6E04C9E6AD6" modified="2012-11-28" version="1">MLAVPLAIAALVAPASALSMADLEGTWSSGTNYVSTGGDFCNPSLSLFNVPNNTGMSYSFTADGFFEEAQYRYKSNASDPFCISSVLWWQHGKYKINDDDTITMTPWATDGRVQTQTRCGGTTEAQVYYYNEKGTFKSFDVQVRVNPAKPKEGANLALITQAFDGAKNPPMYLIARPPNMLPTQVLTGTNSSGSTVGRRSFIPAQVQSVEKRSKSAAMAAVAAPAALAAAGLAAIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1W951</accession>
    <name>K1W951_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup160</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W951"/>
    <dbReference type="eggNOG" id="KOG4521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002799_0_0_1"/>
    <dbReference type="InParanoid" id="K1W951"/>
    <dbReference type="OMA" id="MDFTRYR"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="84"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="6">
        <location>
            <begin position="941"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="5">
        <location>
            <begin position="1204"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1445" mass="157153" checksum="07829C271F18FA6F" modified="2012-11-28" version="1">MSVYSPFQLSHAHLPAPSNDDAFEVTVPSERPFPETTEPYTSPLNADHAVSAAVEAATGIFARSIYNGYALELRSLSPVIAAGSGPLQHAAIRIMLPDQLRPLANNCIVPSTTDGKLYVVVVTQANVVYRFEFDLGSFVDRGDRITFNPKHDWCEEWEVNEELISSAGEVGSWSIANQDTVILGCGDGGIIQVARTPNSTSEEHHRASHRLFGGLFSRTVDETVTSIAEFDLVDQMPVMYTFSRDSKLRTWSSVSGHCLKTMDVRTPSTQALVQGTPTMQQLPEATTSLIRVVPHPSPNPRVSHIVVVFVPTPFASNSAGIFVFYRGNNGAHHANDLVYAAELPASSDTAGWNLRGFEIEPPLRTDSKDGWRLWTAWDDQGTFVAESVPVNHILQFTTYLEPSFESDLVFSWQRAAYDSEVDRLDAPYFDNILGLEAPEPTEPYNNSDIAATFIDHLFFPGRFSQLNLEAALDDYIDQLPQAKQDQLLLNIYPSLSSKFEAAVGSQLRMETSPQTGAPIVDQFRKQLKLEWLGIWARVRELDKQGRWPVGTASMNGQVLILDREGGSVPVQEDTPGVLVDLGAHTDKATRFQALPEGALLPQYAPLAPPQSRRCLTALAVAGNDLATALQAQEPHPHLVQEEARTPLDDVISYASAERNSALDAFAAAFDEVLGQGASMPVENLAGALWDDMVEPYITDGQREAVQRALSESSDITRTLSEALDILATPPPPISGGKEAERWSFSGFGNALLSSAVANVLQARYVLARNVLLVSLWHLATSPDPSAEDDESEALIEVLARAQATYHRYSVGRWVSEQTGEEAAEASRVRRAARKDDVLAEFDGLRMRDTPGGDGDYDTAYSLLHSLLASELAQAPPADTLAGLFDAASAFVASLDLLSPDQIDVEPEAADVKLAYAVLSDGHPRAAVELTERYPLSSGMAFVRGRALLERGDQEGVRYLELAAQGCRDGSLACILPACTSPNALGEYYRRALAIADEHGLDSAVAHFGTLAISHMPDSDTRALYTRVFLAHLAQGEYEAAYSVLTSAPHHDIKRDLLGQLISGMCEAGQVGRLTRLGFIGFQRDVEERLTFKARNSDPLKAPNYYRVLYSWHIARGDYRSAAEIMYAQGQRFASLLASSSGRISPYSLSAMQAQSYLAAINALALVDKRNAWISVLTDTPQRTSSNIPKEEFEDGTGPVDIVTLQDMRAEYATVLGQLKLTGANPNLVDAAVTLSAAELVGLFTQRAQFDDAFSTAAASGTDMTDIFVAVAERCVDLEQRPNASVDGYNSSEAWLAASPITARLRGSPSALAQRYLQTSLSRHDTAKTGYRYTSSVADVFFANARSMPAWLASAEMARDAESFISRALAAGWTREALGWASELLGGLTPPDLLPKRDAAADAPYNLLDRVTAAAKQAEEAEIKKAAEEMKSQIGKRVEGLKAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W958</accession>
    <name>K1W958_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000106">
        <property type="protein sequence ID" value="EKD05358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W958"/>
    <dbReference type="STRING" id="1220162.K1W958"/>
    <dbReference type="HOGENOM" id="CLU_1595721_0_0_1"/>
    <dbReference type="InParanoid" id="K1W958"/>
    <dbReference type="OMA" id="WCAIIST"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="167" mass="19007" checksum="7C6E65DF472D1265" modified="2012-11-28" version="1">MYFNTKRVLDRQQARWSVSLSRFNFSIEHRPGVKSGKPNVLSRQSDHALTDADATEERILNLFAAQLWQLESLSHEAIRLAQQADNHSRLLADRLREDSAAAGEKDYKLDPKGLIRWRGRLYVPDTRELRLRIMEENHNAPMAGLRARPGRGSWCAIISTGRASGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1W992</accession>
    <name>K1W992_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07495</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000395">
        <property type="protein sequence ID" value="EKC98163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W992"/>
    <dbReference type="FunCoup" id="K1W992">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W992"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="InParanoid" id="K1W992"/>
    <dbReference type="OMA" id="MCHDHFY"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="81"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="296"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="834"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1067" mass="120952" checksum="66193ACAEB4589C9" modified="2012-11-28" version="1">MARSLSRSPRRRDSTESEDEGDRSIKRVKLERTAATEEPEDDPMDYDPSDLDDDEKNEQAFNAARARRGRYMGTVSEAGVLKSINLVNFMCHKNLTVQFAPRLNFLVGHNGSGKSAVLTAVAVALGAKAAITGRGQGIKDLIMHGAEYTDDIIIERIIDRNGTSQYKFRTVRGGNIIEKKSIELKNIMNHFNLDIDSPLTLLTQDAAKSFLATTDERKLYSFFLRGTNLQFLADSYSATQSTVLKMEREVAAAKEAEPGLEARVRRLGAQIQVARRVADIRLEHDRCRRELAWSYVIQKEKDVDDMTERLDQEKEKLKQVEEEINKHKLTEDISELETEAQEDLNEIVPLKLEKKDAKKELAKAESEESIEELRSEIKKKKAEVADLNKKIAAKARDQGSAVDPQMEALRDKIKHHQGLLQNMTRAQPTKEKEASDAEAACQVAEQVQQAKAALRDEAAQALDQARRNLQPFQRASRDGLEKFGNNIRLVMDRIQKATWRAGTPLGPLGRYVQLEDESYRGVLESFLGGLMNSFAVRCDEDRLTLLKILTECSRGTNGYAVAGIASKFPPVLQWRGDMFDYSRGDLSSRGETILSKLKFSNEEVLRIFINQARIERVFERERPDYGAQCGYEEPDGSSQLNPLPNWRGPGLFVRDTEAERRNLEGRVQVAEQERDRALAEMDAAVRAKRDADGKLRAANRLQEGRLKMERSLRQFDDELEKLQPTTGDALISTRSEVEAEITDCEKQLALQEGALKRVMRAQREAEDKIKELDEKLNSGTYRQKKRTELQQTINIRKEGQKRYEGRITVMTAELEKVQRMAIEWSVKAEGFGERVETTRTSEAIKKNNDSLERQLKEAEKQTNINLDDLTANYEEALQKLNESRTKIHGVETLAAELKKNVIQRQTKWQELRHHVAVRARTAFIANIHKRGFDGRLVFNHDNETLSLRVQTTNVGKETQGGASQYTKAPINLSGGERSYSTVSFLAALWDTSGNTIRCLDEWDVFLDMVNRKIASNLLVDSARESDNKQYIFITPQDMAGMTAKANEKVIRMSDPVRGQQTLPFAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9Y9</accession>
    <name>K1W9Y9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clathrin heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9Y9"/>
    <dbReference type="STRING" id="1220162.K1W9Y9"/>
    <dbReference type="eggNOG" id="KOG0985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1251458_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9Y9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="CHCR" evidence="1">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="221" mass="24699" checksum="50017A8FF3F5D8E0" modified="2012-11-28" version="1">MPYKLQNAAQTTQKIAALEKELAELKTKQKAAEPEEEQSTGMLGGFGGRLMIGGPGGMNGGGMMGQPTGVHDRPGYPFPRTSWRPVAISGPFRPRDINRPRIANLAEKAGLAQRALEHYDDINDIKRVVVHTPLFNSDWLINYFGKLTVEQSFECMREMLKSNMRQNSAIVVQIATKYSDLLGPVKLIEMFEQFKSAECLYYYLGSIVNLSEDPEVHFMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAR4</accession>
    <name>K1WAR4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAR4"/>
    <dbReference type="HOGENOM" id="CLU_1846506_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAR4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15997" checksum="D4523AED0D1D16DE" modified="2012-11-28" version="1">MESQAGQAFQAANPQAWDVHDDAAIEQEMREGQRRWHQEWVKEYTNALDKARQYNSSTRRGLAPLPTLFNCPRIGPLPLKPLLHPAPPKFPTTLLRLRNMNESDLNAVLRGYHLDTEGTAEERRERLREYIGAGSNENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAW8</accession>
    <name>K1WAW8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAW8"/>
    <dbReference type="HOGENOM" id="CLU_1751000_0_0_1"/>
    <dbReference type="InParanoid" id="K1WAW8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="184" mass="20366" checksum="BEB5C7FFFF44050A" modified="2012-11-28" version="1">MCNCFGLQHSPTLKPCSSLMDLVQEKTTTSVDLDKMECRLQALEKFKAKFEAANVFARLDALEKANTPGLATLDADQFIRRMETLERRILPAAHEAEIERRLEALVQLTSDGPPTDGTHANVTISSNQAVSCSKSSNDGGHDYIVSQMIPEAVPHECAVDRREESAKSVTDRTELVSRRTETEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1WAZ6</accession>
    <name>K1WAZ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000380">
        <property type="protein sequence ID" value="EKC98823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WAZ6"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="InParanoid" id="K1WAZ6"/>
    <dbReference type="OMA" id="EMTFYTG"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF17">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54578" checksum="5B3D23B1C58C5A94" modified="2012-11-28" version="1">MSRTGKLGDRLAAIKVGGFRYNSPWTQVTLTGIICFLSPGLFNALSGLGAGGTDDVITINVGNSVLYACFCLMGFLSGSINNVFGPRLTMCIGTMGYSLYVGSLWAFGIHGVHLKAFVIVASGILGCCASLLWTAQGAIMMAYPMEKDKGRSFSLFWSVFTMGGVVGSAIALGITSKQKEGASVSTAVYITFIILMIIAIFVCWLVLPPYYVVRGDGTVVKLESDVGVLHEIKAFAKQFLDWRMIMLFPMFFTSNYFYAYQGSIVSKMFTPRGRALAALLSNIGAVFGAIVVGFVLDYFPGGRRRRAIAGWCYTLFMLCLVWGAGIGFQTRFKRTDNNGDSLGWDWNDSISHGPLTLLFAYYFCDSAYQGLAYYTMAGLTNDPYKLARMTAYYKGVQSAGAAISFGMDALKTPYLTEVIVSFVIMLFSMPFCLYILWGFKESNYDAEGVVHVEELDEDQVHHAAVPAGHHTHPHDIEGAHPTDEKNSAELQIENPQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBF1</accession>
    <name>K1WBF1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBF1"/>
    <dbReference type="HOGENOM" id="CLU_1939602_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBF1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="130" mass="13428" checksum="10A9865CD35BC2B8" modified="2012-11-28" version="1">MKRKHGSDSGSDSAADSAADSGSDFQPSPTPAPVNKKPNVKPDIKPDIKPKVTKSPTKRASPSKAGGSGKLPPGSKAALASLIVQRGLASLPSHAECAEITGMTPAQVRNQLDPRKGVRKKLQKLAETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC25</accession>
    <name>K1WC25_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC25"/>
    <dbReference type="STRING" id="1220162.K1WC25"/>
    <dbReference type="eggNOG" id="ENOG502QRUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044153_2_0_1"/>
    <dbReference type="InParanoid" id="K1WC25"/>
    <dbReference type="OMA" id="HNEQAYT"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="67"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="385" mass="42465" checksum="ADD5227A2BE46319" modified="2012-11-28" version="1">MAAVATAPDTPLGTLPTEAAAYFEPFALPASNQRQLSAPHAPGSVAPLALRPSKEITLDEAVSTISDLQKTGVLTSLLSQHGALLFRGVPVRNPADFSRFAHAFGYAPHEIIGLVVERGELAPNVSPANESSKETLIFNHNESPQVPHAPEYIFFYGHRAPKEGGETPVSSSLELFRRAQEEIPEFIEQLAKRGVRSSVTYKRGRQYAGGTTMQQAFGKEWAEDDDEETKRRKVEDQIRRYGRGEDTTWEWTDDGGVIVTHILPAIRTQPGTGLPVLFTGLAAYYRNLVVNGKQRYGVSQTYGDGQPIPEEYIKRLAEITDEITVLHKWQEGDLLVYDNVITQHGRHPWKGEQSDRVVYASLFDGEAPGAYGPQSWAKSVKALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDS3</accession>
    <name>K1WDS3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000364">
        <property type="protein sequence ID" value="EKC99748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDS3"/>
    <dbReference type="HOGENOM" id="CLU_115068_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDS3"/>
    <dbReference type="OMA" id="ERCELEP"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="22035" checksum="37F688DBB61EB376" modified="2012-11-28" version="1">MAMQSPAVGHPPERCELEPSPEQNEAVENLVRCADNVKAAGEEALREALGIEHRAKDVARAASDDVVEPHHVARVLDALPERDVAAGNDGRQTQANEGQRAVPAMSAVMRREHHVARCDAGADDAGHVHDLQTGMAVEAVVHARQDGTDDEHDDADLALASNLAPVQAVGVVLAVLPVRGRLDHEPAHGVNVDWSPVRFDADDDVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFJ4</accession>
    <name>K1WFJ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glutaryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFJ4"/>
    <dbReference type="STRING" id="1220162.K1WFJ4"/>
    <dbReference type="eggNOG" id="KOG0138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_1"/>
    <dbReference type="InParanoid" id="K1WFJ4"/>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="267"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD00344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="421" mass="45960" checksum="DC31B91E4915281B" modified="2012-11-28" version="1">MVRLAAVRPAVNAITSARAMSVRGMAKFAQYNWEDPLNMESLLTDEEKAIQETARDFAQTELMSRVTEGFRTEKYDPEIMKEMGKLGLLGPEIKGYGCAGASSVAYGLIAREVERVDSGYRSMMSVQSSLVMHPINEFGTEAQKEKYLPKLASGEWLGCFGLTEPNHGSDPAGMETTATKTPEGWELNGSKTWISNAPHADVFVIWARVVENGQKGKVRGFVLERGMEGLSTEKIAHKLALRASVTGSVFMDSVKVGEDALLPKSNGLGAPFSCLNSARYGISWGVMGALEDATARARAYALERKQFDRPLASFQLVQKKLVDASTASTLGLLGSYQLGRLKGEGNYCPDQISMMKRNNCGQALYHTRVLLDIFGGNACSDEYHVGRHEANLQVCNTYEGTYDIHGLILGKAMTGHQAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFM6</accession>
    <name>K1WFM6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFM6"/>
    <dbReference type="HOGENOM" id="CLU_2198835_0_0_1"/>
    <dbReference type="InParanoid" id="K1WFM6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="108" mass="11700" checksum="49779337834ED42B" modified="2012-11-28" version="1">MSPSDTKASAFPDQKRSADEMDNTSSDEEKPDVSSYDPSPSPPARGKGKAKRSNNTRSPKKAKTTEANGHWSADARGTIVKYIFDRGTNGLNYAELSALVRRLPLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1WJM1</accession>
    <name>K1WJM1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WJM1"/>
    <dbReference type="STRING" id="1220162.K1WJM1"/>
    <dbReference type="eggNOG" id="ENOG502RV8U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1391117_0_0_1"/>
    <dbReference type="InParanoid" id="K1WJM1"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062064">
        <property type="term" value="F:box C/D methylation guide snoRNP complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674:SF1">
        <property type="entry name" value="NOP PROTEIN CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674">
        <property type="entry name" value="SIMILAR TO DNA SEGMENT, CHR 10, WAYNE STATE UNIVERSITY 102,-EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="196" mass="21222" checksum="4A1C5160BEBD924B" modified="2012-11-28" version="1">MLRGSADKYPHGKCGMIAAQIEARSGGPPHPHSRIVKTNFSSVDTHPPSPLRYRATMSEDKLGKQNKVEKLDVESDQDRKARLGELRETNTPVLARARAFLPQLAASNDALLARAREDPSSVSIENPTGSHVAMDLGVGVFDVKGDAPSGVPVVEGEEWTKGESESVLSSESSDSSDEEEEDVQIKEASTTRKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNA0</accession>
    <name>K1WNA0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNA0"/>
    <dbReference type="STRING" id="1220162.K1WNA0"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="InParanoid" id="K1WNA0"/>
    <dbReference type="OMA" id="EPTRYPF"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="307" mass="32812" checksum="FCBD5F09AEC69D77" modified="2012-11-28" version="1">MKALQVKELQHHSKLKVILQSQGKYQNQPPLPFVLGAEFAGKIASDSPIPDGCDFKRGDRVFGYAQGAYSERLALNPVTLLPVPANISLEQAAGLFLTYPTSYEALVGRAQAKAGETMLVLAGAGGVGLAAVQIAKYLGCKVIAAVGSEAKFAVCKNAGADHVINYSEAGWQNKVKELTDGDGVDVVYDPVGMIVPSLKCVNWNARLVVVGFAAGTIEKIPANLILLKNVSVVGLFWGATSYKDPARFQTVIKEVLTLIAKGKLNPTVYEKVYEGIGGVVEGLSDIEGRKTWGKAVVRIRREDKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNY1</accession>
    <name>K1WNY1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNY1"/>
    <dbReference type="STRING" id="1220162.K1WNY1"/>
    <dbReference type="eggNOG" id="ENOG502S7GA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122036_0_0_1"/>
    <dbReference type="InParanoid" id="K1WNY1"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="181" mass="19696" checksum="A466B2464188940E" modified="2012-11-28" version="1">MLRYAARPLRAARGFSTSAPRRGGHSGAHGSAEHDTVENFMNATWRNAFIAIAAVALAVKYGPSPIEGVSASPSVSNDNLEKEAADKNAPWITRWYANNMKGDGKLWDERNAKHLELTMQAADTRLLYNEAELPHVYRLKNPSSFLQASPHSIGVGTQANLNGTVIKEDGSPDVTLKDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WQG3</accession>
    <name>K1WQG3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wos2 protein (P21)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WQG3"/>
    <dbReference type="FunCoup" id="K1WQG3">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WQG3"/>
    <dbReference type="eggNOG" id="KOG3158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="InParanoid" id="K1WQG3"/>
    <dbReference type="OMA" id="WWTKLLR"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="249" mass="25838" checksum="7BF2E5BFD0C31BC6" modified="2012-11-28" version="1">MSAGKPIHPEVMYAERSSDTDPEKNFIYLTFRIDDLNPGYKVDLKSDSLSFTGTSGDPAKGLPEKQWACKLNFYHEIDPEATKQMPYTGRDLLLIIRKKELKKEYWPRLTKEPLNRNWIKTDFTRWADEDEQDEVAGEIDADDGGFVGGAGGGGMPPGMDMASLMGGMGGGGAGAGGVDFAKLMEQMGGAGGAGGAGGAGGMPDLSALMQQAGAAGAGAGDDADAKDGDEADASDAKAADASADASASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRG6</accession>
    <name>K1WRG6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000245">
        <property type="protein sequence ID" value="EKD03609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRG6"/>
    <dbReference type="HOGENOM" id="CLU_660878_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRG6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="416" mass="44305" checksum="F434A8AB93BD1F58" modified="2012-11-28" version="1">MRLLHSFVSSGLTGSLMARVPGTSGLSCPRPQSVPHACAAAAVSADPRCGHSIPAISAGEVPFEAAQPPRPSGRGTGEHVFVPVLKADDRTCYSANRTCDEELEQRQHDRAKEVEALAVCAPAVIAEEHSHAADVLEVEIPHVWEQVAPSEVHDKEGIEHLPAPGITVYDALTRLLRLVGLEEVVGHHTARVAYQPGSGSRPRRADATPRLAPRTRAIRRVPEIALVLLVAPGRGEVEVIHLDDERIDVNHGRSVHLDRAAAEGAQGHGRYRTLPAPYASSRGCDPDPPMKSEQQVDFILDLAAYESQGEKRAPIGELDDRREQVREIEERERARVGFQGEGGCTVLDSWCGGVTGGGPSGEVGGVGRARLRGRPPGLGVAVAFVFASGFSFAFAVLALTFALAFAAARLATLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRT4</accession>
    <name>K1WRT4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRT4"/>
    <dbReference type="eggNOG" id="ENOG502SC01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018694_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRT4"/>
    <dbReference type="OMA" id="DIEMRTY"/>
    <dbReference type="OrthoDB" id="2575575at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="810" mass="86210" checksum="36886A4C9F48C4F1" modified="2012-11-28" version="1">MKRRRSASDGHPGPPRQSTSSPWRWNIGGPILDFGDEAVDAGPSTPPCACDDCVAPRPSSTYRSSSSSSSSRRRASRSARASFSGTDSDDDDLLASSTSNSTPVAATSRRRLRKQRDSSSRPWSLMRPLTTALALSLATAPLAAAGPVPLPSRSTTLTAATDTSSPPPTRTIQSSITTAPTDTPTTVPTKTQTLQRRKIESVSLFEEPSLLPSATLATLSAEALPYVVTQSSDGRWYHDPRPWWIYGVVMEHQEPAAHSNDMITNERRAADADANDMIARAQTTGSPRPADKYSVVSSLPKGWGESRVDRSEFYRTPLIVAASVILAILIVTGLIIFAIQRRVHTRRKRRHTARMRRKALAAAGLTEDDLKVGGEDAEVAFQKKLKEVETAYEIKHRGKAKHHRPTAIVRTKVRVWRGGMRRRKPTPGDELKPATSPTGMSTAIVLNQNGSVVSLATTATERTTSTRSSSRSTHHSRLSIHPSNSPTPNTSDQGVSGASEGIVSECTPNSPSMSSNNDPSQGSSEPTQSSPEVAQSSTPPSNMPPAYRPASVRSVEAGPSRGAGSSRGLRPPQVYGPLAPEKRSAGFYPAPTTPDAEEAQAVAQRADAKAPIIPPPEDDDETRMHVATDDKGALERMRLGASAPPVMRVEDADGAGPSAPVFEVDEAGFERLEGIEEAAETATAPQTPAATTDMPAPPTRVLLRSLRTFSDAPSRTESSALLTLPSTPAVEHDYSLTPSAPPLGLGLEPDSPAPSAPPLANDDDDGDLYEATAPPASDDGSDAGDGEPQRDPTQATLTVNGHRFLPVYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1WS23</accession>
    <name>K1WS23_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin remodeling-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_01812</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WS23"/>
    <dbReference type="FunCoup" id="K1WS23">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WS23"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004447_3_1_1"/>
    <dbReference type="InParanoid" id="K1WS23"/>
    <dbReference type="OMA" id="REMYRIP"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIRM" evidence="10">
        <location>
            <begin position="120"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="361"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="585" mass="62323" checksum="40BD2A28B0F851FC" modified="2012-11-28" version="1">MSTPKISFKVPKEGTEGSADPETQGDVTAHDLSSAPGKEREREPVFGGDIANISNEGQQAMDVDDHNGENAPSATVLPAASPSLDQPAGETPAGADASRLDPNDLHDLATTYLASQTHPLVVPSYSSWFSMSTIHPIERKSLPEFFSKRNRSKTPAIYKDYRDFMINTYRLNPGEYLTVTACRRNLAGDVGAIMRVHGFLEQWGLINYQVDPDTRPAPLGPPFTGHFRVTLDTPKGLSNLHPGTKPGAGAVGAASGITPHASNLDLKKIIYQSSSRSSKVGTEGDAERAAQAAANGAAPRPQAYACETCGTDCTRTRYHSLKDGEYTVCPACYVSGRFPSSMFSGDFVRLDDEVFKHGAQGAGPDWSDQEVLLLLEGVEMYDDDWKAVADHVATRSKEQCIAKFLQLPIEDQYLSSDPAAQLGPLRYQAGVNGVPFDSAENPVMSVVTFLASAVGPAVAAAAAQSALGELAQGLKRKRTEKEGEKEGEKEGEKEGEDADKRQKTDEIKVESATPAPAGDKEASSTPADGTPDPTAPSKSSLERAASIALGSAAAKASTLASHEESRLRTLVSRLVAAQARKVEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWT9</accession>
    <name>K1WWT9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000142">
        <property type="protein sequence ID" value="EKD05159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWT9"/>
    <dbReference type="STRING" id="1220162.K1WWT9"/>
    <dbReference type="eggNOG" id="KOG1295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_740081_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWT9"/>
    <dbReference type="OMA" id="FINWHRY"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD05159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="375" mass="39916" checksum="03649FDC7796C2FE" modified="2012-11-28" version="1">MVNKAPAPRLKLVVRRLPPTLPEATFWSVVEPWTSGALWKRYVQGRPGDNFGAHPVHSRAYVLMPDVASIVAFHTAFDGHLFRSKTGQEFQAVVEFAPVEKTPYRVKEKKDAKQGTIDNDYLSFLAARDSVPEPVEVTVSTPAPPPESTPLLDALRAQASKSKQKQAKKKEKAEKAKNAALASVADAAKNRAPTGGNVVMVAGAGREVYVQDGGAPSEETSKDSKDKKKAPRRKKGKKPEAAAAEAGAGKDDAGEGPSQAQQQQPQGQAQGEKKPKSKPKKKPQEKKPKEEKEKKDGDEGAAPAAGEGEEKKPKSRNRGRGRGGGGGGGGGNKEGGAGGGEAKESGPSKPPKQKKPREPREPKNEVKASEARIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WXR1</accession>
    <name>K1WXR1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000091">
        <property type="protein sequence ID" value="EKD05469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WXR1"/>
    <dbReference type="STRING" id="1220162.K1WXR1"/>
    <dbReference type="eggNOG" id="ENOG502S342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048444_1_0_1"/>
    <dbReference type="InParanoid" id="K1WXR1"/>
    <dbReference type="OMA" id="PRISVHI"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34111" checksum="26D12E5CA1AD1836" modified="2012-11-28" version="1">MAPKAIMAGDEHRFDFPSLILDHKPRSKRTVTLVDLDVDVYGLDEIRKSKLPICAVILSHGRCHSAKMMGTMASGILGELDRLQAESGREKVRDVIVVTLDHRNHGARTRFRNTNLSYDKNPTHLMDMAATVYAGAQDQKFIMDFLPSYLFPRGERTIDSFVPAGVSMGGHSVWRLLRHDPSVRFGIPIISIPSEVLGVNLEERATQYGVSSEELIYPDGVRHYMMGVPPPGAYAGKKILVLSGGKDVSMPIERAEPIIAKISEEADVEWKVDEGAGHKISPDMVRWTADAVWRWTASKKALPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1X4</accession>
    <name>K1V1X4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_07741</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1X4"/>
    <dbReference type="STRING" id="1220162.K1V1X4"/>
    <dbReference type="eggNOG" id="KOG2196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018823_1_0_1"/>
    <dbReference type="InParanoid" id="K1V1X4"/>
    <dbReference type="OMA" id="RFASRHD"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="15">
        <location>
            <begin position="506"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="729" mass="70012" checksum="FE04A42754318945" modified="2012-11-28" version="1">MSGFSGFGQANKPAGGFSFGGASNTNTTNTGGSLFGGGANASSGSSSGGLFGQANNNNNASTPAAGGSTGGLFGNTQSSAPASGGLFGQKPAAPAGGSLFGGGATSTPPASSTPATGGSLFGGGSTTPAAGGGLFGQKPATPAAGSGSTTPSLFGQPAGGAAAPKPAGGLFGSTTPAAGTPPAGTSTPAAGGSLFGAKPADNSGTTTPAKPLFGAPAASTTPSSAPPAGGSLFGAKPATGGSLFGGGANASSSSTPAAPAAPASGGSLFGAKPADNAASGSSTPAAGGGLFGAKPAGSTGTTPAGSSTPAGAPAAGGFSLFGAKPAGSTDAPKTDAAKPAGGLFGAPAASTTTPTDASKPAAGGLFGAPKPAEEKKDGAATPAAPAAPAAGGFSLFGAKPAEKKDEEKKDGTAAAAAPGGGFSLFGAKPAEEKKDGAATPAAPAAGGLFGAPKPAEEKKDGAATPAAGGSLFGSKPATGAATPAATASMAGTGAATPATKPGETATAAPTEGAPSILRGKTLEDIVDGWQRDLDESVKMFDKQAGEVREWDTVLVRNGNQIAALHRQVLDAQANQTALDRNLDYIESQQKQLDNMLTHYEREISTFMDKDTKPLTAKMPADREREKSYALAEDLNKQLDDISRNLSQMIDEVNKLSAGNPGVQQAPDAITAADAQTQLPDDPINQLSAILGAHLRALHSIDANSTKLGAKVDELETRLGQGKGFGSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1V2Z9</accession>
    <name>K1V2Z9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V2Z9"/>
    <dbReference type="STRING" id="1220162.K1V2Z9"/>
    <dbReference type="eggNOG" id="KOG0383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_284567_0_0_1"/>
    <dbReference type="InParanoid" id="K1V2Z9"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
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        <property type="term" value="F:histone binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="HELICASE_CTER"/>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="50"/>
            <end position="199"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="901"/>
            <end position="921"/>
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        <location>
            <begin position="1014"/>
            <end position="1048"/>
        </location>
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            <begin position="248"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
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            <begin position="355"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    </evidence>
    <sequence length="1091" mass="121584" checksum="02299F635A9D0276" modified="2012-11-28" version="1">MGIRSATNMLMELRKTCQHPYLSDPSLERLDLTDEEQHKRLTDASGKLLFLKQLLPELKRRGHRVLLFSQFKIALDRIEDFLWGEGYKYLRLDGNVSQLKRQKDMDRFNDPNSEEFIYLLTTRAGGVGINLATADTVIIFDPDFNPHMDLQAISRSHRYGQTKRVLVFKLMTGIEEQIINKGKKKMVLDHLVVQQMGKETEEGEVDNLILYGVQEIRKEEAMDETAQKWTQQKIEDLIDGAEKEAEDMAKAEAEAEKAAEEAGEGGEGGEKPKKPGETMGFSFARVWETKDSGLKDVEEGDDDVELDDNMWAAFVAEREAAEAERQKAQEAEAGRRRRAAKLAINYSLFDESPRKAKKKDKGKGKKAALVDSDGEEIMYPDAGGDDASDTDYVAPTGPPSDDEDEFDLLPDNTDDLSYELERHYAGIVNGAPHLTKSEKRALREQRARELSLQPPPSAAPQPPSQPAKSSQAVQPAQAQQAVRPPPQVPEQRQSPVFDAVVAEQFISRARLVLRSLHTELNIASKPELRVMWDALCNVGLPLNARFEQYRKLATLADDTRGNSGAPKRYIIRDSGLLVWEFIRSKAFIDQGAMVAHQQQQLVQQQVRPMVPLSQHAPPQPPNQHPNIPYRPYPPAQPGGLPYPAPLPYVPKYRPPPGAIDPFRGRPVQHPPPQYPVQHQMHPQQMHPQAYGWPQHQGQVIPQQVQQTPLLAQRPLPPSVPHQQPPPQHQQAIPPSVHQPQPQAQRPPPPAERPSVNGQPRPTISTAPAPPPATRTPQQASRNSTPISVADSTPGPSSASSRKQRISLSDTSRPSGAQPSTTPNALQLGDSSRFQPNAVDGATDAVDADDAVCFWCGGQHPLDECPGLLSKEQLNEMAKEIEAMEPSEDKDVGLTAITKMREAHARKDRKRKRLLEEENEAKRARQRYSGASGCAICRQNVEHSAAHCPVVRAGPDSIREALKRFPPNDRFHEILTRLLHAQETGVDPSKVQSCVFCDKVCGLTVRECAEKNGSRKLLKHKIRTLEATSEKLGREEAELAKEKKRLAQDTSHAAQGELAGVARKLSELTTKTEGAKLKLDKLYKAYIEWPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1V475</accession>
    <name>K1V475_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAH RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V475"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_1_1"/>
    <dbReference type="InParanoid" id="K1V475"/>
    <dbReference type="OMA" id="HPHQTVE"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001714">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001627">
        <property type="entry name" value="Nuclear DNA helicase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="HA2_WH"/>
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    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="615"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="872"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1415"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1495"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
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        <location>
            <begin position="1424"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1498"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1513"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1568" mass="171376" checksum="5903DBC1DB0B6585" modified="2012-11-28" version="1">MQGRRSARNKQARSQKVPVHPACGSRHQSPTSSPIEAIDATTASYLYLLAHSTPHLVFLPSSFSHYHHHLTHEDVVHQLDPSDDTAPATPVGSAPACNIRRRADRVHATKVERPSYSKISCTALTTGFSLLGLARLTLAPRARAPLGYGHITRFMPSSNATANYHSQSQSQSQSQSRPRSPPPPPSSRSLASRLDPAPTASGHFASSSRAFRSAASAIRPSSSSGPSGSYRSHYDDRSVSSSAAQSQPRKRTHAEPASHGSDAHEHQHKKMRRHPRRPAKNGRGGGGKPPPPPLQQLEPPLLNREEILRRFPVTLKQQWEENPKAPLANYLGGGSGGAQNLGEGGKGFVVTEGSVNGQKVFRPNKKEAEKLAALSAVLQLQANGLAGGSGASAAVANAPGGGETATLSDGSELTYDRARNFMEWYCNKFKFGKPDVEYMSAVQRIPGRKKGGPTTWEAVMSVSGRHIGQGSGQNKKGALIRCYLDVTKYLESCDPGLWAEFVEYAKRDPLNLGMAPHLVFSMSDALCDEVQGLCGDIRHSLLYYNAPPPDAAAHVQQTMPAWSAGRRFHASASELQAKSMALQDRLADYETDPKLEKMRDTRAALPVHTKATDILARIEVNDVTIVMAATGSGKTTQVPQLILDDWINRGDGAKCNIVCTQPRRLAAMSVAERVADERGQPLGREVGYQVRFDVKVPQPDGSITFCTTGIFLKRMQSALGSNANPESVAAMDQVTHVVVDEVHERDVDTDLLLVVLKRLLADRKARRKPIKIVLMSATIDPTLFQRYFADERGLAPVAEVPGRTFPVERHYLDEFLGQLQNIPRNQGGWVFDDKKTIEYLDKELSRDPANFVKTSGITSNELEIPYPLMALTIAHVLRQSDDGHVLVFLPGWDEIKKVADILLDNSGKYPLLGLNFNDASEFSVHYLHSTIPAAEQREVFKPPPPGVRRIILATNIAETSVTIPDVVYVVDSARVKEKRYDPDRHMSSLVSAWVGSSNLGQRAGRAGRHREGEYFGLLSRRRLESLDPHQLVEMKRSDLSNVVMHVKALNLGEVEDVLAQTIEPPEPPRVMAAMDTLRMLGALDGDQNLTSLGRVLLQLPVDAAIGKLCLFGSFFRCLDSALTLAAVLTNRDPFIAPLLVKQEADAVKDSWSPVAFRSDPFAVVAAFNQWSLMDDRGEFGAANRFASDNFLSKPTLLQIKQVKGSLLQSLEQAGIISVSAGGHVPRIGRRTEVPPQLRQHDHSLPLLAALIAMASAPNFAIRTSEKACRTSQDKMVWIHSSSVNSRRREVGGPEEPSASFNPAEKRLYAFGEKTRNVPPGGNPNNALTQIRSVTRLDPLTYMLFGAYELQVASRGLEADGWLPITGNLHALDDLQRLKTLFDTCMLRVFEGVGKALTKGRDERFNARNAVDVRNGSSRIRDREDLDEENENESDDEDSDIDGPNRNASSQIKFQAELARRNARKVEPLSQDEIRELGMLTTDIVRILDAYAAEREGGSTYNSRPNSRPVTPGMGRGGPMGGHMGGAMGSHASMGGMSGPGSGAMTPSGLRPTTPSNPNVYRPPQARRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5A7</accession>
    <name>K1V5A7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5A7"/>
    <dbReference type="STRING" id="1220162.K1V5A7"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117700_1_0_1"/>
    <dbReference type="InParanoid" id="K1V5A7"/>
    <dbReference type="OMA" id="WSALHAP"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="159" mass="17220" checksum="00DAC4E931F33CC9" modified="2012-11-28" version="1">MSAIIKQAGKLRSVSIPGYNHFEKPIRKLIFDYDADSPAQGGIRFLFAFDQADASAYLAKPFAELAAQNPDVEIVVRKLPRGKAAVIRGHYVNGRDKVICVNGLQANQIQNKVAILLESSGAKIRNLKNDTLEAGPGNESARGVWSALHAQSKDGGYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5V0</accession>
    <name>K1V5V0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5V0"/>
    <dbReference type="STRING" id="1220162.K1V5V0"/>
    <dbReference type="eggNOG" id="ENOG502S5NV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431606_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5V0"/>
    <dbReference type="OMA" id="CEAIMSP"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="634" mass="69382" checksum="BF81A798AABCE479" modified="2012-11-28" version="1">MSRPPFAHHRSSFDGPGARPILGEAGPSGSQHHPDARTTSRGGRDRYGSPQRSYGPPPHPQDSQGYLPYPGPPPVHHPGAGQAYRYSQPPPPLASSVPSKTSPRRHNSPDRQRVSPLTTTAPAPSPPVIKRVGGKANVSSACGPCKRAHLACDVARPCKRCVNMNKEDQCEDVPHKKRGRPKVNKPPVTEPYTRSRPGEEGGSATGRRGAAPYDPARSYSSSINSPPSPLGDSGRPSSSRMIPSPPRTAIGSMVPVGQVDAAPPLAGPYPPGPASAPPTAHGVQPIPDLFTIFCTTDFNILRITNACHALTGFHSQEFINLNLNRWVHPADQHVLDSERINLLSVSYLQNSLQSTREVTQAIRSHSERELLTPAIGMTEPYPQVNVRLLRADHGYSYYNVRLHLGGGLGGSLWDPELQGNIYLVVSCLLISDRDAPSDRPPSRRAVMGLPPTAISAMPPPPPHTLPSFSSVAASADILPPRDARDMRDPRDLRGDPRDLAPRIVDRPDPREPRDPRSLRSHRDPRDTHDPRDPRDPHRDYRHSQHYYPRQPWPPGPSRRTPSPPPAYPSRYYPPAYYPSYEQVRREDEWRRRSSAAPPPPGPGPVPPGGHHPPPPSGPPGHPGPPGDYRRTWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6N9</accession>
    <name>K1V6N9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peroxisome biosynthesis protein PAS1 (Peroxin-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="9">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V6N9"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248619_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6N9"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000133">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1253"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1314"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1388"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1427"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1454"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="256"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="524"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1502" mass="162364" checksum="39273144F1FC8B5D" modified="2012-11-28" version="1">MSDPIATLNTLHVEFEDSGSEIPALRRTRRAHVSPDLLKAKKLLAGDWVLLRGTGSPIEDSTVPKPLGWIVAQLWPRIGLDEESEFWFPAAGSKGILKNVTVKLLSEPKPSKGSDETGQKREVEWQRAAVKEALAAVKYVAPGYVVTLSDEETQYVVTEYEVSAKAAAARAATAGALAKELKSLNLSDIPDVYEVEWRTKVSLASDGEGKAGSSGASKSSSYLQLGGLEPQIKQVKALLDLPLRNPEVFTQFGLTPPRGLLLHGPPGTGKTALARAIAASTPGCSCIVVNGPELSSAFHGETEERLRSIFEEARKRSPCIIVLDEVDALCPRRDGGEGGEVERRVVAMLLTLMDGMTSDAKEHVVVVAATNRPNSIDPALRRPGRFDREIEIGIPDAAGRRQILDIMLSKMPNALSAEEIASIAARTHGYVGADLGSLVRESASAAIQRWHTAGGEGSPQLTYADMQATLPTIRPSAMREVFVETPTVRWSDIGGQAEVKQKLRECVEWPLTHADTFARLGVDAPRGVLLYGPPGCSKTMTAKALATESGINFIAVKGPELLNKYVGESERAVREIFRKARAASPSIVFFDEIDALGAARDIGEGHGGVLTSLLNEMDGIEALSGVTVVAATNRPDVLDAALTRPGRLDRILYVGAPDLLTRQEIFKLRMKSMAVDPEVDVAELARITEGCSGAEVASICQDAALATMNEDLNAPFVKKEHLLNSARTVRRRITPEMIEFFEHWRDQSVSLLHGVDLEAECVAVERDGGAVALAHVEGDEARIVVRDHGLLRLLHELVRQSEAAVRPQHRDRRDVPAGLGARLLLPVRQLPPRLRSSHLGQNVANNTSAGVDGDVGQLRPRQGVVQVWKSASGASIKLTVLERVVLRKVKQVGILHAEEVLDLSCQLEEGGEAHSRLPDVHVVAVVVRWTFDVVPVFLDHVLISIELSLIFGIPDHPAKGPAKGPGTFEGRIAFGLLHRRPHHTPCFTMAGLFQPVSALRLLARPGGVAPIRSMRTFSTLRSMSSHVSGHARPRAPYPAAGYFGPSYLPFSSSKAFSFFTPSRFVSSSSPASASAAASASASTDASVPKPEDVRTIPKSLPTWLLGCSALVFGIIVIGGLTRLTESGLSIVEWNPITGVRPPITDAEWDAEWEKYRQSPEGIMLNSEISRAEFKKIFYMEWAHRIAGRTLGLVFVIPAIYYCTRYKLPRGLPTTLLALAGGIGFQGFLGWYMVASGLKEEIIENKEHPRVSQYRLAAHLSAALALYMGMFYTALTLRRDQKLAAQYKQGGAGAAAVDRLTTALSSPAVRRFRGLIGGLTVMAFITIVSGAFVAGLDAGLIYNEFPYMGEGFHPPLDELMDPRYAKKADGSDKWWRNMLENPVTAQFDHRVMAILTFTGLIAQHLIARRPVLRLGANALPKSTQRWSAWTAAAALGQVSLGISTLLYLVPIPLAAAHQAGAVVVLSCLMGLAASMRRPTRAVQAMKQAVNQANAASQAAAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8S8</accession>
    <name>K1V8S8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8S8"/>
    <dbReference type="FunCoup" id="K1V8S8">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8S8"/>
    <dbReference type="eggNOG" id="KOG3974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030651_3_0_1"/>
    <dbReference type="InParanoid" id="K1V8S8"/>
    <dbReference type="OMA" id="WRAAYHN"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="173"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD00400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="336" mass="36248" checksum="01741E9FE9C8B5F7" modified="2012-11-28" version="1">MTGTDKKDKNDAVLQLVQKIIPPLHPTLHKGQAGRVGVLGGSGDYSGAPFFSAFGAMRFGADLAHVICEPEAGNVIKTYAPDLIVHGTLIESKGLKPAIEELKSVMERMHTLVIGPGLGRSEFMQGCAREALKLAKEMDIGIVIDADGLWLINKEPELVKDWPGACRVILTPNIMEFKRLCEALDLSSSNPEEKCAALAKRFGNVVIVQKGGEDRISHGRPLPPAFKVDGDTLVDSTQGGLKRVGGQGDILSGSTGTLLAWGRLWSQGTYESVGSPPDEELKEHVALLAAYGGSNFNRHLSRAGYKKMGRAMVTHDLLELIHPVYDEMFGAQQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V917</accession>
    <name>K1V917_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V917"/>
    <dbReference type="STRING" id="1220162.K1V917"/>
    <dbReference type="eggNOG" id="ENOG502S0K3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076420_3_0_1"/>
    <dbReference type="InParanoid" id="K1V917"/>
    <dbReference type="OMA" id="CGAAYHR"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851934" description="Pali-domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="20580" checksum="FB4F5AE18F220CF0" modified="2012-11-28" version="1">MASPAVPGLFFCFACMVLLLFASVSPPAWNAVNFLKAGTGSGETVYGVFGQCVKGGSCSHRNVCYNLNALGADVVLDSKILHNLSCTLILHPITGALALLAMLMGLIAVCAASRFATILMGLLAILGSIVGLVIFVIDMVLWNVLKNRLTNNNYEAKLGNANWLTLGGVVALLLAACTSMCGACGRFATGRMAGEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9Z3</accession>
    <name>K1V9Z3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9Z3"/>
    <dbReference type="HOGENOM" id="CLU_2428629_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9Z3"/>
    <dbReference type="OrthoDB" id="2576388at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="91" mass="10349" checksum="8730153E4CB19A66" modified="2012-11-28" version="1">MNYCEYYSSYATHAFEPADHHEEHLHETLGAYLAQRHPEKPADLVQFLATRLVSHDRPYGHGGDWFPLNEGDGARRVDDGHRTARLATGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBV2</accession>
    <name>K1VBV2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000315">
        <property type="protein sequence ID" value="EKD01485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBV2"/>
    <dbReference type="FunCoup" id="K1VBV2">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBV2"/>
    <dbReference type="eggNOG" id="KOG4533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048479_0_2_1"/>
    <dbReference type="InParanoid" id="K1VBV2"/>
    <dbReference type="OMA" id="YPENLPW"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="385" mass="42654" checksum="2A894D289D8AFC75" modified="2012-11-28" version="1">MLPTHMSGRKRPVGAYAPLPLSGNWISQLRVRSRLTNLAVLLLLSTLGLSLLYNLKHALFSQTPKYSAKAWNVDLPPELAGRPPSVEATINRDPRMRAVDHLVMVPGHAVWLGTDPERVHRDEDWVLEPMQRGGSVNTYVKHIERAAAVARDDPHALLVFSGGATRSHLTSPLSEASSYHRLAAARGLLRSPAEGTSLPVAQRATTEEYALDSYENLLFSIARFREVTGRWPDKITVVGYGMKRKRFEQLHRGAIRFPAQRFRYIGIDDEGNTSEHYLGELKHGYAPFLFSPAGCRPPLSTKRLDRNPFSRYPSYHSSVPELVPLLEWCPQSTPVGEVGVPTSIGQPGSDRSAGEGEGEGHFGDTAGMQPPKGFRVFEGKVPWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCD3</accession>
    <name>K1VCD3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCD3"/>
    <dbReference type="STRING" id="1220162.K1VCD3"/>
    <dbReference type="eggNOG" id="ENOG502QTNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702459_0_0_1"/>
    <dbReference type="InParanoid" id="K1VCD3"/>
    <dbReference type="OMA" id="NQHHEVM"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="232"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="393" mass="42518" checksum="C5E0588FDA1C2C0D" modified="2012-11-28" version="1">MTSHRVTTYPRDAPSDYLHALWQATLGRHHDAYSIPPSKFHQILNTDNAKVFVAYAGDPEQTPASQSPNSGRESDDRPSSSVARSQAGDSGSGDENQPHGAPLGFAVAYLVKVTASTNPDTKVKGSLGALVVSPDQQGKGIGSALHNAAVSYLEEEVRNSLPPNTDGTLQLGSTFPRIFPGLPDIEYLQPAKDWFGKRGWRIGVPDAIDLYSPLPNDVNYDPFTSEARKHGVEFRHARPADREALMRMEFTEFDSFTKGWPDMFPKMMSAGKYEDIILAVKGGTIIGATFAALPPCPLLDQLVWPSTLGKNCGSIACVGVAKAGRGTGAGVGMVAYAFRDLAEREADGVFIDWVSMKGFYERFGAKQWEAKYCDGTRKVTPAPAQSASEENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDT9</accession>
    <name>K1VDT9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDT9"/>
    <dbReference type="STRING" id="1220162.K1VDT9"/>
    <dbReference type="eggNOG" id="ENOG502S4T5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049365_0_0_1"/>
    <dbReference type="InParanoid" id="K1VDT9"/>
    <dbReference type="OMA" id="GGRWHYP"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC99040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="311" mass="35143" checksum="1634D87FE19E3B64" modified="2012-11-28" version="1">MSYNHYLPQKVDLTPKRHHGFQVVLFFLGWLLPPLVAAQLAGAFDHAVSCRATLCGSPLIPTRFSGALFRSHRALILTAPAVAVRFGIGRDFFINIILTLCGYIPGHGHNFYIQNIRNNSNKARTPKWAIRYGLVNNAERERKARKSQWAKRYDERLPESTFVGQELAEGEEGPNYVPTVPGQQKRRPSEGLWDREDEIYYNEDEAPNQSNWHYPMNFEGTVGDGRSRRNRLNRTASRGSDRWERTRTARADTASSQDSYGSYPPKAATDDDVPVWGKDYGRQRRSSRGSGGSGGNGGRKNDPDAVFNHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE63</accession>
    <name>K1VE63_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE63"/>
    <dbReference type="STRING" id="1220162.K1VE63"/>
    <dbReference type="HOGENOM" id="CLU_381393_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE63"/>
    <dbReference type="OrthoDB" id="29308at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="726" mass="77107" checksum="A5D15FC3A50213FC" modified="2012-11-28" version="1">MALPHYLTSGASSRAHYALLRKLDAAGTLHDADEAIRDEVARCKGVLEGNVSLATGDRGVLRVILSRGVIPPPLSRLNSVLEENEWPGRPGDPTDCAQLEDWKEEAAHACLQSSDVYTGYGLCASSSTQTRRGRGRDARTEIGISISDRTDAAGPRAGTAAREYCAKGALGPHFPADNSPSIRLRTLAALSALAVTGEEYPLSLRQLGKLIRHEQDPGVLTGLLRAFTAALEHGSRELDASRRRKAYDSVFIAAARHADGGPIASAGLRTVTAIVKATRGELKDHVREQAQGLLEQVGEGASLPPPPSVSVSRSVLSSPRSGSQSMQLHSPQRGPQRELSASPRQLMPAHLLEASALAAALFELSGSVDADPLLSHLRNLLVPRAKGKSTRSPSKAEPKGPDANTHVFVLRCLSLLPSAVWQPGLRDEHMSAIMSGTESLDPTVRRACRGNDVAGRTDAAARASEVIEIRSEGLPDQERAKALVSGVTRISQALEGIWVDGVRLLGGLMRVGSAEFCRAVVQAAAQGLQKETEQTLVVALATVACEFPCPGDAPVVVRALMRCLQDLEPSVQEIGMLALGAQLAVIPERERGSLVDESLRALDSLKAKSVKHIAKEAYAEATKSAPASPAMSDSTLGPRKKPESGLRYSYAQPKRTPTPKSPRSPGSASSGTEGKGKSKDRGRSKVLKSPKSPLERAAELADFKAMGRSMLAEDELALDELRLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE78</accession>
    <name>K1VE78_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_08284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE78"/>
    <dbReference type="STRING" id="1220162.K1VE78"/>
    <dbReference type="eggNOG" id="KOG3280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_1_4_1"/>
    <dbReference type="InParanoid" id="K1VE78"/>
    <dbReference type="OMA" id="ETAHNGH"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC97361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="335" mass="37641" checksum="2AFC7C65DDADBEF9" modified="2012-11-28" version="1">MPHEVVPKPRHCRASRDFKSTLYFEVTRGENRPTNDHEARPERTKASEDVLPPTCAPQIITYGKRNTDPSYRSAQSYLFQPGHVYGFPSTPQKVEPPLPPEALLLDQPEKFRPTTNLLPKIFGTLRERYADRPGGYTRIQRFGKRPGDNAPVAILSLVDGPRDLRFEFTARALAREFVANGRTVEGVDQIKRFMADEKAQEFLRPKTRLNLGKVMKYHPERAEEFFELVTDYQPAATSTVTSCTANIQNKLRAEAGAVGHHREAPDSGIKFRPPSSTKPMEGRRALAGERLSGMSISHSGLGLARGALNRRRPNADRSPRFITEKNVPVSNLDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEG1</accession>
    <name>K1VEG1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_03287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEG1"/>
    <dbReference type="FunCoup" id="K1VEG1">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEG1"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="K1VEG1"/>
    <dbReference type="OMA" id="SFFDFDY"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD02395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="370" mass="42348" checksum="2752A0F42EE987CE" modified="2012-11-28" version="1">MTASNIPFNVSEHYKVHEVIGEGASAVHIASGTKVAIKRITPFDHAMFCQRTLREIKLLRHFRHENIIAILDIIAPPSYEQFHEVYLVQSKDWELELTKQELMETDLTQELSDDHCQYFLYQTIRGLKALHSANVLHRDLKPSNLLLNANCDLKICDFGLARSAALPPPDAGPNGGNGFMTEYVATRWYRAPEVMLSFQEYSKAIDVWSVGCILAEMSEFSAAICKLIPVNGKPLFPGRDYHHQLSLILECLGTPTMDDFNEITSPRSKDYLRALPFHRRRDLREMCPKAKPNALDLMRKCLTFSPRKRISVEQALEHPYLEPYHDPSDEPGADPLQPDFFDFENRQSPPSRETLKRLIFSEIQRPLGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF58</accession>
    <name>K1VF58_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF58"/>
    <dbReference type="HOGENOM" id="CLU_681838_0_0_1"/>
    <dbReference type="InParanoid" id="K1VF58"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="404" mass="43243" checksum="29D22D5520257D30" modified="2012-11-28" version="1">MLSTPSAPAPPELSLRYAYDPPSKNVGFTPSARKALQRSFSSTSTSPVLSAHPQPAPTVLPEAVQRSPIRDGALDASHPWLNASDRQNWILRLAMAITANDPIAATKAWRGLAGSLYPAERTGALFTRRDRDGGALLLQTHQRRPRAALADAIEGLTKSSAWLALCATGSKFSRLAVLPNSADAALVIAVEVSDTTKQKGWAIPLNEFLATATDTELDGLWAWDLKPRALDAGAVHTMWTTVRAIGTPGDEAKAAAHGAHVLAHSTPVSTGHRGCRLAPAVPDCAASIPAPVPARLRCSRKSTSTPTSGSERRKRDFTPPPIGKEEERSAAKAYRAEKKRTKVTEWLDALSIDDSETDPEVEEHQCGLERECLLVFVGAGEFEEVMEHRVGSARPHSAGSAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFK1</accession>
    <name>K1VFK1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFK1"/>
    <dbReference type="HOGENOM" id="CLU_821802_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFK1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36426" checksum="ACD58136418E3B76" modified="2012-11-28" version="1">MTASNLSDELQPLPTRKSLDEQGPISLHPDFNQGDVILQSADGVGFCYDIATLGKYSPVFRDLSTLPHSQRSSCRIPILDASSKAVAFMLHVVQHSQEECADAHSSDRASLDKLEDVLEEVLEMIDTFNMDSLTELILEWGRQVDAPPGVMYCLVCLTGVGDKQYWATRCLGLPEEERRGPAFKLLKRYSPEDSVALGRMGIKWRAAVDEFERSFMADEEISHFGSKCADQPCTVYQTFDGDSGQLKWHILRELMPVILGAPLDPEEARLDLVLVCNNNVACRKCARRMSSLAQHTWKLTMAPPPWILHPTHPSLVSEIKARRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFK8</accession>
    <name>K1VFK8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFK8"/>
    <dbReference type="HOGENOM" id="CLU_592101_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFK8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="462" mass="50378" checksum="6451003B664E07BE" modified="2012-11-28" version="1">MIVIAPSWVDDPEDDEPPPFTLKGGQHSIVDMHQAAFVEYNRVADCKWRTFNPHEELVVNSEQPAARLTIAVPVPHKLVVNGRAFFQPAMVYTSEPWGSSLGHLSSSWEAVPLFLRFRKYEAGQIYYIKRAEQSFVLRFECADPGASQTSEHHDCIGFPKLWFAVAGGRRTSVYGMAEFNGALGQIRRNRMTLWRAFGSKEEAEVSLAPICLRTPKPSIDQQFYAVFVDGAKTLYTDKAKFDEHLANSPEAEWQKFDNIKDALVSVRLTQVQSTDAKAWTGGGGAEAAGDNTTSGRVVQTSAEKGLECASNDPSEGTGQAGVRDAEHSEPDGRVSPGSSSSGITTVPLSPLSDDRPLSSGLSVGLDNEPVEEEIVKPAPAENQDEKAVESRVDQAAGSGSAKSAVQPPSELASAEDIEEPEPSSPLLSTLQHEIEWCRSYPATNSNWVPVRFSFDGRIVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFV9</accession>
    <name>K1VFV9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFV9"/>
    <dbReference type="STRING" id="1220162.K1VFV9"/>
    <dbReference type="eggNOG" id="ENOG502S6WI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734009_0_0_1"/>
    <dbReference type="InParanoid" id="K1VFV9"/>
    <dbReference type="OMA" id="ANTHGGW"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="74"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="377" mass="41165" checksum="5B6FFF7E072198DF" modified="2012-11-28" version="1">MHACPSCMSAWSVRSASASGSGYNYDVASPSAFGLGRRYAHAAAMPEEEAGPSRPHRDADYKFPERGARGGPPDPFEILGLERSALPGEIKAKSDYKLALILHPDSSHPAASAEHFATLNKAYKLLSDPAQRRSFLQTGYGWASKSGGDGVSAYDQAFHDAVRHAKQAGAAEWRGRGFRDAEAGSGAWTYARYAEFARASEGMGQGMAGEWAKSHGFYDHRRYGANWQAGANTHGGWHPYMADGNPGQGTGEPIYMSNLRFFALIAAFSGIFAFAQMFRATKSAETHKELLKDKHIQSVTPEDGMRRKRLTNSASQALAEAREEAKKFGHQRREQIKRRVRESNVLKEIDQMEVGGDTGHRRIAPPSNPEPPATAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG51</accession>
    <name>K1VG51_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG51"/>
    <dbReference type="HOGENOM" id="CLU_1157093_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG51"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="26955" checksum="1A9D3C02A0101AD5" modified="2012-11-28" version="1">MTSDEKEPEAPPSSAQQTPVRPRTRRAFSFPVKNALDLIVRPVYDQSTPIIGDKNSPFGLPSNLEEQREAWRTLVPCHNNPRDLNDEIFTVKKISDHAGKKARLAPPRSNRLQIHTSARFFSEMAAKCLALILIVQHGEGSAKQGELDYNWALCREVFGDPFTQYYRNFVDGLRPRINDRRDQWTVHTVSMEAMKAWITTQGPCPVGCQVLPRQPASSKAASSSRHKTAPRAASFSTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG55</accession>
    <name>K1VG55_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG55"/>
    <dbReference type="STRING" id="1220162.K1VG55"/>
    <dbReference type="eggNOG" id="ENOG502S3SQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491066_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG55"/>
    <dbReference type="OrthoDB" id="2594004at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853755" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="292"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="555" mass="59910" checksum="0C1B485354484501" modified="2012-11-28" version="1">MRFALAATVALAASADAFPHMARHLQAHHDMVERAHADLDDRGLLDPIGDFFGNIENGISDIVNGVTGNIKGPTLNDLLGKLTQGRIPSLGDFIGGITNNLKGNGAGDNGNPTSLFDALTKSLTPDGKSLDFSKMDQAEYDSLKNVIGKLDLGDIGSKINLGNLGGIGDGNIDIGPFRQAVPKLGDGIDLGKLNLVAGLQQLGIRGMDFLTQLAGEFKTFNPVTMAQFALQIKQARDEIMRRAEANPEFGGWPSGLLMNEWAKNLSKDKIYDAYKLHRPDDEHGIWGGGEDPDHPYQAPGPDDVGFSMAPETASLLAFGAFTIKGDLWGPKLSIGGKSKYGGGVGLSNHGFFEGDASITRSDAVNGDCFSLNRTRYDIYRSEIAKHGDNGDINEMVCAVSRERAYLDSRSENPSFDFNPLRELVAYAESGFAMEVFRGASKRCTADTIEWFFDKERFPPNWKRRNVPVTMTELMTWGMLFQQIKPSNPGYNIAGQFVPIPKVPGTWTSFVSGGTVKMNACGLTSLFMTLLPVGAATFAIGNGILPVAKPGGFNCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG61</accession>
    <name>K1VG61_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_05869</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000361">
        <property type="protein sequence ID" value="EKC99790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG61"/>
    <dbReference type="FunCoup" id="K1VG61">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG61"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_2_2_1"/>
    <dbReference type="InParanoid" id="K1VG61"/>
    <dbReference type="OMA" id="ICYEGRS"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="196"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="336" mass="36721" checksum="665996D6FC34AF9D" modified="2012-11-28" version="1">MAPQKEQVAILGSGNWGSAIAKIAGINVLKHENEFHSRVPMWVFEEQIDGRNLTDIINEKHVNVKYLPDITLGYNVVAVPDIVETVKDATAIIFVMPHQFLDKVLDDISGHVSPNAKAISLIKGVDVKGADIHIFADVIEKRLGIPCSALSGANIASEVALGRFSETTIGYRNEADGIMWQKVFQTPKFRVQLIDDVTGVSLCGALKNVVAVAAGLSDAAIMRIGLVETTHFCMEFFDDVKPETFLKESAGVADLITSCLGGRNRKCAEAFVKTGKPFDVLEREMLGGQKLQGIHTAKDVHMFLKARNKLGAYPLFDKVYHISWDGMDPTTLTDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG79</accession>
    <name>K1VG79_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_07617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG79"/>
    <dbReference type="STRING" id="1220162.K1VG79"/>
    <dbReference type="HOGENOM" id="CLU_584207_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG79"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="41"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="468" mass="51817" checksum="ED920B40B51FE795" modified="2012-11-28" version="1">MAAVFAVPPQSHNKTNTQRDSDTGAAQSAMSSSGEAHHDHLLIDLAIGIPPQHVKARASFSSADTVVFAGPSASFDPSSSTSYVQGLRDGKVSIEEQRHAGNISHDRIEIDGWVLTEPVVSKAGPSDHGAYLGLGYKSFVGPDNEALVHRLSTKWEKPYYGLYLPPQAFHSSIANSWRRTSPQEGSVRFGQADPRYAKGSVHWLESDSRPDGAWSVQFDGISIDGKIVPMKDYPEATLPEEDSTAFRTTSIRSGSRTNIFIDKTSRKYVLPDAMVDGLMDEVEGAVKWGYGPSNHTIWEVPCEAKNRIELKLGMRDYRLRPDDWMFTTDNRCFSDFAYLSESKTGQTQLGTRFLEAFYTLWNLNPPEVGLMRLDPGLPSPRTEPPPTGHVFNTLIDETLHLTGPIPSLGLARAGFQPAKQSPSTQYCFLVVFGVCASVYCVFRLWRRGKMPFSPRSPRYSPISKELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG93</accession>
    <name>K1VG93_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_07627</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG93"/>
    <dbReference type="FunCoup" id="K1VG93">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VG93"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063085_0_0_1"/>
    <dbReference type="InParanoid" id="K1VG93"/>
    <dbReference type="OMA" id="YFFFSHT"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="177"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="322"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC98081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="382" mass="42471" checksum="67355E39D7487C42" modified="2012-11-28" version="1">MSDAKQPIWLRCEKKPFEHRSALTPTTAKTLLDNGFDVYVERDPQRIFDDEEFEKVGCKIVEHNSWPQAPVEIPIIGLKELPESTEPLPHTHIQFAHCYKQQGGWNDVLRRFAQGKGTLYDLEFLEDPETKRRVAAFGFHAGFAGAAAGCLAYAAQEEDGGKGVLKGLKPYPNETAMVNQCREAIENTKGGLENVKVLVIGALGRCGSGAVDLFRKVGIKEENIVKWDMAETAKGGPFQEILDVDIFVNCIYLSQPIPKFITSEFMAEAGEGRRLSVIVDVSCDTTNPHNPIPVYSINTTFPEPTVEVDTKGVGKRCTVISIDHLPTLLPRESSEQFSTDLLPSLLQFPQRATAPVWTNAEKLFKTKLEEARQEDERLGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGF5</accession>
    <name>K1VGF5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGF5"/>
    <dbReference type="HOGENOM" id="CLU_748390_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGF5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="370" mass="39334" checksum="308F0DCD72299C55" modified="2012-11-28" version="1">MHASAAGKGDNPQAVRDASSTPPPQSAPANTTPSASGNDDIASQGTRNMPDQGYVALTVPSSPLCDSLFSPPTSPRCPTRAATPDDSAVPFLSISDSTPSPEIPSISPLSQSTTTTPFPPAFSSSQPAFLRSTSHRRRTPATSKKIPNTARVRTTTVGELPDMDDRRKRRRSSSTTQAIGLRNPPLSVSIPKRSRLDLSKLKFTKRSDPQTFLDQSRSSSPEVPLAVGLAPSSSAPSDRGSKLRSAAPHKAARAPYPSPALTTTPTSAFSTAGPAYSPDLFCDHDGSPLRFHLDDDSRAEMAMSILDHGGELAPEWDSTFVIRSTNVLSRSKSAVKGNVTSCPLAVSVKWVKESLRAGKLLPTRSYSLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGY6</accession>
    <name>K1VGY6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000255">
        <property type="protein sequence ID" value="EKD03385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGY6"/>
    <dbReference type="HOGENOM" id="CLU_452834_0_0_1"/>
    <dbReference type="InParanoid" id="K1VGY6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003851859" evidence="3">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="514" mass="55590" checksum="6462C1CFB036D929" modified="2012-11-28" version="1">MMTLWAAVLTVLGLASLVAGADDSRPAFSIFLNVTGWSPFMIDTDINWDMNSATGAITGTAKTWNTSTFGGPNILRMTGTRFEPFGIVEDLAPAGTTRTAGNFSYVYRRGLETGDWFTRWSLLEPFPDVGPLANPNNIELGTYTLRMLPKANTTVTISYVVIEVPVLTNAPNELALRDRAQTERAIDAGQVNKAFTIRQFDSDAYEDLIPDRKVEGSLPAAPAEWKIGEDALELLDWTEMTYDVPSNTSIVNVTGPVFYELGGCYARLEPEPWWWNNVIPLAYPTKPAHRAGQTLFFLPTDPAVKYKLVVGSMGVQCIVSGVTTYAYDDALPSQTDATGSPISSSSGGSSVDTSKKLGAGVIVGAVIGAVAGVALLALAGVYWARRRRTPSSQKGNLQSTNNDSQFEETEEVHIIVPFAPLPRPSIDGAQHPQPFHPLGSEGLESASPLLATAKPHLEATAQNQSTAPQVQANAHQVRRAEDMDDALLPPQYREAWSRPHSHSASIEDVTAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHM1</accession>
    <name>K1VHM1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000386">
        <property type="protein sequence ID" value="EKC98601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHM1"/>
    <dbReference type="STRING" id="1220162.K1VHM1"/>
    <dbReference type="eggNOG" id="KOG3991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590773_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHM1"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="202"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="463" mass="48514" checksum="9B8E7A76B3E1A1E7" modified="2012-11-28" version="1">MGWLNKVFGASKDDKRPPPSPTSTSSRPKPKPKPASASGTSTPAAGSHSRSESRTGGNANAANAAPMSEFMASAMAAADAGMTWENQGGYASGARTPRPERVIDETTALSSLTDQEIARLTEGIQADVLKQTAFTLAYLLRILYAPSPKDDAEAALAVINATLPSMQSAGFQADLVEEFMDPLIGAVSSFVSPSPGNEPTEYSLLQLLQDPERSNYIVVALRLITGAYIRTHEERFAAFLFSPVTFEPISPEQFAREEVEPCGKEADNVQITALASALRMPVRVAYLDQSQGDDVWLEVGDNAASEDARPLTLLPGHFDVVTKDNMHAALARQEREGAAAAAQPQGKSPVKSKSPPSSPKKVRPPQEGLHIVASTEAPPAGSSTAGASSSATGAGLAPAEPPSSHSSAQVEPPSPRSNLSPQTTNSPPRSPQPAAARASGEKDAADAPTQDDDDDGRKVTEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI23</accession>
    <name>K1VI23_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI23"/>
    <dbReference type="STRING" id="1220162.K1VI23"/>
    <dbReference type="eggNOG" id="KOG3456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083053_1_0_1"/>
    <dbReference type="InParanoid" id="K1VI23"/>
    <dbReference type="OMA" id="QMIADEP"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="128" mass="13703" checksum="029E10709560667C" modified="2012-11-28" version="1">MLRAVVRPASLVPRAALTRAASSSVPKVQFDPSDKAPKEAAPGQSPNVPSTWSQNQQPKDAAFNNPRFEQVYVPTQPDSLSAMGLVNEQPIVKVQGRRAVCNGGGGPLGHPKIYINLDKPGARVCGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIW5</accession>
    <name>K1VIW5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIW5"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260179_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIW5"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="621"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="819"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1234"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1262"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1317" mass="144326" checksum="F18C81EF2BAE4BA1" modified="2012-11-28" version="1">MTVGAPKGMSFAQRLPGSPRSQAAVLFTLVLCTLTFLLFEYDHLPTRATAWVPERLKPSRPPDLVSTYELPSSAVRNVRHLRKWCAAPDEFEQHFGRANLRRSRGYEALRGDPIKVAAIGGSGHHIYDSETWISLLRDWLAARFPHSKVDAVNGAIPASGSDYFSFCMKLHIPEDADLVVVELGVNDEALPEHETNMENLLRGLLDLPNQPAVMLLEVVAFSQGEMAGGGYRKHLPIAQYYADGSYWHEPDKRHMNSRGHADASRLVQSLLRDAVCEGLQEPDVLFPPKTPMPVERAENESFDELLRGAYGNTPLQRPAHWGDEQRPWSHHVNADPDKGIPESDNWYPGMYTPPPELGRLPRLSALEKWNPHVDHRLAPWHPTCYSARSPDPAYNITPTANEGWHYWFHPDHTDKPFFVAEEPGAKIQFELETKVGLVKLYSLKSKEYGLGNLKCWVEGVEDKAVVVEGFWDRSENIGRFATIAEGLPAGKHKVTCELLKETKDPGGGTNFRLISVMRSICPLITYLSTTATRDALLAFANPTTDPAVSSSSSSVVAGAAGGPGPSCPAGDGGQTPFVFTLGLVHPHCIPEDVSETAFESFESFEEWKARQAAEQTARKPAAVPIDNRTHSTPNANSSSALSSVPESNVAAADPPPPPQTQGKKANRYNYASPDCSARVISSSPATQHASSLLHKSKDRYMLTPCRANEHYVVVELCDEIRISAIEVAVWEFFSGVVRSVRLSVGGEETEDWKPVGEWIGKNVRGVQTFTLPEPTSFHRFVRLDFPSYYGTEYYCPVSQLKVYGLNQMEAFKMEQRRSAEATRDEAAEAAERERQLVQREQERIESERRAAEAKEKEEESKREQELCELEKLVQAQARRGRELDYEEIIQCAPASVASSASLGSSVAAGISSAGSVPSGDGTVTVPAVPNSSAGVTAVSAAASENGSSVSSAAPLPSAQKRDASESIYAHIVRRLSALEGNGTLVARYIDEQARALRGAVSRLEAVQQTLLAARNDAERAHAGADARLLRLSTQVEYLRLAGERDRRAAQAQLRALADELGFERRKSVAQLVILIGIVGLALFSKSATVETLLRPLSERPRKKHGKKLSSGPLAGLVIDVATPRPPLDPEGKGWRDEDDALGRPTSPLSPSQPRRRKGSRPTTPTLAHLKRRALAQRSLSMIHGETEDPVAPAPRSKLRSAHLHPLRRADDDLPPYPVRSPRSPTLRSPGFPQRSPRAALTPTPRRRRFPTQGAEDGDEQWDTSVNGTSASASGASDPNDPASASEASNELASEEEEYNGIGGLHPRLLRHEGSFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK23</accession>
    <name>K1VK23_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK23"/>
    <dbReference type="HOGENOM" id="CLU_2484919_0_0_1"/>
    <dbReference type="InParanoid" id="K1VK23"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="87" mass="9819" checksum="CA271DAFEAB4FD84" modified="2012-11-28" version="1">MCPASTKHRTPRPCCAASRQRDLELAIKLHRRQIAQLKITHREEQCRHEHQAREMEAEIARLALEAALKAISILVNPSRAEAGESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKE4</accession>
    <name>K1VKE4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKE4"/>
    <dbReference type="HOGENOM" id="CLU_1054438_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKE4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="264" mass="27894" checksum="5B72A9D1996ADD8F" modified="2012-11-28" version="1">MARVKAATVSLGGQAVDDNRHRSEPSTSLPHPTAMFKGAITASLGAHASRLTTHPSTATSARSSALCSPRSAPAPAPESLSNVPFNGHIRSLRGDTRHCTLHSEEVRRATTPPEHGTARRLPPSRGRGHPHHALSPGQRWPTGPGRAQGKRGKHKAPPRAREGPGRRRAGGNNERSGSVKVSPGLMPRAVLAPSPPGAAKREVRQTWVVTPIGADAARAQYGPDRVWAQTKNASVKFAVEGERSGDDDDVWGDVAETVLGEVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKI5</accession>
    <name>K1VKI5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">A1Q2_04433</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="AMBO01000322">
        <property type="protein sequence ID" value="EKD01276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKI5"/>
    <dbReference type="FunCoup" id="K1VKI5">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKI5"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="InParanoid" id="K1VKI5"/>
    <dbReference type="OMA" id="PDAVYKC"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="922"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="959"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="959"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EKD01276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1001" mass="108000" checksum="55A5A0931F6FE7A9" modified="2012-11-28" version="1">MTKQHPAAVHALDFPAHTAPAEKVLEALSVDPDTGLSEAEVQKRLTEYGPNRIKPPPKASLGKIFFRQVANAMTVILIGAMAVSFGVMDWISGGVIAALIILNISVGTWTEWEAERIVANLATVGAPEAVVRRSQGTITIKVDEVVPGDIVLLKNGDIVPADGRIVENSNLEADEAFLTGESLPVQKQVEAVEEADCPVGDRIDMVFSGSTVTKGRATVVVTGTGMATEIGKIATALQSKAERTETGWAARWHWVKVKLGLAETSPLQYKLNSLAFCLLAAAIVTAIVVLSTTGFKDIPKSMATYTVAAAVSMLPVSMVAVVSLTLAQASAALSRTHVLVRRMDAIEALAGIDNVCSDKTGTLTVGRMVVRKMWTQGRTFDFETGQDPFEPKGSVTEEKVVVSPGGQLPHELKSLALCTALCNQATIEQGEAGWTANGDPTETALQVAAHKLGLGKPSLTPEYVQIVEHPFDSSVKRMSIAYAHGNDTLCLLKGAAERVLNCCTTWGGQELTSADRDTIMDEVENLASQGLRVLAFADRMADPGVDVTQQSREDFESAPWNFLGLAGIYDPPRAESADAVADCAVAKIKVRMLTGDHPSTATAIALQIGILSRDYPPGAVMTGQQFDALTTSEIDALPDLPTVVARCAPETKVRMVDALHRRHETTAMTGDGVNDSPALKRADVGVAMGTGSDVAKQASRIVLTDDNFASIVRAINKGRNVFKNLAKFLLYLLSGNVGELVVLIIGLAFRDRNNESVFPLSPVAALWINTLTAGPPAMALGLEPSSKDSMRLPPSEYRTIFTREFLADLMFYGWLMGAQALVNFVIVVYGYFPGNLGAHCNEQEAGCGDVFRARATCMATLQMVMLLHAFQCKHATRSIFRIDLRNNPTLLWCVVVLVLSTFPVIYIPVINNKVFLIAPIDWEWGIVFGQIFVYGFASEAYKWAKRKFMRRHPKRDAEEGAARAAMREMEQVNTTGTTGTVDMDKTATNSSMPSTPLEKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKJ0</accession>
    <name>K1VKJ0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_05979</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="AMBO01000365">
        <property type="protein sequence ID" value="EKC99726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKJ0"/>
    <dbReference type="FunCoup" id="K1VKJ0">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKJ0"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_1"/>
    <dbReference type="InParanoid" id="K1VKJ0"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="59"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="410"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC99726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="542" mass="58907" checksum="E258C72BA62033A8" modified="2012-11-28" version="1">MPLTPHSPGSASSFVYNSAGQNLAHNFESRNPMSSSQISWLAGLSTSFDAPTDEQKYLRKTSIIATIGPKVNNVPTLVALADAGMNIVRMNFSHGSYEYHQSVIDNTREADKQLAERPLAIALDTKGPEIRTGLMTNDQDVPIPAGHEFWVTTDPAYKESGTADMIYMDYTNLPKVTAPGKLIYVDDGILSLQVISIDGDKLRVKSLNSGTLSSRKGVNLPKTPVDLPALSEKDKSDLAFGVKNGIDMIFASFIRRADDVREIRKVLGQLGASIKIIVKIENEQGVTNFDEILAEADGVMVARGDLGIEIPASQVFLAQKMMIAKCNVAGKPVICATQMLESMTVSDVANAVLDGADCVMLSGETAKGKYPIEAVKMMAETAYLAESAISYNGLFDQLRQLTPRPTETAETLALSAVAASIEQDAGAIIVLSTSGVSARLISKYRPKCPIICVTRNAATARQLHLSRGVYPVFYPEPRGVPAEKWQIDVDNRIRYGLKVALHLNIIRPEATTNTLRILSVPTDPSDLEIAYIDRNESIHYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLG4</accession>
    <name>K1VLG4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000159">
        <property type="protein sequence ID" value="EKD05020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLG4"/>
    <dbReference type="HOGENOM" id="CLU_456487_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLG4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="598" mass="63928" checksum="62AB89E56C6D07A9" modified="2012-11-28" version="1">MRRSPRIAHLQLIETNDMKTLASVMSAGRYGSAVSVAVWGRVSDYQSVPQPLSTPSISGEDSPLLSSSSVSSILLGGSASVHGRVPYLPPFPSGTSSRRGGSQGGHRGQVQHRASIMSASPRTSSPLSGDPSPLPTPPASSSQLKEEAPPRRNKADQVNMKNTFIPILPSAHWIPFFDKHLGTGCRVNRLHQACDNAGLAIIPSIYTTMLPEEVHGHLEPLVKKALASWYGSNPDFSNFVWRVPVDEASGQTVNTINNGCYAFLGVEHDEDCDEVQDLSLLKDFLRCIWKDGYRDPSLKSFVFLDDVVFDDEITDDTASTNSKICNSMVRLGEPWTMRDASTVERLEAEIGKPYMLRDHQLFTQWRREAQEKEMARVAAEIAAAEKAAAKEAAAAEKAAAKEAAAAAREAAVAERAAVREAVAAAKAAAAAEKAALKEAAAACKAAAEATAKAAKGPTRRGRPRKSNAAAVQEAPSSRSTDRSRPLRPPTRRTSLSPPFPRSRGPRASRTSQRAGVVEPFANPEDIGRGSTSATLQDHCADPTTSTRVGRGSSTGSLSIPASEEGVVPRIAAVVQPPSQPARPLPANGVRHSARLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMZ7</accession>
    <name>K1VMZ7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000088">
        <property type="protein sequence ID" value="EKD05565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMZ7"/>
    <dbReference type="STRING" id="1220162.K1VMZ7"/>
    <dbReference type="eggNOG" id="ENOG502RZAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598771_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMZ7"/>
    <dbReference type="OrthoDB" id="3339358at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50780" checksum="F79E4532CB561112" modified="2012-11-28" version="1">MFPRSPSRAETATLIVPLLPTVLAFFLRLDLSYSPVSTDLTLFLSPWAVPLDFGDLVSRLLQLGLIPYTLPPLPWLWAATSTAALLRAPLGFLLTRSVGWAAPVFFSHRALYEPMTGWGPGLVVWQAMDPVHEWSLAAAAGFALLERRPWTYAVTLGVAMGVLVLRAALPTVQERLVEKPRQGPLRTQLAALALAALVLPLFSLLRPPLRLPFPATSLDVLILSFPRPQNGDIILQKTVDSYAPFLNEMITLNGFTHSTDHAAFAALREQGYNFYVDEDQHPDDEWGHYLHLAEAFRWAEDTLRGEWVMLAEDDFPLCPGAWDVISTVMAELESEREVGRIRAGFIGTGGSGLIMHRSYLPLLQVVLREYSRSASRLPPGVHRRAPDQVVQDCLRGTPGSLCERRDEQRMIISSRIVMDHIGGMATTTEGKALNSDKWRCGWRHAWHGAADVDVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN24</accession>
    <name>K1VN24_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_07633</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VN24">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN24"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_1_0_1"/>
    <dbReference type="InParanoid" id="K1VN24"/>
    <dbReference type="OMA" id="NDWPRAD"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="302"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1293"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1309"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1431"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC98087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1465" mass="155895" checksum="3758B08AF1BAA21A" modified="2012-11-28" version="1">MQALRSTLKAVTRLTASAPIEVITATFIIITLVYFQLLHAIKGSEFFTSLPTSTRPSRPVNFVRLADKSGDAAFAGAGSRASVAHIPAPNENWIPLSSSDFRRAVEANALEGGFVLSQDEGGNTAGKRAAIAFVKQLTVSREDGTDADREAWRRWLLNDVTVPSPSGHEVSYADLCFGPKCGDAPKFEDHPLNADLSTLTLILRAPTPDSPTLSYLNRLAHLPPVPLPGTNATVSVVPGESGSSSWGGFFPNIDGANLFSGLAPAQSADTNFAVRKVRWIATAARVLVMRFWTLAKNADSADVFVVLLGYVLMHATFAHLFIDMRKLGSNFWLPFVTLISSTFAFMVSLLCAYLLNVPIDPIVLSEAVPFLVITVSFDKPLRLAHAVFEHPDISPVAASPELTPIDGFEDDAPKNGLDLHALHRELAPIERLQKLADGKGIRWVAPVAASKIVSDAVAQSGLSIVRDYALEIIVLSMGAASGIGGLREFCYLAAILMAVDCVFLFTFYVAILSVLVEVHRIKLIRGNRRAKAALKRSASNLSLANTPKDSPSPTKTSFFGGGKAPKADGQPENPVVRLKLFLIIAFVVLHVLNLCTTLTEQTALKRATTHIISSVPRVDSRSTNLSTILDTLYKAQPPHTDMIIQIVNPTHLVMSYTNRSASQRIERIDSFMSEWSMLVGDPVLSKWIVVALFVSILLNGYLLKGIASNSIGGKGPVAAAAAALVGVFEAAEVNGQPRRTRAPSMLERFRMPSVPGNGHKSRASVATVAGDKTPTNSHKVNGHVNGQANGSANGLANGHANPVVSNGIPPVTIAEPVVSVDSAPPSGGLQMTFGRRSLEECVDIFAGGVGANNLSDEEVILLVQKGKIAPYALEKQLKDCERAVRIRRAVISRAALNQTLETSLLPMNDYDYKMVMGACCENVIGYMPLPVGIAGPLNIDGQLLHIPMATTEGTLVASTSRGCKALNAGGGVTTVLTQDAMTRGPAIDFPSVREAAEAKVWIDSDEGFSTIRDAFNSTSRFARLQRLKTAMAGRTLYVRFATSTGDAMGMNMISKGTEKALEVLQRRYPNMDVLALSGNYCTDKKPAAINWIEGRGKSVVAEGIVPGHVVRTVLKTTVEEMCNLNKKKNLIGSAMAGSIGGFNAHAANILTAIFIATGQDPAQNVESSMCMTLMEPCNNGEDLLVTCSMPSIECGTVGGGTILPPQRAMLEFLGIAGAHATSPGANSQRLARIISAAVMAGELSLMAALAAGHLIKAHMKHNRSVPVTPGTVTPFTGMTPAVNEERLLKGTLLNASAKGRPGSSEEEPASEKEETDVKKEETGEAEREPKDVEHDESSDLLSDLPQSSNPPEPPSKVAPVPKAETAPSTPPRPPQPLRASSSPGLMSPASQLHGLSGISGSPTTPFSPGGLGLRLQRSISDMSAHHIIFNRSPSQATTPSHSRSPSVASVQLKNTTLVEDDLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNJ0</accession>
    <name>K1VNJ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNJ0"/>
    <dbReference type="HOGENOM" id="CLU_1705495_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNJ0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="154" mass="16880" checksum="6E78245E0508F40E" modified="2012-11-28" version="1">MQTLPSSHTLKRALLPRSEKMPSRFQSTRVRQSLSFPGDVVPSPTAGERSGASLFGLRMLRRTVMAASEARKHKRAAYRTPCRARCLGFGRGPTAHQGDGTGHDVDNSVRSPDVPEERGGQSSAYLHERHGLPGIVLSSDYLQSESAGWVRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNS3</accession>
    <name>K1VNS3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_03418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNS3"/>
    <dbReference type="FunCoup" id="K1VNS3">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNS3"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_7_2_1"/>
    <dbReference type="InParanoid" id="K1VNS3"/>
    <dbReference type="OMA" id="WMENTAG"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="174"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD02271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="327" mass="36057" checksum="E2CF782C50A5F9B8" modified="2012-11-28" version="1">MSLRLFPGLLGRISAAARCTPTPTPARTLQSARGFASRSGPRLDSKQFFTPLRRPAAPGASGAAGSGKVGWKGLGVGGLFKRAFGTTKPTQIIRTQWTQNQRRGGPRPTWWRKLQWRLNSIPPQYLTITILAINIAVFLGWQYAINTYERFGDPSAYYTMLKNFILNVPNMQAGRIWVLITSCFSHMTTTHILVNSIGLWFAGPAVASILGTSGYLLFYLGAGIFSALTSLWWQNRKPGWTIGSEGASGAIYGCMAFFGTMFPKATFLLFFVIPMPAWALLSGVFVWDAWRMVYDPASKIDGAGHIGGIIAGVVTALVCKRRYRRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNV5</accession>
    <name>K1VNV5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_03362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNV5"/>
    <dbReference type="FunCoup" id="K1VNV5">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VNV5"/>
    <dbReference type="eggNOG" id="KOG3326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103054_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNV5"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="148" mass="17301" checksum="499152CC7B0B65EB" modified="2012-11-28" version="1">MLSRRLLTLASSSSSRVRALHVSRVVLAESDPFPLPFDPALLAQQQRPRHDQAEAEMAQWQAIKPIERVGEDDNKMRARLVYQTRKRGMLENDLLLSTFAKNELPSMTREQMEEFDKLLDENDWDVFYWATEKKEAPERWAKTELLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNV7</accession>
    <name>K1VNV7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_07386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNV7"/>
    <dbReference type="STRING" id="1220162.K1VNV7"/>
    <dbReference type="HOGENOM" id="CLU_059975_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNV7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="274" mass="30897" checksum="50B4EF6D43A49F20" modified="2012-11-28" version="1">MSDSEAAFNWLQSNLPSVLSKFGTEVDLSCWVTGGDSAGAAIAAWGSLRLEPMPTAFVSVYGMSTCSDPYFLPPGRDPPLNKVVNSLQAIQAFCDERDPAKAEFCGVFKHELPPNLTLGQLQAYWGLPSDWEPPKTAQMRIDMMTYEYERRLMSVIGGRRETFNSDEEWMESLKPLDVVRQVHERKRFPPAFMVHGEKDWTVPTYHTRNLEAALRAEGLPCRAMYLPGELHNFDLKIAGPQDPEWDTVITPLLDFVDSYVYGDAAERSPKESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPH9</accession>
    <name>K1VPH9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000317">
        <property type="protein sequence ID" value="EKD01387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPH9"/>
    <dbReference type="STRING" id="1220162.K1VPH9"/>
    <dbReference type="eggNOG" id="ENOG502RUZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418080_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPH9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="656" mass="72329" checksum="B2979088A9784817" modified="2012-11-28" version="1">MLVGMVLWQSQRSTVFADELASAIQGLTDDDRLHCSIGSASTEERFELLERLNDYADGLGEGATSHSQFFAPTPPPGSVPVTETLKLYGRWPKEEDRLVDEWLPRLDAFRNIAQELEAREQCDRSANTECSTNSPIGVFYVWAVSCLKYDSRDPLTGLPFNLSDTGSPLKPTLLAHKIHKAPLDLGQLKKVPTQLSHFDDSRRNARVEAWGVNKFLRSYRLPAVEAFLDGLLPMLRQRLQRLQAHGLLIGVTMPQHVVRLSHHVDTRLRLSHSDFASLFDECGAMTERDVRKLEGVARATGDVQRLWRDELRKWQMENDENVDNVLKLNCSTRNLRTILWVEHHPIDLVFDANAFLRKKFGGRSGRQLSLRTFCQYQNTPGRRPLDQLIPEQDREVRVDPAPHTVDAAAAIPRARDRIVTGSLNPLEVQLRESERIAVREERPQRQILLANVVEPAAAEPIAVEPVVAEPIAVEPAAAEPIAVEPVVAEPIAVEPVVAEPIAVEPVAAEPMFGEPAAAEPFVAEPIVAEPAQHAVAERVTVAPAAVEPIGVTAGRVPAEAELPVVRPNVPVAGPGHVNRAFQEISSIERRLRRADPDAEPAPLVTPVSALADSSYPQRLAWQLPAVQALAGIINASAPAEEDDDEGDESFMGVAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPW0</accession>
    <name>K1VPW0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPW0"/>
    <dbReference type="STRING" id="1220162.K1VPW0"/>
    <dbReference type="eggNOG" id="ENOG502SCS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180929_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPW0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26336" checksum="4448FBAB84166AAC" modified="2012-11-28" version="1">MSSTDTPMDGDKVVLSVASSHNGRVNGKHWKAGKGATKRTTMPKGQRTPYERRMEKEKERKAIKQVEQEMKDEAREERESVQGPWLYSSLEAHKLIATDGKLTSRRANIIRERRAKQEEKARLEAMAEKMSVKKMQRMKKVSSIYARDGEAGACRSVPGVPGVPECVGARCNRTLEPGSDQAVERGGLLFPPIPLQHRQSARLLLPAHSGHYPQLPLLSTELTFQRQGRTKKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPW3</accession>
    <name>K1VPW3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000314">
        <property type="protein sequence ID" value="EKD01497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPW3"/>
    <dbReference type="STRING" id="1220162.K1VPW3"/>
    <dbReference type="eggNOG" id="KOG4464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397944_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPW3"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="595" mass="65854" checksum="96CF1A35FC04D495" modified="2012-11-28" version="1">MEYLSADGYMRLENRGRNPEVETELLKIVSALPTQIKPEDRTALLRAILGDLSCKAVWRRWSQDLKVLGRNPIGSEVLVEDSSLSTLAYHTGLPFESSTNQPATPPALEAQRALANTLVLHAPARKRLATMGGPQAIGRALAEPLPTDRLFLVCRIGFLVTADGIGVKDMVEGADIVNRLVYPIPINYDALSELLKLTGNVVRIYPSKIGEDWSDRLTPETVPIWTSSGGPRKWPGLRLLPKRSRSPLRAEDSGSGSSDSSSEGMPRKRDDAFPLRLLGILSEFVRHHMPGCVEPNPELQLEEILPPVLLLGASTAQGSEVMRKAYRNTLFPPNLRARHDPPPSQFDRIPELLQLGGRVPMGASELCDEVGYGNVAGLMFRKGMFRPPPAKIKELDSPRPSVSSTKSMRHRRGDSRSKSISRRGSASQSRRGSESMPASRRGSEHTSAPPSAFDERFANLPPSPAPPAPSSAGPGPFDDRYGLNPITGLRHTADDFKNPFEGMSDAEKEREAEKMFVLFDRLKSNPVVKAGVPQPDGSEKPIHDEIRDQMVGEQGERWERLEAEKEKERIRRQDEQDEQEALNEMAAYRKRMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ75</accession>
    <name>K1VQ75_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycerone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_06828</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ75"/>
    <dbReference type="STRING" id="1220162.K1VQ75"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="InParanoid" id="K1VQ75"/>
    <dbReference type="OMA" id="TLGNMSG"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase, L subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="12">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="11">
        <location>
            <begin position="273"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC98857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="476" mass="49985" checksum="233A58CC8AF09333" modified="2012-11-28" version="1">MAQSQGIPNVELVVVGDDVSVPRSRGKMVGRRCLAGITMVCKIMGAASEEDASFEDLLKLGRSLASNIGSVCTALEHCHVPGRSEFASIPEGRIEIGLGLHNETGVMNVPLPSPESLIETMLDLILNQDDPERAFVPFAPEDVTVLMVNNQGGLSPLELGAVVDETLKQLKERGVEPERVLSGVFMGSMNMPGMSLSVMNVSNVAKDTGLSVDKIISLLDAPHTAPAWPATAGVYPLPEKLRNRPLSERLTEISPEETKESAPKGPALKADPELIRQILQKAAEDVVALEPELTHWDTLVGDGDCGETCAAGARGVLSHLDTLCASDLVSLFRELTEVIDDAMGGTLGAIFSIFLAGLTTSTMAAARQSPQPAVTPQLLGQLAMGGLETLQARTAARVGHRTVMDSLIPFAETLANSGDVKAAAQAARDGGEGTARLTAKLGRAAYVGDREDVDMPPDPGAMAFVAVAEAIAACSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQI5</accession>
    <name>K1VQI5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G-protein alpha-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_04003</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in the mating pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQI5"/>
    <dbReference type="FunCoup" id="K1VQI5">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VQI5"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_0_1_1"/>
    <dbReference type="InParanoid" id="K1VQI5"/>
    <dbReference type="OMA" id="FMAIQAM"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="251"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="337"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD01632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="420" mass="45909" checksum="A532981570E08C8E" modified="2012-11-28" version="1">MGGCMSSEATKVENRRTSDPKKPVAAAAAAPTTAPPAQAQAGAATTDASAAANGTTAAVAPAAAGPNGTNSATQGLSAALAQAPEAAGAGNKTGDKSNSIDRQLEDDSKKFKKECKLLLLGKSTIVKQMKIIHQNGYTQDELMQFKNIVHKNVLDSAQALVMAMRKIGVDPEDPTNWTHADRIVEYKADTENGPIPAEIFVAIEALWHDPMIPVVMDRSSEFYLMDSATYFFANIRRIAAPDYIPNEADVLRARTKTTGISETRFNMGQLSIHMFDVGGQRSFEAVTSIIFCVALSEYDQVLLEENGQNRMQESLVLFESVINSRWFLRTSVILFLNKIDVFKQKLPKVPLVNYFPEYTGGADINKAAKYILWRFTQTNRARLSVYPHLTQATDTSNIRLVFAAVKETILQNALRDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQS0</accession>
    <name>K1VQS0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQS0"/>
    <dbReference type="HOGENOM" id="CLU_2980759_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQS0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="58" mass="6227" checksum="33EC3F4A77CABB18" modified="2012-11-28" version="1">MFGLRWLTCCFAQNTPLLAPPAPTKATTQPTATGKPLAALSALLGYGYKTETRKVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR27</accession>
    <name>K1VR27_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">A1Q2_03773</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000305">
        <property type="protein sequence ID" value="EKD01927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VR27">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VR27"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="InParanoid" id="K1VR27"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="21">
        <location>
            <begin position="48"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="20">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="453"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="22">
        <location>
            <begin position="678"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="866"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EKD01927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1334" mass="142212" checksum="E307455071DCAC11" modified="2012-11-28" version="1">MLVLTGSSAITPTRRAALLKALQGADSGITSVDAVHLHLVNATSPQTEADLASGAERQILDRLLAYGDDERLESTAAYLSGNKEGVTAVYVLPRAGTISPWSSKATDIAKLCRLGQHVNRIERGALYLLGGSNIQLDKLEKQLHLIHDRMTQVVSTSLPAAQDVFPPAAPQPDPLVTVPILGAKDPKAVLEEANARLGLALSDTEIPYLVDSFLAAGRNPTDAELFMFAQVNSEHCRHKIFNAAWNIDGADKENSLFGMIRNTEKQCNSNGTLSAYHDNAAILEGFTAPRFAVADNKGTYGAKEEPMPILIKVETHNHPTAVSPYPGAATGSGGEIRDEGATGRGSRPKAGLAGFTVSDLLIPGFEQAWESDIGRPGHIASALDIMIEAPLGAAAFNNEFGRPALGGYFRTFLMEVPSADGSPEWRGYHKPIMIAGGLGTVRPEYALKEKITPGAKVIVLGGPGMLIGLGGGAASSMASGASSADLDFASVQRENPEMQRRCQQVIDACVNRPQSEGGNPIQSIHDVGAGGLSNALPELVHDAGLGAVFEIRDVLVDDPKMSPMEIWCNESQERYVLAVAPKDLPVFEEMCRRERCPFAVVGTATEEQRLVVTDRLLGENAIDIDMGVLFGKPPRMHRKAETVHPKREAFDATLKQYSPSATLTEAADRVLHVPSVGSKGFLITIGDRSISGLVTRDQMVGPWQVPVADVAVTRSSFGFDVKVGEAMAMGERTPLALLSAGASARMAVAEALTNLVAASVPDMGKTKLSANWMSAASAPGEGSRLYEAVQAIGMELCPALGVGIPVGKDSMSMSMRWGDKSVTAPLSLIVTAFAPTDNVSATWTPQLRTDVGETTLVFADLAQGKQRLGGSALAQAYKALGSEAPDVEDASELKAFFTAVSELHKGQTVLAYHDRSDGGLFTAVAEMAFAGRSGVELTLDGYSTGDAAAALFNEELGAVFQVRNADLASFTAAFTAAGFPTQRLHALGRVLGQGEQKLSIIQNGAEIFASTRGQLQQAWAETSYRMQSLRDAPLGAKEEFDAILRDDDKGILYDVKFDFLTSPPPGREGAPKVAILREQGVNGHIEMAWAFHAAGFESVDVHMSDIISGRVGLSQFAGLAACGGFSYGDVLGAGRGWANSVLLNPKAREEFEAFFKRPDTFALGVCNGCQFFAQLRDLIPGVSAWPEFKTNRSERFEGRVCSVTITPEAARNVLLRGMEGSTLPVAVAHGEGRAAFDAKGSLDQLEKEGLVPVRYVDAQGKVTQEYPLNPNDSPHGISAVQSPDGRVLAIMPHPERVVAAESNSWFPPQLGEAWKGKGPWFRLFQNAYEFAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRZ4</accession>
    <name>K1VRZ4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRZ4"/>
    <dbReference type="STRING" id="1220162.K1VRZ4"/>
    <dbReference type="eggNOG" id="ENOG502SMWD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847349_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRZ4"/>
    <dbReference type="OMA" id="APFKHEK"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="28206" checksum="4AD8565782FCD86E" modified="2012-11-28" version="1">MSPKQVVVAETPAPVAAPVVPEPTEVKVEGEAVATEAAVAPEAPKAKDAAAAEVAKTEEKAKAAKEKVKAEGKGFFAKLFGKKDKKAAKPAAAKTTAEAPKAEEPVAEAAAAPAAEAAPAAEAAPVAAAEVEAPKPVEAAAEPVAAPVVEAPAAPAAEPVTTPTAEEPSVVAKGEQAAKDAEAAVEKEATKAVKATRRLSARFTGFFKHKDASPKKEVPPSTPSPETEAAAAAPAAAEEAAPVAAVETPAAVTEAAPKIEEPAPTEPIQIEATSAPPAAPAVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSL6</accession>
    <name>K1VSL6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">GTP binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_02149</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSL6"/>
    <dbReference type="FunCoup" id="K1VSL6">
        <property type="interactions" value="827"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSL6"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSL6"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="70"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="AARP2CN" evidence="13">
        <location>
            <begin position="210"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="14">
        <location>
            <begin position="659"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD03566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126992" checksum="C2BCCC53AF9612BA" modified="2012-11-28" version="1">MEKPHKAHHKPSAGSKLDKKDKAQGVDRRHAHGYNPKKRLHVPLVNRNPEERKVTQEKGQGMDEGRMPPPPIVVGIVGPPGVGKTTLLRSLVRRYTKHNLNDPQGPITVVSGKTRRITFVECGNDLNSMIDLGKVVDLVLLMIDGSFGFEMAHGFPKVIGLLTHLDLIKKQSTLKDTKKRLKHRFWTEIYQGAKLFSLSGVINGRYPDAEINLLTRFISVVKFRPLVFRNQHPYLLADRLQDLTPREEVRQNPKMDRTITLYGYVRGPNLPARNAKIHIPGAGDLEVKEVERLTDPCPLPTLESERRRRMGEKAKLIHAPMSDVGGVMYDKDAVYVNVLGSFSKDGDQPKGEGERMVIEMQDAQATLAEGMEKSQIRLFDSSSAPLTVDSDGKRKRRAAAPRSGGPMLGAASDDDEDFDDEFDEDDGGARIEEIDDDDEQEKDVAYASSDSENDLDMVTGFEQDGKRINLSDDEYDGSEPEADFGEGSEDDDEDDEDDEDVPQWKRNLADRAATGFAERMRRRRDLMSMIYGDELSPEEIAAGKTRPSSADAESSAMAMSNDGFLRVQGGDNAGDEGDAIKEPVDVKALEERWSDETVLDGLQKMFISGAMGEETAEGLPYEEEGDDFEDLEGGDGDDEDGEDGENVPYVGMKPDGSGQVDHISAREEAMARKKKALAAKFDEQYDDEDEESGMDFYDQQKAEMARQRALNESEFEGMDIDARAQIEGYRSGMYVRLEIDNVPCELVENFDPKFPIIVGGLLAEEERFGYVTVRIKRHRWFTKTLKTNDPLIFSLGWRRFQSLPIYHLDDHSIRNRMLKYTPEHMHCFATFYGPVSAPNTGLAAFNSLTNDAPGFRVSATGVVLDVDRSTKIVKKLKLTGTPYKIFKNTAFIKDMFNSALEVAKFEGANIRTVSGVRGQIKKALAKPEGAYRATFEDKILMSDIVFLRAWYSIEPKKLYNPVTSLLLADKKGWKGMRLTGQIRREEGVDTPLDPNSAYRTVERSTRRFNALKIPRKLQADLPYASKPKVMNAQKKPTYLQSRAVVMGDEEKKAVALLQQIQSLKKDKVARRKEKQEERRKGHREKVEASEERKAEKIREERREKARQEAIKKAHLENGGGAGGGKKRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VT72</accession>
    <name>K1VT72_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_05852</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VT72"/>
    <dbReference type="FunCoup" id="K1VT72">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VT72"/>
    <dbReference type="eggNOG" id="KOG0026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_0_1_1"/>
    <dbReference type="InParanoid" id="K1VT72"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="12">
        <location>
            <begin position="284"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="12">
        <location>
            <begin position="427"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKC99887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="545" mass="58947" checksum="0BFCCA26516C8A72" modified="2012-11-28" version="1">MVPPLPRTVIVDYYDSFPSPVAIAEIRATFQREVIPNTDCVILSPGPGRPDHPAAHPVPILGVCLGHQAIGVAFGGKTPKITHGHVVRVVPVTPPKGLFASPVMGSKPFEAVVYNSLCINPSTVPDELEVTAWSDPQNGSEPTIQGLMHKELPIWGVQYHPESISSTHGTELLHAFLDKVHEYHGQPPVFPRLERQLVAACTYRVASSAAPTRAASPAPSPTSPTKAEAPQYALEEESFGSLGQDRDTAEVYERMVRSDKNRIGEIWLDGKSCDLLLPLSGARHVCVGESYELNQTTSFLASLKDDPYPTYLRLRTFNPAYYSAFIHFPTLPTPKGKGLAVISSSPERFLQITGGEIEMRPIKGTAPRVRPGQCVCADGRGCDGKEPGSAACTTEGRRVDEQRGKELSEDLKERAENLMLIALESYGVHNLVTTVRGRLAPHIGPVEATKRCFPPGSMTGAPKLRTVQLLDGFEAGYPRGIYSGALGYFSLCGSSDLSVVIRTMVLEGEDLSIGAGGAITWLSDRAEEWKEVLTKVQSVVGPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTE9</accession>
    <name>K1VTE9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_05731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000354">
        <property type="protein sequence ID" value="EKC99967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTE9"/>
    <dbReference type="STRING" id="1220162.K1VTE9"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="K1VTE9"/>
    <dbReference type="OMA" id="FMYPETR"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF52">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC99967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="526" mass="58222" checksum="A78E0EE80A316BC6" modified="2012-11-28" version="1">MTSANHLLSLPNNTHRHWWRDKSLRQNVLHCAGCCLCVFYLGYDQALLAALQAIPEWNAYFDTPTGTKLGLIASSLYFPGLIASFFGSWVSMRYGRKPTVGIGSALIIIGTIVNALAKNTGVFCGGRVLIGAGGAITKIAHPRLRSFIASSYYGWFFLGSALSSWLCLAGLYIGNDWAWRMPCMFQLFAPVLVIAITSTGPESPRFLINKGRNEQALNVLAKYHANGKVDDPLVQAEYGEICAALEAEGEEHKSAWTDLVRTKGNRRRIVMAILMACGTNWTGSGLLGYYLTPILASVGIKDPKQTTSLNGGLALWNLLSCELAATQVNRISRRVSFFISGIGMISAIAIVTGMSATFAAGKQSFGIPTVPFIFIFFFFYDIAWMALPFHYCTEIMPFHLRTKGLAIFTAVQTFANGFNQFVNPIAFKAIAWKYYILYIAINAAFLVYFYFFLIDSRGMSLEEITLLFDYPRKQARQRAAEDMHARVQARIEEKARVESEKDSEKGDIVMVEDVAELGRDSGKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUE3</accession>
    <name>K1VUE3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUE3"/>
    <dbReference type="STRING" id="1220162.K1VUE3"/>
    <dbReference type="eggNOG" id="ENOG502SCUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1918550_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUE3"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="136" mass="14716" checksum="EF2FE3EDA7DBFE47" modified="2012-11-28" version="1">MAHLLSKTLDPLLGVFTGFLAYYLHETNPRTAPPPGHSMKELIQWQWEHSKRKRDEAAAAASAGENAELDAVRKEFEAAAAPVVASSAVGQQGQQQGQQQGQQQGQQTQQTQAQSQPQGQVAQAVAQSKKTEDRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUI1</accession>
    <name>K1VUI1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUI1"/>
    <dbReference type="FunCoup" id="K1VUI1">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUI1"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556896_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUI1"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="102"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD04131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="490" mass="53155" checksum="8BC1722F7E5302AC" modified="2012-11-28" version="1">MPPTPNIRRNPVSTVPTVAALYRLFAAVPELAKRGLQTQLEEEGGGEDEPGPEKVVKLLIATGLVLLGGVFAGERAAATKVLRLLRRGRHWVLVVLLLGNVICVRYGLAIGGACAPMVHALMVLFAPVAWPIAKLLDWVLGHDAGHTYKKAELKSFLQFHREGEEPLRDDEEIMTPIEDCLTLSSDKILDHEAVDEILLSGFSRIPVYEAGQPDNFIGMLLVKGPVSKFKLLPLPEATPDLNCFQALDYFQTGRAHLLLISETPGRRGGAIVEDLIEEIIGEEIYQDNHSKRKAQRKATANIMRGIIERQRVINAFSRRPSSPHPATRSPREGLLVRLDDEAPLHSEPTTIQEANSRVGSPEVNLLLPPSTGGVEAIVEAVDEDGKPTAEQHGTPVKTPSPLGEHGDGTEDLNGSESSEDAKAADTKDASKSDSKDDSKDAAKDDAKDVSKDDSKDDSKCTKDANGNGDKSNGKGHNEPKRGRNKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUT5</accession>
    <name>K1VUT5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUT5"/>
    <dbReference type="HOGENOM" id="CLU_1050488_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUT5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="265" mass="31210" checksum="C4BBEB552F21D5CE" modified="2012-11-28" version="1">MGILGYFFHLPRPDIRENTTLFKHAGKEPFLVRRPGPNAHTEILGVKPFWWRKDRTVWRKKKMPWGNDPALFNNHSNGWPEVPAVRRLTAQEWLARPTNPPTKDKWGNVWYDASEDIHGIPIACGLWLMWHPFVDWKEFDYVVQLFAMELAGRRMPELHYIPFEDIHEAIRAMDLEAWGPRWAKAADHSVDVQEIWRRILIVIRKFDRPDVVACSAFASAFRGFPMKTQRQAMMHCLRTAQRQRDITEDTGNHYIWMDPGNGFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV36</accession>
    <name>K1VV36_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_05106</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV36"/>
    <dbReference type="FunCoup" id="K1VV36">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VV36"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="InParanoid" id="K1VV36"/>
    <dbReference type="OMA" id="LRQEWVW"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="239"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="446"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD00618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="604" mass="65759" checksum="00F2115DEF9E1D0D" modified="2012-11-28" version="1">MSTTKPANGTANGTANGSASGTIPFADYMIARFKQAGVKQIFGVPGDYQLEMLDYFERDPDVQWVGNANELGAAYAADGYARVRGGLAVCVTTFGVGELSALGGIGGALAERLPVVHLVGSPRSPLQHTNALVHHTVNEPGQYQKFTKMSEPISAATCVLINVKEDSDHSLGDAFDAAITTCIEEGKPVYIDVPLDYNHKQVSKAALDKPLPKFGAPKKGIRRNLTDPPLGQVMDEVVESILDKFTAAKNPVVLADLYAERYGMRSVVRELVEKTGMRAFCSPTSKTLLDEQASSYAGSYGGTTSLAPVSKEFEAADFVLYIGAMKSDTNTGRFTTKVHGAVEMYIDRCVIGTAEYRDIDMRELVPRLLPFIAEAAKSKGLKVKQESVEDKVKAGTVLAYKTGVEGDVISQEWFWPRMAAWFQDTDVLLGEMGTAAFGMLPLALPTNAQYHSQCMWGAIGWSVGAALGAALAAREIDPAKRTLLFVGDGSLQLTAQEIGTMVRRGLCPHIFVINNDGYEIERLIHGPDAKYNDIANWDYTMLLPLFAGRTGMKHETHSVKTQEELQKLLEDKEFAKPDRIRVIEVFIPKGDAPHVLAQILQKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV58</accession>
    <name>K1VV58_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000255">
        <property type="protein sequence ID" value="EKD03382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV58"/>
    <dbReference type="FunCoup" id="K1VV58">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VV58"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029722_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV58"/>
    <dbReference type="OMA" id="WNYLDAP"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55419" checksum="B158743FEA486B68" modified="2012-11-28" version="1">MSTMTLPPIDPLASQAFVDEAGAPATLPDVGDGGEQSKLKVLMGLLKNPRAARPGCTLRLETDSRLVGVKDVATLRLSLPASLLEPIPNLEYWQYADRADVFAAIGDADDEFGRMLGVLRFLFSKDLKFVRARLGKPYNSALGEHFRCAWRVPPLHLDKRGEPIVRTHIHVPLPNEPAYGGQGGSGWSTPVLAPENGGFSSEVSSLKSSPGLMARKDKLTAPSQASFDMSALRQAIPGPGDEILPREPDAGVKDSEKTTVVFLCEQTSHHPPVSTYYYGCPEKGIEAVGVDQIVAKVSFPSIRLGPGPQNKGIFIRITRPGPGQGEEYQITHPDAQVNGILKGSYYGTMSDVVSVTVRGGEEKTKLRTLIEYKEESWLGKPRFALEGVIYRSTEEEGEEYKKIKSVPSDKVVAHLEGNWMRQIKYRMKGEKEWKILLNLDELALIPKLVRPLSEQDAQESRKLWDPVTSNLIAKNWGEATKQKQVIEQRQRDKAAAMKAKGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV95</accession>
    <name>K1VV95_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV95"/>
    <dbReference type="HOGENOM" id="CLU_702457_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV95"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="393" mass="42925" checksum="F125B486A2661760" modified="2012-11-28" version="1">MGWSTEYSPSDSGSNEWPYWTSGNSGSDQSVSDPSDGNNSEQEDADSGDENGNENGLAPVTPVPSVESIGDLPGLSHENDTETTASLATVENSNGEQGGTVIVVQLPTHGPEWDVSDVEGADSLPAYDEDTPPVYNAHDAASTQPPVQLQIDVQFTAQPSPTLPRTTHGPSCPCAVCVMVYGPQTLNVTPPQPSAAELEAERQARVERWRAAHANSDSEASEADETTPLNETEGHWGYATVAAMSHEENERRQRRQRRRERRRRQQQQGYARASIRRSLEIANRVYAVSGLLGNCRTEYFLALCCECLLCHLKPADTPRPRHLRRGLPAVRRARPRHLLGAAVPVQREALQHPDRVGHAWVPRGGPPEGPPRLGVDRPRACRRRGRALRSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVK3</accession>
    <name>K1VVK3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_04853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000333">
        <property type="protein sequence ID" value="EKD00843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVK3"/>
    <dbReference type="FunCoup" id="K1VVK3">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVK3"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_0_2_1"/>
    <dbReference type="InParanoid" id="K1VVK3"/>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD00843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="10926" checksum="A1CEF347A1A30A30" modified="2012-11-28" version="1">MKHIAAYLLLQNGGNASPSAADVKSLLETVGIEADAAQLDKLISELEGKDVNELIAEGSAKLASVPSGGAGGAAPAAGGAAAAGGDAPAAEEKKEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVM7</accession>
    <name>K1VVM7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVM7"/>
    <dbReference type="STRING" id="1220162.K1VVM7"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_1_1_1"/>
    <dbReference type="InParanoid" id="K1VVM7"/>
    <dbReference type="OMA" id="WHEPLPA"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="198"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="426"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="623" mass="67373" checksum="37EF6C89636B5D10" modified="2012-11-28" version="1">MAPVAATSTTGFFQVQPDIPNQFIEDAALNRAAHLFLSQELREQRSPDLIRFADFLRTPEVWSWVANAEHDLPYVSGNGFRAFGTPNPDPLVTSNGWKQLQAAGIREGIVANGYEHELQAYARVHQMLKLYLWNPASATVTCPSAMQDGAISVLLRELLRKDVPGYTADQLPLRKKVFESALMRLMSRDPSYAWTSGQWMTERAGGSDVAGTQTVATHVGLGGNEVDGNGHPLGPWSIDGFKWFSSATDSGCVVLLAKTDDSGRLSCFWAPTRYYVNGVEHMNGIRIQRLKNKLGTKSLPTAEVELKNMRGWLIGEEGRGVVQIATVLNITRLYNAVSAMGSLGRALGVARAFARIREFPSRKPPNNVLRTLPLFVKTLAGVTLTHRADTLFTAFVSALVGAGDHPGAPSAPLVPNNPAQVAALIRILTPVLKSSTAKHSIAGVQECMESLGGVGYMENVENPEMNLACQFRNANVLAIWEGTTDVLSTDTVKVLHGRGGKATVAALDAWLRSSLPGGPESEEVLTAWSRITQLAQPQRKAEAIARARQITFALADIVAATLLLADAASDGNALALAIAQRFVRRSATFPGLQADEDDWEKECKLDAAIAFEGEANLKAKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW85</accession>
    <name>K1VW85_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW85"/>
    <dbReference type="HOGENOM" id="CLU_1195604_0_0_1"/>
    <dbReference type="InParanoid" id="K1VW85"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="232" mass="25636" checksum="E667E8FD0F6BD592" modified="2012-11-28" version="1">MSSEHPVAQAATSTPPPQSNPSRGLKRRRLSTCSLSDPENPPELSTPTKRRKIHPDAATASVRDCSSTTTRPRPSVATEVAEWINTILADTRTESEINSPNSDAGVPAWAGPGSWLEQYITTCVEGLRQFDEMHKRLDNIELQKRKEAEEQRKLYASIDRTPLTLSSGGPGCCTWCESTWCDDSDSDEEPDYYGDDDSGCERSEQEYDSDGADGADEGADEEDDDGWREDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWB9</accession>
    <name>K1VWB9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_01958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWB9"/>
    <dbReference type="STRING" id="1220162.K1VWB9"/>
    <dbReference type="eggNOG" id="ENOG502SB0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894342_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWB9"/>
    <dbReference type="OMA" id="IAVCRIP"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="45"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="28929" checksum="F1AA24E38A7B1252" modified="2012-11-28" version="1">MILRPQTARTVARSMRSPGCSRPSSSKAGSGSPHHQPALTMRDVLRNVAQPVVVAVTKTNASSPAPYHGATLTSFASLSLEPYPLVAFSLRLPSKMADYLRPCSNHTIAPGKGVEIPLNSCDNDCAAPTGTGSECGTSPAAPEATAPTPTPTPKSTCPELMVSLLSSSNQAIAEALARPGVDQRPIFGRYEWDDSDPPALKDAVGHLRCQVIHSMPLKAVCDGLANLDFEIEKEKAHLLGSELFICRVVDSNLGQGKESLVHYQRDYNSVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWW7</accession>
    <name>K1VWW7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="AMBO01000163">
        <property type="protein sequence ID" value="EKD05011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWW7"/>
    <dbReference type="FunCoup" id="K1VWW7">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWW7"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_1"/>
    <dbReference type="InParanoid" id="K1VWW7"/>
    <dbReference type="OMA" id="QHYGEHK"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD05011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="152" mass="16810" checksum="9C2C1B45D00E4A99" modified="2012-11-28" version="1">MSVNEQTYIMIKPDGVQRGLVGEIIGRFEKRGFKLVALKLNQPSKEQLEKHYADLKDKPFFPSLIKYMLSGPVVCMVWEGLDAVKTGRAMLGATNPLASAPGTIRGDYALQTGANVCHGSDSVENGQKEIALWFPEGISQYKLSSADWVYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWW8</accession>
    <name>K1VWW8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1349 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000238">
        <property type="protein sequence ID" value="EKD03962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWW8"/>
    <dbReference type="HOGENOM" id="CLU_082825_1_0_1"/>
    <dbReference type="InParanoid" id="K1VWW8"/>
    <dbReference type="OrthoDB" id="10453061at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31303" checksum="7C0EFCC7F4503486" modified="2012-11-28" version="1">MQHSEQGKLPTHHHSTHTAPTRAASHRSSSDTDAPCALPSLTSPTLSARPPPSHPPRSSPTLHRKSMSADEVVVPGLPPLDWALKPGRAYVTQSSLFLEANGSTDWFCPGPSQNPRLNARPLGFSAPGTFALSAKVSIKGERSVYDAPALIVWRLSSPKRHWAKLCFEQAPALSPSPSPDGEEDVNGSPGPRDTGTTGPVSVVNHCDASDDASHGATDGEALYLRVSRTGSSSFAFHSSTDGRRWDLLRIFTLGGEGEIRAGFLAQCPMGSGCECRFEEIRLGQPPRNLRDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXA3</accession>
    <name>K1VXA3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000315">
        <property type="protein sequence ID" value="EKD01478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXA3"/>
    <dbReference type="STRING" id="1220162.K1VXA3"/>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_967052_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXA3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="150"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="31073" checksum="9C21D9E4173146DE" modified="2012-11-28" version="1">MSSPFNLLTTGARFDRSRFSNDFDLFTVSFRYCAVANWQKKKAKKDKGKGKAKDVLPSSLNFFGDSKAAPEESDSGSESDASSSSSSSAASIPEPPKQKITLTGPEPLPASLGTDLESLFEKDDTLKKPMLRNLASANIRSLWGVQCAVAGSLLDGQDTMCVAPTGSGKTLAYLLPLLVALKTPSRKMDDKDQGVRSLIVVPTHDLAVQIHQVLSAILPPKWRALVLSKATQKAVCESAPGPKFGKTESEDDDEEEEEREGNLGIDFLIATPERLHHLLDEGLVSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXJ5</accession>
    <name>K1VXJ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXJ5"/>
    <dbReference type="HOGENOM" id="CLU_1256830_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXJ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="220" mass="23455" checksum="963DC3B18A4B6441" modified="2012-11-28" version="1">MQRMYRGKLGMVLEAQRRHRASVEAGVASGSASSALEGVSEGVSEVSPEVVGLTPEGSRLASASSVSAAGGVAGPETMAGLDLPPPRAPSEPSISLTIVANKLRVSKLAVERRHAINRLRAAWTHVISHSPVAPVSTEHCYFLHVADGRVYDAVPFWELCEEAERAITSLARAIVAREMGGERRRSTGGGGYRRAGGEGRNAERRDLAKKKQIWRGTGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXN9</accession>
    <name>K1VXN9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXN9"/>
    <dbReference type="HOGENOM" id="CLU_719998_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXN9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="384" mass="38935" checksum="9C0A23CF90EF13F0" modified="2012-11-28" version="1">MHPRAGAPPRPTSSCPPVDEMWCIRATASDGLLPQPKLSSPAPFCTTTPSTMRSTTLALLLFALSTSAQVTVTVTMWETADASTPDSNTADSGNDPTPTANNWSPSATDDAEDSGTSTWNDNSNTDDNSDSNTRTNDTPGTAPTGEPYTASDDSGSGATSTRRRGKATTWAPAPTWTPDTDSWTPDASETGTWTEDNAWTPTGTGTGEASDTGTWSAKDTWTDTATGSWKPTGTGTRSGKVTGSAKPSGAQEVYSGTTGAWVSGTFVEGATYNGPAIPTVSGSRSGLLLPTGSGALNVPGTNVTGNMTIPSGTAILPPGASANASMPGNTPITSPSEPSPSPSPTQAASAPNSGALRRRELTKKTQYGLVLGAAGGLVLAGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYE5</accession>
    <name>K1VYE5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYE5"/>
    <dbReference type="HOGENOM" id="CLU_522945_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYE5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="521" mass="54544" checksum="0EBCB5712CF02DB0" modified="2012-11-28" version="1">MTSSPPGLARPWSPAANYPSRPTTPSHSRSPPRSMPPSPSLHPERLERSRAEQSLLSLLEREQSLLTVLENEQKRAGKPRRRQRSVTISDVDRSASPTRPSTPVFDPRLSTNPVHAMDSKPGKKRSIGESLWKEHGYHPSHGHHIRARNVSGTSLKSIASIDSLPDVDLVSLVERSIALRNPQQRLAPHFSTSPVLRAVDAGVGATTSPGTSTGGTPKIGIQTPSLKSSTSSVKGGAASGKLRASTPATQNSPPKRPPTPRKVSPRPTATHQRSSSAIPKTLERPILPHRAASDAMTGATSRSLPSGSGGMSMARQPSQSGQSRADHLDPSPKLGPRQRSKQSPAASSVISSPLSSGSANDEPSPPSFDLNDGGILTPCTCRTSYFADKRAPAICTCSASRPGRPTPGLGSGGPSGVGITQRSASASASTSSSPPLSAGGSASSGSGKTVRPVPISATATCMSSDEGGPVLMPKTSGSLQSAWSAERASRKLKQQEGRVCFDEVLGIPEDKRGSGRRWSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYJ1</accession>
    <name>K1VYJ1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000043">
        <property type="protein sequence ID" value="EKD05651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYJ1"/>
    <dbReference type="STRING" id="1220162.K1VYJ1"/>
    <dbReference type="HOGENOM" id="CLU_886194_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYJ1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="314" mass="35074" checksum="B8123FD8B4361327" modified="2012-11-28" version="1">MPPVYQSYPQHFVYDSGSGSRGPGSTVGPSPTHLYTPQLIMPIEQRRPQIHVNVPMQPVKPTLTFGYTYTQAPQQSDHVHHSYYTSGILDGGAEPEPAAARMAHTRSTHFITPQAHPIRHAEPVAIAESSATVERGRKTLRAKQVPRGPRVVGQCHADNPLAPIAWRGGPCASKKLRRGKRISEVEQLYGKSAMNAVHTCKAEDLDTANSSAARTAERLPELTREFFASPFFRRFHVLHPIVDQLEFVARYLCNCTRARRICNYCAVPEEVNRATRERKAAAEADAKAGYAHQRVILSHVHELRVRRSSMEVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYZ6</accession>
    <name>K1VYZ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="9" type="ORF">A1Q2_03698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYZ6"/>
    <dbReference type="FunCoup" id="K1VYZ6">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYZ6"/>
    <dbReference type="eggNOG" id="KOG1628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYZ6"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="258" mass="29104" checksum="AC02DA9BE50B153D" modified="2012-11-28" version="1">MAVGKNKRLSKGKKGIKKKVVDPFTRKDWYDIKAPSYFENRNVGKTLVNRSQGLKNANDSLKGRVLEVSLADLNNDQEQSFRKIQLKVEDVSGKNCLTSFYGMDFTTDKLRSLVRKWQTLVEAHVDVKTTDGYILRLFAIGFTQRNRNQVKKTTYAQSSQVRAIHAKMTEIMRREGEASDLKELVQKFVPESIGREIEKACKGIYPLHNVYVRKVKIVKAPKLDMSKLLEMHGEAAAQPGSKVSKGGDFVEPAPLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZ55</accession>
    <name>K1VZ55_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00798</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZ55"/>
    <dbReference type="FunCoup" id="K1VZ55">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VZ55"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="InParanoid" id="K1VZ55"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="342" mass="40300" checksum="406041277A6EA2CB" modified="2012-11-28" version="1">MSGSRSIARVYPDVNEKLGRSWWDYDNLIVTWGNQDNYEIVRKVGRGKYSEVFESVHLPTNQKCIVKVLKPVKKKKIKREIKILQNLAGGPNIIGLLDVVRDSQSKTPSIVSEYVNNTEFKTLYPKFTDYDVRYYIFELLKALDFCHSKGIMHRDVKPHNVMIDHERRQLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNIDQLVKITKVLGTDELFNYLERYDIDLDSQFDEVLGRYQRKPWSKFITSENQRYISNEAIDFLDKLLRYDHQERLTAQEAQQHPYFAPVREEHARNAKAAAASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZE8</accession>
    <name>K1VZE8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_00752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZE8"/>
    <dbReference type="STRING" id="1220162.K1VZE8"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289053_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZE8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF55">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD04952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="994" mass="107164" checksum="228EDF9696B7F36A" modified="2012-11-28" version="1">MASDQPIPLRHGEDRGLPQSDLVPVNRLRDDLDPSQSHEGQSNTVSVDAEAQTGQSTLSATGPEGGAQDKTAPPAKPWSGRALVWLMWVNCASAAFQHALLWYGKVNPSITLVNGDKKRAAAFVVADALTVCACLAMAVVLDLTGRAVGLSLAVSLASLGLLLFAVPPGIGTLSTGQVFYGVGFAGIRLVTEVLVANSTNMANRALGYASIATPWAAAPFAATAIRGKFGPNPQAVSAACIGVVLPLGSLLAAYLWHHRACDVRNAYRLHWDFEPKTFGDCRYLRRSLARTDRRCRVAVCPGAGRPIGLLSLAVHDARWKTASDEASQASQAPQGARIVCSGDTVPLSYTLWSANLHSYLQVAFNIPEGRSRQIISSCVAIDALWMLPIGSLVRRTGYYKIILIGSAPMYSLGAVLMTRAPNYDHSESRLLFALVIATLSRSSFEAVKEVALLSSADDRDAAIPFAMMSVWDKVGGMIGTTLADVLWSAVLPNGPRQYLSAEALSNPTREHPLLAQHLALAVGSPERLAVQKAYNGVQRTTLIIASAIMVLALGVALSMNNVNVLAGREASVRPAPWLRRLYRRVFRRSSSRSPHLPAPADSEADIGTELNDRGPEAPYCNEDCELGYLHHCPNLAKSFLHVHHPQSGDCFSVAVEADGTPFILYPIHPVIFTEHLRLGRPLWRLSEDVKNRHAGLGEAIARAIASAWLESGMLPIAIPDGDHPPFARFQTSETERTSDLPLGSDRLSHRISHHLAPPSLIDEFWGIQSVTPTPHNGYVSSDWPAKTKFPCEHRKPVSVSGGSDIGQEAEAEALDVFQVRMNLPADWTSRPPTYPGMLCRFCGLEERGRRCVEAQSWVHVHLGAVGMCWTFRWEAGPHRSKSRLGMAPDSPEVGLSDRQVAQLRSAIERNVSDVLGEHYGPHHSEGGSGPLGGSSLHRIEATPTGYDRAQGTGRDRSHNCGCSACSAANATLSPFHLGSHNLVDLWGLGLARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZN7</accession>
    <name>K1VZN7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_03415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000294">
        <property type="protein sequence ID" value="EKD02268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZN7"/>
    <dbReference type="eggNOG" id="ENOG502SF8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1416100_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZN7"/>
    <dbReference type="OrthoDB" id="3359404at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD02268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="192" mass="21941" checksum="DDAD535737648BAA" modified="2012-11-28" version="1">MALRTLARSALRFTPSAPAVRPTPLATPSRTLRLLQERVSGSSRRSFSSSSPVLRAPAPNATGTHAHSPLVPKNGQGINRPAKNNHQFWYREVFPSMIPIFVLSTAIFLALSLIRTHLSHNKSLEESREKIEQLESQLARTRLELKRRQERERRERERMLPLVVERVLQRVGAMEVEQEEPEVEEEDVRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VZQ1</accession>
    <name>K1VZQ1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VZQ1"/>
    <dbReference type="STRING" id="1220162.K1VZQ1"/>
    <dbReference type="eggNOG" id="ENOG502R50W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497994_0_0_1"/>
    <dbReference type="InParanoid" id="K1VZQ1"/>
    <dbReference type="OMA" id="CVYAPRQ"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="547" mass="58916" checksum="8A7AB7B694477319" modified="2012-11-28" version="1">MEDHLTPQQQQDNDAVAAAAAAAAAAQLGLGDLQPAPHQQHPYNLQQPDFSHSTHKDDGTQHQEVDVHGLEIPVQGQEDVIPTQDTDLDLSLNLSAPHHVEPPPRTSFGRPPSIRKACDLCHAAKQKCSGDRPSCTRCAQGGWACVYAPRQRRRTVPKDQKLANALDARSHLSSLAGTLGKKRKLQRDGLGLGGESMDMRVAMGMAMDLGLADEDEDEHLLTMTDEQMSIAIDGYLADLPLATFVQNLPHNAAQQQATDSFGGDFSNEHMPFSDMDQQTSALRDAIFSLHESAVAQQPAQDGTQATDGTQDGTDSQGIDNIDESHLALLDLSHANLGVEQDQTGTDTTGELNLNNLSAQYPAACQHVTMVPRVLALLNQHPLEPKPGSNTPLSMYIFPPLARSLRLFHSLVTCPHCSGSPQQTLPQLALLSRTTTILTFPVPPPPPNAAGQPSALITVHGARLSGTGISEAIESHIVGVVWDSWRASVREIFNAFERKAQDVIQQNAALTAAQDGQAPQSSAETQRAGLMFQAMSRLVSAMNEVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1W059</accession>
    <name>K1W059_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W059"/>
    <dbReference type="HOGENOM" id="CLU_1769395_0_0_1"/>
    <dbReference type="InParanoid" id="K1W059"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="147" mass="15957" checksum="D5426A70592D37DE" modified="2012-11-28" version="1">MTSSARTTRRHIDLSTVTPSQLDLSPSHLDKLRADLSQASTHLKHLTETIIAPEDLSALNERLDGIEADMETLRLVREMTDALRVTVCERELGRARRRVVCPLPVAESYASGVAGAQSGQTEGMLCRPKNYRRAKLCGSAGSAGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W078</accession>
    <name>K1W078_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W078"/>
    <dbReference type="eggNOG" id="ENOG502SKAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083702_0_0_1"/>
    <dbReference type="InParanoid" id="K1W078"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31674" checksum="9E54F1067E80444F" modified="2012-11-28" version="1">MPVTIDHNFFPHIVEEILFYADRKTLLASRFLSSSIRHVADDLLTGEGLSIVYSKSDAGPNSYSRSVSAVGSSLEAITNGPPRLRVPYFHPDGDLEAQYRAVGRASQLSLVCPVVTPEINNLLQCIQPTCHVHLDHADGFATSSQALCIPPTASLGLEVISFCCSPSNVETFGGDGPTTGILKHHSSFVTLHLFDECQEPLASFLPPCCLVRQIVTPTVERLEVSGNVCVLPFAFRLVNVKSNPNLQITLVHVEEDCRKLGRADVENLRHDTAVIFKIPVHQVHYVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W0G1</accession>
    <name>K1W0G1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myosin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_00527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W0G1"/>
    <dbReference type="STRING" id="1220162.K1W0G1"/>
    <dbReference type="eggNOG" id="KOG1836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514068_0_0_1"/>
    <dbReference type="InParanoid" id="K1W0G1"/>
    <dbReference type="OMA" id="CKANMKE"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD05297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="530" mass="57727" checksum="7E124D0251667F0A" modified="2012-11-28" version="1">MTTAAQNAKEKHDAVVLALNGELNDARQTHEAEVSALSDTLEKVRKEYDTVRSKLQSEIESLQSLSAKQTEAVEALKKDLDSAQAEAAERKAAGEQLAEELDASRAEAASRRANEEKLTAELEQTRTEHTSAMEGLRSVADRHEETSKNLRSELDLAHSSHKAAATKLQKQLEATQNSSNEHEANAAKLASDLEAAKKESAERHELGEKLRSDLEASRAESKKHETSALNLRAELESAQATNEQLEADAAQLQSDLEAAQSTSSGHKAVVDKLKGDLVKLRQTYAEQEGALRRELEAWHASSSEQAMGQASLQTDLDAERAMTAQHEATIRSLRGDLERLRASARPAMAGRRISAAKPETLEALEAAHALEVSELNAKIRQLQEESHAATTKAHELSRQLADVRSPGEGGLFFASAPGPSETASTRSFTPTSSRPSSPLRRRPVDADLPASVRHKRAVSLNALKARMGVDTRRRHSATLKSLQEDGDGDVPERSQTPGEEGRRETARRMEQFGDEIVYCCSACQGELVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4E7</accession>
    <name>K1W4E7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_01959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4E7"/>
    <dbReference type="FunCoup" id="K1W4E7">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W4E7"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_12_0_1"/>
    <dbReference type="InParanoid" id="K1W4E7"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKD03733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="144" mass="16576" checksum="614E10D86456C4F9" modified="2012-11-28" version="1">MSSLATARLTEERKQWRKDHPFGFYARPQKKEDGTLNMMIWEVGIPGKAGTNWEGGIYVVTMTFPDGRFTPPLFHPNVYPSGTICLSILDEEKSWKPAISIKQDLLDNANIGDPAQIDAYQMYKNDRPAYDKRIKQQAIERRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5L2</accession>
    <name>K1W5L2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(adenine(34)) deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_01432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5L2"/>
    <dbReference type="FunCoup" id="K1W5L2">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W5L2"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_8_1_1"/>
    <dbReference type="InParanoid" id="K1W5L2"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052718">
        <property type="term" value="C:tRNA-specific adenosine-34 deaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000039">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD04213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="240" mass="25841" checksum="F844F0C3F7D157B5" modified="2012-11-28" version="1">MNKAVYIAPEDQDEVDLGWMREALVMAEEALDNEEVPVGCVFVRDGKAIARARNRTNEWRNATLHAELEAIDHLLPFNPPPLSQITLYVTVEPCVMCASALRQVGIGRVVYGCGNDRFGGCGSVLDVSTSSMLDTNVSFEAVGGYYREEAIMLLRRFYMSENQNAPNPKKKTTRVLKTEIPPPPNVTVSASTSANASATASANQSKNPSRSNSNANLPLPIGGTLASTPKGTLTPTADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1W5Q3</accession>
    <name>K1W5Q3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Postmeiotic segregation increased 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_01472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000229">
        <property type="protein sequence ID" value="EKD04253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W5Q3"/>
    <dbReference type="FunCoup" id="K1W5Q3">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W5Q3"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_0_2_1"/>
    <dbReference type="InParanoid" id="K1W5Q3"/>
    <dbReference type="OMA" id="SFNNVQY"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="188"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="749"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD04253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="950" mass="103958" checksum="C1C7599F36AC0BBD" modified="2012-11-28" version="1">MATIKAIDQTSVHRLHSGQVVLDLQSAVKELVENAIDAGATSVGEDNGLDSVEVTDNGSGIKEEDWDGVGKPERPGYRGLADFSAETPHIKASLAGGAGTCRDIRFPRRSALGTRGTTITLSGLFRPLPVRRKEFERTAKREFAKALGILTAYALVPASVGDGRKGLTDRKRNTVLTTDGRGGVRASVSALWGAKALTGLVDLDLNFDVEVDRAMARREGLDVSAAQGQGRASSDRQYTYINGRPCNLPQVMKAVNEVYKAYNISQVPLAVLDFRLPPESVDINVSPDKRTVFVHSERNLIAALREALDQFYAPTRSNFAVGGASQIHRMLASQKPVIDDEAKEDNEEGSEDGDAGGGEDEECGEEEGGEEPSRNGAGSEEEDEPQPAPRKRRPDTIVATLDTTTASWSPQKRPRTSLLDKLKSYRSSATPAPASAVPADESPEPAPEPEQEPEMEPEAEENGAENEDIDMDEPEEEEPPSRSSRTSRSSASLVKESPLQRFWNNATRRSRQEEGVEEAVVVKEAPSQIERTSRRTEMLSQLRRRRDASEESEEEPQPQSDGEDEVEEVQVKISESQIPRPIQRIPGTTGIDRSPSPAVSREASVAEESAEAVGDEEGPATEGTAERRTVEPGHSPQEVDDLCCDSPAVGQAAPEEREAVHVDEPTGGYRDEITSTLPASEATLRFDMEQVRRRWASLSLSPQPKTDVATKLKKGQATSAAGVQNRDLASAEAALSRSIDKADFARMRILGQFNRGFIIAALPSSTEGEEDLYIIDQHASDEKYNFETLQRTHRIQAQALLAPKVLQLSAGDEITLLEHQDVVERNGFELKYDPDGVPGRRVKLCAVPVSRDTVFDESDLAELIHRINDGHDNPRTSKARAMFAMRACRRSVMIGTALAKPKMEQLVRNMGTIDQPWNCPHGRPTMRHLTTVEPSDQSGRGRIDWSKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1W672</accession>
    <name>K1W672_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000416">
        <property type="protein sequence ID" value="EKC97273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W672"/>
    <dbReference type="HOGENOM" id="CLU_839886_0_0_1"/>
    <dbReference type="InParanoid" id="K1W672"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33595" checksum="94B32AC7A26A2893" modified="2012-11-28" version="1">MSKVDFEFYPHIVDLIWEHITDPYTAGQVCTSWRKRALKLIYHHLSADMHNGRWRLWMKTDDEDIHCKYLLAGADTAPTLDSDAAARHTEILDVLWPRTWSGGSTTAKLAEKFPRLHTMRVHTKEYGDLKGIGETQVYSWFSRETSRVTIRAHEAQTLVVLIAVERAPLSDGLFDIEMRLSRQLLQACYDAKDLVVVFNPRPVAGAPRISSAPLARDVAEYLGVTCNSFNITVVGAESLLRDEVGGAYENFKSAVLRKLAARNSGHGVRFVTHEEYKAVVGRETYKLHCVPDVRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7E2</accession>
    <name>K1W7E2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000190">
        <property type="protein sequence ID" value="EKD04808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7E2"/>
    <dbReference type="STRING" id="1220162.K1W7E2"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041954_2_0_1"/>
    <dbReference type="InParanoid" id="K1W7E2"/>
    <dbReference type="OMA" id="KWQALET"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="11">
        <location>
            <begin position="66"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD04808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="284" mass="31813" checksum="4CBCE7C29B7300A3" modified="2012-11-28" version="1">MWITPKRIGEFFNDLGVRLRDMGWKGMLILSACINSPSCYSCMPWGTQLTPVLSSHPPLFGFSGSMTLMGFAYGVWPGFLVASLASLAGAAIAFLSVRTFFLEWMRKFGSGKNKQWQAFGHVMRERGWPLVAMIRWCPLPWAIGNGLFASIDAVQFWQYMLANTLYLPKLFIPVFIGSRLSSMLDDPDNPKHKDPVQFWLNMASIVATVVFSVVTGLVIYKLTLRQMRKLEMHEGCDPEEGELAAEALESTALLRDYSEEDDLALLEGGVRRGAARERSPSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1W7K7</accession>
    <name>K1W7K7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000187">
        <property type="protein sequence ID" value="EKD04873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W7K7"/>
    <dbReference type="STRING" id="1220162.K1W7K7"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="InParanoid" id="K1W7K7"/>
    <dbReference type="OMA" id="QHALKFY"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="273" mass="29458" checksum="A09EB53019DA58CA" modified="2012-11-28" version="1">MVTVTQTTTKPTQAILKLRAEGRIAESDLPTEAKMAEERLAGAFRIFAELNMDEGVAGHISVRDVVNPHAFWVNPYGVAFDAMTVDDLVLVDHDGRVLEGGRPGFGQVINAAGFAIHGSIHRTRPDIHAAAHPHSFYGRAFSSLGRNIDITSYDGAKFAHTVKLYDDFGGVVLDDEEGKNICKALGDEGKGVVLQNHGILTVGSTVDAAVAYFIRLEALCRAQLEADAAGGARSLNNPEVSAVFDRAGGEKEAYRQAQELYEWIDDITGGDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1W8J5</accession>
    <name>K1W8J5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W8J5"/>
    <dbReference type="STRING" id="1220162.K1W8J5"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="InParanoid" id="K1W8J5"/>
    <dbReference type="OMA" id="WVVDEWT"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854628" evidence="5">
        <location>
            <begin position="20"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="109"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="482" mass="54368" checksum="1B61E92220569435" modified="2012-11-28" version="1">MTLLLVLALLAVRAALVASRAFDALETDTLAALAARAPAHSAHSAYSPRGLVKRGGWFNYDEWKVRGVNLGGWLVLEPWITPSLFDGKPDWVVDEWTYAEFTKDNRSELERHWDTWITEQDLRAIAGAGLNTVRIPVGYWSLIPLEDEPFHTGAYPYLQKAVQWARSSGLNVILDLHGAPGSQNGFDNSGRRDQRSWFQNQHNADRAVDAVLNLVREFTKPEYGGAVSAIQLLNEPFPHEDWELSFVKDFYTRAYRSVREIDSDILVILHEAFRQLDTWRDAIPEAQRVALDTHIYAMFTPSILSYGYVDNLRWSCGFADTLPASPYWTIVGEFSLANTDCAPALNGRGRGARWDNTLSGAEKMKFPGNCAERTGPDPEKWSDSYKQQLSKSWQTQTWVYERAKGWVYWTWRTEAAADWSLLTGLSHRFIPTPITALPDGQPCNFSSFIHNSRYARDEAAAARIKPSLLDVVALAALALLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1W9H0</accession>
    <name>K1W9H0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_07292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W9H0"/>
    <dbReference type="STRING" id="1220162.K1W9H0"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256832_0_0_1"/>
    <dbReference type="InParanoid" id="K1W9H0"/>
    <dbReference type="OMA" id="ENATDHK"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC98278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="220" mass="23056" checksum="D0AE8466FCA2D873" modified="2012-11-28" version="1">MSEEKVATDTKPVLDVKPEVSAEPAAAPAAAPAAAAEASNGSSKRPADDEEAAMNADADGKPDNKRGKFFDSRGGKGGKGSKGKFQQQQREKREKNKEKGRARGQRQGGWKARGEVDEEAAMNAAAAGGSTAPVKKEGEDGEEKEKRLPKKRAAVLLGYCGTGYSGMQIQTHGSKTIEGDLFEALAKAGAISPENATDHKKVDIQRAARTDAGVHAAGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA37</accession>
    <name>K1WA37_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA37"/>
    <dbReference type="HOGENOM" id="CLU_991067_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA37"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="281" mass="31090" checksum="D8DD78372620A877" modified="2012-11-28" version="1">MDFPDLLAPALKAQNALIDLCLTDIAPLFNCDLPQALEGLRLLPTAAYLPLQRRPAALDRVQIWRTGRVKDALDPKKLARVLSDLAVRRREDVLQDLLAVDWTSDALCQVLDVIKDSKEPMSLINLNLSEVQALLLRNKRDERQLDVVTNSRPDVETLALSFEVGYSVADVVGVVARPKKAVLGSFTNSDGRFIAAKELAHVDVLHQAATEEPLTSMVFSEEEEACRAAGYNVMLLENAADSLSTNSEDPSMVHQAYLWLLLDRLQEQSDHIPVSKRGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WA63</accession>
    <name>K1WA63_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000060">
        <property type="protein sequence ID" value="EKD05638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WA63"/>
    <dbReference type="STRING" id="1220162.K1WA63"/>
    <dbReference type="eggNOG" id="KOG1851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028126_0_0_1"/>
    <dbReference type="InParanoid" id="K1WA63"/>
    <dbReference type="OMA" id="IINTHRR"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="547" mass="62894" checksum="7EAB194870EC3DE4" modified="2012-11-28" version="1">MFREEPSDESMLQDRVDTGWLVWGKEMEVARFAKWDEQIFELEEGCKSAMQLLFDACASDEWWQKLSGHFSQEESRNYPSASHIDLILALCQIIGVPILDKIKPVVQKLMADIEEKGVYDRHQTRALMEFIAGLLRGHVEWPGKDRQAFWDWFTPLLPDIFRNIRQDALRCWEITMDYVLHQQDPRRHKPLVDFMLTTALNTDWEGGSAYDLTRRVQLSRILVRCLKWRFTDWAPEFEKLYFSVFNCTYADVRTHLGSIMNGLDQLHWNASYPNVPALIEAVRNDPKCETDIMGILPPRQLQAQVDETMAKIEKFRADRPSGPKAAMSDHDTTATTLIHWLATELVDVHAVGTMPYIVPILPKIFEFREMNDNTSMQQNAGRLLAMITSITPAFQLVEPLMEQLISILHNSECLDVISACLKDENQEVREMASVTLSGFLRCSQRSMVLVLKDRFVRDMQRIKLPRRTLSPGVINPKYQSTLVELHAAVLGAVAIEPMPISASIRSCIASFKRTHEKYQERMTEDQIASMNYAQAGNSYSTHFITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1WB43</accession>
    <name>K1WB43_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta strand repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000379">
        <property type="protein sequence ID" value="EKC98878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WB43"/>
    <dbReference type="STRING" id="1220162.K1WB43"/>
    <dbReference type="HOGENOM" id="CLU_419313_0_0_1"/>
    <dbReference type="InParanoid" id="K1WB43"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="654" mass="69506" checksum="B07F4AAD393D59C4" modified="2012-11-28" version="1">MPACMRGLYGCSRASSSALRNSHEHDFALVDTLRDSSQQNKGKPPSRLQQHPKIWMRCPGTCVRVLRSVASPPRSVHAPGTCTLCTLASCIFAGRRHIDASSGDFCALCAKGAARVHREQGLEAVVDKACRTLSPGIRVLDVVQVSFPILFCPSPSPLQGLHHGWPASVDHLLTFKASYGTPHNLNKEKMRLSTFALAAFLPAAAFAAPIKIESGAVMPRDSATLGKNNHPAVYRMRKRDNWGGDGNDNKCTPKGHRKADWKGKHDPASSNYDPNADKSKHRGHHGDGKSWHNHDGNKDGNSSWQEQPASAAPSPAQQDAAPAWTEAAAAPAWTETPASSEEAAPSAEAPAQSSAAQSENAWIEVPSSTTQASNDNPGHDFHAQEPETTSSAAPEPTWSAAPEPTSTAAPEPETSTGVAPEPETSTWVAPRSLAEEGLADTNKQATHVQAGGETTSSAAPEPTWSAAPEPTSTAAPEPETSTGVAPEPETSTWVAPEPEPTSEPAPEPTPEPEQNNSNNGGGGGGNWDFPGGKATHWNTAGEDYWCRTAPGVGSSLTNGDYDMVVAISWELWGGNPNQPQNYDKCGQWVELQWNDRPPVRAQVIDACMSCSADHIDLSKGAFQAVGAGLGLGEIGTHNPSSDYEKPDSFKWRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBA1</accession>
    <name>K1WBA1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_06707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBA1"/>
    <dbReference type="STRING" id="1220162.K1WBA1"/>
    <dbReference type="eggNOG" id="KOG4765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688904_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBA1"/>
    <dbReference type="OMA" id="HTIRIYS"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="4">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKC98953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39845" checksum="2DFADBCA26A9380C" modified="2012-11-28" version="1">MTTTTEEEDIRDLFNIIYAGEDWDDEEAPAKDTELLSRAVLDNLLQPPQLKYYTPRSRSPTVIPSTVPIPPSTTGYAPFSPLPLLKRLQTYGHVYVPNPLSAQALALAGWVASGGAFKCETCDKVWGLGQLDTIKKEAVRRDVLLKLSRNLRSYHASSCGWRYVSTPEETVREVRSLLNPTLSSSLAPLRQALQARVLSNPTLDAVRWASPLLPEELDNLARNLDKYAQLHLQFPDQENEPAAPGDKEQFASALAFFGWYPFDSSDPDASCVQPGGVGGRTEIVRCRQCLRRIGLWKHVQDDKAMDVLESHLAWCPIRGDWYNGSPLLQPPGAEEPKRILDEISISERPKKKWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBM8</accession>
    <name>K1WBM8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBM8"/>
    <dbReference type="STRING" id="1220162.K1WBM8"/>
    <dbReference type="eggNOG" id="ENOG502S0TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047034_0_0_1"/>
    <dbReference type="InParanoid" id="K1WBM8"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33383" checksum="437E06F224288F22" modified="2012-11-28" version="1">MADTIIELPKAHPPPHVLEVLGASGELPICVTCATQYPTPRKDYPRQWVPGSGQMWTFHGALMAERKNELLQDREDKRIYLIQTTPGFAINQTPGSVIWDCAALLTPALAAWLLNLERPLKAIAISHPHQFFSTSLMWSRALKVPLYINGTDRTWFRRASDIDADDRVEFWVGTKQLLPNVRLYQCGGHFPGSSVLHWDRDAEPDADSLTKGGLLLTADTIMVQADRRGFTFIWSAPNWVLREHKVKFRQASSTWPHRFIRENADQVFESSVEKYLAKIGWKEEGEKLVPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBZ9</accession>
    <name>K1WBZ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_06537</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBZ9"/>
    <dbReference type="FunCoup" id="K1WBZ9">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WBZ9"/>
    <dbReference type="eggNOG" id="KOG0571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="InParanoid" id="K1WBZ9"/>
    <dbReference type="OMA" id="GIVCAFD"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC99133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="594" mass="66181" checksum="A7B4795221E8046C" modified="2012-11-28" version="1">MCGIFCVYKKEGDLQAYRPRAIALSKQQRHRGPDWSGCVVAQDSILVHERLAIVGVDSGAQPLVSDDGKILLAVNGEIYNHLELRKSLKNPPEWKTHSDCEPIMYLYKENKDDITAMCNKLDGMFSFVLLDTSVTPSRLIAARDPIGITTLYMGWNSAAPETLYFASELKCIQEECDNLKSFPPGHYYDSNVGEMTRYFNPSWWDSDKPGKTPKNPVDLTAIRETLEMAVRKRLMSEVPYGVLLSGGLDSSLIASIAARETDKLAAEQERKRQEYRLHGSKPDGDIPLASWPQLHSFAIGLPGAPDLVAARKAADMLGTIHHEYTFTVQEGLDAIPEVIHHLETYDVTTVRASTPMYLLSRKIKAMGVKMVLSGEGSDEIFGGYLYFHAAPNAEDFHEECVKRVKNLHTADCLRANKSTMAWGLEARVPFLDKKFLEVAMNVDPAAKMFSKGSSQTKDADGRPHMEKYILRKAFDCAPEGKPYLPESILWRQKEQFSDGVGYSWIDGMKDHAAEVVSDEQMAKAAERWPISTPDTKEAYWIRDIFEGQFPSDAAAQTAVRWIPKSEWGVSSDPSGRAVAIHNAALDDAPKVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1WC40</accession>
    <name>K1WC40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_06505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="AMBO01000374">
        <property type="protein sequence ID" value="EKC99188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WC40"/>
    <dbReference type="STRING" id="1220162.K1WC40"/>
    <dbReference type="eggNOG" id="ENOG502SCU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653846_0_0_1"/>
    <dbReference type="InParanoid" id="K1WC40"/>
    <dbReference type="OMA" id="GNTWDDV"/>
    <dbReference type="OrthoDB" id="2596500at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="98"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC99188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="435" mass="46503" checksum="091EEC31F8EF9665" modified="2012-11-28" version="1">MNSTTLSPGDVVAGPSRTRARPPSQPAASSKAAPGPTTRTLKQPMTLRVAESSIAGTGAQDKEEYFRALKRKAELARRVDKWMDRVMEETVDRGPFQKALSYMHAGQYAEVEHERHLNGLCSYPLCSNPPAAPYRAHKRFQISARAKTIKEVEGNADEGFCSKKCRVKSQWVRENLGSEAAWLRGQVAPMELLEDMEERWELVWEGGRNGQYRRVKPAAAAGGEGMDIDGAAAASTGGRNTIASQPPPLASAVGGQTVGAAAATSAPLGGAAAAVPQPRPAASQQSSRPMATQASAAADSASAAPADAPAPEASEVHDLLDTLVIRERDTARDVPVPPTLNPPPAQLAPKPPSATSARKARNTSSMIDGANSKLAQSVLTAHRQMKPVLQQEGDSEEEEGYQEQEWEKAMGWGEGKELEAMFEEARRARELAGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WGY3</accession>
    <name>K1WGY3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WGY3"/>
    <dbReference type="HOGENOM" id="CLU_2887431_0_0_1"/>
    <dbReference type="InParanoid" id="K1WGY3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="63" mass="6918" checksum="C12B9179E28575DA" modified="2012-11-28" version="1">MGRSAKMMKRPTQKQKQVSKIAKAAAQPLKKREPSPEPVEAPSGGGKKKRKSMRTKADKKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH77</accession>
    <name>K1WH77_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">mRNA export factor elf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_05021</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH77"/>
    <dbReference type="FunCoup" id="K1WH77">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WH77"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_1_1"/>
    <dbReference type="InParanoid" id="K1WH77"/>
    <dbReference type="OMA" id="EDHRKFG"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="12">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="453"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="695"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="824"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="996"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD00829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1113" mass="120002" checksum="EFE2A6347439FF2C" modified="2012-11-28" version="1">MPTATSTPLPATPLAEDFTKLAAAPSNADAKGIADAIALELKKAPRTLDAIEEGKVVDVIQLWAASKSGFERESAPVLVERLCRSLGAGIEGVFIPILHSLLALSMDKGQPVRSAVNSALKALVKAASPEATRPLIHAFARELDESKGWRSKVAACKAIEEIVKPATTELVAAELGEILPIVEKAMHDTKAEVSAAATKAATTLCGTLPNPDVLKHISSLVGAMASPNNVPGTIKTLSSTTFVAEVTGPTLAVMVPLLTRALKERSTDTQRMTCIVIGNLVKLVRDPTVAARYLGGLVTGVEHIATGAAFPEIRAFAQTALDILLGAGASATATPLPPRDIIAGVNEALAVIAPILKIEGLAEKPTVPVTMSYPGHPVVAGALEFEANVIADLVEARNFVASVWEGKAVGGFCKLLLGSEAGTEAATEIRKAFLAIDKQKFASDEPEEDDGAEVVCDLQFSLAYGGLLLLNHTNLKLRRGHRYGICAANGAGKSTLMKAIRDGKVEGFPSEDELKCVMVEHALQGEDTSSSIIDFLCNSEKLKHIDRKTIADMLLSVGFTEEKQTHPVSSLSGGWKMKLELARGMLVNPDILLLDEPTNHLDVQTVAWLEDYLNNLKGITCMIVSHDSGFLDNVCTDIIHYEQKKLVYYPGNLSKFVEKVPSAKSYYTLAATSIKFSFPPPGNLVGVRSNTRAILKLVNCTFTYPGAPRPSIKNASCSLSLSSRVGIVGPNGAGKSTLIKLMTGETMPQEGSVHKHPALRVGYVAQHAFHHINEHLDKTAVQYIQWRYQDGHDREMMEKATRKLTDADKEMMDRPIEGKNGELRKIESLLGRQKLKKSFQYEVKFKGYDHKYNAWIPRETLIEKGFQKLVTQFDDLESSREGAGQRDTSAVAVREVLEAVGLDGDIAQYNEMSGLSGGQKVKVVIAASMFNRPQCLFLDEPTNFLDREALGGLAVAIKEWGGAVCIISHSQEFVSALCPEIWHVENGELTHKGKQNLADDAFDNPSQPGSRVPSARGTPRGALTPAGVATPDVASSAVTSAVTSAANSAAPSAVNSADEEEDIKRLQKLALKPKKKKKKTRNEIKAQEERRRLRKLNWLTYGGVREPDTEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIE4</accession>
    <name>K1WIE4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIE4"/>
    <dbReference type="HOGENOM" id="CLU_829460_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIE4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="380" mass="42914" checksum="DEDAAB9FA6CEA794" modified="2012-11-28" version="1">MLSPLPAEVLLVIAEHLEVRDLTTLLLVNTFFHSIFVAPAHQCVEAVSRQEPCVFPPLAMEKYAKHVQSINIRPHHSDVCKNVPEHSPIYVKLVRLYATSARVYHLVHEEDLYPPSGKAPTIPERSMRTSSAGRKGLNQLAASYEASARKPLSSQKQRYQAAARVADALYHSPGPSDDGLEPLIPTGMFLQFAPPRAQSFTAVVQHPGISWYGLSDPASIDSFADALLKGPRTLLRGVVDVLEDFCCPVSSLHRLWPVLKQFTLVLPEGVLSSECRDYLVQEIETRLREYDAPADRPPMPTVRILSMLEFMALPEYKDVMTPQQMALWSERSVLPHFNATQEYVKQCVEWSRRRRELLLRKYPNYEQHGSFEASLGPPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIF9</accession>
    <name>K1WIF9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WIF9"/>
    <dbReference type="STRING" id="1220162.K1WIF9"/>
    <dbReference type="eggNOG" id="ENOG502S4CP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074846_1_1_1"/>
    <dbReference type="InParanoid" id="K1WIF9"/>
    <dbReference type="OMA" id="SFNERGM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="74"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="220" mass="25424" checksum="E17C51C776D6ABFD" modified="2012-11-28" version="1">MFRNAARHTAQHITRNTPKTATTAKNIARMTTSATNNAANDAAAARRRMDMETIKAHFSLPASAEERAWRAPSEGMTSFHNSHKWEFNHAYQHAEDLDGKPLASFLRQCYGLVVHLGNHHRIEEAHIFPLLAHKHPSFARNAEHEDFHHQIHDGLERYSKFLREGIEDPSKYSAAKLRETLDSFRKPLFEHLDKEVEDLRPENLKKHGFTLAEIRRLPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPG8</accession>
    <name>K1WPG8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPG8"/>
    <dbReference type="STRING" id="1220162.K1WPG8"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="InParanoid" id="K1WPG8"/>
    <dbReference type="OMA" id="CIQPMGA"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="58"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="478" mass="50634" checksum="49CE1B40754D5862" modified="2012-11-28" version="1">MTKPTKWISEKARFGHGTAEVVPPSSSASSSDIEKGSEGALEDAVFGNLESGPNFRGVSAPGAFVLMTKANLGLGVLAIPTVFNLLGIVPGILVIVGCEMLLFWCARFVGPFKIRHPDVYGVADAAYVFAGPWGRWTMYVIFTVFMIFCTASAIVGVSTALNAMSSHGACTAVFTAVAAIAGFLLSSIRTLSKVSWIGWAGITSIIASVIILTIGVGVQDRPSEAPQAPLPWDKGFQVIGHPTFVEAMSAINIILFSSSATPMYFGVVSEMRDPRKYTRAMGASLTFLTAVYLIIGSVVYHYCGQYVASPALGSAGIVLKKVCYGIAFPGLLASLTIFNHISAKNIFVRVLHGSKHLSSNSVTHWAVWLGCTAGSVLLAYIIASAIPIFGSLIGFIGALMCPAVAIIPECLMWFYDNWWFTTKGLTAGKIVTGVINIVVILIGCFFTVGGTYAAVLDLIATSVDSGPWTCVNNSGRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPT3</accession>
    <name>K1WPT3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPT3"/>
    <dbReference type="HOGENOM" id="CLU_1054435_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPT3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="264" mass="28714" checksum="3FFCB841F565FB34" modified="2012-11-28" version="1">MSDATANANSSASIPIYVTGNVNSEYSFNGQLTAPNLQPLPQHNDSDPYGGTTENPHWFWDKTLDSNDIVCGTSNWTIRQVCCPRSIGIPNGDPNAGANCRMHATKENSQWWMNCTHEIAQANGGGDVASACWPLEKYMESAADAKYADLNFGQEKVERCTSLAQASSKNNYTMGNNYTDICCEQVMGHPSSYFSDVELGDSTMETNRSAYMAMDCNLKDKKDWTAFMKCMDQYTWAVCREVGGANTAGVSALVVAAAALALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSD5</accession>
    <name>K1WSD5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSD5"/>
    <dbReference type="STRING" id="1220162.K1WSD5"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_6_0_1"/>
    <dbReference type="InParanoid" id="K1WSD5"/>
    <dbReference type="OMA" id="WQAGINT"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29114" checksum="490FD75B84A61C9A" modified="2012-11-28" version="1">MPNPLLVIAQPLILLAGAVIFFPITVAKLALAQDWGALTSLRAFQDAWFGNMWKVFAPRVREAHEGRIVPLLQGKVRAGIKVPTAKHAPVSGTVIEVGPGTGNWGPCFAESAAGGKVDRVYGVEPNPDLHPGLLASVKKAGLQGKYEVVPVGIEDLRKAGIPKGSIDSIVTLLCLCSIPEPERNIRELYEYLRPGGHWYVYEHVKTHGVMRLYQCEFGASKASEVSETSKGSGGELRKQAKIRESKRVRESARDGRSEEGLRLTQQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1WTF1</accession>
    <name>K1WTF1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000234">
        <property type="protein sequence ID" value="EKD04149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WTF1"/>
    <dbReference type="HOGENOM" id="CLU_2672865_0_0_1"/>
    <dbReference type="InParanoid" id="K1WTF1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="75" mass="8008" checksum="14536534057E4017" modified="2012-11-28" version="1">MSVQNDVAPQPVPALPSPVSISYGPFQPISPDEPRIPIEYIGPPLDDFELKAPEPKQAVRPHIPGVDGTVDAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WWQ0</accession>
    <name>K1WWQ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000143">
        <property type="protein sequence ID" value="EKD05129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WWQ0"/>
    <dbReference type="HOGENOM" id="CLU_1195602_0_0_1"/>
    <dbReference type="InParanoid" id="K1WWQ0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="232" mass="25150" checksum="95233E5B788713C3" modified="2012-11-28" version="1">MGLGLDVQCLPVRASATRKRRAPALGQTMKSHSEGKPVKTLIGCESQSSSPSEGESLPQGLPALRARDSPVVSVILRTPKPVFASKVNTHNEEEEHESAIANQVANGLDDNVVAPPLSLAGNERLAGRNVADGADQDAVTEEDADGEWHTVDVHEALCEDAEDRIDVKIRLVEHREDRHHEVAVQEVEEEVEAVLLRPPRAALEVRRQNVDETFNAKRNGDDAEVRPHAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1C3</accession>
    <name>K1V1C3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1C3"/>
    <dbReference type="HOGENOM" id="CLU_2607722_0_0_1"/>
    <dbReference type="InParanoid" id="K1V1C3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="79" mass="7195" checksum="AE410E1BB41E33E4" modified="2012-11-28" version="1">MQRLHQGQEALQNLGGGGGGGGGIGGEIQNAVGGLGGGGGGQGVGQDLQNLAGGLGGGGGGQQGGGIGNDIKNAAQNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1Z8</accession>
    <name>K1V1Z8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1Z8"/>
    <dbReference type="STRING" id="1220162.K1V1Z8"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_1_3_1"/>
    <dbReference type="InParanoid" id="K1V1Z8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="297" mass="32364" checksum="D1F04B31B9609071" modified="2012-11-28" version="1">MSSLVIFGADGRIGGQLVPAAVGSFFVHAVTKTKSQNDEMLKELGATPHVLDLTTASVDDIVKLFKETKAEAVVNCASADDVRDAKSVKAVDYEGGLKVIQAAEKAGVPRFLTVSSMGVHDPDKMPGYYSNVSCLASKIMWQSDSAMRPFLEAKWQLESALHKTKLKFTVLRPGTLFDNYETGCRMGALNLVRDGSTVSPPSLERVLDAMPPTSRELVAQTLYACLRNEDSAGLTLDVVNGHGEISEELSIMTASKTDVWKEDQKTRDWDEATAKKESEDNAEQQKKEHPGPKIVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V203</accession>
    <name>K1V203_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V203"/>
    <dbReference type="STRING" id="1220162.K1V203"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_284019_0_0_1"/>
    <dbReference type="InParanoid" id="K1V203"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="398"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="744"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1068"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC97969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1095" mass="119058" checksum="AD68F60169F72322" modified="2012-11-28" version="1">MLAPLEHLNGRLMEYLSIFHRSSSRESTQAPDDHQGASRQQPEMSGKRPAYGVEAPYAASLKIGNRSTTSSVYSRDPDRPANPVANESDVEVLGHIQALPRNSRSTRPRVSSSPGHEKEQRRQQIEHETGLRRPGNQTGEGSSVRSNPSRFSARHSMRDEDEVPEPEENKEFPIQRTTREHRSAAPGSGRRSVGHGRKSERVSNSSPIRPSNWQEHIQVSSSEEEEKIEEQPQQRQLLSPDLPPPKLPPRSTQAAPATPVLSKKAKMRRKDGTLPSESGSSRRASLLAPKSGLPSSNVSVTPAAIDWAVVEAGNSNYVIHAQNVSLRQVGANKDHVLELVGNSGRRASLPLANVSGLQLAANISNDAVATIAKLWEGAKRSSKAVKPVSELSKRAAAAAVRRAETSKGKGKMPLSPSQSRLSLRSTRHSMTAAKPTVNTLSDDESPSTNRPQRRRSPHLDKHDLPKTDNDKKWPAYDSVKKWTKSVDVFQKDFIIVPVNENLHWYLAVIVNPRALIETRPLPADERSPSHAASAKPSRSVSTSAESSREGKDPLDVMSEGEDEGVEHIKEKVEDCHISPQPKPIQSMELNWITNQDSMTFSSPPKTPSPPASSKPKFKREAIDLSDRSNHKAVGDNLKLWLEFEARDKLQKEIEPTAIEYVEAKVPQQNNFSDCGVFVIHFLRCLLNDTEKVLEFIGEVKEEYETEMNRVWHAATTKELRANWIEIIQQLNLKYQEMKGQGESQAAASVPGVEDSQASVVQINPPDRPEPLLTVGEGAEPSTTGSTSSTGGTTSSSSSSSSSSAAPPDTRQPSAARRQDSEVISRAASKGVSAEPQTEHPDPPTPTLPNNSLLSDSESEGGASREPSRMRSMSTKVSSREEIDSHVLVEDSQPKSDDESSDEPSVLFSSDRPEAETGDTIVPDTVHELSEDELATPIHLSGDQVPTAVLRTAQLSSTNSKRNSSNFGSSPVREPPSSPTTRSARKVKSSRKSAPDGYKQQTLLGYRVNGASSGPSSAAQDRPSTPEAKEPAVDPSAPSSRTRNHTYKGKKRAVSGPVVTGSERKRARSNTAGIEGQGSSSNNPIDLDPDSGSDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V303</accession>
    <name>K1V303_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V303"/>
    <dbReference type="STRING" id="1220162.K1V303"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009423_0_0_1"/>
    <dbReference type="InParanoid" id="K1V303"/>
    <dbReference type="OMA" id="ENLHTRW"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="240"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="659"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC98294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="853" mass="92389" checksum="0975E80093CD551A" modified="2012-11-28" version="1">MESSSRPSCLSPSGPIGDPSPTKKLEVQAEEDDLAKQNAALKSSDGDMVGKLIIRRTFDKSKDALTFMGQPVNSLTATVDPPKADQQTMAGRAAQAYRQLASAPTTTSTDHYHCVLKGEVLYIYDNDTDDKECLAAIPMNKYNVEIEDKKGKFDGMEGKFFTKRHSIVLRYADTKRKGLPVLAKGMSSESNTQTKEAEKAPMEDWYFSLLNVAANKARHDRVFSLSHMKWLCERVQSQPDPSGLQWLNAMLGRIFLGVNHTAKVEQKLSLINPPIVGPLRATEVNIGNIPPILSNAMLKEMKPNGEIVFEARIDYKLPADLDSSCGRATIEATKLGFNAIVAARMRGLSGNIRIVIKGPPSDRIWWCFTEQPKMDLDIEPVVGPRAIKWGTLLSFIQKKMREGMAEAIVAPNMDDVPFFHTDGLDVRGGIFNVASRASAKAKEEEEDEKPSDEETEEDTDTPSTLRQRNGKAPVRQNTAMPTAGDDWAERHAMQRSETTPNLTARKSKPKPTRSSLGKSVTPSLQSSTSTEASHFEIDKADKPPPSVHSTTDRSDTLSTSTAFVHSTDPPSPVSLATSGSTRDRSVSNVSIESDPSKLTSAAILNAVRARDTATIEAQVSVAKQSVKKWGVNLMKKRNKKHGHEDGDEMSSLHSIPSVAEIHAPAPRHDGRSLQERLNAAAANARDHQRTPSAASTLSKSFEKDSSPHHSSTPPSTIVADAPTPSPETSTPAEVESIASPVPSVKSQPALEVPSRKDTPGSDTKSVASSASAKTQPALDVPDSEATHSITPPSPGPYRTQRHDSDPLNASSHHDAASDSERVSKPSAPKKPSSGEHDLAHMFKSAGDSIGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3F9</accession>
    <name>K1V3F9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_07221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000389">
        <property type="protein sequence ID" value="EKC98484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3F9"/>
    <dbReference type="STRING" id="1220162.K1V3F9"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008514_2_0_1"/>
    <dbReference type="InParanoid" id="K1V3F9"/>
    <dbReference type="OMA" id="QACEWGY"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="270"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC98484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="587" mass="64543" checksum="9EB2BF370DA71496" modified="2012-11-28" version="1">MAQRAHLLVQPLVRRSVPAAPRALGIRALSTETAPSSTGPDFSGTRVQDGEGQSTQPRTNRNRAPPSELPKLLRQLAKFKAEGQKPSARAYMEILSAAKQYGKDRRGNDLAIEITKAALRDAEAGKIDLGAGAFEELLWIAVDYPEILPSVLHYMEKRGYTPTTGGLHALSRAAGSSFEQQLLLVGEAMQGNQFPGRHVLNQLIYFACMWGQPRLALQFAQRAESMHSGLNLPTQNWVQILTASADAQYLEGVEAAWNRVVENHAYAPDEGLLLAILAVAGREGRTDIATAALGELANIKVKPQEHHFAPVLEAMCNEGRVPEALRLPGKMRAAGVVPLLRTVQPLVKVLDSEHVVDQAFYELEDMAQNNEPVDVAALNAVIAASVNIGDLQRARATQLAAESLGVKPDVDTFNLVIRACEKAGHRVLGDTVLNELTSAGLKPNAETYEALIHLCLTQVPFEDAFFFLEKMKAQGVTPPRSVYLELAFKCVRTDDKRWRLVVEEAQSLGYNMPPSLDRLAQQREQGVQARNRSFRPRNNGPRGEDGQRTFGRDYASRRRDAPNAEGEGEKTGGDRRKPRQPREQDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4M1</accession>
    <name>K1V4M1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4M1"/>
    <dbReference type="STRING" id="1220162.K1V4M1"/>
    <dbReference type="HOGENOM" id="CLU_1230677_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4M1"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="225" mass="25189" checksum="9812DBE536418116" modified="2012-11-28" version="1">MTVDNPSIRQITDADPDTVDRLAAVMAEAFNTRDDPMYDALYGGDTVPDVDDFNLVRCKGRVYDAIVNKLVFAIEEGDKIAAFATVFPPGVHSTKPTQNPYSAELEARTPSAILPTQNHFHDTIDSFERNAFGTDHYYVCFLATARWARRRGLAARLLDHVLGMARKDGKITTLTTATESNVSTVRSRVTDWQVPYYEKQGFKLVAKSNVELRGIDVPLWAFIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V5W9</accession>
    <name>K1V5W9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V5W9"/>
    <dbReference type="STRING" id="1220162.K1V5W9"/>
    <dbReference type="eggNOG" id="ENOG502RSAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019578_0_0_1"/>
    <dbReference type="InParanoid" id="K1V5W9"/>
    <dbReference type="OMA" id="SHIVFRE"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="595" mass="66591" checksum="4331262C9EC2083F" modified="2012-11-28" version="1">MSHVEDLKAAVQVMERVTESIRQFDTYSFTYIPPVIDNSSGTVWKGDETHGLRKFLEKIFLDETAFSQMLADGVNPRESPLPIALGHQTYWNTITHARGPIPAIRATFKGPDKKEAFVDVVAQGGAEWIRLFSKKPSHLIAEFREQDSYINSDWESDEDSGCEPDKEPSLDNSIIRTVDELLEVMHAQTPAPGGIIPRLTLRLSRIEEFPEGGHPDPRFAATFAAVRAKGVNLVFGDLSDVSGAAGALPATPTTFESLKPTRRINLDPTALMGLCSDILHHPLPVDDEEARRRFYRPEHLLGSDGQQSQNSRELYRAMCDEMIQPVVETLQAMLDGDNVEFWATRGSITYLQEAISDSEEAGVFGEGMEQRRMRRLTGLEEGDFWEGSRYEGKAGVLANMKLHVFDEDDKDLEHPLVKHTTSFHGSLGAMCTDLVSQYRKSLTDSKAARKLPAFLQAKRLPAPRVAKITTPFTVVSLESFAYGAREGMTTMTMSHIVFRELWGQRSWKEKGWSQSNYELEDSAPASDPRAVVWMLPYRSLAEAKRCRFLKGDYSYPVFVQRIVRDENGRRIPLPPGTRNLDDIPQAGAAPTSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6F6</accession>
    <name>K1V6F6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000368">
        <property type="protein sequence ID" value="EKC99584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6F6"/>
    <dbReference type="HOGENOM" id="CLU_1750994_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6F6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="149" mass="16719" checksum="D56D3429D3B5E480" modified="2012-11-28" version="1">MDAFKVPESFTEDDDQRFLNDTDLQPALDFVFYTSKILKENEGFLYSTPGGANEATMDAVLASAYRLAGRPDGMIQRTVTHMLEVVKQLKAELEDFATYASAPTDPESMETYDKVIAHSYQVDRSVMTAETMIADLEDAERELGRLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8A9</accession>
    <name>K1V8A9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Voltage-dependent ion-selective channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000346">
        <property type="protein sequence ID" value="EKD00180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8A9"/>
    <dbReference type="FunCoup" id="K1V8A9">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8A9"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044399_1_0_1"/>
    <dbReference type="InParanoid" id="K1V8A9"/>
    <dbReference type="OMA" id="FKQPAFH"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000013">
        <property type="entry name" value="Voltage-dependent anion channel protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="292" mass="30583" checksum="9F1D0A6DC48BF21B" modified="2012-11-28" version="1">MPQPVPPSWKDLGKSSSDLLLKDYPINGTSLEVKTLTPSNVAFKVAGTRDSKSNVINGDIEGKYVDFKNGLTVTQAWTTTNLLRTQVELENQIAKGLKLDLATTLNPAKSTKAAVLTAIYKQPSLHTRATADIFKGPTFTADAVVGHDGFLVGAEASYDVQAGAITRYAAALGFSAPEYAVTLHGLGNLSTFAASYYHKVSKDVEAGAKAVYDTKSTTGGVSLEVGAKAYLDNAAFVKAKINNSGVLVLGYTQALRPGVKASFGLALDTTKLNDATAGAAAHKVGASFTFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8F7</accession>
    <name>K1V8F7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8F7"/>
    <dbReference type="STRING" id="1220162.K1V8F7"/>
    <dbReference type="eggNOG" id="KOG3321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809387_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8F7"/>
    <dbReference type="OMA" id="TRTSLWT"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="5">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="343" mass="37445" checksum="195B688B408E4C32" modified="2012-11-28" version="1">MSGLDFSTRVDRIGNTRIERESEESRADVQLRGPTFSTDINNGEPNDTWAVAGCSDRPAGDPVCCLELSIHHRATDAVTASSSQEAPVDPFKGRLVIENGIVHPPVLAEETAKAFNFPPLKKAPKTHGVLVATLHLRAYFAYHVDLQSNFALHAAANLNMPTSGVISMPKTKELVTVLKSPFVHKKSMENFTRYTHKRSIKIYDSDPEVVDLFLRYLKRNSVGGVGIKCYLHEWEEFGFGSKDIAPIEHLKEANTKAQSAARVKDLVKELGGETFQAPKPTDPSKVEQNPEGVVAAEEAQVEAAAEAAEAAKPVTETPAPTEEAKPETPKEEAKPEADSTPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9B7</accession>
    <name>K1V9B7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9B7"/>
    <dbReference type="eggNOG" id="ENOG502RB53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046153_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9B7"/>
    <dbReference type="OMA" id="HNIHDTE"/>
    <dbReference type="OrthoDB" id="2565065at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="407" mass="44260" checksum="8E9F31CE01835F5F" modified="2012-11-28" version="1">MAPTSQGESTTMGAVMPSTVGSSGLNLAAINLDPSLLALASGTSSTPLDPALFTIEQVVNDVREGRIGPDDLRDEPKPPDHTEEGVSEPVIEEEPHPHTHAQPEPEPEPETELQLDDDGIDPALREIVNSLTNAQQSHPIAPGDERETLDRERLQHTLQSTLEDFAQGNFGSYGAIFNTNFPQSPNHLVLPLEEPVPEPTVPVKRGRGRPKGSKNKPKPGQPTEPPPPPPRKPKGRPPKVRTAEELEEFERRKEEKALGIKRKRGRPRKYPELGLVREMRLKKNREAVQEKIRMLEERARLEEAAAENGGSAPPVEQPEAEMRSEEMPPSMSASDVAQVAEAVARQEQGNYAWSYPDGQSLLDVVGASYSSMQRGDIDDVVGSMDGGGGNVFGLPDVGGVSSVDEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9M1</accession>
    <name>K1V9M1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_08247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000411">
        <property type="protein sequence ID" value="EKC97440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9M1"/>
    <dbReference type="FunCoup" id="K1V9M1">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9M1"/>
    <dbReference type="eggNOG" id="KOG2143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005116_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9M1"/>
    <dbReference type="OMA" id="FECGHIL"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000013">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="802"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="920"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="977" mass="107944" checksum="60135C4F00B1B275" modified="2012-11-28" version="1">MSSPPPPNIILPPASPATPSRTRVGTLAAVDEEGTPLKAAHRRLNEALNDAGPSKPKASKGRRCHELTAEMISTVLESESYLFTAREIWALRHILELPYEPHYLLTRLLLRRPGKVHALSNLINAYSPELGEEGVKRAMTQLCFALDVPQHVLEEDPLPIVKESAPLSLDVTPSGSGSGTPRAETANGSNPWSSLPTGLSEEEEKKDPELAEAIRVSLWTEQHGPIPENGQASSSRIPNGAHGAQNGNSTTSQDTSESLKASLSSLGTLGLELANFDLQFSLEDTTAPEIRSLARDESELSLEQLLKCAAADDLRRVARGRKIPPSALATRESTVKALLDSARRQTTLGFAPVKGKGKAKDDGRPVSCMSTSERKVIEELLPCLGGHAIQIDRSVYTLVSRVNLIFSRTPPQSALAPALMLPPILVASSKRHYPDYGEPTRTPVWSSRAEMLMWERAVTWEALVSDALGDYWSQSRRGGPPALNFGRMENLSRTDGARIVRKVWEGVWPIWQEMIVAGGKEDVPGSRDRFRTEHVLSRIVYKVSYCSCDRADVRAPRHWACCTSTTRSARCCAHFWHNGAGGVESEALVLMTHYGKGNPEKAIAKLEEATQVCIDGLLDEDTHLSELPETRIKLMAVYRPGLSRRLTRLENKLNLPPEERHISYAELQECETRDIVAQRSQQNVGQPRLPRAESFTRGMSPDMEEDTVGIPQVGKSAWQGRDGEVTVEGCVLEFWEDQGYEGFHAESSILTTLFALLMWPVLFLPLPGAFETRYQTAPLDLGEDTFARARRDLIEERLEAMQKTAAAVEMLREADARERPRGTWAVGLSWDFGRQELEEIVECLGGRALAIICRMLSEEYRHRASGVPDLIVWNYPERIARFVEVKGPGDSLSETQKIWIDVLLSAGVPVEVCRIKDKAEVDSKPPPKRKGSLKKTPSSSSAGKGKARLPKVKTNGVDIIVIDSDSDDQATRKRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAG6</accession>
    <name>K1VAG6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_04707</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD01020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VAG6"/>
    <dbReference type="FunCoup" id="K1VAG6">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAG6"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_0_1"/>
    <dbReference type="InParanoid" id="K1VAG6"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="57"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD01020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="484" mass="54685" checksum="5AEA6A63E59EFE3B" modified="2012-11-28" version="1">MSTLVDYPTFSESPFFFDRRNLHIPQEEAKHIQDHSKPTVSYYFPKDVGNYHYGERHPMRPHRLMLTNNLVLGYGLHNNMDMYNPRKATEDELREFHDADYVEFLKRVTPKNAQQLTKDYTMYNIGDDCPIFHDLFNFCKQYAGGSLAAGRKLSQGGTDIAINWSGGLHHAKKGEASGFCYVNDIVLAILELLRYHPRVLYIDIDIHHGDGVQEAFYLSNRVLTVSFHKYAVDFFPGTGNLSEIGSNLGKHFAINVPLLDGIDDESYISLFKSVMEPTITTYRPSAIVLQCGADSLGCDRLGTFNLSIAAHGECVRFIKTFGLPLLVLGGGGYRQSSVSRCWAYETGVCNGVELPKELPPNNYYEFFGPDYSLHPPLSGHIQNLNTRQSLERIRVSIREKLRYLNGAPSVQMQEIPPDLQGFLESEERKQEEVDEEMNNGTAGEDRSDGPQKRNEYFDLEVGGDGHGASGVEQQTSRGKRTIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>K1VAH3</accession>
    <name>K1VAH3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 12">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_07959</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 12"/>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="K1VAH3">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VAH3"/>
    <dbReference type="eggNOG" id="KOG2968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_1_1_1"/>
    <dbReference type="InParanoid" id="K1VAH3"/>
    <dbReference type="OMA" id="SSGYVWR"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 11 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854027" description="Lysophospholipase NTE1" evidence="14">
        <location>
            <begin position="18"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="739"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="915"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="16">
        <location>
            <begin position="1262"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="241"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="495"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="785"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1485"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="11">
        <location>
            <begin position="1266"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="11">
        <location>
            <begin position="1293"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="1295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKC97760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1505" mass="164428" checksum="61018E3288BF7DB1" modified="2012-11-28" version="1">MAALAVLLALLGALADAEDARPTPPTMAGNPLVALAGAVVGVILHLLGLIQQVITFITITLPTFGFPHLVGLFVLVLGLVFFLVRYKYLTKYTQLKETALPSPSPPTLTNSLPLVDTDITERKRSSNPLHSYLDDFLSAIRIFGYLEKPIFHELSRHLQTRRLAAGDTIEVGGGDFWCVVEGNVQVFAPSADSEHTIPDPLSSNGSFNGYNLVNEVSTGGTLSSLFSILSLFTEDIKLSWDSEAPSPDRAASEEVPRTRANSDVSQLDGRVMGLSPLESTNIALEEDGDPKTPVHTDEDKSQEPESSPLSDEAQSPSSISNSQPGSSVTSPQATSPLPASPSIEATPIITMKPFPPDIRIGASGRGTPEDRRSTKPKIRNPMKGVIARATVDTTLAVIPAEAFRKVTRKYPKATGTIVQVVLERFSRVTFMTAHKFFGLTREILRSEASLNSMVSYPLPRSFYAGGGMQILREKFEPSLRRGRDRKQDDLMKDYFSYVPTSPNTRNVSLPSSRLDTPLRRPPLSGSDSHSKRTSDSEETAIGANEYHDTRSHSPLNAFTPRRQQSAHRKEVAAGDLAVLQDDGEEDTFYRPIKTPGLPRIDTWRGRIPSISSNDFYSDAEAEEVEEELEAELRGMLVECIAKSIGLLQPADSHPDSARRSVSASSSPGSPMFLPSGRPTSMRGPFGNVLDMINASPGGNDNISGLLRESLMNARLQADDDQSSISASMQESSLQGGPPDVNSAIMRDLGNRLEVLRFKKGSTLVKQGERAPGLYYVSISTTPAFEDHGSSTNLSSHRQPESSSRSRPFSAGMGQADPGSPVASFSGAGSADEEHLYTVNPGGLAGYLSSLCGTESYVKITAKTDCYVGFVPRQALERIIERRPLVLLTLSKRLLSLLSPLVLLIDAGLDWMQLGAGQILFEKGSKATDFYIVINGRLRSVVQKADSESVEVLREYSQDDSIGELDVITGADHPVTVQAIRETELVRIPSALFDAISTRHPATTVQFMRLIASRVRKGLSEQVLKHTHHHHGGELRADRNLKTVCILGVNKNVPVAQFAAKLKASLDEMGEASSYLDQATVMRHLGRHAFSRMGALKIAGWLSDQEEQHRIVLYVADTPPSSQWTQTCIRQADLILVLGMGDDPSIGEYEKVLLAMKSYARKELVLLHDDRFVPRGSTRLWLKNRPYIQGHFHVELPGHITSTKSTKIHDPAGTAAFKHLRERVETRIKQYRGLRPLGRPRRPPHMNDFARIARRLLGKQVGLVLGGGGARGISHLGMLQALEESGIPVDAIAGCSIGSFVGGLYAGATDLIETTGRVKQFSGRMGSMLRILSDVTYPHAAYTTGHEFMLVDGGYMDNTPISPLRASGIQDVIVVDVGSIDDTSARNYGDSVSGWWLFINKFNPFYKTVVPSMTEISSRLTYVSSVRTLEDVKSDPKILYMAMPVQDVETIGGFKKFSEVREIGLHAARKQLKAWAEEGRLPHPIADKSHGAIGQQKNTRMRRSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBA5</accession>
    <name>K1VBA5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBA5"/>
    <dbReference type="FunCoup" id="K1VBA5">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VBA5"/>
    <dbReference type="eggNOG" id="KOG2983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034402_2_0_1"/>
    <dbReference type="InParanoid" id="K1VBA5"/>
    <dbReference type="OMA" id="TFPDPNF"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="422" mass="46397" checksum="E479EE4171A49FD0" modified="2012-11-28" version="1">MPAPVSDSLPVFPTLKKADVDACRLSHWYDTFEDLTVPSSVIDIRKLGEGDAFLHWLDSDSIFLPVGSEAAPSSAPQTPAPHPSPAAGGNSSEAKGEEDDEAAPEYHLPALNNAINGVLRKYPQVFPKLNLTAPRDAAFVLQTSSGPLVCQRASDVYLFLKSSNLIHHDLEPERLYEGCEDAPNPWTATEEEKVQQKAAVPLELVLRKYISDLNPALEFRCFVRDGVLVGITQRDLNFYDHLQDEKTQDKLRRGIREFFEDELASNPPIAAGSSSSTSTTPPDNASYVFDIYVDTKGALGYGYQYEGDRFVLMDFQPYRSTTDALLFTYEDIRDILQKSREGGDGAEQLPVLRVIDSAGHPDAIRNQPTFSTNMMPVEMIELSEGRNLDEFREVWAQAVAAGMVDPADLPVGGPSGSSGQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VD37</accession>
    <name>K1VD37_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_07040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VD37"/>
    <dbReference type="STRING" id="1220162.K1VD37"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534407_0_0_1"/>
    <dbReference type="InParanoid" id="K1VD37"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="510" mass="55318" checksum="EA0E952D383FBF69" modified="2012-11-28" version="1">MEGDDAAGTAGTGSADGPETIGWRDSVPCKSYLAASADDKDMGNTNFSIVLPRLAFTRSAGAILVAKAVRERLDVPPCTTNARHDVVVRDPEELKVCLILYLQLTTQVSGSAYKIIQHRAYHHGTMLISSDLSTLGRALRSSSPNMVSKGVESMRVPVSTINLHRSPSAREITHGSFVSAVLGEFADVYGPSDVQIVSEQSVFGGGLVDTKSQAGIRDGMAELQGWEWAYGQTPAFENHFTGSLSCGEVRCEVESKHGVINSMTLEITSGGRGGEEQQEDEDALERIAQCCLGLRYEGLDGVGTFLGDSVRPDLSWEVLATHALIAFLDSTSLSLTLKLTPRTKHAFDRNKVSPPSNKADPSLAGLKDELAKAPSAIVILTSSSDDSGHWCPPCAKMEPYIQDFFGTSDATAIVVRLQMNEVMSDANWTLDAWGGGGVPLIHRIVDEGFRTDLARFVESEESHEAWLRERRGGAYEPPETRIPAQRARLDDLVAKHRELERKYKDVAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VDR1</accession>
    <name>K1VDR1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_06764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC99010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VDR1"/>
    <dbReference type="STRING" id="1220162.K1VDR1"/>
    <dbReference type="eggNOG" id="KOG3250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054426_0_1_1"/>
    <dbReference type="InParanoid" id="K1VDR1"/>
    <dbReference type="OMA" id="GTYKQFR"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="79"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKC99010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="262" mass="29310" checksum="98978D4B7365BF4D" modified="2012-11-28" version="1">MTDSRLEPFLLLARSAKGAAAAKVVENATAANGVYTFNALMDVPNVKESSDLQKHWNLLQLFAYGTLKDYISSPDSYPPLSPQQVAKLKHLTLVSLALEHRTLDLRTTRELENMIIDCIYSNLLTGKMHHHEQIFYVDQVSARDLNEAEVRKVESALKTWSSNAESILKALDQQIAEARESAIREAEQAAQYQKEQDAAYNQAKEELHKRDRHAMSGLSNRTNEMQSALPKSSMSSLGYGMEGKGGDSNEEMSHSRAKRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEI5</accession>
    <name>K1VEI5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_08198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEI5"/>
    <dbReference type="HOGENOM" id="CLU_1161860_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEI5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC97461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="239" mass="25589" checksum="62B439C29CD0B706" modified="2012-11-28" version="1">MRFLYSMLAHAPVNAEVSVTTRADVGDIEGIPQGPAFAEFVANRHSSPDKHQQWGRQLGVEAVELRGLSGAGYEEFEAVLRSRVAKNIFAAFFIMQLADQEAQVYSGAVLVHVPDGTWCLALGDAASSRPAPPMAKGILSSLASGCRTRFGIKLRPDPTMDGSLDGALEFTARLRAGPPDDAEIERTNAHVLKVIEQSPALYANAGDDNVVAEACAEVFGGETQIVLTAGPARRRRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEQ2</accession>
    <name>K1VEQ2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">A1Q2_06257</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEQ2"/>
    <dbReference type="FunCoup" id="K1VEQ2">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEQ2"/>
    <dbReference type="eggNOG" id="ENOG502QPJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_5_0_1"/>
    <dbReference type="InParanoid" id="K1VEQ2"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EKC99320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="256" mass="27416" checksum="97757D8B003D3B1E" modified="2012-11-28" version="1">MSKRTSASVKAEATAAVSPVTPMSEEKRKALQQYKDDDGHFSLVRNFRLADLITIMNGVCGTLSILLSARYLLESSNLPRPLSDDATRTLYTAIILPMLGFGFDALDGKVARWMGGGSMLGQEMDSLADLISFGVAPATLGYVMGLRTPLDVVCLLLFVSCGLARLARFNATVALIPADASGKSKYFEGIPIPSSLGLDAMMAYFVHSGWFAMGSHGDLPFGTIELIAGNKNSTIHILSIIFAVWAAAMVSKTLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VER2</accession>
    <name>K1VER2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_03186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VER2"/>
    <dbReference type="STRING" id="1220162.K1VER2"/>
    <dbReference type="eggNOG" id="ENOG502S7KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107714_2_0_1"/>
    <dbReference type="InParanoid" id="K1VER2"/>
    <dbReference type="OMA" id="CECMLFG"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16280" checksum="82B144729E55C47B" modified="2012-11-28" version="1">MSVTPQVASFVKDLYARSDVGPEGHDAYVDLYLPDATLVMDKVQFDGQAGVRKFREAGWEKVATRHHVCKGIFPSPSNPDEVMTYGTVDYGFKDGSKKDGIEFATRLVMDQSGKEIKIKFYQVYIVSGPGRARASERDARSGRPQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1VF73</accession>
    <name>K1VF73_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000278">
        <property type="protein sequence ID" value="EKD02670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VF73"/>
    <dbReference type="FunCoup" id="K1VF73">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VF73"/>
    <dbReference type="eggNOG" id="KOG0358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="InParanoid" id="K1VF73"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="512" mass="54542" checksum="DB04F27403469922" modified="2012-11-28" version="1">MAAVASTAVAAGPGASISDSAFNDKGKPTEVRLSNMNAAKVLITNDGATVLQHMAVLHPAARMLVELSKAQDIEAGDGTTSVVVLAGSLLSQAEKLLSQGIHPTTIAQSFQGAAAKAVEFLEQMSVPIDLNDKETLIRIAATSLNSKIVSQYSPILAPIAVEAVTRLVDPTSSNVDLRDIRIVKKVGGTIEDTTLVEGVALNQPVVSSAGGPTRMDKAKIGLIQFQLSSPKPDMDNQIVVNDYRQMDKILKEERQYILNLCKKIKKTGCNVLLIQKSILRDAVTDLSLHFLAKLKIMVIKDIERDEIQFISKSTGAKPVADIEQFTEDKLGEAALVEEADVGGARVVEITGVKHPGKTVSIVCTGANSLVLEESERSLHDALCAVRCLVKKRALIAGGGAPEIHVSRLLTQYAQTLKGKEAYCYQAFADALEIIPTTLAENAGLNPIAIVTELRNKHALGDANAGINVKKGIVSNITAEQVVQPLLVTTSAVELAAETVSLLLRCDDLVMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VGR5</accession>
    <name>K1VGR5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VGR5"/>
    <dbReference type="STRING" id="1220162.K1VGR5"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="K1VGR5"/>
    <dbReference type="OMA" id="LRQSWWW"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="486" mass="53626" checksum="CDB923DE3191AEEE" modified="2012-11-28" version="1">MNAQDEKSDYPVANFEEPAGRQRALRRLLWKQDLLLMPLLTVTLGLQYYDKAALGSAAAFGILKDLQLQHNGTTTRYATATACFYYGYIVAVLPGALLFARLNLRYAAGTVITLWGLVAILTVVVTDYKGLYVQRVFLGLLESAVSPCFVAITALWYKPQEQAKRMGIWYSATGIFSMFNGLINFALGSSGDAHAWKYIYYFCGAVTMAWGLVVMALLPPSPLQPGPFFNETERALLRRRFEENPFARDRQPLKWSQAREALLDIKTWLYLLVGALVYLCNGAVTAFGTLIIKSLGYSGLQSVALTIPGGAVTCVTIYIFTALADRFRDSRTWLFPISCIPVVVGAIVIWTAPWHPTAGPLIGYYLVASFGAPYVLLLALASANTAGSTKKAVTNGAIFVGYNAGNIAASYTVKTQEAPQKYKSTWITVIVAMAAASILMLVLRFLIKRQKDANDAEELSDDDVVMKVEEYQDLTDRQIRGFKYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH12</accession>
    <name>K1VH12_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH12"/>
    <dbReference type="eggNOG" id="ENOG502S4VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034128_1_0_1"/>
    <dbReference type="InParanoid" id="K1VH12"/>
    <dbReference type="OMA" id="LAGQWIN"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="576" mass="64155" checksum="94611D072C5DD18F" modified="2012-11-28" version="1">MGTDPLTPSSDDSKKREAIAVALALDDIPPSYEFATTVSTSSEAGESSAAGPSSAVAGPSRPWPESMDDLFTGPPNAEPTITKERAAAGPKIEVLERGIKRITIDPKLKDRAHLSLRPSLVGQGQGQRQKRGSELRACPAYLRHGPLPGPPRRRASPPRARAHGRAQAPRPSQASPNSSSLSIVVCRIELTSARALYDFIRRETLMPPSLTVRCFAFRNRTADHSQTVMQNGQPRVVQAGQQYRVTDFDFHIDLTPIYSHPENNANIFLYAKPSSEPAHRGTFSLTVGGPTEGEGGNKPRAASQAAVSVWKSWGEFCKNRARAPWGSLKDDEEFWATRGENSGQLTLSTRREDEEALLEGDAGSEADLRAWCEAFCADPGLLKSFTLRKTIWGWDFVSLRHAIERSILSTGYQPSADTPISIQFQVKDDLLVVQDSNWLTSLIQNRAIFFLLIITLIYPMIWLWQRFSARGGAPYDIARSTYAMKFYPPLPSTYPAETVQQAQDRLPGLFKLHPEVPRNPFLHKGPRGVHYLLGQREGSFYREWDERIRMAVRMFFHGELTSTLVREMEPPELDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH62</accession>
    <name>K1VH62_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH62"/>
    <dbReference type="STRING" id="1220162.K1VH62"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_615667_0_0_1"/>
    <dbReference type="InParanoid" id="K1VH62"/>
    <dbReference type="OMA" id="EFFGCIN"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="65"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="445" mass="48246" checksum="D989741B984484C0" modified="2012-11-28" version="1">MPPKKKAQKMALADFFAETTAAREDTGPRRGEPGYLDSMPDRSARTFPGAPMGRAENPLPDVPPFTAFVGNLTFEVQDDEVRDFFAELKPISVRLVKDSEGKAKGFGYVEFGSRDDLKNALDLTGQNLGGRTVRINVAEAPSRPGREYTPSAADEASQWRRTAPLAPREPPAPRRTFSGASHDDRDWGAARGAKFTPSRESSGYGRPRGEREHHHEPTAADEANQWRSAKPLVAATEGARGPRGGRDTPPHRPAGPADTESTWSRGTRVATPPAPAEPQRPRLNLLARSEKAEGGASGASSTSSGASPFGAARPVDTLAREREAEERLAARQAAAHKQREDAEKAKQAAKERREREHQEARERRPVRVHPSRLPPKEPKEAKEDEDGFEAVPAKGTRAAPAHQNNNDDSAPKSSGLKKENKGFSFAAAAGALDDELAEDTDKLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHU4</accession>
    <name>K1VHU4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carnitine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000384">
        <property type="protein sequence ID" value="EKC98681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHU4"/>
    <dbReference type="STRING" id="1220162.K1VHU4"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_0_1"/>
    <dbReference type="InParanoid" id="K1VHU4"/>
    <dbReference type="OMA" id="FIKQQKC"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016406">
        <property type="term" value="F:carnitine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="720" mass="80525" checksum="911FD309A83667CC" modified="2012-11-28" version="1">MRLPIKQATAARCIARSSPSSSLLTRSFVTTMPAKSKTFENQDKLPRLPVPPLDQSLQGYIKSLEPLVEAKYGQHGFQKEMEKRKLYAKDFASGLGAKLQERLKDLDHISANNWLDDNLWLALAYHTWRAPLIVNSNWWLTFKEDPRNPAPPVAPGATNKTVVPLDPNPAKTLPPGAQGGGQAWIDAHPNKKDYYYPVKYEDVTQREWITEWQVRRAAWLVSRFAGLRTMVQKEEVPPEASRLGPMCMNQYRMLFNISRIPLPNCDAFSAQDNDARHVTVHIADFVYSVDVFEKVPKGEIANPLPVGEIESLLQAAVADAKARVEKGEKPAQVGILTADDRDTWVVNRERVLLHSPKNRASMDMIDRSLIGLSLDTYTLPTLPARDDPLRMAQVDAQMHNAQGGLNGGENRWFDKCLTVVVETNGRAAIMGEHSPVDALIPSYVVDYALNEPVDDSKFTGGKAAKLGEGFQREDFEISPEIADEIEACRARNQAILDDSDCQTLWWAEYGTDWIKKNGKVAPDAFVQQVLQLAWFRDQGYPVATYETASTRFMKHGRTDVIRSLSPESRAFVKLMQDKNASQKQRYDALVAATKEHSKLTMDSSFGKGYDRHMMGPKVQLRPGEAHPLFDDELYSSSQAWKLSTSGLSSGIQFHATGFGAPFADGYGINYMAGPNLIKFGLESKVSCDTSSTTRFKHEIVQAFRDMRELCEAQTDAPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI02</accession>
    <name>K1VI02_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_06993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI02"/>
    <dbReference type="STRING" id="1220162.K1VI02"/>
    <dbReference type="eggNOG" id="ENOG502QRRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044368_0_0_1"/>
    <dbReference type="InParanoid" id="K1VI02"/>
    <dbReference type="OMA" id="MPRTIAN"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC98761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="358" mass="39829" checksum="3D598E3B6D32854F" modified="2012-11-28" version="1">MPPVRPNPALSQRRPGKSRLKSCNECVQAKAKCNRERPACSRCRVRGTDCEYGPRHENHETPRDTEGQSVGTISLRWLAAMTQENSTPPRSKMLSQTTIYYCCRFLRTFPLQLAECPPFVHPTLRHQRALANATTLMNMVQVRAPGSESLVSQTVLSEMGAIMSSAALAAFQAYLLLTMLVYFHLPSSKGMVTIETQLNIQSLADHAARLIPPVREEVRSRAEWVLSESLRRTIFTACVFDDTWNALNGITVYVAEELGRLLAPGPRSLWTATASSWAREWEAYASAWASPCMTVGRSGEPGLLLDELWGRGEMSDATREARTDHWVGHLDEFGAWILAICEMSGSGRNGAHDTSNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>K1VI42</accession>
    <name>K1VI42_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_06909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000381">
        <property type="protein sequence ID" value="EKC98806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VI42"/>
    <dbReference type="STRING" id="1220162.K1VI42"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_4_3_1"/>
    <dbReference type="InParanoid" id="K1VI42"/>
    <dbReference type="OMA" id="QMCCNAY"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="212"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="216"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKC98806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="464" mass="52344" checksum="556AA4F6DD67A5EB" modified="2012-11-28" version="1">MPPAPPAKFARTSMEGWSRKRSVSPSARAARVSPYKKNPAPSSSSTASSSSTAPLQSHLELETFVPRRSDDGYYYEDEYRDEHIAYLLKMENATLPQPELMGTQPEVQWRMRPYLIDFLVELHNQWHLESECLYLAINIVDRYVSRRVVFKKHYQLVGCAALWIAAKFEDSKDRVPLVREFYDMCCNSYEPSAFIQMEGHILTTIGWVVGHPTAVSWLRLHLTHSNSQLNEHPRVAAAARFILEFALYQQEFIGIRPSILAWGSLTLARFICGRQRRSAPHELLEPSEPQAIRIAQALDRILHENLESMSDVLVNKYTRERYHMCAEFVRDFYLSGRRYSCTVDIRRSQPLLHVPSTPGLSPPSWSSRRSSALTNSPGSRSSHDTSSDSGDEGSVPVTPSSEHPLTSTMDRYVVAAKENIAPSAVKLSKQVPAAPPTPTAYERSGPPAQPIPAPLRADARRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIH5</accession>
    <name>K1VIH5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_06690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000378">
        <property type="protein sequence ID" value="EKC98936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIH5"/>
    <dbReference type="STRING" id="1220162.K1VIH5"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="K1VIH5"/>
    <dbReference type="OMA" id="IFWVKSY"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC98936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="496" mass="55422" checksum="A6A178FB6D28FCE7" modified="2012-11-28" version="1">MSREEDAIKGSDGGASDSSQSIIQEKQGGRFSMSLERKLVWKLDASLLVFSVLGLVCRYLDQTNLNAAFVSGMKEDLNMYGLQLNYANTCWVVGYVIGQIPGNIMLTRFSPHYVVFALEFGWSLMTLCTTWITNYQQLYAIRFFVGLFEAAYYPGLHYLIGSWYSKKELGKRASLFQGACALGSLLSLVLQGGVHTTLNGKLGRPGWRWIFIIDAVISFPIAIGAFCMLPDLPDVIKPNWMFSQEEIDLARKRLDAEGRTGISKDAYTWAGIKSIFSTWHIYIFTAAYSLYIFMHSKSRSCGYSPSPKYTVEQINYYPAGIFALQLVTSLFFGWVDDVFLGSRRWPMIVLTNTCHLIVCALLAALPTYANGTTATGRWVLYYLTGMIEVGAGLIYAWAATVIHTSSEKRSIITATYNSVAFSFNAWLPLLLFKQTEQPTVFKGNVATSVAAGLLNVFIFLILYLSKRDERRAKLAGQVTPEIAEVKAEDVEDAPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIU1</accession>
    <name>K1VIU1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIU1"/>
    <dbReference type="STRING" id="1220162.K1VIU1"/>
    <dbReference type="eggNOG" id="ENOG502T0HW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654141_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIU1"/>
    <dbReference type="OrthoDB" id="2596940at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="420" mass="44958" checksum="4744F1F451911856" modified="2012-11-28" version="1">MNGTVPHPTAIALPPTFPAFLGLDDSTPLQVQAPNLSIMDLFHTAAVPQSVRFTSLASEKVMPSSASRMVPLGYLLSSLLLQSPGAASQQEANLFRDFLLLAQSDVEPLMTPDLPHDFSIADVTAVLGVTGSFWILPRAIAGYLTTGAGPQDLCVIQDDIDCLLVQEGCQNVGATLLPLPGAKDIEVAVTHDVNGLAARRLVRDKWNTLGYLASRFAPGGSLGADNKLFAFAHVPGAQLNGTTRFEHGVPVHEFKDLRANTRCVLESQAFGVKARATELGLGSPHRVVLVDNTDNHLLGQVFATDVYTPEVRQDAISFGAALLIHNLPQISQASYKTRNESAPNTTPPLTPSTTGPNSPPRFEAISSPKCPPSPAPSDTGVVRVRLITPKPQDTWEHELYNAMMPEFLRLSGIVVPSAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIV8</accession>
    <name>K1VIV8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ERT1/acuK family PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_04873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIV8"/>
    <dbReference type="STRING" id="1220162.K1VIV8"/>
    <dbReference type="eggNOG" id="ENOG502R1M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451426_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIV8"/>
    <dbReference type="OMA" id="FREKTHQ"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="9">
        <location>
            <begin position="496"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="604" mass="66228" checksum="5D683DE2AA490399" modified="2012-11-28" version="1">MSVYDAVSSVTTATTADSLSLTTPTPTPSPPHLVFYQHPQPQQQLIYHQPQQGIPFFEPLPQAHNQPPFACSMAPSQQQHNPSPWPRNAREPSEPSVSATTSSGSSPRTAPQPHTMTQQLPPNSNKQPVAPAPPAPAPASANQTTAPSSSNSTPQPKNTKRGPDGKVTRKKVAKACLACQKSHLTCDESPPPPPQPQPQASIPPPPSGFSGSPNNHPFGGVNINMLPGVLPLQQVQPERIPDNIWLTTPMVEAQPPPQPLQDWNLQQNNEPFNFTSTAAANLEYEMFDSMFASLSPSFPLGDIAAPPGNTGSTTDGSTPTIWSNLGFTDPNGPASDGTVMQNQDSNMSMPMMGQNQNQGQGQNQGQQQQQQPMEYTNSNGWQPEPQQQQQQEQPQQQPPQQQQNHDGVPKKMTPEELYSTVVKPYDYTEGYHNLISYLESNFEKPDFIRVVKALAAFRPSLIALQVGMTEEDDVFVERSFQRTLIELDKLISYSATPTAVWRRTGEIVCVAPQFCQLVGQSEEQLVGQRTPIWRLLSKASTTAYWENFAEHAFENSTQNFFQATTLETPKGSIPCAASFTIRRDTFDLPSVIIGQFLPIPPEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJZ5</accession>
    <name>K1VJZ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000325">
        <property type="protein sequence ID" value="EKD01071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJZ5"/>
    <dbReference type="STRING" id="1220162.K1VJZ5"/>
    <dbReference type="eggNOG" id="ENOG502SYVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1344085_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJZ5"/>
    <dbReference type="OrthoDB" id="2594031at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="204" mass="22395" checksum="5E1D2CC33281E82A" modified="2012-11-28" version="1">MSALRQVWAGYRFTGYVGDTIRELKVLRRCLRCGNGPPAPRFDAGSRRLFVLAQDYAAFSGRNTPYAGDLARAQAESGWDVGRLKREAKKRRIALPLPTATEPPEPPQPLTLASLPELGSDEKPRPVPPPSYAFDNAPPLPQPWTYKPDEVPAPPPPGNKVTSGVLDFIKLTATERGDIPPELGLVDYRRREGKRKWGTKGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKP7</accession>
    <name>K1VKP7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_08260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000412">
        <property type="protein sequence ID" value="EKC97337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKP7"/>
    <dbReference type="STRING" id="1220162.K1VKP7"/>
    <dbReference type="eggNOG" id="ENOG502SMT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855779_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKP7"/>
    <dbReference type="OrthoDB" id="3345311at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC97337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="35404" checksum="0909613DAC57188F" modified="2012-11-28" version="1">MTSDTVPASERPEPSPLTDYLAGMLRTPNQSHSLTPSDVEKSFDADRGLVTLVPPRDRSKIPRIRQRRHIWAHPASSTSSATQASESLPGSTAAIPKPVELTAQEGRIRWPLLWEQLGGDPTLVPSTQAQRDAVRWAEEDFMPGSTRHVGRLGRLMGEEEEMGAWQATAQNRARERRMQEQGEEFDSESDDEEEEVMGSVRPVSLGIPGTAAAPVSNPGSASVGVSTNAVSDSSLRQSTHTAPKRSQSQVEAEFEKRLLELFLDGLDTLDYDAVDFTPAEDPIADRDRTDAYFDDEAPSTAPGGSGNGHGEGDKVMENGQGEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKS6</accession>
    <name>K1VKS6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKS6"/>
    <dbReference type="HOGENOM" id="CLU_1788175_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKS6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="145" mass="15938" checksum="AB0D6F983259C433" modified="2012-11-28" version="1">MPLPPNEEDEKLILAGKRPPKLARKEAARLEHWNEENEAWQYTPGRFWPPGYGPYGREESEPAEGGGDGSEASRHDSNLAEGGAKKTEHAANARVATQKSERRRRRLNPQSNGGRAAPGPRNRNGRPDTEGVTARSGPVPIRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL48</accession>
    <name>K1VL48_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactinol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000315">
        <property type="protein sequence ID" value="EKD01476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL48"/>
    <dbReference type="STRING" id="1220162.K1VL48"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049943_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL48"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="347" mass="39376" checksum="476ECCD15A9F5CF0" modified="2012-11-28" version="1">MISSLFSLEPSSPSFISHFFHAQHVHFRREEGVGCSRHAPELRARYASQLILPLVLTSRPACAAPHALRCVEVPPRGARDLLTRTGPRVKNEAAFERFADTWTKLAVFGVEGYERLILVDADTIMLRGMDELFTMPLGEDWIGASPACTCNPFQFAHYPKDWIPENCSLSHQPRPTTLDNVPQPTKDSPRTAHLLNSGVVVLRPSKELMDSLAAHLDSDAVASAQFPDQDVLAEVFKGKWKVLPWWCNALKTLRAAHKNLWEDSEVRLLHYILDKPWSKRPQGYDYPTVESSDIELPKALVQAVKSAKPQESLQNYDGLHSWWWLVWDDVKGRLGDDRPLVEQWVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL67</accession>
    <name>K1VL67_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000352">
        <property type="protein sequence ID" value="EKD00022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL67"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491066_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL67"/>
    <dbReference type="OrthoDB" id="2594004at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853881" description="Heme haloperoxidase family profile domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="268"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="562" mass="61016" checksum="4E55CB63F2D615C7" modified="2012-11-28" version="1">MRVAAGLTLLTVVLPAIDAFPHMARSHGHAEPAAAMERDGVLDLFNPTKIIDNVQTIAEQFKLPDLDLPKLEGIDLSMLGHLGQDLDLNKIFKDGLDITRVDQSKLKEDLEKLDVFKIGDKFDLLKIGDFSGLHLGDNVDVSGVKAGVATLAGGNVTAGLGQIAQSSGGNVANGLQQLTQQTGSFLQQLAGEFKTFNPLTMGVFTLQLLAAQTKIRSDAKKNPKFTDFPKPQLLNTWQNELTKDMIYDAYNLHRPDDEDAWWGGGEDADHPYQAPGPDDQRGPCPGLNTLANHGYLPRNGLVTPYELMRGVWEGYSMSPELASLLVFSAFVMKGNLWTQKLSLGGGTLLSPGGVGISDHGFLEGDASVTRGDKVVGDQVHLNATRLEKFKAEIAQFGDNGDITPEVCAASRERAYRDSRAENPSFDFNPLRMLVAYAESGFAMEVFRGAHKRCTADTIDWFFAKERFPPGWKRRNIPLTSGEMLAWGMLFNKIRPVQSGYNVGGAFVPIPSIPGWTNFLSAGTVKMNACSLASMFITLLPAGVISFALGNGIGPVMQGLTCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL82</accession>
    <name>K1VL82_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_08181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000409">
        <property type="protein sequence ID" value="EKC97517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL82"/>
    <dbReference type="STRING" id="1220162.K1VL82"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_317403_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL82"/>
    <dbReference type="OMA" id="PFLGMYK"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="123"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="870"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC97517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="918" mass="97628" checksum="4F09D4C6D0688394" modified="2012-11-28" version="1">MRSDKVQQRKEDRTLSENSHANAQPPPPYTPAQSGVTAGSSTQPHFAAAASASDDVPWGTQVKDGKVQVDCDDISPPQPAGQGTVMPVGAGAMGLDNCPPLNVVMFVIGTRGELSYLLPSLQAGDVQPYIALALQLIASKGHRVRIATHAAFAELVTEASVCLAGLTDSKGVPLTGHLEHYDIGDKNPSIGTAPRGEQSNLVAKRKMTRQTLMGCYRACFMPCESTGVPFAADAIISNPAALGNIHIAEALGIPFNAVDANISVPPSASDTGQHARLADPGQLLQLHHGRYTRPSGRWEYPGHMLGAKVFYPDLMIGGDTLVPPSSRAPKISQELFEFLSDGPSPIYFGADTILAAVKETGVRAILHSTWTESEAPCGAVSKGVFIATAGCSPRAGYRPSATTEVSYQWRPADDEGAGTTAAGLKEGLPTVVIPFFGDQTMWGNAVHAAGAGPRPIPAERLTASRLVEAIRAVQSTEIRAGAVRLGKRLSRVNGAAAGAESFYRHLPLGNMILGIILINSAGPIEYNTAGYYRDPRESLDGTGSSIGTQEVSAKSQLYAPVCMKPQIVVWLIAQAKDFSNSLIGIPKASFDLVGQIQEGFDNVPGYFGSEVRRRGKVDSLRSGVKEGAKGFAYGLADGLSGLVMEPVKGAKEGPTAGLFRSARKTLARHGAVEARSVFCDAREHAAHAEAAKLGTQDRKELLAAWERVTGSYSIKQRMKEEKQRLASLDQHFRAGGSSSRSSNDGPERRSSWSSDVGHRGSLSSVMSRMKGKGKEKQQSDTSSNETATPARSVHSRTTSSNNPYQHEREQRIPGSYDSYITDEKYPSGASSSHTSPRGESSGLPQPRRDSRISLNSGMDVALAGTTDRWFGSTSSLGGLSTLTASVTGRSGREIREDPPITPEVRGRALRKGKEKEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLS3</accession>
    <name>K1VLS3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_05464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLS3"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_0_1_1"/>
    <dbReference type="InParanoid" id="K1VLS3"/>
    <dbReference type="OMA" id="MGAGEVC"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="47904" checksum="0BF0D328EF1EA38D" modified="2012-11-28" version="1">MVQDKYIGLALAFSSSAAIGSSFIITKKVRYIVAMTVARSDQAGTERCREATSRLPAQPPAADGAQECFRRSGVSPESDLVGGNDHDVANFAAYTFAPAILVTPLGAMSVIIGAILASFMLDEKLGRLGVCGCASCIIGSVIIVLHAPSDKEVETVDEILAYASKLPFLLYLGFVAVFSTFMIFRIVPRYGTKNPMVYLSICSLVGSVSVMAIKGFGIALKLTIAGNNQLTHISTYIFGVVVVSCILIQMNYFNKALDTFSTNVVNPIYYVFFTTATIVASAILFQGFNTTDAVNTISLLCGFLTIFMGVFLLNISRQPEVPHHTTSLETGLMNPRMSMSGRMSMEGQQGGATLWNYGNGGAVPPAYAEGGAANGHGRRSRLFQQQNSTLFNAFEEEGVALTQLQEEDESDDEEAQRRSSDQYKRSLVGRRGDVEGGRHPAYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VM43</accession>
    <name>K1VM43_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VM43"/>
    <dbReference type="HOGENOM" id="CLU_379997_0_0_1"/>
    <dbReference type="InParanoid" id="K1VM43"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="729" mass="80515" checksum="CF30415EF9954439" modified="2012-11-28" version="1">MDTKAAPSAPLSAPPLPPLPSSYRTARTNRTQQASRSCSRPESNNVPDPAPTRSPRSPRTSDVPLKMIVNPRPSLKSQQQHRPPTHAPPSSFRDSPTKQFDSSSVLPAMSGDSRLPRLTGNTPVRSKSMRVPTKAEAKEVPRPASELGYASTTGRSSPLPLLGINSRLDSLKDRQLSDVFKTQVVQAFSSPKDRDSASLGMREPPPTRTPSRLPSILIRRRATRSPSPKRLSNDLDQPIPKVVRTKTFGIPDDEDSPKALIHDHTGSHEGSPMTSHTETDASAAGVASTRVLHHPTYQMLSRQTMPVTARNLSASASSSESHLHTPPSEVVAQALSTHSDMLIQQSTLLAEVSQRFGQLAREALQWEGWLRQNLPKPHTEDKGVQASPGRTRTVSFQSSRKLDSNRDTLHSATSWDNLYKAEQAWDRAMKELNDVRGLLNELRRPSQVLSDEASCGSCSQDPILTRQDSKSYSQSSHLSPPPSELHGGFYRPESQHTFRLSKTHLTASPEQQAASLLFNPAESIDHTDIKSSEESLSSEWVCADVSAQVQTEKLHPNPNLSPATAESCRSEFQRRIASAAPSEENHIHKTTLTPVLEVDSLRFTVSRSSMRGALEPQSHSQPDLTSLSPGGSRNGSTHSHRHSIVHRSMPSVPSFQTMRLDHDSDRTVVWQQPGHYPDHHPEHRRSLVIGTKSEDPTIPERARSPPAEGAALLRTFSRRGRRWWRNIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMB3</accession>
    <name>K1VMB3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMB3"/>
    <dbReference type="eggNOG" id="ENOG502S7H6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130568_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMB3"/>
    <dbReference type="OMA" id="IFTISTW"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016540">
        <property type="entry name" value="UCP008459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008459">
        <property type="entry name" value="UCP008459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="1">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="165" mass="18337" checksum="E0479FBEF70C52C1" modified="2012-11-28" version="1">MAAPYQLDKKDKVLNILTLPEEVFVFRYAPTTPIPAGLWEGDEFCSVTKTKNELSIVAPQKRVVDSGMPKASAEHCGGPWNVLRVRGPLEHREYLAGSMAQWSVKSRDTLTPDMVGVMAELARVLKEASISIFTISTWDTDYLLVTKNTYEAAKKALEADGWTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMD4</accession>
    <name>K1VMD4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_07885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="AMBO01000401">
        <property type="protein sequence ID" value="EKC97882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMD4"/>
    <dbReference type="FunCoup" id="K1VMD4">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VMD4"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="InParanoid" id="K1VMD4"/>
    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="222"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC97882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="356" mass="40082" checksum="7DAD5012B083465C" modified="2012-11-28" version="1">MFGERPSQGTLLKAAQFLQEELPIRLSHRVVELESLPDGLSKMPSINRVKEWYAQSFEELITFPKPKLPADIEEILRMPPSQATTFPTAVANPSLDPLMNEGAISGSRINYSDTKRGRHHSIVNGGVRMRIPIERMYFSPPPVNVVYPPEVHDYNENFTRVLQTIKKRHDPTVTSVAQGVLEWKRKQKAGRIGQNIQEWLDRFYLSRIGIRALIGQPNARSHIVFELLKNSLRAVVERYGVDNEDQFPPVKVIVVEGGEDITIKISDEGGGIPRSALPMIWTYLYTTMSDEGLEDTIQEGIQGHTVPMAGFGYGLPLSRLYARYFGGDLRLISMEGHGTDVYISLNKLSSSREPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMR6</accession>
    <name>K1VMR6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMR6"/>
    <dbReference type="HOGENOM" id="CLU_1403349_0_0_1"/>
    <dbReference type="InParanoid" id="K1VMR6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="194" mass="22260" checksum="70973CB01F0E90E8" modified="2012-11-28" version="1">MPTYDSPPPTLLPAWEDAGAQPPPQAALESPTIMTNRDRACDTSARQAYPPQRIENLISNASTSINDMRNEIHALFEKKKERQGWNSLDEIRKLTEEREKANQALREQITELQESMALLKAKYAIYRPRGPEDYAWLREEKTPPHPFKSIVHDAVATRKGSDCSGLMQWTLEAVSCEAKPRDKEVWRKMQNKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN82</accession>
    <name>K1VN82_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_03608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="AMBO01000297">
        <property type="protein sequence ID" value="EKD02106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN82"/>
    <dbReference type="FunCoup" id="K1VN82">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VN82"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_1_1_1"/>
    <dbReference type="InParanoid" id="K1VN82"/>
    <dbReference type="OMA" id="WMQDAAD"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="167"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="598" mass="64880" checksum="99ED054BE9B66BC8" modified="2012-11-28" version="1">MLSRSPLRLFSRSFGGRVQPLKATKPIKARPVTSAAPAPSASSGSHHQGHHQHGNNQHQRWRFGRYAAVPLVVATGAVMTLRSRAKAEEPTSGGLSGISGVPASALVRAYLVYTLCGFPTLIDISPKLLDVCTKSPIPGVKQVTEAIIRRTFFDQFVAGEDIPECIRSVNELGARGIGGVLNYSAEAEHDDGKHGDSHRAAEDANYQESYHAIEALGRHEASLPPAAQGSASYAIKLSGLIDIDILERASNTLVRMRPLAGDKSLTDAPYPGVPQVCDAVVIAPSDTTSSRAMIPSVSGAIEPTGILASDPDVSDSDLAELKVFWEKMRRLSDLAADSNVRLMIDAEYAATQPAMDALTQLLSMEYNRPRPGKPYHGPIIFGTYQSYLRRAPHLLDSALKHAEENGYALGIKIVRGAYFVKERKRWLKDGRTGADPIWPDKPATDAAYNQSVSKIVSTLQRQLAGPRPDLALSVVFATHNPESVAHVTEELKRAGLAEPSAETEYTGRLRLRDDVRGRLFVAQLFGMRDDITDGVVQTFDSGAVPVALKYIAYGKLDEVLPFLARRAIENKAVMAGEGGASVERKRVSDELWRRLVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNI0</accession>
    <name>K1VNI0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase lambda</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNI0"/>
    <dbReference type="STRING" id="1220162.K1VNI0"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354876_0_0_1"/>
    <dbReference type="InParanoid" id="K1VNI0"/>
    <dbReference type="OMA" id="HEMSAPS"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="886"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="242"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="919" mass="100602" checksum="5F3F8B6998A3E549" modified="2012-11-28" version="1">MGQHDPFKTWGDDLWSKLDDLDGSDWWQDSAEEQQELAKRIRSIEGASAGPGARQHATETDVLNVSFRMSASNDHAPALPHDQRSSSRSLPSVSTKLPGNVPATPSDGRSLKGPNTPVVDTPPVPKSLPRPQPPLGTSASTPTVSTRPPTAFDTPDNVPTPTQTPSGLSVGRGRRDDPASPAPLGDDSTLKKVAYTKITNQFNEFNMKIIAAANRVGQGPTRGGRGKGLGRPIGLRSTRATPRSEVFKGLRFCMPPEGPHCGTKHGSRWSKIAEYGGSVVIQPDTAVTHVIWDHGGSASNLAKKLGLQTLSELPEGTVCVKWSWVVQCQLTVLDVTPYLTFPPTTLSKQPAGKGTRSRMSDITQQLTGSTKGGKRKYDSSDTETESSEPLTRHIKRSYNAYQSLMHATKSVPRLTAPKSSASAAPILPQPQTPIANANRSDQAPLATSHEVAAGPGWMQPASGEEDALDRLITGIKTGEVKEAEAGEDGADEVARYEGNPNPRADKFKCGQPSAGRKEGPNEALAKEFDKLHAIYKATPGKNEFSILQYSRGHPEQIKSGSQIRHLRSMKLLTGAKGRLYFEDTDQARTIAKFQNVYGVGSRCAHELYSRGARSIEDLATKDFGLTVGQKIGVKLYDDLCARIPREECRQLFEIVRDQTLSFDDKVFVEIMGSYRRGEANSGDIDILITRDPSDGKTHQGLIGKVVQALSEKKFITHALGAPNDWQDLECKWMGVCRLPNGIHRRIDILSIPWEQKGAALLYFTGNAIFNRSMRLYARKRGFSLNQRGLYRNVIRNRQSEKVTEGEIVASRTEEEIFDILEIRWRPPHLRRPAMAAHAHANRHARLVDARFSVSFDTHKIPRNRTPTADQAVEVNERDRRRKVSPWSLLLLLAGAAGTSKVVVVCVLAVVKVGSEACAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VNX7</accession>
    <name>K1VNX7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_07416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VNX7"/>
    <dbReference type="STRING" id="1220162.K1VNX7"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="InParanoid" id="K1VNX7"/>
    <dbReference type="OMA" id="CADRTKE"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000363">
        <property type="entry name" value="D-isomer specific 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="146"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC98402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="383" mass="41392" checksum="4367055E2AD9C436" modified="2012-11-28" version="1">MELGEHAVLAPEYISTALADTSSHSHLITESAIMTADTKLTLGCLIPISDSKLAELQSVANVHYWPDGKDVDRSKFPDIDVLFGIPDGVKDLSELPRLKHVQLCSSGSDGGQNWPPMAAVKNGERDVSLSTASGAHALTIPNYVTAMVLNIYHQIPKQILNAREKRTWTKDIDVYGRTYGIRQTRGRTAGLLGYGSLGRESARLLKALGFSIIAANTSGSARRQDGYIPPGGGDVEGKIPEKYYSTEDEEQVKDFLGQCDVLVASLPNTPKTRGFLTKERLGMLPPQAVLISVGRGNVATSEDILAALDAEDGLFGAALDVTDPEPLPDNHPLWTHPKVIVTPHCSGDPEGEMDITADVLMVNLDRLAKGEPVINRVDFKKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VP26</accession>
    <name>K1VP26_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000324">
        <property type="protein sequence ID" value="EKD01192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VP26"/>
    <dbReference type="HOGENOM" id="CLU_855777_0_0_1"/>
    <dbReference type="InParanoid" id="K1VP26"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD01192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="337" mass="37976" checksum="202C5075DC83B384" modified="2012-11-28" version="1">MPSLDYTSFPHLFEAVIDQLILERDHASLRAVYSTSHLAQHIVYEKVGRHQMIDFRVKPTRAGSTVGALWNPAHKFVKARGTVLDIYAGPEKSTYPLLPGFQRMVDAAAPDVVRLMDHYEYYESEDTLSSAKPIDTVVLQAQNWISNDSWNPLDDFWLPLLPPTAKRIVINIRGCAAYGFPVLQFRRNGYDPSAEQEVIILVSHDCTPPADTRVLRGTDDCLKILIESLGEGTFLLLRSQPKSTVLIVDAESSEMSLNRTPLTAQPSPLCLGMHVLSKMCERAMVYSAAGEWRPTFEEVESRCGRVTFDTVERFKDRVGEAMFRLMTEEDVYVGEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPE9</accession>
    <name>K1VPE9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000281">
        <property type="protein sequence ID" value="EKD02506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPE9"/>
    <dbReference type="HOGENOM" id="CLU_042189_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPE9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="501" mass="54519" checksum="5F922F72F218FB61" modified="2012-11-28" version="1">MWAIFALLGSALAVPLSVPLSPLSPIIAYDPITYNGNEADGWSWTIPKVEWKPPMLGDGAALNVSRSNAKFAANFTGTGMFLNGSATTNTTIIRMWDNKELTAKFEPYTFAGAYKVNLDADGHAFGKSMEHSWGLRLVNGSLAVDQIVVQTQIDAAYTAGREAPEINQQPVLNNTKQNPMFNWEGEWDWVQQFDPGRFDDKQPHARGKPGAQVWWHIPEGVAYMAIGGFVGYQGGTYEVELAPSPGNTTKWSYNASRPFELITQMFITPLDPKTRYTCWLRNTDKNATLQFRSARYKFTNQDAADKFEALSAQLPHEDKKKKNVGAIIGGVVGVALIALGIFLLLRRRKVEEPTWEERAQSDPGWRESLSSALSFDPKGRRPPPPRVQQESDAGTIVVPPSYDPAWAQTGGNPPPGGLSPASPETPNMSPSNMSAGTPASPSSTGEKLLTSSPDTSGVSSSGAENVSQRLNEKAQYVAEISAAEQGGQPPDNNGFKDEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQE5</accession>
    <name>K1VQE5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQE5"/>
    <dbReference type="STRING" id="1220162.K1VQE5"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855771_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQE5"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003853976" description="Fungal lipase-type domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD02851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="325" mass="34914" checksum="F2FDDBA022469D18" modified="2012-11-28" version="1">MIAALSLLAAALTALASPTPGPVPTGGLQERAPWNPTTKGPYSALSAEEYSSWNADARWAAWRTGAAATSAPRSPVGAASSSSSLAETTATSRTEAEEVRWHHMVLFPAAQRANLPDYVAQNASHVIVSMRGLNGQSAESWTNALGISYVTPDKAWFPGSPGKVHDGFYGVFKDVRAEVLKHVEAACEGGLKQVLVAGHSMGGAVGELLAVYLQKQLGVTVTAKMFGPARVGNQAWAKYVDATLPGRYAFMTIFDDIVPHLPPMWLDYRHPSNEVWMMHTDKPQEWRVCEGQENENCSDSISDKGEATITKAHVGPYAGIMMECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQJ2</accession>
    <name>K1VQJ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_02850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000274">
        <property type="protein sequence ID" value="EKD02906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQJ2"/>
    <dbReference type="STRING" id="1220162.K1VQJ2"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_1_2_1"/>
    <dbReference type="InParanoid" id="K1VQJ2"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF885">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD02906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="228" mass="25352" checksum="FC963B7B218E4E90" modified="2012-11-28" version="1">MTQDLSALPILDLGLLDSTPEDAARFRAQLAQATHEIGFFYLVNTSLPPSLEKRMHDAARAFFALPLEDKLAIANTNSAQFRGYTALGLERTRGQVDLREQIDICPEGVAFSEEELRGREKFWRLVGPNQWPAALPELRQVSEEWQAHCERISRKLLRAWALALGESEDYFERSFGDPFTLLKIVRYPPTSPSADSDGVQGVGKHKDAGVLTLLWIDGSGGLQVEKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRI8</accession>
    <name>K1VRI8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRI8"/>
    <dbReference type="FunCoup" id="K1VRI8">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRI8"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057568_1_0_1"/>
    <dbReference type="InParanoid" id="K1VRI8"/>
    <dbReference type="OMA" id="DHFAQKA"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31818" checksum="CC73E75F52A70407" modified="2012-11-28" version="1">MSAEPKTGGDDLDDGLELDPSLMASDDEGAELGEDEGAYLSDEEEAPEPVSRKRKAADSADSAEPVSEEQAKKDAKKRRREKDKARKAAKRAAEYTEPADPSTLSTEEFAQTLLASLRSTFPAGTAMEIEDRAIPTKHLLPPLMAVDGEGSDPLKARLTDALRNAPKKPTMGTPRVLILSLSGIRCADVVRAVRDVPRPGGEIAKHFKVADQVKFLGKTRVAIAVGTPARVAKLLEEGALKITPQTVVILDIGHRDAKNRTMLSLPEVRDEFWKSLLANKARRALLDGGAHFAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRL8</accession>
    <name>K1VRL8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_06284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000372">
        <property type="protein sequence ID" value="EKC99347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRL8"/>
    <dbReference type="FunCoup" id="K1VRL8">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VRL8"/>
    <dbReference type="eggNOG" id="KOG0796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030397_1_1_1"/>
    <dbReference type="InParanoid" id="K1VRL8"/>
    <dbReference type="OMA" id="PCTRIHD"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC99347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="347" mass="39986" checksum="95B8B0B4E99E3A60" modified="2012-11-28" version="1">MGFNPPNLDWWDAKVCRDYLFGTCLHDTFSNTKMDLGACPKTHSERILKQFKEAQAATPNDPRILQFKQEHEANIYQYVEECDRRIRASQRKLEKTPEENRKTIDLMKEIGEIELSIQNGTEEIEKLGEAGKIEESMERLEAVEALKQLKTDKEKELKILDENAGASGHQKLRVCEICGAMLSVLDSDKRLADHFGGKMHLGFHELRKLMAQWAEERMRGPPRTGPPPSSAPPPGPPPGRVPPFPISSHPDDPKREAGEVTEDPRDRGPAMRYDDRPPAGGDRYGERSDRYGDRERRDRYGGSSRYDDRDRERDRYGSSSRYDDRDRDRGHERRRSRSRSPSKRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS60</accession>
    <name>K1VS60_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Specific transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_02243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000248">
        <property type="protein sequence ID" value="EKD03436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS60"/>
    <dbReference type="eggNOG" id="KOG0958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238507_0_0_1"/>
    <dbReference type="InParanoid" id="K1VS60"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="447"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="694"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="623"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="926"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="941"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD03436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1784" mass="191331" checksum="713FED8117155191" modified="2012-11-28" version="1">MSSVSEPFPRSRSLEPRTHSLCCADSECPPGGPAGSHDPRPFPAPGAVVAPAPPLAPGRLGGPAAPPAPSAAGRAPQLPSFAPRYPGHYYPTGPSFPCANRVNIVDSRLDSGYPGHPGHGYPGPPPGPPPGPPAHLVSGPPPLQSPHPPPPHPGYHPNHHPHPAHNFYHPPPAHHHPPPPPPYPHHQHHHPFAHPHQPGGGWSRSESAVPPPRLPPPHLPAAHAHPPIGYPTTRVSLPPPPRPTTYVQHRTQGINIVPREMTTGPAPVPGTAASPTHGGEWIPDTVASRAAALAQAKAAQQAGVAVPTGVGKIMLGTDRQRILGKSLPPITVPAIHLSGTNGKGSTSALLESCLMAAGLKTGRWCLPRSTRRKQEPMAKTPPETPEEEPLDPFYEETDLSRAWLPEGVEPADYTVTGCAGIERKFWKQIGMSTPSWYGADLPGSLFADPSYPWNVANLPNMLNKLPRKLPGVNSPYLYFGMWRAAFSWHVEDMDLYSINYIHFGAPKFWYAVPQAKAERFESIAKTFFPTDANHCDQFMRHKSCTLSPTMLRDHGIPVNKLVHNQHEFVITFPRGYHAGFNLGFNCAERVNFALPNWLELGRKAKACTCVNFSVTIDVDYLTGDRPFTPESSDDEEEQERVAKRRKKEAPPPPPPVEEPAPVKLPIIRIKRPQQIVPLTPEPPQKPSVTREIPNYPCILCPSLVADDLARVFEPSEHLKSMTITPEVLAHSSCAVAIPEAYTEDVEVDGIMITYVKGLNDIGKDRWKLKCSACIDKRTARRGTKIQCTKGKCLRAYHVPCARENPEVHYFAGVKPASAAEGGTAAEGSEQAGGGEFAVELLCPTHNPAMIEVRKQRAEEQLYRKVHAVQPGGFIKFKKSGVSYAAELLEIKDETRRAVVRLPNLTVTEVAWNALDFRSHEIKMQENEYAGPPKRSRKDAQATAATTTTTTLPASPVSLPRSSAAPSAAPSAPPAPGEVTDTSSRHSGLATPVPSAQPQDPQELKEPMAAEDKEVTNPPSPHARSVDPHDPRARPLDSECPPGGPAGSHDPRPFPAPGAAVAPAPPLAPGRLGGPAAPAAPSAAGRAPQLPSFAPRYPGHYYPTGPSFPCANRVNIVDSRLDSGYPGHPGHGYPGPPPGPPPGPPAHLVSGPPPLQSLHPPPPHPGYHPNHHPHPAHNFYHPPPAHHHPPPPPPYPHHQHHHPFAHLHQPGGGWSRSESAVPPPRFPPPHLPAAHAHPPIGYPTTRVSLPPPPRPTTYVQHRTQGINLVPREMTTGPAPVPGTGTAASPTHGGEWIPDTVASRAAALAQAKAAQQAGVAVPTGVGKIMLGTDRQRILGKSLPPITVPAIHLSGTNGKGSTSALLESCLMAAGLKTGRYNSPHLVEPRDTCLFNGQVVSSEEYAENVAFVQAIADKEQLQSTTFEVSTWAFYRMCILRKVDVMIVECGIGGGRDATNILPKEIVLASGLSSVSLDHTAILGDTITEITSDKAQIAVEGGVLVSTPHQNPEATAKAKEVCAEKGALFVQAEQSTEVEAPGPIGLAPFTPPRPPLIRTPLKGSPKGAIETRLPLPGAHQLDNLSLALTILDYIRTDPRALNIQPKLRGLTDEAIQKGVASTQWRGRCSWLTFRGPKRPIPVLVDGAHNFDSSTTLQRYIDTLNLPAGAPRTFVLAMSASIGKSPDGVVRPLLQKGDRVAVPRFTAPVAGMPWITQTDTDKARDTVMPFIGEEGVFYEAKGMGAESVADALRWADEQQKETGFIVLCGSLYLVADAYRLLELQANESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSJ6</accession>
    <name>K1VSJ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSJ6"/>
    <dbReference type="STRING" id="1220162.K1VSJ6"/>
    <dbReference type="eggNOG" id="KOG1576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_7_2_1"/>
    <dbReference type="InParanoid" id="K1VSJ6"/>
    <dbReference type="OMA" id="PYYFPSE"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="414" mass="45593" checksum="0DDCECE1D887C56A" modified="2012-11-28" version="1">MSASSRPPNINMDLAPNHPHQPEEPIPPFPTDVDVPALDPSLKLPPKEGEYSDLLLGCATFGYGVYESKEHVRTNEPLKIVKTALDAGINGFDTSPHYHPSETILGHALASLRAQYPRESYKLLTKAGKYGPRLQDHVYSPDVIRASVERSLRRLQTSYLDVVYLHDCEFLSSFPFPMPAGDHSLALSSEAEAEAWGLAEPYNPRGEGDAAVLAAFQELRKMQKEGKIRACGLAGYPLPTLLRFCRMIKAQTGESVDVVQNYSHFTLQNSALEAYLPAFTSAGVRQVINAAPLSMGLLTTAGPPGWHPAVFVDHLRDSAREAAQLCKKEGGSIEEEGLRFGYKRLSMGERGKEKVVPCVIGCTTREQLIQTLQTFKKVRDGEERSELGDKVRGLLEERGALGVSWQKPAPEEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSR2</accession>
    <name>K1VSR2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSR2"/>
    <dbReference type="HOGENOM" id="CLU_1929079_0_0_1"/>
    <dbReference type="InParanoid" id="K1VSR2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854336" evidence="1">
        <location>
            <begin position="17"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="131" mass="14323" checksum="D8F46580BEEAFA58" modified="2012-11-28" version="1">MRFALLSLFAATAALAAPAGANPHSDIENVEIEPSEPYTCEYAHLSWEGGVPPYTIVVGDGEEMHQRGSIGKELDRFEVQDQFAAYRIKHEGHLEFAIYDSNGRRTTSGATAIRNAFTECIGKDDGLPSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTZ9</accession>
    <name>K1VTZ9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000237">
        <property type="protein sequence ID" value="EKD04026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTZ9"/>
    <dbReference type="FunCoup" id="K1VTZ9">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTZ9"/>
    <dbReference type="eggNOG" id="KOG4174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035438_1_1_1"/>
    <dbReference type="InParanoid" id="K1VTZ9"/>
    <dbReference type="OMA" id="YPGYKHA"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="108"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="375" mass="41051" checksum="C1882DB6FF3A1B92" modified="2012-11-28" version="1">MGKGGRLKGALGSYQAAAAKKAAEAKKAANAKAKANAPQMNEKAKRAAKRQRREREVAEAAARAEARNAKDKAAAARAGAAASTATAESSNAVLRKAIIPIKSDDTVLLLGEANFSFALALVKGRGHAGHLVCATSYDSEAQCYEKYPDGKENVDALREAGARVVFNVDAGALEKSKAIGKGRRWSRVIFNFPHCGSGMTDQNRNIRENQVMLLRSLRSVSNVLSDGPPEVEEKKKRKRKPQESDSESEAEDDFEGFDDDEDNMPKTKGYAPSSFTTPNRQGSFLITLLSQPPYSLWDVKGLATRPPPVCPGTREAQPRYTLKRSFEFVPAVWPGYAHRRTIGWREGLSKDDNEEIVGRIGKARTWEFVLREEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU53</accession>
    <name>K1VU53_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU53"/>
    <dbReference type="HOGENOM" id="CLU_1086605_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU53"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852103" evidence="1">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="256" mass="27290" checksum="9CD029FA5530078C" modified="2012-11-28" version="1">MLVVPLLPLAVAAGVVVASDVQQHFTFLSPTLDFAGEWETNNLNAFAQGGNVSVTVAGSGITFMAKSDAMSILVNGSQPAIPTNISKDYAEISHLPYGWYEFTLVSKGNCTFRTAQAVTDGERWAVNDTEPVNVVNASSVTTTGEWNKGTNRFSTNSTDAVLHIDVPIGTAMLELLVDVPSAPFGGFDVCISPPPPLSPAFETFMPNLQPADIQLMIGQLNVPVYSVLLDPGAKYSVSISITSTNLWAVSNVKYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU82</accession>
    <name>K1VU82_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VU82"/>
    <dbReference type="FunCoup" id="K1VU82">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU82"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025145_3_1_1"/>
    <dbReference type="InParanoid" id="K1VU82"/>
    <dbReference type="OMA" id="RPALMDK"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="437" mass="47493" checksum="C55607AD6DFBE981" modified="2012-11-28" version="1">MAPKDTIYYDLLEVKVDATPIELKKAYRKAAIKWHPDKNPSAEAETKFKEISEAYQVLSDPDSRAFYDKVGREAMNKPETQMEDPQEIFSKLFGGEAFMDYIGEIALVKDFTSTMDVVMTPEEKAAMEEAAKAEEAADTPASAAEIGKAADAATAGAAAAAAGTAAAGSTSPSKSSPEGSTTDLTQHTGKKEYKDAKGKTKLTPEQKAKLDELDIEDLTQKLIQRIRPYVDAKNPGDVNDPETKVFEQRIKTEAEDLKLESFGVEMLQTIGGVYLTRAGNFIKSKKFFGGGFFGRLKEKGGMVKEGWGLLGSAVGVQTAMAQMEKLEAAGTATPEEIAALAEELSGKMLLTTWRATRWEVINGISKDVALRRAKAIMTIGGIFKAVEADEDDEERRELERLVQNAAGKKKKHHKSRKGSPVAEPSTPEAITEKAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUD8</accession>
    <name>K1VUD8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUD8"/>
    <dbReference type="HOGENOM" id="CLU_2401240_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUD8"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="93" mass="9075" checksum="1A6900ACB711F7A8" modified="2012-11-28" version="1">MRLALLFTIACAAAAPIDIPIGAVLPGPLAGAVAMNPHRDAAAVPVSQDTTGGGPTSLESSGGGPSNNGLGLEQGGMRGVPEAIKNDMKQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUS1</accession>
    <name>K1VUS1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">A1Q2_02372</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUS1"/>
    <dbReference type="FunCoup" id="K1VUS1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VUS1"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_38_1_1"/>
    <dbReference type="InParanoid" id="K1VUS1"/>
    <dbReference type="OMA" id="INEESTW"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="19">
        <location>
            <begin position="261"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="801"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="18">
        <location>
            <begin position="1110"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="646"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="956"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EKD03262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1175" mass="134616" checksum="F273457654F77F0E" modified="2012-11-28" version="1">MYTRELLESCAKQVRFPQPTTRDTQENYSLVTVSVGISYVQERTRALLDCGALGDFVSRAFVERHAIPTLKKRRASRLKLADGSTPTTLDEEVILEVNLGGDFRPYRARFTVVPTLVQPVILGMPFFYKETPLIDWRTGSVAARPRSITERAQAREEEGGLRVPADPLPEGALEDGDTLIAVSWQEGDASGGRVTRAEYVPDYYHEFMDVFSEETASQLPPHRPFDHTIVLEEGKTLGYGPLYPISEKEAAELRAYLAEMQEKGFIVPSSSPAGSPILFVKKKDGSLRLCVDYRKLNAVTVKNRYPLPLIGDLLDQLRQAKVYSKIDLRGAYHLLRIAEGDEWKTAFRTKYGAFEYKVMPFGLTNAPASFQHLMNHIFRDMLDISVIVYLDDILIFSQNETEHRGHVREVLRRLRENNLSAKPEKCEFHTDRVEFLGFIVTPDGIEMDPGKVAGVVSWPTPTNLKELQSFLGFINFYRRFIHQFSMVARPLHELTRKEVPFEWTPARAAAFDELKTRITSAPILRHFNPDHETMVETDASDYALGAVLSQRGPGEEWRPVAFLSRGMTPPELNYPVHDKEFLAIFWSFNEWRHYLEGCNVRVEVLTDHRSLEYFLTTKQLNRRQARWAEFMADFHFQISYRPGAKATKPDALSRRADHRPGDTAATSLSRELNEHNHRPLLTDEQLILTLEDSGLWTDILEAQEDDQEARRLTDEGVLTRRPDEGLYYGERLYVPAALRPHVLADQHSTAAAGHPGIKGTRLNVKKLYWWPGWSTDSDEYVKGCIDCQRTKHSRTKATGLLRPLPVPDRAWVDISLDHLTGLGQSKGYDAVLVVVDRFTKMAVFVPCHKTDQAADFAGQFMRWVYPRFGLPDSIVSDRGPLFVSGFWDTLTELLGTKRKLSSAAHPQTDGQSEIVNQWLTQFLRIFSNYEQDDWADLLPQAEFAYNSTPHSAIGMTPFEAHSGRRPRRSFLEPPRSETRDGDPAAVNWYEEMTRVHQRVGEAIQRAQAEYKRQFDKGRREAPFKEGELVWLSGENIQRLRDVKKLDYKQLGPYRISEAVGPNAYRLELPAYLRVFNVFHSSLLKPFHKDTVTTRPPPRTKPAHPAPDDLYEVEDIVGRSRGRHPTNRRSVWLWEVKWKGYPSSRNTREPRESLEHLDAFQRFENARLASGKRPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW81</accession>
    <name>K1VW81_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNF1 family protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_02023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000242">
        <property type="protein sequence ID" value="EKD03677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="92"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD03677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="835" mass="90397" checksum="53C57633CE098162" modified="2012-11-28" version="1">MTRDSADGANDGDREHVSRVPITDLAAVEENLDLDENDLSRATTPVTSPQRTETTTTVERPYSAFGEGKKWFIVTLAAVGATTSPIGSNIFVPAIPTMSVAFGVSKAKINLTIAIYLPIFIGTILIFTLAGVGQALCPTNAYWLLLLMRIVQSSGASATIAIGAGVISDVARPQERGKYLGIFNTLSCFGPTLGPLLGGVFAGSLGWRSIFWFLVCMGGVILVPMVLEADASSNGSGVAIGGILTGLLMDKVYQKEKKRVGGDHRTHPEFRLEKVRLSFLPWHAGMLVISAIAMGWTMQEHVHVSVPLIFTFICGLGTSLLTTTTIYAIDLAPVEVGTVQPMFKAMGAGWMFVLLAGICVLVTPLPIMVARIGPRLRRERAEKAKRQEEELAQEREAAATAAEVQEEGDEKSKASDELTPAHVRIATHVQTREQVACKILPALHWDPNIAADWNATLDAVEAHKEVVILKAFAGAKVPGVVELVGVLEEGGWTMPNEAHLRPFFAKLLHTLHTMHQIGISHDDLKRANIMVEKCGTRIEPVLVDFGFSQFFPHGGHLLSLGGTFDYSCPEKIADRPYDPKANDVWSTGILMMKALGLGHPYLDGTDGDSDLGRMRIAAGTPRWRWTKEDRIPGGRGEVIMGMLEHNPSKRWTRWANMLYEWERGMELEWEDIQAAKLPAESKRSYHSHSERDPPFTCELEVLPGADFQAPKKNGTPGKYATPTKAAPKPATPRQSMTPLSRKDINTPLTPLTPVTPETPPPLYEAAPLLEKGRLKGMKGRGVPDTPARKTAATTGIAAAVAASKKSPTELKQVGSGGRRKLGQPVKVSLGLGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWJ6</accession>
    <name>K1VWJ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1220162.K1VWJ6"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365319_0_0_1"/>
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    <dbReference type="OrthoDB" id="10021397at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
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    </dbReference>
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            <end position="44"/>
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        </location>
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        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="89310" checksum="42293874927C685B" modified="2012-11-28" version="1">MFTLDQFLVTIAAPRIAAHFNALDRIAWLNIAFFIPCAAALLLYTQIMSIFPPRYVYLAALIIFMVGNAVSGSATSMTALLVGRAISALGGAGMWNYILASVFGPLIGGGLTDLGASWGWRWCFYVYLPICGATLLALAVFLPSTPLVSPFDGQEDTRPRWKRALSIDYLSFALTLSFLVCFCFALQWGGVTRSWNDPNVVVALVFSGVLFAALIAWSYFRGPKAMIPMSLFRSVHFNGAIWVAFFGYSLVVVILFYLSIYFQSSRGTSATKAGVLLLGIQCAVSPVLILAGKFGERTGYAKVPIVIGCILTAIVTGIMSTYKATTSLATVVGLEILAGVGLGLILNLIVVLMQAKYYRNPHLTPHATNVFNLHNTVNYTALRSETKTAVLASPLVMWDNSGLLSERNLRFMQETYADAIHNVWWLCLAMALCCGYAAMAMRNLNLDDSQDDGQPSVAASCAASVYTTEVRSPFEKEDARSLIRYSAPPGSFKPGKPASQRSSVQRSSIQRSSIQPSVQRSSLQPSVARSSMQRSSLRSGSRRASPPPPVPPLPDMSSLSSAAAKTPSTVNSALPWGQQASSTPRASPVPPSPIPPSPVPPSPVARSPVPPSPAPSTPKSLPLPFPEMPEPVYMTPKTMSSQEAEELPSADDSSMALPDVRSFTPLDTNKILSLHESLHGDYSPNGSTERLRMSDRYPDVSPRTSFERASVERFERPSLETLERPSLEGRSLPAVPTPSSSTTSLSSATVKGPRPQPTTPSDKPSGPDSSTTSLTSGTVGGPRPSPASNRSVGGPRALGGPRPLPKSPLPPVPTQTRTSIDQTKAESRASNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWM9</accession>
    <name>K1VWM9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000185">
        <property type="protein sequence ID" value="EKD04941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWM9"/>
    <dbReference type="STRING" id="1220162.K1VWM9"/>
    <dbReference type="eggNOG" id="ENOG502S342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048444_1_0_1"/>
    <dbReference type="InParanoid" id="K1VWM9"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32975" checksum="15B998D294512E95" modified="2012-11-28" version="1">MSDEDNQNPLHTMDFPSLDLGHAACSQRTVDLGDMEVYVYGLDEISNSNKDIAAVASQMSNMAHGLIGEIRRFPAERDVIVLTLDQRGHGKRRDKDKPDPLWWYDNPGVLVNMITFLQGAVQDHKLIIDNIEQYLFPHGERRITEWMTCGVSLGGHVNWRMLLEEPRVRVAIPIASVPSDALHKLQIGRFVQEHALGTEVHYPPATQRYYNTPVPEGTYVGKKILAINGMGDDLCPPELGDPEWGRVVAEAGPGNAVRVTVQDVGHIVTPPMVRKSAEWLYRWGVRGVGEDTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWS5</accession>
    <name>K1VWS5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000177">
        <property type="protein sequence ID" value="EKD04976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWS5"/>
    <dbReference type="HOGENOM" id="CLU_662553_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWS5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="351" mass="39463" checksum="15CC2C9D2BBB276F" modified="2012-11-28" version="1">MSLASRSTPISYLFYPHIVDEVLSYCDYTTLLRFRATCRSLKALAHRALHDGHLTIGVEGSFIDLKFFADEFDPCQPPPPPCQTPTVVMRGAMGVLPFRLEADWTWACEHSREVDIDGACLSMSTHIVPDPTQGFRMCQPKPHKDTENLPNPSTFGSVTIQAGLLRALSRTPRTSSATITHSYQHGPPAYLPPTESLTLRTDPLCDCLVVKFRLRPELQPQHSAKHITLRVPDAWNGEDHMACCCNLAFALLQPSVERLTLSIDRTLSTFQKHEYSQDFGFILYELEERGSRGNIKSIEVELRPRKPGSMDEVLAEQIKAQCAQRCHVDSDEVHIVYSPTAGDPRPYTRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWZ2</accession>
    <name>K1VWZ2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWZ2"/>
    <dbReference type="STRING" id="1220162.K1VWZ2"/>
    <dbReference type="eggNOG" id="ENOG502RB9F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431610_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWZ2"/>
    <dbReference type="OMA" id="EYPRRIH"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="594" mass="64805" checksum="F8FBBF5D1AD02E06" modified="2012-11-28" version="1">MSGGVGGRGGDELPSSTQPRRRPSTSMLTNQSPPRLRTMPDQRWSPEPRRISYPQEGASSGRSSAPRVHSVSPDIRREPLLPPAAISPPPHRRSSREPPRSTSSSVPSYYDERYLGRARDYPEPAIPDRLERSGEASSGPPGAPAATPNPQPVGNSARARSPRRASTFPGLEQSYGPSSSQHGARERQVSGYGASSAAVPMPGSEISGGRGRYDRGPRASFPQERPRAFFTPLATAHRDLSTWPRDLVDTYRLGWEDAMAAVAEGQFHIDDVVHHRVPLWPPPGRPTSQPRPPTAHDPELEREAKRDLERRSRDRELETLPYPANKEPRLSPARSMVAHPSAYPSAPPPYPPYAHPHSHSGAQVGSGPGPIPDYAPPYPPATAPYPYPYTGGHYPPSGPYDHPSYGPHVMPGGMYGGPGAGAYSRASEQPTPHLRNRQMISCHPCRSRKVKCSGGHPCEACIKIKKTSECEYEKTVRRRGKGKKSLMGESEWQSESQRREGGRGDGGSEEEGGEGERRPSGATTSQATSVTSKPSRQSSERNERHEVAEAPHDDDNEGSPERSNQPRGTKRSRSDSRSKPPTSSRRGPSQSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX44</accession>
    <name>K1VX44_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX44"/>
    <dbReference type="STRING" id="1220162.K1VX44"/>
    <dbReference type="HOGENOM" id="CLU_070148_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX44"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="341" mass="35206" checksum="9C8A6BE9FCE9F993" modified="2012-11-28" version="1">MSGVRSQGDSEPPEPSSRSAPAYPLALLRTCVPRRALVTPEPWASLSPAAVRPSLRLCRLSSRQDSPGSLSPAGSITAAHPLVGQTSWLLVLADSKLSFAIASFLIRNPSIHTMTTVTAYFLAAAALAAQEAAAYSYGYCYDRYGRECFRLLLADKKQVSTAAAAASRTARASVSESASVSASSSSSCSLADAASAGDRIKKQFQQYRPPPPLPMQQSDNPYANNPPPPTDGTYGSYSQYGGAGPTEPETAYTGDGKATAGAGEAASYYGSAANPSNNYTTPASNNLESHSYEYEQAAANGQTPAAPPPAYGTNSGQGFAPPAGPPPGQSYAPPSGPPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXD0</accession>
    <name>K1VXD0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_00542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000142">
        <property type="protein sequence ID" value="EKD05156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXD0"/>
    <dbReference type="FunCoup" id="K1VXD0">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VXD0"/>
    <dbReference type="eggNOG" id="KOG1563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047737_4_2_1"/>
    <dbReference type="InParanoid" id="K1VXD0"/>
    <dbReference type="OMA" id="QYAFTWY"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD05156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="252" mass="27817" checksum="5D2BA6AF2F5284EA" modified="2012-11-28" version="1">MSRPFMFSALRGAFRPRAAGTGFAGASFRFQQRRNAGTITSTSLKSTIFRPITLVLLIAPLLTGYLGVWQVQRLKWKLALIDEVEHNLSKDPLPLPGKVNMNALPDFAFRRVLVRGKFTGPPILQGPQTRDGVAGYHLILPFNRSEHGGSTILVNRGFIKTAEGDEIRRGQRPVPGLGPNGEPGPEVVVEGMITKIDPAAKSYFTPENKPEQGDWFWKDIPTMTEFAGGEQNGVQPVLIDVIDSELNRNRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXE6</accession>
    <name>K1VXE6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_00411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000140">
        <property type="protein sequence ID" value="EKD05181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXE6"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618452_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXE6"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="150"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD05181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="443" mass="48488" checksum="B22BBA599309E56D" modified="2012-11-28" version="1">MPRDTDLDAEAARLSKLDKEVHPEAVLDAMGESVAPEKPAHSPFVGFAAGLLSGWTKLIVGHPFDTIKTRLQCAPKGYYKGAGDCFLSTVRREGPLALYKGASVPAVSWGITDSILMGSLHNYRACLKDWGILTEWAPSPDGGPSSEKRLSIAGHALAGLMAGWTNASVAHPTETIKCKLQLQLVQPEHVPKQYKGPVDVVRQTIAAQGITGMWRGLPASFMYRSCFAAMFGGSAECKELRANFRRLRGLQPPLRELEGHLVGIIARTRQLPGRRPRKQHVLVRRAANGQHQEPHHGRLADKAEISLRPWSVQDGVARDVRSESRAWVEFSGEVEEFLQGEFTRVGVGCGVWGVGCFWAVVRVGQLEGEQVGSQSGERSRGTSCETNTVADFTGIRARRIARFPHECGRARRVGGNNALGHKVRVHTLGTWAILGNHRSARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VXH9</accession>
    <name>K1VXH9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_01533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000233">
        <property type="protein sequence ID" value="EKD04187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VXH9"/>
    <dbReference type="HOGENOM" id="CLU_2211809_0_0_1"/>
    <dbReference type="InParanoid" id="K1VXH9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD04187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="107" mass="12379" checksum="3F1A81982BB714BF" modified="2012-11-28" version="1">MPLMTVAITCHDPMPDRIAGPFMRAFLPALRQWGAPLHDVGLDWRKTPDGQVFSVYMDRANAETCIAVGNNFMNWLQGTPFAHYKEWSWTYFPTEQAATRLMTFTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYB0</accession>
    <name>K1VYB0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_04049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="AMBO01000312">
        <property type="protein sequence ID" value="EKD01678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYB0"/>
    <dbReference type="STRING" id="1220162.K1VYB0"/>
    <dbReference type="MEROPS" id="S10.A66"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073758_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYB0"/>
    <dbReference type="OMA" id="FTITHAD"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006526914" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD01678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="274" mass="29857" checksum="E371C56A8FDCBAC2" modified="2012-11-28" version="1">MRLTAAALPALLPLASAFILPGPEDAFNLASDFLGHNEVPDTVLSPASDVTLSSIGSEEFFTITHADHPNHKVRIKQTDGWCDPDVRSWTGYLDVTDDKSLFFYFFESRNKPKEDPVLMWINGGPGCSSSMGLFMELGPCAVADGEPKSVNDTKVNPWSWNKEANVFFLDEPVGVGFSTFRHGQMVDTAEKAGQDVAAFVEIEFQGRDFHMAGESYGGRYLPVFASAVHDNNAKLVAKKKTPVNLKSVMIGNGITSFSDSVREANISNARSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYD1</accession>
    <name>K1VYD1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYD1"/>
    <dbReference type="HOGENOM" id="CLU_073667_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYD1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="340" mass="39042" checksum="B5C7F60D95D0E52F" modified="2012-11-28" version="1">MATLDILVFPHILDDVLHQLHLDGQFQTLARCRATCSTVKDVIDLRIPKLIIILQSDSFPDGYTRGSGKEPQRLLFVGKQIRLWPSCTEGWTRSPFDQVVDLHPRRAGMATSLPIKPRWEAPRRVPVLRLLDFDCRRPLPPCSADTLIIFPTSSSHPAVSIHSHIHLPRDAHRIVIHLPYNPSRLFIDYRSDCSFSYKFAPQSQAYSPQYRDVVQQCQEVILVLPNTPEDVVTRDLPNLPCWAKSVLQAVYHNSALQVTVLADKWDWQWLIDDRCPEEPWLQTITDHSKRLELAWGSCWARDIAAEFPLTGSVLDRVKCMTKAEYEAHVGSRMLRLMLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYI4</accession>
    <name>K1VYI4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000310">
        <property type="protein sequence ID" value="EKD01803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYI4"/>
    <dbReference type="HOGENOM" id="CLU_863786_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYI4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="322" mass="34394" checksum="D1D882004DBEE53D" modified="2012-11-28" version="1">MLYLIPLVAALAFAAPVDQPGAAVQAKVGDARVAAAWDPTFGLEKAADSAVAAAGQALEFAPKFGLDKTHQARDLEALAQLAAEAADKFWGSVPKVISEIEDKVKEIKAAFKAKIDALDSAIGKKWADKIKAIEDKLKALKDAKDKIDAAAVEAIQAEIKGLEDLIKADKDFFDATIGQAIKDKINAIEAGIGAIAGLFHLPKRSFDDDLAAAAPKLGEIFQKLEQAFANGDANAEKAIQEIDNAFKNPGEIAPKLAQVVDSIGKQVDSALQGRPIYVPSDWNKGGKLRQRDEDEEETEEDEGDEGEDDGEDDDEEDDGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYS5</accession>
    <name>K1VYS5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000304">
        <property type="protein sequence ID" value="EKD01933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYS5"/>
    <dbReference type="FunCoup" id="K1VYS5">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYS5"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072435_0_1_1"/>
    <dbReference type="InParanoid" id="K1VYS5"/>
    <dbReference type="OMA" id="INEQIVM"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="272" mass="30230" checksum="4D798233B7902C21" modified="2012-11-28" version="1">MNHQQHPAAWGQPLTAHQQFDMYSTIPVGRAPPVAHAEPVSHTHHWTEVQGRRDACSGQPWWVLVASPTSQLTPASYGSLARFRDIERLKALGTHTVLGAAGDMSDFQREEETLKLSDNHPALAPRNLYTFLANLFYARRSKINPLWNACIIGGWDFEKDEPFLGYVDLLGTTYTAPTLATGFGMHLAQPPLREAYEAKAGIDGKGDLLTEAEAEAVLNECMKVLYYRDARSMNKYQLAKVTKEGVKISDSKSAETYWGFAEGLRGYGSQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYV6</accession>
    <name>K1VYV6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA (Cytosine-5-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_03668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD01968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYV6"/>
    <dbReference type="FunCoup" id="K1VYV6">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VYV6"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_4_2_1"/>
    <dbReference type="InParanoid" id="K1VYV6"/>
    <dbReference type="OMA" id="QLFTEYV"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="690"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="746" mass="83521" checksum="9CE2C3E59F0CC860" modified="2012-11-28" version="1">MGRRKGASAWKNAEPRQNRTNGPRWNDITPDKMVNEQFEEYYKKIVPEDEWDQFMDTLKVELPTTFRVTGSRAHADVINNQIKDLYVPTMQNVELDGVKYDPPKPIPWYPEQLAWEIAAPKRVVRKSEPFKQFQRFLVGETEVGNLSRQEAVSMIPPLLMDVEPHHVCLDMCAAPGSKTAQIIEALNPHHTESTGMLIANDADYKRTHMLVHQTGRMPSKGLIVVNNDATQFPNISLGPGAGNIKYDRILADVPCSGDGTMRKNLEIWKKWAPFDGNSLHTVQLRILERAMNMLKPGGRLVYSTCSFNPSENEAVVAAALNTHPDFEIVDVADKLPELKRRPGIHEWKVATRDKDENIKWHESHEAYEAYASESGSERDNKSPLPASCWAPANAAELHLERALRLLPHDQNTGGFFVCVLEKKGTSEPTVVPASSLVKREVKSKFEEKEEEAVAVPAKRELSPSAEESEAKKLKSDAPQEPQDKKAKRDLAFREDPFGFVDPSHPELETVKKWFGMTPDFPAENLLVRNEYGNPLRTIYIVNDLVKAVILNNDYTRLRMISAGVKAFIRQDSQSRSDIQCKWRVSSDGILGVVRYVPEDKIVKAGIQELRTFLEEMYPPVAKFEGAFRDTCEAAEFGNMLVLFEAGEGAGGKLNLPLYLPCWKAKSSMSLLIDKREKSVLSNRVFGEDICKPAPPPRSREEKEAEAAAAAKEAADKGMPVPTPLETPAMSTEATPAPTDEEAAMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>K1W1C9</accession>
    <name>K1W1C9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_02878</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="AMBO01000276">
        <property type="protein sequence ID" value="EKD02803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W1C9"/>
    <dbReference type="STRING" id="1220162.K1W1C9"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007529_1_0_1"/>
    <dbReference type="InParanoid" id="K1W1C9"/>
    <dbReference type="OMA" id="FRTHQKE"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="199"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="391"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="754"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD02803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="929" mass="102508" checksum="7B152849DE4489D3" modified="2012-11-28" version="1">MSRTTGSYPSPLSASTDRGVRSHHPSSDPPAPTKQSPEVVQHGHPVAGPSRRSRLVPASPPPDIDDFDIEEAEGDVTDVEELVPPSSPPLPKSAPAPRTPRRLAPQPSVEAQAEEAMQGVDLDAIWSPSPSPSRSPPPPSEFPGRPARNLVSAPTSTSRASDPTAGVSDAGALTPRVHQIEKQFAWSKEVNQKLRQVFMLPNFRTHQKEAIDETMAGRDDQLPAICSQGKTRGVTFVVSPLISLINDQTRHLIKRNIPAIAYTGDLTQADKNIAHAELDRPVPYTKVVYVTPEMLSMGSRIQGILRGLEQRKQLARFVIDEAHCVSGWGHDLGDLRKDYPGIPIMALTATAPEKVQDDIIRVLGIRGCTVLKQSFNRPNLHYEVRPKQKNVLEKIVNFIKTQTQGVSGIVYCSSREKCEIIAKELRDKDIRAWHYHAGMTKGDRRKIQEGWQEHKFEVIVATIAFGMGIDKPDVRYVIHHSLPRSLEGYYQETGRAGRDGKNSTCILYYTYADSKTVLNLINNDQNLSRPQKERQTDALKEVLRFCHNKTDCRRTQILAFFNESFNAANCNQGCDVCMDREKNNIVVEDVSADARAVVEMMKAFSSSDRITIINAADCYRGAKGTAGKDLDRNPHHGAGQHWGRGDAERLIQNLVIEGCLKEYIIANRNGWSSAYVTLGPHAQDFVNGRRKLMMDFSQPAALKAKKAAKASAGTATGTTGQARVVPLAQLKQSKQPVSNPLSRKRSRQQIIEEEQAFDDSAWPSDDDYSPGEEPAVSGATVAGTSTKKRKSTGNDGSTGNDGPPDLEQQCFSELQALKSKLPCLRLQSTYASQHGFPLSDELLQMLAAIMPTNMPALRQVEGLPAGLLKVRFEHPLHCMRTHPRHMGCWAASGSGTERECEAYAHHQDYGTMILGITVKYHEQRSGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1W2B5</accession>
    <name>K1W2B5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W2B5"/>
    <dbReference type="HOGENOM" id="CLU_861033_0_0_1"/>
    <dbReference type="InParanoid" id="K1W2B5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="312" mass="35816" checksum="AA44D239436B41B1" modified="2012-11-28" version="1">MVSTFNIYDYPHIFALVGAYCDNETRFKLRLLCKAARYEINRNNDCHLLVTVVVNKLVLYSYKPDPDTRYLMPPMKHRLTRYLDKCLASPTPKIRAAFGYPRLIKVPCETLEFLYASYGRLSYHRKLGKKGSKVKTVALMPPPLLEPIREDCILELSHFAPDENCCQLHNSLLLPHVHELRFQYWREDRGGCTCASVELVHRATILRLSMNETTYFCGVVAAAFGPTVEELRLVVMTAESATAYLKTIKSKPRHTNLKVWVTCFENLCSGGVKRFRNEWTNMLDVPVALRVQEGGCSEADGWARPFLITEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1W322</accession>
    <name>K1W322_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">threonine ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_02408</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="6"/>
    <dbReference type="EMBL" id="AMBO01000260">
        <property type="protein sequence ID" value="EKD03298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W322"/>
    <dbReference type="STRING" id="1220162.K1W322"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_0_1_1"/>
    <dbReference type="InParanoid" id="K1W322"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="127"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD03298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="211" mass="23781" checksum="7E194A37990D587C" modified="2012-11-28" version="1">MNFSRLRFVAERAEIGEGREVLMAFKVPERPGSFVKLHNILVPRAVTEFSYRYSEPEHGWIICSFYLVSKSGPEGGISPSDRQREISEIVSQLKDLGIDSLDLSENEFAKSHIRHLVGGRSRVDNERIFRFEFPERPGALSRFLGSLTPGWNISLFHYRNHGADVGKVLVGLQPPPNGDADHSQLDAFLEELGYPVVEETNNGAYKMFLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1W3F3</accession>
    <name>K1W3F3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_02273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000250">
        <property type="protein sequence ID" value="EKD03418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W3F3"/>
    <dbReference type="FunCoup" id="K1W3F3">
        <property type="interactions" value="743"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1W3F3"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041451_2_1_1"/>
    <dbReference type="InParanoid" id="K1W3F3"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD03418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="348" mass="37755" checksum="53BE41A591F88BA7" modified="2012-11-28" version="1">MSAPAIDLKKPEPKPEEPQEEQGLTNDVITKYTTAGQALNTVLKKLVPEIQPGKKVLDLCVEGDKLVSEATASLYNKAKNGVKVPKGSAFPTCISVNNIVSHVSPLHSDPEIVLKDGDVVKVQVGIQIDGYAVTHAETIILGKADPVAADVVKAAYDAAQAAMRAVKAGNKNWDVTEIVDKVAKEYDCVPVQGMLSCQHEQNVTDGKKRILLNPSPELRRDHDTVTFEEGEVYGVDVLVVSGSDPKARPDESRTSVYKRANDVNYQLKMKTSRATFSEIQKKSGAFPFTLRALDDEKRSRMGVQEAVAHASDKVKSDKSIKDEELQKTISAPLRASKKKNKNAAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4G0</accession>
    <name>K1W4G0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000241">
        <property type="protein sequence ID" value="EKD03748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4G0"/>
    <dbReference type="STRING" id="1220162.K1W4G0"/>
    <dbReference type="HOGENOM" id="CLU_1225528_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4G0"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="24817" checksum="CDECA2DE18498DFA" modified="2012-11-28" version="1">MVTITRLQPKGTLEETYNSPEVKNAAKTLEVSFSTDDVTKALNGDDPNIGGLRMLASTTTAVMDLEAYVANPDGVDPAEVAGAVMLMKQPGIEHGKSENAKGPHSAKCDVIMEQKPELQKAFKDIIAFFGHLEEKALGPEAVTPTYYISHLGTLPDYQRKGLAGALLNMAKQKAKSEGKTLTLLTMTEPNVKYYEKFGFKNLYYEEVTLNGILTRWWVMAVDPKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1W4L1</accession>
    <name>K1W4L1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_01821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W4L1"/>
    <dbReference type="STRING" id="1220162.K1W4L1"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433599_0_0_1"/>
    <dbReference type="InParanoid" id="K1W4L1"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2 4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="40"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="622" mass="69608" checksum="219EC50D3DB7C750" modified="2012-11-28" version="1">MSTAVVLHERRRERRSCVRYPVRSVSETAKSLLPQLKDLDSTTIAVLSALGGTALTLGALTLGKRWKRIRNADGVPPRLLDNQGSIVGVVTRLYHTPGPFWRGPLKLRKVPTAPKDLKNETLSVRIAGVDAPELAHFGNPAQPHGKESLEWLTKTVLGKRLRVQVLRRDYTCPFEADKQVGIPYITRWILPDKPLPLMMLKEGQAVVYEAGGAEYGKWGLEKMKQIEDEARRGLWGAKRIELPGDYKKRYATTIASVRGKPTDEILEELENSGDAAIRAQIDFAREHERRTTPSTAASTLTRGERAESRAETRSDSRAESRTESRATDRDRERVRRERERESRPSSSGSYRDRERDRERERERERERDRGERPRSDSLRHREREREPQTRVTVEVEVDGHAVTGTSATTSRPPPPARQLEGVPLAVQEAWICEDLMFVLQGVEGELIRYAEGYDPMDVEQRLQGARWQVDQTLATFFTSVEASIELRNSPEYGMVGHALSAGIRGMLKEYRVLTAQLESLFLTSPTFTLQTLYFHLHPTLHTMSLLSSLCTALETDEKPNDDDASDDDDDGLGGMAEELGLGGALGLMRNLKAQEGLINGGGLVVGGEVLGIICEREATMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1W6D3</accession>
    <name>K1W6D3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative salivary secreted peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000224">
        <property type="protein sequence ID" value="EKD04478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W6D3"/>
    <dbReference type="STRING" id="1220162.K1W6D3"/>
    <dbReference type="HOGENOM" id="CLU_1760077_0_0_1"/>
    <dbReference type="InParanoid" id="K1W6D3"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010711">
        <property type="entry name" value="PLA2G12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824">
        <property type="entry name" value="GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824:SF8">
        <property type="entry name" value="GXIVSPLA2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06951">
        <property type="entry name" value="PLA2G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852663" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="148" mass="15670" checksum="4D2A50672FF7F5D7" modified="2012-11-28" version="1">MRPFFATIFFLTVGGVMAAPAPATGDACLGSIEERDLAPRGNPARCPSGKTAKSRGLTPATNGCSFVPEYKFHSCCNSHDICYGTCSRTKASCDTSFHTCMKNVCTATYSAGIKRTACLAAAATYYKGVDIAGDNAFENASEKYCRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1W872</accession>
    <name>K1W872_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000147">
        <property type="protein sequence ID" value="EKD05048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1W872"/>
    <dbReference type="STRING" id="1220162.K1W872"/>
    <dbReference type="HOGENOM" id="CLU_1338371_0_0_1"/>
    <dbReference type="InParanoid" id="K1W872"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD05048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="208" mass="22655" checksum="E4B3ECE28ADD0AC1" modified="2012-11-28" version="1">MDSSPASSTPPSPATPVTPRTPATPGTPQDRSASSHKEAMSPLMSNLNRLSNATSRPNFPPLQNTGSYASRASRSFSKSFSYWSGYGTPVDDDADEQATPIDTSFGSTSVDMTKVLYPTLENHPSPLEHPLLVLDLAELTSVPASVTNDELLSALLRRLEPWVGEDDDGAYCLVILAADDRDMPGKGKARSLPGVTWWLWNWRRIPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1WBS2</accession>
    <name>K1WBS2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_06517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000375">
        <property type="protein sequence ID" value="EKC99113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WBS2"/>
    <dbReference type="STRING" id="1220162.K1WBS2"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="K1WBS2"/>
    <dbReference type="OMA" id="NAGHECI"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKC99113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="559" mass="59721" checksum="0C2825027D2E354E" modified="2012-11-28" version="1">MTLTTQEASQRKLADLNALVSDAEALLGPAPAGDKAILAANYHGEQLKLTDRTADIVANIKARKEGWSSEAVTAAFIRAACAAHRKTNCLTEALEAARAVDKELATGVDASKLGPFYGLPSSFKAGEGAWLANPQLVKLFRAGGGIPFCKTGVPQTLLAFECSNPVFGTTTNPYDSSRTCGGSSGGEAALVTLRGTPVGWGSDIGGSLRIPALYSGCCGLKPTVGRWALLGNRPVVRGQEGILPTTGPMAANVDDLIYASKAMMDLTTRALEDGKMAAEGLLPIPWREKTLPKRMKIGYYRETGVVRTSPALLRALDITIVKLRAEGHEVVEWDPPALWKVFEVFAALTSADGYRQLLANIGPDPKEPSLALVTAGSSVPRWLLSLATGLVKNVLGDETFAHVMATSHAKSASELFEWVAQRNKLNKEFKTKAWEQQGFDFVLGPPQAVPALEHGRTKMLSPLCIGTCVWNVLDTTAGVIPVTRVRKDLDAVPEGWLEIGEGEARSSILEKRVYGGSDPAYDAGKMEGLPVGVQIVGRQWDEEGVLAAMKLVEGLVDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1WDI9</accession>
    <name>K1WDI9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_06077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000367">
        <property type="protein sequence ID" value="EKC99658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WDI9"/>
    <dbReference type="STRING" id="1220162.K1WDI9"/>
    <dbReference type="eggNOG" id="KOG3362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2198834_0_0_1"/>
    <dbReference type="InParanoid" id="K1WDI9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="108" mass="11545" checksum="80C9D4DBEA16CF33" modified="2012-11-28" version="1">MAITTDFQQRRVQRRLEDLESFVPPPPPPGSAAAQTHAAQVLAAKKKQTPNVRRALGTKKTFRDWLGELPSTPTPPYVTAAAPPPATPPARLLECVAIHERDGGCGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WE42</accession>
    <name>K1WE42_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000358">
        <property type="protein sequence ID" value="EKC99888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WE42"/>
    <dbReference type="eggNOG" id="ENOG502RB8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_858387_0_0_1"/>
    <dbReference type="InParanoid" id="K1WE42"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="324" mass="35235" checksum="38B2A02C178FE0E1" modified="2012-11-28" version="1">MASPLHKWLFSPPLSPADYSLPSHVKPLDASSVFSSSLVNVESQRSRNNARMTGRGHSVLAGMKPIDIEAANASGEYPEKRSPVMLSPLFSPMLKAKVAHYVPRPVQRLLAVLAAFLFFATVSKYTTSLAAASAHRAAERNYVPPQAVRAPAHPRANRPDPHPLPPSHELLALQSFILESSHATLAPAVDGSKPLDAVMLLGSPGARRLGGTDSAQERAWLQSLSDENSAKVVLWYNAERPPHYALEGVTARHGQGRRASMINTRKRRDGDTVNAVLKRLGHDLSRNPILVVGGEVFDASPERMDELRKSGKLHEILVSMGWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1WEC2</accession>
    <name>K1WEC2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000354">
        <property type="protein sequence ID" value="EKC99968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WEC2"/>
    <dbReference type="HOGENOM" id="CLU_937461_0_0_1"/>
    <dbReference type="InParanoid" id="K1WEC2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="297" mass="33310" checksum="A10FE66974DECAE9" modified="2012-11-28" version="1">MPYIEYEPSFPRSQWPQASYFAPGMRDANWYTTIRFVAQRASRVVAKALREGHVASIDEADFSAAVLDIVLELADILRNNAEEDDRSVARSVDKWHMWIRKVVREVVKDARALFAANSIEALRRLDAWDAERREQMVLGCMDRVWIKLDTDEWFKTSDRCAYQVDEVHMLVERYGPDEGDKKRYWPGFVVDLDDLSTRTVLVDFKGQLHDPEPIPPRESALTSSAQALCASTGGSESPSSCSPRSAKSATGRSYSDSSVAVVTDPDARDADHEDHLSVEPAKADPSRAAAAPDECQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>K1WFZ6</accession>
    <name>K1WFZ6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">ATP-citrate synthase</fullName>
            <ecNumber evidence="23">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">A1Q2_05139</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 23">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 23">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="23"/>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WFZ6"/>
    <dbReference type="FunCoup" id="K1WFZ6">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WFZ6"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_0_1_1"/>
    <dbReference type="InParanoid" id="K1WFZ6"/>
    <dbReference type="OMA" id="MDYAWAK"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="27" id="KW-0456">Lyase</keyword>
    <keyword evidence="14 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="541"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="24">
        <location>
            <position position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR036511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR036511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EKD00474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1155" mass="125474" checksum="02DD44BB754009CC" modified="2012-11-28" version="1">MSTKAIREFDAKQLVSYWLERSPTPIPTITKSTAVPVRVAQVEYDDETGSVQPPIKPGGGLPDWVFTEKLVGKPDQLIKRRGKAGLLSLNKGADETAAWIEERAGKPVKVESTTGTLKTFIMEPFLPHPSNTEYYVCINSVRDGDWIYFTHEGGVDVGDVDAKALKLFLPVLGQFPSREVLIETLLPNVPENKKDVLADFIIRLYAVYVDLHFAYLEINPLICLDPVDGKPAEIHYLDMAAKLDQTADFICGPKWAIARDTSSGKTAAGGPVKADRGPPMVWPAPFGRDLTPEEAYIQKLDASTGASLKLTVLNQNGSVWTMVAGGGASVVYSDAIAAAGFAHELANYGEYSGAPTEGQTYEYAKTILDLMTRGEPLPNGKVLIIGGGAANFSDVAATFKGIIRALKQHKEGLIRHNVRIWVRRAGPNYQEGLKAMRLCGESLGVPIKVYGPEAAITAIVPMALGLNKPEGDLARTASQQSIAAAVEAVTANGKKNAVTEKGPDRVPVGTIKPDGGREQPGDQIVHFDTVERTSSRPWYRPFDENTRSLVFGLQPRAIQGMLDFDFSCGRKTPSVAAMIYPFGGHHIQKFYWGTKETLLPVYTTVAEAVKKHPDVDVVVNFASSRSVYQSTQEILEIPQIKAIGIIAEGVPERHAREILHMAQNKGVIIIGPATVGGIKPGCFRIGNTGGMMDNLLSCKLYRPGSVGYVSKSGGMSNELNNILSQTTNGVYEGIAIGGDRYPGTSFIDHILRYEADPDCKLILLLGEVGGTEEYRVIEAVKEGKITKPIVAWAIGTCAKMFTSEVQFGHAGSMANSDAETADAKNRAMRAAGFIVPDTFEDLPEVLKTVYDKLVENGTIKPKAEVEPPNIPMDYQWASKLGLIRKPAAFISTISDERGQELMYAGMRISDVFKEEIGIGGVISLLWFKRRLPAYACKFIEMVLQLTADHGPAVSGAMNTIITARAGKDLISSLVAGLLTIGERFGGALDGAAQEFSRGVSSGLTPREFVDQMRKANKLIPGIGHKIKSKTNPDLRVVLVVDYVRKHFPSHRTLDFALGVEDVTTQKSNTLILNVDGAIAASFCDLLYSSGAFTDEEAGEYLRNGVLNGLFVLGRSMGFIGHYLDQKQLKQPLYRAPADDIFISLQEPTRTVIQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1WH14</accession>
    <name>K1WH14_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WH14"/>
    <dbReference type="HOGENOM" id="CLU_2814242_0_0_1"/>
    <dbReference type="InParanoid" id="K1WH14"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="67" mass="7494" checksum="FEE83ACD384E25FA" modified="2012-11-28" version="1">MPSPLNRVRAQHGLRPLPGPPRPVTSVDECNTILLALTQRQEEMIRRFHTREDGENLSPPTTPPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WIU2</accession>
    <name>K1WIU2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_04365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000320">
        <property type="protein sequence ID" value="EKD01339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WIU2"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260934_0_0_1"/>
    <dbReference type="InParanoid" id="K1WIU2"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="748"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="952"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="954"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1124"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1212"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1232"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD01339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1308" mass="147116" checksum="9C3403250E43681E" modified="2012-11-28" version="1">MARDDGDGGRRNSSSSSSSRQELNATASIPQFGNDSGSLSNESASLKEKKKHKGPVGRFFLVLSNWISWFFKGWAKYSPLLAAVAAPMSTLLDIPALAACVALSSASLALNIVAMVLLLLRFSSFHGIWQRAANLSIVFWILKAIVALCNLFIFGAGEPRPPDSDFSEGFWCAVFSVLISGSIAFALFLHWLLGKIHPFDSGDDQEFRLTGRKFLLSVTGFTVLVGLEALAFSQLENWRYLDAIYFSIQTALTVGYGDITVQTAWGKVLLFIFAVLTLAQLGNAVSITIDWVQSRAVERRQKWLKKYSVAVHTSAVRRKPYATLIDEIALLHQINLHQESNALYSVMVMSFTIGYGDFTPATAAGRVFWVCYALMAVPVVTNFAVQTVTGILYTLTQHQFTNDMLSLERERDPETFAPHSHFVLRHHRRWEKVRRLYIDSLKEAGYMDDEDSMDDELDKEESPDGTPHDEKKSLKEQSDKDQTGYDRRRSKHENSQSNSDTLDENHHEKHEDDQYENADGIPAEIRPDEEDKMVNSVLDKNTHKSAKEELLDRCFKSLVDGKHGHKNAKCDDPHHGEKGGYDESEWLNEPLRREQIEFYLLKQLIGRVTRLEAQARQMLIDSMDKDLAQTLLVADRNLQIRDAFQLYGEGDEGDDALKESEDAEQNRRNHTTEAQQEHIRQLEQDTNLISGDSYDDDMLTRVRRYRSTFAEILVLSSTLLGLEGDDLKRFERWHIQLEGGSYKKWHHQRFKNLTKPPHSRRKKLEQRLRRRNMDTEGKVRPPGYKAPKERDEDDYTKSGKKKKHHHHHHKRKRATSSASAGQSDTPHVDQAQAEGRLSESDANAGRLPEETNHTHSRRSSHSSSHHDQHDSSSDQHGSSSHHRRHKKDKDSKDKDGKKKEPKKFKTKIWDAMEDELFRRTDKNVEDIIKAIPDEEEQEYLDKEKFARDLLLTSAERKKDSKQRESELKELKKEARRGELSGTKRGKRAAHEAEEGAEDEMLDDAGPSQQFDDAGAAERGEAGPGQKRKKGKKGDKPERDKDRGPDGYESPALSSDGDRDAAYGPNVWDTESDDEGPPDSDEHTDTDLGDEDTDLNSPMPSDPSDGPLDGPLGVPKGTFGFDDTPAERELATHDPSSRKTKDGLRGGPPIMQPRRQYNPGPYQAMPPARSGPVVHPAQQSKGPTKKPKSPKKSTKSSPRKSTQSRQPPPPQLQQPIQSSQASTNSSRSGTMTPRERELRKHAGHARLDDVLNTMNAGPDHLHPYATPGSAKYSGNGPILQDDEDRGNGKGLRRGDYCAPASQKIVGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WKX0</accession>
    <name>K1WKX0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000307">
        <property type="protein sequence ID" value="EKD01914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WKX0"/>
    <dbReference type="eggNOG" id="ENOG502TINM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_624363_0_0_1"/>
    <dbReference type="InParanoid" id="K1WKX0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="439" mass="48075" checksum="5025B25338CE99A6" modified="2012-11-28" version="1">MDDVDLVHTPGHHPLLPIPKELNVRPPRANAHAAEILKQMMADAPVAEDQVLDLSAGIEKSPEDATVLLPPSTLGSPAKQSVSLPSTPDETPVSQDETEIIKAVLPSAEEDNLSNGCDLPIPKPGKSYVPKVDLSSGLSSLSPQHPTRVWNSLLHACRPEHQPTVKWQYINRQKMTVTLPPEHPIVKTLARKQLPLDNNSAEYKDALRRLGGEKRWKGQTRRLKVSRIAVSSLTSQAEAQNDAVRQCIADNGLLWVNYEVMSTVDPGTYLGEQAARLRGGRPLLTVPVQPSQHASKRPMGDGDTGARSVKPKLSITTASTLKVAEDAASSGNGHAGDLERLQPTSTETGQVDWQQQLSCERGRIKALLTPAFCLEAGMPVPKYYQRIERQQGASTMFFGQVTVEHDHFESDKGFVKLREARQEVARLVFCEHFGQEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1WLB5</accession>
    <name>K1WLB5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WLB5"/>
    <dbReference type="STRING" id="1220162.K1WLB5"/>
    <dbReference type="eggNOG" id="ENOG502SDZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736053_0_0_1"/>
    <dbReference type="InParanoid" id="K1WLB5"/>
    <dbReference type="OrthoDB" id="3364747at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="376" mass="39379" checksum="DDB774868427FADC" modified="2012-11-28" version="1">MGLFSTDPDKKEEKILQREAKHDEKQVHQALKDLSIAQKEESRVAKKEHSATTELEKALQAQEKARIVLTKAEADLKAAGIRVEKARKEADDMAAAHQRAIGETQGAKDKLDQVQATFSEKKEERNERLAALGSRNISPTSSNNSSTVGVNRSASQRYASGSSLGPGGAAIGRSTSASSGGSGHRVAAPVYTGETVTSPIQASPTSPIAGGTAAGVAAGPGGVAGGEVRRVAAPEYGAPSPVSTGSGSMGLAERAAHDNAAAAQGYPTQQQPVQHVQPILQQQQHVQYADQQPVQHVQHAQPQPILQNQPIQHQQVPQIQEPVAPAAQMQARPVPPVPDVEPRTVKTHPPIIGGSPEGVQSHPPIIGGAQQQPGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM40</accession>
    <name>K1WM40_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM40"/>
    <dbReference type="STRING" id="1220162.K1WM40"/>
    <dbReference type="eggNOG" id="ENOG502S57E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050729_1_1_1"/>
    <dbReference type="InParanoid" id="K1WM40"/>
    <dbReference type="OMA" id="DERHAQM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003854846" description="Conidiation-specific protein 13" evidence="1">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32935" checksum="FFEC9D7A51221558" modified="2012-11-28" version="1">MLALWSLLSILAVTGVSAATPDEDLKNRPIINSYPNGKIDNDLFSTLQNHAKAPWQWVWPDSSQNVRDSIPRACYDHARRENLDPKDVSVYDLNHDDCGLTHRLCRHKDAKMSVEKVAEHVGRLPAKLRALVQNIFIAPGAESAYYSGNLILYRGDLNLGSLYHEFGHALDDHCPFPDKKKLAHDTQAWIDAFYKDDHVTDQYAKSNQGENFAQITVHSLYDLNVPGGISNLGTQTDGRNNWDLYDDERHAQMQYCKEYLTANNGANCGNVKDDWDFVNKNTGEKVENPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1WM61</accession>
    <name>K1WM61_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Diphenol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03571</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000296">
        <property type="protein sequence ID" value="EKD02209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WM61"/>
    <dbReference type="STRING" id="1220162.K1WM61"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349906_0_0_1"/>
    <dbReference type="InParanoid" id="K1WM61"/>
    <dbReference type="OMA" id="QIRNTNV"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13883">
        <property type="entry name" value="CuRO_2_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="267"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="393"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="664"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="805" mass="84428" checksum="CAD61F318D3B046E" modified="2012-11-28" version="1">MVTAAPNRLDKRQDNNSQAQSASSSLAVGSVANGPASSAAVSADSTGAVPSSSSAAASPPGASSGSATALGGSGDPLPSASLQSSAVQGAPAPSASSQAASADGDVAPPSSSVVASGAAPSPTSAPAVGGTNNGTGLSGLAAVGGQLQPGAVFTTTRLIDADPFPLTQTLVQTFTVPTDAAGAQATVAASGGLGDLSGLLGLGGANNAGFNKAVISASGSAVEIITAIPQPPLPSKSNSADQSVFTPAADWDITAPPQTREYTWDIEYTAGAPDGFHRRMSTVNGIYPGPLIEANKGDTIVVHVNNKLDRSQSIHWHGLRQLKTPFMDGVPGTTQCPIRAGESFTYRFNVDDETGTYWWHSHSGNTQADGLHGGLIVHSPDQPYQRGRDYDEERIVYITDWMRDQADDIVLGIITEQGFRGRPVVPPPDAALVNGVGQSVCADADPTVQCDQTQPATLQVSQNRTRLRLISTASHAMYRISIDQHNLTVIEVDDTPIEPFTATEIPMHPGQRYSVIIDGSSNAPGDQIFLRSRLATNCLGSDAQQQEQKLVLQFPGSNLNEPVDQPWPNLAGADTPCRDLGVAEGAKLLPRNITQVPQSSFKTASFWTEAGTFTNWLGFEVVGFNVSGVPYLNYANKPALGEVALNRELNTSAAGIVEFNGDLDGAVDLFINSRDAAPLAHPFHIHSRPFFILDRGEGIMDVNQLDTSRFDLVNPLRRDVITLTGQEWVVLRLPADTPGVWPMHCHIGWHLAAGKQGLINMQPNALRARIAAGEYGPSAVGEAFTAEWNGLCAGVDREVIEAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WMQ4</accession>
    <name>K1WMQ4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clp1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WMQ4"/>
    <dbReference type="STRING" id="1220162.K1WMQ4"/>
    <dbReference type="HOGENOM" id="CLU_2074789_0_0_1"/>
    <dbReference type="InParanoid" id="K1WMQ4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="118" mass="13034" checksum="FC1C329EB79102C4" modified="2012-11-28" version="1">MEGQQEQAIVPMEPGSEWRFELEPDENIALRVHSTDPVYINGEELPPTTWYPLYRYNKGAVYSPTEGKIEGEPSCLREADFSVHAAGISVHLDVDDTAAPEQPASGARAATHSVPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WNB7</accession>
    <name>K1WNB7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">A1Q2_03111</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000279">
        <property type="protein sequence ID" value="EKD02589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WNB7"/>
    <dbReference type="STRING" id="1220162.K1WNB7"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009442_0_0_1"/>
    <dbReference type="InParanoid" id="K1WNB7"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="517"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="727"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="807"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EKD02589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120009" checksum="957C9715E488F538" modified="2012-11-28" version="1">MAAEVSSVDPSAVLASITEAAQTSLNSKQQSSMLKSISKSISSSLKSASKAAADTAHTTVTDHVLNTVNVTNIVNASPTMSSQSLPPTPATITVTQTPSSVVSSLVNTAAVGVASIAAASVNNSSTVSSITSPTPLPTVGSSTQSAPNATDTWTLAPHDFVFGYIHAHEAHGKTSANVSHPKYRYAHLWWIIIGGLTCVYAICHHLNFSGGSIGSWWNKWGIRRHTFRIGRLYSHVLPSNNMLVIMFIVAFTTLCLALLGPDHLASDIPVWNFVKRDSPDALQTLVTWTVEKDWWTVGNRFGMMVFCCLPFLIILALKAPPFAILSLPFFTHVHWDKIGTFHRAGGWFVYFMVTIHVYTWTVQLFKNTYHGVPMWKAMLTTDRFRFGITAYCMWTLAMVTSIKWVRNRYYGLFYWVHVVCMIGGIICAMCHHSIIWYYAGIALIFWAGDKFCRFIRYMYINGFPSRAAPVPHKADLDGTIAHLDYVEKALSFYSSESSSDVSALPPPGTNLLIVPRPPPIPAGYAQAQLLPSRTVRLTIRTARPMVHGPGQSVLLTLPDITRWRSHPFTVSSNDPYEIVLIIKARNGTTRKLYDYVREQYEKTMVPDRNSRRMSIIPEAKPVHIRARIEGPMGSAGRVAWTDYTNVLMVCGGSGVTFGLAMIDYLSSVMSERGFLGKTKRLRFVWIVREYAEITWAASALRRFSNRLDESQLQIDIYVTGGATSAPIKNRTPLSSRPGSSGHGDETTVEELSPPSADRYVVRNDSADSLYSQYEGTGTRAPQRGYYDGEDPETGLAYDQVIGLTNFEGEEDQDDPNADELSRKLAAEGRVRRARSRKMKQMQRNMQLQPPGSEKPPLSPLREKAPLSPALPKSPHSPRDNSLDRQRSPRNGPFIPPRSEARRSGTEQDSKLAEILTTDSPQPAEHMRSESVSSCGTAYDRYEPFRKTSIESVAPSIYDVEMARSNAVSLCSRTGSMVQLEDTKDGQKHRCSGCGRHGAEKLWIDEGDYAAAHILSENAHIGRPKLASIVQEELERAEGATIIGNCGPVLLNTSLRNIVSKSIDAVAIARGDRRGHVTIYSEDFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPN2</accession>
    <name>K1WPN2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000270">
        <property type="protein sequence ID" value="EKD03019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPN2"/>
    <dbReference type="HOGENOM" id="CLU_861033_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPN2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD03019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="323" mass="37256" checksum="8244C4752943FAA7" modified="2012-11-28" version="1">MVASISYVGFPHIFEEVAAQCDFSTQCKLRLLCSATKEYIDRTHCWLFTAYIELPRPDDDTGPITVPQQTTVWLGYGDDYPTMPAMYIPERSDAWRERNEQECQHSLKIISRYPAHQVLLDFELLLWDTTFQRCADYAHYARPLQLLETASRVRLFHCHTGYTDSLKRLRQPAESTCPMIPPRVKTLIMSLDEDLCLCQSRISHSAETLYLSLFRNLIECEWGDDVSSVCSLSLDLFKPCVQHLYFEACYTLDVSNYLKAISSKPRHPNLTVTVVPSYTSSDQKSRKKTDRKFQKAAKEWPAVLGVPVTLGKYEEVWPALWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPQ0</accession>
    <name>K1WPQ0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPQ0"/>
    <dbReference type="eggNOG" id="ENOG502QV5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973818_0_0_1"/>
    <dbReference type="InParanoid" id="K1WPQ0"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="286" mass="30647" checksum="0E3B38A66D77676B" modified="2012-11-28" version="1">MPAAVADWHALLKPDPSSCPNLSPAGHRAVRRVAPPLRPGLPAVAPVQSDMGVVRRSACRGYMTSAVVREMPSPSPAFGMAELANSSLVLYIAYFPRKPALARENTTEEVYAAKVADLRAERRKGYAVAWVCLAHFAVLTIVTVILLLYSPIHPRTPALRRLATFCGLSATLLAILQYAPQIYKTYRSGLVGALSIGTMLIQVPGSILFVVSIMLGDGTDWTSWIPYAVTGAMQGVLLGICVAWTLRQRRLGIDAFGNPIEGRAVVVDERTPLISNGNGNGNGATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1WPQ7</accession>
    <name>K1WPQ7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000269">
        <property type="protein sequence ID" value="EKD03044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WPQ7"/>
    <dbReference type="FunCoup" id="K1WPQ7">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WPQ7"/>
    <dbReference type="eggNOG" id="KOG2370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011759_2_0_1"/>
    <dbReference type="InParanoid" id="K1WPQ7"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="257"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="628"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD03044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="752" mass="88555" checksum="B061203D53159E3D" modified="2012-11-28" version="1">MSRPSSPERDSREKVRYDDVDVPAGPSGSSKRDDKRSDERYDSDRERRRRDRDRDDRRRDRDRGRDYDRDRDRRRSDRKRDDERRERRRDRSRSSSREKERTRDRDRDRRRDRDRDRDRSTSRDRERRRDRERDRDRRRDSRSPSTIERRKRKEAKRAAKAASRREADAEHARKLTELTMYSSNSNPFQDPNLTEKFTWHKKIEKDKKAGLTAEDIARREEQRKLEAKQELEKLNKKRADRETEMKLREEEETRKRRLAEDAQMMEWINKEDDFQLEQSRRRAGIRLRERRAKAIDFLAINLRFADAKCLGKQTAAIGALAGASAREDEEDGWGWADAGLEFEMDEPWLIFELEQDIKMYLSLEKNPVNIQFWEAMQVVCQHHLALLRDPDRAVGGAQYNAEVDASASQIVTGLSISKLDALEQRTRDLLSGGGAVDSEFWALVLDKIAIARAQNRLAGIHEIVLRNRLELFKKRQREDAARAQADLADGEEGEDVEEAYEADEEDYVEPYERDMSPVPMDLDAVVRDADLCHLPIVDEADMLRSLYEARHTISNKAYMPKVARAEPVGQVAEDTGPPAGHYDIDAETEAHWKAAIRAEPKDWGDSESEHDMEEGDLASGLQEAEYDWSDRFRPRKPRYFNRVHTGYEWTQYNQSHYDFDNPPPKIVQGYKFNIFYPDLIDKSVTPTYVVQKIPGDNDTQIIIFKAGPPYEDIAFRIVKRPWEYSHRKGFVSTFGSGVLRLYFSFSRQFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1WR61</accession>
    <name>K1WR61_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_02107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000246">
        <property type="protein sequence ID" value="EKD03524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WR61"/>
    <dbReference type="STRING" id="1220162.K1WR61"/>
    <dbReference type="HOGENOM" id="CLU_326295_0_0_1"/>
    <dbReference type="InParanoid" id="K1WR61"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF63">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="553"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="869"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="883" mass="95858" checksum="858CC005B8B0A741" modified="2012-11-28" version="1">MASQSQVSAPSTTTSPPSAPSSTPGITRESFLQRARAAALRDKGGSKSPASSRAQSPAGSRSSTAQQVTQPEDAVSQNGQAARAFPALESAPRLDTITQSAPSWSVDRALDSVERTQPAPASSPTTEVLEMDELQDSKADQRHSSPDSVEFIQETAPTQQRRRPPLVSSSAPAPSSSTVQPAAGPAPPTLDNLAEDSPSAAVEDQLELSVPDVPVTNVAEPEVPENTTTAEAIASLPTAGSSDPSQPALVGDPSPLLPLIQSFPPDSRRVAIRSFEALPEDIKRKVLGSKAMMDNFKAYVLTNVVPAQQQTTAASTTTTSQPSAVNAQPIPNESADLAQQQSQAQQVQRAQLAQQQAWPAVPAADITNIGEQPSTNSGNTVPTLQQTQSPQLHDPHSSAYVAQQQQSPVVPQVVQQVQSPTTAFQESPGVSIASTLQSQSPVIVQAAPQHYGPAVPPSVVPSVQAPLHRVGQGTTTAPATVPNSAVSSALVSVGGMENRLGAWTQGLFQDVRQNLVAPLEAALREAERQRDQWKSVAENNSAALSQLLGQQANQQWQARLTAVSNQLIKAREERDRFKELYQTSIVNFNSRTSQLQSAQTAYQDLERRFNENRKHTLTIMNGFETLKRQNDELNRQKQVWMQSSNAAAQQQQIQQLQQENNALMSESSNKDAKVAELEKRVKELQHDRETAIKVMKTEAEKWRETAEKNAALEELARQADSRSAALEIKLRGVEMHAQAKIAELEGRLKADRPPAPADNGAEARVAELERRLQQAERMAQADKEHAESKAQAERRAQLRAIELEKQLKESESEVQDYKQQFESLRTTAQAKIDQQHATITKLRERNQRYKEVARQSIGGASPALKRPADSQASPSQQSQRFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1WRJ5</accession>
    <name>K1WRJ5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_02066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000244">
        <property type="protein sequence ID" value="EKD03629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WRJ5"/>
    <dbReference type="HOGENOM" id="CLU_542039_0_0_1"/>
    <dbReference type="InParanoid" id="K1WRJ5"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="503" mass="54870" checksum="7D9F115D01A4B9BC" modified="2012-11-28" version="1">MYPDTAPPPTLMANGAPVELESPTESNVPKNGEDAEPRVTIPALSYPHIIDAIFASAPYASLLRLRAVDKAWQERADALLGTHLVFSTGGGRSSTDPMRVEVSSLATNRGKRARRLRFRVERTTTPTVRAEAQRWLEKEAMPRVLDLDNWGRNSGNSRWWLPAPLREAMEALRPDTVRIYGPAQAAMGRWVARTERTVVFTAIPPWNTHTAVKIVPAPMLPDTKRLVVNLTIHERGRHVPLGELATWDTLPDDLEEIVLIVKDAETAKTFVPRTNTGFVPRPTAASLARQKAQQTRRAKEGRGGEGDRATRQEWGVLRPLHSWLVSAWRCGGVKALMRENHCIKFTIVGMTEIKANHAGFTNAMTQEEKAAKLVESRDAIADIWKSNFEPTPVPAAPGSRSVSRSAASRAGDSNSCQNALGASTASLAPSAASNSGASSLSTAVSELSLAPSAASTATAPSPAPAEEEFWTTAEVDKVVSGIRFLTREEYKAECPNWAIEWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSG5</accession>
    <name>K1WSG5_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_01753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSG5"/>
    <dbReference type="STRING" id="1220162.K1WSG5"/>
    <dbReference type="HOGENOM" id="CLU_652447_0_0_1"/>
    <dbReference type="InParanoid" id="K1WSG5"/>
    <dbReference type="OMA" id="PSESHEM"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD03929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="421" mass="43463" checksum="84BB1032E3819E0B" modified="2012-11-28" version="1">MVRLDHKSYLSPPGSQPSSQPPSQPSSSSSHSDHAHYSIVEDYSGSERTRPDQFVPPRQPPALSSFEGPKQFVSPASTVISAPPPRSSSYSRLDQLPGQQSLSQAGMQAMGSAGSPGRQPIKNPPLHINTARAQRSMSPTYQNQRRSTSPLGPGVPLPGSTSSSSLHAFSSATPVPSYPPMSPSGPVHAAHMISPGPSSIATPVRAVAPPSRVNPMVGASPPAIPPAAPAQPPSFGQVADDAGPATPAGPASSTGHASSGPASPAVGLAVSGPAIPAMLAQAPARSTSLDPRAGPATPISPMIQTPSGAMQFPFSALSPNPSPKQTFSPLPSESHEMEEYFDALSVDQIIRDAPQVQNVEPQYAPDVQGLTASVHGYISPLPSPSPERPERLPYLSGLSASSERLPYLSPEGGSPTRHSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1WSH1</accession>
    <name>K1WSH1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1WSH1"/>
    <dbReference type="FunCoup" id="K1WSH1">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1WSH1"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="eggNOG" id="KOG1349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044656_1_0_1"/>
    <dbReference type="InParanoid" id="K1WSH1"/>
    <dbReference type="OMA" id="CSHDIAN"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="279" mass="30956" checksum="10B7B01DA59BC382" modified="2012-11-28" version="1">MYRTIKRLGIPDSNIILMLADDVACDARNIFPASVFGNRDRQLDLYGDSVEVDYRGYEVTVENFLRVLTGRFDKHVPPNKRLLTDASSNVFLYLTGHGGDEFLKFQDNEELSAFDIADAVEQMHEKRRYNKLLFMIDTCQANTMFSQFYSPDIIATGSSAKGENSLSHHADDQIGVSVIDSYTHFTLNYLEGFNKSSKATFDSYDPVQILSNAGVSTSLSKTPPAEILLTDFLGGVSRVEISDGKVSVGEDGWIESETVEVETLPPPLNAFRPISAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V0N4</accession>
    <name>K1V0N4_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrC family homology region profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000410">
        <property type="protein sequence ID" value="EKC97489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V0N4"/>
    <dbReference type="FunCoup" id="K1V0N4">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V0N4"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_3_1_1"/>
    <dbReference type="InParanoid" id="K1V0N4"/>
    <dbReference type="OMA" id="WRATFDT"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF95">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrC family homology region profile" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="288" mass="32401" checksum="83792A58086BF72A" modified="2012-11-28" version="1">MAVHNVAVAGFGEGTNELYDRALPSYPAAALQFIKKELPDSPLTIVEAGSGTGIFSRLLLSPPNPEYPRFDVKTLAAVEPSSGMRAAFEKGLAKVPKQDLEGKNVITVDGGFDDFSNSGVAKGDADAVVIAQAFHWCPDYQKALTEIAEYLKPGAPLILIWNLEQNQDEWHQALRDLYQPLDQGSPQYYRGGWKKLYDTDAYKSLFEPAQIEQFPWHMGMTEEGIRDRIFSKSYLTENNLKGQEREDFEKKLRQLIASDGPGKEYIDKDAGIIKYRYNTDLVIMRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>K1V192</accession>
    <name>K1V192_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000405">
        <property type="protein sequence ID" value="EKC97659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V192"/>
    <dbReference type="STRING" id="1220162.K1V192"/>
    <dbReference type="eggNOG" id="ENOG502SKCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545353_0_0_1"/>
    <dbReference type="InParanoid" id="K1V192"/>
    <dbReference type="OrthoDB" id="2570580at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="500" mass="53657" checksum="DE62E7B5FACA0491" modified="2012-11-28" version="1">MGGVHYHAFIPPRSLLPLNDPRTFQPTEHSLHVISLPDQVDQVDAEPARSAEPREPAHAHARNHDEVTTTAPRIARRRGDNSGAEAAGVAITDEAQVSMHADNSKTVVTKPVDDESWQESSDSVPLRRSRRLRSSVHASDCRPRFCRNANSAPRFLAPPGSLLGGAWRNMSLGTAYSLMARGMSFTSFQLRAVTDMQSPLIVAGLGDVTAAISSCIGLAIVGLKPASLDAAAPIEADPTMRSARPARKDVSQKCSAQTCVSDLLRHNRQPSHSAAAAIPVQGSRADRRALDCVLEGACAGCWGGGPGQLHRHTVRVVRARLGRRRAPRRCRAPPSKNTRAAGSASTKFLGQQEAAKGQWTSFGTLGLPTCVPRITSVLACDPTSAKDPANALLADAEFQPATPNSDPPREAQLVLSPKNGASPPQPTVLFRTLPRRDAVADDYVYRPGARGAQRQEEMRPEDRALRPDFGTLARSDIGVRRVAEMAQWCAEWVGGEGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>K1V1F8</accession>
    <name>K1V1F8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_07953</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000403">
        <property type="protein sequence ID" value="EKC97754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V1F8"/>
    <dbReference type="FunCoup" id="K1V1F8">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V1F8"/>
    <dbReference type="eggNOG" id="KOG1247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_3_2_1"/>
    <dbReference type="InParanoid" id="K1V1F8"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000037">
        <property type="entry name" value="Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="87"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="383"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="490"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="638"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKC97754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="738" mass="82004" checksum="D1F436A25CD0AF5A" modified="2012-11-28" version="1">MAGVQANRVRRSGREGNWSSAFVIAARIPLLSPPPSSSTTLPRITELPPALGTETLAMADRKIRQDDSILMHIHNPADGPVLPKEDVNNVPHLGNIIGSTLSADVFARYNRIQNIPTLFVCGTDEYGTATETKALEEGVTPMELCTKFNKLHTEVYKWFQIGFDQWGRTSDPAQTEVTQDIYKHIHDNGYFELETSEQTYCEDDKLFLADRFVEGECPNCGYDDARGDQCDKCALTFSSPTELKNPRCKRNKNHKVSVRPSTHACIRLNAIQPKLEKWLQEQRVKGKWASNVVITDKGEIVEPRMLGEGLRPSAVTRDLNWGVAVPKVGDPEADEKLANKVIYVWFDAPIGYISMTKSYTDEWQKWWMNPDNVELFQFMGKDTEYLNYEDTKFSKSRNIGVFGTQAAEIGQPPSVWRYYLISNRPETSDSAFQWSKFISAVNSELLANLGNFVNRVIKFVNAKFDSVVPGPSDTKGGEVPETPRDSSEGAKIDAEFYKDINAKLQEYKEAMDATKLRNGLFLAMSLSARGNQYLQDSGLDNALLAENPERCGEVCLNAINLIYALTAVFHPFMPETSEDILKQLNAPARTLPLKFSIDILPGHKLGKAAHLFQRIDNTDGKAELKWKRQFGGVDAAAADGADAATDKQAKTPKAEDHKGNWAKANEAKKKKAEAAAAAAAAKSPEERELESKLEAQNLLVKNIRTGKAEGDAAKEGAAAKALKAQLQELRKKLKEAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1V243</accession>
    <name>K1V243_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_07796</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000400">
        <property type="protein sequence ID" value="EKC97999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V243"/>
    <dbReference type="STRING" id="1220162.K1V243"/>
    <dbReference type="eggNOG" id="ENOG502S359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314538_0_0_1"/>
    <dbReference type="InParanoid" id="K1V243"/>
    <dbReference type="OMA" id="MYQNQFP"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="56"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="751"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
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            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="479"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="594"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKC97999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="929" mass="97563" checksum="42879D9C7A6A42C3" modified="2012-11-28" version="1">MASLGDLSKKYSSQLKQLQGIFPSWDEEDLLFTLQDSKGNIEEAVLAISEGRASQFTEATKKKPAKSAQSHKSHRHDGGSGWENVDFASGARGGRGGGRGGRGGVPRGMAAVRGARVGRAGARGGARGGFTGVNGGAKKTDGGPSDAWPTTTETTVEGWNNQVEQSEKASQHEDDEDDGGWGVSDDTPAPAKPSTATGAWGAGAPKHQQQKKAAPADKPAPAPKSAPPAPAKEVKEPAPAVPAVPAKKTWAQIAKYVTSQYPIADHRPIEKPKPTPPPAPKAEPKQPEEPKPEEPKEEKEAPVEEEQKPEEEKPEEPTTDAPEPSTEQSAATTAALDAPTEDEAAKSNGPDASEKSEEPQWASDPAIVGSASAPAPAQQAAPAAAAPEPVTTYTGPPGFNPIASKAVGQQQQPRTNSRSAQRYKNADGQAVVLPAAASGVSAVEVQFGSLSFGGLNGDGVEAPVQEPSEPASQADNARPTHAASSTTPSNTSAPAPSQPSAPAAPAAQAPGASAWPQQQQQPQQQQQAQQPQHPAGFPPSHTLQQQMSAYQSYGQQQQQPQHSGHEASTPQQQPQQHSQFGGYRQQQDYYNQIGSQQGQQNQQNQQQQSQQQTPGASSDSQSQQPPAQQQQSQPQQPQQQHSYDQGHFGGFGGQQQLFGQQHGQQNEYGHRGFDSYSNTGYPRPPTDDNKAAPAPSHTSAPAQPQHQQHGGYYTSHLGNMGYYQSGPYNPYYQYGQAPTPGFQQYYPMAGRNLYGQPAPQAPPAPIPNKPTPPAAHHSPYGGPQGYPSSSGFDDQPYGLGRFGDNKAGGAPQGAGATQGQQTPQPIGASYPGQQGLHNFLGGSGSTGSAQPNRPQAGTPDDGFNKNQTGASNTSAPGGASAGARNQPNQPQQQAFASYPYGGYQNHDWSPYGQQHYSGSRNGGYSGWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3M9</accession>
    <name>K1V3M9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000387">
        <property type="protein sequence ID" value="EKC98554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3M9"/>
    <dbReference type="HOGENOM" id="CLU_880505_0_0_1"/>
    <dbReference type="InParanoid" id="K1V3M9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="316" mass="34432" checksum="ED972F04945FFF11" modified="2012-11-28" version="1">MQCPIFGLDLIKRLNCLNRLLRLKDTQARNSNSSKPNIFDYAIIRRTSPPTTSPATPSGSGTPPSSSRSTTPYQTERRTRQSAERHASDPHGTRHTPQTSAYRSVTHKYCGRSAHPAAKHSHLPEWRTSGNLFQPPKISLRDIKWNTASVPSLHRTTNASISEHQPLPQSTQLGLGLQGQQRLLRVHINSSTDIDQSTPQVQSVVLDSHPSDPSTLLTLELATLEAHANTPLAAHNHGPHHALHSRRPQHRAAGTPAADTQDARDGPEPAPRAVGRAEGDSRQELDIASPSAVARRDRKASSGRMGRMAGPTVPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1V3U3</accession>
    <name>K1V3U3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Inositol phosphorylsphingolipid-phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_07046</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000385">
        <property type="protein sequence ID" value="EKC98624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V3U3"/>
    <dbReference type="FunCoup" id="K1V3U3">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V3U3"/>
    <dbReference type="eggNOG" id="KOG3873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034001_2_0_1"/>
    <dbReference type="InParanoid" id="K1V3U3"/>
    <dbReference type="OMA" id="IEESSMF"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKC98624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="431" mass="47088" checksum="2D4BCD73D36C0834" modified="2012-11-28" version="1">MAELKILTFNVCKDRPRRLRAIAASLRDSTYDIVCLQELWVHAEFRQFRDDVEGTFAYSRFFHTGALGSGLAVFSKYPIIESQALPYHLSGLPSHPVDGDFFVNKAAARVVVNVPGFGECEVWDTHMHAAGESGPETRQAHRISQAWQLSSECRKAVRGGRYLFCMGDFNSQPFSVPIALMKNHGGLKDSFREAHPGCDDAAPAGLSAEDALTTLGMTCDSPLNSWSAGKPIPASVLANGGKRLDYIFFAEPAGKPRLRVVRSDVVMTDLIDGTTSMSDHFGLASTFALDTSTASGRSEAQEQGRQAHPLAQVPYSDDEPAHITGEGHGAEAQSIRKALGVMRDYYPEAARRSKIFVDITIACVLLEIALAVGSAWQPKSWIQPIFTVLAFAFGIAGATSLYIGWLWGRWERGLLDECVSEMENELAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1V4Z7</accession>
    <name>K1V4Z7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V4Z7"/>
    <dbReference type="HOGENOM" id="CLU_723988_0_0_1"/>
    <dbReference type="InParanoid" id="K1V4Z7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="355" mass="40537" checksum="CA6306F4F63B297A" modified="2012-11-28" version="1">MVTQLDARFYPHIIDSIFDELVSTHPRKARLVCKAWCNRIDTDFANWLAVDTCVPGIRNQPALGPFEACPEPYSWEIVAARHPTIAYQRQSLWEDPETDYREVQNVRDIQLEPAVLDILDSVEWVYCPIGLPPADTVRFQVERYRSISLGCANMLPHVRRIIFSDGAYSDDRARVTPARGEAHALAATCTKQNCGKEHTQRIVINARTPVPRVEQRMAFLPEGLPELVVIFHGWRVVRGFDHSRLMNYHAGDPLNDIREVILAATKQGTRVTVVNEAMSDLRTGEKRTNVICVHEAILHFLNVDTENDEVHSLETLSPLVEFLTLEEYKARVGEEQFKIETMTDVTIQRLVDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6S1</accession>
    <name>K1V6S1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_05999</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6S1"/>
    <dbReference type="FunCoup" id="K1V6S1">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V6S1"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027221_0_0_1"/>
    <dbReference type="InParanoid" id="K1V6S1"/>
    <dbReference type="OMA" id="WSLHRFI"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="106"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="517" mass="58572" checksum="6B76A8E0BB3DA559" modified="2012-11-28" version="1">MFPGDSTDSTPHQYHQYTMEEDGFHSISWDDAPPARAAAGFADMSAVGAADDDDDDGFDKISATSPLHEEAPEQPSTSRPPQPQTHTAARGAAPELDIDDLWGGRWMSVTVSDPVKEHEGSKDMYVSYAVKTQTNLPTFEKPSASVRRRFQDFVFLRDHLAKSFPACVIPPIPDKHRLGELLPRCSVADMAEYIKGDRFSSEFVEKRRLDLQRFVDRLAKHPILRRSKLVCDFLSSENWSVAKHKHLANPPPDSHTSLMDSLSDTLVNVFTRVRKPDPRFVEMTDNLERFEDGMSQIERLVTRNKNRGDDLAADYQDMAAAYQGLGYLESGITEPLNRFAEKMLDFSTLLKHQNQAALEPFLQQTHSLLAYSAAHRATIKLRDQKQLDFEELGAYLSAVVSERDRLAALNSGHAGGPVGLGTYLRDQVDKLRGTDDIHTRRERMRKLDGKIHELQEAVTAANDTSNSFSDEVLKEHEIFELSKQQEMKELLKRYADGQVEMLQRAMDDWDRRIRVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>K1V6T9</accession>
    <name>K1V6T9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1688-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000365">
        <property type="protein sequence ID" value="EKC99719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V6T9"/>
    <dbReference type="STRING" id="1220162.K1V6T9"/>
    <dbReference type="eggNOG" id="ENOG502QR4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026445_1_0_1"/>
    <dbReference type="InParanoid" id="K1V6T9"/>
    <dbReference type="OMA" id="VPMFTAD"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="51836" checksum="99C4FB02C609C066" modified="2012-11-28" version="1">MTLPTATDSTVAYLRSLGAVRARSKQVYDLIVAGKADHWDWDESKLQTVIDFCAGLIQTRTPFLVSESRLPRPHFRASNALFELLCLSALIVFPVGLRSSAHCRRNHFGTPTPTKRDRVGELLKDPRFPKDPEERAATLIDLYVVSVLLDAGAGNKWTYVEGDSDWVGGRSEGLAVASWHMFRDGVFSDKGKEDPFRVDADSSAAALQRLTPEILAKHMQVTEENPMSGLEGRTALLSKLGGALAARPDIVKNGRPGDLVSYFEPKLGPNKTLNLDLFWQTLFELLGPIWPARTTLPGSDAVLGDVWPCPSLDRSLGSENRKLGDSLVPFHKLTQWLCYSLIEPIQDQAGWTVRSSSGNEQTGLPEYRNGGLIVDFDLLKLRPDSLDESVWVNGKDAPPKLEPSSPAVVEWRAATVVALDRIAEGVKQKLGKDLELAQVLEAATWKGGREIAKAKRPVGAGPPIEIVSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>K1V7M2</accession>
    <name>K1V7M2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000353">
        <property type="protein sequence ID" value="EKC99999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V7M2"/>
    <dbReference type="HOGENOM" id="CLU_608570_0_0_1"/>
    <dbReference type="InParanoid" id="K1V7M2"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC99999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="450" mass="50425" checksum="AC3DC8293999DC85" modified="2012-11-28" version="1">MFVPTDMDRALGITSHPKPTLDLDDFWAFVRAQGFIPGQTADHVDCEEVWLVNANHPLVVDALSKIDGVTRAKYDELHALEAAAEGSTGAKADEYRHQRQALHAVIERRLAYCRAYLYTDGAFCIAKGESDSFCANPGQCHFNSQARVIVAKPKAPLQSSFLAARNSTKCKPVRVSSDDIRLLADCVDCSVADQTCPLRNRVRLGHLAGPAASVSLLQNTMDTLRDSVKCVQEAIHEGGLDIRPDLDLIETSVEMIDLVLANPIKLGKRVSHDRLLELDLVSISETKHRTGKLNDLIHSYRQSYKHRARDVRKFKAITTTKPKIRAQHLNHLTSQALESDPVVDPALFTSMEGLATHLQQTRTEIALARRAGRPYPEPKRDLVRTILRIAPFARDIFFTRMLRDWVQEVSNDMTRRSRRVAKDRQAKIDEAIAKLKELVGDLEGDMKQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8I7</accession>
    <name>K1V8I7_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NCA2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_05462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8I7"/>
    <dbReference type="FunCoup" id="K1V8I7">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8I7"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008227_3_0_1"/>
    <dbReference type="InParanoid" id="K1V8I7"/>
    <dbReference type="OMA" id="YHEFHED"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD00285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="69869" checksum="93D1312ADE084E94" modified="2012-11-28" version="1">MGKSPTSSFSEEQLKHNLGALSSIPLTVSDPSKLSAESTSPTPSKKLKDALDELSASDPPSMGKLAHLLKDIANPSGNISGIANVSPVDAAAEAEILARAVTIIWSNVTDDLIDSALELDDDLTYWEIGLQSRWGAVIYLVQSLPNRIFHAVGSTLTPGSIWNQVKSIHWPKRGSLFRPLHGYGSDKISDQLAAITSPVRLTRNEMIGNVRALQFSRDAAARRVGILASQAPNWAGRETNGMLSTESMEDETTRVYKLLCVVLETGPPDEKTVHEVSVGKRKPKKQVKLAETKTVELPAPEATAQSLLDLMTVGLPEARNNLRDTLKNYGRPSFATRYWPAFLLLPPCLYYAGRLFGNNKEWLKEQLVNAKETVRGFLVQWVWEPIEHITKTMRGGGEGLGVAPETVKTDRESLDRMVMDLGKDYYHMNDQQLEKLKDQVNAGDLESVLKVYESEMRAPIKNAIFGYLIRTLLIQVQKTKTDLSVALLQLDSLLQSQQLTFAFVGIAPSILVLWMVWGWIRNLTSGAKRGKGRKRRYFYGMRSIERLLITSTKEDGRMNDRDRGMLIVDVSGLRVWAAGIKRSKREAFLSDIRLFEDQNLDRDDKLRVVDRIWRCWGIDGTHSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8Q4</accession>
    <name>K1V8Q4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8Q4"/>
    <dbReference type="FunCoup" id="K1V8Q4">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8Q4"/>
    <dbReference type="eggNOG" id="KOG2545">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029811_2_1_1"/>
    <dbReference type="InParanoid" id="K1V8Q4"/>
    <dbReference type="OMA" id="FFRTNIS"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="487" mass="52376" checksum="BFE0D1D4A0911D7D" modified="2012-11-28" version="1">MLPVEDIIRIAVRETDAPAVGEDYAARVQAALEHPESIPEYSKDSKALDVVRFRALLQDTGFPAEVYQDSNGGLAERWIGWGVETGPGLQTLGTPDKHPLSALGHKAPAALLKVYDAEVSYRPASVLDVIGIVSQGMLPSFDDGDAPLVPAVHVLNATVLDAPHAATPTDAAARQSLVEHLSRAFDPPDATAGELLLLSLLARPDVRQGVALGQLNLNVIRPKNGSSLNAHLAPLTPALVNLPLSLDLLHRAPFRPKSDGALLSPGLLQLAPGTLLLVDEDALGEGELQERAVRNLQALSELLAEQNLTYEYPYSSGVRIPTSIRALVESEGRSLLPVDAALPATLSTTVQAPSEDDLARWRAYLAHHSSSAHAATFSMPDAVATMIQDEFVRERQQGGAGSIEKAEARLKLRMKLARLLTLSEGSEVTEPVWRRAVELENEIERRNAEREARRRENTQGRTMGQPSQMAATPNGSAEQPNGEPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8S1</accession>
    <name>K1V8S1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SEC63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_05359</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000343">
        <property type="protein sequence ID" value="EKD00390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8S1"/>
    <dbReference type="FunCoup" id="K1V8S1">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V8S1"/>
    <dbReference type="eggNOG" id="KOG0721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014210_0_0_1"/>
    <dbReference type="InParanoid" id="K1V8S1"/>
    <dbReference type="OMA" id="RAILHAH"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SEC63" evidence="10">
        <location>
            <begin position="188"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD00390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="636" mass="70187" checksum="1114C88A7AAFE1D8" modified="2012-11-28" version="1">MPGISYDESGSLASYFGVTCLGLILIPATFYTLRTEPTARSSSPFGLGPLRLPGVQPLPCAAASGAFHLRPIRDFGTVHQLNGEADQKALQEALSEIIKLGVNETMEMAEAKFVDITKAYKSLTDEATRENLQKYGNPDGPQQREDKIAIPKWVVEGNSQALVLLAYGLVLGFGIPWLVGRWWFRQRSLTRDGVLNGTAELFFHQLREDTDFLSLVTILSSALEYVPILGKKSKGGKKARKERQAKIEELEKVLDEKRKELGIEEDPTMSRDSRASVTTAVGRRARALLWAQLFRLKLDPELEEEQLEVLRATPPLIHALSNIALAHNWLNCSLMCLRLQSALAQGIPIGVSGLAQFPGISLEEAQDMAITTGAEGQRWLEKWLAADVKGLDEARKVAKTWPRLEIKDVEFRVEDEKIVPPGSIVSLNYKARFAYPVPATKANGKAIADEKPVVSKSSKSSKPITAGYLHAPRWPGNRVPRYHVLLGDSKLNKVIVQPTRNSEIPLPNPDGTPGEFKEFKLQFQAPPQANLYSFVAHFVSDSLVGADVQKPVMLRVQDPPEVSDDSDDDISEPEEDTLAGQMAMMRGEKVKPSAVHGYDDESEYETDTDTSSDEEGPAKPRSRGGRPINVDTSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1V8U1</accession>
    <name>K1V8U1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_05252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V8U1"/>
    <dbReference type="eggNOG" id="ENOG502SBX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188562_1_2_1"/>
    <dbReference type="InParanoid" id="K1V8U1"/>
    <dbReference type="OMA" id="ADYNSVH"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7217" checksum="3DDCE9D22F3F4C27" modified="2012-11-28" version="1">MAPRFQDKQPLKTLAKATKSCAKESLAYGQCIGKQYQDVRKDMCAPEFAQFKNCVQKAFGRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>K1V987</accession>
    <name>K1V987_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V987"/>
    <dbReference type="eggNOG" id="ENOG502S6V6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366087_0_0_1"/>
    <dbReference type="InParanoid" id="K1V987"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="762" mass="83973" checksum="55C1E9E34D28324F" modified="2012-11-28" version="1">MSLNRSTGPTQDLSFADQQELLAFIDKRNWFEGKLESLKALPRVYPFVHPYLVADSKSTSGYVRAGADKSEWRLPDRAQLAAWQNERNALEDEVNRFDDGDMERMKQKTRVLTRMPLTQPSTDLVEVTLELIVIIDHLHTLLRDREALLELTALRLQWDDLRFEATRESASVKFDIDHVVEVAQAWMPGAPALDSRSNLKAPVPSKASSSSQGSSLTDALLQTPAGSNAAVGVSPMRQLTPSPVRSASKSALHISILRSQLVGLQTRHRNYAFNLVKRASTVLDRMIDAAGRMKELGGIEGPMEDEANRRKGAVPEAFIEIQESLEEDAKDIGERVTWCSLFEGQSKKAHEYYVACNHSRHLAGQFLTKIELALAEPASSFTHAELNQLFKEASDILPAEIDDTFPRPTHASFPTKDQHNKDIESVLRAVRKEAQDELDIARKALTFYSSLLKARESLQAQQNRVKTLRHQLHQTLLRFEQGVADAPRPSLEDVARNGETHAGWLAAVPDWIDSGDLLVRAASDTQEATTLALMQYRKALQPPMAVKKLAPDTGVPDDLGTIVNDDASDLIDVARRCANLASSVKTDHEALPIILGVRRDNSDVSSDVEELRKKLIGAVNRAAWSSRTSVSAKYEDLDDELQTIVRQAEGAGEELSRLEAIIGNRLPVTMPLKEASTANLEGIDAARRDLGILSRVTRQAKAVASVSSEAAEHLVTLDSARDAISASNDSINDALDNIANISCALIATVSNDISFPNQHDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>K1V9F9</accession>
    <name>K1V9F9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_05113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1V9F9"/>
    <dbReference type="FunCoup" id="K1V9F9">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1V9F9"/>
    <dbReference type="eggNOG" id="KOG3985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1305653_0_0_1"/>
    <dbReference type="InParanoid" id="K1V9F9"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="211" mass="23209" checksum="DBB101A550AC2DB8" modified="2012-11-28" version="1">MAEQNDKILVGVIGGSGLYHLDNLTFVRKVEVETPWGKPSSPITISSLPDGSQVAFISRHGAAHTITPSEVPARANIAALKHLGVRAIVAFSAVGSLREEIAPGHFVIPDQIIDRTKGIRPDTYFRGEGLVVHSMFGEPFSRQLNRFIAPKVKEILDKEGVSVHTDKTVVCMEGEFRRLASMEMHDSDFGERKAVNKAKAIKRARRDRATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VA40</accession>
    <name>K1VA40_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_04838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000332">
        <property type="protein sequence ID" value="EKD00870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VA40"/>
    <dbReference type="HOGENOM" id="CLU_1644912_0_0_1"/>
    <dbReference type="InParanoid" id="K1VA40"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD00870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="161" mass="17550" checksum="F9249531AA1D0490" modified="2012-11-28" version="1">MPSSLPGSPKDRSRFDVDVIEEIICVSCCSTTNRRATRRIVVNPDQPSLADAAVLFVVDRIAHNCEEQPCDGDVAVRRTTLVDPPPLFCVLKVADPHHLNIGVAELLPQLHLPSASGKAVYQLRSTYHGGDDTPHDWAKTATPFTQAEAPSGRTLEHLYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBA1</accession>
    <name>K1VBA1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000321">
        <property type="protein sequence ID" value="EKD01320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBA1"/>
    <dbReference type="STRING" id="1220162.K1VBA1"/>
    <dbReference type="HOGENOM" id="CLU_2039709_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBA1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="121" mass="13925" checksum="2438AE889D1FCDD2" modified="2012-11-28" version="1">MSYYYNTYDSDSDDDYYYSANAVVHTTGYAEVVRPAPAYCSTCDRTFLNEHNLQQHLRSHIHRGTDTLCPFCNRGFSTATGLIHHLERGSCPRAPGIDREQIFRIMKQRDPNGYVTNLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>K1VBD3</accession>
    <name>K1VBD3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_07646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VBD3"/>
    <dbReference type="HOGENOM" id="CLU_085823_0_0_1"/>
    <dbReference type="InParanoid" id="K1VBD3"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC98100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="283" mass="29860" checksum="808BC91B61E3D632" modified="2012-11-28" version="1">MAATKVATKTSSSTKKVAKSSKTDEPKPSSKRSKKAEPVAEDPVLSKAPESDGPKLKKNGEPKKKPGPKPKAAAPIEGEASEPPAKKARKSKADKADKADKAEAEPAPVEEAKVNGDATGGDFVARAKALDATVAGVAMKLKPKEFSTGSYGWTASKNTKVPGPDGDVEVTGTKPKAAKKEKEPKEAKETKTKKRSKKEKVSWLEGIQADGRSRREASDCARVVESRRFAVTSPFQLTSGEAERVQYNLHILALVSSSPRDLTDTTAAACSLCSVADSFPTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VCN0</accession>
    <name>K1VCN0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000311">
        <property type="protein sequence ID" value="EKD01710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VCN0"/>
    <dbReference type="STRING" id="1220162.K1VCN0"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_8_1_1"/>
    <dbReference type="InParanoid" id="K1VCN0"/>
    <dbReference type="OMA" id="WFAFVEW"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="291" mass="32163" checksum="71A4120CC2C3C84C" modified="2012-11-28" version="1">MSAATAARTGIFGRVWAAYLRVLEEHPLRTKMGTSGFMFLLGDSIAQFGIEGRRPFGSQPAVEDEEDSPEWNRKRTLRMLFYGTCVFGPLNHAWLSLVQRVEFANKWRTRVALDQGVWGPFIVSRSDESYVPHILKLTAVFWTGNGVMEGKSAPEVKAKWEMAFVGSYSKSLCVFGPTQIVNFTLTPPQHRLAVQQLVGLGWNTYISYMNNFNNRRLKLAAAELAAAQAAEAEALAHGKIVRSIDPAHPAKGSHEAVEKAQKEVEKRKAKLDKIAHAQGGGADGVATRMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE07</accession>
    <name>K1VE07_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">A1Q2_06631</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="AMBO01000376">
        <property type="protein sequence ID" value="EKC99090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE07"/>
    <dbReference type="FunCoup" id="K1VE07">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VE07"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386459_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE07"/>
    <dbReference type="OMA" id="ESLDCCM"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000017">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EKC99090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="715" mass="75044" checksum="4570931B6965B205" modified="2012-11-28" version="1">MAQRTRTYSSNAATTPTDSSYRLFLSWALADSSIEAIRKSGGRLNEWGIKEMLDYLRRIGYKPDDLNKLNVVHITGTKGKGSTSAFAERILRDQLGGKIGLYTSPHLCAVRERIRVNGEPLSEEEFAKYFFEVWERLEADPKTLTEHTPQFPIYFRLLTLLAFHAFLSLGVDATVLEVGIGGTYDSTNIVPKPIVTGVSALGLDHTAVLGNTIEEIARNKGGIYKPGVPALSVPQEQGGEVLKECAEKVGAPFEVVPIIPPTPLGLPGAHQRINASLAVGLAKSFLASAGKPVPDADEPLPASFVKPLAETKWPGRCQSVGDGAVTWLLDGAHTVESLTSCGEWAWSSATAGAVGPNDPRPPTPNVLVFNCSGGRAGETLLGALLDAGAKTAGLSREELGATFQKVIFCTNVTYSSGEFKGDLTAHAIDPNDLSALATQTQLAEAWRKVNPDYKGEVHVVPSIEHAVKIVRDTKGTPAALVAGSLHLVGGVMEVAGLQGALSMVRGGTHRDFGRKDVAAGEATTLLSVVKLHVEAAIGRRLLRGGARLPASNAAKTGELAAVCQLGIRAANLRRSIGQDKDVGDQAAGPGAPDGEGDGACAAEDGAREELLSGWVLATVRVAHLVAGRLLVHVGVVVRPAVSFYVALPSSTAGHSHDISAHTGSLHVAGPLCVVLGDDLAQVQSVPHAGQSVLLGPVGRVELELDCALAGQQEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE50</accession>
    <name>K1VE50_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_08406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000415">
        <property type="protein sequence ID" value="EKC97326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE50"/>
    <dbReference type="STRING" id="1220162.K1VE50"/>
    <dbReference type="HOGENOM" id="CLU_522947_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE50"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC97326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="521" mass="56323" checksum="D798ED2750943796" modified="2012-11-28" version="1">MPPRRLTDSLMSSLVNYSSQAAANSAPKPEVVKPEPAGEPTPSLSIAHNPTASSSLPIGPSTSEVVNVESAPQVPGIITPSSPSAFSPKDVDRKVRSAVPGAASGPQSSQGKISPIADGLSAGAYGSVISAEATAGIKPLEILPFQPLETLPSRPLQTIPSRPLNTLPSQPLDTFPTRDLLVSRAPYGSILALSTPRTEQTPSVILKIPSPSSKSNAPMASPQSELSSPPSTSSSATKHTEQTDNDVIDSRTQDLINALSSEPPARSLRPRKDVNYARIHHPYMRPHARSRKQSQSSDNPSTASPAKSRASSVLPSTAVSSTRGFELQFPVSGPIDATLTRLEQLYRSPPLAAPDPRRLSQASCTLIKVQAAHLAGILRRRHDAWLIDARRRFDRQQALNRYSVMARSALYASGSGVRSTSSEYLSSDDQTQHQESFDFEHEPLFNIRDLKADSTGTVKAHSLKAAMKKFMDQSNAMFMKEEKRRWAERQESLMILNAAICEGHLDKIDEVLKEDTVIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VE73</accession>
    <name>K1VE73_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_03361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000292">
        <property type="protein sequence ID" value="EKD02305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VE73"/>
    <dbReference type="STRING" id="1220162.K1VE73"/>
    <dbReference type="HOGENOM" id="CLU_622852_0_0_1"/>
    <dbReference type="InParanoid" id="K1VE73"/>
    <dbReference type="OrthoDB" id="10678206at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD02305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="440" mass="47331" checksum="0210E932046A2BCA" modified="2012-11-28" version="1">MDSSQLKTKVLDVAKSLVTGNRNQYEQAIDEYFADDAVYESPVHVAKGKENIEHVFVLHQAFRADSKLGEWKWNDQNKTATFTVRGRYHLPVGDLPWPVNSLSKVTIPLDIRGVQLQVEPDHSSPSPSQTDRGDVDDTKYQVTKFSIPSLAPRNRLLALVTLALRIVSPIVISIASIVVSFFQRHPLSQGLIKTAFAAIYELTTGVLNFIVTRIPIVGSKIKSIRAKADAAFADAKAAPNVDSAPASPHPVEKRKPRQSGRHALAGLLEDEPHPAALIEDRPLSASPGFRGSKAAKAKGVADPPAVVLDAAIGSSVSSKSKKSARRAIADEAAPAGLIEDEPHPAGLIEDEHELLIEDAPVEGLITDGPDSVSVPVSGGASATDTDSGDATSPSPSPHVNLHASDGHAAKHRKSNKKKRNQKQHANYHYSHNHETVKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>K1VEH2</accession>
    <name>K1VEH2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_03302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000286">
        <property type="protein sequence ID" value="EKD02410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VEH2"/>
    <dbReference type="FunCoup" id="K1VEH2">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VEH2"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_0_0_1"/>
    <dbReference type="InParanoid" id="K1VEH2"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKD02410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="144" mass="16669" checksum="335A038FEE098DA1" modified="2012-11-28" version="1">MINYVMLVSRQGKVRLAKWFQTLPSKTKAKIVKDVTQLVLARRTRMCNFLEYKDTKVIYRRYASLFFITSITPGENELITLEVIHRYVEVLDRYFGNLDLIFNFQKAYAILDELIIAGELQESSKKAVLKIVAQSDAIEEGELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VET1</accession>
    <name>K1VET1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_03126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000280">
        <property type="protein sequence ID" value="EKD02530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VET1"/>
    <dbReference type="STRING" id="1220162.K1VET1"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498930_0_0_1"/>
    <dbReference type="InParanoid" id="K1VET1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="74"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="388"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="561"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD02530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="655" mass="69073" checksum="F785C02A39911DE9" modified="2012-11-28" version="1">MASNPASRRNSISHWPEIDFSRPTAPPPKRVKEGVKIYDSPSPAPFLAQINVFDFLLPKCEGISPMPTYSGVLPAILEGSRTMSRQELRDMSLRLAAGLGALGVKSGDVGIVRAEGIEGSVALYALLAAGLVASPLVPDVDMGHQLADSRPSIVFVPPTLLSTFETTNQQLDPRIPDDRVILLSPPSTSFDLQPQRYRTLYDVLAPPSDPVSLNGAASMSPALRLYTPAGRAVILSHLNVTSQLSSAQLELGPGDVALIAPGSPFIASLIPLALGAAVTHSSSSAILTSLEDSEATLAFLPPPAISALLAKLASRDGEARELGLRCIISTGSPLHSLARRVEHALPSVRVLPAYATAETGPPGADGRERRPARPTSAAREKLLLRGPSHSSSSAILTSLEDSEATLAFLPPPAISALLAKLASRDGEARELGLRCIISTGSPLHSLARRVEHALPSVRVLPAYATAETGLAVMHNDDPDSTVGTLAAGLQARLVQMDGSDAPLGPLGGKGELLLRGPSVSTTGHWHRTGDIASVRHGRWSIHGKIANRFSVAGTQVCPERLEALLLRHPHVRDAAVAGSEEGVRAHLVLDAGGEGPEGVAQHVMRYVQGRTRKSKWVRGVVLASAIPRTSAGLVRRGELGAGEVVRYEPSRWARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VFE3</accession>
    <name>K1VFE3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">A1Q2_07899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AMBO01000402">
        <property type="protein sequence ID" value="EKC97796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VFE3"/>
    <dbReference type="FunCoup" id="K1VFE3">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VFE3"/>
    <dbReference type="eggNOG" id="KOG3045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027694_2_2_1"/>
    <dbReference type="InParanoid" id="K1VFE3"/>
    <dbReference type="OMA" id="WIHMLLE"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EKC97796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="421" mass="45646" checksum="2AC1FB428BEBD755" modified="2012-11-28" version="1">MSLFHSAFDTPGAGSSKPMSFGTSGAGKKKKGKASLNDDKLRATAVNVQKLMEQVERGEITEKASAGSEQLGHIPKKKRRGSSASHDEPPASSSKKQKKKRNSLAALTAEAEEGGEPVPKLAEAPKGKKNKKNKQKEEHKPVQKVQPKAKATEGLTKMQQQMANKLEGARFRWINEQLYTTPSTQAVEMMKKEPKIFEDYHNAHRVLTAAWPSPPLPHIIELLNPLPQRSVIADLGCGDAGLAKELVPKGKVVLSYDLVGDGEWVTSADFLTHVPLPGRKGGLAATVAEDDAPVKSKKNKKGGKRDPDAAEVVDAVVCCLSLMGTNWLGGIYEAARILKQGGTLHIAEVTSRFTNVGAFVTAVESFGLKCESREEPSTHFMLFRFTKVASVPQGPARGEPGWDERIKKGEAILEACVYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VG47</accession>
    <name>K1VG47_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000398">
        <property type="protein sequence ID" value="EKC98036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VG47"/>
    <dbReference type="STRING" id="1220162.K1VG47"/>
    <dbReference type="eggNOG" id="KOG2297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032849_2_1_1"/>
    <dbReference type="InParanoid" id="K1VG47"/>
    <dbReference type="OMA" id="ELIQCIW"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="2">
        <location>
            <begin position="250"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="433" mass="49024" checksum="AF2CFBA152DDA6AF" modified="2012-11-28" version="1">MSHTPTSNTPGNASGAAAKPTLTGVRIRQRKGQAKATAKFEPEAFRDSLLLHLALVPTPPTSDALVTKLVQAGTTLEFLKYADQLFEILFAGGLLQPGGSYLDDKRSPVYLLQPADDENLGGWNPVTGIVEVLQRVIQRYRYLQRPLEDTFLPHILGYLPKWTEEQRTKLAEGVALLVTEGQINPKCLTSLAKDHVVKDKVGLHFLTEFFRTYLQKQSIDHLAATLRRSGLRDILSVFPNQIRDKKHLDDYFKEQKLPQIVDWYAKVALSETKDQTVQAIARMINDEESNEQIVEFLKAQQAERPVPEADLCEWIWLGWMAAFDWSGRPNELEKDVVAYVQKLAPTLEPFCNGAKAEVGILNTVQVFCYTDTRIMKAFPQLVKVLYNEDCVSDQAIIYWHNKGAKPQGKQHFLKVTEALVRFLEEQSDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VH29</accession>
    <name>K1VH29_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_07425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="AMBO01000391">
        <property type="protein sequence ID" value="EKC98411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VH29"/>
    <dbReference type="FunCoup" id="K1VH29">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VH29"/>
    <dbReference type="eggNOG" id="KOG3182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070703_0_2_1"/>
    <dbReference type="InParanoid" id="K1VH29"/>
    <dbReference type="OMA" id="DHREKDG"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKC98411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="226" mass="24963" checksum="A952191189CF47C8" modified="2012-11-28" version="1">MASITSASASSALAPVVATGSGSEANPKSATWVFGYGSIIWRPDFEFAEKRTGWVNDHTRRFWQGSPDHRGQPGALGRVLTLVPELGSECWGVCYRLPKEKEDDIMAALDYRERGGYVRINVPFEYEVSPGVTEKVTAITYIASPDNKYYLGPVPMEDMVRQIYFARGESGKNIDYVLNLARHLETMGLADDHIHELAVQLESRAAKEAIPAQLQSPVQTTTQVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VHW9</accession>
    <name>K1VHW9_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_06948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000382">
        <property type="protein sequence ID" value="EKC98716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VHW9"/>
    <dbReference type="HOGENOM" id="CLU_109498_0_0_1"/>
    <dbReference type="InParanoid" id="K1VHW9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKC98716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="147" mass="16522" checksum="02F27DE59B27D927" modified="2012-11-28" version="1">MKRPQKPSRCETVERSHISAALALDQRTPPGYECSTGTHLELVTAVQRLTAETTLALPVLTAREVFGVDPRALTPPTLFSAGQEVDLLTSLRDEYRALYYTFQHTLRRKRCRTPEGASTAVQQWCRLSAEIEFMTNVIVFSGPRDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VIG8</accession>
    <name>K1VIG8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VIG8"/>
    <dbReference type="FunCoup" id="K1VIG8">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VIG8"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031567_0_0_1"/>
    <dbReference type="InParanoid" id="K1VIG8"/>
    <dbReference type="OMA" id="ESQTNWI"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000146">
        <property type="entry name" value="PCI domain-containing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="38"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="230" mass="26143" checksum="89AA934CC0C151B3" modified="2012-11-28" version="1">MKCYFRVGKPNLCKNVVRAVTSDPKTPPVEQAPIGDQVTWRFYIGMLAFLAGEDARAATELEWAFLHCPASSKRNQELILTFLIPLHLLRGSLPSAKLLARFPRLQETYGPFVDAIRTGSVQAYDEALERAQPRLVSMNTYLAVERAREICLRTLFRRAWAASDRNSRIPISTFRKALELQRVEVDNDEVECMVANMIFRGFIRGYISHERQTIVLAKTNAFPALSSIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJ85</accession>
    <name>K1VJ85_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_06411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJ85"/>
    <dbReference type="FunCoup" id="K1VJ85">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VJ85"/>
    <dbReference type="eggNOG" id="KOG4224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021483_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJ85"/>
    <dbReference type="OMA" id="VWDKPDG"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000236">
        <property type="entry name" value="Vacuolar protein 8, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKC99211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="503" mass="54173" checksum="82284AF96FD0CD02" modified="2012-11-28" version="1">MGGVCSTCCGQRRKNNYEPLLLENEREAVADLLQYLESSPLAALTTLSFSDNVDLQRSAALAFAEITEKEVHEVGRDTLDPVLYLLTSHDSEVQRAASAALGNLAVNGLEPLIRQMLSPNVEVQCNAVGCVTNLATHGEFFCQEARAHALDENKTAIAKSGALVPLTRLAKSKDMRVQRNATGALLNMTHSEKYQVEIVKADGLKPLLRLLHSSYLPLVLSAAACVRNVSIHPANESPIIEAGFLQPLIGLLSFDENEEVQCHAISTLRNLAASSESNKGAIVEAGAVDRIQELVLQVPLAVQSEMTACVAVLALSDNLKPQLLEMGICEVLIPLTNSPSVEVQGNSAAALGNLSSKAAEDYAPFNAVWNKPDGGLHAYLVRFLSSADTTFQHIAVWTIVQLLEAKDPQLTSNIRNSTILISSIRQLADSAPSDSQPKLHSDDEFDEDGMFEDGEGEIYGLAKRILELVDGDGEDKQGAQQGEDGEEDHAALRASVHQALRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJC0</accession>
    <name>K1VJC0_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000332">
        <property type="protein sequence ID" value="EKD00871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJC0"/>
    <dbReference type="HOGENOM" id="CLU_536584_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJC0"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="508" mass="53874" checksum="F2B9725A4ADEF655" modified="2012-11-28" version="1">MRSHDDERCVFRCRLGCLNTWFSNASTWADHNKRIHGSSFAAAVTEAEIDPTSSSAMVKVDGTFVERFDDIWKVEVPAVFGTLASAELRCPAEACGGRELESGTALALHVFDQHLSPHFHTEVEPEMMTSQKTATALALRRCPLPQCTRRPAFKTDKKFVAHLVDHITERTATLSTSAEGVGENTAGAVRDLSQKPDNEQEKAPASAARPTPSTREVTEEVTAPSKVASVSAAPELTAPTAAHQNSAAPMLAPVPVATPSTVIQPPAVTTVTPAIQRAAVVAAPPAPRPVPVAAATPLHPPAPVLASAVLPQTATQPRNPAAKSLSRPSACIATASPSKSAPAEAPLFTPAAVVSVAPPAQPNSQKPEQEAERLKAELARVRAAAEAATARRRAAEEQVRQAKEMASMRAEQRQAAVDEAGDRLAEVRLKNAFAQLKGANFKRVQEPAVSGRPNKLARLSPAPGTSLYSGGKKKPDTFRGLRCSAHTAAMHSRLSTAVDAHIIYRYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VJI0</accession>
    <name>K1VJI0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000331">
        <property type="protein sequence ID" value="EKD00921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VJI0"/>
    <dbReference type="STRING" id="1220162.K1VJI0"/>
    <dbReference type="eggNOG" id="ENOG502S89P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392865_0_0_1"/>
    <dbReference type="InParanoid" id="K1VJI0"/>
    <dbReference type="OMA" id="QLMENIM"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF10">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="702" mass="75619" checksum="4A96C7254D773FB2" modified="2012-11-28" version="1">MATEPSLNELLGLDPVPELVHNPAEFSEFLNFEDFSNPQSHTGSSPNTISVNHTPSPHSFGPSPPQYQAGDFTFDFSDQQQKYQPQFAGPSTVPLQYQDVNVKQEPAEYLQQRHLMAAQYQQQQQQMAQPQQQMPQQQQVQQPAMAANNQQNLPMAQQAALQQLLASFAQYEQQFGGQPVEDPASAINPSLLAANSLTTPSTPGTSSLTPASHAASYAGPSTVQIPPAPESVDEPLNSISESEMPPSRSARAASTGSNMSEIDEKIDKLVPLSAIFSAGRGKGGKKGGGMSSVVRAEGEEVDDDESWRPSPEEYKKLSSKEKRQLRNKLSARAFRTRRKDYIGTLEAHIKDRDQVIDAIREQLSQSAKENQDLRRELEMLKASTQCVLHPESAATVGQSPAMLTALSEGDGSRNRNQGRRAPAVGVNTRKDLAPFDSSRGFWGGSDSLAGGSTICHTVITPEICLPEQPNVNPLLNALNKKAAEEKASPKSEKKPLPPLPERHLSVQDAGDRKIEGSTFAEWSEDTPYNVRSLDSYRMQLWSRLAREAAADKANVPASMRPKFLVDPASPSRREGSASAPSSAATSVSTLASAAVSATATVASRLTSSFWSAFTGPSSKIDGDKLADVVTGRARLAVVPDTRRSSVPNRVASSTDDLAHAMAGLRVATGGSNPRESIRTRNEGPLSSMTGFLKNPSLSTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>K1VK86</accession>
    <name>K1VK86_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_08514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="7"/>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000420">
        <property type="protein sequence ID" value="EKC97177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VK86"/>
    <dbReference type="eggNOG" id="ENOG502S7N0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1094943_0_0_1"/>
    <dbReference type="OMA" id="RNNMLWE"/>
    <dbReference type="OrthoDB" id="3260152at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007980">
        <property type="entry name" value="Ribosomal_uS3m_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05316">
        <property type="entry name" value="VAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKC97177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="237" mass="27638" checksum="BE55C49FC9FEE89D" modified="2012-11-28" version="1">MLMSSNNYSFNKSLNKGSIHTLNAEKLRTKIIDHFFSPIIALSSKPTFIVSRDKVIVNVFYYIPKSEAELEEDKGYKKVRYGRKKIQSLNQNTLNNLGRTLRKLFDRKVELQFVKLNYPYLNRTILAKYIGINRNNYKFNKVVGSIFRNRPVVKNNFENFSNKYTRLDLPSHMLGMKIRASGRLNSERAKPRLTVIERKLGNFNDKNGTYTELGSWTIKSRHGAVTVKVWITHKMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKD9</accession>
    <name>K1VKD9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_04451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000323">
        <property type="protein sequence ID" value="EKD01226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKD9"/>
    <dbReference type="STRING" id="1220162.K1VKD9"/>
    <dbReference type="eggNOG" id="ENOG502SDW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731943_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKD9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="2">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD01226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="378" mass="38808" checksum="DC2C175EE0692610" modified="2012-11-28" version="1">MVTNHEDAYDAPPEYTPSERTEATAATEGTEYERAPREQHGVSSGPPRLRAESPMCIRSTNGSIKTNYAVRLMAPVPDKPDAELRSANGSIDTSLSLTGTRPATITATSWNGSVRLRTERQGPVSIEAESKNGAVHLWLPRGFDGVVTASSGNGNVKLSEALMESAVLVPHDGAGQAWRVKAPGARGGSGGGGGSGGNGGNGGNGGGGGGGGSRKGIRAQAQIEIEFKFRTGSSKSGAPAVPAPPVPPTPPTPPAPPAASAIAALPKPPVPPAPVSAASAASATSTSSTPIPNPFTPTDDKKSLALAYATADAEREREAGLEANEESVPVHAQWEREDEMPEEKAGPDRVKARTANGNVRIYLADEGEEECSGRCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKG6</accession>
    <name>K1VKG6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000366">
        <property type="protein sequence ID" value="EKC99686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKG6"/>
    <dbReference type="FunCoup" id="K1VKG6">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKG6"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018832_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKG6"/>
    <dbReference type="OMA" id="IAFIKHE"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="412"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKC99686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="621" mass="66839" checksum="A39BDC755C0D9D1B" modified="2012-11-28" version="1">MGKTKTKSGEKRKAEPESTSLFGGKKDEGLSGLFSAAATFTAPTAAKKKAKLAAPEPEEAESVGEDESDTTEDEDEDESADSDVGQEPADEADADYAATRDAMDAAIAKRAQKAAAKRAADGSAAVEAKEAKELAKRVMKGAKAKAAEEAAADEAEESDEDEDSEAEGEAEQEDSDSEAELVHESLKTPAERRKRDAKKYVPEDESRADRDRRTIFIGNVPIECVKEKSALKAHIRAFVPTAKIESVRFRSVAFSKPTVALPDDEEAGNAEGKRARREKARAAAWRNAQDADEGRGTRRGEDDVVDKSKSFLDAKGKRKVAFIKKDFHESAAACNAYLVFEHARPDRPANLPPLMNPFDAAAAALAANGTEFMGNTLRVDTMRSPAAAALSSASTSLSKRDAWLPSGTDPKSCVFVGGLDYAAKEEDVRAFFEALVVSERGAPSEGTYVTSVRLIRDRDTQLGKGFGYVHFVDRESVDEVIALPSTKLKFAKRPIRVQQCKTLPGAQKRPVLSAVPAGSKKAPKKLRTAPAVMPKGNPELGEKLKNLSKDERKAAKASDAERLARRLAKKQAKVAAQHRETGAVKLASTKAEKNSRAKNVKAKKGRARSSNAIAKMKGARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKS7</accession>
    <name>K1VKS7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000319">
        <property type="protein sequence ID" value="EKD01361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKS7"/>
    <dbReference type="HOGENOM" id="CLU_1070339_0_0_1"/>
    <dbReference type="InParanoid" id="K1VKS7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="260" mass="28061" checksum="8CC2187CD1F3A496" modified="2012-11-28" version="1">MAVWLGSQCTTGCVQRRSGQQPPGVGVQAHIPQSSDSGTLGVTPTPSPFDSDPTHLGHWDSDLSSSFVDPIYGFCLSFHRTSPYGTHAQSSALGARSLIASLSRLDRDDAAALLNKLKWIRLDTLGTVKAGMAEYGRGSELQGAPISGRDAKWISYRCWVAASTNPPCAGCRYDMISHTSIIVPARLVHNLQRHHHVSAMFSDLSSSNSVVFIDALRSLCTCLVVAMSDGIHDLIISCQRVRIVHLARARTGSAAFRCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VKX8</accession>
    <name>K1VKX8_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenazine biosynthesis PhzC/PhzF protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000189">
        <property type="protein sequence ID" value="EKD04825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VKX8"/>
    <dbReference type="FunCoup" id="K1VKX8">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VKX8"/>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_2_1_1"/>
    <dbReference type="InParanoid" id="K1VKX8"/>
    <dbReference type="OMA" id="RINNHAD"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD04825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="32244" checksum="0F10DBDF2DDD43E8" modified="2012-11-28" version="1">MAPLQFYLANAFASTPHGGNQAAIVLLPSGDARASDEKWMSNVAKDFALPMTAFCEEIDAAAGQYSMRWFTPAGMESPLCGHASLATAGVLFPFFPSLKALSFKTQKRGTIVATLNGLENGAIDVGLSLPIAEAPQPSADTAAMFGPVISRATGLTPDKFVQFARIEHGEGVIAELTPDVDLQNLPVDTSKLLPELKHHGVLTQVVGQGEGGVRINSRVFVPAVGIPEDPVTGSAHALLTQYYLAGPGAPRITAVTGVQNATADAQGTTLDAHQVSVRGGAMKCQLVDGRAQVVGRVYQWAEGKLNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VL55</accession>
    <name>K1VL55_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_00781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000186">
        <property type="protein sequence ID" value="EKD04920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VL55"/>
    <dbReference type="HOGENOM" id="CLU_577708_0_0_1"/>
    <dbReference type="InParanoid" id="K1VL55"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD04920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="477" mass="50611" checksum="F7081041DE5F12B8" modified="2012-11-28" version="1">MRQMQVDKQTRVSIAQSLAYANSLFESSSARHHCALIGIRCATTLVLSPKLVAVEVADWSSTGKVVGVRELLSNLSHESLPHSLLREDGQLDAEAFGLFQGWIRAAIIDQAHRDASTPLNRVALGAHTNRSVAEYEAQIGSRIPFSVEEEDRLSVVRTARSVSTHQTSSKSKEEHGCSTGGEDRHDKDDGGAGGSGGSGSAGTGQCNKRAARTARTGGSQTTTSTSTAAGSASTHSKSRTATTASTDDANALSLDLGGSLAGLDISDQLGPEDLQALNAANESLPLGADAESFAASIDADPELLASLLREEKHGPLSVKRWAANPENGDFVLAVLTAALEDLGCMVKVVSPDEMSQLRAEERRVESPEGSREHFPSSTQRSPALPELDYSDETSSPSPVSTAQLHTVLLPRVTGEEPSTGATPPEPGMASPFAEQRAEADDDQPGTPATRRPRLRETSATRRLRMRVAERRRRTAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>K1VLJ7</accession>
    <name>K1VLJ7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000313">
        <property type="protein sequence ID" value="EKD01596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VLJ7"/>
    <dbReference type="STRING" id="1220162.K1VLJ7"/>
    <dbReference type="HOGENOM" id="CLU_500768_0_0_1"/>
    <dbReference type="InParanoid" id="K1VLJ7"/>
    <dbReference type="OMA" id="TPRGHWA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="544" mass="58482" checksum="F8CFFEAE14038DCA" modified="2012-11-28" version="1">MFLLKRRSSSKHHRASSWGSLLDRPKIPPAPVPEIPTSRLDKEPPCIPELGLLARRNSISGGAEETLTDETQSAESVTPPRASTPAPRPSTPARASSPRPSTPMATPKSAPRPCTPARTPSGEKSSAPSTPHYQKARPSTAEPTPERRMSSPPPRKSSPPSRAAALRKSLLPARKASKMAMPETPKRFKDSISAPTPVPGRTPSMPSIDIGAAASLGSSPPSRRPSIPKSDEEVKPPDRPDRPPTPGCEATTTTRRPPAPSYSSDSLRSNEYRLPSASPSDFQRTMERLSLSAIGSRHSVGYGFVPYLPLSESPAPMTPPRVASPPVIATPPARATSPPPIRSYVPLPLEPQATGVSYNEPITRYATPLSVPELPLPQTAEVLTRSTSTGSSGSGVPSLSSSFNSCSESDEDLPPLHRPSLAALEADADTDIDPELPPFNALLLLHNDKPGRKPVPRETLWRHASVAGAPPVPPRRRSEGWRLELLRIVRGFDDVATAKEERDVVRKVGDPGLGEREALNVVRMFVDEIHARVRLGERCRGFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>K1VMY6</accession>
    <name>K1VMY6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">A1Q2_00136</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000089">
        <property type="protein sequence ID" value="EKD05555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VMY6"/>
    <dbReference type="STRING" id="1220162.K1VMY6"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="K1VMY6"/>
    <dbReference type="OMA" id="STSEQWR"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EKD05555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="485" mass="54085" checksum="E865A627972FE6F7" modified="2012-11-28" version="1">MPLSPKAYTLLCGCFAALGSILFGYLTGQDSSTQNYIGFITSSLLLGAFVGCIPASLIADMFSRRVAITVGAVTFLLGGALQTGATNKEFMMAGRFFAGMSIGQLALLVPLYQSEIAHPSIRGRLTTLQQFFLGIGALTAAWINYGMIHNYLGTALQWRFPLGFQMAPAVPLLFVTLILPESPRWLMLKGREDEALLTLAKLHARGDTSDPFVLGEFHEMQAKIREEAQIDQGWGQIFHNPQNFRRVMLGVILQFSVQMTGVSFLQYYAPRIFAKVGFSTETTLLLGAAGGFPNMASQFAVVMLVDKLGRRRPLIVCNAISGFLYIFILWITYKFTVDDSGTATMGRAFVALTWIWNIFFSWIGSLSWAYPVEIMNSAIRAKAVALTSMACWIANFMICGWKYYILFVVCGFTNAFTMWALFPETKGRTLEEMDDYFASTNWFVPLAKTKDLDSRARERELAEKENENQFPEKEDGKASVEHLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN49</accession>
    <name>K1VN49_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000332">
        <property type="protein sequence ID" value="EKD00867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN49"/>
    <dbReference type="HOGENOM" id="CLU_070150_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN49"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="341" mass="37338" checksum="CFBD741D6741FEA5" modified="2012-11-28" version="1">MTNIPLVQPLDLTRFTHYQLPESNDRSYRSTPQRSSGSGASGGSGSGSGSGGSATPEGTPQTAHTTQTFGFSPSDSPLSPAPPHSAPHSAPPTTEHHQQHQQHQAQHQLLSGQNIQVHSHLTAPGPGGQAGPGGPGGGPGGHQQLIKMNSPREPNTYWDSSMRPPPAIFAFQPQQPYPMYREYYDNYSPYSQTAAPEHHQQHQQHQAQHQLLSGQNIQVHSHLTAPGPGGQAGPGGPGGGPGGHQQLIKMNSPREPNTYWDSSMRPPPRDLAFQPQQPYPMYREYYDNYSPYSQYPMAQQNDQAEERRRRELQKARRHVCLNTHMSVHTGAKRELTQPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>K1VN58</accession>
    <name>K1VN58_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000062">
        <property type="protein sequence ID" value="EKD05620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VN58"/>
    <dbReference type="HOGENOM" id="CLU_980672_0_0_1"/>
    <dbReference type="InParanoid" id="K1VN58"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="284" mass="32017" checksum="5614F9FABCB69AEC" modified="2012-11-28" version="1">MPTLDIQFYPHLFDEIVGYVHAADDISTLSALRAAGRASKAIVDGLLASHMVVSGAHPCTRYYQVWSEQWARGNRDVRAIDVFPYDDESTGQGTCASFLRNCKPHYLRLYGQRSVPFAPSLRALIKVMSYSAPLEYRPFLLPCAHNVMVLDAHVAASLQFFDIEPCGKAHLTLSLSPFFAAGPDLGPRDRAVVFSTLNNVVRWAEDQLELYPGLTIAFLGLERRKRGFAYQSTWQAVHDDRMIAWASEIVFDMHVDYAERMSFLSHSSFRAKVGDEMYRLVVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPH3</accession>
    <name>K1VPH3_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000318">
        <property type="protein sequence ID" value="EKD01382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPH3"/>
    <dbReference type="FunCoup" id="K1VPH3">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VPH3"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_7_2_1"/>
    <dbReference type="InParanoid" id="K1VPH3"/>
    <dbReference type="OMA" id="EAHIGGN"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD01382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="168" mass="18017" checksum="B4F663260F7B319B" modified="2012-11-28" version="1">MFAARRLATVSSHFASVSAPRVSVTASARPQLFAAAASPRNSAKVGSSFSSAASPEAMSDAKTLVDNAIKDNDVLVFSKSYCPYCKRAKAILEDITPDVKVYELDEMDDGSVIQQYLKSLNGQGTVPHVYIKQHPILLLTTQANAQFIGGCSDLQAIPKNQLVKQIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPQ2</accession>
    <name>K1VPQ2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate dehydrogenase protein x component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPQ2"/>
    <dbReference type="STRING" id="1220162.K1VPQ2"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035825_0_0_1"/>
    <dbReference type="InParanoid" id="K1VPQ2"/>
    <dbReference type="OMA" id="AITKFAM"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD01452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="294" mass="30720" checksum="D88C422CE3F79450" modified="2012-11-28" version="1">MPALSPTMTEGGVGAWKKKEGESFEAGDVLVEIETDKASIEVEAQDDGILGKILVEGGSKNVPVGKVIALLAEEGDDLNNLEVPEEGGASKSTAEKPAPKSEEPKEEKSEAPKAAEPEKSAPKESAEHSEIDPSINIFPAAERLLWDHPLSNEQLKAIKPTGKHGKITRGDILAALGKIKSPYGTAEKYNTDPMGPSGRRKSEGPRPASEGQKPAAAPEKPLDGPALRRLIVSGLGKAAAPRPAAASNPGPLTPTDAEYDDIFGDYFPSAPKPATPPPAAAESQPKQDELAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VPS5</accession>
    <name>K1VPS5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_04221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000315">
        <property type="protein sequence ID" value="EKD01472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VPS5"/>
    <dbReference type="eggNOG" id="ENOG502S8B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_2_1_1"/>
    <dbReference type="InParanoid" id="K1VPS5"/>
    <dbReference type="OMA" id="IKADEYW"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD01472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="158" mass="17818" checksum="9E7C14BEF3E9D80E" modified="2012-11-28" version="1">MLTALTRTAASRSLARSLHTTPARTMPLYVCYCPDYPDNLQTRLKAREAHLAAATEDKKTGASESRDEAWVCSGMQLTPVFGRAFLDDKRSTHTEKQPHEDQLSGMDGSVMILRQPTIEAAWDRIKADEYWKQGVWDKEKVVVREIIGAPVDETIKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>K1VQ06</accession>
    <name>K1VQ06_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_02911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000277">
        <property type="protein sequence ID" value="EKD02681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VQ06"/>
    <dbReference type="STRING" id="1220162.K1VQ06"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036940_0_0_1"/>
    <dbReference type="InParanoid" id="K1VQ06"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF3">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="445" mass="48150" checksum="0E29B44A4F324BE3" modified="2012-11-28" version="1">MVSSVTATTHRPNGPNGSVQMASIATKPHSQPNKANRLPFAITIPDSINSSPISPSPASAAQRPTFLHHRTDDNYNFHHLPASSGPRSRTSPVNGGGHHRASLSEHRPSVEVRRLSRPASMSSRSLSVEFEEKSRSSSSSSTGTPLAQTPVFPPAWSHNVTVDHQYPRFASQNAYEHHGQPSRPVGRLVLRAARDRLSCGNKSGALGRGLIVGWVLTTLGFIAAAAFWKGELFSALDHLSKILHDMGYQGLVVFGVLIFITTIPPLPLYSTLIVLSGYTFGACLASSPTATSLLQIIPANPHLLLLIRIAPYPYNLLNVVLASAPSLSLKTYTACTAISLCKLILHTWMGAGIHDLSSAYGATPVDEDRIPEPHEADSQHETLKVAMTWGGIVLCGVLFVYLTHLAKRAIKKAQDETRDRERGLGPEDEQPFLARNSLEEGVRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR46</accession>
    <name>K1VR46_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">A1Q2_02525</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000268">
        <property type="protein sequence ID" value="EKD03076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR46"/>
    <dbReference type="FunCoup" id="K1VR46">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VR46"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="K1VR46"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="131"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="455"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EKD03076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="721" mass="79322" checksum="6314CA56EC5156F2" modified="2012-11-28" version="1">MWTLNAARPVYHASLAAARVSRPRPLQRIAPRRPTLPFAPLSVGVFSTSAFRSVPSKAAAKNNHGSQNNNNNGSQNNNNKSQSSQPSTLNTDVASKAVPEKKQALTDWTILKQLASNVWPKDKPGVKARVVLALSLLVAGKVLNVQVPFFFKNIIDSLNIPLQDNMTVWAIAGASIAGYGLARIFSTVFGEMRNAVFATVAQGTIRKVARETFGHLLNMDMRFHLERQTGGLTRAIDRGTKGISFILSSIVFHVIPTALEISMVCGILSYKFGWDFAAVTALTMLAYTWFTVKTTAWRTQFRKQANAADNKGATVAVDSLINFEAVKEFNNEKYEVKQYDATLKTYEQSSIKIATSLAFLNSGQNVIFSSALTMMMLLGANGVFKGTMTVGDLVLVNQLVFQLSLPLNFLGTVYRELRQSLIDMEVMFNLQNVKPAISDKPGAPPLALRHPGGEIKFDNVTFGYHPDRPILKNLSLTIPAGKKVALVGPSGCGKSTVFRLLFRFYDAQSGRIFIDGQDITDVALESLRKQIGVVPQDTPLFHKDIYYNIHYGNLDASEEQVKAAASKAQLDKTIARLPDGWHTKVGERGLMISGGEKQRVAVARLLLKDTPINFFDEATSALDVYTETELMRNINSTLVDGTKTSVFIAHRLRTISDADLIIVLEDGHVAEQGTHEELLRNIGGVYYRLWNAQLTEGIEEEVVEAAVEAEKQVKGDILGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VR69</accession>
    <name>K1VR69_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_06412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000373">
        <property type="protein sequence ID" value="EKC99212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VR69"/>
    <dbReference type="FunCoup" id="K1VR69">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488518_0_0_1"/>
    <dbReference type="InParanoid" id="K1VR69"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like N-terminal" evidence="5">
        <location>
            <begin position="229"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="7">
        <location>
            <begin position="406"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKC99212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61538" checksum="67851FEC85EF7E17" modified="2012-11-28" version="1">MYDGPVRGENYLGATVNAPVGRWQNNRDVHWYSRDVDTDSKAEAERRREEIRKLKEQEEEALSAALGFAPAKSSGEGSGANSIPVSGDDKERRRQEKMAQKRLDRQLRREERYERRHRTKGRSSRGRERSPSDRREREGRDRDRRDRAPRSRSPHNYRVVDDDAYGKDSKAKSGAGHSGGSHHQNFWPVTSYNSGYGQLTDKDTEVSAAGCGTKLTSQWSCVSNKGFQTETQTWYSVLADGSILMVQVIWSYLGVFLIPATAQMTFKLFNPTTKTTTWKSVNVSNFKHDGRNCKSDSFEIKHSGSASGEEAYHITANLDKNVQIDTVWTRPASAPGCKYGTGEDGGFSYFGKDKSEDKRDALVVHSGQVVIDGKAIDATGNAMFVDAIQGGMRPNLDDYGPAGKGSGHVKVNIGVIYASNLSAPLLVVGQTHTPEPTSVFPVPNQDVSTATHLNTYKDDTGYMAPKGLAFVFGGVREDNKAPAKAELVIDDVTKGFIEKVDVLAEIPYVIRKGYAAISGTKPFIFQYHNPATLQVDLGDKTVPVKGWVYNEASFISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VRC1</accession>
    <name>K1VRC1_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_03727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000302">
        <property type="protein sequence ID" value="EKD02027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VRC1"/>
    <dbReference type="STRING" id="1220162.K1VRC1"/>
    <dbReference type="HOGENOM" id="CLU_1082543_0_0_1"/>
    <dbReference type="InParanoid" id="K1VRC1"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD02027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="257" mass="28171" checksum="980A5F58961D124D" modified="2012-11-28" version="1">MPPGSPSRHDRLHERRSTDIWTEEHAAPTLADVVLPPRRRLRDGTRASSPKRARTRSTRSGTSTDVEAVDEEQQRRLPRLRRRERADPRSASPDRPLPQTEEGPPLSPHSPPHDPVAAQDAFVPFASPRTARSTSSDDLPRRFTAQEKGKGRAMTPEVIEIPDDEPGMDESIQFLDHAPAPPRPVKEVQSAIAEDDALSAFSELPSPTRANIRLPRVLLPADSAGTDAVRACAVLLVSAQFDGRLARTTSEPLAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS37</accession>
    <name>K1VS37_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_02298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000252">
        <property type="protein sequence ID" value="EKD03411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS37"/>
    <dbReference type="STRING" id="1220162.K1VS37"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_1_0_1"/>
    <dbReference type="InParanoid" id="K1VS37"/>
    <dbReference type="OMA" id="NEFIPPW"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="609"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD03411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="791" mass="88370" checksum="BCD053A9E7AC398C" modified="2012-11-28" version="1">MSPPGDVKRNVVATTATDEIAIKGTAGPDVSVFEVYHPSADSITISGRHFIDPLGRVLGLRGANVGSASKVPSEKVPVDRMAENSYVNRPFPLEEAPEHWARLKSWGLTFIRINVTWDAVEHAGPGQYDTEYLAYLRTLLESLRGTGLVAYVSLHQDVWSRASGGSGAPAWTLTECGFDLSDDGAALEASGAAYLHGIRSSVIEGERGLWPTGYQKLACATMNTLFWGGDTFSPRFKIRGQPAQEFLQSHFLNMWKTLVDAVGDLDTVMGFEMLNEPHPGYISIPTIRGWNYNTDLHLGQYPTPLEGMAMGAGHPTEVANYVRSWPHPTKVSHRELGNSDGIAAWSKDGPTGGRCLWESEGVWSWSAEKKRPVALQEDYFTKDRSGRTVNWYNDYYFPLIKKWEGIVNGVAPGKARMIEPLPNEFCPVWPEEDRPRHFVFAPHWYDLHALFNKAFGTMTVNVQGAARGKFILKCLYFGKQVKDNYALQIRNIVTEARKKIGEVPVCFTEVGIPMDMNKHEAFTTGDWKWQNRMMDALISALESSLVHFSLWAYNPHNTDSHGDDWNSENFSWYSDASRHLEIEDAPESDRSLVASSPDTGGRLLGVIVRPYAIATAGQPLSHVYHADNGLFTYRWRDSPSAATASGVPPKNRVTEIYLPNRVYGAAIKDGTLKHFISPGGRYRFDPERQRMWVWFEDDSVSVKQGHEKTRRIDVWVKEPQEDTPVGIIVGLLVILGMSLFVLGSEVCRIKYGKAWVDLPVLAWEGTKKHREQLALKAVQTAAQAAQKVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>K1VS46</accession>
    <name>K1VS46_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uracil transporter FurD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_03336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000290">
        <property type="protein sequence ID" value="EKD02357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VS46"/>
    <dbReference type="FunCoup" id="K1VS46">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VS46"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_2_0_1"/>
    <dbReference type="InParanoid" id="K1VS46"/>
    <dbReference type="OMA" id="WRTGGMI"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD02357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60816" checksum="D4603F340B4AC5AD" modified="2012-11-28" version="1">MRKTNMKQYLSKSYWLLPKEDSCIAPEGVWSNKDMDPTPIEYRTWTGWTFFSYWVCDLFQPGGWATTAAFVGMGLMWWESCLAVLAGSFLSAIVIACNGVVGGTLHVPFAVSSRAVYGYYGSRFVVISRCIMGCFWLSINTFAAGQYVSYAIEAIWPSYARLPNQIPASQGATTKDFLSFFLIWVIQFPFLLVHPSKLQPVFYTKACLVPVVALGTMIWALVKCRDGPGIAYALSTPQNRVSAGVPRFIAFMYSVTSVQGTWATMGVNVADFSRYCRNPKSSWLQLFAFPVINTLVSIVAAITAACLLPVYGDVLYQPYLIVSKWGTSPGGRAAMFLASLAWALANVTTNVSANSISAANDLAALFPRWMNIRRGQLFVAIVGVWGFAPWKVLQSAANFLTFMSSYSVILAPIASLMFFDFFVIKHGRYNVYELYVPHGIYYYTKGWNWRAYVAVICAVAPNMPGMVNAINPNIKIGNIKYVYMVSNIVAHFIALNVYYILNKLFPARQTLIDHPVHDVLEDTPAIPMNYEDSSDMEKNEKLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>K1VSE2</accession>
    <name>K1VSE2_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">A1Q2_02229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 8904</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="AMBO01000247">
        <property type="protein sequence ID" value="EKD03511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VSE2"/>
    <dbReference type="FunCoup" id="K1VSE2">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VSE2"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_1_1"/>
    <dbReference type="InParanoid" id="K1VSE2"/>
    <dbReference type="OMA" id="TIHCKLP"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EKD03511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="127" mass="13581" checksum="6C715E67004D2E34" modified="2012-11-28" version="1">MFKSVLPTATRALRTSNLTATRSFHTTLSRMGVTVDPGDGKTFPKKGDKVTIHCKLPGLNLANGKTLCTIGVGQVIKGWDEGVPQLSLGEKAVLTATPDYAYGARGFPPVIPPNSTLKFEVELLKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTB6</accession>
    <name>K1VTB6_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000355">
        <property type="protein sequence ID" value="EKC99932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTB6"/>
    <dbReference type="HOGENOM" id="CLU_095068_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTB6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKC99932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="200" mass="21927" checksum="E6559E9E1C4FE13F" modified="2012-11-28" version="1">MTDRNKDEKLPSVPSLLDTPEPSPTVSPDTSPPRSGSVAVTTKTHGVNFTGSTSPADYVFNIDLPPSAHPPDVQAYLYCVGSAAPSTKGTEWKWGVEAGARLLRSVRDDGQGVPLPEGMIGAGHEQWIEMIAWLYANHPAMLRLNAFDRPNGRWPTDDGLRRYRDGLMWLSAPEYGGDPEVGEAMYLIDEYNENDFEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTF1</accession>
    <name>K1VTF1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">A1Q2_01854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000240">
        <property type="protein sequence ID" value="EKD03841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTF1"/>
    <dbReference type="FunCoup" id="K1VTF1">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VTF1"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1327213_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTF1"/>
    <dbReference type="OMA" id="ARGWITD"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EKD03841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="23359" checksum="5B2E92756F041EE6" modified="2012-11-28" version="1">MSCLDVSACFASVSSYFSTMKIRHVGLAVVHCPKTRRVLLITSRKHPNLWIMPKGGVEKGETSGEAAAREAHEEGELTSFRQADNTAGIPAQIPEDDISPELCTIESAKPGVEVWHVHAIAIDSEKDLDKDWKERHERKRQWCSHKEALKLIRQWEGKSYACDEGIDDETDEDAWKRGGSKKKRAKGQAFEQALFAFVEKFGYDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTM4</accession>
    <name>K1VTM4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTM4"/>
    <dbReference type="STRING" id="1220162.K1VTM4"/>
    <dbReference type="eggNOG" id="KOG4080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2499471_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTM4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="86" mass="9065" checksum="156DCF07AEB780F5" modified="2012-11-28" version="1">MSAIARPLFSLRPRLTSALAFAPAAVAVGGFPVLGRLAAGVMGGLSSLLELLPPIVLAVPKRKVTHSRKSMRSANKHPKNKTKHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTP9</accession>
    <name>K1VTP9_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_02733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000272">
        <property type="protein sequence ID" value="EKD02952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTP9"/>
    <dbReference type="HOGENOM" id="CLU_1385053_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTP9"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD02952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21002" checksum="6B59601632B713A1" modified="2012-11-28" version="1">MLVERRVIIPYASFPHIIEAILWQADYKTLHAIRSTCSSLKTAAHKVLWDGTVRVRMEERTPVAEQALTLGSGLDVVLRSGVGVLPVLEDNGAGAAGCREELAASAALRSALNNIPSSADVVIKHIAAQPNVAYLPPSSHLTVVLDPLCNCARGLPASHLRATFLSSTHRTGTTESMSLPHGFVESLVLQSHPLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>K1VTS2</accession>
    <name>K1VTS2_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000350">
        <property type="protein sequence ID" value="EKD00088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VTS2"/>
    <dbReference type="STRING" id="1220162.K1VTS2"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396472_0_0_1"/>
    <dbReference type="InParanoid" id="K1VTS2"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="695" mass="75841" checksum="D937C5A07DD387B5" modified="2012-11-28" version="1">MLRSSPVAGSGSFPESESEETDPLSLSLAITDLTPYVFPRDPGSPNRNRNNTLSLLPFPTPTFHFAQVRTPQLCRITQHYHPAGTPSTPSQAQLFSETTFVLHHPLINNQIACPHSQPPSDPSVHPYFTQTTSPLSTAAPRVLLLCLPLLLHNLTPSPLNHSWQKRSTSFSDQGTAASPAAPVASSATSSGQYCGYGPEKPPNPRKRRRKPVITPVSQQSMNVAGPSHAGHPTPTMVAGMEMVSPATSASGPSTVGVGSRLPFDPNEGGQIDWISTQTQKRLMVDPDEMLTFRHYIEHSDDLIAFNEKSSTFNPWVTIHAPLVFQNLPGVSRTTDALRTAVLAVGAVRLRFVDDPTNQKAASKVARQAHLKIMSLLEPILNNPNDHLEEIETTLAALLSVLVACTLAADNIWEEIMKISVKYINNLGGAAKLITNLKPQQNMLSVTRFALEQLAVRDIVACMTLGRRPSIIRQAFEPWFFEIERWSGRDVEWESVERMFGVSRSMVDVIARACSLIGISREAMVAPMPENTPRGLQDAANGLLTELQVWDHGFSYSPYHTRTQYGNHCYRHAMRIALMRDVMGLDRMDERVVSSASAIVELARELNFARGPTMNCEYAATPTTAGSQVYVGGDMGAPAPPPTAPPYASPYAQAPHPQVNGEPPSAVPRMPQPPQAVSSFQSGFHGFAPPSSALWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>K1VU46</accession>
    <name>K1VU46_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytoskeletal protein binding protein Sla1 family, Shd1 (Predicted)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">A1Q2_05410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000345">
        <property type="protein sequence ID" value="EKD00233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VU46"/>
    <dbReference type="HOGENOM" id="CLU_256003_0_0_1"/>
    <dbReference type="InParanoid" id="K1VU46"/>
    <dbReference type="OMA" id="RTHASHA"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF1720" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="801"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="947"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1329"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="504"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="972"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EKD00233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1375" mass="147475" checksum="D713B0FF3F319BA0" modified="2012-11-28" version="1">MLAASLHTPVHQIKPGRPSPGRGEASTSEIPLSIGHGPKRRMTTEAHKPLDLEALNRRLHLYDDISSQKSLKALASPFQLRTSARLQDSKVGSVAKSAPEATRDPTPSSSKLQPEPASRLHSSSKSKAGKRSKEAGKRSKEASSRSSNSLVLSTDSKSAPSYLRLAPESPELGPGDSISVMAFPTAAAPATPVVPPAPSPAPQDIRSEFLHPRLAEGSEGRLRSELASEATKKAQADAQAELLKQRQRKSAKELSEELYSSLHSNASSLPTTAAPVRQSRRPSAVKSQSTRKTDVPSARKSARSPRPTLQSRAPKPPSTLAACDLQSQVIASTSDSESDHRTRTRSRAPSVRSQRTPVLEKAVAGKRYNSITIPLEDVPQIFYKKISQLNYGPMEDAVPLYLSSQRADGGATPPDSISLSDDDSFTAGPPTVISKDIPPTVISKDVQPNVVPKEAPQADFHREQPTEPCPPRVPTKAAPITDDDLVEQLLDAVEKAASKRKMTRKQQAAKIKELQAALSALKHTHAVTLAKEAEREKKDGETKRQQQLKQLELDVKQKEREIKRWQKQHQLDTDRLLFVKERKGIEYGKAQQQLNIVFALHDEVAPLLARQRSSDSDPPIESDTRESHLSEAQQLQEQYLAGDLSAAQPPQQDPHDHVPEPQQVWNVPPPPIPAMQPTPEPHPLPQGAAEYLFHGQVDDEPRIPVPPPLQPRTLDPSYQQSQVAEQGYLGSSEEYHGDSAGNGDVPSRMASQRAPLSSELGSISGAMAYLTEVLARGHANPNSPSKHHPIKLSTQAAVRELGEKLTQEATQAERSRAQSSASRHQPKTNAERLTNRHDVRIRRPSVSQPAAPTATAPLLSRPGTAIDINKDLPPITPNREVHRRHSMTSTDALGHGRRPMSRASTMKVHQRSATQGSIDMDGRYPRMSTGDDERVAYILEPTLAERTHASHAASARAPPTARPDDLSSIAEESLRAASSLPSAPRASPMVPPPSERLAQASPAPPLKPQQTGVSTRSRRPSFVLLNQPNSASVQAQTTGVQRQVTGVQPQLTGMQLQAEGVQAQNASLQPQATGIQPQPTGEAMRPQYTGMQSQRTGLQPQLTGPPPPPIASAPMPSHSPGLQPQRTGLQSHPTGPPLQSQRTGGSTFQLPSAMKAQKTGVSLHPNPAGVRSPVPPAPSHEASMSDRPLLATTPVPAPSQRSGSILLNPGAPPQPVPAQYTGHVHPQPTEERPTPFLQQQPGSVPPMQAQRTGPRRPASMYAGTPAPPGFSMPWMPGAWGPSTPMPLGASKTGPVPLAGDNVDAADGAPPYAERQPVRQLARLSLGSALSTGASGFGTRHTTRTPGDGGASEQPAAHWRTDAGAAALGVDRALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUI4</accession>
    <name>K1VUI4_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">A1Q2_05275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000341">
        <property type="protein sequence ID" value="EKD00438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUI4"/>
    <dbReference type="HOGENOM" id="CLU_1422360_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUI4"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EKD00438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="191" mass="18802" checksum="41B59674B88096DC" modified="2012-11-28" version="1">MRGNRDLRACIVRCCNSIPGTIDRTPQGCHVIAGSAADAAMRTCTKACPDSSSKKRLGARQADSPCPSSVTSGSASSAVSHHGSNTRTHTSHSESASHASHTHPGSHSTHDDGHSRTSVNSSSATGSAPTTSIVGTSDAAGASVASASVSHSASGSAQPSASGEKKSAAPRAARGVSVAIVCVAAMAALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>K1VUN8</accession>
    <name>K1VUN8_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_05158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000340">
        <property type="protein sequence ID" value="EKD00493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VUN8"/>
    <dbReference type="STRING" id="1220162.K1VUN8"/>
    <dbReference type="eggNOG" id="ENOG502SADI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098390_0_0_1"/>
    <dbReference type="InParanoid" id="K1VUN8"/>
    <dbReference type="OMA" id="TVAFWLD"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD00493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="247" mass="28320" checksum="D47907AE2E38EF5B" modified="2012-11-28" version="1">MASAVWSFVWPLLSSYRPNWASYKQKDAKAARFGAFTATYFPPVVHRAPKNNREAQRMYNHIRTVAFYLDAIPVAADLNLPFNLKFGLDDLISLIPIWGDLVSGLLQLYQVFLCWVFGVPTYLLMRMVLNVIIDVLVGIVPFVGDLLDNLFKSNLKNLNLLESWLLGNNKYQILLMPDNTWMPRPKSNGSWFGMGGSSKRKAQEHRSGRVNKTRRMTKAEANWSWEHVEEAGDNAYYKAEARVDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>K1VV28</accession>
    <name>K1VV28_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_05096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000338">
        <property type="protein sequence ID" value="EKD00608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VV28"/>
    <dbReference type="FunCoup" id="K1VV28">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VV28"/>
    <dbReference type="eggNOG" id="KOG3216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1670628_0_0_1"/>
    <dbReference type="InParanoid" id="K1VV28"/>
    <dbReference type="OMA" id="GCERVEW"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="158" mass="17745" checksum="5087185BB3FB4D0C" modified="2012-11-28" version="1">MSAADNVKLMHAARHARPHSRAGTLTPTRSVNQANRKAVYEKEPDAVKATPEMDAMFKNEYAKAFVARTHDGEAVGLCLYFFSYSTWLGVPGIYLEDLYVKPEHRGSGLGKRLFGYLGEVALERGCERVEWSVLNDEWTKERIEGIEGIKKLAALKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVF0</accession>
    <name>K1VVF0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">A1Q2_04960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000334">
        <property type="protein sequence ID" value="EKD00768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVF0"/>
    <dbReference type="STRING" id="1220162.K1VVF0"/>
    <dbReference type="eggNOG" id="KOG4359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_4_1_1"/>
    <dbReference type="InParanoid" id="K1VVF0"/>
    <dbReference type="OMA" id="PYISIGH"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="6">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 5">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EKD00768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="174" mass="19671" checksum="BF7F8C6119483ACF" modified="2012-11-28" version="1">MKFLSCFGEKQKTALDEDALLEGQKPGCVFCGVTREKGFDIIEEDEELIVFRDRWPRAAEHLLIIPRKHVISVVPELTARDIPMIERMEARGRALRPQPGVKTGFHIPPFSSIHHLHMHVLVPPWRPLGKVQYPVREGEDGGKKWTWFVKPQQVVSILENGGRVGLGAQAGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVG3</accession>
    <name>K1VVG3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 14">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">A1Q2_01177</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 14"/>
    <dbReference type="EMBL" id="AMBO01000222">
        <property type="protein sequence ID" value="EKD04526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVG3"/>
    <dbReference type="FunCoup" id="K1VVG3">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVG3"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="InParanoid" id="K1VVG3"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000006">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EKD04526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="519" mass="56388" checksum="67E1ADB5E2E8217B" modified="2012-11-28" version="1">MSTVPEQAPAAAPAEGVEKPKPRRRFVGKTPGSAARTAPRRVANQVPDEILNDPALKEAMAALPGNYNFEIPKTIHHVRREGVKTVALQMPEGLMMYGCAIADIVERFTGAQPLLLADVTYGACCIDDFTAREMGAEMIVHYGHSCLIPVNQTSIKTLYIFVEIAIDSPHLALSVRRNFPSDREAFRRSVLGAGPAEPGAKVDIALEADEEKKLSEGAAAEGETPTRLALVGTIQFVAAVQALRDDLEQAMPPLEEQADGEGADDALAKVRKGEIGVWRGKYDVTIPQVRPLSPGEILGCTAPRLPADVDALIYVGDGRFHLESIMIANPSVPAFRFDPYSKKFTREVYEHKEMRAIRGDAVRNARRNLVERGADSWAILLGTLGRQGSLSVLKTVQGSLPPGTDALPPLLILLSELSPAKLALFSKDEISTFVQTSCPRLSIDWGYAFSRPLLSSYEASVAAGRIQGWEGTEVDGKKGAGDYPMDFYADGSLGPWTPRHRPPRPPREPRPPRMTKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVM1</accession>
    <name>K1VVM1_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000332">
        <property type="protein sequence ID" value="EKD00868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVM1"/>
    <dbReference type="FunCoup" id="K1VVM1">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVM1"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="InParanoid" id="K1VVM1"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD00868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="207" mass="23777" checksum="756C63053D8EDA8A" modified="2012-11-28" version="1">MGISRDSRHKRSASGARRAHYRKKRKFELGRQAAMTKLDTTKRIHTVRTRGGNVKYRAIRLDTGNFSWGSEATTRKTRLLNVRYNSTNNELLRTQTLVKSAVVEVDATPFRQWYEAHYAQPVTKKGQAEAPADEGKKSNHVQRILAERKKDAKIDNHLEQQFRTGRLLAMITSRPGQSGRADGYILEGKELDFYLKKLQTRKQKHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VVV5</accession>
    <name>K1VVV5_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">A1Q2_04675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 8904</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000328">
        <property type="protein sequence ID" value="EKD00988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VVV5"/>
    <dbReference type="FunCoup" id="K1VVV5">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VVV5"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_1_1"/>
    <dbReference type="InParanoid" id="K1VVV5"/>
    <dbReference type="OMA" id="WHITRAR"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="179"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EKD00988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="538" mass="58576" checksum="D56E4271E752C2B2" modified="2012-11-28" version="1">MAATSTAPPSVLDTPSSAPSASSSTHTHIPEPGDIPGDFKSSLVAWWSSNGYRDARLAEERLLRKMPFYTPSLRPESKSWFWNNASSASLPNETEDTPEQGTGLVARVRKVFVPTPDPHAAPPRPDVPAASDVESISSGGSSKAAKRLSRVLHHDKERKGDYINTLEFTTPQTTGSREAVVVLHGYGAAQGFFFKNWASVSRSAAATGRRTFFLDWLGMGLSSRPSSHLLSSKQHSVESRVATAEHFFLDSLENWRRQEGIDKMLLVGHSLGGYLSTAYAKRHPDRVSALVLLSPVGFPHNPDGSTRPLPAGADGRKVDGIVAGSNDQAEAAVHKELGADQANLQRTTSAGPATEATDRDEHIKGEARQWRNDSPSTYRKIATRSILWAWERGLSPFSLMRSLGPWGPLLVGKYTMRRFSAQDPDDIRALHAYIYGVTAMRGSGEYCISHLLAPGAYARMPLVERIAGLSVPVTFAYGDNDWMDVKGGNDAQERLREAGNADVHVKVVSGAGHHLYLDNPEETNQLIDEAIRAVPNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>K1VW54</accession>
    <name>K1VW54_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Diphenol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">A1Q2_02059</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 8904</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Laccase that catalyzes the oxidation of certain aromatic compounds, including L-dopa, to quinones, which then polymerize to melanin. Able to oxidize a wide variety of aromatic diphenol and diamino groups in the ortho, meta, and para positions but not monophenolic groups such as in phenol, tyramine, or tyrosine. Plays an important role in virulence. Plays a role in dissemination to extrapulmonary sites but is not involved in pulmonary growth or in elicitation of cellular immune responses in the lung.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000243">
        <property type="protein sequence ID" value="EKD03642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VW54"/>
    <dbReference type="STRING" id="1220162.K1VW54"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_1_1"/>
    <dbReference type="InParanoid" id="K1VW54"/>
    <dbReference type="OMA" id="DERCIVL"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13904">
        <property type="entry name" value="CuRO_3_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003852507" evidence="11">
        <location>
            <begin position="23"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="107"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="226"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="478"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EKD03642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="600" mass="65743" checksum="DE4ABFC856A8CA90" modified="2012-11-28" version="1">MVRLSAFFFPATVALLAGAVNAHDHGHGNGHHHQTSTVEASPTTNPNPPGPFVVPPPPPPDKIFSYPQPALPEQTAARDPSTWKLNRSKHRGHKTRRYNFNLSYTAGAPSGFHRRLTTANAQFPGPLIEASVGDTIEVKVTNDLDEPQALHWHGIRMEGTPFNDGPPGINQCPIPPGGSYTYRFKASHYGTYWWHSHYGATMADGLYGAIVVHSPKDPIRSDAEEVLFVSDWYNDQSNTIVAGLRNTSVGYRGMPIPGIPDAVLINGLGQTNCSHVQPGVTCTQNEAHVVEAKPGSKLRLRVINPDMEAMIRFSVDGHVLKVVEADDTPIEPLYMHELDIASGQRYSVILDLDQPDAAYWMRARIAAGCVLLGRELETKAVLRYRGRDGEPTSQPWPDRAESNAPCVDIDNKYTVVPLHREKLPKPVTQGRMDSAAGEFVDVATGAKFIGFGFNNVTYLNYIQDPVYQQVQEGRPLNTTHFAHLSFSGKGSADLLLNQLDPGIAHPFHLHGRPFSIIARGSGKMTLDGLKDVKLNTVNPLRRDTLHLPVSSWALLRIPLDDPGVWAIHCHLGWHLANGKLAVIVVQPEKLPSLLGSGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWK0</accession>
    <name>K1VWK0_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">A1Q2_00782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000186">
        <property type="protein sequence ID" value="EKD04921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWK0"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254501_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWK0"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="1203"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="805"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1139"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EKD04921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1312" mass="141577" checksum="F9D6BD5439B6F84A" modified="2012-11-28" version="1">MVRTSVPIPANEAPRGQKKDGVVRSSLELVFSYSRSQQRFNGGLPSAPSFVDYQWSADDSDADTGTPGEYDTESAWSGDEHDDSATSEVFFPTDPVRQSQERSMGPAGGALALSTVTEREEEISPKSTPLATPLLPAKRGGIMSLFSTTPPVLSSSVGSNGSQTPRPPVRLLPDVEATSPQTYTGNRYHAQRGSLGLHPFPGPANANKDKDRTPPADNAPLPAERPTESTPLLKAQPSPRRPSRSTPKRWVNGHLSPTVSSRRSSIAGRRGSAVRRRSKQLEHVGESSDGQTLFNACAVLVGIGLLSMPLAFSFAGWIGGTLMLIAFSYLTCHTAKLLARMMFSDPLLTGYTDIGRKAFGPWAGAVVNGLFCLELFGLSVALVVLFGDSMEIVIPRLSSDTYKLIGFFLILPTVFMPLRMLSIPSVMSTLATVVLVGIVVFDGFWKTKAPGSILDPAPTRMGPEMYQLNWLGSIGLVLAGFGGHAVIPSVARDMKKPESCDRIFNIAFFIAAAISFISGAAGYLMIGDVVSDEITREMLDPYYGYPRALNMVAVWMIVVTPLTKFGLCSRPLNVAVEGFLNLAPAPAVVAQREAEHEAEREGRTSTEYARSERYSGEHLRSPLLRPRRHSITGAMESAISVFSTAGVSDYLGEDDSTIGERPKSPLPVAEPDGAAEGRKGIGRIACRIAITVTCVATAVLLPGFGQVLAFLGSFSAFLICIILPLGFWLRLGPRMLKSPETAGDRAWRYFHYVVLFVSTILMGMGTVWSFIPTERPPVMPVSSVSSVSSARVSATTLAHSARLSSTRCSLSPSRNLSTSPSRSRTPIAVPTNPGSENPPNFSPPVEYEPIDRGLPYRRALLLFSIPVPPASWPSHAELMCPLFGSVQFALKSHKIGLNVVYDGVGTATDLKGVTSLPAELVFPDGRVYKWTQFSEATLDEASFLDATRYTAQQPGPGIAGMGVRATQRIMVCTHGARDCRCSERGTPLVHSLRRAISYSNSNATADSKSDTADTADTADTAADPAADLEIVEIAHVGGHKWAANALLYPSLDMFSNLSADDADKFLRFIQSGGEQEKGMWEHWRGRIGYNDLVQMQLGLRVDRIVAESESASESREKANERKEEKKKEEEEEDGDSLDSTESAPTSSGSTATTRTKGNSARSAADPLSDPLSFDTLDPLSGLSDFSGLDTASTRLKYASTPTVPLTFTTFDNKPLSVSAPLGASLLEVARLNNLPGMEGTCGGNCECATCHLHFRPTWEEAPVQEPSEEEEDMLFTALEYRDGESRLGCQVRVTPELAEWNKDGGVLKLPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWU3</accession>
    <name>K1VWU3_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GCF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_01761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000239">
        <property type="protein sequence ID" value="EKD03937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWU3"/>
    <dbReference type="FunCoup" id="K1VWU3">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VWU3"/>
    <dbReference type="eggNOG" id="KOG2184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395969_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWU3"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="2">
        <location>
            <begin position="245"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD03937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="696" mass="77027" checksum="32C0CA647B6116A0" modified="2012-11-28" version="1">MARRKQNILSDGSDSGGDCDNGSESDFDSQEDEDSRAERRLFERRQRKRPRTGRSGKDSAWEGIFGADDGGLDRRSGSGLGNRQRGGGNSRNDWTNFNAGAARLSSGIGSPMINEANDPSVGGLAVPMDYGRFTQMKVFKSPRYVEHKSQNSLERGRGVLPHGVKLHGVLVLLDLFLSLGEDLLLFNLWQTLQTAVSTSGTLFHSLVSVLLIPVLALQRQGGLLVNKKGFGRWSSFSTKSGASSLEPLAPSFNRLLTDLKDEYTRLSLDEVVVGAIDLVLKPSFDAWEPFDVSSDALLSTLMPWRTAFNLAVEGISLPIHEDRQMTAWESLLWHRWLPKVRSTINNDWSASDAWPAVHLVESWYPLLPDFIRDNVLSQLVLPKVMSAIEAWTGRGRGGDSLASVVFPWLPLLGDRHGEVLEESRRRIRSLLRRWKPADGVPQELARWRSDIFSAREWDTIIGEHVLGKLGAVLRDLVINPRDQDMSAIVNEVLPWHSLIRPSNFTRLFELEFFPKWLNVLYLWLVHPGYNGEEVAQWFELWKSLFPAEVLHHKAIAHGFETGVQLMGAALALGPSRSQDLQRPSYSPLSRSSKSSVGGSKAPSTPAPHVAVRHDDITFRNIAEDFIASKDLLMVPLGKSHSTTGKPLFRVGKTIDGKGGVTVYVGEDAVFAQGDSGSFHAVTLDDVVQRAGGAGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>K1VWX6</accession>
    <name>K1VWX6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">A1Q2_04364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000320">
        <property type="protein sequence ID" value="EKD01338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VWX6"/>
    <dbReference type="STRING" id="1220162.K1VWX6"/>
    <dbReference type="eggNOG" id="ENOG502QV4C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012597_0_0_1"/>
    <dbReference type="InParanoid" id="K1VWX6"/>
    <dbReference type="OMA" id="TYHIMWI"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="206"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EKD01338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64575" checksum="D674A5DE410255D9" modified="2012-11-28" version="1">MEPVPPGLYSGTTRKQNVACDACRNKKIRCKRQTTSQRCVSKDLECTSNYIEQLQNKPRRPRRFKSNEEHPKERRPSDHELRSPGPAIRRASAPKAPQSSQGSSSTGRIGMEDALAMIAWVTPPRNSATAKDPSAGQVDLLRYMFCPAPVTHHEWRYSDVSSLEQARAGTCDLWDEEGGALWDDAPSAAHLSLWGGGEAEMAIELIDTFFAVVYSRLPILDAQSFMNRFTSPNTDPNGPLNPALLASVLAFGAKFADHPTFTADRDECAARDADDADGSRSRRGYSRSRCRMAQLLAVRAREVAEVHKAYRIPTLANVQALILLENLFGHRVRKLTVGIQLRQLTAEYRATYLSAAARLMDELEDLPILHVDSQQDEKIRTQLTIHLLAGFETAFYRLRPETFQGVGDVAPLLSVVAGGEEDVGALLFPLLTCQIWLAAARMAIAVYRRLSSALAQPQVHANGVPLSVLRDMVHDHSSWRDLYLSKLGLPVPWPEDWDFNMTVRAASTDILYHALWLVAERAVRDFGIQEREDNSVTGMVGFEVTQMRERLKQEALHSAMRISMVAVLSTEQGHLRLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX63</accession>
    <name>K1VX63_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">A1Q2_04275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 8904</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000316">
        <property type="protein sequence ID" value="EKD01433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1220162.K1VX63"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="K1VX63"/>
    <dbReference type="OMA" id="RMNLINP"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1433"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1463"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1490"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1609"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="201"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="909"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1012"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EKD01433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="1935" mass="213891" checksum="DDBD75CCFCF05876" modified="2012-11-28" version="1">MDQQRPGAETPQNDAYASGSQTGSQAGSQTNIPAAGSSSMLHLRSSTQVTLVETATESPASYDTKPPKDSAAPTLDSQKEEQYHIPENLSRHTSPAITEVRRTSTDTEDGYTEWSFAEQLKARQAALIERGLPPVRNVSLSWQNLSVRGVGGVDDVQFAPDLGAIVAPWTVIKQKKKVEAYAQSVAEKAAAQPGFEPMAWQKGMPTPKKGEPGLRKGQRYLIKDFNGLLKPGEMMLVVGRPGSGCTTFLKALSGLTSSYAGVDGTVRYGSLKAGSKEMIALRGEVAFNDEEDVHDPNLLVGRTMDFATRMETPSDRVRALGKNGKPISEKQYQEETKTDLLRVFGIEHTAGTKVGNQYIRGVSGGERKRVSLAEFLTTDSQVMCWDQATRGLDASTALGFARTCRTLCDVDKRVNVVTLYQAGNGIYDLFDKVTVIAENRLIYYGPRDMARNYFEQLGFEHMEGANTADYLTAVTALNERKIIPGYENKVPNTAAEFAKIYQESDLCAAMRKEVDDWVADTAAREAESDELRRVNQTSKTKYAIKALPQKESWGKQVWGCIVREGQQRWGDQWSFWARQATTLIQGLINGSVYYNVPDNTSGLFLRGGVIFMLVLFPAILAFSDLSEAFMGRGVLGKQKSYAMYRSSLMFVAQVVLDIPIFVVQLAIYTLVTYWMAGLRSNAGNFFLMFFFTWLNSLVFTSLFRAIGYAFDIYNDASKIAGSVFTFFVLYGGFVIYTPSMHPWFSWIRWLNPVYYAIENLMATELTDLTLDCAPPQLAPYGPAYAGQPAGCAIAGGSPGTTKVSGTKYLDLALKFYKSHRWRNFGIMIALWIGAILLGMLFVERLPAAGSKPAVTLYKRGGGSAFRAAAKDAEAAEGVDGEKLNNNGNQKISGAATPRSNIRIGPPRSGTATPRSGTATPRSGMQIGPVTNEKPGLSRTSSRLAEEAQGTTFTWKHLNYFVKAEGKDKQLLRDVSAMDQQRPGAETPQNDAYASGSQTGSQAGSQTNIPAAGSSSMLHLRSSTQVTLVETATESPASYDTKPPKDSAAPTLDSQKEEQYHIPENLSRHTSPAITEVRRTLMDVLAARKSEGTIEGEVKLNGHSLPVSFQRTTGYCEQVDIHLPTSTVREALEFSALLRQPRHISDEDKLAYVDVIIDLLELQDIEDAIVGVPGAGLGVEQRKRLTIGVELVSRPTLLFLDEPTSGLDGQSSYQILQFLRKLAAQGQSILCTIHQPSAALFAEFDQLLLLKAGGRTVYFGPVAKVKSYFTGNGAPWPRDVNPAEQMIDVVSGDISRSKDWAEVWKASPECTQMMIDLDNVNEEAKSQYHETAEDTHKYAASTSTQLRLVIHRATVQLYRDVEYVRFTYWKMGTAYADLQNKVFALFQFVFVAPGVIVQTQPKFIANRDVFESREKKSMFYRWQVFCAGEILAEVPYLILCAFFYFVTFYWTAGFSSEAGIAGPVFLQMVFYEFLYTGMGQFIAAYAPNPVFAAMVLPLFISVLATFAGIMIPYQQLTAFWRYWLYWLDPFTYFMQGLITFPIWDAKVECRPHEYGYFDPPAGQTCGQYLQTFMTYASGYLNNPEAVANCEYCGLKKGSEYLYNLNIKRHIIGWQGILITLLFIISSYSFVFLLLKLRSKGTKTASSKPPLLYTRGLDGAEASAGCLKRTECHAHNRQQQSLASPRQLMATIEHDTTSSSTGERHLLLTRSGEQLALRSPLAPDRDLCFLSSSDSDSTHAFSQCEVLDVSPALLSPELSSTLEAVPSLKAMRLTADDSEELPRVSAFPSTPTLVYLSIPESLVDLKPKAGDMGPFPVCSADTRRLVFNFLPASDERPTYRPKGRRPNVDHVVCVLHDGAGDEAHFWINWAVRYEIETTVVLCGGDFEAKRAALGEQVDLHHIHVQVLSDSDYKAQVGNETFAIETQRFLAPEKEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>K1VX78</accession>
    <name>K1VX78_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000144">
        <property type="protein sequence ID" value="EKD05111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VX78"/>
    <dbReference type="HOGENOM" id="CLU_960386_0_0_1"/>
    <dbReference type="InParanoid" id="K1VX78"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EKD05111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32868" checksum="8C7CD2929A394769" modified="2012-11-28" version="1">MTADTECKIPYSVFPHIIEAILYRSDYKTKLNFRATCRKLRNITNTNLLLDTVMMYRTECPCGSLIVHPYKKHSYPFFKIWGELPWLISRMEGKKVTISDVDAGPRTNALLSTADSLSFTNHTRICNFVLGSQQNFLGLHIDMNCNCGEGGLCPAFSHRAESVSIHLHPDNTYLILAGQEGYNPTDIEVEKDDKTGCHMLQNVLNPYIYEFCLVLGAPFSVDTAKHLPAFLFPKAHQYILHWSFRLSIIIHGMPKSGEVEKKAREAFALHLRIPKAKVNITFDQEAHPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYK6</accession>
    <name>K1VYK6_TRIAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">A1Q2_00024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000023">
        <property type="protein sequence ID" value="EKD05676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYK6"/>
    <dbReference type="HOGENOM" id="CLU_1533666_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYK6"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EKD05676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006757"/>
        </source>
    </evidence>
    <sequence length="178" mass="19706" checksum="C2E2E0D07F5F1C81" modified="2012-11-28" version="1">MTEDNDQVTFGDYVEDDYESTESTDEDSEDSSESEDIEEDDESPRLDLSRLHPSFHDFASSAESAYAALLSHLPRCSRWSRWFGRCPSVEVTGHGLGGALAVLISDHAPHRTAVTTFGMPAIYEGEGRHEHWANGLDPVTRFLPGGSRRLMKDAKEAFHMAKGRLGDHSLVHGVSLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-11-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>K1VYX7</accession>
    <name>K1VYX7_TRIAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">A1Q2_00982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichosporon asahii var. asahii (strain CBS 8904)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="1220162"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Trichosporonales</taxon>
            <taxon>Trichosporonaceae</taxon>
            <taxon>Trichosporon</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1586" last="1587">
            <title>Genome sequence of the Trichosporon asahii environmental strain CBS 8904.</title>
            <authorList>
                <person name="Yang R.Y."/>
                <person name="Li H.T."/>
                <person name="Zhu H."/>
                <person name="Zhou G.P."/>
                <person name="Wang M."/>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="23193141"/>
            <dbReference type="DOI" id="10.1128/EC.00264-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 8904</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AMBO01000191">
        <property type="protein sequence ID" value="EKD04752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="K1VYX7"/>
    <dbReference type="HOGENOM" id="CLU_047748_0_0_1"/>
    <dbReference type="InParanoid" id="K1VYX7"/>
    <dbReference type="Proteomes" id="UP000006757">
        <property type="component" value="Unassem
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